Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	G	C	tCw	wGa	tC	Ga	tC_mutation	tC_mutation_to_G	tC_mutation_to_T	APOBEC_mutation	APOBEC_mutation_to_G	APOBEC_mutation_to_T	[tCw_to_G+tCw_to_T]_per_mut	tCw_to_G+tCw_to_T	BH_Fisher_p-value_tCw	APOBEC_enrich	tCw_to_G_enrich	tCw_to_T_enrich	p-value_GvT_skew	BH_p-value_GvT_skew	APOBEC_MutLoad_MinEstimate	"CONTEXT(+/-20)"	g_counts	c_counts	tcw_counts	wga_counts	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	newbase	end	tum_allele1	tum_allele2	start	effect_idx	newbase_idx	pat_idx	is_coding	is_flank	is_indel	is_ins	is_del	is_missense	is_nonsense	is_splice	is_silent	gene_idx	context_and_effect	context65	categ_idx	trackpos	categ	gene	chr	pos	type	classification	ref_allele	patient	DistBetween_Mutations	Distance_to_LT_end	Distance_to_RT_end	Strain_Mutation_ID	Dataset_Mutation_ID	Complex_ID	Complex_Size	StrainCluster_ID	Dataset_Cluster_ID	Distance_Between_Clusters	Cluster_Size_Mutations	Cluster_Size_Complexes	Cluster_Length	Cluster_Coordination	Content_of_non_coordinated_cluster	Cluster_Pvalue
CDK11A	728642	broad.mit.edu	37	chr1	1650844	1650844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	tgtgatgaactttttctttcCgagacatttgctggggtggt	12	6	1	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:1650844C>T	ENST00000356200.3	-	3	410	c.176G>A	c.(175-177)cGg>cAg	p.R59Q	CDK11A_ENST00000357760.2_Missense_Mutation_p.R93Q|CDK11A_ENST00000378633.1_Missense_Mutation_p.R93Q|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000358779.5_Missense_Mutation_p.R93Q|CDK11A_ENST00000378638.2_Missense_Mutation_p.R59Q|CDK11A_ENST00000378635.3_Missense_Mutation_p.R93Q|CDK11A_ENST00000404249.3_Missense_Mutation_p.R93Q					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						TTTTTCTTTCCGAGACATTTG	0.398													94	172					0	0	1	0	0	T	1650844	C	T	1650844	3	4	1	1	0	0	0	0	1	0	0	0	3148	652	23	1	2132	1	CDK11A	1	1650844	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08		1650844	247599777	1	1										
AJAP1	55966	broad.mit.edu	37	chr1	4772258	4772258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ggccccgggaccaggcggccGccctcgtgcccaaggcagga	16	17	0	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:4772258G>A	ENST00000378191.4	+	2	709	c.328G>A	c.(328-330)Gcc>Acc	p.A110T	AJAP1_ENST00000378190.3_Missense_Mutation_p.A110T	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	110					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCAGGCGGCCGCCCTCGTGCC	0.736													12	3					0	0	1	0	0	A	4772258	G	A	4772258	3	1	1	1	0	0	0	0	1	0	0	0	435	1087	38	1	334	1	AJAP1	1	4772258	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	3121414	4772258	244478363	2	2										
HSPG2	3339	broad.mit.edu	37	chr1	22161313	22161313	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	aatgcctggccgcaggtgccCtccaactttgctccatgtca	9	15	1	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:22161313C>T	ENST00000374695.3	-	77	10658	c.10579G>A	c.(10579-10581)Ggg>Agg	p.G3527R		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3527	Ig-like C2-type 21.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGCAGGTGCCCTCCAACTTTG	0.637													35	41					0	0	1	0	0	T	22161313	C	T	22161313	3	4	1	1	0	0	0	0	1	0	0	0	7473	681	24	3	2680	3	HSPG2	1	22161313	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	17389055	22161313	227089308	3	3										
ZMYM6	9204	broad.mit.edu	37	chr1	35476601	35476601	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gccctgagacaggggcaccgCcgaagagtttgttccttttg	13	11	0	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:35476601C>T	ENST00000357182.4	-	9	1326	c.1099G>A	c.(1099-1101)Gcg>Acg	p.A367T	ZMYM6_ENST00000373340.2_Missense_Mutation_p.A367T|ZMYM6_ENST00000487874.1_Missense_Mutation_p.A367T|ZMYM6_ENST00000493328.1_5'UTR	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	367					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AGGGGCACCGCCGAAGAGTTT	0.458													20	43					0	0	1	0	0	T	35476601	C	T	35476601	3	4	1	1	0	0	0	0	1	0	0	0	17761	739	26	3	2910	3	ZMYM6	1	35476601	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	13315288	35476601	213774020	4	4										
HIVEP3	59269	broad.mit.edu	37	chr1	41984100	41984100	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ggcttccagctcctccagcaCccctgtctcttggcactttt	7	17	1	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:41984100C>G	ENST00000372584.1	-	6	6457	c.5443G>C	c.(5443-5445)Gtg>Ctg	p.V1815L	HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000429157.2_Missense_Mutation_p.V1815L|HIVEP3_ENST00000372583.1_Missense_Mutation_p.V1815L|HIVEP3_ENST00000247584.5_Missense_Mutation_p.V1815L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1815					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCCTCCAGCACCCCTGTCTCT	0.522													42	74					0	0	1	0	0	G	41984100	C	G	41984100	3	3	1	1	0	0	0	0	1	0	0	0	7228	507	18	5	1789	5	HIVEP3	1	41984100	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	6507499	41984100	207266521	5	5										
CCDC30	728621	broad.mit.edu	37	chr1	43021941	43021941	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	caacagaatcgagatatgaaAgatgaagaaaaagaacagca	9	5	0	7			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:43021941A>C	ENST00000428554.2	+	12	1683	c.540A>C	c.(538-540)aaA>aaC	p.K180N	CCDC30_ENST00000342022.4_Missense_Mutation_p.K180N|CCDC30_ENST00000340612.4_Missense_Mutation_p.K180N|CCDC30_ENST00000390640.4_Intron|CCDC30_ENST00000507855.1_Intron			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	180										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						GAGATATGAAAGATGAAGAAA	0.443													24	16					0	0	1	0	0	C	43021941	A	C	43021941	3	2	1	1	0	0	0	0	1	0	0	0	2824	69	3	4	554	4	CCDC30	1	43021941	Missense_Mutation	SNP	A	TCGA-N5-A4R8-01A-11D-A28R-08	1037841	43021941	206228680	6	6										
SGIP1	84251	broad.mit.edu	37	chr1	67148015	67148015	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	aggactgtggtttcgtccccCggacctggctcgggccctgg	15	14	0	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:67148015C>T	ENST00000371037.4	+	15	1355	c.1278C>T	c.(1276-1278)ccC>ccT	p.P426P	SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000237247.6_Silent_p.P430P	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	426	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TTTCGTCCCCCGGACCTGGCT	0.562													158	154					0	0	1	0	0	T	67148015	C	T	67148015	2	4	1	1	0	0	0	0	0	0	0	1	14259	639	23	1		1	SGIP1	1	67148015	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	24126074	67148015	182102606	7	7										
CELSR2	1952	broad.mit.edu	37	chr1	109793392	109793394	+	In_Frame_Del	DEL	TTC	TTC	-													0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ttgatagccgctccaaccagTtcttctccctggacccagtc							TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:109793392_109793394delTTC	ENST00000271332.3	+	1	752_754	c.691_693delTTC	c.(691-693)del	p.F232del		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	232	Cadherin 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCCAACCAGTTCTTCTCCCTGG	0.616													18	38	---	---	---	---						-	109793394	TTC	-	109793392	7	5	1	1	0	1	0	1	0	0	0	0	3244	1725	60	0	693	0	CELSR2	1	109793392	In_Frame_Del	DEL	TTC	TCGA-N5-A4R8-01A-11D-A28R-08	42645377	109793392	139457229	8	8										
ZBTB7B	51043	broad.mit.edu	37	chr1	154987608	154987608	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	cggacgaggatgactgtgagCgagcccgccagtatctggag	16	10	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr1:154987608C>T	ENST00000368426.3	+	3	609	c.472C>T	c.(472-474)Cga>Tga	p.R158*	ZBTB7B_ENST00000292176.2_Nonsense_Mutation_p.R158*|ZBTB7B_ENST00000417934.2_Nonsense_Mutation_p.R192*|ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000535420.1_Nonsense_Mutation_p.R158*	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	158					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGACTGTGAGCGAGCCCGCCA	0.637													33	109					0	0	1	0	0	T	154987608	C	T	154987608	4	4	1	1	0	0	0	0	0	1	0	0	17612	760	27	1	474	1	ZBTB7B	1	154987608	Nonsense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	45194216	154987608	94263013	9	9										
TTN	7273	broad.mit.edu	37	chr2	179597447	179597447	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gttacaaaactgggtggttcTgaagaaggggtataagaaag	14	3	1	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr2:179597447T>G	ENST00000589042.1	-	56	16567		c.e56-2		TTN_ENST00000342992.6_Splice_Site|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Splice_Site|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGGTGGTTCTGAAGAAGGGG	0.398													10	10					0	0	1	0	0	G	179597447	T	G	179597447	5	3	1	1	0	0	0	0	0	0	1	0	16796	1594	55	4	88416	4	TTN	2	179597447	Splice_Site	SNP	T	TCGA-N5-A4R8-01A-11D-A28R-08		179597447	63601926	10	10										
IRS1	3667	broad.mit.edu	37	chr2	227661386	227661386	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ttccatagctggtcccggaaGggacggcgttgctgctgctg	15	11	0	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr2:227661386G>T	ENST00000305123.4	-	1	3089	c.2069C>A	c.(2068-2070)cCt>cAt	p.P690H		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	690					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GGTCCCGGAAGGGACGGCGTt	0.627											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	59					1.60099e-16	1.72574e-16	1	1	0	T	227661386	G	T	227661386	3	4	1	1	0	0	0	0	1	0	0	0	7883	1000	35	5	1663	5	IRS1	2	227661386	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	48063939	227661386	15537987	11	11										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			37	4					0	0	1	0	0	A	178936091	G	A	178936091	3	1	1	1	0	0	0	0	1	0	0	0	11960	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		178936091	19086339	12	12										
ECE2	9718	broad.mit.edu	37	chr3	183995214	183995214	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	cgctggaacaccttcaacagCctctgggaccaaaaccaggc	9	15	2	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr3:183995214C>T	ENST00000402825.3	+	4	792	c.792C>T	c.(790-792)agC>agT	p.S264S	ECE2_ENST00000357474.5_Silent_p.S192S|ECE2_ENST00000404464.3_Silent_p.S146S|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Silent_p.S117S	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	264	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCTTCAACAGCCTCTGGGACC	0.612													17	45					0	0	1	0	0	T	183995214	C	T	183995214	2	4	1	1	0	0	0	0	0	0	0	1	4916	738	26	3		3	ECE2	3	183995214	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	5059123	183995214	14027216	13	13										
ENPEP	2028	broad.mit.edu	37	chr4	111436563	111436563	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ttttgagaatgcttgaagacTggataaaaccagagaatttt	9	4	0	4			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr4:111436563T>C	ENST00000265162.5	+	8	1816	c.1474T>C	c.(1474-1476)Tgg>Cgg	p.W492R	RP11-380D23.1_ENST00000503998.1_RNA	NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	492					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GCTTGAAGACTGGATAAAACC	0.308													23	19					0	0	1	0	0	C	111436563	T	C	111436563	3	2	1	1	0	0	0	0	1	0	0	0	5156	1580	55	4	1504	4	ENPEP	4	111436563	Missense_Mutation	SNP	T	TCGA-N5-A4R8-01A-11D-A28R-08		111436563	79717713	14	14										
HHIP	64399	broad.mit.edu	37	chr4	145580958	145580958	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ttttcaaggagccttatttgGacattcacaaacttgttcaa	6	8	3	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr4:145580958G>T	ENST00000296575.3	+	4	1454	c.799G>T	c.(799-801)Gac>Tac	p.D267Y	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.D267Y|HHIP_ENST00000511314.1_3'UTR	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	267						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GCCTTATTTGGACATTCACAA	0.363													60	55					8.4772e-36	9.90997e-36	1	1	0	T	145580958	G	T	145580958	3	4	1	1	0	0	0	0	1	0	0	0	7132	1174	41	2	813	2	HHIP	4	145580958	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	34144395	145580958	45573318	15	15										
ASB5	140458	broad.mit.edu	37	chr4	177190223	177190223	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	aaagtagacattggataattGttgagcaaacggccgatttt	10	5	0	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr4:177190223G>T	ENST00000296525.3	-	1	150	c.37C>A	c.(37-39)Caa>Aaa	p.Q13K		NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	13					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TTGGATAATTGTTGAGCAAAC	0.423													28	40					3.73148e-12	3.92041e-12	1	1	0	T	177190223	G	T	177190223	3	4	1	1	0	0	0	0	1	0	0	0	1025	1386	48	5	980	5	ASB5	4	177190223	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	31609265	177190223	13964053	16	16										
IPO11	51194	broad.mit.edu	37	chr5	61733126	61733126	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	catggatctcaatagtgccaGcactgttgttcttcaggtgt	10	9	3	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr5:61733126G>T	ENST00000325324.6	+	2	189	c.20G>T	c.(19-21)aGc>aTc	p.S7I	IPO11_ENST00000409296.3_Missense_Mutation_p.S47I|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	7						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AATAGTGCCAGCACTGTTGTT	0.403													38	7					1.57019e-19	1.73768e-19	1	1	0	T	61733126	G	T	61733126	3	4	1	1	0	0	0	0	1	0	0	0	7836	971	34	5	146	5	IPO11	5	61733126	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		61733126	119182134	17	17										
PCDHA11	0	broad.mit.edu	37	chr5	140250487	140250487	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gcgcgcagtggatgcggactCaggctacaacgcgtggcttt	15	11	1	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr5:140250487C>T	ENST00000398640.2	+	1	1799	c.1799C>T	c.(1798-1800)tCa>tTa	p.S600L	PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGCGGACTCAGGCTACAAC	0.662													140	16					0	0	1	0	0	T	140250487	C	T	140250487	3	4	1	1	0	0	0	0	1	0	0	0	11567	838	29	3	1801	3	PCDHA11	5	140250487	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	78517361	140250487	40664773	18	18										
RNF182	221687	broad.mit.edu	37	chr6	13977863	13977863	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	tcacacaactggactgtgtgGaactgcacgtccctgctgtt	10	12	1	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr6:13977863G>T	ENST00000488300.1	+	3	1036	c.513G>T	c.(511-513)tgG>tgT	p.W171C	RNF182_ENST00000537663.1_Missense_Mutation_p.W171C|RNF182_ENST00000537388.1_Missense_Mutation_p.W171C|RNF182_ENST00000544682.1_Missense_Mutation_p.W171C	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	171						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			GGACTGTGTGGAACTGCACGT	0.517													51	144					9.22156e-22	1.04848e-21	1	1	0	T	13977863	G	T	13977863	3	4	1	1	0	0	0	0	1	0	0	0	13517	1183	41	2	515	2	RNF182	6	13977863	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		13977863	157137204	19	19										
NKAPL	222698	broad.mit.edu	37	chr6	28227369	28227369	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gtcgctctgggtcgcgagggCggctcccaagattccgcaac	14	14	1	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr6:28227369C>T	ENST00000343684.3	+	1	272	c.220C>T	c.(220-222)Cgg>Tgg	p.R74W		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	74										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						GTCGCGAGGGCGGCTCCCAAG	0.612													54	27					0	0	1	0	0	T	28227369	C	T	28227369	3	4	1	1	0	0	0	0	1	0	0	0	10486	759	27	1	222	1	NKAPL	6	28227369	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	14249506	28227369	142887698	20	20										
CLIC1	1192	broad.mit.edu	37	chr6	31701648	31701648	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	actgcctccagaaattcctcAatcttgttggtgtctgtgtg	9	10	3	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr6:31701648A>C	ENST00000375780.2	-	4	812	c.240T>G	c.(238-240)atT>atG	p.I80M	CLIC1_ENST00000375784.3_Missense_Mutation_p.I80M|CLIC1_ENST00000375779.2_Missense_Mutation_p.I80M|CLIC1_ENST00000395892.1_Missense_Mutation_p.I80M			O00299	CLIC1_HUMAN	chloride intracellular channel 1	80	Required for insertion into the membrane.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)|skin(1)	7						GAAATTCCTCAATCTTGTTGG	0.562													103	54					0	0	1	0	0	C	31701648	A	C	31701648	3	2	1	1	0	0	0	0	1	0	0	0	3548	126	5	4	501	4	CLIC1	6	31701648	Missense_Mutation	SNP	A	TCGA-N5-A4R8-01A-11D-A28R-08	3474279	31701648	139413419	21	21										
GJA1	2697	broad.mit.edu	37	chr6	121768821	121768821	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ggctgctcctcaccaaccgcTcccctctcgcctatgtctcc	6	21	3	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr6:121768821T>C	ENST00000282561.3	+	2	985	c.828T>C	c.(826-828)gcT>gcC	p.A276A		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	276					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CACCAACCGCTCCCCTCTCGC	0.512													17	55					0	0	1	0	0	C	121768821	T	C	121768821	2	2	1	1	0	0	0	0	0	0	0	1	6441	1538	54	4		4	GJA1	6	121768821	Silent	SNP	T	TCGA-N5-A4R8-01A-11D-A28R-08	90067173	121768821	49346246	22	22										
PHACTR2	9749	broad.mit.edu	37	chr6	144093533	144093533	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gccaatgactctgactcggaCgggcctatcttgtacaccga	10	13	2	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr6:144093533C>T	ENST00000427704.2	+	7	1468	c.1338C>T	c.(1336-1338)gaC>gaT	p.D446D	PHACTR2_ENST00000440869.2_Silent_p.D457D|PHACTR2_ENST00000367584.4_Silent_p.D434D|PHACTR2_ENST00000367582.3_Silent_p.D377D|PHACTR2_ENST00000305766.6_Silent_p.D366D	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	446							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CTGACTCGGACGGGCCTATCT	0.517													25	21					0	0	1	0	0	T	144093533	C	T	144093533	2	4	1	1	0	0	0	0	0	0	0	1	11857	535	19	1		1	PHACTR2	6	144093533	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	22324712	144093533	27021534	23	23										
SHPRH	257218	broad.mit.edu	37	chr6	146243850	146243850	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gacagactgttgcagactcaAtaacattacgagatggaggt	11	7	1	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr6:146243850A>G	ENST00000367503.3	-	19	4078	c.3680T>C	c.(3679-3681)aTt>aCt	p.I1227T	SHPRH_ENST00000438092.2_Missense_Mutation_p.I1227T|SHPRH_ENST00000275233.7_Missense_Mutation_p.I1223T|SHPRH_ENST00000367505.2_Missense_Mutation_p.I1223T	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1223					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGCAGACTCAATAACATTACG	0.413													47	21					0	0	1	0	0	G	146243850	A	G	146243850	3	3	1	1	0	0	0	0	1	0	0	0	14345	101	4	4	1448	4	SHPRH	6	146243850	Missense_Mutation	SNP	A	TCGA-N5-A4R8-01A-11D-A28R-08	2150317	146243850	24871217	24	24										
ZKSCAN1	7586	broad.mit.edu	37	chr7	99631178	99631178	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gagagaggtccaagggagaaGgggaaaggattgggaagaag	20	2	0	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr7:99631178G>C	ENST00000324306.6	+	6	1284	c.1050G>C	c.(1048-1050)aaG>aaC	p.K350N	ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.K314N|ZKSCAN1_ENST00000535170.1_Missense_Mutation_p.K137N	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	350					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CAAGGGAGAAGGGGAAAGGAT	0.473													15	23					0	0	1	0	0	C	99631178	G	C	99631178	3	2	1	1	0	0	0	0	1	0	0	0	17743	991	35	5	1068	5	ZKSCAN1	7	99631178	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		99631178	59507485	25	25										
MGAM	8972	broad.mit.edu	37	chr7	141736712	141736712	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	cgctatactctattgccctaCctatacaccctcttcttccg	3	17	3	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr7:141736712C>T	ENST00000475668.2	+	18	2220	c.2166C>T	c.(2164-2166)taC>taT	p.Y722Y	MGAM_ENST00000549489.2_Silent_p.Y722Y			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	722	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TATTGCCCTACCTATACACCC	0.507													94	44					0	0	1	0	0	T	141736712	C	T	141736712	2	4	1	1	0	0	0	0	0	0	0	1	9590	518	18	3		3	MGAM	7	141736712	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	42105534	141736712	17401951	26	26										
MYOM2	9172	broad.mit.edu	37	chr8	2021507	2021507	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	agccacctgcacaaggacgaCgagggcctgtacaccctgcg	12	15	0	0	rs144735881		TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr8:2021507C>T	ENST00000262113.4	+	10	1188	c.1047C>T	c.(1045-1047)gaC>gaT	p.D349D	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	349	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ACAAGGACGACGAGGGCCTGT	0.607													48	25					0	0	1	0	0	T	2021507	C	T	2021507	2	4	1	1	0	0	0	0	0	0	0	1	10139	535	19	1		1	MYOM2	8	2021507	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08		2021507	144342515	27	27										
RP1L1	94137	broad.mit.edu	37	chr8	10480144	10480144	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	caactgcttcacaggaaagcGcaggagatctgaggctttgc	12	10	2	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr8:10480144G>C	ENST00000382483.3	-	2	791	c.568C>G	c.(568-570)Cgc>Ggc	p.R190G	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	190					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		ACAGGAAAGCGCAGGAGATCT	0.512													111	81					0	0	1	0	0	C	10480144	G	C	10480144	3	2	1	1	0	0	0	0	1	0	0	0	13584	1087	38	5	6646	5	RP1L1	8	10480144	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	8458637	10480144	135883878	28	28										
TIGD5	84948	broad.mit.edu	37	chr8	144681482	144681482	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ctcctgggacctggtgcaggCgggcagcattgagcgctgct	16	12	0	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr8:144681482C>T	ENST00000504548.2	+	1	1409	c.1409C>T	c.(1408-1410)gCg>gTg	p.A470V	TIGD5_ENST00000321385.3_Missense_Mutation_p.A421V	NM_032862.4	NP_116251.4	E7EWS2	E7EWS2_HUMAN	tigger transposable element derived 5	470					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding			NS(1)|lung(3)|ovary(1)|soft_tissue(1)|urinary_tract(1)	7	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CTGGTGCAGGCGGGCAGCATT	0.706													11	17					0	0	1	0	0	T	144681482	C	T	144681482	3	4	1	1	0	0	0	0	1	0	0	0	15958	768	27	1	1411	1	TIGD5	8	144681482	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	134201338	144681482	1682540	29	29										
NFIB	4781	broad.mit.edu	37	chr9	14307309	14307309	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ctcctggcgaatatctttgcGcagtttggcaaggagcctgg	13	10	1	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr9:14307309G>A	ENST00000380959.3	-	2	714	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	NFIB_ENST00000380934.4_Missense_Mutation_p.R107C|NFIB_ENST00000380953.1_Missense_Mutation_p.R81C|NFIB_ENST00000380921.3_Missense_Mutation_p.R81C|NFIB_ENST00000397579.2_Missense_Mutation_p.R81C|NFIB_ENST00000397575.3_Missense_Mutation_p.R81C|NFIB_ENST00000397581.2_Missense_Mutation_p.R81C	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	81					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity	p.R81C(2)		central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ATATCTTTGCGCAGTTTGGCA	0.493			T	"MYB, HGMA2"	"adenoid cystic carcinoma, lipoma"								32	7					0	0	1	0	0	A	14307309	G	A	14307309	3	1	1	1	0	0	0	0	1	0	0	0	10417	1087	38	1	1053	1	NFIB	9	14307309	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		14307309	126906122	30	30										
NRAP	4892	broad.mit.edu	37	chr10	115402734	115402734	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	cttgctcacgttcctgaattGaggtgtttcacagtagttga	10	8	2	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr10:115402734G>A	ENST00000369358.4	-	12	1418	c.1174C>T	c.(1174-1176)Caa>Taa	p.Q392*	NRAP_ENST00000359988.3_Nonsense_Mutation_p.Q392*|NRAP_ENST00000369360.3_Intron|NRAP_ENST00000360478.3_Intron			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	392						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TTCCTGAATTGAGGTGTTTCA	0.408													21	66					0	0	1	0	0	A	115402734	G	A	115402734	4	1	1	1	0	0	0	0	0	1	0	0	10685	1299	45	3	4142	3	NRAP	10	115402734	Nonsense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		115402734	20132013	31	31										
ATE1	11101	broad.mit.edu	37	chr10	123503221	123503236	+	Frame_Shift_Del	DEL	CGGAGCACTTCTGCCC	CGGAGCACTTCTGCCC	-													0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	tctgaacagcagcatccgctCggagcacttctgccccacca					rs146965571	byFrequency	TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr10:123503221_123503236delCGGAGCACTTCTGCCC	ENST00000369043.3	-	12	1602_1617	c.1516_1531delGGGCAGAAGTGCTCCG	c.(1516-1533)agfs	p.GQKCSE506fs	ATE1_ENST00000369040.3_Frame_Shift_Del_p.GQKCSE410fs|ATE1_ENST00000535655.1_Frame_Shift_Del_p.GQKCSE207fs|ATE1_ENST00000224652.6_Frame_Shift_Del_p.GQKCSE506fs|ATE1_ENST00000540606.1_Frame_Shift_Del_p.GQKCSE499fs|ATE1_ENST00000543447.1_Frame_Shift_Del_p.GQKCSE391fs	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	506					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				AGCATCCGCTCGGAGCACTTCTGCCCCACCAGGCTG	0.519													14	50	---	---	---	---						-	123503236	CGGAGCACTTCTGCCC	-	123503221	7	5	1	1	0	1	0	1	0	0	0	0	1077	893	31	0	29	0	ATE1	10	123503221	Frame_Shift_Del	DEL	CGGAGCACTTCTGCCC	TCGA-N5-A4R8-01A-11D-A28R-08	8100487	123503221	12031526	32	32										
AHNAK	79026	broad.mit.edu	37	chr11	62293798	62293798	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gctttgatattcatctctggCatcttgaacttaggcccttt	7	10	3	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr11:62293798C>A	ENST00000378024.4	-	5	8365	c.8091G>T	c.(8089-8091)atG>atT	p.M2697I	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2697					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCATCTCTGGCATCTTGAACT	0.458													145	77					5.4523e-64	6.46487e-64	1	1	0	A	62293798	C	A	62293798	3	1	1	1	0	0	0	0	1	0	0	0	411	710	25	5	9701	5	AHNAK	11	62293798	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08		62293798	72712718	33	33										
RAD9A	5883	broad.mit.edu	37	chr11	67164804	67164804	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gccccggtccccactccgagGaggaagatgaggctgagccc	14	15	0	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr11:67164804G>C	ENST00000307980.2	+	10	1120	c.1027G>C	c.(1027-1029)Gag>Cag	p.E343Q	RAD9A_ENST00000535644.1_3'UTR	NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	343	Sufficient for interaction with ABL1.				DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding			lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			CCACTCCGAGGAGGAAGATGA	0.642								Other conserved DNA damage response genes					4	12					0	0	1	0	0	C	67164804	G	C	67164804	3	2	1	1	0	0	0	0	1	0	0	0	13046	1175	41	2	1065	2	RAD9A	11	67164804	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	4871006	67164804	67841712	34	34										
AKAP3	10566	broad.mit.edu	37	chr12	4737296	4737296	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ctcccgaggaaagaaccttcCaccctctctggcataatctc	6	16	2	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr12:4737296C>A	ENST00000545990.2	-	5	1296	c.772G>T	c.(772-774)Gga>Tga	p.G258*	AKAP3_ENST00000228850.1_Nonsense_Mutation_p.G258*	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	258					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						AAGAACCTTCCACCCTCTCTG	0.458													33	188					2.81731e-10	2.92296e-10	1	1	0	A	4737296	C	A	4737296	4	1	1	1	0	0	0	0	0	1	0	0	449	603	21	5	1797	5	AKAP3	12	4737296	Nonsense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08		4737296	129114599	35	35										
KLRB1	3820	broad.mit.edu	37	chr12	9760429	9760429	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ctcagcatatattgcttgttGgtccatggcagacagaggaa	11	8	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr12:9760429G>T	ENST00000229402.3	-	1	53	c.7C>A	c.(7-9)Caa>Aaa	p.Q3K		NM_002258.2	NP_002249.1	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B, member 1	3					cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|large_intestine(6)|lung(4)	12						ATTGCTTGTTGGTCCATGGCA	0.438													42	81					8.01111e-26	9.23503e-26	1	1	0	T	9760429	G	T	9760429	3	4	1	1	0	0	0	0	1	0	0	0	8456	1357	47	5	693	5	KLRB1	12	9760429	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	5023133	9760429	124091466	36	36										
SLC25A3	5250	broad.mit.edu	37	chr12	98987870	98987870	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	agctccccagggcccacgggCcagccccgccgccctcgcaa	11	22	0	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr12:98987870C>G	ENST00000188376.5	+	1	468	c.114C>G	c.(112-114)ggC>ggG	p.G38G	SLC25A3_ENST00000551917.1_Silent_p.G38G|SLC25A3_ENST00000551265.1_Silent_p.G38G|SLC25A3_ENST00000549338.1_Silent_p.G38G|SLC25A3_ENST00000548847.1_Silent_p.G38G|SLC25A3_ENST00000552981.1_Silent_p.G38G|SLC25A3_ENST00000547534.1_Silent_p.G38G|SLC25A3_ENST00000228318.3_Silent_p.G38G|SLC25A3_ENST00000401722.3_Silent_p.G38G	NM_002635.3|NM_213611.2	NP_002626.1|NP_998776.1	Q00325	MPCP_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	38					generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(8)|prostate(1)	16		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		GGCCCACGGGCCAGCCCCGCC	0.697													14	31					0	0	1	0	0	G	98987870	C	G	98987870	2	3	1	1	0	0	0	0	0	0	0	1	14547	726	26	5		5	SLC25A3	12	98987870	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	89227441	98987870	34864025	37	37										
DACH1	1602	broad.mit.edu	37	chr13	72204835	72204835	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	agcagcagcagctgctgcagCggctgctgtcagaccttaaa	12	12	1	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr13:72204835C>G	ENST00000305425.4	-	3	1407	c.985G>C	c.(985-987)Gct>Cct	p.A329P	DACH1_ENST00000354591.4_Intron|DACH1_ENST00000359684.2_Missense_Mutation_p.A329P|DACH1_ENST00000313174.7_Missense_Mutation_p.A329P	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	327	Interaction with SIX6 and HDAC3 (By similarity).|Poly-Ala.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		gctgctgcagcggctgcTGTC	0.358													42	82					0	0	1	0	0	G	72204835	C	G	72204835	3	3	1	1	0	0	0	0	1	0	0	0	4244	768	27	5	1177	5	DACH1	13	72204835	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08		72204835	42965043	38	38										
FLVCR2	55640	broad.mit.edu	37	chr14	76091051	76091051	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	atacttaggttccatcgcccGgctcttcaaaaatctcaact	5	13	3	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr14:76091051G>A	ENST00000238667.4	+	3	1264	c.908G>A	c.(907-909)cGg>cAg	p.R303Q	FLVCR2_ENST00000556241.1_3'UTR|FLVCR2_ENST00000553587.1_Missense_Mutation_p.R51Q|FLVCR2_ENST00000539311.1_Missense_Mutation_p.R98Q|FLVCR2_ENST00000556856.1_Missense_Mutation_p.R51Q	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	303					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		TCCATCGCCCGGCTCTTCAAA	0.483													83	2					0	0	1	0	0	A	76091051	G	A	76091051	3	1	1	1	0	0	0	0	1	0	0	0	5978	1116	39	1	918	1	FLVCR2	14	76091051	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		76091051	31258489	39	39										
TPSG1	25823	broad.mit.edu	37	chr16	1271916	1271916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	agccaggagggggagcctggGgtacccagactctgagcccc	16	13	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr16:1271916G>A	ENST00000234798.4	-	6	842	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	280					proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				GGGAGCCTGGGGTACCCAGAC	0.652													20	20					0	0	1	0	0	A	1271916	G	A	1271916	3	1	1	1	0	0	0	0	1	0	0	0	16486	1232	43	3	131	3	TPSG1	16	1271916	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		1271916	89082837	40	40										
PPL	5493	broad.mit.edu	37	chr16	4944606	4944606	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gcagggtgtagctgtagcccCgcgagatcaggccctggcgg	17	12	1	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr16:4944606C>T	ENST00000345988.2	-	12	1345	c.1256G>A	c.(1255-1257)cGg>cAg	p.R419Q	PPL_ENST00000590782.2_Missense_Mutation_p.R417Q	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	419					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GCTGTAGCCCCGCGAGATCAG	0.647													24	35					0	0	1	0	0	T	4944606	C	T	4944606	3	4	1	1	0	0	0	0	1	0	0	0	12382	652	23	1	4058	1	PPL	16	4944606	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	3672690	4944606	85410147	41	41										
ANKS4B	257629	broad.mit.edu	37	chr16	21261508	21261508	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	attaaagacactttcaagatCaagttcaagaagaacaaaga	6	6	3	5			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr16:21261508C>A	ENST00000311620.5	+	2	694	c.621C>A	c.(619-621)atC>atA	p.I207I		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	207										NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		CTTTCAAGATCAAGTTCAAGA	0.473													3	42					1	1	1	1	0	A	21261508	C	A	21261508	2	1	1	1	0	0	0	0	0	0	0	1	685	816	29	2		2	ANKS4B	16	21261508	Silent	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	16316902	21261508	69093245	42	42										
SIAH1	6477	broad.mit.edu	37	chr16	48395912	48395912	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gcatcagatggggcattacaGcatccagagagccttgccat	11	11	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr16:48395912G>A	ENST00000380006.2	-	1	1881	c.428C>T	c.(427-429)gCt>gTt	p.A143V	SIAH1_ENST00000356721.3_Missense_Mutation_p.A174V|SIAH1_ENST00000394725.2_Missense_Mutation_p.A143V			Q8IUQ4	SIAH1_HUMAN	siah E3 ubiquitin protein ligase 1	143	SBD.				axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|stomach(1)	7		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				GGGCATTACAGCATCCAGAGA	0.468													3	41					0	0	1	0	0	A	48395912	G	A	48395912	3	1	1	1	0	0	0	0	1	0	0	0	14353	971	34	3	424	3	SIAH1	16	48395912	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	27134404	48395912	41958841	43	43										
USP10	9100	broad.mit.edu	37	chr16	84801887	84801887	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	atatccagtcagacaagataCgcacagtccaggatgcactg	9	11	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr16:84801887C>T	ENST00000219473.7	+	11	2034	c.1921C>T	c.(1921-1923)Cgc>Tgc	p.R641C	USP10_ENST00000570191.1_Missense_Mutation_p.R645C	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	641					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						AGACAAGATACGCACAGTCCA	0.428													10	7					0	0	1	0	0	T	84801887	C	T	84801887	3	4	1	1	0	0	0	0	1	0	0	0	17100	536	19	1	1963	1	USP10	16	84801887	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	36405975	84801887	5552866	44	44										
TP53	7157	broad.mit.edu	37	chr17	7578291	7578291	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	tgctgaggaggggccagaccTaagagcaatcagtgaggaat	15	7	1	4			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr17:7578291T>G	ENST00000420246.2	-	6	692		c.e6-2		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(8)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGCCAGACCTAAGAGCAATC	0.552		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			58	6					0	0	1	0	0	G	7578291	T	G	7578291	5	3	1	1	0	0	0	0	0	0	1	0	16441	1536	53	4	736	4	TP53	17	7578291	Splice_Site	SNP	T	TCGA-N5-A4R8-01A-11D-A28R-08		7578291	73616919	45	45										
EFNB3	1949	broad.mit.edu	37	chr17	7611523	7611523	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	tccaggagtatagccctaatCtctggggccacgagttccgc	11	13	1	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr17:7611523C>G	ENST00000226091.2	+	2	767	c.370C>G	c.(370-372)Ctc>Gtc	p.L124V		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	124					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TAGCCCTAATCTCTGGGGCCA	0.577													44	115					0	0	1	0	0	G	7611523	C	G	7611523	3	3	1	1	0	0	0	0	1	0	0	0	4983	913	32	2	376	2	EFNB3	17	7611523	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	33232	7611523	73583687	46	46										
DNAH2	146754	broad.mit.edu	37	chr17	7671536	7671536	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	caaaaatagagcagttcaagAggaccatgcctctcatctca	7	11	3	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr17:7671536A>G	ENST00000572933.1	+	24	5352	c.3892A>G	c.(3892-3894)Agg>Ggg	p.R1298G	DNAH2_ENST00000389173.2_Missense_Mutation_p.R1298G			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1298	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCAGTTCAAGAGGACCATGCC	0.572													118	85					0	0	1	0	0	G	7671536	A	G	7671536	3	3	1	1	0	0	0	0	1	0	0	0	4630	295	11	4	3982	4	DNAH2	17	7671536	Missense_Mutation	SNP	A	TCGA-N5-A4R8-01A-11D-A28R-08	60013	7671536	73523674	47	47										
KRTAP3-1	83896	broad.mit.edu	37	chr17	39165215	39165215	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ctgaaggaggctgatctcatGtgggcaggtgctgggtaggc	18	7	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr17:39165215G>T	ENST00000391588.1	-	1	151	c.112C>A	c.(112-114)Cat>Aat	p.H38N	KRTAP3-1_ENST00000581033.1_5'UTR	NM_031958.1	NP_114164.1	Q9BYR8	KRA31_HUMAN	keratin associated protein 3-1	38	4 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	8		Breast(137;0.00043)				CTGATCTCATGTGGGCAGGTG	0.602													28	86					5.61819e-17	6.13565e-17	1	1	0	T	39165215	G	T	39165215	3	4	1	1	0	0	0	0	1	0	0	0	8588	1377	48	5	188	5	KRTAP3-1	17	39165215	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	31493679	39165215	42029995	48	48										
PSME3	10197	broad.mit.edu	37	chr17	40990780	40990780	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gtacagctcctgattcccagGatagaagatggaaacaactt	9	9	0	3			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr17:40990780G>C	ENST00000293362.3	+	7	638	c.477G>C	c.(475-477)agG>agC	p.R159S	PSME3_ENST00000545225.1_Missense_Mutation_p.R85S|PSME3_ENST00000590720.1_Missense_Mutation_p.R146S|PSME3_ENST00000441946.2_Missense_Mutation_p.R157S|PSME3_ENST00000592169.1_Missense_Mutation_p.R90S|PSME3_ENST00000541124.1_3'UTR	NM_005789.3|NM_176863.2	NP_005780.2|NP_789839.1	P61289	PSME3_HUMAN	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	146					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome activator complex	endopeptidase activator activity|identical protein binding|MDM2 binding|p53 binding			NS(1)|cervix(1)|large_intestine(3)|lung(1)	6		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TGATTCCCAGGATAGAAGATG	0.458													51	45					0	0	1	0	0	C	40990780	G	C	40990780	3	2	1	1	0	0	0	0	1	0	0	0	12756	1165	41	2	503	2	PSME3	17	40990780	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	1825565	40990780	40204430	49	49										
CCDC57	284001	broad.mit.edu	37	chr17	80141803	80141803	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ttacagttgatgcatcttcaCgaagtctaaacatagaaggg	9	7	3	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr17:80141803C>T	ENST00000392347.1	-	8	1094	c.1058G>A	c.(1057-1059)cGt>cAt	p.R353H	CCDC57_ENST00000389641.4_Missense_Mutation_p.R353H|CCDC57_ENST00000392343.3_Missense_Mutation_p.R353H|CCDC57_ENST00000327026.3_5'UTR	NM_198082.2	NP_932348.2	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	353										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TGCATCTTCACGAAGTCTAAA	0.468													17	23					0	0	1	0	0	T	80141803	C	T	80141803	3	4	1	1	0	0	0	0	1	0	0	0	2847	536	19	1	1729	1	CCDC57	17	80141803	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	39151023	80141803	1053407	50	50										
CALR	811	broad.mit.edu	37	chr19	13049506	13049506	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	ggcccgccatgctgctatccGtgccgctgctgctcggcctc	12	18	0	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr19:13049506G>A	ENST00000316448.5	+	1	86	c.13G>A	c.(13-15)Gtg>Atg	p.V5M		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	5					cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGCTATCCGTGCCGCTGCT	0.711											OREG0025278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	10					0	0	1	0	0	A	13049506	G	A	13049506	3	1	1	1	0	0	0	0	1	0	0	0	2610	1145	40	1	15	1	CALR	19	13049506	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		13049506	46079477	51	51										
LAMA5	3911	broad.mit.edu	37	chr20	60913126	60913126	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gcaccggtcacaatgaggtcCagcaaactcaggctggcata	11	12	2	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chr20:60913126C>A	ENST00000252999.3	-	14	1903	c.1837G>T	c.(1837-1839)Gga>Tga	p.G613*		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	613	Laminin EGF-like 6.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAATGAGGTCCAGCAAACTCA	0.652													42	13					4.44401e-20	4.9845e-20	1	1	0	A	60913126	C	A	60913126	4	1	1	1	0	0	0	0	0	1	0	0	8647	603	21	5	9518	5	LAMA5	20	60913126	Nonsense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08		60913126	2112394	52	52										
PRAF2	11230	broad.mit.edu	37	chrX	48929638	48929638	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	aatcttgttcttaaggttgcGcaggcgcaacgaggcgtgca	13	9	2	0			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:48929638G>A	ENST00000376390.4	-	3	510	c.427C>T	c.(427-429)Cgc>Tgc	p.R143C	WDR45_ENST00000376358.3_Missense_Mutation_p.R257C|WDR45_ENST00000553851.1_Missense_Mutation_p.R257C|PRAF2_ENST00000491199.1_5'UTR	NM_007213.1	NP_009144.1			PRA1 domain family, member 2											endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	8						TTAAGGTTGCGCAGGCGCAAC	0.602													26	34					0	0	1	0	0	A	48929638	G	A	48929638	3	1	1	1	0	0	0	0	1	0	0	0	12470	1087	38	1	113	1	PRAF2	23	48929638	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08		48929638	106340922	53	53										
NUDT10	170685	broad.mit.edu	37	chrX	51076024	51076024	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gtccgagaggtgtacgaagaGgcgggagtcaaggggaagtt	19	5	1	2	rs143435240	byFrequency	TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657													4	48					0	0	1	0	0	A	51076024	G	A	51076024	2	1	1	1	0	0	0	0	0	0	0	1	10773	991	35	3		3	NUDT10	23	51076024	Silent	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	2146386	51076024	104194536	54	54										
PHF8	23133	broad.mit.edu	37	chrX	54011405	54011407	+	In_Frame_Del	DEL	CTC	CTC	-													0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	tgttcatccagactggcgttCtcctcctcctcctcgctctc							TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:54011405_54011407delCTC	ENST00000338154.6	-	18	2887_2889	c.2383_2385delGAG	c.(2383-2385)del	p.E795del	PHF8_ENST00000338946.6_In_Frame_Del_p.E694del|PHF8_ENST00000322659.8_In_Frame_Del_p.E778del|PHF8_ENST00000357988.5_In_Frame_Del_p.E831del	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	831	Ser-rich.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						GACTGGCGTTCTCCTCCTCCTCC	0.591													8	150	---	---	---	---						-	54011407	CTC	-	54011405	7	5	1	1	0	1	0	1	0	0	0	0	11887	912	32	0	835	0	PHF8	23	54011405	In_Frame_Del	DEL	CTC	TCGA-N5-A4R8-01A-11D-A28R-08	2935381	54011405	101259155	55	55										
HEPH	9843	broad.mit.edu	37	chrX	65418862	65418862	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gggcttccaagactccaatcGgatgcatggtatggggagta	14	8	0	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:65418862G>A	ENST00000519389.1	+	11	2197	c.2018G>A	c.(2017-2019)cGg>cAg	p.R673Q	HEPH_ENST00000419594.1_Intron|HEPH_ENST00000374727.3_Missense_Mutation_p.R622Q|HEPH_ENST00000441993.2_Missense_Mutation_p.R622Q|HEPH_ENST00000336279.5_Missense_Mutation_p.R352Q|HEPH_ENST00000343002.2_Missense_Mutation_p.R619Q			Q9BQS7	HEPH_HUMAN	hephaestin	619	Plastocyanin-like 4.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GACTCCAATCGGATGCATGGT	0.448													42	47					0	0	1	0	0	A	65418862	G	A	65418862	3	1	1	1	0	0	0	0	1	0	0	0	7094	1116	39	1	2060	1	HEPH	23	65418862	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	11407457	65418862	89851698	56	56										
SLC7A3	84889	broad.mit.edu	37	chrX	70148385	70148385	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	gttgtgcacgtcccccttaaCgaagccagagatcatgacga	10	12	1	2			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:70148385C>T	ENST00000374299.3	-	4	772	c.628G>A	c.(628-630)Gtt>Att	p.V210I	SLC7A3_ENST00000298085.4_Missense_Mutation_p.V210I			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	210					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCCCCCTTAACGAAGCCAGAG	0.507													9	6					0	0	1	0	0	T	70148385	C	T	70148385	3	4	1	1	0	0	0	0	1	0	0	0	14752	536	19	1	1267	1	SLC7A3	23	70148385	Missense_Mutation	SNP	C	TCGA-N5-A4R8-01A-11D-A28R-08	4729523	70148385	85122175	57	57										
TRMT2B	79979	broad.mit.edu	37	chrX	100278581	100278581	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	aaggcagggctccaatggagActgtcgaaggaatacttcat	12	8	1	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:100278581A>G	ENST00000338687.7	-	7	1304	c.499T>C	c.(499-501)Tct>Cct	p.S167P	TRMT2B_ENST00000478422.1_5'UTR|TRMT2B_ENST00000372939.1_Missense_Mutation_p.S167P|TRMT2B_ENST00000372935.1_Missense_Mutation_p.S212P|TRMT2B_ENST00000372931.5_Missense_Mutation_p.S212P|TRMT2B_ENST00000372936.3_Missense_Mutation_p.S212P|TRMT2B_ENST00000545398.1_Missense_Mutation_p.S212P			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	212							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						TCCAATGGAGACTGTCGAAGG	0.443													32	26					0	0	1	0	0	G	100278581	A	G	100278581	3	3	1	1	0	0	0	0	1	0	0	0	16626	275	10	4	908	4	TRMT2B	23	100278581	Missense_Mutation	SNP	A	TCGA-N5-A4R8-01A-11D-A28R-08	30130196	100278581	54991979	58	58										
NRK	203447	broad.mit.edu	37	chrX	105153215	105153215	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0677966101694915	4	1	0.878980891719745	0.988853503184713	0.847588717015469	0.523809523809524	1	0	agggtcaagatcaggtacccGaacaacaaaggcagggccag	13	10	2	1			TCGA-N5-A4R8-01A-11D-A28R-08	TCGA-N5-A4R8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cfe9c-405b-4e39-a4c1-a68ea61dfc6a	2204ecdd-1591-4ebf-ad83-6ec1fc3e9053	g.chrX:105153215G>A	ENST00000428173.2	+	13	1888	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	NRK_ENST00000243300.9_Missense_Mutation_p.E528K			Q7Z2Y5	NRK_HUMAN	Nik related kinase	528	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TCAGGTACCCGAACAACAAAG	0.552										HNSCC(51;0.14)			26	22					0	0	1	0	0	A	105153215	G	A	105153215	3	1	1	1	0	0	0	0	1	0	0	0	10702	1059	37	1	1632	1	NRK	23	105153215	Missense_Mutation	SNP	G	TCGA-N5-A4R8-01A-11D-A28R-08	4874634	105153215	50117345	59	59										
CDK11B	984	broad.mit.edu	37	chr1	1572453	1572453	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gggggctcaccttgaggatgCcggcgtggctcagcagcagg	18	11	2	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr1:1572453C>T	ENST00000407249.3	-	16	1690	c.1691G>A	c.(1690-1692)gGc>gAc	p.G564D	CDK11B_ENST00000340677.5_Missense_Mutation_p.G551D|CDK11B_ENST00000341832.6_Missense_Mutation_p.G517D|CDK11B_ENST00000317673.7_Missense_Mutation_p.G562D			P21127	CD11B_HUMAN	cyclin-dependent kinase 11B	574	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			endometrium(2)|large_intestine(3)|lung(4)|skin(1)|stomach(2)	12						CTTGAGGATGCCGGCGTGGCT	0.647													4	152					0	0	1	0	0	T	1572453	C	T	1572453	3	4	2	1	0	0	0	0	1	0	0	0	3149	739	26	3	690	3	CDK11B	1	1572453	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		1572453	247678168	1	60										
HSPB7	27129	broad.mit.edu	37	chr1	16342195	16342195	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtcaccgacgtcgggtccacGtcctccggcagctggcactt	12	16	1	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr1:16342195G>A	ENST00000311890.9	-	3	1219	c.393C>T	c.(391-393)gaC>gaT	p.D131D	HSPB7_ENST00000411503.1_Silent_p.D126D|HSPB7_ENST00000406363.2_Silent_p.D135D|HSPB7_ENST00000375718.4_Silent_p.D206D|HSPB7_ENST00000487046.1_Silent_p.D136D	NM_014424.4	NP_055239.1	Q9UBY9	HSPB7_HUMAN	heat shock 27kDa protein family, member 7 (cardiovascular)	131					regulation of heart contraction|response to heat|response to unfolded protein	Cajal body	protein C-terminus binding			breast(1)|large_intestine(1)|liver(1)|lung(6)|skin(1)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.21e-08)|COAD - Colon adenocarcinoma(227;5.5e-06)|BRCA - Breast invasive adenocarcinoma(304;9.08e-05)|Kidney(64;0.000162)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		TCGGGTCCACGTCCTCCGGCA	0.677													72	48					0	0	1	0	0	A	16342195	G	A	16342195	2	1	2	1	0	0	0	0	0	0	0	1	7465	1136	40	1		1	HSPB7	1	16342195	Silent	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	14769742	16342195	232908426	2	61										
ZBTB7B	51043	broad.mit.edu	37	chr1	154987765	154987765	+	Frame_Shift_Del	DEL	A	A	-													0	0	1	0	0	0	1	1	0	gccccggaaagctttcctgcAaaccaagggggccagagcaa							TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr1:154987765delA	ENST00000368426.3	+	3	766	c.629delA	c.(628-630)cafs	p.Q210fs	ZBTB7B_ENST00000292176.2_Frame_Shift_Del_p.Q210fs|ZBTB7B_ENST00000535420.1_Frame_Shift_Del_p.Q210fs|ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000417934.2_Frame_Shift_Del_p.Q244fs	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	210					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTTTCCTGCAAACCAAGGGG	0.672													114	228	---	---	---	---						-	154987765	A	-	154987765	7	5	2	1	0	1	0	1	0	0	0	0	17612	130	5	0	631	0	ZBTB7B	1	154987765	Frame_Shift_Del	DEL	A	TCGA-N5-A4RA-01A-11D-A28R-08	138645570	154987765	94262856	3	62										
LAMC1	3915	broad.mit.edu	37	chr1	182993005	182993018	+	Frame_Shift_Del	DEL	CCCGAGTTCGTCAA	CCCGAGTTCGTCAA	-													0	0	1	0	0	0	1	1	0	ggcggccgcagcgctgcatgCccgagttcgtcaacgccgcc							TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr1:182993005_182993018delCCCGAGTTCGTCAA	ENST00000258341.4	+	1	411_424	c.154_167delCCCGAGTTCGTCAA	c.(154-168)cfs	p.PEFVN52fs		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	52	Laminin N-terminal.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGCTGCATGCCCGAGTTCGTCAACGCCGCCTTC	0.71													8	55	---	---	---	---						-	182993018	CCCGAGTTCGTCAA	-	182993005	7	5	2	1	0	1	0	1	0	0	0	0	8652	739	26	0	156	0	LAMC1	1	182993005	Frame_Shift_Del	DEL	CCCGAGTTCGTCAA	TCGA-N5-A4RA-01A-11D-A28R-08	28005240	182993005	66257616	4	63										
USH2A	7399	broad.mit.edu	37	chr1	216595499	216595499	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	caaaaagtgcttcggtctggGagtccacatactgcttgggt	12	9	1	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr1:216595499G>A	ENST00000366943.2	-	2	566	c.180C>T	c.(178-180)ctC>ctT	p.L60L	USH2A_ENST00000307340.3_Silent_p.L60L|USH2A_ENST00000366942.3_Silent_p.L60L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	60					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCGGTCTGGGAGTCCACATA	0.483										HNSCC(13;0.011)			37	28					0	0	1	0	0	A	216595499	G	A	216595499	2	1	2	1	0	0	0	0	0	0	0	1	17095	1161	41	3		3	USH2A	1	216595499	Silent	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	33602494	216595499	32655122	5	64										
ITSN2	50618	broad.mit.edu	37	chr2	24438918	24438918	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aaggcccagaatggaattacCtttaaaaattctttgaaatc	6	7	1	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr2:24438918C>T	ENST00000355123.4	-	32	4433	c.3990_splice	c.e32+1	p.K1330_splice	ITSN2_ENST00000361999.3_Splice_Site_p.K1303_splice|AC009228.1_ENST00000413254.1_RNA|AC009228.1_ENST00000413989.1_RNA|AC009228.1_ENST00000430105.1_RNA	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1330	DH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGGAATTACCTTTAAAAATT	0.498													35	26					0	0	1	0	0	T	24438918	C	T	24438918	5	4	2	1	0	0	0	0	0	0	1	0	7970	695	24	3	1139	3	ITSN2	2	24438918	Splice_Site	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		24438918	218760455	6	65										
SMYD1	150572	broad.mit.edu	37	chr2	88390583	88390583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gagaggcctgcaggccgtggGcgtaggcatcttccccaacc	14	14	1	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr2:88390583G>A	ENST00000419482.2	+	4	666	c.581G>A	c.(580-582)gGc>gAc	p.G194D	SMYD1_ENST00000438570.1_Intron|SMYD1_ENST00000444564.2_Missense_Mutation_p.G194D	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	194	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						CAGGCCGTGGGCGTAGGCATC	0.498													65	176					0	0	1	0	0	A	88390583	G	A	88390583	3	1	2	1	0	0	0	0	1	0	0	0	14874	1203	42	3	595	3	SMYD1	2	88390583	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	63951665	88390583	154808790	7	66										
SCN1A	6323	broad.mit.edu	37	chr2	166908389	166908389	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttcctcaggttgcccatgaaCagctgcagcccaattagagc	9	13	1	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr2:166908389C>T	ENST00000423058.2	-	6	821	c.804G>A	c.(802-804)ctG>ctA	p.L268L	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.L268L|SCN1A_ENST00000303395.4_Silent_p.L268L|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Silent_p.L268L	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	268						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGCCCATGAACAGCTGCAGCC	0.433													25	79					0	0	1	0	0	T	166908389	C	T	166908389	2	4	2	1	0	0	0	0	0	0	0	1	13967	465	17	3		3	SCN1A	2	166908389	Silent	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	78517806	166908389	76290984	8	67										
HOXD12	3238	broad.mit.edu	37	chr2	176964703	176964703	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gccgccacgcccgcctcctgCgcccccgcgcagcctgcggg	13	23	0	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr2:176964703C>T	ENST00000406506.2	+	1	246	c.174C>T	c.(172-174)tgC>tgT	p.C58C	HOXD12_ENST00000404162.2_Silent_p.C58C			P35452	HXD12_HUMAN	homeobox D12	58						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(7)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CCGCCTCCTGCGCCCCCGCGC	0.741													7	30					0	0	1	0	0	T	176964703	C	T	176964703	2	4	2	1	0	0	0	0	0	0	0	1	7361	776	27	1		1	HOXD12	2	176964703	Silent	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	10056314	176964703	66234670	9	68										
TSEN2	80746	broad.mit.edu	37	chr3	12531391	12531391	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aatcccttttggtcaggaccAtggtcctctgaaagaattca	8	10	3	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr3:12531391A>G	ENST00000444864.1	+	2	479	c.92A>G	c.(91-93)cAt>cGt	p.H31R	TSEN2_ENST00000454502.2_Missense_Mutation_p.H31R|TSEN2_ENST00000415684.1_Missense_Mutation_p.H31R|TSEN2_ENST00000383797.5_Missense_Mutation_p.H31R|TSEN2_ENST00000314571.7_Missense_Mutation_p.H31R|TSEN2_ENST00000284995.6_Missense_Mutation_p.H31R|TSEN2_ENST00000402228.3_Missense_Mutation_p.H31R	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	31					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						GGTCAGGACCATGGTCCTCTG	0.433													30	67					0	0	1	0	0	G	12531391	A	G	12531391	3	3	2	1	0	0	0	0	1	0	0	0	16672	217	8	4	94	4	TSEN2	3	12531391	Missense_Mutation	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08		12531391	185491039	10	69										
CD86	942	broad.mit.edu	37	chr3	121825307	121825307	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	accatcttctgtattctggaAactgacaagacgcggctttt	8	10	3	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr3:121825307A>C	ENST00000330540.2	+	4	779	c.663A>C	c.(661-663)gaA>gaC	p.E221D	CD86_ENST00000393627.2_Missense_Mutation_p.E215D|CD86_ENST00000493101.1_Missense_Mutation_p.E109D|CD86_ENST00000264468.5_Intron|CD86_ENST00000469710.1_Missense_Mutation_p.E139D	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	221	Ig-like C2-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	GTATTCTGGAAACTGACAAGA	0.388													47	153					0	0	1	0	0	C	121825307	A	C	121825307	3	2	2	1	0	0	0	0	1	0	0	0	3065	11	1	4	677	4	CD86	3	121825307	Missense_Mutation	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08	109293916	121825307	76197123	11	70										
KALRN	8997	broad.mit.edu	37	chr3	124418865	124418865	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gcgagccctcggagtttgtgCgacttccagaatatggtgag	14	9	0	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr3:124418865C>T	ENST00000360013.3	+	56	8108	c.7981C>T	c.(7981-7983)Cga>Tga	p.R2661*	KALRN_ENST00000428018.2_Nonsense_Mutation_p.R932*|KALRN_ENST00000291478.4_Nonsense_Mutation_p.R964*	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2660					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGAGTTTGTGCGACTTCCAGA	0.597													4	211					0	0	1	0	0	T	124418865	C	T	124418865	4	4	2	1	0	0	0	0	0	1	0	0	8018	760	27	1	8359	1	KALRN	3	124418865	Nonsense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	2593558	124418865	73603565	12	71										
PODXL2	50512	broad.mit.edu	37	chr3	127358250	127358250	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	agctgggctgggagcccctgGctcaggcttccccagcgaag	15	14	1	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr3:127358250G>T	ENST00000342480.6	+	2	272	c.233G>T	c.(232-234)gGc>gTc	p.G78V		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	78					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						GGAGCCCCTGGCTCAGGCTTC	0.597													30	46					5.45727e-16	6.4495e-16	1	1	0	T	127358250	G	T	127358250	3	4	2	1	0	0	0	0	1	0	0	0	12228	1203	42	5	239	5	PODXL2	3	127358250	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	2939385	127358250	70664180	13	72										
CLCN2	1181	broad.mit.edu	37	chr3	184073266	184073266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctcctccaccaggccctggcGgacccacgtccgattgtcaa	9	18	1	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr3:184073266G>A	ENST00000265593.4	-	12	1393	c.1222C>T	c.(1222-1224)Cgc>Tgc	p.R408C	EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000457512.1_Missense_Mutation_p.R408C|CLCN2_ENST00000423355.2_Missense_Mutation_p.R49C|CLCN2_ENST00000475279.1_5'UTR|CLCN2_ENST00000344937.7_Missense_Mutation_p.R408C|CLCN2_ENST00000434054.2_Missense_Mutation_p.R364C	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	408						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	AGGCCCTGGCGGACCCACGTC	0.582													59	83					0	0	1	0	0	A	184073266	G	A	184073266	3	1	2	1	0	0	0	0	1	0	0	0	3486	1116	39	1	1526	1	CLCN2	3	184073266	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	56715016	184073266	13949164	14	73										
FBXW7	0	broad.mit.edu	37	chr4	153250873	153250873	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aagtgttgtcatcagaaccaCtaactattcggttaccacaa	6	10	2	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr4:153250873C>T	ENST00000281708.4	-	8	2416	c.1187G>A	c.(1186-1188)aGt>aAt	p.S396N	FBXW7_ENST00000263981.5_Missense_Mutation_p.S316N|FBXW7_ENST00000603548.1_Missense_Mutation_p.S396N|FBXW7_ENST00000296555.5_Missense_Mutation_p.S278N|FBXW7_ENST00000603841.1_Missense_Mutation_p.S396N|FBXW7_ENST00000393956.3_Missense_Mutation_p.S220N	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	396					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATCAGAACCACTAACTATTCG	0.348			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								44	7					0	0	1	0	0	T	153250873	C	T	153250873	3	4	2	1	0	0	0	0	1	0	0	0	5801	565	20	3	956	3	FBXW7	4	153250873	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		153250873	37903403	15	74										
SKIV2L2	23517	broad.mit.edu	37	chr5	54619970	54619970	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tctttttaagtttggcagacCtgatgcccagagtcaaggta	10	8	2	3			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr5:54619970C>A	ENST00000230640.5	+	3	537	c.283C>A	c.(283-285)Ctg>Atg	p.L95M	SKIV2L2_ENST00000504388.1_3'UTR|SKIV2L2_ENST00000545714.1_Intron	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	95					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTTGGCAGACCTGATGCCCAG	0.348													6	18					3.59834e-05	3.79284e-05	1	1	0	A	54619970	C	A	54619970	3	1	2	1	0	0	0	0	1	0	0	0	14414	680	24	5	293	5	SKIV2L2	5	54619970	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		54619970	126295290	16	75										
ACOT12	134526	broad.mit.edu	37	chr5	80626633	80626633	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	agatgtttcatcaaacttacGatgcatgaattgctgtcaat	7	7	3	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr5:80626633G>T	ENST00000307624.3	-	14	1546	c.1518_splice	c.e14+1	p.I506_splice	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	506	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TCAAACTTACGATGCATGAAT	0.398													16	25					2.32078e-09	2.66208e-09	1	1	0	T	80626633	G	T	80626633	5	4	2	1	0	0	0	0	0	0	1	0	150	1072	37	2	157	2	ACOT12	5	80626633	Splice_Site	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	26006663	80626633	100288627	17	76										
RUNX2	860	broad.mit.edu	37	chr6	45390482	45390482	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	agcaacagcagcagcagcagCaggaggcggcggcggcggct	18	12	0	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr6:45390482C>G	ENST00000371438.1	+	2	569	c.211C>G	c.(211-213)Cag>Gag	p.Q71E	RUNX2_ENST00000465038.2_Missense_Mutation_p.Q71E|RUNX2_ENST00000352853.5_Missense_Mutation_p.Q139E|RUNX2_ENST00000371432.3_Missense_Mutation_p.Q57E|RUNX2_ENST00000371436.6_Missense_Mutation_p.Q71E|RUNX2_ENST00000576263.1_Missense_Mutation_p.Q71E|RUNX2_ENST00000541979.1_Missense_Mutation_p.Q139E|RUNX2_ENST00000359524.5_Missense_Mutation_p.Q57E	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	71	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						gcagcagcagcaggaggcggc	0.716													3	47					0	0	1	0	0	G	45390482	C	G	45390482	3	3	2	1	0	0	0	0	1	0	0	0	13799	711	25	5	233	5	RUNX2	6	45390482	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		45390482	125724585	18	77										
KIAA1244	57221	broad.mit.edu	37	chr6	138584324	138584324	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtcgtgcagagaagccacacGgtcccttaccctgacataac	9	14	0	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr6:138584324G>T	ENST00000251691.4	+	12	1870	c.1704G>T	c.(1702-1704)acG>acT	p.T568T		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	568					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GAAGCCACACGGTCCCTTACC	0.507													10	118					1.76689e-08	1.96882e-08	1	1	0	T	138584324	G	T	138584324	2	4	2	1	0	0	0	0	0	0	0	1	8258	1103	39	5		5	KIAA1244	6	138584324	Silent	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	93193842	138584324	32530743	19	78										
DDX56	54606	broad.mit.edu	37	chr7	44608737	44608737	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acagcagctcaccctgcagcGatagcggaagccctcgatct	10	15	2	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr7:44608737G>T	ENST00000258772.5	-	10	1391	c.1285C>A	c.(1285-1287)Cgc>Agc	p.R429S	DDX56_ENST00000431640.1_Missense_Mutation_p.R389S|DDX56_ENST00000485367.1_5'UTR	NM_001257189.1|NM_019082.3	NP_001244118.1|NP_061955.1	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 56	429					rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding	p.R429C(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)	16						ACCCTGCAGCGATAGCGGAAG	0.627													20	74					1.96292e-10	2.28519e-10	1	1	0	T	44608737	G	T	44608737	3	4	2	1	0	0	0	0	1	0	0	0	4397	1058	37	2	378	2	DDX56	7	44608737	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08		44608737	114529926	20	79										
MUC17	140453	broad.mit.edu	37	chr7	100684160	100684160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cttctgaaggtaccagcatgCcaacctcaactcctagtgaa	7	13	2	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr7:100684160C>T	ENST00000306151.4	+	3	9527	c.9463C>T	c.(9463-9465)Cca>Tca	p.P3155S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3155	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.478													6	758					0	0	1	0	0	T	100684160	C	T	100684160	3	4	2	1	0	0	0	0	1	0	0	0	10021	739	26	3	9473	3	MUC17	7	100684160	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	56075423	100684160	58454503	21	80										
PIK3CG	5294	broad.mit.edu	37	chr7	106508394	106508394	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gctactggaaggccacgcacCggagcccgggccagatccac	13	16	0	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr7:106508394C>T	ENST00000359195.3	+	2	698	c.388C>T	c.(388-390)Cgg>Tgg	p.R130W	PIK3CG_ENST00000440650.2_Missense_Mutation_p.R130W|PIK3CG_ENST00000496166.1_Missense_Mutation_p.R130W	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	130					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GGCCACGCACCGGAGCCCGGG	0.637													33	39					0	0	1	0	0	T	106508394	C	T	106508394	3	4	2	1	0	0	0	0	1	0	0	0	11963	643	23	1	390	1	PIK3CG	7	106508394	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	5824234	106508394	52630269	22	81										
TNPO3	23534	broad.mit.edu	37	chr7	128630096	128630096	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtatcgcacagccgtatgtaCggtctccgggaggcggacaa	14	11	1	0	rs150330408		TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr7:128630096C>T	ENST00000393245.1	-	11	1892	c.1519G>A	c.(1519-1521)Gta>Ata	p.V507I	TNPO3_ENST00000471234.1_Missense_Mutation_p.V473I|TNPO3_ENST00000265388.5_Missense_Mutation_p.V473I|TNPO3_ENST00000471166.1_Missense_Mutation_p.V507I|TNPO3_ENST00000482320.1_Missense_Mutation_p.V407I	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	473					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						GCCGTATGTACGGTCTCCGGG	0.478													88	107					0	0	1	0	0	T	128630096	C	T	128630096	3	4	2	1	0	0	0	0	1	0	0	0	16396	536	19	1	1402	1	TNPO3	7	128630096	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	22121702	128630096	30508567	23	82										
BAG4	9530	broad.mit.edu	37	chr8	38067982	38067982	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tttgtaagattcaggccataCtggaaaaattagaaaaaaaa	7	4	1	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr8:38067982C>G	ENST00000287322.4	+	5	1616	c.1345C>G	c.(1345-1347)Ctg>Gtg	p.L449V	BAG4_ENST00000432471.2_Missense_Mutation_p.L413V	NM_004874.3	NP_004865.1	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	449	BAG.				anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|urinary_tract(1)	11	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				TCAGGCCATACTGGAAAAATT	0.408													4	96					0	0	1	0	0	G	38067982	C	G	38067982	3	3	2	1	0	0	0	0	1	0	0	0	1287	564	20	5	1363	5	BAG4	8	38067982	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		38067982	108296040	24	83										
TGS1	96764	broad.mit.edu	37	chr8	56711599	56711599	+	Frame_Shift_Del	DEL	A	A	-													0	0	1	0	0	0	1	1	0	aggaacaagacatgtctgttAaaaaaggtgatgacctactg							TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr8:56711599delA	ENST00000260129.5	+	8	2146	c.1669delA	c.(1669-1671)aafs	p.K558fs		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	558					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CATGTCTGTTAAAAAAGGTGA	0.403													7	834	---	---	---	---						-	56711599	A	-	56711599	7	5	2	1	0	1	0	1	0	0	0	0	15896	363	13	0	1699	0	TGS1	8	56711599	Frame_Shift_Del	DEL	A	TCGA-N5-A4RA-01A-11D-A28R-08	18643617	56711599	89652423	25	84										
SULF1	23213	broad.mit.edu	37	chr8	70541903	70541903	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	caaccactggcagacagcccCgttctggaaccgtaagttgc	10	14	1	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr8:70541903C>G	ENST00000260128.4	+	19	2990	c.2273C>G	c.(2272-2274)cCg>cGg	p.P758R	SULF1_ENST00000458141.2_Missense_Mutation_p.P758R|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Missense_Mutation_p.P758R|SULF1_ENST00000419716.3_Missense_Mutation_p.P758R	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	758					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CAGACAGCCCCGTTCTGGAAC	0.522													66	1417					0	0	1	0	0	G	70541903	C	G	70541903	3	3	2	1	0	0	0	0	1	0	0	0	15425	652	23	5	2331	5	SULF1	8	70541903	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	13830304	70541903	75822119	26	85										
MTSS1	9788	broad.mit.edu	37	chr8	125711778	125711778	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tctgcttaccacgtgtgttgGtggccatgtcagccactttc	10	12	2	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr8:125711778G>T	ENST00000518547.1	-	3	670	c.197C>A	c.(196-198)aCc>aAc	p.T66N	MTSS1_ENST00000325064.5_Missense_Mutation_p.T66N|MTSS1_ENST00000354184.4_5'UTR|MTSS1_ENST00000378017.3_Missense_Mutation_p.T66N	NM_014751.4	NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	66	IMD.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ACGTGTGTTGGTGGCCATGTC	0.493													26	24					2.41591e-17	2.89909e-17	1	1	0	T	125711778	G	T	125711778	3	4	2	1	0	0	0	0	1	0	0	0	10009	1261	44	5	2118	5	MTSS1	8	125711778	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	55169875	125711778	20652244	27	86										
ZMIZ1	57178	broad.mit.edu	37	chr10	81050918	81050918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gcccaactaccccggcagcgGgggctttggggccaggtgag	17	13	0	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr10:81050918G>A	ENST00000334512.5	+	10	1315	c.743G>A	c.(742-744)gGg>gAg	p.G248E	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	248					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CCCGGCAGCGGGGGCTTTGGG	0.652													7	38					0	0	1	0	0	A	81050918	G	A	81050918	3	1	2	1	0	0	0	0	1	0	0	0	17753	1232	43	3	765	3	ZMIZ1	10	81050918	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08		81050918	54483829	28	87										
OR51G1	79324	broad.mit.edu	37	chr11	4944753	4944753	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ggacatgaagaggtgtacaaCgcggggcagatgttcaccaa	14	8	1	3			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr11:4944753C>T	ENST00000321961.2	-	1	884	c.817G>A	c.(817-819)Gtt>Att	p.V273I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGTGTACAACGCGGGGCAGA	0.493													5	106					0	0	1	0	0	T	4944753	C	T	4944753	3	4	2	1	0	0	0	0	1	0	0	0	11145	536	19	1	150	1	OR51G1	11	4944753	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		4944753	130061763	29	88										
SCUBE2	57758	broad.mit.edu	37	chr11	9082062	9082062	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cacagcctccattgttgacaGcacacgtttctggcaaggag	10	12	1	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr11:9082062G>A	ENST00000457346.2	-	8	934	c.860C>T	c.(859-861)gCt>gTt	p.A287V	SCUBE2_ENST00000450649.2_Missense_Mutation_p.A287V|RP11-467K18.2_ENST00000521394.2_RNA|SCUBE2_ENST00000520467.1_Missense_Mutation_p.A287V|SCUBE2_ENST00000309263.3_Missense_Mutation_p.A287V			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	287	EGF-like 6 (Potential).					extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ATTGTTGACAGCACACGTTTC	0.498													4	134					0	0	1	0	0	A	9082062	G	A	9082062	3	1	2	1	0	0	0	0	1	0	0	0	13998	971	34	3	2290	3	SCUBE2	11	9082062	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	4137309	9082062	125924454	30	89										
MAP3K11	4296	broad.mit.edu	37	chr11	65380919	65380919	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tcgcaggggggcgggccgccAccccgagacacatagttgga	16	13	0	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr11:65380919A>C	ENST00000309100.3	-	1	794	c.309T>G	c.(307-309)ggT>ggG	p.G103G		NM_002419.3	NP_002410.1	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase 11	103	Gly-rich.|SH3.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(14)|skin(1)	24						GCGGGCCGCCACCCCGAGACA	0.687													9	113					0	0	1	0	0	C	65380919	A	C	65380919	2	2	2	1	0	0	0	0	0	0	0	1	9294	146	6	4		4	MAP3K11	11	65380919	Silent	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08	56298857	65380919	69625597	31	90										
NTF3	4908	broad.mit.edu	37	chr12	5603608	5603609	+	Frame_Shift_Ins	INS	-	-	C													0	0	1	0	0	0	1	1	0	gagagccggagcggggagggINScccgccaagtcagcattcca							TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr12:5603608_5603609insC	ENST00000423158.3	+	2	479_480	c.267_268insC	c.(265-270)ggccgcfs	p.R90fs	NTF3_ENST00000331010.6_Frame_Shift_Ins_p.R77fs|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	77					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						AGCGGGGAGGGCCCGCCAAGTC	0.579													8	125	---	---	---	---						C	5603609	-	C	5603608	7	5	2	1	0	1	1	0	0	0	0	0	10743	1190	42	0	273	0	NTF3	12	5603608	Frame_Shift_Ins	INS	-	TCGA-N5-A4RA-01A-11D-A28R-08		5603608	128248287	32	91										
PRH1	5554	broad.mit.edu	37	chr12	11036812	11036812	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccactgacagcagaatcagaAgcatcttgcaggaggctctg	11	11	3	3			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr12:11036812A>G	ENST00000428168.2	-	1	42	c.5T>C	c.(4-6)cTt>cCt	p.L2P	PRR4_ENST00000536668.1_5'UTR	NM_006250.3	NP_006241.2	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	2						extracellular space	protein binding			endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	5				BRCA - Breast invasive adenocarcinoma(232;0.245)		CAGAATCAGAAGCATCTTGCA	0.488													19	61					0	0	1	0	0	G	11036812	A	G	11036812	3	3	2	1	0	0	0	0	1	0	0	0	12533	72	3	4	511	4	PRH1	12	11036812	Missense_Mutation	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08	5433204	11036812	122815083	33	92										
KRT6C	286887	broad.mit.edu	37	chr12	52865910	52865910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gctccgagtccaggcggcccCgttccccgacgatgctgtcc	12	18	0	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr12:52865910C>T	ENST00000252250.6	-	2	742	c.695G>A	c.(694-696)cGg>cAg	p.R232Q		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	232	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		CAGGCGGCCCCGTTCCCCGAC	0.572													100	24					0	0	1	0	0	T	52865910	C	T	52865910	3	4	2	1	0	0	0	0	1	0	0	0	8524	652	23	1	1031	1	KRT6C	12	52865910	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	41829098	52865910	80985985	34	93										
TPTE2	93492	broad.mit.edu	37	chr13	20041425	20041425	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aaatgacatcaaccagcagaGgaatcacaataatggcagta	8	8	2	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr13:20041425G>A	ENST00000400230.2	-	7	496	c.452C>T	c.(451-453)cCt>cTt	p.P151L	TPTE2_ENST00000382978.1_Intron|TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000382975.4_Intron|TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000400103.2_Intron|TPTE2_ENST00000382977.4_Missense_Mutation_p.P151L			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	151						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		AACCAGCAGAGGAATCACAAT	0.289													3	78					0	0	1	0	0	A	20041425	G	A	20041425	3	1	2	1	0	0	0	0	1	0	0	0	16491	1000	35	3	1172	3	TPTE2	13	20041425	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08		20041425	95128453	35	94										
TRPC4	7223	broad.mit.edu	37	chr13	38237782	38237782	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gatcagacgcagagaactgaAgatgtttgcaatagcaaata	10	6	1	4			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr13:38237782A>C	ENST00000379705.3	-	6	2316	c.1459T>G	c.(1459-1461)Ttc>Gtc	p.F487V	TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000355779.2_Missense_Mutation_p.F487V|TRPC4_ENST00000358477.2_Missense_Mutation_p.F487V|TRPC4_ENST00000379679.1_Missense_Mutation_p.F314V|TRPC4_ENST00000338947.5_Missense_Mutation_p.F314V|TRPC4_ENST00000379681.3_Missense_Mutation_p.F487V|TRPC4_ENST00000379673.2_Missense_Mutation_p.F487V|TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000447043.1_Missense_Mutation_p.F487V			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	487					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AGAGAACTGAAGATGTTTGCA	0.448													22	53					0	0	1	0	0	C	38237782	A	C	38237782	3	2	2	1	0	0	0	0	1	0	0	0	16640	72	3	4	1513	4	TRPC4	13	38237782	Missense_Mutation	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08	18196357	38237782	76932096	36	95										
ARID4A	5926	broad.mit.edu	37	chr14	58795010	58795010	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gaaaaaggatcagtgtttagTtcgatcatttattgattcta	8	4	3	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr14:58795010T>G	ENST00000355431.3	+	9	1011	c.638T>G	c.(637-639)gTt>gGt	p.V213G	ARID4A_ENST00000395168.3_Missense_Mutation_p.V213G|ARID4A_ENST00000431317.2_Missense_Mutation_p.V213G|ARID4A_ENST00000348476.3_Missense_Mutation_p.V213G	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	213					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CAGTGTTTAGTTCGATCATTT	0.333													15	20					0	0	1	0	0	G	58795010	T	G	58795010	3	3	2	1	0	0	0	0	1	0	0	0	916	1725	60	4	668	4	ARID4A	14	58795010	Missense_Mutation	SNP	T	TCGA-N5-A4RA-01A-11D-A28R-08		58795010	48554530	37	96										
DAAM1	23002	broad.mit.edu	37	chr14	59793305	59793305	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	agatagttatccagaatgacAaaggacaggaccctgactcc	9	10	0	4			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr14:59793305A>T	ENST00000395125.1	+	10	1275	c.1252A>T	c.(1252-1254)Aaa>Taa	p.K418*	DAAM1_ENST00000360909.3_Nonsense_Mutation_p.K418*|DAAM1_ENST00000351081.1_Nonsense_Mutation_p.K418*	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	418	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CCAGAATGACAAAGGACAGGA	0.378													46	45					0	0	1	0	0	T	59793305	A	T	59793305	4	4	2	1	0	0	0	0	0	1	0	0	4239	131	5	4	1290	4	DAAM1	14	59793305	Nonsense_Mutation	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08	998295	59793305	47556235	38	97										
SPTB	6710	broad.mit.edu	37	chr14	65253730	65253730	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gatgatacctgccaggtcccGccccaggtcttttgtggact	11	13	1	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr14:65253730G>A	ENST00000389722.3	-	15	3006	c.2953C>T	c.(2953-2955)Cgg>Tgg	p.R985W	SPTB_ENST00000556626.1_Missense_Mutation_p.R985W|SPTB_ENST00000542895.1_Missense_Mutation_p.R985W|SPTB_ENST00000389720.3_Missense_Mutation_p.R985W|SPTB_ENST00000389721.5_Missense_Mutation_p.R985W	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	985					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCCAGGTCCCGCCCCAGGTCT	0.602													28	42					0	0	1	0	0	A	65253730	G	A	65253730	3	1	2	1	0	0	0	0	1	0	0	0	15173	1086	38	1	4186	1	SPTB	14	65253730	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	5460425	65253730	42095810	39	98										
MAPKBP1	23005	broad.mit.edu	37	chr15	42109861	42109861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acaccacgtggtgcggaagaCgaccctctatgacatggatg	12	11	1	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr15:42109861C>T	ENST00000457542.2	+	16	2118	c.1832C>T	c.(1831-1833)aCg>aTg	p.T611M	MAPKBP1_ENST00000456763.2_Missense_Mutation_p.T617M|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.T494M|MAPKBP1_ENST00000260357.7_Missense_Mutation_p.T450M|MAPKBP1_ENST00000514566.1_Missense_Mutation_p.T611M	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	617										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GTGCGGAAGACGACCCTCTAT	0.612													27	20					0	0	1	0	0	T	42109861	C	T	42109861	3	4	2	1	0	0	0	0	1	0	0	0	9341	536	19	1	1912	1	MAPKBP1	15	42109861	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		42109861	60421531	40	99										
SPATA8	145946	broad.mit.edu	37	chr15	97326808	97326808	+	Translation_Start_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gctccatctccgctaagcccAgggatccacttgtgtgtctt	9	14	2	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr15:97326808A>T	ENST00000328504.3	+	0	190				SPATA8_ENST00000558553.1_De_novo_Start_InFrame	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8											large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			CGCTAAGCCCAGGGATCCACT	0.567													3	50					0	0	1	0	0	T	97326808	A	T	97326808	1	4	2	1	0	0	0	0	0	0	0	0	15070	203	7	4		4	SPATA8	15	97326808	Translation_Start_Site	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08	55216947	97326808	5204584	41	100										
NLRC3	197358	broad.mit.edu	37	chr16	3613764	3613764	+	RNA	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccccaccatcttgcggccacCatgggccacctgctcgatgc	9	19	1	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr16:3613764C>A	ENST00000301749.7	-	0	1579				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000324659.8_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TTGCGGCCACCATGGGCCACC	0.587													14	21					1.49906e-05	1.62398e-05	1	1	0	A	3613764	C	A	3613764	1	1	2	0	1	0	0	0	0	0	0	0	10514	594	21	5		5	NLRC3	16	3613764	RNA	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		3613764	86740989	42	101										
TP53	7157	broad.mit.edu	37	chr17	7579718	7579718	+	Frame_Shift_Del	DEL	A	A	-													0	0	1	0	0	0	1	1	0	accagaacgttgttttcaggAagtctgaaagacaagagcag							TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr17:7579718delA	ENST00000420246.2	-	3	210	c.78delT	c.(76-78)ctfs	p.L26fs	TP53_ENST00000359597.4_Frame_Shift_Del_p.L26fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.L26fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.L26fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.L26fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.L26fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	26	Interaction with HRMT1L2.|Transcription activation (acidic).				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.L26fs*18(1)|p.P13fs*18(1)|p.L26fs*11(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTTTTCAGGAAGTCTGAAAG	0.622		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			56	23	---	---	---	---						-	7579718	A	-	7579718	7	5	2	1	0	1	0	1	0	0	0	0	16441	233	9	0	1228	0	TP53	17	7579718	Frame_Shift_Del	DEL	A	TCGA-N5-A4RA-01A-11D-A28R-08		7579718	73615492	43	102										
WDR7	23335	broad.mit.edu	37	chr18	54385303	54385303	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	catctcgtcacctttttcctAttcaagtaatcaaatggagg	6	10	4	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr18:54385303A>G	ENST00000254442.3	+	13	1898	c.1687A>G	c.(1687-1689)Att>Gtt	p.I563V	WDR7_ENST00000357574.3_Missense_Mutation_p.I563V|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	563										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		CCTTTTTCCTATTCAAGTAAT	0.443													36	99					0	0	1	0	0	G	54385303	A	G	54385303	3	3	2	1	0	0	0	0	1	0	0	0	17379	449	16	4	1733	4	WDR7	18	54385303	Missense_Mutation	SNP	A	TCGA-N5-A4RA-01A-11D-A28R-08		54385303	23691945	44	103										
ZNF254	9534	broad.mit.edu	37	chr19	24309473	24309473	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aacctttaattggtcctcaaCccttactaatcataggaaaa	4	10	2	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr19:24309473C>T	ENST00000357002.4	+	4	786	c.671C>T	c.(670-672)aCc>aTc	p.T224I	ZNF254_ENST00000342944.6_Missense_Mutation_p.T139I	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	224					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T224I(1)					all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TGGTCCTCAACCCTTACTAAT	0.328													22	51					0	0	1	0	0	T	24309473	C	T	24309473	3	4	2	1	0	0	0	0	1	0	0	0	17855	507	18	3	685	3	ZNF254	19	24309473	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		24309473	34819510	45	104										
NCOA3	8202	broad.mit.edu	37	chr20	46279833	46279833	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	atgcagcagcagcagcagcaGcaacagcagcagcagcagca	12	13	0	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr20:46279833G>A	ENST00000372004.3	+	20	3963	c.3747G>A	c.(3745-3747)caG>caA	p.Q1249Q	NCOA3_ENST00000371997.3_Silent_p.Q1244Q|NCOA3_ENST00000371998.3_Silent_p.Q1253Q|NCOA3_ENST00000341724.6_Silent_p.Q1179Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1253	Acetyltransferase.|Poly-Gln.		Missing.		androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcaacagcagc	0.547													4	86					0	0	1	0	0	A	46279833	G	A	46279833	2	1	2	1	0	0	0	0	0	0	0	1	10276	962	34	3		3	NCOA3	20	46279833	Silent	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08		46279833	16745687	46	105										
ZNF831	128611	broad.mit.edu	37	chr20	57766698	57766698	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgtcctcagagtccgagggCgccgggggcggcctcctgga	17	14	1	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr20:57766698C>A	ENST00000371030.2	+	1	624	c.624C>A	c.(622-624)ggC>ggA	p.G208G		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	208						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGTCCGAGGGCGCCGGGGGCG	0.677													42	131					7.05377e-20	8.59678e-20	1	1	0	A	57766698	C	A	57766698	2	1	2	1	0	0	0	0	0	0	0	1	18231	755	27	5		5	ZNF831	20	57766698	Silent	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	11486865	57766698	5258822	47	106			1	1		2	2	27	N	G_C	4.535257e-05
ZNF831	128611	broad.mit.edu	37	chr20	57766724	57766724	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gggcggcctcctggaggaagGggacaaggccggagagcccc	19	12	0	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr20:57766724G>T	ENST00000371030.2	+	1	650	c.650G>T	c.(649-651)gGg>gTg	p.G217V		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	217						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CTGGAGGAAGGGGACAAGGCC	0.687													32	124					4.00102e-26	4.95364e-26	1	1	0	T	57766724	G	T	57766724	3	4	2	1	0	0	0	0	1	0	0	0	18231	1232	43	5	652	5	ZNF831	20	57766724	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08	26	57766724	5258796	48	107			1	1		2	2	27	N	G_C	4.535257e-05
TRPM2	7226	broad.mit.edu	37	chr21	45844759	45844759	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cccagacagcccaagccctgCactggatcgtgaggacgctg	12	15	0	2			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr21:45844759C>T	ENST00000397928.1	+	24	4019	c.3574C>T	c.(3574-3576)Cac>Tac	p.H1192Y	TRPM2_ENST00000397932.2_Missense_Mutation_p.H1242Y|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.H1192Y|TRPM2_ENST00000300481.9_Missense_Mutation_p.H1172Y	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1192						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCAAGCCCTGCACTGGATCGT	0.682													12	8					0	0	1	0	0	T	45844759	C	T	45844759	3	4	2	1	0	0	0	0	1	0	0	0	16646	710	25	3	3668	3	TRPM2	21	45844759	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		45844759	2285136	49	108										
SEPT5	5413	broad.mit.edu	37	chr22	19709220	19709220	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tggtggaggccaaggggcagCgggtccggggccgactgtac	20	10	0	0			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr22:19709220C>T	ENST00000438754.2	+	8	1082	c.802C>T	c.(802-804)Cgg>Tgg	p.R268W	SEPT5_ENST00000383045.3_Missense_Mutation_p.R268W|SEPT5_ENST00000455784.2_Missense_Mutation_p.R259W|SEPT5_ENST00000406395.1_Missense_Mutation_p.R259W	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	259					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					CAAGGGGCAGCGGGTCCGGGG	0.672													31	120					0	0	1	0	0	T	19709220	C	T	19709220	3	4	2	1	0	0	0	0	1	0	0	0	14120	759	27	1	809	1	SEPT5	22	19709220	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08		19709220	31595346	50	109										
PLXNB2	23654	broad.mit.edu	37	chr22	50716562	50716562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccaccttgactgagagcagcCgcgtcaggtagatctcggtg	13	12	2	3			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chr22:50716562C>T	ENST00000449103.1	-	31	5011	c.4871G>A	c.(4870-4872)cGg>cAg	p.R1624Q	PLXNB2_ENST00000359337.4_Missense_Mutation_p.R1624Q			O15031	PLXB2_HUMAN	plexin B2	1624					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGAGAGCAGCCGCGTCAGGTA	0.687													28	9					0	0	1	0	0	T	50716562	C	T	50716562	3	4	2	1	0	0	0	0	1	0	0	0	12171	652	23	1	673	1	PLXNB2	22	50716562	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	31007342	50716562	588004	51	110										
CXorf22	170063	broad.mit.edu	37	chrX	35993823	35993823	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cagtgaacaatgtacccagtGgacacatcctagtggtggca	11	10	0	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chrX:35993823G>A	ENST00000297866.5	+	15	2572	c.2506G>A	c.(2506-2508)Gga>Aga	p.G836R		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	836										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TGTACCCAGTGGACACATCCT	0.388													47	68					0	0	1	0	0	A	35993823	G	A	35993823	3	1	2	1	0	0	0	0	1	0	0	0	4125	1349	47	3	2564	3	CXorf22	23	35993823	Missense_Mutation	SNP	G	TCGA-N5-A4RA-01A-11D-A28R-08		35993823	119276737	52	111										
ATG4A	115201	broad.mit.edu	37	chrX	107374496	107374496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cattttgccaacaggtggaaCgggcccttcatcagatgctg	11	11	2	1			TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chrX:107374496C>T	ENST00000372232.3	+	4	359	c.200C>T	c.(199-201)aCg>aTg	p.T67M	ATG4A_ENST00000372254.3_Missense_Mutation_p.T43M|ATG4A_ENST00000545696.1_5'UTR|ATG4A_ENST00000345734.3_Missense_Mutation_p.T67M	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	67					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						ACAGGTGGAACGGGCCCTTCA	0.473													38	87					0	0	1	0	0	T	107374496	C	T	107374496	3	4	2	1	0	0	0	0	1	0	0	0	1095	536	19	1	214	1	ATG4A	23	107374496	Missense_Mutation	SNP	C	TCGA-N5-A4RA-01A-11D-A28R-08	71380673	107374496	47896064	53	112										
MAGEA6	4105	broad.mit.edu	37	chrX	151870055	151870055	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccaagaagctgctcacccaaTatttcgtgcaggaaaactac	7	12	1	1	rs140963484	byFrequency	TCGA-N5-A4RA-01A-11D-A28R-08	TCGA-N5-A4RA-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3dc3c63-8571-457e-b20e-775f7fd21b7b	81db3ca2-9fc2-41e6-8d59-f99d874a163d	g.chrX:151870055T>C	ENST00000329342.5	+	3	970	c.745T>C	c.(745-747)Tat>Cat	p.Y249H		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	249	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCACCCAATATTTCGTGCA	0.547													83	147					0	0	1	0	0	C	151870055	T	C	151870055	3	2	2	1	0	0	0	0	1	0	0	0	9217	1406	49	4	747	4	MAGEA6	23	151870055	Missense_Mutation	SNP	T	TCGA-N5-A4RA-01A-11D-A28R-08	44495559	151870055	3400505	54	113										
INADL	10207	broad.mit.edu	37	chr1	62237128	62237128	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	aaagattaaaggaaaatgatCaaatattggccattaatcac	6	5	2	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:62237128C>T	ENST00000371158.2	+	6	664	c.550C>T	c.(550-552)Caa>Taa	p.Q184*	INADL_ENST00000316485.6_Nonsense_Mutation_p.Q184*	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	184	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GGAAAATGATCAAATATTGGC	0.308													8	8					0	0	1	0	0	T	62237128	C	T	62237128	4	4	3	1	0	0	0	0	0	1	0	0	7774	827	29	3	568	3	INADL	1	62237128	Nonsense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		62237128	187013493	1	114										
SEC22B	9554	broad.mit.edu	37	chr1	145109631	145109631	+	RNA	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gcactcagaatttgatgaacAgcatggaaagaaggtgccca	11	8	1	4			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:145109631A>C	ENST00000453618.1	+	0	620							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TTTGATGAACAGCATGGAAAG	0.438													47	431					0	0	1	0	0	C	145109631	A	C	145109631	1	2	3	0	1	0	0	0	0	0	0	0	14042	188	7	4		4	SEC22B	1	145109631	RNA	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	82872503	145109631	104140990	2	115										
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858535	149858535	+	Missense_Mutation	SNP	G	G	A													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gatttcagtcatgtctggtcGtggcaaacaaggaggcaagg							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:149858535G>A	ENST00000331380.2	+	1	11	c.11G>A	c.(10-12)cGt>cAt	p.R4H		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	4					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			ATGTCTGGTCGTGGCAAACAA	0.542													39	80					0	0	1	0	0	A	149858535	G	A	149858535	3	1	3	1	0	0	0	0	1	0	0	0	7218	1145	40	1	13	1	HIST2H2AC	1	149858535	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	4748904	149858535	99392086	3	116	1	3								
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858536	149858536	+	Silent	SNP	T	T	G													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	atttcagtcatgtctggtcgTggcaaacaaggaggcaaggc							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:149858536T>G	ENST00000331380.2	+	1	12	c.12T>G	c.(10-12)cgT>cgG	p.R4R		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	4					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TGTCTGGTCGTGGCAAACAAG	0.547													39	80					0	0	1	0	0	G	149858536	T	G	149858536	2	3	3	1	0	0	0	0	0	0	0	1	7218	1683	59	4		4	HIST2H2AC	1	149858536	Silent	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	1	149858536	99392085	4	117	1	3								
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858537	149858537	+	Missense_Mutation	SNP	G	G	T													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tttcagtcatgtctggtcgtGgcaaacaaggaggcaaggcc							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:149858537G>T	ENST00000331380.2	+	1	13	c.13G>T	c.(13-15)Ggc>Tgc	p.G5C		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	5					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GTCTGGTCGTGGCAAACAAGG	0.547													41	78					3.54561e-26	3.75417e-26	1	1	0	T	149858537	G	T	149858537	3	4	3	1	0	0	0	0	1	0	0	0	7218	1348	47	5	15	5	HIST2H2AC	1	149858537	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	1	149858537	99392084	5	118	1	3								
RPRD2	23248	broad.mit.edu	37	chr1	150443187	150443187	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tgcccaaccttttattcccaAaagcttcaactattctccta	2	14	2	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:150443187A>G	ENST00000401000.4	+	10	1750	c.1685A>G	c.(1684-1686)aAa>aGa	p.K562R	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.K588R|RPRD2_ENST00000539519.1_Missense_Mutation_p.K562R			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	588	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TTTATTCCCAAAAGCTTCAAC	0.502													14	28					0	0	1	0	0	G	150443187	A	G	150443187	3	3	3	1	0	0	0	0	1	0	0	0	13668	14	1	4	1805	4	RPRD2	1	150443187	Missense_Mutation	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	584650	150443187	98807434	6	119										
HMCN1	83872	broad.mit.edu	37	chr1	186121933	186121933	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gggcttggattccgatggttCtttgctgctagatatcgttg	13	7	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr1:186121933C>T	ENST00000271588.4	+	96	15177	c.14948C>T	c.(14947-14949)tCt>tTt	p.S4983F	HMCN1_ENST00000367492.2_Missense_Mutation_p.S4983F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4983	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCCGATGGTTCTTTGCTGCTA	0.428													16	72					0	0	1	0	0	T	186121933	C	T	186121933	3	4	3	1	0	0	0	0	1	0	0	0	7260	913	32	3	15330	3	HMCN1	1	186121933	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	35678746	186121933	63128688	7	120										
MYT1L	23040	broad.mit.edu	37	chr2	1906908	1906908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gcaccttgggagctatggctCgcttgccataagtatggttg	13	9	0	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr2:1906908C>T	ENST00000399161.2	-	14	2723	c.1976G>A	c.(1975-1977)cGa>cAa	p.R659Q	MYT1L_ENST00000428368.2_Missense_Mutation_p.R657Q	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	659					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		AGCTATGGCTCGCTTGCCATA	0.488													4	49					0	0	1	0	0	T	1906908	C	T	1906908	3	4	3	1	0	0	0	0	1	0	0	0	10154	884	31	1	1632	1	MYT1L	2	1906908	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		1906908	241292465	8	121										
SPTBN1	0	broad.mit.edu	37	chr2	54853210	54853210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tcgaggccgagaattaccacGacatcaagcgcatcacagcg	10	13	2	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr2:54853210G>A	ENST00000333896.5	+	11	1829	c.1444G>A	c.(1444-1446)Gac>Aac	p.D482N	SPTBN1_ENST00000356805.4_Missense_Mutation_p.D495N	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	495					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GAATTACCACGACATCAAGCG	0.577													75	101					0	0	1	0	0	A	54853210	G	A	54853210	3	1	3	1	0	0	0	0	1	0	0	0	15174	1058	37	1	1638	1	SPTBN1	2	54853210	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	52946302	54853210	188346163	9	122										
ASPRV1	151516	broad.mit.edu	37	chr2	70187809	70187809	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tcagtgggatagctcctgccGcccttcttctgaggaggggt	14	11	3	1	rs140244507		TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr2:70187809G>A	ENST00000320256.4	-	1	1588	c.1012C>T	c.(1012-1014)Cgg>Tgg	p.R338W		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	338					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						AGCTCCTGCCGCCCTTCTTCT	0.557													34	49					0	0	1	0	0	A	70187809	G	A	70187809	3	1	3	1	0	0	0	0	1	0	0	0	1057	1086	38	1	23	1	ASPRV1	2	70187809	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	15334599	70187809	173011564	10	123										
C1QL2	165257	broad.mit.edu	37	chr2	119914536	119914536	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gtagttctggtcggcgtcctGtgcaatggcgctggcccgga	16	11	1	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr2:119914536G>T	ENST00000272520.3	-	2	1325	c.706C>A	c.(706-708)Cag>Aag	p.Q236K		NM_182528.3	NP_872334.2	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	236	C1q.					collagen				NS(1)|endometrium(1)|large_intestine(3)|pancreas(1)|prostate(1)	7						TCGGCGTCCTGTGCAATGGCG	0.642										HNSCC(49;0.14)			70	81					1.50372e-20	1.57366e-20	1	1	0	T	119914536	G	T	119914536	3	4	3	1	0	0	0	0	1	0	0	0	1972	1386	48	5	161	5	C1QL2	2	119914536	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	49726727	119914536	123284837	11	124										
PHF7	51533	broad.mit.edu	37	chr3	52454935	52454935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	acagatcattttgtgacaaaCatcgcccaacacagaacatc	5	12	1	3			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:52454935C>T	ENST00000327906.3	+	7	1090	c.430C>T	c.(430-432)Cat>Tat	p.H144Y	PHF7_ENST00000478707.1_Missense_Mutation_p.H144Y|PHF7_ENST00000347025.2_Missense_Mutation_p.H144Y	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	144						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		TTGTGACAAACATCGCCCAAC	0.488													46	10					0	0	1	0	0	T	52454935	C	T	52454935	3	4	3	1	0	0	0	0	1	0	0	0	11886	478	17	3	452	3	PHF7	3	52454935	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		52454935	145567495	12	125										
PTPRG	5793	broad.mit.edu	37	chr3	62259445	62259445	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agactgaagtatcttcaaatCagctgcacagctatgttaac	7	9	3	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:62259445C>T	ENST00000474889.1	+	23	3768	c.3391C>T	c.(3391-3393)Cag>Tag	p.Q1131*	PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG_ENST00000295874.10_Nonsense_Mutation_p.Q1102*|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1131					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATCTTCAAATCAGCTGCACAG	0.413													27	9					0	0	1	0	0	T	62259445	C	T	62259445	4	4	3	1	0	0	0	0	0	1	0	0	12853	827	29	3	3481	3	PTPRG	3	62259445	Nonsense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	9804510	62259445	135762985	13	126										
EPHB1	2047	broad.mit.edu	37	chr3	134670683	134670683	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ttcttcaaaaagtgtcccagCattgtgcaaaattttgcagt	7	8	2	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:134670683C>A	ENST00000398015.3	+	3	964	c.594C>A	c.(592-594)agC>agA	p.S198R	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	198	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						AGTGTCCCAGCATTGTGCAAA	0.483													71	77					4.83677e-39	5.18226e-39	1	1	0	A	134670683	C	A	134670683	3	1	3	1	0	0	0	0	1	0	0	0	5202	709	25	5	604	5	EPHB1	3	134670683	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	72411238	134670683	63351747	14	127										
TRPC1	7220	broad.mit.edu	37	chr3	142523431	142523431	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tcagtaagtggatttgctctCatacatcaaaaggcaaggtc	9	8	3	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:142523431C>T	ENST00000273482.6	+	11	2402	c.2011C>T	c.(2011-2013)Cat>Tat	p.H671Y	TRPC1_ENST00000476941.1_Missense_Mutation_p.H705Y	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	705					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						GATTTGCTCTCATACATCAAA	0.363													11	60					0	0	1	0	0	T	142523431	C	T	142523431	3	4	3	1	0	0	0	0	1	0	0	0	16638	826	29	3	2053	3	TRPC1	3	142523431	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	7852748	142523431	55498999	15	128										
NLGN1	22871	broad.mit.edu	37	chr3	173998971	173998971	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	cacccaacaccattacaatgAttcccaacactataccaggg	4	15	0	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:173998971A>T	ENST00000457714.1	+	7	2779	c.2350A>T	c.(2350-2352)Att>Ttt	p.I784F	NLGN1_ENST00000401917.3_Missense_Mutation_p.I824F|NLGN1_ENST00000361589.4_Missense_Mutation_p.I784F|NLGN1_ENST00000545397.1_Missense_Mutation_p.I784F	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	801					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CATTACAATGATTCCCAACAC	0.493													10	77					0	0	1	0	0	T	173998971	A	T	173998971	3	4	3	1	0	0	0	0	1	0	0	0	10507	333	12	4	2368	4	NLGN1	3	173998971	Missense_Mutation	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	31475540	173998971	24023459	16	129										
LSG1	55341	broad.mit.edu	37	chr3	194386954	194386954	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gacaagctgacgtctccattCtagaaagttatctttctctg	7	10	4	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:194386954C>G	ENST00000265245.5	-	4	726	c.412G>C	c.(412-414)Gaa>Caa	p.E138Q		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	138					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CGTCTCCATTCTAGAAAGTTA	0.373													13	36					0	0	1	0	0	G	194386954	C	G	194386954	3	3	3	1	0	0	0	0	1	0	0	0	9093	922	32	2	1608	2	LSG1	3	194386954	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	20387983	194386954	3635476	17	130										
MUC4	4585	broad.mit.edu	37	chr3	195511937	195511937	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	aggaagagaggtggcgtgacCtgtggatgctgaggaagtgt	19	4	0	3			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr3:195511937C>T	ENST00000463781.3	-	2	6973	c.6514G>A	c.(6514-6516)Ggt>Agt	p.G2172S	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.G2172S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	951					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGCGTGACCTGTGGATGCT	0.577													5	7					0	0	1	0	0	T	195511937	C	T	195511937	3	4	3	1	0	0	0	0	1	0	0	0	10025	681	24	3		3	MUC4	3	195511937	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	1124983	195511937	2510493	18	131										
LDB2	9079	broad.mit.edu	37	chr4	16900019	16900019	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ttgttcatctcatagattcgGtactctggctgtaccatgta	8	9	3	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr4:16900019G>A	ENST00000502640.1	-	1	238	c.90C>T	c.(88-90)taC>taT	p.Y30Y	LDB2_ENST00000304523.5_Silent_p.Y30Y|LDB2_ENST00000515064.1_Silent_p.Y30Y|LDB2_ENST00000441778.2_Silent_p.Y30Y			O43679	LDB2_HUMAN	LIM domain binding 2	30							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						CATAGATTCGGTACTCTGGCT	0.453													5	35					0	0	1	0	0	A	16900019	G	A	16900019	2	1	3	1	0	0	0	0	0	0	0	1	8734	1256	44	3		3	LDB2	4	16900019	Silent	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		16900019	174254257	19	132										
FBXW7	0	broad.mit.edu	37	chr4	153249384	153249384	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tttcatgaagatgcatacaaCgcacagtggaagtatgccca	9	9	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr4:153249384C>T	ENST00000281708.4	-	9	2623	c.1394G>A	c.(1393-1395)cGt>cAt	p.R465H	FBXW7_ENST00000603841.1_Missense_Mutation_p.R465H|FBXW7_ENST00000296555.5_Missense_Mutation_p.R347H|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289H|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385H|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465H	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465H(69)|p.R385H(16)|p.R226H(16)|p.R465L(4)|p.R347H(4)|p.R465Y(2)|p.?(1)|p.R385L(1)|p.R226L(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATGCATACAACGCACAGTGGA	0.408			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								16	48					0	0	1	0	0	T	153249384	C	T	153249384	3	4	3	1	0	0	0	0	1	0	0	0	5801	536	19	1	745	1	FBXW7	4	153249384	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	136349365	153249384	37904892	20	133										
TRIM2	23321	broad.mit.edu	37	chr4	154237041	154237042	+	In_Frame_Ins	INS	-	-	GGCAGCTGC													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	catacggggacgctctccggINSggcagctgcagcggcccaca							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr4:154237041_154237042insGGCAGCTGC	ENST00000338700.5	+	8	1737_1738	c.1672_1673insGGCAGCTGC	c.(1672-1674)gca>GGCAGCTGCgca	p.557_558insGSC	TRIM2_ENST00000437508.2_In_Frame_Ins_p.530_531insGSC	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	530						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		ACGCTCTCCGGGGCAGCTGCAG	0.47													11	49	---	---	---	---						GGCAGCTGC	154237042	-	GGCAGCTGC	154237041	7	5	3	1	0	1	1	0	0	0	0	0	16554	1232	43	0	1702	0	TRIM2	4	154237041	In_Frame_Ins	INS	-	TCGA-N5-A4RD-01A-11D-A28R-08	987657	154237041	36917235	21	134										
SNX25	83891	broad.mit.edu	37	chr4	186263243	186263243	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	cccagaaggctcagcgagttTcagaatttacaccggaaact	9	11	2	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr4:186263243T>C	ENST00000504273.1	+	12	1962	c.1668T>C	c.(1666-1668)ttT>ttC	p.F556F	SNX25_ENST00000264694.8_Silent_p.F556F|SNX25_ENST00000512853.1_3'UTR			Q9H3E2	SNX25_HUMAN	sorting nexin 25	556	PX.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TCAGCGAGTTTCAGAATTTAC	0.413													5	74					0	0	1	0	0	C	186263243	T	C	186263243	2	2	3	1	0	0	0	0	0	0	0	1	14949	1780	62	4		4	SNX25	4	186263243	Silent	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	32026202	186263243	4891033	22	135										
PIK3R1	5295	broad.mit.edu	37	chr5	67589138	67589138	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	attgtttttacaggaaagggGgaaataacaaattaatcaaa	8	3	1	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr5:67589138G>A	ENST00000521381.1	+	10	1742	c.1126G>A	c.(1126-1128)Gga>Aga	p.G376R	PIK3R1_ENST00000523872.1_Missense_Mutation_p.G13R|PIK3R1_ENST00000320694.8_Missense_Mutation_p.G76R|PIK3R1_ENST00000274335.5_Missense_Mutation_p.G376R|PIK3R1_ENST00000336483.5_Missense_Mutation_p.G106R|PIK3R1_ENST00000521657.1_Missense_Mutation_p.G376R|PIK3R1_ENST00000396611.1_Missense_Mutation_p.G376R	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	376	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.G376R(5)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAGGAAAGGGGGAAATAACAA	0.308			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			13	19					0	0	1	0	0	A	67589138	G	A	67589138	3	1	3	1	0	0	0	0	1	0	0	0	11965	1233	43	3	1290	3	PIK3R1	5	67589138	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		67589138	113326122	23	136										
PIK3R1	5295	broad.mit.edu	37	chr5	67592085	67592086	+	Frame_Shift_Ins	INS	-	-	T													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agcagcaaccgaaacaaagcINStgaaaacctgttgcgaggga							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr5:67592085_67592086insT	ENST00000521381.1	+	15	2517_2518	c.1901_1902insT	c.(1900-1902)ggafs	p.G634fs	PIK3R1_ENST00000274335.5_Frame_Shift_Ins_p.G634fs|PIK3R1_ENST00000320694.8_Frame_Shift_Ins_p.G334fs|PIK3R1_ENST00000523872.1_Frame_Shift_Ins_p.G271fs|PIK3R1_ENST00000396611.1_Frame_Shift_Ins_p.G642fs|PIK3R1_ENST00000336483.5_Frame_Shift_Ins_p.G364fs|PIK3R1_ENST00000521657.1_Frame_Shift_Ins_p.G634fs	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	634	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGAAACAAAGCTGAAAACCTGT	0.485			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			45	40	---	---	---	---						T	67592086	-	T	67592085	7	5	3	1	0	1	1	0	0	0	0	0	11965	797	28	0	2085	0	PIK3R1	5	67592085	Frame_Shift_Ins	INS	-	TCGA-N5-A4RD-01A-11D-A28R-08	2947	67592085	113323175	24	137										
PCDHA10	0	broad.mit.edu	37	chr5	140237391	140237391	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gtgctgcggtcggtggttgcGggtcacgtggtggctaaggt	20	7	1	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr5:140237391G>A	ENST00000307360.5	+	1	1758	c.1758G>A	c.(1756-1758)gcG>gcA	p.A586A	PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGGTTGCGGGTCACGTGG	0.662													61	53					0	0	1	0	0	A	140237391	G	A	140237391	2	1	3	1	0	0	0	0	0	0	0	1	11566	1103	39	1		1	PCDHA10	5	140237391	Silent	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	72645306	140237391	40677869	25	138										
EBF1	1879	broad.mit.edu	37	chr5	158140122	158140122	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gggaacactgtacagggcctCggcaatgtcggccgctctct	13	13	1	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr5:158140122C>T	ENST00000313708.6	-	13	1507	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K	EBF1_ENST00000380654.4_Missense_Mutation_p.E378K|EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Missense_Mutation_p.E401K	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	409					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACAGGGCCTCGGCAATGTCG	0.522			T	HMGA2	lipoma								7	34					0	0	1	0	0	T	158140122	C	T	158140122	3	4	3	1	0	0	0	0	1	0	0	0	4906	893	31	1	566	1	EBF1	5	158140122	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	17902731	158140122	22775138	26	139										
CNOT6	57472	broad.mit.edu	37	chr5	179998267	179998268	+	Frame_Shift_Del	DEL	AA	AA	-													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agcacaggtggagtagaaacAaatcacaaagactttaagga							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr5:179998267_179998268delAA	ENST00000393356.1	+	13	1720_1721	c.1296_1297delAA	c.(1294-1299)acatfs	p.TN432fs	CNOT6_ENST00000261951.4_Frame_Shift_Del_p.TN432fs			Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	432					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|skin(1)	23	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		GAGTAGAAACAAATCACAAAGA	0.332													25	23	---	---	---	---						-	179998268	AA	-	179998267	7	5	3	1	0	1	0	1	0	0	0	0	3645	117	5	0	1334	0	CNOT6	5	179998267	Frame_Shift_Del	DEL	AA	TCGA-N5-A4RD-01A-11D-A28R-08	21858145	179998267	916993	27	140										
HIST1H3E	8353	broad.mit.edu	37	chr6	26225539	26225539	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ccgtggctctgcgcgagatcCgtcgctaccagaagtctacc	11	15	2	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr6:26225539C>T	ENST00000360408.1	+	1	157	c.157C>T	c.(157-159)Cgt>Tgt	p.R53C		NM_003532.2	NP_003523.1	P68431	H31_HUMAN	histone cluster 1, H3e	53					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(5)|skin(1)	8		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GCGCGAGATCCGTCGCTACCA	0.627													49	60					0	0	1	0	0	T	26225539	C	T	26225539	3	4	3	1	0	0	0	0	1	0	0	0	7199	652	23	1	159	1	HIST1H3E	6	26225539	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		26225539	144889528	28	141										
LY6G5B	58496	broad.mit.edu	37	chr6	31639652	31639652	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ctccctcagatgtcaaggttCgcttcatcgttcgaggctgt	10	12	3	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr6:31639652C>T	ENST00000375864.4	+	3	983	c.199C>T	c.(199-201)Cgc>Tgc	p.R67C	LY6G5B_ENST00000409525.1_Missense_Mutation_p.R12C|CSNK2B-LY6G5B-1181_ENST00000375880.2_3'UTR	NM_021221.2	NP_067044.2	Q8NDX9	LY65B_HUMAN	lymphocyte antigen 6 complex, locus G5B	67	UPAR/Ly6.					extracellular region				lung(4)	4						TGTCAAGGTTCGCTTCATCGT	0.507													31	45					0	0	1	0	0	T	31639652	C	T	31639652	3	4	3	1	0	0	0	0	1	0	0	0	9137	884	31	1	209	1	LY6G5B	6	31639652	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	5414113	31639652	139475415	29	142										
BAK1	578	broad.mit.edu	37	chr6	33541652	33541652	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agaaccaccagcacgttcagGatgggaccattgcccaagtt	10	12	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr6:33541652G>A	ENST00000374467.3	-	6	812	c.564C>T	c.(562-564)atC>atT	p.I188I	BAK1_ENST00000360661.5_Silent_p.I188I|BAK1_ENST00000442998.2_3'UTR	NM_001188.3	NP_001179.1	Q16611	BAK_HUMAN	BCL2-antagonist/killer 1	188					activation of pro-apoptotic gene products|cellular response to mechanical stimulus|cellular response to UV|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria	integral to mitochondrial outer membrane|pore complex	metal ion binding|protein heterodimerization activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4						GCACGTTCAGGATGGGACCAT	0.567													31	29					0	0	1	0	0	A	33541652	G	A	33541652	2	1	3	1	0	0	0	0	0	0	0	1	1303	1164	41	3		3	BAK1	6	33541652	Silent	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	1902000	33541652	137573415	30	143										
DEF6	50619	broad.mit.edu	37	chr6	35278356	35278356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tctccaatcaggatgccttcCgcctctggtgcctcttcaac	7	16	5	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr6:35278356C>T	ENST00000316637.5	+	3	363	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C	DEF6_ENST00000542066.1_5'UTR	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	120						cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						GGATGCCTTCCGCCTCTGGTG	0.532													34	54					0	0	1	0	0	T	35278356	C	T	35278356	3	4	3	1	0	0	0	0	1	0	0	0	4409	652	23	1	368	1	DEF6	6	35278356	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	1736704	35278356	135836711	31	144										
EYA4	2070	broad.mit.edu	37	chr6	133834153	133834153	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	aagagtaaaagaattatataAcacctacaagaacaacgttg	6	6	0	3			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr6:133834153A>G	ENST00000367895.5	+	16	1942	c.1478A>G	c.(1477-1479)aAc>aGc	p.N493S	EYA4_ENST00000531901.1_Missense_Mutation_p.N499S|EYA4_ENST00000355286.6_Missense_Mutation_p.N470S|EYA4_ENST00000525849.1_Missense_Mutation_p.N470S|EYA4_ENST00000355167.3_Missense_Mutation_p.N493S|EYA4_ENST00000452339.2_Missense_Mutation_p.N439S|RP3-323P13.2_ENST00000607033.1_RNA|EYA4_ENST00000431403.2_Missense_Mutation_p.N493S|EYA4_ENST00000430974.2_Missense_Mutation_p.N445S	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	493					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GAATTATATAACACCTACAAG	0.388													16	20					0	0	1	0	0	G	133834153	A	G	133834153	3	3	3	1	0	0	0	0	1	0	0	0	5359	43	2	4	1536	4	EYA4	6	133834153	Missense_Mutation	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	98555797	133834153	37280914	32	145										
PCLO	27445	broad.mit.edu	37	chr7	82579349	82579349	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agatatctctgctaccgtttGaactgctatgctggagactt	9	9	1	3			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr7:82579349G>C	ENST00000423517.2	-	6	10892	c.10555C>G	c.(10555-10557)Caa>Gaa	p.Q3519E	PCLO_ENST00000437081.1_Missense_Mutation_p.Q239E|PCLO_ENST00000333891.8_Missense_Mutation_p.Q3519E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3450					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCTACCGTTTGAACTGCTATG	0.458													16	26					0	0	1	0	0	C	82579349	G	C	82579349	3	2	3	1	0	0	0	0	1	0	0	0	11629	1299	45	2	4970	2	PCLO	7	82579349	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		82579349	76559314	33	146										
CCDC132	55610	broad.mit.edu	37	chr7	92905543	92905543	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	acaccgtgtttcaagttgttCttggttatgtggaactatgt	10	6	2	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr7:92905543C>T	ENST00000544910.1	+	13	998	c.778C>T	c.(778-780)Ctt>Ttt	p.L260F	CCDC132_ENST00000305866.5_Missense_Mutation_p.L290F|CCDC132_ENST00000535481.1_Intron|CCDC132_ENST00000251739.5_Missense_Mutation_p.L290F|CCDC132_ENST00000541136.1_Missense_Mutation_p.L101F|CCDC132_ENST00000317751.6_Missense_Mutation_p.L21F	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	290										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TCAAGTTGTTCTTGGTTATGT	0.373													23	42					0	0	1	0	0	T	92905543	C	T	92905543	3	4	3	1	0	0	0	0	1	0	0	0	2785	913	32	3	914	3	CCDC132	7	92905543	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	10326194	92905543	66233120	34	147										
GPR37	2861	broad.mit.edu	37	chr7	124386977	124386977	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	actctctagttgaatctgccGtttattccctcgggtacagg	9	11	2	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr7:124386977G>A	ENST00000303921.2	-	2	2094	c.1444C>T	c.(1444-1446)Cgg>Tgg	p.R482W		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	482						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TGAATCTGCCGTTTATTCCCT	0.428													29	31					0	0	1	0	0	A	124386977	G	A	124386977	3	1	3	1	0	0	0	0	1	0	0	0	6730	1144	40	1	401	1	GPR37	7	124386977	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	31481434	124386977	34751686	35	148										
CSMD3	114788	broad.mit.edu	37	chr8	113697868	113697868	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tccctggatcagagattatcGtccagatgcaatttaaatta	7	8	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr8:113697868G>A	ENST00000297405.5	-	15	2493	c.2249C>T	c.(2248-2250)aCg>aTg	p.T750M	CSMD3_ENST00000352409.3_Missense_Mutation_p.T750M|CSMD3_ENST00000343508.3_Missense_Mutation_p.T710M|CSMD3_ENST00000455883.2_Missense_Mutation_p.T646M	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	750	CUB 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGAGATTATCGTCCAGATGCA	0.428										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	45					0	0	1	0	0	A	113697868	G	A	113697868	3	1	3	1	0	0	0	0	1	0	0	0	3971	1145	40	1	9102	1	CSMD3	8	113697868	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		113697868	32666154	36	149										
ZNF572	137209	broad.mit.edu	37	chr8	125989122	125989122	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agcaatacctcccatcttatTatccatgagagaactcacac	4	13	2	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr8:125989122T>G	ENST00000319286.5	+	3	766	c.612T>G	c.(610-612)atT>atG	p.I204M		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCCATCTTATTATCCATGAGA	0.473										HNSCC(60;0.17)			9	92					0	0	1	0	0	G	125989122	T	G	125989122	3	3	3	1	0	0	0	0	1	0	0	0	18060	1742	61	4	618	4	ZNF572	8	125989122	Missense_Mutation	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	12291254	125989122	20374900	37	150										
FRMPD1	22844	broad.mit.edu	37	chr9	37745609	37745609	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	aacccccagggcaaggctgcCaggctcaagaacaaaaacta	9	13	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr9:37745609C>T	ENST00000539465.1	+	16	4173	c.3580C>T	c.(3580-3582)Cag>Tag	p.Q1194*	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Nonsense_Mutation_p.Q1194*			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1194						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GCAAGGCTGCCAGGCTCAAGA	0.522													22	66					0	0	1	0	0	T	37745609	C	T	37745609	4	4	3	1	0	0	0	0	0	1	0	0	6091	595	21	3	3638	3	FRMPD1	9	37745609	Nonsense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		37745609	103467822	38	151										
PCSK5	5125	broad.mit.edu	37	chr9	78790138	78790138	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gaatggaatggaatggaatgAaatggaatggaatgaaatgg	15	0	0	2	rs11999771		TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr9:78790138A>G	ENST00000376767.3	+	14	2505	c.1993A>G	c.(1993-1995)Aaa>Gaa	p.K665E	PCSK5_ENST00000545128.1_Intron|PCSK5_ENST00000376752.4_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						gaatggaatgaaatggaatgg	0.423													3	17					0	0	1	0	0	G	78790138	A	G	78790138	3	3	3	1	0	0	0	0	1	0	0	0	11649	261	9	4		4	PCSK5	9	78790138	Missense_Mutation	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	41044529	78790138	62423293	39	152										
UBXN1	51035	broad.mit.edu	37	chr11	62445085	62445085	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tggtgccactgggggtggctGagagcccacactgccaccat	14	13	0	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr11:62445085G>C	ENST00000294119.2	-	7	687	c.556C>G	c.(556-558)Cag>Gag	p.Q186E	UBXN1_ENST00000301935.5_Missense_Mutation_p.Q186E|UBXN1_ENST00000533000.1_Missense_Mutation_p.Q44E|UBXN1_ENST00000529640.1_Missense_Mutation_p.Q182E|UBXN1_ENST00000524762.1_Intron	NM_015853.3	NP_056937.2	Q04323	UBXN1_HUMAN	UBX domain protein 1	186	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding			endometrium(5)|lung(12)	17						GGGGGTGGCTGAGAGCCCACA	0.547													43	48					0	0	1	0	0	C	62445085	G	C	62445085	3	2	3	1	0	0	0	0	1	0	0	0	16970	1299	45	2	390	2	UBXN1	11	62445085	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		62445085	72561431	40	153										
TPCN2	219931	broad.mit.edu	37	chr11	68854003	68854003	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ctccgcaggtggtccaagatCtattttgtattgtggtggct	12	8	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr11:68854003C>T	ENST00000294309.3	+	23	2117	c.2016C>T	c.(2014-2016)atC>atT	p.I672I	TPCN2_ENST00000442692.2_3'UTR|TPCN2_ENST00000542467.1_Intron	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	672					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGTCCAAGATCTATTTTGTAT	0.547													32	8					0	0	1	0	0	T	68854003	C	T	68854003	2	4	3	1	0	0	0	0	0	0	0	1	16456	903	32	3		3	TPCN2	11	68854003	Silent	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	6408918	68854003	66152513	41	154										
HEPHL1	341208	broad.mit.edu	37	chr11	93800731	93800731	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tggagaatctgtgtcctggcAcctatttggaatggggaatg	14	6	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr11:93800731A>T	ENST00000315765.9	+	5	886	c.878A>T	c.(877-879)cAc>cTc	p.H293L		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	293	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTGTCCTGGCACCTATTTGGA	0.468													53	11					0	0	1	0	0	T	93800731	A	T	93800731	3	4	3	1	0	0	0	0	1	0	0	0	7095	159	6	4	896	4	HEPHL1	11	93800731	Missense_Mutation	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	24946728	93800731	41205785	42	155										
GLB1L3	112937	broad.mit.edu	37	chr11	134179592	134179592	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	atatatgttccatggtggaaCcaactttggtttcatgaacg	9	7	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr11:134179592C>G	ENST00000431683.2	+	11	1034	c.1034C>G	c.(1033-1035)aCc>aGc	p.T345S		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	345					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CATGGTGGAACCAACTTTGGT	0.468													5	4					0	0	1	0	0	G	134179592	C	G	134179592	3	3	3	1	0	0	0	0	1	0	0	0	6471	507	18	5	1076	5	GLB1L3	11	134179592	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	40378861	134179592	826924	43	156										
CHD4	1108	broad.mit.edu	37	chr12	6700659	6700659	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gcggtcaatggcctcttgccGcatgttcccagtgattccac	10	14	2	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr12:6700659G>A	ENST00000309577.6	-	22	3476	c.3313C>T	c.(3313-3315)Cgg>Tgg	p.R1105W	CHD4_ENST00000544484.1_Missense_Mutation_p.R1102W|CHD4_ENST00000357008.2_Missense_Mutation_p.R1105W|CHD4_ENST00000544040.1_Missense_Mutation_p.R1098W			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1105	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding	p.R1105W(1)		central_nervous_system(2)	2						GCCTCTTGCCGCATGTTCCCA	0.433													31	37					0	0	1	0	0	A	6700659	G	A	6700659	3	1	3	1	0	0	0	0	1	0	0	0	3349	1086	38	1	2501	1	CHD4	12	6700659	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		6700659	127151236	44	157										
HOXC13	3229	broad.mit.edu	37	chr12	54333359	54333359	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tgggctctctccaatggctgGgacagtcaggtgtactgctc	13	11	2	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr12:54333359G>C	ENST00000243056.3	+	1	825	c.669G>C	c.(667-669)tgG>tgC	p.W223C	HOXC-AS5_ENST00000512916.2_RNA	NM_017410.2	NP_059106.2	P31276	HXC13_HUMAN	homeobox C13	223						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)|skin(1)	3						CCAATGGCTGGGACAGTCAGG	0.682			T	NUP98	AML								11	24					0	0	1	0	0	C	54333359	G	C	54333359	3	2	3	1	0	0	0	0	1	0	0	0	7352	1241	43	5	671	5	HOXC13	12	54333359	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	47632700	54333359	79518536	45	158										
HELB	92797	broad.mit.edu	37	chr12	66725099	66725099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	acagttttcctagaaaaactCgtttgaaacatttcttgcaa	5	8	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr12:66725099C>T	ENST00000247815.4	+	12	2895	c.2836C>T	c.(2836-2838)Cgt>Tgt	p.R946C		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	946					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TAGAAAAACTCGTTTGAAACA	0.527													9	50					0	0	1	0	0	T	66725099	C	T	66725099	3	4	3	1	0	0	0	0	1	0	0	0	7085	884	31	1	2882	1	HELB	12	66725099	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	12391740	66725099	67126796	46	159										
DNAH10	196385	broad.mit.edu	37	chr12	124402320	124402320	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	catgctggacaatgtggaccTggtgcacaccctggaggaga	14	10	0	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr12:124402320T>A	ENST00000409039.3	+	63	10863	c.10838T>A	c.(10837-10839)cTg>cAg	p.L3613Q		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3613	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AATGTGGACCTGGTGCACACC	0.607													4	2					0	0	1	0	0	A	124402320	T	A	124402320	3	1	3	1	0	0	0	0	1	0	0	0	4626	1580	55	4	11088	4	DNAH10	12	124402320	Missense_Mutation	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	57677221	124402320	9449575	47	160										
KLHL1	57626	broad.mit.edu	37	chr13	70314570	70314570	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	actgtgctccgagcaattgaCatactggctacaaatgtcca	8	11	0	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr13:70314570C>A	ENST00000377844.4	-	8	2517	c.1758G>T	c.(1756-1758)atG>atT	p.M586I	KLHL1_ENST00000545028.1_Missense_Mutation_p.M393I	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	586					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GAGCAATTGACATACTGGCTA	0.393													5	20					0.000602214	0.000602214	1	1	0	A	70314570	C	A	70314570	3	1	3	1	0	0	0	0	1	0	0	0	8407	478	17	5	504	5	KLHL1	13	70314570	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		70314570	44855308	48	161										
PDIA3	2923	broad.mit.edu	37	chr15	44048891	44048891	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	acctgtaataaatatggagtCagtggatatccaaccctgaa	8	8	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr15:44048891C>T	ENST00000300289.5	+	3	439	c.291C>T	c.(289-291)gtC>gtT	p.V97V	PDIA3_ENST00000469684.1_3'UTR|PDIA3_ENST00000538521.1_Silent_p.V77V	NM_005313.4	NP_005304.3	P30101	PDIA3_HUMAN	protein disulfide isomerase family A, member 3	97	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(2)|skin(1)	17		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		AATATGGAGTCAGTGGATATC	0.393													22	36					0	0	1	0	0	T	44048891	C	T	44048891	2	4	3	1	0	0	0	0	0	0	0	1	11715	813	29	3		3	PDIA3	15	44048891	Silent	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		44048891	58482501	49	162										
TELO2	9894	broad.mit.edu	37	chr16	1544439	1544439	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	cgctcccgagggagaaggagGagtttgcctcggcccacttc	14	13	0	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr16:1544439G>A	ENST00000262319.6	+	2	436	c.157G>A	c.(157-159)Gag>Aag	p.E53K		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	53						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				GGAGAAGGAGGAGTTTGCCTC	0.647											OREG0023547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	72	64					0	0	1	0	0	A	1544439	G	A	1544439	3	1	3	1	0	0	0	0	1	0	0	0	15815	1175	41	3	159	3	TELO2	16	1544439	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		1544439	88810314	50	163										
ZFHX3	463	broad.mit.edu	37	chr16	72992232	72992232	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	accctctgtgctttcatttgGttctggtgctgtggcattgt	11	9	3	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr16:72992232G>T	ENST00000268489.5	-	2	2485	c.1813C>A	c.(1813-1815)Cca>Aca	p.P605T	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	605					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CTTTCATTTGGTTCTGGTGCT	0.602													15	41					2.32078e-09	2.37353e-09	1	1	0	T	72992232	G	T	72992232	3	4	3	1	0	0	0	0	1	0	0	0	17691	1261	44	5	9334	5	ZFHX3	16	72992232	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	71447793	72992232	17362521	51	164										
GINS2	51659	broad.mit.edu	37	chr16	85721095	85721095	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tccactctggagggagcaggCgacatttctgtctttgtttc	11	10	3	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr16:85721095C>T	ENST00000253462.3	-	2	276	c.176G>A	c.(175-177)cGc>cAc	p.R59H		NM_016095.2	NP_057179.1	Q9Y248	PSF2_HUMAN	GINS complex subunit 2 (Psf2 homolog)	59					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)	6						AGGGAGCAGGCGACATTTCTG	0.577													43	39					0	0	1	0	0	T	85721095	C	T	85721095	3	4	3	1	0	0	0	0	1	0	0	0	6429	768	27	1	397	1	GINS2	16	85721095	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	12728863	85721095	4633658	52	165										
ZC3H18	124245	broad.mit.edu	37	chr16	88677691	88677691	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	caaaggaaagggagcgggagCgagagagagagaacagacag	18	5	0	4			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr16:88677691C>T	ENST00000301011.5	+	8	1422	c.1222C>T	c.(1222-1224)Cga>Tga	p.R408*	ZC3H18_ENST00000452588.2_Nonsense_Mutation_p.R432*	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	408						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		ggagcgggagcgagagagaga	0.642													15	10					0	0	1	0	0	T	88677691	C	T	88677691	4	4	3	1	0	0	0	0	0	1	0	0	17626	760	27	1	1248	1	ZC3H18	16	88677691	Nonsense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	2956596	88677691	1677062	53	166										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	4					0	0	1	0	0	T	7577538	C	T	7577538	3	4	3	1	0	0	0	0	1	0	0	0	16441	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		7577538	73617672	54	167										
TMEM132E	124842	broad.mit.edu	37	chr17	32964455	32964455	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	cacgacccctgtgggcctgcGggtgcactttgggagggacg	17	12	0	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr17:32964455G>A	ENST00000321639.5	+	10	2487	c.2159G>A	c.(2158-2160)cGg>cAg	p.R720Q		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	720						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTGGGCCTGCGGGTGCACTTT	0.682													33	5					0	0	1	0	0	A	32964455	G	A	32964455	3	1	3	1	0	0	0	0	1	0	0	0	16107	1116	39	1	2197	1	TMEM132E	17	32964455	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	25386917	32964455	48230755	55	168										
ABCA10	10349	broad.mit.edu	37	chr17	67193233	67193233	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gcttctacttttccagtcttTccattatattcttttataac	2	10	3	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr17:67193233T>C	ENST00000269081.4	-	12	2115	c.1206A>G	c.(1204-1206)ggA>ggG	p.G402G	ABCA10_ENST00000416101.2_Silent_p.G402G|ABCA10_ENST00000432313.2_Silent_p.G402G	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	402	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TTCCAGTCTTTCCATTATATT	0.388													4	8					0	0	1	0	0	C	67193233	T	C	67193233	2	2	3	1	0	0	0	0	0	0	0	1	29	1770	62	4		4	ABCA10	17	67193233	Silent	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	34228778	67193233	14001977	56	169										
RECQL5	9400	broad.mit.edu	37	chr17	73661200	73661200	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	aacagagcagggagctgataGcatagggattttcctgcccc	12	10	0	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr17:73661200G>A	ENST00000420326.2	-	3	342	c.183C>T	c.(181-183)tgC>tgT	p.C61C	RECQL5_ENST00000340830.5_Silent_p.C61C|RECQL5_ENST00000423245.2_Intron|RECQL5_ENST00000584999.1_Silent_p.C61C|RECQL5_ENST00000317905.5_Silent_p.C61C	NM_001003715.3|NM_001003716.3	NP_001003715.1|NP_001003716.1	O94762	RECQ5_HUMAN	RecQ protein-like 5	61	Helicase ATP-binding.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			breast(1)|cervix(3)|endometrium(3)|kidney(7)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	36	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GGAGCTGATAGCATAGGGATT	0.473								Other identified genes with known or suspected DNA repair function					84	95					0	0	1	0	0	A	73661200	G	A	73661200	2	1	3	1	0	0	0	0	0	0	0	1	13254	963	34	3		3	RECQL5	17	73661200	Silent	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	6467967	73661200	7534010	57	170										
GATA6	2627	broad.mit.edu	37	chr18	19756993	19756993	+	Frame_Shift_Del	DEL	G	G	-													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	cgccgctgtggcggcgggacGgcaccggccactacctgtgc							TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr18:19756993delG	ENST00000269216.3	+	3	1490	c.1213delG	c.(1213-1215)gcfs	p.G405fs	GATA6_ENST00000581694.1_Frame_Shift_Del_p.G405fs	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	405					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GCGGCGGGACGGCACCGGCCA	0.682													2	4	---	---	---	---						-	19756993	G	-	19756993	7	5	3	1	0	1	0	1	0	0	0	0	6297	1116	39	0	1219	0	GATA6	18	19756993	Frame_Shift_Del	DEL	G	TCGA-N5-A4RD-01A-11D-A28R-08		19756993	58320255	58	171										
SALL3	27164	broad.mit.edu	37	chr18	76756943	76756943	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ccccgcgagacgcggccgccGcctgtctgtggagaacccca	13	18	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr18:76756943G>A	ENST00000536229.3	+	3	3618	c.2909G>A	c.(2908-2910)cGc>cAc	p.R970H	SALL3_ENST00000537592.2_Missense_Mutation_p.R1175H|SALL3_ENST00000575389.2_Missense_Mutation_p.R1103H			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGCGGCCGCCGCCTGTCTGTG	0.612													14	17					0	0	1	0	0	A	76756943	G	A	76756943	3	1	3	1	0	0	0	0	1	0	0	0	13863	1087	38	1	3534	1	SALL3	18	76756943	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	56999950	76756943	1320305	59	172										
MLLT1	4298	broad.mit.edu	37	chr19	6230661	6230661	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ctcgcagcgcaggtggttcaCgggcgggttgccttccaggt	16	12	1	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr19:6230661C>T	ENST00000252674.7	-	4	503	c.340G>A	c.(340-342)Gtg>Atg	p.V114M		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	114					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding	p.V114M(1)		endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						AGGTGGTTCACGGGCGGGTTG	0.612			T	MLL	AL								109	17					0	0	1	0	0	T	6230661	C	T	6230661	3	4	3	1	0	0	0	0	1	0	0	0	9672	536	19	1	1375	1	MLLT1	19	6230661	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08		6230661	52898322	60	173										
ZNF333	84449	broad.mit.edu	37	chr19	14817512	14817512	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gtccagggactgaaggccgcTatgcagattcagagggtggt	16	8	1	3			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr19:14817512T>A	ENST00000601134.1	+	5	377	c.259T>A	c.(259-261)Tat>Aat	p.Y87N	ZNF333_ENST00000540689.2_Silent_p.A146A|ZNF333_ENST00000536363.1_Silent_p.A37A|ZNF333_ENST00000292530.6_Silent_p.A146A			Q96JL9	ZN333_HUMAN	zinc finger protein 333	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|prostate(1)	21						TGAAGGCCGCTATGCAGATTC	0.572													38	7					0	0	1	0	0	A	14817512	T	A	14817512	3	1	3	1	0	0	0	0	1	0	0	0	17906	1509	53	4	460	4	ZNF333	19	14817512	Missense_Mutation	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	8586851	14817512	44311471	61	174										
AP1M1	8907	broad.mit.edu	37	chr19	16317206	16317206	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gctggtcttttctttcctctAtaaggtggtgcaggtgagtc	12	8	3	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr19:16317206A>G	ENST00000291439.3	+	3	703	c.254A>G	c.(253-255)tAt>tGt	p.Y85C	AP1M1_ENST00000429941.2_Missense_Mutation_p.Y85C|AP1M1_ENST00000590756.1_Intron|AP1M1_ENST00000444449.2_Missense_Mutation_p.Y85C|AP1M1_ENST00000541844.1_Intron	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	85					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						TCTTTCCTCTATAAGGTGGTG	0.592													5	210					0	0	1	0	0	G	16317206	A	G	16317206	3	3	3	1	0	0	0	0	1	0	0	0	730	449	16	4	264	4	AP1M1	19	16317206	Missense_Mutation	SNP	A	TCGA-N5-A4RD-01A-11D-A28R-08	1499694	16317206	42811777	62	175										
TNFRSF6B	8771	broad.mit.edu	37	chr20	62329741	62329741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	cgaggccccggagggctgggGtccgacaccaagggcgggcc	19	14	0	0			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr20:62329741G>A	ENST00000369996.1	+	3	828	c.728G>A	c.(727-729)gGt>gAt	p.G243D	RTEL1-TNFRSF6B_ENST00000482936.1_3'UTR	NM_003823.3	NP_003814.1	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily, member 6b, decoy	243					anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|lung(2)|skin(1)	4	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			GAGGGCTGGGGTCCGACACCA	0.706													12	8					0	0	1	0	0	A	62329741	G	A	62329741	3	1	3	1	0	0	0	0	1	0	0	0	16357	1261	44	3	738	3	TNFRSF6B	20	62329741	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		62329741	695779	63	176										
BAGE2	85319	broad.mit.edu	37	chr21	11056763	11056763	+	RNA	DEL	T	T	-													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gtagcactgccattgagtaaTaaaatgttccaatattagag					rs2838178		TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr21:11056763delT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATTGAGTAATAAAATGTTCC	0.299													3	4	---	---	---	---						-	11056763	T	-	11056763	6	5	3	0	1	1	0	1	0	0	0	0	1290	1421	49	0		0	BAGE2	21	11056763	RNA	DEL	T	TCGA-N5-A4RD-01A-11D-A28R-08		11056763	37073132	64	177										
BAGE2	85319	broad.mit.edu	37	chr21	11068974	11068974	+	RNA	DEL	T	T	-													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	aacactgcggcaagcaaagaTtttttaataaagcataaaga					rs147179649		TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr21:11068974delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		caagcaaagattttttaataa	0.279													3	6	---	---	---	---						-	11068974	T	-	11068974	6	5	3	0	1	1	0	1	0	0	0	0	1290	1508	52	0		0	BAGE2	21	11068974	RNA	DEL	T	TCGA-N5-A4RD-01A-11D-A28R-08	12211	11068974	37060921	65	178										
BAGE2	85319	broad.mit.edu	37	chr21	11071214	11071215	+	RNA	INS	-	-	C													0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agagagagggcagaccaattINSagggcttcaggtgccaagaa					rs113940337		TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chr21:11071214_11071215insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gcagaccaattagggcttcagg	0.406													3	5	---	---	---	---						C	11071215	-	C	11071214	6	5	3	0	1	1	1	0	0	0	0	0	1290	1769	61	0		0	BAGE2	21	11071214	RNA	INS	-	TCGA-N5-A4RD-01A-11D-A28R-08	2240	11071214	37058681	66	179										
PRICKLE3	4007	broad.mit.edu	37	chrX	49032095	49032095	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agtccctggggagcgataaaGatggggagttgaaggtctcc	16	7	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chrX:49032095G>T	ENST00000376317.3	-	9	1869	c.1775C>A	c.(1774-1776)tCt>tAt	p.S592Y	PRICKLE3_ENST00000538114.1_Missense_Mutation_p.S416Y|PRICKLE3_ENST00000536904.1_Missense_Mutation_p.S511Y|PRICKLE3_ENST00000540849.1_Missense_Mutation_p.S524Y	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	592							protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						GAGCGATAAAGATGGGGAGTT	0.612													159	272					2.76239e-48	3.0319e-48	1	1	0	T	49032095	G	T	49032095	3	4	3	1	0	0	0	0	1	0	0	0	12539	942	33	2	76	2	PRICKLE3	23	49032095	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08		49032095	106238465	67	180			1	2		3	3	1247	G		3.958474e-06
PRICKLE3	4007	broad.mit.edu	37	chrX	49032106	49032106	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	agcgataaagatggggagttGaaggtctccattgcagtgtc	14	6	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chrX:49032106G>T	ENST00000376317.3	-	9	1858	c.1764C>A	c.(1762-1764)ttC>ttA	p.F588L	PRICKLE3_ENST00000538114.1_Missense_Mutation_p.F412L|PRICKLE3_ENST00000536904.1_Missense_Mutation_p.F507L|PRICKLE3_ENST00000540849.1_Missense_Mutation_p.F520L	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	588							protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						ATGGGGAGTTGAAGGTCTCCA	0.592													166	293					2.43961e-46	2.64536e-46	1	1	0	T	49032106	G	T	49032106	3	4	3	1	0	0	0	0	1	0	0	0	12539	1281	45	2	87	2	PRICKLE3	23	49032106	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	11	49032106	106238454	68	181			1	2		3	3	1247	G		3.958474e-06
PRICKLE3	4007	broad.mit.edu	37	chrX	49033341	49033341	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	ctgtggaggctgcaagtgggGctgtgacagggccggcactc	18	10	0	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chrX:49033341G>T	ENST00000376317.3	-	8	1260	c.1166C>A	c.(1165-1167)gCc>gAc	p.A389D	PRICKLE3_ENST00000538114.1_Intron|PRICKLE3_ENST00000536904.1_Missense_Mutation_p.A308D|PRICKLE3_ENST00000540849.1_Missense_Mutation_p.A321D	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	389				Missing (in Ref. 5; AAB92357).			protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						TGCAAGTGGGGCTGTGACAGG	0.647													54	76					5.82388e-19	6.02471e-19	1	1	0	T	49033341	G	T	49033341	3	4	3	1	0	0	0	0	1	0	0	0	12539	1203	42	5	689	5	PRICKLE3	23	49033341	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	1235	49033341	106237219	69	182			1	2		3	3	1247	G		3.958474e-06
KLHL4	0	broad.mit.edu	37	chrX	86887422	86887422	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	tgcctcccatgtcaacacatCggcacggcttaggtaagagc	10	13	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chrX:86887422C>T	ENST00000373119.4	+	7	1682	c.1537C>T	c.(1537-1539)Cgg>Tgg	p.R513W	KLHL4_ENST00000373114.4_Missense_Mutation_p.R513W	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	513						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GTCAACACATCGGCACGGCTT	0.368													6	18					0	0	1	0	0	T	86887422	C	T	86887422	3	4	3	1	0	0	0	0	1	0	0	0	8433	875	31	1	1563	1	KLHL4	23	86887422	Missense_Mutation	SNP	C	TCGA-N5-A4RD-01A-11D-A28R-08	37854081	86887422	68383138	70	183										
XKRX	402415	broad.mit.edu	37	chrX	100169415	100169415	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gctggtgacagcagacacaaTggaggtagtctactacatta	11	8	1	2			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chrX:100169415T>A	ENST00000328526.5	-	3	1866	c.1301A>T	c.(1300-1302)cAt>cTt	p.H434L	XKRX_ENST00000468904.1_3'UTR|XKRX_ENST00000372956.2_Missense_Mutation_p.H421L	NM_212559.2	NP_997724.2	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	421						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						GCAGACACAATGGAGGTAGTC	0.458													4	193					0	0	1	0	0	A	100169415	T	A	100169415	3	1	3	1	0	0	0	0	1	0	0	0	17498	1464	51	4	91	4	XKRX	23	100169415	Missense_Mutation	SNP	T	TCGA-N5-A4RD-01A-11D-A28R-08	13281993	100169415	55101145	71	184										
PNMA3	29944	broad.mit.edu	37	chrX	152226673	152226673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.142857142857143	10	0.401168445648911	1.90771960958296	4.80745341614907	1.51586368977673	0.213756898640463	0.812276214833759	0	gctatagctgtggggaagacGgccacatcagggtacagtgc	15	9	1	1			TCGA-N5-A4RD-01A-11D-A28R-08	TCGA-N5-A4RD-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe34f43-2bce-4a6d-ad0d-7e577ba98ed5	cd3a0e8f-8fe3-42bb-9c1e-d7191c8f1ab9	g.chrX:152226673G>A	ENST00000447306.1	+	2	1597	c.1261G>A	c.(1261-1263)Ggc>Agc	p.G421S	PNMA3_ENST00000370265.4_Missense_Mutation_p.G421S|PNMA3_ENST00000370264.4_Missense_Mutation_p.G421S	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	421					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					TGGGGAAGACGGCCACATCAG	0.572													74	114					0	0	1	0	0	A	152226673	G	A	152226673	3	1	3	1	0	0	0	0	1	0	0	0	12202	1116	39	1	1263	1	PNMA3	23	152226673	Missense_Mutation	SNP	G	TCGA-N5-A4RD-01A-11D-A28R-08	52057258	152226673	3043887	72	185										
ARID1A	8289	broad.mit.edu	37	chr1	27057894	27057894	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cagcagtccccggctccataCccctcccagcagtcgacgac	8	20	0	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:27057894C>G	ENST00000324856.7	+	3	1973	c.1602C>G	c.(1600-1602)taC>taG	p.Y534*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Y151*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Y534*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	534					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CGGCTCCATACCCCTCCCAGC	0.632			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								230	311					0	0	1	0	0	G	27057894	C	G	27057894	4	3	4	1	0	0	0	0	0	1	0	0	910	518	18	5	1612	5	ARID1A	1	27057894	Nonsense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		27057894	222192727	1	186										
SCP2	6342	broad.mit.edu	37	chr1	53416540	53416540	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctactgctttgtttatggccCgccagctgattcagggtggt	12	10	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:53416540C>G	ENST00000371514.3	+	4	481	c.313C>G	c.(313-315)Cgc>Ggc	p.R105G	SCP2_ENST00000371513.5_Intron|SCP2_ENST00000371509.4_Intron|SCP2_ENST00000407246.2_Missense_Mutation_p.R81G|SCP2_ENST00000528311.1_Missense_Mutation_p.R24G	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	105					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						GTTTATGGCCCGCCAGCTGAT	0.403													57	32					0	0	1	0	0	G	53416540	C	G	53416540	3	3	4	1	0	0	0	0	1	0	0	0	13987	652	23	5	327	5	SCP2	1	53416540	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	26358646	53416540	195834081	2	187										
WDR63	126820	broad.mit.edu	37	chr1	85555917	85555918	+	Splice_Site	INS	-	-	A													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	taacaatgcatccataaggtINSaaaaaattgcatattaaatt							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:85555917_85555918insA	ENST00000294664.6	+	8	1037		c.e8+2		WDR63_ENST00000326813.8_Intron|WDR63_ENST00000370596.1_Intron	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63											NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		ATCCATAAGGTAAAAAATTGCa	0.267													17	16	---	---	---	---						A	85555918	-	A	85555917	8	5	4	1	0	1	1	0	0	0	1	0	17373	1652	57	0	885	0	WDR63	1	85555917	Splice_Site	INS	-	TCGA-N5-A4RF-01A-11D-A28R-08	32139377	85555917	163694704	3	188										
KCND3	3752	broad.mit.edu	37	chr1	112319736	112319736	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gcgagtagctggcaggttagAattgggcaggtgtgtggtct	18	5	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:112319736A>G	ENST00000369697.1	-	5	1690	c.1621T>C	c.(1621-1623)Tct>Cct	p.S541P	KCND3_ENST00000315987.2_Missense_Mutation_p.S560P|KCND3_ENST00000302127.4_Missense_Mutation_p.S541P			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	560						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCAGGTTAGAATTGGGCAGG	0.592													15	71					0	0	1	0	0	G	112319736	A	G	112319736	3	3	4	1	0	0	0	0	1	0	0	0	8063	246	9	4	297	4	KCND3	1	112319736	Missense_Mutation	SNP	A	TCGA-N5-A4RF-01A-11D-A28R-08	26763819	112319736	136930885	4	189										
SEC22B	9554	broad.mit.edu	37	chr1	145109259	145109260	+	RNA	INS	-	-	A													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	atgccactgcactccagcccINSgggggcagagcgagactccg					rs61810755	by1000genomes	TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:145109259_145109260insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										cactccagcccgggggcagagc	0.48													2	4	---	---	---	---						A	145109260	-	A	145109259	6	5	4	0	1	1	1	0	0	0	0	0	14042	667	23	0		0	SEC22B	1	145109259	RNA	INS	-	TCGA-N5-A4RF-01A-11D-A28R-08	32789523	145109259	104141362	5	190										
CD247	919	broad.mit.edu	37	chr1	167400923	167400923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gaaatcccctggctgttagcGagggggcagggcctgcatgt	16	10	0	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:167400923G>A	ENST00000392122.3	-	8	631	c.487C>T	c.(487-489)Cgc>Tgc	p.R163C	CD247_ENST00000362089.5_Missense_Mutation_p.R164C|CD247_ENST00000483825.1_5'UTR	NM_000734.3|NM_198053.2	NP_000725.1|NP_932170.1	P20963	CD3Z_HUMAN	CD247 molecule	164					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(543;0.236)			GGCTGTTAGCGAGGGGGCAGG	0.537													16	93					0	0	1	0	0	A	167400923	G	A	167400923	3	1	4	1	0	0	0	0	1	0	0	0	3010	1058	37	1	8	1	CD247	1	167400923	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	22291664	167400923	81849698	6	191										
DARS2	55157	broad.mit.edu	37	chr1	173810047	173810047	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tagaaacacagagattggatTtcttcaagatgcacttagta	8	6	2	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:173810047T>G	ENST00000361951.4	+	11	1791	c.1064T>G	c.(1063-1065)tTt>tGt	p.F355C	DARS2_ENST00000239457.5_5'UTR	NM_018122.4	NP_060592.2	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	355					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			breast(4)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	30					L-Aspartic Acid(DB00128)	GAGATTGGATTTCTTCAAGAT	0.338													11	47					0	0	1	0	0	G	173810047	T	G	173810047	3	3	4	1	0	0	0	0	1	0	0	0	4266	1841	64	4	1106	4	DARS2	1	173810047	Missense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08	6409124	173810047	75440574	7	192										
FAM71A	149647	broad.mit.edu	37	chr1	212798594	212798594	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	accaggcttctgcccctgagGtttgtacggatctctgttca	10	12	3	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:212798594G>A	ENST00000294829.3	+	1	806	c.375G>A	c.(373-375)agG>agA	p.R125R	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	125										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TGCCCCTGAGGTTTGTACGGA	0.527													19	105					0	0	1	0	0	A	212798594	G	A	212798594	2	1	4	1	0	0	0	0	0	0	0	1	5641	1252	44	3		3	FAM71A	1	212798594	Silent	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	38988547	212798594	36452027	8	193										
RGS7	6000	broad.mit.edu	37	chr1	241094033	241094033	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgaccataatctgtgttttcCggctcccaacaatttgatgg	8	10	1	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr1:241094033C>T	ENST00000366565.1	-	6	750	c.369G>A	c.(367-369)ccG>ccA	p.P123P	RGS7_ENST00000366563.1_Silent_p.P123P|RGS7_ENST00000407727.1_Silent_p.P123P|RGS7_ENST00000401882.1_Intron|RGS7_ENST00000348120.2_Intron|RGS7_ENST00000366562.4_Silent_p.P123P|RGS7_ENST00000366564.1_Silent_p.P123P|RGS7_ENST00000446183.2_Silent_p.P39P|RGS7_ENST00000331110.7_Silent_p.P97P	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	123					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CTGTGTTTTCCGGCTCCCAAC	0.388													115	41					0	0	1	0	0	T	241094033	C	T	241094033	2	4	4	1	0	0	0	0	0	0	0	1	13359	639	23	1		1	RGS7	1	241094033	Silent	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	28295439	241094033	8156588	9	194										
TRMT61B	55006	broad.mit.edu	37	chr2	29084138	29084138	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ccagatcatggtggtcttttCgtacctcaaaacttatgact	7	10	3	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr2:29084138C>T	ENST00000306108.5	-	3	862	c.839G>A	c.(838-840)cGa>cAa	p.R280Q	TRMT61B_ENST00000484060.1_5'UTR	NM_017910.3	NP_060380.3	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B (S. cerevisiae)	280							tRNA (adenine-N1-)-methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	13						GTGGTCTTTTCGTACCTCAAA	0.318													9	33					0	0	1	0	0	T	29084138	C	T	29084138	3	4	4	1	0	0	0	0	1	0	0	0	16630	884	31	1	614	1	TRMT61B	2	29084138	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		29084138	214115235	10	195										
FER1L5	90342	broad.mit.edu	37	chr2	97355483	97355483	+	RNA	DEL	A	A	-													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgggggcctgccgccatcccAaacacagacgtggtgagcag							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr2:97355483delA	ENST00000457909.1	+	0	1087							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						CCGCCATCCCAAACACAGACG	0.642													2	4	---	---	---	---						-	97355483	A	-	97355483	6	5	4	0	1	1	0	1	0	0	0	0	5846	117	5	0		0	FER1L5	2	97355483	RNA	DEL	A	TCGA-N5-A4RF-01A-11D-A28R-08	68271345	97355483	145843890	11	196										
ZSWIM2	151112	broad.mit.edu	37	chr2	187702052	187702052	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cttataacacttcccctcaaTtggaaactgtttgcagttat	5	10	1	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr2:187702052T>C	ENST00000295131.2	-	5	763	c.724A>G	c.(724-726)Att>Gtt	p.I242V		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	242					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TTCCCCTCAATTGGAAACTGT	0.368													69	17					0	0	1	0	0	C	187702052	T	C	187702052	3	2	4	1	0	0	0	0	1	0	0	0	18280	1493	52	4	1197	4	ZSWIM2	2	187702052	Missense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08	90346569	187702052	55497321	12	197										
DNAH7	56171	broad.mit.edu	37	chr2	196851841	196851841	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ttttagctagaagtttcccaCaaataatatctgctcgcttc	5	10	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr2:196851841C>G	ENST00000312428.6	-	14	1803	c.1703G>C	c.(1702-1704)tGt>tCt	p.C568S		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	568	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAGTTTCCCACAAATAATATC	0.328													6	44					0	0	1	0	0	G	196851841	C	G	196851841	3	3	4	1	0	0	0	0	1	0	0	0	4633	478	17	5	10579	5	DNAH7	2	196851841	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	9149789	196851841	46347532	13	198										
TTC21A	199223	broad.mit.edu	37	chr3	39150702	39150702	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aagcctatggagtcctcaaaGaaggtaaggacttggcagtg	13	7	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr3:39150702G>T	ENST00000301819.6	+	2	331	c.154G>T	c.(154-156)Gaa>Taa	p.E52*	TTC21A_ENST00000440121.1_Nonsense_Mutation_p.E52*|TTC21A_ENST00000431162.2_Nonsense_Mutation_p.E52*	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	52							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AGTCCTCAAAGAAGGTAAGGA	0.502													31	4					3.73148e-12	4.09376e-12	1	1	0	T	39150702	G	T	39150702	4	4	4	1	0	0	0	0	0	1	0	0	16748	943	33	2	160	2	TTC21A	3	39150702	Nonsense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		39150702	158871728	14	199										
ROBO2	6092	broad.mit.edu	37	chr3	77542517	77542517	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ggtggaaaaaggatgatgcaGacttgccaagaggaaggtaa	15	4	0	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr3:77542517G>C	ENST00000461745.1	+	5	1690	c.790G>C	c.(790-792)Gac>Cac	p.D264H	ROBO2_ENST00000332191.8_Missense_Mutation_p.D264H|ROBO2_ENST00000487694.3_Missense_Mutation_p.D280H	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	264	Ig-like C2-type 3.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGATGATGCAGACTTGCCAAG	0.418													43	6					0	0	1	0	0	C	77542517	G	C	77542517	3	2	4	1	0	0	0	0	1	0	0	0	13565	942	33	2	810	2	ROBO2	3	77542517	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	38391815	77542517	120479913	15	200										
ALCAM	214	broad.mit.edu	37	chr3	105258906	105258906	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cactcttaaatgcttagggaAtggcaaccctcccccagagg	9	13	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr3:105258906A>G	ENST00000306107.5	+	7	1318	c.818A>G	c.(817-819)aAt>aGt	p.N273S	ALCAM_ENST00000389927.4_Intron|ALCAM_ENST00000486979.2_Missense_Mutation_p.N222S|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000472644.2_Missense_Mutation_p.N273S	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	273	Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						TGCTTAGGGAATGGCAACCCT	0.398													40	8					0	0	1	0	0	G	105258906	A	G	105258906	3	3	4	1	0	0	0	0	1	0	0	0	484	101	4	4	844	4	ALCAM	3	105258906	Missense_Mutation	SNP	A	TCGA-N5-A4RF-01A-11D-A28R-08	27716389	105258906	92763524	16	201										
TNIK	23043	broad.mit.edu	37	chr3	170802094	170802094	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tttggcctgttcttgcctaaGaagttcgctagtaaacagag	10	8	1	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr3:170802094G>T	ENST00000436636.2	-	26	3363	c.3019C>A	c.(3019-3021)Ctt>Att	p.L1007I	TNIK_ENST00000369326.5_Missense_Mutation_p.L985I|TNIK_ENST00000470834.1_Missense_Mutation_p.L970I|TNIK_ENST00000460047.1_Missense_Mutation_p.L944I|TNIK_ENST00000357327.5_Missense_Mutation_p.L978I|TNIK_ENST00000341852.6_Missense_Mutation_p.L923I|TNIK_ENST00000538048.1_Missense_Mutation_p.L959I|TNIK_ENST00000488470.1_Missense_Mutation_p.L952I|TNIK_ENST00000284483.8_Missense_Mutation_p.L999I|TNIK_ENST00000475336.1_Missense_Mutation_p.L915I	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1007	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCTTGCCTAAGAAGTTCGCTA	0.398													67	16					9.2564e-22	1.05654e-21	1	1	0	T	170802094	G	T	170802094	3	4	4	1	0	0	0	0	1	0	0	0	16372	942	33	2	1095	2	TNIK	3	170802094	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	65543188	170802094	27220336	17	202										
PIK3CA	5290	broad.mit.edu	37	chr3	178916930	178916930	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aaaagtaattgaaccagtagGcaaccgtgaagaaaagatcc	9	7	0	4			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr3:178916930G>T	ENST00000263967.3	+	2	474	c.317G>T	c.(316-318)gGc>gTc	p.G106V		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	106	PI3K-ABD.		G -> V (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G106V(6)|p.G106_R108delGNR(2)|p.G106_R108del(2)|p.G106A(1)|p.E103_G106>D(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAACCAGTAGGCAACCGTGAA	0.348		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			33	11					1.26612e-14	1.40266e-14	1	1	0	T	178916930	G	T	178916930	3	4	4	1	0	0	0	0	1	0	0	0	11960	1203	42	5	319	5	PIK3CA	3	178916930	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	8114836	178916930	19105500	18	203										
MUC4	4585	broad.mit.edu	37	chr3	195511382	195511382	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgtggatactgaggaagcgtCggtgacatgaagaggggtgg	19	4	0	4			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr3:195511382C>T	ENST00000463781.3	-	2	7528	c.7069G>A	c.(7069-7071)Gac>Aac	p.D2357N	MUC4_ENST00000475231.1_Missense_Mutation_p.D2357N|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	116					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAGCGTCGGTGACATGA	0.592													3	13					0	0	1	0	0	T	195511382	C	T	195511382	3	4	4	1	0	0	0	0	1	0	0	0	10025	884	31	1		1	MUC4	3	195511382	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	16594452	195511382	2511048	19	204										
ADCY2	108	broad.mit.edu	37	chr5	7727300	7727300	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cgggccacggcactgccagcGttcaagtattatgtgacttg	12	11	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:7727300G>A	ENST00000338316.4	+	14	1886	c.1797G>A	c.(1795-1797)gcG>gcA	p.A599A	RP11-711G10.1_ENST00000514105.2_RNA|ADCY2_ENST00000537121.1_Silent_p.A419A	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	599					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CACTGCCAGCGTTCAAGTATT	0.502													25	44					0	0	1	0	0	A	7727300	G	A	7727300	2	1	4	1	0	0	0	0	0	0	0	1	293	1132	40	1		1	ADCY2	5	7727300	Silent	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		7727300	173187960	20	205										
SEMA5A	9037	broad.mit.edu	37	chr5	9052093	9052093	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctggcgggcgcggacttggaCgccagaggcttcacactcag	15	13	2	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:9052093C>T	ENST00000382496.5	-	20	3402	c.2737G>A	c.(2737-2739)Gtc>Atc	p.V913I		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	913	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CGGACTTGGACGCCAGAGGCT	0.602													6	16					0	0	1	0	0	T	9052093	C	T	9052093	3	4	4	1	0	0	0	0	1	0	0	0	14090	536	19	1	503	1	SEMA5A	5	9052093	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	1324793	9052093	171863167	21	206										
SEMA5A	9037	broad.mit.edu	37	chr5	9202131	9202131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gaagaaagtactctgcaattCgttgtagtaaaaggggactt	11	5	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:9202131C>T	ENST00000382496.5	-	9	1533	c.868G>A	c.(868-870)Gaa>Aaa	p.E290K		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	290	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane		p.E290K(1)		biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CTCTGCAATTCGTTGTAGTAA	0.478													20	40					0	0	1	0	0	T	9202131	C	T	9202131	3	4	4	1	0	0	0	0	1	0	0	0	14090	893	31	1	2416	1	SEMA5A	5	9202131	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	150038	9202131	171713129	22	207										
CMYA5	202333	broad.mit.edu	37	chr5	79025483	79025483	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tagaggataaagtaaaagagGtttttccaccctggagaggc	12	6	0	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:79025483G>T	ENST00000446378.2	+	2	926	c.895G>T	c.(895-897)Gtt>Ttt	p.V299F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	299						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGTAAAAGAGGTTTTTCCACC	0.408													16	44					0.0438628	0.0442544	1	1	0	T	79025483	G	T	79025483	3	4	4	1	0	0	0	0	1	0	0	0	3613	1261	44	5	901	5	CMYA5	5	79025483	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	69823352	79025483	101889777	23	208										
PCDHA2	0	broad.mit.edu	37	chr5	140176607	140176607	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tcgcgggcgtgggtgggcgcCgcgggctcagaggctacgct	20	12	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:140176607C>T	ENST00000526136.1	+	1	2058	c.2058C>T	c.(2056-2058)gcC>gcT	p.A686A	PCDHA2_ENST00000378132.1_Silent_p.A686A|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Silent_p.A686A	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGGCGCCGCGGGCTCAG	0.642													66	113					0	0	1	0	0	T	140176607	C	T	140176607	2	4	4	1	0	0	0	0	0	0	0	1	11570	639	23	1		1	PCDHA2	5	140176607	Silent	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	61151124	140176607	40738653	24	209										
PCDHA7	0	broad.mit.edu	37	chr5	140216127	140216127	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	taccctgctgctgtacacggCgttgcggtgctcagcgccgt	13	14	1	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:140216127C>T	ENST00000525929.1	+	1	2159	c.2159C>T	c.(2158-2160)gCg>gTg	p.A720V	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.A720V	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTACACGGCGTTGCGGTGC	0.617													70	45					0	0	1	0	0	T	140216127	C	T	140216127	3	4	4	1	0	0	0	0	1	0	0	0	11575	768	27	1	2161	1	PCDHA7	5	140216127	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	39520	140216127	40699133	25	210										
GRIA1	0	broad.mit.edu	37	chr5	153149914	153149914	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aaccctgtgacaccatgaagGtgggaggtaacttggattcc	12	9	0	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr5:153149914G>A	ENST00000285900.5	+	13	2552	c.2209G>A	c.(2209-2211)Gtg>Atg	p.V737M	GRIA1_ENST00000340592.5_Missense_Mutation_p.V737M|GRIA1_ENST00000518783.1_Missense_Mutation_p.V747M|GRIA1_ENST00000521843.2_Missense_Mutation_p.V668M|GRIA1_ENST00000518142.1_Missense_Mutation_p.V657M|GRIA1_ENST00000448073.4_Missense_Mutation_p.V747M	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	737					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CACCATGAAGGTGGGAGGTAA	0.502													22	41					0	0	1	0	0	A	153149914	G	A	153149914	3	1	4	1	0	0	0	0	1	0	0	0	6807	1261	44	3	2259	3	GRIA1	5	153149914	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	12933787	153149914	27765346	26	211										
MOCS1	4337	broad.mit.edu	37	chr6	39883911	39883911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctgaagctggggcagtagccGggccaggttgatgccattgg	17	9	0	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr6:39883911G>A	ENST00000373186.4	-	3	621	c.484C>T	c.(484-486)Cgg>Tgg	p.R162W	MOCS1_ENST00000432280.2_Missense_Mutation_p.R133W|MOCS1_ENST00000340692.5_Missense_Mutation_p.R162W|MOCS1_ENST00000373175.4_Missense_Mutation_p.R133W|MOCS1_ENST00000425303.2_Missense_Mutation_p.R162W|MOCS1_ENST00000373188.2_Missense_Mutation_p.R162W|MOCS1_ENST00000373195.3_Missense_Mutation_p.R75W|MOCS1_ENST00000308559.7_Missense_Mutation_p.R162W	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	162	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGCAGTAGCCGGGCCAGGTTG	0.572													15	30					0	0	1	0	0	A	39883911	G	A	39883911	3	1	4	1	0	0	0	0	1	0	0	0	9738	1115	39	1	701	1	MOCS1	6	39883911	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		39883911	131231156	27	212										
EFHC1	114327	broad.mit.edu	37	chr6	52318996	52318996	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ggatgatacggtggaaattcGagaggtccacgaacggaatg	15	6	0	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr6:52318996G>A	ENST00000371068.5	+	5	930	c.827G>A	c.(826-828)cGa>cAa	p.R276Q	EFHC1_ENST00000433625.2_Missense_Mutation_p.R185Q|EFHC1_ENST00000538167.1_Missense_Mutation_p.R257Q	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	276	DM10 2.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					GTGGAAATTCGAGAGGTCCAC	0.443													26	92					0	0	1	0	0	A	52318996	G	A	52318996	3	1	4	1	0	0	0	0	1	0	0	0	4972	1058	37	1	855	1	EFHC1	6	52318996	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	12435085	52318996	118796071	28	213										
SYNE1	23345	broad.mit.edu	37	chr6	152706811	152706812	+	Frame_Shift_Ins	INS	-	-	A													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tctgttcatttcctgaccttINSaatttttgataactttttct							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr6:152706811_152706812insA	ENST00000367255.5	-	55	9250_9251	c.8649_8650insT	c.(8647-8652)ataggafs	p.G2884fs	SYNE1_ENST00000423061.1_Frame_Shift_Ins_p.G2891fs|SYNE1_ENST00000265368.4_Frame_Shift_Ins_p.G2884fs|SYNE1_ENST00000341594.5_Frame_Shift_Ins_p.G2923fs|SYNE1_ENST00000448038.1_Frame_Shift_Ins_p.G2891fs	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2884					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCCTGACCTTAATTTTTGATA	0.356										HNSCC(10;0.0054)			24	44	---	---	---	---						A	152706812	-	A	152706811	7	5	4	1	0	1	1	0	0	0	0	0	15501	1763	61	0	18184	0	SYNE1	6	152706811	Frame_Shift_Ins	INS	-	TCGA-N5-A4RF-01A-11D-A28R-08	100387815	152706811	18408256	29	214										
INTS1	26173	broad.mit.edu	37	chr7	1527374	1527374	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tcccgacggcaggcgcagggCggggctgtgtgggctgcgta	20	11	0	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr7:1527374C>T	ENST00000389470.4	-	20	2921	c.2922G>A	c.(2920-2922)ccG>ccA	p.P974P	INTS1_ENST00000404767.3_Intron			Q8N201	INT1_HUMAN	integrator complex subunit 1	839					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGGCGCAGGGCGGGGCTGTGT	0.687													15	9					0	0	1	0	0	T	1527374	C	T	1527374	2	4	4	1	0	0	0	0	0	0	0	1	7818	783	27	1		1	INTS1	7	1527374	Silent	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		1527374	157611289	30	215										
ICA1	3382	broad.mit.edu	37	chr7	8258022	8258022	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aatagtgctcctctatattcCgtcctgcactgttccatgcg	7	13	1	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr7:8258022C>T	ENST00000402384.3	-	6	758	c.492G>A	c.(490-492)acG>acA	p.T164T	ICA1_ENST00000406470.2_Silent_p.T164T|ICA1_ENST00000401396.1_Silent_p.T152T|ICA1_ENST00000396675.3_Silent_p.T164T|ICA1_ENST00000407906.1_Silent_p.T164T|ICA1_ENST00000422063.2_Silent_p.T164T|ICA1_ENST00000265577.7_Silent_p.T163T			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	164	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CTCTATATTCCGTCCTGCACT	0.478													40	72					0	0	1	0	0	T	8258022	C	T	8258022	2	4	4	1	0	0	0	0	0	0	0	1	7520	639	23	1		1	ICA1	7	8258022	Silent	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	6730648	8258022	150880641	31	216										
RELN	5649	broad.mit.edu	37	chr7	103281026	103281026	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgcactgtcctctgccagaaCagaatttgagacatgacggg	11	10	1	4			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr7:103281026C>A	ENST00000428762.1	-	17	2192	c.2033G>T	c.(2032-2034)tGt>tTt	p.C678F	RELN_ENST00000343529.5_Missense_Mutation_p.C678F|RELN_ENST00000424685.2_Missense_Mutation_p.C678F	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	678	EGF-like 1.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTGCCAGAACAGAATTTGAG	0.368													15	8					1.3612e-06	1.42422e-06	1	1	0	A	103281026	C	A	103281026	3	1	4	1	0	0	0	0	1	0	0	0	13271	478	17	5	8545	5	RELN	7	103281026	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	95023004	103281026	55857637	32	217										
C7orf49	78996	broad.mit.edu	37	chr7	134853626	134853626	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgtagccacctgggctgtcaGccatgagggaaggaccctcg	14	12	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr7:134853626G>A	ENST00000430372.1	-	2	330	c.5C>T	c.(4-6)gCt>gTt	p.A2V	C7orf49_ENST00000424142.1_5'UTR|C7orf49_ENST00000483029.2_Intron|C7orf49_ENST00000459937.1_5'UTR|C7orf49_ENST00000393114.3_Silent_p.L17L	NM_001243751.1|NM_024033.3	NP_001230680.1|NP_076938.2	Q9BWK5	MRI_HUMAN	chromosome 7 open reading frame 49	0						cytoplasm				endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						TGGGCTGTCAGCCATGAGGGA	0.527											OREG0018340	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	57					0	0	1	0	0	A	134853626	G	A	134853626	3	1	4	1	0	0	0	0	1	0	0	0	2414	962	34	3	436	3	C7orf49	7	134853626	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	31572600	134853626	24285037	33	218										
NUP205	23165	broad.mit.edu	37	chr7	135323338	135323338	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	taatggaatattgccagtcaCtcatgttacagagttcccct	7	10	2	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr7:135323338C>T	ENST00000285968.6	+	38	5325	c.5299C>T	c.(5299-5301)Ctc>Ttc	p.L1767F		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1767					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TTGCCAGTCACTCATGTTACA	0.408													37	94					0	0	1	0	0	T	135323338	C	T	135323338	3	4	4	1	0	0	0	0	1	0	0	0	10806	565	20	3	5449	3	NUP205	7	135323338	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	469712	135323338	23815325	34	219										
SSPO	23145	broad.mit.edu	37	chr7	149518605	149518605	+	RNA	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cactcgctcccgcaccctggGggacagctggctgcaggggg	16	15	0	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr7:149518605G>A	ENST00000378016.2	+	0	12674							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCACCCTGGGGGACAGCTGG	0.721													4	6					0	0	1	0	0	A	149518605	G	A	149518605	1	1	4	0	1	0	0	0	0	0	0	0	15244	1232	43	3		3	SSPO	7	149518605	RNA	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	14195267	149518605	9620058	35	220										
WWP1	11059	broad.mit.edu	37	chr8	87454894	87454894	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aagttttgaacccaatgtatTgcttatttgagtatgcgggc	10	6	0	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr8:87454894T>C	ENST00000517970.1	+	18	2192	c.1885T>C	c.(1885-1887)Tgc>Cgc	p.C629R	WWP1_ENST00000265428.4_Missense_Mutation_p.C629R|WWP1_ENST00000341922.2_Missense_Mutation_p.C499R|WWP1_ENST00000349423.2_Missense_Mutation_p.C411R	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	629	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						CCCAATGTATTGCTTATTTGA	0.323													3	36					0	0	1	0	0	C	87454894	T	C	87454894	3	2	4	1	0	0	0	0	1	0	0	0	17474	1812	63	4	1947	4	WWP1	8	87454894	Missense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08		87454894	58909128	36	221										
PLEC	5339	broad.mit.edu	37	chr8	144999757	144999757	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tctcctcctcgatgcgcagcCggctgcgctcagccgcctct	10	19	3	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr8:144999757C>T	ENST00000322810.4	-	31	4920	c.4751G>A	c.(4750-4752)cGg>cAg	p.R1584Q	PLEC_ENST00000354589.3_Missense_Mutation_p.R1447Q|PLEC_ENST00000436759.2_Missense_Mutation_p.R1474Q|PLEC_ENST00000354958.2_Missense_Mutation_p.R1425Q|PLEC_ENST00000398774.2_Missense_Mutation_p.R1415Q|PLEC_ENST00000527096.1_Missense_Mutation_p.R1470Q|PLEC_ENST00000356346.3_Missense_Mutation_p.R1433Q|PLEC_ENST00000345136.3_Missense_Mutation_p.R1447Q|PLEC_ENST00000357649.2_Missense_Mutation_p.R1451Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1584	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GATGCGCAGCCGGCTGCGCTC	0.711													24	2					0	0	1	0	0	T	144999757	C	T	144999757	3	4	4	1	0	0	0	0	1	0	0	0	12099	652	23	1	9311	1	PLEC	8	144999757	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	57544863	144999757	1364265	37	222										
ELAVL2	1993	broad.mit.edu	37	chr9	23762158	23762158	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ccagagtcaactggtgacgaAcagttgttgtttatggtggt	13	6	1	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr9:23762158A>C	ENST00000397312.2	-	2	349	c.75T>G	c.(73-75)tgT>tgG	p.C25W	ELAVL2_ENST00000223951.6_Missense_Mutation_p.C25W|ELAVL2_ENST00000380117.1_Missense_Mutation_p.C25W|ELAVL2_ENST00000380110.4_Missense_Mutation_p.C54W|ELAVL2_ENST00000544538.1_Missense_Mutation_p.C25W	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	25					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CTGGTGACGAACAGTTGTTGT	0.438													8	180					0	0	1	0	0	C	23762158	A	C	23762158	3	2	4	1	0	0	0	0	1	0	0	0	5078	41	2	4	1028	4	ELAVL2	9	23762158	Missense_Mutation	SNP	A	TCGA-N5-A4RF-01A-11D-A28R-08		23762158	117451273	38	223										
HKDC1	80201	broad.mit.edu	37	chr10	71007270	71007270	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctctggcggccatcctgacaCgcctccgggagaacaagaag	12	14	1	3	rs139689016		TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr10:71007270C>T	ENST00000354624.5	+	9	1319	c.1186C>T	c.(1186-1188)Cgc>Tgc	p.R396C	HKDC1_ENST00000395086.2_Missense_Mutation_p.R396C|HKDC1_ENST00000488706.1_3'UTR	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	396					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CATCCTGACACGCCTCCGGGA	0.607													12	67					0	0	1	0	0	T	71007270	C	T	71007270	3	4	4	1	0	0	0	0	1	0	0	0	7233	536	19	1	1220	1	HKDC1	10	71007270	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		71007270	64527477	39	224										
PTEN	5728	broad.mit.edu	37	chr10	89720877	89720877	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cttttctccaaattttaaggTcagttaaattaaacattttg	4	6	2	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr10:89720877T>G	ENST00000371953.3	+	8	2383		c.e8+2		PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.N212fs*1(2)|p.Y27fs*1(2)|p.?(1)|p.G165_*404del(1)|p.D326_K342del(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AATTTTAAGGTCAGTTAAATT	0.323		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			7	30					0	0	1	0	0	G	89720877	T	G	89720877	5	3	4	1	0	0	0	0	0	0	1	0	12786	1681	58	4	1058	4	PTEN	10	89720877	Splice_Site	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08	18713607	89720877	45813870	40	225										
GPAM	57678	broad.mit.edu	37	chr10	113928673	113928673	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tggtgtttcatcgagccttcGtcgtatgaagaagcccccaa	10	11	1	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr10:113928673G>A	ENST00000348367.4	-	10	1029	c.832C>T	c.(832-834)Cga>Tga	p.R278*	GPAM_ENST00000369425.1_Nonsense_Mutation_p.R278*|GPAM_ENST00000423155.1_Nonsense_Mutation_p.R278*			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	278					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TCGAGCCTTCGTCGTATGAAG	0.378													32	16					0	0	1	0	0	A	113928673	G	A	113928673	4	1	4	1	0	0	0	0	0	1	0	0	6627	1153	40	1	1706	1	GPAM	10	113928673	Nonsense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	24207796	113928673	21606074	41	226										
SCGB1D2	10647	broad.mit.edu	37	chr11	62009833	62009833	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctggccctctgctgctaccaGggtgagtacatcagtcatga	11	12	3	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr11:62009833G>T	ENST00000244926.3	+	1	152	c.55_splice	c.e1+1	p.Q18_splice	RP11-703H8.9_ENST00000529875.1_RNA	NM_006551.3	NP_006542.1	O95969	SG1D2_HUMAN	secretoglobin, family 1D, member 2	18						extracellular space	binding			breast(1)|endometrium(1)|lung(1)	3						GCTGCTACCAGGGTGAGTACA	0.537													24	38					9.95505e-16	1.11378e-15	1	1	0	T	62009833	G	T	62009833	5	4	4	1	0	0	0	0	0	0	1	0	13949	1014	35	5	56	5	SCGB1D2	11	62009833	Splice_Site	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		62009833	72996683	42	227										
DHCR7	1717	broad.mit.edu	37	chr11	71146794	71146794	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ccttctggtggttggccaccCggaagatgtagtagcccacc	12	13	1	1	rs121909768	by1000genomes	TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr11:71146794C>A	ENST00000355527.3	-	9	1331	c.1055G>T	c.(1054-1056)cGg>cTg	p.R352L	DHCR7_ENST00000407721.2_Missense_Mutation_p.R352L	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	352			R -> Q (in SLOS).|R -> W (in SLOS).		cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	GTTGGCCACCCGGAAGATGTA	0.667									Smith-Lemli-Opitz syndrome				3	38					0.115264	0.115264	1	1	0	A	71146794	C	A	71146794	3	1	4	1	0	0	0	0	1	0	0	0	4505	652	23	5	376	5	DHCR7	11	71146794	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	9136961	71146794	63859722	43	228										
TTC12	54970	broad.mit.edu	37	chr11	113222820	113222820	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tcccaaggtaagcagctcctCggctctgtgccagtgcattg	11	13	1	0	rs147647661		TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr11:113222820C>T	ENST00000393020.1	+	16	1742	c.1337C>T	c.(1336-1338)tCg>tTg	p.S446L	TTC12_ENST00000314756.3_Missense_Mutation_p.S446L|TTC12_ENST00000478125.1_3'UTR|TTC12_ENST00000529221.1_Missense_Mutation_p.S446L|TTC12_ENST00000483239.2_Missense_Mutation_p.S452L			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	446							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		AGCAGCTCCTCGGCTCTGTGC	0.542													12	19					0	0	1	0	0	T	113222820	C	T	113222820	3	4	4	1	0	0	0	0	1	0	0	0	16740	893	31	1	1395	1	TTC12	11	113222820	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	42076026	113222820	21783696	44	229										
WNK1	65125	broad.mit.edu	37	chr12	971300	971300	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctctgtcttcacagaatctcGagtgagcagccaacagacag	9	12	4	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr12:971300G>A	ENST00000537687.1	+	8	2646	c.2003G>A	c.(2002-2004)cGa>cAa	p.R668Q	WNK1_ENST00000530271.2_Missense_Mutation_p.R668Q|WNK1_ENST00000315939.6_Missense_Mutation_p.R668Q|WNK1_ENST00000535572.1_Missense_Mutation_p.R668Q|WNK1_ENST00000340908.4_Missense_Mutation_p.R261Q	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	668					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAGAATCTCGAGTGAGCAGC	0.468													38	22					0	0	1	0	0	A	971300	G	A	971300	3	1	4	1	0	0	0	0	1	0	0	0	17436	1058	37	1	2033	1	WNK1	12	971300	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		971300	132880595	45	230										
CHD4	1108	broad.mit.edu	37	chr12	6700637	6700637	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctccttctctctcaccattgAagcggtcaatggcctcttgc	7	15	4	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr12:6700637A>G	ENST00000309577.6	-	22	3498	c.3335T>C	c.(3334-3336)tTc>tCc	p.F1112S	CHD4_ENST00000544040.1_Missense_Mutation_p.F1105S|CHD4_ENST00000357008.2_Missense_Mutation_p.F1112S|CHD4_ENST00000544484.1_Missense_Mutation_p.F1109S			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1112	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTCACCATTGAAGCGGTCAAT	0.428													47	17					0	0	1	0	0	G	6700637	A	G	6700637	3	3	4	1	0	0	0	0	1	0	0	0	3349	246	9	4	2479	4	CHD4	12	6700637	Missense_Mutation	SNP	A	TCGA-N5-A4RF-01A-11D-A28R-08	5729337	6700637	127151258	46	231										
EMG1	10436	broad.mit.edu	37	chr12	7080212	7080213	+	RNA	INS	-	-	C													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	acaagatcggaggccgtagtINSttattgtggtgctggaaggg					rs36063533		TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr12:7080212_7080213insC	ENST00000546220.1	+	0	157_158				U47924.28_ENST00000261406.6_lincRNA|U47924.19_ENST00000564245.1_RNA			Q92979	NEP1_HUMAN	EMG1 N1-specific pseudouridine methyltransferase						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										GAGGCCGTAGTTTATTGTGGTG	0.569													7	28	---	---	---	---						C	7080213	-	C	7080212	6	5	4	0	1	1	1	0	0	0	0	0	5118	1722	60	0		0	EMG1	12	7080212	RNA	INS	-	TCGA-N5-A4RF-01A-11D-A28R-08	379575	7080212	126771683	47	232										
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			11	1					4.36969e-10	4.74784e-10	1	1	0	A	25398284	C	A	25398284	3	1	4	1	0	0	0	0	1	0	0	0	8480	507	18	5	671	5	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	18318072	25398284	108453611	48	233										
DDX51	317781	broad.mit.edu	37	chr12	132625180	132625180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctcacctgtgggagttctctCgggagttagtgaagcagaga	14	8	2	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr12:132625180C>T	ENST00000397333.3	-	10	1579	c.1541G>A	c.(1540-1542)cGa>cAa	p.R514Q		NM_175066.3	NP_778236.2	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	514	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			endometrium(1)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		GGAGTTCTCTCGGGAGTTAGT	0.642													14	60					0	0	1	0	0	T	132625180	C	T	132625180	3	4	4	1	0	0	0	0	1	0	0	0	4392	884	31	1	483	1	DDX51	12	132625180	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	107226896	132625180	1226715	49	234										
RB1	5925	broad.mit.edu	37	chr13	49037935	49037943	+	In_Frame_Del	DEL	AACAGCATA	AACAGCATA	-													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cttaaattcaaaatcattgtAacagcatacaaggatcttcc							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr13:49037935_49037943delAACAGCATA	ENST00000267163.4	+	21	2313_2321	c.2175_2183delAACAGCATA	c.(2173-2184)gtc>gt	p.VTAY725del		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	725	Domain B.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(10)|p.I703_E737del(2)|p.Y728C(1)|p.C712_A727del(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAATCATTGTAACAGCATACAAGGATCTT	0.301		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			28	3	---	---	---	---						-	49037943	AACAGCATA	-	49037935	7	5	4	1	0	1	0	1	0	0	0	0	13149	349	13	0	2257	0	RB1	13	49037935	In_Frame_Del	DEL	AACAGCATA	TCGA-N5-A4RF-01A-11D-A28R-08		49037935	66131943	50	235										
HSPA2	3306	broad.mit.edu	37	chr14	65008092	65008092	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aatgtgctgcgcatcatcaaCgagcccacggcggcggccat	12	14	2	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr14:65008092C>T	ENST00000247207.6	+	1	907	c.525C>T	c.(523-525)aaC>aaT	p.N175N	HSPA2_ENST00000554883.1_3'UTR|HSPA2_ENST00000394709.1_Silent_p.N175N	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	175					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GCATCATCAACGAGCCCACGG	0.652													49	83					0	0	1	0	0	T	65008092	C	T	65008092	2	4	4	1	0	0	0	0	0	0	0	1	7453	535	19	1		1	HSPA2	14	65008092	Silent	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		65008092	42341448	51	236										
ZNF839	55778	broad.mit.edu	37	chr14	102807718	102807718	+	Frame_Shift_Del	DEL	G	G	-													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tctgaagaaagccatacaacGacggtttctggtggcaatgg							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr14:102807718delG	ENST00000262236.5	+	8	1999	c.1644delG	c.(1642-1644)acfs	p.T549fs	ZNF839_ENST00000420933.2_3'UTR|ZNF839_ENST00000558850.1_Frame_Shift_Del_p.T547fs|ZNF839_ENST00000442396.2_Frame_Shift_Del_p.T663fs|ZNF839_ENST00000559185.1_Frame_Shift_Del_p.T547fs	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	547						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GCCATACAACGACGGTTTCTG	0.527													22	51	---	---	---	---						-	102807718	G	-	102807718	7	5	4	1	0	1	0	1	0	0	0	0	18234	1045	37	0	2016	0	ZNF839	14	102807718	Frame_Shift_Del	DEL	G	TCGA-N5-A4RF-01A-11D-A28R-08	37799626	102807718	4541822	52	237										
SV2B	9899	broad.mit.edu	37	chr15	91795210	91795210	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	atggagccttcctcttctgcCgactcatctcaggcatcggg	10	14	4	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr15:91795210C>T	ENST00000394232.1	+	3	1083	c.613C>T	c.(613-615)Cga>Tga	p.R205*	SV2B_ENST00000330276.4_Nonsense_Mutation_p.R205*|SV2B_ENST00000545111.2_Nonsense_Mutation_p.R54*	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	205					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CCTCTTCTGCCGACTCATCTC	0.557													19	13					0	0	1	0	0	T	91795210	C	T	91795210	4	4	4	1	0	0	0	0	0	1	0	0	15473	644	23	1	619	1	SV2B	15	91795210	Nonsense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		91795210	10736182	53	238										
ADCY9	115	broad.mit.edu	37	chr16	4165230	4165230	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cttcttctgcctgcgcagccGgcctccgccgcccactcgcc	9	22	2	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr16:4165230G>A	ENST00000294016.3	-	2	752	c.214C>T	c.(214-216)Cgg>Tgg	p.R72W		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	72					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTGCGCAGCCGGCCTCCGCCG	0.677													7	19					0	0	1	0	0	A	4165230	G	A	4165230	3	1	4	1	0	0	0	0	1	0	0	0	300	1115	39	1	3887	1	ADCY9	16	4165230	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		4165230	86189523	54	239										
CTCF	10664	broad.mit.edu	37	chr16	67645112	67645115	+	Frame_Shift_Del	DEL	TTGC	TTGC	-													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgttcctgtgactgtacctgTtgctaccacttcagtagaag							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr16:67645112_67645115delTTGC	ENST00000264010.4	+	3	821_824	c.377_380delTTGC	c.(376-381)gtfs	p.VA126fs	CTCF_ENST00000401394.1_Intron	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	126					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		ACTGTACCTGTTGCTACCACTTCA	0.436													38	48	---	---	---	---						-	67645115	TTGC	-	67645112	7	5	4	1	0	1	0	1	0	0	0	0	4024	1725	60	0	379	0	CTCF	16	67645112	Frame_Shift_Del	DEL	TTGC	TCGA-N5-A4RF-01A-11D-A28R-08	63479882	67645112	22709641	55	240										
NOB1	28987	broad.mit.edu	37	chr16	69778900	69778900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cacagtgtgagcagaacactCggctcatgtcagacgttgtc	11	11	2	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr16:69778900C>T	ENST00000268802.5	-	8	874	c.845G>A	c.(844-846)cGa>cAa	p.R282Q		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	282						nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GCAGAACACTCGGCTCATGTC	0.577													8	27					0	0	1	0	0	T	69778900	C	T	69778900	3	4	4	1	0	0	0	0	1	0	0	0	10557	884	31	1	401	1	NOB1	16	69778900	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	2133788	69778900	20575853	56	241										
GAS8	2622	broad.mit.edu	37	chr16	90094129	90094129	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	agaggacatgagcaaggagcAggtgagcagagcgggctgtg	19	6	0	4			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr16:90094129A>G	ENST00000268699.4	+	2	211	c.90_splice	c.e2+1	p.Q30_splice	GAS8_ENST00000536122.1_Splice_Site_p.Q5_splice|GAS8_ENST00000540721.1_Intron	NM_001481.2	NP_001472.1	O95995	GAS8_HUMAN	growth arrest-specific 8	30	Regulates microtubule-binding (By similarity).				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			endometrium(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		AGCAAGGAGCAGGTGAGCAGA	0.612													29	28					0	0	1	0	0	G	90094129	A	G	90094129	5	3	4	1	0	0	0	0	0	0	1	0	6290	202	7	4	95	4	GAS8	16	90094129	Splice_Site	SNP	A	TCGA-N5-A4RF-01A-11D-A28R-08	20315229	90094129	260624	57	242										
TSR1	55720	broad.mit.edu	37	chr17	2228662	2228662	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gtgattggcgcatagactgtCgccaccagggccatgtcagc	13	12	1	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr17:2228662C>T	ENST00000301364.4	-	12	3035	c.1956G>A	c.(1954-1956)gcG>gcA	p.A652A		NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	652					ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						CATAGACTGTCGCCACCAGGG	0.453													7	33					0	0	1	0	0	T	2228662	C	T	2228662	2	4	4	1	0	0	0	0	0	0	0	1	16724	871	31	1		1	TSR1	17	2228662	Silent	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		2228662	78966548	58	243										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			42	8					0	0	1	0	0	T	7577538	C	T	7577538	3	4	4	1	0	0	0	0	1	0	0	0	16441	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	5348876	7577538	73617672	59	244										
HOXB9	3219	broad.mit.edu	37	chr17	46700472	46700472	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tttttccgggaagagcgagcGtgcagccagttggcggaggg	18	8	0	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr17:46700472G>A	ENST00000550387.1	-	2	507	c.304C>T	c.(304-306)Cgc>Tgc	p.R102C	HOXB9_ENST00000311177.5_Silent_p.H181H|HOXB7_ENST00000567101.1_Intron			P17482	HXB9_HUMAN	homeobox B9	0					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|liver(1)|lung(6)|prostate(1)	12						AAGAGCGAGCGTGCAGCCAGT	0.547													24	105					0	0	1	0	0	A	46700472	G	A	46700472	3	1	4	1	0	0	0	0	1	0	0	0	7348	1136	40	1	213	1	HOXB9	17	46700472	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	39122934	46700472	34494738	60	245										
PDK2	5164	broad.mit.edu	37	chr17	48184459	48184459	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gatgcctacgacatggctaaGctcctgtgtgacaagtatta	10	9	0	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr17:48184459G>C	ENST00000503176.1	+	6	788	c.627G>C	c.(625-627)aaG>aaC	p.K209N	PDK2_ENST00000007708.3_Missense_Mutation_p.K145N	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	209	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						ACATGGCTAAGCTCCTGTGTG	0.562									Autosomal Dominant Polycystic Kidney Disease				13	81					0	0	1	0	0	C	48184459	G	C	48184459	3	2	4	1	0	0	0	0	1	0	0	0	11722	962	34	5	649	5	PDK2	17	48184459	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	1483987	48184459	33010751	61	246										
HLF	3131	broad.mit.edu	37	chr17	53392710	53392710	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ccagcatccctggccaggaaAtgtttgaccctcgcaaacgc	9	15	0	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr17:53392710A>C	ENST00000226067.5	+	3	1047	c.574A>C	c.(574-576)Atg>Ctg	p.M192L	HLF_ENST00000573945.1_Missense_Mutation_p.M107L|HLF_ENST00000575345.1_Missense_Mutation_p.M107L|HLF_ENST00000430986.2_Missense_Mutation_p.M107L	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	192	Pro-rich (proline/acidic region (PAR)).				multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						TGGCCAGGAAATGTTTGACCC	0.517			T	TCF3	ALL								49	23					0	0	1	0	0	C	53392710	A	C	53392710	3	2	4	1	0	0	0	0	1	0	0	0	7254	101	4	4	584	4	HLF	17	53392710	Missense_Mutation	SNP	A	TCGA-N5-A4RF-01A-11D-A28R-08	5208251	53392710	27802500	62	247										
NPLOC4	55666	broad.mit.edu	37	chr17	79563195	79563195	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aatgtccgtctggagagagcCggcacatgttgggatgcttg	15	8	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr17:79563195C>T	ENST00000374747.5	-	11	1196	c.1067G>A	c.(1066-1068)cGg>cAg	p.R356Q	NPLOC4_ENST00000539314.1_Missense_Mutation_p.R195Q|NPLOC4_ENST00000331134.6_Missense_Mutation_p.R356Q			Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	356					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TGGAGAGAGCCGGCACATGTT	0.443													57	20					0	0	1	0	0	T	79563195	C	T	79563195	3	4	4	1	0	0	0	0	1	0	0	0	10633	652	23	1	787	1	NPLOC4	17	79563195	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	26170485	79563195	1632015	63	248										
SERPINB4	6318	broad.mit.edu	37	chr18	61310414	61310414	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	catgatatgttgcagcttttTctgtggtgttctctgtgact	10	7	2	2	rs149334777		TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr18:61310414T>C	ENST00000341074.5	-	3	318	c.203A>G	c.(202-204)gAa>gGa	p.E68G	SERPINB4_ENST00000356424.6_Missense_Mutation_p.E68G	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGCAGCTTTTTCTGTGGTGTT	0.403													21	31					0	0	1	0	0	C	61310414	T	C	61310414	3	2	4	1	0	0	0	0	1	0	0	0	14156	1783	62	4	993	4	SERPINB4	18	61310414	Missense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08		61310414	16766834	64	249										
ZNF700	90592	broad.mit.edu	37	chr19	12060050	12060050	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	agccttcaatctttccagttCctttcgatatcatgaaagga	6	10	3	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:12060050C>A	ENST00000482090.1	+	3	1575	c.1157C>A	c.(1156-1158)tCc>tAc	p.S386Y	CTD-2006C1.12_ENST00000586394.1_RNA|ZNF700_ENST00000254321.5_Missense_Mutation_p.S404Y|ZNF763_ENST00000590798.1_Intron|ZNF763_ENST00000591944.1_Intron|ZNF763_ENST00000538752.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						CTTTCCAGTTCCTTTCGATAT	0.423													11	52					3.86212e-05	3.96745e-05	1	1	0	A	12060050	C	A	12060050	3	1	4	1	0	0	0	0	1	0	0	0	18159	855	30	2	1225	2	ZNF700	19	12060050	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08		12060050	47068933	65	250										
SLC1A6	6511	broad.mit.edu	37	chr19	15067364	15067364	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gaaggggttccggtgagtgaCgaggaagtagatgaggggaa	20	3	0	4			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:15067364C>T	ENST00000430939.2	-	6	1030	c.901G>A	c.(901-903)Gtc>Atc	p.V301I	SLC1A6_ENST00000221742.3_Missense_Mutation_p.V365I|SLC1A6_ENST00000600144.1_Intron			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	365					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	CGGTGAGTGACGAGGAAGTAG	0.617													19	27					0	0	1	0	0	T	15067364	C	T	15067364	3	4	4	1	0	0	0	0	1	0	0	0	14490	536	19	1	617	1	SLC1A6	19	15067364	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	3007314	15067364	44061619	66	251										
ZNF493	284443	broad.mit.edu	37	chr19	21606597	21606597	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tggagagaaaccctacaaatGtgaagaatgtggcaaagcct	11	7	0	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:21606597G>A	ENST00000392288.2	+	4	1245	c.1136G>A	c.(1135-1137)tGt>tAt	p.C379Y	ZNF493_ENST00000355504.4_Missense_Mutation_p.C251Y|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CCCTACAAATGTGAAGAATGT	0.368													6	44					0	0	1	0	0	A	21606597	G	A	21606597	3	1	4	1	0	0	0	0	1	0	0	0	18000	1377	48	3	1213	3	ZNF493	19	21606597	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	6539233	21606597	37522386	67	252										
ZNF676	163223	broad.mit.edu	37	chr19	22364200	22364200	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aaatactttgctctgtgtagTtgttaaactctggttaagtt	8	5	2	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:22364200T>A	ENST00000397121.2	-	3	636	c.319A>T	c.(319-321)Act>Tct	p.T107S		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CTCTGTGTAGTTGTTAAACTC	0.333													27	40					0	0	1	0	0	A	22364200	T	A	22364200	3	1	4	1	0	0	0	0	1	0	0	0	18139	1725	60	4	1451	4	ZNF676	19	22364200	Missense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08	757603	22364200	36764783	68	253										
FXYD5	53827	broad.mit.edu	37	chr19	35657174	35657174	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	atgaacacaccctccggaaaCgggggctgttggtcgcagct	13	12	0	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:35657174C>T	ENST00000342879.3	+	7	1211	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W	FXYD5_ENST00000541435.2_Missense_Mutation_p.R145W|FXYD5_ENST00000590686.1_Missense_Mutation_p.R145W|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000392217.3_Missense_Mutation_p.R74W|FXYD5_ENST00000588699.1_Missense_Mutation_p.R145W|FXYD5_ENST00000543307.1_Missense_Mutation_p.R145W|FXYD5_ENST00000392219.2_Missense_Mutation_p.R145W|FXYD5_ENST00000423817.3_Missense_Mutation_p.R145W			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	145					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CCTCCGGAAACGGGGGCTGTT	0.552													55	105					0	0	1	0	0	T	35657174	C	T	35657174	3	4	4	1	0	0	0	0	1	0	0	0	6155	527	19	1	459	1	FXYD5	19	35657174	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	13292974	35657174	23471809	69	254										
RSPH6A	81492	broad.mit.edu	37	chr19	46314094	46314094	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cagcagattcaccaggtgctCgtacctgcctcccgcaggag	11	15	1	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:46314094C>T	ENST00000221538.3	-	2	797	c.655G>A	c.(655-657)Gag>Aag	p.E219K	RSPH6A_ENST00000597055.1_Missense_Mutation_p.E219K|RSPH6A_ENST00000600188.1_5'UTR	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	219						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						ACCAGGTGCTCGTACCTGCCT	0.627													7	14					0	0	1	0	0	T	46314094	C	T	46314094	3	4	4	1	0	0	0	0	1	0	0	0	13758	893	31	1	1518	1	RSPH6A	19	46314094	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	10656920	46314094	12814889	70	255										
PPP2R1A	5518	broad.mit.edu	37	chr19	52716323	52716323	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ccaggccgctgaagacaagtCctggcgcgtccgctacatgg	13	14	0	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:52716323C>A	ENST00000322088.6	+	6	825	c.767C>A	c.(766-768)tCc>tAc	p.S256Y	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S201Y|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.S77Y	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	256	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.S256F(11)|p.S256Y(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GAAGACAAGTCCTGGCGCGTC	0.617			Mis		clear cell ovarian carcinoma								14	36					1.5842e-08	1.68882e-08	1	1	0	A	52716323	C	A	52716323	3	1	4	1	0	0	0	0	1	0	0	0	12430	855	30	2	789	2	PPP2R1A	19	52716323	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	6402229	52716323	6412660	71	256										
ZNF444	55311	broad.mit.edu	37	chr19	56658404	56658404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gggaggcgctggggctgctcCgcgccctgtgccgggactgg	20	13	0	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr19:56658404C>T	ENST00000337080.3	+	3	491	c.124C>T	c.(124-126)Cgc>Tgc	p.R42C	ZNF444_ENST00000592949.1_Missense_Mutation_p.R42C	NM_001253792.1|NM_018337.3	NP_001240721.1|NP_060807.2	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	42	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|lung(5)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		GGGGCTGCTCCGCGCCCTGTG	0.746													12	10					0	0	1	0	0	T	56658404	C	T	56658404	3	4	4	1	0	0	0	0	1	0	0	0	17973	652	23	1	126	1	ZNF444	19	56658404	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	3942081	56658404	2470579	72	257										
ESF1	51575	broad.mit.edu	37	chr20	13763375	13763375	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	acatgaggttttcattttttTaattcctatagaattatcta	4	5	2	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr20:13763375T>A	ENST00000202816.1	-	2	519	c.412A>T	c.(412-414)Aaa>Taa	p.K138*		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	138	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTCATTTTTTTAATTCCTATA	0.259													7	21					0	0	1	0	0	A	13763375	T	A	13763375	4	1	4	1	0	0	0	0	0	1	0	0	5279	1763	61	4	2195	4	ESF1	20	13763375	Nonsense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08		13763375	49262145	73	258										
KRTAP24-1	643803	broad.mit.edu	37	chr21	31654815	31654815	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aaagcagttggaaccgttgcGgagggtttggcaggctttgg	17	6	0	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr21:31654815G>A	ENST00000340345.4	-	1	461	c.436C>T	c.(436-438)Cgc>Tgc	p.R146C		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	146						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						GAACCGTTGCGGAGGGTTTGG	0.498													27	65					0	0	1	0	0	A	31654815	G	A	31654815	3	1	4	1	0	0	0	0	1	0	0	0	8585	1116	39	1	332	1	KRTAP24-1	21	31654815	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		31654815	16475080	74	259										
DSCR3	10311	broad.mit.edu	37	chr21	38600596	38600596	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cgagctctccaccaccagctCtcccgttagtggctgcgtga	10	16	2	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr21:38600596C>T	ENST00000288304.5	-	7	1250	c.458G>A	c.(457-459)aGa>aAa	p.R153K	DSCR3_ENST00000476950.1_Missense_Mutation_p.E169K|AP001432.14_ENST00000440629.1_lincRNA|DSCR3_ENST00000398998.1_Missense_Mutation_p.E148K|DSCR3_ENST00000399000.3_5'UTR|DSCR3_ENST00000399001.1_Missense_Mutation_p.E71K|DSCR3_ENST00000309117.6_Missense_Mutation_p.E196K|DSCR3_ENST00000539844.1_Missense_Mutation_p.E119K			O14972	DSCR3_HUMAN	Down syndrome critical region gene 3	188					vacuolar transport	nucleus|retromer complex				endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9						ACCACCAGCTCTCCCGTTAGT	0.557													25	47					0	0	1	0	0	T	38600596	C	T	38600596	3	4	4	1	0	0	0	0	1	0	0	0	4797	922	32	3	319	3	DSCR3	21	38600596	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	6945781	38600596	9529299	75	260										
TBX1	6899	broad.mit.edu	37	chr22	19750852	19750852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tggacttcgtgccggtggacGataagcgctaccggtgagcg	16	10	0	1			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr22:19750852G>A	ENST00000332710.4	+	4	628	c.499G>A	c.(499-501)Gat>Aat	p.D167N	TBX1_ENST00000359500.3_Missense_Mutation_p.D167N|TBX1_ENST00000329705.7_Missense_Mutation_p.D167N	NM_080647.1	NP_542378.1	O43435	TBX1_HUMAN	T-box 1	167					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|lung(3)|ovary(2)	8	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				GCCGGTGGACGATAAGCGCTA	0.612													31	35					0	0	1	0	0	A	19750852	G	A	19750852	3	1	4	1	0	0	0	0	1	0	0	0	15709	1058	37	1	509	1	TBX1	22	19750852	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		19750852	31553714	76	261										
EP300	2033	broad.mit.edu	37	chr22	41489056	41489057	+	Frame_Shift_Ins	INS	-	-	A													0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	cgccttcagccaagcggcctINSaaactctcatctccggccct							TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chr22:41489056_41489057insA	ENST00000263253.7	+	1	1267_1268	c.48_49insA	c.(46-51)ccaactfs	p.T17fs		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	17	Interaction with ALX1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.K17E(1)		NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CCAAGCGGCCTAAACTCTCATC	0.55			"T,  N, F, Mis, O"	"MLL, RUNXBP2"	"colorectal, breast, pancreatic, AML, ALL, DLBCL"				Rubinstein-Taybi syndrome				72	114	---	---	---	---						A	41489057	-	A	41489056	7	5	4	1	0	1	1	0	0	0	0	0	5176	1509	53	0	50	0	EP300	22	41489056	Frame_Shift_Ins	INS	-	TCGA-N5-A4RF-01A-11D-A28R-08	21738204	41489056	9815510	77	262										
RBBP7	5931	broad.mit.edu	37	chrX	16870879	16870879	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aaaacttcgaaaccttatccGcagagccggtggctagaata	9	10	0	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:16870879G>A	ENST00000380087.2	-	7	1238	c.878C>T	c.(877-879)gCg>gTg	p.A293V	RBBP7_ENST00000404022.1_Missense_Mutation_p.A284V|RBBP7_ENST00000380084.4_Missense_Mutation_p.A337V			Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	293					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			biliary_tract(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	25	Hepatocellular(33;0.0997)					AACCTTATCCGCAGAGCCGGT	0.428													145	93					0	0	1	0	0	A	16870879	G	A	16870879	3	1	4	1	0	0	0	0	1	0	0	0	13155	1087	38	1	423	1	RBBP7	23	16870879	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08		16870879	138399681	78	263										
PDK3	5165	broad.mit.edu	37	chrX	24549846	24549846	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	aaggagatctgaaactgtatTccatggaaggagtgggtact	13	5	1	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:24549846T>A	ENST00000441463.2	+	10	1036	c.1036T>A	c.(1036-1038)Tcc>Acc	p.S346T	PDK3_ENST00000379162.4_Missense_Mutation_p.S346T	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	346	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						GAAACTGTATTCCATGGAAGG	0.358													78	118					0	0	1	0	0	A	24549846	T	A	24549846	3	1	4	1	0	0	0	0	1	0	0	0	11723	1783	62	4	1074	4	PDK3	23	24549846	Missense_Mutation	SNP	T	TCGA-N5-A4RF-01A-11D-A28R-08	7678967	24549846	130720714	79	264										
DMD	1756	broad.mit.edu	37	chrX	32305742	32305742	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ccctttccacaggcgttgcaCtttgcaatgctgctgtcttc	8	14	1	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:32305742C>A	ENST00000357033.4	-	43	6400	c.6194G>T	c.(6193-6195)aGt>aTt	p.S2065I	DMD_ENST00000378677.2_Missense_Mutation_p.S2061I	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2065					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGGCGTTGCACTTTGCAATGC	0.388													23	54					1.10923e-09	1.19374e-09	1	1	0	A	32305742	C	A	32305742	3	1	4	1	0	0	0	0	1	0	0	0	4608	565	20	5	5159	5	DMD	23	32305742	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	7755896	32305742	122964818	80	265										
DLG3	1741	broad.mit.edu	37	chrX	69699084	69699084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ctctgggtctgggtccctccGaacaagtgaaaagaggtcct	12	11	2	2			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:69699084G>A	ENST00000194900.4	+	11	1885	c.1544G>A	c.(1543-1545)cGa>cAa	p.R515Q	DLG3_ENST00000374360.3_Missense_Mutation_p.R497Q|DLG3_ENST00000542398.1_Missense_Mutation_p.R14Q|DLG3_ENST00000374355.3_Missense_Mutation_p.R160Q			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	497	SH3.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GGGTCCCTCCGAACAAGTGAA	0.498													61	96					0	0	1	0	0	A	69699084	G	A	69699084	3	1	4	1	0	0	0	0	1	0	0	0	4584	1058	37	1	1666	1	DLG3	23	69699084	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	37393342	69699084	85571476	81	266										
IRS4	8471	broad.mit.edu	37	chrX	107976125	107976125	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gagtcaaatccagcagctgcGgctgctgcgccgatgcccgg	14	14	1	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:107976125G>A	ENST00000372129.2	-	1	3526	c.3450C>T	c.(3448-3450)gcC>gcT	p.A1150A		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	1150	Ala-rich.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CAGCAGCTGCGGCTGCTGCGC	0.657													25	164					0	0	1	0	0	A	107976125	G	A	107976125	2	1	4	1	0	0	0	0	0	0	0	1	7885	1103	39	1		1	IRS4	23	107976125	Silent	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	38277041	107976125	47294435	82	267										
CT45A5	441521	broad.mit.edu	37	chrX	134948067	134948067	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	ggtgcattgctaccaggtttCtgcatcatcccatctttgct	8	12	3	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:134948067C>A	ENST00000370724.3	-	3	502	c.258G>T	c.(256-258)caG>caT	p.Q86H	CT45A4_ENST00000420087.2_Intron|CT45A5_ENST00000491480.1_Missense_Mutation_p.Q86H	NM_001007551.3|NM_001172288.1	NP_001007552.1|NP_001165759.1	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	86										endometrium(1)|large_intestine(2)|lung(6)	9						TACCAGGTTTCTGCATCATCC	0.468													171	198					4.61621e-74	5.43366e-74	1	1	0	A	134948067	C	A	134948067	3	1	4	1	0	0	0	0	1	0	0	0	4014	912	32	2	323	2	CT45A5	23	134948067	Missense_Mutation	SNP	C	TCGA-N5-A4RF-01A-11D-A28R-08	26971942	134948067	20322493	83	268										
MCF2	4168	broad.mit.edu	37	chrX	138724667	138724667	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tcttgcctctccggggatttGcttctgccatttcgcctgta	9	13	3	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:138724667G>C	ENST00000370576.4	-	1	220	c.11C>G	c.(10-12)gCa>gGa	p.A4G	MCF2_ENST00000370578.4_Intron|MCF2_ENST00000338585.6_Missense_Mutation_p.A4G|MCF2_ENST00000414978.1_Intron|MCF2_ENST00000370573.4_Missense_Mutation_p.A4G|MCF2_ENST00000536274.1_Missense_Mutation_p.A4G|MCF2_ENST00000519895.1_Intron|MCF2_ENST00000520602.1_Intron	NM_001171879.1|NM_005369.4	NP_001165350.1|NP_005360.3	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	4	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					CCGGGGATTTGCTTCTGCCAT	0.473													93	117					0	0	1	0	0	C	138724667	G	C	138724667	3	2	4	1	0	0	0	0	1	0	0	0	9427	1319	46	5	2946	5	MCF2	23	138724667	Missense_Mutation	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	3776600	138724667	16545893	84	269										
FLNA	0	broad.mit.edu	37	chrX	153581770	153581770	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	tccgtctctgagatgttgatGgggatgtcggcagcagagcc	15	9	1	3			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:153581770G>T	ENST00000422373.1	-	36	6140	c.5892C>A	c.(5890-5892)ccC>ccA	p.P1964P	FLNA_ENST00000360319.4_Silent_p.P1964P|FLNA_ENST00000369856.3_Silent_p.P105P|FLNA_ENST00000369850.3_Silent_p.P1972P|FLNA_ENST00000344736.4_Silent_p.P1932P	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1972					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGATGTTGATGGGGATGTCGG	0.637													40	85					1.04594e-18	1.18191e-18	1	1	0	T	153581770	G	T	153581770	2	4	4	1	0	0	0	0	0	0	0	1	5965	1335	47	5		5	FLNA	23	153581770	Silent	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	14857103	153581770	1688790	85	270										
RAB39B	116442	broad.mit.edu	37	chrX	154490295	154490295	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0232558139534884	2	1	0.347959183673469	1.44982993197279	0.197704081632653	1	1	0	gtttcaatgtacttcatgccGtatgcagcagccagtttctc	8	11	3	0			TCGA-N5-A4RF-01A-11D-A28R-08	TCGA-N5-A4RF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3e50113-790a-4113-b65b-3712ac8d076d	39ed2a4e-81b1-4c89-bda1-be827d62cdf6	g.chrX:154490295G>A	ENST00000369454.3	-	2	735	c.435C>T	c.(433-435)taC>taT	p.Y145Y		NM_171998.2	NP_741995.1	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	145					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding			breast(1)|central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(12)	19	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACTTCATGCCGTATGCAGCAG	0.498													52	64					0	0	1	0	0	A	154490295	G	A	154490295	2	1	4	1	0	0	0	0	0	0	0	1	12981	1140	40	1		1	RAB39B	23	154490295	Silent	SNP	G	TCGA-N5-A4RF-01A-11D-A28R-08	908525	154490295	780265	86	271										
MMEL1	79258	broad.mit.edu	37	chr1	2540796	2540796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	actctggttcatgcaggagcGgtacagcgtcctggccttct	12	12	3	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr1:2540796G>A	ENST00000288709.6	-	6	730	c.490C>T	c.(490-492)Cgc>Tgc	p.R164C	MMEL1_ENST00000378412.3_Missense_Mutation_p.R173C|MMEL1_ENST00000502556.1_Intron	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	173					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		ATGCAGGAGCGGTACAGCGTC	0.687													9	12					0	0	1	0	0	A	2540796	G	A	2540796	3	1	5	1	0	0	0	0	1	0	0	0	9693	1116	39	1	1898	1	MMEL1	1	2540796	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		2540796	246709825	1	272										
ABCA4	24	broad.mit.edu	37	chr1	94528265	94528265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	caaacccgccccagatgtacCggaaatcttccacgggatca	8	15	2	1	rs61749410		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr1:94528265C>T	ENST00000370225.3	-	13	1891	c.1805G>A	c.(1804-1806)cGg>cAg	p.R602Q	ABCA4_ENST00000535735.1_Missense_Mutation_p.R602Q	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	602			R -> Q (in STGD1).|R -> W (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCAGATGTACCGGAAATCTTC	0.557													23	24					0	0	1	0	0	T	94528265	C	T	94528265	3	4	5	1	0	0	0	0	1	0	0	0	34	652	23	1	5168	1	ABCA4	1	94528265	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	91987469	94528265	154722356	2	273										
HSPA6	3310	broad.mit.edu	37	chr1	161495873	161495873	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gccccacgtggagtcccccaGatagaggtgacttttgacat	11	12	0	4			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr1:161495873G>C	ENST00000309758.4	+	1	1838	c.1425G>C	c.(1423-1425)caG>caC	p.Q475H		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	475					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GAGTCCCCCAGATAGAGGTGA	0.537													16	50					0	0	1	0	0	C	161495873	G	C	161495873	3	2	5	1	0	0	0	0	1	0	0	0	7457	933	33	2	1427	2	HSPA6	1	161495873	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	66967608	161495873	87754748	3	274										
DDR2	4921	broad.mit.edu	37	chr1	162746131	162746131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gccgggcagtgctccctatcCgctggatgtcttgggagagt	15	11	1	1	rs121964863		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr1:162746131C>T	ENST00000367922.2	+	17	2692	c.2254C>T	c.(2254-2256)Cgc>Tgc	p.R752C	DDR2_ENST00000367921.3_Missense_Mutation_p.R752C	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	752	Protein kinase.		R -> C (in SEMD-SL; causes retention in an intracellular compartment and thereby abolishes signaling in response collagen binding).		cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GCTCCCTATCCGCTGGATGTC	0.502													7	111					0	0	1	0	0	T	162746131	C	T	162746131	3	4	5	1	0	0	0	0	1	0	0	0	4360	652	23	1	2308	1	DDR2	1	162746131	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	1250258	162746131	86504490	4	275										
POU2F1	5451	broad.mit.edu	37	chr1	167381351	167381351	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gtgagaccagcacaacacagAccacctccactcctttgtcc	6	17	0	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr1:167381351A>C	ENST00000367862.5	+	14	1913	c.1678A>C	c.(1678-1680)Acc>Ccc	p.T560P	POU2F1_ENST00000367866.2_Missense_Mutation_p.T571P|POU2F1_ENST00000541643.3_Missense_Mutation_p.T548P|POU2F1_ENST00000367865.1_3'UTR|POU2F1_ENST00000429375.2_Missense_Mutation_p.T508P|POU2F1_ENST00000420254.3_Missense_Mutation_p.T548P	NM_001198783.1	NP_001185712.1	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	548					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	30						CACAACACAGACCACCTCCAC	0.602													16	59					0	0	1	0	0	C	167381351	A	C	167381351	3	2	5	1	0	0	0	0	1	0	0	0	12316	275	10	4	1692	4	POU2F1	1	167381351	Missense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08	4635220	167381351	81869270	5	276										
EXO1	9156	broad.mit.edu	37	chr1	242042601	242042601	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tctcactgcagagttcaaatGcatcaaagctttctcagtgc	7	11	4	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr1:242042601G>C	ENST00000366548.3	+	13	2658	c.2065G>C	c.(2065-2067)Gca>Cca	p.A689P	EXO1_ENST00000348581.5_Missense_Mutation_p.A689P|EXO1_ENST00000518483.1_Missense_Mutation_p.A689P	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	689	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GAGTTCAAATGCATCAAAGCT	0.413								Editing and processing nucleases					17	22					0	0	1	0	0	C	242042601	G	C	242042601	3	2	5	1	0	0	0	0	1	0	0	0	5327	1319	46	5	2103	5	EXO1	1	242042601	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	74661250	242042601	7208020	6	277										
TTC27	55622	broad.mit.edu	37	chr2	32983377	32983377	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aggcagaagaaatccttagaCaagagctggagaaaaaagaa	11	5	0	6			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr2:32983377C>T	ENST00000317907.4	+	13	1702	c.1471C>T	c.(1471-1473)Caa>Taa	p.Q491*		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	491							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						AATCCTTAGACAAGAGCTGGA	0.383													4	87					0	0	1	0	0	T	32983377	C	T	32983377	4	4	5	1	0	0	0	0	0	1	0	0	16756	479	17	3	1521	3	TTC27	2	32983377	Nonsense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		32983377	210215996	7	278										
TBC1D8	11138	broad.mit.edu	37	chr2	101648744	101648744	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gtttaccgatcactcggtggTtgaagtaatcgggcagcatc	12	9	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr2:101648744T>C	ENST00000409318.1	-	11	2052	c.1922A>G	c.(1921-1923)aAc>aGc	p.N641S	TBC1D8_ENST00000376840.4_Missense_Mutation_p.N626S	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	626	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						CACTCGGTGGTTGAAGTAATC	0.532													28	44					0	0	1	0	0	C	101648744	T	C	101648744	3	2	5	1	0	0	0	0	1	0	0	0	15684	1725	60	4	1585	4	TBC1D8	2	101648744	Missense_Mutation	SNP	T	TCGA-N5-A4RJ-01A-11D-A28R-08	68665367	101648744	141550629	8	279										
MERTK	10461	broad.mit.edu	37	chr2	112686937	112686937	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tgccttcaaacacacagttgGacacataatactttctgaac	5	11	2	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr2:112686937G>T	ENST00000295408.4	+	2	559	c.302G>T	c.(301-303)gGa>gTa	p.G101V	MERTK_ENST00000409780.1_Intron|MERTK_ENST00000421804.2_Missense_Mutation_p.G101V			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	101	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.G101V(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CACACAGTTGGACACATAATA	0.448													26	51					1.26454e-06	1.38356e-06	1	1	0	T	112686937	G	T	112686937	3	4	5	1	0	0	0	0	1	0	0	0	9528	1174	41	2	308	2	MERTK	2	112686937	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	11038193	112686937	130512436	9	280										
SAP130	79595	broad.mit.edu	37	chr2	128757879	128757879	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ggttctccacttttggttttAcctgagccattgtatgaagc	9	9	1	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr2:128757879A>C	ENST00000357702.5	-	8	1227		c.e8+1		SAP130_ENST00000259234.6_Splice_Site|SAP130_ENST00000259235.3_Splice_Site	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa						histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TTTTGGTTTTACCTGAGCCAT	0.483													13	51					0	0	1	0	0	C	128757879	A	C	128757879	5	2	5	1	0	0	0	0	0	0	1	0	13882	405	14	4	2210	4	SAP130	2	128757879	Splice_Site	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08	16070942	128757879	114441494	10	281										
RAPGEF4	11069	broad.mit.edu	37	chr2	173830397	173830397	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gcaagtcctgttagaagatgGtgttctcaaccacggtaaga	11	8	1	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr2:173830397G>T	ENST00000264111.6	+	9	990	c.803G>T	c.(802-804)gGt>gTt	p.G268V	RAPGEF4_ENST00000539331.1_Missense_Mutation_p.G116V|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.G269V|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.G269V|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.G125V|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.G116V|RAPGEF4_ENST00000538974.1_Missense_Mutation_p.G98V|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.G49V|RAPGEF4_ENST00000473043.1_3'UTR			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	269	DEP.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTAGAAGATGGTGTTCTCAAC	0.502													4	85					0.00909568	0.00929559	1	1	0	T	173830397	G	T	173830397	3	4	5	1	0	0	0	0	1	0	0	0	13097	1261	44	5	856	5	RAPGEF4	2	173830397	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	45072518	173830397	69368976	11	282										
GRM7	2917	broad.mit.edu	37	chr3	7188289	7188289	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gctggaattatgtgtctaccCtcgcatcggaaggaagttat	11	8	1	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr3:7188289C>A	ENST00000486284.1	+	2	944	c.670C>A	c.(670-672)Ctc>Atc	p.L224I	GRM7_ENST00000389336.4_Missense_Mutation_p.L224I|GRM7_ENST00000402647.2_Missense_Mutation_p.L224I|GRM7_ENST00000357716.4_Missense_Mutation_p.L224I|GRM7_ENST00000403881.1_Missense_Mutation_p.L224I	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	224					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TGTGTCTACCCTCGCATCGGA	0.522													8	48					0.00621372	0.00649298	1	1	0	A	7188289	C	A	7188289	3	1	5	1	0	0	0	0	1	0	0	0	6842	681	24	5	676	5	GRM7	3	7188289	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		7188289	190834141	12	283										
COL7A1	1294	broad.mit.edu	37	chr3	48603954	48603954	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cacactcaccgtcagtgcagCttctcccttctcgcctcgag	7	18	4	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr3:48603954C>G	ENST00000328333.8	-	112	8454	c.8347G>C	c.(8347-8349)Gct>Cct	p.A2783P	COL7A1_ENST00000454817.1_Missense_Mutation_p.A2751P	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2783	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCAGTGCAGCTTCTCCCTTC	0.672													7	106					0	0	1	0	0	G	48603954	C	G	48603954	3	3	5	1	0	0	0	0	1	0	0	0	3727	797	28	5	515	5	COL7A1	3	48603954	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	41415665	48603954	149418476	13	284										
IP6K1	9807	broad.mit.edu	37	chr3	49764567	49764567	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aacagggcctactggttctcGtcccgcatctgttccatgat	9	13	2	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr3:49764567G>C	ENST00000321599.4	-	6	1615	c.1314C>G	c.(1312-1314)gaC>gaG	p.D438E	IP6K1_ENST00000395238.1_Missense_Mutation_p.D273E|IP6K1_ENST00000468463.1_3'UTR|IP6K1_ENST00000460540.1_Missense_Mutation_p.D273E	NM_001242829.1|NM_153273.3	NP_001229758.1|NP_695005.1	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1	438					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity	p.D438D(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	15						ACTGGTTCTCGTCCCGCATCT	0.587													31	28					0	0	1	0	0	C	49764567	G	C	49764567	3	2	5	1	0	0	0	0	1	0	0	0	7831	1136	40	5	15	5	IP6K1	3	49764567	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	1160613	49764567	148257863	14	285										
SHQ1	55164	broad.mit.edu	37	chr3	72799764	72799764	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tgaatctgagcctgagtcttCgtttccagatgacacgctgc	10	11	2	5			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr3:72799764C>G	ENST00000325599.8	-	11	1544	c.1405G>C	c.(1405-1407)Gaa>Caa	p.E469Q	SHQ1_ENST00000463369.1_Missense_Mutation_p.E441Q|SHQ1_ENST00000468371.1_5'UTR	NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	469	Ser-rich.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		CCTGAGTCTTCGTTTCCAGAT	0.473													16	19					0	0	1	0	0	G	72799764	C	G	72799764	3	3	5	1	0	0	0	0	1	0	0	0	14346	893	31	2	332	2	SHQ1	3	72799764	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	23035197	72799764	125222666	15	286										
CD80	941	broad.mit.edu	37	chr3	119276562	119276562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	atggtgatgttccctgcctcCgtgtgtggcccatggcttca	12	12	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr3:119276562C>T	ENST00000264246.3	-	2	376	c.14G>A	c.(13-15)cGg>cAg	p.R5Q	CD80_ENST00000383668.3_Missense_Mutation_p.R5Q|CD80_ENST00000478182.1_Missense_Mutation_p.R5Q|CD80_ENST00000383669.3_Missense_Mutation_p.R5Q	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	5					interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	TCCCTGCCTCCGTGTGTGGCC	0.498													9	17					0	0	1	0	0	T	119276562	C	T	119276562	3	4	5	1	0	0	0	0	1	0	0	0	3060	652	23	1	872	1	CD80	3	119276562	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	46476798	119276562	78745868	16	287										
PIK3CA	5290	broad.mit.edu	37	chr3	178952084	178952084	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tgaaacaaatgaatgatgcaCatcatggtggctggacaaca	10	7	1	3	rs121913281		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr3:178952084C>T	ENST00000263967.3	+	21	3296	c.3139C>T	c.(3139-3141)Cat>Tat	p.H1047Y		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047Y(37)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAATGATGCACATCATGGTGG	0.373	H1047Y(MFE280_ENDOMETRIUM)|H1047Y(TOV21G_OVARY)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			36	40					0	0	1	0	0	T	178952084	C	T	178952084	3	4	5	1	0	0	0	0	1	0	0	0	11960	478	17	3	3217	3	PIK3CA	3	178952084	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	59675522	178952084	19070346	17	288										
THAP9	79725	broad.mit.edu	37	chr4	83826061	83826061	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gaaagctgaaaaaaggagctGtgccttctgtttctctatac	9	8	2	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr4:83826061G>A	ENST00000302236.5	+	2	304	c.253G>A	c.(253-255)Gtg>Atg	p.V85M		NM_024672.4	NP_078948.3	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	85							DNA binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(13)|lung(5)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(3)	33		Hepatocellular(203;0.114)				AAAAGGAGCTGTGCCTTCTGT	0.363													8	17					0	0	1	0	0	A	83826061	G	A	83826061	3	1	5	1	0	0	0	0	1	0	0	0	15910	1377	48	3	259	3	THAP9	4	83826061	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		83826061	107328215	18	289										
FBXW7	0	broad.mit.edu	37	chr4	153251907	153251907	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aggagatttgagttctcctcGcctccagttagtatcaattc	8	10	2	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr4:153251907G>A	ENST00000281708.4	-	7	2328	c.1099C>T	c.(1099-1101)Cga>Tga	p.R367*	FBXW7_ENST00000263981.5_Nonsense_Mutation_p.R287*|FBXW7_ENST00000603841.1_Nonsense_Mutation_p.R367*|FBXW7_ENST00000603548.1_Nonsense_Mutation_p.R367*|FBXW7_ENST00000393956.3_Nonsense_Mutation_p.R191*|FBXW7_ENST00000296555.5_Nonsense_Mutation_p.R249*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	367					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R367*(10)|p.R287*(3)|p.R128*(3)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTTCTCCTCGCCTCCAGTTA	0.388			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								17	33					0	0	1	0	0	A	153251907	G	A	153251907	4	1	5	1	0	0	0	0	0	1	0	0	5801	1095	38	1	1048	1	FBXW7	4	153251907	Nonsense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	69425846	153251907	37902369	19	290										
IRX1	79192	broad.mit.edu	37	chr5	3600104	3600104	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ccggcgcgcacgggccctccGccggggcgccgctgcaacac	15	20	0	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr5:3600104G>A	ENST00000302006.3	+	2	1094	c.1042G>A	c.(1042-1044)Gcc>Acc	p.A348T	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	348						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						cgggccctccgccggggcgcc	0.706													7	0					0	0	1	0	0	A	3600104	G	A	3600104	3	1	5	1	0	0	0	0	1	0	0	0	7886	1087	38	1	1048	1	IRX1	5	3600104	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		3600104	177315156	20	291										
NIPBL	25836	broad.mit.edu	37	chr5	37049341	37049341	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ttcacacccagtcaagtgtaCgccactttgccctaaatgtc	6	14	2	0	rs80358376		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr5:37049341C>T	ENST00000282516.8	+	40	7391	c.6892C>T	c.(6892-6894)Cgc>Tgc	p.R2298C	NIPBL_ENST00000448238.2_Missense_Mutation_p.R2298C	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2298			R -> C (in CDLS1).|R -> H (in CDLS1).		brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GTCAAGTGTACGCCACTTTGC	0.413													21	134					0	0	1	0	0	T	37049341	C	T	37049341	3	4	5	1	0	0	0	0	1	0	0	0	10474	536	19	1	7046	1	NIPBL	5	37049341	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	33449237	37049341	143865919	21	292										
FAM169A	26049	broad.mit.edu	37	chr5	74137476	74137476	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	attcctcatggctgcaatttTccagcatatccacagggaat	7	11	1	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr5:74137476T>C	ENST00000389156.4	-	2	116	c.26A>G	c.(25-27)gAa>gGa	p.E9G	FAM169A_ENST00000510496.1_Missense_Mutation_p.E9G|FAM169A_ENST00000380515.3_Missense_Mutation_p.E9G	NM_015566.2	NP_056381.1	Q9Y6X4	F169A_HUMAN	family with sequence similarity 169, member A	9										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	27						GCTGCAATTTTCCAGCATATC	0.378													10	41					0	0	1	0	0	C	74137476	T	C	74137476	3	2	5	1	0	0	0	0	1	0	0	0	5516	1783	62	4	2034	4	FAM169A	5	74137476	Missense_Mutation	SNP	T	TCGA-N5-A4RJ-01A-11D-A28R-08	37088135	74137476	106777784	22	293										
MAML1	9794	broad.mit.edu	37	chr5	179195869	179195869	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aggagcagaacccttccagtGtccctgtgcaagcccaggct	11	14	0	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr5:179195869G>A	ENST00000292599.3	+	3	2013	c.1750G>A	c.(1750-1752)Gtc>Atc	p.V584I	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	584					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTTCCAGTGTCCCTGTGCA	0.562													67	149					0	0	1	0	0	A	179195869	G	A	179195869	3	1	5	1	0	0	0	0	1	0	0	0	9254	1377	48	3	1760	3	MAML1	5	179195869	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	105058393	179195869	1719391	23	294										
KIAA0319	9856	broad.mit.edu	37	chr6	24566850	24566850	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ctgctggactctggccatccCggatccacagataggacaca	10	14	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr6:24566850C>A	ENST00000535378.1	-	15	2882	c.2240G>T	c.(2239-2241)cGg>cTg	p.R747L	KIAA0319_ENST00000537886.1_Missense_Mutation_p.R756L|KIAA0319_ENST00000378214.3_Missense_Mutation_p.R756L|KIAA0319_ENST00000543707.1_Missense_Mutation_p.R756L|KIAA0319_ENST00000430948.2_Missense_Mutation_p.R711L	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	756	PKD 5.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CTGGCCATCCCGGATCCACAG	0.463													10	78					6.42651e-13	7.37859e-13	1	1	0	A	24566850	C	A	24566850	3	1	5	1	0	0	0	0	1	0	0	0	8209	652	23	5	983	5	KIAA0319	6	24566850	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		24566850	146548217	24	295										
KIAA0319	9856	broad.mit.edu	37	chr6	24596359	24596359	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	agtaggccccagtccgtgtaCtcggcactccctctgggctc	11	16	1	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr6:24596359C>T	ENST00000535378.1	-	4	1158	c.516G>A	c.(514-516)gaG>gaA	p.E172E	KIAA0319_ENST00000537886.1_Silent_p.E181E|KIAA0319_ENST00000378214.3_Silent_p.E181E|KIAA0319_ENST00000543707.1_Silent_p.E181E|KIAA0319_ENST00000430948.2_Silent_p.E136E	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	181					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						AGTCCGTGTACTCGGCACTCC	0.637													31	31					0	0	1	0	0	T	24596359	C	T	24596359	2	4	5	1	0	0	0	0	0	0	0	1	8209	564	20	3		3	KIAA0319	6	24596359	Silent	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	29509	24596359	146518708	25	296										
CUL9	23113	broad.mit.edu	37	chr6	43155158	43155159	+	Frame_Shift_Del	DEL	TT	TT	-													0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gcagccaattttccagaatcTttggaagaacctggatgagg							TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr6:43155158_43155159delTT	ENST00000252050.4	+	6	1646_1647	c.1562_1563delTT	c.(1561-1563)cfs	p.L521fs	CUL9_ENST00000372647.2_Frame_Shift_Del_p.L521fs|CUL9_ENST00000354495.3_Intron	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	521					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						TTCCAGAATCTTTGGAAGAACC	0.45													62	64	---	---	---	---						-	43155159	TT	-	43155158	7	5	5	1	0	1	0	1	0	0	0	0	4084	1609	56	0	1580	0	CUL9	6	43155158	Frame_Shift_Del	DEL	TT	TCGA-N5-A4RJ-01A-11D-A28R-08	18558799	43155158	127959909	26	297										
SYNE1	23345	broad.mit.edu	37	chr6	152554983	152554983	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tccactggctatcaatgcgcGacagctcagagcgcagcgtg	12	13	2	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr6:152554983G>A	ENST00000367255.5	-	112	21246	c.20645C>T	c.(20644-20646)tCg>tTg	p.S6882L	SYNE1_ENST00000341594.5_Missense_Mutation_p.S6494L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S6882L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S6811L|SYNE1_ENST00000423061.1_Missense_Mutation_p.S6811L|SYNE1_ENST00000356820.4_Missense_Mutation_p.S1406L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6882					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCAATGCGCGACAGCTCAGA	0.512										HNSCC(10;0.0054)			24	38					0	0	1	0	0	A	152554983	G	A	152554983	3	1	5	1	0	0	0	0	1	0	0	0	15501	1059	37	1	5961	1	SYNE1	6	152554983	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	109399825	152554983	18560084	27	298										
MAP3K4	4216	broad.mit.edu	37	chr6	161530808	161530808	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aagaaatgtacatcttcatgGagtactgcgatgaggggact	12	6	2	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr6:161530808G>T	ENST00000392142.4	+	23	4406	c.4258G>T	c.(4258-4260)Gag>Tag	p.E1420*	MAP3K4_ENST00000348824.7_Nonsense_Mutation_p.E1366*|MAP3K4_ENST00000366919.2_Nonsense_Mutation_p.E1370*|MAP3K4_ENST00000366920.2_Nonsense_Mutation_p.E1416*	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1420	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CATCTTCATGGAGTACTGCGA	0.443													35	33					9.04072e-19	1.05098e-18	1	1	0	T	161530808	G	T	161530808	4	4	5	1	0	0	0	0	0	1	0	0	9301	1175	41	2	4348	2	MAP3K4	6	161530808	Nonsense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	8975825	161530808	9584259	28	299										
DGKB	1607	broad.mit.edu	37	chr7	14741318	14741318	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aaaattaccgagctgtccagGaagccattcccatccgtgtc	8	13	0	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr7:14741318G>A	ENST00000403951.2	-	7	923	c.504C>T	c.(502-504)ttC>ttT	p.F168F	DGKB_ENST00000407950.1_Silent_p.F161F|DGKB_ENST00000406247.3_Silent_p.F168F|DGKB_ENST00000402815.1_Silent_p.F168F|DGKB_ENST00000399322.3_Silent_p.F168F|DGKB_ENST00000258767.5_Silent_p.F168F|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000444700.2_Silent_p.F161F			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	168	EF-hand 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	AGCTGTCCAGGAAGCCATTCC	0.328													8	25					0	0	1	0	0	A	14741318	G	A	14741318	2	1	5	1	0	0	0	0	0	0	0	1	4494	1165	41	3		3	DGKB	7	14741318	Silent	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		14741318	144397345	29	300										
CALN1	83698	broad.mit.edu	37	chr7	71743757	71743757	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tgaggtaattccccttgtacAacaagccggcggtcacatgg	11	11	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr7:71743757A>G	ENST00000395275.2	-	3	546	c.158T>C	c.(157-159)tTg>tCg	p.L53S	CALN1_ENST00000431984.1_Missense_Mutation_p.L11S|CALN1_ENST00000395276.2_Missense_Mutation_p.L11S|CALN1_ENST00000405452.2_Missense_Mutation_p.L11S|CALN1_ENST00000412588.1_Missense_Mutation_p.L53S|CALN1_ENST00000329008.5_Missense_Mutation_p.L11S	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	11	EF-hand 1.					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CCCCTTGTACAACAAGCCGGC	0.522													12	27					0	0	1	0	0	G	71743757	A	G	71743757	3	3	5	1	0	0	0	0	1	0	0	0	2609	131	5	4	647	4	CALN1	7	71743757	Missense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08	57002439	71743757	87394906	30	301										
ZAN	7455	broad.mit.edu	37	chr7	100384030	100384033	+	RNA	DEL	TTGT	TTGT	-													0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cctccaaagtttttcttttcTtgtttgtttgttttttgaga					rs71973809		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr7:100384030_100384033delTTGT	ENST00000542585.1	+	0	7124				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ttttcttttcttgtttgtttgttt	0.505													4	2	---	---	---	---						-	100384033	TTGT	-	100384030	6	5	5	0	1	1	0	1	0	0	0	0	17572	1624	56	0		0	ZAN	7	100384030	RNA	DEL	TTGT	TCGA-N5-A4RJ-01A-11D-A28R-08	28640273	100384030	58754633	31	302										
LRRC4	64101	broad.mit.edu	37	chr7	127670549	127670549	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ctggttactgcacgagcagaCggaggggcagttctggggcc	17	10	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr7:127670549C>G	ENST00000249363.3	-	2	402	c.145G>C	c.(145-147)Gtc>Ctc	p.V49L	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	49	LRRNT.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		CACGAGCAGACGGAGGGGCAG	0.647													5	126					0	0	1	0	0	G	127670549	C	G	127670549	3	3	5	1	0	0	0	0	1	0	0	0	9041	536	19	5	1820	5	LRRC4	7	127670549	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	27286519	127670549	31468114	32	303										
GIMAP4	55303	broad.mit.edu	37	chr7	150269569	150269569	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cacaaagccacagagaagatCctgaaaatgtttggagagag	11	7	0	4			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr7:150269569C>A	ENST00000255945.2	+	3	586	c.411C>A	c.(409-411)atC>atA	p.I137I	GIMAP4_ENST00000461940.1_Silent_p.I151I|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	137							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGAGAAGATCCTGAAAATGT	0.483													17	44					1.15088e-07	1.27419e-07	1	1	0	A	150269569	C	A	150269569	2	1	5	1	0	0	0	0	0	0	0	1	6422	845	30	2		2	GIMAP4	7	150269569	Silent	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	22599020	150269569	8869094	33	304										
LZTS1	11178	broad.mit.edu	37	chr8	20107496	20107496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ttgccgctcctcccgcagctCggcccgcagccgctccagct	10	21	0	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr8:20107496C>T	ENST00000381569.1	-	4	1885	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	LZTS1_ENST00000522290.1_Intron|LZTS1_ENST00000265801.6_Missense_Mutation_p.E510K			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	510					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TCCCGCAGCTCGGCCCGCAGC	0.701													36	13					0	0	1	0	0	T	20107496	C	T	20107496	3	4	5	1	0	0	0	0	1	0	0	0	9183	893	31	1	266	1	LZTS1	8	20107496	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		20107496	126256526	34	305										
PRKCQ	5588	broad.mit.edu	37	chr10	6506275	6506275	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aaccctttaaagcctcttacGtcgctctggaaaggtcgaac	8	12	2	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr10:6506275G>A	ENST00000263125.5	-	13	1544	c.1445_splice	c.e13+1	p.T482_splice	PRKCQ_ENST00000539722.1_Splice_Site_p.T357_splice|PRKCQ_ENST00000397176.2_Splice_Site_p.T482_splice	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	482	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						AGCCTCTTACGTCGCTCTGGA	0.458													175	210					0	0	1	0	0	A	6506275	G	A	6506275	5	1	5	1	0	0	0	0	0	0	1	0	12566	1159	40	1	699	1	PRKCQ	10	6506275	Splice_Site	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		6506275	129028472	35	306										
SFMBT2	57713	broad.mit.edu	37	chr10	7214029	7214029	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ccgagggcacctccgccgacGaggtgtccgtctggtcatcc	13	16	2	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr10:7214029G>A	ENST00000361972.4	-	19	2333	c.2243C>T	c.(2242-2244)tCg>tTg	p.S748L	SFMBT2_ENST00000397167.1_Missense_Mutation_p.S748L	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	748					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						CTCCGCCGACGAGGTGTCCGT	0.711													5	22					0	0	1	0	0	A	7214029	G	A	7214029	3	1	5	1	0	0	0	0	1	0	0	0	14211	1059	37	1	453	1	SFMBT2	10	7214029	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	707754	7214029	128320718	36	307										
MS4A15	219995	broad.mit.edu	37	chr11	60541407	60541407	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cttcgggtgccaagccatccAtgcccaggccagtgcagtga	12	14	0	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr11:60541407A>T	ENST00000405633.3	+	6	675	c.596A>T	c.(595-597)cAt>cTt	p.H199L	MS4A15_ENST00000337911.4_Missense_Mutation_p.H106L|MS4A15_ENST00000528170.1_Missense_Mutation_p.H158L	NM_001098835.1	NP_001092305.1	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member 15	199						integral to membrane	receptor activity			breast(1)|large_intestine(2)|lung(3)	6						CAAGCCATCCATGCCCAGGCC	0.607													57	6					0	0	1	0	0	T	60541407	A	T	60541407	3	4	5	1	0	0	0	0	1	0	0	0	9907	217	8	4	614	4	MS4A15	11	60541407	Missense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08		60541407	74465109	37	308										
CD248	57124	broad.mit.edu	37	chr11	66082813	66082813	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gcttgagggggtagctgggcAccgagggtggtgaccagagg	21	7	0	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr11:66082813A>G	ENST00000311330.3	-	1	1702	c.1686T>C	c.(1684-1686)ggT>ggC	p.G562G	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	562	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	GTAGCTGGGCACCGAGGGTGG	0.622													47	54					0	0	1	0	0	G	66082813	A	G	66082813	2	3	5	1	0	0	0	0	0	0	0	1	3011	146	6	4		4	CD248	11	66082813	Silent	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08	5541406	66082813	68923703	38	309										
LMO3	55885	broad.mit.edu	37	chr12	16704161	16704161	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ggtgatgttgatagatcagcGaacctggggtgcataacctt	13	7	1	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr12:16704161G>A	ENST00000320122.6	-	4	955	c.433C>T	c.(433-435)Cgc>Tgc	p.R145C	LMO3_ENST00000537304.1_Missense_Mutation_p.R145C|LMO3_ENST00000541846.1_Missense_Mutation_p.R145C|LMO3_ENST00000447609.1_Missense_Mutation_p.R145C|LMO3_ENST00000541295.1_Missense_Mutation_p.R163C|LMO3_ENST00000441439.2_Missense_Mutation_p.R145C|LMO3_ENST00000354662.1_Missense_Mutation_p.R145C|LMO3_ENST00000540848.1_Missense_Mutation_p.R145C|LMO3_ENST00000534946.1_Missense_Mutation_p.R145C|LMO3_ENST00000535535.1_Missense_Mutation_p.R145C|LMO3_ENST00000261169.6_Missense_Mutation_p.R156C|LMO3_ENST00000540445.1_Missense_Mutation_p.R167C	NM_001243611.1	NP_001230540.1	Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				ATAGATCAGCGAACCTGGGGT	0.378													28	12					0	0	1	0	0	A	16704161	G	A	16704161	3	1	5	1	0	0	0	0	1	0	0	0	8893	1058	37	1	8	1	LMO3	12	16704161	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		16704161	117147734	39	310										
MSRB3	253827	broad.mit.edu	37	chr12	65857094	65857094	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cggcccaggcagacaaagcgGagctctagagtaatggagag	15	9	1	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr12:65857094G>A	ENST00000308259.5	+	7	824	c.550G>A	c.(550-552)Gag>Aag	p.E184K	MSRB3_ENST00000535664.1_Missense_Mutation_p.E184K|MSRB3_ENST00000355192.3_Missense_Mutation_p.E191K	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	191					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		AGACAAAGCGGAGCTCTAGAG	0.448													18	31					0	0	1	0	0	A	65857094	G	A	65857094	3	1	5	1	0	0	0	0	1	0	0	0	9936	1175	41	3	673	3	MSRB3	12	65857094	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	49152933	65857094	67994801	40	311										
GTF3A	2971	broad.mit.edu	37	chr13	28009312	28009312	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ttgtacatgatcctgacaagAagaaaatgaagctcaaagta	8	6	1	5			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr13:28009312A>T	ENST00000381140.4	+	8	1110	c.916A>T	c.(916-918)Aag>Tag	p.K306*	GTF3A_ENST00000470606.1_3'UTR	NM_002097.2	NP_002088.2	Q92664	TF3A_HUMAN	general transcription factor IIIA	306					regulation of transcription, DNA-dependent|rRNA transcription|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|lung(1)	2		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.11)|OV - Ovarian serous cystadenocarcinoma(117;0.158)		TCCTGACAAGAAGAAAATGAA	0.338													29	23					0	0	1	0	0	T	28009312	A	T	28009312	4	4	5	1	0	0	0	0	0	1	0	0	6911	247	9	4	946	4	GTF3A	13	28009312	Nonsense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08		28009312	87160566	41	312										
KBTBD7	84078	broad.mit.edu	37	chr13	41768108	41768108	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	acctgtgaacatgctcttgaAgtagggacacgcagctgcta	11	10	1	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr13:41768108A>C	ENST00000379483.3	-	1	594	c.286T>G	c.(286-288)Ttc>Gtc	p.F96V		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	96	BTB.						protein binding	p.Y95fs*42(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		ATGCTCTTGAAGTAGGGACAC	0.602													20	27					0	0	1	0	0	C	41768108	A	C	41768108	3	2	5	1	0	0	0	0	1	0	0	0	8041	72	3	4	1772	4	KBTBD7	13	41768108	Missense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08	13758796	41768108	73401770	42	313										
MED4	29079	broad.mit.edu	37	chr13	48654103	48654103	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	atcagttgggtagggtctccGggggtcccctaaaacaataa	12	9	2	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr13:48654103G>A	ENST00000258648.2	-	6	542	c.517C>T	c.(517-519)Cgg>Tgg	p.R173W	MED4_ENST00000495013.1_5'UTR|MED4-AS1_ENST00000422483.1_RNA|MED4_ENST00000378586.1_Missense_Mutation_p.R127W	NM_014166.2	NP_054885.1	Q9NPJ6	MED4_HUMAN	mediator complex subunit 4	173					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)	8		all_cancers(8;2.93e-25)|all_epithelial(8;4.38e-13)|all_lung(13;7.37e-06)|all_hematologic(8;8.61e-05)|Breast(56;0.000141)|Lung NSC(96;0.000518)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.00559)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;5.18e-07)		TAGGGTCTCCGGGGGTCCCCT	0.393													14	28					0	0	1	0	0	A	48654103	G	A	48654103	3	1	5	1	0	0	0	0	1	0	0	0	9499	1115	39	1	303	1	MED4	13	48654103	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	6885995	48654103	66515775	43	314										
NOVA1	4857	broad.mit.edu	37	chr14	26941517	26941517	+	Frame_Shift_Del	DEL	A	A	-													0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	atggtgtagatgacaggatgAtactgtacctgattagctct							TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr14:26941517delA	ENST00000547619.1	-	4	586	c.528delT	c.(526-528)tafs	p.Y176fs	NOVA1_ENST00000344429.5_Intron|NOVA1_ENST00000267422.7_Intron|NOVA1_ENST00000539517.2_Intron|NOVA1_ENST00000465357.2_Intron			P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	0	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TGACAGGATGATACTGTACCT	0.438													6	7	---	---	---	---						-	26941517	A	-	26941517	7	5	5	1	0	1	0	1	0	0	0	0	10600	348	12	0		0	NOVA1	14	26941517	Frame_Shift_Del	DEL	A	TCGA-N5-A4RJ-01A-11D-A28R-08		26941517	80408023	44	315										
MAZ	4150	broad.mit.edu	37	chr16	29821543	29821543	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tctcagccacttccctcccaAccctggtgagctccaagttg	7	17	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr16:29821543A>T	ENST00000322945.6	+	5	1590	c.1425A>T	c.(1423-1425)caA>caT	p.Q475H	MAZ_ENST00000566906.2_Missense_Mutation_p.T130S|MAZ_ENST00000545521.1_Missense_Mutation_p.Q452H|MAZ_ENST00000568544.1_Missense_Mutation_p.Q76H|AC009133.14_ENST00000569981.1_RNA|MAZ_ENST00000563402.1_Missense_Mutation_p.T132S|AC009133.20_ENST00000569039.1_RNA|MAZ_ENST00000568282.1_3'UTR|MAZ_ENST00000219782.6_3'UTR|MAZ_ENST00000562337.1_Missense_Mutation_p.Q170H	NM_002383.2	NP_002374.2	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	475					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						TTCCCTCCCAACCCTGGTGAG	0.637													15	6					0	0	1	0	0	T	29821543	A	T	29821543	3	4	5	1	0	0	0	0	1	0	0	0	9389	40	2	4	1650	4	MAZ	16	29821543	Missense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08		29821543	60533210	45	316										
VPS53	55275	broad.mit.edu	37	chr17	556625	556625	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	aaggagattagcaacttctcCgtattgtcttcgcctggtca	9	10	3	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:556625C>T	ENST00000437048.2	-	7	660	c.514G>A	c.(514-516)Gga>Aga	p.G172R	VPS53_ENST00000574029.1_Intron|VPS53_ENST00000571805.1_Missense_Mutation_p.G172R|VPS53_ENST00000291074.5_Missense_Mutation_p.G143R|VPS53_ENST00000401468.3_Intron|VPS53_ENST00000446250.2_5'UTR|VPS53_ENST00000576149.1_Intron	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	172					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GCAACTTCTCCGTATTGTCTT	0.458													21	26					0	0	1	0	0	T	556625	C	T	556625	3	4	5	1	0	0	0	0	1	0	0	0	17274	661	23	1	2063	1	VPS53	17	556625	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		556625	80638585	46	317										
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:7578406C>T	ENST00000420246.2	-	5	656	c.524G>A	c.(523-525)cGc>cAc	p.R175H	TP53_ENST00000359597.4_Missense_Mutation_p.R175H|TP53_ENST00000269305.4_Missense_Mutation_p.R175H|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000455263.2_Missense_Mutation_p.R175H|TP53_ENST00000445888.2_Missense_Mutation_p.R175H|TP53_ENST00000413465.2_Missense_Mutation_p.R175H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	175	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(847)|p.R43H(36)|p.R82H(36)|p.R175L(19)|p.0?(8)|p.R175P(6)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*5(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(AU565_BREAST)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(HCC1395_BREAST)|R175H(HUCCT1_BILIARY_TRACT)|R175H(KLE_ENDOMETRIUM)|R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(LS123_LARGE_INTESTINE)|R175H(NCIH196_LUNG)|R175H(RKN_OVARY)|R175H(SKBR3_BREAST)|R175H(SKUT1_SOFT_TISSUE)|R175H(TYKNU_OVARY)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	7					0	0	1	0	0	T	7578406	C	T	7578406	3	4	5	1	0	0	0	0	1	0	0	0	16441	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	7021781	7578406	73616804	47	318										
DHRS7C	201140	broad.mit.edu	37	chr17	9676126	9676126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gtttccttgctctggatacaCgtggtacgaccggatgaaag	12	9	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:9676126C>T	ENST00000330255.4	-	5	700	c.688G>A	c.(688-690)Gtg>Atg	p.V230M	DHRS7C_ENST00000571134.1_Missense_Mutation_p.V229M	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	230						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TCTGGATACACGTGGTACGAC	0.582													32	7					0	0	1	0	0	T	9676126	C	T	9676126	3	4	5	1	0	0	0	0	1	0	0	0	4525	536	19	1	258	1	DHRS7C	17	9676126	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	2097720	9676126	71519084	48	319										
DNAH9	1770	broad.mit.edu	37	chr17	11711183	11711183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tgtcttccagatcacactgcGcaaaggctaccagatccagg	9	13	2	2	rs146734343	byFrequency	TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:11711183G>A	ENST00000262442.3	+	44	8623	c.8555G>A	c.(8554-8556)cGc>cAc	p.R2852H	DNAH9_ENST00000454412.2_Missense_Mutation_p.R2852H	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2852	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ATCACACTGCGCAAAGGCTAC	0.557													3	32					0	0	1	0	0	A	11711183	G	A	11711183	3	1	5	1	0	0	0	0	1	0	0	0	4635	1087	38	1	8729	1	DNAH9	17	11711183	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	2035057	11711183	69484027	49	320										
ALDH3A1	218	broad.mit.edu	37	chr17	19642904	19642904	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ggcctcctccaggctgcgcaCgcacacgatgggcagcacag	13	16	0	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:19642904C>T	ENST00000457500.2	-	7	1362	c.1033G>A	c.(1033-1035)Gtg>Atg	p.V345M	ALDH3A1_ENST00000494157.2_Missense_Mutation_p.V272M|ALDH3A1_ENST00000225740.6_Missense_Mutation_p.V345M|ALDH3A1_ENST00000395555.3_Missense_Mutation_p.V281M|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.V345M	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	345					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	AGGCTGCGCACGCACACGATG	0.632													9	19					0	0	1	0	0	T	19642904	C	T	19642904	3	4	5	1	0	0	0	0	1	0	0	0	494	536	19	1	344	1	ALDH3A1	17	19642904	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	7931721	19642904	61552306	50	321										
CCL1	6346	broad.mit.edu	37	chr17	32687649	32687649	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ccatccaactgtgtccaaggCgcaggcctctttgcctctct	8	16	2	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:32687649C>T	ENST00000225842.3	-	3	289	c.220G>A	c.(220-222)Gcc>Acc	p.A74T		NM_002981.1	NP_002972.1	P22362	CCL1_HUMAN	chemokine (C-C motif) ligand 1	74					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity						Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GTGTCCAAGGCGCAGGCCTCT	0.522													56	89					0	0	1	0	0	T	32687649	C	T	32687649	3	4	5	1	0	0	0	0	1	0	0	0	2902	768	27	1	74	1	CCL1	17	32687649	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	13044745	32687649	48507561	51	322										
RASL10B	91608	broad.mit.edu	37	chr17	34062267	34062267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tgggcaagagtgccatcgtgCgccagttcttgtacaacgag	13	10	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:34062267C>T	ENST00000268864.3	+	2	441	c.64C>T	c.(64-66)Cgc>Tgc	p.R22C		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	22	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCCATCGTGCGCCAGTTCTT	0.672													31	42					0	0	1	0	0	T	34062267	C	T	34062267	3	4	5	1	0	0	0	0	1	0	0	0	13131	768	27	1	66	1	RASL10B	17	34062267	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	1374618	34062267	47132943	52	323										
ERBB2	2064	broad.mit.edu	37	chr17	37881332	37881332	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	acctggaggatgtgcggctcGtacacagggacttggccgct	15	11	0	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:37881332G>A	ENST00000406381.2	+	23	2944	c.2434G>A	c.(2434-2436)Gta>Ata	p.V812I	ERBB2_ENST00000584450.1_Missense_Mutation_p.V842I|ERBB2_ENST00000445658.2_Missense_Mutation_p.V566I|ERBB2_ENST00000584601.1_Missense_Mutation_p.V812I|ERBB2_ENST00000269571.5_Missense_Mutation_p.V842I|ERBB2_ENST00000541774.1_Missense_Mutation_p.V827I|ERBB2_ENST00000540147.1_Missense_Mutation_p.V812I	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	842	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V842I(6)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGTGCGGCTCGTACACAGGGA	0.597		1	"A, Mis, O"		"breast, ovarian, other tumour types, NSCLC, gastric"					TCGA GBM(5;<1E-08)			43	57					0	0	1	0	0	A	37881332	G	A	37881332	3	1	5	1	0	0	0	0	1	0	0	0	5234	1145	40	1	2606	1	ERBB2	17	37881332	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	3819065	37881332	43313878	53	324										
DHX58	79132	broad.mit.edu	37	chr17	40253875	40253875	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cgggaccactttttggcctgGatccgcccctgaggggtctc	13	14	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:40253875G>C	ENST00000251642.3	-	14	2163	c.1941C>G	c.(1939-1941)atC>atG	p.I647M		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	647	RNA-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTTTGGCCTGGATCCGCCCCT	0.592											OREG0024418	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	60					0	0	1	0	0	C	40253875	G	C	40253875	3	2	5	1	0	0	0	0	1	0	0	0	4542	1164	41	2	99	2	DHX58	17	40253875	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	2372543	40253875	40941335	54	325										
RNF213	57674	broad.mit.edu	37	chr17	78346514	78346514	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cagagctgcagatttcctctCggagcctgagggaggcccag	14	12	1	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr17:78346514C>T	ENST00000582970.1	+	48	12874	c.12731C>T	c.(12730-12732)tCg>tTg	p.S4244L	CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Missense_Mutation_p.S4293L|RNF213_ENST00000336301.6_Missense_Mutation_p.S2317L|CTD-2047H16.4_ENST00000575034.1_RNA	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	280										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GATTTCCTCTCGGAGCCTGAG	0.557													23	26					0	0	1	0	0	T	78346514	C	T	78346514	3	4	5	1	0	0	0	0	1	0	0	0	13528	893	31	1	13236	1	RNF213	17	78346514	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	38092639	78346514	2848696	55	326										
SMARCA4	6597	broad.mit.edu	37	chr19	11170774	11170774	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ggaaggagaaggcacaggacCggctgaagggcggccggcgg	21	9	0	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr19:11170774C>T	ENST00000358026.2	+	35	5202	c.4918C>T	c.(4918-4920)Cgg>Tgg	p.R1640W	SMARCA4_ENST00000429416.3_Missense_Mutation_p.R1608W|SMARCA4_ENST00000541122.2_Missense_Mutation_p.R1578W|SMARCA4_ENST00000344626.4_Missense_Mutation_p.R1608W|SMARCA4_ENST00000444061.3_Missense_Mutation_p.R1574W|SMARCA4_ENST00000413806.3_Missense_Mutation_p.R1578W|SMARCA4_ENST00000450717.3_Missense_Mutation_p.R1577W|SMARCA4_ENST00000590574.1_Missense_Mutation_p.R1575W|SMARCA4_ENST00000589677.1_Missense_Mutation_p.R1577W	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1608					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGCACAGGACCGGCTGAAGGG	0.652			"F, N, Mis"		NSCLC								3	7					0	0	1	0	0	T	11170774	C	T	11170774	3	4	5	1	0	0	0	0	1	0	0	0	14823	643	23	1	5061	1	SMARCA4	19	11170774	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		11170774	47958209	56	327										
OR1I1	126370	broad.mit.edu	37	chr19	15198440	15198440	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	atgcccctgctgaagctctcCggctcagacacgcacaccaa	8	17	2	2	rs147792989	byFrequency	TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr19:15198440C>T	ENST00000209540.2	+	1	650	c.564C>T	c.(562-564)tcC>tcT	p.S188S		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S188S(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						TGAAGCTCTCCGGCTCAGACA	0.547													50	36					0	0	1	0	0	T	15198440	C	T	15198440	2	4	5	1	0	0	0	0	0	0	0	1	11005	639	23	1		1	OR1I1	19	15198440	Silent	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	4027666	15198440	43930543	57	328										
SNRPA	6626	broad.mit.edu	37	chr19	41265493	41265493	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gggagccacccccgtggtggGggctgtccaggggcctgtcc	18	14	0	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr19:41265493G>A	ENST00000243563.3	+	3	954	c.404G>A	c.(403-405)gGg>gAg	p.G135E	SNRPA_ENST00000599570.1_3'UTR	NM_004596.4	NP_004587.1	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	135						nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CCCGTGGTGGGGGCTGTCCAG	0.682													31	25					0	0	1	0	0	A	41265493	G	A	41265493	3	1	5	1	0	0	0	0	1	0	0	0	14912	1232	43	3	414	3	SNRPA	19	41265493	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	26067053	41265493	17863490	58	329										
SYMPK	8189	broad.mit.edu	37	chr19	46329516	46329516	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	cagctccaaacagcacagacGgtgggttggggtgcaccagg	15	11	0	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr19:46329516G>A	ENST00000245934.7	-	17	2541	c.2297C>T	c.(2296-2298)cCg>cTg	p.P766L		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	766					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CAGCACAGACGGTGGGTTGGG	0.572													6	17					0	0	1	0	0	A	46329516	G	A	46329516	3	1	5	1	0	0	0	0	1	0	0	0	15495	1116	39	1	1571	1	SYMPK	19	46329516	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	5064023	46329516	12799467	59	330										
MZF1	7593	broad.mit.edu	37	chr19	59074376	59074376	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gctcttccaggcgcgcgctgCgcacgaagccctggccacag	13	17	1	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr19:59074376C>A	ENST00000215057.2	-	6	1828	c.1268G>T	c.(1267-1269)cGc>cTc	p.R423L	MZF1_ENST00000599369.1_Missense_Mutation_p.R423L|AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000594234.1_3'UTR|AC016629.8_ENST00000600726.1_RNA|AC016629.8_ENST00000600534.1_RNA	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	423					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GCGCGCGCTGCGCACGAAGCC	0.687													18	48					1.01871e-10	1.15537e-10	1	1	0	A	59074376	C	A	59074376	3	1	5	1	0	0	0	0	1	0	0	0	10155	768	27	5	940	5	MZF1	19	59074376	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	12744860	59074376	54607	60	331										
MZF1	7593	broad.mit.edu	37	chr19	59074528	59074528	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gtgtggatcttctggtgcctCagcaggttgctgcgttggct	15	9	3	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr19:59074528C>T	ENST00000215057.2	-	6	1676	c.1116G>A	c.(1114-1116)ctG>ctA	p.L372L	MZF1_ENST00000599369.1_Silent_p.L372L|AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000594234.1_Silent_p.*291*|AC016629.8_ENST00000600726.1_RNA|AC016629.8_ENST00000600534.1_RNA	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	372					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TCTGGTGCCTCAGCAGGTTGC	0.687													22	43					0	0	1	0	0	T	59074528	C	T	59074528	2	4	5	1	0	0	0	0	0	0	0	1	10155	813	29	3		3	MZF1	19	59074528	Silent	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	152	59074528	54455	61	332										
ARFRP1	10139	broad.mit.edu	37	chr20	62331872	62331872	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	catccactcgatgccctcgcGcacccctttgctgtgaagac	8	17	0	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr20:62331872G>A	ENST00000359715.4	-	7	1095	c.529C>T	c.(529-531)Cgc>Tgc	p.R177C	ARFRP1_ENST00000485858.1_5'UTR|ARFRP1_ENST00000324228.2_Missense_Mutation_p.R177C|ARFRP1_ENST00000440854.1_3'UTR			Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	177					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			ATGCCCTCGCGCACCCCTTTG	0.697													12	184					0	0	1	0	0	A	62331872	G	A	62331872	3	1	5	1	0	0	0	0	1	0	0	0	853	1087	38	1	80	1	ARFRP1	20	62331872	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08		62331872	693648	62	333										
BAGE2	85319	broad.mit.edu	37	chr21	11061894	11061894	+	RNA	DEL	G	G	-													0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	accaaaattctaaaggaaaaGttatgtatatatctaataat					rs56157850		TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr21:11061894delG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAAGGAAAAGTTATGTATAT	0.318													5	5	---	---	---	---						-	11061894	G	-	11061894	6	5	5	0	1	1	0	1	0	0	0	0	1290	1044	36	0		0	BAGE2	21	11061894	RNA	DEL	G	TCGA-N5-A4RJ-01A-11D-A28R-08		11061894	37068001	63	334										
GAB4	128954	broad.mit.edu	37	chr22	17488843	17488843	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ccactcacaaagagcctcagCttcttctcggggggcgactt	10	14	4	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr22:17488843C>T	ENST00000400588.1	-	1	269	c.162G>A	c.(160-162)aaG>aaA	p.K54K	GAB4_ENST00000523144.1_5'UTR	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	54	PH.									breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AGAGCCTCAGCTTCTTCTCGG	0.697													8	13					0	0	1	0	0	T	17488843	C	T	17488843	2	4	5	1	0	0	0	0	0	0	0	1	6185	796	28	3		3	GAB4	22	17488843	Silent	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08		17488843	33815723	64	335										
NEFH	4744	broad.mit.edu	37	chr22	29879422	29879422	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	acagacgctatgcgctcagcGcaggaggagataactgagta	13	9	1	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chr22:29879422G>A	ENST00000310624.6	+	2	975	c.942G>A	c.(940-942)gcG>gcA	p.A314A		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	314	Coil 2B.|Rod.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						TGCGCTCAGCGCAGGAGGAGA	0.612													49	152					0	0	1	0	0	A	29879422	G	A	29879422	2	1	5	1	0	0	0	0	0	0	0	1	10360	1074	38	1		1	NEFH	22	29879422	Silent	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	12390579	29879422	21425144	65	336										
TAF1	6872	broad.mit.edu	37	chrX	70607151	70607151	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tcgtgctccaatttatcttcAtaagatgccagaaactgatt	6	9	2	3			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chrX:70607151A>G	ENST00000449580.1	+	15	2315	c.2264A>G	c.(2263-2265)cAt>cGt	p.H755R	TAF1_ENST00000276072.3_Missense_Mutation_p.H776R|TAF1_ENST00000423759.1_Missense_Mutation_p.H776R|TAF1_ENST00000373790.4_Missense_Mutation_p.H755R			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	755					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				ATTTATCTTCATAAGATGCCA	0.373													67	13					0	0	1	0	0	G	70607151	A	G	70607151	3	3	5	1	0	0	0	0	1	0	0	0	15569	217	8	4	2385	4	TAF1	23	70607151	Missense_Mutation	SNP	A	TCGA-N5-A4RJ-01A-11D-A28R-08		70607151	84663409	66	337										
MAGEE2	139599	broad.mit.edu	37	chrX	75004287	75004287	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	tcaacttttagcagcaagtcCcaaatggaggcctctcttgc	8	12	2	0			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chrX:75004287C>A	ENST00000373359.2	-	1	792	c.600G>T	c.(598-600)tgG>tgT	p.W200C		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	200	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCAGCAAGTCCCAAATGGAGG	0.512													18	26					3.41278e-10	3.82396e-10	1	1	0	A	75004287	C	A	75004287	3	1	5	1	0	0	0	0	1	0	0	0	9235	624	22	5	975	5	MAGEE2	23	75004287	Missense_Mutation	SNP	C	TCGA-N5-A4RJ-01A-11D-A28R-08	4397136	75004287	80266273	67	338										
GPRASP1	9737	broad.mit.edu	37	chrX	101911930	101911930	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	ggccatttgcaggtccacgtGttcagttgaacaggagcctg	13	10	1	1			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chrX:101911930G>T	ENST00000537097.1	+	6	3902	c.3089G>T	c.(3088-3090)tGt>tTt	p.C1030F	GPRASP1_ENST00000415986.1_Missense_Mutation_p.C1030F|GPRASP1_ENST00000444152.1_Missense_Mutation_p.C1030F|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Missense_Mutation_p.C1030F	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	1030	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AGGTCCACGTGTTCAGTTGAA	0.562													4	131					1	1	1	1	0	T	101911930	G	T	101911930	3	4	5	1	0	0	0	0	1	0	0	0	6762	1377	48	5	3091	5	GPRASP1	23	101911930	Missense_Mutation	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	26907643	101911930	53358630	68	339										
CDR1	1038	broad.mit.edu	37	chrX	139865785	139865785	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0289855072463768	2	1	0.375252525252525	1.20616883116883	0.222188995215311	1	1	0	gtcttccagaaagaaatccaGgtcttccagtcaatcagtgt	8	10	4	2			TCGA-N5-A4RJ-01A-11D-A28R-08	TCGA-N5-A4RJ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39f3072d-c24a-4583-95bc-4967588e6d82	623428f9-997a-484d-98e4-f6ef172d75a3	g.chrX:139865785G>A	ENST00000370532.2	-	1	938	c.747C>T	c.(745-747)acC>acT	p.T249T		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	249										breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				AAGAAATCCAGGTCTTCCAGT	0.418													96	12					0	0	1	0	0	A	139865785	G	A	139865785	2	1	5	1	0	0	0	0	0	0	0	1	3193	987	35	3		3	CDR1	23	139865785	Silent	SNP	G	TCGA-N5-A4RJ-01A-11D-A28R-08	37953855	139865785	15404775	69	340										
CPSF3L	54973	broad.mit.edu	37	chr1	1248278	1248278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cagctgcatgatgcccttggCgtccgcgtgtgcgctgaatg	14	12	0	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:1248278C>T	ENST00000540437.1	-	14	1656	c.1201G>A	c.(1201-1203)Gcc>Acc	p.A401T	CPSF3L_ENST00000411962.1_Missense_Mutation_p.A297T|CPSF3L_ENST00000462432.1_5'UTR|CPSF3L_ENST00000450926.2_Missense_Mutation_p.A373T|CPSF3L_ENST00000435064.1_Missense_Mutation_p.A395T|CPSF3L_ENST00000419704.1_Missense_Mutation_p.A294T|CPSF3L_ENST00000545578.1_Missense_Mutation_p.A366T|CPSF3L_ENST00000421495.2_Missense_Mutation_p.A137T	NM_001256456.1	NP_001243385.1	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor 3-like	395						Golgi apparatus|nucleus	hydrolase activity			endometrium(4)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(3)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		ATGCCCTTGGCGTCCGCGTGT	0.617													50	51					0	0	1	0	0	T	1248278	C	T	1248278	3	4	6	1	0	0	0	0	1	0	0	0	3850	768	27	1	643	1	CPSF3L	1	1248278	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		1248278	248002343	1	341										
KCNAB2	8514	broad.mit.edu	37	chr1	6149094	6149094	+	Frame_Shift_Del	DEL	G	G	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gacggagcggggcctgtccaGgaagcacataatcgaaggtg							TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:6149094delG	ENST00000164247.1	+	9	962	c.398delG	c.(397-399)agfs	p.R133fs	KCNAB2_ENST00000378111.1_Intron|KCNAB2_ENST00000378092.1_Frame_Shift_Del_p.R119fs|KCNAB2_ENST00000458166.2_Frame_Shift_Del_p.R66fs|KCNAB2_ENST00000378083.3_Frame_Shift_Del_p.R166fs|KCNAB2_ENST00000378087.3_Intron|KCNAB2_ENST00000378097.1_Frame_Shift_Del_p.R133fs|KCNAB2_ENST00000352527.1_Frame_Shift_Del_p.R119fs|KCNAB2_ENST00000341524.1_Frame_Shift_Del_p.R133fs|KCNAB2_ENST00000602612.1_Frame_Shift_Del_p.R133fs	NM_001199860.1	NP_001186789.1	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 2	133						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			large_intestine(1)|lung(4)|skin(3)	8	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCTGTCCAGGAAGCACATA	0.632													2	4	---	---	---	---						-	6149094	G	-	6149094	7	5	6	1	0	1	0	1	0	0	0	0	8053	1000	35	0	428	0	KCNAB2	1	6149094	Frame_Shift_Del	DEL	G	TCGA-N5-A4RM-01A-11D-A28R-08	4900816	6149094	243101527	2	342										
SPEN	23013	broad.mit.edu	37	chr1	16202965	16202978	+	Frame_Shift_Del	DEL	ACCCGGGAGGTACG	ACCCGGGAGGTACG	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	atatctacagggatgatattAcccgggaggtacgaggcaga					rs146447271		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:16202965_16202978delACCCGGGAGGTACG	ENST00000375759.3	+	3	877_890	c.673_686delACCCGGGAGGTACG	c.(673-687)afs	p.TREVR225fs	SPEN_ENST00000471538.1_3'UTR	NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	225	Arg-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GGATGATATTACCCGGGAGGTACGAGGCAGAAGG	0.528													46	105	---	---	---	---						-	16202978	ACCCGGGAGGTACG	-	16202965	7	5	6	1	0	1	0	1	0	0	0	0	15093	391	14	0	683	0	SPEN	1	16202965	Frame_Shift_Del	DEL	ACCCGGGAGGTACG	TCGA-N5-A4RM-01A-11D-A28R-08	10053871	16202965	233047656	3	343										
TIE1	7075	broad.mit.edu	37	chr1	43772665	43772665	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ttctttcggctcatcgtgcgGggtcagaggcagagggcaga	16	9	3	3	rs34084603	byFrequency	TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:43772665G>T	ENST00000372476.3	+	4	718	c.640_splice	c.e4+1	p.R213_splice	TIE1_ENST00000538015.1_Splice_Site_p.R213_splice|TIE1_ENST00000441333.2_Splice_Site_p.R213_splice	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	213					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCATCGTGCGGGGTCAGAGGC	0.637													5	142					0.00116845	0.00122356	1	1	0	T	43772665	G	T	43772665	5	4	6	1	0	0	0	0	0	0	1	0	15952	1246	43	5	653	5	TIE1	1	43772665	Splice_Site	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	27569700	43772665	205477956	4	344										
ATP8B2	57198	broad.mit.edu	37	chr1	154318722	154318722	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cacaggatgtccccgagcagCggagcatggagtaccctaag	13	12	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:154318722C>T	ENST00000368489.3	+	25	2893	c.2893C>T	c.(2893-2895)Cgg>Tgg	p.R965W		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	951					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCCCGAGCAGCGGAGCATGGA	0.577													101	105					0	0	1	0	0	T	154318722	C	T	154318722	3	4	6	1	0	0	0	0	1	0	0	0	1193	759	27	1	3121	1	ATP8B2	1	154318722	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	110546057	154318722	94931899	5	345										
RAB25	57111	broad.mit.edu	37	chr1	156039516	156039516	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cctggactctaccaatgttgAgctagcctttgagactgtcc	9	12	1	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:156039516A>G	ENST00000361084.5	+	4	729	c.488A>G	c.(487-489)gAg>gGg	p.E163G	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	163					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					ACCAATGTTGAGCTAGCCTTT	0.498													11	470					0	0	1	0	0	G	156039516	A	G	156039516	3	3	6	1	0	0	0	0	1	0	0	0	12963	304	11	4	502	4	RAB25	1	156039516	Missense_Mutation	SNP	A	TCGA-N5-A4RM-01A-11D-A28R-08	1720794	156039516	93211105	6	346										
FCRL3	115352	broad.mit.edu	37	chr1	157660318	157660318	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ggtgaggacggggcgagacaCcggaactgagggaggaaaaa	19	6	0	3	rs143813895		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:157660318C>G	ENST00000368184.3	-	9	1708	c.1417G>C	c.(1417-1419)Gtg>Ctg	p.V473L	FCRL3_ENST00000368186.5_Missense_Mutation_p.V473L|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	473						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GGGCGAGACACCGGAACTGAG	0.537													10	113					0	0	1	0	0	G	157660318	C	G	157660318	3	3	6	1	0	0	0	0	1	0	0	0	5828	507	18	5	815	5	FCRL3	1	157660318	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	1620802	157660318	91590303	7	347										
IFI16	3428	broad.mit.edu	37	chr1	159002348	159002348	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aaacccgagaaacaatgaccCcaagagcatgaagctacccc	7	14	0	4			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:159002348C>T	ENST00000295809.7	+	7	1451	c.1196C>T	c.(1195-1197)cCc>cTc	p.P399L	IFI16_ENST00000430894.2_Missense_Mutation_p.P347L|IFI16_ENST00000448393.2_Missense_Mutation_p.P399L|IFI16_ENST00000368131.4_Missense_Mutation_p.P399L|IFI16_ENST00000340979.6_Missense_Mutation_p.P399L|IFI16_ENST00000368132.3_Missense_Mutation_p.P399L|IFI16_ENST00000359709.3_Missense_Mutation_p.P343L			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	399					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					AACAATGACCCCAAGAGCATG	0.428													31	40					0	0	1	0	0	T	159002348	C	T	159002348	3	4	6	1	0	0	0	0	1	0	0	0	7554	623	22	3	1218	3	IFI16	1	159002348	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	1342030	159002348	90248273	8	348										
USH2A	7399	broad.mit.edu	37	chr1	215823955	215823955	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	actgtctcagccccatgggcGctgctggagaacagcctgta	12	13	1	1	rs147037435	byFrequency	TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr1:215823955G>C	ENST00000366943.2	-	65	14708	c.14322C>G	c.(14320-14322)agC>agG	p.S4774R	USH2A_ENST00000307340.3_Missense_Mutation_p.S4774R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4774	Fibronectin type-III 33.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCCATGGGCGCTGCTGGAGA	0.483										HNSCC(13;0.011)			5	155					0	0	1	0	0	C	215823955	G	C	215823955	3	2	6	1	0	0	0	0	1	0	0	0	17095	1078	38	5	1318	5	USH2A	1	215823955	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	56821607	215823955	33426666	9	349										
TSSC1	7260	broad.mit.edu	37	chr2	3341870	3341870	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tcacccgcttgatggaggagGacatttttatttataatgtt	9	6	1	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr2:3341870G>T	ENST00000398659.4	-	3	317	c.177C>A	c.(175-177)gtC>gtA	p.V59V	TSSC1_ENST00000382125.4_Silent_p.V59V|TSSC1_ENST00000443925.2_Silent_p.V59V			Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	59							protein binding			breast(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	18	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		GATGGAGGAGGACATTTTTAT	0.413													38	1					3.93418e-24	4.502e-24	1	1	0	T	3341870	G	T	3341870	2	4	6	1	0	0	0	0	0	0	0	1	16726	1161	41	2		2	TSSC1	2	3341870	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		3341870	239857503	10	350										
ZFP36L2	678	broad.mit.edu	37	chr2	43452192	43452192	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gctgtggtgcaacttgggccGcggctcccgcgggaagccca	16	14	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr2:43452192G>A	ENST00000282388.3	-	2	1044	c.751C>T	c.(751-753)Cgg>Tgg	p.R251W	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	251					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				AACTTGGGCCGCGGCTCCCGC	0.761													29	22					0	0	1	0	0	A	43452192	G	A	43452192	3	1	6	1	0	0	0	0	1	0	0	0	17704	1086	38	1	737	1	ZFP36L2	2	43452192	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	40110322	43452192	199747181	11	351										
LCT	3938	broad.mit.edu	37	chr2	136575373	136575373	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ccctcagtggtgttcaggggCctgcgtggatcccagatgct	14	12	2	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr2:136575373C>T	ENST00000264162.2	-	6	1255	c.1245G>A	c.(1243-1245)agG>agA	p.R415R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	415	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGTTCAGGGGCCTGCGTGGAT	0.652													61	94					0	0	1	0	0	T	136575373	C	T	136575373	2	4	6	1	0	0	0	0	0	0	0	1	8731	738	26	3		3	LCT	2	136575373	Silent	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	93123181	136575373	106624000	12	352										
SCN2A	6326	broad.mit.edu	37	chr2	166165867	166165867	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aaccccctattacagatatgTgacagagtttgtggacctgg	10	9	0	3			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr2:166165867T>A	ENST00000375437.2	+	6	901	c.611T>A	c.(610-612)gTg>gAg	p.V204E	SCN2A_ENST00000357398.3_Intron|SCN2A_ENST00000283256.6_Missense_Mutation_p.V204E|SCN2A_ENST00000375427.2_Intron	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	204					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TACAGATATGTGACAGAGTTT	0.428													35	22					0	0	1	0	0	A	166165867	T	A	166165867	3	1	6	1	0	0	0	0	1	0	0	0	13969	1696	59	4	725	4	SCN2A	2	166165867	Missense_Mutation	SNP	T	TCGA-N5-A4RM-01A-11D-A28R-08	29590494	166165867	77033506	13	353										
LYZL4	131375	broad.mit.edu	37	chr3	42448441	42448441	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tagccctcacgtgtgttctcGtagatggccatggggttgaa	13	9	2	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr3:42448441G>A	ENST00000287748.3	-	3	464	c.189C>T	c.(187-189)taC>taT	p.Y63Y	LYZL4_ENST00000441172.1_Silent_p.Y63Y|LYZL4_ENST00000470991.1_5'UTR	NM_144634.2	NP_653235.1	Q96KX0	LYZL4_HUMAN	lysozyme-like 4	63					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|endometrium(1)|lung(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.222)		GTGTGTTCTCGTAGATGGCCA	0.552													34	56					0	0	1	0	0	A	42448441	G	A	42448441	2	1	6	1	0	0	0	0	0	0	0	1	9178	1140	40	1		1	LYZL4	3	42448441	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		42448441	155573989	14	354										
GLYCTK	132158	broad.mit.edu	37	chr3	52324395	52324395	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aggtcctgccccgcttggccCgagcccccttgcatccactc	9	20	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr3:52324395C>T	ENST00000354773.4	+	2	133	c.37C>T	c.(37-39)Cga>Tga	p.R13*	GLYCTK_ENST00000477382.1_Nonsense_Mutation_p.R13*|GLYCTK_ENST00000461183.1_Intron|GLYCTK_ENST00000436784.2_Nonsense_Mutation_p.R13*|GLYCTK_ENST00000473032.1_Nonsense_Mutation_p.R13*|GLYCTK_ENST00000305690.8_Nonsense_Mutation_p.R13*|GLYCTK_ENST00000471180.1_Intron|GLYCTK-AS1_ENST00000493616.1_RNA	NM_001144951.1	NP_001138423.1	Q8IVS8	GLCTK_HUMAN	glycerate kinase	13					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		CCGCTTGGCCCGAGCCCCCTT	0.657													28	4					0	0	1	0	0	T	52324395	C	T	52324395	4	4	6	1	0	0	0	0	0	1	0	0	6523	644	23	1	39	1	GLYCTK	3	52324395	Nonsense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	9875954	52324395	145698035	15	355										
TRA2B	6434	broad.mit.edu	37	chr3	185643403	185643403	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aatgccttcgggagcttcttCtggatctagacctgcaagac	10	11	3	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr3:185643403C>G	ENST00000453386.2	-	3	457	c.182G>C	c.(181-183)aGa>aCa	p.R61T	TRA2B_ENST00000382191.4_5'UTR	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	61	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						GGAGCTTCTTCTGGATCTAGA	0.458													11	67					0	0	1	0	0	G	185643403	C	G	185643403	3	3	6	1	0	0	0	0	1	0	0	0	16494	913	32	2	712	2	TRA2B	3	185643403	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	133319008	185643403	12379027	16	356										
SORCS2	57537	broad.mit.edu	37	chr4	7725547	7725547	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	agagccccggcatctaccgcGtgtccgtcagggcagagaac	13	14	2	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr4:7725547G>A	ENST00000507866.2	+	19	2657	c.2548G>A	c.(2548-2550)Gtg>Atg	p.V850M	SORCS2_ENST00000329016.9_Missense_Mutation_p.V678M	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	850	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						CATCTACCGCGTGTCCGTCAG	0.602													81	73					0	0	1	0	0	A	7725547	G	A	7725547	3	1	6	1	0	0	0	0	1	0	0	0	14984	1145	40	1	2622	1	SORCS2	4	7725547	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		7725547	183428729	17	357										
SGMS2	166929	broad.mit.edu	37	chr4	108816771	108816771	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aaatcaacccagtgatcctaCgaacacttatgcaagacccg	6	13	1	2	rs17038204	byFrequency	TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr4:108816771C>A	ENST00000394684.4	+	3	619	c.62C>A	c.(61-63)aCg>aAg	p.T21K	RP11-286E11.1_ENST00000499098.1_RNA|SGMS2_ENST00000394686.3_Missense_Mutation_p.T21K|SGMS2_ENST00000359079.4_Missense_Mutation_p.T21K|RP11-286E11.1_ENST00000513071.1_RNA	NM_001136258.1	NP_001129730.1	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	21			T -> M (in dbSNP:rs17038204).		sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|liver(2)|lung(6)|prostate(1)	20				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	AGTGATCCTACGAACACTTAT	0.423													11	125					3.07112e-06	3.3421e-06	1	1	0	A	108816771	C	A	108816771	3	1	6	1	0	0	0	0	1	0	0	0	14268	536	19	5	64	5	SGMS2	4	108816771	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	101091224	108816771	82337505	18	358										
HCN1	348980	broad.mit.edu	37	chr5	45262055	45262055	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	agcaaatcgtggcttttctgCgtctgggtctgtgtttaaga	12	7	3	1	rs56377228		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr5:45262055C>A	ENST00000303230.4	-	8	2698	c.2641G>T	c.(2641-2643)Gca>Tca	p.A881S		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	881						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GGCTTTTCTGCGTCTGGGTCT	0.473													11	164					0.000151284	0.000161467	1	1	0	A	45262055	C	A	45262055	3	1	6	1	0	0	0	0	1	0	0	0	7036	768	27	5	35	5	HCN1	5	45262055	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		45262055	135653205	19	359										
ARSB	411	broad.mit.edu	37	chr5	78280984	78280984	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gcccggcggcgccaacaacaGcagcagcagcagcgggagga	16	14	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr5:78280984G>A	ENST00000264914.4	-	1	624	c.88C>T	c.(88-90)Ctg>Ttg	p.L30L	ARSB_ENST00000565165.1_Silent_p.L30L|ARSB_ENST00000396151.3_Silent_p.L30L	NM_000046.3	NP_000037.2	P15848	ARSB_HUMAN	arylsulfatase B	30					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		gccAACAACAGCAGCAGCAGC	0.751													4	22					0	0	1	0	0	A	78280984	G	A	78280984	2	1	6	1	0	0	0	0	0	0	0	1	987	962	34	3		3	ARSB	5	78280984	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	33018929	78280984	102634276	20	360										
SRP19	6728	broad.mit.edu	37	chr5	112198213	112198213	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tgtctatggcaggtttatttGtatctatcctgcttatttaa	7	6	2	0	rs77541650		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr5:112198213G>T	ENST00000505459.1	+	2	205	c.50G>T	c.(49-51)tGt>tTt	p.C17F	SRP19_ENST00000515463.1_Intron|SRP19_ENST00000512790.1_3'UTR|SRP19_ENST00000282999.3_Missense_Mutation_p.C17F|CTC-554D6.1_ENST00000520401.1_Missense_Mutation_p.L88F	NM_001204193.1|NM_003135.2	NP_001191122.1|NP_003126.1	P09132	SRP19_HUMAN	signal recognition particle 19kDa	17					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding			breast(1)|cervix(1)|large_intestine(1)	3		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		AGGTTTATTTGTATCTATCCT	0.458													4	35					0.00116845	0.00122356	1	1	0	T	112198213	G	T	112198213	3	4	6	1	0	0	0	0	1	0	0	0	15209	1377	48	5	56	5	SRP19	5	112198213	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	33917229	112198213	68717047	21	361										
PCDHGA10	0	broad.mit.edu	37	chr5	140793312	140793312	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ctaagagttcagagccgtgcCaatggcgtcaagtacccgga	12	11	2	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr5:140793312C>T	ENST00000398610.2	+	1	570	c.570C>T	c.(568-570)gcC>gcT	p.A190A	PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGCCGTGCCAATGGCGTCA	0.597													19	35					0	0	1	0	0	T	140793312	C	T	140793312	2	4	6	1	0	0	0	0	0	0	0	1	11597	581	21	3		3	PCDHGA10	5	140793312	Silent	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	28595099	140793312	40121948	22	362										
ARAP3	64411	broad.mit.edu	37	chr5	141044588	141044588	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tgtgccgcccccaccagccgCgcccccaatggctgcgttcc	10	21	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr5:141044588C>T	ENST00000239440.4	-	19	2766	c.2701G>A	c.(2701-2703)Gcg>Acg	p.A901T	ARAP3_ENST00000508305.1_Missense_Mutation_p.A803T|ARAP3_ENST00000513878.1_Missense_Mutation_p.A563T|ARAP3_ENST00000512390.1_5'UTR	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	901					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCACCAGCCGCGCCCCCAATG	0.637											OREG0016871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	22					0	0	1	0	0	T	141044588	C	T	141044588	3	4	6	1	0	0	0	0	1	0	0	0	837	768	27	1	1993	1	ARAP3	5	141044588	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	251276	141044588	39870672	23	363										
PDGFRB	5159	broad.mit.edu	37	chr5	149500558	149500558	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gagcacgttcctagccgccaGgtctctgtggacgcactggg	14	13	1	0	rs67186817		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr5:149500558G>C	ENST00000261799.4	-	18	2948	c.2479C>G	c.(2479-2481)Ctg>Gtg	p.L827V		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	827	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTAGCCGCCAGGTCTCTGTGG	0.542			T	"ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"	"MPD, AML, CMML, CML"								35	46					0	0	1	0	0	C	149500558	G	C	149500558	3	2	6	1	0	0	0	0	1	0	0	0	11708	991	35	5	865	5	PDGFRB	5	149500558	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	8455970	149500558	31414702	24	364										
LPA	4018	broad.mit.edu	37	chr6	160999636	160999636	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cgattctgtcactggacatcGtgtcaggttgcagtactccc	10	12	3	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr6:160999636G>A	ENST00000447678.1	-	28	4510	c.4390C>T	c.(4390-4392)Cga>Tga	p.R1464*	LPA_ENST00000316300.5_Nonsense_Mutation_p.R1464*	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3972	Kringle 13.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ACTGGACATCGTGTCAGGTTG	0.527													78	86					0	0	1	0	0	A	160999636	G	A	160999636	4	1	6	1	0	0	0	0	0	1	0	0	8947	1153	40	1	1784	1	LPA	6	160999636	Nonsense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		160999636	10115431	25	365										
RNF216	54476	broad.mit.edu	37	chr7	5752492	5752492	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ccttccatgcagctgagctcCaactagaaaaaggcgaaaag	9	11	0	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr7:5752492C>A	ENST00000425013.2	-	12	1889	c.1665G>T	c.(1663-1665)ttG>ttT	p.L555F	RNF216_ENST00000389902.3_Missense_Mutation_p.L612F	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	555					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		AGCTGAGCTCCAACTAGAAAA	0.423													6	54					0.217242	0.217242	1	1	0	A	5752492	C	A	5752492	3	1	6	1	0	0	0	0	1	0	0	0	13531	593	21	5	959	5	RNF216	7	5752492	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		5752492	153386171	26	366										
RNF216	54476	broad.mit.edu	37	chr7	5760801	5760801	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cctcttttctatttttatgtCacctagaagatatacgacaa	4	9	3	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr7:5760801C>A	ENST00000425013.2	-	9	1560	c.1336G>T	c.(1336-1338)Gac>Tac	p.D446Y	RNF216_ENST00000389902.3_Missense_Mutation_p.D503Y	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	446					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		ATTTTTATGTCACCTAGAAGA	0.458													4	62					0.00909568	0.00926257	1	1	0	A	5760801	C	A	5760801	3	1	6	1	0	0	0	0	1	0	0	0	13531	826	29	2	1300	2	RNF216	7	5760801	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	8309	5760801	153377862	27	367										
ABCA13	154664	broad.mit.edu	37	chr7	48494835	48494835	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ggccaccgagtaccctccccTcagactcacacctggacatt	7	18	2	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr7:48494835T>G	ENST00000435803.1	+	43	12791	c.12767T>G	c.(12766-12768)cTc>cGc	p.L4256R	ABCA13_ENST00000544596.1_Missense_Mutation_p.L16R	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4256					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TACCCTCCCCTCAGACTCACA	0.542													4	35					0	0	1	0	0	G	48494835	T	G	48494835	3	3	6	1	0	0	0	0	1	0	0	0	31	1551	54	4	12766	4	ABCA13	7	48494835	Missense_Mutation	SNP	T	TCGA-N5-A4RM-01A-11D-A28R-08	42734034	48494835	110643828	28	368										
DLC1	10395	broad.mit.edu	37	chr8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ccgactggctgctgctgctgCtggtctgcgtggagttggaa	16	10	1	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr8:12957624C>G	ENST00000276297.4	-	9	2631	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	DLC1_ENST00000358919.2_Missense_Mutation_p.S304T|DLC1_ENST00000512044.2_Missense_Mutation_p.S338T|DLC1_ENST00000520226.1_Missense_Mutation_p.S230T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCTGCTGCTGGTCTGCGT	0.627													5	96					0	0	1	0	0	G	12957624	C	G	12957624	3	3	6	1	0	0	0	0	1	0	0	0	4578	797	28	5	2404	5	DLC1	8	12957624	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		12957624	133406398	29	369										
ADRA1A	148	broad.mit.edu	37	chr8	26627888	26627888	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aaaaatttccattcacaaacGccatccgtcttggagatcct	5	12	2	1	rs143947423		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr8:26627888G>A	ENST00000380573.3	-	3	2202	c.1179C>T	c.(1177-1179)ggC>ggT	p.G393G	ADRA1A_ENST00000380587.1_Intron|ADRA1A_ENST00000519229.1_Silent_p.G393G|ADRA1A_ENST00000380581.2_Intron|ADRA1A_ENST00000380582.3_Silent_p.G393G|ADRA1A_ENST00000354550.4_Silent_p.G393G|ADRA1A_ENST00000276393.4_Silent_p.G393G|ADRA1A_ENST00000380586.1_Silent_p.G393G			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	393					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	ATTCACAAACGCCATCCGTCT	0.552													104	102					0	0	1	0	0	A	26627888	G	A	26627888	2	1	6	1	0	0	0	0	0	0	0	1	333	1074	38	1		1	ADRA1A	8	26627888	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	13670264	26627888	119736134	30	370										
CSPP1	79848	broad.mit.edu	37	chr8	68084769	68084769	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cttttcagaatgttcatgatTttaatgagctgaaagataga	8	4	2	6			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr8:68084769T>G	ENST00000262210.5	+	23	2963	c.2932T>G	c.(2932-2934)Ttt>Gtt	p.F978V	CSPP1_ENST00000412460.1_Missense_Mutation_p.F633V|CSPP1_ENST00000521168.1_3'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	1013						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TGTTCATGATTTTAATGAGCT	0.388													12	27					0	0	1	0	0	G	68084769	T	G	68084769	3	3	6	1	0	0	0	0	1	0	0	0	3987	1841	64	4	3135	4	CSPP1	8	68084769	Missense_Mutation	SNP	T	TCGA-N5-A4RM-01A-11D-A28R-08	41456881	68084769	78279253	31	371										
VPS28	51160	broad.mit.edu	37	chr8	145649436	145649436	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	acacccaccactggctgaccGtctggcggccctcaaagtcg	10	17	2	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr8:145649436G>A	ENST00000377348.2	-	9	625	c.536C>T	c.(535-537)aCg>aTg	p.T179M	VPS28_ENST00000526054.1_Missense_Mutation_p.T179M|VPS28_ENST00000529182.1_Missense_Mutation_p.T179M|VPS28_ENST00000292510.4_Missense_Mutation_p.T179M	NM_183057.1	NP_898880.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	179	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTGGCTGACCGTCTGGCGGCC	0.692													10	291					0	0	1	0	0	A	145649436	G	A	145649436	3	1	6	1	0	0	0	0	1	0	0	0	17258	1145	40	1	251	1	VPS28	8	145649436	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	77564667	145649436	714586	32	372										
FRMPD2	143162	broad.mit.edu	37	chr10	49395266	49395266	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ctctgaacaggtggtccagaGagagagtcccaggtcattgg	14	9	2	3			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr10:49395266G>A	ENST00000374201.3	-	17	2537	c.2235C>T	c.(2233-2235)ctC>ctT	p.L745L	FRMPD2_ENST00000407470.4_Silent_p.L713L|FRMPD2_ENST00000305531.3_Silent_p.L720L	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	745					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GTGGTCCAGAGAGAGAGTCCC	0.562													14	35					0	0	1	0	0	A	49395266	G	A	49395266	2	1	6	1	0	0	0	0	0	0	0	1	6092	929	33	3		3	FRMPD2	10	49395266	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		49395266	86139481	33	373										
OGDHL	55753	broad.mit.edu	37	chr10	50959892	50959892	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cctcatggagcgcactagccGggccagcagggtccgcttct	13	15	2	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr10:50959892G>A	ENST00000374103.4	-	6	815	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W	OGDHL_ENST00000432695.1_Missense_Mutation_p.R35W|OGDHL_ENST00000419399.1_Missense_Mutation_p.R187W	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	244					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.R244R(1)		central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CGCACTAGCCGGGCCAGCAGG	0.612													95	91					0	0	1	0	0	A	50959892	G	A	50959892	3	1	6	1	0	0	0	0	1	0	0	0	10887	1115	39	1	2374	1	OGDHL	10	50959892	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	1564626	50959892	84574855	34	374										
ARID5B	84159	broad.mit.edu	37	chr10	63852608	63852608	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ctcgcttgtgatgcaaagagGaatttttacatcaccgacaa	8	9	1	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr10:63852608G>C	ENST00000279873.7	+	10	3796	c.3386G>C	c.(3385-3387)gGa>gCa	p.G1129A	ARID5B_ENST00000309334.5_Missense_Mutation_p.G886A	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1129					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					ATGCAAAGAGGAATTTTTACA	0.478													6	143					0	0	1	0	0	C	63852608	G	C	63852608	3	2	6	1	0	0	0	0	1	0	0	0	919	1174	41	2	3424	2	ARID5B	10	63852608	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	12892716	63852608	71682139	35	375										
LRIT1	26103	broad.mit.edu	37	chr10	86001097	86001097	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gccttgctgccatcacccatGatatggaggctgcagctgca	11	13	1	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr10:86001097G>C	ENST00000372105.3	-	1	120	c.99C>G	c.(97-99)atC>atG	p.I33M		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	33	LRRNT.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						CATCACCCATGATATGGAGGC	0.642													6	64					0	0	1	0	0	C	86001097	G	C	86001097	3	2	6	1	0	0	0	0	1	0	0	0	8991	1280	45	2	1788	2	LRIT1	10	86001097	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	22148489	86001097	49533650	36	376										
MUC2	4583	broad.mit.edu	37	chr11	1093292	1093292	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	atcgacacccatcaccaccaCcactacggtgaccccaaccc	4	21	1	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr11:1093292C>T	ENST00000441003.2	+	30	5138	c.5111C>T	c.(5110-5112)aCc>aTc	p.T1704I	MUC2_ENST00000361558.6_Intron|MUC2_ENST00000359061.5_Missense_Mutation_p.T1671I	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1695	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	atcaccaccaccactacggtg	0.637													4	20					0	0	1	0	0	T	1093292	C	T	1093292	3	4	6	1	0	0	0	0	1	0	0	0	10022	507	18	3	5229	3	MUC2	11	1093292	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		1093292	133913224	37	377										
OR5L2	26338	broad.mit.edu	37	chr11	55595238	55595238	+	Frame_Shift_Del	DEL	C	C	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	accacttcttctgtgatctaCcccctctcctaagtcttgct							TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr11:55595238delC	ENST00000378397.1	+	1	544	c.544delC	c.(544-546)ccfs	p.P183fs		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CTGTGATCTACCCCCTCTCCT	0.453										HNSCC(27;0.073)			119	187	---	---	---	---						-	55595238	C	-	55595238	7	5	6	1	0	1	0	1	0	0	0	0	11217	507	18	0	546	0	OR5L2	11	55595238	Frame_Shift_Del	DEL	C	TCGA-N5-A4RM-01A-11D-A28R-08	54501946	55595238	79411278	38	378										
OTUB1	55611	broad.mit.edu	37	chr11	63764986	63764986	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ccaaggtctaccttctctacCggcctggacactacgatatc	7	15	2	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr11:63764986C>T	ENST00000541478.1	+	4	941	c.481C>T	c.(481-483)Cgg>Tgg	p.R161W	OTUB1_ENST00000428192.2_Missense_Mutation_p.R262W|OTUB1_ENST00000543988.1_Missense_Mutation_p.R232W|OTUB1_ENST00000422031.2_Missense_Mutation_p.R299W|OTUB1_ENST00000535715.1_Intron|OTUB1_ENST00000543004.1_Missense_Mutation_p.R271W|OTUB1_ENST00000538426.1_Missense_Mutation_p.R262W			Q96FW1	OTUB1_HUMAN	OTU domain, ubiquitin aldehyde binding 1	262	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	6						CCTTCTCTACCGGCCTGGACA	0.617													58	109					0	0	1	0	0	T	63764986	C	T	63764986	3	4	6	1	0	0	0	0	1	0	0	0	11357	643	23	1	810	1	OTUB1	11	63764986	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	8169748	63764986	71241530	39	379										
CCDC88B	283234	broad.mit.edu	37	chr11	64112227	64112227	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gaggaggtggcacagttgagGagaaaggctgaggcccttgg	19	6	0	3			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr11:64112227G>A	ENST00000356786.5	+	14	2258	c.2214G>A	c.(2212-2214)agG>agA	p.R738R	CCDC88B_ENST00000301897.4_5'UTR|CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	738					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CACAGTTGAGGAGAAAGGCTG	0.652													4	37					0	0	1	0	0	A	64112227	G	A	64112227	2	1	6	1	0	0	0	0	0	0	0	1	2884	1165	41	3		3	CCDC88B	11	64112227	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	347241	64112227	70894289	40	380										
FDX1	2230	broad.mit.edu	37	chr11	110327746	110327746	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	atgaggagaatgacatgctcGatctggcatatggactaaca	11	7	1	3			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr11:110327746G>A	ENST00000260270.2	+	3	653	c.415G>A	c.(415-417)Gat>Aat	p.D139N		NM_004109.4	NP_004100.1	P10109	ADX_HUMAN	ferredoxin 1	139	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding			lung(2)	2		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)	TGACATGCTCGATCTGGCATA	0.383													10	80					0	0	1	0	0	A	110327746	G	A	110327746	3	1	6	1	0	0	0	0	1	0	0	0	5836	1058	37	1	425	1	FDX1	11	110327746	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	46215519	110327746	24678770	41	381										
C1RL	51279	broad.mit.edu	37	chr12	7249404	7249404	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aggacgttggggcccaggggGatgctgtgctgcagctccag	18	10	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr12:7249404G>A	ENST00000266542.4	-	6	1139	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	C1RL_ENST00000545280.1_Intron|C1RL_ENST00000544702.1_3'UTR|C1RL_ENST00000504702.2_Intron	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	349	Peptidase S1.			I -> M (in Ref. 3; BAD96522).	complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGCCCAGGGGGATGCTGTGCT	0.612													5	71					0	0	1	0	0	A	7249404	G	A	7249404	2	1	6	1	0	0	0	0	0	0	0	1	1986	1164	41	3		3	C1RL	12	7249404	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		7249404	126602491	42	382										
KRT72	140807	broad.mit.edu	37	chr12	52985408	52985408	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tgtgggactggatctgagtgAtctcctggggacggttgggg	19	6	2	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr12:52985408A>C	ENST00000293745.2	-	5	888	c.803T>G	c.(802-804)aTc>aGc	p.I268S	KRT72_ENST00000354310.4_Missense_Mutation_p.I268S|KRT72_ENST00000398066.3_Missense_Mutation_p.I80S|KRT72_ENST00000537672.2_Missense_Mutation_p.I268S	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	268	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		GATCTGAGTGATCTCCTGGGG	0.577													14	88					0	0	1	0	0	C	52985408	A	C	52985408	3	2	6	1	0	0	0	0	1	0	0	0	8527	333	12	4	752	4	KRT72	12	52985408	Missense_Mutation	SNP	A	TCGA-N5-A4RM-01A-11D-A28R-08	45736004	52985408	80866487	43	383										
OR6C2	341416	broad.mit.edu	37	chr12	55846759	55846759	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	attgcctatggaagctgcatCttcatctatatcaagccctc	6	12	4	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr12:55846759C>G	ENST00000322678.1	+	1	762	c.762C>G	c.(760-762)atC>atG	p.I254M	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_054105.1	NP_473446.1	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C, member 2	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(5)|lung(8)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	23						GAAGCTGCATCTTCATCTATA	0.423													26	69					0	0	1	0	0	G	55846759	C	G	55846759	3	3	6	1	0	0	0	0	1	0	0	0	11237	903	32	2	764	2	OR6C2	12	55846759	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	2861351	55846759	78005136	44	384										
LRP1	4035	broad.mit.edu	37	chr12	57589461	57589461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tgtacaacagcacttgtgacGaccgtgagttcatgtgccag	11	10	1	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr12:57589461G>A	ENST00000243077.3	+	53	8924	c.8458G>A	c.(8458-8460)Gac>Aac	p.D2820N		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2820	LDL-receptor class A 18.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CACTTGTGACGACCGTGAGTT	0.602													38	40					0	0	1	0	0	A	57589461	G	A	57589461	3	1	6	1	0	0	0	0	1	0	0	0	8995	1058	37	1	8668	1	LRP1	12	57589461	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	1742702	57589461	76262434	45	385										
NOC4L	79050	broad.mit.edu	37	chr12	132633385	132633385	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gtgcatgacgccatcctgccGcagctggcgcagcccacgct	12	17	0	1	rs144597773		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr12:132633385G>A	ENST00000330579.1	+	9	887	c.846G>A	c.(844-846)ccG>ccA	p.P282P	NOC4L_ENST00000535343.1_3'UTR	NM_024078.1	NP_076983.1	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog (S. cerevisiae)	282					rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|skin(2)	14	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		CCATCCTGCCGCAGCTGGCGC	0.701													19	17					0	0	1	0	0	A	132633385	G	A	132633385	2	1	6	1	0	0	0	0	0	0	0	1	10561	1074	38	1		1	NOC4L	12	132633385	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	75043924	132633385	1218510	46	386										
WASF3	10810	broad.mit.edu	37	chr13	27257060	27257060	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cgaagcggcaagagcctgcaCagccaccaatcagtgatgct	11	13	1	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr13:27257060C>T	ENST00000361042.4	+	9	1516	c.1291C>T	c.(1291-1293)Cag>Tag	p.Q431*	WASF3_ENST00000335327.5_Nonsense_Mutation_p.Q434*			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	434					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		AGAGCCTGCACAGCCACCAAT	0.612													5	135					0	0	1	0	0	T	27257060	C	T	27257060	4	4	6	1	0	0	0	0	0	1	0	0	17313	479	17	3	1326	3	WASF3	13	27257060	Nonsense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		27257060	87912818	47	387										
OR4K1	79544	broad.mit.edu	37	chr14	20404416	20404416	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gatacatatgaaatggaaatTatgaccctaacgaacagtgg	9	6	0	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr14:20404416T>C	ENST00000285600.4	+	1	650	c.591T>C	c.(589-591)atT>atC	p.I197I		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AAATGGAAATTATGACCCTAA	0.453													3	38					0	0	1	0	0	C	20404416	T	C	20404416	2	2	6	1	0	0	0	0	0	0	0	1	11114	1742	61	4		4	OR4K1	14	20404416	Silent	SNP	T	TCGA-N5-A4RM-01A-11D-A28R-08		20404416	86945124	48	388										
AHNAK2	113146	broad.mit.edu	37	chr14	105418191	105418191	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aggtccccctgcatggagggGagactcacgtcggcctccac	13	15	1	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr14:105418191G>A	ENST00000333244.5	-	7	3716	c.3597C>T	c.(3595-3597)ctC>ctT	p.L1199L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1199						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCATGGAGGGGAGACTCACGT	0.632													6	484					0	0	1	0	0	A	105418191	G	A	105418191	2	1	6	1	0	0	0	0	0	0	0	1	412	1161	41	3		3	AHNAK2	14	105418191	Silent	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	85013775	105418191	1931349	49	389										
MAN2C1	4123	broad.mit.edu	37	chr15	75654730	75654730	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gcacaaactgcccacggcacGcaaactcctggatgcgggag	12	14	0	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr15:75654730G>A	ENST00000565683.1	-	8	973	c.962C>T	c.(961-963)gCg>gTg	p.A321V	MAN2C1_ENST00000563622.1_Missense_Mutation_p.A222V|MAN2C1_ENST00000267978.5_Missense_Mutation_p.A321V|MAN2C1_ENST00000569482.1_Missense_Mutation_p.A321V	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	321					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CCCACGGCACGCAAACTCCTG	0.612													4	31					0	0	1	0	0	A	75654730	G	A	75654730	3	1	6	1	0	0	0	0	1	0	0	0	9267	1087	38	1	2236	1	MAN2C1	15	75654730	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		75654730	26876662	50	390										
GRIN2A	0	broad.mit.edu	37	chr16	9934842	9934842	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	taactttcttgccatgcttcCcattggtcaccagatagagg	8	11	2	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr16:9934842C>A	ENST00000396573.2	-	7	1757	c.1448G>T	c.(1447-1449)gGg>gTg	p.G483V	GRIN2A_ENST00000330684.3_Missense_Mutation_p.G483V|GRIN2A_ENST00000396575.2_Missense_Mutation_p.G483V|GRIN2A_ENST00000404927.2_Missense_Mutation_p.G483V|GRIN2A_ENST00000562109.1_Missense_Mutation_p.G483V|GRIN2A_ENST00000535259.1_Missense_Mutation_p.G326V	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	483					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCATGCTTCCCATTGGTCAC	0.428													37	109					5.43694e-19	6.15816e-19	1	1	0	A	9934842	C	A	9934842	3	1	6	1	0	0	0	0	1	0	0	0	6819	623	22	5	2978	5	GRIN2A	16	9934842	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		9934842	80419911	51	391										
GSG2	83903	broad.mit.edu	37	chr17	3627230	3627230	+	Translation_Start_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cctcttggcgggtgccggccAtggcggcttcgctcccggga	16	15	1	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr17:3627230A>G	ENST00000325418.4	+	1	20	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	1					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										GGTGCCGGCCATGGCGGCTTC	0.731													35	4					0	0	1	0	0	G	3627230	A	G	3627230	1	3	6	1	0	0	0	0	0	0	0	0	6862	217	8	4		4	GSG2	17	3627230	Translation_Start_Site	SNP	A	TCGA-N5-A4RM-01A-11D-A28R-08		3627230	77567980	52	392										
ITGAE	3682	broad.mit.edu	37	chr17	3638132	3638132	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ttttgcatcctcttcaactgCaggtttctggggtaattcaa	8	9	4	0	rs149392793	by1000genomes	TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr17:3638132C>T	ENST00000263087.4	-	21	2732	c.2634G>A	c.(2632-2634)ctG>ctA	p.L878L	ITGAE_ENST00000571185.1_5'UTR	NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	878					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TCTTCAACTGCAGGTTTCTGG	0.542													114	17					0	0	1	0	0	T	3638132	C	T	3638132	2	4	6	1	0	0	0	0	0	0	0	1	7928	697	25	3		3	ITGAE	17	3638132	Silent	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	10902	3638132	77557078	53	393										
TP53	7157	broad.mit.edu	37	chr17	7577550	7577550	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tgggcctccggttcatgccgCccatgcaggaactgttacac	11	14	1	0	rs28934572		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr17:7577550C>T	ENST00000420246.2	-	7	863	c.731G>A	c.(730-732)gGc>gAc	p.G244D	TP53_ENST00000269305.4_Missense_Mutation_p.G244D|TP53_ENST00000413465.2_Missense_Mutation_p.G244D|TP53_ENST00000455263.2_Missense_Mutation_p.G244D|TP53_ENST00000445888.2_Missense_Mutation_p.G244D|TP53_ENST00000359597.4_Missense_Mutation_p.G244D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	244	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934572).|G -> E (in a sporadic cancer; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|MG -> IC (in a sporadic cancer; somatic mutation).|MG -> IS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G244D(47)|p.G244V(14)|p.G244A(9)|p.0?(8)|p.?(5)|p.G151D(4)|p.G244fs*4(3)|p.G244_M246>V(3)|p.G244fs*19(1)|p.G151_M153>V(1)|p.G244fs*17(1)|p.M243fs*18(1)|p.G244E(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.G244del(1)|p.G151fs*4(1)|p.C238_M246delCNSSCMGGM(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTCATGCCGCCCATGCAGGA	0.577		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			54	2					0	0	1	0	0	T	7577550	C	T	7577550	3	4	6	1	0	0	0	0	1	0	0	0	16441	739	26	3	559	3	TP53	17	7577550	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	3939418	7577550	73617660	54	394										
DNAH17	8632	broad.mit.edu	37	chr17	76570856	76570856	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	tgatgtcgccgtaaaggagcCgggccctgtagttgtccttg	14	10	0	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr17:76570856C>T	ENST00000389840.5	-	2	408	c.284G>A	c.(283-285)cGg>cAg	p.R95Q	DNAH17_ENST00000585328.1_Missense_Mutation_p.R95Q					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTAAAGGAGCCGGGCCCTGTA	0.597													5	161					0	0	1	0	0	T	76570856	C	T	76570856	3	4	6	1	0	0	0	0	1	0	0	0	4629	652	23	1	13424	1	DNAH17	17	76570856	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	68993306	76570856	4624354	55	395										
MAST1	22983	broad.mit.edu	37	chr19	12975741	12975743	+	In_Frame_Del	DEL	CCG	CCG	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cacaactatggcatcgtgcaCcgcgacctcaagcctgacaa					rs146244031		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr19:12975741_12975743delCCG	ENST00000251472.4	+	13	1524_1526	c.1485_1487delCCG	c.(1483-1488)cac>ca	p.HR495del		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	495	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						GCATCGTGCACCGCGACCTCAAG	0.567													66	12	---	---	---	---						-	12975743	CCG	-	12975741	7	5	6	1	0	1	0	1	0	0	0	0	9373	506	18	0	1535	0	MAST1	19	12975741	In_Frame_Del	DEL	CCG	TCGA-N5-A4RM-01A-11D-A28R-08		12975741	46153242	56	396										
ZNF345	25850	broad.mit.edu	37	chr19	37367691	37367691	+	Translation_Start_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ttatattttctttcagactaTgaatcaaagttgagaccaag	6	6	3	3			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr19:37367691T>G	ENST00000529555.1	+	0	747				ZNF345_ENST00000526123.1_De_novo_Start_OutOfFrame|ZNF345_ENST00000589046.1_De_novo_Start_OutOfFrame|ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000420450.1_De_novo_Start_OutOfFrame			Q14585	ZN345_HUMAN	zinc finger protein 345						negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTCAGACTATGAATCAAAGT	0.303													21	37					0	0	1	0	0	G	37367691	T	G	37367691	1	3	6	1	0	0	0	0	0	0	0	0	17915	1479	51	4		4	ZNF345	19	37367691	Translation_Start_Site	SNP	T	TCGA-N5-A4RM-01A-11D-A28R-08	24391950	37367691	21761292	57	397										
ZNF230	7773	broad.mit.edu	37	chr19	44515243	44515243	+	Frame_Shift_Del	DEL	T	T	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cttcagatggtcctcatatcTtttgatccatcagcgaatcc							TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr19:44515243delT	ENST00000429154.2	+	5	1280	c.1052delT	c.(1051-1053)ctfs	p.L352fs		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				TCCTCATATCTTTTGATCCAT	0.428													82	196	---	---	---	---						-	44515243	T	-	44515243	7	5	6	1	0	1	0	1	0	0	0	0	17841	1609	56	0	1066	0	ZNF230	19	44515243	Frame_Shift_Del	DEL	T	TCGA-N5-A4RM-01A-11D-A28R-08	7147552	44515243	14613740	58	398										
TBC1D17	79735	broad.mit.edu	37	chr19	50384528	50384528	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cagtgccgtctccctaggtgCagagcccagctgcccccagg	12	17	1	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr19:50384528C>G	ENST00000221543.5	+	5	622	c.323C>G	c.(322-324)gCa>gGa	p.A108G	TBC1D17_ENST00000598789.1_Intron|TBC1D17_ENST00000535102.2_Missense_Mutation_p.A75G	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	108						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TCCCTAGGTGCAGAGCCCAGC	0.632													3	25					0	0	1	0	0	G	50384528	C	G	50384528	3	3	6	1	0	0	0	0	1	0	0	0	15662	710	25	5	341	5	TBC1D17	19	50384528	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	5869285	50384528	8744455	59	399										
FASTKD5	60493	broad.mit.edu	37	chr20	3128656	3128656	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	taacaatattcactaaggagCgactactcagatgctgaatg	8	8	2	2			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr20:3128656C>A	ENST00000380266.3	-	2	1382	c.1061G>T	c.(1060-1062)cGc>cTc	p.R354L	UBOX5_ENST00000348031.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	354					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						CACTAAGGAGCGACTACTCAG	0.403													10	103					2.80697e-09	3.11574e-09	1	1	0	A	3128656	C	A	3128656	3	1	6	1	0	0	0	0	1	0	0	0	5720	768	27	5	1237	5	FASTKD5	20	3128656	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		3128656	59896864	60	400										
PTPRT	11122	broad.mit.edu	37	chr20	40730876	40730876	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ttcgattcttatcatggttcCggggcaggagcccaatgctg	12	10	2	0			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr20:40730876C>T	ENST00000373198.3	-	27	3903	c.3668G>A	c.(3667-3669)cGg>cAg	p.R1223Q	PTPRT_ENST00000373193.3_Missense_Mutation_p.R1204Q|PTPRT_ENST00000373201.1_Missense_Mutation_p.R1191Q|PTPRT_ENST00000373187.1_Missense_Mutation_p.R1201Q|PTPRT_ENST00000356100.2_Missense_Mutation_p.R1210Q|PTPRT_ENST00000373184.1_Missense_Mutation_p.R1211Q|PTPRT_ENST00000373190.1_Missense_Mutation_p.R1200Q	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1201	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATCATGGTTCCGGGGCAGGAG	0.557													37	81					0	0	1	0	0	T	40730876	C	T	40730876	3	4	6	1	0	0	0	0	1	0	0	0	12863	652	23	1	747	1	PTPRT	20	40730876	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	37602220	40730876	22294644	61	401										
BCAS1	8537	broad.mit.edu	37	chr20	52612494	52612494	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	atagctgctgcctgggaatcGtcctttgcagtctccagtcc	10	13	1	0	rs146823292		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr20:52612494G>A	ENST00000434986.2	-	0	242				BCAS1_ENST00000395961.3_Silent_p.D273D|BCAS1_ENST00000371440.3_Silent_p.D273D|BCAS1_ENST00000371435.2_Silent_p.D273D			O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1							cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCTGGGAATCGTCCTTTGCAG	0.463													39	80					0	0	1	0	0	A	52612494	G	A	52612494	1	1	6	1	0	0	0	0	0	0	0	0	1348	1136	40	1		1	BCAS1	20	52612494	Translation_Start_Site	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08	11881618	52612494	10413026	62	402										
BAGE2	85319	broad.mit.edu	37	chr21	11040447	11040447	+	RNA	DEL	A	A	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gaaagactacaggtaaggatAaaagaaaactaccaaataac					rs145874834		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr21:11040447delA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGTAAGGATAAAAGAAAACT	0.343													3	4	---	---	---	---						-	11040447	A	-	11040447	6	5	6	0	1	1	0	1	0	0	0	0	1290	377	13	0		0	BAGE2	21	11040447	RNA	DEL	A	TCGA-N5-A4RM-01A-11D-A28R-08		11040447	37089448	63	403										
BAGE2	85319	broad.mit.edu	37	chr21	11064287	11064288	+	RNA	INS	-	-	A													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ctcctccctgcttccacagcINSaatctttctaaaggaataca					rs55767427		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr21:11064287_11064288insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTTCCACAGCAATCTTTCTAA	0.416													10	6	---	---	---	---						A	11064288	-	A	11064287	6	5	6	0	1	1	1	0	0	0	0	0	1290	725	25	0		0	BAGE2	21	11064287	RNA	INS	-	TCGA-N5-A4RM-01A-11D-A28R-08	23840	11064287	37065608	64	404										
BAGE2	85319	broad.mit.edu	37	chr21	11076406	11076407	+	RNA	DEL	TT	TT	-													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	aattttgttttaatttactaTtttttttttctgacctttag					rs142727884		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr21:11076406_11076407delTT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		taatttactattttttttttct	0.287													4	3	---	---	---	---						-	11076407	TT	-	11076406	6	5	6	0	1	1	0	1	0	0	0	0	1290	1508	52	0		0	BAGE2	21	11076406	RNA	DEL	TT	TCGA-N5-A4RM-01A-11D-A28R-08	12119	11076406	37053489	65	405										
KRTAP19-6	337973	broad.mit.edu	37	chr21	31914007	31914007	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	cagagaatccatatccttcaCggcatgatgggcggcagcag	12	11	1	2	rs146590456		TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr21:31914007C>T	ENST00000334046.5	-	1	176	c.146G>A	c.(145-147)cGt>cAt	p.R49H		NM_181612.2	NP_853643.1	Q3LI70	KR196_HUMAN	keratin associated protein 19-6	49						intermediate filament		p.R49H(1)		breast(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	9						ATATCCTTCACGGCATGATGG	0.493													133	161					0	0	1	0	0	T	31914007	C	T	31914007	3	4	6	1	0	0	0	0	1	0	0	0	8575	536	19	1	34	1	KRTAP19-6	21	31914007	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08	20837601	31914007	16215888	66	406										
PI4KA	5297	broad.mit.edu	37	chr22	21084273	21084273	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	ccgagagccgacagttatgtCcaggttgctccgggtgtcct	13	12	0	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chr22:21084273C>A	ENST00000255882.6	-	37	4401	c.4315G>T	c.(4315-4317)Gac>Tac	p.D1439Y	PI4KA_ENST00000572273.1_Missense_Mutation_p.D1381Y|PI4KA_ENST00000414196.3_Missense_Mutation_p.D191Y	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1381					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			ACAGTTATGTCCAGGTTGCTC	0.493													28	33					1.42536e-11	1.59813e-11	1	1	0	A	21084273	C	A	21084273	3	1	6	1	0	0	0	0	1	0	0	0	11920	855	30	2	2069	2	PI4KA	22	21084273	Missense_Mutation	SNP	C	TCGA-N5-A4RM-01A-11D-A28R-08		21084273	30220293	67	407										
SMC1A	8243	broad.mit.edu	37	chrX	53432009	53432009	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	actctgggagtacttgagccGcatctgcagtccatgggcct	12	12	2	1			TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chrX:53432009G>A	ENST00000322213.4	-	13	2258	c.2131C>T	c.(2131-2133)Cgg>Tgg	p.R711W	SMC1A_ENST00000375340.6_Missense_Mutation_p.R477W	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	711			R -> Q (in CDLS2).|R -> W (in CDLS2).		cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity	p.R711W(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						TACTTGAGCCGCATCTGCAGT	0.562													21	4					0	0	1	0	0	A	53432009	G	A	53432009	3	1	6	1	0	0	0	0	1	0	0	0	14834	1086	38	1	1622	1	SMC1A	23	53432009	Missense_Mutation	SNP	G	TCGA-N5-A4RM-01A-11D-A28R-08		53432009	101838551	68	408										
FAM120C	54954	broad.mit.edu	37	chrX	54209302	54209303	+	In_Frame_Ins	INS	-	-	GGCGGC													0.0579710144927536	4	1	0.823990355635925	2.88396624472574	0.262178749520522	0.523809523809524	1	0	gggccccgggcagctgagggINSggcggcggcggcggcagcgg							TCGA-N5-A4RM-01A-11D-A28R-08	TCGA-N5-A4RM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	643ce1e5-5d7b-42a7-be84-fff6e1f00788	fbe85c1e-c6b0-4a9a-91cc-189ca341431f	g.chrX:54209302_54209303insGGCGGC	ENST00000375180.2	-	1	385_386	c.329_330insGCCGCC	c.(328-330)ccc>cGCCGCCcc	p.109_110insRR	FAM120C_ENST00000477084.1_In_Frame_Ins_p.109_110insRR|FAM120C_ENST00000328235.4_In_Frame_Ins_p.109_110insRR	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	109										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCAGCTGAGGGGGCGGCGGCGG	0.748													5	5	---	---	---	---						GGCGGC	54209303	-	GGCGGC	54209302	7	5	6	1	0	1	1	0	0	0	0	0	5449	1219	43	0	3046	0	FAM120C	23	54209302	In_Frame_Ins	INS	-	TCGA-N5-A4RM-01A-11D-A28R-08	777293	54209302	101061258	69	409										
RAD54L	8438	broad.mit.edu	37	chr1	46714224	46714224	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ccagctggccaagagaaaacCtgaaggcaggtcctgtgatg	13	10	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:46714224C>A	ENST00000371975.4	+	2	718	c.44C>A	c.(43-45)cCt>cAt	p.P15H	RAD54L_ENST00000442598.1_Missense_Mutation_p.P15H	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	15					meiosis	nucleus	ATP binding|DNA binding|helicase activity	p.P15H(1)		breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		AAGAGAAAACCTGAAGGCAGG	0.547								Direct reversal of damage;Homologous recombination					18	35					5.35267e-07	5.84828e-07	1	1	0	A	46714224	C	A	46714224	3	1	7	1	0	0	0	0	1	0	0	0	13044	681	24	5	50	5	RAD54L	1	46714224	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		46714224	202536397	1	410										
CDCP2	200008	broad.mit.edu	37	chr1	54605311	54605311	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ggagaaggagctggagaagaCcattcatggggggggcagga	20	5	1	3	rs138436244	byFrequency	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:54605311C>T	ENST00000371330.1	-	4	2079	c.1232G>A	c.(1231-1233)gGt>gAt	p.G411D	CDCP2_ENST00000530059.1_Intron	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	411						extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						CTGGAGAAGACCATTCATGGG	0.597													50	23					0	0	1	0	0	T	54605311	C	T	54605311	3	4	7	1	0	0	0	0	1	0	0	0	3116	507	18	3	121	3	CDCP2	1	54605311	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	7891087	54605311	194645310	2	411										
INADL	10207	broad.mit.edu	37	chr1	62582864	62582864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gagctggttcctggacctccGcaaggacgacatcacagaac	11	13	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:62582864G>A	ENST00000371158.2	+	37	4978	c.4864G>A	c.(4864-4866)Gca>Aca	p.A1622T	INADL_ENST00000543708.1_Missense_Mutation_p.A436T	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1622					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CTGGACCTCCGCAAGGACGAC	0.483													3	30					0	0	1	0	0	A	62582864	G	A	62582864	3	1	7	1	0	0	0	0	1	0	0	0	7774	1087	38	1	5006	1	INADL	1	62582864	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	7977553	62582864	186667757	3	412										
RPRD2	23248	broad.mit.edu	37	chr1	150444176	150444176	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ggctatttggtgccttcagcGtaagagggaatgaacctggg	15	7	1	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:150444176G>A	ENST00000401000.4	+	10	2739	c.2674G>A	c.(2674-2676)Gta>Ata	p.V892I	RPRD2_ENST00000539519.1_Missense_Mutation_p.V892I|RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.V918I			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	918	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TGCCTTCAGCGTAAGAGGGAA	0.507													5	367					0	0	1	0	0	A	150444176	G	A	150444176	3	1	7	1	0	0	0	0	1	0	0	0	13668	1145	40	1	2794	1	RPRD2	1	150444176	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	87861312	150444176	98806445	4	413										
LINGO4	339398	broad.mit.edu	37	chr1	151774911	151774911	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gagagctggttgtagctgagGtccaattcctggagcaggct	15	8	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:151774911G>T	ENST00000368820.3	-	2	1207	c.270C>A	c.(268-270)gaC>gaA	p.D90E		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	90						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGTAGCTGAGGTCCAATTCCT	0.612													10	68					0.00621372	0.00637581	1	1	0	T	151774911	G	T	151774911	3	4	7	1	0	0	0	0	1	0	0	0	8857	1252	44	5	1515	5	LINGO4	1	151774911	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	1330735	151774911	97475710	5	414										
MAEL	84944	broad.mit.edu	37	chr1	166962019	166962019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cctcccttgtgaaattggctGtgttaagtattctctccaag	8	10	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:166962019G>A	ENST00000367872.4	+	4	666	c.422G>A	c.(421-423)tGt>tAt	p.C141Y	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.C110Y	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	141					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						GAAATTGGCTGTGTTAAGTAT	0.398													21	87					0	0	1	0	0	A	166962019	G	A	166962019	3	1	7	1	0	0	0	0	1	0	0	0	9199	1377	48	3	436	3	MAEL	1	166962019	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	15187108	166962019	82288602	6	415										
RCSD1	92241	broad.mit.edu	37	chr1	167663457	167663457	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ccccagcagccctggtgtgcGatctaggcccagcgaggcag	14	15	1	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:167663457G>A	ENST00000367854.3	+	5	723	c.392G>A	c.(391-393)cGa>cAa	p.R131Q	RCSD1_ENST00000537350.1_Missense_Mutation_p.R101Q	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	131										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CCTGGTGTGCGATCTAGGCCC	0.592													9	84					0	0	1	0	0	A	167663457	G	A	167663457	3	1	7	1	0	0	0	0	1	0	0	0	13236	1058	37	1	410	1	RCSD1	1	167663457	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	701438	167663457	81587164	7	416										
KIF14	9928	broad.mit.edu	37	chr1	200584490	200584491	+	Frame_Shift_Ins	INS	-	-	T													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aatacaacttacgtatatgaINSttttccagagccagtctgac							TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:200584490_200584491insT	ENST00000367350.4	-	3	1797_1798	c.1359_1360insA	c.(1357-1362)aacatafs	p.NI453fs		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	453	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TACGTATATGATTTTCCAGAGC	0.381													38	50	---	---	---	---						T	200584491	-	T	200584490	7	5	7	1	0	1	1	0	0	0	0	0	8317	333	12	0	3698	0	KIF14	1	200584490	Frame_Shift_Ins	INS	-	TCGA-N5-A4RN-01A-12D-A28R-08	32921033	200584490	48666131	8	417										
KIF26B	55083	broad.mit.edu	37	chr1	245775144	245775144	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	caccgcagagaaggctgcctTtttcctggatgccgccattg	11	13	0	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:245775144T>G	ENST00000366518.4	+	6	925	c.821T>G	c.(820-822)tTt>tGt	p.F274C	KIF26B_ENST00000407071.2_Missense_Mutation_p.F655C			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	655					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGGCTGCCTTTTTCCTGGAT	0.602													19	52					0	0	1	0	0	G	245775144	T	G	245775144	3	3	7	1	0	0	0	0	1	0	0	0	8336	1841	64	4	1998	4	KIF26B	1	245775144	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	45190654	245775144	3475477	9	418										
PXDN	7837	broad.mit.edu	37	chr2	1652752	1652752	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gatgccctgccgcagcaggcCgcggtggctggccaggtcgc	17	15	0	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:1652752C>T	ENST00000252804.4	-	17	2850	c.2800G>A	c.(2800-2802)Ggc>Agc	p.G934S		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	934					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGCAGCAGGCCGCGGTGGCTG	0.692													18	28					0	0	1	0	0	T	1652752	C	T	1652752	3	4	7	1	0	0	0	0	1	0	0	0	12898	652	23	1	1667	1	PXDN	2	1652752	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		1652752	241546621	10	419										
MTIF2	4528	broad.mit.edu	37	chr2	55463904	55463904	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ctgagaccacaatccattccCgttttgacaattgaaatgtc	6	11	0	3	rs138084091	byFrequency	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:55463904C>A	ENST00000394600.3	-	17	2800	c.2064G>T	c.(2062-2064)acG>acT	p.T688T	MTIF2_ENST00000263629.4_Silent_p.T688T|MTIF2_ENST00000403721.1_Silent_p.T688T	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	688					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						AATCCATTCCCGTTTTGACAA	0.313													5	17					0.184627	0.184627	1	1	0	A	55463904	C	A	55463904	2	1	7	1	0	0	0	0	0	0	0	1	9981	639	23	5		5	MTIF2	2	55463904	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	53811152	55463904	187735469	11	420										
BCL11A	53335	broad.mit.edu	37	chr2	60773229	60773229	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttttttcatctcgattggtgAaggggaaggtggcttatcca	12	6	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:60773229A>G	ENST00000335712.6	-	2	489	c.262T>C	c.(262-264)Tca>Cca	p.S88P	BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000358510.4_Missense_Mutation_p.S88P|BCL11A_ENST00000356842.4_Missense_Mutation_p.S88P|BCL11A_ENST00000538214.1_Missense_Mutation_p.S88P|BCL11A_ENST00000359629.5_Missense_Mutation_p.S88P	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	88	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TCGATTGGTGAAGGGGAAGGT	0.463			T	IGH@	B-CLL								20	46					0	0	1	0	0	G	60773229	A	G	60773229	3	3	7	1	0	0	0	0	1	0	0	0	1361	246	9	4	2363	4	BCL11A	2	60773229	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08	5309325	60773229	182426144	12	421										
HAT1	8520	broad.mit.edu	37	chr2	172822005	172822007	+	In_Frame_Del	DEL	AGG	AGG	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tactcagttctcagtccaacAggaggagaaaactttacctt							TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:172822005_172822007delAGG	ENST00000264108.4	+	5	492_494	c.456_458delAGG	c.(454-459)aca>ac	p.TG152del	HAT1_ENST00000392584.1_In_Frame_Del_p.TG67del|SLC25A12_ENST00000472748.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	152					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TCAGTCCAACAGGAGGAGAAAAC	0.335													8	22	---	---	---	---						-	172822007	AGG	-	172822005	7	5	7	1	0	1	0	1	0	0	0	0	7004	175	7	0	474	0	HAT1	2	172822005	In_Frame_Del	DEL	AGG	TCGA-N5-A4RN-01A-12D-A28R-08	112048776	172822005	70377368	13	422										
PLCL1	5334	broad.mit.edu	37	chr2	198949947	198949947	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgaaatgtctcgaaggatgtCggtagattacaatggtgagc	13	5	1	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:198949947C>T	ENST00000428675.1	+	2	2104	c.1706C>T	c.(1705-1707)tCg>tTg	p.S569L	PLCL1_ENST00000437704.2_Missense_Mutation_p.S471L	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	569					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CGAAGGATGTCGGTAGATTAC	0.398													21	45					0	0	1	0	0	T	198949947	C	T	198949947	3	4	7	1	0	0	0	0	1	0	0	0	12086	893	31	1	1712	1	PLCL1	2	198949947	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	26127942	198949947	44249426	14	423										
ROBO1	6091	broad.mit.edu	37	chr3	78683127	78683127	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgagctgttgtaggatcctcCtgtgttctggtcgtatgatt	12	7	1	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:78683127C>T	ENST00000436010.2	-	22	4319	c.3322G>A	c.(3322-3324)Gga>Aga	p.G1108R	ROBO1_ENST00000464233.1_Missense_Mutation_p.G1147R|ROBO1_ENST00000495273.1_Missense_Mutation_p.G1102R|ROBO1_ENST00000467549.1_Missense_Mutation_p.G1047R			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1147					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TAGGATCCTCCTGTGTTCTGG	0.393													14	32					0	0	1	0	0	T	78683127	C	T	78683127	3	4	7	1	0	0	0	0	1	0	0	0	13564	690	24	3	1548	3	ROBO1	3	78683127	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		78683127	119339303	15	424										
CPOX	1371	broad.mit.edu	37	chr3	98304286	98304286	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tcgttttccagtcacttaccGtcctcttctgagctgctgcc	7	15	3	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:98304286G>C	ENST00000264193.2	-	5	1389	c.1172_splice	c.e5+1	p.R391_splice		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	391						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						GTCACTTACCGTCCTCTTCTG	0.478													47	144					0	0	1	0	0	C	98304286	G	C	98304286	5	2	7	1	0	0	0	0	0	0	1	0	3844	1159	40	5	205	5	CPOX	3	98304286	Splice_Site	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	19621159	98304286	99718144	16	425										
ZBTB11	27107	broad.mit.edu	37	chr3	101395550	101395550	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cctcgatgaggtcccggcgtCgctccggctgcagcaccacc	12	18	0	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:101395550C>T	ENST00000312938.4	-	1	789	c.209G>A	c.(208-210)cGa>cAa	p.R70Q	ZBTB11_ENST00000461821.1_Missense_Mutation_p.R70Q|ZBTB11-AS1_ENST00000536865.1_Missense_Mutation_p.S21L	NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	70					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						GTCCCGGCGTCGCTCCGGCTG	0.692													13	1					0	0	1	0	0	T	101395550	C	T	101395550	3	4	7	1	0	0	0	0	1	0	0	0	17582	884	31	1	2996	1	ZBTB11	3	101395550	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	3091264	101395550	96626880	17	426										
STAG1	10274	broad.mit.edu	37	chr3	136342011	136342011	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aggccggccaggacgaccccTttttctttttcctttgacct	8	14	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:136342011T>C	ENST00000383202.2	-	3	365	c.109A>G	c.(109-111)Agg>Ggg	p.R37G	STAG1_ENST00000236698.5_Missense_Mutation_p.R37G|STAG1_ENST00000434713.2_5'UTR|STAG1_ENST00000480733.1_Missense_Mutation_p.R37G	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	37					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GGACGACCCCTTTTTCTTTTT	0.388													4	207					0	0	1	0	0	C	136342011	T	C	136342011	3	2	7	1	0	0	0	0	1	0	0	0	15297	1608	56	4	3795	4	STAG1	3	136342011	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	34946461	136342011	61680419	18	427										
CCDC39	339829	broad.mit.edu	37	chr3	180337633	180337633	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tttttaaaagattgcttataAttgttgttacagctgttcag	7	4	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:180337633A>T	ENST00000442201.2	-	15	2243	c.2124T>A	c.(2122-2124)aaT>aaA	p.N708K	CCDC39_ENST00000273654.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	708					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATTGCTTATAATTGTTGTTAC	0.338													4	16					0	0	1	0	0	T	180337633	A	T	180337633	3	4	7	1	0	0	0	0	1	0	0	0	2830	98	4	4	725	4	CCDC39	3	180337633	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08	43995622	180337633	17684797	19	428										
MUC4	4585	broad.mit.edu	37	chr3	195508194	195508194	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ggaagaggggtggcgtgaccTgtggatgctgaggaagggct	21	5	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:195508194T>G	ENST00000463781.3	-	2	10716	c.10257A>C	c.(10255-10257)acA>acC	p.T3419T	MUC4_ENST00000475231.1_Silent_p.T3419T|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	187					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGGCGTGACCTGTGGATGCTG	0.587													4	11					0	0	1	0	0	G	195508194	T	G	195508194	2	3	7	1	0	0	0	0	0	0	0	1	10025	1567	55	4		4	MUC4	3	195508194	Silent	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	15170561	195508194	2514236	20	429										
ADAMTS3	9508	broad.mit.edu	37	chr4	73188778	73188778	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	caccaggaccacatttatatGcactccgagggactcatcat	7	13	2	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:73188778G>A	ENST00000286657.4	-	6	934	c.898C>T	c.(898-900)Cat>Tat	p.H300Y	RP11-373J21.1_ENST00000503918.1_RNA	NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	300	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACATTTATATGCACTCCGAGG	0.363													36	122					0	0	1	0	0	A	73188778	G	A	73188778	3	1	7	1	0	0	0	0	1	0	0	0	266	1319	46	3	2787	3	ADAMTS3	4	73188778	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08		73188778	117965498	21	430										
TET2	54790	broad.mit.edu	37	chr4	106157271	106157271	+	Frame_Shift_Del	DEL	T	T	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cttttgcaacataagcctcaTaaacaggcagcacaaacaca							TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:106157271delT	ENST00000513237.1	+	3	3032	c.2235delT	c.(2233-2235)cafs	p.H745fs	TET2_ENST00000380013.4_Frame_Shift_Del_p.H724fs|TET2_ENST00000305737.2_Frame_Shift_Del_p.H724fs|TET2_ENST00000413648.2_Frame_Shift_Del_p.H724fs|TET2_ENST00000545826.1_Frame_Shift_Del_p.H724fs|TET2_ENST00000394764.1_Frame_Shift_Del_p.H724fs|TET2_ENST00000540549.1_Frame_Shift_Del_p.H724fs			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	724	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.H724fs*29(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ATAAGCCTCATAAACAGGCAG	0.408			"Mis N, F"		MDS								20	22	---	---	---	---						-	106157271	T	-	106157271	7	5	7	1	0	1	0	1	0	0	0	0	15828	1403	49	0	2174	0	TET2	4	106157271	Frame_Shift_Del	DEL	T	TCGA-N5-A4RN-01A-12D-A28R-08	32968493	106157271	84997005	22	431										
MFSD8	256471	broad.mit.edu	37	chr4	128878655	128878655	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttatgtatttctaatacttaCctacactgctgagaaacata	4	8	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:128878655C>A	ENST00000296468.3	-	3	282		c.e3+1		MFSD8_ENST00000513559.1_Splice_Site|MFSD8_ENST00000541133.1_Splice_Site|MFSD8_ENST00000515130.1_Splice_Site	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8						cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						CTAATACTTACCTACACTGCT	0.299													13	33					5.50884e-06	5.9637e-06	1	1	0	A	128878655	C	A	128878655	5	1	7	1	0	0	0	0	0	0	1	0	9587	521	18	5	1445	5	MFSD8	4	128878655	Splice_Site	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	22721384	128878655	62275621	23	432										
SMARCA5	8467	broad.mit.edu	37	chr4	144445586	144445586	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	acagaaagctccaaagcaacCaatgtttgcactcgatttga	7	10	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:144445586C>T	ENST00000283131.3	+	4	948	c.486C>T	c.(484-486)acC>acT	p.T162T		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	162					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding		EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					CCAAAGCAACCAATGTTTGCA	0.363													12	25					0	0	1	0	0	T	144445586	C	T	144445586	2	4	7	1	0	0	0	0	0	0	0	1	14824	581	21	3		3	SMARCA5	4	144445586	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	15566931	144445586	46708690	24	433										
FBXW7	0	broad.mit.edu	37	chr4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aaaccctaagagtggcatctCgagaaccgctaacaactctg	8	12	2	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:153247366C>T	ENST00000281708.4	-	10	2665	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	FBXW7_ENST00000603548.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000393956.3_Missense_Mutation_p.R303Q|FBXW7_ENST00000263981.5_Missense_Mutation_p.R399Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000296555.5_Missense_Mutation_p.R361Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	479					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R479Q(29)|p.R479L(5)|p.R399Q(3)|p.R479P(2)|p.R240L(1)|p.R361P(1)|p.R399P(1)|p.?(1)|p.R361Q(1)|p.R399L(1)|p.R240Q(1)|p.R240P(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								53	46					0	0	1	0	0	T	153247366	C	T	153247366	3	4	7	1	0	0	0	0	1	0	0	0	5801	884	31	1	699	1	FBXW7	4	153247366	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	8801780	153247366	37906910	25	434										
MRPL36	64979	broad.mit.edu	37	chr5	1798835	1798835	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	agtccttgcagcgcttcttaAggacagtcttgtttttgaac	9	9	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:1798835A>G	ENST00000508987.1	-	2	351	c.215T>C	c.(214-216)cTt>cCt	p.L72P	MRPL36_ENST00000382647.7_Missense_Mutation_p.L72P|MRPL36_ENST00000505818.1_Missense_Mutation_p.L72P|MRPL36_ENST00000505059.2_Missense_Mutation_p.L72P			Q9P0J6	RM36_HUMAN	mitochondrial ribosomal protein L36	72					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(2)	3				GBM - Glioblastoma multiforme(108;0.241)		GCGCTTCTTAAGGACAGTCTT	0.592													8	365					0	0	1	0	0	G	1798835	A	G	1798835	3	3	7	1	0	0	0	0	1	0	0	0	9847	72	3	4	100	4	MRPL36	5	1798835	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08		1798835	179116425	26	435										
IRX2	153572	broad.mit.edu	37	chr5	2749656	2749656	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aggcgccggcgcgcgttggcGaaccaggtggagacctgggt	19	11	0	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:2749656G>C	ENST00000382611.6	-	2	743	c.495C>G	c.(493-495)ttC>ttG	p.F165L	IRX2_ENST00000302057.5_Missense_Mutation_p.F165L|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	165						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		GCGCGTTGGCGAACCAGGTGG	0.597													47	873					0	0	1	0	0	C	2749656	G	C	2749656	3	2	7	1	0	0	0	0	1	0	0	0	7887	1049	37	2	932	2	IRX2	5	2749656	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	950821	2749656	178165604	27	436										
UGT3A1	133688	broad.mit.edu	37	chr5	35954581	35954581	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ccaccactgccgacttgtacCtgttggcggagacagagagg	13	12	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:35954581C>T	ENST00000274278.3	-	7	1653		c.e7-1			NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1							integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGACTTGTACCTGTTGGCGGA	0.547													6	26					0	0	1	0	0	T	35954581	C	T	35954581	5	4	7	1	0	0	0	0	0	0	1	0	17022	695	24	3	280	3	UGT3A1	5	35954581	Splice_Site	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	33204925	35954581	144960679	28	437										
HIST1H2BJ	8970	broad.mit.edu	37	chr6	27100485	27100485	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gccttagtcaccgccttcttGgagccctttttcggggcggg	13	13	2	0	rs115912638	by1000genomes	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:27100485G>A	ENST00000607124.1	-	1	44	c.45C>T	c.(43-45)tcC>tcT	p.S15S	HIST1H2BJ_ENST00000339812.2_Silent_p.S15S|HIST1H2BJ_ENST00000541790.1_Silent_p.S15S			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						CCGCCTTCTTGGAGCCCTTTT	0.537													41	160					0	0	1	0	0	A	27100485	G	A	27100485	2	1	7	1	0	0	0	0	0	0	0	1	7189	1335	47	3		3	HIST1H2BJ	6	27100485	Silent	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08		27100485	144014582	29	438										
NOTCH4	4855	broad.mit.edu	37	chr6	32169084	32169084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cagagtcagggacagcacccGggccagggcaaacagctgct	14	13	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:32169084G>A	ENST00000375023.3	-	22	4087	c.3949C>T	c.(3949-3951)Cgg>Tgg	p.R1317W		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1317					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GACAGCACCCGGGCCAGGGCA	0.642													17	85					0	0	1	0	0	A	32169084	G	A	32169084	3	1	7	1	0	0	0	0	1	0	0	0	10597	1115	39	1	2098	1	NOTCH4	6	32169084	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	5068599	32169084	138945983	30	439										
SYNGAP1	8831	broad.mit.edu	37	chr6	33391325	33391325	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	atcgtcctggttggaaccctCggttctgcatcatctcgggg	12	12	3	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:33391325C>T	ENST00000418600.2	+	2	240	c.139C>T	c.(139-141)Cgg>Tgg	p.R47W	SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.R47W	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	47					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TTGGAACCCTCGGTTCTGCAT	0.542													43	172					0	0	1	0	0	T	33391325	C	T	33391325	3	4	7	1	0	0	0	0	1	0	0	0	15503	875	31	1	145	1	SYNGAP1	6	33391325	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	1222241	33391325	137723742	31	440										
KCNK5	8645	broad.mit.edu	37	chr6	39162482	39162482	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gcggcaccccgaagagaccaTagaaaacacagaagaggcga	12	11	0	4			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:39162482T>C	ENST00000359534.3	-	3	691	c.353A>G	c.(352-354)tAt>tGt	p.Y118C		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	118					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						GAAGAGACCATAGAAAACACA	0.582													39	177					0	0	1	0	0	C	39162482	T	C	39162482	3	2	7	1	0	0	0	0	1	0	0	0	8112	1406	49	4	1158	4	KCNK5	6	39162482	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	5771157	39162482	131952585	32	441										
MCM3	4172	broad.mit.edu	37	chr6	52143605	52143605	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	agcagagaaagagggctgagCatccttgctcatctgcttaa	11	9	2	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:52143605C>A	ENST00000596288.1	-	6	976	c.949G>T	c.(949-951)Gct>Tct	p.A317S	MCM3_ENST00000419835.2_Missense_Mutation_p.A226S|MCM3_ENST00000476448.1_5'UTR|MCM3_ENST00000229854.7_Missense_Mutation_p.A272S	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	272	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GAGGGCTGAGCATCCTTGCTC	0.438													10	109					0.0581538	0.0591564	1	1	0	A	52143605	C	A	52143605	3	1	7	1	0	0	0	0	1	0	0	0	9436	710	25	5	1660	5	MCM3	6	52143605	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	12981123	52143605	118971462	33	442										
IMPG1	3617	broad.mit.edu	37	chr6	76715225	76715225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgtgtctcttaaagatggccGtaagttgcatctctgtggag	12	7	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:76715225G>A	ENST00000369950.3	-	10	1103	c.914C>T	c.(913-915)aCg>aTg	p.T305M	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	305	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AAAGATGGCCGTAAGTTGCAT	0.448													17	94					0	0	1	0	0	A	76715225	G	A	76715225	3	1	7	1	0	0	0	0	1	0	0	0	7771	1145	40	1	1511	1	IMPG1	6	76715225	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	24571620	76715225	94399842	34	443										
DOPEY1	23033	broad.mit.edu	37	chr6	83846928	83846928	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	catcacatcaaaaggaaatgGtgaaaagccacttaccatgg	8	9	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:83846928G>T	ENST00000349129.2	+	21	3427	c.3167G>T	c.(3166-3168)gGt>gTt	p.G1056V	DOPEY1_ENST00000237163.5_Missense_Mutation_p.G1037V|DOPEY1_ENST00000369739.3_Missense_Mutation_p.G1047V	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1056					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAAGGAAATGGTGAAAAGCCA	0.338													9	47					0.00621372	0.00637581	1	1	0	T	83846928	G	T	83846928	3	4	7	1	0	0	0	0	1	0	0	0	4734	1261	44	5	3241	5	DOPEY1	6	83846928	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	7131703	83846928	87268139	35	444										
SYNE1	23345	broad.mit.edu	37	chr6	152823805	152823805	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cagtgcttgcattgtggatgTcaggataatgtttcagaaac	11	6	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:152823805T>A	ENST00000367255.5	-	10	1452	c.851A>T	c.(850-852)gAc>gTc	p.D284V	SYNE1_ENST00000367248.3_Missense_Mutation_p.D291V|SYNE1_ENST00000466159.2_Missense_Mutation_p.D284V|SYNE1_ENST00000423061.1_Missense_Mutation_p.D291V|SYNE1_ENST00000265368.4_Missense_Mutation_p.D284V|SYNE1_ENST00000448038.1_Missense_Mutation_p.D291V|SYNE1_ENST00000341594.5_Missense_Mutation_p.D284V|SYNE1_ENST00000367253.4_Missense_Mutation_p.D284V|SYNE1_ENST00000413186.2_Missense_Mutation_p.D284V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	284	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTGTGGATGTCAGGATAATG	0.373										HNSCC(10;0.0054)			9	44					0	0	1	0	0	A	152823805	T	A	152823805	3	1	7	1	0	0	0	0	1	0	0	0	15501	1667	58	4	26163	4	SYNE1	6	152823805	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	68976877	152823805	18291262	36	445										
ZNF680	340252	broad.mit.edu	37	chr7	63981662	63981662	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttgccacattcttcacatttGtagggtttctctctagcatg	7	10	4	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr7:63981662G>A	ENST00000309683.6	-	4	1621	c.1470C>T	c.(1468-1470)taC>taT	p.Y490Y		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				CTTCACATTTGTAGGGTTTCT	0.383													6	102					0	0	1	0	0	A	63981662	G	A	63981662	2	1	7	1	0	0	0	0	0	0	0	1	18142	1372	48	3		3	ZNF680	7	63981662	Silent	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08		63981662	95157001	37	446										
TOX	9760	broad.mit.edu	37	chr8	59728107	59728107	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttcggcttgggggctatgttCctggggagactaggatgcat	16	7	0	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr8:59728107C>A	ENST00000361421.1	-	7	1402	c.1182G>T	c.(1180-1182)agG>agT	p.R394S		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	394						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GGGCTATGTTCCTGGGGAGAC	0.567													25	50					1.55469e-16	1.76398e-16	1	1	0	A	59728107	C	A	59728107	3	1	7	1	0	0	0	0	1	0	0	0	16437	854	30	2	410	2	TOX	8	59728107	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		59728107	86635915	38	447										
LRRCC1	85444	broad.mit.edu	37	chr8	86038971	86038971	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	agagagaagagatggagagcTgagcaagccgaaaataaact	13	5	0	5			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr8:86038971T>G	ENST00000414626.2	+	8	2149	c.1260T>G	c.(1258-1260)gcT>gcG	p.A420A	LRRCC1_ENST00000360375.3_Silent_p.A440A			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	440					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						GATGGAGAGCTGAGCAAGCCG	0.373													13	24					0	0	1	0	0	G	86038971	T	G	86038971	2	3	7	1	0	0	0	0	0	0	0	1	9070	1567	55	4		4	LRRCC1	8	86038971	Silent	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	26310864	86038971	60325051	39	448										
RAD54B	25788	broad.mit.edu	37	chr8	95403998	95403998	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aatctgtagtgctcctggtcGgcaaaagacaacattctcta	8	10	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr8:95403998G>A	ENST00000336148.5	-	10	1772	c.1648C>T	c.(1648-1650)Cga>Tga	p.R550*		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GCTCCTGGTCGGCAAAAGACA	0.393								Direct reversal of damage;Homologous recombination					40	96					0	0	1	0	0	A	95403998	G	A	95403998	4	1	7	1	0	0	0	0	0	1	0	0	13043	1124	39	1	1108	1	RAD54B	8	95403998	Nonsense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	9365027	95403998	50960024	40	449										
OR1N2	138882	broad.mit.edu	37	chr9	125315642	125315642	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gaacctgctcattatcctggCcatcagctctgacccacacc	6	17	3	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr9:125315642C>A	ENST00000373688.2	+	1	252	c.194C>A	c.(193-195)gCc>gAc	p.A65D		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						ATTATCCTGGCCATCAGCTCT	0.522													45	44					2.43468e-25	2.81659e-25	1	1	0	A	125315642	C	A	125315642	3	1	7	1	0	0	0	0	1	0	0	0	11017	739	26	5	196	5	OR1N2	9	125315642	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		125315642	15897789	41	450										
ZNF33B	7582	broad.mit.edu	37	chr10	43088129	43088129	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	atttgacttttgagagaaggTtttcctgcatgtgttacatt	9	5	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:43088129T>G	ENST00000359467.3	-	5	2383	c.2269A>C	c.(2269-2271)Acc>Ccc	p.T757P	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	757						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						TGAGAGAAGGTTTTCCTGCAT	0.358													27	116					0	0	1	0	0	G	43088129	T	G	43088129	3	3	7	1	0	0	0	0	1	0	0	0	17911	1725	60	4	71	4	ZNF33B	10	43088129	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08		43088129	92446618	42	451										
MYPN	84665	broad.mit.edu	37	chr10	69918245	69918245	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttcttcttatcattatagatGctacaaaatttgtcagcttc	4	8	4	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:69918245G>T	ENST00000358913.5	+	7	1808	c.1320G>T	c.(1318-1320)atG>atT	p.M440I	MYPN_ENST00000373675.3_Missense_Mutation_p.M440I|MYPN_ENST00000540630.1_Missense_Mutation_p.M440I|MYPN_ENST00000354393.2_Missense_Mutation_p.M165I	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	440	Ig-like 2.|Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CATTATAGATGCTACAAAATT	0.363													4	37					0.000602214	0.000634476	1	1	0	T	69918245	G	T	69918245	3	4	7	1	0	0	0	0	1	0	0	0	10145	1319	46	5	1342	5	MYPN	10	69918245	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	26830116	69918245	65616502	43	452										
C10orf2	56652	broad.mit.edu	37	chr10	102748377	102748377	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ggggcgaggggatggggccaGggaggggtttctgcttagca	22	6	1	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:102748377G>T	ENST00000370228.1	+	1	595	c.410G>T	c.(409-411)aGg>aTg	p.R137M	C10orf2_ENST00000311916.2_Missense_Mutation_p.R137M|C10orf2_ENST00000473656.1_Intron	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	137					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GATGGGGCCAGGGAGGGGTTT	0.592													15	255					0.000422831	0.000449496	1	1	0	T	102748377	G	T	102748377	3	4	7	1	0	0	0	0	1	0	0	0	1601	1000	35	5	412	5	C10orf2	10	102748377	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	32830132	102748377	32786370	44	453										
SORCS3	22986	broad.mit.edu	37	chr10	107007067	107007067	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gagaaaagatattggcaatgTcatcaagcgagctctggtta	11	6	3	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:107007067T>A	ENST00000369701.3	+	22	3310	c.3083T>A	c.(3082-3084)gTc>gAc	p.V1028D	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1028						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATTGGCAATGTCATCAAGCGA	0.393													9	34					0	0	1	0	0	A	107007067	T	A	107007067	3	1	7	1	0	0	0	0	1	0	0	0	14985	1667	58	4	3169	4	SORCS3	10	107007067	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	4258690	107007067	28527680	45	454										
SEC23IP	11196	broad.mit.edu	37	chr10	121668600	121668601	+	Frame_Shift_Del	DEL	AG	AG	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aatcagtggcaccgaagattAgagtttccaagtggagagac							TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:121668600_121668601delAG	ENST00000369075.3	+	5	1221_1222	c.1149_1150delAG	c.(1147-1152)ttagfs	p.LE383fs	SEC23IP_ENST00000543134.1_Frame_Shift_Del_p.LE172fs	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	383					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		ACCGAAGATTAGAGTTTCCAAG	0.327													11	49	---	---	---	---						-	121668601	AG	-	121668600	7	5	7	1	0	1	0	1	0	0	0	0	14046	417	15	0	1167	0	SEC23IP	10	121668600	Frame_Shift_Del	DEL	AG	TCGA-N5-A4RN-01A-12D-A28R-08	14661533	121668600	13866147	46	455										
OR51Q1	390061	broad.mit.edu	37	chr11	5443752	5443752	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ctcagtttttcttccttcatGgattctcctttatggagtct	6	10	5	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:5443752G>T	ENST00000300778.4	+	1	412	c.322G>T	c.(322-324)Gga>Tga	p.G108*	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCCTTCATGGATTCTCCTT	0.502													57	38					2.14674e-31	2.50807e-31	1	1	0	T	5443752	G	T	5443752	4	4	7	1	0	0	0	0	0	1	0	0	11151	1349	47	5	324	5	OR51Q1	11	5443752	Nonsense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08		5443752	129562764	47	456										
NR1H3	10062	broad.mit.edu	37	chr11	47282969	47282969	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgcccagcaacagtgtaaccGgcgctccttttctgaccggc	10	15	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:47282969G>A	ENST00000467728.1	+	4	1915	c.677G>A	c.(676-678)cGg>cAg	p.R226Q	NR1H3_ENST00000481889.2_Missense_Mutation_p.R181Q|NR1H3_ENST00000405853.3_Missense_Mutation_p.R226Q|NR1H3_ENST00000527949.1_Missense_Mutation_p.R135Q|NR1H3_ENST00000405576.1_Missense_Mutation_p.R181Q|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000441012.2_Missense_Mutation_p.R226Q|NR1H3_ENST00000395397.3_Missense_Mutation_p.R181Q|NR1H3_ENST00000407404.1_Missense_Mutation_p.R226Q			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	226	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding	p.R226Q(1)		endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						CAGTGTAACCGGCGCTCCTTT	0.622													25	60					0	0	1	0	0	A	47282969	G	A	47282969	3	1	7	1	0	0	0	0	1	0	0	0	10665	1116	39	1	691	1	NR1H3	11	47282969	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	41839217	47282969	87723547	48	457										
OR9G1	390174	broad.mit.edu	37	chr11	56468604	56468604	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tcctcccacctgacctctgtCactttatactatggctccat	4	16	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:56468604C>A	ENST00000312153.1	+	1	741	c.741C>A	c.(739-741)gtC>gtA	p.V247V		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TGACCTCTGTCACTTTATACT	0.453													36	211					2.20474e-14	2.45433e-14	1	1	0	A	56468604	C	A	56468604	2	1	7	1	0	0	0	0	0	0	0	1	11296	813	29	2		2	OR9G1	11	56468604	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	9185635	56468604	78537912	49	458										
TMPRSS4	56649	broad.mit.edu	37	chr11	117969704	117969704	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tcccattttcttgcagatgtCaaacccctgcgcaaaccccg	6	16	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:117969704C>G	ENST00000534111.1	+	3	307	c.42C>G	c.(40-42)gtC>gtG	p.V14V	TMPRSS4_ENST00000522824.1_Silent_p.V16V|TMPRSS4_ENST00000522307.1_5'UTR|TMPRSS4_ENST00000437212.3_Silent_p.V16V|TMPRSS4_ENST00000523251.1_Intron	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022.1|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4	16					proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TTGCAGATGTCAAACCCCTGC	0.557													17	48					0	0	1	0	0	G	117969704	C	G	117969704	2	3	7	1	0	0	0	0	0	0	0	1	16308	813	29	2		2	TMPRSS4	11	117969704	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	61501100	117969704	17036812	50	459										
CD3E	916	broad.mit.edu	37	chr11	118178014	118178014	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	attttctagttggcgtttggGggcaagatggtgagatatgc	15	4	1	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:118178014G>A	ENST00000361763.4	+	3	352	c.61G>A	c.(61-63)Ggg>Agg	p.G21R	CD3E_ENST00000528600.1_Missense_Mutation_p.G21R	NM_000733.3	NP_000724.1	P07766	CD3E_HUMAN	CD3e molecule, epsilon (CD3-TCR complex)	21					G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|ovary(2)|stomach(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	TGGCGTTTGGGGGCAAGATGG	0.378													13	9					0	0	1	0	0	A	118178014	G	A	118178014	3	1	7	1	0	0	0	0	1	0	0	0	3033	1232	43	3	67	3	CD3E	11	118178014	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	208310	118178014	16828502	51	460										
DCTN2	10540	broad.mit.edu	37	chr12	57924490	57924490	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gctcactttcccagcttcttCatccgttcatcaatgctggc	6	15	5	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:57924490C>T	ENST00000548249.1	-	14	1455	c.1188G>A	c.(1186-1188)atG>atA	p.M396I	DCTN2_ENST00000543672.1_Missense_Mutation_p.M401I|DCTN2_ENST00000537439.1_Missense_Mutation_p.M373I|DCTN2_ENST00000434715.3_Missense_Mutation_p.M401I	NM_001261412.1|NM_001261413.1	NP_001248341.1|NP_001248342.1	Q13561	DCTN2_HUMAN	dynactin 2 (p50)	396					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|upper_aerodigestive_tract(2)	11						CCAGCTTCTTCATCCGTTCAT	0.478													58	39					0	0	1	0	0	T	57924490	C	T	57924490	3	4	7	1	0	0	0	0	1	0	0	0	4330	826	29	3	21	3	DCTN2	12	57924490	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		57924490	75927405	52	461										
HCFC2	29915	broad.mit.edu	37	chr12	104492131	104492131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ctgaaattagaaagagactcCttcaaatccagtggccacag	8	10	1	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:104492131C>T	ENST00000229330.4	+	13	1855	c.1751C>T	c.(1750-1752)cCt>cTt	p.P584L	HCFC2_ENST00000550335.1_3'UTR	NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	584	Fibronectin type-III 2.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						AAAGAGACTCCTTCAAATCCA	0.343													8	27					0	0	1	0	0	T	104492131	C	T	104492131	3	4	7	1	0	0	0	0	1	0	0	0	7033	681	24	3	1801	3	HCFC2	12	104492131	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	46567641	104492131	29359764	53	462										
EP400	57634	broad.mit.edu	37	chr12	132489700	132489700	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tcagtggccccggccgaagcCtgatggggaggacacaagcg	16	12	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:132489700C>T	ENST00000333577.4	+	14	3123	c.3014C>T	c.(3013-3015)cCt>cTt	p.P1005L	EP400_ENST00000389562.2_Missense_Mutation_p.P968L|EP400_ENST00000330386.6_Missense_Mutation_p.P969L|EP400_ENST00000389561.2_Missense_Mutation_p.P969L|EP400_ENST00000332482.4_Missense_Mutation_p.P932L			Q96L91	EP400_HUMAN	E1A binding protein p400	1005	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CGGCCGAAGCCTGATGGGGAG	0.567													6	7					0	0	1	0	0	T	132489700	C	T	132489700	3	4	7	1	0	0	0	0	1	0	0	0	5177	681	24	3	2949	3	EP400	12	132489700	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	27997569	132489700	1362195	54	463										
RB1	5925	broad.mit.edu	37	chr13	48881414	48881414	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tatgattattttcatttggtAggcttgagtttgaagaaaca	9	3	1	4			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr13:48881414A>G	ENST00000267163.4	+	2	275		c.e2-1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTCATTTGGTAGGCTTGAGTT	0.313		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			21	2					0	0	1	0	0	G	48881414	A	G	48881414	5	3	7	1	0	0	0	0	0	0	1	0	13149	434	15	4	142	4	RB1	13	48881414	Splice_Site	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08		48881414	66288464	55	464										
DCT	1638	broad.mit.edu	37	chr13	95114274	95114274	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gagcacccacctgaaactgaAggtagagttctggaagaagg	13	8	1	4			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr13:95114274A>T	ENST00000377028.5	-	5	1446	c.1033T>A	c.(1033-1035)Ttc>Atc	p.F345I	DCT_ENST00000446125.1_Missense_Mutation_p.F345I	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	345					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		CTGAAACTGAAGGTAGAGTTC	0.458													11	25					0	0	1	0	0	T	95114274	A	T	95114274	3	4	7	1	0	0	0	0	1	0	0	0	4327	72	3	4	649	4	DCT	13	95114274	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08	46232860	95114274	20055604	56	465										
TM9SF1	10548	broad.mit.edu	37	chr14	24679649	24679649	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttaacaactcctgggccaatTcctcctgctccagctcctct	5	17	1	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:24679649T>A	ENST00000556387.1	-	5	548	c.515A>T	c.(514-516)gAa>gTa	p.E172V	AL136419.6_ENST00000565988.1_RNA|CHMP4A_ENST00000542700.2_5'UTR|CHMP4A_ENST00000347519.6_Missense_Mutation_p.E215V|TM9SF1_ENST00000530611.1_Missense_Mutation_p.E172V			O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1	0					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				NS(1)|breast(4)|endometrium(3)|large_intestine(11)|lung(4)|ovary(1)	24				GBM - Glioblastoma multiforme(265;0.0183)		CTGGGCCAATTCCTCCTGCTC	0.483													106	141					0	0	1	0	0	A	24679649	T	A	24679649	3	1	7	1	0	0	0	0	1	0	0	0	16036	1783	62	4		4	TM9SF1	14	24679649	Missense_Mutation	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08		24679649	82669891	57	466										
KLHDC2	23588	broad.mit.edu	37	chr14	50249133	50249133	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gatgaaggagaagtaattgtTtttggtggatgtgccaacaa	13	3	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:50249133T>G	ENST00000298307.5	+	11	1863	c.1002T>G	c.(1000-1002)gtT>gtG	p.V334V	KLHDC2_ENST00000554589.1_Silent_p.V334V|KLHDC2_ENST00000557247.1_3'UTR	NM_014315.2	NP_055130.1	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	334						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(31;0.000959)|Breast(41;0.0117)					AAGTAATTGTTTTTGGTGGAT	0.403													16	42					0	0	1	0	0	G	50249133	T	G	50249133	2	3	7	1	0	0	0	0	0	0	0	1	8398	1828	64	4		4	KLHDC2	14	50249133	Silent	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	25569484	50249133	57100407	58	467										
PPP2R5E	5529	broad.mit.edu	37	chr14	63858584	63858584	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	atttcattaaccccctaataAcctaaaatgaaaaggagaaa	4	8	1	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:63858584A>G	ENST00000337537.3	-	10	1507	c.903_splice	c.e10-1	p.V302_splice	PPP2R5E_ENST00000553266.1_5'UTR|PPP2R5E_ENST00000422769.2_Splice_Site_p.V226_splice|PPP2R5E_ENST00000555899.1_Splice_Site_p.V302_splice	NM_006246.2	NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	302					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		CCCCCTAATAACCTAAAATGA	0.299													13	40					0	0	1	0	0	G	63858584	A	G	63858584	5	3	7	1	0	0	0	0	0	0	1	0	12444	57	2	4	518	4	PPP2R5E	14	63858584	Splice_Site	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08	13609451	63858584	43490956	59	468										
SERPINA6	866	broad.mit.edu	37	chr14	94770860	94770860	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cgcaagatgataggcttggaCgtcaggtttagggtgacccc	14	9	1	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:94770860C>T	ENST00000341584.3	-	5	1259	c.1113G>A	c.(1111-1113)acG>acA	p.T371T		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	371					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TAGGCTTGGACGTCAGGTTTA	0.522													36	19					0	0	1	0	0	T	94770860	C	T	94770860	2	4	7	1	0	0	0	0	0	0	0	1	14146	523	19	1		1	SERPINA6	14	94770860	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	30912276	94770860	12578680	60	469										
RTL1	388015	broad.mit.edu	37	chr14	101349485	101349485	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ccgggtagcaggctcatgccGtgcctctctagggcaatgca	13	13	2	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:101349485G>C	ENST00000534062.1	-	1	1699	c.1641C>G	c.(1639-1641)caC>caG	p.H547Q		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	547										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						GGCTCATGCCGTGCCTCTCTA	0.602													8	1					0	0	1	0	0	C	101349485	G	C	101349485	3	2	7	1	0	0	0	0	1	0	0	0	13775	1136	40	5	2439	5	RTL1	14	101349485	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	6578625	101349485	6000055	61	470										
CELF6	60677	broad.mit.edu	37	chr15	72608246	72608246	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttgagagcagagtcccgggcGcagtaggtgaggaaggcaca	17	8	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr15:72608246G>A	ENST00000287202.5	-	2	539	c.285C>T	c.(283-285)tgC>tgT	p.C95C	RP11-106M3.2_ENST00000379915.4_RNA|CELF6_ENST00000539635.1_5'UTR|RP11-106M3.3_ENST00000570175.1_RNA|CELF6_ENST00000567083.1_Silent_p.C95C	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	95	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						AGTCCCGGGCGCAGTAGGTGA	0.587													3	18					0	0	1	0	0	A	72608246	G	A	72608246	2	1	7	1	0	0	0	0	0	0	0	1	3242	1079	38	1		1	CELF6	15	72608246	Silent	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08		72608246	29923146	62	471										
CREBBP	1387	broad.mit.edu	37	chr16	3778746	3778746	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	acttggctgtgcgctgtttgAtgaaagctgccattagctgc	12	9	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:3778746A>G	ENST00000262367.5	-	31	7111	c.6302T>C	c.(6301-6303)aTc>aCc	p.I2101T	CREBBP_ENST00000382070.3_Missense_Mutation_p.I2063T	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2101					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCGCTGTTTGATGAAAGCTGC	0.612			"T, N, F, Mis, O"	"MLL, MORF, RUNXBP2"	"ALL, AML, DLBCL, B-NHL "		Rubinstein-Taybi syndrome						195	20					0	0	1	0	0	G	3778746	A	G	3778746	3	3	7	1	0	0	0	0	1	0	0	0	3884	333	12	4	1030	4	CREBBP	16	3778746	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08		3778746	86576007	63	472										
GTF3C1	2975	broad.mit.edu	37	chr16	27503992	27503992	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aactgtagcagccccatgtaGcacagcctctgaaggttctc	9	13	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:27503992G>A	ENST00000356183.4	-	18	2934	c.2919C>T	c.(2917-2919)tgC>tgT	p.C973C	GTF3C1_ENST00000561623.1_Silent_p.C973C	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	973						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GCCCCATGTAGCACAGCCTCT	0.512													83	80					0	0	1	0	0	A	27503992	G	A	27503992	2	1	7	1	0	0	0	0	0	0	0	1	6912	963	34	3		3	GTF3C1	16	27503992	Silent	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	23725246	27503992	62850761	64	473										
FAM65A	79567	broad.mit.edu	37	chr16	67579900	67579900	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aggatgaggacgtgcagactCgagtggctggctgcctggcc	17	10	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:67579900C>T	ENST00000540839.3	+	21	3713	c.3493C>T	c.(3493-3495)Cga>Tga	p.R1165*	FAM65A_ENST00000379312.3_Nonsense_Mutation_p.R1150*|FAM65A_ENST00000428437.2_Nonsense_Mutation_p.R1160*|FAM65A_ENST00000422602.2_Nonsense_Mutation_p.R1166*|FAM65A_ENST00000042381.4_Nonsense_Mutation_p.R1146*			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	1150						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CGTGCAGACTCGAGTGGCTGG	0.657													57	37					0	0	1	0	0	T	67579900	C	T	67579900	4	4	7	1	0	0	0	0	0	1	0	0	5633	876	31	1	3510	1	FAM65A	16	67579900	Nonsense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	40075908	67579900	22774853	65	474										
PHLPP2	23035	broad.mit.edu	37	chr16	71701133	71701133	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cctcgtgagtgcattatgctGaagatccagcacctcgaggg	12	11	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:71701133G>A	ENST00000393524.2	-	11	2465	c.1732C>T	c.(1732-1734)Cag>Tag	p.Q578*	PHLPP2_ENST00000360429.3_Nonsense_Mutation_p.Q578*|PHLPP2_ENST00000356272.3_Nonsense_Mutation_p.Q578*|PHLPP2_ENST00000568954.1_Nonsense_Mutation_p.Q578*|PHLPP2_ENST00000567016.1_Nonsense_Mutation_p.Q613*			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	652						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						GCATTATGCTGAAGATCCAGC	0.463													24	43					0	0	1	0	0	A	71701133	G	A	71701133	4	1	7	1	0	0	0	0	0	1	0	0	11902	1299	45	3	2271	3	PHLPP2	16	71701133	Nonsense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	4121233	71701133	18653620	66	475										
CNTNAP4	85445	broad.mit.edu	37	chr16	76587181	76587181	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgtttctttgaatttctagaAcacagtgatgtggaccagga	10	6	2	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:76587181A>G	ENST00000307431.8	+	23	3826	c.3439_splice	c.e23-1	p.E1147_splice	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Splice_Site_p.E1099_splice|CNTNAP4_ENST00000476707.1_Splice_Site_p.E1151_splice|CNTNAP4_ENST00000478060.1_Splice_Site_p.E1075_splice	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1148	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AATTTCTAGAACACAGTGATG	0.478													6	8					0	0	1	0	0	G	76587181	A	G	76587181	5	3	7	1	0	0	0	0	0	0	1	0	3672	57	2	4	3543	4	CNTNAP4	16	76587181	Splice_Site	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08	4886048	76587181	13767572	67	476										
FAM92B	339145	broad.mit.edu	37	chr16	85135890	85135890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aatacacctccaccgctttgGcatggaaaaccatctcaata	5	13	1	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:85135890G>A	ENST00000539556.1	-	7	736	c.581C>T	c.(580-582)gCc>gTc	p.A194V		NM_198491.1	NP_940893.1	Q6ZTR7	FA92B_HUMAN	family with sequence similarity 92, member B	194										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	16						CACCGCTTTGGCATGGAAAAC	0.473													12	35					0	0	1	0	0	A	85135890	G	A	85135890	3	1	7	1	0	0	0	0	1	0	0	0	5685	1203	42	3	345	3	FAM92B	16	85135890	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	8548709	85135890	5218863	68	477										
TP53	7157	broad.mit.edu	37	chr17	7577097	7577097	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ctcttcctctgtgcgccggtCtctcccaggacaggcacaaa	9	16	3	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr17:7577097C>T	ENST00000420246.2	-	8	973	c.841G>A	c.(841-843)Gac>Aac	p.D281N	TP53_ENST00000269305.4_Missense_Mutation_p.D281N|TP53_ENST00000455263.2_Missense_Mutation_p.D281N|TP53_ENST00000359597.4_Missense_Mutation_p.D281N|TP53_ENST00000445888.2_Missense_Mutation_p.D281N|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	281	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		D -> A (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> Y (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281N(25)|p.D281H(19)|p.D281Y(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.D281>AGPY(2)|p.A276_R283delACPGRDRR(1)|p.D281R(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.D281_R282delDR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGCGCCGGTCTCTCCCAGGA	0.547		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	5					0	0	1	0	0	T	7577097	C	T	7577097	3	4	7	1	0	0	0	0	1	0	0	0	16441	913	32	3	445	3	TP53	17	7577097	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		7577097	73618113	69	478										
GAST	2520	broad.mit.edu	37	chr17	39872040	39872040	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	acctcctcagacccgtccaaGaagcagggaccatggctgga	11	14	1	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr17:39872040G>C	ENST00000329402.3	+	3	289	c.222G>C	c.(220-222)aaG>aaC	p.K74N	JUP_ENST00000540235.1_Intron	NM_000805.4	NP_000796.1	P01350	GAST_HUMAN	gastrin	74						extracellular region	hormone activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			ACCCGTCCAAGAAGCAGGGAC	0.557													23	114					0	0	1	0	0	C	39872040	G	C	39872040	3	2	7	1	0	0	0	0	1	0	0	0	6291	933	33	2	228	2	GAST	17	39872040	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	32294943	39872040	41323170	70	479										
PTPRM	5797	broad.mit.edu	37	chr18	8380347	8380347	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cagcatcctttgccaaacacAgtgaaagacttttggagact	8	10	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:8380347A>C	ENST00000332175.8	+	27	4838	c.3801A>C	c.(3799-3801)acA>acC	p.T1267T	PTPRM_ENST00000444013.1_Silent_p.T1054T|PTPRM_ENST00000400053.4_Silent_p.T1205T|PTPRM_ENST00000400060.4_Silent_p.T1281T|PTPRM_ENST00000580170.1_Silent_p.T1280T	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1267	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				TGCCAAACACAGTGAAAGACT	0.443													16	84					0	0	1	0	0	C	8380347	A	C	8380347	2	2	7	1	0	0	0	0	0	0	0	1	12857	175	7	4		4	PTPRM	18	8380347	Silent	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08		8380347	69696901	71	480										
APCDD1	147495	broad.mit.edu	37	chr18	10487757	10487757	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aactacctcacacggagtacGagatcttcaaaatggaacag	8	10	3	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:10487757G>A	ENST00000355285.4	+	5	1621	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K		NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	423					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		CACGGAGTACGAGATCTTCAA	0.627													27	167					0	0	1	0	0	A	10487757	G	A	10487757	3	1	7	1	0	0	0	0	1	0	0	0	761	1059	37	1	1285	1	APCDD1	18	10487757	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	2107410	10487757	67589491	72	481										
SLC14A2	8170	broad.mit.edu	37	chr18	43248429	43248429	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgttgctacccgtcatcatcAtgtccatgtcttggtaagtt	8	10	4	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:43248429A>T	ENST00000255226.6	+	15	2839	c.2023A>T	c.(2023-2025)Atg>Ttg	p.M675L	SLC14A2_ENST00000589658.1_Missense_Mutation_p.M152L|SLC14A2_ENST00000586448.1_Missense_Mutation_p.M675L	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	675						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CGTCATCATCATGTCCATGTC	0.498													16	88					0	0	1	0	0	T	43248429	A	T	43248429	3	4	7	1	0	0	0	0	1	0	0	0	14451	217	8	4	2077	4	SLC14A2	18	43248429	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08	32760672	43248429	34828819	73	482										
MUC16	94025	broad.mit.edu	37	chr19	9073782	9073782	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	atggttctgagctgactgggAgagtggaatgcagtacatgt	15	5	1	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:9073782A>G	ENST00000397910.4	-	3	13867	c.13664T>C	c.(13663-13665)cTc>cCc	p.L4555P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4557	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTGACTGGGAGAGTGGAATG	0.493													13	18					0	0	1	0	0	G	9073782	A	G	9073782	3	3	7	1	0	0	0	0	1	0	0	0	10020	304	11	4	30187	4	MUC16	19	9073782	Missense_Mutation	SNP	A	TCGA-N5-A4RN-01A-12D-A28R-08		9073782	50055201	74	483										
ATP4A	495	broad.mit.edu	37	chr19	36044045	36044045	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	agccctcctgggccattgccGtgaagtagtcagtgaagcca	12	12	1	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:36044045G>A	ENST00000262623.3	-	18	2673	c.2645C>T	c.(2644-2646)aCg>aTg	p.T882M		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	882					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGCCATTGCCGTGAAGTAGTC	0.602													4	132					0	0	1	0	0	A	36044045	G	A	36044045	3	1	7	1	0	0	0	0	1	0	0	0	1144	1145	40	1	482	1	ATP4A	19	36044045	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	26970263	36044045	23084938	75	484										
SUPT5H	6829	broad.mit.edu	37	chr19	39962347	39962347	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ttgtctgcaagacccgccacCtggtgctggctgggggctca	14	13	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:39962347C>T	ENST00000599117.1	+	21	2294	c.1927C>T	c.(1927-1929)Ctg>Ttg	p.L643L	SUPT5H_ENST00000359191.6_Silent_p.L639L|SUPT5H_ENST00000402194.2_Silent_p.L639L|SUPT5H_ENST00000598725.1_Silent_p.L643L|SUPT5H_ENST00000432763.2_Silent_p.L643L			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	643					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GACCCGCCACCTGGTGCTGGC	0.602													10	47					0	0	1	0	0	T	39962347	C	T	39962347	2	4	7	1	0	0	0	0	0	0	0	1	15454	680	24	3		3	SUPT5H	19	39962347	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	3918302	39962347	19166636	76	485										
SPTBN4	57731	broad.mit.edu	37	chr19	41072112	41072112	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	caggaggcggtggtggctgaTgcctggctgacagcccagga	18	10	0	2			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:41072112T>C	ENST00000352632.3	+	30	6269	c.6183T>C	c.(6181-6183)gaT>gaC	p.D2061D	SPTBN4_ENST00000338932.3_Silent_p.D2061D|SPTBN4_ENST00000392025.1_Silent_p.D804D|SPTBN4_ENST00000598249.1_Silent_p.D2061D			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2061					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGTGGCTGATGCCTGGCTGA	0.667													4	4					0	0	1	0	0	C	41072112	T	C	41072112	2	2	7	1	0	0	0	0	0	0	0	1	15176	1461	51	4		4	SPTBN4	19	41072112	Silent	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08	1109765	41072112	18056871	77	486										
ADCK4	79934	broad.mit.edu	37	chr19	41220036	41220036	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cgttctcgagagcggtcactCagctgggaaatggggacaag	15	9	3	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:41220036C>G	ENST00000324464.3	-	4	526	c.225G>C	c.(223-225)ctG>ctC	p.L75L	ADCK4_ENST00000243583.6_Silent_p.L75L|ADCK4_ENST00000450541.1_Silent_p.L75L	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	75						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			AGCGGTCACTCAGCTGGGAAA	0.617													4	89					0	0	1	0	0	G	41220036	C	G	41220036	2	3	7	1	0	0	0	0	0	0	0	1	289	813	29	2		2	ADCK4	19	41220036	Silent	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	147924	41220036	17908947	78	487										
PTPRA	0	broad.mit.edu	37	chr20	2985712	2985712	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aacctttcaggctctccctgCatgtcctatccaggccacct	6	17	2	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr20:2985712C>T	ENST00000216877.6	+	9	1122	c.722C>T	c.(721-723)gCa>gTa	p.A241V	PTPRA_ENST00000425918.2_Missense_Mutation_p.A261V|PTPRA_ENST00000399903.2_Missense_Mutation_p.A250V|PTPRA_ENST00000380393.3_Missense_Mutation_p.A250V|PTPRA_ENST00000358719.4_Missense_Mutation_p.A106V|PTPRA_ENST00000318266.5_Missense_Mutation_p.A241V|PTPRA_ENST00000356147.3_Missense_Mutation_p.A241V	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	250	Tyrosine-protein phosphatase 1.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCTCTCCCTGCATGTCCTATC	0.438													5	244					0	0	1	0	0	T	2985712	C	T	2985712	3	4	7	1	0	0	0	0	1	0	0	0	12846	710	25	3	775	3	PTPRA	20	2985712	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08		2985712	60039808	79	488										
CDH22	64405	broad.mit.edu	37	chr20	44856148	44856148	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gccccgccctgcccctcaccGgtcttggggtccacggtgaa	12	18	2	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr20:44856148G>T	ENST00000372262.3	-	3	1069	c.670_splice	c.e3+1	p.T223_splice	CDH22_ENST00000537909.1_Splice_Site_p.T223_splice	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	223	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				gccccTCACCGGTCTTGGGGT	0.716													6	20					0.00198382	0.0020716	1	1	0	T	44856148	G	T	44856148	5	4	7	1	0	0	0	0	0	0	1	0	3129	1130	39	5	1853	5	CDH22	20	44856148	Splice_Site	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	41870436	44856148	18169372	80	489										
BAGE2	85319	broad.mit.edu	37	chr21	11046071	11046078	+	RNA	DEL	AAAAAAAC	AAAAAAAC	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	acatacttcagcacaacttaAaaaaaacaaagttattcgct					rs144620563		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11046071_11046078delAAAAAAAC	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCACAACTTAAAAAAAACAAAGTTATTC	0.264													2	4	---	---	---	---						-	11046078	AAAAAAAC	-	11046071	6	5	7	0	1	1	0	1	0	0	0	0	1290	29	1	0		0	BAGE2	21	11046071	RNA	DEL	AAAAAAAC	TCGA-N5-A4RN-01A-12D-A28R-08		11046071	37083824	81	490										
BAGE2	85319	broad.mit.edu	37	chr21	11065194	11065197	+	RNA	DEL	AGAG	AGAG	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aatcctgtgagaccttaaacAgagagcacagttgagcctgc							TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11065194_11065197delAGAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gaccttaaacagagagcacagttg	0.426													4	8	---	---	---	---						-	11065197	AGAG	-	11065194	6	5	7	0	1	1	0	1	0	0	0	0	1290	203	7	0		0	BAGE2	21	11065194	RNA	DEL	AGAG	TCGA-N5-A4RN-01A-12D-A28R-08	19123	11065194	37064701	82	491										
BAGE2	85319	broad.mit.edu	37	chr21	11072706	11072706	+	RNA	DEL	A	A	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gagaagtaaatgaactgattAaaaaaaaaaaaaaacagtgg					rs150219169		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11072706delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tgaactgattaaaaaaaaaaa	0.393													4	6	---	---	---	---						-	11072706	A	-	11072706	6	5	7	0	1	1	0	1	0	0	0	0	1290	377	13	0		0	BAGE2	21	11072706	RNA	DEL	A	TCGA-N5-A4RN-01A-12D-A28R-08	7512	11072706	37057189	83	492	2	2								
BAGE2	85319	broad.mit.edu	37	chr21	11072716	11072717	+	RNA	INS	-	-	C													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gaactgattaaaaaaaaaaaINSaaaacagtggccaggtgcgg					rs80212457	by1000genomes	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11072716_11072717insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aaaaaaaaaaaaaaacagtggc	0.421													6	6	---	---	---	---						C	11072717	-	C	11072716	6	5	7	0	1	1	1	0	0	0	0	0	1290	29	1	0		0	BAGE2	21	11072716	RNA	INS	-	TCGA-N5-A4RN-01A-12D-A28R-08	10	11072716	37057179	84	493	2	2								
BAGE2	85319	broad.mit.edu	37	chr21	11080670	11080673	+	RNA	DEL	AGAG	AGAG	-													0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	aagtataaaagtaaagacacAgagagagagacttcaaaaag					rs3954670		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11080670_11080673delAGAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAAAGACACAGAGAGAGAGACTT	0.485													5	4	---	---	---	---						-	11080673	AGAG	-	11080670	6	5	7	0	1	1	0	1	0	0	0	0	1290	203	7	0		0	BAGE2	21	11080670	RNA	DEL	AGAG	TCGA-N5-A4RN-01A-12D-A28R-08	7954	11080670	37049225	85	494										
DEPDC5	9681	broad.mit.edu	37	chr22	32232998	32232998	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	cctgtagtgccaggcttctgTtgcacagttggagtggactg	14	9	1	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr22:32232998T>C	ENST00000400246.1	+	26	2353	c.2211T>C	c.(2209-2211)tgT>tgC	p.C737C	DEPDC5_ENST00000382105.2_Silent_p.C659C|DEPDC5_ENST00000382112.3_Silent_p.C728C|DEPDC5_ENST00000382111.2_Silent_p.C737C|DEPDC5_ENST00000400249.2_Silent_p.C728C|DEPDC5_ENST00000400248.1_Silent_p.C728C|DEPDC5_ENST00000266091.3_Silent_p.C737C|DEPDC5_ENST00000535622.1_Silent_p.C659C			O75140	DEPD5_HUMAN	DEP domain containing 5	728					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CAGGCTTCTGTTGCACAGTTG	0.577													30	36					0	0	1	0	0	C	32232998	T	C	32232998	2	2	7	1	0	0	0	0	0	0	0	1	4470	1731	60	4		4	DEPDC5	22	32232998	Silent	SNP	T	TCGA-N5-A4RN-01A-12D-A28R-08		32232998	19071568	86	495										
RPS6KA6	27330	broad.mit.edu	37	chrX	83403058	83403058	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	ctaattttctaccttttaaaGaggctttttttaacaccttc	3	9	1	1			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrX:83403058G>A	ENST00000262752.2	-	4	339	c.332C>T	c.(331-333)tCt>tTt	p.S111F	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.S111F	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	111	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.S111F(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ACCTTTTAAAGAGGCTTTTTT	0.299													9	14					0	0	1	0	0	A	83403058	G	A	83403058	3	1	7	1	0	0	0	0	1	0	0	0	13706	942	33	3	1981	3	RPS6KA6	23	83403058	Missense_Mutation	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08		83403058	71867502	87	496										
RAB33A	9363	broad.mit.edu	37	chrX	129306073	129306073	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	tgggccatgggagcctgcagCccgcctcggccgctggcctg	16	16	0	0			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrX:129306073C>A	ENST00000257017.4	+	1	451	c.37C>A	c.(37-39)Ccc>Acc	p.P13T		NM_004794.2	NP_004785.1	Q14088	RB33A_HUMAN	RAB33A, member RAS oncogene family	13					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(5)	11						GAGCCTGCAGCCCGCCTCGGC	0.647													19	18					5.35267e-07	5.84828e-07	1	1	0	A	129306073	C	A	129306073	3	1	7	1	0	0	0	0	1	0	0	0	12973	739	26	5	39	5	RAB33A	23	129306073	Missense_Mutation	SNP	C	TCGA-N5-A4RN-01A-12D-A28R-08	45903015	129306073	25964487	88	497										
HMGB3	3149	broad.mit.edu	37	chrX	150156360	150156360	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0795454545454545	7	1	1.2277430591128	3.77092511013216	0.815335158947494	1	1	0	gaagaggaggaggaagaagaGgaggaggaggaggaggagga	24	0	0	3			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443													3	31					0	0	1	0	0	A	150156360	G	A	150156360	2	1	7	1	0	0	0	0	0	0	0	1	7267	991	35	3		3	HMGB3	23	150156360	Silent	SNP	G	TCGA-N5-A4RN-01A-12D-A28R-08	20850287	150156360	5114200	89	498										
CASZ1	54897	broad.mit.edu	37	chr1	10699459	10699459	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tgggaggcccgggcgcggggCcctctgccgcgggctcgccg	20	16	1	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr1:10699459C>T	ENST00000377022.3	-	21	5137	c.4820G>A	c.(4819-4821)gGc>gAc	p.G1607D	RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1607					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGGCGCGGGGCCCTCTGCCGC	0.746													4	6					0	0	1	0	0	T	10699459	C	T	10699459	3	4	8	1	0	0	0	0	1	0	0	0	2703	739	26	3	463	3	CASZ1	1	10699459	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		10699459	238551162	1	499										
B4GALT2	8704	broad.mit.edu	37	chr1	44447007	44447009	+	In_Frame_Del	DEL	AGC	AGC	-													0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	atgccctccacccagctgctAgcagcagcagcagcagcagc					rs72406230		TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr1:44447007_44447009delAGC	ENST00000356836.6	+	2	965_967	c.175_177delAGC	c.(175-177)del	p.S65del	B4GALT2_ENST00000309519.7_In_Frame_Del_p.S94del|B4GALT2_ENST00000372324.1_In_Frame_Del_p.S65del|B4GALT2_ENST00000434555.2_In_Frame_Del_p.LA7del	NM_001005417.2|NM_030587.2	NP_001005417.1|NP_085076.2	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	65					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CCCAGCTGCTagcagcagcagca	0.685													7	124	---	---	---	---						-	44447009	AGC	-	44447007	7	5	8	1	0	1	0	1	0	0	0	0	1269	420	15	0	177	0	B4GALT2	1	44447007	In_Frame_Del	DEL	AGC	TCGA-N5-A4RO-01A-11D-A28R-08	33747548	44447007	204803614	2	500										
OMA1	115209	broad.mit.edu	37	chr1	59004951	59004951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tctagcagcagactgcaatcCacagatgaagctcatttttt	7	10	2	3			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr1:59004951C>T	ENST00000371226.3	-	2	129	c.16G>A	c.(16-18)Gga>Aga	p.G6R	OMA1_ENST00000467063.1_Intron|DAB1_ENST00000485760.1_Intron|OMA1_ENST00000358603.2_Missense_Mutation_p.G6R	NM_145243.3	NP_660286.1	Q96E52	OMA1_HUMAN	OMA1 zinc metallopeptidase	6					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			NS(1)|breast(1)|large_intestine(6)|liver(2)|lung(6)|prostate(1)|skin(1)	18	all_cancers(7;6.54e-05)					GACTGCAATCCACAGATGAAG	0.363													12	25					0	0	1	0	0	T	59004951	C	T	59004951	3	4	8	1	0	0	0	0	1	0	0	0	10911	603	21	3	1590	3	OMA1	1	59004951	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	14557944	59004951	190245670	3	501										
SETDB1	9869	broad.mit.edu	37	chr1	150933333	150933333	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tgctacccggaggcagacccGgggccagaaagagaacggac	15	12	0	3			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr1:150933333G>A	ENST00000271640.5	+	16	2985	c.2795G>A	c.(2794-2796)cGg>cAg	p.R932Q	SETDB1_ENST00000459773.1_3'UTR|SETDB1_ENST00000368969.4_Missense_Mutation_p.R932Q	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	932	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGGCAGACCCGGGGCCAGAAA	0.532													41	65					0	0	1	0	0	A	150933333	G	A	150933333	3	1	8	1	0	0	0	0	1	0	0	0	14191	1116	39	1	2853	1	SETDB1	1	150933333	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	91928382	150933333	98317288	4	502										
KPRP	448834	broad.mit.edu	37	chr1	152732884	152732884	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gcagctgttccccaccaagaCgttttgagccctgctccagc	9	16	0	2	rs148079077		TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr1:152732884C>T	ENST00000368773.1	+	2	878	c.820C>T	c.(820-822)Cgt>Tgt	p.R274C	KPRP_ENST00000606109.1_Missense_Mutation_p.R274C	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	274	Pro-rich.					cytoplasm		p.R274C(1)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCACCAAGACGTTTTGAGCC	0.592													63	39					0	0	1	0	0	T	152732884	C	T	152732884	3	4	8	1	0	0	0	0	1	0	0	0	8478	536	19	1	822	1	KPRP	1	152732884	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	1799551	152732884	96517737	5	503										
CACNA1E	777	broad.mit.edu	37	chr1	181702035	181702035	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ggagtcctcttcagcctcccGgagcaggtctgccagccagg	13	15	3	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr1:181702035G>A	ENST00000526775.1	+	19	2921	c.2756G>A	c.(2755-2757)cGg>cAg	p.R919Q	CACNA1E_ENST00000367567.4_Missense_Mutation_p.R545Q|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R870Q|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R938Q|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R889Q|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R919Q|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R938Q	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	938					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.R938Q(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCAGCCTCCCGGAGCAGGTCT	0.642													46	90					0	0	1	0	0	A	181702035	G	A	181702035	3	1	8	1	0	0	0	0	1	0	0	0	2560	1116	39	1	2891	1	CACNA1E	1	181702035	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	28969151	181702035	67548586	6	504										
C2orf71	388939	broad.mit.edu	37	chr2	29293880	29293880	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	atggggagggaatcgagaaaGgggggcttgcttctgggtgc	20	5	1	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr2:29293880G>A	ENST00000331664.5	-	1	3247	c.3248C>T	c.(3247-3249)cCt>cTt	p.P1083L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1083	Pro-rich.				response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						AATCGAGAAAGGGGGGCTTGC	0.602													44	96					0	0	1	0	0	A	29293880	G	A	29293880	3	1	8	1	0	0	0	0	1	0	0	0	2205	1000	35	3	626	3	C2orf71	2	29293880	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		29293880	213905493	7	505										
RTN4	57142	broad.mit.edu	37	chr2	55276891	55276892	+	Frame_Shift_Del	DEL	CG	CG	-													0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cggcactcacccactgagccCgaggagcccctgcgcttggg							TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr2:55276891_55276892delCG	ENST00000337526.6	-	1	788_789	c.545_546delCG	c.(544-546)tfs	p.S182fs	RTN4_ENST00000402434.2_Frame_Shift_Del_p.S154fs|RTN4_ENST00000394611.2_Intron|RTN4_ENST00000354474.6_Intron|RTN4_ENST00000317610.7_Frame_Shift_Del_p.S182fs|RTN4_ENST00000404909.1_Intron|RTN4_ENST00000357732.4_Frame_Shift_Del_p.S182fs	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	182					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						CCACTGAGCCCGAGGAGCCCCT	0.757													2	4	---	---	---	---						-	55276892	CG	-	55276891	7	5	8	1	0	1	0	1	0	0	0	0	13779	639	23	0	3106	0	RTN4	2	55276891	Frame_Shift_Del	DEL	CG	TCGA-N5-A4RO-01A-11D-A28R-08	25983011	55276891	187922482	8	506										
CHRNA1	1134	broad.mit.edu	37	chr2	175624069	175624069	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gctaagttacctgtttcagaCgcacattggttgtcacgatc	9	10	2	1	rs147488907	byFrequency	TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr2:175624069C>A	ENST00000348749.5	-	3	301	c.224G>T	c.(223-225)cGt>cTt	p.R75L	CHRNA1_ENST00000409219.1_Missense_Mutation_p.R75L|CHRNA1_ENST00000261007.5_Missense_Mutation_p.R75L|CHRNA1_ENST00000409323.1_Missense_Mutation_p.R75L|CHRNA1_ENST00000409542.1_Missense_Mutation_p.R75L|AC018890.6_ENST00000442996.1_RNA	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	75					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						CTGTTTCAGACGCACATTGGT	0.443													7	71					2.7689e-08	3.02351e-08	1	1	0	A	175624069	C	A	175624069	3	1	8	1	0	0	0	0	1	0	0	0	3403	536	19	5	1256	5	CHRNA1	2	175624069	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	120347178	175624069	67575304	9	507										
TTN	7273	broad.mit.edu	37	chr2	179594664	179594664	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	actgggcttcttaatgaattGaggaggttctaaagatggaa	12	4	2	3			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr2:179594664G>C	ENST00000589042.1	-	63	18540	c.18316C>G	c.(18316-18318)Caa>Gaa	p.Q6106E	TTN_ENST00000591111.1_Missense_Mutation_p.Q5789E|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.Q4862E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5789	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAATGAATTGAGGAGGTTCT	0.438													9	18					0	0	1	0	0	C	179594664	G	C	179594664	3	2	8	1	0	0	0	0	1	0	0	0	16796	1299	45	2	86413	2	TTN	2	179594664	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	3970595	179594664	63604709	10	508										
INO80D	54891	broad.mit.edu	37	chr2	206921004	206921004	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tgcagtcggcttatacatgaGaagtgtggagagaaggctgt	15	5	0	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr2:206921004G>C	ENST00000403263.1	-	4	1286	c.882C>G	c.(880-882)ttC>ttG	p.F294L		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	294					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						TTATACATGAGAAGTGTGGAG	0.517													25	60					0	0	1	0	0	C	206921004	G	C	206921004	3	2	8	1	0	0	0	0	1	0	0	0	7792	933	33	2	2233	2	INO80D	2	206921004	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	27326340	206921004	36278369	11	509										
DYTN	391475	broad.mit.edu	37	chr2	207569605	207569605	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tagttttctcaaaacccttcGagtcatgcgtggcccagaat	8	11	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr2:207569605G>A	ENST00000452335.2	-	5	561	c.445C>T	c.(445-447)Cga>Tga	p.R149*	DYTN_ENST00000477734.1_5'UTR	NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	149						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		AAAACCCTTCGAGTCATGCGT	0.358													17	11					0	0	1	0	0	A	207569605	G	A	207569605	4	1	8	1	0	0	0	0	0	1	0	0	4887	1066	37	1	1323	1	DYTN	2	207569605	Nonsense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	648601	207569605	35629768	12	510										
CLASP2	23122	broad.mit.edu	37	chr3	33592874	33592874	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gagtttctatgtatttaaggAtagcaaccttcacctgcaga	8	8	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr3:33592874A>G	ENST00000399362.4	-	30	3397	c.3044T>C	c.(3043-3045)aTc>aCc	p.I1015T	CLASP2_ENST00000539981.1_Missense_Mutation_p.I785T|CLASP2_ENST00000468888.2_Missense_Mutation_p.I1016T|CLASP2_ENST00000461133.3_Missense_Mutation_p.I775T|CLASP2_ENST00000359576.5_Missense_Mutation_p.I1007T|CLASP2_ENST00000307312.7_Missense_Mutation_p.I497T|CLASP2_ENST00000480013.1_Missense_Mutation_p.I795T	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	1017										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						GTATTTAAGGATAGCAACCTT	0.408													4	30					0	0	1	0	0	G	33592874	A	G	33592874	3	3	8	1	0	0	0	0	1	0	0	0	3478	333	12	4	1537	4	CLASP2	3	33592874	Missense_Mutation	SNP	A	TCGA-N5-A4RO-01A-11D-A28R-08		33592874	164429556	13	511										
UQCRC1	7384	broad.mit.edu	37	chr3	48637920	48637920	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	agctgtaggactcaccatctAgatgagataccagggcattt	10	9	2	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr3:48637920A>T	ENST00000203407.5	-	10	1624	c.1208T>A	c.(1207-1209)cTa>cAa	p.L403Q		NM_003365.2	NP_003356.2	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	403					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	CTCACCATCTAGATGAGATAC	0.567													20	1					0	0	1	0	0	T	48637920	A	T	48637920	3	4	8	1	0	0	0	0	1	0	0	0	17078	420	15	4	250	4	UQCRC1	3	48637920	Missense_Mutation	SNP	A	TCGA-N5-A4RO-01A-11D-A28R-08	15045046	48637920	149384510	14	512										
B4GALT4	8702	broad.mit.edu	37	chr3	118931403	118931403	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	aaaagacccagggtcatgcaCcaaaccagaaatccactgtg	8	12	1	2	rs72655939	byFrequency	TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr3:118931403C>G	ENST00000483209.1	-	8	1669	c.1028G>C	c.(1027-1029)gGt>gCt	p.G343A	B4GALT4_ENST00000471675.1_Intron|B4GALT4_ENST00000359213.3_Missense_Mutation_p.G343A|B4GALT4_ENST00000393765.2_Missense_Mutation_p.G343A|B4GALT4_ENST00000467604.1_3'UTR			O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4	343					membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(6)|skin(2)|stomach(2)	14				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)	GGGTCATGCACCAAACCAGAA	0.383													20	55					0	0	1	0	0	G	118931403	C	G	118931403	3	3	8	1	0	0	0	0	1	0	0	0	1271	507	18	5	10	5	B4GALT4	3	118931403	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	70293483	118931403	79091027	15	513										
PIK3CA	5290	broad.mit.edu	37	chr3	178952119	178952119	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	acaacaaaaatggattggatCttccacacaattaaacagca	5	9	1	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr3:178952119C>G	ENST00000263967.3	+	21	3331	c.3174C>G	c.(3172-3174)atC>atG	p.I1058M		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1058	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGGATTGGATCTTCCACACAA	0.398		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			32	47					0	0	1	0	0	G	178952119	C	G	178952119	3	3	8	1	0	0	0	0	1	0	0	0	11960	903	32	2	3252	2	PIK3CA	3	178952119	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	60020716	178952119	19070311	16	514										
NDUFB5	4711	broad.mit.edu	37	chr3	179332847	179332847	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	aggcgttttttgaagttattGgtaagtttaaattttttgtt	9	1	0	1	rs11539675		TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr3:179332847G>A	ENST00000259037.3	+	2	327	c.213_splice	c.e2+1	p.L71_splice	NDUFB5_ENST00000472629.1_Intron|NDUFB5_ENST00000493866.1_Intron|NDUFB5_ENST00000473500.1_Intron	NM_002492.3	NP_002483.1	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	71					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|lung(6)|skin(1)	8	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	TGAAGTTATTGGTAAGTTTAA	0.318													15	39					0	0	1	0	0	A	179332847	G	A	179332847	5	1	8	1	0	0	0	0	0	0	1	0	10330	1362	47	3	219	3	NDUFB5	3	179332847	Splice_Site	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	380728	179332847	18689583	17	515										
CTBP1	1487	broad.mit.edu	37	chr4	1232004	1232004	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tcctgcgtggactgcgcgtcGcagaaggccacagtggccac	14	14	0	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr4:1232004G>A	ENST00000510568.1	-	2	720	c.129C>T	c.(127-129)tgC>tgT	p.C43C	CTBP1_ENST00000515690.1_5'UTR|CTBP1_ENST00000290921.6_Silent_p.C54C|CTBP1_ENST00000382952.3_Silent_p.C43C			Q13363	CTBP1_HUMAN	C-terminal binding protein 1	54	Interaction with GLIS2 1 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		ACTGCGCGTCGCAGAAGGCCA	0.672													4	125					0	0	1	0	0	A	1232004	G	A	1232004	2	1	8	1	0	0	0	0	0	0	0	1	4021	1079	38	1		1	CTBP1	4	1232004	Silent	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		1232004	189922272	18	516										
FBXW7	0	broad.mit.edu	37	chr4	153249510	153249510	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tcatttgtgatgaccatactCcacctgtatgtcccactaat	5	12	1	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr4:153249510C>A	ENST00000281708.4	-	9	2497	c.1268G>T	c.(1267-1269)gGa>gTa	p.G423V	FBXW7_ENST00000393956.3_Missense_Mutation_p.G247V|FBXW7_ENST00000603841.1_Missense_Mutation_p.G423V|FBXW7_ENST00000263981.5_Missense_Mutation_p.G343V|FBXW7_ENST00000296555.5_Missense_Mutation_p.G305V|FBXW7_ENST00000603548.1_Missense_Mutation_p.G423V	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	423					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.G423V(7)|p.G343V(2)|p.G305V(2)|p.G184V(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGACCATACTCCACCTGTATG	0.373			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								47	61					7.88023e-25	8.80732e-25	1	1	0	A	153249510	C	A	153249510	3	1	8	1	0	0	0	0	1	0	0	0	5801	855	30	2	871	2	FBXW7	4	153249510	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	152017506	153249510	37904766	19	517										
CYFIP2	26999	broad.mit.edu	37	chr5	156712414	156712414	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	aagatgccctgtccaacgtgGacctgcttgaagagcttccc	10	13	0	3			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr5:156712414G>A	ENST00000347377.6	+	2	474	c.43G>A	c.(43-45)Gac>Aac	p.D15N	CYFIP2_ENST00000541131.1_Missense_Mutation_p.D15N|CYFIP2_ENST00000522463.1_Missense_Mutation_p.D15N|CYFIP2_ENST00000521420.1_Missense_Mutation_p.D15N|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000377576.3_Missense_Mutation_p.D15N|CYFIP2_ENST00000318218.6_Missense_Mutation_p.D15N	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	15					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCCAACGTGGACCTGCTTGA	0.537													6	4					0	0	1	0	0	A	156712414	G	A	156712414	3	1	8	1	0	0	0	0	1	0	0	0	4161	1174	41	3	45	3	CYFIP2	5	156712414	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		156712414	24202846	20	518										
RGS14	10636	broad.mit.edu	37	chr5	176793982	176793982	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	accgtcaggcctggcttggcGaggaggtgctggccgagccc	17	13	1	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr5:176793982G>A	ENST00000408923.3	+	5	618	c.430G>A	c.(430-432)Gag>Aag	p.E144K		NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	144	RGS.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGCTTGGCGAGGAGGTGCT	0.637													34	59					0	0	1	0	0	A	176793982	G	A	176793982	3	1	8	1	0	0	0	0	1	0	0	0	13346	1059	37	1	448	1	RGS14	5	176793982	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	20081568	176793982	4121278	21	519										
HIST1H3F	8968	broad.mit.edu	37	chr6	26250542	26250542	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gagccccaccaggtaagcctCgcaggcctcctgcagcgcca	11	18	0	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr6:26250542C>G	ENST00000446824.2	-	1	293	c.292G>C	c.(292-294)Gag>Cag	p.E98Q		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.E98K(1)		lung(6)|urinary_tract(1)	7						AGGTAAGCCTCGCAGGCCTCC	0.602											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	18					0	0	1	0	0	G	26250542	C	G	26250542	3	3	8	1	0	0	0	0	1	0	0	0	7200	893	31	2	122	2	HIST1H3F	6	26250542	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		26250542	144864525	22	520										
DST	667	broad.mit.edu	37	chr6	56357765	56357765	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	atttgaaataagactgtgtcCaagatgagacttggccgaga	11	6	0	5			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr6:56357765C>A	ENST00000370754.5	-	84	20423	c.20424G>T	c.(20422-20424)ttG>ttT	p.L6808F	DST_ENST00000370788.2_Missense_Mutation_p.L4433F|DST_ENST00000446842.2_Missense_Mutation_p.L6304F|DST_ENST00000361203.3_Missense_Mutation_p.L6519F|DST_ENST00000244364.6_Missense_Mutation_p.L4216F|DST_ENST00000370769.4_Missense_Mutation_p.L6630F|DST_ENST00000421834.2_Missense_Mutation_p.L4542F|DST_ENST00000312431.6_3'UTR			Q03001	DYST_HUMAN	dystonin	6628					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.L4216F(1)|p.L6630F(1)		NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGACTGTGTCCAAGATGAGAC	0.398													5	12					5.9392e-07	6.3396e-07	1	1	0	A	56357765	C	A	56357765	3	1	8	1	0	0	0	0	1	0	0	0	4809	593	21	5	2947	5	DST	6	56357765	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	30107223	56357765	114757302	23	521										
PHF3	23469	broad.mit.edu	37	chr6	64404543	64404543	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	aatggcagctagctcctcttCgtaagatgggacaaccagtt	10	10	1	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr6:64404543C>G	ENST00000262043.3	+	6	2909	c.2569C>G	c.(2569-2571)Cgt>Ggt	p.R857G	PHF3_ENST00000393387.1_Missense_Mutation_p.R857G			Q92576	PHF3_HUMAN	PHD finger protein 3	857					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGCTCCTCTTCGTAAGATGGG	0.383													4	153					0	0	1	0	0	G	64404543	C	G	64404543	3	3	8	1	0	0	0	0	1	0	0	0	11883	884	31	2	2587	2	PHF3	6	64404543	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	8046778	64404543	106710524	24	522										
THSD7A	221981	broad.mit.edu	37	chr7	11871427	11871427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gcgcctccgcctcgccctgcGccgcagccctgccggcgccc	12	24	0	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr7:11871427G>A	ENST00000423059.3	-	1	397	c.146C>T	c.(145-147)gCg>gTg	p.A49V		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	49						integral to membrane		p.A49V(1)		NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTCGCCCTGCGCCGCAGCCCT	0.706										HNSCC(18;0.044)			10	9					0	0	1	0	0	A	11871427	G	A	11871427	3	1	8	1	0	0	0	0	1	0	0	0	15938	1087	38	1	4935	1	THSD7A	7	11871427	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		11871427	147267236	25	523										
ZP3	7784	broad.mit.edu	37	chr7	76054351	76054351	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ctgagctgtgctacccccaaCccctctggctcttgcagggt	10	16	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr7:76054351C>A	ENST00000394857.3	+	1	128	c.70C>A	c.(70-72)Ccc>Acc	p.P24T	ZP3_ENST00000336517.4_Intron	NM_001110354.1	NP_001103824.1	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 (sperm receptor)	24					binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7						CTACCCCCAACCCCTCTGGCT	0.602													4	14					0.00024832	0.000256417	1	1	0	A	76054351	C	A	76054351	3	1	8	1	0	0	0	0	1	0	0	0	18258	507	18	5	72	5	ZP3	7	76054351	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	64182924	76054351	83084312	26	524										
MUC17	140453	broad.mit.edu	37	chr7	100683707	100683707	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tgccggtggccagttctgagGctagcaccctttcaagaact	11	12	2	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr7:100683707G>T	ENST00000306151.4	+	3	9074	c.9010G>T	c.(9010-9012)Gct>Tct	p.A3004S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3004	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCTGAGGCTAGCACCCT	0.517													173	478					1.34047e-99	1.55298e-99	1	1	0	T	100683707	G	T	100683707	3	4	8	1	0	0	0	0	1	0	0	0	10021	1203	42	5	9020	5	MUC17	7	100683707	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	24629356	100683707	58454956	27	525										
FSCN3	29999	broad.mit.edu	37	chr7	127235409	127235409	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	atgagacacaggccgtggtgCgactaaagagcgtgcagggc	16	9	0	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr7:127235409C>T	ENST00000265825.5	+	2	412	c.193C>T	c.(193-195)Cga>Tga	p.R65*	FSCN3_ENST00000420086.2_5'UTR|FSCN3_ENST00000478328.1_3'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	65						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						GGCCGTGGTGCGACTAAAGAG	0.562													27	75					0	0	1	0	0	T	127235409	C	T	127235409	4	4	8	1	0	0	0	0	0	1	0	0	6103	760	27	1	199	1	FSCN3	7	127235409	Nonsense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	26551702	127235409	31903254	28	526										
MGAM	8972	broad.mit.edu	37	chr7	141800609	141800609	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ctgctcactgcagccgccagAaattcatgggcttcaaaatt	8	12	3	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr7:141800609A>G	ENST00000475668.2	+	68	7936	c.7882A>G	c.(7882-7884)Aaa>Gaa	p.K2628E	MGAM_ENST00000549489.2_Missense_Mutation_p.K1732E			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1732					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAGCCGCCAGAAATTCATGGG	0.483													5	6					0	0	1	0	0	G	141800609	A	G	141800609	3	3	8	1	0	0	0	0	1	0	0	0	9590	247	9	4	5368	4	MGAM	7	141800609	Missense_Mutation	SNP	A	TCGA-N5-A4RO-01A-11D-A28R-08	14565200	141800609	17338054	29	527										
ZNF775	285971	broad.mit.edu	37	chr7	150094611	150094611	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	actgtggccgcggcttccgcCagaagcagcacctgctcaag	12	15	1	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr7:150094611C>T	ENST00000329630.5	+	3	1149	c.1042C>T	c.(1042-1044)Cag>Tag	p.Q348*		NM_173680.3	NP_775951.2	Q96BV0	ZN775_HUMAN	zinc finger protein 775	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(7)|skin(1)	11	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGCTTCCGCCAGAAGCAGCA	0.741													5	14					0	0	1	0	0	T	150094611	C	T	150094611	4	4	8	1	0	0	0	0	0	1	0	0	18196	595	21	3	1048	3	ZNF775	7	150094611	Nonsense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	8294002	150094611	9044052	30	528										
FAM135B	51059	broad.mit.edu	37	chr8	139164617	139164617	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	caactccagagccctgcttcGggcctctgaccaggcgacgg	12	16	1	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr8:139164617G>A	ENST00000395297.1	-	13	2271	c.2101C>T	c.(2101-2103)Cga>Tga	p.R701*		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	701										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCCTGCTTCGGGCCTCTGAC	0.557										HNSCC(54;0.14)			16	30					0	0	1	0	0	A	139164617	G	A	139164617	4	1	8	1	0	0	0	0	0	1	0	0	5480	1124	39	1	2151	1	FAM135B	8	139164617	Nonsense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		139164617	7199405	31	529										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18775890	18775890	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ccctgtatgctggcaacctgTgcaagtaagtatgtcagggc	12	10	1	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr9:18775890T>C	ENST00000380548.4	+	18	2886	c.2547T>C	c.(2545-2547)tgT>tgC	p.C849C		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	849	TSP type-1 7.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGGCAACCTGTGCAAGTAAGT	0.557													11	12					0	0	1	0	0	C	18775890	T	C	18775890	2	2	8	1	0	0	0	0	0	0	0	1	273	1702	59	4		4	ADAMTSL1	9	18775890	Silent	SNP	T	TCGA-N5-A4RO-01A-11D-A28R-08		18775890	122437541	32	530										
ZNF462	58499	broad.mit.edu	37	chr9	109765634	109765634	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gatcagctggaacagatgaaGgagaaaatggagagctccag	14	6	1	4			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr9:109765634G>A	ENST00000277225.5	+	11	7405	c.7116G>A	c.(7114-7116)aaG>aaA	p.K2372K	ZNF462_ENST00000441147.2_Silent_p.K1278K|RP11-508N12.2_ENST00000439901.1_RNA|ZNF462_ENST00000457913.1_Silent_p.K2432K|ZNF462_ENST00000542028.1_Silent_p.K329K			Q96JM2	ZN462_HUMAN	zinc finger protein 462	2372					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AACAGATGAAGGAGAAAATGG	0.473													5	101					0	0	1	0	0	A	109765634	G	A	109765634	2	1	8	1	0	0	0	0	0	0	0	1	17982	991	35	3		3	ZNF462	9	109765634	Silent	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	90989744	109765634	31447797	33	531										
SEC16A	9919	broad.mit.edu	37	chr9	139342755	139342756	+	Frame_Shift_Ins	INS	-	-	G													0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gacaccaggagaatggaggtINSgggagcagatccacagagac							TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr9:139342755_139342756insG	ENST00000398335.1	-	2	1676_1677	c.276_277insC	c.(274-279)cccctcfs	p.L93fs	SEC16A_ENST00000371706.3_Intron|SEC16A_ENST00000313084.5_Frame_Shift_Ins_p.L93fs|SEC16A_ENST00000290037.6_Intron|SEC16A_ENST00000431893.2_Intron|SEC16A_ENST00000313050.7_Intron			O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	667					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		agaatggaggtGGGAGCAGATC	0.559													2	4	---	---	---	---						G	139342756	-	G	139342755	7	5	8	1	0	1	1	0	0	0	0	0	14039	1711	59	0		0	SEC16A	9	139342755	Frame_Shift_Ins	INS	-	TCGA-N5-A4RO-01A-11D-A28R-08	29577121	139342755	1870676	34	532										
SUV39H2	79723	broad.mit.edu	37	chr10	14939228	14939228	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	atcagcttagtcaatgaagcTacctttggttgttcatgcac	8	9	3	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr10:14939228T>C	ENST00000313519.5	+	2	612	c.381T>C	c.(379-381)gcT>gcC	p.A127A	SUV39H2_ENST00000378325.3_Intron|SUV39H2_ENST00000354919.6_Silent_p.A187A	NM_001193425.1|NM_024670.3	NP_001180354.1|NP_078946.1	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2 (Drosophila)	187					cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)	19						TCAATGAAGCTACCTTTGGTT	0.363													34	46					0	0	1	0	0	C	14939228	T	C	14939228	2	2	8	1	0	0	0	0	0	0	0	1	15468	1509	53	4		4	SUV39H2	10	14939228	Silent	SNP	T	TCGA-N5-A4RO-01A-11D-A28R-08		14939228	120595519	35	533										
CUBN	8029	broad.mit.edu	37	chr10	16882377	16882377	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ttctgcgtgcagtcttgcgaGgtcagctgtaatgcccacac	11	12	3	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr10:16882377G>C	ENST00000377833.4	-	62	10049	c.9984C>G	c.(9982-9984)acC>acG	p.T3328T		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3328	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGTCTTGCGAGGTCAGCTGTA	0.463													14	20					0	0	1	0	0	C	16882377	G	C	16882377	2	2	8	1	0	0	0	0	0	0	0	1	4074	987	35	5		5	CUBN	10	16882377	Silent	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	1943149	16882377	118652370	36	534										
UBE2L6	9246	broad.mit.edu	37	chr11	57335061	57335061	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	atcctatacgcggttaccttCaccactcgcatgctcgccat	6	16	1	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr11:57335061C>A	ENST00000287156.4	-	1	219	c.24G>T	c.(22-24)gtG>gtT	p.V8V	UBE2L6_ENST00000340573.4_Intron	NM_004223.4	NP_004214.1	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6	8					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(3)|ovary(1)	5						CGGTTACCTTCACCACTCGCA	0.662													5	10					0.0215528	0.021782	1	1	0	A	57335061	C	A	57335061	2	1	8	1	0	0	0	0	0	0	0	1	16924	813	29	2		2	UBE2L6	11	57335061	Silent	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		57335061	77671455	37	535										
GRIA4	0	broad.mit.edu	37	chr11	105483157	105483157	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	aacagttttgctgtaacaaaCgcctgtaagtaaaacataag	7	7	0	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr11:105483157C>T	ENST00000393127.2	+	3	689	c.243C>T	c.(241-243)aaC>aaT	p.N81N	GRIA4_ENST00000527669.1_Silent_p.N81N|GRIA4_ENST00000525187.1_Silent_p.N81N|GRIA4_ENST00000282499.5_Silent_p.N81N|GRIA4_ENST00000393125.2_Silent_p.N81N|GRIA4_ENST00000428631.2_Silent_p.N81N|GRIA4_ENST00000530497.1_Silent_p.N81N	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	81					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTGTAACAAACGCCTGTAAGT	0.363													11	4					0	0	1	0	0	T	105483157	C	T	105483157	2	4	8	1	0	0	0	0	0	0	0	1	6810	535	19	1		1	GRIA4	11	105483157	Silent	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	48148096	105483157	29523359	38	536										
PLEKHG6	55200	broad.mit.edu	37	chr12	6421468	6421468	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gcattgagacttatgggggcCggcatcgagcctctgctcag	14	11	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr12:6421468C>T	ENST00000396988.3	+	2	306	c.76C>T	c.(76-78)Cgg>Tgg	p.R26W	PLEKHG6_ENST00000536531.1_Missense_Mutation_p.R26W|PLEKHG6_ENST00000538208.1_3'UTR|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.R26W	NM_001144856.1	NP_001138328.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	26					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						TTATGGGGGCCGGCATCGAGC	0.617													4	78					0	0	1	0	0	T	6421468	C	T	6421468	3	4	8	1	0	0	0	0	1	0	0	0	12121	643	23	1	78	1	PLEKHG6	12	6421468	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		6421468	127430427	39	537										
SDR9C7	121214	broad.mit.edu	37	chr12	57327822	57327822	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tggtgacatccagtagggtgGtctgcagccgataggaggta	16	7	1	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr12:57327822G>T	ENST00000293502.1	-	1	367	c.224C>A	c.(223-225)aCc>aAc	p.T75N		NM_148897.2	NP_683695.1	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C, member 7	75						cytoplasm	binding|oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)	7						CAGTAGGGTGGTCTGCAGCCG	0.577													56	35					7.89702e-26	8.93116e-26	1	1	0	T	57327822	G	T	57327822	3	4	8	1	0	0	0	0	1	0	0	0	14027	1261	44	5	733	5	SDR9C7	12	57327822	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	50906354	57327822	76524073	40	538										
ZIC2	7546	broad.mit.edu	37	chr13	100634935	100634935	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cccgcggaccgacccctactCggcggcgcaactccacaacc	9	21	0	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr13:100634935C>A	ENST00000376335.3	+	1	910	c.617C>A	c.(616-618)tCg>tAg	p.S206*		NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	206	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GACCCCTACTCGGCGGCGCAA	0.662													11	101					7.03913e-09	7.77578e-09	1	1	0	A	100634935	C	A	100634935	4	1	8	1	0	0	0	0	0	1	0	0	17736	893	31	2	619	2	ZIC2	13	100634935	Nonsense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		100634935	14534943	41	539										
OR4N5	390437	broad.mit.edu	37	chr14	20612258	20612258	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tcgttgtgatggcctttgacCgctacatcgccatctgccgg	11	13	1	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr14:20612258C>A	ENST00000333629.1	+	1	364	c.364C>A	c.(364-366)Cgc>Agc	p.R122S		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GGCCTTTGACCGCTACATCGC	0.483													51	78					8.72198e-27	9.98299e-27	1	1	0	A	20612258	C	A	20612258	3	1	8	1	0	0	0	0	1	0	0	0	11126	652	23	5	366	5	OR4N5	14	20612258	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		20612258	86737282	42	540										
CDC42BPB	9578	broad.mit.edu	37	chr14	103400064	103400064	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cggcttcaggtgtcacaggcCggctgctccaggccttcgag	14	14	2	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr14:103400064C>T	ENST00000361246.2	-	37	5409	c.5121G>A	c.(5119-5121)ccG>ccA	p.P1707P	RP11-365N19.2_ENST00000560931.1_RNA	NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1707					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGTCACAGGCCGGCTGCTCCA	0.667													3	4					0	0	1	0	0	T	103400064	C	T	103400064	2	4	8	1	0	0	0	0	0	0	0	1	3095	639	23	1		1	CDC42BPB	14	103400064	Silent	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	82787806	103400064	3949476	43	541										
GJD2	57369	broad.mit.edu	37	chr15	35045104	35045104	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ggattttgatgcagtgcgtaGacctgatgggtgtggagtca	16	5	1	3			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr15:35045104G>T	ENST00000290374.4	-	2	1017	c.541C>A	c.(541-543)Cta>Ata	p.L181I		NM_020660.2	NP_065711.1	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	181					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	19		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		GCAGTGCGTAGACCTGATGGG	0.493													4	110					0.150653	0.150653	1	1	0	T	35045104	G	T	35045104	3	4	8	1	0	0	0	0	1	0	0	0	6458	933	33	2	428	2	GJD2	15	35045104	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		35045104	67486288	44	542										
RASGRP1	10125	broad.mit.edu	37	chr15	38811527	38811527	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	taccttacaaaataacagatCttcaggcaaagtcctggtga	7	9	2	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr15:38811527C>T	ENST00000310803.5	-	4	549	c.372G>A	c.(370-372)aaG>aaA	p.K124K	RASGRP1_ENST00000450598.2_Silent_p.K124K|RASGRP1_ENST00000539159.1_Silent_p.K76K|RASGRP1_ENST00000558164.1_Silent_p.K124K|RASGRP1_ENST00000559830.1_Silent_p.K124K|RASGRP1_ENST00000561180.1_Silent_p.K175K	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	124	N-terminal Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		AATAACAGATCTTCAGGCAAA	0.413													27	32					0	0	1	0	0	T	38811527	C	T	38811527	2	4	8	1	0	0	0	0	0	0	0	1	13125	912	32	3		3	RASGRP1	15	38811527	Silent	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	3766423	38811527	63719865	45	543										
MAPK6	5597	broad.mit.edu	37	chr15	52356849	52356849	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ggtggggaggactgttttttCataaatcagttttgtgaggt	14	3	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr15:52356849C>G	ENST00000261845.5	+	6	2625	c.1818C>G	c.(1816-1818)ttC>ttG	p.F606L	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	606					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		ACTGTTTTTTCATAAATCAGT	0.403													25	31					0	0	1	0	0	G	52356849	C	G	52356849	3	3	8	1	0	0	0	0	1	0	0	0	9330	825	29	2	1836	2	MAPK6	15	52356849	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	13545322	52356849	50174543	46	544										
WDR72	256764	broad.mit.edu	37	chr15	54003562	54003562	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	agctgatagatgtaactgtgAccatcttctgtccagatgag	10	8	2	5			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr15:54003562A>G	ENST00000396328.1	-	8	1067	c.828T>C	c.(826-828)ggT>ggC	p.G276G	WDR72_ENST00000559418.1_Silent_p.G276G|WDR72_ENST00000557913.1_Silent_p.G275G|WDR72_ENST00000360509.5_Silent_p.G276G	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	276										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TGTAACTGTGACCATCTTCTG	0.438													5	38					0	0	1	0	0	G	54003562	A	G	54003562	2	3	8	1	0	0	0	0	0	0	0	1	17381	262	10	4		4	WDR72	15	54003562	Silent	SNP	A	TCGA-N5-A4RO-01A-11D-A28R-08	1646713	54003562	48527830	47	545										
ZNF19	7567	broad.mit.edu	37	chr16	71509657	71509657	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tttctccccagtgtggattcTctgatgtataacaaactcgg	8	10	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr16:71509657T>C	ENST00000288177.5	-	6	1048	c.793A>G	c.(793-795)Aga>Gga	p.R265G	ZNF19_ENST00000565100.2_Missense_Mutation_p.R195G|AC010547.9_ENST00000561908.1_Intron|ZNF19_ENST00000565637.1_Missense_Mutation_p.R223G|ZNF19_ENST00000567225.1_Intron|ZNF19_ENST00000564230.1_Missense_Mutation_p.R265G	NM_006961.3	NP_008892.2	P17023	ZNF19_HUMAN	zinc finger protein 19	265						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|prostate(1)|stomach(1)	22		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		GTGTGGATTCTCTGATGTATA	0.453													31	43					0	0	1	0	0	C	71509657	T	C	71509657	3	2	8	1	0	0	0	0	1	0	0	0	17812	1559	54	4	587	4	ZNF19	16	71509657	Missense_Mutation	SNP	T	TCGA-N5-A4RO-01A-11D-A28R-08		71509657	18845096	48	546										
SPG7	6687	broad.mit.edu	37	chr16	89620289	89620289	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	acctggcatcgggcccatctCcttccctgaggcgcaggagg	13	15	1	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr16:89620289C>T	ENST00000268704.2	+	15	2039	c.2024C>T	c.(2023-2025)tCc>tTc	p.S675F		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	675					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGGCCCATCTCCTTCCCTGAG	0.662													42	48					0	0	1	0	0	T	89620289	C	T	89620289	3	4	8	1	0	0	0	0	1	0	0	0	15099	855	30	3	2232	3	SPG7	16	89620289	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	18110632	89620289	734464	49	547										
C1QBP	708	broad.mit.edu	37	chr17	5338195	5338195	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	attatagtattagcttacctCctgttcttcaaccttctgcc	4	12	3	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr17:5338195C>T	ENST00000225698.4	-	3	556	c.475G>A	c.(475-477)Gag>Aag	p.E159K	C1QBP_ENST00000574444.1_Missense_Mutation_p.E55K	NM_001212.3	NP_001203.1	Q07021	C1QBP_HUMAN	complement component 1, q subcomponent binding protein	159					blood coagulation, intrinsic pathway|immune response|interspecies interaction between organisms	mitochondrial matrix|nucleus|plasma membrane				lung(2)|ovary(1)	3						TAGCTTACCTCCTGTTCTTCA	0.438													4	43					0	0	1	0	0	T	5338195	C	T	5338195	3	4	8	1	0	0	0	0	1	0	0	0	1969	864	30	3	389	3	C1QBP	17	5338195	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		5338195	75857015	50	548										
TP53	7157	broad.mit.edu	37	chr17	7579575	7579575	+	Frame_Shift_Del	DEL	G	G	-													0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	catcaaatcatccattgcttGggacggcaagggggactgta							TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr17:7579575delG	ENST00000420246.2	-	4	244	c.112delC	c.(112-114)aafs	p.Q38fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.Q38fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.Q38fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.Q38fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.Q38fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.Q38fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	38	Interaction with HRMT1L2.|Transcription activation (acidic).				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q38*(8)|p.0?(8)|p.P36fs*4(3)|p.?(1)|p.S33fs*23(1)|p.P13fs*18(1)|p.S37fs*79(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCATTGCTTGGGACGGCAAG	0.592		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			210	27	---	---	---	---						-	7579575	G	-	7579575	7	5	8	1	0	1	0	1	0	0	0	0	16441	1357	47	0	1190	0	TP53	17	7579575	Frame_Shift_Del	DEL	G	TCGA-N5-A4RO-01A-11D-A28R-08	2241380	7579575	73615635	51	549										
MYO15A	51168	broad.mit.edu	37	chr17	18060487	18060487	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	taggctacagtgctggctgcGtggttcgcaggaaggtggtg	18	7	0	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr17:18060487G>A	ENST00000205890.5	+	50	9069	c.8731G>A	c.(8731-8733)Gtg>Atg	p.V2911M	MYO15A_ENST00000418233.3_Missense_Mutation_p.V175M	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2911	SH3.|Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity	p.V2911M(1)		breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TGCTGGCTGCGTGGTTCGCAG	0.672													9	23					0	0	1	0	0	A	18060487	G	A	18060487	3	1	8	1	0	0	0	0	1	0	0	0	10110	1145	40	1	8921	1	MYO15A	17	18060487	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	10480912	18060487	63134723	52	550										
DHX58	79132	broad.mit.edu	37	chr17	40262802	40262802	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cgccagtgcctggggaggctGtgagacccagcacctggggt	17	12	0	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr17:40262802G>A	ENST00000251642.3	-	5	722	c.500C>T	c.(499-501)aCa>aTa	p.T167I		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	167	Helicase ATP-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGGGGAGGCTGTGAGACCCAG	0.627													4	78					0	0	1	0	0	A	40262802	G	A	40262802	3	1	8	1	0	0	0	0	1	0	0	0	4542	1377	48	3	1576	3	DHX58	17	40262802	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	22202315	40262802	40932408	53	551										
WNT9B	7484	broad.mit.edu	37	chr17	44952563	44952563	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tgggcgcatggagcgctgcaCctgtgatgactctccggggc	16	12	1	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr17:44952563C>G	ENST00000393461.2	+	3	484	c.431C>G	c.(430-432)aCc>aGc	p.T144S	WNT9B_ENST00000290015.2_Missense_Mutation_p.T144S			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	144					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GAGCGCTGCACCTGTGATGAC	0.647													118	9					0	0	1	0	0	G	44952563	C	G	44952563	3	3	8	1	0	0	0	0	1	0	0	0	17458	507	18	5	441	5	WNT9B	17	44952563	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08	4689761	44952563	36242647	54	552										
SPOP	8405	broad.mit.edu	37	chr17	47696730	47696730	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tttcttcatctaaccctttgGggtttactcgcaaacacctg	6	12	3	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr17:47696730G>C	ENST00000393331.3	-	6	688	c.218C>G	c.(217-219)cCc>cGc	p.P73R	SPOP_ENST00000504102.1_Missense_Mutation_p.P73R|SPOP_ENST00000503676.1_Missense_Mutation_p.P73R|SPOP_ENST00000393328.2_Missense_Mutation_p.P73R|SPOP_ENST00000347630.2_Missense_Mutation_p.P73R|SPOP_ENST00000513080.1_5'UTR	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	73	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TAACCCTTTGGGGTTTACTCG	0.393										Prostate(2;0.17)			25	2					0	0	1	0	0	C	47696730	G	C	47696730	3	2	8	1	0	0	0	0	1	0	0	0	15139	1232	43	5	934	5	SPOP	17	47696730	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	2744167	47696730	33498480	55	553										
TCEB3C	162699	broad.mit.edu	37	chr18	44554604	44554604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	agaatcttcccttgtagtctCgaattgccttggccatcagc	8	12	3	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr18:44554604C>T	ENST00000330682.2	-	1	1845	c.1610G>A	c.(1609-1611)cGa>cAa	p.R537Q	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	537					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						CTTGTAGTCTCGAATTGCCTT	0.602													8	394					0	0	1	0	0	T	44554604	C	T	44554604	3	4	8	1	0	0	0	0	1	0	0	0	15742	884	31	1	1677	1	TCEB3C	18	44554604	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		44554604	33522644	56	554										
ZNF536	9745	broad.mit.edu	37	chr19	30935256	30935256	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cctcgcccaagcctgccagcGtgcaggaggacgcggtggcc	15	16	0	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr19:30935256G>C	ENST00000355537.3	+	2	934	c.787G>C	c.(787-789)Gtg>Ctg	p.V263L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCCTGCCAGCGTGCAGGAGGA	0.711													6	124					0	0	1	0	0	C	30935256	G	C	30935256	3	2	8	1	0	0	0	0	1	0	0	0	18030	1145	40	5	789	5	ZNF536	19	30935256	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		30935256	28193727	57	555										
WDR88	126248	broad.mit.edu	37	chr19	33639792	33639792	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gcataatggacgccgagaacAtcaccaccgtttccgtcatc	8	14	2	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr19:33639792A>G	ENST00000361680.2	+	5	733	c.655A>G	c.(655-657)Atc>Gtc	p.I219V	WDR88_ENST00000355868.3_Missense_Mutation_p.I219V			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	219										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					CGCCGAGAACATCACCACCGT	0.502													28	120					0	0	1	0	0	G	33639792	A	G	33639792	3	3	8	1	0	0	0	0	1	0	0	0	17394	217	8	4	673	4	WDR88	19	33639792	Missense_Mutation	SNP	A	TCGA-N5-A4RO-01A-11D-A28R-08	2704536	33639792	25489191	58	556										
ZNF585A	199704	broad.mit.edu	37	chr19	37644265	37644265	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	agggtttctctctcatatggGttttctggtgtataataaat	9	5	3	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr19:37644265G>C	ENST00000356958.4	-	5	794	c.536C>G	c.(535-537)aCc>aGc	p.T179S	ZNF585A_ENST00000355533.2_Missense_Mutation_p.T124S|ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000392157.2_Missense_Mutation_p.T124S|ZNF585A_ENST00000292841.5_Missense_Mutation_p.T124S			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTCATATGGGTTTTCTGGTG	0.388													23	105					0	0	1	0	0	C	37644265	G	C	37644265	3	2	8	1	0	0	0	0	1	0	0	0	18073	1261	44	5	1777	5	ZNF585A	19	37644265	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	4004473	37644265	21484718	59	557										
KIR3DL1	3811	broad.mit.edu	37	chr19	55331226	55331226	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cccctggtgaaatcaggagaGagagtcatcctgcaatgttg	12	9	2	3			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr19:55331226G>C	ENST00000391728.4	+	4	447	c.414G>C	c.(412-414)gaG>gaC	p.E138D	KIR3DL1_ENST00000326542.7_Missense_Mutation_p.E138D|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.E43D|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.E138D|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.E138D|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.E138D	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		AATCAGGAGAGAGAGTCATCC	0.488													29	83					0	0	1	0	0	C	55331226	G	C	55331226	3	2	8	1	0	0	0	0	1	0	0	0	8362	933	33	2	428	2	KIR3DL1	19	55331226	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	17686961	55331226	3797757	60	558										
MATN4	8785	broad.mit.edu	37	chr20	43933030	43933030	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	ttcaatgccgcgggcgcgcgCctgtgccgccacctcggcca	13	18	1	0			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr20:43933030C>T	ENST00000537548.1	-	4	725	c.481G>A	c.(481-483)Gcg>Acg	p.A161T	MATN4_ENST00000372751.4_Intron|MATN4_ENST00000342716.4_Missense_Mutation_p.A161T|MATN4_ENST00000360607.5_Missense_Mutation_p.A161T|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000353917.5_Missense_Mutation_p.A161T|MATN4_ENST00000372756.1_Missense_Mutation_p.A161T|MATN4_ENST00000372754.1_Missense_Mutation_p.A161T			O95460	MATN4_HUMAN	matrilin 4	161	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				CGGGCGCGCGCCTGTGCCGCC	0.741													21	203					0	0	1	0	0	T	43933030	C	T	43933030	3	4	8	1	0	0	0	0	1	0	0	0	9385	739	26	3	1296	3	MATN4	20	43933030	Missense_Mutation	SNP	C	TCGA-N5-A4RO-01A-11D-A28R-08		43933030	19092490	61	559										
MC3R	4159	broad.mit.edu	37	chr20	54824467	54824467	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cggagagcaaaatggtcattGtgtgcctcatcaccatgttc	10	10	3	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr20:54824467G>A	ENST00000243911.2	+	1	680	c.568G>A	c.(568-570)Gtg>Atg	p.V190M		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	227					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			AATGGTCATTGTGTGCCTCAT	0.577													53	45					0	0	1	0	0	A	54824467	G	A	54824467	3	1	8	1	0	0	0	0	1	0	0	0	9414	1377	48	3	570	3	MC3R	20	54824467	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	10891437	54824467	8201053	62	560										
TIAM1	7074	broad.mit.edu	37	chr21	32624411	32624411	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	tgggtgagtagctggagttgGtggcattagatcgcctggac	17	6	0	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chr21:32624411G>C	ENST00000286827.3	-	6	1529	c.1058C>G	c.(1057-1059)aCc>aGc	p.T353S	TIAM1_ENST00000541036.1_Missense_Mutation_p.T353S|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	353					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GCTGGAGTTGGTGGCATTAGA	0.622													96	221					0	0	1	0	0	C	32624411	G	C	32624411	3	2	8	1	0	0	0	0	1	0	0	0	15949	1261	44	5	3813	5	TIAM1	21	32624411	Missense_Mutation	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08		32624411	15505484	63	561										
VSIG4	11326	broad.mit.edu	37	chrX	65242163	65242163	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	aatccagaggaactgtgtccAgcaggcgggcgtagttgcca	14	10	0	1			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chrX:65242163A>G	ENST00000374737.4	-	8	1250	c.1142T>C	c.(1141-1143)cTg>cCg	p.L381P	VSIG4_ENST00000455586.2_3'UTR|VSIG4_ENST00000412866.2_Missense_Mutation_p.L287P	NM_001257403.1|NM_007268.2	NP_001244332.1|NP_009199.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	381					complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AACTGTGTCCAGCAGGCGGGC	0.507													14	59					0	0	1	0	0	G	65242163	A	G	65242163	3	3	8	1	0	0	0	0	1	0	0	0	17284	188	7	4	61	4	VSIG4	23	65242163	Missense_Mutation	SNP	A	TCGA-N5-A4RO-01A-11D-A28R-08		65242163	90028397	64	562										
RGAG4	340526	broad.mit.edu	37	chrX	71350557	71350557	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	cggaagaattccgacaggccTttgaggaattggttttggag	14	6	0	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chrX:71350557T>A	ENST00000545866.1	-	1	1201	c.834A>T	c.(832-834)aaA>aaT	p.K278N	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.K278N			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	278										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					CCGACAGGCCTTTGAGGAATT	0.502													56	70					0	0	1	0	0	A	71350557	T	A	71350557	3	1	8	1	0	0	0	0	1	0	0	0	13326	1606	56	4	879	4	RGAG4	23	71350557	Missense_Mutation	SNP	T	TCGA-N5-A4RO-01A-11D-A28R-08	6108394	71350557	83920003	65	563										
CXorf57	55086	broad.mit.edu	37	chrX	105876451	105876451	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	6	1	1.23571428571429	3.08928571428571	0.308928571428571	0.118881118881119	0.651583710407241	0	gtggaactgttttcaacatcGcagccagaaatctttgaaaa	8	8	2	2			TCGA-N5-A4RO-01A-11D-A28R-08	TCGA-N5-A4RO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b84520b2-e8e8-42bc-ad82-94c0f8e04473	37c9ce50-b763-446c-94de-5c8528d68602	g.chrX:105876451G>A	ENST00000372548.4	+	6	1381	c.1272G>A	c.(1270-1272)tcG>tcA	p.S424S	CXorf57_ENST00000372544.2_Silent_p.S424S	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	424										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						TTTCAACATCGCAGCCAGAAA	0.318													19	5					0	0	1	0	0	A	105876451	G	A	105876451	2	1	8	1	0	0	0	0	0	0	0	1	4136	1074	38	1		1	CXorf57	23	105876451	Silent	SNP	G	TCGA-N5-A4RO-01A-11D-A28R-08	34525894	105876451	49394109	66	564										
ARHGEF10L	55160	broad.mit.edu	37	chr1	17944985	17944987	+	In_Frame_Del	DEL	CCT	CCT	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ccacgccgtcatccgctgtcCctcctcctcctcctcctctg							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr1:17944985_17944987delCCT	ENST00000375408.3	+	1	175_177	c.137_139delCCT	c.(136-141)ccc>c	p.PS46del	ARHGEF10L_ENST00000167825.4_In_Frame_Del_p.PS46del|ARHGEF10L_ENST00000361221.3_Intron|ARHGEF10L_ENST00000469726.1_Intron|ARHGEF10L_ENST00000452522.1_Intron|ARHGEF10L_ENST00000434513.1_Intron|ARHGEF10L_ENST00000375415.1_Intron|ARHGEF10L_ENST00000375420.3_Intron			Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	0					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		ATCCGCTGTCcctcctcctcctc	0.68													3	4	---	---	---	---						-	17944987	CCT	-	17944985	7	5	9	1	0	1	0	1	0	0	0	0	892	638	22	0		0	ARHGEF10L	1	17944985	In_Frame_Del	DEL	CCT	TCGA-N5-A4RS-01A-11D-A28R-08		17944985	231305636	1	565										
C1QB	713	broad.mit.edu	37	chr1	22986093	22986093	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ggtatccctgggacacctggCcccgatggccaacctgggac	13	15	0	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr1:22986093C>T	ENST00000509305.1	+	2	484	c.138C>T	c.(136-138)ggC>ggT	p.G46G	C1QB_ENST00000314933.6_Silent_p.G48G			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	48	Collagen-like 1.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGACACCTGGCCCCGATGGCC	0.602													9	14					0	0	1	0	0	T	22986093	C	T	22986093	2	4	9	1	0	0	0	0	0	0	0	1	1968	726	26	3		3	C1QB	1	22986093	Silent	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	5041108	22986093	226264528	2	566										
FUCA1	2517	broad.mit.edu	37	chr1	24175172	24175172	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tgttcttttcccattgcaccCgccatggtttggaggcatag	10	11	1	0	rs145603001	byFrequency	TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr1:24175172C>T	ENST00000374479.3	-	6	1134	c.1127G>A	c.(1126-1128)cGg>cAg	p.R376Q		NM_000147.4	NP_000138.2	P04066	FUCO_HUMAN	fucosidase, alpha-L- 1, tissue	376					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		CCATTGCACCCGCCATGGTTT	0.478													10	20					0	0	1	0	0	T	24175172	C	T	24175172	3	4	9	1	0	0	0	0	1	0	0	0	6128	652	23	1	285	1	FUCA1	1	24175172	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	1189079	24175172	225075449	3	567										
SETDB1	9869	broad.mit.edu	37	chr1	150933180	150933181	+	Frame_Shift_Del	DEL	GT	GT	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	cccctgttcctctgacagcaGtggtgtagacttgaaggacc							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr1:150933180_150933181delGT	ENST00000271640.5	+	16	2832_2833	c.2642_2643delGT	c.(2641-2643)afs	p.S881fs	SETDB1_ENST00000368969.4_Frame_Shift_Del_p.S881fs|SETDB1_ENST00000459773.1_3'UTR	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	881	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTGACAGCAGTGGTGTAGACT	0.475													28	47	---	---	---	---						-	150933181	GT	-	150933180	7	5	9	1	0	1	0	1	0	0	0	0	14191	1029	36	0	2700	0	SETDB1	1	150933180	Frame_Shift_Del	DEL	GT	TCGA-N5-A4RS-01A-11D-A28R-08	126758008	150933180	98317441	4	568										
CASQ1	844	broad.mit.edu	37	chr1	160168791	160168791	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ggctgtggcccaagataacaCtgaaaacccagatcttagca	9	11	1	3			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr1:160168791C>A	ENST00000368079.3	+	9	1189	c.914C>A	c.(913-915)aCt>aAt	p.T305N	CASQ1_ENST00000467691.1_Missense_Mutation_p.T32N|CASQ1_ENST00000368078.3_Missense_Mutation_p.T311N	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	311						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAAGATAACACTGAAAACCCA	0.502													19	31					5.03518e-11	6.20616e-11	1	1	0	A	160168791	C	A	160168791	3	1	9	1	0	0	0	0	1	0	0	0	2698	565	20	5	966	5	CASQ1	1	160168791	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	9235611	160168791	89081830	5	569										
ZNF638	27332	broad.mit.edu	37	chr2	71582903	71582903	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ttgagagctgtcgacagttaCgtcaacagtaagaatatatt	9	6	1	2			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr2:71582903C>A	ENST00000409544.1	+	3	2002	c.1372C>A	c.(1372-1374)Cgt>Agt	p.R458S	ZNF638_ENST00000377802.2_Missense_Mutation_p.R458S|ZNF638_ENST00000355812.3_Missense_Mutation_p.R458S|ZNF638_ENST00000264447.4_Missense_Mutation_p.R458S|ZNF638_ENST00000410075.1_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	458					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TCGACAGTTACGTCAACAGTA	0.284													3	7					0.115264	0.117481	1	1	0	A	71582903	C	A	71582903	3	1	9	1	0	0	0	0	1	0	0	0	18111	536	19	5	1378	5	ZNF638	2	71582903	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08		71582903	171616470	6	570										
SLC11A1	6556	broad.mit.edu	37	chr2	219249939	219249939	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	gactggctgcacgtctgggcGtggtgacaggcaaggacttg	17	9	1	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr2:219249939G>A	ENST00000233202.6	+	4	683	c.343G>A	c.(343-345)Gtg>Atg	p.V115M	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	115					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity	p.V115M(2)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGTCTGGGCGTGGTGACAGG	0.632													41	112					0	0	1	0	0	A	219249939	G	A	219249939	3	1	9	1	0	0	0	0	1	0	0	0	14434	1145	40	1	357	1	SLC11A1	2	219249939	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	147667036	219249939	23949434	7	571										
TTLL3	26140	broad.mit.edu	37	chr3	9874913	9874913	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	gcagtccctctgctgacccaGcgaggctctggggaaggcaa	14	13	2	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr3:9874913G>T	ENST00000547186.1	+	11	1896	c.1680G>T	c.(1678-1680)caG>caT	p.Q560H	TTLL3_ENST00000426895.4_Missense_Mutation_p.Q703H|TTLL3_ENST00000397241.1_Intron|TTLL3_ENST00000455274.1_Intron|TTLL3_ENST00000427853.3_Intron|TTLL3_ENST00000430793.1_Missense_Mutation_p.Q348H|ARPC4-TTLL3_ENST00000397256.1_Intron|TTLL3_ENST00000383827.1_Intron	NM_001025930.3	NP_001021100.3	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	560					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	Medulloblastoma(99;0.227)					TGCTGACCCAGCGAGGCTCTG	0.647													11	23					4.68919e-08	5.52282e-08	1	1	0	T	9874913	G	T	9874913	3	4	9	1	0	0	0	0	1	0	0	0	16789	962	34	5	1718	5	TTLL3	3	9874913	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08		9874913	188147517	8	572										
PIK3CA	5290	broad.mit.edu	37	chr3	178921552	178921552	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tctttgtgcaacctacgtgaAtgtaaatattcgagacattg	8	7	1	2			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr3:178921552A>C	ENST00000263967.3	+	5	1191	c.1034A>C	c.(1033-1035)aAt>aCt	p.N345T		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345I(4)|p.N345S(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACCTACGTGAATGTAAATATT	0.303		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			19	16					0	0	1	0	0	C	178921552	A	C	178921552	3	2	9	1	0	0	0	0	1	0	0	0	11960	101	4	4	1048	4	PIK3CA	3	178921552	Missense_Mutation	SNP	A	TCGA-N5-A4RS-01A-11D-A28R-08	169046639	178921552	19100878	9	573										
EPHA5	2044	broad.mit.edu	37	chr4	66218763	66218763	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ttattccccaatcctaccttCaaaaatgtatctaaagagcc	3	12	2	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr4:66218763C>A	ENST00000273854.3	-	13	2895	c.2295G>T	c.(2293-2295)ttG>ttT	p.L765F	EPHA5_ENST00000511294.1_Missense_Mutation_p.L766F|EPHA5_ENST00000354839.4_Missense_Mutation_p.L743F|EPHA5_ENST00000432638.2_Missense_Mutation_p.L602F	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	765	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ATCCTACCTTCAAAAATGTAT	0.358										TSP Lung(17;0.13)			9	13					0.00621372	0.00672096	1	1	0	A	66218763	C	A	66218763	3	1	9	1	0	0	0	0	1	0	0	0	5198	825	29	2	842	2	EPHA5	4	66218763	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08		66218763	124935513	10	574										
FBXW7	0	broad.mit.edu	37	chr4	153249384	153249384	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tttcatgaagatgcatacaaCgcacagtggaagtatgccca	9	9	1	2			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr4:153249384C>T	ENST00000281708.4	-	9	2623	c.1394G>A	c.(1393-1395)cGt>cAt	p.R465H	FBXW7_ENST00000296555.5_Missense_Mutation_p.R347H|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385H|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465H|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289H|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465H	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465H(69)|p.R385H(16)|p.R226H(16)|p.R465L(4)|p.R347H(4)|p.R465Y(2)|p.?(1)|p.R385L(1)|p.R226L(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATGCATACAACGCACAGTGGA	0.408			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								39	58					0	0	1	0	0	T	153249384	C	T	153249384	3	4	9	1	0	0	0	0	1	0	0	0	5801	536	19	1	745	1	FBXW7	4	153249384	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	87030621	153249384	37904892	11	575										
PIK3R1	5295	broad.mit.edu	37	chr5	67576381	67576382	+	Frame_Shift_Ins	INS	-	-	C													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	aaagctccgaagaatatattINScagctattgaagaagcttat							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr5:67576381_67576382insC	ENST00000521381.1	+	6	1276_1277	c.660_661insC	c.(658-663)atagctfs	p.A221fs	PIK3R1_ENST00000396611.1_Frame_Shift_Ins_p.A221fs|PIK3R1_ENST00000521657.1_Frame_Shift_Ins_p.A221fs|PIK3R1_ENST00000274335.5_Frame_Shift_Ins_p.A221fs	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	221	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAGAATATATTCAGCTATTGAA	0.351			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			104	90	---	---	---	---						C	67576382	-	C	67576381	7	5	9	1	0	1	1	0	0	0	0	0	11965	1771	62	0	678	0	PIK3R1	5	67576381	Frame_Shift_Ins	INS	-	TCGA-N5-A4RS-01A-11D-A28R-08		67576381	113338879	12	576										
ANKRD6	22881	broad.mit.edu	37	chr6	90276788	90276788	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	aatgtggttcagctcatcaaCaagggcgccagggtagcggt	14	9	3	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr6:90276788C>G	ENST00000369408.5	+	2	442	c.93C>G	c.(91-93)aaC>aaG	p.N31K	ANKRD6_ENST00000339746.4_Missense_Mutation_p.N31K|ANKRD6_ENST00000522441.1_Missense_Mutation_p.N31K|ANKRD6_ENST00000485637.1_Missense_Mutation_p.N31K|ANKRD6_ENST00000447838.2_Missense_Mutation_p.N31K|ANKRD6_ENST00000520793.1_Missense_Mutation_p.N31K|ANKRD6_ENST00000520886.2_Intron	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	31							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		AGCTCATCAACAAGGGCGCCA	0.502													6	9					0	0	1	0	0	G	90276788	C	G	90276788	3	3	9	1	0	0	0	0	1	0	0	0	679	477	17	5	95	5	ANKRD6	6	90276788	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08		90276788	80838279	13	577										
THBS2	7058	broad.mit.edu	37	chr6	169626326	169626326	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tcacagtgatcccccacaccGtcaccatccgtgtccctctg	6	19	3	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr6:169626326G>A	ENST00000366787.3	-	17	2736	c.2487C>T	c.(2485-2487)gaC>gaT	p.D829D	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	829					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCCCCACACCGTCACCATCCG	0.542													46	49					0	0	1	0	0	A	169626326	G	A	169626326	2	1	9	1	0	0	0	0	0	0	0	1	15913	1136	40	1		1	THBS2	6	169626326	Silent	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	79349538	169626326	1488741	14	578										
PTP4A3	11156	broad.mit.edu	37	chr8	142441037	142441037	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ctcttcccaggaagcgccgcGgagccatcaacagcaagcag	11	15	2	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr8:142441037G>A	ENST00000520105.1	+	5	1283	c.340G>A	c.(340-342)Gga>Aga	p.G114R	PTP4A3_ENST00000524028.1_Missense_Mutation_p.G53R|PTP4A3_ENST00000349124.1_Missense_Mutation_p.G114R|PTP4A3_ENST00000521578.1_Missense_Mutation_p.G139R|PTP4A3_ENST00000329397.1_Missense_Mutation_p.G139R			O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	139	Tyrosine-protein phosphatase.					early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(2)|large_intestine(1)|lung(3)	6	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			GAAGCGCCGCGGAGCCATCAA	0.597													15	17					0	0	1	0	0	A	142441037	G	A	142441037	3	1	9	1	0	0	0	0	1	0	0	0	12821	1117	39	1	433	1	PTP4A3	8	142441037	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08		142441037	3922985	15	579										
TTF1	7270	broad.mit.edu	37	chr9	135251330	135251330	+	Frame_Shift_Del	DEL	A	A	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tccaccggccttggcctcccAaagtactggaattacaggcg							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr9:135251330delA	ENST00000334270.2	-	11	2729	c.2690delT	c.(2689-2691)tgfs	p.L897fs	TTF1_ENST00000461970.1_5'UTR	NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	897					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ttggcctcccaaagtactgga	0.483													4	9	---	---	---	---						-	135251330	A	-	135251330	7	5	9	1	0	1	0	1	0	0	0	0	16779	131	5	0	31	0	TTF1	9	135251330	Frame_Shift_Del	DEL	A	TCGA-N5-A4RS-01A-11D-A28R-08		135251330	5962101	16	580										
AKR1C3	8644	broad.mit.edu	37	chr10	5144364	5144364	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tcgaaagatattgttctggtTgcctatagtgctctgggatc	11	7	2	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr10:5144364T>C	ENST00000380554.3	+	6	1294	c.642T>C	c.(640-642)gtT>gtC	p.V214V	AKR1C3_ENST00000605149.1_Silent_p.V191V|AKR1C3_ENST00000439082.2_Silent_p.V95V	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	214					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	TTGTTCTGGTTGCCTATAGTG	0.383													20	30					0	0	1	0	0	C	5144364	T	C	5144364	2	2	9	1	0	0	0	0	0	0	0	1	468	1799	63	4		4	AKR1C3	10	5144364	Silent	SNP	T	TCGA-N5-A4RS-01A-11D-A28R-08		5144364	130390383	17	581										
TAF5	6877	broad.mit.edu	37	chr10	105139460	105139460	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	gaaggaaaacctaaaaagaaGaagcctaaaaaagatagtat	8	4	0	3			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr10:105139460G>T	ENST00000369839.3	+	4	1232	c.1209G>T	c.(1207-1209)aaG>aaT	p.K403N	TAF5_ENST00000351396.4_Missense_Mutation_p.K403N	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	403	Poly-Lys.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CTAAAAAGAAGAAGCCTAAAA	0.373													14	20					3.27435e-08	3.94411e-08	1	1	0	T	105139460	G	T	105139460	3	4	9	1	0	0	0	0	1	0	0	0	15584	933	33	2	1223	2	TAF5	10	105139460	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	99995096	105139460	30395287	18	582										
PHC1	1911	broad.mit.edu	37	chr12	9075367	9075367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ctgctcagtctcctggagttCatgcagatgcagatcaggtt	11	10	4	2			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr12:9075367C>G	ENST00000433083.2	+	5	605	c.460C>G	c.(460-462)Cat>Gat	p.H154D	PHC1_ENST00000543824.1_Missense_Mutation_p.H199D|PHC1_ENST00000433847.2_3'UTR|PHC1_ENST00000536844.1_5'UTR|PHC1_ENST00000544916.1_Missense_Mutation_p.H199D			P78364	PHC1_HUMAN	polyhomeotic homolog 1 (Drosophila)	199					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding	p.H199Y(2)		breast(2)|cervix(1)|endometrium(5)|large_intestine(8)|liver(2)|lung(3)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	27						TCCTGGAGTTCATGCAGATGC	0.592													9	9					0	0	1	0	0	G	9075367	C	G	9075367	3	3	9	1	0	0	0	0	1	0	0	0	11863	826	29	2	613	2	PHC1	12	9075367	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08		9075367	124776528	19	583										
KRAS	3845	broad.mit.edu	37	chr12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ggcactcttgcctacgccacCagctccaactaccacaagtt	6	17	1	0	rs121913530		TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			10	3					2.17888e-05	2.51045e-05	1	1	0	A	25398285	C	A	25398285	3	1	9	1	0	0	0	0	1	0	0	0	8480	594	21	5	672	5	KRAS	12	25398285	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	16322918	25398285	108453610	20	584										
NPC2	10577	broad.mit.edu	37	chr14	74951225	74951225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	accatcaggctcaggaatggGaaagggaactgggacgccca	14	10	2	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr14:74951225G>A	ENST00000541064.1	-	3	262	c.256C>T	c.(256-258)Ccc>Tcc	p.P86S	NPC2_ENST00000238633.2_Missense_Mutation_p.P86S|NPC2_ENST00000434013.2_Missense_Mutation_p.P86S|NPC2_ENST00000557510.1_Missense_Mutation_p.P86S|NPC2_ENST00000555619.1_Missense_Mutation_p.P86S			P61916	NPC2_HUMAN	Niemann-Pick disease, type C2	86			P -> L (in dbSNP:rs4688).		cholesterol efflux|cholesterol homeostasis|glycolipid transport|intracellular cholesterol transport|phospholipid transport|regulation of isoprenoid metabolic process|response to virus	extracellular region|lysosome	cholesterol binding|enzyme binding			breast(1)|endometrium(2)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.00149)		TCAGGAATGGGAAAGGGAACT	0.433													37	52					0	0	1	0	0	A	74951225	G	A	74951225	3	1	9	1	0	0	0	0	1	0	0	0	10618	1174	41	3	211	3	NPC2	14	74951225	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08		74951225	32398315	21	585										
BMF	90427	broad.mit.edu	37	chr15	40398008	40398008	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	gcactcaccataaaagagtcGctggggttcctcagtcaccc	9	14	3	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr15:40398008G>A	ENST00000354670.4	-	3	514	c.280C>T	c.(280-282)Cga>Tga	p.R94*	BMF_ENST00000431415.3_Nonsense_Mutation_p.R94*|BMF_ENST00000220446.4_Nonsense_Mutation_p.R94*|BMF_ENST00000558774.1_Nonsense_Mutation_p.R94*|BMF_ENST00000561360.1_Nonsense_Mutation_p.R94*|BMF_ENST00000561282.1_Nonsense_Mutation_p.R94*|BMF_ENST00000559701.1_Nonsense_Mutation_p.R94*|BMF_ENST00000397573.1_Nonsense_Mutation_p.R94*	NM_001003940.1	NP_001003940.1	Q96LC9	BMF_HUMAN	Bcl2 modifying factor	94					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		TAAAAGAGTCGCTGGGGTTCC	0.577													50	71					0	0	1	0	0	A	40398008	G	A	40398008	4	1	9	1	0	0	0	0	0	1	0	0	1453	1095	38	1	286	1	BMF	15	40398008	Nonsense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08		40398008	62133384	22	586										
HCN4	10021	broad.mit.edu	37	chr15	73616239	73616239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tctcctggtagttgaagacgCcggagttgaggtcgtgctgg	16	8	1	3			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr15:73616239C>T	ENST00000261917.3	-	8	3188	c.2195G>A	c.(2194-2196)gGc>gAc	p.G732D		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	732					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GTTGAAGACGCCGGAGTTGAG	0.597													22	30					0	0	1	0	0	T	73616239	C	T	73616239	3	4	9	1	0	0	0	0	1	0	0	0	7039	739	26	3	1420	3	HCN4	15	73616239	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	33218231	73616239	28915153	23	587										
MRPS11	64963	broad.mit.edu	37	chr15	89021195	89021195	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	aacggctgccgccccaggaaGgctcggaagctgtgatggga	16	11	0	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr15:89021195G>A	ENST00000325844.4	+	6	835	c.570G>A	c.(568-570)aaG>aaA	p.K190K	MRPS11_ENST00000353598.6_Silent_p.K157K	NM_022839.3	NP_073750.2	P82912	RT11_HUMAN	mitochondrial ribosomal protein S11	190					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			large_intestine(3)	3	Lung NSC(78;0.203)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GCCCCAGGAAGGCTCGGAAGC	0.587													38	31					0	0	1	0	0	A	89021195	G	A	89021195	2	1	9	1	0	0	0	0	0	0	0	1	9870	991	35	3		3	MRPS11	15	89021195	Silent	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	15404956	89021195	13510197	24	588										
TP53	7157	broad.mit.edu	37	chr17	7578556	7578556	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tgttgagggcaggggagtacTgtaggaagaggaaggagaca	19	3	0	3			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr17:7578556T>G	ENST00000420246.2	-	5	508		c.e5-2		TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(34)|p.0?(8)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGAGTACTGTAGGAAGAG	0.552		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	3					0	0	1	0	0	G	7578556	T	G	7578556	5	3	9	1	0	0	0	0	0	0	1	0	16441	1594	55	4	924	4	TP53	17	7578556	Splice_Site	SNP	T	TCGA-N5-A4RS-01A-11D-A28R-08		7578556	73616654	25	589										
ZNF830	91603	broad.mit.edu	37	chr17	33289163	33289164	+	Frame_Shift_Del	DEL	CA	CA	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	cgcacagggcaaggagcactCagtttcctcttcacgggagg							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr17:33289163_33289164delCA	ENST00000361952.3	+	1	615_616	c.578_579delCA	c.(577-579)tfs	p.S193fs		NM_052857.3	NP_443089.3	Q96NB3	ZN830_HUMAN	zinc finger protein 830	193					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|liver(2)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(249;0.17)				AAGGAGCACTCAGTTTCCTCTT	0.525													22	23	---	---	---	---						-	33289164	CA	-	33289163	7	5	9	1	0	1	0	1	0	0	0	0	18230	838	29	0	580	0	ZNF830	17	33289163	Frame_Shift_Del	DEL	CA	TCGA-N5-A4RS-01A-11D-A28R-08	25710607	33289163	47906047	26	590										
SERPINB2	5055	broad.mit.edu	37	chr18	61570285	61570285	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	gaagcatgggcatggaggacGccttcaacaagggacgggcc	16	10	1	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr18:61570285G>A	ENST00000457692.1	+	9	1327	c.994G>A	c.(994-996)Gcc>Acc	p.A332T	SERPINB2_ENST00000299502.4_Missense_Mutation_p.A332T	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	332					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CATGGAGGACGCCTTCAACAA	0.463													22	33					0	0	1	0	0	A	61570285	G	A	61570285	3	1	9	1	0	0	0	0	1	0	0	0	14154	1087	38	1	1020	1	SERPINB2	18	61570285	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08		61570285	16506963	27	591										
ATP4A	495	broad.mit.edu	37	chr19	36046394	36046394	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tctgctgggggctggtgcgcGcaaacaccatctcggggtgg	17	11	2	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr19:36046394G>A	ENST00000262623.3	-	14	2133	c.2105C>T	c.(2104-2106)gCg>gTg	p.A702V		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	702					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GCTGGTGCGCGCAAACACCAT	0.662													5	163					0	0	1	0	0	A	36046394	G	A	36046394	3	1	9	1	0	0	0	0	1	0	0	0	1144	1087	38	1	1038	1	ATP4A	19	36046394	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08		36046394	23082589	28	592										
JAG1	182	broad.mit.edu	37	chr20	10653632	10653635	+	Frame_Shift_Del	DEL	AACT	AACT	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tggacaggatctccaactcgAactgacccgaggccccacac							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr20:10653632_10653635delAACT	ENST00000254958.5	-	2	616_619	c.101_104delAGTT	c.(100-105)ccfs	p.QF34fs	RP11-103J8.1_ENST00000605292.1_RNA	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	34					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CTCCAACTCGAACTGACCCGAGGC	0.642									Alagille Syndrome				22	62	---	---	---	---						-	10653635	AACT	-	10653632	7	5	9	1	0	1	0	1	0	0	0	0	7977	246	9	0	3652	0	JAG1	20	10653632	Frame_Shift_Del	DEL	AACT	TCGA-N5-A4RS-01A-11D-A28R-08		10653632	52371888	29	593										
DLGAP4	22839	broad.mit.edu	37	chr20	35061024	35061024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ccactctgaccctcagccacGcccacgaggtctgccagaag	9	18	3	2			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr20:35061024G>A	ENST00000373913.3	+	3	1384	c.904G>A	c.(904-906)Gcc>Acc	p.A302T	DLGAP4_ENST00000339266.5_Missense_Mutation_p.A302T|DLGAP4_ENST00000373907.2_Missense_Mutation_p.A302T|DLGAP4_ENST00000401952.2_Missense_Mutation_p.A302T			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	302					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCTCAGCCACGCCCACGAGGT	0.637													4	17					0	0	1	0	0	A	35061024	G	A	35061024	3	1	9	1	0	0	0	0	1	0	0	0	4590	1087	38	1	906	1	DLGAP4	20	35061024	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	24407392	35061024	27964496	30	594										
BAGE2	85319	broad.mit.edu	37	chr21	11039939	11039941	+	RNA	DEL	GTT	GTT	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	aatattctttggatataatcGttgttcttcatcattgtctg					rs146620410		TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr21:11039939_11039941delGTT	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGATATAATCGTTGTTCTTCATC	0.32													4	4	---	---	---	---						-	11039941	GTT	-	11039939	6	5	9	0	1	1	0	1	0	0	0	0	1290	1160	40	0		0	BAGE2	21	11039939	RNA	DEL	GTT	TCGA-N5-A4RS-01A-11D-A28R-08		11039939	37089956	31	595										
BAGE2	85319	broad.mit.edu	37	chr21	11056529	11056530	+	RNA	DEL	GA	GA	-													0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tattgcttatgtatttttatGagtctccataagtctatttt							TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr21:11056529_11056530delGA	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gtatttttatgagtctccataa	0.272													2	4	---	---	---	---						-	11056530	GA	-	11056529	6	5	9	0	1	1	0	1	0	0	0	0	1290	1305	45	0		0	BAGE2	21	11056529	RNA	DEL	GA	TCGA-N5-A4RS-01A-11D-A28R-08	16590	11056529	37073366	32	596										
POTED	317754	broad.mit.edu	37	chr21	14982927	14982927	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tggggagactacgaccacagCgccttcatggagccgaggta	14	11	1	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr21:14982927C>T	ENST00000299443.5	+	1	430	c.378C>T	c.(376-378)agC>agT	p.S126S		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	126						plasma membrane				central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						ACGACCACAGCGCCTTCATGG	0.597													50	89					0	0	1	0	0	T	14982927	C	T	14982927	2	4	9	1	0	0	0	0	0	0	0	1	12309	767	27	1		1	POTED	21	14982927	Silent	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	3926398	14982927	33146968	33	597										
POTED	317754	broad.mit.edu	37	chr21	15011886	15011886	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ttctgaagaacagaacactgGaatatcacaagatgagattc	8	7	2	5			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr21:15011886G>A	ENST00000299443.5	+	10	1512	c.1460G>A	c.(1459-1461)gGa>gAa	p.G487E		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	487						plasma membrane		p.G487E(1)		central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						CAGAACACTGGAATATCACAA	0.323													3	30					0	0	1	0	0	A	15011886	G	A	15011886	3	1	9	1	0	0	0	0	1	0	0	0	12309	1174	41	3	1498	3	POTED	21	15011886	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	28959	15011886	33118009	34	598										
SREBF2	6721	broad.mit.edu	37	chr22	42299024	42299024	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	ctgtcgctacggacagcgctCtggcaaaaacaggccagtgc	12	13	1	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chr22:42299024C>T	ENST00000361204.4	+	17	3124	c.2958C>T	c.(2956-2958)ctC>ctT	p.L986L	SREBF2_ENST00000491541.1_3'UTR	NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	986					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GGACAGCGCTCTGGCAAAAAC	0.657													4	0					0	0	1	0	0	T	42299024	C	T	42299024	2	4	9	1	0	0	0	0	0	0	0	1	15197	900	32	3		3	SREBF2	22	42299024	Silent	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08		42299024	9005542	35	599										
AMOT	154796	broad.mit.edu	37	chrX	112022454	112022454	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	gccggagctggaactggagcCggagcagctggagcaacctg	17	11	0	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chrX:112022454C>T	ENST00000371959.3	-	10	2927	c.2928G>A	c.(2926-2928)ccG>ccA	p.P976P	AMOT_ENST00000304758.1_Silent_p.P567P|AMOT_ENST00000524145.1_Silent_p.P976P|AMOT_ENST00000371962.1_Silent_p.P744P	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	976					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GAACTGGAGCCGGAGCAGCTG	0.627													9	8					0	0	1	0	0	T	112022454	C	T	112022454	2	4	9	1	0	0	0	0	0	0	0	1	578	639	23	1		1	AMOT	23	112022454	Silent	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08		112022454	43248106	36	600										
ZIC3	7547	broad.mit.edu	37	chrX	136649210	136649210	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	tcaacgcgcgagtttctgttCcgccagcgcagctccgggct	12	15	2	0			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chrX:136649210C>A	ENST00000287538.5	+	1	910	c.360C>A	c.(358-360)ttC>ttA	p.F120L	ZIC3_ENST00000370606.3_Missense_Mutation_p.F120L	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	120					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					AGTTTCTGTTCCGCCAGCGCA	0.677													4	2					0.00909568	0.00964142	1	1	0	A	136649210	C	A	136649210	3	1	9	1	0	0	0	0	1	0	0	0	17737	854	30	2	362	2	ZIC3	23	136649210	Missense_Mutation	SNP	C	TCGA-N5-A4RS-01A-11D-A28R-08	24626756	136649210	18621350	37	601										
L1CAM	3897	broad.mit.edu	37	chrX	153131272	153131272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0526315789473684	2	1	0.838271604938272	4.19135802469136	0.465706447187929	1	1	0	cagctcagggattgcctgggGgtctggaaaccaccagtgac	14	11	2	1			TCGA-N5-A4RS-01A-11D-A28R-08	TCGA-N5-A4RS-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5af5265b-b489-4307-b4b7-9ea5d8f1b461	a5091274-8175-4e71-831a-a07f6aef2908	g.chrX:153131272G>A	ENST00000370060.1	-	20	2623	c.2434C>T	c.(2434-2436)Ccc>Tcc	p.P812S	L1CAM_ENST00000370057.3_Missense_Mutation_p.P812S|L1CAM_ENST00000361699.4_Missense_Mutation_p.P812S|L1CAM_ENST00000543994.1_Missense_Mutation_p.P814S|L1CAM_ENST00000538883.1_Missense_Mutation_p.P814S|L1CAM_ENST00000370055.1_Missense_Mutation_p.P807S|L1CAM_ENST00000361981.3_Missense_Mutation_p.P807S	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	812	Fibronectin type-III 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATTGCCTGGGGGTCTGGAAAC	0.592													50	55					0	0	1	0	0	A	153131272	G	A	153131272	3	1	9	1	0	0	0	0	1	0	0	0	8626	1232	43	3	1379	3	L1CAM	23	153131272	Missense_Mutation	SNP	G	TCGA-N5-A4RS-01A-11D-A28R-08	16482062	153131272	2139288	38	602										
ALDH4A1	8659	broad.mit.edu	37	chr1	19200974	19200974	+	Missense_Mutation	SNP	C	C	A													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	caccagaggctcgggcccccCcaaagggctgctggcccact							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:19200974C>A	ENST00000375341.3	-	14	1819	c.1562G>T	c.(1561-1563)gGg>gTg	p.G521V	RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000290597.5_Missense_Mutation_p.G521V|ALDH4A1_ENST00000538839.1_Missense_Mutation_p.G470V|ALDH4A1_ENST00000538309.1_Missense_Mutation_p.G461V	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	521					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TCGGGCCCCCCCAAAGGGCTG	0.607													7	91					2.7689e-08	3.19333e-08	1	1	0	A	19200974	C	A	19200974	3	1	10	1	0	0	0	0	1	0	0	0	498	623	22	5	137	5	ALDH4A1	1	19200974	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		19200974	230049647	1	603	3	2								
ALDH4A1	8659	broad.mit.edu	37	chr1	19200975	19200975	+	Missense_Mutation	SNP	C	C	A													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	accagaggctcgggccccccCaaagggctgctggcccacta							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:19200975C>A	ENST00000375341.3	-	14	1818	c.1561G>T	c.(1561-1563)Ggg>Tgg	p.G521W	RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000290597.5_Missense_Mutation_p.G521W|ALDH4A1_ENST00000538839.1_Missense_Mutation_p.G470W|ALDH4A1_ENST00000538309.1_Missense_Mutation_p.G461W	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	521					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	CGGGCCCCCCCAAAGGGCTGC	0.612													8	92					1.06961e-07	1.22463e-07	1	1	0	A	19200975	C	A	19200975	3	1	10	1	0	0	0	0	1	0	0	0	498	594	21	5	138	5	ALDH4A1	1	19200975	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	1	19200975	230049646	2	604	3	2								
LYPLA2	11313	broad.mit.edu	37	chr1	24121215	24121218	+	Frame_Shift_Del	DEL	CTGT	CTGT	-													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tcttgagaagctgctgcctcCtgtctaactagtcgctggcc							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:24121215_24121218delCTGT	ENST00000374514.3	+	10	996_999	c.689_692delCTGT	c.(688-693)ccfs	p.PV230fs	LYPLA2_ENST00000374505.2_3'UTR|LYPLA2_ENST00000374503.3_3'UTR|LYPLA2_ENST00000495365.1_3'UTR|LYPLA2_ENST00000374501.1_Frame_Shift_Del_p.PV163fs|LYPLA2_ENST00000400061.1_3'UTR|LYPLA2_ENST00000374502.3_3'UTR	NM_007260.2	NP_009191.1	O95372	LYPA2_HUMAN	lysophospholipase II	230					fatty acid metabolic process	cytoplasm	hydrolase activity			endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		CTGCTGCCTCCTGTCTAACTAGTC	0.593													8	24	---	---	---	---						-	24121218	CTGT	-	24121215	7	5	10	1	0	1	0	1	0	0	0	0	9162	681	24	0	723	0	LYPLA2	1	24121215	Frame_Shift_Del	DEL	CTGT	TCGA-N5-A4RT-01A-11D-A28R-08	4920240	24121215	225129406	3	605										
ZNF683	257101	broad.mit.edu	37	chr1	26691433	26691433	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ataggtgaacaggtggggtgGaggcaggagaagtgggtatc	20	3	0	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:26691433G>T	ENST00000436292.1	-	4	724	c.604C>A	c.(604-606)Cca>Aca	p.P202T	ZNF683_ENST00000403843.1_Missense_Mutation_p.P202T|ZNF683_ENST00000374204.1_Missense_Mutation_p.P202T|ZNF683_ENST00000349618.3_Missense_Mutation_p.P202T			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		AGGTGGGGTGGAGGCAGGAGA	0.602													14	37					1.49906e-05	1.6798e-05	1	1	0	T	26691433	G	T	26691433	3	4	10	1	0	0	0	0	1	0	0	0	18145	1174	41	2	922	2	ZNF683	1	26691433	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	2570218	26691433	222559188	4	606										
SFPQ	6421	broad.mit.edu	37	chr1	35652661	35652661	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tggaacgccaggattagcttCataacctatgccaccaccac	7	14	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:35652661C>T	ENST00000357214.5	-	9	2025	c.1927G>A	c.(1927-1929)Gaa>Aaa	p.E643K		NM_005066.2	NP_005057.1	P23246	SFPQ_HUMAN	splicing factor proline/glutamine-rich	643					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|RNA binding		SFPQ/TFE3(6)	NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGATTAGCTTCATAACCTATG	0.463			T	TFE3	papillary renal cell								17	86					0	0	1	0	0	T	35652661	C	T	35652661	3	4	10	1	0	0	0	0	1	0	0	0	14213	835	29	3	204	3	SFPQ	1	35652661	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	8961228	35652661	213597960	5	607										
SMCP	4184	broad.mit.edu	37	chr1	152857173	152857173	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggagtctgagcccaactcacCgcaaactcaggacaagggct	11	13	3	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:152857173C>G	ENST00000368765.3	+	2	425	c.275C>G	c.(274-276)cCg>cGg	p.P92R		NM_030663.2	NP_109588.2	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich protein	92					penetration of zona pellucida|sperm motility	mitochondrial membrane		p.P92L(1)		breast(1)|cervix(1)|endometrium(1)|lung(4)|urinary_tract(1)	8	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCAACTCACCGCAAACTCAG	0.532													7	195					0	0	1	0	0	G	152857173	C	G	152857173	3	3	10	1	0	0	0	0	1	0	0	0	14842	652	23	5	277	5	SMCP	1	152857173	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	117204512	152857173	96393448	6	608										
PGLYRP4	57115	broad.mit.edu	37	chr1	153312868	153312868	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cccactcacttataaccaatGtcgcatgacttgagcctgtc	6	14	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:153312868G>T	ENST00000368739.3	-	7	1159	c.801C>A	c.(799-801)gaC>gaA	p.D267E	PGLYRP4_ENST00000359650.5_Missense_Mutation_p.D271E			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	271					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TATAACCAATGTCGCATGACT	0.502													36	63					1.836e-18	2.30229e-18	1	1	0	T	153312868	G	T	153312868	3	4	10	1	0	0	0	0	1	0	0	0	11843	1368	48	5	320	5	PGLYRP4	1	153312868	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	455695	153312868	95937753	7	609										
ZBTB7B	51043	broad.mit.edu	37	chr1	154988736	154988736	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	acatgcggaagcacacgggaGagcgcccctactcatgcccg	12	15	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:154988736G>C	ENST00000368426.3	+	4	1332	c.1195G>C	c.(1195-1197)Gag>Cag	p.E399Q	ZBTB7B_ENST00000292176.2_Missense_Mutation_p.E399Q|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.E433Q|ZBTB7B_ENST00000535420.1_Missense_Mutation_p.E399Q	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	399					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACACGGGAGAGCGCCCCTA	0.632													49	76					0	0	1	0	0	C	154988736	G	C	154988736	3	2	10	1	0	0	0	0	1	0	0	0	17612	943	33	2	1201	2	ZBTB7B	1	154988736	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	1675868	154988736	94261885	8	610										
DCST1	149095	broad.mit.edu	37	chr1	155013892	155013892	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gagtagcaaagaattgctgaGagcagagactcggaacatct	12	7	1	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:155013892G>A	ENST00000295542.1	+	7	647	c.551G>A	c.(550-552)aGa>aAa	p.R184K	DCST1_ENST00000368419.2_Missense_Mutation_p.R184K|DCST1_ENST00000423025.2_Missense_Mutation_p.R159K|DCST1_ENST00000392480.1_Missense_Mutation_p.R184K	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	184						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GAATTGCTGAGAGCAGAGACT	0.577													5	50					0	0	1	0	0	A	155013892	G	A	155013892	3	1	10	1	0	0	0	0	1	0	0	0	4325	942	33	3	573	3	DCST1	1	155013892	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	25156	155013892	94236729	9	611										
DHX9	1660	broad.mit.edu	37	chr1	182850453	182850453	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	acctgctttccagagcctttCatcaatgaaggaaagcggct	9	11	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:182850453C>T	ENST00000367549.3	+	23	2789	c.2679C>T	c.(2677-2679)ttC>ttT	p.F893F	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	893					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						CAGAGCCTTTCATCAATGAAG	0.438													54	47					0	0	1	0	0	T	182850453	C	T	182850453	2	4	10	1	0	0	0	0	0	0	0	1	4544	825	29	3		3	DHX9	1	182850453	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	27836561	182850453	66400168	10	612										
TMEM81	388730	broad.mit.edu	37	chr1	205053392	205053392	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggtgtagtcaccaccaaaggCaggtagaaggccaaccccag	12	12	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:205053392C>G	ENST00000367167.3	-	1	253	c.57G>C	c.(55-57)ctG>ctC	p.L19L		NM_203376.1	NP_976310.1	Q6P7N7	TMM81_HUMAN	transmembrane protein 81	19						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CCACCAAAGGCAGGTAGAAGG	0.522													36	41					0	0	1	0	0	G	205053392	C	G	205053392	2	3	10	1	0	0	0	0	0	0	0	1	16264	697	25	5		5	TMEM81	1	205053392	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	22202939	205053392	44197229	11	613										
RYR2	6262	broad.mit.edu	37	chr1	237957189	237957189	+	Missense_Mutation	SNP	G	G	C													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cccattggttatttttaagcGagaaaaggaagtggcacgga							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:237957189G>C	ENST00000366574.2	+	95	14122	c.13805G>C	c.(13804-13806)cGa>cCa	p.R4602P	RYR2_ENST00000542537.1_Missense_Mutation_p.R4586P|RYR2_ENST00000360064.6_Missense_Mutation_p.R4608P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4602					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTTTTAAGCGAGAAAAGGAA	0.353													14	11					0	0	1	0	0	C	237957189	G	C	237957189	3	2	10	1	0	0	0	0	1	0	0	0	13820	1058	37	2	14183	2	RYR2	1	237957189	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	32903797	237957189	11293432	12	614	4	2								
RYR2	6262	broad.mit.edu	37	chr1	237957190	237957190	+	Silent	SNP	A	A	G													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccattggttatttttaagcgAgaaaaggaagtggcacggaa							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:237957190A>G	ENST00000366574.2	+	95	14123	c.13806A>G	c.(13804-13806)cgA>cgG	p.R4602R	RYR2_ENST00000542537.1_Silent_p.R4586R|RYR2_ENST00000360064.6_Silent_p.R4608R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4602					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTTTAAGCGAGAAAAGGAAG	0.348													14	11					0	0	1	0	0	G	237957190	A	G	237957190	2	3	10	1	0	0	0	0	0	0	0	1	13820	291	11	4		4	RYR2	1	237957190	Silent	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	1	237957190	11293431	13	615	4	2								
OR2W3	343171	broad.mit.edu	37	chr1	248059114	248059114	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tggacctcagtttcaccaccAgctccatcccccagctgctc	6	19	2	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr1:248059114A>G	ENST00000537741.1	+	3	483	c.226A>G	c.(226-228)Agc>Ggc	p.S76G	OR2W3_ENST00000360358.3_Missense_Mutation_p.S76G			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TTTCACCACCAGCTCCATCCC	0.582													9	213					0	0	1	0	0	G	248059114	A	G	248059114	3	3	10	1	0	0	0	0	1	0	0	0	11080	188	7	4	228	4	OR2W3	1	248059114	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	10101924	248059114	1191507	14	616										
SRBD1	55133	broad.mit.edu	37	chr2	45812822	45812822	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	taatgagctcttttctataaCgtataatgaagggaattgtg	9	4	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:45812822C>G	ENST00000263736.4	-	5	802	c.740G>C	c.(739-741)cGt>cCt	p.R247P		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	247					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TTTTCTATAACGTATAATGAA	0.353													6	34					0	0	1	0	0	G	45812822	C	G	45812822	3	3	10	1	0	0	0	0	1	0	0	0	15188	536	19	5	2315	5	SRBD1	2	45812822	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		45812822	197386551	15	617										
EPAS1	2034	broad.mit.edu	37	chr2	46602865	46602865	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggtagtaagtggccagtaccGgatgctcgcaaagcatgggg	16	8	0	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:46602865G>A	ENST00000263734.3	+	8	1433	c.923G>A	c.(922-924)cGg>cAg	p.R308Q		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	308	PAC.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GGCCAGTACCGGATGCTCGCA	0.602													18	39					0	0	1	0	0	A	46602865	G	A	46602865	3	1	10	1	0	0	0	0	1	0	0	0	5178	1116	39	1	953	1	EPAS1	2	46602865	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	790043	46602865	196596508	16	618										
AFTPH	54812	broad.mit.edu	37	chr2	64780209	64780209	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	acttaaaaatgggcaagaagGtgagattggacattttgatt	11	3	0	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:64780209G>T	ENST00000422803.1	+	2	1915	c.1601G>T	c.(1600-1602)gGt>gTt	p.G534V	AFTPH_ENST00000238856.4_Missense_Mutation_p.G534V|AFTPH_ENST00000409933.1_Missense_Mutation_p.G534V|AFTPH_ENST00000409183.1_Missense_Mutation_p.G165V|AFTPH_ENST00000487769.1_3'UTR|AFTPH_ENST00000238855.7_Missense_Mutation_p.G534V			Q6ULP2	AFTIN_HUMAN	aftiphilin	534					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						GGGCAAGAAGGTGAGATTGGA	0.388													13	45					7.03913e-09	8.17781e-09	1	1	0	T	64780209	G	T	64780209	3	4	10	1	0	0	0	0	1	0	0	0	363	1261	44	5	1603	5	AFTPH	2	64780209	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	18177344	64780209	178419164	17	619										
GMCL1	64395	broad.mit.edu	37	chr2	70096956	70096956	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cactgaatcagccatgtagcGgatctgtcagtttacagcct	9	11	3	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:70096956G>A	ENST00000282570.3	+	12	1575	c.1324G>A	c.(1324-1326)Gga>Aga	p.G442R		NM_178439.3	NP_848526.1	Q96IK5	GMCL1_HUMAN	germ cell-less, spermatogenesis associated 1	442					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	15						GCCATGTAGCGGATCTGTCAG	0.433													13	35					0	0	1	0	0	A	70096956	G	A	70096956	3	1	10	1	0	0	0	0	1	0	0	0	6526	1117	39	1	1370	1	GMCL1	2	70096956	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	5316747	70096956	173102417	18	620										
SLC4A5	57835	broad.mit.edu	37	chr2	74491273	74491273	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccagcgtaaggcctgactcaCttgtggtggagactgacttc	12	11	1	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:74491273C>T	ENST00000394019.2	-	10	1113		c.e10+1		SLC4A5_ENST00000483195.1_Splice_Site|RP11-287D1.3_ENST00000451608.2_Splice_Site|SLC4A5_ENST00000423644.1_Splice_Site|SLC4A5_ENST00000377634.4_Splice_Site|SLC4A5_ENST00000377632.1_Splice_Site|SLC4A5_ENST00000359484.4_Splice_Site|SLC4A5_ENST00000358683.4_Splice_Site|SLC4A5_ENST00000357822.5_Splice_Site|SLC4A5_ENST00000346834.4_Splice_Site	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5							apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GCCTGACTCACTTGTGGTGGA	0.592													17	48					0	0	1	0	0	T	74491273	C	T	74491273	5	4	10	1	0	0	0	0	0	0	1	0	14711	579	20	3	2785	3	SLC4A5	2	74491273	Splice_Site	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	4394317	74491273	168708100	19	621										
RETSAT	54884	broad.mit.edu	37	chr2	85577956	85577956	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ttcctcctgtggaaacttctCcttgaggccctgaatgtagg	10	11	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:85577956C>A	ENST00000295802.4	-	3	656	c.544G>T	c.(544-546)Gag>Tag	p.E182*	RETSAT_ENST00000457495.2_Nonsense_Mutation_p.E121*|RETSAT_ENST00000263854.6_Nonsense_Mutation_p.E182*	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	182					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	GGAAACTTCTCCTTGAGGCCC	0.483													10	108					0.000442599	0.000463117	1	1	0	A	85577956	C	A	85577956	4	1	10	1	0	0	0	0	0	1	0	0	13289	864	30	2	1324	2	RETSAT	2	85577956	Nonsense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	11086683	85577956	157621417	20	622										
MAT2A	4144	broad.mit.edu	37	chr2	85768241	85768241	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aaatcagtgatgctgtccttGatgcccaccttcagcaggat	9	11	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:85768241G>C	ENST00000306434.3	+	2	250	c.127G>C	c.(127-129)Gat>Cat	p.D43H	MAT2A_ENST00000409017.1_5'UTR	NM_005911.5	NP_005902.1	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	43					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	9					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGCTGTCCTTGATGCCCACCT	0.368													18	77					0	0	1	0	0	C	85768241	G	C	85768241	3	2	10	1	0	0	0	0	1	0	0	0	9379	1290	45	2	133	2	MAT2A	2	85768241	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	190285	85768241	157431132	21	623										
POLR1A	25885	broad.mit.edu	37	chr2	86274381	86274381	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ctgtgtaggccaaaaggcatGcatgcctgcagattaaatca	10	9	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:86274381G>T	ENST00000263857.6	-	19	3018	c.2640C>A	c.(2638-2640)tgC>tgA	p.C880*	POLR1A_ENST00000409681.1_Nonsense_Mutation_p.C880*			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	880					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						CAAAAGGCATGCATGCCTGCA	0.478													6	37					3.59834e-05	3.94817e-05	1	1	0	T	86274381	G	T	86274381	4	4	10	1	0	0	0	0	0	1	0	0	12256	1311	46	5	2586	5	POLR1A	2	86274381	Nonsense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	506140	86274381	156924992	22	624										
IL1B	3553	broad.mit.edu	37	chr2	113588102	113588102	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gatttctatcttgttgaagaCaaatcgcttttccatcttct	5	9	4	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:113588102C>A	ENST00000263341.2	-	7	856	c.646G>T	c.(646-648)Gtc>Ttc	p.V216F	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	216					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	TTGTTGAAGACAAATCGCTTT	0.423													5	88					0.0215528	0.0218291	1	1	0	A	113588102	C	A	113588102	3	1	10	1	0	0	0	0	1	0	0	0	7694	478	17	5	167	5	IL1B	2	113588102	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	27313721	113588102	129611271	23	625										
TTN	7273	broad.mit.edu	37	chr2	179639016	179639016	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tcctccttggttacatccttGaccgtgaggttctgacgtcc	9	13	1	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:179639016G>C	ENST00000589042.1	-	30	7199	c.6975C>G	c.(6973-6975)gtC>gtG	p.V2325V	TTN_ENST00000591111.1_Silent_p.V2325V|TTN-AS1_ENST00000584485.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V2279V|TTN_ENST00000360870.5_Silent_p.V2325V|TTN_ENST00000359218.5_Silent_p.V2279V|TTN_ENST00000342992.6_Silent_p.V2325V|TTN_ENST00000342175.6_Silent_p.V2279V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2042	Ig-like 12.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACATCCTTGACCGTGAGGT	0.408													20	52					0	0	1	0	0	C	179639016	G	C	179639016	2	2	10	1	0	0	0	0	0	0	0	1	16796	1277	45	2		2	TTN	2	179639016	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	66050914	179639016	63560357	24	626										
SF3B1	23451	broad.mit.edu	37	chr2	198285262	198285262	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gtctgtgctcagcaaatggaTcatactgaaaagaggtatgt	11	6	3	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr2:198285262T>G	ENST00000335508.5	-	4	396	c.305A>C	c.(304-306)gAt>gCt	p.D102A	SF3B1_ENST00000487698.1_Missense_Mutation_p.D102A|SF3B1_ENST00000409915.4_Missense_Mutation_p.D102A|SF3B1_ENST00000414963.2_Missense_Mutation_p.D102A	NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	102					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGCAAATGGATCATACTGAAA	0.368			Mis		myelodysplastic syndrome								38	17					0	0	1	0	0	G	198285262	T	G	198285262	3	3	10	1	0	0	0	0	1	0	0	0	14202	1435	50	4	3721	4	SF3B1	2	198285262	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	18646246	198285262	44914111	25	627										
NBEAL2	23218	broad.mit.edu	37	chr3	47035510	47035510	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	agtgactccccctcggccaaGgtgaggctgctgcactgcag	13	14	0	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr3:47035510G>C	ENST00000450053.3	+	11	1376	c.1197_splice	c.e11+1	p.K399_splice	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Splice_Site_p.K399_splice	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	399							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCTCGGCCAAGGTGAGGCTGC	0.602													3	16					0	0	1	0	0	C	47035510	G	C	47035510	5	2	10	1	0	0	0	0	0	0	1	0	10236	1014	35	5	1239	5	NBEAL2	3	47035510	Splice_Site	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08		47035510	150986920	26	628										
CPNE4	131034	broad.mit.edu	37	chr3	131404727	131404727	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gatgactcttacctcagttcGgtgcaccagctgctgagttg	11	11	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr3:131404727G>A	ENST00000512055.1	-	10	2709	c.583C>T	c.(583-585)Cga>Tga	p.R195*	CPNE4_ENST00000511604.1_Nonsense_Mutation_p.R195*|CPNE4_ENST00000502818.1_Nonsense_Mutation_p.R213*|CPNE4_ENST00000512332.1_Nonsense_Mutation_p.R213*|CPNE4_ENST00000429747.1_Nonsense_Mutation_p.R195*			Q96A23	CPNE4_HUMAN	copine IV	195	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						ACCTCAGTTCGGTGCACCAGC	0.378													17	27					0	0	1	0	0	A	131404727	G	A	131404727	4	1	10	1	0	0	0	0	0	1	0	0	3837	1124	39	1	1134	1	CPNE4	3	131404727	Nonsense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	84369217	131404727	66617703	27	629										
ZBTB38	253461	broad.mit.edu	37	chr3	141163673	141163673	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ttgctgaagaaaccagcaaaAttgaaacctacattgcaaaa	6	8	0	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr3:141163673A>G	ENST00000514251.1	+	4	2722	c.2443A>G	c.(2443-2445)Att>Gtt	p.I815V	ZBTB38_ENST00000321464.5_Missense_Mutation_p.I816V|ZBTB38_ENST00000441582.2_Missense_Mutation_p.I815V			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	815					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						AACCAGCAAAATTGAAACCTA	0.433													6	75					0	0	1	0	0	G	141163673	A	G	141163673	3	3	10	1	0	0	0	0	1	0	0	0	17597	101	4	4	2445	4	ZBTB38	3	141163673	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	9758946	141163673	56858757	28	630										
BCHE	590	broad.mit.edu	37	chr3	165547849	165547849	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tggcatgtcagtgagaaaatCaccatccacggtcggaccaa	10	11	2	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr3:165547849C>A	ENST00000264381.3	-	2	1139	c.973G>T	c.(973-975)Gat>Tat	p.D325Y	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	325					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	GTGAGAAAATCACCATCCACG	0.383													60	2					1.54043e-34	1.96281e-34	1	1	0	A	165547849	C	A	165547849	3	1	10	1	0	0	0	0	1	0	0	0	1356	826	29	2	847	2	BCHE	3	165547849	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	24384176	165547849	32474581	29	631										
PIK3CA	5290	broad.mit.edu	37	chr3	178921552	178921552	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tctttgtgcaacctacgtgaAtgtaaatattcgagacattg	8	7	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr3:178921552A>T	ENST00000263967.3	+	5	1191	c.1034A>T	c.(1033-1035)aAt>aTt	p.N345I		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345I(4)|p.N345S(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACCTACGTGAATGTAAATATT	0.303		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			70	2					0	0	1	0	0	T	178921552	A	T	178921552	3	4	10	1	0	0	0	0	1	0	0	0	11960	101	4	4	1048	4	PIK3CA	3	178921552	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	13373703	178921552	19100878	30	632										
SLC26A1	10861	broad.mit.edu	37	chr4	982659	982659	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggcctccagctccctgtggcGggctcgtgctgtctgcacgg	15	15	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:982659G>A	ENST00000361661.2	-	4	2445	c.2068C>T	c.(2068-2070)Cgc>Tgc	p.R690C	SLC26A1_ENST00000398520.2_Intron|IDUA_ENST00000509744.1_Intron|IDUA_ENST00000453894.1_Intron|SLC26A1_ENST00000398516.2_Missense_Mutation_p.R690C|IDUA_ENST00000247933.4_Intron	NM_213613.2	NP_998778.1	Q9H2B4	S26A1_HUMAN	solute carrier family 26 (anion exchanger), member 1	690						integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|pancreas(1)|prostate(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TCCCTGTGGCGGGCTCGTGCT	0.677													3	23					0	0	1	0	0	A	982659	G	A	982659	3	1	10	1	0	0	0	0	1	0	0	0	14568	1116	39	1	144	1	SLC26A1	4	982659	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08		982659	190171617	31	633										
TACC3	10460	broad.mit.edu	37	chr4	1729792	1729792	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gagactccgcacggagccgaGgaagaatgcaaagcggagac	15	10	0	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:1729792G>C	ENST00000313288.4	+	4	769	c.663G>C	c.(661-663)gaG>gaC	p.E221D		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	221						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			ACGGAGCCGAGGAAGAATGCA	0.617													16	123					0	0	1	0	0	C	1729792	G	C	1729792	3	2	10	1	0	0	0	0	1	0	0	0	15559	991	35	5	673	5	TACC3	4	1729792	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	747133	1729792	189424484	32	634										
ZNF518B	85460	broad.mit.edu	37	chr4	10445496	10445496	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aaaggctgtaagtctgagtcCgcctgtctcacagggcaaaa	11	10	2	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:10445496C>T	ENST00000326756.3	-	3	2895	c.2457G>A	c.(2455-2457)gcG>gcA	p.A819A		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	819					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						AGTCTGAGTCCGCCTGTCTCA	0.468													18	73					0	0	1	0	0	T	10445496	C	T	10445496	2	4	10	1	0	0	0	0	0	0	0	1	18019	639	23	1		1	ZNF518B	4	10445496	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	8715704	10445496	180708780	33	635										
GBA3	57733	broad.mit.edu	37	chr4	22729287	22729287	+	RNA	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gagttatctcaggcacccacTtttctttcacattttcaaat	4	11	4	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:22729287T>G	ENST00000508166.1	+	0	160				GBA3_ENST00000511446.1_RNA|GBA3_ENST00000503442.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGGCACCCACTTTTCTTTCAC	0.403													23	183					0	0	1	0	0	G	22729287	T	G	22729287	1	3	10	0	1	0	0	0	0	0	0	0	6307	1624	56	4		4	GBA3	4	22729287	RNA	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	12283791	22729287	168424989	34	636										
PPARGC1A	10891	broad.mit.edu	37	chr4	23886369	23886369	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ttaatgtttccaaaggatgtCcttacctcaaatatgtttga	6	7	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:23886369C>G	ENST00000507380.1	-	2	317	c.240G>C	c.(238-240)agG>agC	p.R80S	PPARGC1A_ENST00000264867.2_Intron			Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				CAAAGGATGTCCTTACCTCAA	0.388													19	39					0	0	1	0	0	G	23886369	C	G	23886369	3	3	10	1	0	0	0	0	1	0	0	0	12344	870	30	2		2	PPARGC1A	4	23886369	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	1157082	23886369	167267907	35	637										
ADAMTS3	9508	broad.mit.edu	37	chr4	73205322	73205322	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ttgtaatcgttttctcccgcGtgtctgcggcgtctcattgt	10	11	3	0	rs142264188		TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:73205322G>C	ENST00000286657.4	-	5	786	c.750C>G	c.(748-750)caC>caG	p.H250Q		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	250					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTTCTCCCGCGTGTCTGCGGC	0.502													6	247					0	0	1	0	0	C	73205322	G	C	73205322	3	2	10	1	0	0	0	0	1	0	0	0	266	1136	40	5	2939	5	ADAMTS3	4	73205322	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	49318953	73205322	117948954	36	638										
COX18	285521	broad.mit.edu	37	chr4	73930519	73930519	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	actattaacaaattgatgacGccaacagagataggcagaat	8	7	0	4	rs61741433	byFrequency	TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:73930519G>A	ENST00000295890.4	-	4	787	c.696C>T	c.(694-696)ggC>ggT	p.G232G	COX18_ENST00000507544.2_Silent_p.G233G	NM_173827.2	NP_776188.1	Q8N8Q8	COX18_HUMAN	COX18 cytochrome C oxidase assembly factor	232					protein insertion into mitochondrial membrane|respiratory chain complex IV assembly	integral to mitochondrial inner membrane	protein transporter activity			large_intestine(4)|lung(2)	6	Breast(15;0.00096)		Epithelial(6;1.26e-06)|OV - Ovarian serous cystadenocarcinoma(6;9.45e-06)|all cancers(17;2.05e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATTGATGACGCCAACAGAGA	0.408													4	66					0	0	1	0	0	A	73930519	G	A	73930519	2	1	10	1	0	0	0	0	0	0	0	1	3790	1074	38	1		1	COX18	4	73930519	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	725197	73930519	117223757	37	639										
PRDM5	11107	broad.mit.edu	37	chr4	121739545	121739545	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cttaactgggaatttcttccCacagttcttgcacttaaatt	5	10	2	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:121739545C>A	ENST00000264808.3	-	5	853	c.613G>T	c.(613-615)Ggg>Tgg	p.G205W	PRDM5_ENST00000515109.1_Missense_Mutation_p.G205W|PRDM5_ENST00000428209.2_Missense_Mutation_p.G205W	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	205					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AATTTCTTCCCACAGTTCTTG	0.373													9	17					0.000442599	0.000463117	1	1	0	A	121739545	C	A	121739545	3	1	10	1	0	0	0	0	1	0	0	0	12511	594	21	5	1327	5	PRDM5	4	121739545	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	47809026	121739545	69414731	38	640										
TBC1D9	23158	broad.mit.edu	37	chr4	141578966	141578966	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	caccttggtccaccagtgcaCctgtggcagcgatgtataca	10	13	0	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:141578966C>T	ENST00000442267.2	-	12	1996	c.1921_splice	c.e12-1	p.G641_splice		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	641	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CACCAGTGCACCTGTGGCAGC	0.502													41	78					0	0	1	0	0	T	141578966	C	T	141578966	5	4	10	1	0	0	0	0	0	0	1	0	15686	521	18	3	1918	3	TBC1D9	4	141578966	Splice_Site	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	19839421	141578966	49575310	39	641										
FBXW7	0	broad.mit.edu	37	chr4	153250906	153250906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	taccacaaaactgtaagcatGtgatcacatgatcatcatgt	6	9	3	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr4:153250906G>A	ENST00000281708.4	-	8	2383	c.1154C>T	c.(1153-1155)aCa>aTa	p.T385I	FBXW7_ENST00000603841.1_Missense_Mutation_p.T385I|FBXW7_ENST00000263981.5_Missense_Mutation_p.T305I|FBXW7_ENST00000296555.5_Missense_Mutation_p.T267I|FBXW7_ENST00000393956.3_Missense_Mutation_p.T209I|FBXW7_ENST00000603548.1_Missense_Mutation_p.T385I	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	385					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTGTAAGCATGTGATCACATG	0.343			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								24	17					0	0	1	0	0	A	153250906	G	A	153250906	3	1	10	1	0	0	0	0	1	0	0	0	5801	1377	48	3	989	3	FBXW7	4	153250906	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	11671940	153250906	37903370	40	642										
CLPTM1L	81037	broad.mit.edu	37	chr5	1318557	1318557	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cgttcactctgcgtttatccAcaggataaagcctgcaatga	8	11	2	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr5:1318557A>C	ENST00000320895.5	-	17	1801	c.1544T>G	c.(1543-1545)gTg>gGg	p.V515G	CLPTM1L_ENST00000507807.1_Missense_Mutation_p.V346G|CLPTM1L_ENST00000506641.1_5'UTR|CLPTM1L_ENST00000320927.6_Missense_Mutation_p.V479G	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	515					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GCGTTTATCCACAGGATAAAG	0.562													7	63					0	0	1	0	0	C	1318557	A	C	1318557	3	2	10	1	0	0	0	0	1	0	0	0	3578	159	6	4	76	4	CLPTM1L	5	1318557	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08		1318557	179596703	41	643										
PRDM9	56979	broad.mit.edu	37	chr5	23526781	23526781	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gcaaaagtcaagtatggagaGtgtggacaaggtttcagtgt	14	4	2	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr5:23526781G>A	ENST00000296682.3	+	11	1766	c.1584G>A	c.(1582-1584)gaG>gaA	p.E528E		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	528					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGTATGGAGAGTGTGGACAAG	0.458										HNSCC(3;0.000094)			49	55					0	0	1	0	0	A	23526781	G	A	23526781	2	1	10	1	0	0	0	0	0	0	0	1	12514	1020	36	3		3	PRDM9	5	23526781	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	22208224	23526781	157388479	42	644										
CDH9	1007	broad.mit.edu	37	chr5	26881282	26881282	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	catcacccccatacatatcgGcaagttttttgaaacgaggc	7	12	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr5:26881282G>A	ENST00000231021.4	-	12	2505	c.2333C>T	c.(2332-2334)gCc>gTc	p.A778V		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	778					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ATACATATCGGCAAGTTTTTT	0.413													129	67					0	0	1	0	0	A	26881282	G	A	26881282	3	1	10	1	0	0	0	0	1	0	0	0	3139	1203	42	3	40	3	CDH9	5	26881282	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	3354501	26881282	154033978	43	645										
PDZD2	23037	broad.mit.edu	37	chr5	32074556	32074556	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gcagaaaagtgaaggcctggGctccaggcacagaccagtgg	15	10	0	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr5:32074556G>A	ENST00000438447.1	+	18	3732	c.3344G>A	c.(3343-3345)gGc>gAc	p.G1115D	PDZD2_ENST00000282493.3_Missense_Mutation_p.G1115D			O15018	PDZD2_HUMAN	PDZ domain containing 2	1115					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GAAGGCCTGGGCTCCAGGCAC	0.597													5	213					0	0	1	0	0	A	32074556	G	A	32074556	3	1	10	1	0	0	0	0	1	0	0	0	11747	1203	42	3	3410	3	PDZD2	5	32074556	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	5193274	32074556	148840704	44	646										
HCN1	348980	broad.mit.edu	37	chr5	45396744	45396744	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	actggggcttgggctccataCccaatgcacagcatgtgact	11	12	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr5:45396744C>A	ENST00000303230.4	-	4	1137	c.1080G>T	c.(1078-1080)ggG>ggT	p.G360G		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	360						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GGGCTCCATACCCAATGCACA	0.478													29	95					4.87955e-14	5.93054e-14	1	1	0	A	45396744	C	A	45396744	2	1	10	1	0	0	0	0	0	0	0	1	7036	494	18	5		5	HCN1	5	45396744	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	13322188	45396744	135518516	45	647										
DSP	1832	broad.mit.edu	37	chr6	7581043	7581043	+	Frame_Shift_Del	DEL	C	C	-													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gaactgacacgcctgaggatCgactatgaaagggtttccca							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr6:7581043delC	ENST00000379802.3	+	23	4961	c.4620delC	c.(4618-4620)atfs	p.I1540fs	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1540	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCCTGAGGATCGACTATGAAA	0.502													66	177	---	---	---	---						-	7581043	C	-	7581043	7	5	10	1	0	1	0	1	0	0	0	0	4807	874	31	0	4710	0	DSP	6	7581043	Frame_Shift_Del	DEL	C	TCGA-N5-A4RT-01A-11D-A28R-08		7581043	163534024	46	648										
HCRTR2	3062	broad.mit.edu	37	chr6	55142223	55142223	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	agagaaaatggaagcccctgCagcctgtttcacagcctcga	10	12	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr6:55142223C>A	ENST00000370862.3	+	5	1144	c.808C>A	c.(808-810)Cag>Aag	p.Q270K		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	270					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GAAGCCCCTGCAGCCTGTTTC	0.507													14	47					0.000151284	0.000161506	1	1	0	A	55142223	C	A	55142223	3	1	10	1	0	0	0	0	1	0	0	0	7042	711	25	5	826	5	HCRTR2	6	55142223	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	47561180	55142223	115972844	47	649										
COL19A1	1310	broad.mit.edu	37	chr6	70646733	70646733	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tcatgggtaactgctcatgcCagtaaaatgtcttcatatct	7	9	5	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr6:70646733C>A	ENST00000322773.4	+	8	906	c.804C>A	c.(802-804)gcC>gcA	p.A268A		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	268					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CTGCTCATGCCAGTAAAATGT	0.418													6	83					3.59834e-05	3.94817e-05	1	1	0	A	70646733	C	A	70646733	2	1	10	1	0	0	0	0	0	0	0	1	3699	581	21	5		5	COL19A1	6	70646733	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	15504510	70646733	100468334	48	650										
SLC17A5	26503	broad.mit.edu	37	chr6	74363526	74363526	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cgccgcttaccggcttcggcCcgtggggcgcccggtagaag	16	15	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr6:74363526C>A	ENST00000355773.5	-	1	352	c.84G>T	c.(82-84)cgG>cgT	p.R28R	SLC17A5_ENST00000393019.3_Silent_p.R28R	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	28					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGGCTTCGGCCCGTGGGGCGC	0.726													3	6					0.115264	0.115264	1	1	0	A	74363526	C	A	74363526	2	1	10	1	0	0	0	0	0	0	0	1	14474	610	22	5		5	SLC17A5	6	74363526	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	3716793	74363526	96751541	49	651										
REV3L	5980	broad.mit.edu	37	chr6	111650901	111650901	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	taaatctagtcttcaaaattTcttcaagcattcttggtagt	5	7	6	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr6:111650901T>G	ENST00000435970.1	-	27	8657	c.7841A>C	c.(7840-7842)gAa>gCa	p.E2614A	REV3L_ENST00000368805.1_Missense_Mutation_p.E2692A|REV3L_ENST00000358835.3_Missense_Mutation_p.E2692A|REV3L_ENST00000368802.3_Missense_Mutation_p.E2692A			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2692					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTCAAAATTTCTTCAAGCAT	0.363								DNA polymerases (catalytic subunits)					27	27					0	0	1	0	0	G	111650901	T	G	111650901	3	3	10	1	0	0	0	0	1	0	0	0	13291	1783	62	4	1349	4	REV3L	6	111650901	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	37287375	111650901	59464166	50	652										
MAD1L1	8379	broad.mit.edu	37	chr7	1997278	1997278	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cctcacctgcagagctcgccGctccagctgtgcctccagca	9	19	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr7:1997278G>C	ENST00000406869.1	-	16	2139	c.1582C>G	c.(1582-1584)Cgg>Ggg	p.R528G	MAD1L1_ENST00000265854.7_Missense_Mutation_p.R528G|MAD1L1_ENST00000402746.1_Missense_Mutation_p.R436G|MAD1L1_ENST00000399654.2_Missense_Mutation_p.R528G			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	528	Necessary for interaction with NEK2.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		AGAGCTCGCCGCTCCAGCTGT	0.637													10	83					0	0	1	0	0	C	1997278	G	C	1997278	3	2	10	1	0	0	0	0	1	0	0	0	9192	1086	38	5	590	5	MAD1L1	7	1997278	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08		1997278	157141385	51	653										
HOXA4	3201	broad.mit.edu	37	chr7	27169062	27169062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	agacaaacagagcgtgtgggCgatctcgatgcggcgccgcc	15	12	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr7:27169062C>T	ENST00000360046.5	-	2	810	c.745G>A	c.(745-747)Gcc>Acc	p.A249T	HOXA3_ENST00000467897.2_5'UTR|HOXA4_ENST00000428284.2_Missense_Mutation_p.A249T|HOXA-AS2_ENST00000521159.1_RNA	NM_002141.4	NP_002132.3	Q00056	HXA4_HUMAN	homeobox A4	249						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)	12						AGCGTGTGGGCGATCTCGATG	0.572													56	60					0	0	1	0	0	T	27169062	C	T	27169062	3	4	10	1	0	0	0	0	1	0	0	0	7334	768	27	1	221	1	HOXA4	7	27169062	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	25171784	27169062	131969601	52	654										
NPC1L1	29881	broad.mit.edu	37	chr7	44574199	44574199	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cccaggaccacggccaccccGccgaggcccagcgtggcctt	12	20	0	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr7:44574199G>T	ENST00000289547.4	-	6	2068	c.2013C>A	c.(2011-2013)ggC>ggA	p.G671G	NPC1L1_ENST00000546276.1_Silent_p.G671G|NPC1L1_ENST00000423141.1_Silent_p.G671G|NPC1L1_ENST00000381160.3_Silent_p.G671G	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	671	SSD.				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CGGCCACCCCGCCGAGGCCCA	0.622											OREG0018038	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	60					6.49762e-13	7.71898e-13	1	1	0	T	44574199	G	T	44574199	2	4	10	1	0	0	0	0	0	0	0	1	10617	1074	38	5		5	NPC1L1	7	44574199	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	17405137	44574199	114564464	53	655										
MUC17	140453	broad.mit.edu	37	chr7	100677014	100677014	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccctttcaacaactcctcttGacacaagcacacatatcacc	2	17	3	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr7:100677014G>A	ENST00000306151.4	+	3	2381	c.2317G>A	c.(2317-2319)Gac>Aac	p.D773N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	773	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.D773N(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTCTTGACACAAGCAC	0.478													112	272					0	0	1	0	0	A	100677014	G	A	100677014	3	1	10	1	0	0	0	0	1	0	0	0	10021	1290	45	3	2327	3	MUC17	7	100677014	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	56102815	100677014	58461649	54	656										
TRIM56	81844	broad.mit.edu	37	chr7	100730756	100730756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tggcggatggcggccgcgtcCgctgccccgagtgccgcgag	18	15	0	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr7:100730756C>T	ENST00000306085.6	+	3	460	c.163C>T	c.(163-165)Cgc>Tgc	p.R55C		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	55					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CGGCCGCGTCCGCTGCCCCGA	0.647													27	72					0	0	1	0	0	T	100730756	C	T	100730756	3	4	10	1	0	0	0	0	1	0	0	0	16590	652	23	1	165	1	TRIM56	7	100730756	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	53742	100730756	58407907	55	657										
EXTL3	2137	broad.mit.edu	37	chr8	28574908	28574908	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gaccctcgcttggttatttcCtctgggtgtgcaacacggct	11	12	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr8:28574908C>T	ENST00000220562.4	+	3	2234	c.1332C>T	c.(1330-1332)tcC>tcT	p.S444S	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Silent_p.S60S	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	444						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TGGTTATTTCCTCTGGGTGTG	0.617													4	62					0	0	1	0	0	T	28574908	C	T	28574908	2	4	10	1	0	0	0	0	0	0	0	1	5355	668	24	3		3	EXTL3	8	28574908	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		28574908	117789114	56	658										
ASH2L	9070	broad.mit.edu	37	chr8	37985968	37985968	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tgccagactgggttggtcccAgcccctaggtaagctggggc	15	12	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr8:37985968A>T	ENST00000343823.6	+	11	1634	c.1325A>T	c.(1324-1326)cAg>cTg	p.Q442L	ASH2L_ENST00000521652.1_Missense_Mutation_p.Q348L|ASH2L_ENST00000428278.2_Missense_Mutation_p.Q348L|ASH2L_ENST00000250635.7_Missense_Mutation_p.Q348L|ASH2L_ENST00000545394.1_Missense_Mutation_p.Q303L	NM_004674.4	NP_004665.2	Q9UBL3	ASH2L_HUMAN	ash2 (absent, small, or homeotic)-like (Drosophila)	442	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)	19	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				GGTTGGTCCCAGCCCCTAGGT	0.527													36	25					0	0	1	0	0	T	37985968	A	T	37985968	3	4	10	1	0	0	0	0	1	0	0	0	1041	188	7	4	1367	4	ASH2L	8	37985968	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	9411060	37985968	108378054	57	659										
LETM2	137994	broad.mit.edu	37	chr8	38260158	38260158	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	acaactgcgacaacagctcaCggaggcaagtagcagcgccc	11	14	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr8:38260158C>A	ENST00000379957.4	+	7	1227	c.1100C>A	c.(1099-1101)aCg>aAg	p.T367K	LETM2_ENST00000524874.1_Missense_Mutation_p.T319K|LETM2_ENST00000527710.1_Missense_Mutation_p.T153K|LETM2_ENST00000297720.5_Missense_Mutation_p.T272K|LETM2_ENST00000523983.2_Missense_Mutation_p.T320K|LETM2_ENST00000528827.1_3'UTR	NM_001199659.1	NP_001186588.1	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane protein 2	367	LETM1.					integral to membrane|mitochondrial inner membrane				NS(1)|large_intestine(1)|lung(3)|prostate(2)	7	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			CAACAGCTCACGGAGGCAAGT	0.542													22	51					7.3207e-31	9.25336e-31	1	1	0	A	38260158	C	A	38260158	3	1	10	1	0	0	0	0	1	0	0	0	8773	536	19	5	829	5	LETM2	8	38260158	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	274190	38260158	108103864	58	660										
RP1	6101	broad.mit.edu	37	chr8	55533846	55533846	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cggcgagtcctacctatgttCccacggcaggaaggtgcagc	13	13	0	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr8:55533846C>A	ENST00000220676.1	+	2	468	c.320C>A	c.(319-321)tCc>tAc	p.S107Y		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	107	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TACCTATGTTCCCACGGCAGG	0.677													9	98					0.00621372	0.00637511	1	1	0	A	55533846	C	A	55533846	3	1	10	1	0	0	0	0	1	0	0	0	13583	855	30	2	322	2	RP1	8	55533846	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	17273688	55533846	90830176	59	661										
CSMD3	114788	broad.mit.edu	37	chr8	113318340	113318340	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gatatccatcattacaaaaaTaggtaactcgcgttcctacc	5	11	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr8:113318340T>C	ENST00000297405.5	-	51	8211	c.7967A>G	c.(7966-7968)tAt>tGt	p.Y2656C	CSMD3_ENST00000343508.3_Missense_Mutation_p.Y2616C|CSMD3_ENST00000352409.3_Missense_Mutation_p.Y2586C|CSMD3_ENST00000455883.2_Missense_Mutation_p.Y2552C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2656	Sushi 15.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTACAAAAATAGGTAACTCG	0.403										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	35					0	0	1	0	0	C	113318340	T	C	113318340	3	2	10	1	0	0	0	0	1	0	0	0	3971	1406	49	4	3240	4	CSMD3	8	113318340	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	57784494	113318340	33045682	60	662										
ENPP2	0	broad.mit.edu	37	chr8	120599309	120599309	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gattggcaataatggctttgGggtcatctgttcaaagagag	13	5	3	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr8:120599309G>C	ENST00000427067.2	-	14	1382	c.1202C>G	c.(1201-1203)cCc>cGc	p.P401R	ENPP2_ENST00000075322.6_Missense_Mutation_p.P405R|ENPP2_ENST00000522826.1_Missense_Mutation_p.P405R|ENPP2_ENST00000522167.1_Missense_Mutation_p.P44R|ENPP2_ENST00000259486.6_Missense_Mutation_p.P457R			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	405					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATGGCTTTGGGGTCATCTGT	0.478													5	13					0	0	1	0	0	C	120599309	G	C	120599309	3	2	10	1	0	0	0	0	1	0	0	0	5158	1232	43	5	1504	5	ENPP2	8	120599309	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	7280969	120599309	25764713	61	663										
FOXD4	2298	broad.mit.edu	37	chr9	117617	117617	+	Missense_Mutation	SNP	T	T	C													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccttgcctgggcggcccggcTcgcgggggatcttgacgaag							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:117617T>C	ENST00000382500.2	-	1	800	c.503A>G	c.(502-504)gAg>gGg	p.E168G		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	168					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCGGCCCGGCTCGCGGGGGAT	0.637													7	405					0	0	1	0	0	C	117617	T	C	117617	3	2	10	1	0	0	0	0	1	0	0	0	6031	1551	54	4	820	4	FOXD4	9	117617	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08		117617	141095814	62	664	5	2								
FOXD4	2298	broad.mit.edu	37	chr9	117618	117618	+	Missense_Mutation	SNP	C	C	T													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cttgcctgggcggcccggctCgcgggggatcttgacgaagc							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:117618C>T	ENST00000382500.2	-	1	799	c.502G>A	c.(502-504)Gag>Aag	p.E168K		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	168					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CGGCCCGGCTCGCGGGGGATC	0.632													7	405					0	0	1	0	0	T	117618	C	T	117618	3	4	10	1	0	0	0	0	1	0	0	0	6031	893	31	1	821	1	FOXD4	9	117618	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	1	117618	141095813	63	665	5	2								
OR2S2	56656	broad.mit.edu	37	chr9	35957351	35957351	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggtcccgtagaagacgatcaCcacggtgaggtgggcagagc	16	10	1	4			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:35957351C>G	ENST00000341959.2	-	1	800	c.745G>C	c.(745-747)Gtg>Ctg	p.V249L		NM_019897.2	NP_063950.2	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S, member 2	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)			AAGACGATCACCACGGTGAGG	0.507													61	47					0	0	1	0	0	G	35957351	C	G	35957351	3	3	10	1	0	0	0	0	1	0	0	0	11062	507	18	5	218	5	OR2S2	9	35957351	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	35839733	35957351	105256080	64	666										
COL15A1	1306	broad.mit.edu	37	chr9	101832029	101832029	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	taactactgtgaagcatggcGaaccgcggacacagcggtca	12	11	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:101832029G>T	ENST00000375001.3	+	42	4451	c.4028G>T	c.(4027-4029)cGa>cTa	p.R1343L		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1343	Nonhelical region 10 (NC10).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GAAGCATGGCGAACCGCGGAC	0.527													13	102					0.00010058	0.000108106	1	1	0	T	101832029	G	T	101832029	3	4	10	1	0	0	0	0	1	0	0	0	3695	1058	37	2	4194	2	COL15A1	9	101832029	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	65874678	101832029	39381402	65	667										
LPPR1	0	broad.mit.edu	37	chr9	104086318	104086318	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gctccacagaatcactctgcGtccatgaccgaagttacctg	8	14	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:104086318G>A	ENST00000374874.3	+	8	1396	c.957G>A	c.(955-957)gcG>gcA	p.A319A	LPPR1_ENST00000395056.2_Silent_p.A319A	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		319						integral to membrane	catalytic activity										ATCACTCTGCGTCCATGACCG	0.413													6	12					0	0	1	0	0	A	104086318	G	A	104086318	2	1	10	1	0	0	0	0	0	0	0	1	8968	1132	40	1		1	LPPR1	9	104086318	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	2254289	104086318	37127113	66	668										
POMT1	10585	broad.mit.edu	37	chr9	134379641	134379641	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aagcgccctgtagtggtgacGgctgacatcaacttgagcct	12	11	1	3	rs138334962	by1000genomes	TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:134379641G>C	ENST00000423007.1	+	2	478	c.36G>C	c.(34-36)acG>acC	p.T12T	POMT1_ENST00000419118.2_Intron|POMT1_ENST00000341012.7_Intron|POMT1_ENST00000402686.3_Silent_p.T12T|POMT1_ENST00000541219.1_Intron|POMT1_ENST00000354713.4_Silent_p.T12T|POMT1_ENST00000372228.3_Silent_p.T12T|POMT1_ENST00000404875.2_Intron	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	12					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TAGTGGTGACGGCTGACATCA	0.577											OREG0019563	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	5					0	0	1	0	0	C	134379641	G	C	134379641	2	2	10	1	0	0	0	0	0	0	0	1	12292	1103	39	5		5	POMT1	9	134379641	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	30293323	134379641	6833790	67	669										
CACNA1B	774	broad.mit.edu	37	chr9	140772533	140772533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tcctctacaagcaatcgatcGcgcagcgcgcgcggaccatg	11	15	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr9:140772533G>A	ENST00000371372.1	+	1	293	c.148G>A	c.(148-150)Gcg>Acg	p.A50T	RP11-188C12.3_ENST00000371390.1_RNA|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371355.4_Missense_Mutation_p.A50T|CACNA1B_ENST00000371363.1_Missense_Mutation_p.A50T|CACNA1B_ENST00000371357.1_Missense_Mutation_p.A50T|CACNA1B_ENST00000277551.2_Missense_Mutation_p.A50T	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	50					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GCAATCGATCGCGCAGCGCGC	0.731													6	10					0	0	1	0	0	A	140772533	G	A	140772533	3	1	10	1	0	0	0	0	1	0	0	0	2557	1087	38	1	150	1	CACNA1B	9	140772533	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	6392892	140772533	440898	68	670										
CUBN	8029	broad.mit.edu	37	chr10	16882348	16882348	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cctgcggtgagtcctgaagcTgtaagtaattctgcgtgcag	13	9	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr10:16882348T>G	ENST00000377833.4	-	62	10078	c.10013A>C	c.(10012-10014)cAg>cCg	p.Q3338P		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3338	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTCCTGAAGCTGTAAGTAATT	0.448													21	38					0	0	1	0	0	G	16882348	T	G	16882348	3	3	10	1	0	0	0	0	1	0	0	0	4074	1580	55	4	882	4	CUBN	10	16882348	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08		16882348	118652399	69	671										
MGEA5	10724	broad.mit.edu	37	chr10	103547200	103547200	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gttacttttttgtgaatgtcCatctttatcagagaagggaa	9	5	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr10:103547200C>G	ENST00000361464.3	-	15	2930	c.2535G>C	c.(2533-2535)atG>atC	p.M845I	MGEA5_ENST00000357797.5_Missense_Mutation_p.M778I|MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000439817.1_Missense_Mutation_p.M792I	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	845	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TGTGAATGTCCATCTTTATCA	0.393													45	4					0	0	1	0	0	G	103547200	C	G	103547200	3	3	10	1	0	0	0	0	1	0	0	0	9603	594	21	5	223	5	MGEA5	10	103547200	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	86664852	103547200	31987547	70	672										
CDHR5	53841	broad.mit.edu	37	chr11	621243	621243	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tgggttccacattctcccccGgagtgtcctgcaacagacgg	11	14	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr11:621243G>A	ENST00000358353.3	-	8	948	c.626C>T	c.(625-627)cCg>cTg	p.P209L	CDHR5_ENST00000349570.7_Missense_Mutation_p.P209L|CDHR5_ENST00000397542.2_Missense_Mutation_p.P209L			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	209	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						ATTCTCCCCCGGAGTGTCCTG	0.682													20	43					0	0	1	0	0	A	621243	G	A	621243	3	1	10	1	0	0	0	0	1	0	0	0	3144	1116	39	1	1947	1	CDHR5	11	621243	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08		621243	134385273	71	673										
OR56B4	196335	broad.mit.edu	37	chr11	6129437	6129437	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cagtacccctccatagtcacTaaagcttttgtcttcaaagc	5	13	3	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr11:6129437T>G	ENST00000316529.3	+	1	524	c.429T>G	c.(427-429)acT>acG	p.T143T	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCATAGTCACTAAAGCTTTTG	0.498													26	58					0	0	1	0	0	G	6129437	T	G	6129437	2	3	10	1	0	0	0	0	0	0	0	1	11184	1509	53	4		4	OR56B4	11	6129437	Silent	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	5508194	6129437	128877079	72	674										
MICALCL	84953	broad.mit.edu	37	chr11	12315221	12315221	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cccagggaaattcccctgtaTctgcctcatcacccaaagcc	6	17	3	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr11:12315221T>G	ENST00000256186.2	+	3	534	c.243T>G	c.(241-243)taT>taG	p.Y81*		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	81	Interaction with MAPK1 (By similarity).				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		TTCCCCTGTATCTGCCTCATC	0.587													6	189					0	0	1	0	0	G	12315221	T	G	12315221	4	3	10	1	0	0	0	0	0	1	0	0	9619	1442	50	4	249	4	MICALCL	11	12315221	Nonsense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	6185784	12315221	122691295	73	675										
MYBPC3	4607	broad.mit.edu	37	chr11	47360082	47360082	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cggcctcaccgatgaccttgActgtgaggttgacctggtcc	12	13	1	4			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr11:47360082A>T	ENST00000545968.1	-	23	2351	c.2297T>A	c.(2296-2298)gTc>gAc	p.V766D	MYBPC3_ENST00000256993.4_Missense_Mutation_p.V765D|MYBPC3_ENST00000399249.2_Missense_Mutation_p.V766D	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	765	Ig-like C2-type 5.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GATGACCTTGACTGTGAGGTT	0.617													9	64					0	0	1	0	0	T	47360082	A	T	47360082	3	4	10	1	0	0	0	0	1	0	0	0	10060	275	10	4	1575	4	MYBPC3	11	47360082	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	35044861	47360082	87646434	74	676										
MAP4K2	5871	broad.mit.edu	37	chr11	64563758	64563758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccctgacctggggatgatgcGctgggtgaggcggttggtgg	20	8	0	3	rs148240107		TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr11:64563758G>A	ENST00000294066.2	-	24	1829	c.1738C>T	c.(1738-1740)Cgc>Tgc	p.R580C	MAP4K2_ENST00000377350.3_Missense_Mutation_p.R572C	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	580	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						GGGATGATGCGCTGGGTGAGG	0.647													19	75					0	0	1	0	0	A	64563758	G	A	64563758	3	1	10	1	0	0	0	0	1	0	0	0	9309	1087	38	1	760	1	MAP4K2	11	64563758	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	17203676	64563758	70442758	75	677										
MCAM	4162	broad.mit.edu	37	chr11	119182524	119182524	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	agggagggcctcaccaaaaaTggccacgttgaccagctgtg	13	11	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr11:119182524T>G	ENST00000392814.1	-	5	1855	c.1126A>C	c.(1126-1128)Att>Ctt	p.I376L	MCAM_ENST00000264036.4_Missense_Mutation_p.I427L			P43121	MUC18_HUMAN	melanoma cell adhesion molecule	427	Ig-like C2-type 2.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		TCACCAAAAATGGCCACGTTG	0.602													70	5					0	0	1	0	0	G	119182524	T	G	119182524	3	3	10	1	0	0	0	0	1	0	0	0	9417	1464	51	4	689	4	MCAM	11	119182524	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	54618766	119182524	15823992	76	678										
ANO2	57101	broad.mit.edu	37	chr12	5941713	5941713	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tgcaggtgcgagctcagcttCtgcagagccgcgctgaactt	13	12	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr12:5941713C>G	ENST00000327087.8	-	5	749	c.678G>C	c.(676-678)caG>caC	p.Q226H	ANO2_ENST00000546188.1_Missense_Mutation_p.Q227H|ANO2_ENST00000356134.5_Missense_Mutation_p.Q227H			Q9NQ90	ANO2_HUMAN	anoctamin 2	231						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						AGCTCAGCTTCTGCAGAGCCG	0.522													14	36					0	0	1	0	0	G	5941713	C	G	5941713	3	3	10	1	0	0	0	0	1	0	0	0	691	912	32	2	2406	2	ANO2	12	5941713	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		5941713	127910182	77	679										
CHD4	1108	broad.mit.edu	37	chr12	6692406	6692406	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	attgtagttgacctgtttacGgattctttttcctttgccca	7	9	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr12:6692406G>A	ENST00000309577.6	-	26	4181	c.4018C>T	c.(4018-4020)Cgt>Tgt	p.R1340C	CHD4_ENST00000544484.1_Missense_Mutation_p.R1337C|CHD4_ENST00000544040.1_Missense_Mutation_p.R1333C|CHD4_ENST00000540960.1_5'UTR|RP5-940J5.6_ENST00000501075.2_RNA|CHD4_ENST00000357008.2_Missense_Mutation_p.R1340C			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1340					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ACCTGTTTACGGATTCTTTTT	0.562													69	107					0	0	1	0	0	A	6692406	G	A	6692406	3	1	10	1	0	0	0	0	1	0	0	0	3349	1116	39	1	1780	1	CHD4	12	6692406	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	750693	6692406	127159489	78	680										
FAM186B	84070	broad.mit.edu	37	chr12	49999203	49999203	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ctgggcagcctcaatcctcaGgatgatggctttcactgatg	11	11	3	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr12:49999203G>A	ENST00000257894.2	-	1	219	c.58C>T	c.(58-60)Ctg>Ttg	p.L20L	FAM186B_ENST00000551047.1_Silent_p.L20L|FAM186B_ENST00000544141.1_5'UTR	NM_032130.2	NP_115506.1	Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	20						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TCAATCCTCAGGATGATGGCT	0.517													10	22					0	0	1	0	0	A	49999203	G	A	49999203	2	1	10	1	0	0	0	0	0	0	0	1	5542	991	35	3		3	FAM186B	12	49999203	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	43306797	49999203	83852692	79	681										
EIF4B	1975	broad.mit.edu	37	chr12	53433961	53433961	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aagcaagtatgctgctctctCtgttgatggtgaagatgaaa	11	6	2	4			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr12:53433961C>G	ENST00000262056.9	+	15	2116	c.1790C>G	c.(1789-1791)tCt>tGt	p.S597C	RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000416762.3_Missense_Mutation_p.S558C|EIF4B_ENST00000420463.3_Missense_Mutation_p.S602C|RP11-983P16.4_ENST00000550601.1_RNA|RP11-983P16.4_ENST00000546566.1_RNA	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	597					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						GCTGCTCTCTCTGTTGATGGT	0.438													24	65					0	0	1	0	0	G	53433961	C	G	53433961	3	3	10	1	0	0	0	0	1	0	0	0	5055	913	32	2	1848	2	EIF4B	12	53433961	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	3434758	53433961	80417934	80	682										
CNPY2	10330	broad.mit.edu	37	chr12	56705098	56705098	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ctacacgtacgtagttcttgCgatgggtggaaggatcaatc	12	8	2	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr12:56705098C>T	ENST00000273308.4	-	4	845	c.305G>A	c.(304-306)cGc>cAc	p.R102H	RP11-977G19.11_ENST00000549860.1_RNA|RP11-977G19.11_ENST00000549565.1_RNA|RP11-977G19.10_ENST00000549318.1_Missense_Mutation_p.R102H	NM_014255.5	NP_055070.1	Q9Y2B0	CNPY2_HUMAN	canopy FGF signaling regulator 2	102	Saposin B-type.					endoplasmic reticulum|integral to plasma membrane	protein binding			large_intestine(2)|lung(2)	4						GTAGTTCTTGCGATGGGTGGA	0.532													115	111					0	0	1	0	0	T	56705098	C	T	56705098	3	4	10	1	0	0	0	0	1	0	0	0	3651	768	27	1	255	1	CNPY2	12	56705098	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	3271137	56705098	77146797	81	683										
TRHDE	29953	broad.mit.edu	37	chr12	72956730	72956730	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tatcaccatcttgggaaacaCaacagcagaaaatagaataa	6	8	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr12:72956730C>G	ENST00000261180.4	+	9	1913	c.1817C>G	c.(1816-1818)aCa>aGa	p.T606R	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	606					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTGGGAAACACAACAGCAGAA	0.328													32	35					0	0	1	0	0	G	72956730	C	G	72956730	3	3	10	1	0	0	0	0	1	0	0	0	16539	478	17	5	1851	5	TRHDE	12	72956730	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	16251632	72956730	60895165	82	684										
RYR3	6263	broad.mit.edu	37	chr15	34018592	34018592	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aaccctatcttccagctcatCcagacaggaaagggggaagc	10	12	2	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr15:34018592C>A	ENST00000389232.4	+	46	6988	c.6918C>A	c.(6916-6918)atC>atA	p.I2306I	RYR3_ENST00000415757.3_Silent_p.I2306I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2306	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCAGCTCATCCAGACAGGAA	0.547													6	6					8.12818e-05	8.79625e-05	1	1	0	A	34018592	C	A	34018592	2	1	10	1	0	0	0	0	0	0	0	1	13821	845	30	2		2	RYR3	15	34018592	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		34018592	68512800	83	685										
GOLGA6B	55889	broad.mit.edu	37	chr15	72954797	72954797	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gatgctccgagagcaggaggTgcagagagtgcgggagcagg	20	7	0	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr15:72954797T>C	ENST00000421285.3	+	11	1052	c.1052T>C	c.(1051-1053)gTg>gCg	p.V351A		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	351								p.V351A(4)		NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						GAGCAGGAGGTGCAGAGAGTG	0.562													3	7					0	0	1	0	0	C	72954797	T	C	72954797	3	2	10	1	0	0	0	0	1	0	0	0	6599	1696	59	4	1094	4	GOLGA6B	15	72954797	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	38936205	72954797	29576595	84	686										
NR2F2	7026	broad.mit.edu	37	chr15	96880650	96880650	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cagtgtgctttggaagaataCgttaggagccagtaccccaa	11	9	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr15:96880650C>T	ENST00000394166.3	+	3	2433	c.1044C>T	c.(1042-1044)taC>taT	p.Y348Y	NR2F2_ENST00000421109.2_Silent_p.Y215Y|NR2F2_ENST00000394171.2_Silent_p.Y195Y|NR2F2_ENST00000453270.2_Silent_p.Y195Y	NM_021005.3	NP_066285.1	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	348	Important for dimerization.|Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(2)|lung(3)|ovary(2)|urinary_tract(1)	17	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			TGGAAGAATACGTTAGGAGCC	0.493													100	42					0	0	1	0	0	T	96880650	C	T	96880650	2	4	10	1	0	0	0	0	0	0	0	1	10675	547	19	1		1	NR2F2	15	96880650	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	23925853	96880650	5650742	85	687										
NOD2	64127	broad.mit.edu	37	chr16	50745263	50745263	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aagagacctcagccctgcacGgtttgtgccacctgcctgtc	10	15	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr16:50745263G>C	ENST00000300589.2	+	4	1546	c.1441G>C	c.(1441-1443)Ggt>Cgt	p.G481R		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	481	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGCCCTGCACGGTTTGTGCCA	0.597													41	65					0	0	1	0	0	C	50745263	G	C	50745263	3	2	10	1	0	0	0	0	1	0	0	0	10563	1116	39	5	1455	5	NOD2	16	50745263	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08		50745263	39609490	86	688										
SF3B3	23450	broad.mit.edu	37	chr16	70575650	70575650	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gccatgcctctggaagaaggAgacacattcttttttcagcc	9	11	3	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr16:70575650A>G	ENST00000302516.5	+	9	1357	c.1146A>G	c.(1144-1146)ggA>ggG	p.G382G		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	382					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				TGGAAGAAGGAGACACATTCT	0.448													4	109					0	0	1	0	0	G	70575650	A	G	70575650	2	3	10	1	0	0	0	0	0	0	0	1	14205	291	11	4		4	SF3B3	16	70575650	Silent	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	19830387	70575650	19779103	87	689										
ASGR2	433	broad.mit.edu	37	chr17	7011223	7011223	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tgatcttgtcacccacgctgCctcctggaagcggaaagcca	10	14	2	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr17:7011223C>T	ENST00000380952.2	-	5	620	c.356G>A	c.(355-357)gGc>gAc	p.G119D	ASGR2_ENST00000446679.2_Missense_Mutation_p.G100D|ASGR2_ENST00000254850.7_Missense_Mutation_p.G95D|ASGR2_ENST00000355035.5_Missense_Mutation_p.G119D	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	119					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	ACCCACGCTGCCTCCTGGAAG	0.647													27	1					0	0	1	0	0	T	7011223	C	T	7011223	3	4	10	1	0	0	0	0	1	0	0	0	1039	739	26	3	599	3	ASGR2	17	7011223	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		7011223	74183987	88	690										
TP53	7157	broad.mit.edu	37	chr17	7577559	7577559	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggttcatgccgcccatgcagGaactgttacacatgtagttg	11	10	1	0	rs28934573		TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr17:7577559G>T	ENST00000420246.2	-	7	854	c.722C>A	c.(721-723)tCc>tAc	p.S241Y	TP53_ENST00000445888.2_Missense_Mutation_p.S241Y|TP53_ENST00000413465.2_Missense_Mutation_p.S241Y|TP53_ENST00000455263.2_Missense_Mutation_p.S241Y|TP53_ENST00000269305.4_Missense_Mutation_p.S241Y|TP53_ENST00000359597.4_Missense_Mutation_p.S241Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			37	4					0.000228196	0.000241979	1	1	0	T	7577559	G	T	7577559	3	4	10	1	0	0	0	0	1	0	0	0	16441	1174	41	2	568	2	TP53	17	7577559	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	566336	7577559	73617651	89	691										
MYH1	4619	broad.mit.edu	37	chr17	10404746	10404746	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gctcccgggagagatcagagCgctgcttctctgctttggcc	13	13	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr17:10404746C>T	ENST00000226207.5	-	27	3513	c.3419G>A	c.(3418-3420)cGc>cAc	p.R1140H	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1140						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.R1140H(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GAGATCAGAGCGCTGCTTCTC	0.587													52	9					0	0	1	0	0	T	10404746	C	T	10404746	3	4	10	1	0	0	0	0	1	0	0	0	10076	768	27	1	2456	1	MYH1	17	10404746	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	2827187	10404746	70790464	90	692										
DHRS7B	25979	broad.mit.edu	37	chr17	21075510	21075510	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cacctcagggctgggcaaagGtgggtcctggaggcagtgct	17	10	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr17:21075510G>T	ENST00000395511.3	+	2	519		c.e2+1		DHRS7B_ENST00000579303.1_Splice_Site	NM_015510.4	NP_056325.2	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B							integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|pancreas(2)	7						CTGGGCAAAGGTGGGTCCTGG	0.677													16	0					6.94344e-10	8.1264e-10	1	1	0	T	21075510	G	T	21075510	5	4	10	1	0	0	0	0	0	0	1	0	4524	1275	44	5	206	5	DHRS7B	17	21075510	Splice_Site	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	10670764	21075510	60119700	91	693										
NPEPPS	9520	broad.mit.edu	37	chr17	45689855	45689855	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	atgcactcctgaggggcttgGttctgggaaaactaggaaaa	13	7	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr17:45689855G>T	ENST00000322157.4	+	18	2362	c.2125G>T	c.(2125-2127)Gtt>Ttt	p.V709F	RP11-580I16.2_ENST00000582066.1_RNA|NPEPPS_ENST00000530173.1_Missense_Mutation_p.V705F|RP11-580I16.2_ENST00000582389.1_RNA|NPEPPS_ENST00000544660.1_Missense_Mutation_p.V629F	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	709					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						GAGGGGCTTGGTTCTGGGAAA	0.428													13	18					4.3838e-07	4.98303e-07	1	1	0	T	45689855	G	T	45689855	3	4	10	1	0	0	0	0	1	0	0	0	10621	1261	44	5	2195	5	NPEPPS	17	45689855	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	24614345	45689855	35505355	92	694										
ANKFN1	162282	broad.mit.edu	37	chr17	54558122	54558122	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cccatgcaattgttcttctaCgagctccagatggcagtgaa	9	11	2	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr17:54558122C>G	ENST00000566473.2	+	16	2043	c.2043C>G	c.(2041-2043)taC>taG	p.Y681*	ANKFN1_ENST00000318698.2_Nonsense_Mutation_p.Y681*			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	681										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						TGTTCTTCTACGAGCTCCAGA	0.418													36	71					0	0	1	0	0	G	54558122	C	G	54558122	4	3	10	1	0	0	0	0	0	1	0	0	621	547	19	5	2105	5	ANKFN1	17	54558122	Nonsense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	8868267	54558122	26637088	93	695										
MBP	4155	broad.mit.edu	37	chr18	74700335	74700335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	agctgtgggcagagaggtctCgagaggagagaaaaggaggc	19	5	1	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr18:74700335C>T	ENST00000397869.3	-	4	513	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	MBP_ENST00000527041.1_Intron|MBP_ENST00000359645.3_Intron|MBP_ENST00000397866.4_Intron|MBP_ENST00000526111.1_Intron|MBP_ENST00000580402.1_Intron|MBP_ENST00000354542.4_Intron|MBP_ENST00000528160.1_Intron|MBP_ENST00000382582.3_Intron|MBP_ENST00000579129.1_Intron|MBP_ENST00000397875.3_Intron|MBP_ENST00000578193.1_Intron|MBP_ENST00000355994.2_Intron|MBP_ENST00000397865.5_Intron			P02686	MBP_HUMAN	myelin basic protein	218					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		AGAGAGGTCTCGAGAGGAGAG	0.567													6	10					0	0	1	0	0	T	74700335	C	T	74700335	3	4	10	1	0	0	0	0	1	0	0	0	9408	899	31	1		1	MBP	18	74700335	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		74700335	3376913	94	696										
MUC16	94025	broad.mit.edu	37	chr19	9058814	9058814	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gtgaccactggagatatcacTtttgttggctctgagaagcc	11	9	2	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:9058814T>A	ENST00000397910.4	-	3	28835	c.28632A>T	c.(28630-28632)aaA>aaT	p.K9544N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9546	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGATATCACTTTTGTTGGCT	0.458													20	19					0	0	1	0	0	A	9058814	T	A	9058814	3	1	10	1	0	0	0	0	1	0	0	0	10020	1606	56	4	15219	4	MUC16	19	9058814	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08		9058814	50070169	95	697										
HPN	3249	broad.mit.edu	37	chr19	35540200	35540200	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ggtgtctgttgcaggtggccGgactgtgccatgctgctcca	15	11	1	0	rs149970077	byFrequency	TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:35540200G>A	ENST00000262626.2	+	3	848	c.23G>A	c.(22-24)cGg>cAg	p.R8Q	HPN_ENST00000392226.1_Missense_Mutation_p.R8Q|HPN_ENST00000597419.1_Intron	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	8					cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GCAGGTGGCCGGACTGTGCCA	0.672													31	216					0	0	1	0	0	A	35540200	G	A	35540200	3	1	10	1	0	0	0	0	1	0	0	0	7376	1116	39	1	29	1	HPN	19	35540200	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	26481386	35540200	23588783	96	698										
ZFP36	7538	broad.mit.edu	37	chr19	39898948	39898950	+	In_Frame_Del	DEL	CAC	CAC	-													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gccctctggccgccggacctCaccaccaccaccaggcctgg							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:39898948_39898950delCAC	ENST00000597629.1	+	2	682_684	c.608_610delCAC	c.(607-612)tca>t	p.SP203del	ZFP36_ENST00000248673.3_In_Frame_Del_p.SP197del			P26651	TTP_HUMAN	ZFP36 ring finger protein	197					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGCCGGACCTCACCACCACCACC	0.685													10	1302	---	---	---	---						-	39898950	CAC	-	39898948	7	5	10	1	0	1	0	1	0	0	0	0	17702	838	29	0	596	0	ZFP36	19	39898948	In_Frame_Del	DEL	CAC	TCGA-N5-A4RT-01A-11D-A28R-08	4358748	39898948	19230035	97	699										
CYP2S1	29785	broad.mit.edu	37	chr19	41707232	41707232	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cgatgacggtcagcaccacgGtcggctataccctcctgctc	10	16	1	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:41707232G>T	ENST00000310054.4	+	6	1147	c.931G>T	c.(931-933)Gtc>Ttc	p.V311F	CYP2S1_ENST00000542619.1_Missense_Mutation_p.V36F	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	311					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						CAGCACCACGGTCGGCTATAC	0.498													36	87					1.08052e-11	1.27405e-11	1	1	0	T	41707232	G	T	41707232	3	4	10	1	0	0	0	0	1	0	0	0	4197	1261	44	5	953	5	CYP2S1	19	41707232	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	1808284	41707232	17421751	98	700										
ZNF234	10780	broad.mit.edu	37	chr19	44660704	44660704	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gagagaagtctcatacatgtGatgagtgtggaaaaagcttc	12	5	1	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:44660704G>A	ENST00000426739.2	+	6	793	c.535G>A	c.(535-537)Gat>Aat	p.D179N	ZNF234_ENST00000592437.1_Missense_Mutation_p.D179N	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				TCATACATGTGATGAGTGTGG	0.388													35	78					0	0	1	0	0	A	44660704	G	A	44660704	3	1	10	1	0	0	0	0	1	0	0	0	17844	1290	45	3	549	3	ZNF234	19	44660704	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	2953472	44660704	14468279	99	701										
RASIP1	54922	broad.mit.edu	37	chr19	49228098	49228098	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tccaaggctgcctggaacacGcccagggtaggtctcaatcc	11	14	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:49228098G>A	ENST00000222145.4	-	9	2451	c.2247C>T	c.(2245-2247)ggC>ggT	p.G749G		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	749	Dilute.				signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CCTGGAACACGCCCAGGGTAG	0.612													38	87					0	0	1	0	0	A	49228098	G	A	49228098	2	1	10	1	0	0	0	0	0	0	0	1	13129	1074	38	1		1	RASIP1	19	49228098	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	4567394	49228098	9900885	100	702										
CCDC155	147872	broad.mit.edu	37	chr19	49920659	49920659	+	Frame_Shift_Del	DEL	C	C	-													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccactgatcccagctcctgtCctgggcctgctgctgctgct							TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr19:49920659delC	ENST00000447857.3	+	20	1786	c.1581delC	c.(1579-1581)gtfs	p.V527fs		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	527						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						CAGCTCCTGTCCTGGGCctgc	0.652													2	4	---	---	---	---						-	49920659	C	-	49920659	7	5	10	1	0	1	0	1	0	0	0	0	2807	842	30	0	1655	0	CCDC155	19	49920659	Frame_Shift_Del	DEL	C	TCGA-N5-A4RT-01A-11D-A28R-08	692561	49920659	9208324	101	703										
BAGE2	85319	broad.mit.edu	37	chr21	11068846	11068846	+	RNA	DEL	G	G	-													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	taatcttttagaatgatgctGgaactgccaaataattcata					rs140512265		TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr21:11068846delG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gaatgatgctggaactgccaa	0.289													2	4	---	---	---	---						-	11068846	G	-	11068846	6	5	10	0	1	1	0	1	0	0	0	0	1290	1363	47	0		0	BAGE2	21	11068846	RNA	DEL	G	TCGA-N5-A4RT-01A-11D-A28R-08		11068846	37061049	102	704										
BAGE2	85319	broad.mit.edu	37	chr21	11082601	11082603	+	RNA	DEL	CTC	CTC	-													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tttaggaacaaagttgtcttCtccttctgacactgttctca					rs150832397		TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr21:11082601_11082603delCTC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGTTGTCTTCTCCTTCTGACAC	0.32													2	4	---	---	---	---						-	11082603	CTC	-	11082601	6	5	10	0	1	1	0	1	0	0	0	0	1290	928	32	0		0	BAGE2	21	11082601	RNA	DEL	CTC	TCGA-N5-A4RT-01A-11D-A28R-08	13755	11082601	37047294	103	705										
BAGE2	85319	broad.mit.edu	37	chr21	11088890	11088891	+	RNA	INS	-	-	A													0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aaacatctggaaaaatatacINSaaaaaaagtttccagtgata					rs143023296		TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr21:11088890_11088891insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAAAATATACAAAAAAAGTTT	0.292													4	6	---	---	---	---						A	11088891	-	A	11088890	6	5	10	0	1	1	1	0	0	0	0	0	1290	493	17	0		0	BAGE2	21	11088890	RNA	INS	-	TCGA-N5-A4RT-01A-11D-A28R-08	6289	11088890	37041005	104	706										
TIAM1	7074	broad.mit.edu	37	chr21	32513671	32513671	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tggtagtgctcctcgctctcCgcatcggtcagggcgaacag	13	13	2	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr21:32513671C>T	ENST00000286827.3	-	22	4098	c.3627G>A	c.(3625-3627)gcG>gcA	p.A1209A	TIAM1_ENST00000541036.1_Silent_p.A1149A	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1209	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity	p.A1209A(2)		autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CCTCGCTCTCCGCATCGGTCA	0.597													35	98					0	0	1	0	0	T	32513671	C	T	32513671	2	4	10	1	0	0	0	0	0	0	0	1	15949	639	23	1		1	TIAM1	21	32513671	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	21424781	32513671	15616224	105	707										
SIK1	150094	broad.mit.edu	37	chr21	44840174	44840174	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	atacccagcgcctgctcatcGtagtcgcccaggttggaggt	12	13	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr21:44840174G>A	ENST00000270162.6	-	8	1044	c.912C>T	c.(910-912)taC>taT	p.Y304Y		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	304	UBA.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						CCTGCTCATCGTAGTCGCCCA	0.692													42	32					0	0	1	0	0	A	44840174	G	A	44840174	2	1	10	1	0	0	0	0	0	0	0	1	14371	1140	40	1		1	SIK1	21	44840174	Silent	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	12326503	44840174	3289721	106	708										
PKDREJ	10343	broad.mit.edu	37	chr22	46657752	46657752	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	caaaattgaccatttatagaAatcacggcttgcacaatttg	6	8	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr22:46657752A>C	ENST00000253255.5	-	1	1467	c.1468T>G	c.(1468-1470)Ttc>Gtc	p.F490V		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	490	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CATTTATAGAAATCACGGCTT	0.368													51	57					0	0	1	0	0	C	46657752	A	C	46657752	3	2	10	1	0	0	0	0	1	0	0	0	12017	14	1	4	5297	4	PKDREJ	22	46657752	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08		46657752	4646814	107	709										
CELSR1	9620	broad.mit.edu	37	chr22	46804949	46804949	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ctccatcagaacgctgtcctCcttccgggtccggaacatga	9	15	1	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr22:46804949C>G	ENST00000262738.3	-	9	5169	c.5170G>C	c.(5170-5172)Gag>Cag	p.E1724Q		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1724	Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACGCTGTCCTCCTTCCGGGTC	0.642													46	3					0	0	1	0	0	G	46804949	C	G	46804949	3	3	10	1	0	0	0	0	1	0	0	0	3243	864	30	2	3982	2	CELSR1	22	46804949	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	147197	46804949	4499617	108	710										
HDAC10	83933	broad.mit.edu	37	chr22	50686488	50686488	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	gctcggtgcagatgcagctgCcttacacactggacccccag	11	15	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chr22:50686488C>A	ENST00000216271.5	-	13	1520	c.1168G>T	c.(1168-1170)Gca>Tca	p.A390S	HDAC10_ENST00000498366.1_5'UTR|MAPK12_ENST00000497036.1_5'UTR|HDAC10_ENST00000448072.1_Missense_Mutation_p.A340S|HDAC10_ENST00000349505.4_Missense_Mutation_p.A370S	NM_001159286.1|NM_032019.5	NP_001152758.1|NP_114408.3	Q969S8	HDA10_HUMAN	histone deacetylase 10	390					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)			endometrium(2)|kidney(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GATGCAGCTGCCTTACACACT	0.652													6	58					3.59834e-05	3.94817e-05	1	1	0	A	50686488	C	A	50686488	3	1	10	1	0	0	0	0	1	0	0	0	7045	739	26	5	873	5	HDAC10	22	50686488	Missense_Mutation	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	3881539	50686488	618078	109	711										
PLCXD1	55344	broad.mit.edu	37	chrX	215882	215882	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ccgcggctgagcgcgtgggtCcgagagcagtgcccggggcc	19	14	0	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:215882C>T	ENST00000381657.2	+	7	1366	c.852C>T	c.(850-852)gtC>gtT	p.V284V	PLCXD1_ENST00000399012.1_Silent_p.V284V|PLCXD1_ENST00000381663.3_Silent_p.V284V	NM_018390.3	NP_060860.1	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 1	284					intracellular signal transduction|lipid metabolic process		phospholipase C activity			endometrium(3)|large_intestine(1)|lung(7)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCGCGTGGGTCCGAGAGCAGT	0.647													9	74					0	0	1	0	0	T	215882	C	T	215882	2	4	10	1	0	0	0	0	0	0	0	1	12088	842	30	3		3	PLCXD1	23	215882	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08		215882	155054678	110	712										
AP1S2	8905	broad.mit.edu	37	chrX	15864064	15864064	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aagtaattccacataacgatGaattatttccagggtaatta	6	6	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:15864064G>T	ENST00000380291.1	-	3	366	c.250C>A	c.(250-252)Cat>Aat	p.H84N	AP1S2_ENST00000421527.2_Missense_Mutation_p.H126N|AP1S2_ENST00000329235.2_Missense_Mutation_p.H84N|AP1S2_ENST00000545766.1_Missense_Mutation_p.H126N			P56377	AP1S2_HUMAN	adaptor-related protein complex 1, sigma 2 subunit	84					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	AP-type membrane coat adaptor complex|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein transporter activity			large_intestine(1)	1	Hepatocellular(33;0.183)					ACATAACGATGAATTATTTCC	0.318													37	65					4.32679e-17	5.34088e-17	1	1	0	T	15864064	G	T	15864064	3	4	10	1	0	0	0	0	1	0	0	0	733	1290	45	2	235	2	AP1S2	23	15864064	Missense_Mutation	SNP	G	TCGA-N5-A4RT-01A-11D-A28R-08	15648182	15864064	139406496	111	713										
WDR45	11152	broad.mit.edu	37	chrX	48933595	48933595	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	tctccaggctggggcagaggTcacagagccctagggtgtga	16	10	2	3			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:48933595T>A	ENST00000356463.3	-	8	887	c.449A>T	c.(448-450)gAc>gTc	p.D150V	WDR45_ENST00000376358.3_Missense_Mutation_p.D47V|WDR45_ENST00000376372.3_Missense_Mutation_p.D149V|WDR45_ENST00000396681.4_Missense_Mutation_p.D149V|WDR45_ENST00000473974.1_Missense_Mutation_p.D149V|WDR45_ENST00000485908.1_Missense_Mutation_p.D114V|WDR45_ENST00000322995.8_Missense_Mutation_p.D160V|WDR45_ENST00000553851.1_Missense_Mutation_p.D47V|WDR45_ENST00000376368.2_Missense_Mutation_p.D150V|WDR45_ENST00000470270.1_5'UTR	NM_007075.3	NP_009006.2	Q9Y484	WIPI4_HUMAN	WD repeat domain 45	149					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	19						GGGGCAGAGGTCACAGAGCCC	0.597													8	25					0	0	1	0	0	A	48933595	T	A	48933595	3	1	10	1	0	0	0	0	1	0	0	0	17356	1667	58	4	656	4	WDR45	23	48933595	Missense_Mutation	SNP	T	TCGA-N5-A4RT-01A-11D-A28R-08	33069531	48933595	106336965	112	714										
GSPT2	23708	broad.mit.edu	37	chrX	51487066	51487066	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	acctgtggaaccttcccgagAggaaccgttagtgtcgcttg	12	11	0	1			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:51487066A>G	ENST00000340438.4	+	1	586	c.344A>G	c.(343-345)gAg>gGg	p.E115G		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	115					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					CCTTCCCGAGAGGAACCGTTA	0.557													5	22					0	0	1	0	0	G	51487066	A	G	51487066	3	3	10	1	0	0	0	0	1	0	0	0	6867	304	11	4	346	4	GSPT2	23	51487066	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	2553471	51487066	103783494	113	715										
MED12	9968	broad.mit.edu	37	chrX	70350051	70350051	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cccccagcggcagcgcataaAgcgcattctccaggtaggcc	11	16	1	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:70350051A>C	ENST00000333646.6	+	28	4233	c.4034A>C	c.(4033-4035)aAg>aCg	p.K1345T	MED12_ENST00000374080.3_Missense_Mutation_p.K1345T|MED12_ENST00000478889.1_Intron|MED12_ENST00000374102.1_Missense_Mutation_p.K1345T	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1345					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CAGCGCATAAAGCGCATTCTC	0.577			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						6	25					0	0	1	0	0	C	70350051	A	C	70350051	3	2	10	1	0	0	0	0	1	0	0	0	9477	72	3	4	4144	4	MED12	23	70350051	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	18862985	70350051	84920509	114	716										
MED12	9968	broad.mit.edu	37	chrX	70356869	70356869	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	ctgtacacccagaaccagccActacctgcaggtgagtgcca	9	15	0	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:70356869A>G	ENST00000333646.6	+	38	5740	c.5541A>G	c.(5539-5541)ccA>ccG	p.P1847P	MED12_ENST00000374080.3_Silent_p.P1847P|MED12_ENST00000478889.1_3'UTR|MED12_ENST00000374102.1_Silent_p.P1847P	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1847	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					AGAACCAGCCACTACCTGCAG	0.567			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						9	12					0	0	1	0	0	G	70356869	A	G	70356869	2	3	10	1	0	0	0	0	0	0	0	1	9477	146	6	4		4	MED12	23	70356869	Silent	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	6818	70356869	84913691	115	717										
CHM	1121	broad.mit.edu	37	chrX	85211373	85211373	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	aaatattcataaaatgtgatCtcttcatatcctatgaaaag	4	6	3	2			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:85211373C>T	ENST00000357749.2	-	8	980	c.951G>A	c.(949-951)gaG>gaA	p.E317E	CHM_ENST00000537751.1_Silent_p.E169E|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	317					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				AAAATGTGATCTCTTCATATC	0.328													6	21					0	0	1	0	0	T	85211373	C	T	85211373	2	4	10	1	0	0	0	0	0	0	0	1	3372	912	32	3		3	CHM	23	85211373	Silent	SNP	C	TCGA-N5-A4RT-01A-11D-A28R-08	14854504	85211373	70059187	116	718										
MAMLD1	10046	broad.mit.edu	37	chrX	149639635	149639635	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0964912280701754	11	0.896252527262782	1.50922778047596	1.89470154258887	1.29044537495242	1	1	0	cactgccaccttgcagctgcAgcagcagcagcagcaacagc	10	16	0	0			TCGA-N5-A4RT-01A-11D-A28R-08	TCGA-N5-A4RT-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c5ba0fc-0d9e-4c86-9586-5455d7fb1d62	353669cd-e066-4c65-b425-957cf45bf674	g.chrX:149639635A>T	ENST00000370401.2	+	4	2100	c.1790A>T	c.(1789-1791)cAg>cTg	p.Q597L	MAMLD1_ENST00000455522.2_Missense_Mutation_p.Q78L|MAMLD1_ENST00000262858.5_Missense_Mutation_p.Q597L|MAMLD1_ENST00000426613.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000432680.2_Missense_Mutation_p.Q572L			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	597	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					TTgcagctgcagcagcagcag	0.607													5	102					0	0	1	0	0	T	149639635	A	T	149639635	3	4	10	1	0	0	0	0	1	0	0	0	9257	188	7	4	1800	4	MAMLD1	23	149639635	Missense_Mutation	SNP	A	TCGA-N5-A4RT-01A-11D-A28R-08	64428262	149639635	5630925	117	719										
CDK11B	984	broad.mit.edu	37	chr1	1580603	1580603	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gctcccgctcccgcttccttTctaactgctccaagcggtcc	7	19	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr1:1580603T>C	ENST00000407249.3	-	7	523	c.524A>G	c.(523-525)gAa>gGa	p.E175G	CDK11B_ENST00000317673.7_Missense_Mutation_p.E173G|CDK11B_ENST00000340677.5_Missense_Mutation_p.E162G|CDK11B_ENST00000341832.6_Missense_Mutation_p.E128G			P21127	CD11B_HUMAN	cyclin-dependent kinase 11B	172	Glu-rich.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			endometrium(2)|large_intestine(3)|lung(4)|skin(1)|stomach(2)	12						CCGCTTCCTTTCTAACTGCTC	0.602													5	43					0	0	1	0	0	C	1580603	T	C	1580603	3	2	11	1	0	0	0	0	1	0	0	0	3149	1798	62	4		4	CDK11B	1	1580603	Missense_Mutation	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08		1580603	247670018	1	720										
AJAP1	55966	broad.mit.edu	37	chr1	4772161	4772161	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ccagcgcgggtcccggccccGgtgtggagcccccggccgcc	16	20	0	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr1:4772161G>T	ENST00000378191.4	+	2	612	c.231G>T	c.(229-231)ccG>ccT	p.P77P	AJAP1_ENST00000378190.3_Silent_p.P77P|AJAP1_ENST00000466761.1_3'UTR	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	77					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TCCCGGCCCCGGTGTGGAGCC	0.776													5	30					1	1	1	1	0	T	4772161	G	T	4772161	2	4	11	1	0	0	0	0	0	0	0	1	435	1103	39	5		5	AJAP1	1	4772161	Silent	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	3191558	4772161	244478460	2	721										
FCRL1	115350	broad.mit.edu	37	chr1	157771352	157771352	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ctgaggtaagatgattgcttCtggccccagtaggcactaga	12	9	1	4			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr1:157771352C>T	ENST00000368176.3	-	6	969	c.902G>A	c.(901-903)aGa>aAa	p.R301K	FCRL1_ENST00000358292.3_Intron|FCRL1_ENST00000489998.1_Intron|FCRL1_ENST00000491942.1_Missense_Mutation_p.R301K	NM_001159398.1|NM_052938.4	NP_001152870.1|NP_443170.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	301						integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ATGATTGCTTCTGGCCCCAGT	0.532													12	52					0	0	1	0	0	T	157771352	C	T	157771352	3	4	11	1	0	0	0	0	1	0	0	0	5826	913	32	3	477	3	FCRL1	1	157771352	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	152999191	157771352	91479269	3	722										
PNPT1	87178	broad.mit.edu	37	chr2	55872564	55872564	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tctgtaatatctccttttttGccactagaagagaaaaacac	5	9	2	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:55872564G>A	ENST00000447944.2	-	22	1828	c.1742C>T	c.(1741-1743)gCa>gTa	p.A581V		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	581					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTCCTTTTTTGCCACTAGAAG	0.294													8	21					0	0	1	0	0	A	55872564	G	A	55872564	3	1	11	1	0	0	0	0	1	0	0	0	12220	1319	46	3	637	3	PNPT1	2	55872564	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		55872564	187326809	4	723										
UXS1	80146	broad.mit.edu	37	chr2	106761661	106761661	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ctcaccctcgatgtagagggGctccaccacgtcgtggttaa	11	13	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:106761661G>C	ENST00000283148.7	-	6	554	c.457C>G	c.(457-459)Ccc>Gcc	p.P153A	UXS1_ENST00000409501.3_Missense_Mutation_p.P148A|UXS1_ENST00000540130.1_Missense_Mutation_p.P91A|UXS1_ENST00000428048.2_Intron|UXS1_ENST00000479621.1_5'UTR	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	148					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						ATGTAGAGGGGCTCCACCACG	0.527													16	48					0	0	1	0	0	C	106761661	G	C	106761661	3	2	11	1	0	0	0	0	1	0	0	0	17168	1203	42	5	860	5	UXS1	2	106761661	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	50889097	106761661	136437712	5	724										
BCL2L11	10018	broad.mit.edu	37	chr2	111921771	111921772	+	Frame_Shift_Ins	INS	-	-	A													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	atggttatcttacgactgttINSacgttacattgtccgcctgg							TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:111921771_111921772insA	ENST00000393256.3	+	4	833_834	c.560_561insA	c.(559-561)tcgfs	p.S187fs	BCL2L11_ENST00000308659.8_Frame_Shift_Ins_p.S127fs	NM_001204106.1|NM_006538.4|NM_138621.4|NM_138627.3	NP_001191035.1|NP_006529.1|NP_619527.1|NP_619533.1	O43521	B2L11_HUMAN	BCL2-like 11 (apoptosis facilitator)	187					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(3)|lung(2)|prostate(2)	11						TTACGACTGTTACGTTACATTG	0.436													25	44	---	---	---	---						A	111921772	-	A	111921771	7	5	11	1	0	1	1	0	0	0	0	0	1367	1764	61	0	699	0	BCL2L11	2	111921771	Frame_Shift_Ins	INS	-	TCGA-N5-A4RU-01A-31D-A28R-08	5160110	111921771	131277602	6	725										
GALNT3	2591	broad.mit.edu	37	chr2	166615897	166615897	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gcttctcatgatcaggaagcGactcccagccaaatgaaaga	9	11	2	3			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:166615897G>C	ENST00000392701.3	-	5	1797	c.1022C>G	c.(1021-1023)tCg>tGg	p.S341W	GALNT3_ENST00000409882.1_Missense_Mutation_p.S79W	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	341					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						ATCAGGAAGCGACTCCCAGCC	0.388													4	26					0	0	1	0	0	C	166615897	G	C	166615897	3	2	11	1	0	0	0	0	1	0	0	0	6253	1059	37	2	907	2	GALNT3	2	166615897	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	54694126	166615897	76583476	7	726										
TTN	7273	broad.mit.edu	37	chr2	179635252	179635252	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	agtaaattgttcctttgacaGagatagcatacttttcattg	7	6	1	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:179635252G>C	ENST00000589042.1	-	35	8491	c.8267C>G	c.(8266-8268)tCt>tGt	p.S2756C	TTN_ENST00000460472.2_Missense_Mutation_p.S2710C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S2756C|TTN_ENST00000359218.5_Missense_Mutation_p.S2710C|TTN_ENST00000342992.6_Missense_Mutation_p.S2756C|TTN_ENST00000360870.5_Missense_Mutation_p.S2756C|TTN_ENST00000342175.6_Missense_Mutation_p.S2710C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2494							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTTGACAGAGATAGCATA	0.443													10	61					0	0	1	0	0	C	179635252	G	C	179635252	3	2	11	1	0	0	0	0	1	0	0	0	16796	942	33	2	103033	2	TTN	2	179635252	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	13019355	179635252	63564121	8	727										
ALS2CR11	151254	broad.mit.edu	37	chr2	202483678	202483678	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tgttcttaggcagggccgtcGtgccctggttcagggcgtaa	15	10	2	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:202483678G>T	ENST00000439140.1	-	1	220	c.176C>A	c.(175-177)aCg>aAg	p.T59K	ALS2CR11_ENST00000286195.3_Missense_Mutation_p.T59K|ALS2CR11_ENST00000439802.1_Missense_Mutation_p.T59K|ALS2CR11_ENST00000450242.1_Missense_Mutation_p.T59K	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	59										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						CAGGGCCGTCGTGCCCTGGTT	0.647													13	37					4.3838e-07	4.97744e-07	1	1	0	T	202483678	G	T	202483678	3	4	11	1	0	0	0	0	1	0	0	0	548	1145	40	5	5497	5	ALS2CR11	2	202483678	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	22848426	202483678	40715695	9	728										
SNED1	25992	broad.mit.edu	37	chr2	242021733	242021733	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cctgcacaaggctgttctccGagacaaaggcctttccagtc	9	14	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr2:242021733G>A	ENST00000310397.8	+	29	4075	c.4075G>A	c.(4075-4077)Gag>Aag	p.E1359K	SNED1_ENST00000405547.3_Missense_Mutation_p.E1326K|SNED1_ENST00000342631.6_Missense_Mutation_p.E1326K	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	1359					cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		GCTGTTCTCCGAGACAAAGGC	0.582													37	63					0	0	1	0	0	A	242021733	G	A	242021733	3	1	11	1	0	0	0	0	1	0	0	0	14898	1059	37	1	4189	1	SNED1	2	242021733	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	39538055	242021733	1177640	10	729										
CACNA2D3	55799	broad.mit.edu	37	chr3	55038789	55038789	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ccttccatttctttcctgtaGaattaccctttatgactacc	3	13	1	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr3:55038789G>C	ENST00000474759.1	+	32	2738		c.e32-1		CACNA2D3_ENST00000415676.2_Splice_Site|CACNA2D3_ENST00000288197.5_Splice_Site|CACNA2D3_ENST00000478261.1_Splice_Site|CACNA2D3_ENST00000490478.1_Splice_Site	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CTTTCCTGTAGAATTACCCTT	0.453													11	39					0	0	1	0	0	C	55038789	G	C	55038789	5	2	11	1	0	0	0	0	0	0	1	0	2568	956	33	2	2816	2	CACNA2D3	3	55038789	Splice_Site	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		55038789	142983641	11	730										
CCDC37	348807	broad.mit.edu	37	chr3	126132950	126132950	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	catggtcctgacccttcagcGaaccctttccacttatctgg	7	15	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr3:126132950G>A	ENST00000393425.1	+	4	252	c.153G>A	c.(151-153)gcG>gcA	p.A51A	CCDC37_ENST00000510833.1_Silent_p.A51A|CCDC37_ENST00000505024.1_Silent_p.A51A|CCDC37_ENST00000352312.1_Silent_p.A51A			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	51										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		ACCCTTCAGCGAACCCTTTCC	0.572													61	119					0	0	1	0	0	A	126132950	G	A	126132950	2	1	11	1	0	0	0	0	0	0	0	1	2828	1045	37	1		1	CCDC37	3	126132950	Silent	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	71094161	126132950	71889480	12	731										
KCNAB1	7881	broad.mit.edu	37	chr3	156181519	156181519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gtctggtcataacaaccaaaCtctactggggtggaaagtaa	10	8	3	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr3:156181519C>T	ENST00000302490.8	+	6	1328	c.457C>T	c.(457-459)Ctc>Ttc	p.L153F	KCNAB1_ENST00000389634.5_Missense_Mutation_p.L153F|KCNAB1_ENST00000389636.5_Missense_Mutation_p.L171F|KCNAB1_ENST00000497291.1_3'UTR|KCNAB1_ENST00000490337.1_Missense_Mutation_p.L171F|KCNAB1_ENST00000471742.1_Missense_Mutation_p.L160F	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	171						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AACAACCAAACTCTACTGGGG	0.338													8	29					0	0	1	0	0	T	156181519	C	T	156181519	3	4	11	1	0	0	0	0	1	0	0	0	8052	565	20	3	1004	3	KCNAB1	3	156181519	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	30048569	156181519	41840911	13	732										
KDR	3791	broad.mit.edu	37	chr4	55981195	55981195	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ttaccatcaggaacaaatctCttttctgggtatctctgggt	8	9	4	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr4:55981195C>A	ENST00000263923.4	-	5	799	c.504G>T	c.(502-504)aaG>aaT	p.K168N		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	168	Ig-like C2-type 2.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAACAAATCTCTTTTCTGGGT	0.383			Mis		"NSCLC, angiosarcoma"					TSP Lung(20;0.16)			3	14					1	1	1	1	0	A	55981195	C	A	55981195	3	1	11	1	0	0	0	0	1	0	0	0	8181	912	32	2	3670	2	KDR	4	55981195	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08		55981195	135173081	14	733										
FRAS1	80144	broad.mit.edu	37	chr4	79362391	79362391	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	atgatgacaacctccagagaGatgccatcattaaactaagt	7	9	1	4			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr4:79362391G>C	ENST00000264895.6	+	41	6045	c.5605G>C	c.(5605-5607)Gat>Cat	p.D1869H	FRAS1_ENST00000325942.6_Missense_Mutation_p.D1869H	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1868					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CCTCCAGAGAGATGCCATCAT	0.423													5	10					0	0	1	0	0	C	79362391	G	C	79362391	3	2	11	1	0	0	0	0	1	0	0	0	6075	942	33	2	5767	2	FRAS1	4	79362391	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	23381196	79362391	111791885	15	734										
NPNT	255743	broad.mit.edu	37	chr4	106863781	106863781	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tgacaactatagcaccagctGccagtacacctccaggaggg	10	13	0	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr4:106863781G>T	ENST00000379987.2	+	8	1297	c.1081G>T	c.(1081-1083)Gcc>Tcc	p.A361S	NPNT_ENST00000305572.8_Missense_Mutation_p.A361S|NPNT_ENST00000506666.1_Missense_Mutation_p.A391S|NPNT_ENST00000453617.2_Missense_Mutation_p.A378S|NPNT_ENST00000514622.1_Missense_Mutation_p.A361S|NPNT_ENST00000427316.2_Missense_Mutation_p.A391S	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	361	Pro-rich.				cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		AGCACCAGCTGCCAGTACACC	0.517													13	84					9.31168e-06	1.04636e-05	1	1	0	T	106863781	G	T	106863781	3	4	11	1	0	0	0	0	1	0	0	0	10637	1319	46	5	1260	5	NPNT	4	106863781	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	27501390	106863781	84290495	16	735										
NAA15	80155	broad.mit.edu	37	chr4	140272382	140272382	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ctaaaaatttatgaggaagcCtggactaaatatcccagggg	10	7	0	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr4:140272382C>T	ENST00000296543.5	+	8	1172	c.849C>T	c.(847-849)gcC>gcT	p.A283A	NAA15_ENST00000398947.1_Silent_p.A283A|NAA15_ENST00000480277.2_3'UTR	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	283					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						ATGAGGAAGCCTGGACTAAAT	0.318													14	6					0	0	1	0	0	T	140272382	C	T	140272382	2	4	11	1	0	0	0	0	0	0	0	1	10165	668	24	3		3	NAA15	4	140272382	Silent	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	33408601	140272382	50881894	17	736										
KLKB1	3818	broad.mit.edu	37	chr4	187179284	187179284	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ggagcaacctggtgtctacaCcaaagtcgctgagtacatgg	12	10	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr4:187179284C>A	ENST00000264690.6	+	15	2022	c.1835C>A	c.(1834-1836)aCc>aAc	p.T612N	KLKB1_ENST00000513864.1_3'UTR	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	612	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGTGTCTACACCAAAGTCGCT	0.517													24	37					2.39556e-15	2.83822e-15	1	1	0	A	187179284	C	A	187179284	3	1	11	1	0	0	0	0	1	0	0	0	8454	507	18	5	1889	5	KLKB1	4	187179284	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	46906902	187179284	3974992	18	737										
ENC1	8507	broad.mit.edu	37	chr5	73932112	73932112	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ggcctcaaagtagcgactgcAtgcagccagcactgcccggt	12	14	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr5:73932112A>G	ENST00000302351.4	-	2	1329	c.199T>C	c.(199-201)Tgc>Cgc	p.C67R	ENC1_ENST00000537006.1_Missense_Mutation_p.C67R|ENC1_ENST00000510316.1_5'UTR	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	67	BTB.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		TAGCGACTGCATGCAGCCAGC	0.542													19	8					0	0	1	0	0	G	73932112	A	G	73932112	3	3	11	1	0	0	0	0	1	0	0	0	5141	217	8	4	1574	4	ENC1	5	73932112	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08		73932112	106983148	19	738										
RAPGEF6	51735	broad.mit.edu	37	chr5	130785715	130785715	+	Splice_Site	DEL	C	C	-													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tgcgttcatctctacacttaCcccagactccgccacctctt							TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr5:130785715delC	ENST00000307984.5	-	23	3445		c.e23+1		RAPGEF6_ENST00000509018.1_Intron|RAPGEF6_ENST00000296859.6_Splice_Site|RAPGEF6_ENST00000507093.1_Splice_Site|FNIP1_ENST00000514667.1_Intron|RAPGEF6_ENST00000308008.6_Intron|RAPGEF6_ENST00000512052.1_Splice_Site	NM_001164387.1	NP_001157859.1	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCTACACTTACCCCAGACTCC	0.408													2	4	---	---	---	---						-	130785715	C	-	130785715	8	5	11	1	0	1	0	1	0	0	1	0	13099	521	18	0	2071	0	RAPGEF6	5	130785715	Splice_Site	DEL	C	TCGA-N5-A4RU-01A-31D-A28R-08	56853603	130785715	50129545	20	739										
GPX3	2878	broad.mit.edu	37	chr5	150405020	150405020	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tacgtcctctttgtcaacgtGgccagctactgaggcctgac	10	13	2	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr5:150405020G>A	ENST00000388825.4	+	2	299	c.207G>A	c.(205-207)gtG>gtA	p.V69V	GPX3_ENST00000521722.1_3'UTR|GPX3_ENST00000517973.1_Intron	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	69					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	TTGTCAACGTGGCCAGCTACT	0.517													7	42					0	0	1	0	0	A	150405020	G	A	150405020	2	1	11	1	0	0	0	0	0	0	0	1	6781	1335	47	3		3	GPX3	5	150405020	Silent	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	19619305	150405020	30510240	21	740										
GRM6	2916	broad.mit.edu	37	chr5	178413522	178413522	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	agggggaggaccagctcaggCgcaccacaggtgtggggcgg	20	10	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr5:178413522C>T	ENST00000231188.5	-	8	1911	c.1733G>A	c.(1732-1734)cGc>cAc	p.R578H	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.R578H	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	578					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CCAGCTCAGGCGCACCACAGG	0.697													21	6					0	0	1	0	0	T	178413522	C	T	178413522	3	4	11	1	0	0	0	0	1	0	0	0	6841	768	27	1	912	1	GRM6	5	178413522	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	28008502	178413522	2501738	22	741										
RREB1	6239	broad.mit.edu	37	chr6	7230164	7230164	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cctgctgccgctgagcatggAggccaagatcaagcaggaga	14	11	1	3			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:7230164A>T	ENST00000379938.2	+	10	2369	c.1832A>T	c.(1831-1833)gAg>gTg	p.E611V	RREB1_ENST00000349384.6_Missense_Mutation_p.E611V|RREB1_ENST00000379933.3_Missense_Mutation_p.E611V|RREB1_ENST00000334984.6_Missense_Mutation_p.E611V	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	611					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTGAGCATGGAGGCCAAGATC	0.657													4	53					0	0	1	0	0	T	7230164	A	T	7230164	3	4	11	1	0	0	0	0	1	0	0	0	13730	304	11	4	1858	4	RREB1	6	7230164	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08		7230164	163884903	23	742										
DSP	1832	broad.mit.edu	37	chr6	7585361	7585361	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tcgagccccattgcagccatCtttgacacagaaaacctgga	8	13	1	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:7585361C>T	ENST00000379802.3	+	24	8207	c.7866C>T	c.(7864-7866)atC>atT	p.I2622I	DSP_ENST00000418664.2_Silent_p.I2023I	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2622	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTGCAGCCATCTTTGACACAG	0.488													22	81					0	0	1	0	0	T	7585361	C	T	7585361	2	4	11	1	0	0	0	0	0	0	0	1	4807	903	32	3		3	DSP	6	7585361	Silent	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	355197	7585361	163529706	24	743										
HMGN3	9324	broad.mit.edu	37	chr6	79918282	79918282	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	accgctgacaatctggcagaCcgtcttgtgggctacaaagg	12	11	2	2	rs114465555	by1000genomes	TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:79918282C>G	ENST00000344726.5	-	3	206	c.78G>C	c.(76-78)cgG>cgC	p.R26R	HMGN3_ENST00000275036.7_Silent_p.R26R	NM_001201362.1|NM_001201363.1|NM_004242.3	NP_001188291.1|NP_001188292.1|NP_004233.1	Q15651	HMGN3_HUMAN	high mobility group nucleosomal binding domain 3	26					chromatin modification	chromatin|cytoplasm|nucleus	DNA binding|thyroid hormone receptor binding			central_nervous_system(1)|kidney(2)|lung(1)	4		all_cancers(76;0.000116)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0393)		BRCA - Breast invasive adenocarcinoma(397;0.125)		ATCTGGCAGACCGTCTTGTGG	0.353													27	100					0	0	1	0	0	G	79918282	C	G	79918282	2	3	11	1	0	0	0	0	0	0	0	1	7276	494	18	5		5	HMGN3	6	79918282	Silent	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	72332921	79918282	91196785	25	744										
DOPEY1	23033	broad.mit.edu	37	chr6	83839206	83839206	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ggaaccatacatcagagttaCgttctgaaaaattggagact	9	7	2	3			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:83839206C>A	ENST00000349129.2	+	16	2580	c.2320C>A	c.(2320-2322)Cgt>Agt	p.R774S	DOPEY1_ENST00000369739.3_Missense_Mutation_p.R765S|DOPEY1_ENST00000237163.5_Missense_Mutation_p.R755S	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	774					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ATCAGAGTTACGTTCTGAAAA	0.393													8	24					0.00621372	0.00651245	1	1	0	A	83839206	C	A	83839206	3	1	11	1	0	0	0	0	1	0	0	0	4734	536	19	5	2374	5	DOPEY1	6	83839206	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	3920924	83839206	87275861	26	745										
CNR1	0	broad.mit.edu	37	chr6	88854544	88854544	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ccgatgaagtggtaggaaggCctgcagcggaggctgcggga	19	8	0	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:88854544C>G	ENST00000537554.1	-	2	4012	c.450G>C	c.(448-450)agG>agC	p.R150S	CNR1_ENST00000369501.2_Missense_Mutation_p.R150S|CNR1_ENST00000468898.1_Missense_Mutation_p.R117S|CNR1_ENST00000549716.1_Missense_Mutation_p.R89S|CNR1_ENST00000549890.1_Missense_Mutation_p.R150S|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000369499.2_Missense_Mutation_p.R150S|CNR1_ENST00000535130.1_Missense_Mutation_p.R150S|CNR1_ENST00000428600.2_Missense_Mutation_p.R150S	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	150					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GGTAGGAAGGCCTGCAGCGGA	0.602													3	28					0	0	1	0	0	G	88854544	C	G	88854544	3	3	11	1	0	0	0	0	1	0	0	0	3654	738	26	5	972	5	CNR1	6	88854544	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	5015338	88854544	82260523	27	746										
TAAR5	9038	broad.mit.edu	37	chr6	132910256	132910256	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ttgagcagcagctggcaactGcccacacaaggcatctcttc	9	14	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:132910256G>T	ENST00000258034.2	-	1	621	c.570C>A	c.(568-570)ggC>ggA	p.G190G		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	190					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GCTGGCAACTGCCCACACAAG	0.498													6	68					0.00116845	0.001261	1	1	0	T	132910256	G	T	132910256	2	4	11	1	0	0	0	0	0	0	0	1	15547	1306	46	5		5	TAAR5	6	132910256	Silent	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	44055712	132910256	38204811	28	747										
ARID1B	57492	broad.mit.edu	37	chr6	157528639	157528639	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tagttaggtacgttggggatCgcaaaaacccagtctgtcga	12	8	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr6:157528639C>T	ENST00000346085.5	+	20	6365	c.6364C>T	c.(6364-6366)Cgc>Tgc	p.R2122C	ARID1B_ENST00000367148.1_Missense_Mutation_p.R2162C|ARID1B_ENST00000350026.5_Missense_Mutation_p.R2109C|ARID1B_ENST00000275248.4_Missense_Mutation_p.R2104C	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2109					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CGTTGGGGATCGCAAAAACCC	0.488													39	176					0	0	1	0	0	T	157528639	C	T	157528639	3	4	11	1	0	0	0	0	1	0	0	0	911	884	31	1	6442	1	ARID1B	6	157528639	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	24618383	157528639	13586428	29	748										
PURB	5814	broad.mit.edu	37	chr7	44924851	44924851	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cagccgcttcgaggccagctCctgcgtctcttgctcgccgc	11	18	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr7:44924851C>G	ENST00000395699.2	-	1	109	c.97G>C	c.(97-99)Gag>Cag	p.E33Q		NM_033224.3	NP_150093.1	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	33					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding			large_intestine(2)|lung(3)|prostate(1)|skin(1)	7						GAGGCCAGCTCCTGCGTCTCT	0.697													3	21					0	0	1	0	0	G	44924851	C	G	44924851	3	3	11	1	0	0	0	0	1	0	0	0	12879	864	30	2	845	2	PURB	7	44924851	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08		44924851	114213812	30	749										
TRIM56	81844	broad.mit.edu	37	chr7	100732400	100732400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cactgcctagcggggaccgcGtggctgtcagcgtggcgggc	18	13	1	0	rs111492335		TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr7:100732400G>A	ENST00000306085.6	+	3	2104	c.1807G>A	c.(1807-1809)Gtg>Atg	p.V603M		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	603					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CGGGGACCGCGTGGCTGTCAG	0.692													5	86					0	0	1	0	0	A	100732400	G	A	100732400	3	1	11	1	0	0	0	0	1	0	0	0	16590	1145	40	1	1809	1	TRIM56	7	100732400	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	55807549	100732400	58406263	31	750										
CNPY1	285888	broad.mit.edu	37	chr7	155301672	155301672	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tttgtctcctttcctaggagCgaatctcttgaaagttctct	7	10	3	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr7:155301672C>A	ENST00000321736.5	-	2	223	c.61G>T	c.(61-63)Gct>Tct	p.A21S	CNPY1_ENST00000406197.1_Missense_Mutation_p.A21S	NM_001103176.1	NP_001096646.1	Q3B7I2	CNPY1_HUMAN	canopy FGF signaling regulator 1	21								p.A21T(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	8	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TTCCTAGGAGCGAATCTCTTG	0.403													6	18					0.0215528	0.0221627	1	1	0	A	155301672	C	A	155301672	3	1	11	1	0	0	0	0	1	0	0	0	3650	768	27	5	229	5	CNPY1	7	155301672	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	54569272	155301672	3836991	32	751										
SLC45A4	57210	broad.mit.edu	37	chr8	142228295	142228312	+	In_Frame_Del	DEL	CCCCGCTGGAGGTGGTGG	CCCCGCTGGAGGTGGTGG	-													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cccctcctcactctcggtgtCcccgctggaggtggtggccc							TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr8:142228295_142228312delCCCCGCTGGAGGTGGTGG	ENST00000519067.1	-	4	1577_1594	c.1274_1291delCCACCACCTCCAGCGGGG	c.(1273-1293)gac>g	p.ATTSSGD425del	SLC45A4_ENST00000517878.1_In_Frame_Del_p.ATTSSGD476del|SLC45A4_ENST00000024061.3_In_Frame_Del_p.ATTSSGD425del|SLC45A4_ENST00000433583.2_In_Frame_Del_p.ATTSSGD418del			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	476					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CTCTCGGTGTCCCCGCTGGAGGTGGTGGCCCCGCTCTG	0.679													7	106	---	---	---	---						-	142228312	CCCCGCTGGAGGTGGTGG	-	142228295	7	5	11	1	0	1	0	1	0	0	0	0	14697	855	30	0	1125	0	SLC45A4	8	142228295	In_Frame_Del	DEL	CCCCGCTGGAGGTGGTGG	TCGA-N5-A4RU-01A-31D-A28R-08		142228295	4135727	33	752										
SMARCA2	6595	broad.mit.edu	37	chr9	2054608	2054608	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ttcctttagacttcaggcccGcatagctcataggatacaag	8	11	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr9:2054608G>A	ENST00000382203.1	+	6	1267	c.1058G>A	c.(1057-1059)cGc>cAc	p.R353H	SMARCA2_ENST00000382194.1_Missense_Mutation_p.R353H|SMARCA2_ENST00000349721.2_Missense_Mutation_p.R353H|SMARCA2_ENST00000357248.2_Missense_Mutation_p.R353H			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	353					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CTTCAGGCCCGCATAGCTCAT	0.398													4	76					0	0	1	0	0	A	2054608	G	A	2054608	3	1	11	1	0	0	0	0	1	0	0	0	14822	1087	38	1	1076	1	SMARCA2	9	2054608	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		2054608	139158823	34	753										
ZNF33A	7581	broad.mit.edu	37	chr10	38344803	38344803	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ggagaaaccctacgaatgtcAtgaatgtggaaaaatctttt	9	6	2	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr10:38344803A>T	ENST00000374618.3	+	5	1929	c.1751A>T	c.(1750-1752)cAt>cTt	p.H584L	ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000307441.9_Missense_Mutation_p.H583L|ZNF33A_ENST00000458705.2_Missense_Mutation_p.H583L|ZNF33A_ENST00000432900.2_Missense_Mutation_p.H590L	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	583						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						TACGAATGTCATGAATGTGGA	0.378													25	49					0	0	1	0	0	T	38344803	A	T	38344803	3	4	11	1	0	0	0	0	1	0	0	0	17910	217	8	4	1765	4	ZNF33A	10	38344803	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08		38344803	97189944	35	754										
PCDH15	65217	broad.mit.edu	37	chr10	55568610	55568610	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tgattctgattcctcctcacTttccacacctccttccaccg	3	18	2	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr10:55568610T>C	ENST00000395445.1	-	36	5594	c.5200A>G	c.(5200-5202)Agt>Ggt	p.S1734G	PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.S930G|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.S668G|PCDH15_ENST00000395442.1_Missense_Mutation_p.S599G|PCDH15_ENST00000395438.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCTCCTCACTTTCCACACCT	0.507										HNSCC(58;0.16)			5	8					0	0	1	0	0	C	55568610	T	C	55568610	3	2	11	1	0	0	0	0	1	0	0	0	11557	1609	56	4	716	4	PCDH15	10	55568610	Missense_Mutation	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08	17223807	55568610	79966137	36	755										
IFIT1	3434	broad.mit.edu	37	chr10	91162764	91162764	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	aagtacattgaagaagctctAgccaacatgtcctcacagac	7	11	2	3			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr10:91162764A>G	ENST00000546318.1	+	2	1926	c.639A>G	c.(637-639)ctA>ctG	p.L213L	LIPA_ENST00000371837.1_Intron|IFIT1_ENST00000371804.3_Silent_p.L244L	NM_001270928.1|NM_001270929.1|NM_001270930.1	NP_001257857.1|NP_001257858.1|NP_001257859.1	P09914	IFIT1_HUMAN	interferon-induced protein with tetratricopeptide repeats 1	244					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	15						AAGAAGCTCTAGCCAACATGT	0.418													102	62					0	0	1	0	0	G	91162764	A	G	91162764	2	3	11	1	0	0	0	0	0	0	0	1	7564	407	15	4		4	IFIT1	10	91162764	Silent	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08	35594154	91162764	44371983	37	756										
FAM178A	0	broad.mit.edu	37	chr10	102689755	102689755	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gtagaaaaacttattcttaaGtaagtagaaaaatagacatt	6	3	1	3			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr10:102689755G>A	ENST00000238961.3	+	8	2481		c.e8+1		FAM178A_ENST00000370269.3_Splice_Site	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A																		TTATTCTTAAGTAAGTAGAAA	0.264													6	13					0	0	1	0	0	A	102689755	G	A	102689755	5	1	11	1	0	0	0	0	0	0	1	0	5532	1043	36	3	2364	3	FAM178A	10	102689755	Splice_Site	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	11526991	102689755	32844992	38	757										
FAM160B1	57700	broad.mit.edu	37	chr10	116606948	116606948	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cctcctgctactccagaccaCcccaaaaatgatggaaaaac	5	15	0	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr10:116606948C>G	ENST00000369248.4	+	12	2003	c.1668C>G	c.(1666-1668)caC>caG	p.H556Q	FAM160B1_ENST00000369250.3_Missense_Mutation_p.H556Q	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	556										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						CTCCAGACCACCCCAAAAATG	0.353													3	22					0	0	1	0	0	G	116606948	C	G	116606948	3	3	11	1	0	0	0	0	1	0	0	0	5500	506	18	5	1714	5	FAM160B1	10	116606948	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	13917193	116606948	18927799	39	758										
OR8H2	390151	broad.mit.edu	37	chr11	55872940	55872940	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tattatgtccaaaaggctctGcctcgctctcatcactgggc	8	13	3	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr11:55872940G>T	ENST00000313503.1	+	1	422	c.422G>T	c.(421-423)tGc>tTc	p.C141F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAAAGGCTCTGCCTCGCTCTC	0.458										HNSCC(53;0.14)			12	424					7.03913e-09	8.07647e-09	1	1	0	T	55872940	G	T	55872940	3	4	11	1	0	0	0	0	1	0	0	0	11284	1319	46	5	424	5	OR8H2	11	55872940	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		55872940	79133576	40	759										
SART1	9092	broad.mit.edu	37	chr11	65729347	65729347	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	accgagcagccgccgcggcaCcgggaacacaaaaaacacaa	10	15	0	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr11:65729347C>T	ENST00000312397.5	+	1	188	c.96C>T	c.(94-96)caC>caT	p.H32H	SART1_ENST00000528573.1_3'UTR	NM_005146.4	NP_005137.1	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T cells	32					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						cgccgcggcaccgggaacaca	0.721													3	9					0	0	1	0	0	T	65729347	C	T	65729347	2	4	11	1	0	0	0	0	0	0	0	1	13898	506	18	3		3	SART1	11	65729347	Silent	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	9856407	65729347	69277169	41	760										
TYR	7299	broad.mit.edu	37	chr11	88924523	88924523	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tagaattttgcctgagtttgAcccaatatgaatctggttcc	8	8	1	4	rs61754379		TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr11:88924523A>G	ENST00000263321.5	+	2	1475	c.973A>G	c.(973-975)Acc>Gcc	p.T325A	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	325			T -> A (in OCA1B).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CCTGAGTTTGACCCAATATGA	0.418													31	79					0	0	1	0	0	G	88924523	A	G	88924523	3	3	11	1	0	0	0	0	1	0	0	0	16874	275	10	4	979	4	TYR	11	88924523	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08	23195176	88924523	46081993	42	761										
CNTN5	53942	broad.mit.edu	37	chr11	99932018	99932018	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	acgtctgcggaaatctcaggCggtgctggaaataccgaatg	13	9	2	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr11:99932018C>T	ENST00000524871.1	+	10	1345	c.1055C>T	c.(1054-1056)gCg>gTg	p.A352V	CNTN5_ENST00000527185.1_Missense_Mutation_p.A352V|CNTN5_ENST00000528682.1_Missense_Mutation_p.A352V|CNTN5_ENST00000418526.2_Missense_Mutation_p.A278V|CNTN5_ENST00000279463.3_Missense_Mutation_p.A352V	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	352	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding	p.A352V(2)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAATCTCAGGCGGTGCTGGAA	0.433													35	34					0	0	1	0	0	T	99932018	C	T	99932018	3	4	11	1	0	0	0	0	1	0	0	0	3667	768	27	1	1085	1	CNTN5	11	99932018	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	11007495	99932018	35074498	43	762										
MPZL3	196264	broad.mit.edu	37	chr11	118107897	118107897	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tatagatgcatcccctttgtAtacatttccaacccaggaaa	5	11	0	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr11:118107897A>G	ENST00000278949.4	-	3	374	c.319T>C	c.(319-321)Tac>Cac	p.Y107H	MPZL3_ENST00000527472.1_Missense_Mutation_p.Y95H|MPZL3_ENST00000525386.1_Intron			Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3	107	Ig-like V-type.				cell adhesion	integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TCCCCTTTGTATACATTTCCA	0.423													55	70					0	0	1	0	0	G	118107897	A	G	118107897	3	3	11	1	0	0	0	0	1	0	0	0	9799	449	16	4	404	4	MPZL3	11	118107897	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08	18175879	118107897	16898619	44	763										
LRP1	4035	broad.mit.edu	37	chr12	57571295	57571295	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ctgggcgccgcaccgtgcacCgggagaccggctctgggggc	18	15	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr12:57571295C>T	ENST00000243077.3	+	26	4748	c.4282C>T	c.(4282-4284)Cgg>Tgg	p.R1428W		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1428					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CACCGTGCACCGGGAGACCGG	0.667													19	31					0	0	1	0	0	T	57571295	C	T	57571295	3	4	11	1	0	0	0	0	1	0	0	0	8995	643	23	1	4384	1	LRP1	12	57571295	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08		57571295	76280600	45	764										
LRCH1	23143	broad.mit.edu	37	chr13	47262018	47262018	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gggcaaagttcacatatttaAgtatctgagcatacaagcat	8	7	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr13:47262018A>C	ENST00000311191.6	+	6	1083	c.854A>C	c.(853-855)aAg>aCg	p.K285T	LRCH1_ENST00000389797.3_Missense_Mutation_p.K285T|LRCH1_ENST00000389798.3_Missense_Mutation_p.K285T	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	285										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CACATATTTAAGTATCTGAGC	0.373													7	29					0	0	1	0	0	C	47262018	A	C	47262018	3	2	11	1	0	0	0	0	1	0	0	0	8976	72	3	4	876	4	LRCH1	13	47262018	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08		47262018	67907860	46	765										
EFNB2	1948	broad.mit.edu	37	chr13	107165066	107165066	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ataaactttataatattcatActggccaacagttttagagt	5	6	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr13:107165066A>C	ENST00000245323.4	-	2	366	c.217T>G	c.(217-219)Tat>Gat	p.Y73D		NM_004093.3	NP_004084.1	P52799	EFNB2_HUMAN	ephrin-B2	73					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					TAATATTCATACTGGCCAACA	0.388													8	53					0	0	1	0	0	C	107165066	A	C	107165066	3	2	11	1	0	0	0	0	1	0	0	0	4982	391	14	4	800	4	EFNB2	13	107165066	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08	59903048	107165066	8004812	47	766										
VPS18	57617	broad.mit.edu	37	chr15	41192287	41192287	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gcggcccgactgcctggacaCggtcctggcccgggaggccg	17	16	0	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr15:41192287C>G	ENST00000220509.5	+	4	1610	c.1271C>G	c.(1270-1272)aCg>aGg	p.T424R	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	424					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TGCCTGGACACGGTCCTGGCC	0.617													7	68					0	0	1	0	0	G	41192287	C	G	41192287	3	3	11	1	0	0	0	0	1	0	0	0	17253	536	19	5	1285	5	VPS18	15	41192287	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08		41192287	61339105	48	767										
TLN2	83660	broad.mit.edu	37	chr15	63084975	63084975	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tgatcgaatgcgcccgtgccGtcacggaaaaggtaaggagc	14	10	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr15:63084975G>A	ENST00000561311.1	+	45	6102	c.5872G>A	c.(5872-5874)Gtc>Atc	p.V1958I	TLN2_ENST00000306829.6_Missense_Mutation_p.V1958I			Q9Y4G6	TLN2_HUMAN	talin 2	1958					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CGCCCGTGCCGTCACGGAAAA	0.577													8	19					0	0	1	0	0	A	63084975	G	A	63084975	3	1	11	1	0	0	0	0	1	0	0	0	16007	1145	40	1	6042	1	TLN2	15	63084975	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	21892688	63084975	39446417	49	768										
MAN2A2	4122	broad.mit.edu	37	chr15	91447499	91447499	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cttctgtgtggcagtcttctCgctctacctcatgctggacc	9	14	5	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr15:91447499C>G	ENST00000360468.3	+	1	80	c.62C>G	c.(61-63)tCg>tGg	p.S21W	MAN2A2_ENST00000559717.1_Missense_Mutation_p.S21W	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	21					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GCAGTCTTCTCGCTCTACCTC	0.557													25	44					0	0	1	0	0	G	91447499	C	G	91447499	3	3	11	1	0	0	0	0	1	0	0	0	9264	893	31	2	64	2	MAN2A2	15	91447499	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	28362524	91447499	11083893	50	769										
NLRC3	197358	broad.mit.edu	37	chr16	3613453	3613453	+	RNA	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gcccgctgggctgcgctcctGaaatgcgtgaggaagcccag	15	13	0	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr16:3613453G>A	ENST00000301749.7	-	0	1890				NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTGCGCTCCTGAAATGCGTGA	0.642													5	4					0	0	1	0	0	A	3613453	G	A	3613453	1	1	11	0	1	0	0	0	0	0	0	0	10514	1281	45	3		3	NLRC3	16	3613453	RNA	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		3613453	86741300	51	770										
MMP2	0	broad.mit.edu	37	chr16	55523609	55523609	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gaaggtgccccctgtgtcttCcccttcactttcctgggcaa	9	15	2	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr16:55523609C>A	ENST00000219070.4	+	7	1562	c.1053C>A	c.(1051-1053)ttC>ttA	p.F351L	MMP2_ENST00000570308.1_Missense_Mutation_p.F275L|MMP2_ENST00000543485.1_Missense_Mutation_p.F275L|MMP2_ENST00000437642.2_Missense_Mutation_p.F301L	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	351	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CCTGTGTCTTCCCCTTCACTT	0.577													28	49					2.44723e-14	2.86826e-14	1	1	0	A	55523609	C	A	55523609	3	1	11	1	0	0	0	0	1	0	0	0	9705	854	30	2	1086	2	MMP2	16	55523609	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	51910156	55523609	34831144	52	771										
CDK10	8558	broad.mit.edu	37	chr16	89762026	89762026	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gtgagccggagctcatgccgAcctttccccaccaccgcaac	9	18	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr16:89762026A>C	ENST00000331006.8	+	12	2609	c.868A>C	c.(868-870)Acc>Ccc	p.T290P	CDK10_ENST00000505473.1_Intron|CDK10_ENST00000353379.7_Missense_Mutation_p.T337P			Q15131	CDK10_HUMAN	cyclin-dependent kinase 10	337	Protein kinase.				negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		GCTCATGCCGACCTTTCCCCA	0.672													5	9					0	0	1	0	0	C	89762026	A	C	89762026	3	2	11	1	0	0	0	0	1	0	0	0	3147	275	10	4	1059	4	CDK10	16	89762026	Missense_Mutation	SNP	A	TCGA-N5-A4RU-01A-31D-A28R-08	34238417	89762026	592727	53	772										
TP53	7157	broad.mit.edu	37	chr17	7578395	7578395	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gctatctgagcagcgctcatGgtgggggcagcgcctcacaa	14	12	3	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr17:7578395G>C	ENST00000420246.2	-	5	667	c.535C>G	c.(535-537)Cat>Gat	p.H179D	TP53_ENST00000574684.1_5'UTR|TP53_ENST00000413465.2_Missense_Mutation_p.H179D|TP53_ENST00000269305.4_Missense_Mutation_p.H179D|TP53_ENST00000359597.4_Missense_Mutation_p.H179D|TP53_ENST00000455263.2_Missense_Mutation_p.H179D|TP53_ENST00000445888.2_Missense_Mutation_p.H179D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	179	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179Y(98)|p.H179N(16)|p.H179D(13)|p.P177_C182delPHHERC(8)|p.0?(8)|p.H47Y(6)|p.H86Y(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H178_S183delHHERCS(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.H179fs*68(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H46_S51delHHERCS(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H85_S90delHHERCS(1)|p.H47D(1)|p.R174fs*3(1)|p.H86D(1)|p.H178_H179>QY(1)|p.H47N(1)|p.H86N(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	7					0	0	1	0	0	C	7578395	G	C	7578395	3	2	11	1	0	0	0	0	1	0	0	0	16441	1348	47	5	763	5	TP53	17	7578395	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		7578395	73616815	54	773										
GPATCH8	23131	broad.mit.edu	37	chr17	42478776	42478776	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tcttctccaccttcttcatcTacagccactgtggttggttt	6	13	5	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr17:42478776T>C	ENST00000434000.1	-	9	717	c.435A>G	c.(433-435)gtA>gtG	p.V145V	GPATCH8_ENST00000591680.1_Silent_p.V223V			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	223						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CTTCTTCATCTACAGCCACTG	0.418													22	63					0	0	1	0	0	C	42478776	T	C	42478776	2	2	11	1	0	0	0	0	0	0	0	1	6633	1509	53	4		4	GPATCH8	17	42478776	Silent	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08	34900381	42478776	38716434	55	774										
SEPT9	10801	broad.mit.edu	37	chr17	75471732	75471732	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gctccagtgtgcattgttacGaggcaaagtaaggagactgc	13	8	0	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr17:75471732G>A	ENST00000427180.1	+	1	408	c.132G>A	c.(130-132)acG>acA	p.T44T	SEPT9_ENST00000423034.2_Intron|SEPT9_ENST00000427674.2_Intron|SEPT9_ENST00000591198.1_Intron|SEPT9_ENST00000449803.2_Intron|SEPT9_ENST00000541152.2_Intron|SEPT9_ENST00000590294.1_Intron|SEPT9_ENST00000588690.1_Intron|SEPT9_ENST00000427177.1_Intron|SEPT9_ENST00000592951.1_Intron|SEPT9_ENST00000592481.1_Intron|SEPT9_ENST00000431235.2_Intron|SEPT9_ENST00000590917.1_Intron|SEPT9_ENST00000585930.1_Intron|SEPT9_ENST00000592420.1_Intron|SEPT9_ENST00000329047.8_Intron|SEPT9_ENST00000591088.1_Intron	NM_001113495.1	NP_001106967.1	Q9UHD8	SEPT9_HUMAN	septin 9	235					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			GCATTGTTACGAGGCAAAGTA	0.667													7	17					0	0	1	0	0	A	75471732	G	A	75471732	2	1	11	1	0	0	0	0	0	0	0	1	14124	1045	37	1		1	SEPT9	17	75471732	Silent	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	32992956	75471732	5723478	56	775										
DTNA	1837	broad.mit.edu	37	chr18	32459673	32459673	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gagctaccacaagtaccatgCgtggcgacatgtgagtatct	11	10	1	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr18:32459673C>T	ENST00000283365.9	+	19	2251	c.1900C>T	c.(1900-1902)Cgt>Tgt	p.R634C	DTNA_ENST00000595022.1_Missense_Mutation_p.R631C|DTNA_ENST00000444659.1_Missense_Mutation_p.R691C|DTNA_ENST00000598334.1_Missense_Mutation_p.R631C|DTNA_ENST00000269192.7_Missense_Mutation_p.R400C|DTNA_ENST00000598142.1_Missense_Mutation_p.R634C|DTNA_ENST00000591182.1_Missense_Mutation_p.R339C|DTNA_ENST00000601125.1_Missense_Mutation_p.R313C|DTNA_ENST00000399113.3_Missense_Mutation_p.R691C|DTNA_ENST00000399121.5_Missense_Mutation_p.R638C|DTNA_ENST00000590831.2_Missense_Mutation_p.R117C|DTNA_ENST00000269190.7_Missense_Mutation_p.R692C|DTNA_ENST00000556414.3_Missense_Mutation_p.R343C|DTNA_ENST00000399097.3_Missense_Mutation_p.R339C	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	691					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding	p.R339C(1)|p.R691C(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						AAGTACCATGCGTGGCGACAT	0.433													4	23					0	0	1	0	0	T	32459673	C	T	32459673	3	4	11	1	0	0	0	0	1	0	0	0	4814	768	27	1	2235	1	DTNA	18	32459673	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08		32459673	45617575	57	776										
MBD1	4152	broad.mit.edu	37	chr18	47796419	47796419	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	aatttcatatagatcattgtCaaaattaccagaatactggg	6	6	3	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr18:47796419C>A	ENST00000339998.6	-	14	1753	c.1615G>T	c.(1615-1617)Gac>Tac	p.D539Y	MBD1_ENST00000591416.1_3'UTR|MBD1_ENST00000590208.1_Intron|MBD1_ENST00000587605.1_Intron|MBD1_ENST00000269468.5_Intron|MBD1_ENST00000588937.1_Intron|MBD1_ENST00000269471.5_Intron|MBD1_ENST00000585672.1_Intron|MBD1_ENST00000585595.1_Intron|MBD1_ENST00000436910.1_Intron|MBD1_ENST00000424334.2_Intron|MBD1_ENST00000382948.5_Intron|MBD1_ENST00000353909.3_Intron|MBD1_ENST00000349085.2_Intron|MBD1_ENST00000347968.3_Intron	NM_001204142.1	NP_001191071.1	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	0	TRD.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						AGATCATTGTCAAAATTACCA	0.408													7	82					0.00198382	0.00211996	1	1	0	A	47796419	C	A	47796419	3	1	11	1	0	0	0	0	1	0	0	0	9391	841	29	2		2	MBD1	18	47796419	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	15336746	47796419	30280829	58	777										
C19orf70	125988	broad.mit.edu	37	chr19	5679659	5679659	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gaactggtacatggcgggggGgaccacctccccagccttct	13	14	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:5679659G>T	ENST00000309324.4	-	2	554	c.145C>A	c.(145-147)Ccc>Acc	p.P49T	C19orf70_ENST00000587950.1_Missense_Mutation_p.P71T|C19orf70_ENST00000585605.1_5'UTR|C19orf70_ENST00000590389.1_Missense_Mutation_p.P71T|RPL36_ENST00000579649.1_Intron|C19orf70_ENST00000587589.1_Missense_Mutation_p.P49T	NM_205767.1	NP_991330.1	Q5XKP0	QIL1_HUMAN	chromosome 19 open reading frame 70	49							protein binding			endometrium(1)|lung(1)	2						ATGGCGGGGGGGACCACCTCC	0.657													10	22					2.17888e-05	2.42345e-05	1	1	0	T	5679659	G	T	5679659	3	4	11	1	0	0	0	0	1	0	0	0	1959	1232	43	5	223	5	C19orf70	19	5679659	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		5679659	53449324	59	778										
RPS28	6234	broad.mit.edu	37	chr19	8386953	8386953	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gagcgagaagcccggaggttGcgctgagcttggctgctcgc	17	11	0	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:8386953G>C	ENST00000600659.2	+	3	235	c.204G>C	c.(202-204)ttG>ttC	p.L68F		NM_001031.4	NP_001022.1	P62857	RS28_HUMAN	ribosomal protein S28	68					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome										CCCGGAGGTTGCGCTGAGCTT	0.602													4	8					0	0	1	0	0	C	8386953	G	C	8386953	3	2	11	1	0	0	0	0	1	0	0	0	13692	1310	46	5	214	5	RPS28	19	8386953	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	2707294	8386953	50742030	60	779										
NWD1	284434	broad.mit.edu	37	chr19	16870140	16870140	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gcccagcaaggagctgctgcGcttcccgcccctgctgtggg	14	16	0	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:16870140G>A	ENST00000524140.2	+	7	2292	c.1874G>A	c.(1873-1875)cGc>cAc	p.R625H	NWD1_ENST00000552788.1_Missense_Mutation_p.R625H|NWD1_ENST00000549814.1_Missense_Mutation_p.R625H|NWD1_ENST00000523826.1_Missense_Mutation_p.R419H|NWD1_ENST00000379808.3_Missense_Mutation_p.R625H|NWD1_ENST00000339803.6_Missense_Mutation_p.R490H	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	625	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAGCTGCTGCGCTTCCCGCCC	0.652													10	30					0	0	1	0	0	A	16870140	G	A	16870140	3	1	11	1	0	0	0	0	1	0	0	0	10828	1087	38	1	1479	1	NWD1	19	16870140	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	8483187	16870140	42258843	61	780										
ZNF585A	199704	broad.mit.edu	37	chr19	37647149	37647149	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	acctactgagagcaggtggcTgtaggtctccagcatcacat	11	11	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:37647149T>C	ENST00000356958.4	-	3	439	c.181A>G	c.(181-183)Agc>Ggc	p.S61G	ZNF585A_ENST00000392157.2_Missense_Mutation_p.S6G|ZNF585A_ENST00000292841.5_Missense_Mutation_p.S6G|ZNF585A_ENST00000588723.1_5'UTR|ZNF585A_ENST00000355533.2_Missense_Mutation_p.S6G			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGCAGGTGGCTGTAGGTCTCC	0.522													10	30					0	0	1	0	0	C	37647149	T	C	37647149	3	2	11	1	0	0	0	0	1	0	0	0	18073	1580	55	4	2140	4	ZNF585A	19	37647149	Missense_Mutation	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08	20777009	37647149	21481834	62	781										
SAMD4B	55095	broad.mit.edu	37	chr19	39868449	39868449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	acatccccagccagtttacaCgggtgatgggcaaaggtgag	13	10	0	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:39868449C>T	ENST00000314471.6	+	10	2464	c.1429C>T	c.(1429-1431)Cgg>Tgg	p.R477W	SAMD4B_ENST00000596368.1_Intron|SAMD4B_ENST00000598913.1_Missense_Mutation_p.R477W	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	477							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCAGTTTACACGGGTGATGGG	0.592													5	53					0	0	1	0	0	T	39868449	C	T	39868449	3	4	11	1	0	0	0	0	1	0	0	0	13873	527	19	1	1451	1	SAMD4B	19	39868449	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	2221300	39868449	19260534	63	782										
ZNF780A	284323	broad.mit.edu	37	chr19	40580527	40580527	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ttcaaagggtttctcaccagTatgcaatttctgatgtcgaa	8	8	3	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:40580527T>G	ENST00000450241.2	-	6	2031	c.1720A>C	c.(1720-1722)Act>Cct	p.T574P	ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000595687.2_Missense_Mutation_p.T608P|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000594395.1_Missense_Mutation_p.T609P|ZNF780A_ENST00000455521.1_Missense_Mutation_p.T609P|ZNF780A_ENST00000340963.5_Missense_Mutation_p.T608P			O75290	Z780A_HUMAN	zinc finger protein 780A	608					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTCTCACCAGTATGCAATTTC	0.413													7	76					0	0	1	0	0	G	40580527	T	G	40580527	3	3	11	1	0	0	0	0	1	0	0	0	18200	1638	57	4	234	4	ZNF780A	19	40580527	Missense_Mutation	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08	712078	40580527	18548456	64	783										
CEACAM5	1048	broad.mit.edu	37	chr19	42223865	42223865	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	acagcggagctgcccaagccCtccatctccagcaacaactc	7	18	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:42223865C>G	ENST00000221992.6	+	7	1623	c.1509C>G	c.(1507-1509)ccC>ccG	p.P503P	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Silent_p.P503P|CEACAM5_ENST00000398599.4_Silent_p.P502P	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	503	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TGCCCAAGCCCTCCATCTCCA	0.532													23	127					0	0	1	0	0	G	42223865	C	G	42223865	2	3	11	1	0	0	0	0	0	0	0	1	3217	668	24	5		5	CEACAM5	19	42223865	Silent	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	1643338	42223865	16905118	65	784										
SCAF1	58506	broad.mit.edu	37	chr19	50154615	50154615	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gacgagagcccccgcccggaCgcgcagcccacacagccgac	12	20	0	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:50154615C>T	ENST00000360565.3	+	7	1093	c.969C>T	c.(967-969)gaC>gaT	p.D323D		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	323					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCCGCCCGGACGCGCAGCCCA	0.697													13	8					0	0	1	0	0	T	50154615	C	T	50154615	2	4	11	1	0	0	0	0	0	0	0	1	13920	535	19	1		1	SCAF1	19	50154615	Silent	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	7930750	50154615	8974368	66	785										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715971	52715971	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cctgtgctcagatgacacccCcatggtgcggcgggccgcag	14	15	1	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:52715971C>T	ENST00000322088.6	+	5	594	c.536C>T	c.(535-537)cCc>cTc	p.P179L	PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124L	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612			Mis		clear cell ovarian carcinoma								42	7					0	0	1	0	0	T	52715971	C	T	52715971	3	4	11	1	0	0	0	0	1	0	0	0	12430	623	22	3	554	3	PPP2R1A	19	52715971	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	2561356	52715971	6413012	67	786										
PPP2R1A	5518	broad.mit.edu	37	chr19	52719088	52719088	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gacctggtccctgccttccaGaacctgatgaaagactgtga	10	12	0	5			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr19:52719088G>T	ENST00000322088.6	+	7	922	c.864G>T	c.(862-864)caG>caT	p.Q288H	PPP2R1A_ENST00000462990.1_Missense_Mutation_p.Q109H|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.Q233H	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	288	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ctgccttccagaacCTGATGA	0.612			Mis		clear cell ovarian carcinoma								16	60					4.7546e-09	5.51332e-09	1	1	0	T	52719088	G	T	52719088	3	4	11	1	0	0	0	0	1	0	0	0	12430	933	33	2	890	2	PPP2R1A	19	52719088	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	3117	52719088	6409895	68	787										
BAGE2	85319	broad.mit.edu	37	chr21	11048067	11048070	+	RNA	DEL	CTCT	CTCT	-													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	ctaaacaacttagactaaagCtctctgagtttcaggtataa					rs140519785		TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr21:11048067_11048070delCTCT	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tagactaaagctctctgagtttca	0.333													4	2	---	---	---	---						-	11048070	CTCT	-	11048067	6	5	11	0	1	1	0	1	0	0	0	0	1290	812	28	0		0	BAGE2	21	11048067	RNA	DEL	CTCT	TCGA-N5-A4RU-01A-31D-A28R-08		11048067	37081828	69	788										
BAGE2	85319	broad.mit.edu	37	chr21	11054219	11054220	+	RNA	INS	-	-	A													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	acaatgaagctaaatgaagtINSaaagggagcaaggttcttat					rs151065601		TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr21:11054219_11054220insA	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTAAATGAAGTAAAGGGAGCAA	0.361													3	5	---	---	---	---						A	11054220	-	A	11054219	6	5	11	0	1	1	1	0	0	0	0	0	1290	1653	57	0		0	BAGE2	21	11054219	RNA	INS	-	TCGA-N5-A4RU-01A-31D-A28R-08	6152	11054219	37075676	70	789										
BAGE2	85319	broad.mit.edu	37	chr21	11093134	11093135	+	RNA	INS	-	-	C													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	catttatctgttctcccctaINSccccccacaacgctatctac					rs141935972		TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr21:11093134_11093135insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTCTCCCCTACCCCCCACAAC	0.401													4	8	---	---	---	---						C	11093135	-	C	11093134	6	5	11	0	1	1	1	0	0	0	0	0	1290	406	14	0		0	BAGE2	21	11093134	RNA	INS	-	TCGA-N5-A4RU-01A-31D-A28R-08	38915	11093134	37036761	71	790										
TMPRSS15	5651	broad.mit.edu	37	chr21	19685352	19685352	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	atatgctctggattctgaacCgcactaaaccattgttgttc	7	10	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr21:19685352C>T	ENST00000284885.3	-	18	2108	c.2075G>A	c.(2074-2076)cGg>cAg	p.R692Q		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	692	SRCR.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						GATTCTGAACCGCACTAAACC	0.448													7	32					0	0	1	0	0	T	19685352	C	T	19685352	3	4	11	1	0	0	0	0	1	0	0	0	16305	652	23	1	1016	1	TMPRSS15	21	19685352	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	8592218	19685352	28444543	72	791										
B3GALT5	10317	broad.mit.edu	37	chr21	41033136	41033136	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cccaccattctgctccggcaCcggctacgtgttttctggcg	10	16	2	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr21:41033136C>G	ENST00000380620.3	+	5	1242	c.650C>G	c.(649-651)aCc>aGc	p.T217S	AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000380618.1_Missense_Mutation_p.T217S|B3GALT5_ENST00000343118.4_Missense_Mutation_p.T217S|B3GALT5_ENST00000398714.2_Missense_Mutation_p.T217S			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	217					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				TGCTCCGGCACCGGCTACGTG	0.512													33	38					0	0	1	0	0	G	41033136	C	G	41033136	3	3	11	1	0	0	0	0	1	0	0	0	1248	507	18	5	652	5	B3GALT5	21	41033136	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	21347784	41033136	7096759	73	792										
SLC5A1	6523	broad.mit.edu	37	chr22	32480588	32480588	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	cctcacgggagacctcccatGgcctgggttcatctttggga	12	13	3	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chr22:32480588G>T	ENST00000266088.4	+	8	1077	c.827G>T	c.(826-828)tGg>tTg	p.W276L	SLC5A1_ENST00000543737.1_Missense_Mutation_p.W149L	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	276					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						GACCTCCCATGGCCTGGGTTC	0.537													5	53					0.00116845	0.001261	1	1	0	T	32480588	G	T	32480588	3	4	11	1	0	0	0	0	1	0	0	0	14715	1357	47	5	857	5	SLC5A1	22	32480588	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08		32480588	18823978	74	793										
WDR13	64743	broad.mit.edu	37	chrX	48458098	48458098	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gtttttgaccagcacgtggaTgaggcaggtgagccagtggg	17	7	0	3			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:48458098T>A	ENST00000218056.5	+	4	1021	c.516T>A	c.(514-516)gaT>gaA	p.D172E	WDR13_ENST00000492715.1_3'UTR	NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	172						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						AGCACGTGGATGAGGCAGGTG	0.572													17	32					0	0	1	0	0	A	48458098	T	A	48458098	3	1	11	1	0	0	0	0	1	0	0	0	17334	1461	51	4	530	4	WDR13	23	48458098	Missense_Mutation	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08		48458098	106812462	75	794										
APEX2	27301	broad.mit.edu	37	chrX	55033376	55033379	+	Frame_Shift_Del	DEL	GACG	GACG	-													0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	agtcctgtgttggagcagtcGacgctgcagcacaacaatca							TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:55033376_55033379delGACG	ENST00000374987.3	+	6	1131_1134	c.1065_1068delGACG	c.(1063-1068)tcfs	p.ST355fs		NM_014481.2	NP_055296.2	Q9UBZ4	APEX2_HUMAN	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	355					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding	p.T356T(1)		breast(1)|endometrium(8)|large_intestine(4)|lung(6)|prostate(1)|urinary_tract(1)	21						TGGAGCAGTCGACGCTGCAGCACA	0.569								Other BER factors					14	52	---	---	---	---						-	55033379	GACG	-	55033376	7	5	11	1	0	1	0	1	0	0	0	0	766	1045	37	0	1087	0	APEX2	23	55033376	Frame_Shift_Del	DEL	GACG	TCGA-N5-A4RU-01A-31D-A28R-08	6575278	55033376	100237184	76	795										
MUM1L1	139221	broad.mit.edu	37	chrX	105451418	105451418	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	aggcagctgaagcaaagtatCtaaaaggaccatgtctaggc	11	8	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:105451418C>A	ENST00000337685.2	+	5	2778	c.1993C>A	c.(1993-1995)Cta>Ata	p.L665I	MUM1L1_ENST00000357175.2_Missense_Mutation_p.L665I|MUM1L1_ENST00000372552.1_Missense_Mutation_p.L665I	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	665										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						AGCAAAGTATCTAAAAGGACC	0.338													3	2					0.004672	0.00494416	1	1	0	A	105451418	C	A	105451418	3	1	11	1	0	0	0	0	1	0	0	0	10033	912	32	2	1995	2	MUM1L1	23	105451418	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	50418042	105451418	49819142	77	796										
GPC3	2719	broad.mit.edu	37	chrX	132888171	132888171	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	gaacatggcattggtgtagtTcttggcatggcgaacaacaa	12	7	1	0			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:132888171T>C	ENST00000370818.3	-	3	815	c.370A>G	c.(370-372)Aac>Gac	p.N124D	GPC3_ENST00000543339.1_Missense_Mutation_p.N70D|GPC3_ENST00000394299.2_Missense_Mutation_p.N124D	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	124						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					TTGGTGTAGTTCTTGGCATGG	0.368			"T, D, Mis, N, F, S"			Wilms tumour			Simpson-Golabi-Behmel syndrome				50	86					0	0	1	0	0	C	132888171	T	C	132888171	3	2	11	1	0	0	0	0	1	0	0	0	6638	1783	62	4	1469	4	GPC3	23	132888171	Missense_Mutation	SNP	T	TCGA-N5-A4RU-01A-31D-A28R-08	27436753	132888171	22382389	78	797										
PLXNA3	55558	broad.mit.edu	37	chrX	153692521	153692521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	tgaccgtcaccctgcacaacGtgccagacctcagtgcgggc	11	16	2	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:153692521G>A	ENST00000369682.3	+	8	1868	c.1693G>A	c.(1693-1695)Gtg>Atg	p.V565M		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	565					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGCACAACGTGCCAGACCT	0.697													24	16					0	0	1	0	0	A	153692521	G	A	153692521	3	1	11	1	0	0	0	0	1	0	0	0	12168	1145	40	1	1719	1	PLXNA3	23	153692521	Missense_Mutation	SNP	G	TCGA-N5-A4RU-01A-31D-A28R-08	20804350	153692521	1578039	79	798										
F8	2157	broad.mit.edu	37	chrX	154185347	154185347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	agtaatagcgggtcaggcacCgaggatctgatttagttggc	14	7	2	1			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:154185347C>T	ENST00000360256.4	-	11	1837	c.1637G>A	c.(1636-1638)cGg>cAg	p.R546Q		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	546	F5/8 type A 2.|Plastocyanin-like 3.		R -> W (in HEMA; mild; dbSNP:rs28937277).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGTCAGGCACCGAGGATCTGA	0.413													79	98					0	0	1	0	0	T	154185347	C	T	154185347	3	4	11	1	0	0	0	0	1	0	0	0	5378	652	23	1	5510	1	F8	23	154185347	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	492826	154185347	1085213	80	799										
BRCC3	79184	broad.mit.edu	37	chrX	154305493	154305493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0740740740740741	6	1	1.13860465116279	1.632	0.874285714285714	1	1	0	attctgtcatcatcttacgaCgttctgataagaggaaggac	9	8	5	2			TCGA-N5-A4RU-01A-31D-A28R-08	TCGA-N5-A4RU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	242dd42e-f133-49c1-be40-6a2705b818da	ecba6980-a54c-4260-a022-f43e92e84e79	g.chrX:154305493C>T	ENST00000369462.1	+	4	269	c.244C>T	c.(244-246)Cgt>Tgt	p.R82C	BRCC3_ENST00000369459.2_Missense_Mutation_p.R82C|BRCC3_ENST00000340647.4_Missense_Mutation_p.R83C|BRCC3_ENST00000330045.7_Missense_Mutation_p.R82C|BRCC3_ENST00000399042.1_Missense_Mutation_p.R82C|MTCP1_ENST00000362018.2_Intron	NM_024332.3	NP_077308.1	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	82					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|skin(1)	22	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CATCTTACGACGTTCTGATAA	0.413													49	39					0	0	1	0	0	T	154305493	C	T	154305493	3	4	11	1	0	0	0	0	1	0	0	0	1502	536	19	1	258	1	BRCC3	23	154305493	Missense_Mutation	SNP	C	TCGA-N5-A4RU-01A-31D-A28R-08	120146	154305493	965067	81	800										
ZZZ3	26009	broad.mit.edu	37	chr1	78044547	78044547	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tgaaatacttctgtactcggCtggcaacctaaggaaacatg	9	9	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:78044547C>A	ENST00000370801.3	-	11	2565	c.2090G>T	c.(2089-2091)aGc>aTc	p.S697I	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Missense_Mutation_p.S203I	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	697	HTH myb-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						CTGTACTCGGCTGGCAACCTA	0.343													5	10					1.23904e-05	1.35704e-05	1	1	0	A	78044547	C	A	78044547	3	1	12	1	0	0	0	0	1	0	0	0	18295	797	28	5	641	5	ZZZ3	1	78044547	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		78044547	171206074	1	801										
LPPR4	0	broad.mit.edu	37	chr1	99764627	99764627	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	attatgctctacagctctcaTtacagatatcatacagctgt	5	10	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:99764627T>A	ENST00000370185.3	+	4	1072	c.575T>A	c.(574-576)aTt>aAt	p.I192N	LPPR4_ENST00000457765.1_Missense_Mutation_p.I192N|LPPR4_ENST00000370184.1_Missense_Mutation_p.I34N	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		192							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ACAGCTCTCATTACAGATATC	0.368													11	16					0	0	1	0	0	A	99764627	T	A	99764627	3	1	12	1	0	0	0	0	1	0	0	0	8971	1493	52	4	589	4	LPPR4	1	99764627	Missense_Mutation	SNP	T	TCGA-N5-A4RV-01A-21D-A28R-08	21720080	99764627	149485994	2	802										
SEC22B	9554	broad.mit.edu	37	chr1	145109259	145109260	+	RNA	INS	-	-	A													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	atgccactgcactccagcccINSgggggcagagcgagactccg					rs61810755	by1000genomes	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:145109259_145109260insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										cactccagcccgggggcagagc	0.48													3	6	---	---	---	---						A	145109260	-	A	145109259	6	5	12	0	1	1	1	0	0	0	0	0	14042	667	23	0		0	SEC22B	1	145109259	RNA	INS	-	TCGA-N5-A4RV-01A-21D-A28R-08	45344632	145109259	104141362	3	803										
SETDB1	9869	broad.mit.edu	37	chr1	150921998	150921998	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	acctgggatcaaccagacatAtaggtgagaaaatctgaggc	11	8	2	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:150921998A>G	ENST00000271640.5	+	12	1767	c.1577A>G	c.(1576-1578)tAt>tGt	p.Y526C	SETDB1_ENST00000368969.4_Missense_Mutation_p.Y526C|SETDB1_ENST00000459773.1_Intron	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AACCAGACATATAGGTGAGAA	0.502													27	89					0	0	1	0	0	G	150921998	A	G	150921998	3	3	12	1	0	0	0	0	1	0	0	0	14191	449	16	4	1619	4	SETDB1	1	150921998	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	5812739	150921998	98328623	4	804										
C1orf43	25912	broad.mit.edu	37	chr1	154179938	154179939	+	Frame_Shift_Del	DEL	AC	AC	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cttcagctccgtcacagagtActctccaatgtgttatagtt							TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:154179938_154179939delAC	ENST00000368521.5	-	7	950_951	c.752_753delGT	c.(751-753)afs	p.S251fs	C1orf43_ENST00000350592.3_Frame_Shift_Del_p.S217fs|C1orf43_ENST00000368519.1_Frame_Shift_Del_p.S233fs|C1orf43_ENST00000483282.1_5'UTR|C1orf43_ENST00000362076.4_Frame_Shift_Del_p.S199fs	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	251						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					GTCACAGAGTACTCTCCAATGT	0.51													9	149	---	---	---	---						-	154179939	AC	-	154179938	7	5	12	1	0	1	0	1	0	0	0	0	2054	388	14	0	12	0	C1orf43	1	154179938	Frame_Shift_Del	DEL	AC	TCGA-N5-A4RV-01A-21D-A28R-08	3257940	154179938	95070683	5	805										
C1orf74	148304	broad.mit.edu	37	chr1	209956665	209956665	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	atggtaccaagcagcacctgCtccaagtgctgacatacatg	9	12	0	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:209956665C>G	ENST00000294811.1	-	2	571	c.315G>C	c.(313-315)gaG>gaC	p.E105D		NM_152485.2	NP_689698.1	Q96LT6	CA074_HUMAN	chromosome 1 open reading frame 74	105										endometrium(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	15				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		GCAGCACCTGCTCCAAGTGCT	0.532													16	45					0	0	1	0	0	G	209956665	C	G	209956665	3	3	12	1	0	0	0	0	1	0	0	0	2072	796	28	5	498	5	C1orf74	1	209956665	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	55776727	209956665	39293956	6	806										
RD3	343035	broad.mit.edu	37	chr1	211652494	211652494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gctggcgaagggcgagatgcGcgcgcgggtcttgaaggtgg	21	8	1	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:211652494G>A	ENST00000367002.4	-	3	1635	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C	RD3_ENST00000484910.1_5'UTR	NM_001164688.1|NM_183059.2	NP_001158160.1|NP_898882.1	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	158					response to stimulus|visual perception					central_nervous_system(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GGCGAGATGCGCGCGCGGGTC	0.692													9	31					0	0	1	0	0	A	211652494	G	A	211652494	3	1	12	1	0	0	0	0	1	0	0	0	13238	1087	38	1	119	1	RD3	1	211652494	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	1695829	211652494	37598127	7	807										
MXD1	4084	broad.mit.edu	37	chr2	70165331	70165331	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cgagcggggcagcatgcagaGcctcggcagtgatgagggct	18	10	0	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:70165331G>C	ENST00000264444.2	+	6	841	c.581G>C	c.(580-582)aGc>aCc	p.S194T	MXD1_ENST00000540449.1_Missense_Mutation_p.S184T|MXD1_ENST00000465446.1_3'UTR	NM_001202513.1|NM_001202514.1|NM_002357.3	NP_001189442.1|NP_001189443.1|NP_002348.1	Q05195	MAD1_HUMAN	MAX dimerization protein 1	194					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						AGCATGCAGAGCCTCGGCAGT	0.562													33	77					0	0	1	0	0	C	70165331	G	C	70165331	3	2	12	1	0	0	0	0	1	0	0	0	10046	971	34	5	603	5	MXD1	2	70165331	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08		70165331	173034042	8	808										
LRP1B	53353	broad.mit.edu	37	chr2	141108430	141108430	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ttttgtagaaaattccgcctGgattaaactgagtactccaa	7	8	0	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:141108430G>A	ENST00000389484.3	-	77	12799	c.11828C>T	c.(11827-11829)cCa>cTa	p.P3943L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3943					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATTCCGCCTGGATTAAACTG	0.328										TSP Lung(27;0.18)			31	16					0	0	1	0	0	A	141108430	G	A	141108430	3	1	12	1	0	0	0	0	1	0	0	0	8999	1348	47	3	2031	3	LRP1B	2	141108430	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	70943099	141108430	102090943	9	809										
FMNL2	114793	broad.mit.edu	37	chr2	153415331	153415331	+	Frame_Shift_Del	DEL	C	C	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tctctcatttgcacagtacgCggtaacgtaagtaaaacttg							TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:153415331delC	ENST00000288670.9	+	5	804	c.437delC	c.(436-438)ggfs	p.A146fs		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	146	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GCACAGTACGCGGTAACGTAA	0.378													6	13	---	---	---	---						-	153415331	C	-	153415331	7	5	12	1	0	1	0	1	0	0	0	0	5984	768	27	0	455	0	FMNL2	2	153415331	Frame_Shift_Del	DEL	C	TCGA-N5-A4RV-01A-21D-A28R-08	12306901	153415331	89784042	10	810										
DPP4	1803	broad.mit.edu	37	chr2	162865080	162865089	+	Frame_Shift_Del	DEL	TCCCACCGGG	TCCCACCGGG	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gcaattacataccatagtacTcccaccgggatacaggcgcc					rs138430103	by1000genomes	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:162865080_162865089delTCCCACCGGG	ENST00000360534.3	-	22	2530_2539	c.1970_1979delCCCGGTGGGA	c.(1969-1980)tgfs	p.SRWE657fs	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	657					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	ACCATAGTACTCCCACCGGGATACAGGCGC	0.471													24	19	---	---	---	---						-	162865089	TCCCACCGGG	-	162865080	7	5	12	1	0	1	0	1	0	0	0	0	4755	1551	54	0	341	0	DPP4	2	162865080	Frame_Shift_Del	DEL	TCCCACCGGG	TCGA-N5-A4RV-01A-21D-A28R-08	9449749	162865080	80334293	11	811										
KIF1A	547	broad.mit.edu	37	chr2	241713633	241713633	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gggtctcatcgtagttgatgTctgcaggactcaaggctgcc	13	10	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:241713633T>A	ENST00000498729.2	-	12	1250	c.1004A>T	c.(1003-1005)gAc>gTc	p.D335V	KIF1A_ENST00000320389.7_Missense_Mutation_p.D335V	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	335	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GTAGTTGATGTCTGCAGGACT	0.587													27	8					0	0	1	0	0	A	241713633	T	A	241713633	3	1	12	1	0	0	0	0	1	0	0	0	8324	1667	58	4	4212	4	KIF1A	2	241713633	Missense_Mutation	SNP	T	TCGA-N5-A4RV-01A-21D-A28R-08	78848553	241713633	1485740	12	812										
MYRIP	25924	broad.mit.edu	37	chr3	40231702	40231702	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gaagttgggcaccaggccagActgtcctggttgcagaggaa	15	9	0	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:40231702A>G	ENST00000302541.6	+	10	1755	c.1413A>G	c.(1411-1413)agA>agG	p.R471R	MYRIP_ENST00000396217.3_Silent_p.R382R|MYRIP_ENST00000539167.1_Silent_p.R284R|MYRIP_ENST00000425621.1_Silent_p.R471R|MYRIP_ENST00000444716.1_Silent_p.R471R|MYRIP_ENST00000459828.1_3'UTR	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	471	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		ACCAGGCCAGACTGTCCTGGT	0.622													32	60					0	0	1	0	0	G	40231702	A	G	40231702	2	3	12	1	0	0	0	0	0	0	0	1	10147	272	10	4		4	MYRIP	3	40231702	Silent	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08		40231702	157790728	13	813										
DNAH1	25981	broad.mit.edu	37	chr3	52431061	52431061	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cgcctacctacgacctccacGtgagtccagcccaaagggct	9	17	0	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:52431061G>A	ENST00000420323.2	+	73	12048		c.e73+1			NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1						ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGACCTCCACGTGAGTCCAGC	0.632													6	10					0	0	1	0	0	A	52431061	G	A	52431061	5	1	12	1	0	0	0	0	0	0	1	0	4625	1159	40	1	12074	1	DNAH1	3	52431061	Splice_Site	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	12199359	52431061	145591369	14	814										
SLCO2A1	6578	broad.mit.edu	37	chr3	133664065	133664065	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tctgggcacgagcagtccctGcggcaggcaggagactgcgg	17	12	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:133664065G>T	ENST00000310926.4	-	10	1608	c.1335C>A	c.(1333-1335)cgC>cgA	p.R445R	SLCO2A1_ENST00000493729.1_Silent_p.R369R	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	445	Kazal-like.				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						AGCAGTCCCTGCGGCAGGCAG	0.522													56	305					5.73376e-24	6.59382e-24	1	1	0	T	133664065	G	T	133664065	2	4	12	1	0	0	0	0	0	0	0	1	14780	1306	46	5		5	SLCO2A1	3	133664065	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	81233004	133664065	64358365	15	815										
MED12L	116931	broad.mit.edu	37	chr3	150877759	150877760	+	Frame_Shift_Ins	INS	-	-	TCGAGTA													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tgatgataggaccaaacaacINStcgagtatcggggcccccag							TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:150877759_150877760insTCGAGTA	ENST00000474524.1	+	7	1016_1017	c.978_979insTCGAGTA	c.(976-981)aacgagfs	p.E327fs	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000422248.2_Frame_Shift_Ins_p.E327fs|MED12L_ENST00000309237.4_Frame_Shift_Ins_p.E327fs	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	327					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GACCAAACAACTCGAGTATCGG	0.609													7	205	---	---	---	---						TCGAGTA	150877760	-	TCGAGTA	150877759	7	5	12	1	0	1	1	0	0	0	0	0	9478	564	20	0	1004	0	MED12L	3	150877759	Frame_Shift_Ins	INS	-	TCGA-N5-A4RV-01A-21D-A28R-08	17213694	150877759	47144671	16	816										
SI	6476	broad.mit.edu	37	chr3	164704992	164704992	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	attatcatctgcagcaacaaTgagcttcatgtgtttttgtc	7	8	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:164704992T>G	ENST00000264382.3	-	45	5193	c.5131A>C	c.(5131-5133)Att>Ctt	p.I1711L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1711	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCAGCAACAATGAGCTTCATG	0.343										HNSCC(35;0.089)			12	29					0	0	1	0	0	G	164704992	T	G	164704992	3	3	12	1	0	0	0	0	1	0	0	0	14351	1464	51	4	368	4	SI	3	164704992	Missense_Mutation	SNP	T	TCGA-N5-A4RV-01A-21D-A28R-08	13827233	164704992	33317438	17	817										
SLITRK3	22865	broad.mit.edu	37	chr3	164908297	164908297	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ctgcaatgcattgttcccaaGattaatagacacagcattat	6	9	0	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:164908297G>T	ENST00000475390.1	-	2	765	c.322C>A	c.(322-324)Ctt>Att	p.L108I	SLITRK3_ENST00000241274.3_Missense_Mutation_p.L108I			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	108						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TTGTTCCCAAGATTAATAGAC	0.343										HNSCC(40;0.11)			23	10					1.22574e-08	1.35865e-08	1	1	0	T	164908297	G	T	164908297	3	4	12	1	0	0	0	0	1	0	0	0	14797	942	33	2	2615	2	SLITRK3	3	164908297	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	203305	164908297	33114133	18	818										
MFI2	4241	broad.mit.edu	37	chr3	196736583	196736583	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gcagggctgccgaaaccggcGtggcaggagcgcttgccccg	17	14	0	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:196736583G>A	ENST00000296350.5	-	11	1544	c.1431C>T	c.(1429-1431)caC>caT	p.H477H		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	477	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CGAAACCGGCGTGGCAGGAGC	0.637													51	28					0	0	1	0	0	A	196736583	G	A	196736583	2	1	12	1	0	0	0	0	0	0	0	1	9571	1136	40	1		1	MFI2	3	196736583	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	31828286	196736583	1285847	19	819										
TMEM144	55314	broad.mit.edu	37	chr4	159140504	159140504	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gcagaagaagtatcaaatccGctgctaaattacattggagc	9	8	1	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr4:159140504G>A	ENST00000514558.1	+	5	2171	c.375G>A	c.(373-375)ccG>ccA	p.P125P	TMEM144_ENST00000296529.6_Silent_p.P125P			Q7Z5S9	TM144_HUMAN	transmembrane protein 144	125						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(7)|lung(9)|prostate(1)	19	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		TATCAAATCCGCTGCTAAATT	0.363													31	74					0	0	1	0	0	A	159140504	G	A	159140504	2	1	12	1	0	0	0	0	0	0	0	1	16117	1074	38	1		1	TMEM144	4	159140504	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08		159140504	32013772	20	820										
C5orf51	285636	broad.mit.edu	37	chr5	41904475	41904475	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ccgccgattgtggccatggcGgccgcagtctctagtgtggt	15	12	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:41904475G>C	ENST00000381647.2	+	1	25	c.6G>C	c.(4-6)gcG>gcC	p.A2A	C5orf51_ENST00000505931.2_Intron	NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	2										endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TGGCCATGGCGGCCGCAGTCT	0.662													14	21					0	0	1	0	0	C	41904475	G	C	41904475	2	2	12	1	0	0	0	0	0	0	0	1	2323	1103	39	5		5	C5orf51	5	41904475	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08		41904475	139010785	21	821										
IL6ST	3572	broad.mit.edu	37	chr5	55265552	55265552	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	aaaatggtttgttttccagaCaatgtaattagcatttacat	6	5	0	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:55265552C>T	ENST00000381298.2	-	4	508	c.196G>A	c.(196-198)Gtc>Atc	p.V66I	IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000536319.1_Missense_Mutation_p.V66I|IL6ST_ENST00000502326.3_Missense_Mutation_p.V66I|IL6ST_ENST00000522633.2_Missense_Mutation_p.V66I|IL6ST_ENST00000577363.1_Intron|IL6ST_ENST00000336909.5_Missense_Mutation_p.V66I|IL6ST_ENST00000381294.3_Missense_Mutation_p.V66I|IL6ST_ENST00000381287.4_Missense_Mutation_p.V66I|IL6ST_ENST00000396816.1_Intron|IL6ST_ENST00000381286.3_Intron	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	66	Ig-like C2-type.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				GTTTTCCAGACAATGTAATTA	0.318			O		hepatocellular ca								13	35					0	0	1	0	0	T	55265552	C	T	55265552	3	4	12	1	0	0	0	0	1	0	0	0	7746	478	17	3	2616	3	IL6ST	5	55265552	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	13361077	55265552	125649708	22	822										
F2RL1	2150	broad.mit.edu	37	chr5	76115089	76115089	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cctgcagtggcaccatccaaGgtgagaaacctggccaagga	12	12	0	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:76115089G>T	ENST00000296677.4	+	1	288	c.82_splice	c.e1+1	p.G28_splice		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	28					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		CACCATCCAAGGTGAGAAACC	0.672													4	7					0.014758	0.0149202	1	1	0	T	76115089	G	T	76115089	5	4	12	1	0	0	0	0	0	0	1	0	5372	1014	35	5	84	5	F2RL1	5	76115089	Splice_Site	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	20849537	76115089	104800171	23	823										
ANXA6	309	broad.mit.edu	37	chr5	150512081	150512081	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	agtccccagacagctcccctCggatgctggcttcaatcggc	10	16	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:150512081C>G	ENST00000354546.5	-	10	919	c.692G>C	c.(691-693)cGa>cCa	p.R231P	ANXA6_ENST00000523714.1_Missense_Mutation_p.R199P|ANXA6_ENST00000356496.5_Missense_Mutation_p.R231P|ANXA6_ENST00000521512.1_Intron|ANXA6_ENST00000377751.5_Intron	NM_001155.4	NP_001146.2	P08133	ANXA6_HUMAN	annexin A6	231						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding	p.R231Q(1)		endometrium(2)|kidney(1)|lung(9)	12		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCTCCCCTCGGATGCTGGC	0.552													9	19					0	0	1	0	0	G	150512081	C	G	150512081	3	3	12	1	0	0	0	0	1	0	0	0	716	884	31	2	1397	2	ANXA6	5	150512081	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	74396992	150512081	30403179	24	824										
EHMT2	10919	broad.mit.edu	37	chr6	31848029	31848029	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ttgatgtcccagaagcggtcGccatagtcaaacctgtcaga	10	11	2	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:31848029G>A	ENST00000395728.3	-	27	3635	c.3636C>T	c.(3634-3636)ggC>ggT	p.G1212G	EHMT2_ENST00000375528.4_Silent_p.G1178G|EHMT2_ENST00000375530.4_Silent_p.G1121G|EHMT2_ENST00000375537.4_Silent_p.G1155G|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1155					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						AGAAGCGGTCGCCATAGTCAA	0.567													4	37					0	0	1	0	0	A	31848029	G	A	31848029	2	1	12	1	0	0	0	0	0	0	0	1	5010	1074	38	1		1	EHMT2	6	31848029	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08		31848029	139267038	25	825										
TREML2	79865	broad.mit.edu	37	chr6	41162265	41162265	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ggtccccagacttagtggagAtggattctgggccagcagag	15	9	1	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:41162265A>C	ENST00000483722.1	-	3	868	c.683T>G	c.(682-684)aTc>aGc	p.I228S		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	228					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTTAGTGGAGATGGATTCTGG	0.622													21	18					0	0	1	0	0	C	41162265	A	C	41162265	3	2	12	1	0	0	0	0	1	0	0	0	16533	333	12	4	294	4	TREML2	6	41162265	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	9314236	41162265	129952802	26	826										
PRDM1	639	broad.mit.edu	37	chr6	106552814	106552814	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cctaaaattggactccaaccCctccaaaggaaaggacctct	6	14	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:106552814C>A	ENST00000369096.4	+	5	1013	c.779C>A	c.(778-780)cCc>cAc	p.P260H	PRDM1_ENST00000369091.2_Missense_Mutation_p.P224H|PRDM1_ENST00000369089.3_Missense_Mutation_p.P126H	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	260					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GACTCCAACCCCTCCAAAGGA	0.468			"D, N, Mis, F, S"		DLBCL								201	223					7.15978e-92	8.33798e-92	1	1	0	A	106552814	C	A	106552814	3	1	12	1	0	0	0	0	1	0	0	0	12501	623	22	5	810	5	PRDM1	6	106552814	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	65390549	106552814	64562253	27	827										
STX7	8417	broad.mit.edu	37	chr6	132792624	132792624	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	acactctggaactggctcttActcgagcaacaaactctttc	6	13	3	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:132792624A>C	ENST00000367941.2	-	5	478	c.365T>G	c.(364-366)gTa>gGa	p.V122G	STX7_ENST00000448348.3_5'UTR|STX7_ENST00000367937.4_Missense_Mutation_p.V122G	NM_003569.2	NP_003560.2	O15400	STX7_HUMAN	syntaxin 7	122					intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(1)|lung(5)	19	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ACTGGCTCTTACTCGAGCAAC	0.428													38	55					0	0	1	0	0	C	132792624	A	C	132792624	3	2	12	1	0	0	0	0	1	0	0	0	15405	391	14	4	444	4	STX7	6	132792624	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	26239810	132792624	38322443	28	828										
IGF2R	3482	broad.mit.edu	37	chr6	160517488	160517488	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cagacggcgatctcgatgtcGtgtttgcctcttcctctaag	10	12	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:160517488G>C	ENST00000356956.1	+	45	6821	c.6673G>C	c.(6673-6675)Gtg>Ctg	p.V2225L	IGF2R_ENST00000475584.1_3'UTR	NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	2225					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity	p.V2225M(1)		breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TCTCGATGTCGTGTTTGCCTC	0.512													19	196					0	0	1	0	0	C	160517488	G	C	160517488	3	2	12	1	0	0	0	0	1	0	0	0	7619	1145	40	5	6851	5	IGF2R	6	160517488	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	27724864	160517488	10597579	29	829										
TNRC18	84629	broad.mit.edu	37	chr7	5352561	5352563	+	In_Frame_Del	DEL	GAG	GAG	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	aggaggatgaggacgaggaaGaggaggaggaggaagaggag							TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:5352561_5352563delGAG	ENST00000399537.4	-	27	8307_8309	c.7959_7961delCTC	c.(7957-7962)tct>tc	p.SS2669del	TNRC18_ENST00000430969.1_In_Frame_Del_p.SS2669del			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2669	Ser-rich.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ggacgaggaagaggaggaggagg	0.606													2	4	---	---	---	---						-	5352563	GAG	-	5352561	7	5	12	1	0	1	0	1	0	0	0	0	16398	942	33	0	961	0	TNRC18	7	5352561	In_Frame_Del	DEL	GAG	TCGA-N5-A4RV-01A-21D-A28R-08		5352561	153786102	30	830										
LMOD2	442721	broad.mit.edu	37	chr7	123302950	123302950	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tccccctccttcttcccaaaGgctgccaccacctcctcctc	3	23	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:123302950G>T	ENST00000458573.2	+	2	1467	c.1310G>T	c.(1309-1311)aGg>aTg	p.R437M	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	437	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding										tcttcccaaaggctgccacca	0.572													7	2					8.12818e-05	8.59532e-05	1	1	0	T	123302950	G	T	123302950	3	4	12	1	0	0	0	0	1	0	0	0	8897	1000	35	5	1316	5	LMOD2	7	123302950	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	117950389	123302950	35835713	31	831										
OR2A12	346525	broad.mit.edu	37	chr7	143792722	143792722	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tgtggcccacaaaagatcaaCcactttttctgtcaaatcat	5	11	4	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:143792722C>T	ENST00000408949.2	+	1	582	c.522C>T	c.(520-522)aaC>aaT	p.N174N		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AAAAGATCAACCACTTTTTCT	0.463													33	72					0	0	1	0	0	T	143792722	C	T	143792722	2	4	12	1	0	0	0	0	0	0	0	1	11022	506	18	3		3	OR2A12	7	143792722	Silent	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	20489772	143792722	15345941	32	832										
ATG9B	285973	broad.mit.edu	37	chr7	150715385	150715385	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tcgcgcccaccctcaccgctCggtactgcagcagctgcgcc	10	20	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:150715385C>T	ENST00000605938.1	-	7	1943	c.1868G>A	c.(1867-1869)cGa>cAa	p.R623Q	ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000377974.2_Missense_Mutation_p.R623Q|ATG9B_ENST00000444312.1_Missense_Mutation_p.R109Q	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	623					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCACCGCTCGGTACTGCAG	0.711											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	27					0	0	1	0	0	T	150715385	C	T	150715385	3	4	12	1	0	0	0	0	1	0	0	0	1102	884	31	1	933	1	ATG9B	7	150715385	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	6922663	150715385	8423278	33	833										
MSC	9242	broad.mit.edu	37	chr8	72756427	72756427	+	Translation_Start_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tggacatcccgttgtcccccTtgcccacacgcgtcctcttt	7	18	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:72756427T>A	ENST00000325509.4	-	0	276				RP11-383H13.1_ENST00000457356.4_3'UTR|RP11-383H13.1_ENST00000521467.1_Intron|RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron	NM_005098.3	NP_005089.2	O60682	MUSC_HUMAN	musculin						transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(4)|skin(2)	26	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			GTTGTCCCCCTTGCCCACACG	0.692													29	17					0	0	1	0	0	A	72756427	T	A	72756427	1	1	12	1	0	0	0	0	0	0	0	0	9916	1624	56	4		4	MSC	8	72756427	Translation_Start_Site	SNP	T	TCGA-N5-A4RV-01A-21D-A28R-08		72756427	73607595	34	834										
CSMD3	114788	broad.mit.edu	37	chr8	113358408	113358408	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	aacccaggactgaggatcacAccactgaagtctgacatagc	9	12	2	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:113358408A>C	ENST00000297405.5	-	41	6604	c.6360T>G	c.(6358-6360)ggT>ggG	p.G2120G	CSMD3_ENST00000455883.2_Silent_p.G2016G|CSMD3_ENST00000352409.3_Silent_p.G2050G|CSMD3_ENST00000343508.3_Silent_p.G2080G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2120	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGAGGATCACACCACTGAAGT	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			71	48					0	0	1	0	0	C	113358408	A	C	113358408	2	2	12	1	0	0	0	0	0	0	0	1	3971	146	6	4		4	CSMD3	8	113358408	Silent	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	40601981	113358408	33005614	35	835										
CSMD3	114788	broad.mit.edu	37	chr8	113585824	113585824	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gtactactaagtgtcagtccGcgcatagatgcaccagtaaa	9	10	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:113585824G>A	ENST00000297405.5	-	24	4192	c.3948C>T	c.(3946-3948)cgC>cgT	p.R1316R	CSMD3_ENST00000455883.2_Silent_p.R1212R|CSMD3_ENST00000352409.3_Silent_p.R1316R|CSMD3_ENST00000343508.3_Silent_p.R1276R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1316	CUB 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTGTCAGTCCGCGCATAGATG	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	143					0	0	1	0	0	A	113585824	G	A	113585824	2	1	12	1	0	0	0	0	0	0	0	1	3971	1074	38	1		1	CSMD3	8	113585824	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	227416	113585824	32778198	36	836										
C8orf76	84933	broad.mit.edu	37	chr8	124250155	124250155	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gttgatgacaatttttcagaGatactggaatactcctgcag	9	7	1	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:124250155G>T	ENST00000276704.4	-	3	291	c.240C>A	c.(238-240)atC>atA	p.I80I	ZHX1-C8ORF76_ENST00000357082.4_Silent_p.I48I|C8orf76_ENST00000521310.1_5'UTR	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	80							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTTTCAGAGATACTGGAAT	0.423													34	45					3.11337e-16	3.49305e-16	1	1	0	T	124250155	G	T	124250155	2	4	12	1	0	0	0	0	0	0	0	1	2455	932	33	2		2	C8orf76	8	124250155	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	10664331	124250155	22113867	37	837										
DIRAS2	0	broad.mit.edu	37	chr9	93375839	93375839	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gagctcctccaaggactgtcGgctggtaatggagtacacca	12	11	0	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr9:93375839G>A	ENST00000375765.3	-	2	659	c.271C>T	c.(271-273)Cga>Tga	p.R91*		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	91					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						AAGGACTGTCGGCTGGTAATG	0.582													86	4					0	0	1	0	0	A	93375839	G	A	93375839	4	1	12	1	0	0	0	0	0	1	0	0	4559	1124	39	1	332	1	DIRAS2	9	93375839	Nonsense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08		93375839	47837592	38	838										
NOTCH1	4851	broad.mit.edu	37	chr9	139400313	139400313	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	caggtacgagcgtcattctcAcacgtggcgccctcgaagcc	11	15	2	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr9:139400313A>T	ENST00000277541.6	-	25	4110	c.4035T>A	c.(4033-4035)tgT>tgA	p.C1345*		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1345	EGF-like 34.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTCATTCTCACACGTGGCGC	0.726			"T, Mis, O"	TRB@	T-ALL					HNSCC(8;0.001)			9	2					0	0	1	0	0	T	139400313	A	T	139400313	4	4	12	1	0	0	0	0	0	1	0	0	10593	157	6	4	3672	4	NOTCH1	9	139400313	Nonsense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	46024474	139400313	1813118	39	839										
SCD	6319	broad.mit.edu	37	chr10	102108089	102108089	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gattcctacctgcaagttctAcacctggctttggggtaagc	10	11	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr10:102108089A>T	ENST00000370355.2	+	2	677	c.296A>T	c.(295-297)tAc>tTc	p.Y99F		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	99					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TGCAAGTTCTACACCTGGCTT	0.493													95	68					0	0	1	0	0	T	102108089	A	T	102108089	3	4	12	1	0	0	0	0	1	0	0	0	13938	391	14	4	302	4	SCD	10	102108089	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08		102108089	33426658	40	840										
GPR137	56834	broad.mit.edu	37	chr11	64056826	64056826	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cctgtcatagtgagcttgtgCcgtccccctaggatgggggg	15	11	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:64056826C>T	ENST00000411458.1	+	9	1445	c.1417C>T	c.(1417-1419)Ccg>Tcg	p.P473S	GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000313074.3_Missense_Mutation_p.P415S|GPR137_ENST00000377702.4_3'UTR	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	415						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TGAGCTTGTGCCGTCCCCCTA	0.647													5	98					0	0	1	0	0	T	64056826	C	T	64056826	3	4	12	1	0	0	0	0	1	0	0	0	6684	739	26	3	1557	3	GPR137	11	64056826	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		64056826	70949690	41	841										
CCDC88B	283234	broad.mit.edu	37	chr11	64111265	64111265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ctcagcacccctagcaggagCggccccctcgctgcaagatg	11	17	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:64111265C>T	ENST00000356786.5	+	13	1378	c.1334C>T	c.(1333-1335)gCg>gTg	p.A445V	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	445					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTAGCAGGAGCGGCCCCCTCG	0.637													6	10					0	0	1	0	0	T	64111265	C	T	64111265	3	4	12	1	0	0	0	0	1	0	0	0	2884	768	27	1	1384	1	CCDC88B	11	64111265	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	54439	64111265	70895251	42	842										
CATSPER1	117144	broad.mit.edu	37	chr11	65784607	65784607	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gctgctcctgctccacgcttGccaccagctgcaggtaatgg	11	15	0	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:65784607G>T	ENST00000312106.5	-	11	2377	c.2240C>A	c.(2239-2241)gCa>gAa	p.A747E		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	747					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CTCCACGCTTGCCACCAGCTG	0.642													13	16					0.00185496	0.00189618	1	1	0	T	65784607	G	T	65784607	3	4	12	1	0	0	0	0	1	0	0	0	2705	1319	46	5	110	5	CATSPER1	11	65784607	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	1673342	65784607	69221909	43	843										
DYNC2H1	79659	broad.mit.edu	37	chr11	103182702	103182702	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	aatacacatcgagctcatgcTctcttcagtcttgcatggtt	7	11	4	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:103182702T>C	ENST00000375735.2	+	79	11733	c.11589T>C	c.(11587-11589)gcT>gcC	p.A3863A	DYNC2H1_ENST00000398093.3_Silent_p.A3870A|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3863	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GAGCTCATGCTCTCTTCAGTC	0.363													45	4					0	0	1	0	0	C	103182702	T	C	103182702	2	2	12	1	0	0	0	0	0	0	0	1	4872	1538	54	4		4	DYNC2H1	11	103182702	Silent	SNP	T	TCGA-N5-A4RV-01A-21D-A28R-08	37398095	103182702	31823814	44	844										
PDZD3	79849	broad.mit.edu	37	chr11	119057301	119057301	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ctgggcatgtggtgtgcaggGtggacccaggcacctctgcc	16	12	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:119057301G>A	ENST00000531114.1	+	2	979	c.430G>A	c.(430-432)Gtg>Atg	p.V144M	PDZD3_ENST00000355547.5_Missense_Mutation_p.V78M|PDZD3_ENST00000322712.4_Missense_Mutation_p.V78M|PDZD3_ENST00000525131.1_Missense_Mutation_p.V65M|PDZD3_ENST00000392817.2_Missense_Mutation_p.V144M			Q86UT5	NHRF4_HUMAN	PDZ domain containing 3	144	PDZ 1.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	14	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		GGTGTGCAGGGTGGACCCAGG	0.597													45	1					0	0	1	0	0	A	119057301	G	A	119057301	3	1	12	1	0	0	0	0	1	0	0	0	11748	1261	44	3	246	3	PDZD3	11	119057301	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	15874599	119057301	15949215	45	845										
CHD4	1108	broad.mit.edu	37	chr12	6700933	6700933	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tctgcagcagcaataatttcCcagatgctctgattagggca	9	10	2	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr12:6700933C>T	ENST00000309577.6	-	21	3312	c.3149G>A	c.(3148-3150)gGg>gAg	p.G1050E	CHD4_ENST00000357008.2_Missense_Mutation_p.G1050E|CHD4_ENST00000544484.1_Missense_Mutation_p.G1047E|CHD4_ENST00000544040.1_Missense_Mutation_p.G1043E			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1050					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CAATAATTTCCCAGATGCTCT	0.443													65	3					0	0	1	0	0	T	6700933	C	T	6700933	3	4	12	1	0	0	0	0	1	0	0	0	3349	623	22	3	2669	3	CHD4	12	6700933	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		6700933	127150962	46	846										
ACACB	32	broad.mit.edu	37	chr12	109696795	109696795	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cagataattcagcaggcaggAcaggtgtggttcccagactc	12	10	1	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr12:109696795A>G	ENST00000338432.7	+	47	6497	c.6378A>G	c.(6376-6378)ggA>ggG	p.G2126G	ACACB_ENST00000377854.5_Silent_p.G2056G|ACACB_ENST00000543201.1_Silent_p.G792G|ACACB_ENST00000377848.3_Silent_p.G2126G			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2126	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGCAGGCAGGACAGGTGTGGT	0.577											OREG0007682	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=ACACB|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	44	188					0	0	1	0	0	G	109696795	A	G	109696795	2	3	12	1	0	0	0	0	0	0	0	1	107	262	10	4		4	ACACB	12	109696795	Silent	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	102995862	109696795	24155100	47	847										
RB1	5925	broad.mit.edu	37	chr13	49033926	49033926	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gacccttttccagcacacccTgcagaatgagtatgaactca	7	13	1	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr13:49033926T>G	ENST00000267163.4	+	20	2201	c.2063T>G	c.(2062-2064)cTg>cGg	p.L688R		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	688	Domain B.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)|p.L688P(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGCACACCCTGCAGAATGAG	0.443		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			34	1					0	0	1	0	0	G	49033926	T	G	49033926	3	3	12	1	0	0	0	0	1	0	0	0	13149	1580	55	4	2141	4	RB1	13	49033926	Missense_Mutation	SNP	T	TCGA-N5-A4RV-01A-21D-A28R-08		49033926	66135952	48	848										
CAPN3	825	broad.mit.edu	37	chr15	42693949	42693949	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tggccctgatgcagaagaacCggcggaaggaccggaagcta	15	10	0	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr15:42693949C>G	ENST00000397163.3	+	11	1684	c.1465C>G	c.(1465-1467)Cgg>Ggg	p.R489G	CAPN3_ENST00000357568.3_Missense_Mutation_p.R489G|CAPN3_ENST00000349748.3_Missense_Mutation_p.R441G|CAPN3_ENST00000356316.3_Missense_Mutation_p.R402G|CAPN3_ENST00000318023.7_Missense_Mutation_p.R489G|RP11-164J13.1_ENST00000495723.1_RNA	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	489	Domain III.		R -> Q (in LGMD2A).|R -> W (in LGMD2A).		muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GCAGAAGAACCGGCGGAAGGA	0.572													10	39					0	0	1	0	0	G	42693949	C	G	42693949	3	3	12	1	0	0	0	0	1	0	0	0	2646	643	23	5	1559	5	CAPN3	15	42693949	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		42693949	59837443	49	849										
UACA	55075	broad.mit.edu	37	chr15	70959158	70959158	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cttatcacatcgttccttctGatccttaatttcttgctcaa	3	12	4	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr15:70959158G>C	ENST00000322954.6	-	16	4050	c.3865C>G	c.(3865-3867)Cag>Gag	p.Q1289E	UACA_ENST00000560441.1_Missense_Mutation_p.Q1274E|UACA_ENST00000379983.2_Missense_Mutation_p.Q1276E|UACA_ENST00000539319.1_Missense_Mutation_p.Q1180E	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	1289						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						CGTTCCTTCTGATCCTTAATT	0.348													7	50					0	0	1	0	0	C	70959158	G	C	70959158	3	2	12	1	0	0	0	0	1	0	0	0	16884	1299	45	2	401	2	UACA	15	70959158	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	28265209	70959158	31572234	50	850										
KIAA0895L	653319	broad.mit.edu	37	chr16	67214278	67214278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cagagtaggtgctctcactgCgacgcatgtggccacggtgg	15	11	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr16:67214278C>T	ENST00000290881.7	-	3	1162	c.236G>A	c.(235-237)cGc>cAc	p.R79H	KIAA0895L_ENST00000563902.1_Missense_Mutation_p.R79H|KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000561621.1_Missense_Mutation_p.R79H			Q68EN5	K895L_HUMAN	KIAA0895-like	79										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						GCTCTCACTGCGACGCATGTG	0.692													7	6					0	0	1	0	0	T	67214278	C	T	67214278	3	4	12	1	0	0	0	0	1	0	0	0	8239	768	27	1	1203	1	KIAA0895L	16	67214278	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		67214278	23140475	51	851										
CNTNAP4	85445	broad.mit.edu	37	chr16	76555943	76555943	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gtaatatttccagctccgacAgtagtgactttttcatttga	7	8	1	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr16:76555943A>T	ENST00000307431.8	+	18	2926	c.2541A>T	c.(2539-2541)acA>acT	p.T847T	CNTNAP4_ENST00000377504.4_Silent_p.T799T|CNTNAP4_ENST00000478060.1_Silent_p.T775T|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Silent_p.T851T	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	848	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CAGCTCCGACAGTAGTGACTT	0.453													47	103					0	0	1	0	0	T	76555943	A	T	76555943	2	4	12	1	0	0	0	0	0	0	0	1	3672	175	7	4		4	CNTNAP4	16	76555943	Silent	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	9341665	76555943	13798810	52	852										
USP10	9100	broad.mit.edu	37	chr16	84792334	84792334	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tctttcagagttgctggagaAtgtaaccctaatccataaac	7	9	2	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr16:84792334A>G	ENST00000219473.7	+	5	1318	c.1205A>G	c.(1204-1206)aAt>aGt	p.N402S	USP10_ENST00000570191.1_Missense_Mutation_p.N406S	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	402					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						TTGCTGGAGAATGTAACCCTA	0.438													24	52					0	0	1	0	0	G	84792334	A	G	84792334	3	3	12	1	0	0	0	0	1	0	0	0	17100	101	4	4	1223	4	USP10	16	84792334	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	8236391	84792334	5562419	53	853										
TP53	7157	broad.mit.edu	37	chr17	7578502	7578502	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tggaatcaacccacagctgcAcagggcaggtcttggccagt	12	12	2	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:7578502A>C	ENST00000420246.2	-	5	560	c.428T>G	c.(427-429)gTg>gGg	p.V143G	TP53_ENST00000445888.2_Missense_Mutation_p.V143G|TP53_ENST00000359597.4_Missense_Mutation_p.V143G|TP53_ENST00000413465.2_Missense_Mutation_p.V143G|TP53_ENST00000269305.4_Missense_Mutation_p.V143G|TP53_ENST00000455263.2_Missense_Mutation_p.V143G	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	143	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143A(18)|p.0?(8)|p.V143E(5)|p.V11A(2)|p.V50A(2)|p.L137_W146del10(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACAGCTGCACAGGGCAGGT	0.587		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	1					0	0	1	0	0	C	7578502	A	C	7578502	3	2	12	1	0	0	0	0	1	0	0	0	16441	159	6	4	870	4	TP53	17	7578502	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08		7578502	73616708	54	854										
SARM1	23098	broad.mit.edu	37	chr17	26715423	26715423	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	agtgtcttcattgatgtggaGaagctggaagcaggcaagtt	14	5	2	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:26715423G>C	ENST00000457710.3	+	7	2157	c.1686G>C	c.(1684-1686)gaG>gaC	p.E562D	SARM1_ENST00000379061.4_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	596	TIR.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TTGATGTGGAGAAGCTGGAAG	0.547													30	43					0	0	1	0	0	C	26715423	G	C	26715423	3	2	12	1	0	0	0	0	1	0	0	0	13894	933	33	2	1812	2	SARM1	17	26715423	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	19136921	26715423	54479787	55	855										
SLC25A39	51629	broad.mit.edu	37	chr17	42398463	42398463	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cgaagggcagtggggccccaGcccagccacagtgagcgcca	15	15	0	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:42398463G>A	ENST00000225308.8	-	8	804	c.630C>T	c.(628-630)ggC>ggT	p.G210G	SLC25A39_ENST00000590194.1_Silent_p.G210G|SLC25A39_ENST00000537904.2_Silent_p.G195G|SLC25A39_ENST00000586016.1_Silent_p.G86G|SLC25A39_ENST00000377095.5_Silent_p.G218G	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	218					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGGGGCCCCAGCCCAGCCACA	0.637													10	36					0	0	1	0	0	A	42398463	G	A	42398463	2	1	12	1	0	0	0	0	0	0	0	1	14557	958	34	3		3	SLC25A39	17	42398463	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	15683040	42398463	38796747	56	856										
FZD2	2535	broad.mit.edu	37	chr17	42636744	42636744	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	caacagccgacacggtgagaCcaccgtgtgagggacgcccc	13	15	0	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:42636744C>T	ENST00000315323.3	+	1	1820	c.1688C>T	c.(1687-1689)aCc>aTc	p.T563I		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	563					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CACGGTGAGACCACCGTGTGA	0.597													19	12					0	0	1	0	0	T	42636744	C	T	42636744	3	4	12	1	0	0	0	0	1	0	0	0	6164	507	18	3	1690	3	FZD2	17	42636744	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	238281	42636744	38558466	57	857										
BZRAP1	9256	broad.mit.edu	37	chr17	56386693	56386693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gggcagctccaggatctgctCcaagatctcctcatcgctgt	10	14	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:56386693C>T	ENST00000355701.3	-	22	4810	c.3940G>A	c.(3940-3942)Gag>Aag	p.E1314K	BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1254K|BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1314K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1314						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGATCTGCTCCAAGATCTCC	0.577													42	47					0	0	1	0	0	T	56386693	C	T	56386693	3	4	12	1	0	0	0	0	1	0	0	0	1580	864	30	3	1673	3	BZRAP1	17	56386693	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	13749949	56386693	24808517	58	858										
DNAH17	8632	broad.mit.edu	37	chr17	76490708	76490708	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	aggtcccgtttccgaggcacGtccagagccgggaagaggtc	15	12	0	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:76490708G>A	ENST00000389840.5	-	40	6319	c.6195C>T	c.(6193-6195)gaC>gaT	p.D2065D	DNAH17_ENST00000585328.1_Silent_p.D2074D|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCGAGGCACGTCCAGAGCCG	0.587													30	130					0	0	1	0	0	A	76490708	G	A	76490708	2	1	12	1	0	0	0	0	0	0	0	1	4629	1136	40	1		1	DNAH17	17	76490708	Silent	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08	20104015	76490708	4704502	59	859										
ZNF676	163223	broad.mit.edu	37	chr19	22363519	22363519	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ttcacatttgtagggtttctCtccagcatgaattctcttgt	7	9	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr19:22363519C>G	ENST00000397121.2	-	3	1317	c.1000G>C	c.(1000-1002)Gag>Cag	p.E334Q		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TAGGGTTTCTCTCCAGCATGA	0.408													32	34					0	0	1	0	0	G	22363519	C	G	22363519	3	3	12	1	0	0	0	0	1	0	0	0	18139	922	32	2	770	2	ZNF676	19	22363519	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		22363519	36765464	60	860										
FFAR2	2867	broad.mit.edu	37	chr19	35941555	35941555	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gcagaggggacaaatgaggaCaggggtgtgggtcaaggaga	20	4	1	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr19:35941555C>T	ENST00000599180.1	+	2	1019	c.939C>T	c.(937-939)gaC>gaT	p.D313D	FFAR2_ENST00000246549.2_Silent_p.D313D|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	313						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAAATGAGGACAGGGGTGTGG	0.587													16	59					0	0	1	0	0	T	35941555	C	T	35941555	2	4	12	1	0	0	0	0	0	0	0	1	5860	477	17	3		3	FFAR2	19	35941555	Silent	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	13578036	35941555	23187428	61	861										
CHD6	0	broad.mit.edu	37	chr20	40113160	40113161	+	Frame_Shift_Del	DEL	TC	TC	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cagttccacctcaatgatcgTctcttgtttgggagcaaggt					rs146144596		TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr20:40113160_40113161delTC	ENST00000373233.3	-	15	2265_2266	c.2088_2089delGA	c.(2086-2091)gacgfs	p.ET696fs	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	696					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TCAATGATCGTCTCTTGTTTGG	0.455													64	71	---	---	---	---						-	40113161	TC	-	40113160	7	5	12	1	0	1	0	1	0	0	0	0	3351	1667	58	0	6150	0	CHD6	20	40113160	Frame_Shift_Del	DEL	TC	TCGA-N5-A4RV-01A-21D-A28R-08		40113160	22912360	62	862										
COL20A1	57642	broad.mit.edu	37	chr20	61951483	61951483	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ggggagatgggcagcccaccCgctgcgggcttcgtcacgct	16	14	1	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr20:61951483C>T	ENST00000422202.1	+	23	3098	c.3030C>T	c.(3028-3030)ccC>ccT	p.P1010P	COL20A1_ENST00000435874.1_Silent_p.P1010P|COL20A1_ENST00000358894.6_Silent_p.P1003P|COL20A1_ENST00000326996.6_Silent_p.P1003P			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1003	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GCAGCCCACCCGCTGCGGGCT	0.716													10	4					0	0	1	0	0	T	61951483	C	T	61951483	2	4	12	1	0	0	0	0	0	0	0	1	3702	639	23	1		1	COL20A1	20	61951483	Silent	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	21838323	61951483	1074037	63	863										
BAGE2	85319	broad.mit.edu	37	chr21	11058882	11058882	+	RNA	DEL	A	A	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	aaaagatggaaatgtgggggAaaaaaattagtcatctggta					rs145149071		TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr21:11058882delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATGTGGGGGAAAAAAATTAG	0.358													4	3	---	---	---	---						-	11058882	A	-	11058882	6	5	12	0	1	1	0	1	0	0	0	0	1290	261	9	0		0	BAGE2	21	11058882	RNA	DEL	A	TCGA-N5-A4RV-01A-21D-A28R-08		11058882	37071013	64	864										
BAGE2	85319	broad.mit.edu	37	chr21	11096512	11096516	+	RNA	DEL	GTTTT	GTTTT	-													0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cagtgcctaaccatttttaaGttttgttttgttttgttttg							TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr21:11096512_11096516delGTTTT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccATTTTTAAgttttgttttgtttt	0.493													4	8	---	---	---	---						-	11096516	GTTTT	-	11096512	6	5	12	0	1	1	0	1	0	0	0	0	1290	1044	36	0		0	BAGE2	21	11096512	RNA	DEL	GTTTT	TCGA-N5-A4RV-01A-21D-A28R-08	37630	11096512	37033383	65	865										
MX2	4600	broad.mit.edu	37	chr21	42775253	42775253	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	attttggcgaatttttcaacCttaaccaaactgttcaggta	6	8	2	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr21:42775253C>G	ENST00000330714.3	+	12	1817	c.1633C>G	c.(1633-1635)Ctt>Gtt	p.L545V		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	545					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				ATTTTTCAACCTTAACCAAAC	0.393													33	28					0	0	1	0	0	G	42775253	C	G	42775253	3	3	12	1	0	0	0	0	1	0	0	0	10045	681	24	5	1675	5	MX2	21	42775253	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	31678741	42775253	5354642	66	866										
BCL2L13	23786	broad.mit.edu	37	chr22	18185097	18185097	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	gagcgcactgctgcagtttgGcgtgacatacctggaggact	14	10	0	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr22:18185097G>C	ENST00000317582.5	+	6	892	c.545G>C	c.(544-546)gGc>gCc	p.G182A	BCL2L13_ENST00000418951.2_Intron|BCL2L13_ENST00000543133.1_Missense_Mutation_p.G20A|BCL2L13_ENST00000493680.1_Missense_Mutation_p.G182A|BCL2L13_ENST00000355028.3_Intron|BCL2L13_ENST00000538149.1_Missense_Mutation_p.G58A|BCL2L13_ENST00000399782.1_Missense_Mutation_p.G182A|BCL2L13_ENST00000337612.5_Missense_Mutation_p.G20A	NM_015367.2	NP_056182.2	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	182					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		CTGCAGTTTGGCGTGACATAC	0.403													37	47					0	0	1	0	0	C	18185097	G	C	18185097	3	2	12	1	0	0	0	0	1	0	0	0	1369	1203	42	5	563	5	BCL2L13	22	18185097	Missense_Mutation	SNP	G	TCGA-N5-A4RV-01A-21D-A28R-08		18185097	33119469	67	867										
ALG12	79087	broad.mit.edu	37	chr22	50297568	50297568	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	ggggcagttgggtcaggttcAgactcacacctgtggtcccc	14	12	3	1			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr22:50297568A>C	ENST00000330817.5	-	10	1658	c.1385T>G	c.(1384-1386)cTg>cGg	p.L462R		NM_024105.3	NP_077010.1	Q9BV10	ALG12_HUMAN	ALG12, alpha-1,6-mannosyltransferase	462					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(3)	12		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCAGGTTCAGACTCACACC	0.657													11	48					0	0	1	0	0	C	50297568	A	C	50297568	3	2	12	1	0	0	0	0	1	0	0	0	511	188	7	4	85	4	ALG12	22	50297568	Missense_Mutation	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	32112471	50297568	1006998	68	868										
USP51	158880	broad.mit.edu	37	chrX	55515333	55515333	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	tccggagatccagcggacccCagagccggagggcaaagaag	15	12	0	3			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:55515333C>T	ENST00000500968.3	-	2	122	c.40G>A	c.(40-42)Ggg>Agg	p.G14R		NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	14					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						CAGCGGACCCCAGAGCCGGAG	0.627													8	16					0	0	1	0	0	T	55515333	C	T	55515333	3	4	12	1	0	0	0	0	1	0	0	0	17142	594	21	3	2099	3	USP51	23	55515333	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08		55515333	99755227	69	869										
GRIA3	2892	broad.mit.edu	37	chrX	122387246	122387246	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cctccttctgtggggccctgCacacatcctttgttacgcct	8	16	1	0			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:122387246C>A	ENST00000264357.5	+	3	653	c.361C>A	c.(361-363)Cac>Aac	p.H121N	GRIA3_ENST00000371256.5_Missense_Mutation_p.H121N|GRIA3_ENST00000542149.1_Missense_Mutation_p.H121N|GRIA3_ENST00000479118.1_3'UTR|GRIA3_ENST00000541091.1_Missense_Mutation_p.H105N|GRIA3_ENST00000371251.1_Missense_Mutation_p.H121N	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	121					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.H121N(2)		breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TGGGGCCCTGCACACATCCTT	0.537													27	89					8.58068e-18	9.74596e-18	1	1	0	A	122387246	C	A	122387246	3	1	12	1	0	0	0	0	1	0	0	0	6809	710	25	5	371	5	GRIA3	23	122387246	Missense_Mutation	SNP	C	TCGA-N5-A4RV-01A-21D-A28R-08	66871913	122387246	32883314	70	870										
USP26	83844	broad.mit.edu	37	chrX	132161820	132161820	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0422535211267606	3	1	0.764150943396226	2.36192109777015	0	0.166666666666667	0.67857142857143	0	cttccttttgctatctcaaaAgatttgctacttgatttctc	4	10	2	2			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:132161820A>T	ENST00000511190.1	-	6	898	c.429T>A	c.(427-429)tcT>tcA	p.S143S	USP26_ENST00000406273.1_Silent_p.S143S|USP26_ENST00000370832.1_Silent_p.S143S	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	143					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					CTATCTCAAAAGATTTGCTAC	0.408													12	28					0	0	1	0	0	T	132161820	A	T	132161820	2	4	12	1	0	0	0	0	0	0	0	1	17116	59	3	4		4	USP26	23	132161820	Silent	SNP	A	TCGA-N5-A4RV-01A-21D-A28R-08	9774574	132161820	23108740	71	871										
TNFRSF14	8764	broad.mit.edu	37	chr1	2492102	2492102	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctgtgtcagaactgcccccCggggaccttctctcccaatg	9	17	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:2492102C>T	ENST00000355716.4	+	5	799	c.500C>T	c.(499-501)cCg>cTg	p.P167L	TNFRSF14_ENST00000409119.1_Missense_Mutation_p.P167L	NM_003820.2	NP_003811.2	Q92956	TNR14_HUMAN	tumor necrosis factor receptor superfamily, member 14	167					immune response|interspecies interaction between organisms|T cell costimulation		tumor necrosis factor receptor activity			kidney(1)	1	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;1.11e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000326)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		AACTGCCCCCCGGGGACCTTC	0.672			"Mis, N, F"		follicular lymphoma								20	14					0	0	1	0	0	T	2492102	C	T	2492102	3	4	13	1	0	0	0	0	1	0	0	0	16348	652	23	1	518	1	TNFRSF14	1	2492102	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		2492102	246758519	1	872										
MMEL1	79258	broad.mit.edu	37	chr1	2537800	2537800	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctgccgctccagctcccactCgagtcctggggagacagtgc	12	16	0	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:2537800C>G	ENST00000288709.6	-	8	850	c.610G>C	c.(610-612)Gag>Cag	p.E204Q	MMEL1_ENST00000378412.3_Missense_Mutation_p.E213Q|MMEL1_ENST00000502556.1_Intron	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	213					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		AGCTCCCACTCGAGTCCTGGG	0.657													10	22					0	0	1	0	0	G	2537800	C	G	2537800	3	3	13	1	0	0	0	0	1	0	0	0	9693	893	31	2	1770	2	MMEL1	1	2537800	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	45698	2537800	246712821	2	873										
CAPZB	832	broad.mit.edu	37	chr1	19712043	19712043	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tagtcacacaaaaggtaatcCtttcccaccaccttgtctct	4	14	2	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:19712043C>T	ENST00000264203.3	-	4	742	c.249G>A	c.(247-249)aaG>aaA	p.K83K	CAPZB_ENST00000375144.1_Silent_p.K45K|CAPZB_ENST00000375142.1_Silent_p.K57K|CAPZB_ENST00000401084.2_Silent_p.K57K|CAPZB_ENST00000482808.1_5'UTR|CAPZB_ENST00000264202.6_Silent_p.K57K|CAPZB_ENST00000433834.1_Silent_p.K86K			P47756	CAPZB_HUMAN	capping protein (actin filament) muscle Z-line, beta	57					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		AAAGGTAATCCTTTCCCACCA	0.547													20	27					0	0	1	0	0	T	19712043	C	T	19712043	2	4	13	1	0	0	0	0	0	0	0	1	2661	680	24	3		3	CAPZB	1	19712043	Silent	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	17174243	19712043	229538578	3	874										
CSMD2	114784	broad.mit.edu	37	chr1	33999485	33999485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gcaggtagcctttttgacaaCggaagaggactgtgcttcca	12	9	0	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:33999485C>T	ENST00000373381.4	-	63	10078	c.9902G>A	c.(9901-9903)cGt>cAt	p.R3301H		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3157						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTTTTGACAACGGAAGAGGAC	0.562													17	11					0	0	1	0	0	T	33999485	C	T	33999485	3	4	13	1	0	0	0	0	1	0	0	0	3970	536	19	1	1025	1	CSMD2	1	33999485	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	14287442	33999485	215251136	4	875										
PTPRF	5792	broad.mit.edu	37	chr1	44075093	44075093	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tcctctaaggatgagcagtcGatcggactgaaggactcctt	11	10	1	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:44075093G>C	ENST00000359947.4	+	22	4237	c.3897G>C	c.(3895-3897)tcG>tcC	p.S1299S	PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.S1290S|PTPRF_ENST00000422171.2_Silent_p.S647S|PTPRF_ENST00000372414.3_Silent_p.S1299S|PTPRF_ENST00000438120.1_Silent_p.S1290S	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1299					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGAGCAGTCGATCGGACTGA	0.577													5	32					0	0	1	0	0	C	44075093	G	C	44075093	2	2	13	1	0	0	0	0	0	0	0	1	12852	1045	37	2		2	PTPRF	1	44075093	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	10075608	44075093	205175528	5	876										
TRIM33	51592	broad.mit.edu	37	chr1	115006917	115006917	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctgatttttcatcagaactgCtaggagcttcagatgtgtct	9	8	4	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:115006917C>G	ENST00000358465.2	-	2	703	c.620G>C	c.(619-621)aGc>aCc	p.S207T	TRIM33_ENST00000369543.2_Missense_Mutation_p.S207T	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	207					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCAGAACTGCTAGGAGCTTC	0.358			T	RET	papillary thyroid								6	11					0	0	1	0	0	G	115006917	C	G	115006917	3	3	13	1	0	0	0	0	1	0	0	0	16567	797	28	5	2839	5	TRIM33	1	115006917	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	70931824	115006917	134243704	6	877										
FLG	2312	broad.mit.edu	37	chr1	152278956	152278956	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gagctatctaccgaatgctcGtggtggtacccctgccttcc	10	14	1	0	rs137870179	byFrequency	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:152278956G>A	ENST00000368799.1	-	3	8441	c.8406C>T	c.(8404-8406)caC>caT	p.H2802H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2802	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.H2802Q(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGAATGCTCGTGGTGGTACC	0.597									Ichthyosis				17	763					0	0	1	0	0	A	152278956	G	A	152278956	2	1	13	1	0	0	0	0	0	0	0	1	5954	1136	40	1		1	FLG	1	152278956	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	37272039	152278956	96971665	7	878										
CRTC2	200186	broad.mit.edu	37	chr1	153925843	153925843	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gaagggcagagtcagagcttGtcctatggggggagcaggaa	18	6	1	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:153925843G>A	ENST00000368633.1	-	6	633	c.506C>T	c.(505-507)aCa>aTa	p.T169I	CRTC2_ENST00000476883.1_5'UTR|CRTC2_ENST00000368630.3_Intron	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	169					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTCAGAGCTTGTCCTATGGGG	0.592													5	57					0	0	1	0	0	A	153925843	G	A	153925843	3	1	13	1	0	0	0	0	1	0	0	0	3923	1377	48	3	1611	3	CRTC2	1	153925843	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	1646887	153925843	95324778	8	879										
SLAMF6	114836	broad.mit.edu	37	chr1	160466086	160466088	+	In_Frame_Del	DEL	CTT	CTT	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	agccaagtgatgaagttgacCttctctcctgcaggaaactc							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:160466086_160466088delCTT	ENST00000368059.3	-	2	214_216	c.145_147delAAG	c.(145-147)del	p.K49del	SLAMF6_ENST00000368057.3_In_Frame_Del_p.K49del|SLAMF6_ENST00000368055.1_Intron	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	49						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TGAAGTTGACCTTCTCTCCTGCA	0.458													96	194	---	---	---	---						-	160466088	CTT	-	160466086	7	5	13	1	0	1	0	1	0	0	0	0	14422	680	24	0	879	0	SLAMF6	1	160466086	In_Frame_Del	DEL	CTT	TCGA-N5-A59E-01A-11D-A28R-08	6540243	160466086	88784535	9	880										
KCNT2	343450	broad.mit.edu	37	chr1	196397292	196397292	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tccataagtaaatcaatcttCagtgagctgacacacaggac	7	10	3	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:196397292C>T	ENST00000367433.5	-	10	1028	c.927G>A	c.(925-927)ctG>ctA	p.L309L	KCNT2_ENST00000294725.8_Silent_p.L309L|KCNT2_ENST00000367431.4_Silent_p.L309L|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Intron			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	309						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AATCAATCTTCAGTGAGCTGA	0.393													4	35					0	0	1	0	0	T	196397292	C	T	196397292	2	4	13	1	0	0	0	0	0	0	0	1	8135	813	29	3		3	KCNT2	1	196397292	Silent	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	35931206	196397292	52853329	10	881										
CTSE	1510	broad.mit.edu	37	chr1	206318413	206318414	+	Frame_Shift_Ins	INS	-	-	GA													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tggacatgatccagttcaccINSgagtcctgctcaatggacca							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:206318413_206318414insGA	ENST00000361052.3	+	2	289_290	c.171_172insGA	c.(169-174)acagtcfs	p.V58fs	CTSE_ENST00000360218.2_Frame_Shift_Ins_p.V58fs|CTSE_ENST00000432969.2_Intron|CTSE_ENST00000358184.2_Frame_Shift_Ins_p.V58fs			P14091	CATE_HUMAN	cathepsin E	58					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			TCCAGTTCACCGAGTCCTGCTC	0.584													39	75	---	---	---	---						GA	206318414	-	GA	206318413	7	5	13	1	0	1	1	0	0	0	0	0	4057	639	23	0	177	0	CTSE	1	206318413	Frame_Shift_Ins	INS	-	TCGA-N5-A59E-01A-11D-A28R-08	9921121	206318413	42932208	11	882										
SUSD4	55061	broad.mit.edu	37	chr1	223396671	223396671	+	Frame_Shift_Del	DEL	G	G	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tgtcagggttgtccgaagcaGggtgggtgctctcttggcac							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:223396671delG	ENST00000343846.3	-	7	1997	c.1364delC	c.(1363-1365)ctfs	p.P455fs	SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000454695.2_Frame_Shift_Del_p.P295fs|SUSD4_ENST00000366878.4_Frame_Shift_Del_p.P455fs			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	455						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GTCCGAAGCAGGGTGGGTGCT	0.587													13	120	---	---	---	---						-	223396671	G	-	223396671	7	5	13	1	0	1	0	1	0	0	0	0	15465	1000	35	0	116	0	SUSD4	1	223396671	Frame_Shift_Del	DEL	G	TCGA-N5-A59E-01A-11D-A28R-08	17078258	223396671	25853950	12	883										
SLC8A1	6546	broad.mit.edu	37	chr2	40656143	40656143	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctctgcggataatggtaagGgccacagtaccacagttctc	10	12	2	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:40656143G>A	ENST00000406785.1	-	2	1467	c.1278C>T	c.(1276-1278)gcC>gcT	p.A426A	SLC8A1_ENST00000542756.1_Silent_p.A426A|SLC8A1_ENST00000332839.4_Silent_p.A426A|SLC8A1_ENST00000542024.1_Silent_p.A426A|SLC8A1_ENST00000408028.2_Silent_p.A426A|SLC8A1_ENST00000406391.2_Silent_p.A426A|SLC8A1_ENST00000405269.1_Silent_p.A426A|SLC8A1_ENST00000403092.1_Silent_p.A426A|SLC8A1_ENST00000405901.3_Silent_p.A426A|SLC8A1_ENST00000402441.1_Silent_p.A426A			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	426	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.A426A(1)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TAATGGTAAGGGCCACAGTAC	0.438													11	111					0	0	1	0	0	A	40656143	G	A	40656143	2	1	13	1	0	0	0	0	0	0	0	1	14760	1219	43	3		3	SLC8A1	2	40656143	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		40656143	202543230	13	884										
RANBP2	5903	broad.mit.edu	37	chr2	109398713	109398713	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	atataaagattctttggcatAcaatgaagaattattaccgg	7	5	1	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:109398713A>G	ENST00000283195.6	+	27	9016	c.8890A>G	c.(8890-8892)Aca>Gca	p.T2964A		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2964	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TCTTTGGCATACAATGAAGAA	0.373													20	26					0	0	1	0	0	G	109398713	A	G	109398713	3	3	13	1	0	0	0	0	1	0	0	0	13079	391	14	4	8996	4	RANBP2	2	109398713	Missense_Mutation	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	68742570	109398713	133800660	14	885										
CCDC115	84317	broad.mit.edu	37	chr2	131099731	131099731	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	agatctggagccaccttcttCcttgtcaccctccgcagttt	7	15	3	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:131099731C>T	ENST00000437688.2	-	1	180	c.72G>A	c.(70-72)agG>agA	p.R24R	CCDC115_ENST00000259229.2_5'UTR|CCDC115_ENST00000409127.1_Silent_p.R24R			Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	0						endosome|lysosome				central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	7	Colorectal(110;0.1)					CCACCTTCTTCCTTGTCACCC	0.627													5	8					0	0	1	0	0	T	131099731	C	T	131099731	2	4	13	1	0	0	0	0	0	0	0	1	2770	870	30	3		3	CCDC115	2	131099731	Silent	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	21701018	131099731	112099642	15	886										
TANC1	85461	broad.mit.edu	37	chr2	160031574	160031598	+	Frame_Shift_Del	DEL	CAGAGACCTTCTGATAAAGGAGCCC	CAGAGACCTTCTGATAAAGGAGCCC	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tcccatcagctggccgcctaCagagaccttctgataaagga							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:160031574_160031598delCAGAGACCTTCTGATAAAGGAGCCC	ENST00000263635.6	+	12	1851_1875	c.1614_1638delCAGAGACCTTCTGATAAAGGAGCCC	c.(1612-1638)tafs	p.YRDLLIKEP538fs	TANC1_ENST00000454300.1_Frame_Shift_Del_p.YRDLLIKEP432fs	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	538						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TGGCCGCCTACAGAGACCTTCTGATAAAGGAGCCCCAACTACAGA	0.573													20	133	---	---	---	---						-	160031598	CAGAGACCTTCTGATAAAGGAGCCC	-	160031574	7	5	13	1	0	1	0	1	0	0	0	0	15600	489	17	0	1652	0	TANC1	2	160031574	Frame_Shift_Del	DEL	CAGAGACCTTCTGATAAAGGAGCCC	TCGA-N5-A59E-01A-11D-A28R-08	28931843	160031574	83167799	16	887										
TRPM8	79054	broad.mit.edu	37	chr2	234847659	234847659	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tagtatatacgtctgtcctgCgacacggacgcggaaatcct	10	11	1	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:234847659C>A	ENST00000324695.4	+	5	406	c.366C>A	c.(364-366)tgC>tgA	p.C122*	TRPM8_ENST00000409625.1_Nonsense_Mutation_p.C45*|TRPM8_ENST00000355722.4_Nonsense_Mutation_p.C72*|TRPM8_ENST00000433712.2_5'UTR	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	122						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTCTGTCCTGCGACACGGACG	0.547													54	27					3.16986e-14	3.53917e-14	1	1	0	A	234847659	C	A	234847659	4	1	13	1	0	0	0	0	0	1	0	0	16652	776	27	5	380	5	TRPM8	2	234847659	Nonsense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	74816085	234847659	8351714	17	888										
GRM7	2917	broad.mit.edu	37	chr3	7456839	7456839	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	aaaaaaagaagacacagatcGcaaatgcacaggtaatttaa	7	6	0	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:7456839G>A	ENST00000486284.1	+	5	1437	c.1163G>A	c.(1162-1164)cGc>cAc	p.R388H	GRM7_ENST00000402647.2_Missense_Mutation_p.R388H|GRM7_ENST00000403881.1_Missense_Mutation_p.R388H|GRM7_ENST00000357716.4_Missense_Mutation_p.R388H|GRM7_ENST00000389336.4_Missense_Mutation_p.R388H	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	388					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.R388P(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GACACAGATCGCAAATGCACA	0.423													19	21					0	0	1	0	0	A	7456839	G	A	7456839	3	1	13	1	0	0	0	0	1	0	0	0	6842	1087	38	1	1181	1	GRM7	3	7456839	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		7456839	190565591	18	889										
ATP2B2	491	broad.mit.edu	37	chr3	10452444	10452444	+	Frame_Shift_Del	DEL	G	G	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ggcttctttggaggtataaaGttttgcccaaaaatttgctt							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:10452444delG	ENST00000397077.1	-	5	830	c.255delC	c.(253-255)aafs	p.N85fs	ATP2B2_ENST00000383800.4_Frame_Shift_Del_p.N85fs|ATP2B2_ENST00000360273.2_Frame_Shift_Del_p.N85fs|ATP2B2_ENST00000352432.4_Frame_Shift_Del_p.N85fs|ATP2B2_ENST00000343816.4_Frame_Shift_Del_p.N85fs			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	85					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GAGGTATAAAGTTTTGCCCAA	0.547													8	385	---	---	---	---						-	10452444	G	-	10452444	7	5	13	1	0	1	0	1	0	0	0	0	1139	1020	36	0	3560	0	ATP2B2	3	10452444	Frame_Shift_Del	DEL	G	TCGA-N5-A59E-01A-11D-A28R-08	2995605	10452444	187569986	19	890										
DCP1A	55802	broad.mit.edu	37	chr3	53321609	53321609	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctgctccagtcataggttgtGgttgtctttgttcttggtca	11	8	4	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:53321609G>T	ENST00000607628.1	-	10	1853	c.1744C>A	c.(1744-1746)Cac>Aac	p.H582N	DCP1A_ENST00000606822.1_Missense_Mutation_p.H544N|DCP1A_ENST00000480258.1_5'UTR|DCP1A_ENST00000294241.6_Missense_Mutation_p.H580N	NM_018403.5	NP_060873.4	Q9NPI6	DCP1A_HUMAN	decapping mRNA 1A	580					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		CATAGGTTGTGGTTGTCTTTG	0.433													17	32					3.32936e-07	3.61204e-07	1	1	0	T	53321609	G	T	53321609	3	4	13	1	0	0	0	0	1	0	0	0	4321	1348	47	5	14	5	DCP1A	3	53321609	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	42869165	53321609	144700821	20	891										
CCDC66	285331	broad.mit.edu	37	chr3	56647723	56647723	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gcttcgcttagcacaggaacGtgaagagatgcagaaacagt	12	8	0	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:56647723G>T	ENST00000394672.3	+	11	1581	c.1511G>T	c.(1510-1512)cGt>cTt	p.R504L	CCDC66_ENST00000436465.2_Missense_Mutation_p.R504L|CCDC66_ENST00000326595.7_Missense_Mutation_p.R470L	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	504										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		GCACAGGAACGTGAAGAGATG	0.398													39	41					9.8876e-21	1.11478e-20	1	1	0	T	56647723	G	T	56647723	3	4	13	1	0	0	0	0	1	0	0	0	2858	1145	40	5	1553	5	CCDC66	3	56647723	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	3326114	56647723	141374707	21	892										
GPR15	2838	broad.mit.edu	37	chr3	98251260	98251260	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctcctgctcacttgcatgaGtgttgaccgctacctggcca	9	15	1	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:98251260G>A	ENST00000284311.3	+	1	518	c.383G>A	c.(382-384)aGt>aAt	p.S128N		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	128						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		ACTTGCATGAGTGTTGACCGC	0.522													19	37					0	0	1	0	0	A	98251260	G	A	98251260	3	1	13	1	0	0	0	0	1	0	0	0	6694	1029	36	3	385	3	GPR15	3	98251260	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	41603537	98251260	99771170	22	893										
ATP13A3	79572	broad.mit.edu	37	chr3	194181555	194181555	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cgactcaaattgtaaccataAatctcctgcatggacacagc	6	12	2	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:194181555A>G	ENST00000439040.1	-	4	848	c.57T>C	c.(55-57)atT>atC	p.I19I	ATP13A3_ENST00000256031.4_Silent_p.I19I			Q9H7F0	AT133_HUMAN	ATPase type 13A3	19					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TGTAACCATAAATCTCCTGCA	0.403													14	104					0	0	1	0	0	G	194181555	A	G	194181555	2	3	13	1	0	0	0	0	0	0	0	1	1124	10	1	4		4	ATP13A3	3	194181555	Silent	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	95930295	194181555	3840875	23	894										
MUC4	4585	broad.mit.edu	37	chr3	195511283	195511283	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	acctgtggatgctgaggaagCgtcggtgacaggaagagggg	19	6	0	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:195511283C>T	ENST00000463781.3	-	2	7627	c.7168G>A	c.(7168-7170)Gct>Act	p.A2390T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.A2390T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	148					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.A2390T(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCTGAGGAAGCGTCGGTGACA	0.592													4	31					0	0	1	0	0	T	195511283	C	T	195511283	3	4	13	1	0	0	0	0	1	0	0	0	10025	768	27	1		1	MUC4	3	195511283	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	1329728	195511283	2511147	24	895										
MUC4	4585	broad.mit.edu	37	chr3	195511815	195511815	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gtggatgctgaggaagggctGgtgacaggaagaggggtggc	22	4	0	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:195511815G>A	ENST00000463781.3	-	2	7095	c.6636C>T	c.(6634-6636)acC>acT	p.T2212T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.T2212T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1001					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T2212T(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGGGCTGGTGACAGGAA	0.602													4	32					0	0	1	0	0	A	195511815	G	A	195511815	2	1	13	1	0	0	0	0	0	0	0	1	10025	1335	47	3		3	MUC4	3	195511815	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	532	195511815	2510615	25	896										
MTHFD2L	441024	broad.mit.edu	37	chr4	75065519	75065519	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tttatttttcagaccacgttGatgagcgaacaatatgcaat	7	7	1	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr4:75065519G>C	ENST00000395759.2	+	4	487	c.460G>C	c.(460-462)Gat>Cat	p.D154H	MTHFD2L_ENST00000331145.6_Missense_Mutation_p.D96H|MTHFD2L_ENST00000433372.1_Missense_Mutation_p.D19H|MTHFD2L_ENST00000325278.6_Missense_Mutation_p.D96H	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	96					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			AGACCACGTTGATGAGCGAAC	0.313													17	39					0	0	1	0	0	C	75065519	G	C	75065519	3	2	13	1	0	0	0	0	1	0	0	0	9977	1290	45	2	474	2	MTHFD2L	4	75065519	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		75065519	116088757	26	897										
ARSJ	79642	broad.mit.edu	37	chr4	114899926	114899926	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cccccattgctagcatctttCcaggacagacacaggcctgt	8	15	1	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr4:114899926C>A	ENST00000315366.7	-	1	931	c.65G>T	c.(64-66)gGa>gTa	p.G22V	ARSJ_ENST00000541197.1_Missense_Mutation_p.G22V|ARSJ_ENST00000503013.2_5'UTR	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	22						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TAGCATCTTTCCAGGACAGAC	0.607													138	15					7.39696e-70	8.68011e-70	1	1	0	A	114899926	C	A	114899926	3	1	13	1	0	0	0	0	1	0	0	0	994	855	30	2	1742	2	ARSJ	4	114899926	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	39834407	114899926	76254350	27	898										
SDHA	6389	broad.mit.edu	37	chr5	240531	240531	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gaatctgtcatgaatcttgaCaaattgagatttgctgatgg	10	5	3	4			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr5:240531C>G	ENST00000264932.6	+	11	1606	c.1491C>G	c.(1489-1491)gaC>gaG	p.D497E	SDHA_ENST00000510361.1_Missense_Mutation_p.D449E|SDHA_ENST00000504309.1_Missense_Mutation_p.D497E	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	497					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TGAATCTTGACAAATTGAGAT	0.428									Familial Paragangliomas				4	73					0	0	1	0	0	G	240531	C	G	240531	3	3	13	1	0	0	0	0	1	0	0	0	14016	477	17	5	1533	5	SDHA	5	240531	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		240531	180674729	28	899										
HIST1H2AB	8335	broad.mit.edu	37	chr6	26033563	26033563	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tgcaggtggcgcgggatgatGcgggtcttcttgttgtcgcg	18	8	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:26033563G>A	ENST00000259791.2	-	1	233	c.234C>T	c.(232-234)cgC>cgT	p.R78R		NM_003513.2	NP_003504.2	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	78					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						GCGGGATGATGCGGGTCTTCT	0.622													34	106					0	0	1	0	0	A	26033563	G	A	26033563	2	1	13	1	0	0	0	0	0	0	0	1	7169	1306	46	3		3	HIST1H2AB	6	26033563	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		26033563	145081504	29	900										
TNXB	7148	broad.mit.edu	37	chr6	32029445	32029445	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	aggagcggctcctcagggggCtccggggcctccatgctggg	18	13	1	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:32029445C>A	ENST00000375244.3	-	21	7422	c.7221G>T	c.(7219-7221)gaG>gaT	p.E2407D	TNXB_ENST00000375247.2_Missense_Mutation_p.E2407D			P22105	TENX_HUMAN	tenascin XB	2467	Fibronectin type-III 16.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCTCAGGGGGCTCCGGGGCCT	0.657													5	102					0.00116845	0.00121055	1	1	0	A	32029445	C	A	32029445	3	1	13	1	0	0	0	0	1	0	0	0	16405	796	28	5	7588	5	TNXB	6	32029445	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	5995882	32029445	139085622	30	901										
PKHD1	5314	broad.mit.edu	37	chr6	51889956	51889956	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	catttcttgtataaaaaactGacaggtagtggggtcctggg	12	6	1	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:51889956G>T	ENST00000371117.3	-	32	4927	c.4652C>A	c.(4651-4653)tCa>tAa	p.S1551*	PKHD1_ENST00000340994.4_Nonsense_Mutation_p.S1551*	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1551	IPT/TIG 10.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ATAAAAAACTGACAGGTAGTG	0.403													10	51					0.0581538	0.0586639	1	1	0	T	51889956	G	T	51889956	4	4	13	1	0	0	0	0	0	1	0	0	12018	1294	45	2	7755	2	PKHD1	6	51889956	Nonsense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	19860511	51889956	119225111	31	902										
SLC35D3	340146	broad.mit.edu	37	chr6	137243603	137243603	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ggggccgcgtgctgggcatcTcggtggccatcgcgcacggg	19	13	1	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:137243603T>G	ENST00000331858.4	+	1	202	c.37T>G	c.(37-39)Tcg>Gcg	p.S13A		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	13					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GCTGGGCATCTCGGTGGCCAT	0.701													4	14					0	0	1	0	0	G	137243603	T	G	137243603	3	3	13	1	0	0	0	0	1	0	0	0	14637	1551	54	4	39	4	SLC35D3	6	137243603	Missense_Mutation	SNP	T	TCGA-N5-A59E-01A-11D-A28R-08	85353647	137243603	33871464	32	903										
ZNF425	155054	broad.mit.edu	37	chr7	148809307	148809307	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	agttgtccttcttgttttatCtaagcatccctgttcgctga	7	10	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr7:148809307C>G	ENST00000378061.2	-	3	358	c.226G>C	c.(226-228)Gat>Cat	p.D76H	ZNF425_ENST00000484196.1_5'UTR	NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	76	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTTGTTTTATCTAAGCATCCC	0.398													4	73					0	0	1	0	0	G	148809307	C	G	148809307	3	3	13	1	0	0	0	0	1	0	0	0	17955	913	32	2	2040	2	ZNF425	7	148809307	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		148809307	10329356	33	904										
TNKS	8658	broad.mit.edu	37	chr8	9588536	9588536	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cggtgccgatgtccatgccaAagacaaggggtacgtgttag	14	9	0	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr8:9588536A>C	ENST00000310430.6	+	14	2164	c.2138A>C	c.(2137-2139)aAa>aCa	p.K713T	TNKS_ENST00000518281.1_Missense_Mutation_p.K476T	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	713					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		GTCCATGCCAAAGACAAGGGG	0.438													7	31					0	0	1	0	0	C	9588536	A	C	9588536	3	2	13	1	0	0	0	0	1	0	0	0	16378	14	1	4	2192	4	TNKS	8	9588536	Missense_Mutation	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08		9588536	136775486	34	905										
POLR3D	661	broad.mit.edu	37	chr8	22106726	22106726	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctgcagctgccagacaccctCcctggccagccacccaccca	7	22	0	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr8:22106726C>G	ENST00000397802.4	+	6	1040	c.825C>G	c.(823-825)ctC>ctG	p.L275L	POLR3D_ENST00000306433.4_Silent_p.L275L			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	275					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CAGACACCCTCCCTGGCCAGC	0.597													9	49					0	0	1	0	0	G	22106726	C	G	22106726	2	3	13	1	0	0	0	0	0	0	0	1	12278	842	30	2		2	POLR3D	8	22106726	Silent	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	12518190	22106726	124257296	35	906										
PXDNL	137902	broad.mit.edu	37	chr8	52320720	52320720	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	aattacagaaaactctgaagTcaacatatggtgggatcccg	9	8	2	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr8:52320720T>A	ENST00000356297.4	-	17	3564	c.3464A>T	c.(3463-3465)gAc>gTc	p.D1155V	PXDNL_ENST00000543296.1_Missense_Mutation_p.D1155V	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1155					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AACTCTGAAGTCAACATATGG	0.433													24	85					0	0	1	0	0	A	52320720	T	A	52320720	3	1	13	1	0	0	0	0	1	0	0	0	12899	1667	58	4	955	4	PXDNL	8	52320720	Missense_Mutation	SNP	T	TCGA-N5-A59E-01A-11D-A28R-08	30213994	52320720	94043302	36	907										
FRMD3	257019	broad.mit.edu	37	chr9	85924485	85924485	+	Frame_Shift_Del	DEL	A	A	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gttttccactccacacttccAaagatgtttgcaggcagctg							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr9:85924485delA	ENST00000304195.3	-	10	1098	c.892delT	c.(892-894)ggfs	p.W298fs	FRMD3_ENST00000376438.1_Frame_Shift_Del_p.W298fs|FRMD3_ENST00000376434.1_Frame_Shift_Del_p.W104fs	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	298	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CCACACTTCCAAAGATGTTTG	0.338													9	9	---	---	---	---						-	85924485	A	-	85924485	7	5	13	1	0	1	0	1	0	0	0	0	6084	130	5	0	921	0	FRMD3	9	85924485	Frame_Shift_Del	DEL	A	TCGA-N5-A59E-01A-11D-A28R-08		85924485	55288946	37	908										
KRTAP5-5	439915	broad.mit.edu	37	chr11	1651251	1651251	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gctgtgggggatgtggctccGgctgctgtgtgcctgtctgc	18	10	1	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:1651251G>A	ENST00000399676.2	+	1	219	c.181G>A	c.(181-183)Ggc>Agc	p.G61S		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	61						keratin filament		p.G61S(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		atgtggctccggctgCTGTGT	0.682													92	34					0	0	1	0	0	A	1651251	G	A	1651251	3	1	13	1	0	0	0	0	1	0	0	0	8602	1116	39	1	183	1	KRTAP5-5	11	1651251	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		1651251	133355265	38	909										
MRVI1	10335	broad.mit.edu	37	chr11	10625994	10625996	+	In_Frame_Del	DEL	CTC	CTC	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tccagttctttctcagtgttCtcctctgtcaggttgcgttc							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:10625994_10625996delCTC	ENST00000547195.1	-	12	1926_1928	c.1426_1428delGAG	c.(1426-1428)del	p.E476del	MRVI1_ENST00000527509.2_In_Frame_Del_p.E476del|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000531107.1_In_Frame_Del_p.E559del|MRVI1_ENST00000558540.1_In_Frame_Del_p.E252del|MRVI1_ENST00000424001.1_In_Frame_Del_p.E252del|MRVI1_ENST00000552103.1_In_Frame_Del_p.E476del|MRVI1_ENST00000421747.1_In_Frame_Del_p.E558del|MRVI1_ENST00000534266.2_In_Frame_Del_p.E252del|MRVI1_ENST00000545852.1_In_Frame_Del_p.E252del|MRVI1_ENST00000436272.1_In_Frame_Del_p.E540del|MRVI1_ENST00000541483.1_In_Frame_Del_p.E361del|MRVI1_ENST00000423302.2_In_Frame_Del_p.E567del	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	540					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TCTCAGTGTTCTCCTCTGTCAGG	0.473													45	13	---	---	---	---						-	10625996	CTC	-	10625994	7	5	13	1	0	1	0	1	0	0	0	0	9901	912	32	0	1073	0	MRVI1	11	10625994	In_Frame_Del	DEL	CTC	TCGA-N5-A59E-01A-11D-A28R-08	8974743	10625994	124380522	39	910										
PRDM11	56981	broad.mit.edu	37	chr11	45203391	45203391	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tatggtgacggtggtgaagaCggaggtctgctcaccactcc	14	10	2	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:45203391C>G	ENST00000263765.4	+	3	425	c.176C>G	c.(175-177)aCg>aGg	p.T59R	PRDM11_ENST00000530656.1_Missense_Mutation_p.T59R|PRDM11_ENST00000424263.2_Missense_Mutation_p.T25R			Q9NQV5	PRD11_HUMAN	PR domain containing 11	59				KTEVCSPLRD -> NPS (in Ref. 1; AAF87244).						endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						GTGGTGAAGACGGAGGTCTGC	0.622													33	7					0	0	1	0	0	G	45203391	C	G	45203391	3	3	13	1	0	0	0	0	1	0	0	0	12503	536	19	5	182	5	PRDM11	11	45203391	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	34577397	45203391	89803125	40	911										
OR4C12	283093	broad.mit.edu	37	chr11	50003362	50003362	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	acacctcccctccaagctatTgttctttaaagatctcaaga	4	13	2	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:50003362T>G	ENST00000335238.4	-	1	709	c.676A>C	c.(676-678)Aat>Cat	p.N226H		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						TCCAAGCTATTGTTCTTTAAA	0.408													7	42					0	0	1	0	0	G	50003362	T	G	50003362	3	3	13	1	0	0	0	0	1	0	0	0	11093	1812	63	4	257	4	OR4C12	11	50003362	Missense_Mutation	SNP	T	TCGA-N5-A59E-01A-11D-A28R-08	4799971	50003362	85003154	41	912										
ZBTB3	79842	broad.mit.edu	37	chr11	62520200	62520200	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tgacacatcagtctcttcatCagagatcacaatagcttcaa	5	11	6	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:62520200C>G	ENST00000394807.3	-	2	1212	c.1087G>C	c.(1087-1089)Gat>Cat	p.D363H		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						GTCTCTTCATCAGAGATCACA	0.577													27	35					0	0	1	0	0	G	62520200	C	G	62520200	3	3	13	1	0	0	0	0	1	0	0	0	17592	826	29	2	641	2	ZBTB3	11	62520200	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	12516838	62520200	72486316	42	913										
ANO2	57101	broad.mit.edu	37	chr12	5708651	5708651	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	caggaccatgggttctcactCatttccatgtactccggagt	9	12	2	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:5708651C>G	ENST00000546188.1	-	21	2306	c.2236_splice	c.e21+1	p.M745_splice	ANO2_ENST00000327087.8_Splice_Site_p.M744_splice|ANO2_ENST00000356134.5_Splice_Site_p.M745_splice			Q9NQ90	ANO2_HUMAN	anoctamin 2	749						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GGTTCTCACTCATTTCCATGT	0.542													18	204					0	0	1	0	0	G	5708651	C	G	5708651	5	3	13	1	0	0	0	0	0	0	1	0	691	840	29	2	788	2	ANO2	12	5708651	Splice_Site	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		5708651	128143244	43	914										
C3AR1	719	broad.mit.edu	37	chr12	8211663	8211663	+	Frame_Shift_Del	DEL	G	G	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	acggccactcgaaaggttttGctctgagacttggcgaagcg							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:8211663delG	ENST00000307637.4	-	2	1322	c.1119delC	c.(1117-1119)agfs	p.S373fs		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	373					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		GAAAGGTTTTGCTCTGAGACT	0.512													64	47	---	---	---	---						-	8211663	G	-	8211663	7	5	13	1	0	1	0	1	0	0	0	0	2219	1310	46	0	333	0	C3AR1	12	8211663	Frame_Shift_Del	DEL	G	TCGA-N5-A59E-01A-11D-A28R-08	2503012	8211663	125640232	44	915										
GPRC5A	0	broad.mit.edu	37	chr12	13061636	13061636	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	caggatgttatcgctattgaAtatattgtcctgaccatgaa	8	7	0	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:13061636A>G	ENST00000014914.5	+	2	1343	c.453A>G	c.(451-453)gaA>gaG	p.E151E	GPRC5A_ENST00000542056.1_Intron	NM_003979.3	NP_003970.1	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5, member A	151						cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	18		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	TCGCTATTGAATATATTGTCC	0.527													204	131					0	0	1	0	0	G	13061636	A	G	13061636	2	3	13	1	0	0	0	0	0	0	0	1	6764	98	4	4		4	GPRC5A	12	13061636	Silent	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	4849973	13061636	120790259	45	916										
IPO8	10526	broad.mit.edu	37	chr12	30834617	30834617	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	atgtcttcaccagttgatacAggcataataaactgccaagc	7	10	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:30834617A>T	ENST00000256079.4	-	4	796	c.458T>A	c.(457-459)cTg>cAg	p.L153Q		NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	153					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CAGTTGATACAGGCATAATAA	0.423													14	86					0	0	1	0	0	T	30834617	A	T	30834617	3	4	13	1	0	0	0	0	1	0	0	0	7841	188	7	4	2743	4	IPO8	12	30834617	Missense_Mutation	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	17772981	30834617	103017278	46	917										
ABCD2	225	broad.mit.edu	37	chr12	40012651	40012651	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	caagtcctgctagtagggtgGgcccaattgggcttgctcct	13	11	0	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:40012651G>T	ENST00000308666.3	-	1	902	c.767C>A	c.(766-768)cCc>cAc	p.P256H		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	256	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						TAGTAGGGTGGGCCCAATTGG	0.448													55	51					1.39843e-22	1.59227e-22	1	1	0	T	40012651	G	T	40012651	3	4	13	1	0	0	0	0	1	0	0	0	61	1232	43	5	1495	5	ABCD2	12	40012651	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	9178034	40012651	93839244	47	918										
ERBB3	2065	broad.mit.edu	37	chr12	56490829	56490829	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ataccttttgtgtctcttagCatatgctggccattggcagc	9	10	1	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:56490829C>T	ENST00000267101.3	+	20	2715	c.2274_splice	c.e20-1	p.H759_splice	ERBB3_ENST00000553131.1_5'UTR|ERBB3_ENST00000450146.2_Splice_Site_p.H116_splice|ERBB3_ENST00000415288.2_Splice_Site_p.H700_splice	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	759	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TGTCTCTTAGCATATGCTGGC	0.527													35	39					0	0	1	0	0	T	56490829	C	T	56490829	5	4	13	1	0	0	0	0	0	0	1	0	5236	724	25	3	2484	3	ERBB3	12	56490829	Splice_Site	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	16478178	56490829	77361066	48	919										
LIN7A	8825	broad.mit.edu	37	chr12	81239693	81239693	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gagggtgggagtggccttcaCtagctgcaaaagctgcaact	14	9	1	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:81239693C>A	ENST00000552864.1	-	4	501	c.299G>T	c.(298-300)aGt>aTt	p.S100I		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	100					exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						GTGGCCTTCACTAGCTGCAAA	0.408													18	0					9.16793e-09	1.00411e-08	1	1	0	A	81239693	C	A	81239693	3	1	13	1	0	0	0	0	1	0	0	0	8850	565	20	5	410	5	LIN7A	12	81239693	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	24748864	81239693	52612202	49	920										
KDM2B	84678	broad.mit.edu	37	chr12	121947777	121947777	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctgaggctgctgatcacaggCctcctcctccatctccagcc	8	18	2	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:121947777C>T	ENST00000377069.4	-	11	1553	c.1147G>A	c.(1147-1149)Gcc>Acc	p.A383T	KDM2B_ENST00000377071.4_Missense_Mutation_p.A414T|KDM2B_ENST00000538046.2_Missense_Mutation_p.A324T|KDM2B_ENST00000536437.1_Missense_Mutation_p.A297T	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	414					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TGATCACAGGCCTCCTCCTCC	0.627													27	4					0	0	1	0	0	T	121947777	C	T	121947777	3	4	13	1	0	0	0	0	1	0	0	0	8168	739	26	3	2874	3	KDM2B	12	121947777	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	40708084	121947777	11904118	50	921										
TMTC4	84899	broad.mit.edu	37	chr13	101266664	101266664	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cacgcattcaaggcatccacGtggcgattgagatctgcata	10	11	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr13:101266664G>A	ENST00000342624.5	-	16	2115	c.1857C>T	c.(1855-1857)caC>caT	p.H619H	TMTC4_ENST00000376234.3_Silent_p.H600H|TMTC4_ENST00000328767.5_Silent_p.H489H	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	600						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGGCATCCACGTGGCGATTGA	0.413													10	93					0	0	1	0	0	A	101266664	G	A	101266664	2	1	13	1	0	0	0	0	0	0	0	1	16322	1136	40	1		1	TMTC4	13	101266664	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		101266664	13903214	51	922										
MCF2L	23263	broad.mit.edu	37	chr13	113748841	113748841	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctcttaggttggagcaaaacGtcccactcactggaggcacc	10	13	2	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr13:113748841G>T	ENST00000397030.1	+	27	3103	c.3066G>T	c.(3064-3066)acG>acT	p.T1022T	MCF2L_ENST00000423482.2_Silent_p.T987T|MCF2L_ENST00000421756.1_Silent_p.T993T|MCF2L_ENST00000442652.2_Silent_p.T1019T|MCF2L_ENST00000434480.2_Silent_p.T995T|MCF2L_ENST00000375604.2_Silent_p.T1046T|MCF2L_ENST00000375601.3_Silent_p.T993T|MCF2L_ENST00000535094.2_Silent_p.T989T|MCF2L_ENST00000375608.3_Silent_p.T1019T			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	1019					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				GGAGCAAAACGTCCCACTCAC	0.622													5	39					0.000602214	0.000635364	1	1	0	T	113748841	G	T	113748841	2	4	13	1	0	0	0	0	0	0	0	1	9428	1132	40	5		5	MCF2L	13	113748841	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	12482177	113748841	1421037	52	923										
CYP1A2	1544	broad.mit.edu	37	chr15	75042815	75042815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tccccatccttcgctacctgCctaaccctgccctgcagagg	7	19	0	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr15:75042815C>T	ENST00000343932.4	+	2	799	c.736C>T	c.(736-738)Cct>Tct	p.P246S		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	246					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TCGCTACCTGCCTAACCCTGC	0.552													33	116					0	0	1	0	0	T	75042815	C	T	75042815	3	4	13	1	0	0	0	0	1	0	0	0	4173	739	26	3	738	3	CYP1A2	15	75042815	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		75042815	27488577	53	924										
ITGAD	3681	broad.mit.edu	37	chr16	31434762	31434762	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gtggctgtgtgggatgtggtCatggaggccccatctcaggt	17	8	2	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr16:31434762C>A	ENST00000389202.2	+	25	2998	c.2949C>A	c.(2947-2949)gtC>gtA	p.V983V		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	983				V -> A (in Ref. 3; AAB60638).	cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGGATGTGGTCATGGAGGCCC	0.542													106	43					1.73998e-50	2.02119e-50	1	1	0	A	31434762	C	A	31434762	2	1	13	1	0	0	0	0	0	0	0	1	7927	813	29	2		2	ITGAD	16	31434762	Silent	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		31434762	58919991	54	925										
NUP93	9688	broad.mit.edu	37	chr16	56792513	56792513	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tcccagcgattggagagtctGagtgcagccaccacctttga	11	12	1	3			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr16:56792513G>T	ENST00000569842.1	+	3	339	c.243G>T	c.(241-243)ctG>ctT	p.L81L	NUP93_ENST00000308159.5_Silent_p.L81L			Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	81					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TGGAGAGTCTGAGTGCAGCCA	0.517													11	38					0.000673444	0.000704055	1	1	0	T	56792513	G	T	56792513	2	4	13	1	0	0	0	0	0	0	0	1	10819	1277	45	2		2	NUP93	16	56792513	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	25357751	56792513	33562240	55	926										
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	accagacctcaggcggctcaTagggcaccaccacactatgt	9	15	2	1	rs121912666		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:7578190T>G	ENST00000420246.2	-	6	791	c.659A>C	c.(658-660)tAt>tCt	p.Y220S	TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.Y220S|TP53_ENST00000455263.2_Missense_Mutation_p.Y220S|TP53_ENST00000445888.2_Missense_Mutation_p.Y220S|TP53_ENST00000269305.4_Missense_Mutation_p.Y220S|TP53_ENST00000413465.2_Missense_Mutation_p.Y220S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	220	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(278)|p.Y127C(24)|p.Y220S(12)|p.?(11)|p.0?(8)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.Y127S(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*2(1)|p.V218fs*26(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	4					0	0	1	0	0	G	7578190	T	G	7578190	3	3	13	1	0	0	0	0	1	0	0	0	16441	1406	49	4	635	4	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-N5-A59E-01A-11D-A28R-08		7578190	73617020	56	927										
AZI1	22994	broad.mit.edu	37	chr17	79180597	79180597	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	acggtgcattctttcctccgCgggcccgctggtgagtcaag	13	13	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:79180597C>T	ENST00000269392.4	-	5	709	c.462G>A	c.(460-462)ccG>ccA	p.P154P	AZI1_ENST00000374782.3_Silent_p.P154P|AZI1_ENST00000575907.1_Silent_p.P154P|AZI1_ENST00000450824.2_Silent_p.P154P	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	154					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CTTTCCTCCGCGGGCCCGCTG	0.632													9	72					0	0	1	0	0	T	79180597	C	T	79180597	2	4	13	1	0	0	0	0	0	0	0	1	1238	755	27	1		1	AZI1	17	79180597	Silent	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	71602407	79180597	2014613	57	928										
NARF	26502	broad.mit.edu	37	chr17	80445875	80445875	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ggcagatggaaggcatttacGctgacatccctgtgcggcgt	14	10	0	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:80445875G>A	ENST00000390006.4	+	11	1510	c.1036G>A	c.(1036-1038)Gct>Act	p.A346T	NARF_ENST00000345415.7_Missense_Mutation_p.A357T|NARF_ENST00000309794.10_Missense_Mutation_p.A405T|NARF_ENST00000457415.3_Missense_Mutation_p.A451T	NM_001038618.2	NP_001033707.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	405						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			AGGCATTTACGCTGACATCCC	0.592													10	51					0	0	1	0	0	A	80445875	G	A	80445875	3	1	13	1	0	0	0	0	1	0	0	0	10214	1087	38	1	1397	1	NARF	17	80445875	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	1265278	80445875	749335	58	929										
PIK3C3	5289	broad.mit.edu	37	chr18	39573236	39573236	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tattgctctgtaatctaggaCggtgatgaatcatctccaat	8	8	4	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr18:39573236C>G	ENST00000262039.4	+	7	803	c.717C>G	c.(715-717)gaC>gaG	p.D239E	PIK3C3_ENST00000398870.3_Missense_Mutation_p.D176E	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	239					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						TAATCTAGGACGGTGATGAAT	0.284										TSP Lung(28;0.18)			6	31					0	0	1	0	0	G	39573236	C	G	39573236	3	3	13	1	0	0	0	0	1	0	0	0	11959	535	19	5	743	5	PIK3C3	18	39573236	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08		39573236	38504012	59	930										
MYBPC2	4606	broad.mit.edu	37	chr19	50964799	50964799	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctccctgtccccacactagGagtggttcaacgtctatgaa	8	14	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:50964799G>A	ENST00000357701.5	+	25	2983	c.2931_splice	c.e25-1	p.E978_splice		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	978	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCCACACTAGGAGTGGTTCAA	0.512											OREG0025636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					0	0	1	0	0	A	50964799	G	A	50964799	5	1	13	1	0	0	0	0	0	0	1	0	10059	1188	41	3	3030	3	MYBPC2	19	50964799	Splice_Site	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		50964799	8164184	60	931										
KLK2	3817	broad.mit.edu	37	chr19	51381707	51381707	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	aatggtgtgcttcaaggtatCacatcatggggccctgagcc	12	10	3	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:51381707C>G	ENST00000325321.3	+	5	903	c.678C>G	c.(676-678)atC>atG	p.I226M	KLK2_ENST00000391810.2_Missense_Mutation_p.I124M|KLK2_ENST00000358049.4_3'UTR			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	226	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		TTCAAGGTATCACATCATGGG	0.532			T	ETV4	prostate								54	103					0	0	1	0	0	G	51381707	C	G	51381707	3	3	13	1	0	0	0	0	1	0	0	0	8446	816	29	2	733	2	KLK2	19	51381707	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	416908	51381707	7747276	61	932										
FPR2	2358	broad.mit.edu	37	chr19	52272749	52272749	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tctatggcaagtacaaaatcAttgacatcctggttaaccca	6	10	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:52272749A>T	ENST00000598776.1	+	2	1610	c.838A>T	c.(838-840)Att>Ttt	p.I280F	FPR2_ENST00000340023.6_Missense_Mutation_p.I280F|FPR2_ENST00000598953.1_Missense_Mutation_p.I280F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	280					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						GTACAAAATCATTGACATCCT	0.498													13	45					0	0	1	0	0	T	52272749	A	T	52272749	3	4	13	1	0	0	0	0	1	0	0	0	6072	217	8	4	840	4	FPR2	19	52272749	Missense_Mutation	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	891042	52272749	6856234	62	933										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715971	52715971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctgtgctcagatgacacccCcatggtgcggcgggccgcag	14	15	1	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:52715971C>G	ENST00000322088.6	+	5	594	c.536C>G	c.(535-537)cCc>cGc	p.P179R	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124R|PPP2R1A_ENST00000462990.1_5'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612			Mis		clear cell ovarian carcinoma								13	38					0	0	1	0	0	G	52715971	C	G	52715971	3	3	13	1	0	0	0	0	1	0	0	0	12430	623	22	5	554	5	PPP2R1A	19	52715971	Missense_Mutation	SNP	C	TCGA-N5-A59E-01A-11D-A28R-08	443222	52715971	6413012	63	934										
SSTR4	6754	broad.mit.edu	37	chr20	23016960	23016960	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctttctacgtggtgcagctGctgaacctcttcgtgaccag	10	13	2	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:23016960G>C	ENST00000255008.3	+	1	904	c.840G>C	c.(838-840)ctG>ctC	p.L280L	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	280					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGGTGCAGCTGCTGAACCTCT	0.572													20	128					0	0	1	0	0	C	23016960	G	C	23016960	2	2	13	1	0	0	0	0	0	0	0	1	15255	1306	46	5		5	SSTR4	20	23016960	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		23016960	40008560	64	935										
SNTA1	6640	broad.mit.edu	37	chr20	31996508	31996508	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	gaggcagcccctcactcacgAtctcgccttcagcacctcca	7	19	4	0			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:31996508A>T	ENST00000217381.2	-	7	1695	c.1425_splice	c.e7+1	p.I475_splice		NM_003098.2	NP_003089.1	Q13424	SNTA1_HUMAN	syntrophin, alpha 1	475	SU.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			breast(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(1)	13						CTCACTCACGATCTCGCCTTC	0.622													6	226					0	0	1	0	0	T	31996508	A	T	31996508	5	4	13	1	0	0	0	0	0	0	1	0	14924	347	12	4	101	4	SNTA1	20	31996508	Splice_Site	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	8979548	31996508	31029012	65	936										
SAMHD1	25939	broad.mit.edu	37	chr20	35545400	35545400	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	caatgccatttcttttattaGatactatctcataaaggaag	5	7	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:35545400G>C	ENST00000262878.4	-	8	1104	c.905C>G	c.(904-906)tCt>tGt	p.S302C	SAMHD1_ENST00000373694.5_Missense_Mutation_p.S87C	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	302	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity	p.S302Y(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TCTTTTATTAGATACTATCTC	0.363													18	25					0	0	1	0	0	C	35545400	G	C	35545400	3	2	13	1	0	0	0	0	1	0	0	0	13879	942	33	2	1011	2	SAMHD1	20	35545400	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	3548892	35545400	27480120	66	937										
ZNF335	63925	broad.mit.edu	37	chr20	44592260	44592260	+	Frame_Shift_Del	DEL	A	A	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	tgcggcacaggaagggcctcAaaagtggtttgggcgacttg							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:44592260delA	ENST00000322927.2	-	9	1485	c.1385delT	c.(1384-1386)tgfs	p.L462fs	ZNF335_ENST00000426788.1_Frame_Shift_Del_p.L307fs	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GAAGGGCCTCAAAAGTGGTTT	0.577													30	308	---	---	---	---						-	44592260	A	-	44592260	7	5	13	1	0	1	0	1	0	0	0	0	17908	131	5	0	2723	0	ZNF335	20	44592260	Frame_Shift_Del	DEL	A	TCGA-N5-A59E-01A-11D-A28R-08	9046860	44592260	18433260	67	938										
BAGE2	85319	broad.mit.edu	37	chr21	11055420	11055420	+	RNA	DEL	G	G	-													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	agtcaactatcacagctactGctctgccctttaggaagcaa							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr21:11055420delG	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		cacagctactgctctgccctt	0.308													2	4	---	---	---	---						-	11055420	G	-	11055420	6	5	13	0	1	1	0	1	0	0	0	0	1290	1334	46	0		0	BAGE2	21	11055420	RNA	DEL	G	TCGA-N5-A59E-01A-11D-A28R-08		11055420	37074475	68	939										
BAGE2	85319	broad.mit.edu	37	chr21	11064287	11064288	+	RNA	INS	-	-	A													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ctcctccctgcttccacagcINSaatctttctaaaggaataca					rs55767427		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr21:11064287_11064288insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTTCCACAGCAATCTTTCTAA	0.416													4	6	---	---	---	---						A	11064288	-	A	11064287	6	5	13	0	1	1	1	0	0	0	0	0	1290	725	25	0		0	BAGE2	21	11064287	RNA	INS	-	TCGA-N5-A59E-01A-11D-A28R-08	8867	11064287	37065608	69	940										
LIMK2	3985	broad.mit.edu	37	chr22	31658195	31658195	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cgcatcctggagatcaatggGacccccgtccgcacacttcg	10	16	1	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:31658195G>A	ENST00000331728.4	+	6	741	c.627G>A	c.(625-627)ggG>ggA	p.G209G	LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000333611.4_Silent_p.G188G|LIMK2_ENST00000406516.1_Silent_p.G131G|LIMK2_ENST00000340552.4_Silent_p.G188G	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	209	PDZ.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						AGATCAATGGGACCCCCGTCC	0.557													27	91					0	0	1	0	0	A	31658195	G	A	31658195	2	1	13	1	0	0	0	0	0	0	0	1	8841	1161	41	3		3	LIMK2	22	31658195	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		31658195	19646371	70	941										
BRD1	23774	broad.mit.edu	37	chr22	50216636	50216636	+	Silent	SNP	G	G	A													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	aggagcgcacacggtcggcaGgaccgcgcagggctcagcca							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:50216636G>A	ENST00000216267.8	-	1	1816	c.1330C>T	c.(1330-1332)Ctg>Ttg	p.L444L	BRD1_ENST00000404034.1_Silent_p.L444L|BRD1_ENST00000542442.1_Silent_p.L83L|BRD1_ENST00000342989.5_5'UTR|BRD1_ENST00000457780.2_Silent_p.L444L|BRD1_ENST00000404760.1_Silent_p.L444L|BRD1_ENST00000459821.1_5'UTR	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	444					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		ACGGTCGGCAGGACCGCGCAG	0.572													56	117					0	0	1	0	0	A	50216636	G	A	50216636	2	1	13	1	0	0	0	0	0	0	0	1	1503	991	35	3		3	BRD1	22	50216636	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	18558441	50216636	1087930	71	942	6	2								
BRD1	23774	broad.mit.edu	37	chr22	50216637	50216637	+	Silent	SNP	G	G	T													0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	ggagcgcacacggtcggcagGaccgcgcagggctcagccag							TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:50216637G>T	ENST00000216267.8	-	1	1815	c.1329C>A	c.(1327-1329)gtC>gtA	p.V443V	BRD1_ENST00000404034.1_Silent_p.V443V|BRD1_ENST00000542442.1_Silent_p.V82V|BRD1_ENST00000342989.5_5'UTR|BRD1_ENST00000457780.2_Silent_p.V443V|BRD1_ENST00000404760.1_Silent_p.V443V|BRD1_ENST00000459821.1_5'UTR	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	443					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CGGTCGGCAGGACCGCGCAGG	0.567													56	119					7.34454e-26	8.44623e-26	1	1	0	T	50216637	G	T	50216637	2	4	13	1	0	0	0	0	0	0	0	1	1503	1161	41	2		2	BRD1	22	50216637	Silent	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	1	50216637	1087929	72	943	6	2								
ZXDB	158586	broad.mit.edu	37	chrX	57619818	57619818	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	taggctgaaaattcacctgcGgagtcacaccggcgagagac	12	11	2	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:57619818G>A	ENST00000374888.1	+	1	1550	c.1337G>A	c.(1336-1338)cGg>cAg	p.R446Q		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	446	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						ATTCACCTGCGGAGTCACACC	0.488													18	47					0	0	1	0	0	A	57619818	G	A	57619818	3	1	13	1	0	0	0	0	1	0	0	0	18290	1116	39	1	1339	1	ZXDB	23	57619818	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08		57619818	97650742	73	944										
RLIM	51132	broad.mit.edu	37	chrX	73811853	73811853	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	cctttccatatttcgatttgAgactgagccagtaggctctg	9	10	1	2			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:73811853A>C	ENST00000332687.6	-	4	1515	c.1297T>G	c.(1297-1299)Tca>Gca	p.S433A	RLIM_ENST00000349225.2_Missense_Mutation_p.S433A	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	433	Ser-rich.				random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTCGATTTGAGACTGAGCCA	0.458													28	12					0	0	1	0	0	C	73811853	A	C	73811853	3	2	13	1	0	0	0	0	1	0	0	0	13441	304	11	4	581	4	RLIM	23	73811853	Missense_Mutation	SNP	A	TCGA-N5-A59E-01A-11D-A28R-08	16192035	73811853	81458707	74	945										
GPR112	139378	broad.mit.edu	37	chrX	135475715	135475715	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0945945945945946	7	1	1.31558185404339	2.93186813186813	0.30540293040293	0.0572755417956657	0.651583710407241	0	attatggtcaagttcactgtGccttttgggattttgagaat	10	5	2	1			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:135475715G>A	ENST00000394143.1	+	18	8347	c.8056G>A	c.(8056-8058)Gcc>Acc	p.A2686T	GPR112_ENST00000394141.1_Missense_Mutation_p.A2481T|GPR112_ENST00000370652.1_Missense_Mutation_p.A2686T|GPR112_ENST00000287534.4_Missense_Mutation_p.A2439T|GPR112_ENST00000412101.1_Missense_Mutation_p.A2481T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2686	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AGTTCACTGTGCCTTTTGGGA	0.358													3	8					0	0	1	0	0	A	135475715	G	A	135475715	3	1	13	1	0	0	0	0	1	0	0	0	6668	1319	46	3	8114	3	GPR112	23	135475715	Missense_Mutation	SNP	G	TCGA-N5-A59E-01A-11D-A28R-08	61663862	135475715	19794845	75	946										
AGRN	375790	broad.mit.edu	37	chr1	985881	985881	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gctctacaacgggcagaagaCggacggcaagggggacttcg	16	10	1	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:985881C>G	ENST00000379370.2	+	29	5101	c.5051C>G	c.(5050-5052)aCg>aGg	p.T1684R		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1684	Laminin G-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGGCAGAAGACGGACGGCAAG	0.692													11	117					0	0	1	0	0	G	985881	C	G	985881	3	3	14	1	0	0	0	0	1	0	0	0	394	536	19	5	5165	5	AGRN	1	985881	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		985881	248264740	1	947										
CASZ1	54897	broad.mit.edu	37	chr1	10699155	10699156	+	In_Frame_Ins	INS	-	-	TCG													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ggtcctcgtcgtcgtcgtccINStcgtcgtcgtcctcgtcgtc							TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:10699155_10699156insTCG	ENST00000377022.3	-	21	5440_5441	c.5123_5124insCGA	c.(5122-5124)gga>gCGAga	p.1708_1708G>AR		NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1708	Asp-rich.|Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		cgtcgtcgtcctcgtcgtcgtc	0.743													5	9	---	---	---	---						TCG	10699156	-	TCG	10699155	7	5	14	1	0	1	1	0	0	0	0	0	2703	680	24	0	159	0	CASZ1	1	10699155	In_Frame_Ins	INS	-	TCGA-N5-A59F-01A-11D-A28R-08	9713274	10699155	238551466	2	948										
PRAMEF17	391004	broad.mit.edu	37	chr1	13716936	13716936	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gtggaggactatccaaggacGggagagcaccagcccttgaa	14	10	0	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:13716936G>A	ENST00000376098.4	+	2	449	c.423G>A	c.(421-423)acG>acA	p.T141T		NM_001099851.1	NP_001093321.1	Q5VTA0	PRA17_HUMAN	PRAME family member 17	141										kidney(1)|lung(2)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;9.86e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|COAD - Colon adenocarcinoma(227;0.000502)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATCCAAGGACGGGAGAGCACC	0.532													8	306					0	0	1	0	0	A	13716936	G	A	13716936	2	1	14	1	0	0	0	0	0	0	0	1	12480	1103	39	1		1	PRAMEF17	1	13716936	Silent	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	3017781	13716936	235533685	3	949										
BAI2	576	broad.mit.edu	37	chr1	32221719	32221719	+	Frame_Shift_Del	DEL	C	C	-													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gggtgtgggcagcaggagggCctggagatgtggtggtggtg							TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:32221719delC	ENST00000373658.3	-	4	1060	c.719delG	c.(718-720)gcfs	p.G240fs	BAI2_ENST00000527361.1_Frame_Shift_Del_p.G240fs|BAI2_ENST00000398538.1_Frame_Shift_Del_p.G228fs|BAI2_ENST00000398542.1_Frame_Shift_Del_p.G228fs|BAI2_ENST00000398547.1_Frame_Shift_Del_p.G228fs|BAI2_ENST00000373655.2_Frame_Shift_Del_p.G240fs|BAI2_ENST00000257070.4_Frame_Shift_Del_p.G240fs|BAI2_ENST00000398556.3_Frame_Shift_Del_p.G243fs	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	240					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AGCAGGAGGGCCTGGAGATGT	0.701													26	79	---	---	---	---						-	32221719	C	-	32221719	7	5	14	1	0	1	0	1	0	0	0	0	1297	739	26	0	4158	0	BAI2	1	32221719	Frame_Shift_Del	DEL	C	TCGA-N5-A59F-01A-11D-A28R-08	18504783	32221719	217028902	4	950										
CSMD2	114784	broad.mit.edu	37	chr1	34180304	34180304	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gaaggtcaaggtgtcgcccaCgccaaactgcaagcccttcc	10	15	1	0	rs141181841	byFrequency	TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:34180304C>T	ENST00000373381.4	-	21	3465	c.3289G>A	c.(3289-3291)Gtg>Atg	p.V1097M		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1057						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGTCGCCCACGCCAAACTGC	0.662													139	67					0	0	1	0	0	T	34180304	C	T	34180304	3	4	14	1	0	0	0	0	1	0	0	0	3970	536	19	1	7490	1	CSMD2	1	34180304	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	1958585	34180304	215070317	5	951										
LHX8	431707	broad.mit.edu	37	chr1	75608914	75608914	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tgctttgcctgcttttcctgCaaaaggcaactttccacagg	8	12	0	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:75608914C>A	ENST00000294638.5	+	6	1165	c.501C>A	c.(499-501)tgC>tgA	p.C167*	LHX8_ENST00000356261.3_Nonsense_Mutation_p.C157*	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	167	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						GCTTTTCCTGCAAAAGGCAAC	0.478													4	89					0.00024832	0.000260258	1	1	0	A	75608914	C	A	75608914	4	1	14	1	0	0	0	0	0	1	0	0	8815	718	25	5	519	5	LHX8	1	75608914	Nonsense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	41428610	75608914	173641707	6	952										
AMY2B	280	broad.mit.edu	37	chr1	104122106	104122106	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tccatttattgcaattcatgCtgaatctaaattataaaatt	3	6	2	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:104122106C>A	ENST00000361355.4	+	12	2136	c.1520C>A	c.(1519-1521)gCt>gAt	p.A507D	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	507					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GCAATTCATGCTGAATCtaaa	0.294													27	310					6.32553e-13	7.25771e-13	1	1	0	A	104122106	C	A	104122106	3	1	14	1	0	0	0	0	1	0	0	0	591	797	28	5	1558	5	AMY2B	1	104122106	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	28513192	104122106	145128515	7	953										
INSRR	3645	broad.mit.edu	37	chr1	156815523	156815523	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aggtgggtgctggcaagggcAgcagtcggactccatctcgg	17	10	1	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:156815523A>G	ENST00000368195.3	-	10	2458	c.2062T>C	c.(2062-2064)Tgc>Cgc	p.C688R	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	688					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGCAAGGGCAGCAGTCGGAC	0.632													20	76					0	0	1	0	0	G	156815523	A	G	156815523	3	3	14	1	0	0	0	0	1	0	0	0	7817	188	7	4	1882	4	INSRR	1	156815523	Missense_Mutation	SNP	A	TCGA-N5-A59F-01A-11D-A28R-08	52693417	156815523	92435098	8	954										
FCRL2	79368	broad.mit.edu	37	chr1	157739929	157739929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gctggcagtcagcacaggacGttgaaagagctctagagaga	14	8	2	4	rs139872242		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:157739929G>A	ENST00000361516.3	-	4	370	c.322C>T	c.(322-324)Cgt>Tgt	p.R108C	FCRL2_ENST00000392274.3_Missense_Mutation_p.R108C|FCRL2_ENST00000368181.4_Intron	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	108					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCACAGGACGTTGAAAGAGC	0.527													38	30					0	0	1	0	0	A	157739929	G	A	157739929	3	1	14	1	0	0	0	0	1	0	0	0	5827	1145	40	1	1240	1	FCRL2	1	157739929	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	924406	157739929	91510692	9	955										
ASPM	259266	broad.mit.edu	37	chr1	197060125	197060125	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	caatctttttgatgctatgaTatttctgaataaatctcttt	4	6	3	3			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:197060125T>A	ENST00000367409.4	-	23	9747	c.9491A>T	c.(9490-9492)tAt>tTt	p.Y3164F	ASPM_ENST00000294732.7_Missense_Mutation_p.Y1579F|ASPM_ENST00000367408.1_Missense_Mutation_p.Y829F	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3164					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						GATGCTATGATATTTCTGAAT	0.343													6	44					0	0	1	0	0	A	197060125	T	A	197060125	3	1	14	1	0	0	0	0	1	0	0	0	1055	1406	49	4	966	4	ASPM	1	197060125	Missense_Mutation	SNP	T	TCGA-N5-A59F-01A-11D-A28R-08	39320196	197060125	52190496	10	956										
OR2T27	403239	broad.mit.edu	37	chr1	248813672	248813672	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gaagaagtggttgatctcccGagaggcacagaaggggaact	15	7	1	4			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr1:248813672G>C	ENST00000344889.3	-	1	513	c.514C>G	c.(514-516)Cgg>Ggg	p.R172G		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGATCTCCCGAGAGGCACAG	0.557													15	127					0	0	1	0	0	C	248813672	G	C	248813672	3	2	14	1	0	0	0	0	1	0	0	0	11068	1057	37	2	442	2	OR2T27	1	248813672	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	51753547	248813672	436949	11	957										
ASAP2	8853	broad.mit.edu	37	chr2	9519169	9519169	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ctcaagttgctcctgcggggGaaggcctccatcgagatagg	14	11	1	1	rs35776705		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr2:9519169G>C	ENST00000281419.3	+	19	2269	c.1929G>C	c.(1927-1929)ggG>ggC	p.G643G	ASAP2_ENST00000315273.4_Silent_p.G643G	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	643					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						TCCTGCGGGGGAAGGCCTCCA	0.642													8	33					0	0	1	0	0	C	9519169	G	C	9519169	2	2	14	1	0	0	0	0	0	0	0	1	1010	1161	41	2		2	ASAP2	2	9519169	Silent	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		9519169	233680204	12	958										
RIF1	55183	broad.mit.edu	37	chr2	152311546	152311546	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aagcacattctgataccctcTtcactattggcaactcaatc	4	13	4	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr2:152311546T>C	ENST00000243326.4	+	21	2965	c.2482T>C	c.(2482-2484)Ttc>Ctc	p.F828L	RIF1_ENST00000444746.2_Missense_Mutation_p.F828L|RIF1_ENST00000453091.2_Missense_Mutation_p.F828L|RIF1_ENST00000428287.2_Missense_Mutation_p.F828L|RIF1_ENST00000430328.2_Missense_Mutation_p.F828L			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	828					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TGATACCCTCTTCACTATTGG	0.383													59	97					0	0	1	0	0	C	152311546	T	C	152311546	3	2	14	1	0	0	0	0	1	0	0	0	13408	1609	56	4	2564	4	RIF1	2	152311546	Missense_Mutation	SNP	T	TCGA-N5-A59F-01A-11D-A28R-08	142792377	152311546	90887827	13	959										
TTN	7273	broad.mit.edu	37	chr2	179569235	179569235	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tcataagccttttctaacttAccaattacagttagtttagc	4	9	2	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr2:179569235A>G	ENST00000589042.1	-	105	30187		c.e105+1		TTN_ENST00000591111.1_Splice_Site|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Splice_Site	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTAACTTACCAATTACAG	0.378													30	39					0	0	1	0	0	G	179569235	A	G	179569235	5	3	14	1	0	0	0	0	0	0	1	0	16796	405	14	4	74597	4	TTN	2	179569235	Splice_Site	SNP	A	TCGA-N5-A59F-01A-11D-A28R-08	27257689	179569235	63630138	14	960										
FARP2	9855	broad.mit.edu	37	chr2	242371190	242371193	+	Splice_Site	DEL	GTAA	GTAA	-													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aacttcatccagaggttcatGtaagtattattttcaacttt							TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr2:242371190_242371193delGTAA	ENST00000264042.3	+	9	1037		c.e9+1		FARP2_ENST00000373287.4_Splice_Site|FARP2_ENST00000545004.1_Splice_Site	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2						axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		AGAGGTTCATGTAAGTATTATTTT	0.333													7	44	---	---	---	---						-	242371193	GTAA	-	242371190	8	5	14	1	0	1	0	1	0	0	1	0	5709	1391	48	0	898	0	FARP2	2	242371190	Splice_Site	DEL	GTAA	TCGA-N5-A59F-01A-11D-A28R-08	62801955	242371190	828183	15	961										
FANCD2	2177	broad.mit.edu	37	chr3	10142903	10142903	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	agacgaagtaagtgctggagAaaaggagcaagatagtgatg	15	3	0	4			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr3:10142903A>G	ENST00000419585.1	+	44	4474	c.4313A>G	c.(4312-4314)gAa>gGa	p.E1438G	FANCD2_ENST00000383807.1_Missense_Mutation_p.E1438G|FANCD2_ENST00000383806.1_3'UTR|FANCD2OS_ENST00000524279.1_Intron			Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	0					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGTGCTGGAGAAAAGGAGCAA	0.428			"D, Mis, N, F"			"AML, leukemia"		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	75					0	0	1	0	0	G	10142903	A	G	10142903	3	3	14	1	0	0	0	0	1	0	0	0	5697	246	9	4	4618	4	FANCD2	3	10142903	Missense_Mutation	SNP	A	TCGA-N5-A59F-01A-11D-A28R-08		10142903	187879527	16	962										
HIGD1A	25994	broad.mit.edu	37	chr3	42827564	42827564	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	agccttgggctgccacacgcAtgtggatcagatgaatggac	13	10	1	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr3:42827564A>G	ENST00000321331.7	-	3	305	c.188T>C	c.(187-189)aTg>aCg	p.M63T	HIGD1A_ENST00000430190.1_Missense_Mutation_p.M63T|HIGD1A_ENST00000470543.1_5'UTR|HIGD1A_ENST00000418900.2_Missense_Mutation_p.M63T|HIGD1A_ENST00000452906.2_Missense_Mutation_p.M77T	NM_001099669.1|NM_014056.3	NP_001093139.1|NP_054775.2	Q9Y241	HIG1A_HUMAN	HIG1 hypoxia inducible domain family, member 1A	63	HIG1.				response to stress	integral to membrane|protein complex	protein binding			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TGCCACACGCATGTGGATCAG	0.383													25	35					0	0	1	0	0	G	42827564	A	G	42827564	3	3	14	1	0	0	0	0	1	0	0	0	7146	217	8	4	101	4	HIGD1A	3	42827564	Missense_Mutation	SNP	A	TCGA-N5-A59F-01A-11D-A28R-08	32684661	42827564	155194866	17	963										
MUC4	4585	broad.mit.edu	37	chr3	195508382	195508382	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gacaggaagaggggtggcgtGacctgtggatactgaggaag	19	5	0	3			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr3:195508382G>A	ENST00000463781.3	-	2	10528	c.10069C>T	c.(10069-10071)Cac>Tac	p.H3357Y	MUC4_ENST00000475231.1_Missense_Mutation_p.H3357Y|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	140					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGGTGGCGTGACCTGTGGAT	0.602													3	11					0	0	1	0	0	A	195508382	G	A	195508382	3	1	14	1	0	0	0	0	1	0	0	0	10025	1290	45	3		3	MUC4	3	195508382	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	152680818	195508382	2514048	18	964			1	3		3	3	3556	N	G_C	3.305018e-05
MUC4	4585	broad.mit.edu	37	chr3	195511678	195511678	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ctgaggaagcgtcggtgacaGgaagaggggtggtgtcacct	18	7	1	3	rs71634713		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr3:195511678G>A	ENST00000463781.3	-	2	7232	c.6773C>T	c.(6772-6774)cCt>cTt	p.P2258L	MUC4_ENST00000475231.1_Missense_Mutation_p.P2258L|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	27					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTCGGTGACAGGAAGAGGGGT	0.577													3	11					0	0	1	0	0	A	195511678	G	A	195511678	3	1	14	1	0	0	0	0	1	0	0	0	10025	1000	35	3		3	MUC4	3	195511678	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	3296	195511678	2510752	19	965			1	3		3	3	3556	N	G_C	3.305018e-05
MUC4	4585	broad.mit.edu	37	chr3	195511937	195511937	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aggaagagaggtggcgtgacCtgtggatgctgaggaagtgt	19	4	0	3			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr3:195511937C>T	ENST00000463781.3	-	2	6973	c.6514G>A	c.(6514-6516)Ggt>Agt	p.G2172S	MUC4_ENST00000475231.1_Missense_Mutation_p.G2172S|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	951					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGCGTGACCTGTGGATGCT	0.577													3	5					0	0	1	0	0	T	195511937	C	T	195511937	3	4	14	1	0	0	0	0	1	0	0	0	10025	681	24	3		3	MUC4	3	195511937	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	259	195511937	2510493	20	966			1	3		3	3	3556	N	G_C	3.305018e-05
PIGG	54872	broad.mit.edu	37	chr4	517577	517577	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	acctccgaagtgctcagaggCcgcgagaagtggatggtgct	15	10	1	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr4:517577C>A	ENST00000453061.2	+	9	2050	c.1944C>A	c.(1942-1944)ggC>ggA	p.G648G	PIGG_ENST00000310340.5_Silent_p.G640G|PIGG_ENST00000504346.1_Silent_p.G559G|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000383028.4_Silent_p.G515G	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	648					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						TGCTCAGAGGCCGCGAGAAGT	0.652													22	32					3.5997e-14	4.17412e-14	1	1	0	A	517577	C	A	517577	2	1	14	1	0	0	0	0	0	0	0	1	11935	726	26	5		5	PIGG	4	517577	Silent	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		517577	190636699	21	967										
FBXW7	0	broad.mit.edu	37	chr4	153244092	153244092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ggtttcttcagtcccattccGactcccaactgcacacacca	5	17	2	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr4:153244092G>A	ENST00000281708.4	-	12	3294	c.2065C>T	c.(2065-2067)Cgg>Tgg	p.R689W	FBXW7_ENST00000603548.1_Missense_Mutation_p.R689W|FBXW7_ENST00000393956.3_Missense_Mutation_p.R513W|FBXW7_ENST00000296555.5_Missense_Mutation_p.R571W|FBXW7_ENST00000263981.5_Missense_Mutation_p.R609W|FBXW7_ENST00000603841.1_Missense_Mutation_p.R689W	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	689					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R689W(10)|p.R450W(3)|p.R609W(3)|p.R571W(1)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GTCCCATTCCGACTCCCAACT	0.478			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								53	91					0	0	1	0	0	A	153244092	G	A	153244092	3	1	14	1	0	0	0	0	1	0	0	0	5801	1057	37	1	62	1	FBXW7	4	153244092	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	152726515	153244092	37910184	22	968										
FBXW7	0	broad.mit.edu	37	chr4	153245518	153245518	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	cacggattgatgtatcaagaGatccactcaccacatggata	8	10	2	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr4:153245518G>A	ENST00000281708.4	-	11	2902	c.1673C>T	c.(1672-1674)tCt>tTt	p.S558F	FBXW7_ENST00000603548.1_Missense_Mutation_p.S558F|FBXW7_ENST00000393956.3_Missense_Mutation_p.S382F|FBXW7_ENST00000296555.5_Missense_Mutation_p.S440F|FBXW7_ENST00000263981.5_Missense_Mutation_p.S478F|FBXW7_ENST00000603841.1_Missense_Mutation_p.S558F	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	558					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGTATCAAGAGATCCACTCAC	0.403			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								7	11					0	0	1	0	0	A	153245518	G	A	153245518	3	1	14	1	0	0	0	0	1	0	0	0	5801	942	33	3	458	3	FBXW7	4	153245518	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	1426	153245518	37908758	23	969										
ADAMTS16	170690	broad.mit.edu	37	chr5	5262848	5262848	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	cttctgcaatcccaagacacGacctgtcacggggctggtgc	11	14	2	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:5262848G>A	ENST00000274181.7	+	18	2879	c.2741G>A	c.(2740-2742)cGa>cAa	p.R914Q		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	914	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CCCAAGACACGACCTGTCACG	0.512													65	82					0	0	1	0	0	A	5262848	G	A	5262848	3	1	14	1	0	0	0	0	1	0	0	0	260	1058	37	1	2811	1	ADAMTS16	5	5262848	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		5262848	175652412	24	970										
C5orf42	65250	broad.mit.edu	37	chr5	37169474	37169474	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gccatcaccaggactaaatgTttttgcatgtgggataagtc	10	8	1	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:37169474T>C	ENST00000274258.7	-	34	6879	c.3292A>G	c.(3292-3294)Aca>Gca	p.T1098A	C5orf42_ENST00000425232.2_Missense_Mutation_p.T2218A|C5orf42_ENST00000508244.1_Missense_Mutation_p.T2218A			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2218										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GGACTAAATGTTTTTGCATGT	0.418													5	99					0	0	1	0	0	C	37169474	T	C	37169474	3	2	14	1	0	0	0	0	1	0	0	0	2316	1725	60	4	3017	4	C5orf42	5	37169474	Missense_Mutation	SNP	T	TCGA-N5-A59F-01A-11D-A28R-08	31906626	37169474	143745786	25	971										
EGFLAM	133584	broad.mit.edu	37	chr5	38406264	38406264	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aagtggccgctatggaccccGttatatcaccgacatgggag	12	11	1	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:38406264G>A	ENST00000322350.5	+	7	1095	c.749G>A	c.(748-750)cGt>cAt	p.R250H	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Missense_Mutation_p.R16H|EGFLAM_ENST00000354891.3_Missense_Mutation_p.R250H	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	250						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TATGGACCCCGTTATATCACC	0.483													33	55					0	0	1	0	0	A	38406264	G	A	38406264	3	1	14	1	0	0	0	0	1	0	0	0	4992	1145	40	1	789	1	EGFLAM	5	38406264	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	1236790	38406264	142508996	26	972										
PCDHB10	0	broad.mit.edu	37	chr5	140572948	140572948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	atgtagactctggagtcaacGcggaagtatcctattcattt	9	8	3	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:140572948G>A	ENST00000239446.4	+	1	1007	c.823G>A	c.(823-825)Gcg>Acg	p.A275T		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		275	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGAGTCAACGCGGAAGTATC	0.428													49	59					0	0	1	0	0	A	140572948	G	A	140572948	3	1	14	1	0	0	0	0	1	0	0	0	11581	1087	38	1	825	1	PCDHB10	5	140572948	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	102166684	140572948	40342312	27	973										
GRIA1	0	broad.mit.edu	37	chr5	153149777	153149777	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gtggacatacatgaagtcagCagagccatcagtttttgtgc	11	8	2	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:153149777C>A	ENST00000285900.5	+	13	2415	c.2072C>A	c.(2071-2073)gCa>gAa	p.A691E	GRIA1_ENST00000518783.1_Missense_Mutation_p.A701E|GRIA1_ENST00000518142.1_Missense_Mutation_p.A611E|GRIA1_ENST00000340592.5_Missense_Mutation_p.A691E|GRIA1_ENST00000448073.4_Missense_Mutation_p.A701E|GRIA1_ENST00000521843.2_Missense_Mutation_p.A622E	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	691					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATGAAGTCAGCAGAGCCATCA	0.473													39	123					1.66425e-11	1.87014e-11	1	1	0	A	153149777	C	A	153149777	3	1	14	1	0	0	0	0	1	0	0	0	6807	710	25	5	2122	5	GRIA1	5	153149777	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	12576829	153149777	27765483	28	974										
SQSTM1	8878	broad.mit.edu	37	chr5	179263548	179263548	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aagaactatgacatcggagcGgctctggacaccatccagta	10	11	1	2	rs143977783		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:179263548G>A	ENST00000510187.1	+	7	1044	c.1028G>A	c.(1027-1029)cGg>cAg	p.R343Q	SQSTM1_ENST00000402874.3_Silent_p.A342A|SQSTM1_ENST00000389805.4_Silent_p.A426A|C5orf45_ENST00000403396.2_3'UTR|SQSTM1_ENST00000360718.5_Silent_p.A342A|SQSTM1_ENST00000376929.3_Silent_p.A342A			Q13501	SQSTM_HUMAN	sequestosome 1	0	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACATCGGAGCGGCTCTGGACA	0.557													8	186					0	0	1	0	0	A	179263548	G	A	179263548	3	1	14	1	0	0	0	0	1	0	0	0	15185	1103	39	1	1308	1	SQSTM1	5	179263548	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	26113771	179263548	1651712	29	975										
FLT4	2324	broad.mit.edu	37	chr5	180048621	180048621	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tcgcacacatagtggccctcGtgctcgggcgcgacgcgggg	16	14	0	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr5:180048621G>A	ENST00000261937.6	-	13	2019	c.1941C>T	c.(1939-1941)caC>caT	p.H647H	FLT4_ENST00000502649.1_Silent_p.H647H|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Silent_p.H647H	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	647	Ig-like C2-type 6.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGTGGCCCTCGTGCTCGGGCG	0.687													29	36					0	0	1	0	0	A	180048621	G	A	180048621	2	1	14	1	0	0	0	0	0	0	0	1	5976	1136	40	1		1	FLT4	5	180048621	Silent	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	785073	180048621	866639	30	976										
THBS2	7058	broad.mit.edu	37	chr6	169623562	169623562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	atctttacaaatatcaccccGtccatcacctatgcacaaag	3	14	3	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr6:169623562G>A	ENST00000366787.3	-	19	3031	c.2782C>T	c.(2782-2784)Cgg>Tgg	p.R928W	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	928					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		ATATCACCCCGTCCATCACCT	0.403													4	52					0	0	1	0	0	A	169623562	G	A	169623562	3	1	14	1	0	0	0	0	1	0	0	0	15913	1144	40	1	756	1	THBS2	6	169623562	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		169623562	1491505	31	977										
WBSCR17	64409	broad.mit.edu	37	chr7	70853251	70853251	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ctcaagtactccaaggacctGccccagatatccatcatatt	5	14	2	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr7:70853251G>A	ENST00000333538.5	+	3	1087	c.453G>A	c.(451-453)ctG>ctA	p.L151L	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	151	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCAAGGACCTGCCCCAGATAT	0.542													6	66					0	0	1	0	0	A	70853251	G	A	70853251	2	1	14	1	0	0	0	0	0	0	0	1	17323	1306	46	3		3	WBSCR17	7	70853251	Silent	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		70853251	88285412	32	978										
MAGI2	9863	broad.mit.edu	37	chr7	77797376	77797376	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gctcatctcctgggtgaaggCggccatctctgtcggctgag	14	12	3	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr7:77797376C>T	ENST00000354212.4	-	15	2706	c.2453G>A	c.(2452-2454)cGc>cAc	p.R818H	MAGI2_ENST00000419488.1_Missense_Mutation_p.R804H|MAGI2_ENST00000522391.1_Missense_Mutation_p.R818H	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	818	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGGGTGAAGGCGGCCATCTCT	0.507													33	101					0	0	1	0	0	T	77797376	C	T	77797376	3	4	14	1	0	0	0	0	1	0	0	0	9240	768	27	1	1946	1	MAGI2	7	77797376	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	6944125	77797376	81341287	33	979										
GRM3	0	broad.mit.edu	37	chr7	86415593	86415593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ctaggtggcaaacctgctgcGgctcttccagatccctcaga	10	14	2	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr7:86415593G>A	ENST00000361669.2	+	3	1584	c.485G>A	c.(484-486)cGg>cAg	p.R162Q	AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.R34Q|GRM3_ENST00000394720.2_Missense_Mutation_p.R160Q|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000439827.1_Missense_Mutation_p.R162Q	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	162					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AACCTGCTGCGGCTCTTCCAG	0.522													158	37					0	0	1	0	0	A	86415593	G	A	86415593	3	1	14	1	0	0	0	0	1	0	0	0	6838	1116	39	1	491	1	GRM3	7	86415593	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	8618217	86415593	72723070	34	980										
XKR5	389610	broad.mit.edu	37	chr8	6689629	6689629	+	RNA	DEL	T	T	-													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tgcccttgatataaactcacTgacacatctcttctcatagc							TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr8:6689629delT	ENST00000518724.1	-	0	393							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		ATAAACTCACTGACACATCTC	0.408													2	4	---	---	---	---						-	6689629	T	-	6689629	6	5	14	0	1	1	0	1	0	0	0	0	17493	1595	55	0		0	XKR5	8	6689629	RNA	DEL	T	TCGA-N5-A59F-01A-11D-A28R-08		6689629	139674393	35	981										
SORBS3	10174	broad.mit.edu	37	chr8	22428688	22428688	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gggacagacctccccccgtcGcactggcttctccttcccca	8	20	1	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr8:22428688G>A	ENST00000240123.7	+	18	2080	c.1697G>A	c.(1696-1698)cGc>cAc	p.R566H	SORBS3_ENST00000428103.1_Missense_Mutation_p.R224H	NM_005775.4	NP_005766.3	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3	566					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)	18		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		TCCCCCCGTCGCACTGGCTTC	0.697													35	54					0	0	1	0	0	A	22428688	G	A	22428688	3	1	14	1	0	0	0	0	1	0	0	0	14982	1087	38	1	1763	1	SORBS3	8	22428688	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	15739059	22428688	123935334	36	982										
CDKN2B	1030	broad.mit.edu	37	chr9	22006054	22006054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ccgctcctcggccaagtccaCgggcagacgaccccaggcat	11	18	0	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr9:22006054C>T	ENST00000276925.6	-	2	758	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	CDKN2B-AS1_ENST00000428597.1_RNA|CDKN2B-AS1_ENST00000583719.1_RNA|CDKN2B-AS1_ENST00000582301.1_RNA|CDKN2B-AS1_ENST00000581051.1_RNA|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2B-AS1_ENST00000580467.1_RNA|CDKN2B-AS1_ENST00000584020.1_RNA|CDKN2B-AS1_ENST00000585267.1_RNA|CDKN2B_ENST00000380142.4_3'UTR|CDKN2B-AS1_ENST00000582072.1_RNA|CDKN2B-AS1_ENST00000455933.2_RNA|CDKN2B-AS1_ENST00000584816.1_RNA|CDKN2B-AS1_ENST00000584637.1_RNA|CDKN2B-AS1_ENST00000580576.1_RNA|CDKN2B-AS1_ENST00000468603.2_RNA|CDKN2B-AS1_ENST00000584351.1_RNA|CDKN2B-AS1_ENST00000577551.1_RNA	NM_004936.3|NM_078487.2	NP_004927.2|NP_511042.1	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	117					cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0(1)|p.0?(1)		lung(2)	2		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		GCCAAGTCCACGGGCAGACGA	0.716													12	20					0	0	1	0	0	T	22006054	C	T	22006054	3	4	14	1	0	0	0	0	1	0	0	0	3186	536	19	1	71	1	CDKN2B	9	22006054	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		22006054	119207377	37	983										
TRPM6	140803	broad.mit.edu	37	chr9	77354770	77354770	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	atcctcagaccaagtgctgaCgactctcatagctttacgga	8	12	2	2	rs142946646		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr9:77354770C>T	ENST00000451710.3	-	33	5605	c.5368G>A	c.(5368-5370)Gtc>Atc	p.V1790I	TRPM6_ENST00000449912.2_Missense_Mutation_p.V1781I|TRPM6_ENST00000376864.4_Missense_Mutation_p.V1790I|TRPM6_ENST00000376871.3_Missense_Mutation_p.V623I|TRPM6_ENST00000376872.3_Missense_Mutation_p.V741I|TRPM6_ENST00000361255.3_Missense_Mutation_p.V1781I|TRPM6_ENST00000360774.1_Missense_Mutation_p.V1786I			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1786	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CAAGTGCTGACGACTCTCATA	0.502													4	88					0	0	1	0	0	T	77354770	C	T	77354770	3	4	14	1	0	0	0	0	1	0	0	0	16650	536	19	1	736	1	TRPM6	9	77354770	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	55348716	77354770	63858661	38	984										
RALGDS	5900	broad.mit.edu	37	chr9	135985085	135985085	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	agccgtatctagaggaggccGtgagggcgtcacatctaccg	14	11	3	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr9:135985085G>A	ENST00000393160.3	-	4	700	c.347C>T	c.(346-348)aCg>aTg	p.T116M	RALGDS_ENST00000372050.3_Missense_Mutation_p.T171M|RALGDS_ENST00000542690.1_Missense_Mutation_p.T242M|RALGDS_ENST00000372047.3_Intron|RALGDS_ENST00000372062.3_Intron|RALGDS_ENST00000393157.3_Missense_Mutation_p.T170M	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	171	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity	p.T171M(1)		endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		AGAGGAGGCCGTGAGGGCGTC	0.527			T	CIITA	"PMBL, Hodgkin Lymphona, "								6	79					0	0	1	0	0	A	135985085	G	A	135985085	3	1	14	1	0	0	0	0	1	0	0	0	13067	1145	40	1	2292	1	RALGDS	9	135985085	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	58630315	135985085	5228346	39	985										
GATA3	2625	broad.mit.edu	37	chr10	8097749	8097749	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	cgcggcgcagtacccgctgcCggaggaggtggatgtgcttt	17	11	0	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr10:8097749C>T	ENST00000379328.3	+	2	699	c.131C>T	c.(130-132)cCg>cTg	p.P44L	GATA3_ENST00000346208.3_Missense_Mutation_p.P44L	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	44					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TACCCGCTGCCGGAGGAGGTG	0.662			"F, N, S"		breast		"HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"						6	9					0	0	1	0	0	T	8097749	C	T	8097749	3	4	14	1	0	0	0	0	1	0	0	0	6294	652	23	1	133	1	GATA3	10	8097749	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		8097749	127436998	40	986										
STK32C	282974	broad.mit.edu	37	chr10	134040384	134040384	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	caccgtgtcctcggagaactGcacgttctgctgcaggtggt	13	12	1	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr10:134040384G>T	ENST00000368622.1	-	4	589	c.208C>A	c.(208-210)Cag>Aag	p.Q70K	STK32C_ENST00000368625.4_Missense_Mutation_p.Q200K			Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	187							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(15)|ovary(2)|skin(1)	23		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TCGGAGAACTGCACGTTCTGC	0.622													69	64					2.02627e-32	2.37488e-32	1	1	0	T	134040384	G	T	134040384	3	4	14	1	0	0	0	0	1	0	0	0	15354	1328	46	5	937	5	STK32C	10	134040384	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	125942635	134040384	1494363	41	987										
MS4A7	58475	broad.mit.edu	37	chr11	60161317	60161317	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aacaggtcaaaaagagttctTcacggtcttggatataagta	9	6	4	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr11:60161317T>A	ENST00000358246.1	+	6	764	c.571T>A	c.(571-573)Tca>Aca	p.S191T	MS4A14_ENST00000531787.1_Intron|MS4A7_ENST00000300184.3_Missense_Mutation_p.S236T|MS4A7_ENST00000530234.2_Intron|MS4A7_ENST00000534016.1_Missense_Mutation_p.S191T	NM_206938.1|NM_206940.1	NP_996821.1|NP_996823.1	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member 7	236						integral to membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(8)|ovary(1)|skin(1)	20						AAAGAGTTCTTCACGGTCTTG	0.373													5	49					0	0	1	0	0	A	60161317	T	A	60161317	3	1	14	1	0	0	0	0	1	0	0	0	9914	1783	62	4	728	4	MS4A7	11	60161317	Missense_Mutation	SNP	T	TCGA-N5-A59F-01A-11D-A28R-08		60161317	74845199	42	988										
ZP1	22917	broad.mit.edu	37	chr11	60637224	60637224	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ctcccaaggctctggccatgCctttcccagcccactggacc	8	19	1	0	rs138582317		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr11:60637224C>T	ENST00000278853.5	+	3	533	c.533C>T	c.(532-534)gCc>gTc	p.A178V		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	178					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						TCTGGCCATGCCTTTCCCAGC	0.632													51	7					0	0	1	0	0	T	60637224	C	T	60637224	3	4	14	1	0	0	0	0	1	0	0	0	18256	739	26	3	543	3	ZP1	11	60637224	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	475907	60637224	74369292	43	989										
FOLR3	2352	broad.mit.edu	37	chr11	71847090	71847090	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	caggagtgcgcgggccaggaCggacctgctcaatgtctgca	15	12	2	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr11:71847090C>T	ENST00000445078.2	+	2	157	c.86C>T	c.(85-87)aCg>aTg	p.T29M	FOLR3_ENST00000456237.1_Missense_Mutation_p.T31M|FOLR3_ENST00000442948.2_Missense_Mutation_p.T31M			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	29					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	CGGGCCAGGACGGACCTGCTC	0.622													30	166					0	0	1	0	0	T	71847090	C	T	71847090	3	4	14	1	0	0	0	0	1	0	0	0	6015	536	19	1	94	1	FOLR3	11	71847090	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	11209866	71847090	63159426	44	990										
NOX4	50507	broad.mit.edu	37	chr11	89106611	89106611	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tctacatacctgtccagtctCctactattttaagatgaacc	4	12	2	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr11:89106611C>T	ENST00000535633.1	-	12	1362	c.1052G>A	c.(1051-1053)gGa>gAa	p.G351E	NOX4_ENST00000263317.4_Missense_Mutation_p.G375E|NOX4_ENST00000534731.1_Missense_Mutation_p.G375E|NOX4_ENST00000527626.1_Missense_Mutation_p.G209E|NOX4_ENST00000413594.2_Missense_Mutation_p.G396E|NOX4_ENST00000375979.3_Missense_Mutation_p.G68E|NOX4_ENST00000542487.1_Missense_Mutation_p.G351E|NOX4_ENST00000424319.1_Missense_Mutation_p.G351E|NOX4_ENST00000527956.1_Missense_Mutation_p.G351E|NOX4_ENST00000532825.1_Missense_Mutation_p.G351E|NOX4_ENST00000528341.1_Missense_Mutation_p.G350E|NOX4_ENST00000343727.5_Missense_Mutation_p.G351E|NOX4_ENST00000531342.1_Missense_Mutation_p.G68E|NOX4_ENST00000525196.1_Intron	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	375	FAD-binding FR-type.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity	p.G375E(1)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TGTCCAGTCTCCTACTATTTT	0.279													6	89					0	0	1	0	0	T	89106611	C	T	89106611	3	4	14	1	0	0	0	0	1	0	0	0	10604	855	30	3	640	3	NOX4	11	89106611	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	17259521	89106611	45899905	45	991										
ACRV1	56	broad.mit.edu	37	chr11	125547800	125547800	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	agaaggctgttcaccggagcCatgttcacctgaaggctgtt	12	10	2	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr11:125547800C>T	ENST00000533904.1	-	2	787	c.445G>A	c.(445-447)Ggc>Agc	p.G149S	ACRV1_ENST00000257382.2_Missense_Mutation_p.G94S|ACRV1_ENST00000425431.1_Intron|ACRV1_ENST00000453509.1_Missense_Mutation_p.G79S|ACRV1_ENST00000345274.1_Missense_Mutation_p.G79S|ACRV1_ENST00000445562.1_Missense_Mutation_p.G54S|ACRV1_ENST00000433875.1_Missense_Mutation_p.G149S|ACRV1_ENST00000353070.1_Intron|ACRV1_ENST00000426183.1_Missense_Mutation_p.G79S|ACRV1_ENST00000348856.3_Intron			P26436	ASPX_HUMAN	acrosomal vesicle protein 1	149	4 X 4 AA repeats of S-G-E-H.|9 X 5 AA repeats of [SV]-G-E-Q-[PSA].				multicellular organismal development	acrosomal vesicle				kidney(1)|large_intestine(3)|lung(2)	6	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)		TCACCGGAGCCATGTTCACCT	0.552													8	162					0	0	1	0	0	T	125547800	C	T	125547800	3	4	14	1	0	0	0	0	1	0	0	0	172	594	21	3	364	3	ACRV1	11	125547800	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	36441189	125547800	9458716	46	992										
PDE1B	0	broad.mit.edu	37	chr12	54963370	54963370	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	cctctgtgggccccacttacTctactgcggttctcaactgt	8	15	3	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr12:54963370T>G	ENST00000243052.3	+	5	887	c.451T>G	c.(451-453)Tct>Gct	p.S151A	PDE1B_ENST00000550620.1_Missense_Mutation_p.S131A|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.S110A	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	151					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						CCCCACTTACTCTACTGCGGT	0.498													10	28					0	0	1	0	0	G	54963370	T	G	54963370	3	3	14	1	0	0	0	0	1	0	0	0	11680	1551	54	4	522	4	PDE1B	12	54963370	Missense_Mutation	SNP	T	TCGA-N5-A59F-01A-11D-A28R-08		54963370	78888525	47	993										
ERBB3	2065	broad.mit.edu	37	chr12	56477655	56477655	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gaaccttgagattgtgctcaCgggacacaatgccgacctct	10	12	2	1	rs142735651		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr12:56477655C>T	ENST00000267101.3	+	2	643	c.203C>T	c.(202-204)aCg>aTg	p.T68M	ERBB3_ENST00000411731.2_Missense_Mutation_p.T68M|ERBB3_ENST00000415288.2_Missense_Mutation_p.T9M|ERBB3_ENST00000450146.2_Intron	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	68					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			ATTGTGCTCACGGGACACAAT	0.547													82	135					0	0	1	0	0	T	56477655	C	T	56477655	3	4	14	1	0	0	0	0	1	0	0	0	5236	536	19	1	209	1	ERBB3	12	56477655	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	1514285	56477655	77374240	48	994										
RPLP0	6175	broad.mit.edu	37	chr12	120637130	120637130	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gacttctccagagctgggttGttttccaggtgccctcggat	12	11	1	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr12:120637130G>A	ENST00000551150.1	-	2	528	c.213C>T	c.(211-213)aaC>aaT	p.N71N	RPLP0_ENST00000228306.4_Silent_p.N71N|RPLP0_ENST00000546989.1_Silent_p.N71N|RPLP0_ENST00000550296.1_5'UTR|RPLP0_ENST00000313104.5_Silent_p.N71N|RPLP0_ENST00000392514.4_Silent_p.N71N			P05388	RLA0_HUMAN	ribosomal protein, large, P0	71					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAGCTGGGTTGTTTTCCAGGT	0.567													51	101					0	0	1	0	0	A	120637130	G	A	120637130	2	1	14	1	0	0	0	0	0	0	0	1	13655	1368	48	3		3	RPLP0	12	120637130	Silent	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	64159475	120637130	13214765	49	995										
BRCA2	675	broad.mit.edu	37	chr13	32913905	32913905	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	atgcatacccacaaactgtaAatgaagatatttgcgttgag	8	7	0	3			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr13:32913905A>G	ENST00000544455.1	+	11	5640	c.5413A>G	c.(5413-5415)Aat>Gat	p.N1805D	BRCA2_ENST00000380152.3_Missense_Mutation_p.N1805D	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1805			N -> S.		cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ACAAACTGTAAATGAAGATAT	0.313			"D, Mis, N, F, S"		"breast, ovarian, pancreatic"	"breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			17	100					0	0	1	0	0	G	32913905	A	G	32913905	3	3	14	1	0	0	0	0	1	0	0	0	1501	14	1	4	5451	4	BRCA2	13	32913905	Missense_Mutation	SNP	A	TCGA-N5-A59F-01A-11D-A28R-08		32913905	82255973	50	996										
TSC22D1	8848	broad.mit.edu	37	chr13	45148061	45148061	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gtacagcagacactgctgccGgagcctggccaacaggctgg	14	13	0	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr13:45148061G>T	ENST00000458659.2	-	1	2640	c.2150C>A	c.(2149-2151)cCg>cAg	p.P717Q	TSC22D1_ENST00000501704.2_Intron	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	717	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CACTGCTGCCGGAGCCTGGCC	0.577													16	205					6.72482e-11	7.47965e-11	1	1	0	T	45148061	G	T	45148061	3	4	14	1	0	0	0	0	1	0	0	0	16667	1116	39	5	1212	5	TSC22D1	13	45148061	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	12234156	45148061	70021817	51	997										
NEK5	341676	broad.mit.edu	37	chr13	52661488	52661488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tttaacctgttccttcatttCgtttttcctaaatggcagct	5	10	1	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr13:52661488C>T	ENST00000355568.4	-	15	1517	c.1378G>A	c.(1378-1380)Gaa>Aaa	p.E460K		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	460							ATP binding|metal ion binding|protein serine/threonine kinase activity	p.E517K(2)|p.E460K(2)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TCCTTCATTTCGTTTTTCCTA	0.393													5	101					0	0	1	0	0	T	52661488	C	T	52661488	3	4	14	1	0	0	0	0	1	0	0	0	10373	893	31	1	780	1	NEK5	13	52661488	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	7513427	52661488	62508390	52	998										
HERC2	8924	broad.mit.edu	37	chr15	28474383	28474383	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ggcatccatcaaaacatttcGaatgttctgtacagcccaag	7	11	2	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr15:28474383G>A	ENST00000261609.7	-	34	5338	c.5230C>T	c.(5230-5232)Cga>Tga	p.R1744*		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1744					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAAACATTTCGAATGTTCTGT	0.378													23	297					0	0	1	0	0	A	28474383	G	A	28474383	4	1	14	1	0	0	0	0	0	1	0	0	7098	1066	37	1	9514	1	HERC2	15	28474383	Nonsense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		28474383	74057009	53	999										
RTF1	23168	broad.mit.edu	37	chr15	41772461	41772461	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	taagtcagccagtgacctctCagaagatctgttcaaagtac	8	10	4	3			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr15:41772461C>T	ENST00000389629.4	+	17	1976	c.1964C>T	c.(1963-1965)tCa>tTa	p.S655L		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	655					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		AGTGACCTCTCAGAAGATCTG	0.448													49	67					0	0	1	0	0	T	41772461	C	T	41772461	3	4	14	1	0	0	0	0	1	0	0	0	13772	838	29	3	2030	3	RTF1	15	41772461	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	13298078	41772461	60758931	54	1000										
ITGA11	22801	broad.mit.edu	37	chr15	68643609	68643609	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gacttacggccaccgcatatCttgttacgttgtctctttcg	8	12	2	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr15:68643609C>G	ENST00000423218.2	-	8	976	c.881G>C	c.(880-882)aGa>aCa	p.R294T	ITGA11_ENST00000315757.7_Missense_Mutation_p.R294T|ITGA11_ENST00000562826.1_5'UTR			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	294	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CACCGCATATCTTGTTACGTT	0.557													10	38					0	0	1	0	0	G	68643609	C	G	68643609	3	3	14	1	0	0	0	0	1	0	0	0	7917	913	32	2	2777	2	ITGA11	15	68643609	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	26871148	68643609	33887783	55	1001										
TP53	7157	broad.mit.edu	37	chr17	7578478	7578478	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ggacgcgggtgccgggcgggGgtgtggaatcaacccacagc	19	11	1	0	rs137852790		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr17:7578478G>C	ENST00000420246.2	-	5	584	c.452C>G	c.(451-453)cCc>cGc	p.P151R	TP53_ENST00000269305.4_Missense_Mutation_p.P151R|TP53_ENST00000413465.2_Missense_Mutation_p.P151R|TP53_ENST00000445888.2_Missense_Mutation_p.P151R|TP53_ENST00000359597.4_Missense_Mutation_p.P151R|TP53_ENST00000455263.2_Missense_Mutation_p.P151R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	151	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151H(31)|p.P151R(9)|p.0?(8)|p.P151L(7)|p.T150fs*16(6)|p.?(5)|p.P58H(2)|p.P19H(2)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.T57fs*16(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*28(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.P58R(1)|p.Q144_G154del11(1)|p.P19R(1)|p.Q144fs*16(1)|p.P152fs*14(1)|p.P151fs*30(1)|p.T18fs*16(1)|p.T150_P151delTP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGGGCGGGGGTGTGGAATC	0.607		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			52	18					0	0	1	0	0	C	7578478	G	C	7578478	3	2	14	1	0	0	0	0	1	0	0	0	16441	1232	43	5	846	5	TP53	17	7578478	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		7578478	73616732	56	1002										
MRPS7	51081	broad.mit.edu	37	chr17	73258657	73258657	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aggaatattatcgcaagccaGtggaggagctaactgaggag	14	6	0	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr17:73258657G>C	ENST00000579761.1	+	2	390	c.163G>C	c.(163-165)Gtg>Ctg	p.V55L	MRPS7_ENST00000245539.6_Missense_Mutation_p.V55L|MRPS7_ENST00000579002.1_Missense_Mutation_p.V84L			Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7	55					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)	6	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TCGCAAGCCAGTGGAGGAGCT	0.493													12	221					0	0	1	0	0	C	73258657	G	C	73258657	3	2	14	1	0	0	0	0	1	0	0	0	9896	1029	36	5	169	5	MRPS7	17	73258657	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	65680179	73258657	7936553	57	1003										
CARD14	79092	broad.mit.edu	37	chr17	78172300	78172301	+	Frame_Shift_Ins	INS	-	-	G													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	agcagatcagcgtcatcggcINSgggaacctcacgggcatctt							TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr17:78172300_78172301insG	ENST00000573882.1	+	15	2297_2298	c.1761_1762insG	c.(1759-1764)ggggaafs	p.E588fs	CARD14_ENST00000570421.1_Frame_Shift_Ins_p.E588fs|CARD14_ENST00000344227.2_Frame_Shift_Ins_p.E588fs|CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000392434.2_Frame_Shift_Ins_p.E351fs			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	588	PDZ.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCGTCATCGGCGGGAACCTCAC	0.678													7	361	---	---	---	---						G	78172301	-	G	78172300	7	5	14	1	0	1	1	0	0	0	0	0	2664	755	27	0	1807	0	CARD14	17	78172300	Frame_Shift_Ins	INS	-	TCGA-N5-A59F-01A-11D-A28R-08	4913643	78172300	3022910	58	1004										
ASXL3	80816	broad.mit.edu	37	chr18	31325498	31325498	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ttcacagccctgaggtcaaaCagcaaaagcggctgctcccc	9	15	2	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr18:31325498C>A	ENST00000269197.5	+	12	5686	c.5686C>A	c.(5686-5688)Cag>Aag	p.Q1896K		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1896					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TGAGGTCAAACAGCAAAAGCG	0.507													28	430					2.14196e-07	2.31161e-07	1	1	0	A	31325498	C	A	31325498	3	1	14	1	0	0	0	0	1	0	0	0	1067	479	17	5	5732	5	ASXL3	18	31325498	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		31325498	46751750	59	1005										
SYDE1	85360	broad.mit.edu	37	chr19	15224655	15224655	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	tcggcgagccgagggtcaccGgtgacttcgaagacgacttc	14	12	1	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr19:15224655G>A	ENST00000600252.1	+	5	2702	c.1060G>A	c.(1060-1062)Ggt>Agt	p.G354S	SYDE1_ENST00000600440.1_Missense_Mutation_p.G630S|SYDE1_ENST00000342784.2_Missense_Mutation_p.G697S			Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	697					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|pancreas(1)|skin(1)	17						GAGGGTCACCGGTGACTTCGA	0.622													6	311					0	0	1	0	0	A	15224655	G	A	15224655	3	1	14	1	0	0	0	0	1	0	0	0	15491	1116	39	1	2119	1	SYDE1	19	15224655	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08		15224655	43904328	60	1006										
CYP4F3	4051	broad.mit.edu	37	chr19	15756607	15756607	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	atatgtgctgctggtgggtgGggccctggcacgcaatcgtc	16	10	0	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr19:15756607G>T	ENST00000221307.7	+	3	325	c.277G>T	c.(277-279)Ggg>Tgg	p.G93W	CYP4F3_ENST00000586182.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000591058.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	93					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CTGGTGGGTGGGGCCCTGGCA	0.567													37	46					1.04352e-10	1.14892e-10	1	1	0	T	15756607	G	T	15756607	3	4	14	1	0	0	0	0	1	0	0	0	4213	1232	43	5	283	5	CYP4F3	19	15756607	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	531952	15756607	43372376	61	1007										
TSHZ3	57616	broad.mit.edu	37	chr19	31768484	31768484	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gtccagggcaggcagggaggGcttggcggccttgcccaggt	19	11	0	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr19:31768484G>T	ENST00000240587.4	-	2	2542	c.2215C>A	c.(2215-2217)Ccc>Acc	p.P739T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	739					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGCAGGGAGGGCTTGGCGGCC	0.617													43	90					6.45866e-13	7.33327e-13	1	1	0	T	31768484	G	T	31768484	3	4	14	1	0	0	0	0	1	0	0	0	16685	1203	42	5	1034	5	TSHZ3	19	31768484	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	16011877	31768484	27360499	62	1008										
CYP2A7	1549	broad.mit.edu	37	chr19	41386411	41386411	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gctccggatggcctcgatgaGgaagcccgactcctcctgga	13	14	0	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr19:41386411G>T	ENST00000301146.4	-	3	1007	c.466C>A	c.(466-468)Ctc>Atc	p.L156I	CTC-490E21.12_ENST00000601627.1_Intron|CYP2A7_ENST00000291764.3_Missense_Mutation_p.L105I	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	156						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GCCTCGATGAGGAAGCCCGAC	0.667													11	105					2.80697e-09	3.0596e-09	1	1	0	T	41386411	G	T	41386411	3	4	14	1	0	0	0	0	1	0	0	0	4186	1000	35	5	1046	5	CYP2A7	19	41386411	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	9617927	41386411	17742572	63	1009										
ZC3H4	23211	broad.mit.edu	37	chr19	47572491	47572491	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gggacaccggcgcctggcttCggccggcctgggggccctcc	17	17	0	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr19:47572491C>A	ENST00000253048.5	-	14	2293	c.2256G>T	c.(2254-2256)ccG>ccT	p.P752P	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	752							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CGCCTGGCTTCGGCCGGCCTG	0.677													5	51					0.184627	0.184627	1	1	0	A	47572491	C	A	47572491	2	1	14	1	0	0	0	0	0	0	0	1	17628	871	31	2		2	ZC3H4	19	47572491	Silent	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	6186080	47572491	11556492	64	1010										
ZNF446	55663	broad.mit.edu	37	chr19	58991357	58991357	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gctggggatgctgctcacggGgacaggcgtctgcagaagcc	17	11	2	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr19:58991357G>A	ENST00000596341.1	+	6	2993	c.773G>A	c.(772-774)gGg>gAg	p.G258E	ZNF446_ENST00000594369.1_Missense_Mutation_p.G258E|ZNF446_ENST00000335841.4_Missense_Mutation_p.G230R			Q9NWS9	ZN446_HUMAN	zinc finger protein 446	258					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CTGCTCACGGGGACAGGCGTC	0.657													11	5					0	0	1	0	0	A	58991357	G	A	58991357	3	1	14	1	0	0	0	0	1	0	0	0	17975	1232	43	3	791	3	ZNF446	19	58991357	Missense_Mutation	SNP	G	TCGA-N5-A59F-01A-11D-A28R-08	11418866	58991357	137626	65	1011										
CST5	1473	broad.mit.edu	37	chr20	23856835	23856835	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	gcacagacccctagactttcCggcacttgtagttcagaatg	9	12	1	3	rs146272783	byFrequency	TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr20:23856835C>T	ENST00000304710.4	-	3	492	c.419G>A	c.(418-420)cGg>cAg	p.R140Q		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	140						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						CTAGACTTTCCGGCACTTGTA	0.527													52	69					0	0	1	0	0	T	23856835	C	T	23856835	3	4	14	1	0	0	0	0	1	0	0	0	4000	652	23	1	13	1	CST5	20	23856835	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		23856835	39168685	66	1012										
DHX35	60625	broad.mit.edu	37	chr20	37634873	37634873	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	actgtggctttgtgaaactcCgagcctacaatcccaggaca	9	12	0	1			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr20:37634873C>A	ENST00000252011.3	+	12	1129	c.1096C>A	c.(1096-1098)Cga>Aga	p.R366R	DHX35_ENST00000373325.2_Silent_p.R366R|DHX35_ENST00000373323.4_Silent_p.R335R	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	366	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding	p.R366R(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				TGTGAAACTCCGAGCCTACAA	0.532													102	558					6.97839e-76	8.26788e-76	1	1	0	A	37634873	C	A	37634873	2	1	14	1	0	0	0	0	0	0	0	1	4536	644	23	5		5	DHX35	20	37634873	Silent	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08	13778038	37634873	25390647	67	1013										
BAGE2	85319	broad.mit.edu	37	chr21	11033264	11033265	+	RNA	INS	-	-	A													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aaaagttactaaaaattactINSaaaaaatctatataatgcct					rs143646950	by1000genomes	TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr21:11033264_11033265insA	ENST00000470054.1	-	0	1476									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAAAATTACTAAAAAATCTAT	0.257													2	4	---	---	---	---						A	11033265	-	A	11033264	6	5	14	0	1	1	1	0	0	0	0	0	1290	1537	53	0		0	BAGE2	21	11033264	RNA	INS	-	TCGA-N5-A59F-01A-11D-A28R-08		11033264	37096631	68	1014										
BAGE2	85319	broad.mit.edu	37	chr21	11059172	11059175	+	RNA	DEL	CTAT	CTAT	-													0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	aatctctctgtgggaaatgaCtatctaacataaatttttgt					rs56885467		TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr21:11059172_11059175delCTAT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGGAAATGACTATCTAACATAAA	0.373													3	4	---	---	---	---						-	11059175	CTAT	-	11059172	6	5	14	0	1	1	0	1	0	0	0	0	1290	580	20	0		0	BAGE2	21	11059172	RNA	DEL	CTAT	TCGA-N5-A59F-01A-11D-A28R-08	25908	11059172	37070723	69	1015										
MYH9	4627	broad.mit.edu	37	chr22	36696961	36696961	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	ggcagcgctcctcctcctccTccaccctggcctctaggtca	8	20	2	0			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chr22:36696961T>A	ENST00000216181.5	-	22	3004	c.2774A>T	c.(2773-2775)gAg>gTg	p.E925V		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	925					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CTCCTCCTCCTCCACCCTGGC	0.647			T	ALK	ALCL		"Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"		Hereditary Macrothrombocytopenia, MYH9-associated				4	126					0	0	1	0	0	A	36696961	T	A	36696961	3	1	14	1	0	0	0	0	1	0	0	0	10089	1551	54	4	3188	4	MYH9	22	36696961	Missense_Mutation	SNP	T	TCGA-N5-A59F-01A-11D-A28R-08		36696961	14607605	70	1016										
PABPC5	140886	broad.mit.edu	37	chrX	90690676	90690676	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0563380281690141	4	1	0.818713450292398	1.39863547758285	0.719298245614035	0.485714285714286	1	0	cagatgtcaccgaggacatgCtctataagaagttcaggcct	10	10	3	2			TCGA-N5-A59F-01A-11D-A28R-08	TCGA-N5-A59F-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dd5c58ec-271c-4f39-ab26-b6e9ae076a7e	10f926f4-b281-46f0-9d46-a1c231b10ca5	g.chrX:90690676C>T	ENST00000312600.3	+	2	314	c.100C>T	c.(100-102)Ctc>Ttc	p.L34F	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	34	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						CGAGGACATGCTCTATAAGAA	0.572													16	15					0	0	1	0	0	T	90690676	C	T	90690676	3	4	14	1	0	0	0	0	1	0	0	0	11413	797	28	3	102	3	PABPC5	23	90690676	Missense_Mutation	SNP	C	TCGA-N5-A59F-01A-11D-A28R-08		90690676	64579884	71	1017										
MTOR	2475	broad.mit.edu	37	chr1	11199368	11199368	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ttgggatacagaccttgcggGcactcttccacatgtttttc	9	11	1	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr1:11199368G>A	ENST00000361445.4	-	36	5199	c.5123C>T	c.(5122-5124)gCc>gTc	p.A1708V	MTOR_ENST00000495435.1_5'UTR	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1708	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GACCTTGCGGGCACTCTTCCA	0.507													4	116					0	0	1	0	0	A	11199368	G	A	11199368	3	1	15	1	0	0	0	0	1	0	0	0	10001	1203	42	3	2618	3	MTOR	1	11199368	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08		11199368	238051253	1	1018										
NCDN	23154	broad.mit.edu	37	chr1	36023792	36023792	+	Translation_Start_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gccctgtcgtgacttcatcaAtgtcgtgttgtgacctggct	11	11	2	2	rs141726468		TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr1:36023792A>G	ENST00000373243.2	+	1	384	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	NCDN_ENST00000356090.4_Start_Codon_SNP_p.M1V|NCDN_ENST00000459931.1_3'UTR|NCDN_ENST00000373253.3_Intron	NM_014284.2	NP_055099.1	Q9UBB6	NCDN_HUMAN	neurochondrin	1					neuron projection development	cytosol|dendrite|neuronal cell body				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|pancreas(1)|skin(2)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GACTTCATCAATGTCGTGTTG	0.587													98	5					0	0	1	0	0	G	36023792	A	G	36023792	1	3	15	1	0	0	0	0	0	0	0	0	10260	101	4	4		4	NCDN	1	36023792	Translation_Start_Site	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08	24824424	36023792	213226829	2	1019										
FAM102B	284611	broad.mit.edu	37	chr1	109171385	109171385	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	agatgacattgtagagaaaaTattacaaagtcaagacttca	7	5	2	4			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr1:109171385T>A	ENST00000370035.3	+	9	1269	c.929T>A	c.(928-930)aTa>aAa	p.I310K	FAM102B_ENST00000405454.1_Missense_Mutation_p.I310K	NM_001010883.2	NP_001010883.2	Q5T8I3	F102B_HUMAN	family with sequence similarity 102, member B	310										autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	5		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GTAGAGAAAATATTACAAAGT	0.408													21	39					0	0	1	0	0	A	109171385	T	A	109171385	3	1	15	1	0	0	0	0	1	0	0	0	5414	1406	49	4	963	4	FAM102B	1	109171385	Missense_Mutation	SNP	T	TCGA-N6-A4V9-01A-11D-A28R-08	73147593	109171385	140079236	3	1020										
OBSCN	84033	broad.mit.edu	37	chr1	228557666	228557666	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gacctgctcatccccatttgCcggcgagagtgaccgtgcca	11	15	1	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr1:228557666C>T	ENST00000570156.2	+	102	22936	c.22862C>T	c.(22861-22863)gCc>gTc	p.A7621V	OBSCN_ENST00000366707.4_Missense_Mutation_p.A4298V|OBSCN_ENST00000422127.1_Missense_Mutation_p.A6664V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6664	Fibronectin type-III 4.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCCCATTTGCCGGCGAGAGT	0.632													4	124					0	0	1	0	0	T	228557666	C	T	228557666	3	4	15	1	0	0	0	0	1	0	0	0	10859	739	26	3	21559	3	OBSCN	1	228557666	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	119386281	228557666	20692955	4	1021										
PLA2R1	0	broad.mit.edu	37	chr2	160918876	160918878	+	In_Frame_Del	DEL	CAG	CAG	-													0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gcgcagccccgcggcgccccCagcagcagcagcagcagcag							TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr2:160918876_160918878delCAG	ENST00000283243.7	-	1	243_245	c.37_39delCTG	c.(37-39)del	p.L13del	PLA2R1_ENST00000392771.1_In_Frame_Del_p.L13del	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	13					endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GCGGCGCCCCcagcagcagcagc	0.729													3	5	---	---	---	---						-	160918878	CAG	-	160918876	7	5	15	1	0	1	0	1	0	0	0	0	12057	581	21	0	4480	0	PLA2R1	2	160918876	In_Frame_Del	DEL	CAG	TCGA-N6-A4V9-01A-11D-A28R-08		160918876	82280497	5	1022										
SCN3A	6328	broad.mit.edu	37	chr2	165969452	165969452	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gtgaaatatgtttgaaatccAtaagcaacccatttgagaag	8	6	0	3			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr2:165969452A>T	ENST00000360093.3	-	21	4277	c.3786T>A	c.(3784-3786)taT>taA	p.Y1262*	SCN3A_ENST00000409101.3_Nonsense_Mutation_p.Y1213*|SCN3A_ENST00000283254.7_Nonsense_Mutation_p.Y1262*	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1262						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TTTGAAATCCATAAGCAACCC	0.318													114	112					0	0	1	0	0	T	165969452	A	T	165969452	4	4	15	1	0	0	0	0	0	1	0	0	13971	224	8	4	2248	4	SCN3A	2	165969452	Nonsense_Mutation	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08	5050576	165969452	77229921	6	1023										
CRYGC	1420	broad.mit.edu	37	chr2	208994374	208994374	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	agtggtggtttcgtagctgcGgccctggaaggccctgtcct	15	11	0	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr2:208994374G>C	ENST00000282141.3	-	2	80	c.43C>G	c.(43-45)Cgc>Ggc	p.R15G		NM_020989.3	NP_066269.1	P07315	CRGC_HUMAN	crystallin, gamma C	15	Beta/gamma crystallin 'Greek key' 1.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens			NS(1)|endometrium(1)|large_intestine(2)|lung(5)	9				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		TCGTAGCTGCGGCCCTGGAAG	0.522													6	306					0	0	1	0	0	C	208994374	G	C	208994374	3	2	15	1	0	0	0	0	1	0	0	0	3939	1116	39	5	489	5	CRYGC	2	208994374	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	43024922	208994374	34204999	7	1024										
PLCL2	23228	broad.mit.edu	37	chr3	17051510	17051510	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ttttccgtcatatatggagaGaattatgagtcactggattt	9	5	2	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr3:17051510G>T	ENST00000418129.2	+	2	759	c.294G>T	c.(292-294)gaG>gaT	p.E98D	PLCL2_ENST00000432376.1_Missense_Mutation_p.E98D|PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000396755.2_Missense_Mutation_p.E98D	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	224					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.E98D(1)		breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TATATGGAGAGAATTATGAGT	0.418													16	87					1.15088e-07	1.25945e-07	1	1	0	T	17051510	G	T	17051510	3	4	15	1	0	0	0	0	1	0	0	0	12087	933	33	2	672	2	PLCL2	3	17051510	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08		17051510	180970920	8	1025										
LARS2	23395	broad.mit.edu	37	chr3	45583357	45583357	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gaggaagctctgtgcccactAcacttgggatgccagtgtgc	13	11	1	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr3:45583357A>T	ENST00000415258.1	+	20	2582	c.2441A>T	c.(2440-2442)tAc>tTc	p.Y814F	LARS2_ENST00000414984.1_Missense_Mutation_p.Y771F|LARS2_ENST00000265537.3_Missense_Mutation_p.Y814F			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	814					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	TGTGCCCACTACACTTGGGAT	0.597													3	38					0	0	1	0	0	T	45583357	A	T	45583357	3	4	15	1	0	0	0	0	1	0	0	0	8673	391	14	4	2515	4	LARS2	3	45583357	Missense_Mutation	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08	28531847	45583357	152439073	9	1026										
CEP70	80321	broad.mit.edu	37	chr3	138290180	138290180	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	caatagcacatttatgctttCccattctgcttcttcctgct	4	13	2	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr3:138290180C>A	ENST00000264982.3	-	4	354	c.88G>T	c.(88-90)Gaa>Taa	p.E30*	CEP70_ENST00000542237.1_Nonsense_Mutation_p.E10*|CEP70_ENST00000489254.1_Intron|CEP70_ENST00000484888.1_Nonsense_Mutation_p.E30*|CEP70_ENST00000481834.1_Nonsense_Mutation_p.E30*|CEP70_ENST00000478673.1_5'UTR|CEP70_ENST00000464035.1_Nonsense_Mutation_p.E30*	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	30					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						TTTATGCTTTCCCATTCTGCT	0.328													3	27					0.115264	0.117286	1	1	0	A	138290180	C	A	138290180	4	1	15	1	0	0	0	0	0	1	0	0	3281	864	30	2	1765	2	CEP70	3	138290180	Nonsense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	92706823	138290180	59732250	10	1027										
AREG	374	broad.mit.edu	37	chr4	75312484	75312484	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	aaatacctggctatattgtcGatgattcagtcagaggtgag	11	6	2	3			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr4:75312484G>C	ENST00000395748.3	+	2	507	c.295G>C	c.(295-297)Gat>Cat	p.D99H	AREG_ENST00000502307.1_Missense_Mutation_p.D99H|AREG_ENST00000264487.2_Missense_Mutation_p.D99H	NM_001657.2	NP_001648.1	P15514	AREG_HUMAN	amphiregulin	99					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity			lung(4)	4			Lung(101;0.196)			CTATATTGTCGATGATTCAGT	0.448													33	108					0	0	1	0	0	C	75312484	G	C	75312484	3	2	15	1	0	0	0	0	1	0	0	0	840	1058	37	2	301	2	AREG	4	75312484	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08		75312484	115841792	11	1028										
DAB2	1601	broad.mit.edu	37	chr5	39377323	39377323	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ggagccattgaaggggactgAttgaagaccaaagatgctgt	14	6	0	5			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr5:39377323A>G	ENST00000320816.6	-	12	2033	c.1566T>C	c.(1564-1566)aaT>aaC	p.N522N	DAB2_ENST00000509337.1_Silent_p.N501N|DAB2_ENST00000545653.1_Silent_p.N501N|DAB2_ENST00000339788.6_Silent_p.N304N	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	522					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			AAGGGGACTGATTGAAGACCA	0.483													54	64					0	0	1	0	0	G	39377323	A	G	39377323	2	3	15	1	0	0	0	0	0	0	0	1	4242	330	12	4		4	DAB2	5	39377323	Silent	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08		39377323	141537937	12	1029										
PLCXD3	345557	broad.mit.edu	37	chr5	41382479	41382479	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	taacgaattccagctcctagCtggccagtaaaattcattgt	7	10	1	0	rs143006059		TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr5:41382479C>A	ENST00000377801.3	-	2	335	c.261G>T	c.(259-261)caG>caT	p.Q87H	PLCXD3_ENST00000328457.3_Missense_Mutation_p.Q87H			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	87	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						CAGCTCCTAGCTGGCCAGTAA	0.443													16	56					6.72482e-11	7.96e-11	1	1	0	A	41382479	C	A	41382479	3	1	15	1	0	0	0	0	1	0	0	0	12090	796	28	5	712	5	PLCXD3	5	41382479	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	2005156	41382479	139532781	13	1030										
RASGRF2	5924	broad.mit.edu	37	chr5	80390692	80390693	+	Frame_Shift_Del	DEL	GT	GT	-													0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	aagctaaaggttctgggcaaGtgtttgggcacctggatttt							TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr5:80390692_80390693delGT	ENST00000265080.4	+	12	1703_1704	c.1636_1637delGT	c.(1636-1638)gfs	p.V546fs		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	546	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TTCTGGGCAAGTGTTTGGGCAC	0.436													30	45	---	---	---	---						-	80390693	GT	-	80390692	7	5	15	1	0	1	0	1	0	0	0	0	13124	1029	36	0	1682	0	RASGRF2	5	80390692	Frame_Shift_Del	DEL	GT	TCGA-N6-A4V9-01A-11D-A28R-08	39008213	80390692	100524568	14	1031										
GABRA6	2559	broad.mit.edu	37	chr5	161128593	161128593	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gaggccaataaagtgctcacGagagcgcccatcttacaatc	9	12	2	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr5:161128593G>T	ENST00000523217.1	+	9	1388	c.1146G>T	c.(1144-1146)acG>acT	p.T382T	GABRA6_ENST00000274545.5_Silent_p.T392T	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	392					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAGTGCTCACGAGAGCGCCCA	0.463										TCGA Ovarian(5;0.080)			9	90					9.70103e-10	1.10325e-09	1	1	0	T	161128593	G	T	161128593	2	4	15	1	0	0	0	0	0	0	0	1	6199	1045	37	2		2	GABRA6	5	161128593	Silent	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	80737901	161128593	19786667	15	1032										
FBXO30	84085	broad.mit.edu	37	chr6	146127324	146127324	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gatgttcagcaactttatttCgggccatggtaaatggacat	10	7	1	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr6:146127324C>T	ENST00000237281.4	-	2	384	c.218G>A	c.(217-219)cGa>cAa	p.R73Q		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	73							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		AACTTTATTTCGGGCCATGGT	0.418													106	105					0	0	1	0	0	T	146127324	C	T	146127324	3	4	15	1	0	0	0	0	1	0	0	0	5772	884	31	1	2027	1	FBXO30	6	146127324	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08		146127324	24987743	16	1033										
TULP4	56995	broad.mit.edu	37	chr6	158923393	158923393	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gcagtggcaacgtggaggagGtgtgccggccccgcacccgg	18	13	0	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr6:158923393G>T	ENST00000367097.3	+	13	4055	c.2698G>T	c.(2698-2700)Gtg>Ttg	p.V900L	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	900					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CGTGGAGGAGGTGTGCCGGCC	0.642													13	129					2.32078e-09	2.58857e-09	1	1	0	T	158923393	G	T	158923393	3	4	15	1	0	0	0	0	1	0	0	0	16837	1261	44	5	2748	5	TULP4	6	158923393	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	12796069	158923393	12191674	17	1034										
ABCA13	154664	broad.mit.edu	37	chr7	48411971	48411971	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ctgagctacctcttgagtgcAtttttcagccaagctaatac	7	11	2	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr7:48411971A>G	ENST00000435803.1	+	33	11034	c.11010A>G	c.(11008-11010)gcA>gcG	p.A3670A		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3670					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCTTGAGTGCATTTTTCAGCC	0.423													89	96					0	0	1	0	0	G	48411971	A	G	48411971	2	3	15	1	0	0	0	0	0	0	0	1	31	204	8	4		4	ABCA13	7	48411971	Silent	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08		48411971	110726692	18	1035										
GRM3	0	broad.mit.edu	37	chr7	86468807	86468807	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gctatctgttactcagccctGctgaccaagacaaactgcat	7	13	2	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr7:86468807G>A	ENST00000361669.2	+	4	3076	c.1977G>A	c.(1975-1977)ctG>ctA	p.L659L	GRM3_ENST00000546348.1_Silent_p.L251L|GRM3_ENST00000536043.1_Silent_p.L531L|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000439827.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	659					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ACTCAGCCCTGCTGACCAAGA	0.527													99	88					0	0	1	0	0	A	86468807	G	A	86468807	2	1	15	1	0	0	0	0	0	0	0	1	6838	1306	46	3		3	GRM3	7	86468807	Silent	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	38056836	86468807	72669856	19	1036										
DLGAP2	9228	broad.mit.edu	37	chr8	1626408	1626408	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gttttaaacgttctaacagcGtcacggccgccgtccaagct	9	13	2	0	rs34274599		TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr8:1626408G>A	ENST00000421627.2	+	9	2211	c.2077G>A	c.(2077-2079)Gtc>Atc	p.V693I		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	772					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TTCTAACAGCGTCACGGCCGC	0.557													24	78					0	0	1	0	0	A	1626408	G	A	1626408	3	1	15	1	0	0	0	0	1	0	0	0	4588	1145	40	1	2107	1	DLGAP2	8	1626408	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08		1626408	144737614	20	1037										
ASH2L	9070	broad.mit.edu	37	chr8	37993284	37993284	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	tcactgtacaagagctgcacGgtacgtacatgtttccatcc	8	12	1	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr8:37993284G>A	ENST00000343823.6	+	14	2028	c.1719_splice	c.e14+1	p.T573_splice	ASH2L_ENST00000250635.7_Intron|ASH2L_ENST00000521652.1_Intron|ASH2L_ENST00000545394.1_Splice_Site_p.T434_splice|ASH2L_ENST00000428278.2_Splice_Site_p.T479_splice	NM_004674.4	NP_004665.2	Q9UBL3	ASH2L_HUMAN	ash2 (absent, small, or homeotic)-like (Drosophila)	573	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)	19	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				AGAGCTGCACGGTACGTACAT	0.423													12	27					0	0	1	0	0	A	37993284	G	A	37993284	5	1	15	1	0	0	0	0	0	0	1	0	1041	1130	39	1	1773	1	ASH2L	8	37993284	Splice_Site	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	36366876	37993284	108370738	21	1038										
ANK1	286	broad.mit.edu	37	chr8	41530024	41530024	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ctcttagaacctggcagcttCtcttctgacctctgaccttc	6	15	4	3			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr8:41530024C>A	ENST00000396942.1	-	38	5027	c.4944G>T	c.(4942-4944)gaG>gaT	p.E1648D	ANK1_ENST00000347528.4_Missense_Mutation_p.E1648D|ANK1_ENST00000265709.8_Missense_Mutation_p.E1689D|ANK1_ENST00000396945.1_Missense_Mutation_p.E1648D|ANK1_ENST00000289734.7_Missense_Mutation_p.E1648D|ANK1_ENST00000352337.4_Missense_Mutation_p.E1648D|ANK1_ENST00000379758.2_Missense_Mutation_p.E1648D			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1648	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTGGCAGCTTCTCTTCTGACC	0.537													9	304					0.00448238	0.00464247	1	1	0	A	41530024	C	A	41530024	3	1	15	1	0	0	0	0	1	0	0	0	616	912	32	2	1047	2	ANK1	8	41530024	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	3536740	41530024	104833998	22	1039										
POTEA	340441	broad.mit.edu	37	chr8	43147752	43147752	+	RNA	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	caggggaagcggcaagaacaAcatgggtgcttggagagacc	16	8	0	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr8:43147752A>T	ENST00000522175.2	+	0	127							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGCAAGAACAACATGGGTGCT	0.607													8	123					0	0	1	0	0	T	43147752	A	T	43147752	1	4	15	0	1	0	0	0	0	0	0	0	12308	43	2	4		4	POTEA	8	43147752	RNA	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08	1617728	43147752	103216270	23	1040										
SLC10A5	347051	broad.mit.edu	37	chr8	82606828	82606828	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ggagtagactgtctttttgtTtgagcactttgactttcaca	9	7	2	3			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr8:82606828T>C	ENST00000518568.1	-	1	1581	c.380A>G	c.(379-381)aAa>aGa	p.K127R		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	127						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						GTCTTTTTGTTTGAGCACTTT	0.353													27	40					0	0	1	0	0	C	82606828	T	C	82606828	3	2	15	1	0	0	0	0	1	0	0	0	14431	1841	64	4	938	4	SLC10A5	8	82606828	Missense_Mutation	SNP	T	TCGA-N6-A4V9-01A-11D-A28R-08	39459076	82606828	63757194	24	1041										
LYZL2	119180	broad.mit.edu	37	chr10	30901770	30901770	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ccaatagttcattccttgtgTctctttaacaattttcttgg	5	9	3	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr10:30901770T>C	ENST00000375318.2	-	4	552	c.496A>G	c.(496-498)Aca>Gca	p.T166A		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	120					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				ATTCCTTGTGTCTCTTTAACA	0.418													5	33					0	0	1	0	0	C	30901770	T	C	30901770	3	2	15	1	0	0	0	0	1	0	0	0	9177	1667	58	4	96	4	LYZL2	10	30901770	Missense_Mutation	SNP	T	TCGA-N6-A4V9-01A-11D-A28R-08		30901770	104632977	25	1042										
SLIT1	6585	broad.mit.edu	37	chr10	98761065	98761065	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	agatggcatagcccctctggAcctggtgaaagtcccggaca	12	12	1	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr10:98761065A>G	ENST00000266058.4	-	37	4654	c.4409T>C	c.(4408-4410)gTc>gCc	p.V1470A	SLIT1_ENST00000371070.4_Missense_Mutation_p.S1429P|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1470	CTCK.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCCCCTCTGGACCTGGTGAAA	0.677													50	20					0	0	1	0	0	G	98761065	A	G	98761065	3	3	15	1	0	0	0	0	1	0	0	0	14792	275	10	4	199	4	SLIT1	10	98761065	Missense_Mutation	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08	67859295	98761065	36773682	26	1043										
SOX6	55553	broad.mit.edu	37	chr11	16340073	16340073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ggcaagactccctttgcggcGctctggggttccaaaagtaa	12	11	1	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr11:16340073G>A	ENST00000352083.6	-	3	441	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C	SOX6_ENST00000396356.3_Missense_Mutation_p.R122C|SOX6_ENST00000316399.6_Missense_Mutation_p.R122C|SOX6_ENST00000527619.1_Missense_Mutation_p.R125C|SOX6_ENST00000533658.1_5'UTR|SOX6_ENST00000528429.1_Missense_Mutation_p.R122C|SOX6_ENST00000528252.1_Missense_Mutation_p.R122C			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	122					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity	p.R122C(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						CCTTTGCGGCGCTCTGGGGTT	0.502													88	6					0	0	1	0	0	A	16340073	G	A	16340073	3	1	15	1	0	0	0	0	1	0	0	0	15008	1087	38	1	2220	1	SOX6	11	16340073	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08		16340073	118666443	27	1044										
NPAS4	266743	broad.mit.edu	37	chr11	66191699	66191699	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ctccatgagcccttccagacCcatttgcccaccccatccag	5	20	0	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr11:66191699C>G	ENST00000311034.2	+	7	1514	c.1338C>G	c.(1336-1338)acC>acG	p.T446T		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	446					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CCTTCCAGACCCATTTGCCCA	0.557													17	179					0	0	1	0	0	G	66191699	C	G	66191699	2	3	15	1	0	0	0	0	0	0	0	1	10611	610	22	5		5	NPAS4	11	66191699	Silent	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	49851626	66191699	68814817	28	1045										
MRPL11	65003	broad.mit.edu	37	chr11	66204693	66204693	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	agctttgatgcgggcaatctCatacacatgcttcaaggtca	9	10	3	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr11:66204693C>T	ENST00000310999.7	-	4	448	c.355G>A	c.(355-357)Gag>Aag	p.E119K	MRPL11_ENST00000430466.2_Missense_Mutation_p.E93K|MRPL11_ENST00000329819.4_Missense_Mutation_p.E119K|MRPL11_ENST00000524576.1_5'UTR	NM_016050.3	NP_057134.1	Q9Y3B7	RM11_HUMAN	mitochondrial ribosomal protein L11	119					translation		structural constituent of ribosome			endometrium(3)|lung(2)|ovary(1)|prostate(1)	7						CGGGCAATCTCATACACATGC	0.567													37	0					0	0	1	0	0	T	66204693	C	T	66204693	3	4	15	1	0	0	0	0	1	0	0	0	9824	835	29	3	308	3	MRPL11	11	66204693	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	12994	66204693	68801823	29	1046										
SCN2B	6327	broad.mit.edu	37	chr11	118038953	118038953	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ggggttccctgagaactccaCgcggtcttgaaaccgctcca	11	14	1	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr11:118038953C>T	ENST00000278947.5	-	3	536	c.295G>A	c.(295-297)Gtg>Atg	p.V99M		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	99	Ig-like C2-type.				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		GAGAACTCCACGCGGTCTTGA	0.542													34	4					0	0	1	0	0	T	118038953	C	T	118038953	3	4	15	1	0	0	0	0	1	0	0	0	13970	536	19	1	360	1	SCN2B	11	118038953	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	51834260	118038953	16967563	30	1047										
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			14	8					0	0	1	0	0	T	25398284	C	T	25398284	3	4	15	1	0	0	0	0	1	0	0	0	8480	507	18	3	671	3	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08		25398284	108453611	31	1048										
TMEM5	10329	broad.mit.edu	37	chr12	64173847	64173847	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	cgggcgccgccgccaggcgcCggccgggtccccgcggggcc	19	20	0	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr12:64173847C>G	ENST00000261234.6	+	1	265	c.107C>G	c.(106-108)cCg>cGg	p.P36R	RP11-415I12.3_ENST00000509615.2_RNA	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	36						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		cgccaggcgccggccgggtcc	0.716													8	12					0	0	1	0	0	G	64173847	C	G	64173847	3	3	15	1	0	0	0	0	1	0	0	0	16233	652	23	5	109	5	TMEM5	12	64173847	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	38775563	64173847	69678048	32	1049										
LGR5	8549	broad.mit.edu	37	chr12	71918250	71918250	+	Frame_Shift_Del	DEL	A	A	-													0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	tcactggcctttacagtcttAaagttctgtaagtaaactga							TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr12:71918250delA	ENST00000266674.5	+	3	660	c.349delA	c.(349-351)aafs	p.K117fs	LGR5_ENST00000536515.1_Frame_Shift_Del_p.K117fs|LGR5_ENST00000540815.2_Frame_Shift_Del_p.K117fs			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	117						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TTACAGTCTTAAAGTTCTGTA	0.408													9	67	---	---	---	---						-	71918250	A	-	71918250	7	5	15	1	0	1	0	1	0	0	0	0	8796	363	13	0	359	0	LGR5	12	71918250	Frame_Shift_Del	DEL	A	TCGA-N6-A4V9-01A-11D-A28R-08	7744403	71918250	61933645	33	1050										
TRPV4	59341	broad.mit.edu	37	chr12	110246256	110246256	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gctgaggggcaggggctttgGggctctgcggctgcttcctg	19	10	1	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr12:110246256G>A	ENST00000418703.2	-	2	498	c.404C>T	c.(403-405)cCc>cTc	p.P135L	TRPV4_ENST00000541794.1_Missense_Mutation_p.P135L|TRPV4_ENST00000536838.1_Missense_Mutation_p.P101L|TRPV4_ENST00000392719.2_Missense_Mutation_p.P135L|TRPV4_ENST00000346520.2_Missense_Mutation_p.P135L|TRPV4_ENST00000261740.2_Missense_Mutation_p.P135L|TRPV4_ENST00000537083.1_Missense_Mutation_p.P135L|TRPV4_ENST00000544971.1_Missense_Mutation_p.P135L	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	135					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						AGGGGCTTTGGGGCTCTGCGG	0.647													23	14					0	0	1	0	0	A	110246256	G	A	110246256	3	1	15	1	0	0	0	0	1	0	0	0	16658	1232	43	3	2267	3	TRPV4	12	110246256	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	38328006	110246256	23605639	34	1051										
FAM92B	339145	broad.mit.edu	37	chr16	85143873	85143873	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	cactttggccaggtcctcagCgaagcccctcatggtggccc	11	16	2	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr16:85143873C>G	ENST00000539556.1	-	2	369	c.214G>C	c.(214-216)Gct>Cct	p.A72P		NM_198491.1	NP_940893.1	Q6ZTR7	FA92B_HUMAN	family with sequence similarity 92, member B	72										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	16						AGGTCCTCAGCGAAGCCCCTC	0.667													21	17					0	0	1	0	0	G	85143873	C	G	85143873	3	3	15	1	0	0	0	0	1	0	0	0	5685	768	27	5	728	5	FAM92B	16	85143873	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08		85143873	5210880	35	1052										
CYB5D2	124936	broad.mit.edu	37	chr17	4058097	4058097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	agagaagcagacattcccgcCgtgcaacgcggagtggagct	14	11	0	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:4058097C>T	ENST00000301391.3	+	3	1021	c.521C>T	c.(520-522)cCg>cTg	p.P174L	CYB5D2_ENST00000575251.1_Missense_Mutation_p.P62L|CYB5D2_ENST00000575411.2_3'UTR|CYB5D2_ENST00000573984.1_Missense_Mutation_p.P62L	NM_144611.3	NP_653212.1	Q8WUJ1	NEUFC_HUMAN	cytochrome b5 domain containing 2	174					nervous system development	extracellular region	heme binding			breast(1)|large_intestine(3)|liver(2)|ovary(1)	7						ACATTCCCGCCGTGCAACGCG	0.612													34	2					0	0	1	0	0	T	4058097	C	T	4058097	3	4	15	1	0	0	0	0	1	0	0	0	4148	652	23	1	531	1	CYB5D2	17	4058097	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08		4058097	77137113	36	1053										
TP53	7157	broad.mit.edu	37	chr17	7578443	7578443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	catgtgctgtgactgcttgtAgatggccatggcgcggacgc	15	10	0	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:7578443A>G	ENST00000420246.2	-	5	619	c.487T>C	c.(487-489)Tac>Cac	p.Y163H	TP53_ENST00000445888.2_Missense_Mutation_p.Y163H|TP53_ENST00000269305.4_Missense_Mutation_p.Y163H|TP53_ENST00000455263.2_Missense_Mutation_p.Y163H|TP53_ENST00000359597.4_Missense_Mutation_p.Y163H|TP53_ENST00000413465.2_Missense_Mutation_p.Y163H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	163	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y163N(20)|p.Y163H(17)|p.0?(8)|p.Y163D(5)|p.I162_Y163>N(3)|p.Y163fs*7(2)|p.V157_C176del20(1)|p.Y163fs*1(1)|p.Y163_Q165delYKQ(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.I30_Y31>N(1)|p.I162_Y163delIY(1)|p.I69_Y70>N(1)|p.Y70N(1)|p.A161fs*7(1)|p.Y31N(1)|p.Y163fs*14(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Y163fs*18(1)|p.Y70D(1)|p.Y31D(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTGCTTGTAGATGGCCATG	0.622		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			43	2					0	0	1	0	0	G	7578443	A	G	7578443	3	3	15	1	0	0	0	0	1	0	0	0	16441	420	15	4	811	4	TP53	17	7578443	Missense_Mutation	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08	3520346	7578443	73616767	37	1054										
STAT3	6774	broad.mit.edu	37	chr17	40489876	40489876	+	Splice_Site	DEL	C	C	-													0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	tccattcagatcttgcatgtCtgcgaaggaagaaaaaactc							TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:40489876delC	ENST00000264657.5	-	7	863		c.e7-1		STAT3_ENST00000588969.1_Splice_Site|STAT3_ENST00000585517.1_Splice_Site|STAT3_ENST00000389272.3_Splice_Site|STAT3_ENST00000404395.3_Splice_Site	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)						cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TCTTGCATGTCTGCGAAGGAA	0.507									Hyperimmunoglobulin E Recurrent Infection Syndrome				24	0	---	---	---	---						-	40489876	C	-	40489876	8	5	15	1	0	1	0	1	0	0	1	0	15321	927	32	0	1834	0	STAT3	17	40489876	Splice_Site	DEL	C	TCGA-N6-A4V9-01A-11D-A28R-08	32911433	40489876	40705334	38	1055										
CNTNAP1	8506	broad.mit.edu	37	chr17	40839788	40839788	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	gtaccgcaccctatcaacttCggaggccctcacaacttcgt	7	16	2	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:40839788C>T	ENST00000264638.4	+	8	1312	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	365					axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CTATCAACTTCGGAGGCCCTC	0.617													66	5					0	0	1	0	0	T	40839788	C	T	40839788	2	4	15	1	0	0	0	0	0	0	0	1	3669	883	31	1		1	CNTNAP1	17	40839788	Silent	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	349912	40839788	40355422	39	1056										
NME1	4830	broad.mit.edu	37	chr17	49237345	49237345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ctgtcctgttgaataggcttCcgaagatcttctcaaggaac	9	10	2	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:49237345C>T	ENST00000511355.1	+	3	217	c.131C>T	c.(130-132)tCc>tTc	p.S44F	NME1_ENST00000013034.3_Missense_Mutation_p.S69F|NME2_ENST00000376392.6_Missense_Mutation_p.S44F|NME2_ENST00000555572.1_Missense_Mutation_p.S69F|NME1_ENST00000480143.1_Missense_Mutation_p.S69F|NME2_ENST00000393193.2_Missense_Mutation_p.S44F|NME1_ENST00000393196.3_Missense_Mutation_p.S44F|NME1_ENST00000336097.3_Missense_Mutation_p.S69F					NME/NM23 nucleoside diphosphate kinase 1											endometrium(1)|large_intestine(1)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			GAATAGGCTTCCGAAGATCTT	0.463													59	152					0	0	1	0	0	T	49237345	C	T	49237345	3	4	15	1	0	0	0	0	1	0	0	0	10535	855	30	3	216	3	NME1	17	49237345	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	8397557	49237345	31957865	40	1057										
CLTC	1213	broad.mit.edu	37	chr17	57721745	57721745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	taggagagcaggcccaggtgGtaatcattgatatgaatgac	13	6	1	4			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:57721745G>A	ENST00000269122.3	+	2	425	c.151G>A	c.(151-153)Gta>Ata	p.V51I	CLTC_ENST00000393043.1_Missense_Mutation_p.V51I|CLTC_ENST00000579456.1_Missense_Mutation_p.V51I	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	51	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GGCCCAGGTGGTAATCATTGA	0.443			T	"ALK, TFE3"	"ALCL, renal "								16	94					0	0	1	0	0	A	57721745	G	A	57721745	3	1	15	1	0	0	0	0	1	0	0	0	3589	1261	44	3	157	3	CLTC	17	57721745	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	8484400	57721745	23473465	41	1058										
CD300A	11314	broad.mit.edu	37	chr17	72473654	72473654	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	tgctagcctggaggatgtttCagaaatggatcaaaggtgag	14	5	2	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:72473654C>T	ENST00000360141.3	+	4	901	c.613C>T	c.(613-615)Cag>Tag	p.Q205*	CD300A_ENST00000361933.3_Intron|CD300A_ENST00000577511.1_Nonsense_Mutation_p.Q75*|CD300A_ENST00000392625.3_Nonsense_Mutation_p.Q92*|CD300A_ENST00000310828.5_Nonsense_Mutation_p.Q92*	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	205					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						GAGGATGTTTCAGAAATGGAT	0.597													21	55					0	0	1	0	0	T	72473654	C	T	72473654	4	4	15	1	0	0	0	0	0	1	0	0	3018	827	29	3	627	3	CD300A	17	72473654	Nonsense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	14751909	72473654	8721556	42	1059										
FASN	2194	broad.mit.edu	37	chr17	80040213	80040213	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	acccacctgtccaggttcagGgtgccgctgtacttgggctt	12	13	1	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr17:80040213G>T	ENST00000306749.2	-	35	6215	c.5997C>A	c.(5995-5997)acC>acA	p.T1999T	FASN_ENST00000579758.1_5'UTR	NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1999	Beta-ketoacyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CCAGGTTCAGGGTGCCGCTGT	0.632													18	57					3.52763e-06	3.78894e-06	1	1	0	T	80040213	G	T	80040213	2	4	15	1	0	0	0	0	0	0	0	1	5715	1219	43	5		5	FASN	17	80040213	Silent	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08	7566559	80040213	1154997	43	1060										
UBA2	10054	broad.mit.edu	37	chr19	34936017	34936017	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ggatatgatccagttaaactTtttaccaaggttagatttac	7	6	0	2			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr19:34936017T>C	ENST00000439527.2	+	8	972	c.474T>C	c.(472-474)ctT>ctC	p.L158L	UBA2_ENST00000246548.4_Silent_p.L254L			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	254					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CAGTTAAACTTTTTACCAAGG	0.328													35	33					0	0	1	0	0	C	34936017	T	C	34936017	2	2	15	1	0	0	0	0	0	0	0	1	16888	1828	64	4		4	UBA2	19	34936017	Silent	SNP	T	TCGA-N6-A4V9-01A-11D-A28R-08		34936017	24192966	44	1061										
C19orf55	148137	broad.mit.edu	37	chr19	36259088	36259088	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	agcgagttccaggacgatccCgtgctgcaggtgctaagagc	14	11	0	1			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr19:36259088C>G	ENST00000544099.1	+	10	1315	c.1252C>G	c.(1252-1254)Cgt>Ggt	p.R418G	C19orf55_ENST00000396908.4_Silent_p.P416P			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	0										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGACGATCCCGTGCTGCAGG	0.632													4	35					0	0	1	0	0	G	36259088	C	G	36259088	3	3	15	1	0	0	0	0	1	0	0	0	1949	652	23	5	1290	5	C19orf55	19	36259088	Missense_Mutation	SNP	C	TCGA-N6-A4V9-01A-11D-A28R-08	1323071	36259088	22869895	45	1062										
KCNB1	3745	broad.mit.edu	37	chr20	47990733	47990733	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	ccatcatctcaatgctccggGcaaaagcatccttcatgttc	6	14	3	0			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chr20:47990733G>A	ENST00000371741.4	-	2	1530	c.1364C>T	c.(1363-1365)gCc>gTc	p.A455V		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	455					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AATGCTCCGGGCAAAAGCATC	0.458													4	131					0	0	1	0	0	A	47990733	G	A	47990733	3	1	15	1	0	0	0	0	1	0	0	0	8055	1203	42	3	1216	3	KCNB1	20	47990733	Missense_Mutation	SNP	G	TCGA-N6-A4V9-01A-11D-A28R-08		47990733	15034787	46	1063										
TNMD	64102	broad.mit.edu	37	chrX	99852508	99852508	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0425531914893617	2	1	0.655407833273446	0	0.886728245017015	0.428571428571429	1	0	tttcttctttcagaatgaagAaattaccacaactttctttg	4	8	4	3			TCGA-N6-A4V9-01A-11D-A28R-08	TCGA-N6-A4V9-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b58d961d-5aed-46f1-8661-c451574c842d	edefaab7-d004-4ab1-9049-42511bbefe5f	g.chrX:99852508A>G	ENST00000373031.4	+	5	648	c.431A>G	c.(430-432)gAa>gGa	p.E144G	TNMD_ENST00000485971.1_3'UTR	NM_022144.2	NP_071427.2	Q9H2S6	TNMD_HUMAN	tenomodulin	144	BRICHOS.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(7)|skin(1)	16						CAGAATGAAGAAATTACCACA	0.358													20	19					0	0	1	0	0	G	99852508	A	G	99852508	3	3	15	1	0	0	0	0	1	0	0	0	16381	246	9	4	449	4	TNMD	23	99852508	Missense_Mutation	SNP	A	TCGA-N6-A4V9-01A-11D-A28R-08		99852508	55418052	47	1064										
EPS15	2060	broad.mit.edu	37	chr1	51826976	51826976	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgggaaaggctgaaatggaTcattcagtttaaagggatca	12	5	3	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:51826976T>C	ENST00000371733.3	-	24	2507	c.2411A>G	c.(2410-2412)gAt>gGt	p.D804G	EPS15_ENST00000396122.4_Missense_Mutation_p.D481G|EPS15_ENST00000371730.2_Missense_Mutation_p.D670G	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	804	15 X 3 AA repeats of D-P-F.|Pro-rich.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(2)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						CTGAAATGGATCATTCAGTTT	0.368			T	MLL	ALL								10	83					0	0	1	0	0	C	51826976	T	C	51826976	3	2	16	1	0	0	0	0	1	0	0	0	5220	1435	50	4	287	4	EPS15	1	51826976	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08		51826976	197423645	1	1065										
LPHN2	23266	broad.mit.edu	37	chr1	82416095	82416095	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0	0	1	0	0	0	1	1	0	attctgtgaagcattagactCcaaggggataaagtggcctc	11	8	1	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:82416095C>G	ENST00000370728.1	+	9	2066	c.1421C>G	c.(1420-1422)tCc>tGc	p.S474C	LPHN2_ENST00000370723.1_Missense_Mutation_p.S474C|LPHN2_ENST00000394879.1_Missense_Mutation_p.S474C|LPHN2_ENST00000370725.1_Missense_Mutation_p.S474C|LPHN2_ENST00000370717.2_Missense_Mutation_p.S474C|LPHN2_ENST00000370727.1_Missense_Mutation_p.S474C|LPHN2_ENST00000370730.1_Missense_Mutation_p.S474C|LPHN2_ENST00000335786.5_Missense_Mutation_p.S474C|LPHN2_ENST00000271029.4_Missense_Mutation_p.S474C|LPHN2_ENST00000359929.3_Missense_Mutation_p.S474C|LPHN2_ENST00000370715.1_Missense_Mutation_p.S474C|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000319517.6_Missense_Mutation_p.S474C|LPHN2_ENST00000370721.1_Missense_Mutation_p.S412C|LPHN2_ENST00000370713.1_Missense_Mutation_p.S474C			O95490	LPHN2_HUMAN	latrophilin 2	474					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GCATTAGACTCCAAGGGGATA	0.428													35	26					0	0	1	0	0	G	82416095	C	G	82416095	3	3	16	1	0	0	0	0	1	0	0	0	8960	855	30	2	1439	2	LPHN2	1	82416095	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	30589119	82416095	166834526	2	1066										
PKN2	5586	broad.mit.edu	37	chr1	89279373	89279373	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	atgctgccggtggggacctaAtgatgcacattcatactgat	11	9	1	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:89279373A>G	ENST00000370521.3	+	16	2595	c.2236A>G	c.(2236-2238)Atg>Gtg	p.M746V	PKN2_ENST00000544045.1_Missense_Mutation_p.M420V|PKN2_ENST00000370505.3_Missense_Mutation_p.M589V|PKN2_ENST00000370513.5_Missense_Mutation_p.M698V	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	746	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TGGGGACCTAATGATGCACAT	0.403													39	103					0	0	1	0	0	G	89279373	A	G	89279373	3	3	16	1	0	0	0	0	1	0	0	0	12027	101	4	4	2298	4	PKN2	1	89279373	Missense_Mutation	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08	6863278	89279373	159971248	3	1067										
PAQR6	79957	broad.mit.edu	37	chr1	156213861	156213861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	attaggcccaaatctgggctCctcgtcagcactggggcctg	12	13	2	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:156213861C>T	ENST00000335852.1	-	7	1462	c.847G>A	c.(847-849)Gag>Aag	p.E283K	PAQR6_ENST00000540423.1_3'UTR|PAQR6_ENST00000360733.2_Missense_Mutation_p.E283K|PAQR6_ENST00000492619.1_5'UTR|PAQR6_ENST00000368270.1_3'UTR|PAQR6_ENST00000356983.2_Missense_Mutation_p.E283K|PAQR6_ENST00000292291.5_3'UTR	NM_024897.2	NP_079173.2	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	290						integral to membrane	receptor activity			lung(4)|ovary(1)	5	Hepatocellular(266;0.158)					AATCTGGGCTCCTCGTCAGCA	0.652													88	130					0	0	1	0	0	T	156213861	C	T	156213861	3	4	16	1	0	0	0	0	1	0	0	0	11485	864	30	3	212	3	PAQR6	1	156213861	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	66934488	156213861	93036760	4	1068										
FAM129A	116496	broad.mit.edu	37	chr1	184765126	184765126	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cagggctggcctggtttgacCctgtggggggctttagatct	16	9	1	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:184765126C>G	ENST00000367511.3	-	14	1965	c.1772G>C	c.(1771-1773)gGg>gCg	p.G591A	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	591					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						CTGGTTTGACCCTGTGGGGGG	0.498													72	78					0	0	1	0	0	G	184765126	C	G	184765126	3	3	16	1	0	0	0	0	1	0	0	0	5467	623	22	5	1018	5	FAM129A	1	184765126	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	28551265	184765126	64485495	5	1069										
ACTN2	88	broad.mit.edu	37	chr1	236906280	236906280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	atgagattcggagactggagCgcttggaacacctggctgag	15	8	0	3	rs148189507		TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:236906280C>T	ENST00000366578.4	+	11	1358	c.1192C>T	c.(1192-1194)Cgc>Tgc	p.R398C	ACTN2_ENST00000546208.1_5'UTR|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000542672.1_Missense_Mutation_p.R398C	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	398					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGACTGGAGCGCTTGGAACA	0.522													31	57					0	0	1	0	0	T	236906280	C	T	236906280	3	4	16	1	0	0	0	0	1	0	0	0	205	768	27	1	1234	1	ACTN2	1	236906280	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	52141154	236906280	12344341	6	1070										
OR2T3	343173	broad.mit.edu	37	chr1	248637452	248637452	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	ttctacacctacatgctcccGagttcctaccacacagctga	5	16	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr1:248637452G>A	ENST00000359594.2	+	1	826	c.801G>A	c.(799-801)ccG>ccA	p.P267P		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACATGCTCCCGAGTTCCTACC	0.547													50	318					0	0	1	0	0	A	248637452	G	A	248637452	2	1	16	1	0	0	0	0	0	0	0	1	11070	1045	37	1		1	OR2T3	1	248637452	Silent	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	11731172	248637452	613169	7	1071										
MSH6	2956	broad.mit.edu	37	chr2	48018140	48018140	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtggccttgtctggtttacaAccacccctttgatggaacat	9	11	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr2:48018140A>G	ENST00000234420.4	+	2	487	c.335A>G	c.(334-336)aAc>aGc	p.N112S	MSH6_ENST00000540021.1_Intron|MSH6_ENST00000538136.1_5'UTR|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	112	PWWP.				determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTGGTTTACAACCACCCCTTT	0.473			"Mis, N, F, S"		colorectal	"colorectal, endometrial, ovarian"		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				60	90					0	0	1	0	0	G	48018140	A	G	48018140	3	3	16	1	0	0	0	0	1	0	0	0	9922	43	2	4	341	4	MSH6	2	48018140	Missense_Mutation	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08		48018140	195181233	8	1072										
CEP68	23177	broad.mit.edu	37	chr2	65299631	65299631	+	Frame_Shift_Del	DEL	G	G	-													0	0	1	0	0	0	1	1	0	cggcgccctacctgcacagaGtctaggtggaaatcagaaga							TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr2:65299631delG	ENST00000377990.2	+	3	1604	c.1401delG	c.(1399-1401)gafs	p.E467fs	RAB1A_ENST00000494188.1_Intron|CEP68_ENST00000260569.4_Frame_Shift_Del_p.E467fs|CEP68_ENST00000546106.1_Frame_Shift_Del_p.E467fs|CEP68_ENST00000537589.1_Frame_Shift_Del_p.E79fs|CEP68_ENST00000497039.1_3'UTR	NM_015147.2	NP_055962.2	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	467					centrosome organization	centrosome				breast(1)|endometrium(6)|kidney(8)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32						CCTGCACAGAGTCTAGGTGGA	0.592													26	108	---	---	---	---						-	65299631	G	-	65299631	7	5	16	1	0	1	0	1	0	0	0	0	3280	1020	36	0	1407	0	CEP68	2	65299631	Frame_Shift_Del	DEL	G	TCGA-N6-A4VC-01A-11D-A28R-08	17281491	65299631	177899742	9	1073										
TTN	7273	broad.mit.edu	37	chr2	179449409	179449409	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aacataccaaatgggaactgCgcaaccatctttggagatgt	9	9	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr2:179449409C>A	ENST00000589042.1	-	310	65183	c.64959G>T	c.(64957-64959)gcG>gcT	p.A21653A	TTN_ENST00000460472.2_Silent_p.A12588A|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Silent_p.A19085A|TTN_ENST00000342175.6_Silent_p.A12780A|TTN_ENST00000359218.5_Silent_p.A12713A|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.A20012A|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20012	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.A19083A(1)|p.A12588A(1)|p.A19085A(1)|p.A12780A(1)|p.A12713A(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGGAACTGCGCAACCATCT	0.433													67	230					1.85257e-25	2.04613e-25	1	1	0	A	179449409	C	A	179449409	2	1	16	1	0	0	0	0	0	0	0	1	16796	755	27	5		5	TTN	2	179449409	Silent	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	114149778	179449409	63749964	10	1074										
ZNF662	389114	broad.mit.edu	37	chr3	42956577	42956577	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cttacgaatgtaaggactgtGggaagggcttcatgtggaac	14	6	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr3:42956577G>A	ENST00000541208.1	+	5	1381	c.1012G>A	c.(1012-1014)Ggg>Agg	p.G338R	ZNF662_ENST00000328199.6_Missense_Mutation_p.G364R|ZNF662_ENST00000440367.2_Missense_Mutation_p.G338R|KRBOX1_ENST00000426937.1_Intron|ZNF662_ENST00000422021.1_Intron			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TAAGGACTGTGGGAAGGGCTT	0.488													37	11					0	0	1	0	0	A	42956577	G	A	42956577	3	1	16	1	0	0	0	0	1	0	0	0	18127	1348	47	3	1213	3	ZNF662	3	42956577	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		42956577	155065853	11	1075										
IGSF10	285313	broad.mit.edu	37	chr3	151166217	151166217	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctcactgacataaggggctcTcactttacttccatcagcta	6	13	3	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr3:151166217T>C	ENST00000282466.3	-	4	1551	c.1552A>G	c.(1552-1554)Aga>Gga	p.R518G		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	518	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TAAGGGGCTCTCACTTTACTT	0.498													52	247					0	0	1	0	0	C	151166217	T	C	151166217	3	2	16	1	0	0	0	0	1	0	0	0	7640	1559	54	4	6379	4	IGSF10	3	151166217	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	108209640	151166217	46856213	12	1076										
ZAR1	326340	broad.mit.edu	37	chr4	48492843	48492843	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccatgcgcttcccgcgcaccGtcgccgtgtactcgcccctg	10	20	0	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr4:48492843G>A	ENST00000327939.4	+	1	575	c.535G>A	c.(535-537)Gtc>Atc	p.V179I		NM_175619.1	NP_783318.1	Q86SH2	ZAR1_HUMAN	zygote arrest 1	179					multicellular organismal development	cytoplasm|membrane	bile acid:sodium symporter activity			endometrium(1)|large_intestine(4)	5						CCCGCGCACCGTCGCCGTGTA	0.761													9	1					0	0	1	0	0	A	48492843	G	A	48492843	3	1	16	1	0	0	0	0	1	0	0	0	17574	1145	40	1	537	1	ZAR1	4	48492843	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		48492843	142661433	13	1077										
CEP135	9662	broad.mit.edu	37	chr4	56847395	56847395	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	atcttttcattctttaaggcTcaggaagaattatctgccct	6	9	5	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr4:56847395T>C	ENST00000257287.4	+	13	1753	c.1629T>C	c.(1627-1629)gcT>gcC	p.A543A		NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	543					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					TCTTTAAGGCTCAGGAAGAAT	0.318													23	30					0	0	1	0	0	C	56847395	T	C	56847395	2	2	16	1	0	0	0	0	0	0	0	1	3269	1538	54	4		4	CEP135	4	56847395	Silent	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	8354552	56847395	134306881	14	1078										
FBXW7	0	broad.mit.edu	37	chr4	153247303	153247303	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cacagcggactgctgcaacaTgacccatcaaaacatgtaaa	7	12	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr4:153247303T>C	ENST00000281708.4	-	10	2728	c.1499A>G	c.(1498-1500)cAt>cGt	p.H500R	FBXW7_ENST00000393956.3_Missense_Mutation_p.H324R|FBXW7_ENST00000263981.5_Missense_Mutation_p.H420R|FBXW7_ENST00000296555.5_Missense_Mutation_p.H382R|FBXW7_ENST00000603548.1_Missense_Mutation_p.H500R|FBXW7_ENST00000603841.1_Missense_Mutation_p.H500R	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	500					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCTGCAACATGACCCATCAA	0.463			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								68	65					0	0	1	0	0	C	153247303	T	C	153247303	3	2	16	1	0	0	0	0	1	0	0	0	5801	1464	51	4	636	4	FBXW7	4	153247303	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	96399908	153247303	37906973	15	1079										
GABRB2	0	broad.mit.edu	37	chr5	160721270	160721270	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	atgtcgttccagagcatttcGgccaaaactatgcctgggca	10	11	0	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr5:160721270G>A	ENST00000274547.2	-	11	1574	c.1357C>T	c.(1357-1359)Cga>Tga	p.R453*	GABRB2_ENST00000517901.1_Nonsense_Mutation_p.R352*|GABRB2_ENST00000393959.1_Nonsense_Mutation_p.R453*|GABRB2_ENST00000517547.1_Nonsense_Mutation_p.R255*|GABRB2_ENST00000520240.1_Nonsense_Mutation_p.R415*|GABRB2_ENST00000353437.6_Nonsense_Mutation_p.R415*	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	453					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGAGCATTTCGGCCAAAACTA	0.532													47	48					0	0	1	0	0	A	160721270	G	A	160721270	4	1	16	1	0	0	0	0	0	1	0	0	6201	1124	39	1	185	1	GABRB2	5	160721270	Nonsense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		160721270	20193990	16	1080										
DSP	1832	broad.mit.edu	37	chr6	7585589	7585589	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	cagaaagccttcataggcttCgagggtgtgaagggaaagaa	14	6	1	3			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr6:7585589C>T	ENST00000379802.3	+	24	8435	c.8094C>T	c.(8092-8094)ttC>ttT	p.F2698F	DSP_ENST00000418664.2_Silent_p.F2099F	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2698	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCATAGGCTTCGAGGGTGTGA	0.557													65	243					0	0	1	0	0	T	7585589	C	T	7585589	2	4	16	1	0	0	0	0	0	0	0	1	4807	883	31	1		1	DSP	6	7585589	Silent	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		7585589	163529478	17	1081										
NFKBIL1	4795	broad.mit.edu	37	chr6	31526160	31526160	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtgccctggccctgccctggGggaggggacccagaggccat	17	14	0	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr6:31526160G>A	ENST00000376148.4	+	4	1032	c.918G>A	c.(916-918)ggG>ggA	p.G306G	NFKBIL1_ENST00000376145.4_Silent_p.G291G	NM_005007.3	NP_004998.3	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	306					cytoplasmic sequestering of transcription factor		protein binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7						CCTGCCCTGGGGGAGGGGACC	0.697													4	6					0	0	1	0	0	A	31526160	G	A	31526160	2	1	16	1	0	0	0	0	0	0	0	1	10427	1219	43	3		3	NFKBIL1	6	31526160	Silent	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	23940571	31526160	139588907	18	1082										
LPA	4018	broad.mit.edu	37	chr6	160977179	160977179	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	taactctggccattaccatgGtagcactgccggaccacagg	10	13	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr6:160977179G>A	ENST00000447678.1	-	31	4971	c.4851C>T	c.(4849-4851)taC>taT	p.Y1617Y	LPA_ENST00000316300.5_Silent_p.Y1617Y	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4125	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CATTACCATGGTAGCACTGCC	0.468													36	77					0	0	1	0	0	A	160977179	G	A	160977179	2	1	16	1	0	0	0	0	0	0	0	1	8947	1256	44	3		3	LPA	6	160977179	Silent	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	129451019	160977179	10137888	19	1083										
THSD7A	221981	broad.mit.edu	37	chr7	11676068	11676068	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctggattggcacacctggaaCtccgtcaggtttggacagcc	12	12	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr7:11676068C>G	ENST00000423059.3	-	2	962	c.711G>C	c.(709-711)gaG>gaC	p.E237D		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	237	TSP type-1 2.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACACCTGGAACTCCGTCAGGT	0.657										HNSCC(18;0.044)			13	16					0	0	1	0	0	G	11676068	C	G	11676068	3	3	16	1	0	0	0	0	1	0	0	0	15938	564	20	5	4366	5	THSD7A	7	11676068	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		11676068	147462595	20	1084										
KRIT1	889	broad.mit.edu	37	chr7	91851246	91851246	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acttccaagggaagtctcacAtctcttcttagaaaaagctg	7	10	3	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr7:91851246A>T	ENST00000394507.1	-	15	2316	c.1533T>A	c.(1531-1533)gaT>gaA	p.D511E	KRIT1_ENST00000394503.2_Missense_Mutation_p.D463E|KRIT1_ENST00000394505.2_Missense_Mutation_p.D511E|KRIT1_ENST00000412043.2_Missense_Mutation_p.D511E|KRIT1_ENST00000340022.2_Missense_Mutation_p.D511E	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	511	FERM.|Required for RAP1A binding.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAGTCTCACATCTCTTCTTA	0.368													3	21					0	0	1	0	0	T	91851246	A	T	91851246	3	4	16	1	0	0	0	0	1	0	0	0	8487	214	8	4	701	4	KRIT1	7	91851246	Missense_Mutation	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08	80175178	91851246	67287417	21	1085										
POTEA	340441	broad.mit.edu	37	chr8	43157250	43157250	+	RNA	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgcagtttctagtcatcataGtatgtaagtgtttacattaa	7	5	3	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr8:43157250G>A	ENST00000522175.2	+	0	697							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGTCATCATAGTATGTAAGTG	0.289													3	31					0	0	1	0	0	A	43157250	G	A	43157250	1	1	16	0	1	0	0	0	0	0	0	0	12308	1029	36	3		3	POTEA	8	43157250	RNA	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		43157250	103206772	22	1086										
EXOSC3	51010	broad.mit.edu	37	chr9	37785000	37785000	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cgtgcagcgcgcgccctgctGcccgcgagagattcagccgc	14	17	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr9:37785000G>A	ENST00000327304.5	-	1	54	c.42C>T	c.(40-42)ggC>ggT	p.G14G	RP11-613M10.9_ENST00000540557.1_Intron|EXOSC3_ENST00000396521.3_Silent_p.G14G	NM_016042.3	NP_057126.2	Q9NQT5	EXOS3_HUMAN	exosome component 3	14					CUT catabolic process|DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|isotype switching|rRNA processing	cytoplasmic exosome (RNase complex)|cytosol|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding			breast(2)|endometrium(1)|kidney(1)	4				GBM - Glioblastoma multiforme(29;0.00771)|Lung(182;0.221)		GCGCCCTGCTGCCCGCGAGAG	0.682													29	2					0	0	1	0	0	A	37785000	G	A	37785000	2	1	16	1	0	0	0	0	0	0	0	1	5343	1306	46	3		3	EXOSC3	9	37785000	Silent	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		37785000	103428431	23	1087										
FCN1	2219	broad.mit.edu	37	chr9	137808192	137808192	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tccccacccggcccgcacctAcctctctctccaatgacacc	4	23	2	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr9:137808192A>G	ENST00000371806.3	-	2	309		c.e2+1			NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1						opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GCCCGCACCTACCTCTCTCTC	0.657													17	238					0	0	1	0	0	G	137808192	A	G	137808192	5	3	16	1	0	0	0	0	0	0	1	0	5823	405	14	4	793	4	FCN1	9	137808192	Splice_Site	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08	100023192	137808192	3405239	24	1088										
NHLRC2	374354	broad.mit.edu	37	chr10	115663478	115663478	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttaaagtgatggatttagaaActaaaatggtatctgtggta	10	2	1	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr10:115663478A>G	ENST00000369301.3	+	9	1899	c.1687A>G	c.(1687-1689)Act>Gct	p.T563A		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	563					cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		GGATTTAGAAACTAAAATGGT	0.308													82	74					0	0	1	0	0	G	115663478	A	G	115663478	3	3	16	1	0	0	0	0	1	0	0	0	10452	43	2	4	1721	4	NHLRC2	10	115663478	Missense_Mutation	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08		115663478	19871269	25	1089										
MTCH2	23788	broad.mit.edu	37	chr11	47652148	47652148	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tcttcccgatagatggttatTatggaatcacaaagtccact	7	9	2	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr11:47652148T>C	ENST00000302503.3	-	8	655	c.498A>G	c.(496-498)atA>atG	p.I166M	MTCH2_ENST00000542981.1_Missense_Mutation_p.I18M	NM_014342.3	NP_055157.1	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	166					transport	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	11						AGATGGTTATTATGGAATCAC	0.328													3	61					0	0	1	0	0	C	47652148	T	C	47652148	3	2	16	1	0	0	0	0	1	0	0	0	9961	1744	61	4	437	4	MTCH2	11	47652148	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08		47652148	87354368	26	1090										
PACS1	55690	broad.mit.edu	37	chr11	66002813	66002813	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gggtgatgcagtacgtcaacGgggcagccacgacacaccag	14	12	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr11:66002813G>A	ENST00000320580.4	+	18	2179	c.2146G>A	c.(2146-2148)Ggg>Agg	p.G716R	PACS1_ENST00000529757.1_Missense_Mutation_p.G252R	NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	716					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						GTACGTCAACGGGGCAGCCAC	0.532													38	6					0	0	1	0	0	A	66002813	G	A	66002813	3	1	16	1	0	0	0	0	1	0	0	0	11418	1116	39	1	2216	1	PACS1	11	66002813	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	18350665	66002813	69003703	27	1091										
SLCO1B3	28234	broad.mit.edu	37	chr12	21032378	21032378	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttttatttctaggaatcataAccattcctacggttgcaact	5	9	2	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr12:21032378A>C	ENST00000381545.3	+	11	1363	c.1144A>C	c.(1144-1146)Acc>Ccc	p.T382P	SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.T382P|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.T382P|LST3_ENST00000540229.1_Missense_Mutation_p.T382P|LST3_ENST00000381541.3_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	382					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					AGGAATCATAACCATTCCTAC	0.269													6	46					0	0	1	0	0	C	21032378	A	C	21032378	3	2	16	1	0	0	0	0	1	0	0	0	14778	43	2	4	1178	4	SLCO1B3	12	21032378	Missense_Mutation	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08		21032378	112819517	28	1092										
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	18					0	0	1	0	0	T	25398284	C	T	25398284	3	4	16	1	0	0	0	0	1	0	0	0	8480	507	18	3	671	3	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	4365906	25398284	108453611	29	1093										
SMARCC2	6601	broad.mit.edu	37	chr12	56563467	56563467	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cttcctttggctccttctccTtctcaggatcgactgggcca	8	15	2	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr12:56563467T>C	ENST00000394023.3	-	25	2666	c.2561A>G	c.(2560-2562)aAg>aGg	p.K854R	SMARCC2_ENST00000347471.4_Missense_Mutation_p.K854R|SMARCC2_ENST00000550164.1_Missense_Mutation_p.K854R|SMARCC2_ENST00000267064.4_Missense_Mutation_p.K823R|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	823	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			ctccttctccttctcAGGATC	0.592													22	42					0	0	1	0	0	C	56563467	T	C	56563467	3	2	16	1	0	0	0	0	1	0	0	0	14829	1609	56	4	1196	4	SMARCC2	12	56563467	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	31165183	56563467	77288428	30	1094										
ZFC3H1	196441	broad.mit.edu	37	chr12	72030371	72030371	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gactattgatagattgcttcTtggcacaggatgtgaattgt	11	5	1	3			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr12:72030371T>A	ENST00000378743.3	-	9	2357	c.1999A>T	c.(1999-2001)Aga>Tga	p.R667*		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	667					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGATTGCTTCTTGGCACAGGA	0.418													16	82					0	0	1	0	0	A	72030371	T	A	72030371	4	1	16	1	0	0	0	0	0	1	0	0	17690	1617	56	4	4078	4	ZFC3H1	12	72030371	Nonsense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	15466904	72030371	61821524	31	1095										
FANCM	57697	broad.mit.edu	37	chr14	45623210	45623210	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tattgcagcaaatgggaatgAgatcattatatttcttcctt	7	6	2	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr14:45623210A>C	ENST00000267430.5	+	6	1223	c.1138A>C	c.(1138-1140)Aga>Cga	p.R380R	FANCM_ENST00000542564.2_Silent_p.R354R|FANCM_ENST00000556036.1_Silent_p.R380R	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	380					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						AATGGGAATGAGATCATTATA	0.294								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				49	11					0	0	1	0	0	C	45623210	A	C	45623210	2	2	16	1	0	0	0	0	0	0	0	1	5703	296	11	4		4	FANCM	14	45623210	Silent	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08		45623210	61726330	32	1096										
NTN3	4917	broad.mit.edu	37	chr16	2522127	2522127	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	caagtctcaggaccatggccGcagctgggccccgctgggct	14	15	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr16:2522127G>A	ENST00000293973.1	+	1	628	c.425G>A	c.(424-426)cGc>cAc	p.R142H		NM_006181.2	NP_006172.1	O00634	NET3_HUMAN	netrin 3	142	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				breast(1)|central_nervous_system(2)|lung(3)|prostate(1)	7						GACCATGGCCGCAGCTGGGCC	0.677													3	40					0	0	1	0	0	A	2522127	G	A	2522127	3	1	16	1	0	0	0	0	1	0	0	0	10748	1087	38	1	427	1	NTN3	16	2522127	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		2522127	87832626	33	1097										
ASPHD1	253982	broad.mit.edu	37	chr16	29917116	29917116	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccatgtgccctaggctccccCgaagatgggcctcgagtggt	13	14	0	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr16:29917116C>T	ENST00000308748.5	+	3	1323	c.1071C>T	c.(1069-1071)ccC>ccT	p.P357P	ASPHD1_ENST00000483405.1_Silent_p.P76P	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	357					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						TAGGCTCCCCCGAAGATGGGC	0.572													19	54					0	0	1	0	0	T	29917116	C	T	29917116	2	4	16	1	0	0	0	0	0	0	0	1	1053	639	23	1		1	ASPHD1	16	29917116	Silent	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	27394989	29917116	60437637	34	1098										
SETD1A	9739	broad.mit.edu	37	chr16	30977316	30977316	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	attgattgccgcctcagctgGcccccccggtggggcctttg	13	15	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr16:30977316G>A	ENST00000262519.8	+	8	2800	c.2114G>A	c.(2113-2115)gGc>gAc	p.G705D		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GCCTCAGCTGGCCCCCCCGGT	0.642													40	134					0	0	1	0	0	A	30977316	G	A	30977316	3	1	16	1	0	0	0	0	1	0	0	0	14183	1203	42	3	2140	3	SETD1A	16	30977316	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	1060200	30977316	59377437	35	1099										
IRX6	79190	broad.mit.edu	37	chr16	55362678	55362678	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ggaagacctggaggaagaggAggaggaggaggaggaagctg	22	3	0	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr16:55362678A>G	ENST00000290552.7	+	5	2120	c.788A>G	c.(787-789)gAg>gGg	p.E263G	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	263						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						gaggaagaggaggaggaggag	0.627													29	35					0	0	1	0	0	G	55362678	A	G	55362678	3	3	16	1	0	0	0	0	1	0	0	0	7891	304	11	4	806	4	IRX6	16	55362678	Missense_Mutation	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08	24385362	55362678	34992075	36	1100										
LDHD	197257	broad.mit.edu	37	chr16	75149480	75149480	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	atcgcgcccgtgctgctctcGgaccaccgcggcagtggaca	13	16	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr16:75149480G>C	ENST00000300051.4	-	2	197	c.151C>G	c.(151-153)Cga>Gga	p.R51G	LDHD_ENST00000450168.2_Missense_Mutation_p.R51G	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	51							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						TGCTGCTCTCGGACCACCGCG	0.652													7	34					0	0	1	0	0	C	75149480	G	C	75149480	3	2	16	1	0	0	0	0	1	0	0	0	8741	1124	39	5	1412	5	LDHD	16	75149480	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	19786802	75149480	15205273	37	1101										
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	12	8	0	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr17:7577568C>T	ENST00000420246.2	-	7	845	c.713G>A	c.(712-714)tGt>tAt	p.C238Y	TP53_ENST00000445888.2_Missense_Mutation_p.C238Y|TP53_ENST00000455263.2_Missense_Mutation_p.C238Y|TP53_ENST00000413465.2_Missense_Mutation_p.C238Y|TP53_ENST00000359597.4_Missense_Mutation_p.C238Y|TP53_ENST00000269305.4_Missense_Mutation_p.C238Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	238	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(65)|p.C238F(46)|p.C238S(9)|p.0?(8)|p.?(5)|p.C145F(5)|p.C145Y(5)|p.M237_N239delMCN(4)|p.C238fs*21(1)|p.M237fs*1(1)|p.M144_N146delMCN(1)|p.C238del(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.H233fs*6(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.C145S(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			74	11					0	0	1	0	0	T	7577568	C	T	7577568	3	4	16	1	0	0	0	0	1	0	0	0	16441	478	17	3	577	3	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		7577568	73617642	38	1102										
DNAH2	146754	broad.mit.edu	37	chr17	7689631	7689631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccctgtcctctctgtgccgcGccggagaccctaacttcaac	8	18	2	1	rs139080127		TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr17:7689631G>A	ENST00000572933.1	+	40	7779	c.6319G>A	c.(6319-6321)Gcc>Acc	p.A2107T	DNAH2_ENST00000389173.2_Missense_Mutation_p.A2107T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2107	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCTGTGCCGCGCCGGAGACCC	0.597													15	48					0	0	1	0	0	A	7689631	G	A	7689631	3	1	16	1	0	0	0	0	1	0	0	0	4630	1087	38	1	6473	1	DNAH2	17	7689631	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	112063	7689631	73505579	39	1103										
WNT9B	7484	broad.mit.edu	37	chr17	44953961	44953961	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgcagcagcctgtgctgcggGcggggctatgacacccagag	16	12	0	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr17:44953961G>A	ENST00000290015.2	+	4	1004	c.951G>A	c.(949-951)ggG>ggA	p.G317G	WNT9B_ENST00000393461.2_Intron	NM_003396.1	NP_003387.1	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	317					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			TGTGCTGCGGGCGGGGCTATG	0.662													81	11					0	0	1	0	0	A	44953961	G	A	44953961	2	1	16	1	0	0	0	0	0	0	0	1	17458	1190	42	3		3	WNT9B	17	44953961	Silent	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	37264330	44953961	36241249	40	1104										
SPOP	8405	broad.mit.edu	37	chr17	47696408	47696408	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctcatccaaaagaaaatctcTacggatgaatttcttgaatc	5	9	3	3			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr17:47696408T>C	ENST00000393331.3	-	7	885	c.415A>G	c.(415-417)Aga>Gga	p.R139G	SPOP_ENST00000503676.1_Missense_Mutation_p.R139G|SPOP_ENST00000504102.1_Missense_Mutation_p.R139G|SPOP_ENST00000393328.2_Missense_Mutation_p.R139G|SPOP_ENST00000347630.2_Missense_Mutation_p.R139G	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	139	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						AGAAAATCTCTACGGATGAAT	0.463										Prostate(2;0.17)			132	25					0	0	1	0	0	C	47696408	T	C	47696408	3	2	16	1	0	0	0	0	1	0	0	0	15139	1530	53	4	733	4	SPOP	17	47696408	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	2742447	47696408	33498802	41	1105										
SPOP	8405	broad.mit.edu	37	chr17	47699375	47699375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gacttcacccatttcctcccGgcaaaagctaaagttattga	6	12	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr17:47699375G>A	ENST00000393331.3	-	5	603	c.133C>T	c.(133-135)Cgg>Tgg	p.R45W	SPOP_ENST00000503676.1_Missense_Mutation_p.R45W|SPOP_ENST00000504102.1_Missense_Mutation_p.R45W|SPOP_ENST00000513080.1_5'UTR|SPOP_ENST00000393328.2_Missense_Mutation_p.R45W|SPOP_ENST00000347630.2_Missense_Mutation_p.R45W	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	45	MATH.				mRNA processing	nucleus	protein binding	p.R45W(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						ATTTCCTCCCGGCAAAAGCTA	0.358										Prostate(2;0.17)			30	5					0	0	1	0	0	A	47699375	G	A	47699375	3	1	16	1	0	0	0	0	1	0	0	0	15139	1115	39	1	1023	1	SPOP	17	47699375	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	2967	47699375	33495835	42	1106										
SALL3	27164	broad.mit.edu	37	chr18	76752234	76752234	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0	0	1	0	0	0	1	1	0	aagctcccgcccgtgctgatCgtgcacgaggacgcgcccgc	13	17	0	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr18:76752234C>G	ENST00000575389.2	+	2	243	c.243C>G	c.(241-243)atC>atG	p.I81M	SALL3_ENST00000537592.2_Missense_Mutation_p.I81M|SALL3_ENST00000536229.3_5'UTR			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCGTGCTGATCGTGCACGAGG	0.711													5	25					0	0	1	0	0	G	76752234	C	G	76752234	3	3	16	1	0	0	0	0	1	0	0	0	13863	874	31	2	249	2	SALL3	18	76752234	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		76752234	1325014	43	1107										
DOCK6	57572	broad.mit.edu	37	chr19	11327692	11327692	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cgctgcaggagcgccggctcGgtgtttttcagcacccacag	13	14	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr19:11327692G>A	ENST00000294618.7	-	30	3803	c.3792C>T	c.(3790-3792)acC>acT	p.T1264T	DOCK6_ENST00000319867.7_Silent_p.T603T	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1264					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						GCGCCGGCTCGGTGTTTTTCA	0.612													22	60					0	0	1	0	0	A	11327692	G	A	11327692	2	1	16	1	0	0	0	0	0	0	0	1	4718	1103	39	1		1	DOCK6	19	11327692	Silent	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		11327692	47801291	44	1108										
ZNF99	7652	broad.mit.edu	37	chr19	22939890	22939890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	tatgtttcttaagggttgagGaattgttaaaagcttttcca	9	4	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr19:22939890G>A	ENST00000397104.3	-	6	2440	c.2441C>T	c.(2440-2442)tCc>tTc	p.S814F						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGGGTTGAGGAATTGTTAAA	0.383													35	37					0	0	1	0	0	A	22939890	G	A	22939890	3	1	16	1	0	0	0	0	1	0	0	0	18245	1174	41	3	679	3	ZNF99	19	22939890	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	11612198	22939890	36189093	45	1109										
VN1R2	317701	broad.mit.edu	37	chr19	53762414	53762414	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gaagtcacaaagtcagtataTgcagcattgacatccttcca	7	10	2	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr19:53762414T>A	ENST00000341702.3	+	1	870	c.786T>A	c.(784-786)taT>taA	p.Y262*		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	262					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		AGTCAGTATATGCAGCATTGA	0.448													79	21					0	0	1	0	0	A	53762414	T	A	53762414	4	1	16	1	0	0	0	0	0	1	0	0	17238	1471	51	4	788	4	VN1R2	19	53762414	Nonsense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	30822524	53762414	5366569	46	1110										
FOXA2	3170	broad.mit.edu	37	chr20	22563665	22563665	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgccagcgcccacgtacgacGacatgttcatggagcccgcg	12	15	1	0			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr20:22563665G>T	ENST00000419308.2	-	2	399	c.197C>A	c.(196-198)tCg>tAg	p.S66*	FOXA2_ENST00000319993.4_Nonsense_Mutation_p.S72*|FOXA2_ENST00000377115.4_Nonsense_Mutation_p.S66*	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	66	Transactivation domain 1 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					CACGTACGACGACATGTTCAT	0.731													62	41					1.1362e-29	1.27392e-29	1	1	0	T	22563665	G	T	22563665	4	4	16	1	0	0	0	0	0	1	0	0	6022	1059	37	2	1180	2	FOXA2	20	22563665	Nonsense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08		22563665	40461855	47	1111										
DSCAM	1826	broad.mit.edu	37	chr21	41648105	41648105	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gaggtagtagccactgtcttCctccacgacatgcttgatca	9	12	2	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr21:41648105C>A	ENST00000400454.1	-	11	2752	c.2275G>T	c.(2275-2277)Gaa>Taa	p.E759*		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	759	Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCACTGTCTTCCTCCACGACA	0.517													23	23					6.44725e-10	6.81567e-10	1	1	0	A	41648105	C	A	41648105	4	1	16	1	0	0	0	0	0	1	0	0	4794	864	30	2	3855	2	DSCAM	21	41648105	Nonsense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		41648105	6481790	48	1112										
KLHDC7B	113730	broad.mit.edu	37	chr22	50988123	50988123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gcgtgggcgccgccgtgatgCgctacaacacagtgaccggc	15	14	0	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chr22:50988123C>T	ENST00000395676.2	+	1	1662	c.1528C>T	c.(1528-1530)Cgc>Tgc	p.R510C		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	510										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGCCGTGATGCGCTACAACAC	0.692													10	67					0	0	1	0	0	T	50988123	C	T	50988123	3	4	16	1	0	0	0	0	1	0	0	0	8403	768	27	1	1530	1	KLHDC7B	22	50988123	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		50988123	316443	49	1113										
MID1	0	broad.mit.edu	37	chrX	10417566	10417566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gttcaaagcatcataaaaggCgatagagccgttatcatagt	9	7	3	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:10417566C>T	ENST00000317552.4	-	10	2246	c.1846G>A	c.(1846-1848)Gcc>Acc	p.A616T	MID1_ENST00000479925.1_5'UTR|MID1_ENST00000380787.1_Missense_Mutation_p.A616T|MID1_ENST00000453318.2_Missense_Mutation_p.A616T|MID1_ENST00000380779.1_Missense_Mutation_p.A616T|MID1_ENST00000380780.1_Missense_Mutation_p.A616T|MID1_ENST00000380782.2_3'UTR|MID1_ENST00000380785.1_Missense_Mutation_p.A616T	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	616	B30.2/SPRY.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						TCATAAAAGGCGATAGAGCCG	0.547													94	88					0	0	1	0	0	T	10417566	C	T	10417566	3	4	16	1	0	0	0	0	1	0	0	0	9623	768	27	1	161	1	MID1	23	10417566	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08		10417566	144852994	50	1114										
HCCS	3052	broad.mit.edu	37	chrX	11139870	11139870	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctggacgtccgtcctgccttAgattcactttcggcagtatg	10	12	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:11139870A>G	ENST00000321143.4	+	7	949	c.747A>G	c.(745-747)ttA>ttG	p.L249L	ARHGAP6_ENST00000534860.1_Intron|HCCS_ENST00000380763.3_Silent_p.L249L|HCCS_ENST00000380762.4_Silent_p.L249L	NM_001122608.2|NM_001171991.2|NM_005333.4	NP_001116080.1|NP_001165462.1|NP_005324.3	P53701	CCHL_HUMAN	holocytochrome c synthase	249					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)	7						GTCCTGCCTTAGATTCACTTT	0.433													5	62					0	0	1	0	0	G	11139870	A	G	11139870	2	3	16	1	0	0	0	0	0	0	0	1	7030	417	15	4		4	HCCS	23	11139870	Silent	SNP	A	TCGA-N6-A4VC-01A-11D-A28R-08	722304	11139870	144130690	51	1115										
FAM47C	442444	broad.mit.edu	37	chrX	37028481	37028481	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aagactcgggtgtccagtctCcccccggagccccccgagac	11	18	1	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:37028481C>A	ENST00000358047.3	+	1	2050	c.1998C>A	c.(1996-1998)ctC>ctA	p.L666L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	666										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGTCCAGTCTCCCCCCGGAGC	0.637													12	104					8.60227e-14	9.3613e-14	1	1	0	A	37028481	C	A	37028481	2	1	16	1	0	0	0	0	0	0	0	1	5606	842	30	2		2	FAM47C	23	37028481	Silent	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	25888611	37028481	118242079	52	1116										
SLC38A5	92745	broad.mit.edu	37	chrX	48317963	48317963	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gaaaggctccacctcagaggGtacaatgcggaggtagaaga	14	8	1	3			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:48317963G>T	ENST00000376876.3	-	15	2119	c.1276C>A	c.(1276-1278)Ccc>Acc	p.P426T	SLC38A5_ENST00000317669.5_Missense_Mutation_p.P426T|SLC38A5_ENST00000376875.1_Missense_Mutation_p.P375T|SLC38A5_ENST00000480105.1_5'UTR			Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	426					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				breast(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	19						ACCTCAGAGGGTACAATGCGG	0.567													6	16					0.00307968	0.00312187	1	1	0	T	48317963	G	T	48317963	3	4	16	1	0	0	0	0	1	0	0	0	14661	1261	44	5	150	5	SLC38A5	23	48317963	Missense_Mutation	SNP	G	TCGA-N6-A4VC-01A-11D-A28R-08	11289482	48317963	106952597	53	1117										
TAF1	6872	broad.mit.edu	37	chrX	70607293	70607293	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tccaaaagggccaatacgcaTattcgagactttctacaggt	8	10	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:70607293T>C	ENST00000449580.1	+	15	2457	c.2406T>C	c.(2404-2406)caT>caC	p.H802H	TAF1_ENST00000276072.3_Silent_p.H823H|TAF1_ENST00000373790.4_Silent_p.H802H|TAF1_ENST00000423759.1_Silent_p.H823H			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	802					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				CCAATACGCATATTCGAGACT	0.488													9	77					0	0	1	0	0	C	70607293	T	C	70607293	2	2	16	1	0	0	0	0	0	0	0	1	15569	1403	49	4		4	TAF1	23	70607293	Silent	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	22289330	70607293	84663267	54	1118										
ABCB7	22	broad.mit.edu	37	chrX	74334628	74334628	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgtcctgaattgccttttccCaatctctgccatgtgatact	6	12	1	2			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:74334628C>A	ENST00000253577.3	-	2	234	c.210G>T	c.(208-210)ttG>ttT	p.L70F	ABCB7_ENST00000373394.3_Missense_Mutation_p.L69F|ABCB7_ENST00000339447.4_Missense_Mutation_p.L69F	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	69					cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						TGCCTTTTCCCAATCTCTGCC	0.378													5	21					1.23904e-05	1.29139e-05	1	1	0	A	74334628	C	A	74334628	3	1	16	1	0	0	0	0	1	0	0	0	46	593	21	5	2111	5	ABCB7	23	74334628	Missense_Mutation	SNP	C	TCGA-N6-A4VC-01A-11D-A28R-08	3727335	74334628	80935932	55	1119										
KLHL4	0	broad.mit.edu	37	chrX	86888868	86888868	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ggaattacgtagccagtatgTcaactcctagaagcacagtt	9	9	1	1			TCGA-N6-A4VC-01A-11D-A28R-08	TCGA-N6-A4VC-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3fadc22-cfbf-4cba-957e-5a792cafcd32	1e474ebc-3552-4fb7-8ee8-8d0df5c67f3b	g.chrX:86888868T>G	ENST00000373119.4	+	8	1814	c.1669T>G	c.(1669-1671)Tca>Gca	p.S557A	KLHL4_ENST00000373114.4_Missense_Mutation_p.S557A	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	557						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AGCCAGTATGTCAACTCCTAG	0.423													4	54					0	0	1	0	0	G	86888868	T	G	86888868	3	3	16	1	0	0	0	0	1	0	0	0	8433	1667	58	4	1699	4	KLHL4	23	86888868	Missense_Mutation	SNP	T	TCGA-N6-A4VC-01A-11D-A28R-08	12554240	86888868	68381692	56	1120										
SLC6A9	6536	broad.mit.edu	37	chr1	44474144	44474144	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttggaggcgtccagtacaccGgcgcagtcatgcgtgttcca	13	12	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:44474144G>A	ENST00000372310.3	-	5	636	c.471C>T	c.(469-471)gcC>gcT	p.A157A	SLC6A9_ENST00000372306.3_Silent_p.A157A|SLC6A9_ENST00000475075.2_Silent_p.A46A|SLC6A9_ENST00000372307.3_Silent_p.A92A|SLC6A9_ENST00000360584.2_Silent_p.A230A|SLC6A9_ENST00000537678.1_Silent_p.A92A|SLC6A9_ENST00000357730.2_Silent_p.A176A	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	230						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity	p.A230A(1)|p.A157A(1)		endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CCAGTACACCGGCGCAGTCAT	0.607													34	58					0	0	1	0	0	A	44474144	G	A	44474144	2	1	17	1	0	0	0	0	0	0	0	1	14745	1103	39	1		1	SLC6A9	1	44474144	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		44474144	204776477	1	1121										
PLK3	1263	broad.mit.edu	37	chr1	45268952	45268952	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ctccctagggctacacccccGatcgactccctatcagcagc	7	19	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:45268952G>A	ENST00000372201.4	+	8	1200	c.961G>A	c.(961-963)Gat>Aat	p.D321N	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	321						membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					CTACACCCCCGATCGACTCCC	0.577													29	45					0	0	1	0	0	A	45268952	G	A	45268952	3	1	17	1	0	0	0	0	1	0	0	0	12144	1058	37	1	991	1	PLK3	1	45268952	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	794808	45268952	203981669	2	1122										
C1orf168	199920	broad.mit.edu	37	chr1	57206384	57206384	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttttaccttaagttttctttCgacttggttttctttatttt	4	6	2	0	rs140363025		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:57206384C>T	ENST00000343433.6	-	13	1769	c.1689G>A	c.(1687-1689)tcG>tcA	p.S563S	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	563										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						AGTTTTCTTTCGACTTGGTTT	0.363													7	13					0	0	1	0	0	T	57206384	C	T	57206384	2	4	17	1	0	0	0	0	0	0	0	1	2025	871	31	1		1	C1orf168	1	57206384	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	11937432	57206384	192044237	3	1123										
FCRL4	83417	broad.mit.edu	37	chr1	157551320	157551320	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ggcaaagaaaagagcacaaaCctgacttcctccgacgccag	9	13	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:157551320C>T	ENST00000271532.1	-	7	1385		c.e7+1		FCRL4_ENST00000448509.2_Splice_Site	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4							integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AGAGCACAAACCTGACTTCCT	0.597													24	29					0	0	1	0	0	T	157551320	C	T	157551320	5	4	17	1	0	0	0	0	0	0	1	0	5829	521	18	3	321	3	FCRL4	1	157551320	Splice_Site	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	100344936	157551320	91699301	4	1124										
SPTA1	6708	broad.mit.edu	37	chr1	158618428	158618428	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttcttctcaatctgctccttCgtgtcatctgcttctctggt	6	13	6	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:158618428C>T	ENST00000368148.3	-	26	3765	c.3585G>A	c.(3583-3585)acG>acA	p.T1195T	SPTA1_ENST00000368147.3_Silent_p.T1195T	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1195					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCTGCTCCTTCGTGTCATCTG	0.498													37	39					0	0	1	0	0	T	158618428	C	T	158618428	2	4	17	1	0	0	0	0	0	0	0	1	15171	871	31	1		1	SPTA1	1	158618428	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	1067108	158618428	90632193	5	1125										
RPS6KC1	26750	broad.mit.edu	37	chr1	213302876	213302876	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gatcatatttctaggcttctCcagtgacagtgatctggtat	9	8	4	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:213302876C>T	ENST00000366960.3	+	6	629	c.479C>T	c.(478-480)tCc>tTc	p.S160F	RPS6KC1_ENST00000366959.3_Missense_Mutation_p.S148F|RPS6KC1_ENST00000543354.1_Intron|RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543470.1_5'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	160					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTAGGCTTCTCCAGTGACAGT	0.333													21	43					0	0	1	0	0	T	213302876	C	T	213302876	3	4	17	1	0	0	0	0	1	0	0	0	13709	855	30	3	501	3	RPS6KC1	1	213302876	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	54684448	213302876	35947745	6	1126										
IARS2	55699	broad.mit.edu	37	chr1	220287663	220287664	+	Frame_Shift_Ins	INS	-	-	A													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aattaattgcaggaattgttINSaaaaaaggtgaaatttattc							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:220287663_220287664insA	ENST00000366922.1	+	12	1602_1603	c.1271_1272insA	c.(1270-1272)taafs	p.*424fs	IARS2_ENST00000302637.5_Frame_Shift_Ins_p.*496fs			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	496					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CAGGAATTGTTAAAAAAGGTGA	0.366													22	59	---	---	---	---						A	220287664	-	A	220287663	7	5	17	1	0	1	1	0	0	0	0	0	7517	1764	61	0	1533	0	IARS2	1	220287663	Frame_Shift_Ins	INS	-	TCGA-N6-A4VD-01A-11D-A28R-08	6984787	220287663	28962958	7	1127										
FMN2	56776	broad.mit.edu	37	chr1	240371620	240371620	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ccccacctccccctctacccGgagcgggcataccccctccg	7	24	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:240371620G>A	ENST00000319653.9	+	5	3738	c.3508G>A	c.(3508-3510)Gga>Aga	p.G1170R		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1170	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCTCTACCCGGAGCGGGCAT	0.692													6	15					0	0	1	0	0	A	240371620	G	A	240371620	3	1	17	1	0	0	0	0	1	0	0	0	5982	1117	39	1	3526	1	FMN2	1	240371620	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	20083957	240371620	8879001	8	1128										
TPO	7173	broad.mit.edu	37	chr2	1457506	1457506	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cctccaacacggccctggcaCgatggctccctccagtctat	8	18	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:1457506C>T	ENST00000345913.4	+	6	614	c.523C>T	c.(523-525)Cga>Tga	p.R175*	TPO_ENST00000382198.1_Nonsense_Mutation_p.R175*|TPO_ENST00000497517.2_Intron|TPO_ENST00000382201.3_Nonsense_Mutation_p.R175*|TPO_ENST00000329066.4_Nonsense_Mutation_p.R175*|TPO_ENST00000349624.3_Nonsense_Mutation_p.R175*|TPO_ENST00000346956.3_Nonsense_Mutation_p.R175*|TPO_ENST00000337415.3_Nonsense_Mutation_p.R175*	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	175					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGCCCTGGCACGATGGCTCCC	0.602													31	40					0	0	1	0	0	T	1457506	C	T	1457506	4	4	17	1	0	0	0	0	0	1	0	0	16470	528	19	1	541	1	TPO	2	1457506	Nonsense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		1457506	241741867	9	1129										
APOB	338	broad.mit.edu	37	chr2	21245884	21245884	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tgtcacaaactccacagacaCggagggttttgccaccagtt	9	12	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:21245884C>T	ENST00000233242.1	-	18	2762	c.2635G>A	c.(2635-2637)Gtg>Atg	p.V879M		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	879					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCACAGACACGGAGGGTTTT	0.478													25	43					0	0	1	0	0	T	21245884	C	T	21245884	3	4	17	1	0	0	0	0	1	0	0	0	782	536	19	1	11104	1	APOB	2	21245884	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	19788378	21245884	221953489	10	1130										
APOB	338	broad.mit.edu	37	chr2	21256329	21256329	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	agagtcttcaaaacagcttcGgcctgctttggaggtgatgt	12	8	2	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:21256329G>A	ENST00000233242.1	-	9	1093	c.966C>T	c.(964-966)gcC>gcT	p.A322A	APOB_ENST00000399256.4_Silent_p.A322A	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	322	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAACAGCTTCGGCCTGCTTTG	0.438													39	52					0	0	1	0	0	A	21256329	G	A	21256329	2	1	17	1	0	0	0	0	0	0	0	1	782	1103	39	1		1	APOB	2	21256329	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	10445	21256329	221943044	11	1131										
REG3G	130120	broad.mit.edu	37	chr2	79254978	79254978	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gggagtggagtagcactgatGtgatgaattactttgcatgg	15	4	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:79254978G>A	ENST00000272324.5	+	5	563	c.379G>A	c.(379-381)Gtg>Atg	p.V127M	REG3G_ENST00000409471.1_Missense_Mutation_p.V81M|REG3G_ENST00000393897.2_Missense_Mutation_p.V127M	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	127	C-type lectin.				acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TAGCACTGATGTGATGAATTA	0.498													47	73					0	0	1	0	0	A	79254978	G	A	79254978	3	1	17	1	0	0	0	0	1	0	0	0	13264	1377	48	3	393	3	REG3G	2	79254978	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	57998649	79254978	163944395	12	1132										
AFF3	3899	broad.mit.edu	37	chr2	100266099	100266099	+	Silent	SNP	A	A	T													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aaaatgtacctgtcagagagAgcgcggagagccgttctctg							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:100266099A>T	ENST00000317233.4	-	12	1408	c.1173T>A	c.(1171-1173)gcT>gcA	p.A391A	AFF3_ENST00000409579.1_Silent_p.A416A|AFF3_ENST00000409236.1_Silent_p.A391A|AFF3_ENST00000356421.2_Silent_p.A416A	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	391					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGTCAGAGAGAGCGCGGAGAG	0.368													19	59					0	0	1	0	0	T	100266099	A	T	100266099	2	4	17	1	0	0	0	0	0	0	0	1	357	291	11	4		4	AFF3	2	100266099	Silent	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	21011121	100266099	142933274	13	1133	7	2								
AFF3	3899	broad.mit.edu	37	chr2	100266101	100266101	+	Missense_Mutation	SNP	C	C	T													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aatgtacctgtcagagagagCgcggagagccgttctctgag							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:100266101C>T	ENST00000317233.4	-	12	1406	c.1171G>A	c.(1171-1173)Gct>Act	p.A391T	AFF3_ENST00000409579.1_Missense_Mutation_p.A416T|AFF3_ENST00000409236.1_Missense_Mutation_p.A391T|AFF3_ENST00000356421.2_Missense_Mutation_p.A416T	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	391					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TCAGAGAGAGCGCGGAGAGCC	0.363													18	60					0	0	1	0	0	T	100266101	C	T	100266101	3	4	17	1	0	0	0	0	1	0	0	0	357	768	27	1	2561	1	AFF3	2	100266101	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	2	100266101	142933272	14	1134	7	2								
CCDC148	130940	broad.mit.edu	37	chr2	159215037	159215037	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gttgatagtctactggtttgTacttgatgtttctcatctca	8	7	3	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:159215037T>C	ENST00000283233.5	-	2	384	c.71A>G	c.(70-72)tAc>tGc	p.Y24C	CCDC148_ENST00000409187.1_Missense_Mutation_p.Y33C|CCDC148_ENST00000409889.1_Missense_Mutation_p.Y24C|CCDC148_ENST00000536771.1_Intron	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	24										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TACTGGTTTGTACTTGATGTT	0.328													10	14					0	0	1	0	0	C	159215037	T	C	159215037	3	2	17	1	0	0	0	0	1	0	0	0	2800	1638	57	4	1808	4	CCDC148	2	159215037	Missense_Mutation	SNP	T	TCGA-N6-A4VD-01A-11D-A28R-08	58948936	159215037	83984336	15	1135										
PHOSPHO2	493911	broad.mit.edu	37	chr2	170557640	170557640	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tttatgggcagagtctttaaGtatttgggagataagggtgt	14	2	1	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:170557640G>A	ENST00000359744.3	+	4	547	c.159G>A	c.(157-159)aaG>aaA	p.K53K	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Intron	NM_001008489.3|NM_001199285.1|NM_001199286.1|NM_001199288.1	NP_001008489.1|NP_001186214.1|NP_001186215.1|NP_001186217.1	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	53							metal ion binding|pyridoxal phosphatase activity			breast(1)|large_intestine(1)|lung(6)|skin(2)	10						GAGTCTTTAAGTATTTGGGAG	0.383													30	32					0	0	1	0	0	A	170557640	G	A	170557640	2	1	17	1	0	0	0	0	0	0	0	1	11904	1020	36	3		3	PHOSPHO2	2	170557640	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	11342603	170557640	72641733	16	1136										
CD28	940	broad.mit.edu	37	chr2	204571286	204571286	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ccttgatcatgtgccctaagGggatggtggcggtggtggtg	18	7	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:204571286G>A	ENST00000458610.2	+	1	40	c.40G>A	c.(40-42)Ggg>Agg	p.G14R	CD28_ENST00000324106.7_5'UTR|CD28_ENST00000374481.3_5'UTR			P10747	CD28_HUMAN	CD28 molecule	0					cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						GTGCCCTAAGGGGATGGTGGC	0.532													3	9					0	0	1	0	0	A	204571286	G	A	204571286	3	1	17	1	0	0	0	0	1	0	0	0	3015	1247	43	3		3	CD28	2	204571286	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	34013646	204571286	38628087	17	1137										
STK16	8576	broad.mit.edu	37	chr2	220112473	220112473	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtcatcgatgagcggactgaTgtctgggtgaggagcatgtg	17	6	2	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:220112473T>A	ENST00000409638.3	+	6	823	c.651T>A	c.(649-651)gaT>gaA	p.D217E	STK16_ENST00000409260.1_Missense_Mutation_p.D262E|STK16_ENST00000409743.1_Intron|STK16_ENST00000396738.2_Missense_Mutation_p.D217E|STK16_ENST00000409516.3_Missense_Mutation_p.D99E	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	217	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCGGACTGATGTCTGGGTGA	0.587													5	4					0	0	1	0	0	A	220112473	T	A	220112473	3	1	17	1	0	0	0	0	1	0	0	0	15344	1461	51	4	669	4	STK16	2	220112473	Missense_Mutation	SNP	T	TCGA-N6-A4VD-01A-11D-A28R-08	15541187	220112473	23086900	18	1138										
GMPPA	29926	broad.mit.edu	37	chr2	220370460	220370460	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	atgtgtacatccacccgaccGccaaggtggccccctcggct	10	17	0	0	rs151043830		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:220370460G>A	ENST00000358215.3	+	10	1246	c.877G>A	c.(877-879)Gcc>Acc	p.A293T	AC053503.11_ENST00000429882.1_RNA|GMPPA_ENST00000341142.3_Missense_Mutation_p.A293T|GMPPA_ENST00000373908.1_Missense_Mutation_p.A293T|GMPPA_ENST00000373917.3_Missense_Mutation_p.A346T|GMPPA_ENST00000313597.5_Missense_Mutation_p.A293T	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	293					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CCACCCGACCGCCAAGGTGGC	0.607													18	27					0	0	1	0	0	A	220370460	G	A	220370460	3	1	17	1	0	0	0	0	1	0	0	0	6535	1087	38	1	911	1	GMPPA	2	220370460	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	257987	220370460	22828913	19	1139										
C2orf54	79919	broad.mit.edu	37	chr2	241829466	241829466	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtcagtctggccactgtcacGccagctctcgtggttgaccc	11	15	4	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:241829466G>A	ENST00000307486.8	-	3	501	c.403C>T	c.(403-405)Cgt>Tgt	p.R135C	C2orf54_ENST00000402775.2_Missense_Mutation_p.R116C|C2orf54_ENST00000388934.4_Missense_Mutation_p.R284C			Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	284										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		CCACTGTCACGCCAGCTCTCG	0.662													20	37					0	0	1	0	0	A	241829466	G	A	241829466	3	1	17	1	0	0	0	0	1	0	0	0	2189	1087	38	1	505	1	C2orf54	2	241829466	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	21459006	241829466	1369907	20	1140										
SCN5A	6331	broad.mit.edu	37	chr3	38592967	38592977	+	Frame_Shift_Del	DEL	GCGGCCTATTC	GCGGCCTATTC	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cctcggatcagtctgaggatGcggcctattcgggccaggcg							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:38592967_38592977delGCGGCCTATTC	ENST00000413689.1	-	28	5079_5089	c.4886_4896delGAATAGGCCGC	c.(4885-4896)cfs	p.RIGR1629fs	SCN5A_ENST00000455624.2_Frame_Shift_Del_p.RIGR1596fs|SCN5A_ENST00000425664.1_Frame_Shift_Del_p.RIGR1611fs|SCN5A_ENST00000414099.2_Frame_Shift_Del_p.RIGR1611fs|SCN5A_ENST00000451551.2_Frame_Shift_Del_p.RIGR1575fs|SCN5A_ENST00000333535.4_Frame_Shift_Del_p.RIGR1629fs|SCN5A_ENST00000450102.2_Frame_Shift_Del_p.RIGR1575fs|SCN5A_ENST00000449557.2_Frame_Shift_Del_p.RIGR1575fs|SCN5A_ENST00000423572.2_Frame_Shift_Del_p.RIGR1628fs|SCN5A_ENST00000443581.1_Frame_Shift_Del_p.RIGR1628fs	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1629					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.I1630I(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTCTGAGGATGCGGCCTATTCGGGCCAGGCG	0.592													13	116	---	---	---	---						-	38592977	GCGGCCTATTC	-	38592967	7	5	17	1	0	1	0	1	0	0	0	0	13975	1306	46	0	1158	0	SCN5A	3	38592967	Frame_Shift_Del	DEL	GCGGCCTATTC	TCGA-N6-A4VD-01A-11D-A28R-08		38592967	159429463	21	1141										
ALS2CL	259173	broad.mit.edu	37	chr3	46713390	46713390	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tcaccgggcgcgcgacaccaCgtagatgagaagtggcagca	14	12	1	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:46713390C>T	ENST00000318962.4	-	24	2751	c.2668G>A	c.(2668-2670)Gtg>Atg	p.V890M	ALS2CL_ENST00000415953.1_Missense_Mutation_p.V890M|ALS2CL_ENST00000383742.3_Missense_Mutation_p.V237M	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	890	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CGCGACACCACGTAGATGAGA	0.627													15	24					0	0	1	0	0	T	46713390	C	T	46713390	3	4	17	1	0	0	0	0	1	0	0	0	547	536	19	1	205	1	ALS2CL	3	46713390	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	8120423	46713390	151309040	22	1142										
ITIH3	3699	broad.mit.edu	37	chr3	52833799	52833799	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cccttctcagaatcctggaaGatatgcaagaggaagactat	9	9	1	4			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:52833799G>A	ENST00000449956.2	+	9	943	c.937G>A	c.(937-939)Gat>Aat	p.D313N	ITIH3_ENST00000465243.2_3'UTR|ITIH3_ENST00000416872.2_Missense_Mutation_p.D313N	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	313	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AATCCTGGAAGATATGCAAGA	0.537													5	15					0	0	1	0	0	A	52833799	G	A	52833799	3	1	17	1	0	0	0	0	1	0	0	0	7948	942	33	3	971	3	ITIH3	3	52833799	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	6120409	52833799	145188631	23	1143										
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			44	9					0	0	1	0	0	G	178952085	A	G	178952085	3	3	17	1	0	0	0	0	1	0	0	0	11960	217	8	4	3218	4	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	126118286	178952085	19070345	24	1144										
TBC1D1	23216	broad.mit.edu	37	chr4	38138875	38138875	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cggtcggccctgctgcagacGgtggaggagctgcggcggcg	20	12	0	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr4:38138875G>A	ENST00000261439.4	+	20	3781	c.3426G>A	c.(3424-3426)acG>acA	p.T1142T	TBC1D1_ENST00000407365.1_3'UTR|TBC1D1_ENST00000508802.1_Silent_p.T1133T	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1142						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TGCTGCAGACGGTGGAGGAGC	0.642													29	27					0	0	1	0	0	A	38138875	G	A	38138875	2	1	17	1	0	0	0	0	0	0	0	1	15653	1103	39	1		1	TBC1D1	4	38138875	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		38138875	153015401	25	1145										
FBXW7	0	broad.mit.edu	37	chr4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aaaccctaagagtggcatctCgagaaccgctaacaactctg	8	12	2	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr4:153247366C>T	ENST00000281708.4	-	10	2665	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	FBXW7_ENST00000603548.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000263981.5_Missense_Mutation_p.R399Q|FBXW7_ENST00000296555.5_Missense_Mutation_p.R361Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000393956.3_Missense_Mutation_p.R303Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	479					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R479Q(29)|p.R479L(5)|p.R399Q(3)|p.R479P(2)|p.R240L(1)|p.R361P(1)|p.R399P(1)|p.?(1)|p.R361Q(1)|p.R399L(1)|p.R240Q(1)|p.R240P(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								21	27					0	0	1	0	0	T	153247366	C	T	153247366	3	4	17	1	0	0	0	0	1	0	0	0	5801	884	31	1	699	1	FBXW7	4	153247366	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	115108491	153247366	37906910	26	1146										
DCP2	167227	broad.mit.edu	37	chr5	112312615	112312615	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	agccgggatgcactgttcctGctgtgggtcctcatcatgga	13	11	2	0	rs2416298		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:112312615G>A	ENST00000543319.1	+	0	137				DCP2_ENST00000504961.1_3'UTR|DCP2_ENST00000515408.1_De_novo_Start_InFrame|DCP2_ENST00000389063.2_De_novo_Start_InFrame			Q8IU60	DCP2_HUMAN	decapping mRNA 2						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		CACTGTTCCTGCTGTGGGTCC	0.682													52	86					0	0	1	0	0	A	112312615	G	A	112312615	1	1	17	1	0	0	0	0	0	0	0	0	4323	1334	46	3		3	DCP2	5	112312615	Translation_Start_Site	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		112312615	68602645	27	1147										
PCDHA2	0	broad.mit.edu	37	chr5	140176114	140176114	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	caaggtgtacgcgctgcagcCgctggaccacgaggaagtgg	16	11	0	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:140176114C>T	ENST00000526136.1	+	1	1565	c.1565C>T	c.(1564-1566)cCg>cTg	p.P522L	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.P522L|PCDHA2_ENST00000378132.1_Missense_Mutation_p.P522L|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCTGCAGCCGCTGGACCAC	0.687													149	114					0	0	1	0	0	T	140176114	C	T	140176114	3	4	17	1	0	0	0	0	1	0	0	0	11570	652	23	1	1567	1	PCDHA2	5	140176114	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	27863499	140176114	40739146	28	1148										
PCDHB5	0	broad.mit.edu	37	chr5	140515028	140515028	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtctgaacaatggagactgcGctagcaaaaacgccacagaa	10	10	1	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:140515028G>A	ENST00000231134.5	+	1	229	c.12G>A	c.(10-12)gcG>gcA	p.A4A		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		4					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGAGACTGCGCTAGCAAAAA	0.463													24	57					0	0	1	0	0	A	140515028	G	A	140515028	2	1	17	1	0	0	0	0	0	0	0	1	11591	1074	38	1		1	PCDHB5	5	140515028	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	338914	140515028	40400232	29	1149										
PDGFRB	5159	broad.mit.edu	37	chr5	149497300	149497300	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tgcacggcagtatagaggacGgagctggtgtccaggggaga	18	7	0	2	rs2229559		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:149497300G>A	ENST00000261799.4	-	22	3487	c.3018C>T	c.(3016-3018)tcC>tcT	p.S1006S		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	1006					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TATAGAGGACGGAGCTGGTGT	0.617			T	"ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"	"MPD, AML, CMML, CML"								24	47					0	0	1	0	0	A	149497300	G	A	149497300	2	1	17	1	0	0	0	0	0	0	0	1	11708	1103	39	1		1	PDGFRB	5	149497300	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	8982272	149497300	31417960	30	1150										
STK10	6793	broad.mit.edu	37	chr5	171509417	171509417	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cgcctggcctcctcccggcgGcgcacggcatggtcttgctc	13	18	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:171509417G>A	ENST00000176763.5	-	12	2245	c.1902C>T	c.(1900-1902)cgC>cgT	p.R634R		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	634							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTCCCGGCGGCGCACGGCAT	0.552													50	104					0	0	1	0	0	A	171509417	G	A	171509417	2	1	17	1	0	0	0	0	0	0	0	1	15341	1190	42	3		3	STK10	5	171509417	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	22012117	171509417	9405843	31	1151										
PRL	5617	broad.mit.edu	37	chr6	22290511	22290511	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tcttgcataccacgtacttcCgtgaccagatgatacagagg	9	11	1	4			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:22290511C>T	ENST00000306482.1	-	4	902	c.384G>A	c.(382-384)acG>acA	p.T128T	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	128					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					CACGTACTTCCGTGACCAGAT	0.463													29	40					0	0	1	0	0	T	22290511	C	T	22290511	2	4	17	1	0	0	0	0	0	0	0	1	12579	639	23	1		1	PRL	6	22290511	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		22290511	148824556	32	1152										
HIST1H2AL	8332	broad.mit.edu	37	chr6	27833147	27833147	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttcgtcatgtcgggacgcggCaagcagggaggcaaagctcg	16	10	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:27833147C>T	ENST00000357320.2	+	1	114	c.15C>T	c.(13-15)ggC>ggT	p.G5G		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	5					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						CGGGACGCGGCAAGCAGGGAG	0.587													45	76					0	0	1	0	0	T	27833147	C	T	27833147	2	4	17	1	0	0	0	0	0	0	0	1	7178	697	25	3		3	HIST1H2AL	6	27833147	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	5542636	27833147	143281920	33	1153										
GSTA3	2940	broad.mit.edu	37	chr6	52762720	52762720	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cagcccggctcagcttgttgCcaacaaggtagtcttgtcca	10	13	2	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:52762720C>A	ENST00000211122.3	-	6	514	c.449G>T	c.(448-450)gGc>gTc	p.G150V	GSTA3_ENST00000370968.1_Missense_Mutation_p.G100V	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	150	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	CAGCTTGTTGCCAACAAGGTA	0.517													58	66					1.13205e-32	1.21438e-32	1	1	0	A	52762720	C	A	52762720	3	1	17	1	0	0	0	0	1	0	0	0	6872	739	26	5	227	5	GSTA3	6	52762720	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	24929573	52762720	118352347	34	1154										
CCR6	1235	broad.mit.edu	37	chr6	167550589	167550589	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tgaaccgatcctgccagagcGaaaagctaattggctatacg	10	10	0	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:167550589G>A	ENST00000341935.5	+	3	1423	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	CCR6_ENST00000349984.4_Missense_Mutation_p.E291K|CCR6_ENST00000400926.2_Missense_Mutation_p.E291K	NM_031409.3	NP_113597.2	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	291					cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	14		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CTGCCAGAGCGAAAAGCTAAT	0.483													35	66					0	0	1	0	0	A	167550589	G	A	167550589	3	1	17	1	0	0	0	0	1	0	0	0	2967	1059	37	1	877	1	CCR6	6	167550589	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	114787869	167550589	3564478	35	1155										
CHST12	55501	broad.mit.edu	37	chr7	2473140	2473140	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cagcctgcccgcctcggcgcGcgaggccttccgcgctggcc	14	20	0	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:2473140G>A	ENST00000258711.6	+	2	1001	c.866G>A	c.(865-867)cGc>cAc	p.R289H		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	289					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		GCCTCGGCGCGCGAGGCCTTC	0.652													35	35					0	0	1	0	0	A	2473140	G	A	2473140	3	1	17	1	0	0	0	0	1	0	0	0	3422	1087	38	1	868	1	CHST12	7	2473140	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		2473140	156665523	36	1156										
HERPUD2	64224	broad.mit.edu	37	chr7	35674870	35674870	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cagtctagccagtctcgattGaagtcttcttcatttagtac	7	10	5	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:35674870G>T	ENST00000396081.1	-	6	1620	c.816C>A	c.(814-816)ttC>ttA	p.F272L	HERPUD2_ENST00000311350.3_Missense_Mutation_p.F272L|HERPUD2_ENST00000426180.1_5'UTR	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	272					response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						AGTCTCGATTGAAGTCTTCTT	0.438													37	46					3.62531e-18	3.85393e-18	1	1	0	T	35674870	G	T	35674870	3	4	17	1	0	0	0	0	1	0	0	0	7104	1281	45	2	416	2	HERPUD2	7	35674870	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	33201730	35674870	123463793	37	1157										
CD36	948	broad.mit.edu	37	chr7	80290415	80290415	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aaggaaaatgtaacccaggaCgctgaggacaacacagtctc	10	10	1	1	rs146796766		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:80290415C>T	ENST00000435819.1	+	8	1002	c.318C>T	c.(316-318)gaC>gaT	p.D106D	CD36_ENST00000447544.2_Silent_p.D106D|CD36_ENST00000394788.3_Silent_p.D106D|CD36_ENST00000309881.7_Silent_p.D106D|CD36_ENST00000534394.1_Silent_p.D30D|CD36_ENST00000432207.1_Silent_p.D106D|CD36_ENST00000538969.1_Silent_p.D106D|CD36_ENST00000544133.1_Silent_p.D106D|CD36_ENST00000433696.2_Silent_p.D106D			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	106	Required for interaction with thrombospondins, THBS1 and THBS2.				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						TAACCCAGGACGCTGAGGACA	0.408													18	43					0	0	1	0	0	T	80290415	C	T	80290415	2	4	17	1	0	0	0	0	0	0	0	1	3029	535	19	1		1	CD36	7	80290415	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	44615545	80290415	78848248	38	1158										
KIAA1324L	222223	broad.mit.edu	37	chr7	86542401	86542401	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cctggagggcaggggacacaCgatgaacccgactgttcaga	14	11	1	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:86542401C>T	ENST00000450689.2	-	14	2036	c.1851G>A	c.(1849-1851)tcG>tcA	p.S617S	KIAA1324L_ENST00000297222.6_Silent_p.S377S|KIAA1324L_ENST00000490995.1_5'UTR|KIAA1324L_ENST00000444627.1_Intron|KIAA1324L_ENST00000416314.1_Silent_p.S450S	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	617						integral to membrane		p.S377S(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					AGGGGACACACGATGAACCCG	0.522													14	25					0	0	1	0	0	T	86542401	C	T	86542401	2	4	17	1	0	0	0	0	0	0	0	1	8265	523	19	1		1	KIAA1324L	7	86542401	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	6251986	86542401	72596262	39	1159										
CALCR	799	broad.mit.edu	37	chr7	93065414	93065414	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttcaggtacatgtgggattcCgcctcatgggtttccctcat	10	11	3	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:93065414C>T	ENST00000359558.2	-	14	1400	c.1101G>A	c.(1099-1101)gcG>gcA	p.A367A	CALCR_ENST00000394441.1_Silent_p.A333A|CALCR_ENST00000421592.1_Silent_p.A349A|CALCR_ENST00000426151.1_Silent_p.A333A|CALCR_ENST00000360249.4_Silent_p.A349A	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	349					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGTGGGATTCCGCCTCATGGG	0.478													12	23					0	0	1	0	0	T	93065414	C	T	93065414	2	4	17	1	0	0	0	0	0	0	0	1	2597	639	23	1		1	CALCR	7	93065414	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	6523013	93065414	66073249	40	1160										
ZNF655	79027	broad.mit.edu	37	chr7	99171161	99171161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aaagaactccagtcagagagCacatctagttcaacatcaga	7	10	4	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:99171161C>T	ENST00000424881.1	+	4	1755	c.1535C>T	c.(1534-1536)gCa>gTa	p.A512V	ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000394163.2_Missense_Mutation_p.A477V|ZNF655_ENST00000252713.4_Missense_Mutation_p.A477V|ZNF655_ENST00000493277.1_Missense_Mutation_p.A512V	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	477					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AGTCAGAGAGCACATCTAGTT	0.393													34	50					0	0	1	0	0	T	99171161	C	T	99171161	3	4	17	1	0	0	0	0	1	0	0	0	18124	710	25	3	1967	3	ZNF655	7	99171161	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	6105747	99171161	59967502	41	1161										
FBXO24	26261	broad.mit.edu	37	chr7	100187923	100187923	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tctgtcgcagactcagtccgCgcctccaagatcagggttct	10	14	4	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:100187923C>T	ENST00000241071.6	+	3	587	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	FBXO24_ENST00000498195.1_3'UTR|FBXO24_ENST00000427939.2_Missense_Mutation_p.R127C|FBXO24_ENST00000468962.1_Missense_Mutation_p.R77C|FBXO24_ENST00000465843.1_Missense_Mutation_p.R89C|FBXO24_ENST00000360609.2_Missense_Mutation_p.R89C|PCOLCE-AS1_ENST00000442166.2_RNA	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	89						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ACTCAGTCCGCGCCTCCAAGA	0.602													22	22					0	0	1	0	0	T	100187923	C	T	100187923	3	4	17	1	0	0	0	0	1	0	0	0	5767	768	27	1	432	1	FBXO24	7	100187923	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	1016762	100187923	58950740	42	1162										
EXOC4	60412	broad.mit.edu	37	chr7	133692545	133692545	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttgttcttcagcagaatttgAccaacatcaccatgtcgcgg	8	11	3	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:133692545A>G	ENST00000253861.4	+	17	2673	c.2644A>G	c.(2644-2646)Acc>Gcc	p.T882A	EXOC4_ENST00000541309.1_Missense_Mutation_p.T170A|EXOC4_ENST00000545148.1_Missense_Mutation_p.T492A|EXOC4_ENST00000539845.1_Missense_Mutation_p.T781A	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	882					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GCAGAATTTGACCAACATCAC	0.473													14	26					0	0	1	0	0	G	133692545	A	G	133692545	3	3	17	1	0	0	0	0	1	0	0	0	5333	275	10	4	2719	4	EXOC4	7	133692545	Missense_Mutation	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	33504622	133692545	25446118	43	1163										
RP1L1	94137	broad.mit.edu	37	chr8	10467031	10467031	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gggccaggaaggccttctccGtcttcttcagtaacacggac	11	13	4	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:10467031G>A	ENST00000382483.3	-	4	4800	c.4577C>T	c.(4576-4578)aCg>aTg	p.T1526M		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1526					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGCCTTCTCCGTCTTCTTCAG	0.662													29	42					0	0	1	0	0	A	10467031	G	A	10467031	3	1	17	1	0	0	0	0	1	0	0	0	13584	1145	40	1	2629	1	RP1L1	8	10467031	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		10467031	135896991	44	1164										
NRG1	3084	broad.mit.edu	37	chr8	32505335	32505335	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ccatctcttgatgggcttccGgcagcagaagacatgccaga	11	12	1	4			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:32505335G>A	ENST00000520502.2	+	1	99	c.99G>A	c.(97-99)ccG>ccA	p.P33P	NRG1_ENST00000523079.1_Intron|NRG1_ENST00000521670.1_Intron|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000520407.1_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000287840.5_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000519301.1_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000341377.5_Intron	NM_013959.3	NP_039253.1	Q02297	NRG1_HUMAN	neuregulin 1	0					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ATGGGCTTCCGGCAGCAGAAG	0.622													18	34					0	0	1	0	0	A	32505335	G	A	32505335	2	1	17	1	0	0	0	0	0	0	0	1	10694	1103	39	1		1	NRG1	8	32505335	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	22038304	32505335	113858687	45	1165										
PLEKHA2	59339	broad.mit.edu	37	chr8	38775463	38775463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	caggaatgccttatgtggatCggcagaaccgaatctgtggg	14	8	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:38775463C>T	ENST00000420274.1	+	2	250	c.16C>T	c.(16-18)Cgg>Tgg	p.R6W	PLEKHA2_ENST00000388745.4_3'UTR|PLEKHA2_ENST00000521746.1_Missense_Mutation_p.R6W	NM_021623.1	NP_067636.1	Q9HB19	PKHA2_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	6					positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	13		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)			TTATGTGGATCGGCAGAACCG	0.562													24	25					0	0	1	0	0	T	38775463	C	T	38775463	3	4	17	1	0	0	0	0	1	0	0	0	12103	875	31	1	18	1	PLEKHA2	8	38775463	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	6270128	38775463	107588559	46	1166										
ZFHX4	79776	broad.mit.edu	37	chr8	77766792	77766792	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	atatttgaccccaacaatccGctgatgactggacaactgct	7	12	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:77766792G>A	ENST00000521891.2	+	10	8083	c.7635G>A	c.(7633-7635)ccG>ccA	p.P2545P	ZFHX4_ENST00000050961.6_Silent_p.P2500P|ZFHX4_ENST00000455469.2_Silent_p.P2500P|ZFHX4_ENST00000518282.1_Silent_p.P2519P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2500						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P2529P(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAACAATCCGCTGATGACTG	0.537										HNSCC(33;0.089)			46	84					0	0	1	0	0	A	77766792	G	A	77766792	2	1	17	1	0	0	0	0	0	0	0	1	17692	1074	38	1		1	ZFHX4	8	77766792	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	38991329	77766792	68597230	47	1167										
KCNS2	3788	broad.mit.edu	37	chr8	99441462	99441462	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	agttctcccacttttaccggCgccaaaagcaacttgagagt	8	12	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:99441462C>T	ENST00000287042.4	+	2	1605	c.1255C>T	c.(1255-1257)Cgc>Tgc	p.R419C	KCNS2_ENST00000521839.1_Missense_Mutation_p.R419C	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	419						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R419C(1)		autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CTTTTACCGGCGCCAAAAGCA	0.512													47	101					0	0	1	0	0	T	99441462	C	T	99441462	3	4	17	1	0	0	0	0	1	0	0	0	8132	768	27	1	1257	1	KCNS2	8	99441462	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	21674670	99441462	46922560	48	1168										
CSMD3	114788	broad.mit.edu	37	chr8	113254010	113254010	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tctttcaccaatattttagaAccagctatgaaaagaaataa	4	7	2	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:113254010A>G	ENST00000297405.5	-	66	10651	c.10407T>C	c.(10405-10407)ggT>ggC	p.G3469G	CSMD3_ENST00000343508.3_Silent_p.G3429G|CSMD3_ENST00000352409.3_Silent_p.G3399G|CSMD3_ENST00000455883.2_Silent_p.G3300G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3469						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATATTTTAGAACCAGCTATGA	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	47					0	0	1	0	0	G	113254010	A	G	113254010	2	3	17	1	0	0	0	0	0	0	0	1	3971	30	2	4		4	CSMD3	8	113254010	Silent	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	13812548	113254010	33110012	49	1169										
SLC28A3	64078	broad.mit.edu	37	chr9	86894919	86894919	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aggctgtcatgaagcaggccAcggtccccgcaatcagagct	12	13	2	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:86894919A>G	ENST00000376238.4	-	16	1848	c.1799T>C	c.(1798-1800)gTg>gCg	p.V600A	SLC28A3_ENST00000537648.1_Missense_Mutation_p.V531A|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	600					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GAAGCAGGCCACGGTCCCCGC	0.587													11	23					0	0	1	0	0	G	86894919	A	G	86894919	3	3	17	1	0	0	0	0	1	0	0	0	14587	159	6	4	288	4	SLC28A3	9	86894919	Missense_Mutation	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08		86894919	54318512	50	1170										
CEL	1056	broad.mit.edu	37	chr9	135946658	135946658	+	Frame_Shift_Del	DEL	C	C	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gcccacgggtgactccggggCcccccccgtgccgcccacgg							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:135946658delC	ENST00000372080.4	+	11	1794	c.1778delC	c.(1777-1779)gcfs	p.A593fs	CEL_ENST00000351304.7_Frame_Shift_Del_p.A524fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	590	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GACTCCGGGGCCCCCCCCGTG	0.816													2	4	---	---	---	---						-	135946658	C	-	135946658	7	5	17	1	0	1	0	1	0	0	0	0	3231	739	26	0	1820	0	CEL	9	135946658	Frame_Shift_Del	DEL	C	TCGA-N6-A4VD-01A-11D-A28R-08	49051739	135946658	5266773	51	1171										
NET1	10276	broad.mit.edu	37	chr10	5496339	5496341	+	In_Frame_Del	DEL	CTC	CTC	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aagacttcctccagcgatgtCtcgagtctcccttcagtcga							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:5496339_5496341delCTC	ENST00000355029.4	+	9	1022_1024	c.880_882delCTC	c.(880-882)del	p.L294del	NET1_ENST00000380359.3_In_Frame_Del_p.L240del|NET1_ENST00000542715.1_In_Frame_Del_p.L113del	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	294	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity	p.L240I(1)|p.L294I(1)		breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						CCAGCGATGTCTCGAGTCTCCCT	0.433													22	27	---	---	---	---						-	5496341	CTC	-	5496339	7	5	17	1	0	1	0	1	0	0	0	0	10384	913	32	0	1011	0	NET1	10	5496339	In_Frame_Del	DEL	CTC	TCGA-N6-A4VD-01A-11D-A28R-08		5496339	130038408	52	1172										
KIAA1217	56243	broad.mit.edu	37	chr10	24810839	24810839	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtgtgcgcagcatgacagacGtcctgaccatgctgcggagg	15	11	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:24810839G>A	ENST00000376451.2	+	7	1746	c.1486G>A	c.(1486-1488)Gtc>Atc	p.V496I	KIAA1217_ENST00000458595.1_Missense_Mutation_p.V778I|KIAA1217_ENST00000376454.3_Missense_Mutation_p.V813I|KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000376452.3_Missense_Mutation_p.V778I|KIAA1217_ENST00000396445.1_Missense_Mutation_p.V496I|KIAA1217_ENST00000396446.1_Missense_Mutation_p.V496I|KIAA1217_ENST00000376462.1_Missense_Mutation_p.V733I|KIAA1217_ENST00000307544.6_Missense_Mutation_p.V496I			Q5T5P2	SKT_HUMAN	KIAA1217	813					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CATGACAGACGTCCTGACCAT	0.632													29	35					0	0	1	0	0	A	24810839	G	A	24810839	3	1	17	1	0	0	0	0	1	0	0	0	8257	1145	40	1	2483	1	KIAA1217	10	24810839	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	19314500	24810839	110723908	53	1173										
PTEN	5728	broad.mit.edu	37	chr10	89692980	89692980	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	acaagaggccctagatttctAtggggaagtaaggaccagag	13	7	1	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:89692980A>G	ENST00000371953.3	+	5	1821	c.464A>G	c.(463-465)tAt>tGt	p.Y155C		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	155	Phosphatase tensin-type.		Y -> C (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.Y155C(7)|p.?(5)|p.R55fs*1(5)|p.Y27fs*1(2)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTAGATTTCTATGGGGAAGTA	0.373		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			42	3					0	0	1	0	0	G	89692980	A	G	89692980	3	3	17	1	0	0	0	0	1	0	0	0	12786	449	16	4	482	4	PTEN	10	89692980	Missense_Mutation	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	64882141	89692980	45841767	54	1174										
DMBT1	1755	broad.mit.edu	37	chr10	124389946	124389946	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	accgaatgaccattcactttCgaagtgacatcagtttccaa	6	11	2	2	rs143073434	by1000genomes	TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:124389946C>T	ENST00000338354.3	+	45	5684	c.5578C>T	c.(5578-5580)Cga>Tga	p.R1860*	DMBT1_ENST00000368955.3_Nonsense_Mutation_p.R1850*|DMBT1_ENST00000368909.3_Nonsense_Mutation_p.R1860*|DMBT1_ENST00000368956.2_Nonsense_Mutation_p.R1232*|DMBT1_ENST00000330163.4_Nonsense_Mutation_p.R1232*|DMBT1_ENST00000359586.6_Nonsense_Mutation_p.R580*|DMBT1_ENST00000344338.3_Nonsense_Mutation_p.R1850*			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1860	CUB 1.		R -> L (in dbSNP:rs7099177).		epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CATTCACTTTCGAAGTGACAT	0.428													42	8					0	0	1	0	0	T	124389946	C	T	124389946	4	4	17	1	0	0	0	0	0	1	0	0	4605	876	31	1	5756	1	DMBT1	10	124389946	Nonsense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	34696966	124389946	11144801	55	1175										
ADAM12	8038	broad.mit.edu	37	chr10	127724804	127724804	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtggaggggaggaagcactcGctgagttgactggggctgag	20	6	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:127724804G>A	ENST00000368679.4	-	21	2758	c.2449C>T	c.(2449-2451)Cga>Tga	p.R817*		NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	817					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding	p.R817*(2)		biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GGAAGCACTCGCTGAGTTGAC	0.597													31	44					0	0	1	0	0	A	127724804	G	A	127724804	4	1	17	1	0	0	0	0	0	1	0	0	235	1095	38	1	292	1	ADAM12	10	127724804	Nonsense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	3334858	127724804	7809943	56	1176										
OR52I2	143502	broad.mit.edu	37	chr11	4608812	4608812	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aattctcaaggcagtatttgGtctctcctcaaagactgctc	7	11	3	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:4608812G>A	ENST00000312614.4	+	1	792	c.770G>A	c.(769-771)gGt>gAt	p.G257D		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCAGTATTTGGTCTCTCCTCA	0.473													42	69					0	0	1	0	0	A	4608812	G	A	4608812	3	1	17	1	0	0	0	0	1	0	0	0	11168	1261	44	3	772	3	OR52I2	11	4608812	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		4608812	130397704	57	1177										
MRGPRX3	117195	broad.mit.edu	37	chr11	18159005	18159005	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	acattatatgttcgccgttaCgcctcatcaatatccgccat	5	13	2	0	rs141255495		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:18159005C>T	ENST00000396275.2	+	3	617	c.256C>T	c.(256-258)Cgc>Tgc	p.R86C		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	86						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTCGCCGTTACGCCTCATCAA	0.547													45	67					0	0	1	0	0	T	18159005	C	T	18159005	3	4	17	1	0	0	0	0	1	0	0	0	9816	536	19	1	258	1	MRGPRX3	11	18159005	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	13550193	18159005	116847511	58	1178										
DGKZ	8525	broad.mit.edu	37	chr11	46388900	46388900	+	Frame_Shift_Del	DEL	C	C	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ccctccgcccacccctggggCcccgtgcagcgagtcagagc							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:46388900delC	ENST00000454345.1	+	3	913	c.788delC	c.(787-789)gcfs	p.A263fs	DGKZ_ENST00000528615.1_Intron|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000395574.3_Frame_Shift_Del_p.A40fs|DGKZ_ENST00000525434.1_3'UTR|DGKZ_ENST00000532868.2_Frame_Shift_Del_p.A79fs|DGKZ_ENST00000318201.8_Frame_Shift_Del_p.A74fs|DGKZ_ENST00000421244.2_Frame_Shift_Del_p.A74fs|DGKZ_ENST00000456247.2_Frame_Shift_Del_p.A74fs|DGKZ_ENST00000343674.6_Frame_Shift_Del_p.A91fs|DGKZ_ENST00000527911.1_Frame_Shift_Del_p.A74fs	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	263					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		ACCCCTGGGGCCCCGTGCAGC	0.662													21	29	---	---	---	---						-	46388900	C	-	46388900	7	5	17	1	0	1	0	1	0	0	0	0	4502	739	26	0	1238	0	DGKZ	11	46388900	Frame_Shift_Del	DEL	C	TCGA-N6-A4VD-01A-11D-A28R-08	28229895	46388900	88617616	59	1179										
OR4C6	219432	broad.mit.edu	37	chr11	55432696	55432696	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cttctgggtctcacagagaaCctggagctgtggaaaatatt	11	8	2	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:55432696C>G	ENST00000314259.3	+	1	83	c.54C>G	c.(52-54)aaC>aaG	p.N18K		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TCACAGAGAACCTGGAGCTGT	0.383													33	50					0	0	1	0	0	G	55432696	C	G	55432696	3	3	17	1	0	0	0	0	1	0	0	0	11099	506	18	5	56	5	OR4C6	11	55432696	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	9043796	55432696	79573820	60	1180										
CDC42EP2	10435	broad.mit.edu	37	chr11	65088659	65088659	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cgtgtgtgggcgggagctccCggacggcccatcccctctgc	15	16	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:65088659C>T	ENST00000544348.1	+	2	896	c.290C>T	c.(289-291)cCg>cTg	p.P97L	CDC42EP2_ENST00000533419.1_Missense_Mutation_p.P97L|CDC42EP2_ENST00000279249.2_Missense_Mutation_p.P97L			O14613	BORG1_HUMAN	CDC42 effector protein (Rho GTPase binding) 2	97					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity			lung(1)	1						CGGGAGCTCCCGGACGGCCCA	0.682													29	44					0	0	1	0	0	T	65088659	C	T	65088659	3	4	17	1	0	0	0	0	1	0	0	0	3098	652	23	1	292	1	CDC42EP2	11	65088659	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	9655963	65088659	69917857	61	1181										
KIRREL3	84623	broad.mit.edu	37	chr11	126306737	126306737	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	agccggatgatctcagtgtcGgagccgaagctgttccaggc	14	11	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:126306737G>A	ENST00000525144.2	-	12	1770	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	KIRREL3_ENST00000416561.2_5'UTR|KIRREL3_ENST00000525704.2_Silent_p.S507S|KIRREL3_ENST00000529097.2_Silent_p.S507S	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	507	Ig-like C2-type 5.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding	p.S466S(1)		central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TCTCAGTGTCGGAGCCGAAGC	0.607													16	22					0	0	1	0	0	A	126306737	G	A	126306737	2	1	17	1	0	0	0	0	0	0	0	1	8368	1103	39	1		1	KIRREL3	11	126306737	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	61218078	126306737	8699779	62	1182										
GLB1L3	112937	broad.mit.edu	37	chr11	134179612	134179612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ccaactttggtttcatgaacGgggccacatatttcgggaag	11	9	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:134179612G>A	ENST00000431683.2	+	11	1054	c.1054G>A	c.(1054-1056)Ggg>Agg	p.G352R		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	352					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTTCATGAACGGGGCCACATA	0.483													3	12					0	0	1	0	0	A	134179612	G	A	134179612	3	1	17	1	0	0	0	0	1	0	0	0	6471	1116	39	1	1096	1	GLB1L3	11	134179612	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	7872875	134179612	826904	63	1183										
DCP1B	196513	broad.mit.edu	37	chr12	2062350	2062351	+	In_Frame_Ins	INS	-	-	TGG													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gctgctgctgctgctgctgcINStggtggagagtctgcggagg							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:2062350_2062351insTGG	ENST00000280665.6	-	7	834_835	c.755_756insCCA	c.(754-756)cca>cCCAca	p.252_253insT	DCP1B_ENST00000540622.1_In_Frame_Ins_p.126_127insT|DCP1B_ENST00000397173.4_In_Frame_Ins_p.150_151insT|DCP1B_ENST00000541700.1_5'UTR	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAGT	0.55													22	34	---	---	---	---						TGG	2062351	-	TGG	2062350	7	5	17	1	0	1	1	0	0	0	0	0	4322	796	28	0	1109	0	DCP1B	12	2062350	In_Frame_Ins	INS	-	TCGA-N6-A4VD-01A-11D-A28R-08		2062350	131789545	64	1184										
ADCY6	112	broad.mit.edu	37	chr12	49169177	49169177	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tgctgcgggcatcgatggcaCggctcaggaactcatccacc	12	14	2	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:49169177C>T	ENST00000307885.4	-	10	2583	c.1889G>A	c.(1888-1890)cGt>cAt	p.R630H	ADCY6_ENST00000550422.1_Missense_Mutation_p.R630H|ADCY6_ENST00000357869.3_Missense_Mutation_p.R630H|ADCY6_ENST00000552090.1_5'UTR	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	630					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						ATCGATGGCACGGCTCAGGAA	0.587													35	37					0	0	1	0	0	T	49169177	C	T	49169177	3	4	17	1	0	0	0	0	1	0	0	0	297	536	19	1	1665	1	ADCY6	12	49169177	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	47106827	49169177	84682718	65	1185										
FGD6	55785	broad.mit.edu	37	chr12	95531317	95531317	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cctcaaattctctaacaacaGcagcaaaacctggatttttc	4	12	2	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:95531317G>A	ENST00000343958.4	-	7	3198	c.2975C>T	c.(2974-2976)gCt>gTt	p.A992V	FGD6_ENST00000546711.1_Missense_Mutation_p.A992V|FGD6_ENST00000549499.1_Missense_Mutation_p.A992V	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	992	DH.			A -> T (in Ref. 2; AAH13319).	actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TCTAACAACAGCAGCAAAACC	0.328													21	33					0	0	1	0	0	A	95531317	G	A	95531317	3	1	17	1	0	0	0	0	1	0	0	0	5869	971	34	3	1377	3	FGD6	12	95531317	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	46362140	95531317	38320578	66	1186										
CDX2	1045	broad.mit.edu	37	chr13	28537414	28537414	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ggctgtggtggcggcggaggCggctgtggtggctgctgctg	23	8	0	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr13:28537414C>T	ENST00000381020.7	-	3	2912	c.780G>A	c.(778-780)ccG>ccA	p.P260P	CDX2_ENST00000548877.1_5'UTR	NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	260	Poly-Pro.				organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		GCGGCGGAGGCGGCTGTGGTG	0.567			T	ETV6	AML								25	23					0	0	1	0	0	T	28537414	C	T	28537414	2	4	17	1	0	0	0	0	0	0	0	1	3205	755	27	1		1	CDX2	13	28537414	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		28537414	86632464	67	1187										
FLT1	2321	broad.mit.edu	37	chr13	28896990	28896990	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gccggagctcgcaaagctttCgctgctggtgacgctatcta	12	12	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr13:28896990C>T	ENST00000282397.4	-	21	3141	c.2890G>A	c.(2890-2892)Gaa>Aaa	p.E964K	FLT1_ENST00000540678.1_Missense_Mutation_p.E182K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	964	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCAAAGCTTTCGCTGCTGGTG	0.478													40	75					0	0	1	0	0	T	28896990	C	T	28896990	3	4	17	1	0	0	0	0	1	0	0	0	5973	893	31	1	1166	1	FLT1	13	28896990	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	359576	28896990	86272888	68	1188										
SMOC1	64093	broad.mit.edu	37	chr14	70346406	70346406	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ggctggcaccatgctgcccgCgcgctgcgcccgcctgctca	13	19	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr14:70346406C>A	ENST00000381280.4	+	1	264	c.11C>A	c.(10-12)gCg>gAg	p.A4E	SMOC1_ENST00000555917.1_Intron|SMOC1_ENST00000361956.3_Missense_Mutation_p.A4E	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	4					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATGCTGCCCGCGCGCTGCGCC	0.751													6	3					3.59834e-05	3.66038e-05	1	1	0	A	70346406	C	A	70346406	3	1	17	1	0	0	0	0	1	0	0	0	14854	768	27	5	13	5	SMOC1	14	70346406	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		70346406	37003134	69	1189										
BCL11B	64919	broad.mit.edu	37	chr14	99641543	99641544	+	In_Frame_Ins	INS	-	-	CTC													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ctctcgttctccagtagcagINSctcctcctcctcctcctcct							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr14:99641543_99641544insCTC	ENST00000345514.2	-	3	1682_1683	c.1416_1417insGAG	c.(1414-1419)gatgct>gaGAGtgct	p.472_472D>ES	BCL11B_ENST00000443726.2_In_Frame_Ins_p.349_349D>ES|BCL11B_ENST00000357195.3_In_Frame_Ins_p.543_543D>ES	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	543						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TCCAGTAGCAGctcctcctcct	0.698			T	TLX3	T-ALL								3	5	---	---	---	---						CTC	99641544	-	CTC	99641543	7	5	17	1	0	1	1	0	0	0	0	0	1362	962	34	0	1058	0	BCL11B	14	99641543	In_Frame_Ins	INS	-	TCGA-N6-A4VD-01A-11D-A28R-08	29295137	99641543	7707997	70	1190										
TMEM62	80021	broad.mit.edu	37	chr15	43441229	43441229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ttatttttcattggttagttCggctatagcttatttgtgtg	9	4	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr15:43441229C>T	ENST00000260403.2	+	7	1025	c.746C>T	c.(745-747)tCg>tTg	p.S249L		NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	249						integral to membrane				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		TTGGTTAGTTCGGCTATAGCT	0.408													27	30					0	0	1	0	0	T	43441229	C	T	43441229	3	4	17	1	0	0	0	0	1	0	0	0	16248	893	31	1	772	1	TMEM62	15	43441229	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		43441229	59090163	71	1191										
BFAR	51283	broad.mit.edu	37	chr16	14743799	14743799	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cttgggcatctctttacaggGaaaggtttttatctgaacga	10	7	2	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:14743799G>A	ENST00000261658.2	+	4	884	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K	BFAR_ENST00000563971.1_Intron|BFAR_ENST00000426842.2_Missense_Mutation_p.E75K	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	203	SAM.				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						TCTTTACAGGGAAAGGTTTTT	0.493													17	33					0	0	1	0	0	A	14743799	G	A	14743799	3	1	17	1	0	0	0	0	1	0	0	0	1413	1175	41	3	617	3	BFAR	16	14743799	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		14743799	75610954	72	1192										
ACSF3	197322	broad.mit.edu	37	chr16	89167646	89167646	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	agaggaaccggcagaggtccCggtcccagagcagggatgga	17	10	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:89167646C>T	ENST00000317447.4	+	3	934	c.557C>T	c.(556-558)cCg>cTg	p.P186L	ACSF3_ENST00000378345.4_Intron|ACSF3_ENST00000406948.3_Missense_Mutation_p.P186L	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	186					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		GCAGAGGTCCCGGTCCCAGAG	0.642													9	7					0	0	1	0	0	T	89167646	C	T	89167646	3	4	17	1	0	0	0	0	1	0	0	0	176	652	23	1	559	1	ACSF3	16	89167646	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	74423847	89167646	1187107	73	1193										
SPIRE2	84501	broad.mit.edu	37	chr16	89895123	89895123	+	Frame_Shift_Del	DEL	G	G	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cgcgggctgcggggctcgccGggccggcgcctgcgggatac							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:89895123delG	ENST00000378247.3	+	1	208	c.165delG	c.(163-165)ccfs	p.P55fs	SPIRE2_ENST00000564878.1_Intron|SPIRE2_ENST00000563972.1_Frame_Shift_Del_p.P55fs|SPIRE2_ENST00000393062.2_Frame_Shift_Del_p.P55fs	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	55	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GGGGCTCGCCGGGCCGGCGCC	0.781													2	4	---	---	---	---						-	89895123	G	-	89895123	7	5	17	1	0	1	0	1	0	0	0	0	15127	1103	39	0	167	0	SPIRE2	16	89895123	Frame_Shift_Del	DEL	G	TCGA-N6-A4VD-01A-11D-A28R-08	727477	89895123	459630	74	1194										
SPIRE2	84501	broad.mit.edu	37	chr16	89922602	89922602	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tggaggagatcaagcaggagCggaggctgcgcccggtgcgg	20	9	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:89922602C>A	ENST00000378247.3	+	7	1103	c.1060C>A	c.(1060-1062)Cgg>Agg	p.R354R	SPIRE2_ENST00000393062.2_Silent_p.R354R	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	354	WH2 3.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CAAGCAGGAGCGGAGGCTGCG	0.682													7	11					1	1	1	1	0	A	89922602	C	A	89922602	2	1	17	1	0	0	0	0	0	0	0	1	15127	759	27	5		5	SPIRE2	16	89922602	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	27479	89922602	432151	75	1195										
MPRIP	23164	broad.mit.edu	37	chr17	17078626	17078626	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ggagctgaacaaccgcctggCtgcagagatcacacggttgc	13	12	1	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:17078626C>T	ENST00000395811.5	+	19	2698	c.2609C>T	c.(2608-2610)gCt>gTt	p.A870V	MPRIP_ENST00000395804.3_Missense_Mutation_p.A870V|MPRIP_ENST00000341712.4_Missense_Mutation_p.A870V|MPRIP_ENST00000444976.1_Missense_Mutation_p.A832V|RP11-45M22.3_ENST00000584203.1_RNA	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	870	Interaction with PPP1R12A.					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						AACCGCCTGGCTGCAGAGATC	0.622													7	46					0	0	1	0	0	T	17078626	C	T	17078626	3	4	17	1	0	0	0	0	1	0	0	0	9791	797	28	3	2683	3	MPRIP	17	17078626	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		17078626	64116584	76	1196										
RHBDL3	162494	broad.mit.edu	37	chr17	30611720	30611720	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	acattagcacaggcaagttcCggagtcttctggagagccac	11	11	2	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:30611720C>T	ENST00000269051.4	+	3	192	c.178C>T	c.(178-180)Cgg>Tgg	p.R60W	RHBDL3_ENST00000536287.1_Intron|RHBDL3_ENST00000538145.1_Missense_Mutation_p.R52W	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	60	EF-hand 1.				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				AGGCAAGTTCCGGAGTCTTCT	0.592													21	31					0	0	1	0	0	T	30611720	C	T	30611720	3	4	17	1	0	0	0	0	1	0	0	0	13372	643	23	1	188	1	RHBDL3	17	30611720	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	13533094	30611720	50583490	77	1197										
STAT3	6774	broad.mit.edu	37	chr17	40481653	40481653	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtgtttgtgcccagaatgttAaatttccgggatctgaatca	10	7	2	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:40481653A>C	ENST00000264657.5	-	13	1464	c.1152T>G	c.(1150-1152)ttT>ttG	p.F384L	STAT3_ENST00000389272.3_Missense_Mutation_p.F286L|STAT3_ENST00000585517.1_Missense_Mutation_p.F384L|STAT3_ENST00000404395.3_Missense_Mutation_p.F384L|STAT3_ENST00000588969.1_Missense_Mutation_p.F384L	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	384			F -> L (in AD-HIES).|F -> S (in AD-HIES).		cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CCAGAATGTTAAATTTCCGGG	0.458									Hyperimmunoglobulin E Recurrent Infection Syndrome				36	39					0	0	1	0	0	C	40481653	A	C	40481653	3	2	17	1	0	0	0	0	1	0	0	0	15321	359	13	4	1208	4	STAT3	17	40481653	Missense_Mutation	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	9869933	40481653	40713557	78	1198										
NSF	4905	broad.mit.edu	37	chr17	44782178	44782178	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gcagaaagcctgcaagtgacGagaggagacttccttgcttc	12	10	0	4			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:44782178G>A	ENST00000398238.4	+	13	1535	c.1428G>A	c.(1426-1428)acG>acA	p.T476T	NSF_ENST00000225282.8_Silent_p.T382T|NSF_ENST00000575068.1_Silent_p.T471T	NM_006178.3	NP_006169.2	P46459	NSF_HUMAN	N-ethylmaleimide-sensitive factor	476			T -> M (in dbSNP:rs155733).		protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			kidney(2)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		TGCAAGTGACGAGAGGAGACT	0.383													21	34					0	0	1	0	0	A	44782178	G	A	44782178	2	1	17	1	0	0	0	0	0	0	0	1	10718	1045	37	1		1	NSF	17	44782178	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	4300525	44782178	36413032	79	1199										
PGS1	9489	broad.mit.edu	37	chr17	76395556	76395556	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ctcatccctgagcgcttcaaCgagaccatcggcctccagca	8	17	2	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:76395556C>T	ENST00000262764.6	+	5	665	c.639C>T	c.(637-639)aaC>aaT	p.N213N	PGS1_ENST00000588281.1_3'UTR|PGS1_ENST00000329897.7_Silent_p.N78N	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	213					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			AGCGCTTCAACGAGACCATCG	0.607													38	60					0	0	1	0	0	T	76395556	C	T	76395556	2	4	17	1	0	0	0	0	0	0	0	1	11855	535	19	1		1	PGS1	17	76395556	Silent	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	31613378	76395556	4799654	80	1200										
CD226	10666	broad.mit.edu	37	chr18	67563152	67563152	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aagttaagaggtcgatctgaCggggctggatcttttcccac	12	9	2	2	rs79158855	byFrequency	TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr18:67563152C>T	ENST00000280200.4	-	4	780	c.512G>A	c.(511-513)cGt>cAt	p.R171H	CD226_ENST00000577287.1_Missense_Mutation_p.R16H|CD226_ENST00000581982.1_Missense_Mutation_p.R16H|CD226_ENST00000582621.1_Missense_Mutation_p.R171H	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	171	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				GTCGATCTGACGGGGCTGGAT	0.512													26	28					0	0	1	0	0	T	67563152	C	T	67563152	3	4	17	1	0	0	0	0	1	0	0	0	3008	536	19	1	514	1	CD226	18	67563152	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08		67563152	10514096	81	1201										
ADAT3	113179	broad.mit.edu	37	chr19	1912242	1912242	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tgctggcctacgccgcgcccGtcctggacaagcgccagacc	12	18	0	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:1912242G>A	ENST00000329478.2	+	2	416	c.196G>A	c.(196-198)Gtc>Atc	p.V66I	ADAT3_ENST00000602400.1_Missense_Mutation_p.V50I|SCAMP4_ENST00000414057.2_Intron|SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000316097.8_Intron			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	50					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCGCGCCCGTCCTGGACAA	0.736													8	7					0	0	1	0	0	A	1912242	G	A	1912242	3	1	17	1	0	0	0	0	1	0	0	0	285	1145	40	1	150	1	ADAT3	19	1912242	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		1912242	57216741	82	1202										
OCEL1	79629	broad.mit.edu	37	chr19	17338751	17338751	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ctccagcacgaggtggggtgTgcacaggcaaagctcaggca	15	11	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:17338751T>C	ENST00000215061.4	+	4	599	c.555T>C	c.(553-555)tgT>tgC	p.C185C	OCEL1_ENST00000601576.1_3'UTR|OCEL1_ENST00000597836.1_Silent_p.C129C|OCEL1_ENST00000601529.1_Intron	NM_024578.1	NP_078854.1	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	185										central_nervous_system(2)|endometrium(2)|kidney(1)|lung(2)	7						AGGTGGGGTGTGCACAGGCAA	0.637													25	46					0	0	1	0	0	C	17338751	T	C	17338751	2	2	17	1	0	0	0	0	0	0	0	1	10863	1702	59	4		4	OCEL1	19	17338751	Silent	SNP	T	TCGA-N6-A4VD-01A-11D-A28R-08	15426509	17338751	41790232	83	1203										
AXL	558	broad.mit.edu	37	chr19	41743930	41743930	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ccctcacctcgcaagcatccGtgcccccccatcagcttcgg	7	21	2	0	rs141302305		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:41743930G>A	ENST00000301178.4	+	7	1055	c.865G>A	c.(865-867)Gtg>Atg	p.V289M	AXL_ENST00000359092.3_Missense_Mutation_p.V289M|AXL_ENST00000593513.1_Missense_Mutation_p.V21M	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	289	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V289M(2)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GCAAGCATCCGTGCCCCCCCA	0.647													43	67					0	0	1	0	0	A	41743930	G	A	41743930	3	1	17	1	0	0	0	0	1	0	0	0	1236	1145	40	1	891	1	AXL	19	41743930	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	24405179	41743930	17385053	84	1204										
CIC	23152	broad.mit.edu	37	chr19	42794634	42794634	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gcagcacagcgggccccctaCggcccccaccccctggggct	12	21	0	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:42794634C>T	ENST00000572681.2	+	11	4509	c.4441C>T	c.(4441-4443)Cgg>Tgg	p.R1481W	CIC_ENST00000160740.3_Missense_Mutation_p.R572W|CIC_ENST00000575354.2_Missense_Mutation_p.R572W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGGCCCCCTACGGCCCCCACC	0.672			"Mis, F, S"		oligodendroglioma								35	50					0	0	1	0	0	T	42794634	C	T	42794634	3	4	17	1	0	0	0	0	1	0	0	0	3446	527	19	1	1752	1	CIC	19	42794634	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	1050704	42794634	16334349	85	1205										
PPP2R1A	5518	broad.mit.edu	37	chr19	52716212	52716212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cctctcctctccctaggactCggtgcggctgctggcggtgg	14	15	2	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:52716212C>T	ENST00000322088.6	+	6	714	c.656C>T	c.(655-657)tCg>tTg	p.S219L	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S164L|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.S40L	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	219	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CCCTAGGACTCGGTGCGGCTG	0.647			Mis		clear cell ovarian carcinoma								22	22					0	0	1	0	0	T	52716212	C	T	52716212	3	4	17	1	0	0	0	0	1	0	0	0	12430	893	31	1	678	1	PPP2R1A	19	52716212	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	9921578	52716212	6412771	86	1206										
EPS8L1	54869	broad.mit.edu	37	chr19	55593930	55593930	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	acgtcactccacgtgaaaacGagctctggacctcgctgggg	12	13	2	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:55593930G>A	ENST00000201647.6	+	12	1230	c.1174G>A	c.(1174-1176)Gag>Aag	p.E392K	EPS8L1_ENST00000586329.1_Missense_Mutation_p.E374K|EPS8L1_ENST00000540810.1_Missense_Mutation_p.E328K|EPS8L1_ENST00000592824.1_3'UTR|EPS8L1_ENST00000245618.5_Missense_Mutation_p.E265K|EPS8L1_ENST00000588359.1_Missense_Mutation_p.E46K	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	392						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACGTGAAAACGAGCTCTGGAC	0.697													6	10					0	0	1	0	0	A	55593930	G	A	55593930	3	1	17	1	0	0	0	0	1	0	0	0	5223	1059	37	1	1268	1	EPS8L1	19	55593930	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	2877718	55593930	3535053	87	1207										
NLRP5	126206	broad.mit.edu	37	chr19	56569658	56569658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gtgaggcactctccttggccCtttcctgcaaccggcatctg	10	15	2	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:56569658C>T	ENST00000390649.3	+	14	3352	c.3352C>T	c.(3352-3354)Ctt>Ttt	p.L1118F		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1118						mitochondrion|nucleolus	ATP binding	p.L1118I(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTCCTTGGCCCTTTCCTGCAA	0.517													23	32					0	0	1	0	0	T	56569658	C	T	56569658	3	4	17	1	0	0	0	0	1	0	0	0	10526	681	24	3	3406	3	NLRP5	19	56569658	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	975728	56569658	2559325	88	1208										
CDH26	60437	broad.mit.edu	37	chr20	58569315	58569315	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cccatacaaggcttcccaccGcagactgctacagggaccct	8	17	0	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr20:58569315G>T	ENST00000348616.4	+	11	1737	c.1437G>T	c.(1435-1437)ccG>ccT	p.P479P	CDH26_ENST00000244047.5_Silent_p.P479P|CDH26_ENST00000497614.1_3'UTR	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	479	Cadherin 4.		P -> L (in dbSNP:rs6071067).		homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P479P(2)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GCTTCCCACCGCAGACTGCTA	0.517													25	34					9.04412e-07	9.28005e-07	1	1	0	T	58569315	G	T	58569315	2	4	17	1	0	0	0	0	0	0	0	1	3132	1074	38	5		5	CDH26	20	58569315	Silent	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		58569315	4456205	89	1209										
PLXNB2	23654	broad.mit.edu	37	chr22	50728775	50728775	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	actggctggcctcgatgggcGgcgtgcacttcttgttgtcc	14	12	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr22:50728775G>A	ENST00000449103.1	-	3	379	c.239C>T	c.(238-240)cCg>cTg	p.P80L	PLXNB2_ENST00000359337.4_Missense_Mutation_p.P80L			O15031	PLXB2_HUMAN	plexin B2	80	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity	p.P123L(1)		breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGATGGGCGGCGTGCACTT	0.652													20	6					0	0	1	0	0	A	50728775	G	A	50728775	3	1	17	1	0	0	0	0	1	0	0	0	12171	1116	39	1	5417	1	PLXNB2	22	50728775	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		50728775	575791	90	1210										
MAGEB6	158809	broad.mit.edu	37	chrX	26212339	26212339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tttcaggctcaaaatatgatGtggctgccaacggccaagat	10	9	2	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:26212339G>A	ENST00000379034.1	+	2	525	c.376G>A	c.(376-378)Gtg>Atg	p.V126M		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	126	Ser-rich.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AAAATATGATGTGGCTGCCAA	0.557													48	71					0	0	1	0	0	A	26212339	G	A	26212339	3	1	17	1	0	0	0	0	1	0	0	0	9228	1377	48	3	378	3	MAGEB6	23	26212339	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08		26212339	129058221	91	1211										
TAB3	257397	broad.mit.edu	37	chrX	30872877	30872877	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gctgtggagagctgaagggtGaaggacattgagaaggaggt	19	3	0	4			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:30872877G>A	ENST00000378933.1	-	3	1082	c.905C>T	c.(904-906)tCa>tTa	p.S302L	TAB3_ENST00000288422.2_Missense_Mutation_p.S302L|TAB3_ENST00000378932.2_Missense_Mutation_p.S302L|TAB3_ENST00000378930.3_Missense_Mutation_p.S302L	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	302	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						GCTGAAGGGTGAAGGACATTG	0.488													21	18					0	0	1	0	0	A	30872877	G	A	30872877	3	1	17	1	0	0	0	0	1	0	0	0	15553	1294	45	3	1257	3	TAB3	23	30872877	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	4660538	30872877	124397683	92	1212										
SUV39H1	6839	broad.mit.edu	37	chrX	48558921	48558921	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cccgggggcgtcactgcacaAgtttgcctacaatgaccagg	12	13	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:48558921A>C	ENST00000376687.3	+	3	795	c.605A>C	c.(604-606)aAg>aCg	p.K202T	SUV39H1_ENST00000337852.6_Missense_Mutation_p.K213T|SUV39H1_ENST00000453214.2_Intron|AF196970.3_ENST00000416061.1_RNA	NM_003173.2	NP_003164.1	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1 (Drosophila)	202	Pre-SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						TCACTGCACAAGTTTGCCTAC	0.652													22	46					0	0	1	0	0	C	48558921	A	C	48558921	3	2	17	1	0	0	0	0	1	0	0	0	15467	72	3	4	615	4	SUV39H1	23	48558921	Missense_Mutation	SNP	A	TCGA-N6-A4VD-01A-11D-A28R-08	17686044	48558921	106711639	93	1213										
SLC35A2	7355	broad.mit.edu	37	chrX	48762195	48762195	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gaggtagacagcaccaatgaCgagtccagcgccaagggcaa	13	11	0	2			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:48762195C>T	ENST00000376521.1	-	4	1312	c.991G>A	c.(991-993)Gtc>Atc	p.V331I	SLC35A2_ENST00000413561.2_Missense_Mutation_p.V270I|SLC35A2_ENST00000247138.5_Missense_Mutation_p.V331I|SLC35A2_ENST00000452555.2_Missense_Mutation_p.V359I|SLC35A2_ENST00000376515.3_Intron|SLC35A2_ENST00000445167.2_Intron|SLC35A2_ENST00000376529.3_Intron	NM_001042498.2	NP_001035963.1	P78381	S35A2_HUMAN	solute carrier family 35 (UDP-galactose transporter), member A2	331					galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(2)	15						GCACCAATGACGAGTCCAGCG	0.612													10	20					0	0	1	0	0	T	48762195	C	T	48762195	3	4	17	1	0	0	0	0	1	0	0	0	14625	536	19	1	363	1	SLC35A2	23	48762195	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	203274	48762195	106508365	94	1214										
RRAGB	10325	broad.mit.edu	37	chrX	55757849	55757849	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gccaacgggacaacatcttcCgaaatgtggaggttctgatt	11	9	2	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:55757849C>T	ENST00000374941.4	+	5	935	c.346C>T	c.(346-348)Cga>Tga	p.R116*	RRAGB_ENST00000474757.1_3'UTR|RRAGB_ENST00000262850.7_Nonsense_Mutation_p.R144*	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	144					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						CAACATCTTCCGAAATGTGGA	0.403													7	13					0	0	1	0	0	T	55757849	C	T	55757849	4	4	17	1	0	0	0	0	0	1	0	0	13724	644	23	1	452	1	RRAGB	23	55757849	Nonsense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	6995654	55757849	99512711	95	1215										
SLC16A2	6567	broad.mit.edu	37	chrX	73744511	73744511	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	aagcaagagaggtgtccgcaCcctgcaccagcgctttctgg	12	13	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:73744511C>A	ENST00000276033.5	+	3	1281	c.1115C>A	c.(1114-1116)aCc>aAc	p.T372N	SLC16A2_ENST00000587091.1_Missense_Mutation_p.T298N			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	298						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	GGTGTCCGCACCCTGCACCAG	0.572													39	47					2.91434e-09	3.04329e-09	1	1	0	A	73744511	C	A	73744511	3	1	17	1	0	0	0	0	1	0	0	0	14462	507	18	5	1125	5	SLC16A2	23	73744511	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	17986662	73744511	81526049	96	1216										
CYLC1	1538	broad.mit.edu	37	chrX	83128836	83128836	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cagagtctactgatactgaaTcaggagatgcaaaggatgca	11	7	2	4			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:83128836T>A	ENST00000329312.4	+	4	1157	c.1120T>A	c.(1120-1122)Tca>Aca	p.S374T		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	374					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TGATACTGAATCAGGAGATGC	0.323													15	14					0	0	1	0	0	A	83128836	T	A	83128836	3	1	17	1	0	0	0	0	1	0	0	0	4164	1435	50	4	1134	4	CYLC1	23	83128836	Missense_Mutation	SNP	T	TCGA-N6-A4VD-01A-11D-A28R-08	9384325	83128836	72141724	97	1217										
CHM	1121	broad.mit.edu	37	chrX	85218875	85218875	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cagcaccatttacttctagcGcattctctggatcgctgctt	7	13	2	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:85218875G>A	ENST00000357749.2	-	5	526	c.497C>T	c.(496-498)gCg>gTg	p.A166V	CHM_ENST00000537751.1_Missense_Mutation_p.A18V|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	166					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity	p.A166V(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TACTTCTAGCGCATTCTCTGG	0.443													30	49					0	0	1	0	0	A	85218875	G	A	85218875	3	1	17	1	0	0	0	0	1	0	0	0	3372	1087	38	1	1508	1	CHM	23	85218875	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	2090039	85218875	70051685	98	1218										
RHOXF1	158800	broad.mit.edu	37	chrX	119249405	119249405	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	catcagggtattgagtgtgtCggaaaacactttccagctcc	10	10	1	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:119249405C>T	ENST00000217999.2	-	1	442	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	123					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						TTGAGTGTGTCGGAAAACACT	0.577													37	51					0	0	1	0	0	T	119249405	C	T	119249405	3	4	17	1	0	0	0	0	1	0	0	0	13396	884	31	1	198	1	RHOXF1	23	119249405	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	34030530	119249405	36021155	99	1219										
BCORL1	63035	broad.mit.edu	37	chrX	129149592	129149592	+	Frame_Shift_Del	DEL	G	G	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	ggggacattcgaatgaatcaGgggcctgaggaatcagagag							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:129149592delG	ENST00000540052.1	+	3	2888	c.2844delG	c.(2842-2844)cafs	p.Q948fs	BCORL1_ENST00000218147.7_Frame_Shift_Del_p.Q948fs|BCORL1_ENST00000303743.5_Frame_Shift_Del_p.Q948fs|BCORL1_ENST00000359304.2_Frame_Shift_Del_p.Q948fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	948					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GAATGAATCAGGGGCCTGAGG	0.577													39	79	---	---	---	---						-	129149592	G	-	129149592	7	5	17	1	0	1	0	1	0	0	0	0	1385	991	35	0	2854	0	BCORL1	23	129149592	Frame_Shift_Del	DEL	G	TCGA-N6-A4VD-01A-11D-A28R-08	9900187	129149592	26120968	100	1220										
BCORL1	63035	broad.mit.edu	37	chrX	129190033	129190034	+	Frame_Shift_Del	DEL	TG	TG	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	cccccaggctcctctgagacTgtggagctggtgcggtacga							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:129190033_129190034delTG	ENST00000540052.1	+	12	5102_5103	c.5058_5059delTG	c.(5056-5061)actgfs	p.TV1686fs	BCORL1_ENST00000218147.7_Frame_Shift_Del_p.TV1686fs|BCORL1_ENST00000303743.5_Frame_Shift_Del_p.TV1760fs|BCORL1_ENST00000359304.2_Frame_Shift_Del_p.TV1556fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1686					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CCTCTGAGACTGTGGAGCTGGT	0.619													26	67	---	---	---	---						-	129190034	TG	-	129190033	7	5	17	1	0	1	0	1	0	0	0	0	1385	1567	55	0	5330	0	BCORL1	23	129190033	Frame_Shift_Del	DEL	TG	TCGA-N6-A4VD-01A-11D-A28R-08	40441	129190033	26080527	101	1221										
UBE2NL	389898	broad.mit.edu	37	chrX	142967368	142967368	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	agggagggacttttaaacgtGaactattacttgcagaagaa	11	5	0	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:142967368G>C	ENST00000370494.1	+	1	196	c.166G>C	c.(166-168)Gaa>Caa	p.E56Q		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	56							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTAAACGTGAACTATTACT	0.408													49	79					0	0	1	0	0	C	142967368	G	C	142967368	3	2	17	1	0	0	0	0	1	0	0	0	16927	1291	45	2	168	2	UBE2NL	23	142967368	Missense_Mutation	SNP	G	TCGA-N6-A4VD-01A-11D-A28R-08	13777335	142967368	12303192	102	1222										
AFF2	2334	broad.mit.edu	37	chrX	147924917	147924917	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tcttttcagagtggaatgacCcaaccaccagagcttctaca	7	12	3	3			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:147924917C>A	ENST00000370460.2	+	7	1701	c.1222C>A	c.(1222-1224)Cca>Aca	p.P408T	AFF2_ENST00000370457.5_Missense_Mutation_p.P375T|AFF2_ENST00000342251.3_Missense_Mutation_p.P375T|AFF2_ENST00000370458.1_Missense_Mutation_p.P375T|AFF2_ENST00000286437.5_Missense_Mutation_p.P49T	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	408					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGAATGACCCAACCACCAG	0.388													23	36					2.21704e-12	2.3358e-12	1	1	0	A	147924917	C	A	147924917	3	1	17	1	0	0	0	0	1	0	0	0	356	623	22	5	1303	5	AFF2	23	147924917	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	4957549	147924917	7345643	103	1223										
MAMLD1	10046	broad.mit.edu	37	chrX	149639633	149639635	+	In_Frame_Del	DEL	GCA	GCA	-													0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gccactgccaccttgcagctGcagcagcagcagcagcaaca							TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:149639633_149639635delGCA	ENST00000370401.2	+	4	2098_2100	c.1788_1790delGCA	c.(1786-1791)ctg>ct	p.LQ596del	MAMLD1_ENST00000426613.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000262858.5_In_Frame_Del_p.LQ596del|MAMLD1_ENST00000455522.2_In_Frame_Del_p.LQ77del			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	596	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTgcagctgcagcagcagcag	0.611													7	155	---	---	---	---						-	149639635	GCA	-	149639633	7	5	17	1	0	1	0	1	0	0	0	0	9257	1306	46	0	1798	0	MAMLD1	23	149639633	In_Frame_Del	DEL	GCA	TCGA-N6-A4VD-01A-11D-A28R-08	1714716	149639633	5630927	104	1224										
PLXNB3	5365	broad.mit.edu	37	chrX	153039479	153039479	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	tcctgtaccagcccaaccccCgcctggcacccctcagccgc	7	23	1	0			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:153039479C>T	ENST00000538966.1	+	21	3785	c.3514C>T	c.(3514-3516)Cgc>Tgc	p.R1172C	PLXNB3_ENST00000538282.1_Missense_Mutation_p.R759C|PLXNB3_ENST00000361971.5_Missense_Mutation_p.R1149C|PLXNB3_ENST00000538776.1_Missense_Mutation_p.R802C	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1149	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCCAACCCCCGCCTGGCACC	0.687													15	34					0	0	1	0	0	T	153039479	C	T	153039479	3	4	17	1	0	0	0	0	1	0	0	0	12172	652	23	1	3637	1	PLXNB3	23	153039479	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	3399846	153039479	2231081	105	1225										
FLNA	0	broad.mit.edu	37	chrX	153581007	153581007	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0285714285714286	3	1	0.321825095057034	4.02281368821293	0.220428147299339	1	1	0	gggtgatgctctctttcaccCggccctcgcctgtcaccttc	9	17	3	1			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:153581007C>T	ENST00000422373.1	-	39	6640	c.6392G>A	c.(6391-6393)cGg>cAg	p.R2131Q	FLNA_ENST00000360319.4_Missense_Mutation_p.R2131Q|FLNA_ENST00000344736.4_Missense_Mutation_p.R2099Q|FLNA_ENST00000369856.3_Missense_Mutation_p.R272Q|FLNA_ENST00000369850.3_Missense_Mutation_p.R2139Q	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2139					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCTTTCACCCGGCCCTCGCC	0.617													25	37					0	0	1	0	0	T	153581007	C	T	153581007	3	4	17	1	0	0	0	0	1	0	0	0	5965	652	23	1	1563	1	FLNA	23	153581007	Missense_Mutation	SNP	C	TCGA-N6-A4VD-01A-11D-A28R-08	541528	153581007	1689553	106	1226										
YARS	8565	broad.mit.edu	37	chr1	33245110	33245110	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggtccagaggttcaacctggCggtttatcccttctctggga	12	11	2	1	rs147005844	byFrequency	TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr1:33245110C>T	ENST00000373477.4	-	12	2257	c.1349G>A	c.(1348-1350)cGc>cAc	p.R450H	YARS_ENST00000469100.1_5'UTR	NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	450	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity	p.R450H(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TTCAACCTGGCGGTTTATCCC	0.557													19	29					0	0	1	0	0	T	33245110	C	T	33245110	3	4	18	1	0	0	0	0	1	0	0	0	17526	768	27	1	245	1	YARS	1	33245110	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		33245110	216005511	1	1227										
CYP4B1	1580	broad.mit.edu	37	chr1	47284343	47284343	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ttgccatgagtgagatgaagGtggtcacagccatgtgcttg	14	7	1	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr1:47284343G>C	ENST00000271153.4	+	12	1429	c.1393G>C	c.(1393-1395)Gtg>Ctg	p.V465L	CYP4B1_ENST00000371923.4_Missense_Mutation_p.V466L|CYP4B1_ENST00000371919.4_Missense_Mutation_p.V451L|CYP4B1_ENST00000452782.2_Missense_Mutation_p.V303L			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	465					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TGAGATGAAGGTGGTCACAGC	0.537													56	43					0	0	1	0	0	C	47284343	G	C	47284343	3	2	18	1	0	0	0	0	1	0	0	0	4208	1261	44	5	1442	5	CYP4B1	1	47284343	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	14039233	47284343	201966278	2	1228										
ZNF326	284695	broad.mit.edu	37	chr1	90484253	90484253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ttgttttctaggagtgtatgGtgaataaattcaagaaaaca	9	3	2	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr1:90484253G>A	ENST00000340281.4	+	9	1227	c.1084G>A	c.(1084-1086)Gtg>Atg	p.V362M	ZNF326_ENST00000370447.2_Missense_Mutation_p.V273M|ZNF326_ENST00000455342.2_Missense_Mutation_p.V156M	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		GGAGTGTATGGTGAATAAATT	0.289													12	11					0	0	1	0	0	A	90484253	G	A	90484253	3	1	18	1	0	0	0	0	1	0	0	0	17902	1261	44	3	1122	3	ZNF326	1	90484253	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	43199910	90484253	158766368	3	1229										
COL11A1	1301	broad.mit.edu	37	chr1	103470202	103470202	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aggaggacctggaggaccttGaggacctcgttcaccctgtt	13	11	1	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr1:103470202G>T	ENST00000358392.2	-	19	2214	c.1897C>A	c.(1897-1899)Caa>Aaa	p.Q633K	COL11A1_ENST00000353414.4_Missense_Mutation_p.Q582K|COL11A1_ENST00000370096.3_Missense_Mutation_p.Q621K|COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000512756.1_Missense_Mutation_p.Q505K	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	621	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGAGGACCTTGAGGACCTCGT	0.323													4	13					0.184627	0.186492	1	1	0	T	103470202	G	T	103470202	3	4	18	1	0	0	0	0	1	0	0	0	3690	1299	45	2	3755	2	COL11A1	1	103470202	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	12985949	103470202	145780419	4	1230										
KCNA3	3738	broad.mit.edu	37	chr1	111217391	111217393	+	In_Frame_Del	DEL	GGC	GGC	-													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gggcgcggtggcgggctgagGgcggcggcggcgagcgcaga							TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr1:111217391_111217393delGGC	ENST00000369769.2	-	1	262_264	c.39_41delGCC	c.(37-42)ccc>cc	p.PP13del		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	13						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGGGCTGAGGGCGGCGGCGGCG	0.768													2	4	---	---	---	---						-	111217393	GGC	-	111217391	7	5	18	1	0	1	0	1	0	0	0	0	8047	1232	43	0	1690	0	KCNA3	1	111217391	In_Frame_Del	DEL	GGC	TCGA-N6-A4VE-01A-11D-A28R-08	7747189	111217391	138033230	5	1231										
LYST	1130	broad.mit.edu	37	chr1	235972583	235972583	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gacctgagagatctcggtgaTgatgcataaaatgagaatat	11	5	1	5			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr1:235972583T>C	ENST00000389794.3	-	5	1709	c.1535A>G	c.(1534-1536)cAt>cGt	p.H512R	LYST_ENST00000536965.1_Missense_Mutation_p.H512R|LYST_ENST00000389793.2_Missense_Mutation_p.H512R			Q99698	LYST_HUMAN	lysosomal trafficking regulator	512					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATCTCGGTGATGATGCATAAA	0.383													44	23					0	0	1	0	0	C	235972583	T	C	235972583	3	2	18	1	0	0	0	0	1	0	0	0	9173	1464	51	4	10066	4	LYST	1	235972583	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	124755192	235972583	13278038	6	1232										
PXDN	7837	broad.mit.edu	37	chr2	1652949	1652949	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	agcgggccccgctcctggccCgggagtcattgggggggatc	18	13	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:1652949C>T	ENST00000252804.4	-	17	2653	c.2603G>A	c.(2602-2604)cGg>cAg	p.R868Q		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	868					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GCTCCTGGCCCGGGAGTCATT	0.662													17	31					0	0	1	0	0	T	1652949	C	T	1652949	3	4	18	1	0	0	0	0	1	0	0	0	12898	652	23	1	1864	1	PXDN	2	1652949	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		1652949	241546424	7	1233										
ADAM17	6868	broad.mit.edu	37	chr2	9663433	9663433	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cattatcccatgaagtgttcCgatagatgtcatcaactctg	7	10	3	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:9663433C>T	ENST00000310823.3	-	7	970	c.788G>A	c.(787-789)cGg>cAg	p.R263Q	ADAM17_ENST00000497134.1_Missense_Mutation_p.R263Q	NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	263	Peptidase M12B.				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TGAAGTGTTCCGATAGATGTC	0.323													34	28					0	0	1	0	0	T	9663433	C	T	9663433	3	4	18	1	0	0	0	0	1	0	0	0	237	652	23	1	1738	1	ADAM17	2	9663433	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	8010484	9663433	233535940	8	1234										
XDH	7498	broad.mit.edu	37	chr2	31605884	31605884	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	caccgccacagacttgacttGcttcccagcaaaccagcgca	7	17	0	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:31605884G>C	ENST00000379416.3	-	11	1069	c.1021C>G	c.(1021-1023)Caa>Gaa	p.Q341E	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	341	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GACTTGACTTGCTTCCCAGCA	0.557													32	22					0	0	1	0	0	C	31605884	G	C	31605884	3	2	18	1	0	0	0	0	1	0	0	0	17485	1328	46	5	3084	5	XDH	2	31605884	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	21942451	31605884	211593489	9	1235										
EDAR	10913	broad.mit.edu	37	chr2	109513391	109513391	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cagcatgtggctgggaggcaGgtggcacaacccccgcccac	14	15	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:109513391G>C	ENST00000409271.1	-	12	1858	c.1415C>G	c.(1414-1416)cCt>cGt	p.P472R	EDAR_ENST00000376651.1_Missense_Mutation_p.P472R|EDAR_ENST00000258443.2_Missense_Mutation_p.P440R			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	440					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CTGGGAGGCAGGTGGCACAAC	0.592													12	9					0	0	1	0	0	C	109513391	G	C	109513391	3	2	18	1	0	0	0	0	1	0	0	0	4931	1000	35	5	31	5	EDAR	2	109513391	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	77907507	109513391	133685982	10	1236										
CACNB4	785	broad.mit.edu	37	chr2	152711818	152711818	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tgctgggtgattgatggtgtCtgcatcaagaacaaccagtt	12	7	2	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:152711818C>A	ENST00000360283.6	-	10	1098	c.841G>T	c.(841-843)Gac>Tac	p.D281Y	CACNB4_ENST00000201943.5_Missense_Mutation_p.D314Y|CACNB4_ENST00000397327.2_Missense_Mutation_p.D267Y|CACNB4_ENST00000539935.1_Missense_Mutation_p.D314Y|CACNB4_ENST00000534999.1_Missense_Mutation_p.D280Y|CACNB4_ENST00000427385.1_Missense_Mutation_p.D296Y			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	314					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	TTGATGGTGTCTGCATCAAGA	0.373													5	33					1.23904e-05	1.31813e-05	1	1	0	A	152711818	C	A	152711818	3	1	18	1	0	0	0	0	1	0	0	0	2573	913	32	2	638	2	CACNB4	2	152711818	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	43198427	152711818	90487555	11	1237										
SCN7A	6332	broad.mit.edu	37	chr2	167289081	167289081	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	taacatatacctcatttacaTggtccattgtgtcctttggg	7	9	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:167289081T>A	ENST00000409855.1	-	15	2465	c.2339A>T	c.(2338-2340)cAt>cTt	p.H780L		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	780					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CTCATTTACATGGTCCATTGT	0.353													41	57					0	0	1	0	0	A	167289081	T	A	167289081	3	1	18	1	0	0	0	0	1	0	0	0	13976	1464	51	4	2753	4	SCN7A	2	167289081	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	14577263	167289081	75910292	12	1238										
SCLY	51540	broad.mit.edu	37	chr2	238999914	238999914	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aggtgagccctggtgagcttGaggagatgagttgattgctt	16	5	0	6			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr2:238999914G>C	ENST00000409736.2	+	8	964	c.940G>C	c.(940-942)Gag>Cag	p.E314Q	SCLY_ENST00000422984.2_Intron|SCLY_ENST00000373332.3_Missense_Mutation_p.E232Q|SCLY_ENST00000555827.1_Intron|SCLY_ENST00000254663.6_Intron|SCLY_ENST00000429612.2_Intron			Q96I15	SCLY_HUMAN	selenocysteine lyase	0					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	22		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		TGGTGAGCTTGAGGAGATGAG	0.478													22	86					0	0	1	0	0	C	238999914	G	C	238999914	3	2	18	1	0	0	0	0	1	0	0	0	13960	1305	45	2		2	SCLY	2	238999914	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	71710833	238999914	4199459	13	1239										
CSRNP1	64651	broad.mit.edu	37	chr3	39185088	39185088	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gttccccacgctcccttcctCctcttcctcctcctccccac	2	25	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr3:39185088C>G	ENST00000273153.5	-	5	1405	c.1228G>C	c.(1228-1230)Gag>Cag	p.E410Q	CSRNP1_ENST00000514182.1_Missense_Mutation_p.E410Q	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	410					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						CTCCCTTCCTCCTCTTCCTCC	0.602													11	49					0	0	1	0	0	G	39185088	C	G	39185088	3	3	18	1	0	0	0	0	1	0	0	0	3988	864	30	2	545	2	CSRNP1	3	39185088	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		39185088	158837342	14	1240										
LSAMP	4045	broad.mit.edu	37	chr3	115805175	115805175	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cccacactttccttaccttgTacgatcaagtaaacttggga	6	12	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr3:115805175T>C	ENST00000490035.1	-	2	883	c.384A>G	c.(382-384)gtA>gtG	p.V128V	LSAMP_ENST00000539563.1_Silent_p.V125V	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	128					cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CCTTACCTTGTACGATCAAGT	0.438													10	45					0	0	1	0	0	C	115805175	T	C	115805175	2	2	18	1	0	0	0	0	0	0	0	1	9092	1625	57	4		4	LSAMP	3	115805175	Silent	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	76620087	115805175	82217255	15	1241										
MGLL	11343	broad.mit.edu	37	chr3	127439984	127439984	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggcccggcctctctgcggccGtgaggatggcgatggcgcct	17	14	1	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr3:127439984G>C	ENST00000434178.2	-	5	1288	c.392C>G	c.(391-393)aCg>aGg	p.T131R	MGLL_ENST00000265052.5_Missense_Mutation_p.T141R|MGLL_ENST00000398104.1_Missense_Mutation_p.T131R|MGLL_ENST00000453507.2_Missense_Mutation_p.T141R|MGLL_ENST00000398101.3_Missense_Mutation_p.T105R			Q99685	MGLL_HUMAN	monoglyceride lipase	131					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						CTCTGCGGCCGTGAGGATGGC	0.537													22	60					0	0	1	0	0	C	127439984	G	C	127439984	3	2	18	1	0	0	0	0	1	0	0	0	9604	1145	40	5	535	5	MGLL	3	127439984	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	11634809	127439984	70582446	16	1242										
GPR149	344758	broad.mit.edu	37	chr3	154056029	154056029	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	acacagtcccctggaatgcaCacaagggaatggcaagggca	12	11	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr3:154056029C>A	ENST00000389740.2	-	4	1754	c.1655G>T	c.(1654-1656)tGt>tTt	p.C552F		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	552						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CTGGAATGCACACAAGGGAAT	0.448													61	135					3.7469e-33	4.56939e-33	1	1	0	A	154056029	C	A	154056029	3	1	18	1	0	0	0	0	1	0	0	0	6693	478	17	5	544	5	GPR149	3	154056029	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	26616045	154056029	43966401	17	1243										
WDR19	57728	broad.mit.edu	37	chr4	39230233	39230233	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aacatctaccttagcacccaTggctttctcagcaacttaaa	4	13	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr4:39230233T>C	ENST00000399820.3	+	17	2059	c.1905T>C	c.(1903-1905)caT>caC	p.H635H	WDR19_ENST00000515631.1_3'UTR|WDR19_ENST00000288634.7_Silent_p.H475H	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	635					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TTAGCACCCATGGCTTTCTCA	0.428													46	44					0	0	1	0	0	C	39230233	T	C	39230233	2	2	18	1	0	0	0	0	0	0	0	1	17338	1461	51	4		4	WDR19	4	39230233	Silent	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08		39230233	151924043	18	1244										
PTPN13	0	broad.mit.edu	37	chr4	87696407	87696407	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tccaaaacagtcagattagtTattggacgagttctagaatt	8	6	2	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr4:87696407T>A	ENST00000436978.1	+	34	6087	c.5607T>A	c.(5605-5607)gtT>gtA	p.V1869V	PTPN13_ENST00000411767.2_Silent_p.V1864V|PTPN13_ENST00000427191.2_Silent_p.V1845V|PTPN13_ENST00000316707.6_Silent_p.V1673V|PTPN13_ENST00000511467.1_Silent_p.V1869V	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1864						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAGATTAGTTATTGGACGAG	0.388													4	23					0	0	1	0	0	A	87696407	T	A	87696407	2	1	18	1	0	0	0	0	0	0	0	1	12831	1741	61	4		4	PTPN13	4	87696407	Silent	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	48466174	87696407	103457869	19	1245										
NAA15	80155	broad.mit.edu	37	chr4	140278710	140278710	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tgaaagctaaaatctataagGtaaaaatctttttttctatt	4	4	3	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr4:140278710G>A	ENST00000296543.5	+	11	1580		c.e11+1		NAA15_ENST00000398947.1_Splice_Site	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AATCTATAAGGTAAAAATCTT	0.284													6	4					0	0	1	0	0	A	140278710	G	A	140278710	5	1	18	1	0	0	0	0	0	0	1	0	10165	1275	44	3	1300	3	NAA15	4	140278710	Splice_Site	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	52582303	140278710	50875566	20	1246										
FBXW7	0	broad.mit.edu	37	chr4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aaaccctaagagtggcatctCgagaaccgctaacaactctg	8	12	2	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr4:153247366C>T	ENST00000281708.4	-	10	2665	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	FBXW7_ENST00000393956.3_Missense_Mutation_p.R303Q|FBXW7_ENST00000296555.5_Missense_Mutation_p.R361Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000263981.5_Missense_Mutation_p.R399Q|FBXW7_ENST00000603548.1_Missense_Mutation_p.R479Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	479					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R479Q(29)|p.R479L(5)|p.R399Q(3)|p.R479P(2)|p.R240L(1)|p.R361P(1)|p.R399P(1)|p.?(1)|p.R361Q(1)|p.R399L(1)|p.R240Q(1)|p.R240P(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								9	32					0	0	1	0	0	T	153247366	C	T	153247366	3	4	18	1	0	0	0	0	1	0	0	0	5801	884	31	1	699	1	FBXW7	4	153247366	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	12968656	153247366	37906910	21	1247										
PTGER4	5734	broad.mit.edu	37	chr5	40691917	40691917	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	accagttatatcagccaagtTtggagcgagaagtcagtaaa	10	7	2	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr5:40691917T>C	ENST00000302472.3	+	3	1928	c.904T>C	c.(904-906)Ttg>Ctg	p.L302L		NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	302					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						TCAGCCAAGTTTGGAGCGAGA	0.413													17	72					0	0	1	0	0	C	40691917	T	C	40691917	2	2	18	1	0	0	0	0	0	0	0	1	12794	1838	64	4		4	PTGER4	5	40691917	Silent	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08		40691917	140223343	22	1248										
SIL1	64374	broad.mit.edu	37	chr5	138282944	138282944	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gccagtgtcctgccgagctgGgggtcctgacggtagcggtc	17	12	0	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr5:138282944G>C	ENST00000394817.2	-	10	1387	c.1248C>G	c.(1246-1248)ccC>ccG	p.P416P	SIL1_ENST00000515008.1_5'UTR|SIL1_ENST00000265195.5_Silent_p.P416P|SIL1_ENST00000509534.1_Silent_p.P423P	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor	416					intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGCCGAGCTGGGGGTCCTGAC	0.677									Marinesco-Sjgren syndrome				34	21					0	0	1	0	0	C	138282944	G	C	138282944	2	2	18	1	0	0	0	0	0	0	0	1	14375	1219	43	5		5	SIL1	5	138282944	Silent	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	97591027	138282944	42632316	23	1249										
FAT2	2196	broad.mit.edu	37	chr5	150889670	150889670	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ttccaggcagggtgcaaaagTacagttctcccttccttgtt	9	11	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr5:150889670T>G	ENST00000261800.5	-	21	11983	c.11971A>C	c.(11971-11973)Act>Cct	p.T3991P	CTC-251D13.1_ENST00000606930.1_RNA	NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3991	EGF-like 2.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTGCAAAAGTACAGTTCTCC	0.522													6	141					0	0	1	0	0	G	150889670	T	G	150889670	3	3	18	1	0	0	0	0	1	0	0	0	5722	1638	57	4	1090	4	FAT2	5	150889670	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	12606726	150889670	30025590	24	1250										
OR5V1	81696	broad.mit.edu	37	chr6	29323301	29323301	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gaggactggatcctcaagatGgtggagattatgcaaatgta	13	5	1	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr6:29323301G>T	ENST00000377154.1	-	4	971	c.672C>A	c.(670-672)acC>acA	p.T224T	OR5V1_ENST00000543825.1_Silent_p.T224T			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TCCTCAAGATGGTGGAGATTA	0.468													29	163					1.16021e-09	1.28912e-09	1	1	0	T	29323301	G	T	29323301	2	4	18	1	0	0	0	0	0	0	0	1	11230	1335	47	5		5	OR5V1	6	29323301	Silent	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08		29323301	141791766	25	1251										
PRPH2	5961	broad.mit.edu	37	chr6	42689572	42689572	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cagtcccgaaaaccgttgttGccgcagcatttgaactcgat	9	12	0	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr6:42689572G>T	ENST00000230381.5	-	1	740	c.501C>A	c.(499-501)ggC>ggA	p.G167G		NM_000322.4	NP_000313.2	P23942	PRPH2_HUMAN	peripherin 2 (retinal degeneration, slow)	167			G -> D (in PDREP; butterfly-shaped).|G -> S (in PDREP; butterfly-shaped).		cell adhesion|visual perception	integral to membrane				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	18	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			AACCGTTGTTGCCGCAGCATT	0.502													22	234					7.41877e-09	8.06388e-09	1	1	0	T	42689572	G	T	42689572	2	4	18	1	0	0	0	0	0	0	0	1	12628	1306	46	5		5	PRPH2	6	42689572	Silent	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	13366271	42689572	128425495	26	1252										
GABRR2	2570	broad.mit.edu	37	chr6	90024791	90024791	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ccttggcttgggcatttccaCctgccctgtccatcgcttcc	8	17	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr6:90024791C>A	ENST00000402938.3	-	1	227	c.94G>T	c.(94-96)Gtg>Ttg	p.V32L	GABRR2_ENST00000602808.1_5'UTR|GABRR2_ENST00000602399.1_Missense_Mutation_p.V57L			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	57					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		GGCATTTCCACCTGCCCTGTC	0.507													10	215					1.58986e-06	1.70953e-06	1	1	0	A	90024791	C	A	90024791	3	1	18	1	0	0	0	0	1	0	0	0	6211	507	18	5	1339	5	GABRR2	6	90024791	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	47335219	90024791	81090276	27	1253										
FNDC1	84624	broad.mit.edu	37	chr6	159642727	159642727	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ctaacaaagcgaaagatttcAggtatgtttctaaggatgca	9	6	2	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr6:159642727A>T	ENST00000297267.9	+	6	965	c.766_splice	c.e6+1	p.S255_splice	FNDC1_ENST00000480856.1_3'UTR|FNDC1_ENST00000340366.6_Splice_Site_p.S255_splice	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	255						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GAAAGATTTCAGGTATGTTTC	0.453													3	33					0	0	1	0	0	T	159642727	A	T	159642727	5	4	18	1	0	0	0	0	0	0	1	0	6000	202	7	4	787	4	FNDC1	6	159642727	Splice_Site	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	69617936	159642727	11472340	28	1254										
PCLO	27445	broad.mit.edu	37	chr7	82764634	82764634	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tcagcaacaggggccttgtcCtgctcagatgggacagaagg	14	10	2	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr7:82764634C>T	ENST00000423517.2	-	3	2569	c.2232G>A	c.(2230-2232)caG>caA	p.Q744Q	PCLO_ENST00000333891.8_Silent_p.Q744Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	690	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGGCCTTGTCCTGCTCAGATG	0.517													14	40					0	0	1	0	0	T	82764634	C	T	82764634	2	4	18	1	0	0	0	0	0	0	0	1	11629	680	24	3		3	PCLO	7	82764634	Silent	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		82764634	76374029	29	1255										
GRM3	0	broad.mit.edu	37	chr7	86416020	86416020	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gtggccagcgacggctggggCgcgcaggagagcatcatcaa	17	11	2	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr7:86416020C>T	ENST00000361669.2	+	3	2011	c.912C>T	c.(910-912)ggC>ggT	p.G304G	GRM3_ENST00000394720.2_Silent_p.G302G|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.G304G|GRM3_ENST00000536043.1_Silent_p.G176G	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	304					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ACGGCTGGGGCGCGCAGGAGA	0.677													19	49					0	0	1	0	0	T	86416020	C	T	86416020	2	4	18	1	0	0	0	0	0	0	0	1	6838	755	27	1		1	GRM3	7	86416020	Silent	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	3651386	86416020	72722643	30	1256										
ADAM22	53616	broad.mit.edu	37	chr7	87780297	87780297	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gttgttctctttttcctagtGtgcccctaatattcataaaa	5	9	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr7:87780297G>A	ENST00000398204.4	+	19	1891	c.1566_splice	c.e19-1	p.C523_splice	ADAM22_ENST00000398201.4_Splice_Site_p.C523_splice|ADAM22_ENST00000265727.7_Splice_Site_p.C523_splice|ADAM22_ENST00000398209.3_Splice_Site_p.C523_splice|ADAM22_ENST00000315984.7_Splice_Site_p.C523_splice	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	523	Disintegrin.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TTTTCCTAGTGTGCCCCTAAT	0.328													25	15					0	0	1	0	0	A	87780297	G	A	87780297	5	1	18	1	0	0	0	0	0	0	1	0	243	1391	48	3	1642	3	ADAM22	7	87780297	Splice_Site	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	1364277	87780297	71358366	31	1257										
TMEM130	222865	broad.mit.edu	37	chr7	98457843	98457843	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tagagaaacaaggcggtcttGaggaagttgctcgggtcgtg	16	6	1	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr7:98457843G>C	ENST00000450876.1	-	3	1573	c.258C>G	c.(256-258)ctC>ctG	p.L86L	TMEM130_ENST00000339375.4_Silent_p.L170L|TMEM130_ENST00000345589.4_Silent_p.L68L|TMEM130_ENST00000546258.1_Silent_p.L151L|TMEM130_ENST00000416379.2_Silent_p.L170L			Q8N3G9	TM130_HUMAN	transmembrane protein 130	170						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGGCGGTCTTGAGGAAGTTGC	0.592													14	29					0	0	1	0	0	C	98457843	G	C	98457843	2	2	18	1	0	0	0	0	0	0	0	1	16102	1277	45	2		2	TMEM130	7	98457843	Silent	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	10677546	98457843	60680820	32	1258										
VPS13B	157680	broad.mit.edu	37	chr8	100733115	100733115	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tttgaaattgcctggggtctAtgaagtcttattttataatg	9	4	2	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr8:100733115A>G	ENST00000358544.2	+	39	7076	c.6965A>G	c.(6964-6966)tAt>tGt	p.Y2322C	VPS13B_ENST00000357162.2_Missense_Mutation_p.Y2297C|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2322					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTGGGGTCTATGAAGTCTTA	0.348													14	21					0	0	1	0	0	G	100733115	A	G	100733115	3	3	18	1	0	0	0	0	1	0	0	0	17249	449	16	4	7309	4	VPS13B	8	100733115	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08		100733115	45630907	33	1259										
NFX1	0	broad.mit.edu	37	chr9	33295250	33295250	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cccattccaaaggatgacctCaatgaaagaccagcaaaatc	6	12	1	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr9:33295250C>T	ENST00000379540.3	+	2	920	c.858C>T	c.(856-858)ctC>ctT	p.L286L	NFX1_ENST00000379521.4_Silent_p.L286L|NFX1_ENST00000318524.6_Silent_p.L286L	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	286					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		AGGATGACCTCAATGAAAGAC	0.512													26	17					0	0	1	0	0	T	33295250	C	T	33295250	2	4	18	1	0	0	0	0	0	0	0	1	10433	813	29	3		3	NFX1	9	33295250	Silent	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		33295250	107918181	34	1260										
BRD3	8019	broad.mit.edu	37	chr9	136915512	136915512	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tcaccttgacgacaggcggcGtaggagggaccacggggacg	17	11	1	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr9:136915512G>T	ENST00000303407.7	-	5	883	c.698C>A	c.(697-699)aCg>aAg	p.T233K	BRD3_ENST00000357885.2_Missense_Mutation_p.T233K|BRD3_ENST00000371834.2_Missense_Mutation_p.T233K	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	233						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		GACAGGCGGCGTAGGAGGGAC	0.692			T	C15orf55	lethal midline carcinoma of young people								57	2					1.74971e-23	2.10809e-23	1	1	0	T	136915512	G	T	136915512	3	4	18	1	0	0	0	0	1	0	0	0	1505	1145	40	5	1514	5	BRD3	9	136915512	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	103620262	136915512	4297919	35	1261										
MAN1B1	11253	broad.mit.edu	37	chr9	139981513	139981513	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ctctcagtcggacttcctgaCgccgccagtgggcggggccc	14	16	1	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr9:139981513C>G	ENST00000371589.4	+	1	135	c.62C>G	c.(61-63)aCg>aGg	p.T21R		NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	21					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GACTTCCTGACGCCGCCAGTG	0.687													4	10					0	0	1	0	0	G	139981513	C	G	139981513	3	3	18	1	0	0	0	0	1	0	0	0	9261	536	19	5	64	5	MAN1B1	9	139981513	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	3066001	139981513	1231918	36	1262										
CXCL12	6387	broad.mit.edu	37	chr10	44873206	44873206	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cagggggaccattacacatcCccaggagagggccagctcca	12	14	0	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr10:44873206C>A	ENST00000395794.2	-	4	457	c.414G>T	c.(412-414)ggG>ggT	p.G138G	CXCL12_ENST00000374426.2_Intron|CXCL12_ENST00000374429.2_Intron|CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000395795.4_Intron|CXCL12_ENST00000343575.6_3'UTR	NM_001178134.1	NP_001171605.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	ATTACACATCCCCAGGAGAGG	0.547													16	11					4.14922e-12	4.88143e-12	1	1	0	A	44873206	C	A	44873206	2	1	18	1	0	0	0	0	0	0	0	1	4103	610	22	5		5	CXCL12	10	44873206	Silent	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		44873206	90661541	37	1263										
HIF1AN	55662	broad.mit.edu	37	chr10	102300458	102300458	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tcatggacttcttaggttttAactggaactggattaataag	9	5	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr10:102300458A>C	ENST00000299163.5	+	3	596	c.496A>C	c.(496-498)Aac>Cac	p.N166H	HIF1AN_ENST00000528044.1_3'UTR	NM_017902.2	NP_060372.2	Q9NWT6	HIF1N_HUMAN	hypoxia inducible factor 1, alpha subunit inhibitor	166	Interaction with HIF1A.|Interaction with VHL.|JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	10		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		CTTAGGTTTTAACTGGAACTG	0.448													39	7					0	0	1	0	0	C	102300458	A	C	102300458	3	2	18	1	0	0	0	0	1	0	0	0	7144	362	13	4	506	4	HIF1AN	10	102300458	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	57427252	102300458	33234289	38	1264										
OR4C3	256144	broad.mit.edu	37	chr11	48347056	48347056	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ttggttcagctcctcctggtCctttggttgcccttctgtgg	11	12	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr11:48347056C>A	ENST00000319856.4	+	1	585	c.564C>A	c.(562-564)gtC>gtA	p.V188V		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TCCTCCTGGTCCTTTGGTTGC	0.517													7	83					1.02788e-11	1.18148e-11	1	1	0	A	48347056	C	A	48347056	2	1	18	1	0	0	0	0	0	0	0	1	11097	842	30	2		2	OR4C3	11	48347056	Silent	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		48347056	86659460	39	1265										
IL18BP	10068	broad.mit.edu	37	chr11	71712330	71712332	+	In_Frame_Del	DEL	ATT	ATT	-													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggctgggcaatggttccttcAttgagcacctcccaggccga							TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr11:71712330_71712332delATT	ENST00000497194.2	+	3	1691_1693	c.319_321delATT	c.(319-321)del	p.I107del	IL18BP_ENST00000260049.5_In_Frame_Del_p.I107del|IL18BP_ENST00000393703.4_In_Frame_Del_p.I107del|IL18BP_ENST00000531053.1_In_Frame_Del_p.I107del|IL18BP_ENST00000393705.4_In_Frame_Del_p.I107del|IL18BP_ENST00000393707.4_Intron|IL18BP_ENST00000337131.5_In_Frame_Del_p.I107del|IL18BP_ENST00000404792.1_In_Frame_Del_p.I107del			O95998	I18BP_HUMAN	interleukin 18 binding protein	107	Ig-like C2-type.				T-helper 1 type immune response	extracellular region	interleukin-18 binding|receptor antagonist activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)	7						TGGTTCCTTCATTGAGCACCTCC	0.611													30	26	---	---	---	---						-	71712332	ATT	-	71712330	7	5	18	1	0	1	0	1	0	0	0	0	7689	217	8	0	329	0	IL18BP	11	71712330	In_Frame_Del	DEL	ATT	TCGA-N6-A4VE-01A-11D-A28R-08	23365274	71712330	63294186	40	1266										
PHLDB1	23187	broad.mit.edu	37	chr11	118506246	118506246	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggagcaaggctgagctgctcCgcagcatcgccaagaggaag	15	11	0	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr11:118506246C>G	ENST00000361417.2	+	11	2926	c.2515C>G	c.(2515-2517)Cgc>Ggc	p.R839G	PHLDB1_ENST00000356063.5_Missense_Mutation_p.R839G|PHLDB1_ENST00000534672.1_3'UTR	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	839										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TGAGCTGCTCCGCAGCATCGC	0.632													17	56					0	0	1	0	0	G	118506246	C	G	118506246	3	3	18	1	0	0	0	0	1	0	0	0	11898	652	23	5	2549	5	PHLDB1	11	118506246	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	46793916	118506246	16500270	41	1267										
CHD4	1108	broad.mit.edu	37	chr12	6696569	6696569	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cccccatttcttcttcccgtAccacatactgggccactttg	5	17	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:6696569A>C	ENST00000309577.6	-	25	4023	c.3860T>G	c.(3859-3861)gTa>gGa	p.V1287G	CHD4_ENST00000544484.1_Missense_Mutation_p.V1284G|CHD4_ENST00000357008.2_Missense_Mutation_p.V1287G|CHD4_ENST00000544040.1_Missense_Mutation_p.V1280G|CHD4_ENST00000540960.1_5'UTR			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1287					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TTCTTCCCGTACCACATACTG	0.448													35	66					0	0	1	0	0	C	6696569	A	C	6696569	3	2	18	1	0	0	0	0	1	0	0	0	3349	391	14	4	1942	4	CHD4	12	6696569	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08		6696569	127155326	42	1268										
A2ML1	144568	broad.mit.edu	37	chr12	8995770	8995770	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cttagtatataatccggaacAagtgccacgttactaccaaa	6	10	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:8995770A>C	ENST00000299698.7	+	12	1469	c.1289A>C	c.(1288-1290)cAa>cCa	p.Q430P		NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	274						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						AATCCGGAACAAGTGCCACGT	0.483													54	45					0	0	1	0	0	C	8995770	A	C	8995770	3	2	18	1	0	0	0	0	1	0	0	0	5	130	5	4	1335	4	A2ML1	12	8995770	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	2299201	8995770	124856125	43	1269										
TAS2R30	259293	broad.mit.edu	37	chr12	11286029	11286029	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggatgaatgggtgggttgaaGgatagctgaatataatagct	15	2	0	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:11286029G>A	ENST00000539585.1	-	1	1214	c.815C>T	c.(814-816)cCt>cTt	p.P272L	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_001097643.1	NP_001091112.1			taste receptor, type 2, member 30											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						GTGGGTTGAAGGATAGCTGAA	0.413													94	52					0	0	1	0	0	A	11286029	G	A	11286029	3	1	18	1	0	0	0	0	1	0	0	0	15629	1000	35	3	148	3	TAS2R30	12	11286029	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	2290259	11286029	122565866	44	1270			1	4		2	2	17	N	T_G	4.083035e-05
TAS2R30	259293	broad.mit.edu	37	chr12	11286045	11286045	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tgaaggatagctgaatataaTagcttggcagaacatgaaga	11	4	0	5			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:11286045T>C	ENST00000539585.1	-	1	1198	c.799A>G	c.(799-801)Att>Gtt	p.I267V	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_001097643.1	NP_001091112.1			taste receptor, type 2, member 30											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						CTGAATATAATAGCTTGGCAG	0.398													97	58					0	0	1	0	0	C	11286045	T	C	11286045	3	2	18	1	0	0	0	0	1	0	0	0	15629	1406	49	4	164	4	TAS2R30	12	11286045	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	16	11286045	122565850	45	1271			1	4		2	2	17	N	T_G	4.083035e-05
PPHLN1	51535	broad.mit.edu	37	chr12	42745780	42745780	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	acaatagatattacagtcatGttgattaccgagactatgac	7	7	1	4			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:42745780G>A	ENST00000395568.2	+	3	250	c.166G>A	c.(166-168)Gtt>Att	p.V56I	PPHLN1_ENST00000432191.2_Intron|PPHLN1_ENST00000358314.7_Missense_Mutation_p.V56I|PPHLN1_ENST00000550535.1_3'UTR|PPHLN1_ENST00000256678.8_Intron|PPHLN1_ENST00000337898.6_Intron|PPHLN1_ENST00000549190.1_Missense_Mutation_p.V74I|PPHLN1_ENST00000449194.2_Missense_Mutation_p.V56I|PPHLN1_ENST00000552761.1_Intron|PPHLN1_ENST00000317560.9_Intron|PPHLN1_ENST00000395580.3_Missense_Mutation_p.V63I	NM_016488.6	NP_057572.5	Q8NEY8	PPHLN_HUMAN	periphilin 1	56					keratinization	cytoplasm|nucleus				breast(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	16	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		TTACAGTCATGTTGATTACCG	0.423													15	30					0	0	1	0	0	A	42745780	G	A	42745780	3	1	18	1	0	0	0	0	1	0	0	0	12359	1377	48	3	197	3	PPHLN1	12	42745780	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	31459735	42745780	91106115	46	1272										
PUS7L	83448	broad.mit.edu	37	chr12	44148360	44148360	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tatcaggtttaaaggtaaatTtggaattttctttctttgca	7	4	3	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:44148360T>G	ENST00000416848.2	-	2	1177	c.689A>C	c.(688-690)aAa>aCa	p.K230T	PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000344862.5_Missense_Mutation_p.K230T|PUS7L_ENST00000551923.1_Missense_Mutation_p.K230T|PUS7L_ENST00000553166.1_Missense_Mutation_p.K230T	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	230					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		AAAGGTAAATTTGGAATTTTC	0.308													6	40					0	0	1	0	0	G	44148360	T	G	44148360	3	3	18	1	0	0	0	0	1	0	0	0	12885	1841	64	4	1448	4	PUS7L	12	44148360	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	1402580	44148360	89703535	47	1273										
ACVR1B	91	broad.mit.edu	37	chr12	52387803	52387803	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggggaagatgatgcgagagtGttggtatgccaacggcgcag	18	6	0	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:52387803G>T	ENST00000257963.4	+	9	1504	c.1427G>T	c.(1426-1428)tGt>tTt	p.C476F	ACVR1B_ENST00000541224.1_Missense_Mutation_p.C517F|ACVR1B_ENST00000542485.1_Missense_Mutation_p.C424F	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	476	Protein kinase.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	ATGCGAGAGTGTTGGTATGCC	0.607													59	51					2.14255e-21	2.55065e-21	1	1	0	T	52387803	G	T	52387803	3	4	18	1	0	0	0	0	1	0	0	0	220	1377	48	5	1588	5	ACVR1B	12	52387803	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	8239443	52387803	81464092	48	1274										
NR4A1	0	broad.mit.edu	37	chr12	52448894	52448894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggcccggagcggggccccagGtggaagtgaaggccgctgtg	20	11	0	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:52448894G>A	ENST00000545748.1	+	3	1939	c.944G>A	c.(943-945)gGt>gAt	p.G315D	NR4A1_ENST00000243050.1_Missense_Mutation_p.G261D|NR4A1_ENST00000548232.1_Missense_Mutation_p.G261D|NR4A1_ENST00000360284.3_Missense_Mutation_p.G274D|NR4A1_ENST00000550082.1_Missense_Mutation_p.G274D|NR4A1_ENST00000394824.2_Missense_Mutation_p.G261D|NR4A1_ENST00000394825.1_Missense_Mutation_p.G261D			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	261					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GGGGCCCCAGGTGGAAGTGAA	0.612													45	48					0	0	1	0	0	A	52448894	G	A	52448894	3	1	18	1	0	0	0	0	1	0	0	0	10679	1261	44	3	784	3	NR4A1	12	52448894	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	61091	52448894	81403001	49	1275										
RILPL1	353116	broad.mit.edu	37	chr12	124008056	124008056	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	acttaccttcatgcttctggAactcctcctctgagaaattg	6	12	3	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr12:124008056A>T	ENST00000376874.4	-	2	681	c.446T>A	c.(445-447)tTc>tAc	p.F149Y		NM_178314.3	NP_847884.2	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	149					neuroprotection	cytosol				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		ATGCTTCTGGAACTCCTCCTC	0.577													22	79					0	0	1	0	0	T	124008056	A	T	124008056	3	4	18	1	0	0	0	0	1	0	0	0	13410	246	9	4	789	4	RILPL1	12	124008056	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	71559162	124008056	9843839	50	1276										
ELF1	1997	broad.mit.edu	37	chr13	41507845	41507845	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tgcagtagcactgaaggatgGagaggaagccacactgacgg	15	8	0	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr13:41507845G>C	ENST00000239882.3	-	9	1890	c.1576C>G	c.(1576-1578)Cca>Gca	p.P526A	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_Missense_Mutation_p.P502A	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	526					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CTGAAGGATGGAGAGGAAGCC	0.512													45	4					0	0	1	0	0	C	41507845	G	C	41507845	3	2	18	1	0	0	0	0	1	0	0	0	5081	1174	41	2	287	2	ELF1	13	41507845	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08		41507845	73662033	51	1277										
MYCBP2	23077	broad.mit.edu	37	chr13	77713331	77713331	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	taaaaccaccttttacttacGtcaacagggaccagaagact	6	11	1	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr13:77713331G>A	ENST00000360084.5	-	0	7637				MYCBP2_ENST00000544440.2_Splice_Site_p.D2515_splice|MYCBP2_ENST00000357337.6_Splice_Site_p.D2515_splice|MYCBP2_ENST00000407578.2_Splice_Site_p.D2553_splice			O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTTTACTTACGTCAACAGGGA	0.383													4	76					0	0	1	0	0	A	77713331	G	A	77713331	1	1	18	1	0	0	0	0	0	0	0	0	10065	1159	40	1		1	MYCBP2	13	77713331	Translation_Start_Site	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	36205486	77713331	37456547	52	1278										
OR4L1	122742	broad.mit.edu	37	chr14	20528715	20528715	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gaacttgcctttctgtggccAcaatgtcataaacaacatat	6	10	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr14:20528715A>G	ENST00000315683.1	+	1	512	c.512A>G	c.(511-513)cAc>cGc	p.H171R		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TTCTGTGGCCACAATGTCATA	0.398													62	66					0	0	1	0	0	G	20528715	A	G	20528715	3	3	18	1	0	0	0	0	1	0	0	0	11121	159	6	4	514	4	OR4L1	14	20528715	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08		20528715	86820825	53	1279										
MDGA2	161357	broad.mit.edu	37	chr14	47324352	47324352	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	caaacgtagataaacatttaAgacacctaaaaatgacaata	4	7	0	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr14:47324352A>C	ENST00000426342.1	-	15	2610	c.1864T>G	c.(1864-1866)Tta>Gta	p.L622V	MDGA2_ENST00000357362.3_Missense_Mutation_p.L622V|MDGA2_ENST00000439988.2_Missense_Mutation_p.L851V|MDGA2_ENST00000399222.3_Missense_Mutation_p.L53V|MDGA2_ENST00000399232.2_Missense_Mutation_p.L920V	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	851	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						TAAACATTTAAGACACCTAAA	0.308													5	23					0	0	1	0	0	C	47324352	A	C	47324352	3	2	18	1	0	0	0	0	1	0	0	0	9456	69	3	4	331	4	MDGA2	14	47324352	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	26795637	47324352	60025188	54	1280										
TRIP11	9321	broad.mit.edu	37	chr14	92506029	92506029	+	Translation_Start_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gcccccaagccaggacgacaTcgcggcgagtttagagaacg	13	13	0	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr14:92506029T>C	ENST00000267622.4	-	1	374	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	TRIP11_ENST00000555105.1_5'UTR	NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CAGGACGACATCGCGGCGAGT	0.602			T	PDGFRB	AML								6	2					0	0	1	0	0	C	92506029	T	C	92506029	1	2	18	1	0	0	0	0	0	0	0	0	16615	1435	50	4		4	TRIP11	14	92506029	Translation_Start_Site	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	45181677	92506029	14843511	55	1281										
DICER1	23405	broad.mit.edu	37	chr14	95557638	95557638	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	cagcaagcgactcaaaaataTcccccatggcctttggaact	7	13	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr14:95557638T>A	ENST00000526495.1	-	27	5720	c.5429A>T	c.(5428-5430)gAt>gTt	p.D1810V	DICER1_ENST00000527414.1_Missense_Mutation_p.D1810V|DICER1_ENST00000343455.3_Missense_Mutation_p.D1810V|DICER1_ENST00000556045.1_Missense_Mutation_p.D708V|DICER1_ENST00000541352.1_Intron|DICER1_ENST00000393063.1_Missense_Mutation_p.D1810V|DICER1_ENST00000527416.2_5'UTR			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1810	RNase III 2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity	p.D1810A(1)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CTCAAAAATATCCCCCATGGC	0.453			"Mis F, N"		"sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				115	122					0	0	1	0	0	A	95557638	T	A	95557638	3	1	18	1	0	0	0	0	1	0	0	0	4549	1435	50	4	351	4	DICER1	14	95557638	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08	3051609	95557638	11791902	56	1282										
C15orf41	84529	broad.mit.edu	37	chr15	36872095	36872095	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aagctcagtacgacgagataGcccagtgcctagtgtctgtg	12	10	2	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr15:36872095G>T	ENST00000566621.1	+	1	284	c.34G>T	c.(34-36)Gcc>Tcc	p.A12S	C15orf41_ENST00000569302.1_Missense_Mutation_p.A12S|C15orf41_ENST00000437989.2_Missense_Mutation_p.A12S	NM_001130010.1	NP_001123482.1	Q9Y2V0	CO041_HUMAN	chromosome 15 open reading frame 41	12							protein binding			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		CGACGAGATAGCCCAGTGCCT	0.567													8	11					1.26484e-09	1.38994e-09	1	1	0	T	36872095	G	T	36872095	3	4	18	1	0	0	0	0	1	0	0	0	1801	971	34	5	36	5	C15orf41	15	36872095	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08		36872095	65659297	57	1283										
SPTBN5	51332	broad.mit.edu	37	chr15	42178339	42178339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ttggagtgctgtctgtagccGgaagagcagggcctctgcgg	17	9	2	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr15:42178339G>A	ENST00000320955.6	-	7	1341	c.1114C>T	c.(1114-1116)Cgg>Tgg	p.R372W		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	372					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GTCTGTAGCCGGAAGAGCAGG	0.672													12	1					0	0	1	0	0	A	42178339	G	A	42178339	3	1	18	1	0	0	0	0	1	0	0	0	15177	1115	39	1	10158	1	SPTBN5	15	42178339	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	5306244	42178339	60353053	58	1284										
SYNGR3	9143	broad.mit.edu	37	chr16	2042103	2042103	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ttcggcgtcgcgctgggcctCggagccttcctcgcctgcgc	14	17	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr16:2042103C>G	ENST00000248121.2	+	2	386	c.228C>G	c.(226-228)ctC>ctG	p.L76L	SYNGR3_ENST00000562045.1_5'UTR	NM_004209.5	NP_004200.2	O43761	SNG3_HUMAN	synaptogyrin 3	76	MARVEL.				positive regulation of transporter activity	cell junction|integral to plasma membrane|synaptic vesicle				endometrium(1)|lung(2)	3						CGCTGGGCCTCGGAGCCTTCC	0.706													10	5					0	0	1	0	0	G	2042103	C	G	2042103	2	3	18	1	0	0	0	0	0	0	0	1	15506	871	31	2		2	SYNGR3	16	2042103	Silent	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		2042103	88312650	59	1285										
ANKFY1	51479	broad.mit.edu	37	chr17	4071081	4071086	+	In_Frame_Del	DEL	CCCCAC	CCCCAC	-													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ccggggggctcactaagaaaCcccacccagagtcagtacat							TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr17:4071081_4071086delCCCCAC	ENST00000341657.4	-	25	3532_3537	c.3497_3502delGTGGGG	c.(3496-3504)gtt>g	p.GGV1166del	ANKFY1_ENST00000574367.1_In_Frame_Del_p.GGV1167del|CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000570535.1_In_Frame_Del_p.GGV1208del	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	1166						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CACTAAGAAACCCCACCCAGAGTCAG	0.544													19	4	---	---	---	---						-	4071086	CCCCAC	-	4071081	7	5	18	1	0	1	0	1	0	0	0	0	622	507	18	0	11	0	ANKFY1	17	4071081	In_Frame_Del	DEL	CCCCAC	TCGA-N6-A4VE-01A-11D-A28R-08		4071081	77124129	60	1286										
TP53	7157	broad.mit.edu	37	chr17	7577134	7577134	+	Frame_Shift_Del	DEL	G	G	-													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	caaacacgcacctcaaagctGttccgtcccagtagattacc							TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr17:7577134delG	ENST00000420246.2	-	8	936	c.804delC	c.(802-804)aafs	p.N268fs	TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Frame_Shift_Del_p.N268fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.N268fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.N268fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.N268fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	268	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		N -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|N -> H (in sporadic cancers; somatic mutation).|N -> I (in sporadic cancers; somatic mutation).|N -> K (in a sporadic cancer; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> Y (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.N268N(2)|p.?(2)|p.G262_S269delGNLLGRNS(2)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTCAAAGCTGTTCCGTCCCA	0.537		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	2	---	---	---	---						-	7577134	G	-	7577134	7	5	18	1	0	1	0	1	0	0	0	0	16441	1368	48	0	482	0	TP53	17	7577134	Frame_Shift_Del	DEL	G	TCGA-N6-A4VE-01A-11D-A28R-08	3506053	7577134	73618076	61	1287										
TP53	7157	broad.mit.edu	37	chr17	7577552	7577552	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ggcctccggttcatgccgccCatgcaggaactgttacacat	10	14	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr17:7577552C>A	ENST00000420246.2	-	7	861	c.729G>T	c.(727-729)atG>atT	p.M243I	TP53_ENST00000413465.2_Missense_Mutation_p.M243I|TP53_ENST00000455263.2_Missense_Mutation_p.M243I|TP53_ENST00000269305.4_Missense_Mutation_p.M243I|TP53_ENST00000445888.2_Missense_Mutation_p.M243I|TP53_ENST00000359597.4_Missense_Mutation_p.M243I	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	243	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		M -> I (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).|MG -> IC (in a sporadic cancer; somatic mutation).|MG -> IS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.M243I(7)|p.?(5)|p.M243_G244>IC(1)|p.M243fs*18(1)|p.G244fs*3(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.M243T(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCATGCCGCCCATGCAGGAAC	0.582		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	2					4.34311e-12	5.05012e-12	1	1	0	A	7577552	C	A	7577552	3	1	18	1	0	0	0	0	1	0	0	0	16441	594	21	5	561	5	TP53	17	7577552	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	418	7577552	73617658	62	1288										
SCPEP1	59342	broad.mit.edu	37	chr17	55062742	55062742	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tcttctctcttccatagggcGgtccaggcggttctagcact	10	13	4	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr17:55062742G>T	ENST00000262288.3	+	3	284	c.229G>T	c.(229-231)Ggt>Tgt	p.G77C	SCPEP1_ENST00000571898.1_3'UTR	NM_021626.2	NP_067639.1	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1	77					proteolysis	extracellular region	serine-type carboxypeptidase activity	p.G77S(1)		endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	14	Breast(9;2.86e-08)					TCCATAGGGCGGTCCAGGCGG	0.423													17	51					5.01169e-05	5.27547e-05	1	1	0	T	55062742	G	T	55062742	3	4	18	1	0	0	0	0	1	0	0	0	13988	1116	39	5	239	5	SCPEP1	17	55062742	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	47485190	55062742	26132468	63	1289										
PPAN-P2RY11	0	broad.mit.edu	37	chr19	10221193	10221193	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aggaggagctgcaggccatcCtggaagccaaggagaagaag	16	8	0	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:10221193C>A	ENST00000428358.1	+	10	1106	c.934C>A	c.(934-936)Ctg>Atg	p.L312M	PPAN_ENST00000556468.1_Missense_Mutation_p.L312M|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.L312M|PPAN_ENST00000393793.1_Missense_Mutation_p.L259M|PPAN_ENST00000253107.7_Missense_Mutation_p.L312M	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		312					RNA splicing	nucleolus	protein binding	p.L312V(4)		breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GCAGGCCATCCTGGAAGCCAA	0.667													10	150					9.70103e-10	1.09e-09	1	1	0	A	10221193	C	A	10221193	3	1	18	1	0	0	0	0	1	0	0	0	12333	680	24	5	972	5	PPAN-P2RY11	19	10221193	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08		10221193	48907790	64	1290										
GPATCH1	55094	broad.mit.edu	37	chr19	33604672	33604672	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gattcttttttcaattcccaGttcaactttagttggcttac	5	9	3	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:33604672G>T	ENST00000170564.2	+	14	2206		c.e14-1			NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1							catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					TCAATTCCCAGTTCAACTTTA	0.433													15	26					0.000422831	0.000435909	1	1	0	T	33604672	G	T	33604672	5	4	18	1	0	0	0	0	0	0	1	0	6629	1043	36	5	1946	5	GPATCH1	19	33604672	Splice_Site	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	23383479	33604672	25524311	65	1291										
DPF1	0	broad.mit.edu	37	chr19	38713335	38713335	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ctcgatggcctcgcggtagaAgtcctcgcctaggctagagg	14	12	0	2			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:38713335A>C	ENST00000416611.1	-	2	169	c.46T>G	c.(46-48)Ttc>Gtc	p.F16V	DPF1_ENST00000414789.1_5'UTR|DPF1_ENST00000456296.1_Missense_Mutation_p.F16V|DPF1_ENST00000420980.2_Missense_Mutation_p.F42V|DPF1_ENST00000412732.1_5'UTR|DPF1_ENST00000355526.4_Missense_Mutation_p.F42V			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	42					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCGCGGTAGAAGTCCTCGCCT	0.731													8	13					0	0	1	0	0	C	38713335	A	C	38713335	3	2	18	1	0	0	0	0	1	0	0	0	4743	72	3	4	1194	4	DPF1	19	38713335	Missense_Mutation	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	5108663	38713335	20415648	66	1292										
CEACAM20	125931	broad.mit.edu	37	chr19	45024554	45024554	+	RNA	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ctccgggcccggctgccccaGttccagacctcacaggcata	10	18	1	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:45024554G>C	ENST00000454753.1	-	0	1262							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				GGCTGCCCCAGTTCCAGACCT	0.617													26	22					0	0	1	0	0	C	45024554	G	C	45024554	1	2	18	0	1	0	0	0	0	0	0	0	3213	1020	36	5		5	CEACAM20	19	45024554	RNA	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	6311219	45024554	14104429	67	1293										
ZNF808	388558	broad.mit.edu	37	chr19	53058029	53058029	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aagagaattcatactggagaGaaaccatacagatgtcaggt	10	6	2	3			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:53058029G>A	ENST00000359798.4	+	5	2040	c.1860G>A	c.(1858-1860)gaG>gaA	p.E620E		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	620					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		ATACTGGAGAGAAACCATACA	0.398													35	34					0	0	1	0	0	A	53058029	G	A	53058029	2	1	18	1	0	0	0	0	0	0	0	1	18220	933	33	3		3	ZNF808	19	53058029	Silent	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	8033475	53058029	6070954	68	1294										
TNNT1	7138	broad.mit.edu	37	chr19	55653236	55653236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gtcacttacatcgaagtcaaCgcgctccccttctgggatct	8	14	4	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:55653236C>T	ENST00000588981.1	-	7	385	c.181G>A	c.(181-183)Gtt>Att	p.V61I	TNNT1_ENST00000585321.2_5'UTR|TNNT1_ENST00000536926.1_Missense_Mutation_p.V50I|TNNT1_ENST00000291901.8_Missense_Mutation_p.V61I|TNNT1_ENST00000587758.1_Missense_Mutation_p.V50I|TNNT1_ENST00000592920.1_5'UTR|TNNT1_ENST00000588426.1_Intron|TNNT1_ENST00000356783.5_Missense_Mutation_p.V50I|TNNT1_ENST00000587465.2_5'UTR	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	61					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		TCGAAGTCAACGCGCTCCCCT	0.602													23	141					0	0	1	0	0	T	55653236	C	T	55653236	3	4	18	1	0	0	0	0	1	0	0	0	16389	536	19	1	687	1	TNNT1	19	55653236	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	2595207	55653236	3475747	69	1295										
ZNF418	147686	broad.mit.edu	37	chr19	58438844	58438844	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tatttgctaaaggatttcccAcattcccagcaataacattc	4	11	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr19:58438844A>G	ENST00000396147.1	-	4	996	c.705T>C	c.(703-705)tgT>tgC	p.C235C	ZNF418_ENST00000599852.1_Silent_p.C150C|ZNF418_ENST00000595830.1_Silent_p.C235C|ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000425570.3_Silent_p.C256C	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		AGGATTTCCCACATTCCCAGC	0.403													11	55					0	0	1	0	0	G	58438844	A	G	58438844	2	3	18	1	0	0	0	0	0	0	0	1	17951	157	6	4		4	ZNF418	19	58438844	Silent	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	2785608	58438844	690139	70	1296										
CDH4	1002	broad.mit.edu	37	chr20	59829994	59829994	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	aggggaaaagctacttcaagGtaaggcggggtgtggagggg	20	4	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr20:59829994G>T	ENST00000360469.5	+	2	257		c.e2+1			NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)						adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CTACTTCAAGGTAAGGCGGGG	0.483													34	57					1.74807e-11	1.98644e-11	1	1	0	T	59829994	G	T	59829994	5	4	18	1	0	0	0	0	0	0	1	0	3134	1275	44	5	176	5	CDH4	20	59829994	Splice_Site	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08		59829994	3195526	71	1297										
BAGE2	85319	broad.mit.edu	37	chr21	11057307	11057308	+	RNA	INS	-	-	A													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	acagacctggagaagataggINSaaaaaaagcttttatcaaca					rs76234576		TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr21:11057307_11057308insA	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAGAAGATAGGAAAAAAAGCTT	0.342													4	6	---	---	---	---						A	11057308	-	A	11057307	6	5	18	0	1	1	1	0	0	0	0	0	1290	1189	41	0		0	BAGE2	21	11057307	RNA	INS	-	TCGA-N6-A4VE-01A-11D-A28R-08		11057307	37072588	72	1298										
BAGE2	85319	broad.mit.edu	37	chr21	11062428	11062429	+	RNA	DEL	TG	TG	-													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ctacagacttcatttatgtaTgtgtgtgtgtgtacacatat					rs113753618		TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr21:11062428_11062429delTG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATTTATGTATGTGTGTGTGTG	0.297													2	4	---	---	---	---						-	11062429	TG	-	11062428	6	5	18	0	1	1	0	1	0	0	0	0	1290	1479	51	0		0	BAGE2	21	11062428	RNA	DEL	TG	TCGA-N6-A4VE-01A-11D-A28R-08	5121	11062428	37067467	73	1299										
APP	351	broad.mit.edu	37	chr21	27277388	27277388	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gggcgggcatcaacaggctcAactgggcacaggaagcaagg	16	10	2	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr21:27277388A>T	ENST00000357903.3	-	14	2020	c.1852_splice	c.e14-1	p.V618_splice	APP_ENST00000354192.3_Splice_Site_p.V506_splice|APP_ENST00000439274.2_Splice_Site_p.V581_splice|APP_ENST00000348990.5_Splice_Site_p.V562_splice|APP_ENST00000448388.2_Splice_Site_p.V527_splice|APP_ENST00000346798.3_Splice_Site_p.V637_splice|APP_ENST00000440126.3_Splice_Site_p.V613_splice|APP_ENST00000359726.3_Splice_Site_p.V581_splice|APP_ENST00000358918.3_Intron	NM_201413.2	NP_958816.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	637					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				CAACAGGCTCAACTGGGCACA	0.537													10	13					0	0	1	0	0	T	27277388	A	T	27277388	5	4	18	1	0	0	0	0	0	0	1	0	812	144	5	4	417	4	APP	21	27277388	Splice_Site	SNP	A	TCGA-N6-A4VE-01A-11D-A28R-08	16214960	27277388	20852507	74	1300										
ZC3H7B	23264	broad.mit.edu	37	chr22	41739574	41739574	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tcgtgggctcctactacctgTgcaaaggtgggtgggctgca	15	10	0	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr22:41739574T>A	ENST00000352645.4	+	13	1710	c.1453T>A	c.(1453-1455)Tgc>Agc	p.C485S	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.C485S	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	501					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CTACTACCTGTGCAAAGGTGG	0.677													11	12					0	0	1	0	0	A	41739574	T	A	41739574	3	1	18	1	0	0	0	0	1	0	0	0	17631	1696	59	4	1499	4	ZC3H7B	22	41739574	Missense_Mutation	SNP	T	TCGA-N6-A4VE-01A-11D-A28R-08		41739574	9564992	75	1301										
FBLN1	2192	broad.mit.edu	37	chr22	45914649	45914649	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	ctgctcgctgccatatgctaCggaatccaaagaatgcaggt	10	11	0	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chr22:45914649C>T	ENST00000348697.2	+	2	314	c.167C>T	c.(166-168)aCg>aTg	p.T56M	FBLN1_ENST00000402984.3_Missense_Mutation_p.T56M|FBLN1_ENST00000340923.5_Missense_Mutation_p.T56M|FBLN1_ENST00000327858.6_Missense_Mutation_p.T56M|FBLN1_ENST00000262722.7_Missense_Mutation_p.T56M|FBLN1_ENST00000442170.2_Missense_Mutation_p.T56M			P23142	FBLN1_HUMAN	fibulin 1	56	Anaphylatoxin-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCATATGCTACGGAATCCAAA	0.562													18	0					0	0	1	0	0	T	45914649	C	T	45914649	3	4	18	1	0	0	0	0	1	0	0	0	5730	536	19	1	173	1	FBLN1	22	45914649	Missense_Mutation	SNP	C	TCGA-N6-A4VE-01A-11D-A28R-08	4175075	45914649	5389917	76	1302										
CDKL5	6792	broad.mit.edu	37	chrX	18622158	18622158	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gcttcctaaatggaaaccttGctggagctagtcttagtcca	9	10	1	0			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chrX:18622158G>A	ENST00000379989.3	+	13	1399	c.1114G>A	c.(1114-1116)Gct>Act	p.A372T	CDKL5_ENST00000379996.3_Missense_Mutation_p.A372T|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	372					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					TGGAAACCTTGCTGGAGCTAG	0.522													44	168					0	0	1	0	0	A	18622158	G	A	18622158	3	1	18	1	0	0	0	0	1	0	0	0	3179	1319	46	3	1156	3	CDKL5	23	18622158	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08		18622158	136648402	77	1303										
HUWE1	10075	broad.mit.edu	37	chrX	53611281	53611281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	gagagtcagcatcacagggcGtcggttccctgtttcctcat	11	12	3	1			TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chrX:53611281G>A	ENST00000342160.3	-	40	5483	c.5026C>T	c.(5026-5028)Cgc>Tgc	p.R1676C	HUWE1_ENST00000218328.8_Intron|HUWE1_ENST00000262854.6_Missense_Mutation_p.R1676C			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1676	WWE.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ATCACAGGGCGTCGGTTCCCT	0.438													5	52					0	0	1	0	0	A	53611281	G	A	53611281	3	1	18	1	0	0	0	0	1	0	0	0	7504	1145	40	1	8274	1	HUWE1	23	53611281	Missense_Mutation	SNP	G	TCGA-N6-A4VE-01A-11D-A28R-08	34989123	53611281	101659279	78	1304										
GPRASP1	9737	broad.mit.edu	37	chrX	101912011	101912011	+	Frame_Shift_Del	DEL	G	G	-													0.0506329113924051	4	1	1.03543913713405	1.3142112125163	0.854237288135593	1	1	0	tcagttcaagcctggtccatGgggtagggtcggcttcccat							TCGA-N6-A4VE-01A-11D-A28R-08	TCGA-N6-A4VE-11A-12D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23e46a5d-8da7-43a0-b4a3-63dcc11fd071	aa58534e-57ed-44dd-be20-6f4a4ff1d11e	g.chrX:101912011delG	ENST00000537097.1	+	6	3983	c.3170delG	c.(3169-3171)tgfs	p.W1057fs	GPRASP1_ENST00000415986.1_Frame_Shift_Del_p.W1057fs|GPRASP1_ENST00000444152.1_Frame_Shift_Del_p.W1057fs|GPRASP1_ENST00000361600.5_Frame_Shift_Del_p.W1057fs|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	1057	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CCTGGTCCATGGGGTAGGGTC	0.517													104	135	---	---	---	---						-	101912011	G	-	101912011	7	5	18	1	0	1	0	1	0	0	0	0	6762	1357	47	0	3172	0	GPRASP1	23	101912011	Frame_Shift_Del	DEL	G	TCGA-N6-A4VE-01A-11D-A28R-08	48300730	101912011	53358549	79	1305										
AGRN	375790	broad.mit.edu	37	chr1	985167	985168	+	Frame_Shift_Ins	INS	-	-	C													0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cattgccagtgcccgcccggINSccgcgtcggtgagggtgggg							TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr1:985167_985168insC	ENST00000379370.2	+	26	4786_4787	c.4736_4737insC	c.(4735-4737)gcgfs	p.A1579fs		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1579	EGF-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TGCCCGCCCGGCCGCGTCGGTG	0.752													9	21	---	---	---	---						C	985168	-	C	985167	7	5	19	1	0	1	1	0	0	0	0	0	394	1203	42	0	4838	0	AGRN	1	985167	Frame_Shift_Ins	INS	-	TCGA-N6-A4VF-01A-31D-A28R-08		985167	248265454	1	1306										
CASZ1	54897	broad.mit.edu	37	chr1	10715751	10715751	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ttcccattgaggtggcagccGtggtagtagacgctgcagtc	14	10	0	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr1:10715751G>A	ENST00000377022.3	-	9	1937	c.1620C>T	c.(1618-1620)caC>caT	p.H540H	CASZ1_ENST00000344008.5_Silent_p.H540H	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGTGGCAGCCGTGGTAGTAGA	0.637													14	22					0	0	1	0	0	A	10715751	G	A	10715751	2	1	19	1	0	0	0	0	0	0	0	1	2703	1136	40	1		1	CASZ1	1	10715751	Silent	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	9730584	10715751	238534870	2	1307										
HSPG2	3339	broad.mit.edu	37	chr1	22161368	22161368	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	tcacccagtgccaggcattcGaactccacggcgtggccaac	10	16	1	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr1:22161368G>A	ENST00000374695.3	-	77	10603	c.10524C>T	c.(10522-10524)ttC>ttT	p.F3508F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3508	Ig-like C2-type 21.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCAGGCATTCGAACTCCACGG	0.637													25	49					0	0	1	0	0	A	22161368	G	A	22161368	2	1	19	1	0	0	0	0	0	0	0	1	7473	1049	37	1		1	HSPG2	1	22161368	Silent	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	11445617	22161368	227089253	3	1308										
LEPR	3953	broad.mit.edu	37	chr1	66081728	66081728	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ctcattgtgcagtgttcagaGatatgtgataaaccatcata	8	7	3	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr1:66081728G>A	ENST00000349533.6	+	15	2218	c.2033G>A	c.(2032-2034)aGa>aAa	p.R678K	LEPR_ENST00000371060.3_Missense_Mutation_p.R678K|LEPR_ENST00000344610.8_Missense_Mutation_p.R678K|LEPR_ENST00000371059.3_Missense_Mutation_p.R678K|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371058.1_Missense_Mutation_p.R678K	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	678	Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AGTGTTCAGAGATATGTGATA	0.393													23	44					0	0	1	0	0	A	66081728	G	A	66081728	3	1	19	1	0	0	0	0	1	0	0	0	8766	942	33	3	2083	3	LEPR	1	66081728	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	43920360	66081728	183168893	4	1309										
SEC22B	9554	broad.mit.edu	37	chr1	145115028	145115028	+	RNA	DEL	T	T	-													0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	aaaagcttaatttacttgcgTttttttttgtagtacttatt					rs139627460		TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr1:145115028delT	ENST00000453618.1	+	0	820							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TTTACTTGCGTTTTTTTTTGT	0.284													2	4	---	---	---	---						-	145115028	T	-	145115028	6	5	19	0	1	1	0	1	0	0	0	0	14042	1740	60	0		0	SEC22B	1	145115028	RNA	DEL	T	TCGA-N6-A4VF-01A-31D-A28R-08	79033300	145115028	104135593	5	1310										
KCNJ9	3765	broad.mit.edu	37	chr1	160054319	160054319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	agatctcgcagcccaacaagCgcgcagccacgctcgtcttc	9	17	2	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr1:160054319C>T	ENST00000368088.3	+	2	741	c.499C>T	c.(499-501)Cgc>Tgc	p.R167C		NM_004983.2	NP_004974.2	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 9	167					synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			biliary_tract(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(2)	16	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCCCAACAAGCGCGCAGCCAC	0.652													20	20					0	0	1	0	0	T	160054319	C	T	160054319	3	4	19	1	0	0	0	0	1	0	0	0	8100	768	27	1	501	1	KCNJ9	1	160054319	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	14939291	160054319	89196302	6	1311										
UGT1A6	0	broad.mit.edu	37	chr2	234601884	234601884	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	tactacacaagaaaaatctaTccagtgccgtatgaccaaga	6	10	1	3			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr2:234601884T>G	ENST00000305139.6	+	1	373	c.234T>G	c.(232-234)taT>taG	p.Y78*	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000344644.5_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		GAAAAATCTATCCAGTGCCGT	0.423													29	49					0	0	1	0	0	G	234601884	T	G	234601884	4	3	19	1	0	0	0	0	0	1	0	0	17008	1442	50	4	236	4	UGT1A6	2	234601884	Nonsense_Mutation	SNP	T	TCGA-N6-A4VF-01A-31D-A28R-08		234601884	8597489	7	1312										
ITIH4	3700	broad.mit.edu	37	chr3	52858518	52858518	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	agttgcttctgtactgaagaCgatgaggttgaactggtctc	12	7	2	4			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr3:52858518C>T	ENST00000266041.4	-	8	1036	c.940G>A	c.(940-942)Gtc>Atc	p.V314I	ITIH4-AS1_ENST00000478366.1_RNA|ITIH4_ENST00000406595.1_Missense_Mutation_p.V314I|ITIH4_ENST00000485816.1_Missense_Mutation_p.V314I|ITIH4_ENST00000434759.3_Missense_Mutation_p.V226I|ITIH4_ENST00000346281.5_Missense_Mutation_p.V314I	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	314	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GTACTGAAGACGATGAGGTTG	0.572													14	71					0	0	1	0	0	T	52858518	C	T	52858518	3	4	19	1	0	0	0	0	1	0	0	0	7949	536	19	1	1920	1	ITIH4	3	52858518	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		52858518	145163912	8	1313										
TMF1	7110	broad.mit.edu	37	chr3	69084233	69084237	+	Frame_Shift_Del	DEL	CTGTA	CTGTA	-													0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ctttctggcagccgcttgttCtgtacgctgcaatgcaagcc							TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr3:69084233_69084237delCTGTA	ENST00000543976.1	-	9	2436_2440	c.2190_2194delTACAG	c.(2188-2196)cgaafs	p.RTE730fs	CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000601735.1_RNA|CTD-2013N24.2_ENST00000601511.1_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|TMF1_ENST00000398559.2_Frame_Shift_Del_p.RTE727fs|CTD-2013N24.2_ENST00000599467.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1	727					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GCCGCTTGTTCTGTACGCTGCAATG	0.434													8	132	---	---	---	---						-	69084237	CTGTA	-	69084233	7	5	19	1	0	1	0	1	0	0	0	0	16287	922	32	0	1132	0	TMF1	3	69084233	Frame_Shift_Del	DEL	CTGTA	TCGA-N6-A4VF-01A-31D-A28R-08	16225715	69084233	128938197	9	1314										
EPHB1	2047	broad.mit.edu	37	chr3	134670597	134670597	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ggagctttgggcctcttactCggaatggtttttacctcgct	11	10	1	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr3:134670597C>T	ENST00000398015.3	+	3	878	c.508C>T	c.(508-510)Cgg>Tgg	p.R170W	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	170						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GCCTCTTACTCGGAATGGTTT	0.463													94	117					0	0	1	0	0	T	134670597	C	T	134670597	3	4	19	1	0	0	0	0	1	0	0	0	5202	875	31	1	518	1	EPHB1	3	134670597	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	65586364	134670597	63351833	10	1315										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	18					0	0	1	0	0	A	178936091	G	A	178936091	3	1	19	1	0	0	0	0	1	0	0	0	11960	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	44265494	178936091	19086339	11	1316										
PCDHA3	0	broad.mit.edu	37	chr5	140183011	140183011	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cccacgctggtgtgctccagCgcggtggggagctggtcata	16	12	1	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr5:140183011C>T	ENST00000522353.2	+	1	2229	c.2229C>T	c.(2227-2229)agC>agT	p.S743S	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Silent_p.S743S|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1												p.S743S(4)|p.S743R(2)		NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTCCAGCGCGGTGGGGA	0.637													52	106					0	0	1	0	0	T	140183011	C	T	140183011	2	4	19	1	0	0	0	0	0	0	0	1	11571	767	27	1		1	PCDHA3	5	140183011	Silent	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		140183011	40732249	12	1317										
PCDHGB3	0	broad.mit.edu	37	chr5	140751623	140751623	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ctgcgcgtgttggtggacgaCcgcaacgacaatgcaccgct	13	13	0	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr5:140751623C>T	ENST00000576222.1	+	1	1793	c.1662C>T	c.(1660-1662)gaC>gaT	p.D554D	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGACGACCGCAACGACA	0.667													21	55					0	0	1	0	0	T	140751623	C	T	140751623	2	4	19	1	0	0	0	0	0	0	0	1	11610	506	18	3		3	PCDHGB3	5	140751623	Silent	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	568612	140751623	40163637	13	1318										
BMP6	654	broad.mit.edu	37	chr6	7845380	7845380	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	tttaatcttatagtggagtaCgacaaggagttctcccctcg	9	9	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr6:7845380C>T	ENST00000283147.6	+	2	831	c.672C>T	c.(670-672)taC>taT	p.Y224Y		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	224					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					TAGTGGAGTACGACAAGGAGT	0.478													37	52					0	0	1	0	0	T	7845380	C	T	7845380	2	4	19	1	0	0	0	0	0	0	0	1	1463	547	19	1		1	BMP6	6	7845380	Silent	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		7845380	163269687	14	1319										
SOX4	6659	broad.mit.edu	37	chr6	21596141	21596141	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cgaggtgagcgagatgatctCgggagactggctcgagtcca	16	9	1	4			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr6:21596141C>G	ENST00000244745.1	+	1	2170	c.1376C>G	c.(1375-1377)tCg>tGg	p.S459W	SOX4_ENST00000543472.1_Missense_Mutation_p.S459W	NM_003107.2	NP_003098.1	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	459					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity			kidney(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	6	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			GAGATGATCTCGGGAGACTGG	0.622													4	16					0	0	1	0	0	G	21596141	C	G	21596141	3	3	19	1	0	0	0	0	1	0	0	0	15006	893	31	2	1378	2	SOX4	6	21596141	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	13750761	21596141	149518926	15	1320										
REV3L	5980	broad.mit.edu	37	chr6	111631214	111631214	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gcgccttacaagctggataaGtggtactccgggggtcccat	13	11	0	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr6:111631214G>A	ENST00000435970.1	-	32	9466	c.8650C>T	c.(8650-8652)Ctt>Ttt	p.L2884F	REV3L_ENST00000462119.1_5'UTR|RP5-1112D6.8_ENST00000607434.1_RNA|REV3L_ENST00000358835.3_Missense_Mutation_p.L2962F|REV3L_ENST00000368805.1_Missense_Mutation_p.L2962F|REV3L_ENST00000368802.3_Missense_Mutation_p.L2962F			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2962					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGCTGGATAAGTGGTACTCCG	0.512								DNA polymerases (catalytic subunits)					27	66					0	0	1	0	0	A	111631214	G	A	111631214	3	1	19	1	0	0	0	0	1	0	0	0	13291	1029	36	3	520	3	REV3L	6	111631214	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	90035073	111631214	59483853	16	1321										
SGK1	6446	broad.mit.edu	37	chr6	134491532	134491532	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gagttggggacaggctcttcGgtaaactcggggtcaaagtg	16	7	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr6:134491532G>C	ENST00000367858.5	-	14	2052	c.1455C>G	c.(1453-1455)acC>acG	p.T485T	SGK1_ENST00000413996.3_Silent_p.T404T|SGK1_ENST00000367857.5_Silent_p.T380T|SGK1_ENST00000528577.1_Silent_p.T418T|SGK1_ENST00000237305.7_Silent_p.T390T|SGK1_ENST00000475719.2_Silent_p.T346T	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	390					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		CAGGCTCTTCGGTAAACTCGG	0.557													36	55					0	0	1	0	0	C	134491532	G	C	134491532	2	2	19	1	0	0	0	0	0	0	0	1	14260	1103	39	5		5	SGK1	6	134491532	Silent	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	22860318	134491532	36623535	17	1322										
MAP7	9053	broad.mit.edu	37	chr6	136710584	136710584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ctcctccaacctcttcttccGctcttccaggtgcttctcgt	5	18	4	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr6:136710584G>A	ENST00000354570.3	-	4	726	c.316C>T	c.(316-318)Cgg>Tgg	p.R106W	MAP7_ENST00000544465.1_Missense_Mutation_p.R91W|MAP7_ENST00000454590.1_Missense_Mutation_p.R128W|MAP7_ENST00000438100.2_Missense_Mutation_p.R128W|MAP7_ENST00000432797.2_5'UTR	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	106					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CTCTTCTTCCGCTCTTCCAGG	0.527													43	77					0	0	1	0	0	A	136710584	G	A	136710584	3	1	19	1	0	0	0	0	1	0	0	0	9315	1086	38	1	1993	1	MAP7	6	136710584	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	2219052	136710584	34404483	18	1323										
CLIP2	7461	broad.mit.edu	37	chr7	73731941	73731941	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gcactccagccccatgggccGgacatctactgggtcagctt	11	15	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr7:73731941G>A	ENST00000223398.6	+	2	392	c.65G>A	c.(64-66)cGg>cAg	p.R22Q	CLIP2_ENST00000395060.1_Missense_Mutation_p.R22Q|CLIP2_ENST00000361545.5_Missense_Mutation_p.R22Q	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	22						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						CCCATGGGCCGGACATCTACT	0.672													75	100					0	0	1	0	0	A	73731941	G	A	73731941	3	1	19	1	0	0	0	0	1	0	0	0	3556	1116	39	1	67	1	CLIP2	7	73731941	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08		73731941	85406722	19	1324										
ZAN	7455	broad.mit.edu	37	chr7	100348502	100348502	+	RNA	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ccgtcaccgtcccctcaggaCaccaacagcccatgcaggtg	9	18	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr7:100348502C>T	ENST00000542585.1	+	0	1652				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCCTCAGGACACCAACAGCC	0.647													20	27					0	0	1	0	0	T	100348502	C	T	100348502	1	4	19	0	1	0	0	0	0	0	0	0	17572	478	17	3		3	ZAN	7	100348502	RNA	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	26616561	100348502	58790161	20	1325										
ZNF775	285971	broad.mit.edu	37	chr7	150094403	150094403	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cccgaggggccgggcgagccGcgccagttcatctgcaacga	15	15	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr7:150094403G>A	ENST00000329630.5	+	3	941	c.834G>A	c.(832-834)ccG>ccA	p.P278P		NM_173680.3	NP_775951.2	Q96BV0	ZN775_HUMAN	zinc finger protein 775	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(7)|skin(1)	11	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		cgggcgagccgcgccAGTTCA	0.741													14	25					0	0	1	0	0	A	150094403	G	A	150094403	2	1	19	1	0	0	0	0	0	0	0	1	18196	1074	38	1		1	ZNF775	7	150094403	Silent	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	49745901	150094403	9044260	21	1326										
SCRIB	23513	broad.mit.edu	37	chr8	144892705	144892705	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gcaagggcaggcctcgctccGccgcccctcgatgctcctct	11	19	1	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr8:144892705G>A	ENST00000356994.2	-	13	1480	c.1474C>T	c.(1474-1476)Cgg>Tgg	p.R492W	SCRIB_ENST00000320476.3_Missense_Mutation_p.R492W|SCRIB_ENST00000377533.3_Missense_Mutation_p.R411W	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	492	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCCTCGCTCCGCCGCCCCTCG	0.682													19	148					0	0	1	0	0	A	144892705	G	A	144892705	3	1	19	1	0	0	0	0	1	0	0	0	13990	1086	38	1	3593	1	SCRIB	8	144892705	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08		144892705	1471317	22	1327										
TMEM215	401498	broad.mit.edu	37	chr9	32784834	32784834	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gaacagcccgtatgacagatActgttgttatatcaatcaga	8	8	2	3			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr9:32784834A>G	ENST00000342743.5	+	2	1018	c.653A>G	c.(652-654)tAc>tGc	p.Y218C		NM_212558.2	NP_997723.2	Q68D42	TM215_HUMAN	transmembrane protein 215	218						integral to membrane				endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)	12						TATGACAGATACTGTTGTTAT	0.478													15	55					0	0	1	0	0	G	32784834	A	G	32784834	3	3	19	1	0	0	0	0	1	0	0	0	16197	391	14	4	655	4	TMEM215	9	32784834	Missense_Mutation	SNP	A	TCGA-N6-A4VF-01A-31D-A28R-08		32784834	108428597	23	1328										
PTEN	5728	broad.mit.edu	37	chr10	89692904	89692904	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	actgtaaagctggaaagggaCgaactggtgtaatgatatgt	13	4	0	1	rs121913292		TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr10:89692904C>G	ENST00000371953.3	+	5	1745	c.388C>G	c.(388-390)Cga>Gga	p.R130G		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).|R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(102)|p.R130*(63)|p.0?(37)|p.?(5)|p.R55fs*1(5)|p.K128_R130del(3)|p.Y27fs*1(2)|p.R130R(1)|p.A121_F145del(1)|p.R130fs*4(1)|p.G129fs*51(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.K128fs*47(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(KMBC2_URINARY_TRACT)|R130G(OV56_OVARY)	31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			29	36					0	0	1	0	0	G	89692904	C	G	89692904	3	3	19	1	0	0	0	0	1	0	0	0	12786	528	19	5	406	5	PTEN	10	89692904	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		89692904	45841843	24	1329										
PTPN5	84867	broad.mit.edu	37	chr11	18755102	18755102	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cgtcagggtgggaatacgtaCccggatgtagttggcattga	15	7	1	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:18755102C>T	ENST00000396170.1	-	10	2249		c.e10+1		RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000396168.1_Splice_Site|PTPN5_ENST00000396167.2_Splice_Site|PTPN5_ENST00000396171.4_Splice_Site|PTPN5_ENST00000477854.1_Splice_Site|PTPN5_ENST00000358540.2_Splice_Site	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)							integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						GGAATACGTACCCGGATGTAG	0.592													35	56					0	0	1	0	0	T	18755102	C	T	18755102	5	4	19	1	0	0	0	0	0	0	1	0	12842	521	18	3	640	3	PTPN5	11	18755102	Splice_Site	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		18755102	116251414	25	1330										
KCNA4	3739	broad.mit.edu	37	chr11	30034018	30034018	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	agggtcatgggaggtacaggCcccgcgtgactggtggtggt	19	8	1	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:30034018C>T	ENST00000328224.6	-	2	1441	c.208G>A	c.(208-210)Gcc>Acc	p.A70T		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	70						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GAGGTACAGGCCCCGCGTGAC	0.662													13	66					0	0	1	0	0	T	30034018	C	T	30034018	3	4	19	1	0	0	0	0	1	0	0	0	8048	739	26	3	1757	3	KCNA4	11	30034018	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	11278916	30034018	104972498	26	1331										
LRRC4C	57689	broad.mit.edu	37	chr11	40137424	40137424	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	agtatacaaaagctccattcGggatggtagtaagacgattg	11	6	0	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:40137424G>A	ENST00000278198.2	-	2	2382	c.419C>T	c.(418-420)cCg>cTg	p.P140L	LRRC4C_ENST00000530763.1_Missense_Mutation_p.P140L|LRRC4C_ENST00000528697.1_Missense_Mutation_p.P140L|LRRC4C_ENST00000527150.1_Missense_Mutation_p.P140L			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	140					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGCTCCATTCGGGATGGTAGT	0.423													12	29					0	0	1	0	0	A	40137424	G	A	40137424	3	1	19	1	0	0	0	0	1	0	0	0	9052	1116	39	1	1507	1	LRRC4C	11	40137424	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	10103406	40137424	94869092	27	1332										
MEN1	0	broad.mit.edu	37	chr11	64572230	64572230	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cccgggcttcctcgccccacGgctcctcggcctcggccgcc	11	23	0	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:64572230G>A	ENST00000337652.1	-	10	1927	c.1424C>T	c.(1423-1425)cCg>cTg	p.P475L	MEN1_ENST00000443283.1_Missense_Mutation_p.P475L|MEN1_ENST00000377321.1_Missense_Mutation_p.P435L|MEN1_ENST00000377313.1_Missense_Mutation_p.P475L|MEN1_ENST00000377316.2_Missense_Mutation_p.P415L|MEN1_ENST00000394374.2_Missense_Mutation_p.P475L|MEN1_ENST00000312049.6_Missense_Mutation_p.P470L|MEN1_ENST00000394376.1_Missense_Mutation_p.P475L|MEN1_ENST00000315422.4_Missense_Mutation_p.P470L|MEN1_ENST00000478548.1_5'UTR|MEN1_ENST00000377326.3_Missense_Mutation_p.P470L	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	475					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						CTCGCCCCACGGCTCCTCGGC	0.731			"D, Mis, N, F, S"		"parathyroid tumors, Pancreatic neuroendocrine tumors"	"parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				20	56					0	0	1	0	0	A	64572230	G	A	64572230	3	1	19	1	0	0	0	0	1	0	0	0	9521	1116	39	1	427	1	MEN1	11	64572230	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	24434806	64572230	70434286	28	1333										
MAML2	84441	broad.mit.edu	37	chr11	95718733	95718733	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gttgcatattgcccacatttCttctttggtctttataatct	5	9	4	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:95718733C>T	ENST00000524717.1	-	4	3701	c.2417G>A	c.(2416-2418)aGa>aAa	p.R806K		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	806					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				GCCCACATTTCTTCTTTGGTC	0.323			T	"MECT1, CRTC3"	salivary gland mucoepidermoid								5	15					0	0	1	0	0	T	95718733	C	T	95718733	3	4	19	1	0	0	0	0	1	0	0	0	9255	913	32	3	1061	3	MAML2	11	95718733	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	31146503	95718733	39287783	29	1334										
DSCAML1	57453	broad.mit.edu	37	chr11	117391968	117391968	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cgtctcgttgctgagcccgcGgatggagatggcctcgtcag	15	12	2	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:117391968G>A	ENST00000321322.6	-	6	1271	c.1270C>T	c.(1270-1272)Cgc>Tgc	p.R424C	DSCAML1_ENST00000527706.1_Missense_Mutation_p.R154C	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	364	Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTGAGCCCGCGGATGGAGATG	0.652													58	108					0	0	1	0	0	A	117391968	G	A	117391968	3	1	19	1	0	0	0	0	1	0	0	0	4795	1116	39	1	5183	1	DSCAML1	11	117391968	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	21673235	117391968	17614548	30	1335										
OR8A1	390275	broad.mit.edu	37	chr11	124440650	124440650	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	catcatagtcacgagcttaaCagttcttgtttcttacacct	5	11	4	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr11:124440650C>A	ENST00000284287.3	+	1	758	c.686C>A	c.(685-687)aCa>aAa	p.T229K		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		ACGAGCTTAACAGTTCTTGTT	0.498													20	42					1.56452e-12	1.63063e-12	1	1	0	A	124440650	C	A	124440650	3	1	19	1	0	0	0	0	1	0	0	0	11271	478	17	5	688	5	OR8A1	11	124440650	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	7048682	124440650	10565866	31	1336										
ZC3H10	84872	broad.mit.edu	37	chr12	56515410	56515410	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	tgctgctccaccacccccacCcccacacttgaccccagaga	5	22	0	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr12:56515410C>T	ENST00000257940.2	+	3	1340	c.1064C>T	c.(1063-1065)cCc>cTc	p.P355L	RP11-603J24.5_ENST00000549438.1_RNA|RP11-603J24.5_ENST00000550947.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	355	Pro-rich.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			CCACCCCCACCCCCACACTTG	0.627													25	46					0	0	1	0	0	T	56515410	C	T	56515410	3	4	19	1	0	0	0	0	1	0	0	0	17617	623	22	3	1066	3	ZC3H10	12	56515410	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		56515410	77336485	32	1337										
ARHGAP9	64333	broad.mit.edu	37	chr12	57871401	57871401	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gggggtggggaccgaggacaGcggcgaaggtccaccaggtt	20	9	0	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr12:57871401G>T	ENST00000393797.2	-	7	1002	c.810C>A	c.(808-810)cgC>cgA	p.R270R	ARHGAP9_ENST00000356411.2_Silent_p.R199R|ARHGAP9_ENST00000424809.2_Silent_p.R199R|ARHGAP9_ENST00000550454.1_5'UTR|ARHGAP9_ENST00000550288.1_Silent_p.R278R|ARHGAP9_ENST00000393791.3_Silent_p.R199R|ARHGAP9_ENST00000430041.2_Silent_p.R15R			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	199					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			ACCGAGGACAGCGGCGAAGGT	0.647													23	55					3.5997e-14	3.8054e-14	1	1	0	T	57871401	G	T	57871401	2	4	19	1	0	0	0	0	0	0	0	1	886	958	34	5		5	ARHGAP9	12	57871401	Silent	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	1355991	57871401	75980494	33	1338										
NAV3	89795	broad.mit.edu	37	chr12	78400511	78400511	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	caatgcccggactgctttacGccccccgcagcctcccagtt	8	19	0	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr12:78400511G>A	ENST00000397909.2	+	8	1366	c.1193G>A	c.(1192-1194)cGc>cAc	p.R398H	NAV3_ENST00000228327.6_Missense_Mutation_p.R398H|NAV3_ENST00000536525.2_Missense_Mutation_p.R398H|NAV3_ENST00000266692.7_Missense_Mutation_p.R398H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	398						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACTGCTTTACGCCCCCCGCAG	0.498										HNSCC(70;0.22)			38	59					0	0	1	0	0	A	78400511	G	A	78400511	3	1	19	1	0	0	0	0	1	0	0	0	10232	1087	38	1	1223	1	NAV3	12	78400511	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	20529110	78400511	55451384	34	1339										
RIC8B	55188	broad.mit.edu	37	chr12	107236410	107236410	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	atgttccagtctcttgtttgGatgttctcatttgtccgtta	8	8	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr12:107236410G>C	ENST00000392837.4	+	5	1031	c.880G>C	c.(880-882)Gat>Cat	p.D294H	RIC8B_ENST00000549643.1_Intron|RIC8B_ENST00000355478.2_Missense_Mutation_p.D254H|RIC8B_ENST00000392839.2_Missense_Mutation_p.D294H			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	294					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						CTCTTGTTTGGATGTTCTCAT	0.348													10	35					0	0	1	0	0	C	107236410	G	C	107236410	3	2	19	1	0	0	0	0	1	0	0	0	13405	1174	41	2	898	2	RIC8B	12	107236410	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	28835899	107236410	26615485	35	1340										
F10	2159	broad.mit.edu	37	chr13	113803456	113803456	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	acggggattgtgagcggcttCgggcgcacccacgagaaggg	18	10	0	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr13:113803456C>T	ENST00000375559.3	+	8	1130	c.1092C>T	c.(1090-1092)ttC>ttT	p.F364F	F10_ENST00000375551.3_3'UTR|F10_ENST00000409306.1_3'UTR	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	364	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAGCGGCTTCGGGCGCACCC	0.647													30	21					0	0	1	0	0	T	113803456	C	T	113803456	2	4	19	1	0	0	0	0	0	0	0	1	5364	883	31	1		1	F10	13	113803456	Silent	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		113803456	1366422	36	1341										
MBIP	51562	broad.mit.edu	37	chr14	36780847	36780847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cagcctgattaccacagtctCgaagcatgctgttaggttta	9	10	1	1	rs140089260		TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr14:36780847C>T	ENST00000416007.4	-	6	809	c.722G>A	c.(721-723)cGa>cAa	p.R241Q	MBIP_ENST00000318473.7_Missense_Mutation_p.R241Q|MBIP_ENST00000359527.7_Missense_Mutation_p.R241Q|MBIP_ENST00000603913.1_5'UTR	NM_001144891.1|NM_016586.2	NP_001138363.1|NP_057670.2	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1	241	Interaction with MAP3K12.				histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity			breast(2)|large_intestine(1)|lung(5)	8	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		ACCACAGTCTCGAAGCATGCT	0.428													11	25					0	0	1	0	0	T	36780847	C	T	36780847	3	4	19	1	0	0	0	0	1	0	0	0	9398	884	31	1	328	1	MBIP	14	36780847	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08		36780847	70568693	37	1342										
TRIP11	9321	broad.mit.edu	37	chr14	92472717	92472717	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ctttttttcatcatttagatCttgtttcagtttactgatga	5	6	4	3			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr14:92472717C>A	ENST00000267622.4	-	11	1976	c.1603G>T	c.(1603-1605)Gat>Tat	p.D535Y		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	535					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TCATTTAGATCTTGTTTCAGT	0.303			T	PDGFRB	AML								5	25					1.23904e-05	1.25601e-05	1	1	0	A	92472717	C	A	92472717	3	1	19	1	0	0	0	0	1	0	0	0	16615	913	32	2	4380	2	TRIP11	14	92472717	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	55691870	92472717	14876823	38	1343										
NTRK3	4916	broad.mit.edu	37	chr15	88679256	88679256	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gttgatggcatgaacattggTccagttcagattggtctgaa	12	6	2	4			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr15:88679256T>A	ENST00000394480.1	-	9	1102	c.781A>T	c.(781-783)Acc>Tcc	p.T261S	NTRK3_ENST00000557856.1_Missense_Mutation_p.T261S|NTRK3_ENST00000542733.2_Missense_Mutation_p.T163S|NTRK3_ENST00000355254.2_Missense_Mutation_p.T261S|NTRK3_ENST00000540489.2_Missense_Mutation_p.T261S|NTRK3_ENST00000317501.3_Missense_Mutation_p.T261S|NTRK3_ENST00000357724.2_Missense_Mutation_p.T261S|NTRK3_ENST00000360948.2_Missense_Mutation_p.T261S|NTRK3_ENST00000558676.1_Missense_Mutation_p.T261S	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	261	Ig-like C2-type 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGAACATTGGTCCAGTTCAGA	0.458			T	ETV6	"congenital fibrosarcoma, Secretory breast "					TSP Lung(13;0.10)			6	62					0	0	1	0	0	A	88679256	T	A	88679256	3	1	19	1	0	0	0	0	1	0	0	0	10755	1667	58	4	2048	4	NTRK3	15	88679256	Missense_Mutation	SNP	T	TCGA-N6-A4VF-01A-31D-A28R-08		88679256	13852136	39	1344										
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	14	13	3	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr17:7578394T>C	ENST00000420246.2	-	5	668	c.536A>G	c.(535-537)cAt>cGt	p.H179R	TP53_ENST00000413465.2_Missense_Mutation_p.H179R|TP53_ENST00000359597.4_Missense_Mutation_p.H179R|TP53_ENST00000445888.2_Missense_Mutation_p.H179R|TP53_ENST00000455263.2_Missense_Mutation_p.H179R|TP53_ENST00000269305.4_Missense_Mutation_p.H179R|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	179	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(108)|p.H179L(43)|p.P177_C182delPHHERC(8)|p.0?(8)|p.H47L(4)|p.H86L(4)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.H178_S183delHHERCS(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.H86R(2)|p.H47R(2)|p.R174fs*1(2)|p.H179fs*68(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H46_S51delHHERCS(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H85_S90delHHERCS(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	41					0	0	1	0	0	C	7578394	T	C	7578394	3	2	19	1	0	0	0	0	1	0	0	0	16441	1464	51	4	762	4	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-N6-A4VF-01A-31D-A28R-08		7578394	73616816	40	1345										
AZI1	22994	broad.mit.edu	37	chr17	79193819	79193819	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ggtccacacctgctgggctgCgctccgggacgctgccgatg	15	15	0	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr17:79193819C>T	ENST00000269392.4	-	2	285	c.38G>A	c.(37-39)cGc>cAc	p.R13H	AZI1_ENST00000450824.2_Missense_Mutation_p.R13H|AZI1_ENST00000374782.3_Missense_Mutation_p.R13H|AZI1_ENST00000575907.1_Missense_Mutation_p.R13H	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	13					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TGCTGGGCTGCGCTCCGGGAC	0.662													5	93					0	0	1	0	0	T	79193819	C	T	79193819	3	4	19	1	0	0	0	0	1	0	0	0	1238	768	27	1	3304	1	AZI1	17	79193819	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	71615425	79193819	2001391	41	1346										
EPB41L3	23136	broad.mit.edu	37	chr18	5428407	5428407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gtttattcgcagccggtcgcGatatatcaacagaccacttg	9	11	1	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr18:5428407G>A	ENST00000341928.2	-	9	1310	c.970C>T	c.(970-972)Cgc>Tgc	p.R324C	EPB41L3_ENST00000540638.2_Missense_Mutation_p.R324C|EPB41L3_ENST00000544123.1_Missense_Mutation_p.R324C|EPB41L3_ENST00000342933.3_Missense_Mutation_p.R324C|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000400111.3_Missense_Mutation_p.R324C	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	324	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						AGCCGGTCGCGATATATCAAC	0.413													38	89					0	0	1	0	0	A	5428407	G	A	5428407	3	1	19	1	0	0	0	0	1	0	0	0	5182	1058	37	1	2349	1	EPB41L3	18	5428407	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08		5428407	72648841	42	1347										
ASXL3	80816	broad.mit.edu	37	chr18	31324283	31324283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gtttgtctctgactgtctccGttgaaagctcagaagccagc	10	11	3	3			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr18:31324283G>A	ENST00000269197.5	+	12	4471	c.4471G>A	c.(4471-4473)Gtt>Att	p.V1491I		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GACTGTCTCCGTTGAAAGCTC	0.557											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	53					0	0	1	0	0	A	31324283	G	A	31324283	3	1	19	1	0	0	0	0	1	0	0	0	1067	1145	40	1	4517	1	ASXL3	18	31324283	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	25895876	31324283	46752965	43	1348										
SALL3	27164	broad.mit.edu	37	chr18	76754280	76754280	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cacatccgcatgcacatgggCggccagatccccaacacgcc	9	18	0	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr18:76754280C>T	ENST00000536229.3	+	1	2599	c.1890C>T	c.(1888-1890)ggC>ggT	p.G630G	SALL3_ENST00000537592.2_Silent_p.G763G|SALL3_ENST00000575389.2_Silent_p.G763G			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	763					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TGCACATGGGCGGCCAGATCC	0.652													24	40					0	0	1	0	0	T	76754280	C	T	76754280	2	4	19	1	0	0	0	0	0	0	0	1	13863	755	27	1		1	SALL3	18	76754280	Silent	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	45429997	76754280	1322968	44	1349										
ILF3	3609	broad.mit.edu	37	chr19	10781723	10781723	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ttccgtttatccaacacaagAggagctggaggcagtccaga	11	10	0	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr19:10781723A>T	ENST00000449870.1	+	3	394	c.77A>T	c.(76-78)gAg>gTg	p.E26V	ILF3_ENST00000420083.1_Missense_Mutation_p.E26V|ILF3_ENST00000318511.3_Missense_Mutation_p.E26V|ILF3_ENST00000407004.3_Missense_Mutation_p.E26V|ILF3_ENST00000592763.1_Missense_Mutation_p.E26V|ILF3_ENST00000589998.1_Missense_Mutation_p.E26V|ILF3_ENST00000250241.8_Missense_Mutation_p.E26V|ILF3_ENST00000590261.1_Missense_Mutation_p.E26V|ILF3_ENST00000588657.1_Missense_Mutation_p.E26V	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	26					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CCAACACAAGAGGAGCTGGAG	0.502													7	22					0	0	1	0	0	T	10781723	A	T	10781723	3	4	19	1	0	0	0	0	1	0	0	0	7755	304	11	4	83	4	ILF3	19	10781723	Missense_Mutation	SNP	A	TCGA-N6-A4VF-01A-31D-A28R-08		10781723	48347260	45	1350										
DMWD	1762	broad.mit.edu	37	chr19	46289096	46289098	+	In_Frame_Del	DEL	CCA	CCA	-													0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cactgccactgccgccactgCcaccccggctgatgttgccc							TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr19:46289096_46289098delCCA	ENST00000270223.6	-	3	1701_1703	c.1656_1658delTGG	c.(1654-1659)ggc>gg	p.GG552del	AC011530.4_ENST00000593999.1_In_Frame_Del_p.VA47del|DMWD_ENST00000377735.3_In_Frame_Del_p.GG552del	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	552					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		GCCGCCACTGCCACCCCGGCTGA	0.719													28	37	---	---	---	---						-	46289098	CCA	-	46289096	7	5	19	1	0	1	0	1	0	0	0	0	4621	739	26	0	378	0	DMWD	19	46289096	In_Frame_Del	DEL	CCA	TCGA-N6-A4VF-01A-31D-A28R-08	35507373	46289096	12839887	46	1351										
FTL	2512	broad.mit.edu	37	chr19	49469955	49469955	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cccggaggctgggctgggcgAgtatctcttcgaaaggctca	15	11	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr19:49469955A>C	ENST00000331825.6	+	4	698	c.491A>C	c.(490-492)gAg>gCg	p.E164A		NM_000146.3	NP_000137.2	P02792	FRIL_HUMAN	ferritin, light polypeptide	164					cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity			cervix(1)|kidney(3)|lung(5)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	GGGCTGGGCGAGTATCTCTTC	0.552													9	83					0	0	1	0	0	C	49469955	A	C	49469955	3	2	19	1	0	0	0	0	1	0	0	0	6118	304	11	4	505	4	FTL	19	49469955	Missense_Mutation	SNP	A	TCGA-N6-A4VF-01A-31D-A28R-08	3180859	49469955	9659028	47	1352										
LRRN4	164312	broad.mit.edu	37	chr20	6022239	6022239	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	gggtctgcaggtgcttgcagGgatggtaatcacaggggacg	18	7	2	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr20:6022239G>A	ENST00000378858.4	-	5	1876	c.1652C>T	c.(1651-1653)cCc>cTc	p.P551L		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	551						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						GTGCTTGCAGGGATGGTAATC	0.662													46	136					0	0	1	0	0	A	6022239	G	A	6022239	3	1	19	1	0	0	0	0	1	0	0	0	9081	1232	43	3	574	3	LRRN4	20	6022239	Missense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08		6022239	57003281	48	1353										
HM13	81502	broad.mit.edu	37	chr20	30155955	30155955	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	cacagtctcgggctccccagCcagcctggccgactccatgc	10	19	1	0			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr20:30155955C>G	ENST00000335574.5	+	12	1233	c.1109C>G	c.(1108-1110)gCc>gGc	p.A370G	HM13_ENST00000398174.3_Missense_Mutation_p.A370G|HM13_ENST00000492709.1_Intron|HM13_ENST00000340852.5_Intron|HM13_ENST00000376127.3_Intron|HM13-AS1_ENST00000412178.1_RNA	NM_178580.1	NP_848695.1	Q8TCT9	HM13_HUMAN	histocompatibility (minor) 13	366					membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GGCTCCCCAGCCAGCCTGGCC	0.662													4	37					0	0	1	0	0	G	30155955	C	G	30155955	3	3	19	1	0	0	0	0	1	0	0	0	7257	739	26	5	1222	5	HM13	20	30155955	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	24133716	30155955	32869565	49	1354										
MYH7B	57644	broad.mit.edu	37	chr20	33572744	33572744	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	tgaggaatgataactcctccCgctttgtgagtggctgaggt	13	8	0	4			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr20:33572744C>T	ENST00000262873.7	+	10	954	c.862C>T	c.(862-864)Cgc>Tgc	p.R288C		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	246	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TAACTCCTCCCGCTTTGTGAG	0.652													31	65					0	0	1	0	0	T	33572744	C	T	33572744	3	4	19	1	0	0	0	0	1	0	0	0	10087	652	23	1	900	1	MYH7B	20	33572744	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	3416789	33572744	29452776	50	1355										
BAGE2	85319	broad.mit.edu	37	chr21	11071214	11071215	+	RNA	INS	-	-	C													0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	agagagagggcagaccaattINSagggcttcaggtgccaagaa					rs113940337		TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chr21:11071214_11071215insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gcagaccaattagggcttcagg	0.406													4	3	---	---	---	---						C	11071215	-	C	11071214	6	5	19	0	1	1	1	0	0	0	0	0	1290	1769	61	0		0	BAGE2	21	11071214	RNA	INS	-	TCGA-N6-A4VF-01A-31D-A28R-08		11071214	37058681	51	1356										
OPHN1	4983	broad.mit.edu	37	chrX	67433758	67433758	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	acttcctggatttgataaacAtaatcaagagaggactcgaa	8	7	1	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chrX:67433758A>C	ENST00000355520.5	-	7	1184	c.543T>G	c.(541-543)taT>taG	p.Y181*	OPHN1_ENST00000540071.1_Nonsense_Mutation_p.Y181*	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	181					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						TTTGATAAACATAATCAAGAG	0.363													3	5					0	0	1	0	0	C	67433758	A	C	67433758	4	2	19	1	0	0	0	0	0	1	0	0	10922	224	8	4	1937	4	OPHN1	23	67433758	Nonsense_Mutation	SNP	A	TCGA-N6-A4VF-01A-31D-A28R-08		67433758	87836802	52	1357										
NAP1L2	4674	broad.mit.edu	37	chrX	72433664	72433666	+	In_Frame_Del	DEL	TCC	TCC	-													0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ctccagtagcctcaatgtcgTcctcctcctcctcctcctcc							TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chrX:72433664_72433666delTCC	ENST00000373517.3	-	1	1018_1020	c.663_665delGGA	c.(661-666)gac>ga	p.ED221del	NAP1L2_ENST00000536638.1_In_Frame_Del_p.ED79del	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	221	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					CTCAATGTCGtcctcctcctcct	0.424													8	45	---	---	---	---						-	72433666	TCC	-	72433664	7	5	19	1	0	1	0	1	0	0	0	0	10204	1667	58	0	721	0	NAP1L2	23	72433664	In_Frame_Del	DEL	TCC	TCGA-N6-A4VF-01A-31D-A28R-08	4999906	72433664	82836896	53	1358										
ESX1	80712	broad.mit.edu	37	chrX	103498922	103498922	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	tgaacgcggtgcggcggcggCgtttcctctctgggggctgt	18	11	1	1			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chrX:103498922C>T	ENST00000372588.4	-	2	502	c.419G>A	c.(418-420)cGc>cAc	p.R140H		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	140					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GCGGCGGCGGCGTTTCCTCTC	0.632													21	75					0	0	1	0	0	T	103498922	C	T	103498922	3	4	19	1	0	0	0	0	1	0	0	0	5291	768	27	1	813	1	ESX1	23	103498922	Missense_Mutation	SNP	C	TCGA-N6-A4VF-01A-31D-A28R-08	31065258	103498922	51771638	54	1359										
GRIA3	2892	broad.mit.edu	37	chrX	122599593	122599593	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0545454545454545	3	1	0.680708180708181	0	0.780812324929972	0.142857142857143	0.651583710407241	0	ggacaaattgaaaaacaaatGgtggtacgacaaaggagagt	12	4	0	2			TCGA-N6-A4VF-01A-31D-A28R-08	TCGA-N6-A4VF-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc7bface-208b-486a-b554-868c2c150a47	e2d2cb02-4f0d-4b59-b69e-20d52775f899	g.chrX:122599593G>A	ENST00000264357.5	+	14	2685	c.2393G>A	c.(2392-2394)tGg>tAg	p.W798*	GRIA3_ENST00000371251.1_Nonsense_Mutation_p.W798*|GRIA3_ENST00000371256.5_Intron|GRIA3_ENST00000542149.1_Nonsense_Mutation_p.W798*	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	798					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	AAAAACAAATGGTGGTACGAC	0.458													16	36					0	0	1	0	0	A	122599593	G	A	122599593	4	1	19	1	0	0	0	0	0	1	0	0	6809	1357	47	3	2447	3	GRIA3	23	122599593	Nonsense_Mutation	SNP	G	TCGA-N6-A4VF-01A-31D-A28R-08	19100671	122599593	32670967	55	1360										
CDK11A	728642	broad.mit.edu	37	chr1	1650881	1650881	+	Missense_Mutation	SNP	C	C	G													0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tggtttgatggccaaagaatCatcttcttctcctctgaaat							TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr1:1650881C>G	ENST00000356200.3	-	3	373	c.139G>C	c.(139-141)Gat>Cat	p.D47H	CDK11A_ENST00000358779.5_Missense_Mutation_p.D81H|CDK11A_ENST00000357760.2_Missense_Mutation_p.D81H|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378633.1_Missense_Mutation_p.D81H|CDK11A_ENST00000378638.2_Missense_Mutation_p.D47H|CDK11A_ENST00000404249.3_Missense_Mutation_p.D81H|CDK11A_ENST00000378635.3_Missense_Mutation_p.D81H					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						GCCAAAGAATCATCTTCTTCT	0.393													35	183					0	0	1	0	0	G	1650881	C	G	1650881	3	3	20	1	0	0	0	0	1	0	0	0	3148	826	29	2	2169	2	CDK11A	1	1650881	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		1650881	247599740	1	1361	8	2								
CDK11A	728642	broad.mit.edu	37	chr1	1650883	1650883	+	Missense_Mutation	SNP	T	T	C													0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gtttgatggccaaagaatcaTcttcttctcctctgaaataa							TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr1:1650883T>C	ENST00000356200.3	-	3	371	c.137A>G	c.(136-138)gAt>gGt	p.D46G	CDK11A_ENST00000358779.5_Missense_Mutation_p.D80G|CDK11A_ENST00000357760.2_Missense_Mutation_p.D80G|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378633.1_Missense_Mutation_p.D80G|CDK11A_ENST00000378638.2_Missense_Mutation_p.D46G|CDK11A_ENST00000404249.3_Missense_Mutation_p.D80G|CDK11A_ENST00000378635.3_Missense_Mutation_p.D80G					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						CAAAGAATCATCTTCTTCTCC	0.388													35	185					0	0	1	0	0	C	1650883	T	C	1650883	3	2	20	1	0	0	0	0	1	0	0	0	3148	1435	50	4	2171	4	CDK11A	1	1650883	Missense_Mutation	SNP	T	TCGA-N6-A4VG-01A-31D-A28R-08	2	1650883	247599738	2	1362	8	2								
CSMD2	114784	broad.mit.edu	37	chr1	34192255	34192255	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	cccggagagaggatggtgccGctgggcgaagtcaggtgacc	18	10	1	2	rs145279639		TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr1:34192255G>A	ENST00000373381.4	-	16	2576	c.2400C>T	c.(2398-2400)agC>agT	p.S800S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	760	CUB 5.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGATGGTGCCGCTGGGCGAAG	0.562													24	26					0	0	1	0	0	A	34192255	G	A	34192255	2	1	20	1	0	0	0	0	0	0	0	1	3970	1078	38	1		1	CSMD2	1	34192255	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	32541372	34192255	215058366	3	1363										
ZBTB7B	51043	broad.mit.edu	37	chr1	154987459	154987459	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	cctccttgaatttgcctataCagccacactgaccaccagca	5	16	0	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr1:154987459C>A	ENST00000368426.3	+	3	460	c.323C>A	c.(322-324)aCa>aAa	p.T108K	ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.T142K|ZBTB7B_ENST00000292176.2_Missense_Mutation_p.T108K|ZBTB7B_ENST00000535420.1_Missense_Mutation_p.T108K	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	108	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTTGCCTATACAGCCACACTG	0.632													19	56					6.49762e-13	7.28521e-13	1	1	0	A	154987459	C	A	154987459	3	1	20	1	0	0	0	0	1	0	0	0	17612	478	17	5	325	5	ZBTB7B	1	154987459	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	120795204	154987459	94263162	4	1364										
OR10Z1	128368	broad.mit.edu	37	chr1	158576290	158576290	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	cctgggcttctccagttctgGggagttgcagctccttctct	11	13	3	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr1:158576290G>C	ENST00000361284.1	+	1	62	c.62G>C	c.(61-63)gGg>gCg	p.G21A		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TCCAGTTCTGGGGAGTTGCAG	0.473													16	120					0	0	1	0	0	C	158576290	G	C	158576290	3	2	20	1	0	0	0	0	1	0	0	0	10970	1232	43	5	64	5	OR10Z1	1	158576290	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	3588831	158576290	90674331	5	1365										
GALNT2	2590	broad.mit.edu	37	chr1	230203056	230203056	+	Frame_Shift_Del	DEL	G	G	-													0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gcgctcgcggatgctgctctGcttcgccttcctgtgggtgc							TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr1:230203056delG	ENST00000366672.4	+	1	101	c.29delG	c.(28-30)tcfs	p.C10fs	GALNT2_ENST00000543760.1_Intron|GALNT2_ENST00000541865.1_5'UTR	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	10					immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ATGCTGCTCTGCTTCGCCTTC	0.771													2	4	---	---	---	---						-	230203056	G	-	230203056	7	5	20	1	0	1	0	1	0	0	0	0	6252	1319	46	0	31	0	GALNT2	1	230203056	Frame_Shift_Del	DEL	G	TCGA-N6-A4VG-01A-31D-A28R-08	71626766	230203056	19047565	6	1366										
RIF1	55183	broad.mit.edu	37	chr2	152321302	152321302	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	aagaatacagaaaataatgaCgtagagattagtgaaacaaa	8	3	0	5			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr2:152321302C>T	ENST00000243326.4	+	29	5751	c.5268C>T	c.(5266-5268)gaC>gaT	p.D1756D	RIF1_ENST00000430328.2_Silent_p.D1756D|RIF1_ENST00000444746.2_Silent_p.D1756D|RIF1_ENST00000428287.2_Silent_p.D1756D|RIF1_ENST00000453091.2_Silent_p.D1756D			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1756					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AAAATAATGACGTAGAGATTA	0.393													10	36					0	0	1	0	0	T	152321302	C	T	152321302	2	4	20	1	0	0	0	0	0	0	0	1	13408	535	19	1		1	RIF1	2	152321302	Silent	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		152321302	90878071	7	1367										
NGEF	25791	broad.mit.edu	37	chr2	233785144	233785144	+	Frame_Shift_Del	DEL	C	C	-													0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ctctctggtgggctggccggCtcctcctcctcctcctcttc							TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr2:233785144delC	ENST00000264051.3	-	5	956	c.678delG	c.(676-678)gafs	p.E226fs	NGEF_ENST00000373552.4_Frame_Shift_Del_p.E134fs|NGEF_ENST00000409079.1_Frame_Shift_Del_p.E134fs	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	226	Poly-Glu.|Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGCTGGCCGGctcctcctcct	0.592													32	36	---	---	---	---						-	233785144	C	-	233785144	7	5	20	1	0	1	0	1	0	0	0	0	10440	796	28	0	1498	0	NGEF	2	233785144	Frame_Shift_Del	DEL	C	TCGA-N6-A4VG-01A-31D-A28R-08	81463842	233785144	9414229	8	1368										
UGT1A7	0	broad.mit.edu	37	chr2	234590591	234590591	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ctgaagttctctgatggctcGtgcagggtggactggcctcc	14	11	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr2:234590591G>A	ENST00000373426.3	+	1	8	c.8G>A	c.(7-9)cGt>cAt	p.R3H	UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CTGATGGCTCGTGCAGGGTGG	0.527											OREG0003832	type=REGULATORY REGION|Gene=UGT1A7|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	52	51					0	0	1	0	0	A	234590591	G	A	234590591	3	1	20	1	0	0	0	0	1	0	0	0	17009	1145	40	1	10	1	UGT1A7	2	234590591	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	805447	234590591	8608782	9	1369										
FARP2	9855	broad.mit.edu	37	chr2	242380727	242380727	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tttggttcccagagcatctcAttccccgagggattgaggac	11	11	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr2:242380727A>C	ENST00000264042.3	+	13	1337	c.1167A>C	c.(1165-1167)tcA>tcC	p.S389S	FARP2_ENST00000373287.4_Silent_p.S389S|FARP2_ENST00000545004.1_Silent_p.S389S	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	389					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		AGAGCATCTCATTCCCCGAGG	0.478													24	32					0	0	1	0	0	C	242380727	A	C	242380727	2	2	20	1	0	0	0	0	0	0	0	1	5709	204	8	4		4	FARP2	2	242380727	Silent	SNP	A	TCGA-N6-A4VG-01A-31D-A28R-08	7790136	242380727	818646	10	1370										
BRPF1	7862	broad.mit.edu	37	chr3	9781123	9781123	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	caagcagacagatgacgggcGctgggcccatgtggtgtgtg	17	9	0	3	rs149733062		TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr3:9781123G>T	ENST00000383829.2	+	3	1444	c.1040G>T	c.(1039-1041)cGc>cTc	p.R347L	BRPF1_ENST00000433861.2_Missense_Mutation_p.R347L|BRPF1_ENST00000457855.1_Missense_Mutation_p.R347L|BRPF1_ENST00000424362.1_Missense_Mutation_p.R347L|BRPF1_ENST00000302054.3_Missense_Mutation_p.R347L	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	347					histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					GATGACGGGCGCTGGGCCCAT	0.607													7	220					0.00198382	0.00203892	1	1	0	T	9781123	G	T	9781123	3	4	20	1	0	0	0	0	1	0	0	0	1522	1087	38	5	1046	5	BRPF1	3	9781123	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08		9781123	188241307	11	1371										
MYRIP	25924	broad.mit.edu	37	chr3	40251350	40251350	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ctggctttcatttaggtgtcGgatgatttatcagagacaga	11	6	2	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr3:40251350G>A	ENST00000302541.6	+	11	2013	c.1671G>A	c.(1669-1671)tcG>tcA	p.S557S	MYRIP_ENST00000444716.1_Silent_p.S557S|MYRIP_ENST00000396217.3_Silent_p.S468S|MYRIP_ENST00000425621.1_Silent_p.S557S|MYRIP_ENST00000539167.1_Silent_p.S370S|MYRIP_ENST00000459828.1_3'UTR	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	557	Actin-binding.|Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TTTAGGTGTCGGATGATTTAT	0.483													30	64					0	0	1	0	0	A	40251350	G	A	40251350	2	1	20	1	0	0	0	0	0	0	0	1	10147	1103	39	1		1	MYRIP	3	40251350	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	30470227	40251350	157771080	12	1372										
HYAL2	8692	broad.mit.edu	37	chr3	50355733	50355733	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tgtctgcaggtggtcaatgtCggcccaactgagctccccca	11	14	2	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr3:50355733C>T	ENST00000447092.1	-	3	3541	c.1249G>A	c.(1249-1251)Gac>Aac	p.D417N	HYAL2_ENST00000442581.1_Missense_Mutation_p.D417N|HYAL2_ENST00000395139.3_Missense_Mutation_p.D417N|HYAL2_ENST00000357750.4_Missense_Mutation_p.D417N			Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2	417	EGF-like.					anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			breast(1)|endometrium(2)|kidney(1)|ovary(1)|prostate(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	TGGTCAATGTCGGCCCAACTG	0.612													5	50					0	0	1	0	0	T	50355733	C	T	50355733	3	4	20	1	0	0	0	0	1	0	0	0	7507	884	31	1	176	1	HYAL2	3	50355733	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	10104383	50355733	147666697	13	1373										
FXR1	0	broad.mit.edu	37	chr3	180688077	180688077	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ggtctcgtagacgaaggactGatgaagatgctgttctgatg	14	6	2	5			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr3:180688077G>A	ENST00000357559.4	+	15	1918	c.1534G>A	c.(1534-1536)Gat>Aat	p.D512N	FXR1_ENST00000468861.1_Missense_Mutation_p.D427N|FXR1_ENST00000305586.7_Missense_Mutation_p.D427N|FXR1_ENST00000480918.1_Missense_Mutation_p.D499N|FXR1_ENST00000491062.1_Missense_Mutation_p.D463N|FXR1_ENST00000445140.2_Missense_Mutation_p.D512N	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	512					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			ACGAAGGACTGATGAAGATGC	0.423													19	41					0	0	1	0	0	A	180688077	G	A	180688077	3	1	20	1	0	0	0	0	1	0	0	0	6149	1290	45	3	1592	3	FXR1	3	180688077	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	130332344	180688077	17334353	14	1374										
SCLT1	132320	broad.mit.edu	37	chr4	129886450	129886450	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tctgatgcttcctctcttccAtgggcagacaccacatcctt	6	15	2	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr4:129886450A>T	ENST00000281142.5	-	11	1304	c.801T>A	c.(799-801)caT>caA	p.H267Q	SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000503215.1_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	267						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						CCTCTCTTCCATGGGCAGACA	0.343													13	26					0	0	1	0	0	T	129886450	A	T	129886450	3	4	20	1	0	0	0	0	1	0	0	0	13959	214	8	4	1309	4	SCLT1	4	129886450	Missense_Mutation	SNP	A	TCGA-N6-A4VG-01A-31D-A28R-08		129886450	61267826	15	1375										
SLC10A7	84068	broad.mit.edu	37	chr4	147204390	147204390	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	cagaaaatgatagccactgtGtctgctggtgtgaaacccga	11	9	1	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr4:147204390G>A	ENST00000432059.2	-	9	1008	c.762C>T	c.(760-762)gaC>gaT	p.D254D	SLC10A7_ENST00000335472.7_Silent_p.D267D|SLC10A7_ENST00000264986.3_3'UTR|SLC10A7_ENST00000507030.1_Silent_p.D267D|SLC10A7_ENST00000394062.3_Silent_p.D267D			Q0GE19	NTCP7_HUMAN	solute carrier family 10, member 7	267						integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|skin(1)	16	all_hematologic(180;0.151)					TAGCCACTGTGTCTGCTGGTG	0.338													9	7					0	0	1	0	0	A	147204390	G	A	147204390	2	1	20	1	0	0	0	0	0	0	0	1	14433	1368	48	3		3	SLC10A7	4	147204390	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	17317940	147204390	43949886	16	1376										
FBXW7	0	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gccatcatattgaacacagcGgactgctgcaacatgaccca	8	13	1	2	rs149680468		TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr4:153247289G>C	ENST00000281708.4	-	10	2742	c.1513C>G	c.(1513-1515)Cgc>Ggc	p.R505G	FBXW7_ENST00000603548.1_Missense_Mutation_p.R505G|FBXW7_ENST00000263981.5_Missense_Mutation_p.R425G|FBXW7_ENST00000296555.5_Missense_Mutation_p.R387G|FBXW7_ENST00000603841.1_Missense_Mutation_p.R505G|FBXW7_ENST00000393956.3_Missense_Mutation_p.R329G	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	505			R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R505C(60)|p.R505G(18)|p.R425C(14)|p.R266C(13)|p.R425G(9)|p.R266G(9)|p.R387G(6)|p.R387C(3)|p.R505S(3)|p.R387S(1)|p.?(1)|p.R425S(1)|p.R266S(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								49	33					0	0	1	0	0	C	153247289	G	C	153247289	3	2	20	1	0	0	0	0	1	0	0	0	5801	1116	39	5	622	5	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	6042899	153247289	37906987	17	1377										
SEMA5A	9037	broad.mit.edu	37	chr5	9043072	9043072	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gaataggtcttcccagtgagAtgtgggttgaagtatttgtt	13	4	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr5:9043072A>G	ENST00000382496.5	-	23	3827	c.3162T>C	c.(3160-3162)caT>caC	p.H1054H	CTD-2215L10.1_ENST00000506519.1_RNA	NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	1054					cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TCCCAGTGAGATGTGGGTTGA	0.333													27	28					0	0	1	0	0	G	9043072	A	G	9043072	2	3	20	1	0	0	0	0	0	0	0	1	14090	330	12	4		4	SEMA5A	5	9043072	Silent	SNP	A	TCGA-N6-A4VG-01A-31D-A28R-08		9043072	171872188	18	1378										
ADAMTS12	81792	broad.mit.edu	37	chr5	33658404	33658404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gtgagacaggcccagggtctCgcaggggcgattgaaaccag	16	10	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr5:33658404C>T	ENST00000504830.1	-	7	1410	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E359K	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	359	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CCCAGGGTCTCGCAGGGGCGA	0.498										HNSCC(64;0.19)			19	124					0	0	1	0	0	T	33658404	C	T	33658404	3	4	20	1	0	0	0	0	1	0	0	0	256	893	31	1	3781	1	ADAMTS12	5	33658404	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	24615332	33658404	147256856	19	1379										
PARP8	79668	broad.mit.edu	37	chr5	50045994	50045994	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tgttttaacagtgtatcctaCtcagtacatgtatctgaaga	7	7	2	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr5:50045994C>A	ENST00000281631.5	+	3	314	c.156C>A	c.(154-156)taC>taA	p.Y52*	PARP8_ENST00000505554.1_Nonsense_Mutation_p.Y31*|PARP8_ENST00000503750.2_Nonsense_Mutation_p.Y52*|PARP8_ENST00000514067.2_Nonsense_Mutation_p.Y52*|PARP8_ENST00000505697.2_Nonsense_Mutation_p.Y52*|PARP8_ENST00000514342.2_5'UTR|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	52						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				GTGTATCCTACTCAGTACATG	0.333													5	2					0.000602214	0.000645853	1	1	0	A	50045994	C	A	50045994	4	1	20	1	0	0	0	0	0	1	0	0	11511	576	20	5	166	5	PARP8	5	50045994	Nonsense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	16387590	50045994	130869266	20	1380										
RAPGEF6	51735	broad.mit.edu	37	chr5	130764852	130764852	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	aaatccccaaatatcctggaGgagtgggaggtggctcccta	12	10	0	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr5:130764852G>T	ENST00000509018.1	-	27	4728	c.4523C>A	c.(4522-4524)cCt>cAt	p.P1508H	RAPGEF6_ENST00000296859.6_Missense_Mutation_p.P1516H|RAPGEF6_ENST00000507093.1_Intron|RAPGEF6_ENST00000307984.5_Intron|FNIP1_ENST00000514667.1_Missense_Mutation_p.P1558H	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	1508					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ATATCCTGGAGGAGTGGGAGG	0.448													73	7					1.43675e-24	1.71484e-24	1	1	0	T	130764852	G	T	130764852	3	4	20	1	0	0	0	0	1	0	0	0	13099	1000	35	5	290	5	RAPGEF6	5	130764852	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	80718858	130764852	50150408	21	1381										
GMDS	2762	broad.mit.edu	37	chr6	1961068	1961068	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gggtatttcctgcactttccCataaagttcacttgttgagg	9	9	1	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr6:1961068C>G	ENST00000380815.4	-	5	747	c.478G>C	c.(478-480)Ggg>Cgg	p.G160R	GMDS_ENST00000530927.1_Missense_Mutation_p.G130R	NM_001500.3	NP_001491.1	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	160					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity		GMDS/PDE8B(2)	breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|prostate(1)	21	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TGCACTTTCCCATAAAGTTCA	0.502													28	66					0	0	1	0	0	G	1961068	C	G	1961068	3	3	20	1	0	0	0	0	1	0	0	0	6527	594	21	5	668	5	GMDS	6	1961068	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		1961068	169153999	22	1382										
KLHDC3	116138	broad.mit.edu	37	chr6	42986290	42986290	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gaggggcgccggagccactcGgcctgtgagtgtttgttact	16	10	0	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr6:42986290G>C	ENST00000326974.4	+	6	924	c.729G>C	c.(727-729)tcG>tcC	p.S243S	KLHDC3_ENST00000332245.8_Silent_p.S184S|KLHDC3_ENST00000244670.8_Silent_p.S109S	NM_057161.3	NP_476502.1	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	243					reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGAGCCACTCGGCCTGTGAGT	0.572													33	198					0	0	1	0	0	C	42986290	G	C	42986290	2	2	20	1	0	0	0	0	0	0	0	1	8399	1103	39	5		5	KLHDC3	6	42986290	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	41025222	42986290	128128777	23	1383										
PRDM1	639	broad.mit.edu	37	chr6	106553302	106553302	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ccccctacggcatgaattgtAatggcctgagcgctgtgagc	12	12	0	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr6:106553302A>C	ENST00000369096.4	+	5	1501	c.1267A>C	c.(1267-1269)Aat>Cat	p.N423H	PRDM1_ENST00000369089.3_Missense_Mutation_p.N289H|PRDM1_ENST00000369091.2_Missense_Mutation_p.N387H	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	423					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CATGAATTGTAATGGCCTGAG	0.602			"D, N, Mis, F, S"		DLBCL								80	431					0	0	1	0	0	C	106553302	A	C	106553302	3	2	20	1	0	0	0	0	1	0	0	0	12501	362	13	4	1298	4	PRDM1	6	106553302	Missense_Mutation	SNP	A	TCGA-N6-A4VG-01A-31D-A28R-08	63567012	106553302	64561765	24	1384										
DNAH11	8701	broad.mit.edu	37	chr7	21940750	21940750	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	aagaaaccaaacagacctacGagtgccctgtgtatagaacc	8	11	0	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr7:21940750G>A	ENST00000328843.6	+	83	13481	c.13450G>A	c.(13450-13452)Gag>Aag	p.E4484K	CDCA7L_ENST00000356195.5_3'UTR|CDCA7L_ENST00000406877.3_3'UTR|DNAH11_ENST00000409508.3_Missense_Mutation_p.E4477K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4484					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACAGACCTACGAGTGCCCTGT	0.527									Kartagener syndrome				48	59					0	0	1	0	0	A	21940750	G	A	21940750	3	1	20	1	0	0	0	0	1	0	0	0	4627	1059	37	1	13777	1	DNAH11	7	21940750	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08		21940750	137197913	25	1385										
GPR37	2861	broad.mit.edu	37	chr7	124386910	124386910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	agatattttcaggaataatgCaaaatccatataaaatggtc	6	5	1	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr7:124386910C>T	ENST00000303921.2	-	2	2161	c.1511G>A	c.(1510-1512)tGc>tAc	p.C504Y		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	504				FC -> LG (in Ref. 3; AAC51281).		endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						AGGAATAATGCAAAATCCATA	0.423													25	38					0	0	1	0	0	T	124386910	C	T	124386910	3	4	20	1	0	0	0	0	1	0	0	0	6730	710	25	3	334	3	GPR37	7	124386910	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	102446160	124386910	34751753	26	1386										
CA13	377677	broad.mit.edu	37	chr8	86193464	86193464	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tttcttcttctacagctggcCaaatttcgcagtctcctgtg	7	12	4	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr8:86193464C>G	ENST00000321764.3	+	7	977	c.675C>G	c.(673-675)gcC>gcG	p.A225A		NM_198584.2	NP_940986.1	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	225					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			large_intestine(1)|lung(6)	7						TACAGCTGGCCAAATTTCGCA	0.463													14	207					0	0	1	0	0	G	86193464	C	G	86193464	2	3	20	1	0	0	0	0	0	0	0	1	2532	581	21	5		5	CA13	8	86193464	Silent	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		86193464	60170558	27	1387										
C8orf76	84933	broad.mit.edu	37	chr8	124243797	124243797	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ctgtgctgtttctgagatgaCgcaagtgctgctgaaagagc	13	8	1	4			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr8:124243797C>T	ENST00000276704.4	-	4	609	c.558G>A	c.(556-558)gcG>gcA	p.A186A	C8orf76_ENST00000521310.1_5'UTR|ZHX1-C8ORF76_ENST00000357082.4_Silent_p.A154A	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	186							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TCTGAGATGACGCAAGTGCTG	0.438													18	128					0	0	1	0	0	T	124243797	C	T	124243797	2	4	20	1	0	0	0	0	0	0	0	1	2455	523	19	1		1	C8orf76	8	124243797	Silent	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	38050333	124243797	22120225	28	1388										
MYC	4609	broad.mit.edu	37	chr8	128753004	128753004	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ggaacgagctaaaacggagcTtttttgccctgcgtgaccag	12	10	0	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr8:128753004T>C	ENST00000377970.2	+	3	1675	c.1165T>C	c.(1165-1167)Ttt>Ctt	p.F389L	MYC_ENST00000524013.1_Missense_Mutation_p.F388L	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	374	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		AAAACGGAGCTTTTTTGCCCT	0.522		3	"A, T"	"IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"	"Burkitt lymphoma,  amplified in other cancers, B-CLL"								119	132					0	0	1	0	0	C	128753004	T	C	128753004	3	2	20	1	0	0	0	0	1	0	0	0	10063	1609	56	4	1175	4	MYC	8	128753004	Missense_Mutation	SNP	T	TCGA-N6-A4VG-01A-31D-A28R-08	4509207	128753004	17611018	29	1389										
NTRK2	4915	broad.mit.edu	37	chr9	87635192	87635192	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	atgtacaggaaattcacgacGgaaagcgacgtctggagcct	12	9	2	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr9:87635192G>A	ENST00000376214.1	+	20	3182	c.2244G>A	c.(2242-2244)acG>acA	p.T748T	NTRK2_ENST00000376213.1_Silent_p.T732T|NTRK2_ENST00000323115.4_Silent_p.T732T|NTRK2_ENST00000277120.3_Silent_p.T748T	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	732	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						AATTCACGACGGAAAGCGACG	0.552										TSP Lung(25;0.17)			46	78					0	0	1	0	0	A	87635192	G	A	87635192	2	1	20	1	0	0	0	0	0	0	0	1	10754	1103	39	1		1	NTRK2	9	87635192	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08		87635192	53578239	30	1390										
PHF19	26147	broad.mit.edu	37	chr9	123628012	123628012	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ccaagctgcaggagctcccaGtggtggttgacaaaggccag	14	11	0	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr9:123628012G>T	ENST00000373896.3	-	9	1128	c.876C>A	c.(874-876)caC>caA	p.H292Q	PHF19_ENST00000487555.1_5'UTR|PHF19_ENST00000419155.1_Missense_Mutation_p.H83Q	NM_015651.1	NP_056466.1	Q5T6S3	PHF19_HUMAN	PHD finger protein 19	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGAGCTCCCAGTGGTGGTTGA	0.557													20	55					2.37509e-13	2.70395e-13	1	1	0	T	123628012	G	T	123628012	3	4	20	1	0	0	0	0	1	0	0	0	11876	1020	36	5	894	5	PHF19	9	123628012	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	35992820	123628012	17585419	31	1391										
CUTC	51076	broad.mit.edu	37	chr10	101492109	101492109	+	Frame_Shift_Del	DEL	A	A	-													0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ggaggaacgcgtggagcatgAaaaggcagggggcctcctct							TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr10:101492109delA	ENST00000370476.5	+	1	133	c.4delA	c.(4-6)aafs	p.K2fs	CUTC_ENST00000493385.1_Intron	NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	2					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		GTGGAGCATGAAAAGGCAGGG	0.677													2	4	---	---	---	---						-	101492109	A	-	101492109	7	5	20	1	0	1	0	1	0	0	0	0	4086	247	9	0	6	0	CUTC	10	101492109	Frame_Shift_Del	DEL	A	TCGA-N6-A4VG-01A-31D-A28R-08		101492109	34042638	32	1392										
HPX	3263	broad.mit.edu	37	chr11	6452620	6452620	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ttccatacacaaggctccgtCtaccttctcatggggccaag	8	14	2	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr11:6452620C>T	ENST00000265983.3	-	10	1310	c.1210G>A	c.(1210-1212)Gac>Aac	p.D404N		NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin	404					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		AAGGCTCCGTCTACCTTCTCA	0.572													47	10					0	0	1	0	0	T	6452620	C	T	6452620	3	4	20	1	0	0	0	0	1	0	0	0	7386	913	32	3	182	3	HPX	11	6452620	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		6452620	128553896	33	1393										
OR5F1	338674	broad.mit.edu	37	chr11	55761779	55761779	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	agaggatgcattcggttgtcGccagggagataaagaagtac	14	6	0	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr11:55761779G>A	ENST00000278409.1	-	1	322	c.323C>T	c.(322-324)gCg>gTg	p.A108V		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TTCGGTTGTCGCCAGGGAGAT	0.478													52	34					0	0	1	0	0	A	55761779	G	A	55761779	3	1	20	1	0	0	0	0	1	0	0	0	11204	1087	38	1	624	1	OR5F1	11	55761779	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	49309159	55761779	79244737	34	1394										
SLC2A14	144195	broad.mit.edu	37	chr12	7982369	7982369	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	agttctagagtacctgggccAccagaattccaataactatg	8	10	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr12:7982369A>C	ENST00000543909.1	-	10	1334	c.575T>G	c.(574-576)gTg>gGg	p.V192G	SLC2A14_ENST00000539924.1_Missense_Mutation_p.V207G|SLC2A14_ENST00000542546.1_Missense_Mutation_p.V83G|SLC2A14_ENST00000542505.1_Intron|SLC2A14_ENST00000396589.2_Missense_Mutation_p.V192G|SLC2A14_ENST00000535295.1_Missense_Mutation_p.V83G|SLC2A14_ENST00000340749.5_Missense_Mutation_p.V169G|SLC2A14_ENST00000431042.2_Missense_Mutation_p.V169G			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	192					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		TACCTGGGCCACCAGAATTCC	0.443													20	30					0	0	1	0	0	C	7982369	A	C	7982369	3	2	20	1	0	0	0	0	1	0	0	0	14597	159	6	4	1015	4	SLC2A14	12	7982369	Missense_Mutation	SNP	A	TCGA-N6-A4VG-01A-31D-A28R-08		7982369	125869526	35	1395										
ALKBH2	121642	broad.mit.edu	37	chr12	109526301	109526301	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tcggtgctccccgatgtggtCacagccatctttatacctgc	9	14	2	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr12:109526301C>G	ENST00000429722.2	-	4	859	c.496G>C	c.(496-498)Gac>Cac	p.D166H	ALKBH2_ENST00000343075.3_Missense_Mutation_p.D166H|ALKBH2_ENST00000440112.2_Silent_p.V99V	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	166	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	CCGATGTGGTCACAGCCATCT	0.532								Direct reversal of damage					13	104					0	0	1	0	0	G	109526301	C	G	109526301	3	3	20	1	0	0	0	0	1	0	0	0	523	826	29	2	293	2	ALKBH2	12	109526301	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	101543932	109526301	24325594	36	1396										
RXFP2	122042	broad.mit.edu	37	chr13	32335879	32335879	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	aggtgacactagtggatgggCgaccatatttggcacagtgc	14	8	0	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr13:32335879C>T	ENST00000298386.2	+	3	331	c.260C>T	c.(259-261)gCg>gTg	p.A87V	RXFP2_ENST00000380314.1_Missense_Mutation_p.A87V	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	87						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		AGTGGATGGGCGACCATATTT	0.383													15	16					0	0	1	0	0	T	32335879	C	T	32335879	3	4	20	1	0	0	0	0	1	0	0	0	13811	768	27	1	270	1	RXFP2	13	32335879	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		32335879	82833999	37	1397										
FREM2	341640	broad.mit.edu	37	chr13	39451347	39451347	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tgtctgatggatccatgggaTtcgggcaagagagtgatgtt	15	5	1	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr13:39451347T>C	ENST00000280481.7	+	21	8854	c.8638T>C	c.(8638-8640)Ttc>Ctc	p.F2880L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2880					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATCCATGGGATTCGGGCAAGA	0.438													80	94					0	0	1	0	0	C	39451347	T	C	39451347	3	2	20	1	0	0	0	0	1	0	0	0	6079	1493	52	4	8720	4	FREM2	13	39451347	Missense_Mutation	SNP	T	TCGA-N6-A4VG-01A-31D-A28R-08	7115468	39451347	75718531	38	1398										
TP53	7157	broad.mit.edu	37	chr17	7578290	7578290	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	atgctgaggaggggccagacCtaagagcaatcagtgaggaa	15	7	1	4			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr17:7578290C>T	ENST00000420246.2	-	6	692		c.e6-1		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(40)|p.0?(8)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGCCAGACCTAAGAGCAAT	0.552		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	4					0	0	1	0	0	T	7578290	C	T	7578290	5	4	20	1	0	0	0	0	0	0	1	0	16441	695	24	3	735	3	TP53	17	7578290	Splice_Site	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		7578290	73616920	39	1399										
DNAH2	146754	broad.mit.edu	37	chr17	7702525	7702525	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gtgcagaacaacctgcacatCgtgctctgcctcagccccat	8	16	2	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr17:7702525C>T	ENST00000572933.1	+	56	10124	c.8664C>T	c.(8662-8664)atC>atT	p.I2888I	DNAH2_ENST00000389173.2_Silent_p.I2888I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2888	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.I2888I(1)		NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACCTGCACATCGTGCTCTGCC	0.592													38	2					0	0	1	0	0	T	7702525	C	T	7702525	2	4	20	1	0	0	0	0	0	0	0	1	4630	874	31	1		1	DNAH2	17	7702525	Silent	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	124235	7702525	73492685	40	1400										
SDF2	6388	broad.mit.edu	37	chr17	26976153	26976153	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gataggtcgaccatattgttCtcctgtgacagacagcagta	10	9	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr17:26976153C>T	ENST00000247020.4	-	3	788	c.490G>A	c.(490-492)Gaa>Aaa	p.E164K	SDF2_ENST00000592250.1_5'UTR	NM_006923.3	NP_008854.2	Q99470	SDF2_HUMAN	stromal cell-derived factor 2	164	MIR 3.				protein glycosylation	extracellular space|membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Lung NSC(42;0.00431)					CCATATTGTTCTCCTGTGACA	0.507													18	52					0	0	1	0	0	T	26976153	C	T	26976153	3	4	20	1	0	0	0	0	1	0	0	0	14013	922	32	3	149	3	SDF2	17	26976153	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	19273628	26976153	54219057	41	1401										
CNTNAP1	8506	broad.mit.edu	37	chr17	40847636	40847636	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ttctcccacatgctgagccgGccagtgccaggctatgagcc	11	15	1	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr17:40847636G>A	ENST00000264638.4	+	19	3307	c.3090G>A	c.(3088-3090)cgG>cgA	p.R1030R	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	1030					axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TGCTGAGCCGGCCAGTGCCAG	0.622													6	57					0	0	1	0	0	A	40847636	G	A	40847636	2	1	20	1	0	0	0	0	0	0	0	1	3669	1190	42	3		3	CNTNAP1	17	40847636	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	13871483	40847636	40347574	42	1402										
BZRAP1	9256	broad.mit.edu	37	chr17	56382951	56382951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ggggttgtagtcaaatgcagCcaccatggagtggggagctt	16	7	1	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr17:56382951C>T	ENST00000355701.3	-	28	6181	c.5311G>A	c.(5311-5313)Gct>Act	p.A1771T	BZRAP1_ENST00000268893.6_Missense_Mutation_p.A1711T|BZRAP1_ENST00000343736.4_Missense_Mutation_p.A1771T	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1771	SH3 3.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCAAATGCAGCCACCATGGAG	0.602													10	7					0	0	1	0	0	T	56382951	C	T	56382951	3	4	20	1	0	0	0	0	1	0	0	0	1580	739	26	3	278	3	BZRAP1	17	56382951	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	15535315	56382951	24812259	43	1403										
REXO1	57455	broad.mit.edu	37	chr19	1828425	1828425	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gccagggcgggggcctcggcGgagcggtgctcacgggtcgt	21	12	1	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr19:1828425G>A	ENST00000170168.4	-	2	457	c.363C>T	c.(361-363)tcC>tcT	p.S121S	REXO1_ENST00000587524.1_5'UTR	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	121						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		gggccTCGGCGGAGCGGTGCT	0.731													18	2					0	0	1	0	0	A	1828425	G	A	1828425	2	1	20	1	0	0	0	0	0	0	0	1	13292	1103	39	1		1	REXO1	19	1828425	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08		1828425	57300558	44	1404										
LRP3	4037	broad.mit.edu	37	chr19	33696691	33696691	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ggcccgtgagcctggaggccGcccagggccgcctcactgtg	16	16	1	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr19:33696691G>A	ENST00000253193.7	+	5	1217	c.1015G>A	c.(1015-1017)Gcc>Acc	p.A339T		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	339	CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					CCTGGAGGCCGCCCAGGGCCG	0.711													3	14					0	0	1	0	0	A	33696691	G	A	33696691	3	1	20	1	0	0	0	0	1	0	0	0	9002	1087	38	1	1033	1	LRP3	19	33696691	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	31868266	33696691	25432292	45	1405										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41808612	41808612	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tggggacttcctggatgaggTtctgttcattgagctgcagc	14	8	2	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr19:41808612T>G	ENST00000392006.3	+	12	1903	c.1730T>G	c.(1729-1731)gTt>gGt	p.V577G	HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.V477G|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.V477G|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.V488G|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.V477G|HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.V463G|HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.V577G	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	577	Necessary for interaction with BRD7 and transcriptional activation.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						CTGGATGAGGTTCTGTTCATT	0.547													37	52					0	0	1	0	0	G	41808612	T	G	41808612	3	3	20	1	0	0	0	0	1	0	0	0	7314	1725	60	4	1776	4	HNRNPUL1	19	41808612	Missense_Mutation	SNP	T	TCGA-N6-A4VG-01A-31D-A28R-08	8111921	41808612	17320371	46	1406										
ZNF404	342908	broad.mit.edu	37	chr19	44377285	44377285	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gcctctacaaaaggcctttcCacaatccttacaatcataga	4	13	2	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr19:44377285C>T	ENST00000587539.1	-	3	1080	c.1081G>A	c.(1081-1083)Gga>Aga	p.G361R	ZNF404_ENST00000324394.6_Missense_Mutation_p.G359R	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				AAGGCCTTTCCACAATCCTTA	0.393													17	14					0	0	1	0	0	T	44377285	C	T	44377285	3	4	20	1	0	0	0	0	1	0	0	0	17942	603	21	3	581	3	ZNF404	19	44377285	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	2568673	44377285	14751698	47	1407										
SLC8A2	6543	broad.mit.edu	37	chr19	47935656	47935656	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	atcacgtagtcaaagcacgaCggcagccgctcctcccggga	11	15	2	0	rs144930504	byFrequency	TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr19:47935656C>T	ENST00000236877.6	-	9	2552	c.2157G>A	c.(2155-2157)ccG>ccA	p.P719P	SLC8A2_ENST00000539381.1_Silent_p.P182P|SLC8A2_ENST00000542837.1_Silent_p.P475P	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	719					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CAAAGCACGACGGCAGCCGCT	0.637													40	73					0	0	1	0	0	T	47935656	C	T	47935656	2	4	20	1	0	0	0	0	0	0	0	1	14761	523	19	1		1	SLC8A2	19	47935656	Silent	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	3558371	47935656	11193327	48	1408										
FASTKD5	60493	broad.mit.edu	37	chr20	3127481	3127481	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	caacttttctaagcgagttcGtttcagtagtgggagccatt	10	8	2	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:3127481G>C	ENST00000380266.3	-	2	2557	c.2236C>G	c.(2236-2238)Cga>Gga	p.R746G	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	746	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						AAGCGAGTTCGTTTCAGTAGT	0.488													35	83					0	0	1	0	0	C	3127481	G	C	3127481	3	2	20	1	0	0	0	0	1	0	0	0	5720	1153	40	5	62	5	FASTKD5	20	3127481	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08		3127481	59898039	49	1409										
FOXA2	3170	broad.mit.edu	37	chr20	22563198	22563198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gccgggcttgtcgggcgagcGgggcaccttcaggaaacagt	17	11	1	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:22563198G>A	ENST00000419308.2	-	2	866	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C	FOXA2_ENST00000377115.4_Missense_Mutation_p.R222C|FOXA2_ENST00000319993.4_Missense_Mutation_p.R228C	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	222					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					TCGGGCGAGCGGGGCACCTTC	0.627													53	36					0	0	1	0	0	A	22563198	G	A	22563198	3	1	20	1	0	0	0	0	1	0	0	0	6022	1116	39	1	713	1	FOXA2	20	22563198	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	19435717	22563198	40462322	50	1410										
TGIF2	60436	broad.mit.edu	37	chr20	35207242	35207242	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ggcgggcaaaaggaagcgcaGggggaacctgcccaaggagt	18	9	0	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:35207242G>C	ENST00000373874.2	+	2	264	c.65G>C	c.(64-66)aGg>aCg	p.R22T	TGIF2-C20orf24_ENST00000558530.1_Missense_Mutation_p.R22T|RP5-977B1.11_ENST00000561134.1_RNA|TGIF2_ENST00000373872.4_Missense_Mutation_p.R22T	NM_001199514.1|NM_001199515.1	NP_001186443.1|NP_001186444.1	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	22						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(3)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				AGGAAGCGCAGGGGGAACCTG	0.602													52	123					0	0	1	0	0	C	35207242	G	C	35207242	3	2	20	1	0	0	0	0	1	0	0	0	15885	1000	35	5	67	5	TGIF2	20	35207242	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	12644044	35207242	27818278	51	1411										
RPN2	6185	broad.mit.edu	37	chr20	35862430	35862430	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ccccatcattcagtggatccGgattggtgccaatgtctcca	9	13	3	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:35862430G>T	ENST00000237530.6	+	15	1996	c.1685G>T	c.(1684-1686)cGg>cTg	p.R562L	RPN2_ENST00000373622.5_Missense_Mutation_p.R530L|RPN2_ENST00000470352.1_3'UTR	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	562					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				CAGTGGATCCGGATTGGTGCC	0.448													6	53					0.00198382	0.00203892	1	1	0	T	35862430	G	T	35862430	3	4	20	1	0	0	0	0	1	0	0	0	13659	1116	39	5	1743	5	RPN2	20	35862430	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	655188	35862430	27163090	52	1412										
SLC12A5	57468	broad.mit.edu	37	chr20	44682317	44682317	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	cacatttctgtatcatttacGcatcactgcggaggtcgagg	10	10	3	0			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:44682317G>A	ENST00000454036.1	+	20	2793	c.2717G>A	c.(2716-2718)cGc>cAc	p.R906H	SLC12A5_ENST00000243964.3_Missense_Mutation_p.R883H	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	906					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity	p.R883H(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TATCATTTACGCATCACTGCG	0.547													63	116					0	0	1	0	0	A	44682317	G	A	44682317	3	1	20	1	0	0	0	0	1	0	0	0	14440	1087	38	1	2851	1	SLC12A5	20	44682317	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	8819887	44682317	18343203	53	1413										
YTHDF1	54915	broad.mit.edu	37	chr20	61835075	61835075	+	Frame_Shift_Del	DEL	C	C	-													0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	ccctgcagtagaccacggagCctcattgagggagtaaggaa							TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:61835075delC	ENST00000370339.3	-	4	558	c.217delG	c.(217-219)ctfs	p.A73fs	YTHDF1_ENST00000370333.4_Frame_Shift_Del_p.A23fs|YTHDF1_ENST00000370334.4_Intron	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	73										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GACCACGGAGCCTCATTGAGG	0.517													44	93	---	---	---	---						-	61835075	C	-	61835075	7	5	20	1	0	1	0	1	0	0	0	0	17557	739	26	0	1470	0	YTHDF1	20	61835075	Frame_Shift_Del	DEL	C	TCGA-N6-A4VG-01A-31D-A28R-08	17152758	61835075	1190445	54	1414										
ZNF512B	57473	broad.mit.edu	37	chr20	62598842	62598842	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	aagcagagaggggcctggccGggcactgtctgtccaccacg	15	13	1	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr20:62598842G>A	ENST00000450537.1	-	3	216	c.156C>T	c.(154-156)ccC>ccT	p.P52P	ZNF512B_ENST00000369888.1_Silent_p.P52P|ZNF512B_ENST00000217130.3_Silent_p.P52P			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGGCCTGGCCGGGCACTGTCT	0.637													119	104					0	0	1	0	0	A	62598842	G	A	62598842	2	1	20	1	0	0	0	0	0	0	0	1	18013	1103	39	1		1	ZNF512B	20	62598842	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	763767	62598842	426678	55	1415										
TPTE	7179	broad.mit.edu	37	chr21	10969073	10969073	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	tcttcatgtatttataactcAcctttcactgataggtgaca	5	9	4	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr21:10969073A>T	ENST00000361285.4	-	7	503		c.e7+1		TPTE_ENST00000342420.5_Intron|TPTE_ENST00000415664.2_Intron|TPTE_ENST00000298232.7_Intron	NM_199261.2	NP_954870.2	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTATAACTCACCTTTCACTG	0.428													17	77					0	0	1	0	0	T	10969073	A	T	10969073	5	4	20	1	0	0	0	0	0	0	1	0	16490	173	6	4	1552	4	TPTE	21	10969073	Splice_Site	SNP	A	TCGA-N6-A4VG-01A-31D-A28R-08		10969073	37160822	56	1416										
GRIK1	2897	broad.mit.edu	37	chr21	31045468	31045468	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gagggagctttgatgagctcTtgtagacgaattagacctag	13	6	1	4			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr21:31045468T>C	ENST00000399914.1	-	4	1082	c.561A>G	c.(559-561)caA>caG	p.Q187Q	GRIK1_ENST00000399907.1_Silent_p.Q187Q|GRIK1_ENST00000389124.2_Silent_p.Q187Q|GRIK1_ENST00000389125.3_Silent_p.Q187Q|GRIK1_ENST00000399909.1_Silent_p.Q187Q|GRIK1_ENST00000535441.1_Silent_p.Q187Q|GRIK1_ENST00000327783.4_Silent_p.Q187Q|GRIK1_ENST00000309434.7_Silent_p.Q187Q|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000399913.1_Silent_p.Q187Q			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	187					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TGATGAGCTCTTGTAGACGAA	0.393													11	26					0	0	1	0	0	C	31045468	T	C	31045468	2	2	20	1	0	0	0	0	0	0	0	1	6813	1606	56	4		4	GRIK1	21	31045468	Silent	SNP	T	TCGA-N6-A4VG-01A-31D-A28R-08	20076395	31045468	17084427	57	1417										
SGSM1	129049	broad.mit.edu	37	chr22	25251535	25251535	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gatccagaagaggcattccaGtggcagcatggatgaccggc	14	10	0	3			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr22:25251535G>T	ENST00000400358.4	+	8	746	c.689G>T	c.(688-690)aGt>aTt	p.S230I	SGSM1_ENST00000400359.4_Missense_Mutation_p.S230I	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	230						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGGCATTCCAGTGGCAGCATG	0.572													4	45					0.217242	0.217242	1	1	0	T	25251535	G	T	25251535	3	4	20	1	0	0	0	0	1	0	0	0	14275	1029	36	5	719	5	SGSM1	22	25251535	Missense_Mutation	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08		25251535	26053031	58	1418										
MEI1	150365	broad.mit.edu	37	chr22	42128268	42128268	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gggatcgaggcagtggtgagGagcctgcagggaagcctgaa	19	7	0	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chr22:42128268G>A	ENST00000401548.3	+	10	1156	c.1116G>A	c.(1114-1116)agG>agA	p.R372R	MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000540833.1_Silent_p.R112R|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	372							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CAGTGGTGAGGAGCCTGCAGG	0.557													11	1					0	0	1	0	0	A	42128268	G	A	42128268	2	1	20	1	0	0	0	0	0	0	0	1	9514	1165	41	3		3	MEI1	22	42128268	Silent	SNP	G	TCGA-N6-A4VG-01A-31D-A28R-08	16876733	42128268	9176298	59	1419										
SSX7	280658	broad.mit.edu	37	chrX	52677447	52677447	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	gctggcttcttgggcatgatCtttataatgtgaaggtcaca	11	7	3	2			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chrX:52677447C>G	ENST00000298181.5	-	6	489		c.e6-1			NM_173358.2	NP_775494.1	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|skin(1)	16	Ovarian(276;0.236)					TGGGCATGATCTTTATAATGT	0.438													67	33					0	0	1	0	0	G	52677447	C	G	52677447	5	3	20	1	0	0	0	0	0	0	1	0	15264	927	32	2	244	2	SSX7	23	52677447	Splice_Site	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08		52677447	102593113	60	1420										
TAF1	6872	broad.mit.edu	37	chrX	70621556	70621556	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0833333333333333	5	1	1.01648818629951	1.67155835080363	0.805929919137466	1	1	0	acttatcaaggttgaagggaCcaaaattgtcttggggaaac	11	6	2	1			TCGA-N6-A4VG-01A-31D-A28R-08	TCGA-N6-A4VG-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b16ca6e2-7702-4936-87ef-06844abfbbcd	07de55d3-eae6-4710-ab52-6de07c1216b6	g.chrX:70621556C>A	ENST00000449580.1	+	25	4013	c.3962C>A	c.(3961-3963)aCc>aAc	p.T1321N	TAF1_ENST00000276072.3_Missense_Mutation_p.T1342N|TAF1_ENST00000373790.4_Missense_Mutation_p.T1321N|TAF1_ENST00000423759.1_Missense_Mutation_p.T1342N			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1321					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GTTGAAGGGACCAAAATTGTC	0.433													26	13					8.24728e-16	9.53592e-16	1	1	0	A	70621556	C	A	70621556	3	1	20	1	0	0	0	0	1	0	0	0	15569	507	18	5	4123	5	TAF1	23	70621556	Missense_Mutation	SNP	C	TCGA-N6-A4VG-01A-31D-A28R-08	17944109	70621556	84649004	61	1421										
NOC2L	26155	broad.mit.edu	37	chr1	892379	892379	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccccatcttctccttcctcCgctccatcctcctcctcact	1	23	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:892379C>T	ENST00000327044.6	-	4	430	c.381G>A	c.(379-381)gcG>gcA	p.A127A	NOC2L_ENST00000487214.1_5'UTR	NM_015658.3	NP_056473.2	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	127						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CTCCTTCCTCCGCTCCATCCT	0.582													79	103					0	0	1	0	0	T	892379	C	T	892379	2	4	21	1	0	0	0	0	0	0	0	1	10559	639	23	1		1	NOC2L	1	892379	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08		892379	248358242	1	1422										
ERRFI1	54206	broad.mit.edu	37	chr1	8074168	8074169	+	Frame_Shift_Del	DEL	AG	AG	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcacagtctgtgtcatccAgagagagggcttcagagatt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:8074168_8074169delAG	ENST00000377482.5	-	4	713_714	c.490_491delCT	c.(490-492)gfs	p.L164fs	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000469499.1_3'UTR|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	164					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		TGTGTCATCCAGAGAGAGGGCT	0.475													53	70	---	---	---	---						-	8074169	AG	-	8074168	7	5	21	1	0	1	0	1	0	0	0	0	5272	188	7	0	901	0	ERRFI1	1	8074168	Frame_Shift_Del	DEL	AG	TCGA-N7-A4Y0-01A-12D-A28R-08	7181789	8074168	241176453	2	1423										
RERE	473	broad.mit.edu	37	chr1	8416169	8416169	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaagtcttaccgaaaactgGgtggcgaagcatctcgtgct	13	9	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:8416169G>A	ENST00000337907.3	-	22	5111	c.4477C>T	c.(4477-4479)Cca>Tca	p.P1493S	RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.P1493S|RERE_ENST00000377464.1_Missense_Mutation_p.P1225S|RERE_ENST00000476556.1_Missense_Mutation_p.P939S	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1493	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P1493T(1)		central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CCGAAAACTGGGTGGCGAAGC	0.617													115	161					0	0	1	0	0	A	8416169	G	A	8416169	3	1	21	1	0	0	0	0	1	0	0	0	13282	1232	43	3	235	3	RERE	1	8416169	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	342001	8416169	240834452	3	1424										
SPSB1	80176	broad.mit.edu	37	chr1	9416315	9416315	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggggtggcgacggcagacgCccccctgcactctgtcgggt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:9416315delC	ENST00000328089.6	+	2	706	c.365delC	c.(364-366)gcfs	p.A122fs	SPSB1_ENST00000377399.2_Frame_Shift_Del_p.A122fs|SPSB1_ENST00000357898.3_Frame_Shift_Del_p.A122fs	NM_025106.3	NP_079382.2	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box containing 1	122	B30.2/SPRY.				intracellular signal transduction	cytoplasm				breast(1)|endometrium(3)|kidney(2)|lung(5)|prostate(2)	13	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		ACGGCAGACGCCCCCCTGCAC	0.657													40	63	---	---	---	---						-	9416315	C	-	9416315	7	5	21	1	0	1	0	1	0	0	0	0	15167	739	26	0	367	0	SPSB1	1	9416315	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1000146	9416315	239834306	4	1425										
KIF1B	23095	broad.mit.edu	37	chr1	10364532	10364532	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcgccatattcatcaacacCgtcagtcttactgtaattat	5	11	4	0	rs146807975		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:10364532C>T	ENST00000377093.4	+	21	3442	c.3289C>T	c.(3289-3291)Cgt>Tgt	p.R1097C	KIF1B_ENST00000377083.1_Missense_Mutation_p.R1097C|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377081.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TCATCAACACCGTCAGTCTTA	0.507													39	59					0	0	1	0	0	T	10364532	C	T	10364532	3	4	21	1	0	0	0	0	1	0	0	0	8325	652	23	1	3367	1	KIF1B	1	10364532	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	948217	10364532	238886089	5	1426										
DNAJC16	23341	broad.mit.edu	37	chr1	15873320	15873321	+	Frame_Shift_Del	DEL	AT	AT	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagcaagagaataagcctcAtgtccttctgtttgaccaaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:15873320_15873321delAT	ENST00000375847.3	+	6	982_983	c.818_819delAT	c.(817-819)cfs	p.H273fs	DNAJC16_ENST00000375838.1_Frame_Shift_Del_p.H273fs|DNAJC16_ENST00000375849.1_Frame_Shift_Del_p.H273fs	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	273					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AATAAGCCTCATGTCCTTCTGT	0.327													43	83	---	---	---	---						-	15873321	AT	-	15873320	7	5	21	1	0	1	0	1	0	0	0	0	4662	217	8	0	836	0	DNAJC16	1	15873320	Frame_Shift_Del	DEL	AT	TCGA-N7-A4Y0-01A-12D-A28R-08	5508788	15873320	233377301	6	1427										
EPHA2	1969	broad.mit.edu	37	chr1	16456084	16456084	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggggagccggatagacacGctgcaacaggaagcactgca	14	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:16456084G>A	ENST00000358432.5	-	16	2824	c.2669_splice	c.e16-1	p.R890_splice		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	890	Mediates interaction with ARHGEF16 and ELMO2.|Negatively regulates interaction with ARHGEF16.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGATAGACACGCtgcaacagg	0.652													12	28					0	0	1	0	0	A	16456084	G	A	16456084	5	1	21	1	0	0	0	0	0	0	1	0	5195	1101	38	1	268	1	EPHA2	1	16456084	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	582764	16456084	232794537	7	1428										
CROCC	9696	broad.mit.edu	37	chr1	17292527	17292527	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccagaccagtgccctgaatCgccagctggccgagatggag	13	14	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:17292527C>T	ENST00000375541.5	+	29	4678	c.4609C>T	c.(4609-4611)Cgc>Tgc	p.R1537C		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1537					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TGCCCTGAATCGCCAGCTGGC	0.637													26	38					0	0	1	0	0	T	17292527	C	T	17292527	3	4	21	1	0	0	0	0	1	0	0	0	3916	884	31	1	4723	1	CROCC	1	17292527	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	836443	17292527	231958094	8	1429										
PADI6	353238	broad.mit.edu	37	chr1	17727969	17727969	+	RNA	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgccagctctgccccagcGtggatggcccactgtcacca	11	17	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:17727969G>A	ENST00000434762.2	+	0	2171							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CTGCCCCAGCGTGGATGGCCC	0.587													3	21					0	0	1	0	0	A	17727969	G	A	17727969	1	1	21	0	1	0	0	0	0	0	0	0	11427	1160	40	1		1	PADI6	1	17727969	RNA	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	435442	17727969	231522652	9	1430										
RNF186	54546	broad.mit.edu	37	chr1	20141295	20141295	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccaccaccgcctcatggtcGcgcaggctgcagatgaggcc	12	17	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:20141295G>A	ENST00000375121.2	-	1	476	c.300C>T	c.(298-300)cgC>cgT	p.R100R	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	100						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCATGGTCGCGCAGGCTGC	0.667													33	53					0	0	1	0	0	A	20141295	G	A	20141295	2	1	21	1	0	0	0	0	0	0	0	1	13520	1074	38	1		1	RNF186	1	20141295	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2413326	20141295	229109326	10	1431										
ASAP3	55616	broad.mit.edu	37	chr1	23767955	23767955	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttctgtagctcgtcctcctgGgcctgatggagctatgggac	13	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:23767955G>T	ENST00000336689.3	-	9	803	c.759C>A	c.(757-759)gcC>gcA	p.A253A	ASAP3_ENST00000437606.2_Silent_p.A244A	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	253					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CGTCCTCCTGGGCCTGATGGA	0.582													9	20					0.0477658	0.0479846	1	1	0	T	23767955	G	T	23767955	2	4	21	1	0	0	0	0	0	0	0	1	1011	1219	43	5		5	ASAP3	1	23767955	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3626660	23767955	225482666	11	1432										
CATSPER4	378807	broad.mit.edu	37	chr1	26527326	26527326	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcccccgcttcccagacaggCgcagaggaagaggaggagaa	14	12	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:26527326C>T	ENST00000456354.2	+	8	1060	c.993C>T	c.(991-993)ggC>ggT	p.G331G		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	331					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAGACAGGCGCAGAGGAAG	0.627													25	51					0	0	1	0	0	T	26527326	C	T	26527326	2	4	21	1	0	0	0	0	0	0	0	1	2708	755	27	1		1	CATSPER4	1	26527326	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2759371	26527326	222723295	12	1433										
AHDC1	27245	broad.mit.edu	37	chr1	27877512	27877512	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaccctcaggcccgggggggCcgtgcggtgagcacaagtcc	17	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:27877512C>G	ENST00000374011.2	-	6	2083	c.1115G>C	c.(1114-1116)gGc>gCc	p.G372A	AHDC1_ENST00000482400.2_5'UTR|AHDC1_ENST00000247087.5_Missense_Mutation_p.G372A	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	372	Pro-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CCCGGGGGGGCCGTGCGGTGA	0.697													11	15					0	0	1	0	0	G	27877512	C	G	27877512	3	3	21	1	0	0	0	0	1	0	0	0	409	739	26	5	3700	5	AHDC1	1	27877512	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1350186	27877512	221373109	13	1434										
OPRD1	4985	broad.mit.edu	37	chr1	29189255	29189255	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccttgtttccgcggcccagaCggggcagtggtgtgcatgct	15	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:29189255C>T	ENST00000234961.2	+	3	821	c.577_splice	c.e3-1	p.D193_splice		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	193					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	GCGGCCCAGACGGGGCAGTGG	0.637													20	23					0	0	1	0	0	T	29189255	C	T	29189255	5	4	21	1	0	0	0	0	0	0	1	0	10931	550	19	1	589	1	OPRD1	1	29189255	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1311743	29189255	220061366	14	1435										
TRIM62	55223	broad.mit.edu	37	chr1	33625365	33625365	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgctcctgcaggatctgggCtccctcctggaccttgcgca	11	17	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:33625365C>A	ENST00000291416.5	-	3	918	c.685G>T	c.(685-687)Gcc>Tcc	p.A229S	TRIM62_ENST00000485148.1_5'UTR|TRIM62_ENST00000543586.1_Missense_Mutation_p.A108S	NM_018207.2	NP_060677.2	Q9BVG3	TRI62_HUMAN	tripartite motif containing 62	229						intracellular	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)				AGGATCTGGGCTCCCTCCTGG	0.677													42	55					3.61848e-18	3.95686e-18	1	1	0	A	33625365	C	A	33625365	3	1	21	1	0	0	0	0	1	0	0	0	16597	797	28	5	754	5	TRIM62	1	33625365	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4436110	33625365	215625256	15	1436										
KCNQ4	9132	broad.mit.edu	37	chr1	41284281	41284281	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcgcttcctgcagatcctgCgcatggtgcgcatggaccgc	13	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:41284281C>T	ENST00000347132.5	+	4	719	c.637C>T	c.(637-639)Cgc>Tgc	p.R213C	KCNQ4_ENST00000509682.2_Missense_Mutation_p.R213C	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	213					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GCAGATCCTGCGCATGGTGCG	0.687													23	25					0	0	1	0	0	T	41284281	C	T	41284281	3	4	21	1	0	0	0	0	1	0	0	0	8128	768	27	1	651	1	KCNQ4	1	41284281	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7658916	41284281	207966340	16	1437										
STIL	6491	broad.mit.edu	37	chr1	47728788	47728788	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcacaactagagaagagctGctgggaaggatatataatgt	11	6	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:47728788G>A	ENST00000371877.3	-	15	2763	c.2615_splice	c.e15-1	p.N872_splice	STIL_ENST00000396221.2_Intron|STIL_ENST00000360380.3_Intron|STIL_ENST00000337817.5_Intron|STIL_ENST00000243182.6_Intron			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	872					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GAGAAGAGCTGCTGGGAAGGA	0.398													11	18					0	0	1	0	0	A	47728788	G	A	47728788	5	1	21	1	0	0	0	0	0	0	1	0	15337	1333	46	3	1262	3	STIL	1	47728788	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6444507	47728788	201521833	17	1438										
KTI12	112970	broad.mit.edu	37	chr1	52498467	52498467	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtgtacgaaataaactggcGacgaaggcgactcagttctg	12	8	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:52498467G>A	ENST00000371614.1	-	1	1021	c.967C>T	c.(967-969)Cgc>Tgc	p.R323C	TXNDC12_ENST00000371626.4_Intron|TXNDC12_ENST00000472624.1_Intron	NM_138417.2	NP_612426.1	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated (S. cerevisiae)	323							ATP binding			central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)|urinary_tract(1)	12						ATAAACTGGCGACGAAGGCGA	0.537													63	61					0	0	1	0	0	A	52498467	G	A	52498467	3	1	21	1	0	0	0	0	1	0	0	0	8622	1058	37	1	101	1	KTI12	1	52498467	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4769679	52498467	196752154	18	1439										
PODN	127435	broad.mit.edu	37	chr1	53543382	53543382	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caagctggagaagatcccccCgggggccttcagcgagctga	14	13	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:53543382C>G	ENST00000371500.3	+	9	1192	c.851C>G	c.(850-852)cCg>cGg	p.P284R	PODN_ENST00000395871.2_Missense_Mutation_p.P161R|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Missense_Mutation_p.P303R	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	255					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AAGATCCCCCCGGGGGCCTTC	0.612													59	142					0	0	1	0	0	G	53543382	C	G	53543382	3	3	21	1	0	0	0	0	1	0	0	0	12225	652	23	5	934	5	PODN	1	53543382	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1044915	53543382	195707239	19	1440										
TTC22	55001	broad.mit.edu	37	chr1	55266305	55266305	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tagcgccttgtcgtagagcgCgatgcctgccgccagccccc	12	17	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:55266305C>T	ENST00000371276.4	-	1	635	c.532G>A	c.(532-534)Gcg>Acg	p.A178T	TTC22_ENST00000371274.4_Missense_Mutation_p.A178T	NM_001114108.1	NP_001107580.1	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22	178							binding			kidney(1)|large_intestine(1)|lung(7)|skin(1)	10						TCGTAGAGCGCGATGCCTGCC	0.701													9	7					0	0	1	0	0	T	55266305	C	T	55266305	3	4	21	1	0	0	0	0	1	0	0	0	16750	768	27	1	1308	1	TTC22	1	55266305	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1722923	55266305	193984316	20	1441										
C8A	731	broad.mit.edu	37	chr1	57373743	57373743	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caccattacataccgttcctGggggaggtcattaaagtata							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:57373743delG	ENST00000361249.3	+	9	1433	c.1337delG	c.(1336-1338)tgfs	p.W446fs		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	446	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						TACCGTTCCTGGGGGAGGTCA	0.483													41	43	---	---	---	---						-	57373743	G	-	57373743	7	5	21	1	0	1	0	1	0	0	0	0	2432	1357	47	0	1371	0	C8A	1	57373743	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2107438	57373743	191876878	21	1442										
DAB1	1600	broad.mit.edu	37	chr1	57537235	57537235	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actgcttatccttttgtgccTttttttctaattcttctctt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:57537235delT	ENST00000371236.2	-	6	781	c.518delA	c.(517-519)agfs	p.K173fs	DAB1_ENST00000371230.1_Frame_Shift_Del_p.K173fs|DAB1_ENST00000371234.4_Frame_Shift_Del_p.K173fs|DAB1_ENST00000420954.2_Frame_Shift_Del_p.K173fs|DAB1_ENST00000371231.1_Frame_Shift_Del_p.K173fs|DAB1_ENST00000414851.2_Frame_Shift_Del_p.K173fs|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	173	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CTTTTGTGCCTTTTTTTCTAA	0.393													18	44	---	---	---	---						-	57537235	T	-	57537235	7	5	21	1	0	1	0	1	0	0	0	0	4241	1609	56	0	1185	0	DAB1	1	57537235	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	163492	57537235	191713386	22	1443										
MSH4	4438	broad.mit.edu	37	chr1	76262890	76262890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagcagccttccctgccccGcgccaaactcccggccagct	9	21	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:76262890G>A	ENST00000263187.3	+	1	324	c.220G>A	c.(220-222)Gcg>Acg	p.A74T		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	74					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TCCCTGCCCCGCGCCAAACTC	0.672								Mismatch excision repair (MMR)					7	7					0	0	1	0	0	A	76262890	G	A	76262890	3	1	21	1	0	0	0	0	1	0	0	0	9920	1087	38	1	222	1	MSH4	1	76262890	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	18725655	76262890	172987731	23	1444										
NEXN	91624	broad.mit.edu	37	chr1	78408251	78408251	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catggttcaagaagcctcttAaaaacacatcagttgtagac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:78408251delA	ENST00000330010.8	+	12	1870	c.1573delA	c.(1573-1575)aafs	p.K525fs	NEXN_ENST00000457030.1_Frame_Shift_Del_p.K575fs|NEXN_ENST00000334785.7_Frame_Shift_Del_p.K589fs|NEXN_ENST00000480732.1_3'UTR	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	589	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAAGCCTCTTAAAAACACATC	0.438													33	57	---	---	---	---						-	78408251	A	-	78408251	7	5	21	1	0	1	0	1	0	0	0	0	10401	363	13	0	1811	0	NEXN	1	78408251	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2145361	78408251	170842370	24	1445										
DNASE2B	58511	broad.mit.edu	37	chr1	84880445	84880445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgtattggagacctaaatcGgagtccacaccaagccttca	8	11	1	1	rs145614783	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:84880445G>A	ENST00000370665.3	+	6	1013	c.980G>A	c.(979-981)cGg>cAg	p.R327Q	DNASE2B_ENST00000370662.3_Missense_Mutation_p.R119Q	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	327					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		GACCTAAATCGGAGTCCACAC	0.403													33	32					0	0	1	0	0	A	84880445	G	A	84880445	3	1	21	1	0	0	0	0	1	0	0	0	4692	1116	39	1	1002	1	DNASE2B	1	84880445	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6472194	84880445	164370176	25	1446										
HFM1	164045	broad.mit.edu	37	chr1	91845795	91845796	+	Splice_Site	INS	-	-	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctatctgtgtaaagaagctINSaaaaaataaaaagtaatcaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:91845795_91845796insA	ENST00000370425.3	-	8	972		c.e8-2		HFM1_ENST00000370424.3_Splice_Site|HFM1_ENST00000294696.5_Splice_Site	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)								ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTAAAGAAGCTAAAAAATAAAA	0.282													22	49	---	---	---	---						A	91845796	-	A	91845795	8	5	21	1	0	1	1	0	0	0	1	0	7123	1536	53	0	3563	0	HFM1	1	91845795	Splice_Site	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	6965350	91845795	157404826	26	1447										
ARHGAP29	9411	broad.mit.edu	37	chr1	94650983	94650983	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcaatttgcgaaacttgtgtGtgagagctgcctttgacatc	10	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:94650983G>C	ENST00000260526.6	-	17	2017	c.1835C>G	c.(1834-1836)aCa>aGa	p.T612R	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	612					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.T612I(1)		NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AAACTTGTGTGTGAGAGCTGC	0.373													24	37					0	0	1	0	0	C	94650983	G	C	94650983	3	2	21	1	0	0	0	0	1	0	0	0	875	1377	48	5	1978	5	ARHGAP29	1	94650983	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2805188	94650983	154599638	27	1448										
PTBP2	58155	broad.mit.edu	37	chr1	97235320	97235320	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atggatggtgctccttctcgTgtacttcatattcgaaaatt	8	8	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:97235320T>C	ENST00000236228.6	+	4	259	c.177T>C	c.(175-177)cgT>cgC	p.R59R	PTBP2_ENST00000426398.2_Silent_p.R59R|PTBP2_ENST00000541987.1_Silent_p.R28R|PTBP2_ENST00000370197.1_Silent_p.R59R|PTBP2_ENST00000394184.3_Silent_p.R70R|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000370198.1_Silent_p.R59R	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	59	RRM 1.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CTCCTTCTCGTGTACTTCATA	0.343													45	72					0	0	1	0	0	C	97235320	T	C	97235320	2	2	21	1	0	0	0	0	0	0	0	1	12774	1683	59	4		4	PTBP2	1	97235320	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2584337	97235320	152015301	28	1449										
CLCC1	23155	broad.mit.edu	37	chr1	109493059	109493059	+	Translation_Start_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaggagcaaagaacacagcaTcctgtataaggctaaaacaa	8	8	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:109493059T>C	ENST00000356970.2	-	2	108	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	CLCC1_ENST00000415331.1_Start_Codon_SNP_p.M1V|AKNAD1_ENST00000357393.4_Intron|CLCC1_ENST00000369970.3_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369971.2_Splice_Site_p.M1_splice|CLCC1_ENST00000348264.2_Start_Codon_SNP_p.M1V|CLCC1_ENST00000302500.4_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369976.1_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369968.2_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369969.2_Start_Codon_SNP_p.M1V			Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	1						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		GAACACAGCATCCTGTATAAG	0.299													14	18					0	0	1	0	0	C	109493059	T	C	109493059	1	2	21	1	0	0	0	0	0	0	0	0	3483	1449	50	4		4	CLCC1	1	109493059	Translation_Start_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	12257739	109493059	139757562	29	1450										
GPR61	0	broad.mit.edu	37	chr1	110086356	110086356	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgttccgagtggcccgcgtgGctgccatgcagcacgggccg	16	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:110086356G>T	ENST00000527748.1	+	2	1395	c.712G>T	c.(712-714)Gct>Tct	p.A238S	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	238						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGCCCGCGTGGCTGCCATGCA	0.617													98	159					1.94071e-40	2.1933e-40	1	1	0	T	110086356	G	T	110086356	3	4	21	1	0	0	0	0	1	0	0	0	6741	1203	42	5	714	5	GPR61	1	110086356	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	593297	110086356	139164265	30	1451										
KCNA3	3738	broad.mit.edu	37	chr1	111217016	111217016	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgttgcggagcgggtcgaagTacctcatgcgccgcttgggg	17	11	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:111217016T>C	ENST00000369769.2	-	1	639	c.416A>G	c.(415-417)tAc>tGc	p.Y139C		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	139						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGGGTCGAAGTACCTCATGCG	0.647													73	84					0	0	1	0	0	C	111217016	T	C	111217016	3	2	21	1	0	0	0	0	1	0	0	0	8047	1638	57	4	1315	4	KCNA3	1	111217016	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1130660	111217016	138033605	31	1452										
PTGFRN	5738	broad.mit.edu	37	chr1	117484351	117484351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgcagctctttgccgagggCgtgtggtgagagtccccaca	14	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:117484351C>T	ENST00000393203.2	+	2	211	c.64C>T	c.(64-66)Cgt>Tgt	p.R22C		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	22						endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TTGCCGAGGGCGTGTGGTGAG	0.537													48	57					0	0	1	0	0	T	117484351	C	T	117484351	3	4	21	1	0	0	0	0	1	0	0	0	12799	768	27	1	70	1	PTGFRN	1	117484351	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6267335	117484351	131766270	32	1453										
NBPF14	25832	broad.mit.edu	37	chr1	148009407	148009407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtaaaaggcacttctgtaggGctggcatgagtcagtcagtt	13	7	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:148009407G>A	ENST00000369219.1	-	16	1916	c.1900C>T	c.(1900-1902)Ccc>Tcc	p.P634S				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	634	NBPF 7.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					CTTCTGTAGGGCTGGCATGAG	0.473													25	425					0	0	1	0	0	A	148009407	G	A	148009407	3	1	21	1	0	0	0	0	1	0	0	0	10241	1203	42	3	893	3	NBPF14	1	148009407	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	30525056	148009407	101241214	33	1454										
ADAMTSL4	54507	broad.mit.edu	37	chr1	150531877	150531877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttctcacctccccaggcccCctgccctgcagccctgtcaa	7	21	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:150531877C>T	ENST00000271643.4	+	17	3114	c.2878C>T	c.(2878-2880)Cct>Tct	p.P960S	ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.P983S|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.P960S	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	960	TSP type-1 5.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CCCCAGGCCCCCTGCCCTGCA	0.617											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	53					0	0	1	0	0	T	150531877	C	T	150531877	3	4	21	1	0	0	0	0	1	0	0	0	276	623	22	3	3011	3	ADAMTSL4	1	150531877	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2522470	150531877	98718744	34	1455										
ZNF687	57592	broad.mit.edu	37	chr1	151261869	151261869	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcaggctgatctacaagtgCgccatgtgcgacacagtctt	10	11	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:151261869C>T	ENST00000368879.2	+	5	2585	c.2487C>T	c.(2485-2487)tgC>tgT	p.C829C		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTACAAGTGCGCCATGTGCG	0.612													64	86					0	0	1	0	0	T	151261869	C	T	151261869	2	4	21	1	0	0	0	0	0	0	0	1	18147	776	27	1		1	ZNF687	1	151261869	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	729992	151261869	97988752	35	1456										
PI4KB	5298	broad.mit.edu	37	chr1	151265430	151265432	+	In_Frame_Del	DEL	CTC	CTC	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccaccagcagctgcagctgCtcctcagtcatgctcatgtg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:151265430_151265432delCTC	ENST00000368875.2	-	13	2963_2965	c.2383_2385delGAG	c.(2383-2385)del	p.E795del	PI4KB_ENST00000368873.1_In_Frame_Del_p.E783del|PI4KB_ENST00000271657.5_In_Frame_Del_p.E795del|PI4KB_ENST00000368874.4_In_Frame_Del_p.E768del|PI4KB_ENST00000529142.1_In_Frame_Del_p.E451del|PI4KB_ENST00000368872.1_In_Frame_Del_p.E768del	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	783					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCTGCAGCTGCTCCTCAGTCATG	0.542													38	55	---	---	---	---						-	151265432	CTC	-	151265430	7	5	21	1	0	1	0	1	0	0	0	0	11921	796	28	0	105	0	PI4KB	1	151265430	In_Frame_Del	DEL	CTC	TCGA-N7-A4Y0-01A-12D-A28R-08	3561	151265430	97985191	36	1457										
HRNR	388697	broad.mit.edu	37	chr1	152188528	152188528	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctgagccagacccatgtcgGccactgctggaagaccaacc	10	16	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152188528G>A	ENST00000368801.2	-	3	5652	c.5577C>T	c.(5575-5577)ggC>ggT	p.G1859G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1859					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCCATGTCGGCCACTGCTGG	0.597													85	890					0	0	1	0	0	A	152188528	G	A	152188528	2	1	21	1	0	0	0	0	0	0	0	1	7399	1190	42	3		3	HRNR	1	152188528	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	923098	152188528	97062093	37	1458										
FLG	2312	broad.mit.edu	37	chr1	152281526	152281526	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atctcttgactgctcccaagCagatccaagatggtttctgg	9	11	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152281526C>T	ENST00000368799.1	-	3	5871	c.5836G>A	c.(5836-5838)Gct>Act	p.A1946T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1946	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCCAAGCAGATCCAAGA	0.567									Ichthyosis				173	304					0	0	1	0	0	T	152281526	C	T	152281526	3	4	21	1	0	0	0	0	1	0	0	0	5954	710	25	3	6353	3	FLG	1	152281526	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	92998	152281526	96969095	38	1459										
CRNN	49860	broad.mit.edu	37	chr1	152384693	152384693	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgatgatcccattaatgtttTgcagtaactgaggcatcttt	8	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152384693T>C	ENST00000271835.3	-	2	79	c.17A>G	c.(16-18)cAa>cGa	p.Q6R	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	6					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTAATGTTTTGCAGTAACTG	0.493													67	87					0	0	1	0	0	C	152384693	T	C	152384693	3	2	21	1	0	0	0	0	1	0	0	0	3915	1812	63	4	1478	4	CRNN	1	152384693	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	103167	152384693	96865928	39	1460										
LCE1B	353132	broad.mit.edu	37	chr1	152784988	152784988	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcatccccaagtgccctccCaagtgcctcacccctagatg	7	18	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152784988C>A	ENST00000360090.3	+	1	542	c.66C>A	c.(64-66)ccC>ccA	p.P22P		NM_178349.1	NP_848126.1	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	22	Pro-rich.				keratinization					breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|skin(2)	18	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			agtgccctcccaagtgccTCA	0.617													47	76					4.10826e-27	4.59559e-27	1	1	0	A	152784988	C	A	152784988	2	1	21	1	0	0	0	0	0	0	0	1	8698	581	21	5		5	LCE1B	1	152784988	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	400295	152784988	96465633	40	1461										
S100A13	6284	broad.mit.edu	37	chr1	153591516	153591516	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catcaagagagcccacatccTgaggagacaccaaagggaag	11	11	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:153591516T>C	ENST00000368699.1	-	5	657		c.e5-2		S100A13_ENST00000339556.4_Splice_Site|S100A13_ENST00000491177.1_Splice_Site|S100A13_ENST00000392623.1_Splice_Site|S100A13_ENST00000440685.2_Splice_Site|S100A13_ENST00000392622.1_Splice_Site	NM_001024210.1	NP_001019381.1	Q99584	S10AD_HUMAN	S100 calcium binding protein A13						interleukin-1 alpha secretion|mast cell degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|extracellular space|nucleus|perinuclear region of cytoplasm	calcium ion binding|copper ion binding|fibroblast growth factor 1 binding|lipid binding|protein homodimerization activity|RAGE receptor binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(4)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	GCCCACATCCTGAGGAGACAC	0.502													101	112					0	0	1	0	0	C	153591516	T	C	153591516	5	2	21	1	0	0	0	0	0	0	1	0	13826	1594	55	4	148	4	S100A13	1	153591516	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	806528	153591516	95659105	41	1462										
CRTC2	200186	broad.mit.edu	37	chr1	153923897	153923898	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggggtagaagcagggtaagaINSgggggcgcccaaaacaggag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:153923897_153923898insG	ENST00000368633.1	-	11	1369_1370	c.1242_1243insC	c.(1240-1245)cccttafs	p.PL414fs	CRTC2_ENST00000368630.3_Frame_Shift_Ins_p.PL94fs	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	414					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCAGGGTAAGAGGGGGCGCCCA	0.673													10	18	---	---	---	---						G	153923898	-	G	153923897	7	5	21	1	0	1	1	0	0	0	0	0	3923	304	11	0	854	0	CRTC2	1	153923897	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	332381	153923897	95326724	42	1463										
SLC39A1	27173	broad.mit.edu	37	chr1	153932984	153932984	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccctcgaacacggagtggaGggccagggagaacaccagta	14	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:153932984G>T	ENST00000368623.3	-	3	1324	c.565C>A	c.(565-567)Ctc>Atc	p.L189I	SLC39A1_ENST00000537590.1_Missense_Mutation_p.L87I|SLC39A1_ENST00000356205.4_Missense_Mutation_p.L189I|SLC39A1_ENST00000368621.1_Missense_Mutation_p.L189I|SLC39A1_ENST00000310483.6_Missense_Mutation_p.L189I			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	189						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		ACGGAGTGGAGGGCCAGGGAG	0.677													31	33					9.78306e-22	1.08194e-21	1	1	0	T	153932984	G	T	153932984	3	4	21	1	0	0	0	0	1	0	0	0	14666	1000	35	5	413	5	SLC39A1	1	153932984	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9087	153932984	95317637	43	1464										
MSTO1	55154	broad.mit.edu	37	chr1	155717654	155717654	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcagggcggggaataataacTtggggcctgctacctggtcc	14	10	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:155717654T>C	ENST00000452804.2	+	7	922	c.861T>C	c.(859-861)acT>acC	p.T287T				Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	260					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					GAATAATAACTTGGGGCCTGC	0.532													18	57					0	0	1	0	0	C	155717654	T	C	155717654	2	2	21	1	0	0	0	0	0	0	0	1	9941	1624	56	4		4	MSTO1	1	155717654	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1784670	155717654	93532967	44	1465										
ATP1A4	480	broad.mit.edu	37	chr1	160141103	160141103	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgatgatgaagggtgctccGgagaggatcttggagttttg	16	5	1	4	rs142215427		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:160141103G>A	ENST00000368081.4	+	11	2025	c.1554G>A	c.(1552-1554)ccG>ccA	p.P518P		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	518					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGGTGCTCCGGAGAGGATCT	0.502													56	62					0	0	1	0	0	A	160141103	G	A	160141103	2	1	21	1	0	0	0	0	0	0	0	1	1130	1103	39	1		1	ATP1A4	1	160141103	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4423449	160141103	89109518	45	1466										
ILDR2	387597	broad.mit.edu	37	chr1	166890248	166890248	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccgcgcgctgcccaggtacGagtggtcgtatttgggtgcg	16	12	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:166890248G>A	ENST00000271417.3	-	9	1635	c.1580C>T	c.(1579-1581)tCg>tTg	p.S527L	ILDR2_ENST00000528703.1_Missense_Mutation_p.S468L|ILDR2_ENST00000469934.2_Intron|ILDR2_ENST00000525740.1_Missense_Mutation_p.S400L|ILDR2_ENST00000529071.1_Missense_Mutation_p.S508L|ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000526687.1_Missense_Mutation_p.S419L	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	527						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						GCCCAGGTACGAGTGGTCGTA	0.776													3	7					0	0	1	0	0	A	166890248	G	A	166890248	3	1	21	1	0	0	0	0	1	0	0	0	7753	1059	37	1	347	1	ILDR2	1	166890248	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6749145	166890248	82360373	46	1467										
DUSP27	92235	broad.mit.edu	37	chr1	167095958	167095958	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctctgaggccagttccttCtacaacttctgcagcaggaa	10	12	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:167095958C>A	ENST00000361200.2	+	6	1756	c.1590C>A	c.(1588-1590)ttC>ttA	p.F530L	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.F530L|DUSP27_ENST00000271385.5_Missense_Mutation_p.F530L			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	530					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCAGTTCCTTCTACAACTTCT	0.542													47	60					2.24722e-20	2.48213e-20	1	1	0	A	167095958	C	A	167095958	3	1	21	1	0	0	0	0	1	0	0	0	4850	912	32	2	1608	2	DUSP27	1	167095958	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	205710	167095958	82154663	47	1468										
ABL2	27	broad.mit.edu	37	chr1	179078368	179078368	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agttcgtatttcttatggggCtgattctccatttctcggaa	9	8	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:179078368C>T	ENST00000502732.1	-	12	2237	c.2034G>A	c.(2032-2034)caG>caA	p.Q678Q	ABL2_ENST00000504405.1_Silent_p.Q642Q|ABL2_ENST00000344730.3_Silent_p.Q663Q|ABL2_ENST00000511413.1_Silent_p.Q678Q|ABL2_ENST00000367623.4_Silent_p.Q657Q|ABL2_ENST00000408940.3_Silent_p.Q642Q|ABL2_ENST00000507173.1_Silent_p.Q657Q|ABL2_ENST00000512653.1_Silent_p.Q663Q	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	678					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TCTTATGGGGCTGATTCTCCA	0.512			T	ETV6	AML								86	179					0	0	1	0	0	T	179078368	C	T	179078368	2	4	21	1	0	0	0	0	0	0	0	1	93	796	28	3		3	ABL2	1	179078368	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	11982410	179078368	70172253	48	1469										
CFHR1	3078	broad.mit.edu	37	chr1	196799690	196799690	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggggacattacttcattccCgttgtcagtatatgctccag	9	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:196799690C>T	ENST00000320493.5	+	5	756	c.668C>T	c.(667-669)cCg>cTg	p.P223L	CFHR2_ENST00000367421.3_Intron|CFHR1_ENST00000367424.3_Missense_Mutation_p.P164L	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	223	Sushi 4.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						ACTTCATTCCCGTTGTCAGTA	0.413													57	8					0	0	1	0	0	T	196799690	C	T	196799690	3	4	21	1	0	0	0	0	1	0	0	0	3306	652	23	1	686	1	CFHR1	1	196799690	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	17721322	196799690	52450931	49	1470										
PPFIA4	8497	broad.mit.edu	37	chr1	203025953	203025953	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caaccccagcagcagcaacaGcagccaggactccctgcaca	8	18	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:203025953G>A	ENST00000367240.2	+	18	2746	c.2219G>A	c.(2218-2220)aGc>aAc	p.S740N	PPFIA4_ENST00000599966.1_Missense_Mutation_p.S255N|PPFIA4_ENST00000414050.2_Missense_Mutation_p.S468N|PPFIA4_ENST00000272198.6_Missense_Mutation_p.S255N|PPFIA4_ENST00000447715.2_Missense_Mutation_p.S739N|PPFIA4_ENST00000295706.4_Missense_Mutation_p.S255N			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	255					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						AGCAGCAACAGCAGCCAGGAC	0.582													12	14					0	0	1	0	0	A	203025953	G	A	203025953	3	1	21	1	0	0	0	0	1	0	0	0	12356	971	34	3	786	3	PPFIA4	1	203025953	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6226263	203025953	46224668	50	1471										
ZC3H11A	9877	broad.mit.edu	37	chr1	203819736	203819736	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcagtggagatgcacgctgCtgtcattgccgctgtgaagc	15	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:203819736C>T	ENST00000545588.1	+	15	5860	c.2033C>T	c.(2032-2034)gCt>gTt	p.A678V	ZC3H11A_ENST00000367210.1_Missense_Mutation_p.A678V|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.A678V|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.A678V|ZC3H11A_ENST00000367214.1_Missense_Mutation_p.A678V	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	678							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGCACGCTGCTGTCATTGCC	0.502													29	40					0	0	1	0	0	T	203819736	C	T	203819736	3	4	21	1	0	0	0	0	1	0	0	0	17618	797	28	3	2087	3	ZC3H11A	1	203819736	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	793783	203819736	45430885	51	1472										
NUAK2	81788	broad.mit.edu	37	chr1	205290640	205290640	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgtggtggtgccgcttcacCgcctgcttcttcattagggg	13	11	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:205290640C>T	ENST00000367157.3	-	1	243	c.117G>A	c.(115-117)gcG>gcA	p.A39A		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	39					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCCGCTTCACCGCCTGCTTCT	0.672													3	45					0	0	1	0	0	T	205290640	C	T	205290640	2	4	21	1	0	0	0	0	0	0	0	1	10760	639	23	1		1	NUAK2	1	205290640	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1470904	205290640	43959981	52	1473										
USH2A	7399	broad.mit.edu	37	chr1	215853543	215853543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accactgtagtagcaatgccCggccattctctttctgttct	7	13	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:215853543C>T	ENST00000366943.2	-	62	12628	c.12242G>A	c.(12241-12243)cGg>cAg	p.R4081Q	USH2A_ENST00000307340.3_Missense_Mutation_p.R4081Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4081	Fibronectin type-III 26.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGCAATGCCCGGCCATTCTC	0.408										HNSCC(13;0.011)			47	74					0	0	1	0	0	T	215853543	C	T	215853543	3	4	21	1	0	0	0	0	1	0	0	0	17095	652	23	1	3410	1	USH2A	1	215853543	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	10562903	215853543	33397078	53	1474										
LIN9	286826	broad.mit.edu	37	chr1	226453981	226453981	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcataaaaaatcgagaaggcCgctgtttttgtccaaaggca	9	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:226453981C>A	ENST00000328205.5	-	9	1462	c.917G>T	c.(916-918)cGg>cTg	p.R306L	LIN9_ENST00000481685.1_Missense_Mutation_p.R271L|LIN9_ENST00000366801.1_Missense_Mutation_p.R255L	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	290					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		TCGAGAAGGCCGCTGTTTTTG	0.338													15	11					0.000308642	0.000313286	1	1	0	A	226453981	C	A	226453981	3	1	21	1	0	0	0	0	1	0	0	0	8853	652	23	5	787	5	LIN9	1	226453981	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	10600438	226453981	22796640	54	1475										
JMJD4	65094	broad.mit.edu	37	chr1	227922791	227922791	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccggctgccccagccctgcgTgaaggcgctggaaaacacgc	13	16	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:227922791T>C	ENST00000366758.3	-	1	321	c.322A>G	c.(322-324)Acg>Gcg	p.T108A	SNAP47_ENST00000366759.4_5'UTR|SNAP47_ENST00000315781.5_5'UTR|JMJD4_ENST00000438896.2_Missense_Mutation_p.T108A|SNAP47_ENST00000366760.1_Intron	NM_023007.2	NP_075383.2	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4	108										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	9		Prostate(94;0.0885)				CAGCCCTGCGTGAAGGCGCTG	0.721													4	16					0	0	1	0	0	C	227922791	T	C	227922791	3	2	21	1	0	0	0	0	1	0	0	0	7994	1696	59	4	1093	4	JMJD4	1	227922791	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1468810	227922791	21327830	55	1476										
OBSCN	84033	broad.mit.edu	37	chr1	228474715	228474715	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtgaggctgggggcgcctgCagcagctccattgtcagggt	17	10	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:228474715C>T	ENST00000570156.2	+	40	10880	c.10806C>T	c.(10804-10806)tgC>tgT	p.C3602C	OBSCN_ENST00000366709.4_Silent_p.C292C|OBSCN_ENST00000284548.11_Silent_p.C3173C|OBSCN_ENST00000359599.6_Silent_p.C2020C|OBSCN_ENST00000422127.1_Silent_p.C3173C|OBSCN_ENST00000366707.4_Silent_p.C292C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2635	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGGCGCCTGCAGCAGCTCCA	0.652													3	9					0	0	1	0	0	T	228474715	C	T	228474715	2	4	21	1	0	0	0	0	0	0	0	1	10859	718	25	3		3	OBSCN	1	228474715	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	551924	228474715	20775906	56	1477										
CAPN9	10753	broad.mit.edu	37	chr1	230907846	230907846	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacgggtcgtggagcgacagGtcagtcaccctatcctgcct	12	13	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:230907846G>A	ENST00000354537.1	+	7	957		c.e7+1		CAPN9_ENST00000366666.2_Splice_Site|CAPN9_ENST00000271971.2_Splice_Site|RP11-99J16__A.2_ENST00000412344.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9						digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GGAGCGACAGGTCAGTCACCC	0.597													37	57					0	0	1	0	0	A	230907846	G	A	230907846	5	1	21	1	0	0	0	0	0	0	1	0	2650	1275	44	3	902	3	CAPN9	1	230907846	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2433131	230907846	18342775	57	1478										
FMN2	56776	broad.mit.edu	37	chr1	240601375	240601375	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgacagctttttggagaccaCggcatatttcttcatgaaac	8	9	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:240601375C>T	ENST00000319653.9	+	16	5155	c.4925C>T	c.(4924-4926)aCg>aTg	p.T1642M	FMN2_ENST00000545751.1_Missense_Mutation_p.T238M	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1642	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTGGAGACCACGGCATATTTC	0.378													38	77					0	0	1	0	0	T	240601375	C	T	240601375	3	4	21	1	0	0	0	0	1	0	0	0	5982	536	19	1	4987	1	FMN2	1	240601375	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	9693529	240601375	8649246	58	1479										
RGS7	6000	broad.mit.edu	37	chr1	241033369	241033369	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acttacagcctcatagtctgCgagctccagtcgtgccttgt	9	13	2	0	rs149172715	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:241033369C>T	ENST00000366565.1	-	7	817	c.436G>A	c.(436-438)Gca>Aca	p.A146T	RGS7_ENST00000401882.1_Missense_Mutation_p.A93T|RGS7_ENST00000366563.1_Missense_Mutation_p.A146T|RGS7_ENST00000446183.2_Missense_Mutation_p.A62T|RGS7_ENST00000366562.4_Missense_Mutation_p.A146T|RGS7_ENST00000366564.1_Missense_Mutation_p.A146T|RGS7_ENST00000348120.2_Missense_Mutation_p.A93T|RGS7_ENST00000331110.7_Missense_Mutation_p.A120T|RGS7_ENST00000407727.1_Missense_Mutation_p.A146T	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	146					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCATAGTCTGCGAGCTCCAGT	0.458													30	44					0	0	1	0	0	T	241033369	C	T	241033369	3	4	21	1	0	0	0	0	1	0	0	0	13359	768	27	1	1075	1	RGS7	1	241033369	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	431994	241033369	8217252	59	1480										
OR2L2	26246	broad.mit.edu	37	chr1	248201969	248201969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcctctccactatcccatcCgtataagcaaaagagtgtgt	6	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:248201969C>T	ENST00000366479.2	+	1	496	c.400C>T	c.(400-402)Cgt>Tgt	p.R134C	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTATCCCATCCGTATAAGCAA	0.428													53	70					0	0	1	0	0	T	248201969	C	T	248201969	3	4	21	1	0	0	0	0	1	0	0	0	11054	652	23	1	402	1	OR2L2	1	248201969	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7168600	248201969	1048652	60	1481										
ROCK2	9475	broad.mit.edu	37	chr2	11332603	11332603	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaggtgctataatctcctccTttttgtccatatgatcttta							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:11332603delT	ENST00000315872.6	-	31	4371	c.3923delA	c.(3922-3924)agfs	p.K1308fs	ROCK2_ENST00000401753.1_Frame_Shift_Del_p.K1065fs	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1308	PH.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AATCTCCTCCTTTTTGTCCAT	0.388													34	64	---	---	---	---						-	11332603	T	-	11332603	7	5	21	1	0	1	0	1	0	0	0	0	13569	1609	56	0	255	0	ROCK2	2	11332603	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08		11332603	231866770	61	1482										
RAD51AP2	729475	broad.mit.edu	37	chr2	17698825	17698825	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaatccctaacatatgcctcTtttttgtcattctttttctt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:17698825delT	ENST00000399080.2	-	1	881	c.858delA	c.(856-858)aafs	p.K286fs		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	286										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CATATGCCTCTTTTTTGTCAT	0.353													17	31	---	---	---	---						-	17698825	T	-	17698825	7	5	21	1	0	1	0	1	0	0	0	0	13038	1606	56	0	2633	0	RAD51AP2	2	17698825	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	6366222	17698825	225500548	62	1483										
NCOA1	8648	broad.mit.edu	37	chr2	24905856	24905856	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctttgttgtgaactgtgaaGggagaattgtatttgtgtca	12	3	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:24905856G>T	ENST00000405141.1	+	9	1102	c.391G>T	c.(391-393)Ggg>Tgg	p.G131W	NCOA1_ENST00000348332.3_Missense_Mutation_p.G131W|NCOA1_ENST00000407230.1_5'UTR|NCOA1_ENST00000406961.1_Missense_Mutation_p.G131W|NCOA1_ENST00000288599.5_Missense_Mutation_p.G131W|NCOA1_ENST00000538539.1_Missense_Mutation_p.G131W|NCOA1_ENST00000395856.3_Missense_Mutation_p.G131W			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	131	PAS.							p.G131W(1)	PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAACTGTGAAGGGAGAATTGT	0.368			T	PAX3	alveolar rhadomyosarcoma								18	41					2.37509e-13	2.54019e-13	1	1	0	T	24905856	G	T	24905856	3	4	21	1	0	0	0	0	1	0	0	0	10274	1000	35	5	405	5	NCOA1	2	24905856	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7207031	24905856	218293517	63	1484										
ADCY3	109	broad.mit.edu	37	chr2	25050931	25050931	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcgatgagggacagcacggCcacatagttgtaatacttgg	14	8	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:25050931C>T	ENST00000260600.5	-	13	3123	c.2272G>A	c.(2272-2274)Gcc>Acc	p.A758T	ADCY3_ENST00000450524.1_5'UTR|ADCY3_ENST00000405392.1_Intron	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	758					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GACAGCACGGCCACATAGTTG	0.597											OREG0014498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	27					0	0	1	0	0	T	25050931	C	T	25050931	3	4	21	1	0	0	0	0	1	0	0	0	294	739	26	3	1198	3	ADCY3	2	25050931	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	145075	25050931	218148442	64	1485										
ASXL2	55252	broad.mit.edu	37	chr2	25990452	25990452	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtctttgtaagcaaacttacTggtatggagtctctcagatc	9	8	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:25990452T>C	ENST00000435504.4	-	8	1068	c.775_splice	c.e8+1	p.R259_splice	ASXL2_ENST00000336112.4_Splice_Site_p.R231_splice|ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding	p.R259*(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAAACTTACTGGTATGGAGT	0.373													15	29					0	0	1	0	0	C	25990452	T	C	25990452	5	2	21	1	0	0	0	0	0	0	1	0	1066	1594	55	4	3556	4	ASXL2	2	25990452	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	939521	25990452	217208921	65	1486										
SLC5A6	8884	broad.mit.edu	37	chr2	27423872	27423872	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagcaggtactacctggccGtagctcctgcagtggagccg	13	13	0	0	rs140378947		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:27423872G>A	ENST00000310574.3	-	16	2231	c.1758C>T	c.(1756-1758)taC>taT	p.Y586Y	SLC5A6_ENST00000408041.1_Silent_p.Y586Y	NM_021095.2	NP_066918.2	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	586					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(3)|prostate(1)|skin(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	CTACCTGGCCGTAGCTCCTGC	0.592													4	23					0	0	1	0	0	A	27423872	G	A	27423872	2	1	21	1	0	0	0	0	0	0	0	1	14723	1140	40	1		1	SLC5A6	2	27423872	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1433420	27423872	215775501	66	1487										
ALK	238	broad.mit.edu	37	chr2	29449848	29449848	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtcacagaagcagatgacctTgtggctttcagggtccatgt	12	9	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:29449848T>C	ENST00000389048.3	-	18	3913	c.3007A>G	c.(3007-3009)Aag>Gag	p.K1003E	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1003					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CAGATGACCTTGTGGCTTTCA	0.557			"T, Mis, A"	"NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"	"ALCL, NSCLC, Neuroblastoma"	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				58	143					0	0	1	0	0	C	29449848	T	C	29449848	3	2	21	1	0	0	0	0	1	0	0	0	521	1821	63	4	1903	4	ALK	2	29449848	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2025976	29449848	213749525	67	1488										
BIRC6	57448	broad.mit.edu	37	chr2	32768513	32768513	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcttttggattatttcttcGtcttccgggctatgcggaag	11	8	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:32768513G>A	ENST00000421745.2	+	62	12631	c.12497G>A	c.(12496-12498)cGt>cAt	p.R4166H		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4166					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TTATTTCTTCGTCTTCCGGGC	0.483													92	132					0	0	1	0	0	A	32768513	G	A	32768513	3	1	21	1	0	0	0	0	1	0	0	0	1437	1145	40	1	12743	1	BIRC6	2	32768513	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3318665	32768513	210430860	68	1489										
PRKD3	23683	broad.mit.edu	37	chr2	37506904	37506904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	attacctgattgttttaacgGcttcttcatctctttccaca	4	11	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:37506904G>A	ENST00000379066.1	-	8	1919	c.1157C>T	c.(1156-1158)gCc>gTc	p.A386V	PRKD3_ENST00000234179.2_Missense_Mutation_p.A386V			O94806	KPCD3_HUMAN	protein kinase D3	386					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				TGTTTTAACGGCTTCTTCATC	0.408													21	58					0	0	1	0	0	A	37506904	G	A	37506904	3	1	21	1	0	0	0	0	1	0	0	0	12571	1203	42	3	1563	3	PRKD3	2	37506904	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4738391	37506904	205692469	69	1490										
DHX57	90957	broad.mit.edu	37	chr2	39088332	39088332	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggttatcaaagaatatacgAcaggttccgaagtttccgca	10	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:39088332A>T	ENST00000295373.6	-	5	1346	c.1220T>A	c.(1219-1221)gTc>gAc	p.V407D	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	407							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				AGAATATACGACAGGTTCCGA	0.403													53	69					0	0	1	0	0	T	39088332	A	T	39088332	3	4	21	1	0	0	0	0	1	0	0	0	4541	275	10	4	3020	4	DHX57	2	39088332	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1581428	39088332	204111041	70	1491										
ZFP36L2	678	broad.mit.edu	37	chr2	43451501	43451501	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctgaagattggcaggcggCggccagggtcgaggctggga	21	8	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:43451501C>T	ENST00000282388.3	-	2	1735	c.1442G>A	c.(1441-1443)cGc>cAc	p.R481H	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	481					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				TGGCAGGCGGCGGCCAGGGTC	0.667													7	9					0	0	1	0	0	T	43451501	C	T	43451501	3	4	21	1	0	0	0	0	1	0	0	0	17704	768	27	1	46	1	ZFP36L2	2	43451501	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4363169	43451501	199747872	71	1492										
ZFP36L2	678	broad.mit.edu	37	chr2	43452260	43452260	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cacgcaggtccccggaggcgCcccccgacggcgcgggccgc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:43452260delC	ENST00000282388.3	-	2	976	c.683delG	c.(682-684)gcfs	p.G228fs	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	228					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CCCGGAggcgccccccgacgg	0.706													16	31	---	---	---	---						-	43452260	C	-	43452260	7	5	21	1	0	1	0	1	0	0	0	0	17704	739	26	0	805	0	ZFP36L2	2	43452260	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	759	43452260	199747113	72	1493										
ABCG8	64241	broad.mit.edu	37	chr2	44105047	44105047	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacagaaaccaagtcaagacTggtgattcacgccagacgtc	9	11	2	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:44105047T>C	ENST00000272286.2	+	13	2107	c.2017T>C	c.(2017-2019)Tgg>Cgg	p.W673R		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	673					cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AAGTCAAGACTGGTGATTCAC	0.562											OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	32					0	0	1	0	0	C	44105047	T	C	44105047	3	2	21	1	0	0	0	0	1	0	0	0	72	1580	55	4	2067	4	ABCG8	2	44105047	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	652787	44105047	199094326	73	1494										
MSH2	4436	broad.mit.edu	37	chr2	47707956	47707956	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttcagtatattggagaatcGcaaggatatgatatcatgga	10	4	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:47707956G>A	ENST00000406134.1	+	15	2642	c.2580G>A	c.(2578-2580)tcG>tcA	p.S860S	MSH2_ENST00000543555.1_Silent_p.S794S|MSH2_ENST00000461394.1_3'UTR|MSH2_ENST00000233146.2_Silent_p.S860S			P43246	MSH2_HUMAN	mutS homolog 2	860					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(2)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTGGAGAATCGCAAGGATATG	0.383			"D, Mis, N, F, S"		"colorectal, endometrial, ovarian"	"colorectal, endometrial, ovarian"		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				56	64					0	0	1	0	0	A	47707956	G	A	47707956	2	1	21	1	0	0	0	0	0	0	0	1	9918	1074	38	1		1	MSH2	2	47707956	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3602909	47707956	195491417	74	1495										
ANTXR1	84168	broad.mit.edu	37	chr2	69472531	69472531	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccctcccatcccgtccccaCcttccacccttccccctcct	1	28	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:69472531C>T	ENST00000303714.4	+	18	1931	c.1609C>T	c.(1609-1611)Cct>Tct	p.P537S		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	537	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						cccgtccccaccttccaccct	0.706									Familial Infantile Hemangioma				3	6					0	0	1	0	0	T	69472531	C	T	69472531	3	4	21	1	0	0	0	0	1	0	0	0	705	507	18	3	1756	3	ANTXR1	2	69472531	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	21764575	69472531	173726842	75	1496										
GFPT1	2673	broad.mit.edu	37	chr2	69554051	69554051	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggtagatgacttacatcatAgcctctcagcacagcaaggt	9	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:69554051A>G	ENST00000357308.4	-	19	2228	c.2050T>C	c.(2050-2052)Tat>Cat	p.Y684H	GFPT1_ENST00000361060.4_Missense_Mutation_p.Y666H	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	684	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						CTTACATCATAGCCTCTCAGC	0.433													25	22					0	0	1	0	0	G	69554051	A	G	69554051	3	3	21	1	0	0	0	0	1	0	0	0	6386	420	15	4	57	4	GFPT1	2	69554051	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	81520	69554051	173645322	76	1497										
ANXA4	307	broad.mit.edu	37	chr2	70035051	70035051	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtttagggagccggcactgAtgagggctgcctaattgaga	15	7	0	3	rs139920396		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:70035051A>G	ENST00000394295.4	+	6	568	c.320A>G	c.(319-321)gAt>gGt	p.D107G	ANXA4_ENST00000536030.1_Missense_Mutation_p.D23G|ANXA4_ENST00000409920.1_Missense_Mutation_p.D85G	NM_001153.3	NP_001144.1	P09525	ANXA4_HUMAN	annexin A4	105					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11						GCCGGCACTGATGAGGGCTGC	0.552													28	41					0	0	1	0	0	G	70035051	A	G	70035051	3	3	21	1	0	0	0	0	1	0	0	0	714	333	12	4	338	4	ANXA4	2	70035051	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	481000	70035051	173164322	77	1498										
ASPRV1	151516	broad.mit.edu	37	chr2	70188284	70188284	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atctctttgggcaggtggctGggggcagccccagggacccc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:70188284delG	ENST00000320256.4	-	1	1113	c.537delC	c.(535-537)ccfs	p.P179fs		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	179					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity	p.P179P(1)		endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						GCAGGTGGCTGGGGGCAGCCC	0.587													51	48	---	---	---	---						-	70188284	G	-	70188284	7	5	21	1	0	1	0	1	0	0	0	0	1057	1335	47	0	498	0	ASPRV1	2	70188284	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	153233	70188284	173011089	78	1499										
C2orf42	54980	broad.mit.edu	37	chr2	70392681	70392682	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtggtggagttggggagccgINStttttttgcacttcctatag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:70392681_70392682insT	ENST00000264434.2	-	7	1609_1610	c.1230_1231insA	c.(1228-1233)aaggctfs	p.A411fs	C2orf42_ENST00000420306.1_Frame_Shift_Ins_p.A411fs	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	411										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						TTGGGGAGCCGTTTTTTTGCAC	0.406													29	57	---	---	---	---						T	70392682	-	T	70392681	7	5	21	1	0	1	1	0	0	0	0	0	2180	1144	40	0	509	0	C2orf42	2	70392681	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	204397	70392681	172806692	79	1500										
FBXO41	150726	broad.mit.edu	37	chr2	73490910	73490910	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgcgcaggatcagcaggttCcccccagctgccttcagcag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:73490910delC	ENST00000521871.1	-	8	2386	c.1971delG	c.(1969-1971)ggfs	p.G657fs	FBXO41_ENST00000295133.5_Frame_Shift_Del_p.G718fs|FBXO41_ENST00000520530.2_Frame_Shift_Del_p.G657fs			Q8TF61	FBX41_HUMAN	F-box protein 41	657						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						TCAGCAGGTTCCCCCCAGCTG	0.637													13	102	---	---	---	---						-	73490910	C	-	73490910	7	5	21	1	0	1	0	1	0	0	0	0	5782	842	30	0	680	0	FBXO41	2	73490910	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3098229	73490910	169708463	80	1501										
HK2	3099	broad.mit.edu	37	chr2	75113749	75113749	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgcctagatgacttccgcaCagaatttgatgtggctgtgg	12	8	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:75113749C>T	ENST00000290573.2	+	15	2768	c.2168C>T	c.(2167-2169)aCa>aTa	p.T723I	HK2_ENST00000409174.1_Missense_Mutation_p.T695I	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	723	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GACTTCCGCACAGAATTTGAT	0.562													54	80					0	0	1	0	0	T	75113749	C	T	75113749	3	4	21	1	0	0	0	0	1	0	0	0	7231	478	17	3	2226	3	HK2	2	75113749	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1622839	75113749	168085624	81	1502										
SUCLG1	8802	broad.mit.edu	37	chr2	84670463	84670463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgtctggcctcctttccctGgagtggttcctccaacgagt	11	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:84670463G>A	ENST00000393868.2	-	3	473	c.263C>T	c.(262-264)cCa>cTa	p.P88L		NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	88					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	TCCTTTCCCTGGAGTGGTTCC	0.488													5	96					0	0	1	0	0	A	84670463	G	A	84670463	3	1	21	1	0	0	0	0	1	0	0	0	15419	1348	47	3	805	3	SUCLG1	2	84670463	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9556714	84670463	158528910	82	1503										
FER1L5	90342	broad.mit.edu	37	chr2	97363350	97363350	+	RNA	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccattcagtgcagggaggtGgggggctgcccctgcccgag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:97363350delG	ENST00000457909.1	+	0	3637							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						GCAGGGAGGTGGGGGGCTGCC	0.547													16	20	---	---	---	---						-	97363350	G	-	97363350	6	5	21	0	1	1	0	1	0	0	0	0	5846	1363	47	0		0	FER1L5	2	97363350	RNA	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	12692887	97363350	145836023	83	1504										
TGFBRAP1	9392	broad.mit.edu	37	chr2	105924173	105924173	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaacaggtcctgggagacgcCtgtgctgtaattgtggatga	14	7	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:105924173C>A	ENST00000393359.2	-	2	1012	c.586G>T	c.(586-588)Ggc>Tgc	p.G196C	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.G196C			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	196	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						TGGGAGACGCCTGTGCTGTAA	0.622													94	126					1.63847e-34	1.83751e-34	1	1	0	A	105924173	C	A	105924173	3	1	21	1	0	0	0	0	1	0	0	0	15883	681	24	5	2040	5	TGFBRAP1	2	105924173	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	8560823	105924173	137275200	84	1505										
SEPT10	151011	broad.mit.edu	37	chr2	110301827	110301828	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaatcaaagcacacttctagINStttttttttaataaagtttg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:110301827_110301828insT	ENST00000356688.4	-	12	1821_1822	c.1506_1507insA	c.(1504-1509)aatagafs	p.NR502fs	SEPT10_ENST00000437928.1_3'UTR|SEPT10_ENST00000334001.6_3'UTR|SEPT10_ENST00000397714.2_3'UTR|SEPT10_ENST00000397712.2_3'UTR			Q9P0V9	SEP10_HUMAN	septin 10	0					cell cycle|cell division	septin complex	GTP binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|prostate(1)	18						CACACTTCTAGTTTTTTTTTAA	0.317													20	28	---	---	---	---						T	110301828	-	T	110301827	7	5	21	1	0	1	1	0	0	0	0	0	14113	1044	36	0		0	SEPT10	2	110301827	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	4377654	110301827	132897546	85	1506										
MERTK	10461	broad.mit.edu	37	chr2	112786408	112786408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gatgaacttttgtttgctgaCgactcctcagaaggctcaga	10	9	2	4	rs140956730		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:112786408C>T	ENST00000295408.4	+	19	3224	c.2967C>T	c.(2965-2967)gaC>gaT	p.D989D	MERTK_ENST00000409780.1_Silent_p.D813D|MERTK_ENST00000421804.2_Silent_p.D989D			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	989					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TGTTTGCTGACGACTCCTCAG	0.502													25	29					0	0	1	0	0	T	112786408	C	T	112786408	2	4	21	1	0	0	0	0	0	0	0	1	9528	535	19	1		1	MERTK	2	112786408	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2484581	112786408	130412965	86	1507										
ZC3H6	376940	broad.mit.edu	37	chr2	113067600	113067600	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgatgacaactttggtaacTacggtcaggaaacagaggaa	12	6	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:113067600T>C	ENST00000409871.1	+	4	876	c.475T>C	c.(475-477)Tac>Cac	p.Y159H	ZC3H6_ENST00000343936.4_Missense_Mutation_p.Y159H	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	159							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						CTTTGGTAACTACGGTCAGGA	0.363													10	19					0	0	1	0	0	C	113067600	T	C	113067600	3	2	21	1	0	0	0	0	1	0	0	0	17629	1522	53	4	489	4	ZC3H6	2	113067600	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	281192	113067600	130131773	87	1508										
PCDP1	0	broad.mit.edu	37	chr2	120388230	120388230	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagacctcaaaagcttgccCgagccctaaagcaaggagct	9	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:120388230C>T	ENST00000602047.1	+	19	2070	c.958C>T	c.(958-960)Cga>Tga	p.R320*	PCDP1_ENST00000413369.3_Nonsense_Mutation_p.R606*			Q4G0U5	PCDP1_HUMAN		606						cilium	calmodulin binding					Colorectal(110;0.196)					AAAGCTTGCCCGAGCCCTAAA	0.448													27	31					0	0	1	0	0	T	120388230	C	T	120388230	4	4	21	1	0	0	0	0	0	1	0	0	11618	644	23	1	996	1	PCDP1	2	120388230	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7320630	120388230	122811143	88	1509										
TMEM177	80775	broad.mit.edu	37	chr2	120438732	120438732	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcccaagactccctgctggGgctgtggtgggcatccctgc	13	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:120438732G>T	ENST00000424086.1	+	2	776	c.303G>T	c.(301-303)ggG>ggT	p.G101G	TMEM177_ENST00000409951.1_Intron|TMEM177_ENST00000272521.6_Silent_p.G101G|TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000401466.1_Silent_p.G101G	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	101						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					TCCCTGCTGGGGCTGTGGTGG	0.562													145	225					6.07058e-49	6.87843e-49	1	1	0	T	120438732	G	T	120438732	2	4	21	1	0	0	0	0	0	0	0	1	16153	1219	43	5		5	TMEM177	2	120438732	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	50502	120438732	122760641	89	1510										
WDR33	55339	broad.mit.edu	37	chr2	128471558	128471558	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcatgccgcctctctgacatCgggcccatgtgatggtttgg	12	12	2	2	rs151283651		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:128471558C>T	ENST00000322313.4	-	18	3065	c.2907G>A	c.(2905-2907)ccG>ccA	p.P969P		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	969					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCTCTGACATCGGGCCCATGT	0.612													14	39					0	0	1	0	0	T	128471558	C	T	128471558	2	4	21	1	0	0	0	0	0	0	0	1	17346	871	31	1		1	WDR33	2	128471558	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	8032826	128471558	114727815	90	1511										
FAM168B	130074	broad.mit.edu	37	chr2	131812977	131812977	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caccgtggtgtggtggatgaCgtgaggaggtgctgcataca	17	7	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:131812977C>T	ENST00000409185.1	-	5	450	c.343G>A	c.(343-345)Gtc>Atc	p.V115I	FAM168B_ENST00000389915.3_Missense_Mutation_p.V115I	NM_001009993.2	NP_001009993.2	A1KXE4	F168B_HUMAN	family with sequence similarity 168, member B	115										endometrium(3)|lung(2)	5						TGGTGGATGACGTGAGGAGGT	0.612													59	106					0	0	1	0	0	T	131812977	C	T	131812977	3	4	21	1	0	0	0	0	1	0	0	0	5515	536	19	1	252	1	FAM168B	2	131812977	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3341419	131812977	111386396	91	1512										
TUBA3D	113457	broad.mit.edu	37	chr2	132236920	132236920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctacaggcagctcttccaccCggagcagctgatcaccggga	11	15	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:132236920C>T	ENST00000321253.6	+	3	373	c.266C>T	c.(265-267)cCg>cTg	p.P89L	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	89					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTCTTCCACCCGGAGCAGCTG	0.527													68	113					0	0	1	0	0	T	132236920	C	T	132236920	3	4	21	1	0	0	0	0	1	0	0	0	16808	652	23	1	276	1	TUBA3D	2	132236920	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	423943	132236920	110962453	92	1513										
NCKAP5	344148	broad.mit.edu	37	chr2	133541791	133541791	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgggcggaatgttttggaaTgtgtggatctgatcgtaatt	14	3	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:133541791T>C	ENST00000409261.1	-	14	2966	c.2593A>G	c.(2593-2595)Att>Gtt	p.I865V	NCKAP5_ENST00000317721.6_Missense_Mutation_p.I865V|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	865							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TGTTTTGGAATGTGTGGATCT	0.537													42	71					0	0	1	0	0	C	133541791	T	C	133541791	3	2	21	1	0	0	0	0	1	0	0	0	10269	1464	51	4	3164	4	NCKAP5	2	133541791	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1304871	133541791	109657582	93	1514										
NCKAP5	344148	broad.mit.edu	37	chr2	133543031	133543031	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccaggtcagctgttttgcaGgggggatactccttgaggct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:133543031delG	ENST00000409261.1	-	14	1726	c.1353delC	c.(1351-1353)ccfs	p.P451fs	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000317721.6_Frame_Shift_Del_p.P451fs	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	451							protein binding	p.C452fs*21(1)		NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTGTTTTGCAGGGGGGATACT	0.463													24	21	---	---	---	---						-	133543031	G	-	133543031	7	5	21	1	0	1	0	1	0	0	0	0	10269	987	35	0	4404	0	NCKAP5	2	133543031	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1240	133543031	109656342	94	1515										
MGAT5	4249	broad.mit.edu	37	chr2	135119889	135119889	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggggtttgtggttgagcaGcacctgaactccagtgatat	13	8	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:135119889G>A	ENST00000409645.1	+	11	1542	c.1290G>A	c.(1288-1290)caG>caA	p.Q430Q	MGAT5_ENST00000281923.2_Silent_p.Q430Q			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	430					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		TGGTTGAGCAGCACCTGAACT	0.458													86	119					0	0	1	0	0	A	135119889	G	A	135119889	2	1	21	1	0	0	0	0	0	0	0	1	9597	962	34	3		3	MGAT5	2	135119889	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1576858	135119889	108079484	95	1516										
R3HDM1	23518	broad.mit.edu	37	chr2	136409480	136409482	+	In_Frame_Del	DEL	CCT	CCT	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctccaccgccaccaccaccaCctcctcctcctcccctacca					rs139457585		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:136409480_136409482delCCT	ENST00000264160.4	+	17	2171_2173	c.1801_1803delCCT	c.(1801-1803)del	p.P605del	R3HDM1_ENST00000329971.3_In_Frame_Del_p.P476del|R3HDM1_ENST00000409606.1_In_Frame_Del_p.P606del|R3HDM1_ENST00000410054.1_In_Frame_Del_p.P550del|R3HDM1_ENST00000409478.1_In_Frame_Del_p.P477del	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	605	Poly-Pro.						nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		accaccaccacctcctcctcctc	0.586													38	71	---	---	---	---						-	136409482	CCT	-	136409480	7	5	21	1	0	1	0	1	0	0	0	0	12938	507	18	0	1859	0	R3HDM1	2	136409480	In_Frame_Del	DEL	CCT	TCGA-N7-A4Y0-01A-12D-A28R-08	1289591	136409480	106789893	96	1517										
LCT	3938	broad.mit.edu	37	chr2	136566315	136566315	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgttgaggcagaagacgtcgGccgtcgccctgatgaacctc	13	12	0	5			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:136566315G>A	ENST00000264162.2	-	8	3612	c.3602C>T	c.(3601-3603)gCc>gTc	p.A1201V		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1201	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAAGACGTCGGCCGTCGCCCT	0.557													96	115					0	0	1	0	0	A	136566315	G	A	136566315	3	1	21	1	0	0	0	0	1	0	0	0	8731	1203	42	3	2221	3	LCT	2	136566315	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	156835	136566315	106633058	97	1518										
LRP1B	53353	broad.mit.edu	37	chr2	141819647	141819648	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttgaatgacagtgtgtctaINSttttttccttgatagtccac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:141819647_141819648insT	ENST00000389484.3	-	8	2179_2180	c.1208_1209insA	c.(1207-1209)aagfs	p.K403fs		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	403					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTGTGTCTATTTTTTCCTTG	0.391										TSP Lung(27;0.18)			35	78	---	---	---	---						T	141819648	-	T	141819647	7	5	21	1	0	1	1	0	0	0	0	0	8999	446	16	0	12926	0	LRP1B	2	141819647	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	5253332	141819647	101379726	98	1519										
GRB14	2888	broad.mit.edu	37	chr2	165350964	165350964	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tataatttgaaagtgctttaTtttttgtccatgactcattg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:165350964delT	ENST00000263915.3	-	13	1991	c.1453delA	c.(1453-1455)tafs	p.I485fs	GRB14_ENST00000543549.1_Frame_Shift_Del_p.I398fs|GRB14_ENST00000497306.1_Intron	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	485	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						AAGTGCTTTATTTTTTGTCCA	0.333													26	48	---	---	---	---						-	165350964	T	-	165350964	7	5	21	1	0	1	0	1	0	0	0	0	6797	1493	52	0	177	0	GRB14	2	165350964	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	23531317	165350964	77848409	99	1520										
SCRN3	79634	broad.mit.edu	37	chr2	175292598	175292598	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aattcaaatttatcagtcaaAtttatcagtcaaagttagtt	4	5	5	0	rs76634317		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:175292598A>G	ENST00000272732.6	+	8	1332	c.1250A>G	c.(1249-1251)aAt>aGt	p.N417S	SCRN3_ENST00000409673.3_Missense_Mutation_p.N410S|SCRN3_ENST00000548921.1_3'UTR	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	417					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TATCAGTCAAATTTATCAGTC	0.323													13	21					0	0	1	0	0	G	175292598	A	G	175292598	3	3	21	1	0	0	0	0	1	0	0	0	13993	101	4	4	1276	4	SCRN3	2	175292598	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	9941634	175292598	67906775	100	1521										
HOXD1	3231	broad.mit.edu	37	chr2	177053603	177053603	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgacgtgctcagcttggcacCcaagttctgccgctccgacg	11	16	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:177053603C>G	ENST00000331462.4	+	1	297	c.74C>G	c.(73-75)cCc>cGc	p.P25R	HOXD-AS1_ENST00000413969.1_RNA	NM_024501.1	NP_078777.1	Q9GZZ0	HXD1_HUMAN	homeobox D1	25						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)		AGCTTGGCACCCAAGTTCTGC	0.706													10	15					0	0	1	0	0	G	177053603	C	G	177053603	3	3	21	1	0	0	0	0	1	0	0	0	7358	623	22	5	76	5	HOXD1	2	177053603	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1761005	177053603	66145770	101	1522										
DFNB59	494513	broad.mit.edu	37	chr2	179325760	179325760	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagctttacttggatgatcTtttttctgactactatgaca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:179325760delT	ENST00000409117.3	+	7	1174	c.818delT	c.(817-819)ctfs	p.L273fs	DFNB59_ENST00000375129.4_Frame_Shift_Del_p.L273fs	NM_001042702.3	NP_001036167.1	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	273					sensory perception of sound			p.L273P(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TTGGATGATCTTTTTTCTGAC	0.348													20	153	---	---	---	---						-	179325760	T	-	179325760	7	5	21	1	0	1	0	1	0	0	0	0	4484	1609	56	0	840	0	DFNB59	2	179325760	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2272157	179325760	63873613	102	1523										
TTN	7273	broad.mit.edu	37	chr2	179438269	179438269	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catatttatttacagccatgAcacggaatatgtattcattg	6	7	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:179438269A>G	ENST00000589042.1	-	326	72814	c.72590T>C	c.(72589-72591)gTc>gCc	p.V24197A	TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V15257A|TTN_ENST00000342992.6_Missense_Mutation_p.V21629A|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V15324A|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V15132A|TTN_ENST00000591111.1_Missense_Mutation_p.V22556A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22556	Ig-like 121.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAGCCATGACACGGAATAT	0.453													81	158					0	0	1	0	0	G	179438269	A	G	179438269	3	3	21	1	0	0	0	0	1	0	0	0	16796	275	10	4	35537	4	TTN	2	179438269	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	112509	179438269	63761104	103	1524										
TTN	7273	broad.mit.edu	37	chr2	179575969	179575969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccgtctttataccaagacaCggagataggttctgatccac	9	11	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:179575969C>T	ENST00000589042.1	-	97	28218	c.27994G>A	c.(27994-27996)Gtg>Atg	p.V9332M	TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V8088M|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V9015M|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9015	Ig-like 76.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACCAAGACACGGAGATAGGT	0.393													63	124					0	0	1	0	0	T	179575969	C	T	179575969	3	4	21	1	0	0	0	0	1	0	0	0	16796	536	19	1	76599	1	TTN	2	179575969	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	137700	179575969	63623404	104	1525										
ANKAR	150709	broad.mit.edu	37	chr2	190606079	190606079	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aatttatagggaatttaataGcaagcctggctcattctaga	8	6	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:190606079G>C	ENST00000520309.1	+	20	3800	c.3712G>C	c.(3712-3714)Gca>Cca	p.A1238P	ANKAR_ENST00000313581.4_Missense_Mutation_p.A1238P|ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000431575.2_Missense_Mutation_p.A1167P	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1238						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GAATTTAATAGCAAGCCTGGC	0.338													25	42					0	0	1	0	0	C	190606079	G	C	190606079	3	2	21	1	0	0	0	0	1	0	0	0	619	971	34	5	3786	5	ANKAR	2	190606079	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	11030110	190606079	52593294	105	1526										
DNAH7	56171	broad.mit.edu	37	chr2	196788373	196788374	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtcagagtcatcgctaataINStttttttttacaagtgatga					rs34468832		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:196788373_196788374insT	ENST00000312428.6	-	23	3870_3871	c.3770_3771insA	c.(3769-3771)aatfs	p.N1257fs		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1257	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CATCGCTAATATTTTTTTTTAC	0.421													21	46	---	---	---	---						T	196788374	-	T	196788373	7	5	21	1	0	1	1	0	0	0	0	0	4633	446	16	0	8475	0	DNAH7	2	196788373	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	6182294	196788373	46411000	106	1527										
DNAH7	56171	broad.mit.edu	37	chr2	196922833	196922833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggatttttctttgctggccGatttatcctgtatgaaaaac	8	7	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:196922833G>A	ENST00000312428.6	-	2	123	c.23C>T	c.(22-24)tCg>tTg	p.S8L	DNAH7_ENST00000410072.1_Missense_Mutation_p.S8L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	8	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTTGCTGGCCGATTTATCCTG	0.313													31	33					0	0	1	0	0	A	196922833	G	A	196922833	3	1	21	1	0	0	0	0	1	0	0	0	4633	1059	37	1	12307	1	DNAH7	2	196922833	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	134460	196922833	46276540	107	1528										
SF3B1	23451	broad.mit.edu	37	chr2	198274672	198274672	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggggttgctccaggagtctcGcttccctttgcacgacctgg	13	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:198274672G>A	ENST00000335508.5	-	7	817	c.726C>T	c.(724-726)agC>agT	p.S242S		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	242	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CAGGAGTCTCGCTTCCCTTTG	0.512			Mis		myelodysplastic syndrome								37	54					0	0	1	0	0	A	198274672	G	A	198274672	2	1	21	1	0	0	0	0	0	0	0	1	14202	1078	38	1		1	SF3B1	2	198274672	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1351839	198274672	44924701	108	1529										
GPR1	2825	broad.mit.edu	37	chr2	207041592	207041592	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccaggctgatcactgtcaggAaaaaaacactggcaaacatg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:207041592delA	ENST00000407325.2	-	3	742	c.380delT	c.(379-381)tcfs	p.F127fs	GPR1_ENST00000437420.1_Frame_Shift_Del_p.F127fs	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	127						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		CACTGTCAGGAAAAAAACACT	0.458													55	67	---	---	---	---						-	207041592	A	-	207041592	7	5	21	1	0	1	0	1	0	0	0	0	6660	246	9	0	691	0	GPR1	2	207041592	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	8766920	207041592	36157781	109	1530										
CCDC108	255101	broad.mit.edu	37	chr2	219883883	219883883	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agccttaaaggggtgaggacGggggggatctggctcatgct	18	7	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:219883883G>A	ENST00000341552.5	-	21	3575	c.3492C>T	c.(3490-3492)ccC>ccT	p.P1164P	CCDC108_ENST00000453220.1_Silent_p.P1164P|CCDC108_ENST00000441968.1_Silent_p.P1164P	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1164						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGTGAGGACGGGGGGGATCT	0.612													39	61					0	0	1	0	0	A	219883883	G	A	219883883	2	1	21	1	0	0	0	0	0	0	0	1	2761	1103	39	1		1	CCDC108	2	219883883	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	12842291	219883883	23315490	110	1531										
CCDC108	255101	broad.mit.edu	37	chr2	219895832	219895832	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaggttgggcctcacccacAgcctgcagctggatgctgct	14	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:219895832A>G	ENST00000341552.5	-	8	1094	c.1011T>C	c.(1009-1011)gcT>gcC	p.A337A	CCDC108_ENST00000453220.1_Silent_p.A337A|CCDC108_ENST00000410037.1_Silent_p.A272A|CCDC108_ENST00000409865.3_Silent_p.A326A|CCDC108_ENST00000441968.1_Silent_p.A337A	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	337						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCACCCACAGCCTGCAGCT	0.677													4	6					0	0	1	0	0	G	219895832	A	G	219895832	2	3	21	1	0	0	0	0	0	0	0	1	2761	175	7	4		4	CCDC108	2	219895832	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	11949	219895832	23303541	111	1532										
ZFAND2B	130617	broad.mit.edu	37	chr2	220073024	220073024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgtggcttctacaagcactGtccccagcccaagtcaaacc	7	16	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:220073024G>A	ENST00000409594.1	+	5	676	c.481G>A	c.(481-483)Gtc>Atc	p.V161I	ZFAND2B_ENST00000409206.1_Missense_Mutation_p.V161I|ZFAND2B_ENST00000409217.1_Missense_Mutation_p.V161I|ZFAND2B_ENST00000444522.2_Missense_Mutation_p.V161I|ZFAND2B_ENST00000409097.1_Missense_Mutation_p.V161I|ZFAND2B_ENST00000289528.5_Missense_Mutation_p.V161I|ZFAND2B_ENST00000409336.1_Missense_Mutation_p.V161I			Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	161						endoplasmic reticulum	protein binding|zinc ion binding			endometrium(2)|kidney(4)|lung(4)|upper_aerodigestive_tract(1)	11		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TACAAGCACTGTCCCCAGCCC	0.547													22	21					0	0	1	0	0	A	220073024	G	A	220073024	3	1	21	1	0	0	0	0	1	0	0	0	17685	1377	48	3	499	3	ZFAND2B	2	220073024	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	177192	220073024	23126349	112	1533										
ABCB6	10058	broad.mit.edu	37	chr2	220077176	220077176	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtagaagcgaaacagcaggCgcaaaattgtgctcttccct	10	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:220077176C>T	ENST00000265316.3	-	14	2217	c.1901G>A	c.(1900-1902)cGc>cAc	p.R634H	ABCB6_ENST00000439002.2_Missense_Mutation_p.R588H	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	634	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAACAGCAGGCGCAAAATTGT	0.512													23	37					0	0	1	0	0	T	220077176	C	T	220077176	3	4	21	1	0	0	0	0	1	0	0	0	45	768	27	1	651	1	ABCB6	2	220077176	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4152	220077176	23122197	113	1534										
IRS1	3667	broad.mit.edu	37	chr2	227661891	227661891	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgccgagtgagttctctttcGgaaccgattatccagatctg	10	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:227661891G>A	ENST00000305123.4	-	1	2584	c.1564C>T	c.(1564-1566)Cga>Tga	p.R522*		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	522					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GTTCTCTTTCGGAACCGATTA	0.577											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	59					0	0	1	0	0	A	227661891	G	A	227661891	4	1	21	1	0	0	0	0	0	1	0	0	7883	1124	39	1	2168	1	IRS1	2	227661891	Nonsense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7584715	227661891	15537482	114	1535										
DNER	92737	broad.mit.edu	37	chr2	230223281	230223281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aatctttagttttaatcagtGtgaccaagggtttgtcatca	8	6	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:230223281G>A	ENST00000341772.4	-	13	2323	c.2189C>T	c.(2188-2190)aCa>aTa	p.T730I		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	730					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTTAATCAGTGTGACCAAGGG	0.333													32	30					0	0	1	0	0	A	230223281	G	A	230223281	3	1	21	1	0	0	0	0	1	0	0	0	4694	1377	48	3	28	3	DNER	2	230223281	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2561390	230223281	12976092	115	1536										
SP110	3431	broad.mit.edu	37	chr2	231072718	231072718	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catcttacctcctgggaggcTttttttcttatgtctccttt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:231072718delT	ENST00000258381.6	-	8	963	c.886delA	c.(886-888)gcfs	p.S296fs	SP110_ENST00000486146.2_5'UTR|SP110_ENST00000338556.3_Frame_Shift_Del_p.S48fs|SP110_ENST00000258382.5_Frame_Shift_Del_p.S296fs|SP110_ENST00000358662.4_Frame_Shift_Del_p.S296fs|SP110_ENST00000540870.1_Frame_Shift_Del_p.S302fs|SP110_ENST00000392048.3_Frame_Shift_Del_p.S296fs	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	296					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		CCTGGGAGGCTTTTTTTCTTA	0.393													3	6	---	---	---	---						-	231072718	T	-	231072718	7	5	21	1	0	1	0	1	0	0	0	0	15014	1609	56	0	1367	0	SP110	2	231072718	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	849437	231072718	12126655	116	1537										
INPP5D	3635	broad.mit.edu	37	chr2	234070428	234070428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaacaagcactcagagcagcCggagcccgacatgatcacca	10	14	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:234070428C>T	ENST00000359570.5	+	13	1160	c.1160C>T	c.(1159-1161)cCg>cTg	p.P387L	INPP5D_ENST00000455936.2_Missense_Mutation_p.P151L|INPP5D_ENST00000450745.1_Missense_Mutation_p.P151L|INPP5D_ENST00000538935.1_Missense_Mutation_p.P386L			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	399					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCAGAGCAGCCGGAGCCCGAC	0.587													13	10					0	0	1	0	0	T	234070428	C	T	234070428	3	4	21	1	0	0	0	0	1	0	0	0	7799	652	23	1	746	1	INPP5D	2	234070428	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2997710	234070428	9128945	117	1538										
HJURP	55355	broad.mit.edu	37	chr2	234750399	234750399	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acggcaagaaacatctaataCgttcttgcaatctcttaatg	6	9	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:234750399C>T	ENST00000411486.2	-	8	1092	c.1027G>A	c.(1027-1029)Gta>Ata	p.V343I	HJURP_ENST00000441687.1_Missense_Mutation_p.V258I|HJURP_ENST00000432087.1_Missense_Mutation_p.V289I	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	343					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACATCTAATACGTTCTTGCAA	0.438													20	23					0	0	1	0	0	T	234750399	C	T	234750399	3	4	21	1	0	0	0	0	1	0	0	0	7229	536	19	1	1227	1	HJURP	2	234750399	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	679971	234750399	8448974	118	1539										
RNPEPL1	57140	broad.mit.edu	37	chr2	241517019	241517019	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagtgcccctcctgcagatgTcacgcatgtacaccatcccg	9	16	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:241517019T>C	ENST00000270357.3	+	11	1788	c.1195T>C	c.(1195-1197)Tca>Cca	p.S399P	RNPEPL1_ENST00000464550.1_3'UTR	NM_018226.4	NP_060696.4	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like 1	399					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	13		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CCTGCAGATGTCACGCATGTA	0.697													26	31					0	0	1	0	0	C	241517019	T	C	241517019	3	2	21	1	0	0	0	0	1	0	0	0	13561	1667	58	4	1229	4	RNPEPL1	2	241517019	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	6766620	241517019	1682354	119	1540										
AGXT	189	broad.mit.edu	37	chr2	241808756	241808756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggcatttgggggcagcgagCcgtggacatcggggagcgca	19	9	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:241808756C>T	ENST00000307503.3	+	2	722	c.335C>T	c.(334-336)gCc>gTc	p.A112V		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	112			A -> D (in HP1).		glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGGCAGCGAGCCGTGGACATC	0.647													41	41					0	0	1	0	0	T	241808756	C	T	241808756	3	4	21	1	0	0	0	0	1	0	0	0	401	739	26	3	341	3	AGXT	2	241808756	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	291737	241808756	1390617	120	1541										
MTERFD2	130916	broad.mit.edu	37	chr2	242036781	242036781	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agaagcctgacagtgtcgttAatgtcctgctggcgcatggt	13	9	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:242036781A>G	ENST00000391980.2	-	3	640	c.582T>C	c.(580-582)atT>atC	p.I194I	MTERFD2_ENST00000407095.3_Silent_p.I194I|MTERFD2_ENST00000495694.1_Intron|MTERFD2_ENST00000406593.1_Silent_p.I6I	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	194										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		CAGTGTCGTTAATGTCCTGCT	0.463													23	26					0	0	1	0	0	G	242036781	A	G	242036781	2	3	21	1	0	0	0	0	0	0	0	1	9967	358	13	4		4	MTERFD2	2	242036781	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	228025	242036781	1162592	121	1542										
LMCD1	29995	broad.mit.edu	37	chr3	8579029	8579029	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catccggatttacaagaggaAccggatgatcatgaccaacc	9	11	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:8579029A>G	ENST00000157600.3	+	3	522	c.290A>G	c.(289-291)aAc>aGc	p.N97S	LMCD1_ENST00000397386.3_Intron|LMCD1_ENST00000535732.1_Missense_Mutation_p.N97S|LMCD1_ENST00000454244.1_Missense_Mutation_p.N24S|LMCD1-AS1_ENST00000439407.1_RNA	NM_014583.2	NP_055398.1	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	97					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)	16				OV - Ovarian serous cystadenocarcinoma(96;0.124)		TACAAGAGGAACCGGATGATC	0.537													110	128					0	0	1	0	0	G	8579029	A	G	8579029	3	3	21	1	0	0	0	0	1	0	0	0	8884	43	2	4	300	4	LMCD1	3	8579029	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08		8579029	189443401	122	1543										
NUP210	23225	broad.mit.edu	37	chr3	13399755	13399755	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgctgcagcagcggacaggaCatgtccagctgggggctggt	17	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:13399755C>T	ENST00000254508.5	-	16	2377	c.2295G>A	c.(2293-2295)atG>atA	p.M765I		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	765					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCGGACAGGACATGTCCAGCT	0.657													30	99					0	0	1	0	0	T	13399755	C	T	13399755	3	4	21	1	0	0	0	0	1	0	0	0	10807	478	17	3	3468	3	NUP210	3	13399755	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4820726	13399755	184622675	123	1544										
CNOT10	25904	broad.mit.edu	37	chr3	32778914	32778914	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tattttagcagtaaaagccaTgatggagataaattcattcc	7	6	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:32778914T>C	ENST00000328834.5	+	13	1843	c.1527T>C	c.(1525-1527)caT>caC	p.H509H	CNOT10_ENST00000331889.6_Intron|CNOT10-AS1_ENST00000475395.2_RNA|CNOT10_ENST00000538368.1_Silent_p.H281H|CNOT10_ENST00000454516.2_Silent_p.H569H	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	509				H -> Y (in Ref. 1; BAB14108).	nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						GTAAAAGCCATGATGGAGATA	0.323													10	25					0	0	1	0	0	C	32778914	T	C	32778914	2	2	21	1	0	0	0	0	0	0	0	1	3641	1461	51	4		4	CNOT10	3	32778914	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	19379159	32778914	165243516	124	1545										
TRANK1	9881	broad.mit.edu	37	chr3	36873408	36873408	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtccgctcagcctcacccgAgaccacatagtctatttcac	6	16	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:36873408A>G	ENST00000429976.2	-	21	7781	c.7534T>C	c.(7534-7536)Tcg>Ccg	p.S2512P	TRANK1_ENST00000301807.6_Missense_Mutation_p.S1962P|TRANK1_ENST00000428977.2_Missense_Mutation_p.S1962P			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2512					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCCTCACCCGAGACCACATAG	0.527													54	74					0	0	1	0	0	G	36873408	A	G	36873408	3	3	21	1	0	0	0	0	1	0	0	0	16514	304	11	4	1255	4	TRANK1	3	36873408	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4094494	36873408	161149022	125	1546										
ITGA9	3680	broad.mit.edu	37	chr3	37544757	37544757	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggacaacacctatttaaaacTgaacgacgaagtgatcatga	8	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:37544757T>C	ENST00000264741.5	+	6	957	c.701T>C	c.(700-702)cTg>cCg	p.L234P	ITGA9_ENST00000422441.1_Missense_Mutation_p.L234P	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	234					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TATTTAAAACTGAACGACGAA	0.483													35	49					0	0	1	0	0	C	37544757	T	C	37544757	3	2	21	1	0	0	0	0	1	0	0	0	7926	1580	55	4	723	4	ITGA9	3	37544757	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	671349	37544757	160477673	126	1547										
MYD88	4615	broad.mit.edu	37	chr3	38182689	38182689	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaaagagttccccagcatccTgaggttcatcactgtctgcg	10	12	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:38182689T>C	ENST00000417037.2	+	5	1050	c.866T>C	c.(865-867)cTg>cCg	p.L289P	MYD88_ENST00000443433.2_3'UTR|MYD88_ENST00000481122.1_3'UTR|MYD88_ENST00000424893.1_Missense_Mutation_p.L236P|MYD88_ENST00000396334.3_Missense_Mutation_p.L281P|MYD88_ENST00000495303.1_3'UTR	NM_001172567.1	NP_001166038.1	Q99836	MYD88_HUMAN	myeloid differentiation primary response 88	268	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(226)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	237				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCCAGCATCCTGAGGTTCATC	0.552			Mis		ABC-DLBCL								61	80					0	0	1	0	0	C	38182689	T	C	38182689	3	2	21	1	0	0	0	0	1	0	0	0	10070	1580	55	4	884	4	MYD88	3	38182689	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	637932	38182689	159839741	127	1548										
LZTFL1	54585	broad.mit.edu	37	chr3	45879420	45879420	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tagagtcctcctctgataccTgctctccttgaggtcttgga	9	12	3	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:45879420T>C	ENST00000296135.6	-	2	301	c.128_splice	c.e2+1	p.R43_splice	LZTFL1_ENST00000536047.1_Splice_Site_p.R26_splice|LZTFL1_ENST00000539217.1_Intron|LZTFL1_ENST00000490463.1_5'UTR	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	43										endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		CTCTGATACCTGCTCTCCTTG	0.438													37	45					0	0	1	0	0	C	45879420	T	C	45879420	5	2	21	1	0	0	0	0	0	0	1	0	9181	1594	55	4	808	4	LZTFL1	3	45879420	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	7696731	45879420	152143010	128	1549										
CELSR3	1951	broad.mit.edu	37	chr3	48686273	48686273	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttggctaaaatagtggtcaGtgtggccagtcacctcccgt	11	11	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:48686273G>A	ENST00000544264.1	-	19	6951	c.6671C>T	c.(6670-6672)aCt>aTt	p.T2224I	CELSR3_ENST00000164024.4_Missense_Mutation_p.T2219I			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2219					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATAGTGGTCAGTGTGGCCAGT	0.597													39	43					0	0	1	0	0	A	48686273	G	A	48686273	3	1	21	1	0	0	0	0	1	0	0	0	3245	1029	36	3	3354	3	CELSR3	3	48686273	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2806853	48686273	149336157	129	1550										
PRKAR2A	5576	broad.mit.edu	37	chr3	48802450	48802450	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cactcacctgagtgattatgCgttctccatccttatagatc	6	12	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:48802450C>T	ENST00000265563.8	-	8	1109	c.860G>A	c.(859-861)cGc>cAc	p.R287H	PRKAR2A_ENST00000296446.8_Missense_Mutation_p.R287H|PRKAR2A_ENST00000454963.1_Missense_Mutation_p.R287H	NM_004157.2	NP_004148.1	P13861	KAP2_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, alpha	287					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		AGTGATTATGCGTTCTCCATC	0.408													12	22					0	0	1	0	0	T	48802450	C	T	48802450	3	4	21	1	0	0	0	0	1	0	0	0	12556	768	27	1	370	1	PRKAR2A	3	48802450	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	116177	48802450	149219980	130	1551										
MST1	4485	broad.mit.edu	37	chr3	49723549	49723549	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggtagcaaaaggccgcgcGcatgccgggccgcagtgtga	16	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:49723549G>A	ENST00000449682.2	-	9	1454	c.1093C>T	c.(1093-1095)Cgc>Tgc	p.R365C	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	351					proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGGCCGCGCGCATGCCGGGC	0.672													17	15					0	0	1	0	0	A	49723549	G	A	49723549	3	1	21	1	0	0	0	0	1	0	0	0	9937	1087	38	1	1124	1	MST1	3	49723549	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	921099	49723549	148298881	131	1552										
SEMA3B	7869	broad.mit.edu	37	chr3	50311871	50311871	+	RNA	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atccagtttgcgcggaaccaCcccctcatgtacaactctgt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:50311871delC	ENST00000418948.1	+	0	1449							Q13214	SEM3B_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B						axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			central_nervous_system(2)|kidney(1)|lung(2)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGCGGAACCACCCCCTCATGT	0.587											OREG0015583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	97	120	---	---	---	---						-	50311871	C	-	50311871	6	5	21	0	1	1	0	1	0	0	0	0	14078	506	18	0		0	SEMA3B	3	50311871	RNA	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	588322	50311871	147710559	132	1553										
COL8A1	1295	broad.mit.edu	37	chr3	99513775	99513775	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gactgccagggctaccaggaCccccaggccttccagggatt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:99513775delC	ENST00000261037.3	+	5	1410	c.1030delC	c.(1030-1032)ccfs	p.P345fs	COL8A1_ENST00000273342.4_Frame_Shift_Del_p.P345fs	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	345	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GCTACCAGGACCCCCAGGCCT	0.622													23	36	---	---	---	---						-	99513775	C	-	99513775	7	5	21	1	0	1	0	1	0	0	0	0	3728	507	18	0	1036	0	COL8A1	3	99513775	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	49201904	99513775	98508655	133	1554										
MORC1	27136	broad.mit.edu	37	chr3	108812302	108812302	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcctccagagctccagccaTcagtatatcttctttgtcag	6	14	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:108812302T>C	ENST00000232603.5	-	8	752	c.670A>G	c.(670-672)Atg>Gtg	p.M224V	MORC1_ENST00000483760.1_Missense_Mutation_p.M224V	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	224					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						GCTCCAGCCATCAGTATATCT	0.423													22	31					0	0	1	0	0	C	108812302	T	C	108812302	3	2	21	1	0	0	0	0	1	0	0	0	9749	1435	50	4	2368	4	MORC1	3	108812302	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	9298527	108812302	89210128	134	1555										
CCDC80	151887	broad.mit.edu	37	chr3	112357095	112357095	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgcgttctcattcttcatcTtttttttcttctccttctct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:112357095delT	ENST00000206423.3	-	2	2611	c.1658delA	c.(1657-1659)agfs	p.K553fs	CCDC80_ENST00000439685.2_Frame_Shift_Del_p.K553fs	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	553	Lys-rich.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						attcttcatcttttttttctt	0.398													12	29	---	---	---	---						-	112357095	T	-	112357095	7	5	21	1	0	1	0	1	0	0	0	0	2874	1609	56	0	1222	0	CCDC80	3	112357095	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	3544793	112357095	85665335	135	1556										
BOC	91653	broad.mit.edu	37	chr3	112998226	112998226	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagtacaagaagctaaagaaAgtgggagactggattctggc	14	5	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:112998226A>C	ENST00000495514.1	+	12	2648	c.1944A>C	c.(1942-1944)aaA>aaC	p.K648N	BOC_ENST00000273395.4_Missense_Mutation_p.K649N|BOC_ENST00000355385.3_Missense_Mutation_p.K648N			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	648	Fibronectin type-III 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			AGCTAAAGAAAGTGGGAGACT	0.612													33	54					0	0	1	0	0	C	112998226	A	C	112998226	3	2	21	1	0	0	0	0	1	0	0	0	1480	69	3	4	1982	4	BOC	3	112998226	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	641131	112998226	85024204	136	1557										
POLQ	10721	broad.mit.edu	37	chr3	121190985	121190985	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcaagcctggtaaaggatgTaatgcctttaatttatttaa	7	5	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:121190985T>C	ENST00000264233.5	-	22	6698	c.6570A>G	c.(6568-6570)ttA>ttG	p.L2190L		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2190					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		GTAAAGGATGTAATGCCTTTA	0.348								DNA polymerases (catalytic subunits)					15	27					0	0	1	0	0	C	121190985	T	C	121190985	2	2	21	1	0	0	0	0	0	0	0	1	12255	1635	57	4		4	POLQ	3	121190985	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	8192759	121190985	76831445	137	1558										
HCLS1	3059	broad.mit.edu	37	chr3	121351302	121351302	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcatagtcattctcaggctCgggctcaggctcgggctcag	12	13	5	0	rs149387044		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:121351302C>T	ENST00000314583.3	-	12	1208	c.1117G>A	c.(1117-1119)Gag>Aag	p.E373K	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.E336K	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	373					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		TTctcaggctcgggctcaggc	0.607													102	144					0	0	1	0	0	T	121351302	C	T	121351302	3	4	21	1	0	0	0	0	1	0	0	0	7035	893	31	1	355	1	HCLS1	3	121351302	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	160317	121351302	76671128	138	1559										
DTX3L	151636	broad.mit.edu	37	chr3	122289431	122289431	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accaaaagctgatttttacaGtggggtactctcgcgtatta	9	8	1	1	rs142707005		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:122289431G>A	ENST00000296161.4	+	4	2254	c.2065G>A	c.(2065-2067)Gtg>Atg	p.V689M	DTX3L_ENST00000383661.3_Missense_Mutation_p.V177M	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	689					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GATTTTTACAGTGGGGTACTC	0.433													34	57					0	0	1	0	0	A	122289431	G	A	122289431	3	1	21	1	0	0	0	0	1	0	0	0	4822	1029	36	3	2079	3	DTX3L	3	122289431	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	938129	122289431	75732999	139	1560										
MYLK	4638	broad.mit.edu	37	chr3	123348433	123348433	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtaacgttggccaaggtttCgttatcgttgtctcccatga	11	9	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:123348433C>T	ENST00000360304.3	-	30	5283	c.5002G>A	c.(5002-5004)Gaa>Aaa	p.E1668K	MYLK_ENST00000359169.1_Intron|MYLK_ENST00000360772.3_Intron|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000354792.5_Missense_Mutation_p.E468K|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000346322.5_Missense_Mutation_p.E1599K|MYLK_ENST00000475616.1_Missense_Mutation_p.E1668K|MYLK-AS1_ENST00000470449.1_RNA	NM_053025.3	NP_444253.3	Q15746	MYLK_HUMAN	myosin light chain kinase	1668	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCCAAGGTTTCGTTATCGTTG	0.557													38	35					0	0	1	0	0	T	123348433	C	T	123348433	3	4	21	1	0	0	0	0	1	0	0	0	10103	893	31	1	762	1	MYLK	3	123348433	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1059002	123348433	74673997	140	1561										
MYLK	4638	broad.mit.edu	37	chr3	123419539	123419539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgccgctgcaggttggcacGgaaatccatctgctcggctg	13	12	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:123419539G>A	ENST00000360772.3	-	19	3154	c.2776C>T	c.(2776-2778)Cgt>Tgt	p.R926C	MYLK_ENST00000359169.1_Missense_Mutation_p.R926C|MYLK_ENST00000360304.3_Missense_Mutation_p.R926C|MYLK_ENST00000346322.5_Missense_Mutation_p.R857C|MYLK_ENST00000475616.1_Missense_Mutation_p.R926C			Q15746	MYLK_HUMAN	myosin light chain kinase	926	5 X 28 AA approximate tandem repeats.|Actin-binding (calcium/calmodulin- sensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGGTTGGCACGGAAATCCATC	0.572													37	54					0	0	1	0	0	A	123419539	G	A	123419539	3	1	21	1	0	0	0	0	1	0	0	0	10103	1116	39	1	3036	1	MYLK	3	123419539	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	71106	123419539	74602891	141	1562										
MCM2	4171	broad.mit.edu	37	chr3	127323896	127323896	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagtgggtgagcatggcgggCccccggctggagatccacca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:127323896delC	ENST00000265056.7	+	4	814	c.570delC	c.(568-570)ggfs	p.G190fs		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	190	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GCATGGCGGGCCCCCGGCTGG	0.622													38	97	---	---	---	---						-	127323896	C	-	127323896	7	5	21	1	0	1	0	1	0	0	0	0	9435	726	26	0	584	0	MCM2	3	127323896	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3904357	127323896	70698534	142	1563										
MCM2	4171	broad.mit.edu	37	chr3	127335929	127335929	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggccctggttctggctgacCgaggagtgtgtctcattgat	15	9	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:127335929C>T	ENST00000265056.7	+	10	1985	c.1741C>T	c.(1741-1743)Cga>Tga	p.R581*		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	581	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						TCTGGCTGACCGAGGAGTGTG	0.647													82	98					0	0	1	0	0	T	127335929	C	T	127335929	4	4	21	1	0	0	0	0	0	1	0	0	9435	644	23	1	1779	1	MCM2	3	127335929	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	12033	127335929	70686501	143	1564										
DNAJB8	165721	broad.mit.edu	37	chr3	128181453	128181453	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtcaccgacttgagctgcccGtcttcctccacctccacgcg	8	19	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:128181453G>A	ENST00000469083.1	-	2	3193	c.636C>T	c.(634-636)gaC>gaT	p.D212D	DNAJB8_ENST00000319153.3_Silent_p.D212D			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	212					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		TGAGCTGCCCGTCTTCCTCCA	0.612													90	100					0	0	1	0	0	A	128181453	G	A	128181453	2	1	21	1	0	0	0	0	0	0	0	1	4653	1136	40	1		1	DNAJB8	3	128181453	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	845524	128181453	69840977	144	1565										
IFT122	55764	broad.mit.edu	37	chr3	129207227	129207227	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctagaaggtttagattttgAaacagcaaagaaggtaagca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:129207227delA	ENST00000296266.3	+	17	2324	c.2132delA	c.(2131-2133)gafs	p.E711fs	IFT122_ENST00000431818.2_Frame_Shift_Del_p.E510fs|IFT122_ENST00000440957.2_Frame_Shift_Del_p.E451fs|IFT122_ENST00000349441.2_Frame_Shift_Del_p.E549fs|IFT122_ENST00000348417.2_Frame_Shift_Del_p.E660fs|IFT122_ENST00000347300.2_Frame_Shift_Del_p.E601fs|IFT122_ENST00000504021.1_Frame_Shift_Del_p.E554fs|IFT122_ENST00000507564.1_Frame_Shift_Del_p.E652fs	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	660					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTAGATTTTGAAACAGCAAAG	0.522													29	48	---	---	---	---						-	129207227	A	-	129207227	7	5	21	1	0	1	0	1	0	0	0	0	7598	246	9	0	2198	0	IFT122	3	129207227	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1025774	129207227	68815203	145	1566										
ASTE1	28990	broad.mit.edu	37	chr3	130743461	130743461	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttaagaatgtctccatgatGggtagattaacatggtcatt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:130743461delG	ENST00000264992.3	-	3	1131	c.690delC	c.(688-690)ccfs	p.P230fs	ASTE1_ENST00000514044.1_Frame_Shift_Del_p.P230fs	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	230					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						TCTCCATGATGGGTAGATTAA	0.448													28	92	---	---	---	---						-	130743461	G	-	130743461	7	5	21	1	0	1	0	1	0	0	0	0	1061	1335	47	0	1365	0	ASTE1	3	130743461	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1536234	130743461	67278969	146	1567										
GRK7	131890	broad.mit.edu	37	chr3	141499234	141499234	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggtatgtgccgtccaggtgAaaaacactgggaagatgtat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:141499234delA	ENST00000264952.2	+	2	768	c.631delA	c.(631-633)aafs	p.K211fs		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	211	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CGTCCAGGTGAAAAACACTGG	0.458													17	25	---	---	---	---						-	141499234	A	-	141499234	7	5	21	1	0	1	0	1	0	0	0	0	6834	247	9	0	637	0	GRK7	3	141499234	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	10755773	141499234	56523196	147	1568										
ZIC4	84107	broad.mit.edu	37	chr3	147113791	147113791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgaagggctttccctggcgcGgacactcctcccagaagcaa	11	14	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:147113791G>A	ENST00000383075.3	-	3	1048	c.536C>T	c.(535-537)cCg>cTg	p.P179L	ZIC4_ENST00000473123.1_Missense_Mutation_p.P179L|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000525172.2_Missense_Mutation_p.P229L|ZIC4_ENST00000425731.3_Missense_Mutation_p.P217L|ZIC4_ENST00000484399.1_Missense_Mutation_p.P179L	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	179						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TCCCTGGCGCGGACACTCCTC	0.587													25	190					0	0	1	0	0	A	147113791	G	A	147113791	3	1	21	1	0	0	0	0	1	0	0	0	17738	1116	39	1	480	1	ZIC4	3	147113791	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5614557	147113791	50908639	148	1569										
PFN2	5217	broad.mit.edu	37	chr3	149684300	149684300	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacccagagtctctcaagtaTtttgccattgagtatgcctt	7	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:149684300T>C	ENST00000239940.7	-	3	651	c.399A>G	c.(397-399)aaA>aaG	p.K133K	PFN2_ENST00000481767.1_Intron|PFN2_ENST00000489155.1_Silent_p.K84K|PFN2_ENST00000490975.1_Silent_p.K118K|PFN2_ENST00000497148.1_Silent_p.K84K|PFN2_ENST00000452853.2_Intron|PFN2_ENST00000423691.2_Intron|PFN2_ENST00000475518.1_Silent_p.K84K|PFN2_ENST00000481275.1_Silent_p.K84K|PFN2_ENST00000494827.1_Intron|PFN2_ENST00000498307.1_Silent_p.K84K			P35080	PROF2_HUMAN	profilin 2	133					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CTCTCAAGTATTTTGCCATTG	0.393													269	327					0	0	1	0	0	C	149684300	T	C	149684300	2	2	21	1	0	0	0	0	0	0	0	1	11815	1490	52	4		4	PFN2	3	149684300	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2570509	149684300	48338130	149	1570										
P2RY12	0	broad.mit.edu	37	chr3	151056503	151056503	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agaaaatcctcatcgccaggCcatttgtgataagtccaaca	7	11	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:151056503C>T	ENST00000302632.3	-	3	430	c.131G>A	c.(130-132)gGc>gAc	p.G44D	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	44					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	CATCGCCAGGCCATTTGTGAT	0.403													19	36					0	0	1	0	0	T	151056503	C	T	151056503	3	4	21	1	0	0	0	0	1	0	0	0	11395	739	26	3	901	3	P2RY12	3	151056503	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1372203	151056503	46965927	150	1571										
PLCH1	23007	broad.mit.edu	37	chr3	155206447	155206447	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaaaaggccagctcatacctAccaggcactaagctgctgaa	9	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:155206447A>G	ENST00000460012.1	-	20	2807		c.e20+1		PLCH1_ENST00000334686.6_Splice_Site|PLCH1_ENST00000414191.1_Splice_Site|PLCH1_ENST00000447496.2_Splice_Site|PLCH1_ENST00000340059.7_Splice_Site|PLCH1_ENST00000494598.1_Splice_Site			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1						lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCTCATACCTACCAGGCACTA	0.408													24	28					0	0	1	0	0	G	155206447	A	G	155206447	5	3	21	1	0	0	0	0	0	0	1	0	12084	405	14	4	2611	4	PLCH1	3	155206447	Splice_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4149944	155206447	42815983	151	1572										
SI	6476	broad.mit.edu	37	chr3	164712126	164712126	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaaaatagggcaataaggtgTatctaatatttagaatattc	7	3	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:164712126T>C	ENST00000264382.3	-	41	4822	c.4760A>G	c.(4759-4761)tAc>tGc	p.Y1587C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1587	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAATAAGGTGTATCTAATATT	0.348										HNSCC(35;0.089)			30	27					0	0	1	0	0	C	164712126	T	C	164712126	3	2	21	1	0	0	0	0	1	0	0	0	14351	1638	57	4	755	4	SI	3	164712126	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	9505679	164712126	33310304	152	1573										
GOLIM4	27333	broad.mit.edu	37	chr3	167754717	167754717	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttttgctgttctgctggatcAggttttcgaaggcttggaat	12	6	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:167754717A>G	ENST00000470487.1	-	8	1439	c.750T>C	c.(748-750)ccT>ccC	p.P250P	GOLIM4_ENST00000309027.4_Silent_p.P222P	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	250					transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTGCTGGATCAGGTTTTCGAA	0.453													53	93					0	0	1	0	0	G	167754717	A	G	167754717	2	3	21	1	0	0	0	0	0	0	0	1	6604	175	7	4		4	GOLIM4	3	167754717	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3042591	167754717	30267713	153	1574										
PHC3	80012	broad.mit.edu	37	chr3	169846643	169846643	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccctgggacagaatttcaggCtgcacttgtaaagactgcat	10	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:169846643C>T	ENST00000494943.1	-	8	1649	c.1581G>A	c.(1579-1581)caG>caA	p.Q527Q	PHC3_ENST00000467570.1_Silent_p.Q486Q|PHC3_ENST00000495893.1_Silent_p.Q539Q			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	527	Gln-rich.|Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAATTTCAGGCTGCACTTGTA	0.507													69	74					0	0	1	0	0	T	169846643	C	T	169846643	2	4	21	1	0	0	0	0	0	0	0	1	11865	796	28	3		3	PHC3	3	169846643	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2091926	169846643	28175787	154	1575										
MFN1	55669	broad.mit.edu	37	chr3	179107816	179107816	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atagctaccacttttgctcgCctgtgccaacaagttgatat	7	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:179107816C>T	ENST00000471841.1	+	17	2163	c.2037C>T	c.(2035-2037)cgC>cgT	p.R679R	MFN1_ENST00000263969.5_Silent_p.R679R|MFN1_ENST00000280653.7_Silent_p.R568R	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	679					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CTTTTGCTCGCCTGTGCCAAC	0.299													10	17					0	0	1	0	0	T	179107816	C	T	179107816	2	4	21	1	0	0	0	0	0	0	0	1	9572	726	26	3		3	MFN1	3	179107816	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	9261173	179107816	18914614	155	1576										
YEATS2	55689	broad.mit.edu	37	chr3	183515755	183515755	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtccagtccgcagcaggccGtcctgacgattcccagccag	11	16	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:183515755G>A	ENST00000305135.5	+	22	3337	c.3142G>A	c.(3142-3144)Gtc>Atc	p.V1048I		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1048					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCAGCAGGCCGTCCTGACGAT	0.512													29	35					0	0	1	0	0	A	183515755	G	A	183515755	3	1	21	1	0	0	0	0	1	0	0	0	17531	1145	40	1	3224	1	YEATS2	3	183515755	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4407939	183515755	14506675	156	1577										
DVL3	1857	broad.mit.edu	37	chr3	183888361	183888361	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acccgagctacggtcctcccGgagtgccccctctctacggc	10	19	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:183888361G>A	ENST00000313143.3	+	15	2217	c.1969G>A	c.(1969-1971)Gga>Aga	p.G657R	DVL3_ENST00000431765.1_Missense_Mutation_p.G640R|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	657					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CGGTCCTCCCGGAGTGCCCCC	0.746													19	13					0	0	1	0	0	A	183888361	G	A	183888361	3	1	21	1	0	0	0	0	1	0	0	0	4863	1117	39	1	2027	1	DVL3	3	183888361	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	372606	183888361	14134069	157	1578										
ECE2	9718	broad.mit.edu	37	chr3	183994375	183994375	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtgggcaagggggcttcccCtttctcaccaggccccagcc	13	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:183994375C>T	ENST00000357474.5	+	2	265	c.146C>T	c.(145-147)cCt>cTt	p.P49L	ECE2_ENST00000359140.4_Intron|ECE2_ENST00000404464.3_Intron|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000402825.3_Intron			O60344	ECE2_HUMAN	endothelin converting enzyme 2	0	Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGGCTTCCCCTTTCTCACCA	0.687													7	17					0	0	1	0	0	T	183994375	C	T	183994375	3	4	21	1	0	0	0	0	1	0	0	0	4916	681	24	3	932	3	ECE2	3	183994375	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	106014	183994375	14028055	158	1579										
MASP1	5648	broad.mit.edu	37	chr3	186953726	186953726	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccagcacagaacatgttctCcgtgacgctgtaattgcccg	10	13	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:186953726C>T	ENST00000296280.6	-	11	2158	c.1933G>A	c.(1933-1935)Gag>Aag	p.E645K	MASP1_ENST00000337774.5_Intron|MASP1_ENST00000495249.1_5'UTR|MASP1_ENST00000392472.2_Missense_Mutation_p.E532K	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	627	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AACATGTTCTCCGTGACGCTG	0.547													23	34					0	0	1	0	0	T	186953726	C	T	186953726	3	4	21	1	0	0	0	0	1	0	0	0	9371	864	30	3	1078	3	MASP1	3	186953726	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2959351	186953726	11068704	159	1580										
FGF12	2257	broad.mit.edu	37	chr3	192053197	192053197	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catggccacatagaggctagCcttcactccttggatggcca	10	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:192053197C>T	ENST00000454309.2	-	3	1192	c.367G>A	c.(367-369)Gct>Act	p.A123T	FGF12_ENST00000264730.3_Missense_Mutation_p.A61T|FGF12_ENST00000445105.1_Missense_Mutation_p.A61T|FGF12_ENST00000450716.1_Missense_Mutation_p.A61T|FGF12_ENST00000430714.1_Missense_Mutation_p.A24T	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	123					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TAGAGGCTAGCCTTCACTCCT	0.478													15	36					0	0	1	0	0	T	192053197	C	T	192053197	3	4	21	1	0	0	0	0	1	0	0	0	5873	739	26	3	376	3	FGF12	3	192053197	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5099471	192053197	5969233	160	1581										
FBXO45	200933	broad.mit.edu	37	chr3	196304421	196304421	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acatcgaaaccccattgctcAgagcactgatggtgcaagga	10	11	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:196304421A>G	ENST00000311630.6	+	2	713	c.416A>G	c.(415-417)cAg>cGg	p.Q139R	FBXO45_ENST00000440469.1_5'UTR	NM_001105573.1	NP_001099043.1	P0C2W1	FBSP1_HUMAN	F-box protein 45	139	B30.2/SPRY.				nervous system development|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	cell junction|postsynaptic membrane|presynaptic membrane	protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	7	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;2.75e-23)|all cancers(36;2.47e-21)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		CCCATTGCTCAGAGCACTGAT	0.498													13	20					0	0	1	0	0	G	196304421	A	G	196304421	3	3	21	1	0	0	0	0	1	0	0	0	5786	188	7	4	422	4	FBXO45	3	196304421	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4251224	196304421	1718009	161	1582										
MFI2	4241	broad.mit.edu	37	chr3	196730857	196730857	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgcggtaggtggttttctcTccgacaggcaccgcccggac	13	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:196730857T>C	ENST00000296350.5	-	15	2165	c.2052A>G	c.(2050-2052)ggA>ggG	p.G684G	MFI2-AS1_ENST00000437064.1_RNA|MFI2-AS1_ENST00000415244.1_RNA|MFI2-AS1_ENST00000424769.1_RNA|MFI2-AS1_ENST00000414354.1_RNA	NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	684	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		TGGTTTTCTCTCCGACAGGCA	0.607													184	242					0	0	1	0	0	C	196730857	T	C	196730857	2	2	21	1	0	0	0	0	0	0	0	1	9571	1538	54	4		4	MFI2	3	196730857	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	426436	196730857	1291573	162	1583										
MFI2	4241	broad.mit.edu	37	chr3	196733483	196733483	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcgggccggaccatcacggcGtggggtggtatctgtgccag	17	11	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:196733483G>A	ENST00000296350.5	-	14	1988	c.1875C>T	c.(1873-1875)caC>caT	p.H625H		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	625	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CCATCACGGCGTGGGGTGGTA	0.627													17	39					0	0	1	0	0	A	196733483	G	A	196733483	2	1	21	1	0	0	0	0	0	0	0	1	9571	1136	40	1		1	MFI2	3	196733483	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2626	196733483	1288947	163	1584										
FGFRL1	53834	broad.mit.edu	37	chr4	1017702	1017702	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagtgcgtggccagcgggcaCcctcggcccgacatcacgtg	14	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:1017702C>T	ENST00000398484.2	+	6	1111	c.531C>T	c.(529-531)caC>caT	p.H177H	FGFRL1_ENST00000264748.6_Silent_p.H177H|FGFRL1_ENST00000510644.1_Silent_p.H177H|FGFRL1_ENST00000504138.1_Silent_p.H177H			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	177	Ig-like C2-type 2.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCAGCGGGCACCCTCGGCCCG	0.667													6	8					0	0	1	0	0	T	1017702	C	T	1017702	2	4	21	1	0	0	0	0	0	0	0	1	5901	506	18	3		3	FGFRL1	4	1017702	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08		1017702	190136574	164	1585										
TACC3	10460	broad.mit.edu	37	chr4	1729657	1729657	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctccaggaaaagtgtctggCagccctgagcaagccgtgga	13	11	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:1729657C>T	ENST00000313288.4	+	4	634	c.528C>T	c.(526-528)ggC>ggT	p.G176G		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	176						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AAGTGTCTGGCAGCCCTGAGC	0.552													58	73					0	0	1	0	0	T	1729657	C	T	1729657	2	4	21	1	0	0	0	0	0	0	0	1	15559	697	25	3		3	TACC3	4	1729657	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	711955	1729657	189424619	165	1586										
HAUS3	79441	broad.mit.edu	37	chr4	2242253	2242253	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctttttagtggcttcttcttCtttagcatttaacctcagag	6	9	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:2242253C>T	ENST00000243706.4	-	2	650	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	HAUS3_ENST00000506763.1_Missense_Mutation_p.E141K|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000443786.2_Missense_Mutation_p.E141K|POLN_ENST00000515357.1_Intron	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	141					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GCTTCTTCTTCTTTAGCATTT	0.353													26	40					0	0	1	0	0	T	2242253	C	T	2242253	3	4	21	1	0	0	0	0	1	0	0	0	7007	922	32	3	1406	3	HAUS3	4	2242253	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	512596	2242253	188912023	166	1587										
JAKMIP1	152789	broad.mit.edu	37	chr4	6031488	6031488	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgcttctgaaactccagtttGtcctccagttctcggattct	7	13	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:6031488G>A	ENST00000409021.3	-	20	2849	c.2400C>T	c.(2398-2400)gaC>gaT	p.D800D	JAKMIP1_ENST00000409371.3_Silent_p.D615D	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	571					protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACTCCAGTTTGTCCTCCAGTT	0.418													5	9					0	0	1	0	0	A	6031488	G	A	6031488	2	1	21	1	0	0	0	0	0	0	0	1	7983	1368	48	3		3	JAKMIP1	4	6031488	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3789235	6031488	185122788	167	1588										
WFS1	7466	broad.mit.edu	37	chr4	6302765	6302765	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctgctctctgtcttcttcGtcatcttctccttccccatc	3	18	6	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:6302765G>A	ENST00000226760.1	+	8	1413	c.1243G>A	c.(1243-1245)Gtc>Atc	p.V415I	WFS1_ENST00000503569.1_Missense_Mutation_p.V415I	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	415			Missing (in WFS).		endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		TGTCTTCTTCGTCATCTTCTC	0.597													78	114					0	0	1	0	0	A	6302765	G	A	6302765	3	1	21	1	0	0	0	0	1	0	0	0	17419	1145	40	1	1269	1	WFS1	4	6302765	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	271277	6302765	184851511	168	1589										
GPR78	27201	broad.mit.edu	37	chr4	8588799	8588799	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggctggcggagctcgtgccCttcgtcaccgtgaacgccca	13	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:8588799C>A	ENST00000382487.4	+	3	1218	c.801C>A	c.(799-801)ccC>ccA	p.P267P	GPR78_ENST00000509216.1_3'UTR	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	267					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						AGCTCGTGCCCTTCGTCACCG	0.652													24	36					5.45024e-15	5.86486e-15	1	1	0	A	8588799	C	A	8588799	2	1	21	1	0	0	0	0	0	0	0	1	6749	668	24	5		5	GPR78	4	8588799	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2286034	8588799	182565477	169	1590										
DRD5	0	broad.mit.edu	37	chr4	9784646	9784646	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caccccgaaggccctccggcCggcttcccctgcgtcagtga	11	19	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:9784646C>T	ENST00000304374.2	+	1	1389	c.993C>T	c.(991-993)gcC>gcT	p.A331A		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	331					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GCCCTCCGGCCGGCTTCCCCT	0.592													84	84					0	0	1	0	0	T	9784646	C	T	9784646	2	4	21	1	0	0	0	0	0	0	0	1	4786	639	23	1		1	DRD5	4	9784646	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1195847	9784646	181369630	170	1591										
ZNF518B	85460	broad.mit.edu	37	chr4	10447381	10447381	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catagtcacaatactcacacTgataaggaaatatgcctgtg	7	9	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:10447381T>C	ENST00000326756.3	-	3	1010	c.572A>G	c.(571-573)cAg>cGg	p.Q191R		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ATACTCACACTGATAAGGAAA	0.403													71	73					0	0	1	0	0	C	10447381	T	C	10447381	3	2	21	1	0	0	0	0	1	0	0	0	18019	1580	55	4	2656	4	ZNF518B	4	10447381	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	662735	10447381	180706895	171	1592										
SLC34A2	10568	broad.mit.edu	37	chr4	25675930	25675930	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcttccagatttcccctttcCctttgcatggttgactggct	7	13	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:25675930C>A	ENST00000382051.3	+	11	1279	c.1229C>A	c.(1228-1230)cCc>cAc	p.P410H	SLC34A2_ENST00000504570.1_Missense_Mutation_p.P409H|SLC34A2_ENST00000503434.1_Missense_Mutation_p.P409H	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	410					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TTCCCCTTTCCCTTTGCATGG	0.602			T	ROS1	NSCLC								22	45					7.41877e-09	7.82003e-09	1	1	0	A	25675930	C	A	25675930	3	1	21	1	0	0	0	0	1	0	0	0	14622	623	22	5	1267	5	SLC34A2	4	25675930	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	15228549	25675930	165478346	172	1593										
UGT2B28	54490	broad.mit.edu	37	chr4	70156526	70156526	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaagacagtaattaatgatcCttcgtgagtagaacagtatt	9	5	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:70156526C>A	ENST00000335568.5	+	5	1309	c.1307C>A	c.(1306-1308)cCt>cAt	p.P436H	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	436					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	ATTAATGATCCTTCGTGAGTA	0.398													48	68					4.86159e-25	5.41756e-25	1	1	0	A	70156526	C	A	70156526	3	1	21	1	0	0	0	0	1	0	0	0	17019	681	24	5	1325	5	UGT2B28	4	70156526	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	44480596	70156526	120997750	173	1594										
AFP	174	broad.mit.edu	37	chr4	74315095	74315095	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gacatcctcagcttgctgtcTcagtaattctaagagttgct	8	10	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:74315095T>C	ENST00000395792.2	+	9	1202	c.1102T>C	c.(1102-1104)Tca>Cca	p.S368P	AFP_ENST00000226359.2_Missense_Mutation_p.S368P	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	368	Albumin 2.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCTTGCTGTCTCAGTAATTCT	0.373									Alpha-Fetoprotein, Hereditary Persistence of				28	41					0	0	1	0	0	C	74315095	T	C	74315095	3	2	21	1	0	0	0	0	1	0	0	0	362	1551	54	4	1136	4	AFP	4	74315095	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4158569	74315095	116839181	174	1595										
SCARB2	950	broad.mit.edu	37	chr4	77091020	77091020	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggaggaagtatgtactcacAggattaatgtccacaaatgt	10	6	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:77091020A>C	ENST00000264896.2	-	8	1462	c.1113_splice	c.e8+1	p.P371_splice	SCARB2_ENST00000452464.2_Splice_Site_p.P228_splice	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	371					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			ATGTACTCACAGGATTAATGT	0.393													38	61					0	0	1	0	0	C	77091020	A	C	77091020	5	2	21	1	0	0	0	0	0	0	1	0	13934	202	7	4	343	4	SCARB2	4	77091020	Splice_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2775925	77091020	114063256	175	1596										
SEC31A	22872	broad.mit.edu	37	chr4	83788042	83788042	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atactatgctgagcagtctgCtgtggaatttgtaacggagg	13	6	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:83788042C>T	ENST00000432794.1	-	10	1279	c.1116G>A	c.(1114-1116)caG>caA	p.Q372Q	SEC31A_ENST00000436790.2_5'UTR|SEC31A_ENST00000508479.1_Silent_p.Q372Q|SEC31A_ENST00000311785.7_Silent_p.Q372Q|SEC31A_ENST00000513858.1_Silent_p.Q372Q|SEC31A_ENST00000505472.1_Silent_p.Q372Q|SEC31A_ENST00000509142.1_Silent_p.Q372Q|SEC31A_ENST00000508502.1_Silent_p.Q372Q|SEC31A_ENST00000505984.1_Silent_p.Q372Q|SEC31A_ENST00000264405.5_Silent_p.Q144Q|SEC31A_ENST00000448323.1_Silent_p.Q372Q|SEC31A_ENST00000443462.2_Silent_p.Q367Q|SEC31A_ENST00000395310.2_Silent_p.Q372Q|SEC31A_ENST00000355196.2_Silent_p.Q372Q|SEC31A_ENST00000348405.4_Silent_p.Q372Q|SEC31A_ENST00000500777.2_Silent_p.Q372Q|SEC31A_ENST00000326950.5_Silent_p.Q372Q			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	372	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				GAGCAGTCTGCTGTGGAATTT	0.433													70	95					0	0	1	0	0	T	83788042	C	T	83788042	2	4	21	1	0	0	0	0	0	0	0	1	14051	796	28	3		3	SEC31A	4	83788042	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6697022	83788042	107366234	176	1597										
AGPAT9	84803	broad.mit.edu	37	chr4	84502845	84502845	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	attgtagaagatgaagtgacCcagaggttttcctcagagga	12	6	1	6			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:84502845C>T	ENST00000395226.2	+	4	557	c.339C>T	c.(337-339)acC>acT	p.T113T	AGPAT9_ENST00000264409.4_Silent_p.T113T	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	113					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				ATGAAGTGACCCAGAGGTTTT	0.468													59	102					0	0	1	0	0	T	84502845	C	T	84502845	2	4	21	1	0	0	0	0	0	0	0	1	389	610	22	3		3	AGPAT9	4	84502845	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	714803	84502845	106651431	177	1598										
MMRN1	22915	broad.mit.edu	37	chr4	90816607	90816607	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctaaacacagttggaggcaCtggaggcattggaggcgttg	15	7	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:90816607C>G	ENST00000394980.1	+	2	804	c.485C>G	c.(484-486)aCt>aGt	p.T162S	MMRN1_ENST00000394981.1_Missense_Mutation_p.T128S|MMRN1_ENST00000264790.2_Missense_Mutation_p.T162S			Q13201	MMRN1_HUMAN	multimerin 1	162					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GTtggaggcactggaggcatt	0.507													35	39					0	0	1	0	0	G	90816607	C	G	90816607	3	3	21	1	0	0	0	0	1	0	0	0	9718	565	20	5	487	5	MMRN1	4	90816607	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6313762	90816607	100337669	178	1599										
ADH4	127	broad.mit.edu	37	chr4	100045604	100045604	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggcatcttcaaaagatgaGgattgttcggacgctgttaa	11	7	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:100045604G>T	ENST00000508393.1	-	10	1354	c.1189C>A	c.(1189-1191)Ctc>Atc	p.L397I	RP11-696N14.1_ENST00000500358.2_RNA|ADH4_ENST00000265512.7_Missense_Mutation_p.L378I|ADH4_ENST00000505590.1_Missense_Mutation_p.L397I|ADH4_ENST00000423445.1_Missense_Mutation_p.L397I			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	378					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	CAAAAGATGAGGATTGTTCGG	0.323													3	8					0.00909568	0.00916886	1	1	0	T	100045604	G	T	100045604	3	4	21	1	0	0	0	0	1	0	0	0	309	1000	35	5	14	5	ADH4	4	100045604	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9228997	100045604	91108672	179	1600										
INTS12	57117	broad.mit.edu	37	chr4	106604358	106604360	+	In_Frame_Del	DEL	TGT	TGT	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttgttgaactcaattttgcTgttgaaggaccagcagagga							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:106604358_106604360delTGT	ENST00000451321.2	-	7	1398_1400	c.919_921delACA	c.(919-921)del	p.T307del	INTS12_ENST00000394735.1_In_Frame_Del_p.T307del|INTS12_ENST00000340139.5_In_Frame_Del_p.T307del	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	307	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TCAATTTTGCTGTTGAAGGACCA	0.458													42	67	---	---	---	---						-	106604360	TGT	-	106604358	7	5	21	1	0	1	0	1	0	0	0	0	7820	1567	55	0	471	0	INTS12	4	106604358	In_Frame_Del	DEL	TGT	TCGA-N7-A4Y0-01A-12D-A28R-08	6558754	106604358	84549918	180	1601										
SEC24B	10427	broad.mit.edu	37	chr4	110384778	110384778	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acaggatccctggctgtagcGaacaacaacccaaccattac	7	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:110384778G>A	ENST00000265175.5	+	2	910	c.855G>A	c.(853-855)gcG>gcA	p.A285A	SEC24B_ENST00000399100.2_Silent_p.A285A|SEC24B_ENST00000504968.2_Silent_p.A316A	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	285					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGGCTGTAGCGAACAACAACC	0.413													30	57					0	0	1	0	0	A	110384778	G	A	110384778	2	1	21	1	0	0	0	0	0	0	0	1	14048	1045	37	1		1	SEC24B	4	110384778	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3780420	110384778	80769498	181	1602										
PCDH10	57575	broad.mit.edu	37	chr4	134073201	134073201	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcgcatggactggcgcaccGgggagctgcgcacagcacgc	15	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:134073201G>A	ENST00000264360.4	+	1	2732	c.1906G>A	c.(1906-1908)Ggg>Agg	p.G636R		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	636	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CTGGCGCACCGGGGAGCTGCG	0.682													43	67					0	0	1	0	0	A	134073201	G	A	134073201	3	1	21	1	0	0	0	0	1	0	0	0	11553	1116	39	1	1908	1	PCDH10	4	134073201	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	23688423	134073201	57081075	182	1603										
CLGN	1047	broad.mit.edu	37	chr4	141334145	141334145	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttctgaattttcttcaaagtCttccgtctcaacatcatcat	3	11	7	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:141334145C>A	ENST00000325617.5	-	2	528	c.88G>T	c.(88-90)Gac>Tac	p.D30Y	CLGN_ENST00000414773.1_Missense_Mutation_p.D30Y|CLGN_ENST00000537281.1_Missense_Mutation_p.D30Y	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	30					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding	p.D30N(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TCTTCAAAGTCTTCCGTCTCA	0.328													11	31					1.58986e-06	1.64812e-06	1	1	0	A	141334145	C	A	141334145	3	1	21	1	0	0	0	0	1	0	0	0	3547	913	32	2	1800	2	CLGN	4	141334145	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7260944	141334145	49820131	183	1604										
RNF150	57484	broad.mit.edu	37	chr4	142053668	142053668	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttggggtcgcaggccaggcGgtcgtgggccgagctggcca	20	11	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:142053668G>T	ENST00000306799.3	-	1	948	c.295C>A	c.(295-297)Cgc>Agc	p.R99S	RNF150_ENST00000515673.1_Missense_Mutation_p.R99S|RNF150_ENST00000420921.2_Intron|RNF150_ENST00000507500.1_Missense_Mutation_p.R99S	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	99	PA.					integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					CAGGCCAGGCGGTCGTGGGCC	0.672													3	5					1	1	1	1	0	T	142053668	G	T	142053668	3	4	21	1	0	0	0	0	1	0	0	0	13502	1116	39	5	1049	5	RNF150	4	142053668	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	719523	142053668	49100608	184	1605										
ARHGAP10	79658	broad.mit.edu	37	chr4	148984433	148984433	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttctcctcctgctactgtagCggacaagccacctgaaaggt	9	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:148984433C>T	ENST00000336498.3	+	21	2401	c.2162C>T	c.(2161-2163)gCg>gTg	p.A721V	ARHGAP10_ENST00000414545.2_Intron	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	721					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GCTACTGTAGCGGACAAGCCA	0.532													18	29					0	0	1	0	0	T	148984433	C	T	148984433	3	4	21	1	0	0	0	0	1	0	0	0	859	768	27	1	2244	1	ARHGAP10	4	148984433	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6930765	148984433	42169843	185	1606										
LRBA	987	broad.mit.edu	37	chr4	151749479	151749479	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaatgtctttcacattgacgTtttttgaaactgaaactgac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:151749479delT	ENST00000535741.1	-	30	5497	c.5024delA	c.(5023-5025)acfs	p.N1675fs	LRBA_ENST00000507224.1_Frame_Shift_Del_p.N1675fs|LRBA_ENST00000510413.1_Frame_Shift_Del_p.N1675fs|LRBA_ENST00000357115.3_Frame_Shift_Del_p.N1675fs			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1675						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CACATTGACGTTTTTTGAAAC	0.448													30	67	---	---	---	---						-	151749479	T	-	151749479	7	5	21	1	0	1	0	1	0	0	0	0	8975	1725	60	0	3683	0	LRBA	4	151749479	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2765046	151749479	39404797	186	1607										
FHDC1	85462	broad.mit.edu	37	chr4	153864220	153864220	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caacagtactatgcatgttaTgaattgtgtctccttggtca	8	8	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:153864220T>G	ENST00000511601.1	+	2	199	c.11T>G	c.(10-12)aTg>aGg	p.M4R	FHDC1_ENST00000260008.3_Missense_Mutation_p.M4R			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	4					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ATGCATGTTATGAATTGTGTC	0.448													37	32					0	0	1	0	0	G	153864220	T	G	153864220	3	3	21	1	0	0	0	0	1	0	0	0	5908	1464	51	4	13	4	FHDC1	4	153864220	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2114741	153864220	37290056	187	1608										
FBXO8	26269	broad.mit.edu	37	chr4	175160263	175160263	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcaggggcatggatatgacgAaaaaattctctcagtgcatt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:175160263delA	ENST00000393674.2	-	5	1516	c.654delT	c.(652-654)ttfs	p.F218fs	FBXO8_ENST00000503293.1_Frame_Shift_Del_p.F177fs	NM_012180.2	NP_036312.2	Q9NRD0	FBX8_HUMAN	F-box protein 8	218	SEC7.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|urinary_tract(1)	14		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		GGATATGACGAAAAAATTCTC	0.388													24	35	---	---	---	---						-	175160263	A	-	175160263	7	5	21	1	0	1	0	1	0	0	0	0	5793	243	9	0	313	0	FBXO8	4	175160263	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	21296043	175160263	15994013	188	1609										
SORBS2	8470	broad.mit.edu	37	chr4	186567832	186567832	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagtgcttactggtctttcaTgctgaagaattgatgacttg	10	6	2	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:186567832T>C	ENST00000431808.1	-	11	1237	c.674A>G	c.(673-675)cAt>cGt	p.H225R	SORBS2_ENST00000449407.2_Missense_Mutation_p.H296R|SORBS2_ENST00000448662.2_Missense_Mutation_p.H294R|SORBS2_ENST00000437304.2_Missense_Mutation_p.H404R|SORBS2_ENST00000418609.1_Missense_Mutation_p.H129R|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000393528.3_Missense_Mutation_p.H271R|SORBS2_ENST00000355634.5_Missense_Mutation_p.H325R|SORBS2_ENST00000319471.9_Missense_Mutation_p.H311R|SORBS2_ENST00000284776.7_Missense_Mutation_p.H225R			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	225						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TGGTCTTTCATGCTGAAGAAT	0.438													29	33					0	0	1	0	0	C	186567832	T	C	186567832	3	2	21	1	0	0	0	0	1	0	0	0	14981	1464	51	4	2988	4	SORBS2	4	186567832	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	11407569	186567832	4586444	189	1610										
KLKB1	3818	broad.mit.edu	37	chr4	187159508	187159508	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcactgaagccctgtgcccTttcagaaattggtaattgta	8	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:187159508T>C	ENST00000264690.6	+	6	774	c.587T>C	c.(586-588)cTt>cCt	p.L196P	KLKB1_ENST00000513864.1_Missense_Mutation_p.L196P	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	196					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CCCTGTGCCCTTTCAGAAATT	0.498													32	45					0	0	1	0	0	C	187159508	T	C	187159508	3	2	21	1	0	0	0	0	1	0	0	0	8454	1609	56	4	605	4	KLKB1	4	187159508	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	591676	187159508	3994768	190	1611										
PLEKHG4B	153478	broad.mit.edu	37	chr5	155041	155041	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acaaatttgttgacagctgcCagctgaccgcagacctcgac	9	13	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:155041C>T	ENST00000283426.6	+	6	1026	c.976C>T	c.(976-978)Cag>Tag	p.Q326*		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	326					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TGACAGCTGCCAGCTGACCGC	0.577													36	39					0	0	1	0	0	T	155041	C	T	155041	4	4	21	1	0	0	0	0	0	1	0	0	12119	595	21	3	998	3	PLEKHG4B	5	155041	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08		155041	180760219	191	1612										
SLC9A3	6550	broad.mit.edu	37	chr5	476346	476346	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcacgctcccgcttgtacaGcttggccgccttcttgttct	10	15	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:476346G>A	ENST00000264938.3	-	13	2047	c.2038C>T	c.(2038-2040)Ctg>Ttg	p.L680L	CTD-2228K2.7_ENST00000606319.1_RNA|SLC9A3_ENST00000514375.1_Silent_p.L671L|CTD-2228K2.7_ENST00000607286.1_RNA	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	680						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGCTTGTACAGCTTGGCCGCC	0.647													18	46					0	0	1	0	0	A	476346	G	A	476346	2	1	21	1	0	0	0	0	0	0	0	1	14767	962	34	3		3	SLC9A3	5	476346	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	321305	476346	180438914	192	1613										
RXFP3	51289	broad.mit.edu	37	chr5	33937225	33937225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtcaccaacctggcgctgaCggactttcagtttgtgctca	10	13	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:33937225C>T	ENST00000330120.3	+	1	735	c.380C>T	c.(379-381)aCg>aTg	p.T127M		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	127						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CTGGCGCTGACGGACTTTCAG	0.572													54	89					0	0	1	0	0	T	33937225	C	T	33937225	3	4	21	1	0	0	0	0	1	0	0	0	13812	536	19	1	382	1	RXFP3	5	33937225	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	33460879	33937225	146978035	193	1614										
DAB2	1601	broad.mit.edu	37	chr5	39383336	39383336	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aattctgattggtgtcgattTcagagtttagatccactaac	8	7	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:39383336T>C	ENST00000320816.6	-	10	1192	c.725A>G	c.(724-726)gAa>gGa	p.E242G	DAB2_ENST00000339788.6_Intron|DAB2_ENST00000545653.1_Missense_Mutation_p.E221G|DAB2_ENST00000509337.1_Missense_Mutation_p.E221G	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	242					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GGTGTCGATTTCAGAGTTTAG	0.383													49	70					0	0	1	0	0	C	39383336	T	C	39383336	3	2	21	1	0	0	0	0	1	0	0	0	4242	1783	62	4	1607	4	DAB2	5	39383336	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	5446111	39383336	141531924	194	1615										
C7	730	broad.mit.edu	37	chr5	40964971	40964971	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttgttggggaaatgcattgTcagagtgagtggcgtcagtt	15	5	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:40964971T>A	ENST00000313164.9	+	14	2237	c.1878T>A	c.(1876-1878)tgT>tgA	p.C626*		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	626	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AAATGCATTGTCAGAGTGAGT	0.398													59	98					0	0	1	0	0	A	40964971	T	A	40964971	4	1	21	1	0	0	0	0	0	1	0	0	2391	1673	58	4	1932	4	C7	5	40964971	Nonsense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1581635	40964971	139950289	195	1616										
DHX29	54505	broad.mit.edu	37	chr5	54570837	54570837	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagtctgaactgggatgtatTcctaaaagaaatccaaccag	8	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:54570837T>C	ENST00000251636.5	-	15	2577	c.2427_splice	c.e15-1	p.E810_splice	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	810							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TGGGATGTATTCCTAAAAGAA	0.358													38	27					0	0	1	0	0	C	54570837	T	C	54570837	5	2	21	1	0	0	0	0	0	0	1	0	4531	1797	62	4	1732	4	DHX29	5	54570837	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	13605866	54570837	126344423	196	1617										
PDE4D	5144	broad.mit.edu	37	chr5	58476445	58476445	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tatggtggctttgttgatggAtggttggttgcacatgggtg	17	3	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:58476445A>T	ENST00000340635.6	-	5	959	c.784T>A	c.(784-786)Tcc>Acc	p.S262T	PDE4D_ENST00000546160.1_Missense_Mutation_p.S201T|PDE4D_ENST00000507116.1_Missense_Mutation_p.S198T|PDE4D_ENST00000405755.2_Missense_Mutation_p.S140T|PDE4D_ENST00000360047.5_Missense_Mutation_p.S126T|PDE4D_ENST00000502575.1_Missense_Mutation_p.S198T|PDE4D_ENST00000503947.1_5'UTR|PDE4D_ENST00000503258.1_Missense_Mutation_p.S132T|PDE4D_ENST00000502484.2_Missense_Mutation_p.S201T	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	262					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TTGTTGATGGATGGTTGGTTG	0.398													11	19					0	0	1	0	0	T	58476445	A	T	58476445	3	4	21	1	0	0	0	0	1	0	0	0	11688	333	12	4	1689	4	PDE4D	5	58476445	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3905608	58476445	122438815	197	1618										
VCAN	1462	broad.mit.edu	37	chr5	82837257	82837257	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atattacactgatacaacatTagcagtttcaacatttgcga	5	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:82837257T>C	ENST00000265077.3	+	8	9000	c.8435T>C	c.(8434-8436)tTa>tCa	p.L2812S	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000342785.4_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Missense_Mutation_p.L1825S	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2812	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GATACAACATTAGCAGTTTCA	0.458													88	77					0	0	1	0	0	C	82837257	T	C	82837257	3	2	21	1	0	0	0	0	1	0	0	0	17197	1764	61	4	8461	4	VCAN	5	82837257	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	24360812	82837257	98078003	198	1619										
EDIL3	10085	broad.mit.edu	37	chr5	83239262	83239262	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctcctctgtgcagcccagCagctctgaccgcaatgtgat	9	15	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:83239262C>A	ENST00000296591.5	-	11	1837	c.1419G>T	c.(1417-1419)ctG>ctT	p.L473L	EDIL3_ENST00000380138.3_Silent_p.L463L	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	473	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TGCAGCCCAGCAGCTCTGACC	0.483													25	50					4.4004e-07	4.57246e-07	1	1	0	A	83239262	C	A	83239262	2	1	21	1	0	0	0	0	0	0	0	1	4941	697	25	5		5	EDIL3	5	83239262	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	402005	83239262	97675998	199	1620										
NR2F1	7025	broad.mit.edu	37	chr5	92929320	92929320	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagagcctgcaggagaagtcGcagtgcgcactggaggagta	17	8	0	2	rs142689077	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:92929320G>A	ENST00000327111.3	+	3	2731	c.1044G>A	c.(1042-1044)tcG>tcA	p.S348S	NR2F1_ENST00000506162.1_3'UTR	NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	348					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		AGGAGAAGTCGCAGTGCGCAC	0.647													69	110					0	0	1	0	0	A	92929320	G	A	92929320	2	1	21	1	0	0	0	0	0	0	0	1	10674	1074	38	1		1	NR2F1	5	92929320	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9690058	92929320	87985940	200	1621										
SLCO4C1	353189	broad.mit.edu	37	chr5	101627312	101627313	+	Splice_Site	INS	-	-	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggccattaactacaatacctINSaaaaaacagaaaagttgatg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:101627312_101627313insA	ENST00000310954.6	-	2	642		c.e2-2			NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1						cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		CTACAATACCTAAAAAACAGAA	0.312													18	28	---	---	---	---						A	101627313	-	A	101627312	8	5	21	1	0	1	1	0	0	0	1	0	14784	1536	53	0	1868	0	SLCO4C1	5	101627312	Splice_Site	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	8697992	101627312	79287948	201	1622										
FER	2241	broad.mit.edu	37	chr5	108203563	108203563	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tattggcgttgaaaggggcaCagctccatcagaatcagtat	11	8	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:108203563C>T	ENST00000281092.4	+	6	961	c.577C>T	c.(577-579)Cag>Tag	p.Q193*	FER_ENST00000438717.2_Nonsense_Mutation_p.Q18*|FER_ENST00000536402.1_Nonsense_Mutation_p.Q193*	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	193	Important for interaction with membranes containing phosphoinositides.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GAAAGGGGCACAGCTCCATCA	0.403													17	41					0	0	1	0	0	T	108203563	C	T	108203563	4	4	21	1	0	0	0	0	0	1	0	0	5845	479	17	3	591	3	FER	5	108203563	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6576251	108203563	72711697	202	1623										
MCC	4163	broad.mit.edu	37	chr5	112824031	112824031	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgctggacgtgtcgctgctGctgctgctgctgccgctgcc	15	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:112824031G>A	ENST00000408903.3	-	1	496	c.81C>T	c.(79-81)agC>agT	p.S27S		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	555					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TGTcgctgctgctgctgctgc	0.741													24	10					0	0	1	0	0	A	112824031	G	A	112824031	2	1	21	1	0	0	0	0	0	0	0	1	9422	1310	46	3		3	MCC	5	112824031	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4620468	112824031	68091229	203	1624										
SEMA6A	57556	broad.mit.edu	37	chr5	115783143	115783143	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gactctggggtggggagggcCgtcaggtccaggtggtgctg	21	8	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:115783143C>T	ENST00000343348.6	-	19	3046	c.2259G>A	c.(2257-2259)acG>acA	p.T753T	SEMA6A_ENST00000513137.1_Silent_p.T180T|SEMA6A_ENST00000282394.6_Silent_p.T230T|SEMA6A_ENST00000510263.1_Silent_p.T753T|SEMA6A_ENST00000503865.1_Silent_p.T132T|SEMA6A_ENST00000257414.8_Silent_p.T770T	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	753					apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGGGGAGGGCCGTCAGGTCCA	0.632													172	144					0	0	1	0	0	T	115783143	C	T	115783143	2	4	21	1	0	0	0	0	0	0	0	1	14092	639	23	1		1	SEMA6A	5	115783143	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2959112	115783143	65132117	204	1625										
SNX2	6643	broad.mit.edu	37	chr5	122165305	122165305	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	attcacagctgataaaatacTgggaagcattcctacctgaa	7	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:122165305T>C	ENST00000379516.2	+	15	1630	c.1522T>C	c.(1522-1524)Tgg>Cgg	p.W508R	SNX2_ENST00000510372.1_3'UTR|SNX2_ENST00000514949.1_Missense_Mutation_p.W391R	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	508					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		GATAAAATACTGGGAAGCATT	0.343													21	50					0	0	1	0	0	C	122165305	T	C	122165305	3	2	21	1	0	0	0	0	1	0	0	0	14944	1580	55	4	1580	4	SNX2	5	122165305	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	6382162	122165305	58749955	205	1626										
TIFAB	497189	broad.mit.edu	37	chr5	134785404	134785404	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcccttgcggctcagggcctTgaggcagaaggccagcaggg	17	12	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:134785404T>C	ENST00000537858.1	-	2	426	c.226A>G	c.(226-228)Aag>Gag	p.K76E		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	76	FHA.									breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTCAGGGCCTTGAGGCAGAAG	0.662													115	95					0	0	1	0	0	C	134785404	T	C	134785404	3	2	21	1	0	0	0	0	1	0	0	0	15954	1821	63	4	263	4	TIFAB	5	134785404	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	12620099	134785404	46129856	206	1627										
TGFBI	7045	broad.mit.edu	37	chr5	135392371	135392371	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagcatgctggtagctgccaTccagtctgcaggactgacgg	13	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:135392371T>C	ENST00000442011.2	+	12	1726	c.1565T>C	c.(1564-1566)aTc>aCc	p.I522T	TGFBI_ENST00000305126.8_Missense_Mutation_p.I522T	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	522	FAS1 4.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTAGCTGCCATCCAGTCTGCA	0.502													28	63					0	0	1	0	0	C	135392371	T	C	135392371	3	2	21	1	0	0	0	0	1	0	0	0	15879	1435	50	4	1611	4	TGFBI	5	135392371	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	606967	135392371	45522889	207	1628										
PSD2	84249	broad.mit.edu	37	chr5	139221883	139221883	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttatgagacctatatccacCtcctggctatgaaaatcaaa	6	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:139221883C>A	ENST00000274710.3	+	15	2345	c.2140C>A	c.(2140-2142)Ctc>Atc	p.L714I		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	714					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATATCCACCTCCTGGCTAT	0.473													21	52					1.10513e-12	1.18051e-12	1	1	0	A	139221883	C	A	139221883	3	1	21	1	0	0	0	0	1	0	0	0	12695	681	24	5	2194	5	PSD2	5	139221883	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3829512	139221883	41693377	208	1629										
ANKHD1	54882	broad.mit.edu	37	chr5	139906583	139906583	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtcattgccattaagctctCcaaacataaagctgaatctc	5	11	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:139906583C>T	ENST00000297183.6	+	27	5135	c.5011C>T	c.(5011-5013)Cca>Tca	p.P1671S	ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1671S|ANKHD1_ENST00000544120.1_Missense_Mutation_p.P54S|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1671S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTAAGCTCTCCAAACATAAA	0.388													15	77					0	0	1	0	0	T	139906583	C	T	139906583	3	4	21	1	0	0	0	0	1	0	0	0	624	855	30	3	5223	3	ANKHD1	5	139906583	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	684700	139906583	41008677	209	1630										
PCDHA6	0	broad.mit.edu	37	chr5	140208727	140208727	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgataacgtccctgagataGcactgacttccttatccttg	7	11	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140208727G>A	ENST00000529310.1	+	1	1165	c.1051G>A	c.(1051-1053)Gca>Aca	p.A351T	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.A351T|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTGAGATAGCACTGACTTC	0.488													91	80					0	0	1	0	0	A	140208727	G	A	140208727	3	1	21	1	0	0	0	0	1	0	0	0	11574	971	34	3	1053	3	PCDHA6	5	140208727	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	302144	140208727	40706533	210	1631										
PCDHB6	0	broad.mit.edu	37	chr5	140531421	140531421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctgcagtctttcgagttccGcgtgggcgccacagaccgcg	13	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140531421G>A	ENST00000231136.1	+	1	1583	c.1583G>A	c.(1582-1584)cGc>cAc	p.R528H	PCDHB6_ENST00000543635.1_Missense_Mutation_p.R392H	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		528	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGAGTTCCGCGTGGGCGCC	0.657													113	116					0	0	1	0	0	A	140531421	G	A	140531421	3	1	21	1	0	0	0	0	1	0	0	0	11592	1087	38	1	1585	1	PCDHB6	5	140531421	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	322694	140531421	40383839	211	1632										
PCDHB16	0	broad.mit.edu	37	chr5	140564303	140564303	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcagggcggcctcggtgggCcgctgctcgatgcctgaggg	19	12	0	1	rs144790293	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140564303C>T	ENST00000361016.2	+	1	3324	c.2169C>T	c.(2167-2169)ggC>ggT	p.G723G		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		723					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCGGTGGGCCGCTGCTCGA	0.662													152	145					0	0	1	0	0	T	140564303	C	T	140564303	2	4	21	1	0	0	0	0	0	0	0	1	11587	726	26	3		3	PCDHB16	5	140564303	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	32882	140564303	40350957	212	1633										
PCDHB14	0	broad.mit.edu	37	chr5	140604308	140604309	+	Frame_Shift_Del	DEL	AG	AG	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttctgaaaaagcactggacAgagagagccaagccgagtac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140604308_140604309delAG	ENST00000239449.4	+	1	1231_1232	c.1231_1232delAG	c.(1231-1233)afs	p.R411fs	PCDHB14_ENST00000515856.2_Frame_Shift_Del_p.R258fs	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		411	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCACTGGACAGAGAGAGCCAA	0.47													105	115	---	---	---	---						-	140604309	AG	-	140604308	7	5	21	1	0	1	0	1	0	0	0	0	11585	180	7	0	1233	0	PCDHB14	5	140604308	Frame_Shift_Del	DEL	AG	TCGA-N7-A4Y0-01A-12D-A28R-08	40005	140604308	40310952	213	1634										
PCDHB15	0	broad.mit.edu	37	chr5	140627364	140627364	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagggcatctggtggacgtgAgcggcaccgggaccctttcc	15	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140627364A>G	ENST00000231173.3	+	1	2218	c.2218A>G	c.(2218-2220)Agc>Ggc	p.S740G		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		740					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGACGTGAGCGGCACCGG	0.602													207	134					0	0	1	0	0	G	140627364	A	G	140627364	3	3	21	1	0	0	0	0	1	0	0	0	11586	304	11	4	2220	4	PCDHB15	5	140627364	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	23056	140627364	40287896	214	1635										
PCDHGB1	0	broad.mit.edu	37	chr5	140730213	140730213	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tattaatgacaatgcaccacGtttcgttgcaaaaggcattg	8	8	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140730213G>A	ENST00000523390.1	+	1	386	c.386G>A	c.(385-387)cGt>cAt	p.R129H	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGCACCACGTTTCGTTGCA	0.418													35	77					0	0	1	0	0	A	140730213	G	A	140730213	3	1	21	1	0	0	0	0	1	0	0	0	11608	1145	40	1	388	1	PCDHGB1	5	140730213	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	102849	140730213	40185047	215	1636										
PCDHGB7	0	broad.mit.edu	37	chr5	140799074	140799074	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcgccaatgtgagcctgcgcGtgttggtgggcgaccgtaac	16	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140799074G>A	ENST00000398594.2	+	1	1648	c.1648G>A	c.(1648-1650)Gtg>Atg	p.V550M	PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGCGCGTGTTGGTGGG	0.721													23	71					0	0	1	0	0	A	140799074	G	A	140799074	3	1	21	1	0	0	0	0	1	0	0	0	11614	1145	40	1	1650	1	PCDHGB7	5	140799074	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	68861	140799074	40116186	216	1637										
PCDH12	51294	broad.mit.edu	37	chr5	141334689	141334689	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagatgtcgctgccgtctcaGggttgcagaggaggctggtg	18	8	1	2	rs439293		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:141334689G>T	ENST00000231484.3	-	1	3938	c.2728C>A	c.(2728-2730)Ctg>Atg	p.L910M		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	910					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCGTCTCAGGGTTGCAGAG	0.632													36	85					1.96642e-18	2.15299e-18	1	1	0	T	141334689	G	T	141334689	3	4	21	1	0	0	0	0	1	0	0	0	11556	991	35	5	842	5	PCDH12	5	141334689	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	535615	141334689	39580571	217	1638										
GRXCR2	643226	broad.mit.edu	37	chr5	145252292	145252292	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acactgatcctctgagcagtCagcttaggggagcacatctg	11	11	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:145252292C>T	ENST00000377976.1	-	1	239	c.240G>A	c.(238-240)ctG>ctA	p.L80L		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	80										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						TCTGAGCAGTCAGCTTAGGGG	0.517													42	66					0	0	1	0	0	T	145252292	C	T	145252292	2	4	21	1	0	0	0	0	0	0	0	1	6853	813	29	3		3	GRXCR2	5	145252292	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3917603	145252292	35662968	218	1639										
PDGFRB	5159	broad.mit.edu	37	chr5	149509511	149509511	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aactgttccccagcagcgtgGgcggcagctcacgtggacac	13	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:149509511G>A	ENST00000261799.4	-	10	1857	c.1388C>T	c.(1387-1389)cCc>cTc	p.P463L		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	463	Ig-like C2-type 5.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAGCAGCGTGGGCGGCAGCTC	0.612			T	"ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"	"MPD, AML, CMML, CML"						OREG0016927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	90					0	0	1	0	0	A	149509511	G	A	149509511	3	1	21	1	0	0	0	0	1	0	0	0	11708	1232	43	3	1988	3	PDGFRB	5	149509511	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4257219	149509511	31405749	219	1640										
WWC1	23286	broad.mit.edu	37	chr5	167882440	167882440	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaccggagagtgggcacccCgtcccaggggccatttcttc	14	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:167882440C>T	ENST00000265293.4	+	19	3240	c.2738C>T	c.(2737-2739)cCg>cTg	p.P913L	WWC1_ENST00000521089.1_Missense_Mutation_p.P913L|WWC1_ENST00000522140.1_3'UTR	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	913	Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GTGGGCACCCCGTCCCAGGGG	0.622													129	105					0	0	1	0	0	T	167882440	C	T	167882440	3	4	21	1	0	0	0	0	1	0	0	0	17470	652	23	1	2812	1	WWC1	5	167882440	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	18372929	167882440	13032820	220	1641										
MSX2	4488	broad.mit.edu	37	chr5	174151740	174151740	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtggtggccggaccaggcccGgggcctgggggcgccgaggg	23	12	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:174151740G>C	ENST00000239243.6	+	1	205	c.78G>C	c.(76-78)ccG>ccC	p.P26P	MSX2_ENST00000507785.1_Silent_p.P26P	NM_002449.4	NP_002440.2	P35548	MSX2_HUMAN	msh homeobox 2	26					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GACCAGGCCCGGGGCCTGGGG	0.682													5	20					0	0	1	0	0	C	174151740	G	C	174151740	2	2	21	1	0	0	0	0	0	0	0	1	9943	1103	39	5		5	MSX2	5	174151740	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6269300	174151740	6763520	221	1642										
CDHR2	54825	broad.mit.edu	37	chr5	176004718	176004718	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agagacattaatgaccacagGcccacgtttccccagagctt	8	13	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:176004718G>A	ENST00000510636.1	+	14	1705	c.1431G>A	c.(1429-1431)agG>agA	p.R477R	CDHR2_ENST00000506348.1_Silent_p.R477R|CDHR2_ENST00000261944.5_Silent_p.R477R	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	477	Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ATGACCACAGGCCCACGTTTC	0.607													27	59					0	0	1	0	0	A	176004718	G	A	176004718	2	1	21	1	0	0	0	0	0	0	0	1	3141	1194	42	3		3	CDHR2	5	176004718	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1852978	176004718	4910542	222	1643										
NSD1	64324	broad.mit.edu	37	chr5	176696631	176696631	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagctgagatctgccatcctCgagctgttccttccaacatt	7	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:176696631C>T	ENST00000439151.2	+	16	5377	c.5332C>T	c.(5332-5334)Cga>Tga	p.R1778*	NSD1_ENST00000347982.4_Nonsense_Mutation_p.R1509*|NSD1_ENST00000354179.4_Nonsense_Mutation_p.R1509*|NSD1_ENST00000361032.4_Nonsense_Mutation_p.R1675*	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1778	PWWP 2.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding	p.R1778*(2)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CTGCCATCCTCGAGCTGTTCC	0.468			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			50	34					0	0	1	0	0	T	176696631	C	T	176696631	4	4	21	1	0	0	0	0	0	1	0	0	10716	876	31	1	5390	1	NSD1	5	176696631	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	691913	176696631	4218629	223	1644										
FAM193B	54540	broad.mit.edu	37	chr5	176963600	176963600	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggtgctgccggggtggtggGcagcaggtgtgggtggggtg	25	5	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:176963600G>A	ENST00000443375.2	-	5	2054	c.496C>T	c.(496-498)Ccc>Tcc	p.P166S	FAM193B_ENST00000514747.1_Missense_Mutation_p.P279S|FAM193B_ENST00000508298.1_Intron|FAM193B_ENST00000329540.5_5'UTR			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	226										kidney(1)|large_intestine(3)	4						GGGGTGGTGGGCAGCAGGTGT	0.667													9	12					0	0	1	0	0	A	176963600	G	A	176963600	3	1	21	1	0	0	0	0	1	0	0	0	5556	1203	42	3	1897	3	FAM193B	5	176963600	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	266969	176963600	3951660	224	1645										
CANX	821	broad.mit.edu	37	chr5	179146716	179146716	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agatgaagaggccacaaaacCcgaaggctggttagatgatg	13	7	0	5			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:179146716C>A	ENST00000247461.4	+	9	1159	c.959C>A	c.(958-960)cCc>cAc	p.P320H	CANX_ENST00000504734.1_Missense_Mutation_p.P320H|CANX_ENST00000452673.2_Missense_Mutation_p.P320H|CANX_ENST00000415618.2_Missense_Mutation_p.P355H|CANX_ENST00000512607.2_Missense_Mutation_p.P212H	NM_001746.3	NP_001737.1	P27824	CALX_HUMAN	calnexin	320	4 X approximate repeats.|P domain (Extended arm) (By similarity).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|prostate(2)|urinary_tract(3)	22	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCACAAAACCCGAAGGCTGG	0.423													18	17					1.00905e-13	1.08051e-13	1	1	0	A	179146716	C	A	179146716	3	1	21	1	0	0	0	0	1	0	0	0	2636	623	22	5	989	5	CANX	5	179146716	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2183116	179146716	1768544	225	1646										
TUBB2B	347733	broad.mit.edu	37	chr6	3225652	3225653	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgacaccaggtggttgaggtINSccccgtaggtgggggtggtc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:3225652_3225653insC	ENST00000259818.7	-	4	861_862	c.670_671insG	c.(670-672)cctfs	p.P224fs	TUBB2B_ENST00000473006.1_5'UTR	NM_178012.4	NP_821080.1	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B class IIb	224					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			kidney(2)|large_intestine(5)|lung(1)|prostate(1)|skin(1)	10	Ovarian(93;0.0386)	all_hematologic(90;0.108)				GTGGTTGAGGTCCCCGTAGGTG	0.614													44	53	---	---	---	---						C	3225653	-	C	3225652	7	5	21	1	0	1	1	0	0	0	0	0	16816	1667	58	0	670	0	TUBB2B	6	3225652	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08		3225652	167889415	226	1647										
RREB1	6239	broad.mit.edu	37	chr6	7247181	7247181	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccctgaacaggaggagaagCcccccgagaccccggcagag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:7247181delC	ENST00000379938.2	+	12	5035	c.4498delC	c.(4498-4500)ccfs	p.P1501fs	RREB1_ENST00000349384.6_Frame_Shift_Del_p.P1446fs|RREB1_ENST00000334984.6_Intron|RREB1_ENST00000379933.3_Frame_Shift_Del_p.P1446fs	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1446					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGAGGAGAAGCCCCCCGAGAC	0.746													11	3	---	---	---	---						-	7247181	C	-	7247181	7	5	21	1	0	1	0	1	0	0	0	0	13730	739	26	0	4532	0	RREB1	6	7247181	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4021529	7247181	163867886	227	1648										
DSP	1832	broad.mit.edu	37	chr6	7583793	7583793	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcactggttttgatgatccaTtttcaggcaagacagtatct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:7583793delT	ENST00000379802.3	+	24	6639	c.6298delT	c.(6298-6300)ttfs	p.F2100fs	DSP_ENST00000418664.2_Frame_Shift_Del_p.F1501fs	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2100	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGATGATCCATTTTCAGGCAA	0.468													225	156	---	---	---	---						-	7583793	T	-	7583793	7	5	21	1	0	1	0	1	0	0	0	0	4807	1493	52	0	6392	0	DSP	6	7583793	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	336612	7583793	163531274	228	1649										
HIST1H3C	8352	broad.mit.edu	37	chr6	26045754	26045754	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caccggtggcgtgaagaaacCtcatcgctaccgcccgggca	12	15	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:26045754C>A	ENST00000540144.1	+	1	116	c.116C>A	c.(115-117)cCt>cAt	p.P39H		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	39					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						GTGAAGAAACCTCATCGCTAC	0.637													80	50					5.04879e-28	5.6549e-28	1	1	0	A	26045754	C	A	26045754	3	1	21	1	0	0	0	0	1	0	0	0	7197	681	24	5	118	5	HIST1H3C	6	26045754	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	18461961	26045754	145069313	229	1650										
RNF39	80352	broad.mit.edu	37	chr6	30039052	30039052	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgctcccagtccaggtccaCgcgaatgcgccgcggcgggg	15	17	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:30039052C>T	ENST00000244360.6	-	4	1196	c.1099G>A	c.(1099-1101)Gtg>Atg	p.V367M	RNF39_ENST00000376751.3_Intron	NM_025236.3	NP_079512.2	Q9H2S5	RNF39_HUMAN	ring finger protein 39	367	B30.2/SPRY.					cytoplasm	zinc ion binding										TCCAGGTCCACGCGAATGCGC	0.751													4	15					0	0	1	0	0	T	30039052	C	T	30039052	3	4	21	1	0	0	0	0	1	0	0	0	13542	536	19	1	167	1	RNF39	6	30039052	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3993298	30039052	141076015	230	1651										
GNL1	2794	broad.mit.edu	37	chr6	30521243	30521243	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggcaaccacaagagctggcGgggccagatccaccttgttc	12	13	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:30521243G>A	ENST00000376621.3	-	6	1662	c.692C>T	c.(691-693)cCg>cTg	p.P231L		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	231					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						AAGAGCTGGCGGGGCCAGATC	0.542													104	73					0	0	1	0	0	A	30521243	G	A	30521243	3	1	21	1	0	0	0	0	1	0	0	0	6576	1116	39	1	1159	1	GNL1	6	30521243	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	482191	30521243	140593824	231	1652										
LTA	4049	broad.mit.edu	37	chr6	31541415	31541415	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atccacccacacagatggcaTcccccacctagtcctcagcc	5	20	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:31541415T>C	ENST00000454783.1	+	4	821	c.563T>C	c.(562-564)aTc>aCc	p.I188T	LTA_ENST00000418386.2_Missense_Mutation_p.I188T	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	188					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	ACAGATGGCATCCCCCACCTA	0.522													21	357					0	0	1	0	0	C	31541415	T	C	31541415	3	2	21	1	0	0	0	0	1	0	0	0	9112	1435	50	4	573	4	LTA	6	31541415	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1020172	31541415	139573652	232	1653										
TNXB	7148	broad.mit.edu	37	chr6	32065702	32065702	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgaagcaaggactgggggctCggtgcctgggggacagccac	18	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:32065702C>T	ENST00000375244.3	-	2	475	c.274G>A	c.(274-276)Gag>Aag	p.E92K	TNXB_ENST00000375247.2_Missense_Mutation_p.E92K|TNXB_ENST00000479795.1_Missense_Mutation_p.E92K			P22105	TENX_HUMAN	tenascin XB	92					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACTGGGGGCTCGGTGCCTGGG	0.607													28	17					0	0	1	0	0	T	32065702	C	T	32065702	3	4	21	1	0	0	0	0	1	0	0	0	16405	893	31	1	14611	1	TNXB	6	32065702	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	524287	32065702	139049365	233	1654										
C6orf10	10665	broad.mit.edu	37	chr6	32261771	32261772	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atctggattttggaacaagaINStttttttgcaagttcttcat					rs560505	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:32261771_32261772insT	ENST00000375015.4	-	26	875_876	c.675_676insA	c.(673-678)aacttgfs	p.N225fs	C6orf10_ENST00000533191.1_Frame_Shift_Ins_p.N224fs|C6orf10_ENST00000442822.2_Frame_Shift_Ins_p.N217fs|C6orf10_ENST00000375007.4_Frame_Shift_Ins_p.N224fs|C6orf10_ENST00000447241.2_Frame_Shift_Ins_p.N226fs|C6orf10_ENST00000527965.1_Frame_Shift_Ins_p.N210fs			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	226						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						TTGGAACAAGATTTTTTTGCAA	0.337													61	58	---	---	---	---						T	32261772	-	T	32261771	7	5	21	1	0	1	1	0	0	0	0	0	2331	333	12	0	1016	0	C6orf10	6	32261771	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	196069	32261771	138853296	234	1655										
HLA-DMB	3109	broad.mit.edu	37	chr6	32904929	32904929	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgctttgaccctaattccaTccatctgccatacacttact	3	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:32904929T>C	ENST00000416244.2	-	3	836	c.642A>G	c.(640-642)ggA>ggG	p.G214G	HLA-DMB_ENST00000418107.2_Intron			P28068	DMB_HUMAN	major histocompatibility complex, class II, DM beta	0	Connecting peptide (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						CCTAATTCCATCCATCTGCCA	0.507													5	98					0	0	1	0	0	C	32904929	T	C	32904929	2	2	21	1	0	0	0	0	0	0	0	1	7239	1450	50	4		4	HLA-DMB	6	32904929	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	643158	32904929	138210138	235	1656										
HLA-DPA1	3113	broad.mit.edu	37	chr6	33037547	33037547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaactcctccagatgccagaCggtctccttcttgtccagat	7	14	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:33037547C>T	ENST00000419277.1	-	3	346	c.217G>A	c.(217-219)Gtc>Atc	p.V73I	HLA-DPA1_ENST00000428995.1_Missense_Mutation_p.V73I|HLA-DPA1_ENST00000463066.1_5'UTR	NM_001242524.1|NM_001242525.1	NP_001229453.1|NP_001229454.1	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP alpha 1	73	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			kidney(5)|large_intestine(1)|lung(6)|prostate(1)|skin(2)	15						AGATGCCAGACGGTCTCCTTC	0.458													41	28					0	0	1	0	0	T	33037547	C	T	33037547	3	4	21	1	0	0	0	0	1	0	0	0	7242	536	19	1	577	1	HLA-DPA1	6	33037547	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	132618	33037547	138077520	236	1657										
VPS52	6293	broad.mit.edu	37	chr6	33231322	33231322	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctttgctgtcatctgcagccCgctcctaagggaagacaaag	10	12	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:33231322C>T	ENST00000445902.2	-	17	1951	c.1733G>A	c.(1732-1734)cGg>cAg	p.R578Q	VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.R453Q|VPS52_ENST00000478934.1_5'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	578					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						ATCTGCAGCCCGCTCCTAAGG	0.512													26	35					0	0	1	0	0	T	33231322	C	T	33231322	3	4	21	1	0	0	0	0	1	0	0	0	17273	652	23	1	454	1	VPS52	6	33231322	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	193775	33231322	137883745	237	1658										
ITPR3	3710	broad.mit.edu	37	chr6	33630351	33630351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagcaggagaagttcctgaCgtgtgacgagtacaagggca	16	7	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:33630351C>T	ENST00000374316.5	+	9	1818	c.758C>T	c.(757-759)aCg>aTg	p.T253M	ITPR3_ENST00000605930.1_Missense_Mutation_p.T253M			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	253	MIR 3.				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						AAGTTCCTGACGTGTGACGAG	0.632													25	18					0	0	1	0	0	T	33630351	C	T	33630351	3	4	21	1	0	0	0	0	1	0	0	0	7965	536	19	1	788	1	ITPR3	6	33630351	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	399029	33630351	137484716	238	1659										
FANCE	2178	broad.mit.edu	37	chr6	35424067	35424067	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagttaagactggcgaggaCggttcgaatctggatgatgc	15	7	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:35424067C>T	ENST00000229769.2	+	2	977	c.792C>T	c.(790-792)gaC>gaT	p.D264D		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	264	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						CTGGCGAGGACGGTTCGAATC	0.498			"N, F, S"			"AML, leukemia"		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				94	222					0	0	1	0	0	T	35424067	C	T	35424067	2	4	21	1	0	0	0	0	0	0	0	1	5698	535	19	1		1	FANCE	6	35424067	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1793716	35424067	135691000	239	1660										
PXT1	222659	broad.mit.edu	37	chr6	36359628	36359628	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagacaaaatgatctagtgcAtctctgccatcctgttgaag	8	9	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:36359628A>G	ENST00000454782.2	-	5	807	c.324T>C	c.(322-324)gaT>gaC	p.D108D	RP1-50J22.4_ENST00000411643.1_RNA	NM_152990.3	NP_694535.2	Q8NFP0	PXT1_HUMAN	peroxisomal, testis specific 1	25						peroxisome											GATCTAGTGCATCTCTGCCAT	0.323													37	93					0	0	1	0	0	G	36359628	A	G	36359628	2	3	21	1	0	0	0	0	0	0	0	1	12904	214	8	4		4	PXT1	6	36359628	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	935561	36359628	134755439	240	1661										
TAF8	129685	broad.mit.edu	37	chr6	42036324	42036324	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaacagacagacacagagaaCcttgctcttcatatcagcat	7	11	3	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:42036324C>T	ENST00000372977.3	+	7	777	c.759C>T	c.(757-759)aaC>aaT	p.N253N	TAF8_ENST00000456846.2_Silent_p.N253N|TAF8_ENST00000465926.1_Silent_p.N177N|TAF8_ENST00000494547.1_Silent_p.N253N|TAF8_ENST00000372982.4_Silent_p.N253N	NM_138572.2	NP_612639.2	Q7Z7C8	TAF8_HUMAN	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	253					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ACACAGAGAACCTTGCTCTTC	0.532													80	212					0	0	1	0	0	T	42036324	C	T	42036324	2	4	21	1	0	0	0	0	0	0	0	1	15590	506	18	3		3	TAF8	6	42036324	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5676696	42036324	129078743	241	1662										
KLC4	89953	broad.mit.edu	37	chr6	43034148	43034148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccagtacgcagcccaaggtCgctatgaggtggccgtgcca	13	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:43034148C>T	ENST00000394056.2	+	6	1171	c.676C>T	c.(676-678)Cgc>Tgc	p.R226C	KLC4_ENST00000394058.1_Missense_Mutation_p.R226C|KLC4_ENST00000259708.3_Missense_Mutation_p.R244C|KLC4_ENST00000347162.5_Missense_Mutation_p.R226C|KLC4_ENST00000453940.2_Missense_Mutation_p.R149C|KLC4_ENST00000458460.2_Missense_Mutation_p.R226C|KLC4_ENST00000479388.1_Missense_Mutation_p.R226C			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	226						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGCCCAAGGTCGCTATGAGGT	0.597													43	84					0	0	1	0	0	T	43034148	C	T	43034148	3	4	21	1	0	0	0	0	1	0	0	0	8378	884	31	1	748	1	KLC4	6	43034148	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	997824	43034148	128080919	242	1663										
KLHL31	401265	broad.mit.edu	37	chr6	53517031	53517031	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttctgcgttgcggccgcccgCggcgtacacgagcccgttga	14	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:53517031C>T	ENST00000370905.3	-	3	1410	c.1270G>A	c.(1270-1272)Gcg>Acg	p.A424T	KLHL31_ENST00000407079.1_Missense_Mutation_p.A424T	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					CGGCCGCCCGCGGCGTACACG	0.647													41	109					0	0	1	0	0	T	53517031	C	T	53517031	3	4	21	1	0	0	0	0	1	0	0	0	8427	768	27	1	638	1	KLHL31	6	53517031	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	10482883	53517031	117598036	243	1664										
LRRC1	55227	broad.mit.edu	37	chr6	53787465	53787465	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggcgagccactccacacccAggggagttaaagcacatgaa	11	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:53787465A>G	ENST00000370888.1	+	14	1726	c.1449A>G	c.(1447-1449)ccA>ccG	p.P483P		NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	483						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		CTCCACACCCAGGGGAGTTAA	0.413													76	217					0	0	1	0	0	G	53787465	A	G	53787465	2	3	21	1	0	0	0	0	0	0	0	1	9010	175	7	4		4	LRRC1	6	53787465	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	270434	53787465	117327602	244	1665										
SLC17A5	26503	broad.mit.edu	37	chr6	74363524	74363524	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccgccgcttaccggcttcgGcccgtggggcgcccggtaga	15	17	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:74363524G>A	ENST00000355773.5	-	1	354	c.86C>T	c.(85-87)gCc>gTc	p.A29V	SLC17A5_ENST00000393019.3_Missense_Mutation_p.A29V	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	29					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ACCGGCTTCGGCCCGTGGGGC	0.726													13	4					0	0	1	0	0	A	74363524	G	A	74363524	3	1	21	1	0	0	0	0	1	0	0	0	14474	1203	42	3	1445	3	SLC17A5	6	74363524	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	20576059	74363524	96751543	245	1666										
MYO6	4646	broad.mit.edu	37	chr6	76624710	76624710	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cacctatgcaacagccatgcTgcagagtctgttaaagtaga	9	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:76624710T>C	ENST00000369981.3	+	35	4121	c.3842T>C	c.(3841-3843)cTg>cCg	p.L1281P	MYO6_ENST00000369985.4_Missense_Mutation_p.L1257P|MYO6_ENST00000369975.1_Missense_Mutation_p.L1248P|MYO6_ENST00000369977.3_Missense_Mutation_p.L1280P			Q9UM54	MYO6_HUMAN	myosin VI	1289					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		ACAGCCATGCTGCAGAGTCTG	0.512													22	13					0	0	1	0	0	C	76624710	T	C	76624710	3	2	21	1	0	0	0	0	1	0	0	0	10128	1580	55	4	3973	4	MYO6	6	76624710	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2261186	76624710	94490357	246	1667										
PHIP	55023	broad.mit.edu	37	chr6	79711725	79711726	+	Frame_Shift_Ins	INS	-	-	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggttaccatcaacatcaaccINSaaaaaagggggaggcataag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:79711725_79711726insA	ENST00000275034.4	-	17	1936_1937	c.1769_1770insT	c.(1768-1770)tgtfs	p.C590fs		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	590					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CAACATCAACCAAAAAAGGGGG	0.426													38	95	---	---	---	---						A	79711726	-	A	79711725	7	5	21	1	0	1	1	0	0	0	0	0	11889	593	21	0	3791	0	PHIP	6	79711725	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	3087015	79711725	91403342	247	1668										
DOPEY1	23033	broad.mit.edu	37	chr6	83806836	83806836	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acttggaaaacttaataaggTatgtctgtattatccatttc	6	6	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:83806836T>C	ENST00000349129.2	+	3	398		c.e3+2		DOPEY1_ENST00000369739.3_Splice_Site|DOPEY1_ENST00000536812.1_Splice_Site|DOPEY1_ENST00000237163.5_Splice_Site	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1						protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTTAATAAGGTATGTCTGTAT	0.308													117	81					0	0	1	0	0	C	83806836	T	C	83806836	5	2	21	1	0	0	0	0	0	0	1	0	4734	1652	57	4	142	4	DOPEY1	6	83806836	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4095111	83806836	87308231	248	1669										
ZNF292	23036	broad.mit.edu	37	chr6	87970974	87970974	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaaaaaatgtctcacaaaatAaaaaaaggaaagttgaaaaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:87970974delA	ENST00000369577.3	+	8	7670	c.7627delA	c.(7627-7629)aafs	p.K2544fs	ZNF292_ENST00000339907.4_Frame_Shift_Del_p.K2539fs	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CTCACAAAATAAAAAAAGGAA	0.358													37	40	---	---	---	---						-	87970974	A	-	87970974	7	5	21	1	0	1	0	1	0	0	0	0	17882	363	13	0	7657	0	ZNF292	6	87970974	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4164138	87970974	83144093	249	1670										
POU3F2	5454	broad.mit.edu	37	chr6	99283719	99283719	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcttcaagaacatgtgcaagCtgaagcctttgttgaacaag	10	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:99283719C>T	ENST00000328345.5	+	1	1140	c.970C>T	c.(970-972)Ctg>Ttg	p.L324L		NM_005604.3	NP_005595.2	P20265	PO3F2_HUMAN	POU class 3 homeobox 2	324	POU-specific.				positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity	p.L324L(1)		endometrium(2)|large_intestine(3)|lung(5)	10		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		CATGTGCAAGCTGAAGCCTTT	0.587													237	163					0	0	1	0	0	T	99283719	C	T	99283719	2	4	21	1	0	0	0	0	0	0	0	1	12320	796	28	3		3	POU3F2	6	99283719	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	11312745	99283719	71831348	250	1671										
SIM1	6492	broad.mit.edu	37	chr6	100896035	100896035	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccttacgcaaatggtgcgcGcagcgcaggtggaaggtgtc	16	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:100896035G>A	ENST00000369208.3	-	8	1619	c.837C>T	c.(835-837)tgC>tgT	p.C279C	SIM1_ENST00000262901.4_Silent_p.C279C			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	279	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AATGGTGCGCGCAGCGCAGGT	0.622													12	28					0	0	1	0	0	A	100896035	G	A	100896035	2	1	21	1	0	0	0	0	0	0	0	1	14377	1079	38	1		1	SIM1	6	100896035	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1612316	100896035	70219032	251	1672										
GRIK2	2898	broad.mit.edu	37	chr6	102372596	102372596	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagctctcatgcagcaaggTatacgattcagcctgctatt	10	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:102372596T>C	ENST00000369138.1	+	12	2357		c.e12+2		GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000369134.4_Splice_Site|GRIK2_ENST00000318991.6_Splice_Site|GRIK2_ENST00000421544.1_Splice_Site|GRIK2_ENST00000413795.1_Splice_Site	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGCAGCAAGGTATACGATTCA	0.498													16	45					0	0	1	0	0	C	102372596	T	C	102372596	5	2	21	1	0	0	0	0	0	0	1	0	6814	1652	57	4	1915	4	GRIK2	6	102372596	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1476561	102372596	68742471	252	1673										
AIM1	202	broad.mit.edu	37	chr6	107008716	107008716	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggcagttacagagggcgacAgttcctattgtcacctgcag	12	10	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:107008716A>C	ENST00000369066.3	+	17	5157	c.4670A>C	c.(4669-4671)cAg>cCg	p.Q1557P	AIM1_ENST00000535438.1_Missense_Mutation_p.Q376P	NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1557	Beta/gamma crystallin 'Greek key' 12.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGAGGGCGACAGTTCCTATTG	0.403													87	57					0	0	1	0	0	C	107008716	A	C	107008716	3	2	21	1	0	0	0	0	1	0	0	0	427	188	7	4	4736	4	AIM1	6	107008716	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4636120	107008716	64106351	253	1674										
SLC16A10	117247	broad.mit.edu	37	chr6	111409147	111409147	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccatgagccccccgaaccCcccgagggcggctggggctg	14	19	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:111409147C>T	ENST00000368851.5	+	1	367	c.192C>T	c.(190-192)ccC>ccT	p.P64P		NM_018593.4	NP_061063.2	Q8TF71	MOT10_HUMAN	solute carrier family 16 (aromatic amino acid transporter), member 10	64					aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)	12		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		CCCCCGAACCCCCCGAGGGCG	0.731													16	35					0	0	1	0	0	T	111409147	C	T	111409147	2	4	21	1	0	0	0	0	0	0	0	1	14457	610	22	3		3	SLC16A10	6	111409147	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4400431	111409147	59705920	254	1675										
PTPRK	5796	broad.mit.edu	37	chr6	128410948	128410948	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagatggttcacaacatgcTgaggggctttggggtccatg	15	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:128410948T>C	ENST00000368227.3	-	8	1718	c.1352A>G	c.(1351-1353)cAg>cGg	p.Q451R	PTPRK_ENST00000368215.3_Missense_Mutation_p.Q451R|PTPRK_ENST00000368207.3_Missense_Mutation_p.Q451R|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368210.3_Missense_Mutation_p.Q451R|PTPRK_ENST00000368213.5_Missense_Mutation_p.Q451R|PTPRK_ENST00000532331.1_Missense_Mutation_p.Q451R|PTPRK_ENST00000368226.4_Missense_Mutation_p.Q451R			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	451	Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CACAACATGCTGAGGGGCTTT	0.468													91	48					0	0	1	0	0	C	128410948	T	C	128410948	3	2	21	1	0	0	0	0	1	0	0	0	12856	1580	55	4	3084	4	PTPRK	6	128410948	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	17001801	128410948	42704119	255	1676										
ENPP1	5167	broad.mit.edu	37	chr6	132171156	132171156	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttgcaaaggtcgctgtttcGagagaacatttgggaactgt	13	6	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:132171156G>A	ENST00000360971.2	+	3	360	c.340G>A	c.(340-342)Gag>Aag	p.E114K		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	114	SMB 1.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity	p.E62*(1)		autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TCGCTGTTTCGAGAGAACATT	0.383													67	53					0	0	1	0	0	A	132171156	G	A	132171156	3	1	21	1	0	0	0	0	1	0	0	0	5157	1059	37	1	350	1	ENPP1	6	132171156	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3760208	132171156	38943911	256	1677										
HBS1L	10767	broad.mit.edu	37	chr6	135287507	135287507	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctattgtagaaccaccgtaaCgtagcatgaacctccccagc	7	14	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:135287507C>G	ENST00000367837.5	-	17	2209	c.2003G>C	c.(2002-2004)cGt>cCt	p.R668P	HBS1L_ENST00000367826.2_Missense_Mutation_p.R626P|HBS1L_ENST00000415177.2_Missense_Mutation_p.R603P|HBS1L_ENST00000527578.1_Missense_Mutation_p.R504P|HBS1L_ENST00000367824.4_Missense_Mutation_p.R504P|HBS1L_ENST00000445176.2_Missense_Mutation_p.R392P	NM_001145158.1|NM_006620.3	NP_001138630.1|NP_006611.1	Q9Y450	HBS1L_HUMAN	HBS1-like (S. cerevisiae)	668					signal transduction		GTP binding|GTPase activity|translation elongation factor activity	p.R668P(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	20	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		ACCACCGTAACGTAGCATGAA	0.378													45	126					0	0	1	0	0	G	135287507	C	G	135287507	3	3	21	1	0	0	0	0	1	0	0	0	7027	536	19	5	59	5	HBS1L	6	135287507	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3116351	135287507	35827560	257	1678										
AHI1	54806	broad.mit.edu	37	chr6	135811796	135811796	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agacctgacaagttttttctTcagttttttcttttcacgca	5	9	4	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:135811796T>C	ENST00000367800.4	-	3	316	c.100A>G	c.(100-102)Aag>Gag	p.K34E	AHI1_ENST00000367798.2_Missense_Mutation_p.K34E|AHI1_ENST00000534469.1_Missense_Mutation_p.K34E|AHI1_ENST00000457866.2_Missense_Mutation_p.K34E|AHI1_ENST00000327035.6_Missense_Mutation_p.K34E|AHI1_ENST00000488690.2_Missense_Mutation_p.K34E|AHI1_ENST00000528103.1_Missense_Mutation_p.K34E	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	34						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		AGTTTTTTCTTCAGTTTTTTC	0.348													39	96					0	0	1	0	0	C	135811796	T	C	135811796	3	2	21	1	0	0	0	0	1	0	0	0	410	1792	62	4	3647	4	AHI1	6	135811796	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	524289	135811796	35303271	258	1679										
MAP3K5	4217	broad.mit.edu	37	chr6	136990430	136990430	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttgtaattaccaactttccGgagctcaaaggaagattcaa	8	8	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:136990430G>C	ENST00000359015.4	-	8	1717	c.1357C>G	c.(1357-1359)Cgg>Ggg	p.R453G		NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	453					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CCAACTTTCCGGAGCTCAAAG	0.393													41	105					0	0	1	0	0	C	136990430	G	C	136990430	3	2	21	1	0	0	0	0	1	0	0	0	9302	1115	39	5	2859	5	MAP3K5	6	136990430	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1178634	136990430	34124637	259	1680										
SHPRH	257218	broad.mit.edu	37	chr6	146209222	146209222	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgctttaattaagaatctgTgtacaatagtaggtctaaaa	7	4	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:146209222T>C	ENST00000367503.3	-	29	5299	c.4901A>G	c.(4900-4902)cAc>cGc	p.H1634R	SHPRH_ENST00000438092.2_Missense_Mutation_p.H1634R|SHPRH_ENST00000275233.7_Missense_Mutation_p.H1630R|SHPRH_ENST00000367505.2_Missense_Mutation_p.H1630R	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1630	Helicase C-terminal.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TAAGAATCTGTGTACAATAGT	0.323													9	34					0	0	1	0	0	C	146209222	T	C	146209222	3	2	21	1	0	0	0	0	1	0	0	0	14345	1696	59	4	187	4	SHPRH	6	146209222	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	9218792	146209222	24905845	260	1681										
SYNE1	23345	broad.mit.edu	37	chr6	152738148	152738148	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctctctacttctgctgcgtgGtcctggaagggaagagagag	14	9	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:152738148G>T	ENST00000367255.5	-	41	6025	c.5424C>A	c.(5422-5424)gaC>gaA	p.D1808E	SYNE1_ENST00000448038.1_Missense_Mutation_p.D1815E|SYNE1_ENST00000423061.1_Missense_Mutation_p.D1815E|SYNE1_ENST00000265368.4_Missense_Mutation_p.D1808E|SYNE1_ENST00000341594.5_Missense_Mutation_p.D1845E	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1808					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCTGCGTGGTCCTGGAAGG	0.483										HNSCC(10;0.0054)			95	66					2.56585e-57	2.91483e-57	1	1	0	T	152738148	G	T	152738148	3	4	21	1	0	0	0	0	1	0	0	0	15501	1252	44	5	21466	5	SYNE1	6	152738148	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6528926	152738148	18376919	261	1682										
MYCT1	80177	broad.mit.edu	37	chr6	153043291	153043291	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cacttcccacagtctgagccGtcctgactactggtccagta	8	15	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:153043291G>A	ENST00000367245.5	+	2	619	c.611G>A	c.(610-612)cGt>cAt	p.R204H	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	204						nucleus		p.R204H(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		AGTCTGAGCCGTCCTGACTAC	0.532													57	88					0	0	1	0	0	A	153043291	G	A	153043291	3	1	21	1	0	0	0	0	1	0	0	0	10069	1145	40	1	617	1	MYCT1	6	153043291	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	305143	153043291	18071776	262	1683										
EZR	7430	broad.mit.edu	37	chr6	159188477	159188477	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acacggggggtggtgggggcGggggtgctgtcatcaccagg					rs139613796		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:159188477delG	ENST00000367075.3	-	13	1580	c.1412delC	c.(1411-1413)cgfs	p.P476fs	EZR_ENST00000337147.7_Frame_Shift_Del_p.P476fs|EZR_ENST00000392177.4_Frame_Shift_Del_p.P444fs	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	476	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TGGTGGGGGCGGGGGTGCTGT	0.597			T	ROS1	NSCLC								100	84	---	---	---	---						-	159188477	G	-	159188477	7	5	21	1	0	1	0	1	0	0	0	0	5363	1116	39	0	356	0	EZR	6	159188477	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6145186	159188477	11926590	263	1684										
IGF2R	3482	broad.mit.edu	37	chr6	160526039	160526039	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaaagggaagtccagctctGcacagcagaagacagtgagc	14	9	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:160526039G>A	ENST00000356956.1	+	48	7547	c.7399G>A	c.(7399-7401)Gca>Aca	p.A2467T	IGF2R_ENST00000475584.1_Intron	NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	2467					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GTCCAGCTCTGCACAGCAGAA	0.597													17	40					0	0	1	0	0	A	160526039	G	A	160526039	3	1	21	1	0	0	0	0	1	0	0	0	7619	1319	46	3	7589	3	IGF2R	6	160526039	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1337562	160526039	10589028	264	1685										
PSMB1	5689	broad.mit.edu	37	chr6	170844432	170844432	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgaagacatctttcaccagcCgcatggctctgtccaaggac	9	13	3	2	rs150833808		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:170844432C>T	ENST00000262193.6	-	6	700	c.602G>A	c.(601-603)cGg>cAg	p.R201Q	PSMB1_ENST00000462957.1_5'UTR	NM_002793.3	NP_002784.1	P20618	PSB1_HUMAN	proteasome (prosome, macropain) subunit, beta type, 1	201					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	TTTCACCAGCCGCATGGCTCT	0.512													67	49					0	0	1	0	0	T	170844432	C	T	170844432	3	4	21	1	0	0	0	0	1	0	0	0	12722	652	23	1	127	1	PSMB1	6	170844432	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	10318393	170844432	270635	265	1686										
MAD1L1	8379	broad.mit.edu	37	chr7	1976422	1976422	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcgcaggagcccgcgcagtcGctcgcactccgcctgcagct	13	18	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:1976422G>A	ENST00000406869.1	-	17	2265	c.1708C>T	c.(1708-1710)Cga>Tga	p.R570*	MAD1L1_ENST00000402746.1_Nonsense_Mutation_p.R478*|MAD1L1_ENST00000265854.7_Nonsense_Mutation_p.R570*|MAD1L1_ENST00000399654.2_Nonsense_Mutation_p.R570*			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	570					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		CCGCGCAGTCGCTCGCACTCC	0.692													8	11					0	0	1	0	0	A	1976422	G	A	1976422	4	1	21	1	0	0	0	0	0	1	0	0	9192	1095	38	1	460	1	MAD1L1	7	1976422	Nonsense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08		1976422	157162241	266	1687										
TTYH3	80727	broad.mit.edu	37	chr7	2687615	2687615	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctgggctacctgggcctgCtgctgctggacgtcatcatc	14	13	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:2687615C>T	ENST00000258796.7	+	5	854	c.649C>T	c.(649-651)Ctg>Ttg	p.L217L	TTYH3_ENST00000403167.1_Silent_p.L46L|TTYH3_ENST00000407643.1_Intron|TTYH3_ENST00000477439.1_3'UTR	NM_025250.2	NP_079526.1	Q9C0H2	TTYH3_HUMAN	tweety family member 3	217						chloride channel complex|plasma membrane	chloride channel activity			kidney(1)|large_intestine(3)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	17		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CCTGGGCCTGCTGCTGCTGGA	0.706													7	91					0	0	1	0	0	T	2687615	C	T	2687615	2	4	21	1	0	0	0	0	0	0	0	1	16802	796	28	3		3	TTYH3	7	2687615	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	711193	2687615	156451048	267	1688										
FSCN1	6624	broad.mit.edu	37	chr7	5645075	5645075	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgaaggcctcggcggaaacCgtggaccccgcctcgctctg	13	16	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:5645075C>T	ENST00000382361.3	+	5	1566	c.1452C>T	c.(1450-1452)acC>acT	p.T484T	FSCN1_ENST00000340250.6_Silent_p.T463T	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	484					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		CGGCGGAAACCGTGGACCCCG	0.662													5	3					0	0	1	0	0	T	5645075	C	T	5645075	2	4	21	1	0	0	0	0	0	0	0	1	6101	639	23	1		1	FSCN1	7	5645075	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2957460	5645075	153493588	268	1689										
DGKB	1607	broad.mit.edu	37	chr7	14217687	14217687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcaggagcactgagccagccGccggccagcacttttcaggc	13	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:14217687G>A	ENST00000403951.2	-	24	2634	c.2215C>T	c.(2215-2217)Cgg>Tgg	p.R739W	DGKB_ENST00000258767.5_Missense_Mutation_p.R739W|DGKB_ENST00000444700.2_Missense_Mutation_p.R720W|DGKB_ENST00000399322.3_Missense_Mutation_p.R739W|DGKB_ENST00000407950.1_Missense_Mutation_p.R731W|DGKB_ENST00000406247.3_Missense_Mutation_p.R739W|DGKB_ENST00000402815.1_Missense_Mutation_p.R738W			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	739					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TGAGCCAGCCGCCGGCCAGCA	0.507													39	61					0	0	1	0	0	A	14217687	G	A	14217687	3	1	21	1	0	0	0	0	1	0	0	0	4494	1086	38	1	226	1	DGKB	7	14217687	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	8572612	14217687	144920976	269	1690										
NFE2L3	9603	broad.mit.edu	37	chr7	26192151	26192151	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagcggtggtggtcggccggCggcggcctcctgcacctcac	16	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:26192151C>T	ENST00000056233.3	+	1	292	c.33C>T	c.(31-33)ggC>ggT	p.G11G		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	11					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						GGTCGGCCGGCGGCGGCCTCC	0.756													13	17					0	0	1	0	0	T	26192151	C	T	26192151	2	4	21	1	0	0	0	0	0	0	0	1	10415	755	27	1		1	NFE2L3	7	26192151	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	11974464	26192151	132946512	270	1691										
PLEKHA8	84725	broad.mit.edu	37	chr7	30085829	30085829	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctctgtcttgctcccagttcAttctgtagataatacacgca	6	12	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:30085829A>G	ENST00000449726.1	+	3	511	c.161A>G	c.(160-162)cAt>cGt	p.H54R	PLEKHA8_ENST00000396257.2_Missense_Mutation_p.H54R|PLEKHA8_ENST00000396259.1_Missense_Mutation_p.H54R|PLEKHA8_ENST00000258679.7_Missense_Mutation_p.H54R|PLEKHA8_ENST00000483799.1_3'UTR	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	54	PH.				protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						CTCCCAGTTCATTCTGTAGAT	0.512													49	80					0	0	1	0	0	G	30085829	A	G	30085829	3	3	21	1	0	0	0	0	1	0	0	0	12109	217	8	4	171	4	PLEKHA8	7	30085829	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3893678	30085829	129052834	271	1692										
ANLN	54443	broad.mit.edu	37	chr7	36461586	36461588	+	In_Frame_Del	DEL	CTT	CTT	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagaagctgaagcagaaagaCttcttctaattgcaagtaag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:36461586_36461588delCTT	ENST00000265748.2	+	13	2505_2507	c.2284_2286delCTT	c.(2284-2286)del	p.L764del	ANLN_ENST00000396068.2_In_Frame_Del_p.L727del	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	764	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						AGCAGAAAGACTTCTTCTAATTG	0.379													37	53	---	---	---	---						-	36461588	CTT	-	36461586	7	5	21	1	0	1	0	1	0	0	0	0	688	565	20	0	2334	0	ANLN	7	36461586	In_Frame_Del	DEL	CTT	TCGA-N7-A4Y0-01A-12D-A28R-08	6375757	36461586	122677077	272	1693										
C7orf25	79020	broad.mit.edu	37	chr7	42949408	42949408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atggcttttagggtgtctccCgtcccaaaaattgttaatga	9	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:42949408C>T	ENST00000350427.4	-	2	1367	c.1092G>A	c.(1090-1092)acG>acA	p.T364T	C7orf25_ENST00000447342.1_Silent_p.T364T|C7orf25_ENST00000431882.2_Silent_p.T422T|C7orf25_ENST00000438029.1_Silent_p.T364T|PSMA2_ENST00000442788.1_3'UTR			Q9BPX7	CG025_HUMAN	chromosome 7 open reading frame 25	364										endometrium(6)|kidney(1)|large_intestine(7)|lung(2)|skin(1)	17						GGGTGTCTCCCGTCCCAAAAA	0.433													41	37					0	0	1	0	0	T	42949408	C	T	42949408	2	4	21	1	0	0	0	0	0	0	0	1	2396	639	23	1		1	C7orf25	7	42949408	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6487822	42949408	116189255	273	1694										
DBNL	28988	broad.mit.edu	37	chr7	44098476	44098476	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgaaggttttgcccactgcaGgggtcaacatgtgcttccct	11	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:44098476G>T	ENST00000468694.1	+	9	783		c.e9-1		DBNL_ENST00000497184.1_Intron|DBNL_ENST00000452943.1_Intron|DBNL_ENST00000456905.1_Intron|DBNL_ENST00000440166.1_Intron|DBNL_ENST00000490734.2_Intron|DBNL_ENST00000448521.1_Intron|DBNL_ENST00000494774.1_Intron	NM_001122956.1	NP_001116428.1	Q9UJU6	DBNL_HUMAN	drebrin-like						activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			breast(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|stomach(1)	12						GCCCACTGCAGGGGTCAACAT	0.602													22	20					8.10497e-08	8.47206e-08	1	1	0	T	44098476	G	T	44098476	5	4	21	1	0	0	0	0	0	0	1	0	4279	1014	35	5	790	5	DBNL	7	44098476	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1149068	44098476	115040187	274	1695										
AEBP1	165	broad.mit.edu	37	chr7	44146234	44146234	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtccttggaggggtcccccAggccgcccaagaaggggaag	16	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:44146234A>G	ENST00000223357.3	+	2	648	c.343A>G	c.(343-345)Agg>Ggg	p.R115G		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	115	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						GGGGTCCCCCAGGCCGCCCAA	0.577													15	5					0	0	1	0	0	G	44146234	A	G	44146234	3	3	21	1	0	0	0	0	1	0	0	0	348	179	7	4	349	4	AEBP1	7	44146234	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	47758	44146234	114992429	275	1696										
IGFBP1	3484	broad.mit.edu	37	chr7	45930298	45930298	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcgaaggctctccatgtcacCaacatcaaaaaatggaaggt	8	10	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:45930298C>A	ENST00000275525.3	+	2	797	c.501C>A	c.(499-501)acC>acA	p.T167T	IGFBP1_ENST00000468955.1_Silent_p.T167T|IGFBP1_ENST00000457280.1_Silent_p.T167T	NM_000596.2	NP_000587.1	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	167						extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						TCCATGTCACCAACATCAAAA	0.527											OREG0018048	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	64					3.62531e-18	3.9594e-18	1	1	0	A	45930298	C	A	45930298	2	1	21	1	0	0	0	0	0	0	0	1	7621	581	21	5		5	IGFBP1	7	45930298	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1784064	45930298	113208365	276	1697										
ABCA13	154664	broad.mit.edu	37	chr7	48284175	48284175	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atttatttttgccctcagatTacagcatctgtggaaattgc	7	8	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:48284175T>C	ENST00000435803.1	+	11	1289	c.1265T>C	c.(1264-1266)tTa>tCa	p.L422S		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	422					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GCCCTCAGATTACAGCATCTG	0.393													12	23					0	0	1	0	0	C	48284175	T	C	48284175	3	2	21	1	0	0	0	0	1	0	0	0	31	1764	61	4	1136	4	ABCA13	7	48284175	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2353877	48284175	110854488	277	1698										
COBL	23242	broad.mit.edu	37	chr7	51258732	51258732	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagggctcacacgcacaacaGctttttgtgtccgcaggtaa	10	12	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:51258732G>T	ENST00000395542.2	-	4	684	c.500C>A	c.(499-501)gCt>gAt	p.A167D	COBL_ENST00000395540.2_Missense_Mutation_p.A167D|COBL_ENST00000265136.7_Missense_Mutation_p.A167D|COBL_ENST00000441453.1_Missense_Mutation_p.A167D			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	167										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ACGCACAACAGCTTTTTGTGT	0.488													8	30					0.000442599	0.000448739	1	1	0	T	51258732	G	T	51258732	3	4	21	1	0	0	0	0	1	0	0	0	3676	971	34	5	3325	5	COBL	7	51258732	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2974557	51258732	107879931	278	1699										
HIP1	3092	broad.mit.edu	37	chr7	75182877	75182877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctgccatactgcttacaggCctcggtcagtgctggagata	11	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:75182877C>T	ENST00000336926.6	-	22	2196	c.2170G>A	c.(2170-2172)Gcc>Acc	p.A724T	HIP1_ENST00000434438.2_Missense_Mutation_p.A724T	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	724					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TGCTTACAGGCCTCGGTCAGT	0.562			T	PDGFRB	CMML								23	38					0	0	1	0	0	T	75182877	C	T	75182877	3	4	21	1	0	0	0	0	1	0	0	0	7154	739	26	3	983	3	HIP1	7	75182877	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	23924145	75182877	83955786	279	1700										
CD36	948	broad.mit.edu	37	chr7	80276069	80276069	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caagaaaaatgggctgtgacCggaactgtgggctcatcgct	13	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:80276069C>T	ENST00000435819.1	+	6	697	c.13C>T	c.(13-15)Cgg>Tgg	p.R5W	CD36_ENST00000441109.2_3'UTR|CD36_ENST00000447544.2_Missense_Mutation_p.R5W|CD36_ENST00000544133.1_Missense_Mutation_p.R5W|CD36_ENST00000432207.1_Missense_Mutation_p.R5W|CD36_ENST00000394788.3_Missense_Mutation_p.R5W|CD36_ENST00000534394.1_Intron|CD36_ENST00000309881.7_Missense_Mutation_p.R5W|CD36_ENST00000538969.1_Missense_Mutation_p.R5W|CD36_ENST00000433696.2_Missense_Mutation_p.R5W			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	5					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						GGGCTGTGACCGGAACTGTGG	0.468													50	53					0	0	1	0	0	T	80276069	C	T	80276069	3	4	21	1	0	0	0	0	1	0	0	0	3029	643	23	1	15	1	CD36	7	80276069	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5093192	80276069	78862594	280	1701										
CROT	54677	broad.mit.edu	37	chr7	86990793	86990793	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgcgggtcctgcagctcatTttgaacactactggcctcca	9	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:86990793T>C	ENST00000331536.3	+	5	513	c.328T>C	c.(328-330)Ttt>Ctt	p.F110L	CROT_ENST00000419147.2_Missense_Mutation_p.F138L|CROT_ENST00000442291.1_Missense_Mutation_p.F110L	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	110					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGCAGCTCATTTTGAACACTA	0.418													43	67					0	0	1	0	0	C	86990793	T	C	86990793	3	2	21	1	0	0	0	0	1	0	0	0	3917	1841	64	4	426	4	CROT	7	86990793	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	6714724	86990793	72147870	281	1702										
CALCR	799	broad.mit.edu	37	chr7	93106930	93106930	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ataggacaatactccagccgGtgtgtcatcccagcacagcc	9	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:93106930G>A	ENST00000359558.2	-	6	609	c.310C>T	c.(310-312)Ccg>Tcg	p.P104S	CALCR_ENST00000421592.1_Missense_Mutation_p.P86S|CALCR_ENST00000426151.1_Missense_Mutation_p.P86S|CALCR_ENST00000394441.1_Missense_Mutation_p.P86S|CALCR_ENST00000360249.4_Missense_Mutation_p.P86S	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	86					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ACTCCAGCCGGTGTGTCATCC	0.418													25	32					0	0	1	0	0	A	93106930	G	A	93106930	3	1	21	1	0	0	0	0	1	0	0	0	2597	1261	44	3	1260	3	CALCR	7	93106930	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6116137	93106930	66031733	282	1703										
TECPR1	25851	broad.mit.edu	37	chr7	97846804	97846804	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttggcccggacagagatatgGtcccagcctccctggaagga	13	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:97846804G>A	ENST00000447648.2	-	26	3695	c.3396C>T	c.(3394-3396)gaC>gaT	p.D1132D	TECPR1_ENST00000379795.3_Silent_p.D1134D			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	1132						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CAGAGATATGGTCCCAGCCTC	0.682													11	11					0	0	1	0	0	A	97846804	G	A	97846804	2	1	21	1	0	0	0	0	0	0	0	1	15801	1252	44	3		3	TECPR1	7	97846804	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4739874	97846804	61291859	283	1704										
ZCWPW1	55063	broad.mit.edu	37	chr7	99998670	99998670	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcgccacggggaagtcctcGccatcactgttgctgtgctg	13	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:99998670G>A	ENST00000398027.2	-	18	2161	c.1914C>T	c.(1912-1914)ggC>ggT	p.G638G	ZCWPW1_ENST00000360951.4_3'UTR|ZCWPW1_ENST00000490721.1_Silent_p.G467G|ZCWPW1_ENST00000324725.6_Silent_p.G467G	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	638							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGAAGTCCTCGCCATCACTGT	0.597													15	31					0	0	1	0	0	A	99998670	G	A	99998670	2	1	21	1	0	0	0	0	0	0	0	1	17654	1074	38	1		1	ZCWPW1	7	99998670	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2151866	99998670	59139993	284	1705										
GIGYF1	64599	broad.mit.edu	37	chr7	100283633	100283633	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcctctagcccttcggaagGttcctcctcctcctccaacc	5	20	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:100283633G>A	ENST00000275732.5	-	9	2227	c.1018C>T	c.(1018-1020)Cct>Tct	p.P340S	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	340										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCTTCGGAAGGTTCCTCCTCC	0.682													33	42					0	0	1	0	0	A	100283633	G	A	100283633	3	1	21	1	0	0	0	0	1	0	0	0	6418	1261	44	3	2153	3	GIGYF1	7	100283633	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	284963	100283633	58855030	285	1706										
PIK3CG	5294	broad.mit.edu	37	chr7	106508511	106508511	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcactgacgtcagcaacgtgCacgacgatgagctggagttc	12	11	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:106508511C>T	ENST00000359195.3	+	2	815	c.505C>T	c.(505-507)Cac>Tac	p.H169Y	PIK3CG_ENST00000440650.2_Missense_Mutation_p.H169Y|PIK3CG_ENST00000496166.1_Missense_Mutation_p.H169Y	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	169					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						CAGCAACGTGCACGACGATGA	0.677													30	18					0	0	1	0	0	T	106508511	C	T	106508511	3	4	21	1	0	0	0	0	1	0	0	0	11963	710	25	3	507	3	PIK3CG	7	106508511	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6224878	106508511	52630152	286	1707										
HBP1	26959	broad.mit.edu	37	chr7	106826902	106826902	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctggccttcaactgtctggCactgttttttgaaaggtaaa	9	9	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:106826902C>T	ENST00000222574.4	+	5	823	c.637C>T	c.(637-639)Cac>Tac	p.H213Y	HBP1_ENST00000468410.1_Missense_Mutation_p.H213Y|HBP1_ENST00000485846.1_Missense_Mutation_p.H213Y	NM_012257.3	NP_036389.2	O60381	HBP1_HUMAN	HMG-box transcription factor 1	213	AXH.				cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						AACTGTCTGGCACTGTTTTTT	0.398													53	84					0	0	1	0	0	T	106826902	C	T	106826902	3	4	21	1	0	0	0	0	1	0	0	0	7025	710	25	3	651	3	HBP1	7	106826902	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	318391	106826902	52311761	287	1708										
DOCK4	9732	broad.mit.edu	37	chr7	111423966	111423966	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagtagcaattaatgaaacGccactttcccgccatgtttc	6	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:111423966G>A	ENST00000428084.1	-	34	3743	c.3471C>T	c.(3469-3471)ggC>ggT	p.G1157G	DOCK4_ENST00000437633.1_Silent_p.G1148G|DOCK4_ENST00000494651.2_Silent_p.G31G			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1148	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TTAATGAAACGCCACTTTCCC	0.408													6	7					0	0	1	0	0	A	111423966	G	A	111423966	2	1	21	1	0	0	0	0	0	0	0	1	4716	1074	38	1		1	DOCK4	7	111423966	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4597064	111423966	47714697	288	1709										
KCND2	3751	broad.mit.edu	37	chr7	120386010	120386010	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aatgccaatgtatcaggaagCcatcaaggtagtatacaaga	9	7	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:120386010C>T	ENST00000331113.4	+	5	2609	c.1644C>T	c.(1642-1644)agC>agT	p.S548S		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	548					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TATCAGGAAGCCATCAAGGTA	0.443													23	52					0	0	1	0	0	T	120386010	C	T	120386010	2	4	21	1	0	0	0	0	0	0	0	1	8062	738	26	3		3	KCND2	7	120386010	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	8962044	120386010	38752653	289	1710										
ZNF800	168850	broad.mit.edu	37	chr7	127014143	127014143	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggaagggggtgaagattctAcagaatctgctggttcaact	13	6	3	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:127014143A>G	ENST00000393313.1	-	5	1838	c.1247T>C	c.(1246-1248)gTa>gCa	p.V416A	ZNF800_ENST00000393312.1_Missense_Mutation_p.V416A|ZNF800_ENST00000265827.3_Missense_Mutation_p.V416A			Q2TB10	ZN800_HUMAN	zinc finger protein 800	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TGAAGATTCTACAGAATCTGC	0.358													28	41					0	0	1	0	0	G	127014143	A	G	127014143	3	3	21	1	0	0	0	0	1	0	0	0	18217	391	14	4	755	4	ZNF800	7	127014143	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	6628133	127014143	32124520	290	1711										
IMPDH1	3614	broad.mit.edu	37	chr7	128037026	128037026	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggtgggggtacttctgtttGatgtaatgcaccatggcgat	14	6	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:128037026G>A	ENST00000338791.6	-	11	1475	c.1125C>T	c.(1123-1125)atC>atT	p.I375I	IMPDH1_ENST00000378717.4_Silent_p.I306I|IMPDH1_ENST00000480861.1_Silent_p.I285I|IMPDH1_ENST00000470772.1_Silent_p.I289I|IMPDH1_ENST00000348127.6_Silent_p.I339I|IMPDH1_ENST00000419067.2_Silent_p.I342I|IMPDH1_ENST00000343214.4_Silent_p.I265I|IMPDH1_ENST00000496200.1_Silent_p.I265I|IMPDH1_ENST00000354269.5_Silent_p.I365I	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	290					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	ACTTCTGTTTGATGTAATGCA	0.562													35	57					0	0	1	0	0	A	128037026	G	A	128037026	2	1	21	1	0	0	0	0	0	0	0	1	7769	1280	45	3		3	IMPDH1	7	128037026	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1022883	128037026	31101637	291	1712										
SMO	6608	broad.mit.edu	37	chr7	128843292	128843292	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtgccgtatacatgcccaaGtgtgagaatgaccgggtgga	14	8	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:128843292G>T	ENST00000249373.3	+	2	679	c.399G>T	c.(397-399)aaG>aaT	p.K133N		NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	133	FZ.				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						ACATGCCCAAGTGTGAGAATG	0.672			Mis		skin basal cell								3	3					0.115264	0.11566	1	1	0	T	128843292	G	T	128843292	3	4	21	1	0	0	0	0	1	0	0	0	14853	1020	36	5	405	5	SMO	7	128843292	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	806266	128843292	30295371	292	1713										
AKR1B15	441282	broad.mit.edu	37	chr7	134252969	134252969	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	attgatgcagaatatcgccaCattgactgtgcctatttcta	7	9	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:134252969C>T	ENST00000457545.2	+	4	470	c.210C>T	c.(208-210)caC>caT	p.H70H	AKR1B15_ENST00000423958.1_Silent_p.H42H	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	70							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						AATATCGCCACATTGACTGTG	0.453													40	52					0	0	1	0	0	T	134252969	C	T	134252969	2	4	21	1	0	0	0	0	0	0	0	1	465	477	17	3		3	AKR1B15	7	134252969	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5409677	134252969	24885694	293	1714										
DGKI	9162	broad.mit.edu	37	chr7	137339501	137339501	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcttggtgaccttgagcctcCttctcgaaatgttggtttac	9	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:137339501C>A	ENST00000453654.1	-	0	354				DGKI_ENST00000424189.2_Nonsense_Mutation_p.G239*|DGKI_ENST00000288490.5_Nonsense_Mutation_p.G239*|DGKI_ENST00000446122.1_Nonsense_Mutation_p.G239*			O75912	DGKI_HUMAN	diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CTTGAGCCTCCTTCTCGAAAT	0.338													21	36					1.66031e-10	1.76069e-10	1	1	0	A	137339501	C	A	137339501	1	1	21	1	0	0	0	0	0	0	0	0	4499	690	24	5		5	DGKI	7	137339501	Translation_Start_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3086532	137339501	21799162	294	1715										
KIAA1549	57670	broad.mit.edu	37	chr7	138522791	138522791	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggggtaacccagcccagggcCctgcagtccccggtggggga	17	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:138522791C>T	ENST00000440172.1	-	20	5713	c.5665G>A	c.(5665-5667)Ggc>Agc	p.G1889S	KIAA1549_ENST00000422774.1_Missense_Mutation_p.G1905S|TMEM213_ENST00000413208.1_3'UTR|KIAA1549_ENST00000242365.4_Missense_Mutation_p.G1839S	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1905						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AGCCCAGGGCCCTGCAGTCCC	0.622			O	BRAF	pilocytic astrocytoma								13	11					0	0	1	0	0	T	138522791	C	T	138522791	3	4	21	1	0	0	0	0	1	0	0	0	8285	623	22	3	143	3	KIAA1549	7	138522791	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1183290	138522791	20615872	295	1716										
BRAF	673	broad.mit.edu	37	chr7	140482927	140482927	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgagccaggtaatgaggcaGggggggtagcagacaaacct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:140482927delG	ENST00000288602.6	-	10	1268	c.1208delC	c.(1207-1209)ctfs	p.P403fs		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	403					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TAATGAGGCAGGGGGGGTAGC	0.428		61	"Mis, T, O"	"AKAP9, KIAA1549"	"melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				15	33	---	---	---	---						-	140482927	G	-	140482927	7	5	21	1	0	1	0	1	0	0	0	0	1498	1000	35	0	1128	0	BRAF	7	140482927	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1960136	140482927	18655736	296	1717										
OR6V1	346517	broad.mit.edu	37	chr7	142749858	142749858	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgagccgggctatgtgtgtcCagctggctggggctgcctgg	18	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:142749858C>T	ENST00000418316.1	+	1	442	c.421C>T	c.(421-423)Cag>Tag	p.Q141*		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TATGTGTGTCCAGCTGGCTGG	0.587													6	90					0	0	1	0	0	T	142749858	C	T	142749858	4	4	21	1	0	0	0	0	0	1	0	0	11257	595	21	3	423	3	OR6V1	7	142749858	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2266931	142749858	16388805	297	1718										
ZYX	7791	broad.mit.edu	37	chr7	143087016	143087016	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagcctggccgagatgagacTgtgcgagtggtcgccctgga	17	10	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:143087016T>C	ENST00000322764.5	+	9	1905	c.1560T>C	c.(1558-1560)acT>acC	p.T520T	ZYX_ENST00000392910.2_Silent_p.T363T|ZYX_ENST00000449423.2_Silent_p.T433T	NM_001010972.1|NM_003461.4	NP_001010972.1|NP_003452.1	Q15942	ZYX_HUMAN	zyxin	520	LIM zinc-binding 3.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)	17	Melanoma(164;0.205)					GAGATGAGACTGTGCGAGTGG	0.602													37	42					0	0	1	0	0	C	143087016	T	C	143087016	2	2	21	1	0	0	0	0	0	0	0	1	18293	1567	55	4		4	ZYX	7	143087016	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	337158	143087016	16051647	298	1719										
OR2A14	135941	broad.mit.edu	37	chr7	143826815	143826815	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcatctttgcagcctgcgtgTtcatcctggtggggccactc	11	13	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:143826815T>A	ENST00000408899.2	+	1	665	c.610T>A	c.(610-612)Ttc>Atc	p.F204I		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					AGCCTGCGTGTTCATCCTGGT	0.567													121	139					0	0	1	0	0	A	143826815	T	A	143826815	3	1	21	1	0	0	0	0	1	0	0	0	11023	1725	60	4	612	4	OR2A14	7	143826815	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	739799	143826815	15311848	299	1720										
CNTNAP2	26047	broad.mit.edu	37	chr7	147914501	147914501	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaccagcagaactcccacccGgacctggcacaggaggagat	12	14	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:147914501G>A	ENST00000361727.3	+	19	3648	c.3132G>A	c.(3130-3132)ccG>ccA	p.P1044P	CNTNAP2_ENST00000538075.1_Silent_p.P103P	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1044					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.P1044P(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACTCCCACCCGGACCTGGCAC	0.562										HNSCC(39;0.1)			51	66					0	0	1	0	0	A	147914501	G	A	147914501	2	1	21	1	0	0	0	0	0	0	0	1	3670	1103	39	1		1	CNTNAP2	7	147914501	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4087686	147914501	11224162	300	1721										
TMEM176B	28959	broad.mit.edu	37	chr7	150490215	150490215	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctctacactcctccttctgCcattggttctcttgacttcg	6	15	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:150490215C>T	ENST00000447204.2	-	5	933	c.561G>A	c.(559-561)tgG>tgA	p.W187*	TMEM176B_ENST00000492607.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000434545.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000429904.2_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000326442.5_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000450753.2_Nonsense_Mutation_p.W150*	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	187					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCTTCTGCCATTGGTTCT	0.527													27	58					0	0	1	0	0	T	150490215	C	T	150490215	4	4	21	1	0	0	0	0	0	1	0	0	16152	740	26	3	263	3	TMEM176B	7	150490215	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2575714	150490215	8648448	301	1722										
CHPF2	54480	broad.mit.edu	37	chr7	150935414	150935415	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctggtgctgacccctcccINSggggggctcctatagggggg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:150935414_150935415insG	ENST00000035307.2	+	4	3479_3480	c.1966_1967insG	c.(1966-1968)gggfs	p.G656fs	CHPF2_ENST00000495645.1_Frame_Shift_Ins_p.G648fs	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	656	Gly/Pro-rich.					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						TGACCCCTCCCGGGGGGCTCCT	0.678													16	20	---	---	---	---						G	150935415	-	G	150935414	7	5	21	1	0	1	1	0	0	0	0	0	3391	643	23	0	1980	0	CHPF2	7	150935414	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	445199	150935414	8203249	302	1723										
NUB1	51667	broad.mit.edu	37	chr7	151046250	151046250	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acgttgcaaggcaattgagcGtggaacaggaaatgacaatt	12	6	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:151046250G>A	ENST00000568733.1	+	3	347	c.281G>A	c.(280-282)cGt>cAt	p.R94H	NUB1_ENST00000566856.1_Missense_Mutation_p.R70H|NUB1_ENST00000413040.2_Missense_Mutation_p.R94H|NUB1_ENST00000355851.4_Missense_Mutation_p.R70H			Q9Y5A7	NUB1_HUMAN	negative regulator of ubiquitin-like proteins 1	70					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding			endometrium(1)|large_intestine(7)|lung(3)	11			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		GCAATTGAGCGTGGAACAGGA	0.373													38	56					0	0	1	0	0	A	151046250	G	A	151046250	3	1	21	1	0	0	0	0	1	0	0	0	10761	1145	40	1	215	1	NUB1	7	151046250	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	110836	151046250	8092413	303	1724										
ERICH1	157697	broad.mit.edu	37	chr8	623411	623411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcctccccggagtctgcaCcctcttcctccccagcccat	5	23	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:623411C>T	ENST00000262109.7	-	4	1018	c.941G>A	c.(940-942)gGt>gAt	p.G314D	ERICH1_ENST00000522706.1_Missense_Mutation_p.G220D	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	314	Glu-rich.									endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		GGAGTCTGCACCCTCTTCCTC	0.567													62	229					0	0	1	0	0	T	623411	C	T	623411	3	4	21	1	0	0	0	0	1	0	0	0	5258	507	18	3	402	3	ERICH1	8	623411	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08		623411	145740611	304	1725										
DLGAP2	9228	broad.mit.edu	37	chr8	1581004	1581004	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgattgcaggtgagcgaggcGgagatcaatgggcaattcga	16	6	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:1581004G>A	ENST00000421627.2	+	5	1496	c.1362G>A	c.(1360-1362)gcG>gcA	p.A454A		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	533					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding	p.A476A(1)		breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGAGCGAGGCGGAGATCAATG	0.572													27	23					0	0	1	0	0	A	1581004	G	A	1581004	2	1	21	1	0	0	0	0	0	0	0	1	4588	1103	39	1		1	DLGAP2	8	1581004	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	957593	1581004	144783018	305	1726										
SPAG11B	10407	broad.mit.edu	37	chr8	7308689	7308690	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccacacagatcctaaatgaINSgggtcctcgagcctcccggt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:7308689_7308690insG	ENST00000297498.2	-	3	412_413	c.246_247insC	c.(244-249)cccattfs	p.I83fs	SPAG11B_ENST00000458665.1_Intron|SPAG11B_ENST00000398462.2_Intron|SPAG11B_ENST00000359758.5_Intron|SPAG11B_ENST00000528168.1_Frame_Shift_Ins_p.I30fs|SPAG11B_ENST00000361111.2_Intron	NM_016512.3	NP_057596.1	Q08648	SG11B_HUMAN	sperm associated antigen 11B	83					spermatogenesis	extracellular region				large_intestine(2)|lung(3)|urinary_tract(1)	6				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		ATCCTAAATGAGGGTCCTCGAG	0.46													80	65	---	---	---	---						G	7308690	-	G	7308689	7	5	21	1	0	1	1	0	0	0	0	0	15032	304	11	0	277	0	SPAG11B	8	7308689	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	5727685	7308689	139055333	306	1727										
MTUS1	57509	broad.mit.edu	37	chr8	17611442	17611442	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagaaacggacccggtctcGcatgctgagttagaagaact	12	10	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:17611442G>A	ENST00000381869.3	-	2	2348	c.1875C>T	c.(1873-1875)tgC>tgT	p.C625C	MTUS1_ENST00000262102.6_Silent_p.C625C|MTUS1_ENST00000519263.1_Silent_p.C625C|MTUS1_ENST00000381862.3_Silent_p.C625C	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	625						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		ACCCGGTCTCGCATGCTGAGT	0.433													79	219					0	0	1	0	0	A	17611442	G	A	17611442	2	1	21	1	0	0	0	0	0	0	0	1	10012	1079	38	1		1	MTUS1	8	17611442	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	10302753	17611442	128752580	307	1728										
PSD3	23362	broad.mit.edu	37	chr8	18729144	18729145	+	Frame_Shift_Ins	INS	-	-	TC													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgggagctcacctttccctgINStctctctctggtttaggtgt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:18729144_18729145insTC	ENST00000440756.2	-	3	1331_1332	c.1229_1230insGA	c.(1228-1230)gagfs	p.E410fs	PSD3_ENST00000523619.1_Frame_Shift_Ins_p.E345fs|PSD3_ENST00000327040.8_Frame_Shift_Ins_p.E410fs			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	410					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACCTTTCCCTGTCTCTCTCTGG	0.45													77	64	---	---	---	---						TC	18729145	-	TC	18729144	7	5	21	1	0	1	1	0	0	0	0	0	12696	1368	48	0	2005	0	PSD3	8	18729144	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	1117702	18729144	127634878	308	1729										
BMP1	649	broad.mit.edu	37	chr8	22034617	22034617	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cactcggccagaccgggaccGccacgtttccatcgttcgtg	11	16	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:22034617G>A	ENST00000306385.5	+	5	1365	c.695G>A	c.(694-696)cGc>cAc	p.R232H	BMP1_ENST00000397816.3_Missense_Mutation_p.R232H|BMP1_ENST00000397814.3_Missense_Mutation_p.R232H|BMP1_ENST00000306349.8_Missense_Mutation_p.R232H|BMP1_ENST00000354870.5_Missense_Mutation_p.R232H	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	232	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GACCGGGACCGCCACGTTTCC	0.647													7	28					0	0	1	0	0	A	22034617	G	A	22034617	3	1	21	1	0	0	0	0	1	0	0	0	1455	1087	38	1	713	1	BMP1	8	22034617	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3305473	22034617	124329405	309	1730										
BMP1	649	broad.mit.edu	37	chr8	22035142	22035142	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaaatggtgcttccttcccaTgttcccttgagtcctccatt	7	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:22035142T>C	ENST00000354870.5	+	6	1059	c.793T>C	c.(793-795)Tgt>Cgt	p.C265R	BMP1_ENST00000397816.3_Intron|BMP1_ENST00000306385.5_Intron|BMP1_ENST00000397814.3_Intron|BMP1_ENST00000306349.8_Intron			P13497	BMP1_HUMAN	bone morphogenetic protein 1	0	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TTCCTTCCCATGTTCCCTTGA	0.612													138	326					0	0	1	0	0	C	22035142	T	C	22035142	3	2	21	1	0	0	0	0	1	0	0	0	1455	1479	51	4		4	BMP1	8	22035142	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	525	22035142	124328880	310	1731										
EBF2	64641	broad.mit.edu	37	chr8	25715915	25715915	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agttggccatggggacattgCtgtagccattcatactgttg	12	8	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:25715915C>T	ENST00000520164.1	-	14	1985	c.1448G>A	c.(1447-1449)aGc>aAc	p.S483N	EBF2_ENST00000408929.3_Missense_Mutation_p.S335N|EBF2_ENST00000535548.1_Missense_Mutation_p.S214N	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	483	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGGGACATTGCTGTAGCCATT	0.517													38	120					0	0	1	0	0	T	25715915	C	T	25715915	3	4	21	1	0	0	0	0	1	0	0	0	4907	797	28	3	291	3	EBF2	8	25715915	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3680773	25715915	120648107	311	1732										
PNMA2	10687	broad.mit.edu	37	chr8	26365217	26365217	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccagcggccatagccatctCgttcctctggctcttcgata	8	15	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:26365217C>T	ENST00000522362.2	-	3	1949	c.1055G>A	c.(1054-1056)cGa>cAa	p.R352Q		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	352					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		ATAGCCATCTCGTTCCTCTGG	0.522													55	212					0	0	1	0	0	T	26365217	C	T	26365217	3	4	21	1	0	0	0	0	1	0	0	0	12201	884	31	1	43	1	PNMA2	8	26365217	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	649302	26365217	119998805	312	1733										
DPYSL2	1808	broad.mit.edu	37	chr8	26481666	26481666	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtttctttctagttgaccaCgttgttcctgagcctgggac	10	10	2	2	rs113199330	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:26481666C>T	ENST00000311151.5	+	4	733	c.321C>T	c.(319-321)caC>caT	p.H107H	DPYSL2_ENST00000523027.1_Silent_p.H71H|DPYSL2_ENST00000521913.1_Silent_p.H71H	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	107					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		TAGTTGACCACGTTGTTCCTG	0.532													16	104					0	0	1	0	0	T	26481666	C	T	26481666	2	4	21	1	0	0	0	0	0	0	0	1	4773	535	19	1		1	DPYSL2	8	26481666	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	116449	26481666	119882356	313	1734										
FBXO16	157574	broad.mit.edu	37	chr8	28314409	28314409	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaacatttcagcatccagagCtggtccagctcagcaaggtt	9	11	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:28314409C>T	ENST00000380254.2	-	5	529	c.381G>A	c.(379-381)caG>caA	p.Q127Q	FBXO16_ENST00000346498.2_Silent_p.Q115Q|FBXO16_ENST00000518734.1_Silent_p.Q115Q|FBXO16_ENST00000517436.1_5'UTR	NM_001258211.1|NM_172366.3	NP_001245140.1|NP_758954.1	Q8IX29	FBX16_HUMAN	F-box protein 16	127	F-box.									large_intestine(2)|ovary(1)	3		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		GCATCCAGAGCTGGTCCAGCT	0.423													89	27					0	0	1	0	0	T	28314409	C	T	28314409	2	4	21	1	0	0	0	0	0	0	0	1	5761	796	28	3		3	FBXO16	8	28314409	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1832743	28314409	118049613	314	1735										
FZD3	7976	broad.mit.edu	37	chr8	28384902	28384902	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcgctatttcataggattgAtttcaatcatttgcctctcg	6	10	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:28384902A>G	ENST00000240093.3	+	5	1103	c.625A>G	c.(625-627)Att>Gtt	p.I209V	FZD3_ENST00000537916.1_Missense_Mutation_p.I209V	NM_017412.3	NP_059108.1	Q9NPG1	FZD3_HUMAN	frizzled family receptor 3	209					canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(15)|ovary(1)|prostate(1)|skin(1)	41		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		CATAGGATTGATTTCAATCAT	0.363													34	155					0	0	1	0	0	G	28384902	A	G	28384902	3	3	21	1	0	0	0	0	1	0	0	0	6165	333	12	4	635	4	FZD3	8	28384902	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	70493	28384902	117979120	315	1736										
GSR	2936	broad.mit.edu	37	chr8	30539472	30539473	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgagtcccactgtcccaataINSggggggtggctgaagaccac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:30539472_30539473insG	ENST00000221130.5	-	11	1349_1350	c.1259_1260insC	c.(1258-1260)catfs	p.H420fs	GSR_ENST00000537535.1_Frame_Shift_Ins_p.H338fs|GSR_ENST00000546342.1_Frame_Shift_Ins_p.H391fs|GSR_ENST00000541648.1_Frame_Shift_Ins_p.H367fs|GSR_ENST00000414019.1_Frame_Shift_Ins_p.H377fs	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	420					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	CTGTCCCAATAGGGGGGTGGCT	0.441													26	126	---	---	---	---						G	30539473	-	G	30539472	7	5	21	1	0	1	1	0	0	0	0	0	6868	407	15	0	320	0	GSR	8	30539472	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	2154570	30539472	115824550	316	1737										
GSR	2936	broad.mit.edu	37	chr8	30560725	30560725	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcttgggatcactcgtgaaGgctgcatggccacggatgat	15	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:30560725G>T	ENST00000221130.5	-	5	615	c.525C>A	c.(523-525)gcC>gcA	p.A175A	GSR_ENST00000546342.1_Silent_p.A175A|GSR_ENST00000541648.1_Silent_p.A175A|GSR_ENST00000537535.1_Silent_p.A175A|GSR_ENST00000414019.1_Silent_p.A132A	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	175					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	CACTCGTGAAGGCTGCATGGC	0.483													13	198					4.3838e-07	4.56061e-07	1	1	0	T	30560725	G	T	30560725	2	4	21	1	0	0	0	0	0	0	0	1	6868	987	35	5		5	GSR	8	30560725	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	21253	30560725	115803297	317	1738										
GPR124	25960	broad.mit.edu	37	chr8	37693106	37693106	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcctccatccagctgccccCgagtctattctcatcccttc	6	19	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:37693106C>T	ENST00000412232.2	+	13	1881	c.1868C>T	c.(1867-1869)cCg>cTg	p.P623L	GPR124_ENST00000315215.7_Intron	NM_032777.9	NP_116166.9	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	623					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CAGCTGCCCCCGAGTCTATTC	0.647													82	298					0	0	1	0	0	T	37693106	C	T	37693106	3	4	21	1	0	0	0	0	1	0	0	0	6677	652	23	1	1897	1	GPR124	8	37693106	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7132381	37693106	108670916	318	1739										
HTRA4	203100	broad.mit.edu	37	chr8	38835513	38835513	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgggaagatcatctgacctTcgggctggagagtttgtggt	15	7	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:38835513T>C	ENST00000302495.4	+	4	913	c.813T>C	c.(811-813)ctT>ctC	p.L271L		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	271	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			CATCTGACCTTCGGGCTGGAG	0.517													52	168					0	0	1	0	0	C	38835513	T	C	38835513	2	2	21	1	0	0	0	0	0	0	0	1	7499	1770	62	4		4	HTRA4	8	38835513	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1142407	38835513	107528509	319	1740										
AP3M2	10947	broad.mit.edu	37	chr8	42022614	42022614	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acaattactgctgagatccaGggggtgattgatgcctgtgt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:42022614delG	ENST00000518421.1	+	6	900	c.609delG	c.(607-609)cafs	p.Q203fs	AP3M2_ENST00000174653.3_Frame_Shift_Del_p.Q203fs|AP3M2_ENST00000396926.3_Frame_Shift_Del_p.Q203fs|AP3M2_ENST00000520685.1_Intron|AP3M2_ENST00000517922.1_Frame_Shift_Del_p.Q203fs	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	203	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			CTGAGATCCAGGGGGTGATTG	0.443													19	89	---	---	---	---						-	42022614	G	-	42022614	7	5	21	1	0	1	0	1	0	0	0	0	744	991	35	0	623	0	AP3M2	8	42022614	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3187101	42022614	104341408	320	1741										
SLC20A2	6575	broad.mit.edu	37	chr8	42275398	42275398	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccagccacagggacggtcaCgaaccaggccacgaagatgt	12	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:42275398C>T	ENST00000342228.3	-	11	2251	c.1882G>A	c.(1882-1884)Gtg>Atg	p.V628M	SLC20A2_ENST00000520179.1_Missense_Mutation_p.V628M|SLC20A2_ENST00000520262.1_Missense_Mutation_p.V628M	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	628					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GGGACGGTCACGAACCAGGCC	0.592													79	64					0	0	1	0	0	T	42275398	C	T	42275398	3	4	21	1	0	0	0	0	1	0	0	0	14493	536	19	1	80	1	SLC20A2	8	42275398	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	252784	42275398	104088624	321	1742										
PRKDC	5591	broad.mit.edu	37	chr8	48701554	48701555	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttcatacattttttcaatgINSttttttttatttacaggggt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:48701554_48701555insT	ENST00000314191.2	-	77	10867_10868	c.10811_10812insA	c.(10810-10812)aatfs	p.N3604fs	PRKDC_ENST00000338368.3_Frame_Shift_Ins_p.N3604fs|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3605					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TTTTTTCAATGTTTTTTTTATT	0.401								Non-homologous end-joining					22	121	---	---	---	---						T	48701555	-	T	48701554	7	5	21	1	0	1	1	0	0	0	0	0	12572	1368	48	0	1615	0	PRKDC	8	48701554	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	6426156	48701554	97662468	322	1743										
PRKDC	5591	broad.mit.edu	37	chr8	48801143	48801143	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtttacaggcagacacaacaGcagccagcctgctcctgtcc	9	15	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:48801143G>A	ENST00000314191.2	-	35	4402	c.4346C>T	c.(4345-4347)gCt>gTt	p.A1449V	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.A1449V	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	1450					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGACACAACAGCAGCCAGCCT	0.448								Non-homologous end-joining					7	15					0	0	1	0	0	A	48801143	G	A	48801143	3	1	21	1	0	0	0	0	1	0	0	0	12572	971	34	3	8249	3	PRKDC	8	48801143	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	99589	48801143	97562879	323	1744										
PXDNL	137902	broad.mit.edu	37	chr8	52336136	52336136	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggagctatagacacctaccCgtgactgtaagaaacatgtt	9	9	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:52336136C>A	ENST00000356297.4	-	14	1894	c.1795_splice	c.e14+1	p.T598_splice	PXDNL_ENST00000543296.1_Splice_Site_p.T598_splice	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	598					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GACACCTACCCGTGACTGTAA	0.438													19	45					5.3912e-06	5.55592e-06	1	1	0	A	52336136	C	A	52336136	5	1	21	1	0	0	0	0	0	0	1	0	12899	666	23	5	2637	5	PXDNL	8	52336136	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3534993	52336136	94027886	324	1745										
RB1CC1	9821	broad.mit.edu	37	chr8	53586500	53586500	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	taacaaagagacattaaaaaAgggcagatcaccatctttag	7	7	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:53586500A>G	ENST00000025008.5	-	7	1430	c.907T>C	c.(907-909)Ttt>Ctt	p.F303L	RB1CC1_ENST00000435644.2_Missense_Mutation_p.F303L|RB1CC1_ENST00000539297.1_Missense_Mutation_p.F303L|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	303					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ACATTAAAAAAGGGCAGATCA	0.388													121	49					0	0	1	0	0	G	53586500	A	G	53586500	3	3	21	1	0	0	0	0	1	0	0	0	13150	72	3	4	3949	4	RB1CC1	8	53586500	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1250364	53586500	92777522	325	1746										
OPRK1	4986	broad.mit.edu	37	chr8	54163550	54163550	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcaggcaggcgctcggggcGcaggtagggcccggctcccc	19	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:54163550G>A	ENST00000265572.3	-	2	345	c.48C>T	c.(46-48)tgC>tgT	p.C16C	OPRK1_ENST00000520287.1_Silent_p.C16C	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	16					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CGCTCGGGGCGCAGGTAGGGC	0.741													17	33					0	0	1	0	0	A	54163550	G	A	54163550	2	1	21	1	0	0	0	0	0	0	0	1	10932	1079	38	1		1	OPRK1	8	54163550	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	577050	54163550	92200472	326	1747										
SOX17	64321	broad.mit.edu	37	chr8	55371765	55371766	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagcggctgaagcgggtggaINSgggcggcttcctgcacggcc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:55371765_55371766insG	ENST00000297316.4	+	2	659_660	c.455_456insG	c.(454-456)gggfs	p.G152fs		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	152					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			AAGCGGGTGGAGGGCGGCTTCC	0.743													21	7	---	---	---	---						G	55371766	-	G	55371765	7	5	21	1	0	1	1	0	0	0	0	0	15000	304	11	0	461	0	SOX17	8	55371765	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	1208215	55371765	90992257	327	1748										
LYN	4067	broad.mit.edu	37	chr8	56863330	56863330	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctttccttattagagaaagTgaaacattaaaaggtaggaa	9	4	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:56863330T>C	ENST00000520220.2	+	6	685	c.411T>C	c.(409-411)agT>agC	p.S137S	LYN_ENST00000519728.1_Silent_p.S158S	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	158	SH2.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TTAGAGAAAGTGAAACATTAA	0.373													25	122					0	0	1	0	0	C	56863330	T	C	56863330	2	2	21	1	0	0	0	0	0	0	0	1	9152	1693	59	4		4	LYN	8	56863330	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1491565	56863330	89500692	328	1749										
CHD7	55636	broad.mit.edu	37	chr8	61778453	61778454	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagagctagactcacttgatINSgggggggatgaaatagaaaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:61778453_61778454insG	ENST00000423902.2	+	38	9434_9435	c.8955_8956insG	c.(8953-8958)gaggggfs	p.EG2985fs	CHD7_ENST00000524602.1_Frame_Shift_Ins_p.EG936fs	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2985					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACTCACTTGATGGGGGGGATGA	0.446													18	16	---	---	---	---						G	61778454	-	G	61778453	7	5	21	1	0	1	1	0	0	0	0	0	3352	1461	51	0	9101	0	CHD7	8	61778453	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	4915123	61778453	84585569	329	1750										
PREX2	80243	broad.mit.edu	37	chr8	69009342	69009342	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caatgtccacctggaatatgGtgtcgtgtatgagtacgaca	11	8	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:69009342G>A	ENST00000288368.4	+	22	2736	c.2459G>A	c.(2458-2460)gGt>gAt	p.G820D	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	820					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.G820A(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTGGAATATGGTGTCGTGTAT	0.453													121	44					0	0	1	0	0	A	69009342	G	A	69009342	3	1	21	1	0	0	0	0	1	0	0	0	12528	1261	44	3	2545	3	PREX2	8	69009342	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7230889	69009342	77354680	330	1751										
NCOA2	10499	broad.mit.edu	37	chr8	71056964	71056964	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggtatcactgagtagggacTactgtttctgattggtggga							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:71056964delT	ENST00000452400.2	-	13	2906	c.2725delA	c.(2725-2727)gtfs	p.S909fs	NCOA2_ENST00000267974.4_Intron	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	909					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GAGTAGGGACTACTGTTTCTG	0.468			T	"RUNXBP2, HEY1"	"AML, Chondrosarcoma"								43	102	---	---	---	---						-	71056964	T	-	71056964	7	5	21	1	0	1	0	1	0	0	0	0	10275	1522	53	0	1713	0	NCOA2	8	71056964	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2047622	71056964	75307058	331	1752										
ZNF704	619279	broad.mit.edu	37	chr8	81553673	81553673	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgtctcggttctccatcccGtacaccttccgacacttttt	5	15	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:81553673G>A	ENST00000327835.3	-	9	1398	c.1167C>T	c.(1165-1167)taC>taT	p.Y389Y		NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	389						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TCTCCATCCCGTACACCTTCC	0.572													12	64					0	0	1	0	0	A	81553673	G	A	81553673	2	1	21	1	0	0	0	0	0	0	0	1	18162	1140	40	1		1	ZNF704	8	81553673	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	10496709	81553673	64810349	332	1753										
ATP6V0D2	245972	broad.mit.edu	37	chr8	87165043	87165043	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttactttttttctttcctcAggtacaaatgaatgtgctgg	8	7	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:87165043A>G	ENST00000285393.3	+	8	1033		c.e8-1		CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						TTCTTTCCTCAGGTACAAATG	0.358													106	68					0	0	1	0	0	G	87165043	A	G	87165043	5	3	21	1	0	0	0	0	0	0	1	0	1172	202	7	4	920	4	ATP6V0D2	8	87165043	Splice_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	5611370	87165043	59198979	333	1754										
DCAF4L2	138009	broad.mit.edu	37	chr8	88885771	88885771	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcaagtcccacgaagcacagCagaaggtgggaatccaagtg	13	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:88885771C>T	ENST00000319675.3	-	1	525	c.429G>A	c.(427-429)ctG>ctA	p.L143L		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	143								p.L143L(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CGAAGCACAGCAGAAGGTGGG	0.562													110	55					0	0	1	0	0	T	88885771	C	T	88885771	2	4	21	1	0	0	0	0	0	0	0	1	4296	697	25	3		3	DCAF4L2	8	88885771	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1720728	88885771	57478251	334	1755										
GEM	2669	broad.mit.edu	37	chr8	95264399	95264399	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgtgattgagtagacaatcAggtatgcgtccccgacctgc	11	11	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:95264399A>G	ENST00000297596.2	-	4	725	c.461T>C	c.(460-462)cTg>cCg	p.L154P	GEM_ENST00000396194.2_Missense_Mutation_p.L154P	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	154					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTAGACAATCAGGTATGCGTC	0.517													25	137					0	0	1	0	0	G	95264399	A	G	95264399	3	3	21	1	0	0	0	0	1	0	0	0	6370	188	7	4	437	4	GEM	8	95264399	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	6378628	95264399	51099623	335	1756										
RIMS2	9699	broad.mit.edu	37	chr8	104898136	104898136	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accatagtcctcctacccccAggaggagtccactacccata	6	17	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:104898136A>G	ENST00000507740.1	+	2	969	c.733A>G	c.(733-735)Agg>Ggg	p.R245G	RIMS2_ENST00000436393.2_Missense_Mutation_p.R215G|RIMS2_ENST00000262231.10_Missense_Mutation_p.R245G|RIMS2_ENST00000406091.3_Missense_Mutation_p.R437G	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	468					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCCTACCCCCAGGAGGAGTCC	0.468										HNSCC(12;0.0054)			12	110					0	0	1	0	0	G	104898136	A	G	104898136	3	3	21	1	0	0	0	0	1	0	0	0	13419	179	7	4	1449	4	RIMS2	8	104898136	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	9633737	104898136	41465886	336	1757										
ZFPM2	23414	broad.mit.edu	37	chr8	106815052	106815052	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agctacgaaagaagcataatAaaatgtgagaaaaatgggaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:106815052delA	ENST00000407775.2	+	8	2992	c.2742delA	c.(2740-2742)atfs	p.I914fs	ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000520492.1_Frame_Shift_Del_p.I782fs|ZFPM2_ENST00000517361.1_Frame_Shift_Del_p.I782fs|ZFPM2_ENST00000378472.4_Frame_Shift_Del_p.I645fs|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	914					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAAGCATAATAAAATGTGAGA	0.453													42	20	---	---	---	---						-	106815052	A	-	106815052	7	5	21	1	0	1	0	1	0	0	0	0	17715	352	13	0	2772	0	ZFPM2	8	106815052	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1916916	106815052	39548970	337	1758										
SYBU	55638	broad.mit.edu	37	chr8	110587865	110587865	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccctgtcagccccttcccccGtgacctgctcttccagagat	7	19	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:110587865G>A	ENST00000399066.3	-	6	1980	c.1253C>T	c.(1252-1254)aCg>aTg	p.T418M	SYBU_ENST00000446070.2_Missense_Mutation_p.T420M|SYBU_ENST00000433638.1_Missense_Mutation_p.T421M|SYBU_ENST00000529175.1_Missense_Mutation_p.T215M|SYBU_ENST00000408908.2_Missense_Mutation_p.T421M|SYBU_ENST00000440310.1_Missense_Mutation_p.T421M|SYBU_ENST00000408889.3_Missense_Mutation_p.T302M|SYBU_ENST00000422135.1_Missense_Mutation_p.T421M|SYBU_ENST00000533895.1_Missense_Mutation_p.T420M|SYBU_ENST00000528647.1_Missense_Mutation_p.T420M|SYBU_ENST00000419099.1_Missense_Mutation_p.T420M|SYBU_ENST00000533171.1_Missense_Mutation_p.T421M|SYBU_ENST00000276646.9_Missense_Mutation_p.T421M|SYBU_ENST00000528331.1_Missense_Mutation_p.T302M|SYBU_ENST00000424158.2_Missense_Mutation_p.T426M|SYBU_ENST00000532779.1_Missense_Mutation_p.T353M|SYBU_ENST00000529690.1_Missense_Mutation_p.T291M|SYBU_ENST00000533065.1_Missense_Mutation_p.T302M	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	421						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						CCCTTCCCCCGTGACCTGCTC	0.522													22	113					0	0	1	0	0	A	110587865	G	A	110587865	3	1	21	1	0	0	0	0	1	0	0	0	15482	1145	40	1	733	1	SYBU	8	110587865	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3772813	110587865	35776157	338	1759										
DSCC1	79075	broad.mit.edu	37	chr8	120850597	120850597	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcaggtaaatcatctactttCagcaaaaatatgatttctgg	6	7	5	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:120850597C>T	ENST00000313655.4	-	8	1189	c.975G>A	c.(973-975)ctG>ctA	p.L325L		NM_024094.2	NP_076999.2	Q9BVC3	DCC1_HUMAN	DNA replication and sister chromatid cohesion 1	325					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|pancreas(1)	9	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATCTACTTTCAGCAAAAATA	0.368													45	150					0	0	1	0	0	T	120850597	C	T	120850597	2	4	21	1	0	0	0	0	0	0	0	1	4796	813	29	3		3	DSCC1	8	120850597	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	10262732	120850597	25513425	339	1760										
SNTB1	6641	broad.mit.edu	37	chr8	121561041	121561041	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagttcagcagaattgtggcAaccctgtactatgctccttg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:121561041delA	ENST00000395601.3	-	6	1708	c.1294delT	c.(1294-1296)gcfs	p.C432fs	SNTB1_ENST00000517992.1_Frame_Shift_Del_p.C432fs	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	432	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GAATTGTGGCAACCCTGTACT	0.507													8	112	---	---	---	---						-	121561041	A	-	121561041	7	5	21	1	0	1	0	1	0	0	0	0	14925	130	5	0	334	0	SNTB1	8	121561041	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	710444	121561041	24802981	340	1761										
ZHX1	11244	broad.mit.edu	37	chr8	124266662	124266662	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtgtcactaaaccatttttTaatctctcctttcgtcaggc	5	11	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:124266662T>A	ENST00000395571.3	-	3	2142	c.1525A>T	c.(1525-1527)Aaa>Taa	p.K509*	ZHX1_ENST00000297857.2_Nonsense_Mutation_p.K509*|ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000522655.1_Nonsense_Mutation_p.K509*	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	509	Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AACCATTTTTTAATCTCTCCT	0.348													80	215					0	0	1	0	0	A	124266662	T	A	124266662	4	1	21	1	0	0	0	0	0	1	0	0	17732	1763	61	4	1100	4	ZHX1	8	124266662	Nonsense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2705621	124266662	22097360	341	1762										
ATAD2	29028	broad.mit.edu	37	chr8	124382144	124382144	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctcttcttctccatcttctTcatcttcatcatcttcatca	0	15	12	0	rs150184958		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:124382144T>C	ENST00000287394.5	-	7	955	c.848A>G	c.(847-849)gAa>gGa	p.E283G	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	283	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			tccatcttcttcatcttcatc	0.368													26	17					0	0	1	0	0	C	124382144	T	C	124382144	3	2	21	1	0	0	0	0	1	0	0	0	1070	1783	62	4	3412	4	ATAD2	8	124382144	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	115482	124382144	21981878	342	1763										
ATAD2	29028	broad.mit.edu	37	chr8	124382167	124382167	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcttcatcatcttcatcatcAtcatcatcatcatcatcgtc	1	14	12	0	rs149531312	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:124382167A>T	ENST00000287394.5	-	7	932	c.825T>A	c.(823-825)gaT>gaA	p.D275E	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	275	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			cttcatcatcatcatcatcat	0.378													17	18					0	0	1	0	0	T	124382167	A	T	124382167	3	4	21	1	0	0	0	0	1	0	0	0	1070	214	8	4	3435	4	ATAD2	8	124382167	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	23	124382167	21981855	343	1764										
FER1L6	654463	broad.mit.edu	37	chr8	125072512	125072512	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgccaacattcggccggtgcTgagcaaataccgagtggagg	14	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:125072512T>C	ENST00000522917.1	+	23	3172	c.2966T>C	c.(2965-2967)cTg>cCg	p.L989P	FER1L6-AS2_ENST00000601180.1_RNA|FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.L989P	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	989						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CGGCCGGTGCTGAGCAAATAC	0.587													118	54					0	0	1	0	0	C	125072512	T	C	125072512	3	2	21	1	0	0	0	0	1	0	0	0	5847	1580	55	4	3052	4	FER1L6	8	125072512	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	690345	125072512	21291510	344	1765										
SQLE	6713	broad.mit.edu	37	chr8	126011893	126011893	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggcttcttctgggccaaatCcccccctgaatcagaaaata							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:126011893delC	ENST00000265896.5	+	1	1146	c.248delC	c.(247-249)tcfs	p.S83fs	SQLE_ENST00000523430.1_Intron	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	83					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	TGGGCCAAATCCCCCCCTGAA	0.547													38	31	---	---	---	---						-	126011893	C	-	126011893	7	5	21	1	0	1	0	1	0	0	0	0	15183	855	30	0	250	0	SQLE	8	126011893	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	939381	126011893	20352129	345	1766										
MYC	4609	broad.mit.edu	37	chr8	128750639	128750639	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagcgagctgcagcccccggCgcccagcgaggatatctgga	15	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:128750639C>T	ENST00000377970.2	+	2	686	c.176C>T	c.(175-177)gCg>gTg	p.A59V	MYC_ENST00000259523.6_Missense_Mutation_p.A44V|MYC_ENST00000524013.1_Missense_Mutation_p.A58V	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	44			P -> A (in a Burkitt lymphoma sample).		branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		CAGCCCCCGGCGCCCAGCGAG	0.637	A59V(RAJI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|A59V(TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	3	"A, T"	"IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"	"Burkitt lymphoma,  amplified in other cancers, B-CLL"						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	88	35					0	0	1	0	0	T	128750639	C	T	128750639	3	4	21	1	0	0	0	0	1	0	0	0	10063	768	27	1	182	1	MYC	8	128750639	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2738746	128750639	17613383	346	1767										
TG	7038	broad.mit.edu	37	chr8	133910007	133910007	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgcgtttggaagttgggagCctgtgcagtgccacgctggg	17	8	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:133910007C>T	ENST00000220616.4	+	12	3155	c.3115C>T	c.(3115-3117)Cct>Tct	p.P1039S	TG_ENST00000377869.1_Missense_Mutation_p.P1039S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1039	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AAGTTGGGAGCCTGTGCAGTG	0.597													36	111					0	0	1	0	0	T	133910007	C	T	133910007	3	4	21	1	0	0	0	0	1	0	0	0	15872	739	26	3	3161	3	TG	8	133910007	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5159368	133910007	12454015	347	1768										
TG	7038	broad.mit.edu	37	chr8	133923762	133923762	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcccagtggcttctcttccTgacttacatgacattggtat	7	11	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:133923762T>C	ENST00000220616.4	+	19	4183	c.4143T>C	c.(4141-4143)ccT>ccC	p.P1381P	TG_ENST00000377869.1_Silent_p.P1381P	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1381					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTTCTCTTCCTGACTTACATG	0.473													57	148					0	0	1	0	0	C	133923762	T	C	133923762	2	2	21	1	0	0	0	0	0	0	0	1	15872	1567	55	4		4	TG	8	133923762	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	13755	133923762	12440260	348	1769										
FAM135B	51059	broad.mit.edu	37	chr8	139189663	139189663	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcctcagaaaaccttcggaCctgcagaataaaacaatgta	8	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:139189663C>T	ENST00000395297.1	-	11	1200	c.1029_splice	c.e11-1	p.V344_splice		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	344										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AACCTTCGGACCTGCAGAATA	0.373										HNSCC(54;0.14)			13	26					0	0	1	0	0	T	139189663	C	T	139189663	5	4	21	1	0	0	0	0	0	0	1	0	5480	521	18	3	3230	3	FAM135B	8	139189663	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5265901	139189663	7174359	349	1770										
DENND3	22898	broad.mit.edu	37	chr8	142148219	142148219	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctatggcgtggtggcccagTactaccggcccctgcatgta	12	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:142148219T>C	ENST00000519811.1	+	3	554	c.484T>C	c.(484-486)Tac>Cac	p.Y162H	DENND3_ENST00000518347.1_Missense_Mutation_p.Y162H|DENND3_ENST00000262585.2_Missense_Mutation_p.Y82H|DENND3_ENST00000424248.1_Missense_Mutation_p.Y82H			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	82	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTGGCCCAGTACTACCGGCC	0.512													4	30					0	0	1	0	0	C	142148219	T	C	142148219	3	2	21	1	0	0	0	0	1	0	0	0	4460	1638	57	4	250	4	DENND3	8	142148219	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2958556	142148219	4215803	350	1771										
MAPK15	225689	broad.mit.edu	37	chr8	144800992	144800992	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agggcggcctgctgcaggacGtccacgtgcgctccatcttc	13	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144800992G>A	ENST00000338033.4	+	5	453	c.334G>A	c.(334-336)Gtc>Atc	p.V112I	RP11-429J17.5_ENST00000527908.1_RNA|MAPK15_ENST00000395108.2_Missense_Mutation_p.V112I|MAPK15_ENST00000395107.4_Missense_Mutation_p.V129I	NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	112	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCTGCAGGACGTCCACGTGCG	0.692													14	33					0	0	1	0	0	A	144800992	G	A	144800992	3	1	21	1	0	0	0	0	1	0	0	0	9326	1145	40	1	352	1	MAPK15	8	144800992	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2652773	144800992	1563030	351	1772										
EPPK1	83481	broad.mit.edu	37	chr8	144945055	144945055	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggaggtacaggcccgtctcGgggtcacgcacacagcgctc	14	14	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144945055G>A	ENST00000525985.1	-	2	2438	c.2367C>T	c.(2365-2367)ccC>ccT	p.P789P				P58107	EPIPL_HUMAN	epiplakin 1	789						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCCCGTCTCGGGGTCACGCA	0.627													48	142					0	0	1	0	0	A	144945055	G	A	144945055	2	1	21	1	0	0	0	0	0	0	0	1	5218	1103	39	1		1	EPPK1	8	144945055	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	144063	144945055	1418967	352	1773										
EPPK1	83481	broad.mit.edu	37	chr8	144947314	144947314	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgctcctggcctggggcctGgggggcgtgccggctcccag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144947314delG	ENST00000525985.1	-	2	179	c.108delC	c.(106-108)ccfs	p.P36fs				P58107	EPIPL_HUMAN	epiplakin 1	36						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTGGGGCCTGGGGGGCGTGC	0.697													38	123	---	---	---	---						-	144947314	G	-	144947314	7	5	21	1	0	1	0	1	0	0	0	0	5218	1335	47	0	7158	0	EPPK1	8	144947314	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2259	144947314	1416708	353	1774										
PLEC	5339	broad.mit.edu	37	chr8	144997961	144997961	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttctcttccgcctgcagccGcttctgggcggcctcctggg	12	17	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144997961G>A	ENST00000322810.4	-	31	6716	c.6547C>T	c.(6547-6549)Cgg>Tgg	p.R2183W	PLEC_ENST00000356346.3_Missense_Mutation_p.R2032W|PLEC_ENST00000354589.3_Missense_Mutation_p.R2046W|PLEC_ENST00000398774.2_Missense_Mutation_p.R2014W|PLEC_ENST00000436759.2_Missense_Mutation_p.R2073W|PLEC_ENST00000527096.1_Missense_Mutation_p.R2069W|PLEC_ENST00000357649.2_Missense_Mutation_p.R2050W|PLEC_ENST00000345136.3_Missense_Mutation_p.R2046W|PLEC_ENST00000354958.2_Missense_Mutation_p.R2024W	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2183	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCTGCAGCCGCTTCTGGGCG	0.701													5	19					0	0	1	0	0	A	144997961	G	A	144997961	3	1	21	1	0	0	0	0	1	0	0	0	12099	1086	38	1	7515	1	PLEC	8	144997961	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	50647	144997961	1366061	354	1775										
KIAA1432	57589	broad.mit.edu	37	chr9	5774180	5774180	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atggtcagccggaaagaggaGgacacagcccaagcagagga	15	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:5774180G>T	ENST00000414202.2	+	26	4397	c.4206G>T	c.(4204-4206)gaG>gaT	p.E1402D	KIAA1432_ENST00000449720.2_Missense_Mutation_p.E1286D|KIAA1432_ENST00000418622.3_Missense_Mutation_p.E1323D	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1402						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GGAAAGAGGAGGACACAGCCC	0.547													32	50					1.99505e-19	2.19531e-19	1	1	0	T	5774180	G	T	5774180	3	4	21	1	0	0	0	0	1	0	0	0	8274	991	35	5	4141	5	KIAA1432	9	5774180	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08		5774180	135439251	355	1776										
PTPRD	5789	broad.mit.edu	37	chr9	8521547	8521547	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcttggtgggacacggcgaaCtggaacaaaacacaagggaa	13	8	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:8521547C>T	ENST00000381196.4	-	17	1235		c.e17-1		PTPRD_ENST00000486161.1_Splice_Site|PTPRD_ENST00000356435.5_Splice_Site|PTPRD_ENST00000355233.5_Splice_Site|PTPRD_ENST00000397606.3_Splice_Site|PTPRD_ENST00000397611.3_Splice_Site|PTPRD_ENST00000397617.3_Splice_Site|PTPRD_ENST00000540109.1_Splice_Site|PTPRD_ENST00000360074.4_Splice_Site|PTPRD_ENST00000537002.1_Splice_Site|PTPRD_ENST00000358503.5_Splice_Site	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACACGGCGAACTGGAACAAAA	0.438										TSP Lung(15;0.13)			34	45					0	0	1	0	0	T	8521547	C	T	8521547	5	4	21	1	0	0	0	0	0	0	1	0	12850	579	20	3	5223	3	PTPRD	9	8521547	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2747367	8521547	132691884	356	1777										
TYRP1	7306	broad.mit.edu	37	chr9	12702411	12702414	+	Frame_Shift_Del	DEL	ACAA	ACAA	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcctttttattccaactctAcaaacagtttccgaaacaca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:12702411_12702414delACAA	ENST00000388918.5	+	5	1183_1186	c.1054_1057delACAA	c.(1054-1059)acfs	p.TN352fs	TYRP1_ENST00000381137.2_Frame_Shift_Del_p.TN62fs|TYRP1_ENST00000381136.2_Frame_Shift_Del_p.TN62fs|RP11-3L8.3_ENST00000417638.1_RNA	NM_000550.2	NP_000541.1	P17643	TYRP1_HUMAN	tyrosinase-related protein 1	352					melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity	p.N353fs*31(2)		NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|stomach(1)	22		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		TTCCAACTCTACAAACAGTTTCCG	0.387									Oculocutaneous Albinism				14	24	---	---	---	---						-	12702414	ACAA	-	12702411	7	5	21	1	0	1	0	1	0	0	0	0	16877	391	14	0	1068	0	TYRP1	9	12702411	Frame_Shift_Del	DEL	ACAA	TCGA-N7-A4Y0-01A-12D-A28R-08	4180864	12702411	128511020	357	1778										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18829843	18829843	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccctctgccttctcacagatCccccccaagtccccacacag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:18829843delC	ENST00000380548.4	+	23	4456	c.4117delC	c.(4117-4119)ccfs	p.P1374fs	ADAMTSL1_ENST00000380545.5_Frame_Shift_Del_p.P75fs	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1374						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TCTCACAGATCCCCCCCAAGT	0.567													36	51	---	---	---	---						-	18829843	C	-	18829843	7	5	21	1	0	1	0	1	0	0	0	0	273	855	30	0	4211	0	ADAMTSL1	9	18829843	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6127432	18829843	122383588	358	1779										
IFNW1	3467	broad.mit.edu	37	chr9	21141170	21141170	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcagggctgctaattgcccCagcagattctccttctccca	8	15	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:21141170C>T	ENST00000380229.2	-	1	974	c.400G>A	c.(400-402)Ggg>Agg	p.G134R		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	134					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTAATTGCCCCAGCAGATTCT	0.527													33	44					0	0	1	0	0	T	21141170	C	T	21141170	3	4	21	1	0	0	0	0	1	0	0	0	7595	594	21	3	191	3	IFNW1	9	21141170	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2311327	21141170	120072261	359	1780										
IFNW1	3467	broad.mit.edu	37	chr9	21141286	21141286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgttccaggcagcagaggagCgctctgtgtggaagaggctg	17	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:21141286C>T	ENST00000380229.2	-	1	858	c.284G>A	c.(283-285)cGc>cAc	p.R95H		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	95			R -> S (in dbSNP:rs2230055).		cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGCAGAGGAGCGCTCTGTGTG	0.557													42	64					0	0	1	0	0	T	21141286	C	T	21141286	3	4	21	1	0	0	0	0	1	0	0	0	7595	768	27	1	307	1	IFNW1	9	21141286	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	116	21141286	120072145	360	1781										
SMU1	55234	broad.mit.edu	37	chr9	33053232	33053232	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acggtaatatctgtccctgcGgtgctgcccagggatttaaa	11	10	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:33053232G>A	ENST00000397149.3	-	10	1229	c.1179C>T	c.(1177-1179)acC>acT	p.T393T	SMU1_ENST00000536631.1_Silent_p.T232T	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	393						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		CTGTCCCTGCGGTGCTGCCCA	0.398													38	47					0	0	1	0	0	A	33053232	G	A	33053232	2	1	21	1	0	0	0	0	0	0	0	1	14870	1103	39	1		1	SMU1	9	33053232	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	11911946	33053232	108160199	361	1782										
NFX1	0	broad.mit.edu	37	chr9	33294897	33294897	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcccaggggagcaaaacccAaaaaagcaacacagtttgta							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:33294897delA	ENST00000379540.3	+	2	567	c.505delA	c.(505-507)aafs	p.K170fs	NFX1_ENST00000318524.6_Frame_Shift_Del_p.K170fs|NFX1_ENST00000379521.4_Frame_Shift_Del_p.K170fs	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	170					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		AGCAAAACCCAAAAAAGCAAC	0.483													31	64	---	---	---	---						-	33294897	A	-	33294897	7	5	21	1	0	1	0	1	0	0	0	0	10433	131	5	0	511	0	NFX1	9	33294897	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	241665	33294897	107918534	362	1783										
RUSC2	9853	broad.mit.edu	37	chr9	35555086	35555086	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgagagccgaccagtccttCgctacagcaaggaacagagg	12	13	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:35555086C>T	ENST00000455600.1	+	3	2613	c.2044C>T	c.(2044-2046)Cgc>Tgc	p.R682C		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	682						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACCAGTCCTTCGCTACAGCAA	0.577													71	91					0	0	1	0	0	T	35555086	C	T	35555086	3	4	21	1	0	0	0	0	1	0	0	0	13802	884	31	1	2050	1	RUSC2	9	35555086	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2260189	35555086	105658345	363	1784										
FRMPD1	22844	broad.mit.edu	37	chr9	37740148	37740148	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtactcgaacctctctctgaCaggcgcctggtgaaactggc	11	13	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:37740148C>T	ENST00000539465.1	+	15	2216	c.1623C>T	c.(1621-1623)gaC>gaT	p.D541D	FRMPD1_ENST00000377765.3_Silent_p.D541D|FRMPD1_ENST00000536622.1_Silent_p.D363D|FRMPD1_ENST00000541302.1_Silent_p.D410D|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	541						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTCTCTCTGACAGGCGCCTGG	0.587													49	88					0	0	1	0	0	T	37740148	C	T	37740148	2	4	21	1	0	0	0	0	0	0	0	1	6091	477	17	3		3	FRMPD1	9	37740148	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2185062	37740148	103473283	364	1785										
ALDH1B1	219	broad.mit.edu	37	chr9	38395909	38395909	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtcagcaagaagaccttccCgacggtcaaccctaccaccg	8	16	2	2	rs144062423	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:38395909C>T	ENST00000377698.3	+	2	317	c.164C>T	c.(163-165)cCg>cTg	p.P55L		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	55					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	AAGACCTTCCCGACGGTCAAC	0.597													37	63					0	0	1	0	0	T	38395909	C	T	38395909	3	4	21	1	0	0	0	0	1	0	0	0	490	652	23	1	166	1	ALDH1B1	9	38395909	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	655761	38395909	102817522	365	1786										
PGM5	5239	broad.mit.edu	37	chr9	70993145	70993145	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgattattggacagaatggcAtcttgtcgacacctgcggtc	11	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:70993145A>G	ENST00000396396.1	+	2	521	c.292A>G	c.(292-294)Atc>Gtc	p.I98V	PGM5_ENST00000604870.2_3'UTR|PGM5_ENST00000396392.1_Missense_Mutation_p.I98V	NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity	p.I98V(3)		endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						ACAGAATGGCATCTTGTCGAC	0.478													5	70					0	0	1	0	0	G	70993145	A	G	70993145	3	3	21	1	0	0	0	0	1	0	0	0	11848	217	8	4	298	4	PGM5	9	70993145	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	32597236	70993145	70220286	366	1787										
PIP5K1B	8395	broad.mit.edu	37	chr9	71491650	71491650	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gactttagatttaagacataCgctccattagcattccgata	6	9	0	2	rs143726902	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:71491650C>T	ENST00000265382.3	+	6	563	c.258C>T	c.(256-258)taC>taT	p.Y86Y	PIP5K1B_ENST00000541509.1_Silent_p.Y86Y	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	86	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		TTAAGACATACGCTCCATTAG	0.373													28	36					0	0	1	0	0	T	71491650	C	T	71491650	2	4	21	1	0	0	0	0	0	0	0	1	11987	547	19	1		1	PIP5K1B	9	71491650	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	498505	71491650	69721781	367	1788										
ALDH1A1	216	broad.mit.edu	37	chr9	75543858	75543858	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagcccaacctgcacagtagCgcaatgttttgatgcagcct	9	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:75543858C>T	ENST00000297785.3	-	4	446	c.392G>A	c.(391-393)cGc>cAc	p.R131H	ALDH1A1_ENST00000482210.1_5'UTR|ALDH1A1_ENST00000376939.1_Missense_Mutation_p.R131H	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	131					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGCACAGTAGCGCAATGTTTT	0.428													48	90					0	0	1	0	0	T	75543858	C	T	75543858	3	4	21	1	0	0	0	0	1	0	0	0	487	768	27	1	1153	1	ALDH1A1	9	75543858	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4052208	75543858	65669573	368	1789										
ALDH1A1	216	broad.mit.edu	37	chr9	75545849	75545849	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccaacttgtataatagtcgCcccctctcggaagcatccat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:75545849delC	ENST00000297785.3	-	3	312	c.258delG	c.(256-258)ggfs	p.G86fs	ALDH1A1_ENST00000482210.1_5'UTR|ALDH1A1_ENST00000376939.1_Frame_Shift_Del_p.G86fs	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	86					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	ATAATAGTCGCCCCCTCTCGG	0.498													58	88	---	---	---	---						-	75545849	C	-	75545849	7	5	21	1	0	1	0	1	0	0	0	0	487	726	26	0	1291	0	ALDH1A1	9	75545849	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1991	75545849	65667582	369	1790										
GNAQ	2776	broad.mit.edu	37	chr9	80343579	80343579	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagccttgctttcctccattCggttctggaaaaaaaaaaaa	7	9	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:80343579C>T	ENST00000286548.4	-	6	962	c.740G>A	c.(739-741)cGa>cAa	p.R247Q	GNAQ_ENST00000397476.3_Missense_Mutation_p.R45Q	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	247					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						TTCCTCCATTCGGTTCTGGAA	0.333			Mis		uveal melanoma								53	85					0	0	1	0	0	T	80343579	C	T	80343579	3	4	21	1	0	0	0	0	1	0	0	0	6550	884	31	1	347	1	GNAQ	9	80343579	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4797730	80343579	60869852	370	1791										
SLC28A3	64078	broad.mit.edu	37	chr9	86900965	86900965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagattcacagcgatgttggCcaccagggagatggaggagg	16	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:86900965C>T	ENST00000376238.4	-	13	1391	c.1342G>A	c.(1342-1344)Gcc>Acc	p.A448T	SLC28A3_ENST00000537648.1_Missense_Mutation_p.A379T|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	448					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GCGATGTTGGCCACCAGGGAG	0.473													16	19					0	0	1	0	0	T	86900965	C	T	86900965	3	4	21	1	0	0	0	0	1	0	0	0	14587	739	26	3	757	3	SLC28A3	9	86900965	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6557386	86900965	54312466	371	1792										
SPIN1	10927	broad.mit.edu	37	chr9	91083304	91083304	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagcgacatctcgaatcagcGatgcacacttggcagacaca	9	13	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:91083304G>A	ENST00000375859.3	+	5	651	c.373G>A	c.(373-375)Gat>Aat	p.D125N	SPIN1_ENST00000469017.2_3'UTR|SPIN1_ENST00000541629.1_Missense_Mutation_p.D125N	NM_006717.2	NP_006708.2	Q9Y657	SPIN1_HUMAN	spindlin 1	125					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						TCGAATCAGCGATGCACACTT	0.413													23	31					0	0	1	0	0	A	91083304	G	A	91083304	3	1	21	1	0	0	0	0	1	0	0	0	15107	1058	37	1	387	1	SPIN1	9	91083304	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4182339	91083304	50130127	372	1793										
SECISBP2	79048	broad.mit.edu	37	chr9	91964840	91964840	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agatccacagccgcagattcAgggagtgagtgagcccctgc	13	12	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:91964840A>G	ENST00000375807.3	+	13	1959	c.1888A>G	c.(1888-1890)Agg>Ggg	p.R630G	SECISBP2_ENST00000339901.4_Missense_Mutation_p.R557G|SECISBP2_ENST00000534113.2_Missense_Mutation_p.R562G	NM_024077.3	NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	630					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						CCGCAGATTCAGGGAGTGAGT	0.567													30	38					0	0	1	0	0	G	91964840	A	G	91964840	3	3	21	1	0	0	0	0	1	0	0	0	14059	179	7	4	1938	4	SECISBP2	9	91964840	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	881536	91964840	49248591	373	1794										
ROR2	4920	broad.mit.edu	37	chr9	94486999	94486999	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gatctgtgccacaaggtgcaCgaagtcggggggctccaggg	17	10	1	0	rs146067291		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:94486999C>T	ENST00000375708.3	-	9	1975	c.1777G>A	c.(1777-1779)Gtg>Atg	p.V593M	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.V453M	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	593	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ACAAGGTGCACGAAGTCGGGG	0.632													20	29					0	0	1	0	0	T	94486999	C	T	94486999	3	4	21	1	0	0	0	0	1	0	0	0	13578	536	19	1	1058	1	ROR2	9	94486999	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2522159	94486999	46726432	374	1795										
PTCH1	5727	broad.mit.edu	37	chr9	98238411	98238411	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtgagggccacgctggctcCtgtgcgcttcaggcactccc	13	16	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:98238411C>A	ENST00000430669.2	-	12	2020	c.1435G>T	c.(1435-1437)Gga>Tga	p.G479*	PTCH1_ENST00000437951.1_Nonsense_Mutation_p.G479*|PTCH1_ENST00000375274.2_Nonsense_Mutation_p.G544*|PTCH1_ENST00000418258.1_Nonsense_Mutation_p.G394*|PTCH1_ENST00000331920.6_Nonsense_Mutation_p.G545*|PTCH1_ENST00000421141.1_Nonsense_Mutation_p.G394*|PTCH1_ENST00000429896.2_Nonsense_Mutation_p.G394*			Q13635	PTC1_HUMAN	patched 1	545	SSD.				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				ACGCTGGCTCCTGTGCGCTTC	0.592													13	11					1.5842e-08	1.66388e-08	1	1	0	A	98238411	C	A	98238411	4	1	21	1	0	0	0	0	0	1	0	0	12778	690	24	5	2758	5	PTCH1	9	98238411	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3751412	98238411	42975020	375	1796										
TSTD2	158427	broad.mit.edu	37	chr9	100367047	100367047	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtaggacagagcatagcgtTcatcaaaaacaaacaacttc	7	9	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:100367047T>C	ENST00000341170.4	-	9	1596	c.1214A>G	c.(1213-1215)gAa>gGa	p.E405G	TSTD2_ENST00000375172.2_Missense_Mutation_p.E179G|TSTD2_ENST00000354801.2_Missense_Mutation_p.E145G|TSTD2_ENST00000375165.1_Missense_Mutation_p.E145G	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	405										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						AGCATAGCGTTCATCAAAAAC	0.468													49	66					0	0	1	0	0	C	100367047	T	C	100367047	3	2	21	1	0	0	0	0	1	0	0	0	16736	1783	62	4	344	4	TSTD2	9	100367047	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2128636	100367047	40846384	376	1797										
TEX10	54881	broad.mit.edu	37	chr9	103108398	103108398	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttagagagtttccacagaaGggaaataatattaagaactt	8	4	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:103108398G>T	ENST00000374902.4	-	4	1269	c.1093C>A	c.(1093-1095)Ctt>Att	p.L365I	TEX10_ENST00000535814.1_Missense_Mutation_p.L368I|TEX10_ENST00000537512.1_Missense_Mutation_p.L300I	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	365						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TTCCACAGAAGGGAAATAATA	0.373													9	39					1.76689e-08	1.85133e-08	1	1	0	T	103108398	G	T	103108398	3	4	21	1	0	0	0	0	1	0	0	0	15830	1000	35	5	1744	5	TEX10	9	103108398	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2741351	103108398	38105033	377	1798										
C9orf84	158401	broad.mit.edu	37	chr9	114543240	114543240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aatcctccacaaagaaacttGctttccattggtccaagact	5	12	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:114543240G>A	ENST00000374287.3	-	4	295	c.35C>T	c.(34-36)gCa>gTa	p.A12V	C9orf84_ENST00000318737.4_Missense_Mutation_p.A12V|C9orf84_ENST00000374283.5_Missense_Mutation_p.A76V			Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	12										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AAAGAAACTTGCTTTCCATTG	0.353													31	37					0	0	1	0	0	A	114543240	G	A	114543240	3	1	21	1	0	0	0	0	1	0	0	0	2518	1319	46	3	4536	3	C9orf84	9	114543240	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	11434842	114543240	26670191	378	1799										
UGCG	7357	broad.mit.edu	37	chr9	114695179	114695180	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgaatccatgacaatatacaINStttttttgtctgcattatgg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:114695179_114695180insT	ENST00000374279.3	+	9	1537_1538	c.1087_1088insT	c.(1087-1089)tttfs	p.F363fs		NM_003358.1	NP_003349.1	Q16739	CEGT_HUMAN	UDP-glucose ceramide glucosyltransferase	363					epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity	p.I363V(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	12				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	GACAATATACATTTTTTTGTCT	0.401													19	119	---	---	---	---						T	114695180	-	T	114695179	7	5	21	1	0	1	1	0	0	0	0	0	16998	217	8	0	1121	0	UGCG	9	114695179	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	151939	114695179	26518252	379	1800										
RGS3	5998	broad.mit.edu	37	chr9	116356773	116356773	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aatgagtcccctggagccccTcccgcgggcaaggcagacaa	12	15	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:116356773T>C	ENST00000374140.2	+	23	3353	c.3144T>C	c.(3142-3144)ccT>ccC	p.P1048P	RGS3_ENST00000462403.1_Silent_p.P161P|RGS3_ENST00000350696.5_Silent_p.P1048P|RGS3_ENST00000394646.3_Silent_p.P441P|RGS3_ENST00000374134.3_Silent_p.P369P|RGS3_ENST00000462143.1_Silent_p.P369P|RGS3_ENST00000343817.5_Silent_p.P767P|RGS3_ENST00000342620.5_Silent_p.P18P	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1048					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						CTGGAGCCCCTCCCGCGGGCA	0.587													35	70					0	0	1	0	0	C	116356773	T	C	116356773	2	2	21	1	0	0	0	0	0	0	0	1	13355	1538	54	4		4	RGS3	9	116356773	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1661594	116356773	24856658	380	1801										
OR1L1	26737	broad.mit.edu	37	chr9	125424190	125424190	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtacttctttctaagcatcCtgtcttttgttgacatttgc	6	9	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:125424190C>T	ENST00000373686.1	+	1	346	c.346C>T	c.(346-348)Ctg>Ttg	p.L116L				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCTAAGCATCCTGTCTTTTGT	0.453													44	75					0	0	1	0	0	T	125424190	C	T	125424190	2	4	21	1	0	0	0	0	0	0	0	1	11010	680	24	3		3	OR1L1	9	125424190	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	9067417	125424190	15789241	381	1802										
SLC25A25	114789	broad.mit.edu	37	chr9	130860955	130860955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaagtccattttcaagctcaGtgtcttcatcccctcccagg	7	14	4	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:130860955G>A	ENST00000373064.5	+	1	373	c.110G>A	c.(109-111)aGt>aAt	p.S37N	SLC25A25_ENST00000373069.5_Intron|SLC25A25_ENST00000433501.1_5'UTR|SLC25A25_ENST00000432073.2_Intron|SLC25A25_ENST00000373068.2_Intron|SLC25A25_ENST00000373066.5_Intron	NM_052901.4	NP_443133.2	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	37					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						TTCAAGCTCAGTGTCTTCATC	0.582													66	94					0	0	1	0	0	A	130860955	G	A	130860955	3	1	21	1	0	0	0	0	1	0	0	0	14542	1029	36	3	600	3	SLC25A25	9	130860955	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5436765	130860955	10352476	382	1803										
LRRC8A	56262	broad.mit.edu	37	chr9	131670971	131670971	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgacatcaaggagatcccgCtgtggatctatagcctgaag	11	11	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:131670971C>T	ENST00000259324.5	+	3	2051	c.1528C>T	c.(1528-1530)Ctg>Ttg	p.L510L	LRRC8A_ENST00000372600.4_Silent_p.L510L|LRRC8A_ENST00000372599.3_Silent_p.L510L	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	510					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						GGAGATCCCGCTGTGGATCTA	0.612													24	28					0	0	1	0	0	T	131670971	C	T	131670971	2	4	21	1	0	0	0	0	0	0	0	1	9065	796	28	3		3	LRRC8A	9	131670971	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	810016	131670971	9542460	383	1804										
DOLK	22845	broad.mit.edu	37	chr9	131709514	131709514	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actgcaaacactactgccgcCtctgccagcaccgatccact	6	18	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:131709514C>A	ENST00000372586.3	-	1	384	c.69G>T	c.(67-69)gaG>gaT	p.E23D	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	23					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						CTACTGCCGCCTCTGCCAGCA	0.662													52	50					4.33383e-22	4.80502e-22	1	1	0	A	131709514	C	A	131709514	3	1	21	1	0	0	0	0	1	0	0	0	4730	680	24	5	1551	5	DOLK	9	131709514	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	38543	131709514	9503917	384	1805										
USP20	0	broad.mit.edu	37	chr9	132630693	132630693	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcccgcggaggcccagccccCgtcaccacggtcctccagcc	11	22	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:132630693C>A	ENST00000315480.4	+	11	1258	c.1100C>A	c.(1099-1101)cCg>cAg	p.P367Q	USP20_ENST00000372429.3_Missense_Mutation_p.P367Q|USP20_ENST00000358355.1_Missense_Mutation_p.P367Q			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	367					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				GCCCAGCCCCCGTCACCACGG	0.677													33	62					4.74835e-14	5.09084e-14	1	1	0	A	132630693	C	A	132630693	3	1	21	1	0	0	0	0	1	0	0	0	17111	652	23	5	1134	5	USP20	9	132630693	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	921179	132630693	8582738	385	1806										
POMT1	10585	broad.mit.edu	37	chr9	134381807	134381807	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caggttatttaggaggattcGatggcaattttttgtggaac	12	4	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:134381807G>A	ENST00000404875.2	+	0	190				POMT1_ENST00000419118.2_De_novo_Start_OutOfFrame|POMT1_ENST00000402686.3_Missense_Mutation_p.D83N|POMT1_ENST00000372228.3_Missense_Mutation_p.D83N|POMT1_ENST00000354713.4_Missense_Mutation_p.R47Q|POMT1_ENST00000341012.7_Missense_Mutation_p.D29N|POMT1_ENST00000541219.1_De_novo_Start_InFrame|POMT1_ENST00000423007.1_Missense_Mutation_p.D83N	NM_001136114.1	NP_001129586.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1						multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AGGAGGATTCGATGGCAATTT	0.348													83	122					0	0	1	0	0	A	134381807	G	A	134381807	1	1	21	1	0	0	0	0	0	0	0	0	12292	1058	37	1		1	POMT1	9	134381807	Translation_Start_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1751114	134381807	6831624	386	1807										
POMT1	10585	broad.mit.edu	37	chr9	134382768	134382768	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttccagaatacagtagcaaCgtgcctgtgtggtccctgcg	11	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:134382768C>T	ENST00000423007.1	+	5	736	c.294C>T	c.(292-294)aaC>aaT	p.N98N	POMT1_ENST00000419118.2_Intron|POMT1_ENST00000402686.3_Silent_p.N98N|POMT1_ENST00000372228.3_Silent_p.N98N|POMT1_ENST00000354713.4_Silent_p.N68N|POMT1_ENST00000404875.2_5'UTR|POMT1_ENST00000341012.7_Silent_p.N44N|POMT1_ENST00000541219.1_Intron	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	98					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		ACAGTAGCAACGTGCCTGTGT	0.557													54	80					0	0	1	0	0	T	134382768	C	T	134382768	2	4	21	1	0	0	0	0	0	0	0	1	12292	535	19	1		1	POMT1	9	134382768	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	961	134382768	6830663	387	1808										
DBH	1621	broad.mit.edu	37	chr9	136508685	136508685	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcaactactgccgccacgtgCtggccgcctgggccctgggt	13	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:136508685C>A	ENST00000393056.2	+	4	907	c.895C>A	c.(895-897)Ctg>Atg	p.L299M		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	299					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCGCCACGTGCTGGCCGCCTG	0.682													33	56					6.86731e-36	7.72132e-36	1	1	0	A	136508685	C	A	136508685	3	1	21	1	0	0	0	0	1	0	0	0	4274	796	28	5	909	5	DBH	9	136508685	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2125917	136508685	4704746	388	1809										
SARDH	1757	broad.mit.edu	37	chr9	136595269	136595269	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccgcaccccaaaatcatccGtccacacacgaatgccggtc	7	18	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:136595269G>A	ENST00000371872.4	-	5	988	c.731C>T	c.(730-732)aCg>aTg	p.T244M	SARDH_ENST00000439388.1_Missense_Mutation_p.T244M|SARDH_ENST00000298628.5_Missense_Mutation_p.T244M|SARDH_ENST00000371867.1_Missense_Mutation_p.T155M|SARDH_ENST00000422262.2_Missense_Mutation_p.T76M	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	244					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		AAAATCATCCGTCCACACACG	0.587													33	55					0	0	1	0	0	A	136595269	G	A	136595269	3	1	21	1	0	0	0	0	1	0	0	0	13893	1145	40	1	2093	1	SARDH	9	136595269	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	86584	136595269	4618162	389	1810										
VAV2	7410	broad.mit.edu	37	chr9	136633624	136633626	+	In_Frame_Del	DEL	CAC	CAC	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgatgcggctgtagatcctCaccacgtcaccctcccgcag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:136633624_136633626delCAC	ENST00000371851.1	-	27	2822_2824	c.2497_2499delGTG	c.(2497-2499)del	p.V833del	VAV2_ENST00000406606.3_In_Frame_Del_p.V804del|VAV2_ENST00000371850.3_In_Frame_Del_p.V843del			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	843	SH3 2.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		TGTAGATCCTCACCACGTCACCC	0.65													36	83	---	---	---	---						-	136633626	CAC	-	136633624	7	5	21	1	0	1	0	1	0	0	0	0	17191	813	29	0	115	0	VAV2	9	136633624	In_Frame_Del	DEL	CAC	TCGA-N7-A4Y0-01A-12D-A28R-08	38355	136633624	4579807	390	1811										
COL5A1	1289	broad.mit.edu	37	chr9	137687154	137687154	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggcatcactgggaagcctgGccccaaggtatgtttttggc	14	10	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:137687154G>C	ENST00000371817.3	+	34	3206	c.2792G>C	c.(2791-2793)gGc>gCc	p.G931A		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	931	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGGAAGCCTGGCCCCAAGGTA	0.602													43	78					0	0	1	0	0	C	137687154	G	C	137687154	3	2	21	1	0	0	0	0	1	0	0	0	3719	1203	42	5	2926	5	COL5A1	9	137687154	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1053530	137687154	3526277	391	1812										
OLFM1	10439	broad.mit.edu	37	chr9	138011985	138011985	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggccaccagatcctctacaaCgtgaccctcttccacgtcat	6	17	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:138011985C>T	ENST00000252854.4	+	6	1552	c.1365C>T	c.(1363-1365)aaC>aaT	p.N455N	OLFM1_ENST00000371793.3_Silent_p.N473N|OLFM1_ENST00000371796.3_Silent_p.N446N	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	473	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TCCTCTACAACGTGACCCTCT	0.572													23	43					0	0	1	0	0	T	138011985	C	T	138011985	2	4	21	1	0	0	0	0	0	0	0	1	10899	535	19	1		1	OLFM1	9	138011985	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	324831	138011985	3201446	392	1813										
MRPS2	51116	broad.mit.edu	37	chr9	138392884	138392884	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggttgggctttctcgggaaGgcgaccccccggcctgctcg	15	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:138392884G>A	ENST00000371785.1	+	3	293	c.84G>A	c.(82-84)aaG>aaA	p.K28K	MRPS2_ENST00000488610.1_3'UTR|MRPS2_ENST00000241600.5_Silent_p.K28K|C9orf116_ENST00000371791.1_Intron			Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	28					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome			large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		TTCTCGGGAAGGCGACCCCCC	0.711													17	25					0	0	1	0	0	A	138392884	G	A	138392884	2	1	21	1	0	0	0	0	0	0	0	1	9879	991	35	3		3	MRPS2	9	138392884	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	380899	138392884	2820547	393	1814										
QSOX2	169714	broad.mit.edu	37	chr9	139107074	139107074	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagtttccagagagaacacGggtaacccctcaactcagat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139107074delG	ENST00000358701.5	-	10	1323	c.1286delC	c.(1285-1287)cgfs	p.P429fs		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	429	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GAGAGAACACGGGTAACCCCT	0.458													17	43	---	---	---	---						-	139107074	G	-	139107074	7	5	21	1	0	1	0	1	0	0	0	0	12935	1116	39	0	822	0	QSOX2	9	139107074	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	714190	139107074	2106357	394	1815										
SNAPC4	6621	broad.mit.edu	37	chr9	139273254	139273254	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agagatctggccggggcccaGggcaggggcttgggaagcag	20	9	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139273254G>T	ENST00000298532.2	-	21	3393	c.3025C>A	c.(3025-3027)Ctg>Atg	p.L1009M		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	1009	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CCGGGGCCCAGGGCAGGGGCT	0.682													11	21					0.00010058	0.000102688	1	1	0	T	139273254	G	T	139273254	3	4	21	1	0	0	0	0	1	0	0	0	14890	991	35	5	1392	5	SNAPC4	9	139273254	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	166180	139273254	1940177	395	1816										
NOTCH1	4851	broad.mit.edu	37	chr9	139418329	139418329	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgcaggcatagtctgccacGcctctgcggtccaccacgtg	11	16	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139418329G>A	ENST00000277541.6	-	3	318	c.243C>T	c.(241-243)ggC>ggT	p.G81G	NOTCH1_ENST00000491649.1_5'UTR	NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	81	EGF-like 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGTCTGCCACGCCTCTGCGGT	0.697			"T, Mis, O"	TRB@	T-ALL					HNSCC(8;0.001)			13	11					0	0	1	0	0	A	139418329	G	A	139418329	2	1	21	1	0	0	0	0	0	0	0	1	10593	1074	38	1		1	NOTCH1	9	139418329	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	145075	139418329	1795102	396	1817										
FBXW5	54461	broad.mit.edu	37	chr9	139836499	139836499	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catggcggcaggggtgtaccGatctggtgtggggagtaggt	20	6	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139836499G>A	ENST00000325285.3	-	6	1174	c.1096_splice	c.e6+1	p.I365_splice	FBXW5_ENST00000483559.1_5'UTR	NM_018998.3	NP_061871.1	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	365							catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGGGTGTACCGATCTGGTGTG	0.662													8	18					0	0	1	0	0	A	139836499	G	A	139836499	5	1	21	1	0	0	0	0	0	0	1	0	5800	1072	37	1	621	1	FBXW5	9	139836499	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	418170	139836499	1376932	397	1818										
NPDC1	56654	broad.mit.edu	37	chr9	139935633	139935633	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccagtctgggctggggccggCccccgcctggggagggtgag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139935633delC	ENST00000371600.3	-	2	1172	c.500delG	c.(499-501)gcfs	p.G167fs	NPDC1_ENST00000371601.4_Frame_Shift_Del_p.G89fs|NPDC1_ENST00000488145.1_5'UTR			Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and control, 1	89	Pro/Ser/Thr-rich.					integral to membrane				NS(1)|large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	5	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CTGGGGCCGGCCCCCGCCTGG	0.687													4	3	---	---	---	---						-	139935633	C	-	139935633	7	5	21	1	0	1	0	1	0	0	0	0	10619	739	26	0	739	0	NPDC1	9	139935633	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	99134	139935633	1277798	398	1819										
EXD3	54932	broad.mit.edu	37	chr9	140243587	140243587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgggtgcggccggtgctgacGctttctgcaggccgggtggc	19	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:140243587G>A	ENST00000340951.4	-	16	2000	c.1805C>T	c.(1804-1806)gCg>gTg	p.A602V	EXD3_ENST00000342129.4_Missense_Mutation_p.A282V	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	602					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						CGGTGCTGACGCTTTCTGCAG	0.667													10	12					0	0	1	0	0	A	140243587	G	A	140243587	3	1	21	1	0	0	0	0	1	0	0	0	5326	1087	38	1	853	1	EXD3	9	140243587	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	307954	140243587	969844	399	1820										
LARP4B	23185	broad.mit.edu	37	chr10	890939	890939	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agataagcagaattccaatgTttttttaagtacttctcggg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:890939delT	ENST00000316157.3	-	5	527	c.487delA	c.(487-489)cafs	p.T163fs		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	163	HTH La-type RNA-binding.						nucleotide binding|RNA binding	p.T163P(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						AATTCCAATGTTTTTTTAAGT	0.353													52	64	---	---	---	---						-	890939	T	-	890939	7	5	21	1	0	1	0	1	0	0	0	0	8669	1725	60	0	1781	0	LARP4B	10	890939	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08		890939	134643808	400	1821										
NET1	10276	broad.mit.edu	37	chr10	5494824	5494824	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgctggatgtttttaggcaAtatatgaaatgtcccgaggt	11	5	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:5494824A>G	ENST00000355029.4	+	6	677	c.535A>G	c.(535-537)Ata>Gta	p.I179V	NET1_ENST00000380359.3_Missense_Mutation_p.I125V|NET1_ENST00000542715.1_5'UTR	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	179	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						TTTTTAGGCAATATATGAAAT	0.323													9	73					0	0	1	0	0	G	5494824	A	G	5494824	3	3	21	1	0	0	0	0	1	0	0	0	10384	101	4	4	654	4	NET1	10	5494824	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4603885	5494824	130039923	401	1822										
RBM17	84991	broad.mit.edu	37	chr10	6139070	6139070	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagtggagaccagtgactcAaaaacagaaggctggtccaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:6139070delA	ENST00000446108.1	+	2	686	c.42delA	c.(40-42)tcfs	p.S14fs	RBM17_ENST00000379888.4_Frame_Shift_Del_p.S14fs	NM_001145547.1	NP_001139019.1	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	14					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	19						CCAGTGACTCAAAAACAGAAG	0.463													54	127	---	---	---	---						-	6139070	A	-	6139070	7	5	21	1	0	1	0	1	0	0	0	0	13170	117	5	0	44	0	RBM17	10	6139070	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	644246	6139070	129395677	402	1823										
NUDT5	11164	broad.mit.edu	37	chr10	12214859	12214859	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgacaagcctgggtccataCagaccgctgtggagagaagg	14	9	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:12214859C>T	ENST00000491614.1	-	7	787	c.392G>A	c.(391-393)tGt>tAt	p.C131Y	NUDT5_ENST00000537776.1_Missense_Mutation_p.C131Y|NUDT5_ENST00000378940.3_Missense_Mutation_p.C131Y|NUDT5_ENST00000378927.3_Missense_Mutation_p.C131Y|NUDT5_ENST00000378937.3_Missense_Mutation_p.C144Y|NUDT5_ENST00000378952.3_5'UTR			Q9UKK9	NUDT5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 5	131	Nudix hydrolase.				D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)	8		Renal(717;0.228)				TGGGTCCATACAGACCGCTGT	0.507													17	25					0	0	1	0	0	T	12214859	C	T	12214859	3	4	21	1	0	0	0	0	1	0	0	0	10789	478	17	3	283	3	NUDT5	10	12214859	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6075789	12214859	123319888	403	1824										
CUBN	8029	broad.mit.edu	37	chr10	17126304	17126304	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagaactgtcactctggcatTgcagctccacgtgggtgaag	13	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:17126304T>C	ENST00000377833.4	-	17	2332	c.2267A>G	c.(2266-2268)cAa>cGa	p.Q756R		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	756	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACTCTGGCATTGCAGCTCCAC	0.443													38	41					0	0	1	0	0	C	17126304	T	C	17126304	3	2	21	1	0	0	0	0	1	0	0	0	4074	1812	63	4	8808	4	CUBN	10	17126304	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4911445	17126304	118408443	404	1825										
CACNB2	783	broad.mit.edu	37	chr10	18787305	18787305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caaagcccgttgcatttgcgGttcggacaaatgtcagctac	10	11	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:18787305G>A	ENST00000396576.2	+	3	691	c.190G>A	c.(190-192)Gtt>Att	p.V64I	CACNB2_ENST00000377331.2_Missense_Mutation_p.V91I|CACNB2_ENST00000377319.3_Missense_Mutation_p.V64I|CACNB2_ENST00000377328.1_Missense_Mutation_p.V119I|CACNB2_ENST00000377329.4_Missense_Mutation_p.V65I|CACNB2_ENST00000352115.6_Missense_Mutation_p.V119I|CACNB2_ENST00000324631.7_Missense_Mutation_p.V119I|CACNB2_ENST00000377315.4_Missense_Mutation_p.V71I|CACNB2_ENST00000282343.8_Missense_Mutation_p.V91I	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	119					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGCATTTGCGGTTCGGACAAA	0.448													20	32					0	0	1	0	0	A	18787305	G	A	18787305	3	1	21	1	0	0	0	0	1	0	0	0	2571	1261	44	3	589	3	CACNB2	10	18787305	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1661001	18787305	116747442	405	1826										
KIAA1217	56243	broad.mit.edu	37	chr10	24831988	24831988	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aactattcccaggaaactgtGcctaaggccagtttcggttt	9	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:24831988G>A	ENST00000376451.2	+	14	3098	c.2838G>A	c.(2836-2838)gtG>gtA	p.V946V	KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376454.3_Silent_p.V1263V			Q5T5P2	SKT_HUMAN	KIAA1217	1263					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGGAAACTGTGCCTAAGGCCA	0.383													36	29					0	0	1	0	0	A	24831988	G	A	24831988	2	1	21	1	0	0	0	0	0	0	0	1	8257	1306	46	3		3	KIAA1217	10	24831988	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6044683	24831988	110702759	406	1827										
KIAA1217	56243	broad.mit.edu	37	chr10	24832391	24832391	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgtccaggttctttccagtGgggaggtgcatgatattgtt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:24832391delG	ENST00000376451.2	+	14	3501	c.3241delG	c.(3241-3243)ggfs	p.G1081fs	KIAA1217_ENST00000376454.3_Frame_Shift_Del_p.G1398fs|KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000458595.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1398					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TCTTTCCAGTGGGGAGGTGCA	0.458													41	54	---	---	---	---						-	24832391	G	-	24832391	7	5	21	1	0	1	0	1	0	0	0	0	8257	1348	47	0	4266	0	KIAA1217	10	24832391	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	403	24832391	110702356	407	1828										
ARHGAP21	57584	broad.mit.edu	37	chr10	24874838	24874838	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgcccagtgtctcactttcTtttttggactcctctttagt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:24874838delT	ENST00000396432.2	-	26	4866	c.4380delA	c.(4378-4380)aafs	p.K1460fs		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1459					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TCTCACTTTCTTTTTTGGACT	0.393													70	129	---	---	---	---						-	24874838	T	-	24874838	7	5	21	1	0	1	0	1	0	0	0	0	868	1606	56	0	1500	0	ARHGAP21	10	24874838	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	42447	24874838	110659909	408	1829										
GPR158	57512	broad.mit.edu	37	chr10	25464418	25464418	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgggattgggagctgttggCgccagccgcgacccccaagg	16	13	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:25464418C>T	ENST00000376351.3	+	1	428	c.69C>T	c.(67-69)ggC>ggT	p.G23G	GPR158-AS1_ENST00000449643.1_RNA	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	23						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAGCTGTTGGCGCCAGCCGCG	0.667													35	92					0	0	1	0	0	T	25464418	C	T	25464418	2	4	21	1	0	0	0	0	0	0	0	1	6702	755	27	1		1	GPR158	10	25464418	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	589580	25464418	110070329	409	1830										
GPR158	57512	broad.mit.edu	37	chr10	25861746	25861746	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagatttcacttattggccaGgggaaaacatccgatcacct					rs138208272		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:25861746delG	ENST00000376351.3	+	7	2042	c.1683delG	c.(1681-1683)cafs	p.Q561fs		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	561						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TTATTGGCCAGGGGAAAACAT	0.453													24	41	---	---	---	---						-	25861746	G	-	25861746	7	5	21	1	0	1	0	1	0	0	0	0	6702	991	35	0	1709	0	GPR158	10	25861746	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	397328	25861746	109673001	410	1831										
MYO3A	53904	broad.mit.edu	37	chr10	26436415	26436415	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agagacactcttcctactgaCattgtgctacttttgaggtc	8	10	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:26436415C>T	ENST00000265944.5	+	23	2728	c.2562C>T	c.(2560-2562)gaC>gaT	p.D854D	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	854	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TTCCTACTGACATTGTGCTAC	0.393													34	75					0	0	1	0	0	T	26436415	C	T	26436415	2	4	21	1	0	0	0	0	0	0	0	1	10123	477	17	3		3	MYO3A	10	26436415	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	574669	26436415	109098332	411	1832										
ACBD5	91452	broad.mit.edu	37	chr10	27494154	27494154	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgggctgaggagcagtctgCaatgttgatgttgatgattt	15	4	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:27494154C>T	ENST00000396271.3	-	11	1554	c.1428G>A	c.(1426-1428)ttG>ttA	p.L476L	ACBD5_ENST00000375905.4_Silent_p.L441L|ACBD5_ENST00000375901.1_Silent_p.L367L|ACBD5_ENST00000375897.3_Silent_p.L299L|ACBD5_ENST00000375888.1_Silent_p.L485L|ACBD5_ENST00000476758.1_5'UTR	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	485					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						GAGCAGTCTGCAATGTTGATG	0.313													34	63					0	0	1	0	0	T	27494154	C	T	27494154	2	4	21	1	0	0	0	0	0	0	0	1	125	709	25	3		3	ACBD5	10	27494154	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1057739	27494154	108040593	412	1833										
PTCHD3	374308	broad.mit.edu	37	chr10	27702951	27702951	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcgtccagcatcgacggccGggggggtgcatcgtccccct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:27702951delG	ENST00000438700.3	-	1	346	c.229delC	c.(229-231)ggfs	p.R77fs		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	77					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						ATCGACGGCCGGGGGGGTGCA	0.716													7	99	---	---	---	---						-	27702951	G	-	27702951	7	5	21	1	0	1	0	1	0	0	0	0	12782	1115	39	0	2090	0	PTCHD3	10	27702951	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	208797	27702951	107831796	413	1834										
SVIL	6840	broad.mit.edu	37	chr10	29812587	29812587	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttagattccttatggctgtCtccttccctggctcggttca	8	12	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:29812587C>A	ENST00000375398.2	-	17	3405	c.2956G>T	c.(2956-2958)Gac>Tac	p.D986Y	SVIL_ENST00000375400.3_Missense_Mutation_p.D560Y|SVIL_ENST00000355867.4_Missense_Mutation_p.D986Y			O95425	SVIL_HUMAN	supervillin	986					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TTATGGCTGTCTCCTTCCCTG	0.532													37	58					1.36161e-19	1.50017e-19	1	1	0	A	29812587	C	A	29812587	3	1	21	1	0	0	0	0	1	0	0	0	15476	913	32	2	3784	2	SVIL	10	29812587	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2109636	29812587	105722160	414	1835										
SVIL	6840	broad.mit.edu	37	chr10	29822253	29822253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgctggggaccctatcaaagGctgagtgctcagactgaaat	12	9	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:29822253G>A	ENST00000375398.2	-	10	1492	c.1043C>T	c.(1042-1044)gCc>gTc	p.A348V	SVIL_ENST00000375400.3_Intron|SVIL_ENST00000355867.4_Missense_Mutation_p.A348V			O95425	SVIL_HUMAN	supervillin	348					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCTATCAAAGGCTGAGTGCTC	0.572													50	41					0	0	1	0	0	A	29822253	G	A	29822253	3	1	21	1	0	0	0	0	1	0	0	0	15476	1203	42	3	5725	3	SVIL	10	29822253	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9666	29822253	105712494	415	1836										
ZNF22	7570	broad.mit.edu	37	chr10	45499133	45499133	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcagcatcgacggatccataCgggggaaaagccctacaaat	10	11	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:45499133C>T	ENST00000298299.3	+	2	910	c.317C>T	c.(316-318)aCg>aTg	p.T106M	CEP164P1_ENST00000456938.2_RNA	NM_006963.4	NP_008894.2	P17026	ZNF22_HUMAN	zinc finger protein 22	106					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				CGGATCCATACGGGGGAAAAG	0.418													24	60					0	0	1	0	0	T	45499133	C	T	45499133	3	4	21	1	0	0	0	0	1	0	0	0	17831	536	19	1	319	1	ZNF22	10	45499133	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	15676880	45499133	90035614	416	1837										
PARG	8505	broad.mit.edu	37	chr10	51069693	51069693	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtaagtgacatgcaatcgtgTcaagggtttttcacatctac	9	8	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:51069693T>C	ENST00000402038.3	-	8	690	c.691A>G	c.(691-693)Aca>Gca	p.T231A		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	716					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGCAATCGTGTCAAGGGTTTT	0.358													8	8					0	0	1	0	0	C	51069693	T	C	51069693	3	2	21	1	0	0	0	0	1	0	0	0	11494	1667	58	4	812	4	PARG	10	51069693	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	5570560	51069693	84465054	417	1838										
ANK3	288	broad.mit.edu	37	chr10	61832912	61832912	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccttcacagtcctgtccaccCtatcttcatatatcaacttc	2	16	4	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:61832912C>A	ENST00000280772.1	-	37	7918	c.7727G>T	c.(7726-7728)aGg>aTg	p.R2576M	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2576					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCTGTCCACCCTATCTTCATA	0.423													37	104					6.53348e-20	7.20737e-20	1	1	0	A	61832912	C	A	61832912	3	1	21	1	0	0	0	0	1	0	0	0	618	681	24	5	5747	5	ANK3	10	61832912	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	10763219	61832912	73701835	418	1839										
RTKN2	219790	broad.mit.edu	37	chr10	63995969	63995969	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggttatagaagattcttctGtacagcaactatacacttcc	6	9	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:63995969G>A	ENST00000373789.3	-	6	638	c.542C>T	c.(541-543)aCa>aTa	p.T181I	RTKN2_ENST00000315289.2_5'UTR|RTKN2_ENST00000395265.1_Missense_Mutation_p.T181I	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	181					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AGATTCTTCTGTACAGCAACT	0.348													18	41					0	0	1	0	0	A	63995969	G	A	63995969	3	1	21	1	0	0	0	0	1	0	0	0	13774	1377	48	3	1315	3	RTKN2	10	63995969	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2163057	63995969	71538778	419	1840										
LRRTM3	347731	broad.mit.edu	37	chr10	68686815	68686815	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaaggcaaaatggtatattgTgaatctcagaaattacagga	10	4	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:68686815T>C	ENST00000361320.4	+	2	719	c.141T>C	c.(139-141)tgT>tgC	p.C47C	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	47	LRRNT.					integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGGTATATTGTGAATCTCAGA	0.423													20	70					0	0	1	0	0	C	68686815	T	C	68686815	2	2	21	1	0	0	0	0	0	0	0	1	9085	1702	59	4		4	LRRTM3	10	68686815	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4690846	68686815	66847932	420	1841										
C10orf54	64115	broad.mit.edu	37	chr10	73511467	73511467	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccggggcctggaggagacaGgggggtgctgggctccgaaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:73511467delG	ENST00000394957.3	-	6	914	c.856delC	c.(856-858)tgfs	p.L286fs	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	286						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						GGAGGAGACAGGGGGGTGCTG	0.617													29	72	---	---	---	---						-	73511467	G	-	73511467	7	5	21	1	0	1	0	1	0	0	0	0	1611	991	35	0	87	0	C10orf54	10	73511467	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4824652	73511467	62023280	421	1842										
MYOZ1	58529	broad.mit.edu	37	chr10	75393728	75393728	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caggtcaatgccaagttccaTtttttgctgggggtcaaccc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:75393728delT	ENST00000359322.4	-	5	962	c.598delA	c.(598-600)tgfs	p.M200fs		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	200					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					CCAAGTTCCATTTTTTGCTGG	0.517													47	141	---	---	---	---						-	75393728	T	-	75393728	7	5	21	1	0	1	0	1	0	0	0	0	10142	1493	52	0	309	0	MYOZ1	10	75393728	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1882261	75393728	60141019	422	1843										
DLG5	9231	broad.mit.edu	37	chr10	79552204	79552204	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcacagcattctcctagagCgggcaggctggaatccacag	12	12	1	1	rs148200124		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:79552204C>T	ENST00000372391.2	-	32	5759	c.5754G>A	c.(5752-5754)ccG>ccA	p.P1918P	RP13-39P12.3_ENST00000434097.2_RNA|DLG5_ENST00000372388.2_Silent_p.P1578P	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1918					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCTCCTAGAGCGGGCAGGCTG	0.532													69	148					0	0	1	0	0	T	79552204	C	T	79552204	2	4	21	1	0	0	0	0	0	0	0	1	4586	755	27	1		1	DLG5	10	79552204	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4158476	79552204	55982543	423	1844										
PTEN	5728	broad.mit.edu	37	chr10	89692910	89692910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagctggaaagggacgaactGgtgtaatgatatgtgcatat	13	4	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:89692910G>A	ENST00000371953.3	+	5	1751	c.394G>A	c.(394-396)Ggt>Agt	p.G132S		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	132	Phosphatase tensin-type.		G -> V (in one patient with clinical findings suggesting hamartoma tumor syndrome).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.G132S(3)|p.Y27fs*1(2)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131fs*42(1)|p.F56fs*2(1)|p.K128fs*47(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGGACGAACTGGTGTAATGAT	0.398		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			122	79					0	0	1	0	0	A	89692910	G	A	89692910	3	1	21	1	0	0	0	0	1	0	0	0	12786	1348	47	3	412	3	PTEN	10	89692910	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	10140706	89692910	45841837	424	1845										
PTEN	5728	broad.mit.edu	37	chr10	89717674	89717675	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccaattcaggacccacacgaINScgggaagacaagttcatgta							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:89717674_89717675insC	ENST00000371953.3	+	7	2056_2057	c.699_700insC	c.(697-702)cggggafs	p.RG233fs	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.R234fs*11(3)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R234fs*24(1)|p.G165_*404del(1)|p.?(1)|p.R234fs*10(1)|p.R233fs*10(1)|p.R234fs*27(1)|p.R234W(1)|p.R234fs*23(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R234fs*3(1)|p.R234fs*26(1)|p.R234fs*4(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GACCCACACGACGGGAAGACAA	0.416		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			43	112	---	---	---	---						C	89717675	-	C	89717674	7	5	21	1	0	1	1	0	0	0	0	0	12786	262	10	0	725	0	PTEN	10	89717674	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	24764	89717674	45817073	425	1846										
IFIT1	3434	broad.mit.edu	37	chr10	91163163	91163163	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccagtggtagaagaaacaatGcaagacatacatttccacta	7	9	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:91163163G>A	ENST00000546318.1	+	2	2325	c.1038G>A	c.(1036-1038)atG>atA	p.M346I	IFIT1_ENST00000371804.3_Missense_Mutation_p.M377I|LIPA_ENST00000371837.1_Intron	NM_001270928.1|NM_001270929.1|NM_001270930.1	NP_001257857.1|NP_001257858.1|NP_001257859.1	P09914	IFIT1_HUMAN	interferon-induced protein with tetratricopeptide repeats 1	377					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	15						AAGAAACAATGCAAGACATAC	0.338													48	25					0	0	1	0	0	A	91163163	G	A	91163163	3	1	21	1	0	0	0	0	1	0	0	0	7564	1319	46	3	1137	3	IFIT1	10	91163163	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1445489	91163163	44371584	426	1847										
HECTD2	143279	broad.mit.edu	37	chr10	93221892	93221892	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	taacaccattgaagactctgGgattaatgctaaatttgtga	8	6	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:93221892G>T	ENST00000446394.1	+	5	651	c.551G>T	c.(550-552)gGg>gTg	p.G184V	HECTD2_ENST00000371681.4_Missense_Mutation_p.G184V|HECTD2_ENST00000298068.5_Missense_Mutation_p.G184V			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	184					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						GAAGACTCTGGGATTAATGCT	0.294													43	164					2.64894e-19	2.91118e-19	1	1	0	T	93221892	G	T	93221892	3	4	21	1	0	0	0	0	1	0	0	0	7080	1232	43	5	569	5	HECTD2	10	93221892	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2058729	93221892	42312855	427	1848										
KIF11	3832	broad.mit.edu	37	chr10	94408154	94408154	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtttgactaagcttaattgCtttctggaacaggatctgaa	10	6	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:94408154C>T	ENST00000260731.3	+	19	2823	c.2733C>T	c.(2731-2733)tgC>tgT	p.C911C		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	911					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCTTAATTGCTTTCTGGAAC	0.299													30	94					0	0	1	0	0	T	94408154	C	T	94408154	2	4	21	1	0	0	0	0	0	0	0	1	8313	805	28	3		3	KIF11	10	94408154	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1186262	94408154	41126593	428	1849										
TBC1D12	23232	broad.mit.edu	37	chr10	96162514	96162514	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcgtcggcgctgtggagccGccggaggaggctgacgagga	21	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:96162514G>A	ENST00000225235.4	+	1	254	c.144G>A	c.(142-144)ccG>ccA	p.P48P		NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	48						intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CTGTGGAGCCGCCggaggagg	0.726													4	9					0	0	1	0	0	A	96162514	G	A	96162514	2	1	21	1	0	0	0	0	0	0	0	1	15657	1074	38	1		1	TBC1D12	10	96162514	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1754360	96162514	39372233	429	1850										
GOT1	2805	broad.mit.edu	37	chr10	101163312	101163312	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttggaccaagtaatccgcacGatcttctccatctgggaaag	9	11	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:101163312G>A	ENST00000370508.5	-	7	900	c.873C>T	c.(871-873)atC>atT	p.I291I	GOT1_ENST00000543866.1_Silent_p.I270I	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	291					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TAATCCGCACGATCTTCTCCA	0.537													93	67					0	0	1	0	0	A	101163312	G	A	101163312	2	1	21	1	0	0	0	0	0	0	0	1	6617	1048	37	1		1	GOT1	10	101163312	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5000798	101163312	34371435	430	1851										
ACTR1A	10121	broad.mit.edu	37	chr10	104241927	104241927	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggggcccggaatcgggaaggAccaatctgcaggtaggaggg	19	8	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:104241927A>G	ENST00000369905.4	-	8	819	c.756T>C	c.(754-756)ggT>ggC	p.G252G	ACTR1A_ENST00000487599.1_Silent_p.G252G|ACTR1A_ENST00000446605.2_Silent_p.G205G|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000545684.1_Silent_p.G178G	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	252					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		ATCGGGAAGGACCAATCTGCA	0.572													51	150					0	0	1	0	0	G	104241927	A	G	104241927	2	3	21	1	0	0	0	0	0	0	0	1	209	262	10	4		4	ACTR1A	10	104241927	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3078615	104241927	31292820	431	1852										
CCDC147	159686	broad.mit.edu	37	chr10	106121801	106121801	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaaattgaaaaggcctggaaGatggtggactcagcctatga	13	6	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:106121801G>T	ENST00000369704.3	+	3	446	c.312G>T	c.(310-312)aaG>aaT	p.K104N	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	104										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGGCCTGGAAGATGGTGGACT	0.448													42	26					3.77016e-25	4.20665e-25	1	1	0	T	106121801	G	T	106121801	3	4	21	1	0	0	0	0	1	0	0	0	2799	933	33	2	322	2	CCDC147	10	106121801	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1879874	106121801	29412946	432	1853										
SORCS3	22986	broad.mit.edu	37	chr10	106976790	106976790	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcgaggacggcatcaagcacGtgtataagagtgcggggatc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:106976790delG	ENST00000369701.3	+	19	2871	c.2644delG	c.(2644-2646)tgfs	p.V882fs	SORCS3_ENST00000369699.4_Frame_Shift_Del_p.V168fs	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	882	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CATCAAGCACGTGTATAAGAG	0.517													32	76	---	---	---	---						-	106976790	G	-	106976790	7	5	21	1	0	1	0	1	0	0	0	0	14985	1145	40	0	2718	0	SORCS3	10	106976790	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	854989	106976790	28557957	433	1854										
ADRA2A	150	broad.mit.edu	37	chr10	112837856	112837856	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggaacgggaccgaggcgccGgggggcggcgcccgggccac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:112837856delG	ENST00000280155.2	+	1	1067	c.102delG	c.(100-102)ccfs	p.P34fs		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	19					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding	p.G22fs*>430(1)		breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CCGAggcgccggggggcggcg	0.726													5	10	---	---	---	---						-	112837856	G	-	112837856	7	5	21	1	0	1	0	1	0	0	0	0	336	1103	39	0	104	0	ADRA2A	10	112837856	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5861066	112837856	22696891	434	1855										
TCF7L2	6934	broad.mit.edu	37	chr10	114900983	114900984	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagcaccctcaccatgtccaINSccccctcacgcctcttatca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:114900983_114900984insC	ENST00000355995.4	+	6	1100_1101	c.593_594insC	c.(592-594)cccfs	p.P198fs	TCF7L2_ENST00000349937.2_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000543371.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000352065.5_Frame_Shift_Ins_p.P175fs|TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000355717.4_Frame_Shift_Ins_p.P222fs|TCF7L2_ENST00000536810.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000538897.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000369395.1_Frame_Shift_Ins_p.P223fs|TCF7L2_ENST00000534894.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000369397.4_Frame_Shift_Ins_p.P175fs|TCF7L2_ENST00000545257.1_Frame_Shift_Ins_p.P198fs			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	198	Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CACCATGTCCACCCCCTCACGC	0.569			T	VTI1A	colorectal								43	140	---	---	---	---						C	114900984	-	C	114900983	7	5	21	1	0	1	1	0	0	0	0	0	15757	159	6	0	760	0	TCF7L2	10	114900983	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	2063127	114900983	20633764	435	1856										
NRAP	4892	broad.mit.edu	37	chr10	115410306	115410306	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtcctctgtgtatctcaccTgaaatgaaaaaacatgtgaa	7	8	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:115410306T>C	ENST00000369358.4	-	8	920		c.e8-2		NRAP_ENST00000369360.3_Splice_Site|NRAP_ENST00000359988.3_Splice_Site|NRAP_ENST00000360478.3_Splice_Site			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein							fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GTATCTCACCTGAAATGAAAA	0.458													19	41					0	0	1	0	0	C	115410306	T	C	115410306	5	2	21	1	0	0	0	0	0	0	1	0	10685	1594	55	4	4658	4	NRAP	10	115410306	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	509323	115410306	20124441	436	1857										
ATRNL1	26033	broad.mit.edu	37	chr10	117226764	117226765	+	Splice_Site	INS	-	-	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtctgtcggttcaacaggtINSaaaaaaatgttgatgtcata							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:117226764_117226765insA	ENST00000355044.3	+	23	3622		c.e23+2		ATRNL1_ENST00000423111.2_Splice_Site|ATRNL1_ENST00000303745.7_Intron	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1							integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTTCAACAGGTAAAAAAATGTT	0.287													14	37	---	---	---	---						A	117226765	-	A	117226764	8	5	21	1	0	1	1	0	0	0	1	0	1205	1652	57	0	3588	0	ATRNL1	10	117226764	Splice_Site	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	1816458	117226764	18307983	437	1858										
RAB11FIP2	22841	broad.mit.edu	37	chr10	119768725	119768725	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	taccctgcagtggcatcaaaGgggttgctgtcctagaacag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:119768725delG	ENST00000355624.3	-	5	1762	c.1323delC	c.(1321-1323)ccfs	p.P441fs	RAB11FIP2_ENST00000476207.1_5'UTR|RAB11FIP2_ENST00000369199.3_Frame_Shift_Del_p.P461fs	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	441	FIP-RBD.				protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		TGGCATCAAAGGGGTTGCTGT	0.428													11	155	---	---	---	---						-	119768725	G	-	119768725	7	5	21	1	0	1	0	1	0	0	0	0	12945	987	35	0	219	0	RAB11FIP2	10	119768725	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2541961	119768725	15766022	438	1859										
FGFR2	2263	broad.mit.edu	37	chr10	123279677	123279677	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaggatgggccggtgaggcGatcgctctggtggagagagg	22	6	1	2	rs121918498		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:123279677G>C	ENST00000358487.5	-	7	1027	c.755C>G	c.(754-756)tCg>tGg	p.S252W	FGFR2_ENST00000369056.1_Missense_Mutation_p.S252W|FGFR2_ENST00000369061.4_Intron|FGFR2_ENST00000369059.1_Missense_Mutation_p.S137W|FGFR2_ENST00000478859.1_Missense_Mutation_p.S24W|FGFR2_ENST00000457416.2_Missense_Mutation_p.S252W|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000356226.4_Missense_Mutation_p.S137W|FGFR2_ENST00000360144.3_Missense_Mutation_p.S163W|FGFR2_ENST00000351936.6_Missense_Mutation_p.S252W|FGFR2_ENST00000346997.2_Missense_Mutation_p.S252W|FGFR2_ENST00000357555.5_Missense_Mutation_p.S163W|FGFR2_ENST00000369060.4_Missense_Mutation_p.S252W	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	252			S -> F (in APRS; requires 2 nucleotide substitutions).|S -> L (in CS).|S -> W (in APRS and PS; common mutation).|SP -> FS (in PS).		angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.S252W(68)|p.S163W(13)		breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CCGGTGAGGCGATCGCTCTGG	0.557	S252W(MFE280_ENDOMETRIUM)	5	Mis		"gastric. NSCLC, endometrial"		"Crouzon, Pfeiffer, and Apert syndromes"		Saethre-Chotzen syndrome;Apert syndrome				12	27					0	0	1	0	0	C	123279677	G	C	123279677	3	2	21	1	0	0	0	0	1	0	0	0	5898	1059	37	2	2014	2	FGFR2	10	123279677	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3510952	123279677	12255070	439	1860										
FGFR2	2263	broad.mit.edu	37	chr10	123325123	123325123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atccttagtccaactgatcaCggcggcatctttcaacaggc	8	13	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:123325123C>T	ENST00000358487.5	-	3	477	c.205G>A	c.(205-207)Gtg>Atg	p.V69M	FGFR2_ENST00000369056.1_Missense_Mutation_p.V69M|FGFR2_ENST00000369061.4_Missense_Mutation_p.V69M|FGFR2_ENST00000369059.1_Intron|FGFR2_ENST00000457416.2_Missense_Mutation_p.V69M|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000359354.2_Missense_Mutation_p.V69M|FGFR2_ENST00000356226.4_Intron|FGFR2_ENST00000360144.3_Intron|FGFR2_ENST00000351936.6_Missense_Mutation_p.V69M|FGFR2_ENST00000346997.2_Missense_Mutation_p.V69M|FGFR2_ENST00000357555.5_Intron|FGFR2_ENST00000369060.4_Missense_Mutation_p.V69M	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	69	Ig-like C2-type 1.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CAACTGATCACGGCGGCATCT	0.552		5	Mis		"gastric. NSCLC, endometrial"		"Crouzon, Pfeiffer, and Apert syndromes"		Saethre-Chotzen syndrome;Apert syndrome				81	157					0	0	1	0	0	T	123325123	C	T	123325123	3	4	21	1	0	0	0	0	1	0	0	0	5898	536	19	1	2580	1	FGFR2	10	123325123	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	45446	123325123	12209624	440	1861										
FAM53B	9679	broad.mit.edu	37	chr10	126311887	126311887	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcccaggggccccgcggtccCgccaggctgcagccggctcc	14	20	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:126311887C>A	ENST00000337318.3	-	5	1404	c.1193G>T	c.(1192-1194)cGg>cTg	p.R398L	FAM53B_ENST00000392754.3_Missense_Mutation_p.R398L|RP11-12J10.3_ENST00000494792.1_Intron	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	398										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		CCCGCGGTCCCGCCAGGCTGC	0.672													65	42					2.79145e-41	3.15884e-41	1	1	0	A	126311887	C	A	126311887	3	1	21	1	0	0	0	0	1	0	0	0	5615	652	23	5	79	5	FAM53B	10	126311887	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2986764	126311887	9222860	441	1862										
FAM53B	9679	broad.mit.edu	37	chr10	126312029	126312029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcagggaccggggtcccagCgggggtcctgccccctgggc	17	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:126312029C>T	ENST00000337318.3	-	5	1262	c.1051G>A	c.(1051-1053)Gct>Act	p.A351T	FAM53B_ENST00000392754.3_Missense_Mutation_p.A351T|RP11-12J10.3_ENST00000494792.1_Intron	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	351										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GGGGTCCCAGCGGGGGTCCTG	0.706													5	17					0	0	1	0	0	T	126312029	C	T	126312029	3	4	21	1	0	0	0	0	1	0	0	0	5615	768	27	1	221	1	FAM53B	10	126312029	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	142	126312029	9222718	442	1863										
JAKMIP3	282973	broad.mit.edu	37	chr10	133958682	133958682	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gacctggagaaggccctggcGgagcaggggcaggtgagcct	19	10	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:133958682G>A	ENST00000298622.4	+	11	1812	c.1674G>A	c.(1672-1674)gcG>gcA	p.A558A	JAKMIP3_ENST00000477275.1_3'UTR	NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGCCCTGGCGGAGCAGGGGC	0.607													11	29					0	0	1	0	0	A	133958682	G	A	133958682	2	1	21	1	0	0	0	0	0	0	0	1	7985	1103	39	1		1	JAKMIP3	10	133958682	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7646653	133958682	1576065	443	1864										
PWWP2B	170394	broad.mit.edu	37	chr10	134218255	134218255	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gatgcagctggggtccagctCcccccctcctgcccgcgggg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:134218255delC	ENST00000305233.5	+	2	310	c.251delC	c.(250-252)tcfs	p.S84fs	PWWP2B_ENST00000368609.4_Frame_Shift_Del_p.S84fs	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	84										central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GGGTCCAGCTCCCCCCCTCCT	0.746													7	123	---	---	---	---						-	134218255	C	-	134218255	7	5	21	1	0	1	0	1	0	0	0	0	12897	855	30	0	257	0	PWWP2B	10	134218255	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	259573	134218255	1316492	444	1865										
GPR123	84435	broad.mit.edu	37	chr10	134941910	134941910	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caccctggtcacctgtgtgtActtcctgggcacctacgtgc	10	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:134941910A>G	ENST00000607359.1	+	16	2735	c.2735A>G	c.(2734-2736)tAc>tGc	p.Y912C	GPR123_ENST00000392606.2_Missense_Mutation_p.Y96C|GPR123_ENST00000392607.3_Missense_Mutation_p.Y193C			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	193						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ACCTGTGTGTACTTCCTGGGC	0.701													20	22					0	0	1	0	0	G	134941910	A	G	134941910	3	3	21	1	0	0	0	0	1	0	0	0	6676	391	14	4	600	4	GPR123	10	134941910	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	723655	134941910	592837	445	1866										
RIC8A	60626	broad.mit.edu	37	chr11	214328	214328	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagcagcagctctcctcggAccctgactcggaccctgact	11	16	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:214328A>G	ENST00000526104.1	+	10	2918	c.1574A>G	c.(1573-1575)gAc>gGc	p.D525G	RIC8A_ENST00000531541.1_3'UTR|RIC8A_ENST00000527696.1_Missense_Mutation_p.D519G|RIC8A_ENST00000325207.5_Missense_Mutation_p.D531G			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	525						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTCTCctcggaccctgactcg	0.597													4	10					0	0	1	0	0	G	214328	A	G	214328	3	3	21	1	0	0	0	0	1	0	0	0	13404	275	10	4	1630	4	RIC8A	11	214328	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08		214328	134792188	446	1867										
RASSF7	8045	broad.mit.edu	37	chr11	563280	563280	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaccggggctgcgctgccacCgcccccacggcctgacaggg	15	18	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:563280C>A	ENST00000397583.3	+	4	1347	c.914C>A	c.(913-915)cCg>cAg	p.P305Q	RASSF7_ENST00000454668.2_Missense_Mutation_p.P305Q|RASSF7_ENST00000431809.1_Missense_Mutation_p.P305Q|RASSF7_ENST00000397582.3_Missense_Mutation_p.P305Q|RASSF7_ENST00000344375.4_Missense_Mutation_p.P305Q	NM_003475.3	NP_003466.1	Q02833	RASF7_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	305	Pro-rich.				regulation of transcription, DNA-dependent|signal transduction	nucleus	DNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(3)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCGCTGCCACCGCCCCCACGG	0.682													7	14					2.0095e-06	2.08067e-06	1	1	0	A	563280	C	A	563280	3	1	21	1	0	0	0	0	1	0	0	0	13142	652	23	5	924	5	RASSF7	11	563280	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	348952	563280	134443236	447	1868										
MUC5B	727897	broad.mit.edu	37	chr11	1265997	1265997	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcccagggacggcacgcacGcttccagtgtggatcagcac	13	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:1265997G>A	ENST00000447027.1	+	31	7954	c.7896G>A	c.(7894-7896)acG>acA	p.T2632T	MUC5B_ENST00000529681.1_Silent_p.T2629T|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2629	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.T2608T(1)|p.T2629T(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGGCACGCACGCTTCCAGTGT	0.637													57	79					0	0	1	0	0	A	1265997	G	A	1265997	2	1	21	1	0	0	0	0	0	0	0	1	10026	1074	38	1		1	MUC5B	11	1265997	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	702717	1265997	133740519	448	1869										
PHLDA2	7262	broad.mit.edu	37	chr11	2950201	2950201	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgagggctcggagggtgcggCggccgcggcagccacggcgt	21	13	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:2950201C>T	ENST00000314222.4	-	1	484	c.394G>A	c.(394-396)Gcc>Acc	p.A132T		NM_003311.3	NP_003302.1	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain, family A, member 2	132	Poly-Ala.				apoptosis	cytoplasm|membrane				central_nervous_system(1)	1		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGGGTGCGGCGGCCGCGGCA	0.756													6	2					0	0	1	0	0	T	2950201	C	T	2950201	3	4	21	1	0	0	0	0	1	0	0	0	11896	768	27	1	68	1	PHLDA2	11	2950201	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1684204	2950201	132056315	449	1870										
OR51A7	119687	broad.mit.edu	37	chr11	4928979	4928979	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaccgctttcttgccattcAcaatcccttaagatacagtt	6	12	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:4928979A>G	ENST00000359350.4	+	1	380	c.380A>G	c.(379-381)cAc>cGc	p.H127R	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTGCCATTCACAATCCCTTA	0.403													34	44					0	0	1	0	0	G	4928979	A	G	4928979	3	3	21	1	0	0	0	0	1	0	0	0	11135	159	6	4	382	4	OR51A7	11	4928979	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1978778	4928979	130077537	450	1871										
FAM160A2	84067	broad.mit.edu	37	chr11	6238902	6238902	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccctcaggccatgatcctggCactccattgagctggggagg	13	13	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:6238902C>T	ENST00000265978.4	-	9	2314	c.1956G>A	c.(1954-1956)gtG>gtA	p.V652V	FAM160A2_ENST00000524416.1_Silent_p.V638V|FAM160A2_ENST00000449352.2_Silent_p.V638V	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	638					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ATGATCCTGGCACTCCATTGA	0.672													18	33					0	0	1	0	0	T	6238902	C	T	6238902	2	4	21	1	0	0	0	0	0	0	0	1	5499	697	25	3		3	FAM160A2	11	6238902	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1309923	6238902	128767614	451	1872										
TRIM3	10612	broad.mit.edu	37	chr11	6478961	6478961	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcgagctggcgctgcagggcCgccttgtgctgctccaccac	13	16	0	0	rs116462813	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:6478961C>T	ENST00000525074.1	-	4	874	c.480G>A	c.(478-480)gcG>gcA	p.A160A	TRIM3_ENST00000536344.1_Silent_p.A41A|TRIM3_ENST00000537602.1_Silent_p.A160A|TRIM3_ENST00000529058.1_5'UTR|TRIM3_ENST00000345851.3_Silent_p.A160A|TRIM3_ENST00000359518.3_Silent_p.A160A	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	160					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGCAGGGCCGCCTTGTGCT	0.687													39	61					0	0	1	0	0	T	6478961	C	T	6478961	2	4	21	1	0	0	0	0	0	0	0	1	16564	639	23	1		1	TRIM3	11	6478961	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	240059	6478961	128527555	452	1873										
ST5	6764	broad.mit.edu	37	chr11	8720914	8720914	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtagagcaaggccaccaccGcgtgggagcagctggagagg	18	10	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:8720914G>A	ENST00000534127.1	-	18	3129	c.2744C>T	c.(2743-2745)gCg>gTg	p.A915V	ST5_ENST00000526099.1_Missense_Mutation_p.A428V|ST5_ENST00000526757.1_Missense_Mutation_p.A495V|ST5_ENST00000534278.1_Missense_Mutation_p.A106V|ST5_ENST00000530438.1_Missense_Mutation_p.A495V|RPL27A_ENST00000531102.1_Intron|ST5_ENST00000313726.6_Missense_Mutation_p.A915V|ST5_ENST00000357665.1_Missense_Mutation_p.A915V|ST5_ENST00000530991.1_Missense_Mutation_p.A387V	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	915	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		GGCCACCACCGCGTGGGAGCA	0.617													30	23					0	0	1	0	0	A	8720914	G	A	8720914	3	1	21	1	0	0	0	0	1	0	0	0	15275	1087	38	1	693	1	ST5	11	8720914	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2241953	8720914	126285602	453	1874										
IPO7	10527	broad.mit.edu	37	chr11	9452491	9452491	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgatgacaaagcagttactGctatgggaattctgaataca	10	6	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:9452491G>A	ENST00000379719.3	+	16	1964	c.1822G>A	c.(1822-1824)Gct>Act	p.A608T	CTD-2371O3.2_ENST00000531111.1_RNA	NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	608					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AGCAGTTACTGCTATGGGAAT	0.363													25	27					0	0	1	0	0	A	9452491	G	A	9452491	3	1	21	1	0	0	0	0	1	0	0	0	7840	1319	46	3	1884	3	IPO7	11	9452491	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	731577	9452491	125554025	454	1875										
EIF4G2	1982	broad.mit.edu	37	chr11	10825100	10825100	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcactccaaatcctctcccAtatctttgagttggactctc	6	14	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:10825100A>G	ENST00000526148.1	-	9	1250	c.740T>C	c.(739-741)aTg>aCg	p.M247T	EIF4G2_ENST00000396525.2_Missense_Mutation_p.M247T|EIF4G2_ENST00000339995.5_Missense_Mutation_p.M247T|EIF4G2_ENST00000525681.1_Missense_Mutation_p.M247T	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	247	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ATCCTCTCCCATATCTTTGAG	0.423													29	51					0	0	1	0	0	G	10825100	A	G	10825100	3	3	21	1	0	0	0	0	1	0	0	0	5065	217	8	4	2039	4	EIF4G2	11	10825100	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1372609	10825100	124181416	455	1876										
MICAL2	9645	broad.mit.edu	37	chr11	12246317	12246317	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gacctgaccacatcctggcgCagtgggttggccctgtgtgc	14	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:12246317C>T	ENST00000256194.4	+	13	1926	c.1638C>T	c.(1636-1638)cgC>cgT	p.R546R	MICAL2_ENST00000342902.5_Silent_p.R546R|MICAL2_ENST00000379612.3_Silent_p.R546R|MICAL2_ENST00000537344.1_Silent_p.R546R|MICAL2_ENST00000527546.1_Silent_p.R546R	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	546	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CATCCTGGCGCAGTGGGTTGG	0.637													32	23					0	0	1	0	0	T	12246317	C	T	12246317	2	4	21	1	0	0	0	0	0	0	0	1	9617	697	25	3		3	MICAL2	11	12246317	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1421217	12246317	122760199	456	1877										
HPS5	11234	broad.mit.edu	37	chr11	18301454	18301454	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctgctgggaccagagaaacCgatcgcatttttcaagcatg	10	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:18301454C>T	ENST00000396253.3	-	22	3485	c.3023G>A	c.(3022-3024)cGg>cAg	p.R1008Q	HPS5_ENST00000537258.1_3'UTR|HPS5_ENST00000438420.2_Missense_Mutation_p.R1008Q|HPS5_ENST00000349215.3_Missense_Mutation_p.R1122Q	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	1122						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						CCAGAGAAACCGATCGCATTT	0.403									Hermansky-Pudlak syndrome				20	34					0	0	1	0	0	T	18301454	C	T	18301454	3	4	21	1	0	0	0	0	1	0	0	0	7382	652	23	1	28	1	HPS5	11	18301454	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6055137	18301454	116705062	457	1878										
E2F8	79733	broad.mit.edu	37	chr11	19255993	19255993	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctaggcttactatctgaggcGttgacaccaaaaacagcatc	8	11	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:19255993G>A	ENST00000527884.1	-	6	1074	c.842C>T	c.(841-843)aCg>aTg	p.T281M	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Missense_Mutation_p.T281M	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	281					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TATCTGAGGCGTTGACACCAA	0.403													82	105					0	0	1	0	0	A	19255993	G	A	19255993	3	1	21	1	0	0	0	0	1	0	0	0	4899	1145	40	1	1793	1	E2F8	11	19255993	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	954539	19255993	115750523	458	1879										
LGR4	55366	broad.mit.edu	37	chr11	27406980	27406980	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caagtccttcaaaactgtccTcggggactgaggtaatatgg	11	9	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:27406980T>C	ENST00000379214.4	-	5	880	c.437A>G	c.(436-438)gAg>gGg	p.E146G	LGR4_ENST00000389858.4_Missense_Mutation_p.E122G|LGR4_ENST00000480977.2_Missense_Mutation_p.E98G	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	146						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						AAAACTGTCCTCGGGGACTGA	0.473													22	28					0	0	1	0	0	C	27406980	T	C	27406980	3	2	21	1	0	0	0	0	1	0	0	0	8795	1551	54	4	2474	4	LGR4	11	27406980	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	8150987	27406980	107599536	459	1880										
EHF	26298	broad.mit.edu	37	chr11	34668216	34668216	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctctacagcaacttgcagCatctgaagtggaacggtgac	10	11	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:34668216C>T	ENST00000257831.3	+	3	449	c.328C>T	c.(328-330)Cat>Tat	p.H110Y	EHF_ENST00000530286.1_Missense_Mutation_p.H110Y|EHF_ENST00000531728.1_Missense_Mutation_p.H110Y|EHF_ENST00000527935.1_Missense_Mutation_p.H110Y|EHF_ENST00000531794.1_Missense_Mutation_p.H132Y|EHF_ENST00000533754.1_Missense_Mutation_p.H110Y|EHF_ENST00000450654.2_Missense_Mutation_p.H110Y	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	110	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			CAACTTGCAGCATCTGAAGTG	0.552													97	140					0	0	1	0	0	T	34668216	C	T	34668216	3	4	21	1	0	0	0	0	1	0	0	0	5007	710	25	3	334	3	EHF	11	34668216	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7261236	34668216	100338300	460	1881										
MAPK8IP1	9479	broad.mit.edu	37	chr11	45924624	45924624	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggaatatgaggaggccccgCggccccagccccctgcctgc	13	17	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:45924624C>T	ENST00000395629.2	+	5	1606	c.1276C>T	c.(1276-1278)Cgg>Tgg	p.R426W	MAPK8IP1_ENST00000241014.2_Missense_Mutation_p.R436W			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	436					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		GGAGGCCCCGCGGCCCCAGCC	0.602													18	32					0	0	1	0	0	T	45924624	C	T	45924624	3	4	21	1	0	0	0	0	1	0	0	0	9333	759	27	1	1324	1	MAPK8IP1	11	45924624	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	11256408	45924624	89081892	461	1882										
ZNF408	79797	broad.mit.edu	37	chr11	46724534	46724534	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgttactttgctttgcagCttggtacaacggggcaggct	13	9	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:46724534C>T	ENST00000311764.2	+	4	623	c.392_splice	c.e4-1	p.S131_splice		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGCTTTGCAGCTTGGTACAAC	0.577													30	39					0	0	1	0	0	T	46724534	C	T	46724534	5	4	21	1	0	0	0	0	0	0	1	0	17944	811	28	3	439	3	ZNF408	11	46724534	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	799910	46724534	88281982	462	1883										
LRP4	4038	broad.mit.edu	37	chr11	46912011	46912011	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catgctggaggcctcaatacGgggggtgttgccccagtctg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:46912011delG	ENST00000378623.1	-	14	1974	c.1732delC	c.(1732-1734)gtfs	p.R578fs		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	578					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		GCCTCAATACGGGGGGTGTTG	0.542											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	35	---	---	---	---						-	46912011	G	-	46912011	7	5	21	1	0	1	0	1	0	0	0	0	9003	1116	39	0	4085	0	LRP4	11	46912011	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	187477	46912011	88094505	463	1884										
PACSIN3	29763	broad.mit.edu	37	chr11	47200457	47200457	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctctcaccctggggaccccGgggactggggtgggggtgcg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:47200457delG	ENST00000539589.1	-	9	1367	c.1025delC	c.(1024-1026)cgfs	p.P342fs	PACSIN3_ENST00000298838.6_Frame_Shift_Del_p.P342fs	NM_001184975.1	NP_001171904.1	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in neurons 3	342					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)	11						TGGGGACCCCGGGGACTGGGG	0.602													28	62	---	---	---	---						-	47200457	G	-	47200457	7	5	21	1	0	1	0	1	0	0	0	0	11422	1116	39	0	261	0	PACSIN3	11	47200457	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	288446	47200457	87806059	464	1885										
OR4C6	219432	broad.mit.edu	37	chr11	55432816	55432816	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agtctgaggtcacctatgtaTttttttcttaccttcttgtc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:55432816delT	ENST00000314259.3	+	1	203	c.174delT	c.(172-174)tafs	p.Y58fs		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						CACCTATGTATTTTTTTCTTA	0.423													57	92	---	---	---	---						-	55432816	T	-	55432816	7	5	21	1	0	1	0	1	0	0	0	0	11099	1500	52	0	176	0	OR4C6	11	55432816	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	8232359	55432816	79573700	465	1886										
OR8H3	390152	broad.mit.edu	37	chr11	55890694	55890694	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgttttatactattgtgatTcccatgctgaatccactcat	6	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:55890694T>C	ENST00000313472.3	+	1	846	c.846T>C	c.(844-846)atT>atC	p.I282I		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					CTATTGTGATTCCCATGCTGA	0.368													46	69					0	0	1	0	0	C	55890694	T	C	55890694	2	2	21	1	0	0	0	0	0	0	0	1	11285	1771	62	4		4	OR8H3	11	55890694	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	457878	55890694	79115822	466	1887										
DTX4	23220	broad.mit.edu	37	chr11	58958609	58958609	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaaaccccagaggaagtgctAaaaaaatatctacagaaagt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:58958609delA	ENST00000227451.3	+	5	1286	c.1182delA	c.(1180-1182)ctfs	p.L394fs	DTX4_ENST00000532982.1_Frame_Shift_Del_p.L288fs|DTX4_ENST00000531902.1_3'UTR	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	394					Notch signaling pathway	cytoplasm	zinc ion binding	p.K290fs*34(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				AGGAAGTGCTAAAAAAATATC	0.502													5	5	---	---	---	---						-	58958609	A	-	58958609	7	5	21	1	0	1	0	1	0	0	0	0	4823	349	13	0	1200	0	DTX4	11	58958609	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3067915	58958609	76047907	467	1888										
SLC15A3	51296	broad.mit.edu	37	chr11	60718781	60718781	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcgccagcaggtaggaggcGcccaggaataccagcgcggc	17	13	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:60718781G>A	ENST00000227880.3	-	1	476	c.243C>T	c.(241-243)ggC>ggT	p.G81G		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	81					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GGTAGGAGGCGCCCAGGAATA	0.701													4	3					0	0	1	0	0	A	60718781	G	A	60718781	2	1	21	1	0	0	0	0	0	0	0	1	14454	1074	38	1		1	SLC15A3	11	60718781	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1760172	60718781	74287735	468	1889										
AHNAK	79026	broad.mit.edu	37	chr11	62297595	62297595	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttgggaccttttagttttgCgtctggaccttcaatattca	8	8	3	0	rs139799392		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:62297595C>T	ENST00000378024.4	-	5	4568	c.4294G>A	c.(4294-4296)Gca>Aca	p.A1432T	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1432					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTAGTTTTGCGTCTGGACCT	0.433													111	186					0	0	1	0	0	T	62297595	C	T	62297595	3	4	21	1	0	0	0	0	1	0	0	0	411	768	27	1	13498	1	AHNAK	11	62297595	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1578814	62297595	72708921	469	1890										
FLRT1	23769	broad.mit.edu	37	chr11	63884829	63884829	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccagggccctgagaaggtcCggggcatggccatcaaggac	16	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:63884829C>T	ENST00000246841.3	+	2	2133	c.1090C>T	c.(1090-1092)Cgg>Tgg	p.R364W	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	336					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						TGAGAAGGTCCGGGGCATGGC	0.657													43	53					0	0	1	0	0	T	63884829	C	T	63884829	3	4	21	1	0	0	0	0	1	0	0	0	5970	643	23	1	1092	1	FLRT1	11	63884829	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1587234	63884829	71121687	470	1891										
EHBP1L1	254102	broad.mit.edu	37	chr11	65351790	65351790	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccactggctaccgtggcgtcCgcatcaccaacttcaccaca	7	18	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:65351790C>T	ENST00000309295.4	+	10	3437	c.3172C>T	c.(3172-3174)Cgc>Tgc	p.R1058C		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	1058	CH.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						CCGTGGCGTCCGCATCACCAA	0.627													70	95					0	0	1	0	0	T	65351790	C	T	65351790	3	4	21	1	0	0	0	0	1	0	0	0	5002	652	23	1	3210	1	EHBP1L1	11	65351790	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1466961	65351790	69654726	471	1892										
PCNXL3	399909	broad.mit.edu	37	chr11	65402797	65402797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgagggtgacccagcatggCgcagcgccatcctcagcaac	12	14	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:65402797C>T	ENST00000355703.3	+	31	5601	c.5062C>T	c.(5062-5064)Cgc>Tgc	p.R1688C		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1688						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CCCAGCATGGCGCAGCGCCAT	0.612													12	7					0	0	1	0	0	T	65402797	C	T	65402797	3	4	21	1	0	0	0	0	1	0	0	0	11639	768	27	1	5184	1	PCNXL3	11	65402797	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	51007	65402797	69603719	472	1893										
B3GNT1	11041	broad.mit.edu	37	chr11	66114163	66114163	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acaacccataatagaagggcCgcacctcgccaacctggtag	9	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:66114163C>A	ENST00000311181.4	-	1	1000	c.854G>T	c.(853-855)cGg>cTg	p.R285L		NM_006876.2	NP_006867.1	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	285					poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(1)	12						ATAGAAGGGCCGCACCTCGCC	0.632													52	58					3.76525e-18	4.10201e-18	1	1	0	A	66114163	C	A	66114163	3	1	21	1	0	0	0	0	1	0	0	0	1254	652	23	5	401	5	B3GNT1	11	66114163	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	711366	66114163	68892353	473	1894										
PELI3	246330	broad.mit.edu	37	chr11	66241352	66241352	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctcggtctgtgggaatgtgTacacattgcgggacagccgc	14	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:66241352T>C	ENST00000349459.6	+	6	1008	c.724T>C	c.(724-726)Tac>Cac	p.Y242H	PELI3_ENST00000524466.1_Missense_Mutation_p.Y266H|PELI3_ENST00000531856.1_Intron|CTD-3074O7.5_ENST00000527092.1_RNA|PELI3_ENST00000320740.7_Missense_Mutation_p.Y266H	NM_001098510.1	NP_001091980.1	Q8N2H9	PELI3_HUMAN	pellino E3 ubiquitin protein ligase family member 3	266						cytosol	protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	15						TGGGAATGTGTACACATTGCG	0.652													9	110					0	0	1	0	0	C	66241352	T	C	66241352	3	2	21	1	0	0	0	0	1	0	0	0	11769	1638	57	4	818	4	PELI3	11	66241352	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	127189	66241352	68765164	474	1895										
PITPNM1	9600	broad.mit.edu	37	chr11	67261432	67261432	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtagacaccaatgcccagcGcgcgttctgggggaactggg	16	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:67261432G>A	ENST00000356404.3	-	20	3194	c.2969C>T	c.(2968-2970)gCg>gTg	p.A990V	PITPNM1_ENST00000534749.1_Missense_Mutation_p.A990V|PITPNM1_ENST00000436757.2_Missense_Mutation_p.A989V|PITPNM1_ENST00000526450.1_5'UTR	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	990					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						AATGCCCAGCGCGCGTTCTGG	0.682													28	21					0	0	1	0	0	A	67261432	G	A	67261432	3	1	21	1	0	0	0	0	1	0	0	0	11997	1087	38	1	785	1	PITPNM1	11	67261432	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1020080	67261432	67745084	475	1896										
ALDH3B1	221	broad.mit.edu	37	chr11	67790205	67790205	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgggagaagcccctggccctGtacgccttctccaacagcag	11	16	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:67790205G>A	ENST00000539229.1	+	10	1202	c.1086G>A	c.(1084-1086)ctG>ctA	p.L362L	ALDH3B1_ENST00000316367.6_Intron|ALDH3B1_ENST00000342456.6_Silent_p.L326L|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000007633.8_Silent_p.L362L	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	364					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	CCCTGGCCCTGTACGCCTTCT	0.677													57	56					0	0	1	0	0	A	67790205	G	A	67790205	2	1	21	1	0	0	0	0	0	0	0	1	496	1364	48	3		3	ALDH3B1	11	67790205	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	528773	67790205	67216311	476	1897										
CCND1	595	broad.mit.edu	37	chr11	69466022	69466022	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtggacctggcttgcacacCcaccgacgtgcgggacgtgg	16	13	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:69466022C>T	ENST00000227507.2	+	5	1087	c.860C>T	c.(859-861)cCc>cTc	p.P287L		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	287					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding	p.P287L(1)|p.P287H(1)		NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	GCTTGCACACCCACCGACGTG	0.716			T	"IGH@, FSTL3"	"CLL, B-ALL, breast"					Multiple Myeloma(6;0.086)			10	13					0	0	1	0	0	T	69466022	C	T	69466022	3	4	21	1	0	0	0	0	1	0	0	0	2938	623	22	3	878	3	CCND1	11	69466022	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1675817	69466022	65540494	477	1898										
INPPL1	3636	broad.mit.edu	37	chr11	71948748	71948748	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caggccccctggagctgcagCccccccggggactgccctcg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:71948748delC	ENST00000541756.1	+	26	3664	c.2734delC	c.(2734-2736)ccfs	p.P913fs	INPPL1_ENST00000298229.2_Frame_Shift_Del_p.P1155fs|INPPL1_ENST00000538751.1_Frame_Shift_Del_p.P913fs			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1155					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GGAGCTGCAGCCCCCCCGGGG	0.697													12	35	---	---	---	---						-	71948748	C	-	71948748	7	5	21	1	0	1	0	1	0	0	0	0	7804	739	26	0	3562	0	INPPL1	11	71948748	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2482726	71948748	63057768	478	1899	9	2								
INPPL1	3636	broad.mit.edu	37	chr11	71948755	71948755	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctggagctgcagcccccccGgggactgccctcggactatg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:71948755delG	ENST00000541756.1	+	26	3671	c.2741delG	c.(2740-2742)cgfs	p.R914fs	INPPL1_ENST00000298229.2_Frame_Shift_Del_p.R1156fs|INPPL1_ENST00000538751.1_Frame_Shift_Del_p.R914fs			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1156					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CAGCCCCCCCGGGGACTGCCC	0.697													16	29	---	---	---	---						-	71948755	G	-	71948755	7	5	21	1	0	1	0	1	0	0	0	0	7804	1116	39	0	3569	0	INPPL1	11	71948755	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7	71948755	63057761	479	1900	9	2								
RNF169	254225	broad.mit.edu	37	chr11	74547475	74547475	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aatggtgttctagttgagagCctaagtgaagagccacttcc	11	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:74547475C>G	ENST00000299563.4	+	6	1840	c.1827C>G	c.(1825-1827)agC>agG	p.S609R		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	609							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						TAGTTGAGAGCCTAAGTGAAG	0.423													35	65					0	0	1	0	0	G	74547475	C	G	74547475	3	3	21	1	0	0	0	0	1	0	0	0	13511	738	26	5	1849	5	RNF169	11	74547475	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2598720	74547475	60459041	480	1901										
XRRA1	143570	broad.mit.edu	37	chr11	74554923	74554923	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggagcctctgtaatgttccGgggatcccgcaagcgaatga							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:74554923delG	ENST00000340360.6	-	18	2432	c.2101delC	c.(2101-2103)ggfs	p.R701fs	XRRA1_ENST00000321448.8_Frame_Shift_Del_p.R426fs|XRRA1_ENST00000527087.1_Intron	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	701					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						GTAATGTTCCGGGGATCCCGC	0.557													11	14	---	---	---	---						-	74554923	G	-	74554923	7	5	21	1	0	1	0	1	0	0	0	0	17520	1115	39	0	285	0	XRRA1	11	74554923	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7448	74554923	60451593	481	1902										
GRM5	2915	broad.mit.edu	37	chr11	88386450	88386450	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcggtggtttgtttctggccGgagcttcagataataatcat	11	7	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:88386450G>A	ENST00000418177.2	-	4	1400	c.1033C>T	c.(1033-1035)Cgg>Tgg	p.R345W	GRM5_ENST00000455756.2_Missense_Mutation_p.R345W|GRM5_ENST00000305432.5_Missense_Mutation_p.R345W|GRM5_ENST00000393297.1_Missense_Mutation_p.R345W|GRM5_ENST00000305447.4_Missense_Mutation_p.R345W			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	345					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GTTTCTGGCCGGAGCTTCAGA	0.458													46	47					0	0	1	0	0	A	88386450	G	A	88386450	3	1	21	1	0	0	0	0	1	0	0	0	6840	1115	39	1	2633	1	GRM5	11	88386450	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	13831527	88386450	46620066	482	1903										
FOLH1B	219595	broad.mit.edu	37	chr11	89403521	89403522	+	RNA	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgttaaccagttttgttttgINSttttttttcaaagaatgtct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:89403521_89403522insT	ENST00000532352.1	+	0	908							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GTTTTGTTTTGTTTTTTTTCAA	0.332													9	20	---	---	---	---						T	89403522	-	T	89403521	6	5	21	0	1	1	1	0	0	0	0	0	6012	1392	48	0		0	FOLH1B	11	89403521	RNA	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	1017071	89403521	45602995	483	1904										
FAT3	120114	broad.mit.edu	37	chr11	92624210	92624210	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccatgagtgactacgagagCgtgggagagctcagcctcgc	15	11	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:92624210C>T	ENST00000298047.6	+	27	13718	c.13701C>T	c.(13699-13701)agC>agT	p.S4567S	FAT3_ENST00000409404.2_Silent_p.S4535S|FAT3_ENST00000525166.1_Silent_p.S4417S|FAT3_ENST00000533797.1_Silent_p.S870S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4567					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACTACGAGAGCGTGGGAGAGC	0.527										TCGA Ovarian(4;0.039)			8	14					0	0	1	0	0	T	92624210	C	T	92624210	2	4	21	1	0	0	0	0	0	0	0	1	5723	767	27	1		1	FAT3	11	92624210	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3220689	92624210	42382306	484	1905										
CEP57	9702	broad.mit.edu	37	chr11	95552024	95552026	+	In_Frame_Del	DEL	GAA	GAA	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agttggaagcaaaactccatGaagaagaacaggaaaggaaa					rs142615007		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:95552024_95552026delGAA	ENST00000325542.5	+	6	893_895	c.655_657delGAA	c.(655-657)del	p.E221del	CEP57_ENST00000537677.1_In_Frame_Del_p.E194del|CEP57_ENST00000325486.5_In_Frame_Del_p.E221del|CEP57_ENST00000541150.1_In_Frame_Del_p.E212del|CEP57_ENST00000538658.1_In_Frame_Del_p.E221del	NM_001243776.1|NM_014679.4	NP_001230705.1|NP_055494.2	Q86XR8	CEP57_HUMAN	centrosomal protein 57kDa	221	centrosome localization domain (CLD) (By similarity).				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AAAACTCCATGAAGAAGAACAGG	0.345									Mosaic Variegated Aneuploidy Syndrome				23	37	---	---	---	---						-	95552026	GAA	-	95552024	7	5	21	1	0	1	0	1	0	0	0	0	3278	1291	45	0	677	0	CEP57	11	95552024	In_Frame_Del	DEL	GAA	TCGA-N7-A4Y0-01A-12D-A28R-08	2927814	95552024	39454492	485	1906										
ATM	472	broad.mit.edu	37	chr11	108165727	108165727	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acttgaaggactaaaggatcTtcgaagacaactggaactac	9	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:108165727T>G	ENST00000278616.4	+	32	5235	c.4850T>G	c.(4849-4851)cTt>cGt	p.L1617R	ATM_ENST00000452508.2_Missense_Mutation_p.L1617R	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1617					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.E1612_Q1620>*(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CTAAAGGATCTTCGAAGACAA	0.358			"D, Mis, N, F, S"		T-PLL	"leukemia, lymphoma, medulloblastoma, glioma"		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			45	69					0	0	1	0	0	G	108165727	T	G	108165727	3	3	21	1	0	0	0	0	1	0	0	0	1108	1609	56	4	4972	4	ATM	11	108165727	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	12613703	108165727	26840789	486	1907										
C11orf65	160140	broad.mit.edu	37	chr11	108332220	108332220	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actcacaaggaaacttttccAggcctgctgaatgactctgg	9	11	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:108332220A>G	ENST00000525729.1	-	2	136	c.67T>C	c.(67-69)Tgg>Cgg	p.W23R	C11orf65_ENST00000393084.1_Missense_Mutation_p.W23R|C11orf65_ENST00000529391.1_Missense_Mutation_p.W23R			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	23										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		AAACTTTTCCAGGCCTGCTGA	0.308													63	83					0	0	1	0	0	G	108332220	A	G	108332220	3	3	21	1	0	0	0	0	1	0	0	0	1660	188	7	4	906	4	C11orf65	11	108332220	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	166493	108332220	26674296	487	1908										
APOA5	0	broad.mit.edu	37	chr11	116661100	116661100	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaaagcctgaagtcgctggCgcacctcctcggagagcatc	13	13	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:116661100C>T	ENST00000542499.1	-	4	917	c.845G>A	c.(844-846)cGc>cAc	p.R282H	APOA5_ENST00000227665.4_Missense_Mutation_p.R282H	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	282					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		AAGTCGCTGGCGCACCTCCTC	0.652													50	75					0	0	1	0	0	T	116661100	C	T	116661100	3	4	21	1	0	0	0	0	1	0	0	0	781	768	27	1	259	1	APOA5	11	116661100	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	8328880	116661100	18345416	488	1909										
TMPRSS13	84000	broad.mit.edu	37	chr11	117779388	117779388	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcatagtcgtcctcctcatcGgtgtaattgctgttgatgat	9	9	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:117779388G>A	ENST00000528626.1	-	8	1189	c.1116C>T	c.(1114-1116)acC>acT	p.T372T	TMPRSS13_ENST00000526090.1_Silent_p.T407T|TMPRSS13_ENST00000524993.1_Silent_p.T407T|TMPRSS13_ENST00000445164.2_Silent_p.T407T|TMPRSS13_ENST00000430170.2_Silent_p.T407T	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	402	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		CCTCCTCATCGGTGTAATTGC	0.617													11	5					0	0	1	0	0	A	117779388	G	A	117779388	2	1	21	1	0	0	0	0	0	0	0	1	16304	1103	39	1		1	TMPRSS13	11	117779388	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1118288	117779388	17227128	489	1910										
NLRX1	79671	broad.mit.edu	37	chr11	119044561	119044561	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atccccttctcctgtgaggaCctgtcatccctgggccctgc	9	17	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:119044561C>T	ENST00000409109.1	+	5	1190	c.603C>T	c.(601-603)gaC>gaT	p.D201D	NLRX1_ENST00000292199.2_Silent_p.D201D|NLRX1_ENST00000409991.1_Silent_p.D201D|NLRX1_ENST00000525863.1_Silent_p.D201D|NLRX1_ENST00000409265.4_Silent_p.D201D			Q86UT6	NLRX1_HUMAN	NLR family member X1	201	NACHT.|Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CCTGTGAGGACCTGTCATCCC	0.647													26	45					0	0	1	0	0	T	119044561	C	T	119044561	2	4	21	1	0	0	0	0	0	0	0	1	10531	506	18	3		3	NLRX1	11	119044561	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1265173	119044561	15961955	490	1911										
OAF	220323	broad.mit.edu	37	chr11	120097673	120097673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtggatgccatctacacccGccaggaggatgtccggttct	12	13	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:120097673G>A	ENST00000328965.4	+	3	1028	c.515G>A	c.(514-516)cGc>cAc	p.R172H	OAF_ENST00000531220.1_Missense_Mutation_p.R56H	NM_178507.2	NP_848602.1	Q86UD1	OAF_HUMAN	OAF homolog (Drosophila)	172										kidney(1)|lung(5)	6		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		ATCTACACCCGCCAGGAGGAT	0.647													27	24					0	0	1	0	0	A	120097673	G	A	120097673	3	1	21	1	0	0	0	0	1	0	0	0	10845	1087	38	1	525	1	OAF	11	120097673	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1053112	120097673	14908843	491	1912										
TECTA	7007	broad.mit.edu	37	chr11	120983885	120983885	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggacggcgagtggcggcgaCcccctgacaggtcttggtgg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:120983885delC	ENST00000392793.1	+	5	862	c.591delC	c.(589-591)gafs	p.D197fs	TECTA_ENST00000264037.2_Frame_Shift_Del_p.D197fs			O75443	TECTA_HUMAN	tectorin alpha	197	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GTGGCGGCGACCCCCTGACAG	0.582											OREG0021430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	75	---	---	---	---						-	120983885	C	-	120983885	7	5	21	1	0	1	0	1	0	0	0	0	15805	506	18	0	605	0	TECTA	11	120983885	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	886212	120983885	14022631	492	1913										
EI24	9538	broad.mit.edu	37	chr11	125453541	125453541	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaagttcccttcaccgcatcCgtcgcctgccaaactgaagg	9	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:125453541C>T	ENST00000278903.6	+	12	1225	c.983C>T	c.(982-984)cCg>cTg	p.P328L	EI24_ENST00000530985.1_3'UTR|STT3A-AS1_ENST00000530526.1_RNA|STT3A-AS1_ENST00000532714.1_RNA|EI24_ENST00000343678.4_3'UTR	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	329					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TCACCGCATCCGTCGCCTGCC	0.547													14	9					0	0	1	0	0	T	125453541	C	T	125453541	3	4	21	1	0	0	0	0	1	0	0	0	5011	652	23	1	1023	1	EI24	11	125453541	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4469656	125453541	9552975	493	1914										
ARHGAP32	9743	broad.mit.edu	37	chr11	128843210	128843210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagttgaggcttgctgtgcgGactcagctaatgctagcgcc	14	10	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:128843210G>A	ENST00000310343.9	-	21	3148	c.3149C>T	c.(3148-3150)tCc>tTc	p.S1050F	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.S701F|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.S701F	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1050					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TTGCTGTGCGGACTCAGCTAA	0.512													79	114					0	0	1	0	0	A	128843210	G	A	128843210	3	1	21	1	0	0	0	0	1	0	0	0	878	1174	41	3	3122	3	ARHGAP32	11	128843210	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3389669	128843210	6163306	494	1915										
OPCML	4978	broad.mit.edu	37	chr11	132306088	132306088	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaaagtcagagtggacatgcGgcctttgttttcaatcctca	10	9	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:132306088G>A	ENST00000331898.7	-	6	1407	c.829C>T	c.(829-831)Cgc>Tgc	p.R277C	OPCML_ENST00000524381.1_Missense_Mutation_p.R270C|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000541867.1_Missense_Mutation_p.R277C|OPCML_ENST00000374778.4_Missense_Mutation_p.R236C	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	277	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GTGGACATGCGGCCTTTGTTT	0.463													29	62					0	0	1	0	0	A	132306088	G	A	132306088	3	1	21	1	0	0	0	0	1	0	0	0	10921	1116	39	1	216	1	OPCML	11	132306088	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3462878	132306088	2700428	495	1916										
WNT5B	81029	broad.mit.edu	37	chr12	1748922	1748922	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgccatcagccgggcctgccGcgagggcgagctctccacct	13	18	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:1748922G>A	ENST00000397196.2	+	4	633	c.401G>A	c.(400-402)cGc>cAc	p.R134H	WNT5B_ENST00000310594.3_Missense_Mutation_p.R134H|WNT5B_ENST00000542408.1_Intron|WNT5B_ENST00000537031.1_Missense_Mutation_p.R134H	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	134				R -> S (in Ref. 1; AAG38659).	angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CGGGCCTGCCGCGAGGGCGAG	0.731													4	15					0	0	1	0	0	A	1748922	G	A	1748922	3	1	21	1	0	0	0	0	1	0	0	0	17451	1087	38	1	411	1	WNT5B	12	1748922	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08		1748922	132102973	496	1917										
CACNA1C	775	broad.mit.edu	37	chr12	2614074	2614074	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cactaatcatcatagggtcaTtttttgtacttaacttggtt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:2614074delT	ENST00000399655.1	+	8	1445	c.1180delT	c.(1180-1182)ttfs	p.F395fs	CACNA1C_ENST00000399621.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399595.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399591.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399638.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000402845.3_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000480911.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000347598.4_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399644.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399601.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399629.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000491104.1_Intron|CACNA1C_ENST00000399597.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000335762.5_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000327702.7_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000344100.3_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000399649.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399606.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399637.1_Frame_Shift_Del_p.F395fs	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	395					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATAGGGTCATTTTTTGTACT	0.403													18	26	---	---	---	---						-	2614074	T	-	2614074	7	5	21	1	0	1	0	1	0	0	0	0	2558	1493	52	0	1318	0	CACNA1C	12	2614074	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	865152	2614074	131237821	497	1918										
TSPAN9	10867	broad.mit.edu	37	chr12	3392257	3392257	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcttccagcacatccaccGgactggtaagaagtacgacg	9	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:3392257G>A	ENST00000011898.5	+	9	856	c.695G>A	c.(694-696)cGg>cAg	p.R232Q	TSPAN9_ENST00000537971.1_Missense_Mutation_p.R232Q	NM_006675.4	NP_006666.1	O75954	TSN9_HUMAN	tetraspanin 9	232						integral to plasma membrane|membrane fraction				endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			CACATCCACCGGACTGGTAAG	0.637													4	106					0	0	1	0	0	A	3392257	G	A	3392257	3	1	21	1	0	0	0	0	1	0	0	0	16714	1116	39	1	721	1	TSPAN9	12	3392257	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	778183	3392257	130459638	498	1919										
CHD4	1108	broad.mit.edu	37	chr12	6703716	6703716	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggtgtcagtgccctgagccCaggagaagcgcaaccaattc	12	12	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:6703716C>T	ENST00000309577.6	-	15	2385	c.2222G>A	c.(2221-2223)tGg>tAg	p.W741*	CHD4_ENST00000357008.2_Nonsense_Mutation_p.W741*|CHD4_ENST00000544484.1_Nonsense_Mutation_p.W738*|CHD4_ENST00000544040.1_Nonsense_Mutation_p.W734*			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	741	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCCTGAGCCCAGGAGAAGCG	0.522													43	56					0	0	1	0	0	T	6703716	C	T	6703716	4	4	21	1	0	0	0	0	0	1	0	0	3349	595	21	3	3620	3	CHD4	12	6703716	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3311459	6703716	127148179	499	1920										
LPCAT3	10162	broad.mit.edu	37	chr12	7090985	7090985	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cactcaccaatcagcttcaaAgtcagaacacaatgtggcat	6	12	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:7090985A>T	ENST00000261407.4	-	4	532	c.447T>A	c.(445-447)acT>acA	p.T149T	U47924.19_ENST00000564245.1_RNA	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	149					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						TCAGCTTCAAAGTCAGAACAC	0.522													5	81					0	0	1	0	0	T	7090985	A	T	7090985	2	4	21	1	0	0	0	0	0	0	0	1	8956	59	3	4		4	LPCAT3	12	7090985	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	387269	7090985	126760910	500	1921										
CLSTN3	9746	broad.mit.edu	37	chr12	7301617	7301617	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccctgaagtggagggctacGtggtcgtccttcagcctgac	13	12	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:7301617G>A	ENST00000537408.1	+	12	2471	c.1933G>A	c.(1933-1935)Gtg>Atg	p.V645M	CLSTN3_ENST00000266546.6_Missense_Mutation_p.V633M			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	633					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GGAGGGCTACGTGGTCGTCCT	0.587													19	34					0	0	1	0	0	A	7301617	G	A	7301617	3	1	21	1	0	0	0	0	1	0	0	0	3586	1145	40	1	1947	1	CLSTN3	12	7301617	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	210632	7301617	126550278	501	1922										
LRP6	4040	broad.mit.edu	37	chr12	12334194	12334194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agatccatctataaatgaacGgcgtatggccctcacttcat	7	11	3	2	rs148238873		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:12334194G>A	ENST00000261349.4	-	6	1232	c.1156C>T	c.(1156-1158)Cgt>Tgt	p.R386C	LRP6_ENST00000543091.1_Missense_Mutation_p.R386C	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	386	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				ATAAATGAACGGCGTATGGCC	0.463													65	94					0	0	1	0	0	A	12334194	G	A	12334194	3	1	21	1	0	0	0	0	1	0	0	0	9006	1116	39	1	3757	1	LRP6	12	12334194	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5032577	12334194	121517701	502	1923										
MANSC1	54682	broad.mit.edu	37	chr12	12483294	12483294	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggttggagatttctgtaaaCggtatggtttctaagctgcc	12	6	2	1	rs146158847	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:12483294C>T	ENST00000535902.1	-	4	1526	c.963G>A	c.(961-963)ccG>ccA	p.P321P	MANSC1_ENST00000545735.1_Silent_p.P240P|MANSC1_ENST00000396349.3_Silent_p.P287P			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	321	Thr-rich.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TTTCTGTAAACGGTATGGTTT	0.458													44	87					0	0	1	0	0	T	12483294	C	T	12483294	2	4	21	1	0	0	0	0	0	0	0	1	9273	523	19	1		1	MANSC1	12	12483294	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	149100	12483294	121368601	503	1924										
GPRC5A	0	broad.mit.edu	37	chr12	13061187	13061187	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttttctgcaggtccagaatgGctacaacagtccctgatggt	10	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:13061187G>A	ENST00000014914.5	+	2	894	c.4G>A	c.(4-6)Gct>Act	p.A2T	GPRC5A_ENST00000542056.1_Intron	NM_003979.3	NP_003970.1	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5, member A	2						cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	18		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	GTCCAGAATGGCTACAACAGT	0.473													23	25					0	0	1	0	0	A	13061187	G	A	13061187	3	1	21	1	0	0	0	0	1	0	0	0	6764	1203	42	3	6	3	GPRC5A	12	13061187	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	577893	13061187	120790708	504	1925										
PIK3C2G	5288	broad.mit.edu	37	chr12	18499635	18499635	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctaccagctaatcaatgtctActgtaacagcttttatgcag	6	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:18499635A>G	ENST00000433979.1	+	11	1606	c.1490A>G	c.(1489-1491)tAc>tGc	p.Y497C	PIK3C2G_ENST00000535651.1_Missense_Mutation_p.Y497C|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.Y497C|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.Y497C	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	497					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ATCAATGTCTACTGTAACAGC	0.423													21	46					0	0	1	0	0	G	18499635	A	G	18499635	3	3	21	1	0	0	0	0	1	0	0	0	11958	391	14	4	1528	4	PIK3C2G	12	18499635	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	5438448	18499635	115352260	505	1926										
PLEKHA5	54477	broad.mit.edu	37	chr12	19427544	19427545	+	Frame_Shift_Ins	INS	-	-	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accagagatccaaaacaatcINSaaaaaaacaaggaaatgagc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:19427544_19427545insA	ENST00000538714.1	+	10	926_927	c.922_923insA	c.(922-924)aaafs	p.K308fs	PLEKHA5_ENST00000317589.4_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000355397.3_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000299275.6_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000543806.1_Frame_Shift_Ins_p.K200fs|PLEKHA5_ENST00000510738.2_3'UTR|PLEKHA5_ENST00000424268.1_Frame_Shift_Ins_p.K200fs|PLEKHA5_ENST00000429027.2_Frame_Shift_Ins_p.K314fs|PLEKHA5_ENST00000359180.3_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000309364.4_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000539256.1_Frame_Shift_Ins_p.K66fs	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	308							1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					CCAAAACAATCAAAAAAACAAG	0.327													23	29	---	---	---	---						A	19427545	-	A	19427544	7	5	21	1	0	1	1	0	0	0	0	0	12106	827	29	0	960	0	PLEKHA5	12	19427544	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	927909	19427544	114424351	506	1927										
SLCO1C1	53919	broad.mit.edu	37	chr12	20864412	20864412	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagtcaattaccagtttcagTtatggaaaaatcaaaatcca	5	8	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:20864412T>C	ENST00000381552.1	+	5	865	c.497T>C	c.(496-498)gTt>gCt	p.V166A	SLCO1C1_ENST00000545102.1_Missense_Mutation_p.V48A|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.V166A|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.V166A|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.V166A			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	166					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CCAGTTTCAGTTATGGAAAAA	0.343													24	40					0	0	1	0	0	C	20864412	T	C	20864412	3	2	21	1	0	0	0	0	1	0	0	0	14779	1725	60	4	511	4	SLCO1C1	12	20864412	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1436868	20864412	112987483	507	1928										
KIF21A	55605	broad.mit.edu	37	chr12	39745622	39745623	+	Frame_Shift_Ins	INS	-	-	T													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttttcaacttctctaaatcINStttttttgctaggtctataa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:39745622_39745623insT	ENST00000395670.3	-	11	2048_2049	c.1629_1630insA	c.(1627-1632)aaatttfs	p.F544fs	KIF21A_ENST00000541463.2_Frame_Shift_Ins_p.F544fs|KIF21A_ENST00000544797.2_Frame_Shift_Ins_p.F544fs|KIF21A_ENST00000361961.3_Frame_Shift_Ins_p.F544fs|KIF21A_ENST00000361418.5_Frame_Shift_Ins_p.F544fs			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	544					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TTCTCTAAATCTTTTTTTGCTA	0.337													32	44	---	---	---	---						T	39745623	-	T	39745622	7	5	21	1	0	1	1	0	0	0	0	0	8329	913	32	0	3506	0	KIF21A	12	39745622	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	18881210	39745622	94106273	508	1929										
PUS7L	83448	broad.mit.edu	37	chr12	44139886	44139886	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttccataattctctccctcAggtttgcagaatcatttatt	4	11	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:44139886A>G	ENST00000416848.2	-	4	1714	c.1226T>C	c.(1225-1227)cTg>cCg	p.L409P	PUS7L_ENST00000431332.3_Missense_Mutation_p.L96P|PUS7L_ENST00000344862.5_Missense_Mutation_p.L409P|PUS7L_ENST00000551923.1_Missense_Mutation_p.L409P	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	409					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TCTCTCCCTCAGGTTTGCAGA	0.338													6	13					0	0	1	0	0	G	44139886	A	G	44139886	3	3	21	1	0	0	0	0	1	0	0	0	12885	188	7	4	903	4	PUS7L	12	44139886	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4394264	44139886	89712009	509	1930										
HDAC7	51564	broad.mit.edu	37	chr12	48181527	48181527	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggtactcaggatcccccatGggggggtccagacctccagc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:48181527delG	ENST00000080059.7	-	21	2420	c.2421delC	c.(2419-2421)ccfs	p.P807fs	HDAC7_ENST00000354334.3_Frame_Shift_Del_p.P770fs|HDAC7_ENST00000427332.2_Frame_Shift_Del_p.P768fs|HDAC7_ENST00000380610.4_Frame_Shift_Del_p.P824fs|HDAC7_ENST00000552960.1_Frame_Shift_Del_p.P790fs	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	768	Histone deacetylase.				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GATCCCCCATGGGGGGGTCCA	0.622													11	9	---	---	---	---						-	48181527	G	-	48181527	7	5	21	1	0	1	0	1	0	0	0	0	7052	1335	47	0	578	0	HDAC7	12	48181527	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4041641	48181527	85670368	510	1931										
ADCY6	112	broad.mit.edu	37	chr12	49176478	49176478	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaggagcgtgtaggcgatgTagacaaagaacacagggcac	16	7	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49176478T>C	ENST00000307885.4	-	1	1434	c.740A>G	c.(739-741)tAc>tGc	p.Y247C	ADCY6_ENST00000550422.1_Missense_Mutation_p.Y247C|ADCY6_ENST00000357869.3_Missense_Mutation_p.Y247C	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	247					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GTAGGCGATGTAGACAAAGAA	0.662													5	13					0	0	1	0	0	C	49176478	T	C	49176478	3	2	21	1	0	0	0	0	1	0	0	0	297	1638	57	4	2850	4	ADCY6	12	49176478	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	994951	49176478	84675417	511	1932										
DDN	23109	broad.mit.edu	37	chr12	49392006	49392006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcggccggtcccagcggcgtCgtggggcggtcccggcagaa	19	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49392006C>T	ENST00000421952.2	-	2	674	c.653G>A	c.(652-654)cGa>cAa	p.R218Q		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	218	Interaction with MAGI2.					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						CCAGCGGCGTCGTGGGGCGGT	0.716													27	40					0	0	1	0	0	T	49392006	C	T	49392006	3	4	21	1	0	0	0	0	1	0	0	0	4356	884	31	1	1486	1	DDN	12	49392006	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	215528	49392006	84459889	512	1933										
SCN8A	6334	broad.mit.edu	37	chr12	52200125	52200125	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccaaccctattccgagtcAtccgattggcccgtattggg	9	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:52200125A>G	ENST00000354534.5	+	27	5033	c.4855A>G	c.(4855-4857)Atc>Gtc	p.I1619V	SCN8A_ENST00000545061.1_Missense_Mutation_p.I1578V	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1619					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ATTCCGAGTCATCCGATTGGC	0.458													88	116					0	0	1	0	0	G	52200125	A	G	52200125	3	3	21	1	0	0	0	0	1	0	0	0	13977	217	8	4	4957	4	SCN8A	12	52200125	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2808119	52200125	81651770	513	1934										
NR4A1	0	broad.mit.edu	37	chr12	52451181	52451181	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcttctgctcaggcctggtGctacaccggctgcagtgtgc	12	13	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:52451181G>A	ENST00000545748.1	+	7	2564	c.1569G>A	c.(1567-1569)gtG>gtA	p.V523V	NR4A1_ENST00000550082.1_Silent_p.V482V|NR4A1_ENST00000394825.1_Silent_p.V469V|NR4A1_ENST00000394824.2_Silent_p.V469V|NR4A1_ENST00000243050.1_Silent_p.V469V|NR4A1_ENST00000360284.3_Silent_p.V482V			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	469					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CAGGCCTGGTGCTACACCGGC	0.602													30	49					0	0	1	0	0	A	52451181	G	A	52451181	2	1	21	1	0	0	0	0	0	0	0	1	10679	1306	46	3		3	NR4A1	12	52451181	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	251056	52451181	81400714	514	1935										
KRT76	51350	broad.mit.edu	37	chr12	53162616	53162616	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggatgctgccagagctggAgcccattccactgtggctca	12	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:53162616A>T	ENST00000332411.2	-	9	1851	c.1798T>A	c.(1798-1800)Tcc>Acc	p.S600T		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	600	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCAGAGCTGGAGCCCATTCCA	0.622													25	47					0	0	1	0	0	T	53162616	A	T	53162616	3	4	21	1	0	0	0	0	1	0	0	0	8531	304	11	4	122	4	KRT76	12	53162616	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	711435	53162616	80689279	515	1936										
KRT4	3851	broad.mit.edu	37	chr12	53202570	53202570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgctgtccaggtccaggttgCggttgttgtccatggaaagg	15	8	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:53202570C>T	ENST00000293774.4	-	5	1391	c.1121G>A	c.(1120-1122)cGc>cAc	p.R374H	KRT4_ENST00000458244.2_Missense_Mutation_p.R280H|KRT4_ENST00000551956.1_Missense_Mutation_p.R300H			B4DRS2	B4DRS2_HUMAN	keratin 4	300						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GTCCAGGTTGCGGTTGTTGTC	0.592													31	47					0	0	1	0	0	T	53202570	C	T	53202570	3	4	21	1	0	0	0	0	1	0	0	0	8519	768	27	1	683	1	KRT4	12	53202570	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	39954	53202570	80649325	516	1937										
RNF41	10193	broad.mit.edu	37	chr12	56600292	56600293	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggctcttgcaccatgtcatINScccccatgtgctggttctca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:56600292_56600293insC	ENST00000345093.4	-	7	1261_1262	c.892_893insG	c.(892-894)tgafs	p.*298fs	RNF41_ENST00000394013.2_Frame_Shift_Ins_p.*227fs|RNF41_ENST00000552656.1_Frame_Shift_Ins_p.*298fs	NM_005785.3|NM_194359.2	NP_005776.1|NP_919340.1	Q9H4P4	RNF41_HUMAN	ring finger protein 41	298					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	11						CACCATGTCATCCCCCATGTGC	0.515											OREG0021921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	128	143	---	---	---	---						C	56600293	-	C	56600292	7	5	21	1	0	1	1	0	0	0	0	0	13545	1435	50	0	64	0	RNF41	12	56600292	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	3397722	56600292	77251603	517	1938										
TSPAN31	0	broad.mit.edu	37	chr12	58139606	58139606	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccagcatccacatcatcggcGgagtcattgctgtgggagtc	12	12	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:58139606G>A	ENST00000547992.1	+	2	274	c.142G>A	c.(142-144)Gga>Aga	p.G48R	TSPAN31_ENST00000553221.1_3'UTR|TSPAN31_ENST00000257910.3_Missense_Mutation_p.G48R|TSPAN31_ENST00000547472.1_Intron			Q12999	TSN31_HUMAN	tetraspanin 31	48					positive regulation of cell proliferation	integral to plasma membrane|membrane fraction				endometrium(1)|kidney(1)|lung(5)	7	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CATCATCGGCGGAGTCATTGC	0.552													33	95					0	0	1	0	0	A	58139606	G	A	58139606	3	1	21	1	0	0	0	0	1	0	0	0	16706	1117	39	1	148	1	TSPAN31	12	58139606	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1539314	58139606	75712289	518	1939										
MDM1	56890	broad.mit.edu	37	chr12	68724964	68724964	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagactcggacaaataagacTttttccacaggaagttcctc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:68724964delT	ENST00000303145.7	-	2	142	c.56delA	c.(55-57)agfs	p.K19fs	MDM1_ENST00000393543.3_Frame_Shift_Del_p.K19fs|MDM1_ENST00000411698.2_Frame_Shift_Del_p.K19fs|MDM1_ENST00000430606.2_Frame_Shift_Del_p.K19fs|MDM1_ENST00000540418.1_5'UTR|MDM1_ENST00000545724.1_5'UTR	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	19						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CAAATAAGACTTTTTCCACAG	0.423													56	82	---	---	---	---						-	68724964	T	-	68724964	7	5	21	1	0	1	0	1	0	0	0	0	9461	1609	56	0	2311	0	MDM1	12	68724964	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	10585358	68724964	65126931	519	1940										
TRHDE	29953	broad.mit.edu	37	chr12	72666576	72666576	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcgatgggggaagacgacgcCgcgcttcgggctggcagcag	19	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:72666576C>T	ENST00000261180.4	+	1	114	c.18C>T	c.(16-18)gcC>gcT	p.A6A	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	6					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AAGACGACGCCGCGCTTCGGG	0.662													11	10					0	0	1	0	0	T	72666576	C	T	72666576	2	4	21	1	0	0	0	0	0	0	0	1	16539	639	23	1		1	TRHDE	12	72666576	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3941612	72666576	61185319	520	1941										
MYF6	4618	broad.mit.edu	37	chr12	81102659	81102659	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtcagcctcgagtagccttCgatgcctttcttccatcgtg	9	14	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:81102659C>T	ENST00000228641.3	+	3	871	c.649C>T	c.(649-651)Cga>Tga	p.R217*		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	217					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						GAGTAGCCTTCGATGCCTTTC	0.527													58	51					0	0	1	0	0	T	81102659	C	T	81102659	4	4	21	1	0	0	0	0	0	1	0	0	10075	876	31	1	659	1	MYF6	12	81102659	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	8436083	81102659	52749236	521	1942										
ANKS1B	56899	broad.mit.edu	37	chr12	99145154	99145154	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acggacttgcgaatgctaacGcggggcttggggatgggttt	17	7	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:99145154G>A	ENST00000547776.2	-	25	3650	c.3651C>T	c.(3649-3651)cgC>cgT	p.R1217R	ANKS1B_ENST00000550693.2_Silent_p.R407R|ANKS1B_ENST00000549493.2_Silent_p.R467R|ANKS1B_ENST00000547446.1_Silent_p.R352R|ANKS1B_ENST00000549025.2_Silent_p.R315R|ANKS1B_ENST00000341752.7_Silent_p.R223R|ANKS1B_ENST00000549558.2_Silent_p.R383R|ANKS1B_ENST00000329257.7_Silent_p.R1217R|ANKS1B_ENST00000547010.1_Silent_p.R733R|ANKS1B_ENST00000333732.7_Silent_p.R247R|ANKS1B_ENST00000546568.1_Silent_p.R383R|ANKS1B_ENST00000546960.1_Silent_p.R443R|ANKS1B_ENST00000332712.7_Silent_p.R407R	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	1217						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GAATGCTAACGCGGGGCTTGG	0.498													18	32					0	0	1	0	0	A	99145154	G	A	99145154	2	1	21	1	0	0	0	0	0	0	0	1	683	1074	38	1		1	ANKS1B	12	99145154	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	18042495	99145154	34706741	522	1943										
SCYL2	55681	broad.mit.edu	37	chr12	100709497	100709497	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttggccctgtgtttaagcaGcaggagccaatccaggtatg	12	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:100709497G>A	ENST00000360820.2	+	9	1694	c.1257G>A	c.(1255-1257)caG>caA	p.Q419Q		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	419					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						TGTTTAAGCAGCAGGAGCCAA	0.338													17	20					0	0	1	0	0	A	100709497	G	A	100709497	2	1	21	1	0	0	0	0	0	0	0	1	14001	962	34	3		3	SCYL2	12	100709497	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1564343	100709497	33142398	523	1944										
ANO4	121601	broad.mit.edu	37	chr12	101437381	101437381	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgataaatactgtccattcAtgaggctgtcagacagctgt	10	8	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:101437381A>G	ENST00000392979.3	+	12	1475	c.1114A>G	c.(1114-1116)Atg>Gtg	p.M372V	ANO4_ENST00000392977.3_Missense_Mutation_p.M407V|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	407						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CTGTCCATTCATGAGGCTGTC	0.393										HNSCC(74;0.22)			22	43					0	0	1	0	0	G	101437381	A	G	101437381	3	3	21	1	0	0	0	0	1	0	0	0	693	217	8	4	1156	4	ANO4	12	101437381	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	727884	101437381	32414514	524	1945										
UTP20	27340	broad.mit.edu	37	chr12	101768587	101768587	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtggtttatttttggtagcGcttaaatagacaacttgctg	10	5	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:101768587G>A	ENST00000261637.4	+	55	7307	c.7131_splice	c.e55-1	p.R2378_splice		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2378					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TTTTGGTAGCGCTTAAATAGA	0.398													44	99					0	0	1	0	0	A	101768587	G	A	101768587	5	1	21	1	0	0	0	0	0	0	1	0	17158	1101	38	1	7351	1	UTP20	12	101768587	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	331206	101768587	32083308	525	1946										
NUP37	79023	broad.mit.edu	37	chr12	102468812	102468812	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaatgatgaatttgaaactgGcttgccattttgccaggata	9	6	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:102468812G>A	ENST00000552283.1	-	9	973	c.834C>T	c.(832-834)agC>agT	p.S278S	NUP37_ENST00000251074.1_Silent_p.S278S			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	278					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						TTTGAAACTGGCTTGCCATTT	0.343													22	24					0	0	1	0	0	A	102468812	G	A	102468812	2	1	21	1	0	0	0	0	0	0	0	1	10811	1194	42	3		3	NUP37	12	102468812	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	700225	102468812	31383083	526	1947										
SLC41A2	84102	broad.mit.edu	37	chr12	105282851	105282851	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaggcagttgccacactgctAgagcacagaagtatggaatg	12	8	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:105282851A>G	ENST00000258538.3	-	4	967	c.840T>C	c.(838-840)tcT>tcC	p.S280S		NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	280						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						CCACACTGCTAGAGCACAGAA	0.388													45	56					0	0	1	0	0	G	105282851	A	G	105282851	2	3	21	1	0	0	0	0	0	0	0	1	14684	407	15	4		4	SLC41A2	12	105282851	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2814039	105282851	28569044	527	1948										
RFC5	5985	broad.mit.edu	37	chr12	118463610	118463610	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctctttccagtggagacatgCgtagggctctgaacattttg	11	9	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:118463610C>T	ENST00000392542.2	+	8	1110	c.577C>T	c.(577-579)Cgt>Tgt	p.R193C	RFC5_ENST00000229043.3_Missense_Mutation_p.R129C|RFC5_ENST00000454402.2_Missense_Mutation_p.R214C	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	214					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGAGACATGCGTAGGGCTCT	0.423													38	55					0	0	1	0	0	T	118463610	C	T	118463610	3	4	21	1	0	0	0	0	1	0	0	0	13299	768	27	1	672	1	RFC5	12	118463610	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	13180759	118463610	15388285	528	1949										
SUDS3	64426	broad.mit.edu	37	chr12	118814517	118814522	+	In_Frame_Del	DEL	GGCCCC	GGCCCC	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgagtgccgcggggctgctGgccccggccccggcccaggc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:118814517_118814522delGGCCCC	ENST00000543473.1	+	1	333_338	c.21_26delGGCCCC	c.(19-27)ctg>ct	p.LAP7del	SUDS3_ENST00000397564.2_In_Frame_Del_p.LAP7del	NM_022491.2	NP_071936.2	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3 homolog (S. cerevisiae)	7					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding			breast(1)|lung(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGGGCTGCTGGCCCCGGCCCCGGCC	0.743													5	9	---	---	---	---						-	118814522	GGCCCC	-	118814517	7	5	21	1	0	1	0	1	0	0	0	0	15422	1335	47	0	23	0	SUDS3	12	118814517	In_Frame_Del	DEL	GGCCCC	TCGA-N7-A4Y0-01A-12D-A28R-08	350907	118814517	15037378	529	1950										
SRRM4	84530	broad.mit.edu	37	chr12	119592107	119592107	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcgggagcgcgagcgagcgcGtcggagacgtcggtcctact	18	12	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:119592107G>A	ENST00000267260.4	+	12	1839	c.1451G>A	c.(1450-1452)cGt>cAt	p.R484H		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	484	Arg-rich.|Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GAGCGAGCGCGTCGGAGACGT	0.682													8	20					0	0	1	0	0	A	119592107	G	A	119592107	3	1	21	1	0	0	0	0	1	0	0	0	15226	1145	40	1	1497	1	SRRM4	12	119592107	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	777590	119592107	14259788	530	1951										
CIT	11113	broad.mit.edu	37	chr12	120190012	120190012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgtagctctgtgagctggCgcttgagctccagtttctgc	13	11	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:120190012C>T	ENST00000392521.2	-	23	2802	c.2747G>A	c.(2746-2748)cGc>cAc	p.R916H	CIT_ENST00000261833.7_Missense_Mutation_p.R874H|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	874					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGTGAGCTGGCGCTTGAGCTC	0.582													19	17					0	0	1	0	0	T	120190012	C	T	120190012	3	4	21	1	0	0	0	0	1	0	0	0	3461	768	27	1	3566	1	CIT	12	120190012	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	597905	120190012	13661883	531	1952										
COX6A1	1337	broad.mit.edu	37	chr12	120878307	120878307	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctattccataaccctcatgtGaatccacttccaactggcta	4	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:120878307G>A	ENST00000229379.2	+	3	334	c.297G>A	c.(295-297)gtG>gtA	p.V99V	AL021546.6_ENST00000551806.1_Intron	NM_004373.3	NP_004364.2	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	99					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity					all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCCTCATGTGAATCCACTTC	0.458													19	23					0	0	1	0	0	A	120878307	G	A	120878307	2	1	21	1	0	0	0	0	0	0	0	1	3797	1277	45	3		3	COX6A1	12	120878307	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	688295	120878307	12973588	532	1953										
ATP6V0A2	23545	broad.mit.edu	37	chr12	124228411	124228411	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccactcggatccgcaccaAcaaattcaccgagggatttc	7	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:124228411A>G	ENST00000330342.3	+	10	1366	c.1118A>G	c.(1117-1119)aAc>aGc	p.N373S		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	373					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ATCCGCACCAACAAATTCACC	0.453													14	160					0	0	1	0	0	G	124228411	A	G	124228411	3	3	21	1	0	0	0	0	1	0	0	0	1167	43	2	4	1156	4	ATP6V0A2	12	124228411	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3350104	124228411	9623484	533	1954										
DNAH10	196385	broad.mit.edu	37	chr12	124418011	124418011	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctccaccttgttcacacaagTgaccaagttccaggatgcag	8	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:124418011T>C	ENST00000409039.3	+	76	13101	c.13076T>C	c.(13075-13077)gTg>gCg	p.V4359A	DNAH10OS_ENST00000514254.2_Intron|CCDC92_ENST00000544798.1_Intron	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4359					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCACACAAGTGACCAAGTTC	0.592													53	52					0	0	1	0	0	C	124418011	T	C	124418011	3	2	21	1	0	0	0	0	1	0	0	0	4626	1696	59	4	13378	4	DNAH10	12	124418011	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	189600	124418011	9433884	534	1955										
UBC	7316	broad.mit.edu	37	chr12	125397363	125397363	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtcactcggctccacttcgaGagtgatggtcttaccagtca	10	12	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:125397363G>A	ENST00000536769.1	-	1	2531	c.955C>T	c.(955-957)Ctc>Ttc	p.L319F	UBC_ENST00000339647.5_Missense_Mutation_p.L319F|UBC_ENST00000546120.1_Missense_Mutation_p.L243F|UBC_ENST00000538617.1_Intron			P0CG48	UBC_HUMAN	ubiquitin C	319	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TCCACTTCGAGAGTGATGGTC	0.517													70	189					0	0	1	0	0	A	125397363	G	A	125397363	3	1	21	1	0	0	0	0	1	0	0	0	16902	942	33	3	1106	3	UBC	12	125397363	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	979352	125397363	8454532	535	1956										
RIMBP2	23504	broad.mit.edu	37	chr12	130926863	130926863	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggacgttgtagctgctcaccGttccccatcctggtggcacc	11	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:130926863G>A	ENST00000261655.4	-	8	1146	c.983C>T	c.(982-984)aCg>aTg	p.T328M	RIMBP2_ENST00000536002.1_Missense_Mutation_p.T236M|RIMBP2_ENST00000535703.1_Missense_Mutation_p.T236M	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	328	Fibronectin type-III 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCTGCTCACCGTTCCCCATCC	0.562													54	67					0	0	1	0	0	A	130926863	G	A	130926863	3	1	21	1	0	0	0	0	1	0	0	0	13412	1145	40	1	2223	1	RIMBP2	12	130926863	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5529500	130926863	2925032	536	1957										
P2RX2	0	broad.mit.edu	37	chr12	133196264	133196264	+	Splice_Site	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccccctctttctgagcccaGgggggcagcgtgttcagcat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:133196264delG	ENST00000389110.3	+	3	346		c.e3-1		P2RX2_ENST00000348800.5_Splice_Site|P2RX2_ENST00000350048.5_Intron|P2RX2_ENST00000343948.4_Splice_Site|P2RX2_ENST00000352418.4_Intron|P2RX2_ENST00000351222.4_Intron|P2RX2_ENST00000449132.2_Intron	NM_170682.2|NM_170683.2|NM_174873.1	NP_733782.1|NP_733783.1|NP_777362.1	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 2						positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity			NS(1)|breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(8)|ovary(1)|prostate(3)	20	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		TCTGAGCCCAGGGGGGCAGCG	0.756													25	33	---	---	---	---						-	133196264	G	-	133196264	8	5	21	1	0	1	0	1	0	0	1	0	11386	1014	35	0	319	0	P2RX2	12	133196264	Splice_Site	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2269401	133196264	655631	537	1958										
SACS	26278	broad.mit.edu	37	chr13	23914022	23914022	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttctgaataaccatggaaatAtgatctgatgtcaactcctc	6	9	3	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:23914022A>G	ENST00000382298.3	-	10	4581	c.3993T>C	c.(3991-3993)caT>caC	p.H1331H	SACS_ENST00000382292.3_Silent_p.H1331H|SACS_ENST00000402364.1_Silent_p.H581H	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1331					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CCATGGAAATATGATCTGATG	0.338													18	19					0	0	1	0	0	G	23914022	A	G	23914022	2	3	21	1	0	0	0	0	0	0	0	1	13855	446	16	4		4	SACS	13	23914022	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08		23914022	91255856	538	1959										
SACS	26278	broad.mit.edu	37	chr13	23915781	23915781	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcattacttccttgataagaCgtgcaaatcgttctggattt	7	8	2	2	rs143677534	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:23915781C>T	ENST00000382298.3	-	10	2822	c.2234G>A	c.(2233-2235)cGt>cAt	p.R745H	SACS_ENST00000382292.3_Missense_Mutation_p.R745H|SACS_ENST00000402364.1_5'UTR	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	745				RPCTQLQLLNPERFARLIKEV -> FLFDEDSNGKLKMVAV LITSC (in Ref. 4; BAC03486).	cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTTGATAAGACGTGCAAATCG	0.368													20	30					0	0	1	0	0	T	23915781	C	T	23915781	3	4	21	1	0	0	0	0	1	0	0	0	13855	536	19	1	11509	1	SACS	13	23915781	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1759	23915781	91254097	539	1960										
SPATA13	221178	broad.mit.edu	37	chr13	24860369	24860369	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagctgatcagtgatggcaaCgtggtctgcgcagaagccct	13	11	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:24860369C>T	ENST00000424834.2	+	8	2792	c.2319C>T	c.(2317-2319)aaC>aaT	p.N773N	SPATA13_ENST00000382095.4_Silent_p.N148N|SPATA13_ENST00000409126.1_Silent_p.N70N|SPATA13_ENST00000399949.2_Silent_p.N70N|SPATA13_ENST00000382108.3_Silent_p.N773N|SPATA13_ENST00000343003.6_Silent_p.N92N			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	148					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GTGATGGCAACGTGGTCTGCG	0.587													57	81					0	0	1	0	0	T	24860369	C	T	24860369	2	4	21	1	0	0	0	0	0	0	0	1	15055	535	19	1		1	SPATA13	13	24860369	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	944588	24860369	90309509	540	1961										
ATP8A2	51761	broad.mit.edu	37	chr13	26116151	26116151	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcccaaccgccacctctatgActtcactggaaacttgaact	6	15	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:26116151A>G	ENST00000381655.2	+	9	888	c.746A>G	c.(745-747)gAc>gGc	p.D249G	ATP8A2_ENST00000255283.8_Missense_Mutation_p.D209G	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	209					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CACCTCTATGACTTCACTGGA	0.393													28	33					0	0	1	0	0	G	26116151	A	G	26116151	3	3	21	1	0	0	0	0	1	0	0	0	1191	275	10	4	780	4	ATP8A2	13	26116151	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1255782	26116151	89053727	541	1962										
RXFP2	122042	broad.mit.edu	37	chr13	32351561	32351561	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atttcacagcgcttgtttacGggattaaattccttgttttt	7	7	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:32351561G>A	ENST00000298386.2	+	8	761	c.690G>A	c.(688-690)acG>acA	p.T230T	RXFP2_ENST00000380314.1_Silent_p.T230T	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	230						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GCTTGTTTACGGGATTAAATT	0.318													6	13					0	0	1	0	0	A	32351561	G	A	32351561	2	1	21	1	0	0	0	0	0	0	0	1	13811	1103	39	1		1	RXFP2	13	32351561	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6235410	32351561	82818317	542	1963										
NBEA	26960	broad.mit.edu	37	chr13	35624439	35624439	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaaggagttggttactctgcTcattttgttggcaactgttt	10	6	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:35624439T>A	ENST00000400445.3	+	6	1413	c.879T>A	c.(877-879)gcT>gcA	p.A293A	NBEA_ENST00000379939.2_Silent_p.A293A|NBEA_ENST00000310336.4_Silent_p.A293A|NBEA_ENST00000540320.1_Silent_p.A293A	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	293						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GTTACTCTGCTCATTTTGTTG	0.353													8	8					0	0	1	0	0	A	35624439	T	A	35624439	2	1	21	1	0	0	0	0	0	0	0	1	10234	1538	54	4		4	NBEA	13	35624439	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	3272878	35624439	79545439	543	1964										
POSTN	10631	broad.mit.edu	37	chr13	38144790	38144790	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccatcaatgattttggtgtaTtttttaataattggctctaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:38144790delT	ENST00000379747.4	-	19	2313	c.2196delA	c.(2194-2196)aafs	p.K732fs	POSTN_ENST00000379749.4_Frame_Shift_Del_p.K732fs|POSTN_ENST00000379743.4_Frame_Shift_Del_p.K705fs|POSTN_ENST00000379742.4_Frame_Shift_Del_p.K675fs|POSTN_ENST00000497145.1_5'UTR|POSTN_ENST00000541481.1_Intron|POSTN_ENST00000541179.1_Frame_Shift_Del_p.K705fs	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	732					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTTTGGTGTATTTTTTAATAA	0.343													32	63	---	---	---	---						-	38144790	T	-	38144790	7	5	21	1	0	1	0	1	0	0	0	0	12306	1490	52	0	334	0	POSTN	13	38144790	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2520351	38144790	77025088	544	1965										
ZC3H13	23091	broad.mit.edu	37	chr13	46543691	46543691	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgcttttctttttctgtccTttttttggtgaaaatacttg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:46543691delT	ENST00000242848.4	-	14	3336	c.2988delA	c.(2986-2988)aafs	p.K996fs	ZC3H13_ENST00000282007.3_Frame_Shift_Del_p.K996fs|ZC3H13_ENST00000378921.2_5'UTR			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	996	Lys-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TTTTCTGTCCTTTTTTTGGTG	0.333													8	73	---	---	---	---						-	46543691	T	-	46543691	7	5	21	1	0	1	0	1	0	0	0	0	17623	1606	56	0	1722	0	ZC3H13	13	46543691	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	8398901	46543691	68626187	545	1966										
DHRS12	79758	broad.mit.edu	37	chr13	52365373	52365373	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcttgggatcagacaagtcCacaatgtgcagaaaaatgtt	10	7	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:52365373C>A	ENST00000218981.1	-	3	258	c.147G>T	c.(145-147)gtG>gtT	p.V49V	DHRS12_ENST00000490949.1_5'UTR|DHRS12_ENST00000280056.2_Silent_p.V49V|DHRS12_ENST00000444610.2_Silent_p.V98V	NM_024705.2	NP_078981.1	A0PJE2	DHR12_HUMAN	dehydrogenase/reductase (SDR family) member 12	98							binding|oxidoreductase activity			cervix(1)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	7		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)		CAGACAAGTCCACAATGTGCA	0.299													8	22					0.0477658	0.0479846	1	1	0	A	52365373	C	A	52365373	2	1	21	1	0	0	0	0	0	0	0	1	4516	581	21	5		5	DHRS12	13	52365373	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5821682	52365373	62804505	546	1967										
CCDC70	83446	broad.mit.edu	37	chr13	52439515	52439515	+	Translation_Start_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caagggtcctgtcatccctcAtggccaccccgccattccgg	9	18	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:52439515A>G	ENST00000242819.4	+	2	297	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	1						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GTCATCCCTCATGGCCACCCC	0.597													31	21					0	0	1	0	0	G	52439515	A	G	52439515	1	3	21	1	0	0	0	0	0	0	0	0	2863	217	8	4		4	CCDC70	13	52439515	Translation_Start_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	74142	52439515	62730363	547	1968										
NEK5	341676	broad.mit.edu	37	chr13	52676360	52676360	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggagctcacgagaaaacccCggagatattggggcaaaatg	13	8	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:52676360C>T	ENST00000355568.4	-	10	817	c.678G>A	c.(676-678)ccG>ccA	p.P226P		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	226	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GAGAAAACCCCGGAGATATTG	0.423													112	151					0	0	1	0	0	T	52676360	C	T	52676360	2	4	21	1	0	0	0	0	0	0	0	1	10373	639	23	1		1	NEK5	13	52676360	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	236845	52676360	62493518	548	1969										
MYCBP2	23077	broad.mit.edu	37	chr13	77844149	77844149	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagcataccctaaccaagacTttttttcttttctgtttcta							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:77844149delT	ENST00000407578.2	-	7	1504	c.1238delA	c.(1237-1239)agfs	p.K413fs	MYCBP2_ENST00000544440.2_Frame_Shift_Del_p.K375fs|MYCBP2_ENST00000357337.6_Frame_Shift_Del_p.K375fs|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	375					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TAACCAAGACTTTTTTTCTTT	0.289													60	99	---	---	---	---						-	77844149	T	-	77844149	7	5	21	1	0	1	0	1	0	0	0	0	10065	1609	56	0	13106	0	MYCBP2	13	77844149	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	25167789	77844149	37325729	549	1970										
COL4A2	1284	broad.mit.edu	37	chr13	111117897	111117897	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccctggagacgccggcttacCtggaccaccaggcttcctgg	12	16	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:111117897C>A	ENST00000360467.5	+	25	2228	c.1922C>A	c.(1921-1923)cCt>cAt	p.P641H		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	641	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GCCGGCTTACCTGGACCACCA	0.597													35	32					1.06647e-15	1.15184e-15	1	1	0	A	111117897	C	A	111117897	3	1	21	1	0	0	0	0	1	0	0	0	3713	681	24	5	2016	5	COL4A2	13	111117897	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	33273748	111117897	4051981	550	1971										
MCF2L	23263	broad.mit.edu	37	chr13	113729502	113729502	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgcaccgccgcctggagaCggtaggccgagccggacccc	15	17	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:113729502C>T	ENST00000397030.1	+	11	1443	c.1407_splice	c.e11+1	p.T469_splice	MCF2L_ENST00000434480.2_Splice_Site_p.T442_splice|MCF2L_ENST00000442652.2_Splice_Site_p.T466_splice|MCF2L_ENST00000375597.4_Splice_Site_p.T434_splice|MCF2L_ENST00000421756.1_Splice_Site_p.T440_splice|MCF2L_ENST00000375608.3_Splice_Site_p.T466_splice|MCF2L_ENST00000375604.2_Splice_Site_p.T493_splice|MCF2L_ENST00000535094.2_Splice_Site_p.T436_splice|MCF2L_ENST00000375601.3_Splice_Site_p.T440_splice|MCF2L_ENST00000423482.2_Splice_Site_p.T434_splice			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	466					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGCCTGGAGACGGTAGGCCGA	0.687													11	14					0	0	1	0	0	T	113729502	C	T	113729502	5	4	21	1	0	0	0	0	0	0	1	0	9428	550	19	1	1615	1	MCF2L	13	113729502	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2611605	113729502	1440376	551	1972										
OR4K13	390433	broad.mit.edu	37	chr14	20502375	20502375	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcaagtttaatcacaaggggAaggtcacagaaaaagctgtc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:20502375delA	ENST00000315693.2	-	1	544	c.543delT	c.(541-543)ctfs	p.L181fs		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TCACAAGGGGAAGGTCACAGA	0.483													29	71	---	---	---	---						-	20502375	A	-	20502375	7	5	21	1	0	1	0	1	0	0	0	0	11115	233	9	0	373	0	OR4K13	14	20502375	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08		20502375	86847165	552	1973										
OR4K13	390433	broad.mit.edu	37	chr14	20502395	20502395	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaggtcacagaaaaagctgtCtataacattgggaccacaga	9	8	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:20502395C>A	ENST00000315693.2	-	1	524	c.523G>T	c.(523-525)Gac>Tac	p.D175Y		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAAAAGCTGTCTATAACATTG	0.473													38	58					1.30998e-17	1.42185e-17	1	1	0	A	20502395	C	A	20502395	3	1	21	1	0	0	0	0	1	0	0	0	11115	913	32	2	393	2	OR4K13	14	20502395	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	20	20502395	86847145	553	1974										
MYH7	4625	broad.mit.edu	37	chr14	23887559	23887559	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctcctcgtactgctcccgCagcaggtcgcagtcatgccg	10	17	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:23887559C>T	ENST00000355349.3	-	30	4191	c.4029G>A	c.(4027-4029)ctG>ctA	p.L1343L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1343					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACTGCTCCCGCAGCAGGTCGC	0.657													40	60					0	0	1	0	0	T	23887559	C	T	23887559	2	4	21	1	0	0	0	0	0	0	0	1	10086	697	25	3		3	MYH7	14	23887559	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3385164	23887559	83461981	554	1975										
AP1G2	8906	broad.mit.edu	37	chr14	24033540	24033540	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtagacagttgggactattAcctaatgttcctgtcactgt	10	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:24033540A>G	ENST00000308724.5	-	9	1733		c.e9+1		AP1G2_ENST00000397120.3_Splice_Site|RP11-66N24.3_ENST00000555968.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit						interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		TGGGACTATTACCTAATGTTC	0.512													30	42					0	0	1	0	0	G	24033540	A	G	24033540	5	3	21	1	0	0	0	0	0	0	1	0	729	405	14	4	1430	4	AP1G2	14	24033540	Splice_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	145981	24033540	83316000	555	1976										
RABGGTA	5875	broad.mit.edu	37	chr14	24734837	24734837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcttaggtgaggacgctgCtaactgaaggcagcagttca	12	10	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:24734837C>T	ENST00000399409.3	-	16	2171	c.1688G>A	c.(1687-1689)aGc>aAc	p.S563N	RABGGTA_ENST00000560777.1_Missense_Mutation_p.S172N|RABGGTA_ENST00000216840.6_Missense_Mutation_p.S563N	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	563					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		GAGGACGCTGCTAACTGAAGG	0.582													26	19					0	0	1	0	0	T	24734837	C	T	24734837	3	4	21	1	0	0	0	0	1	0	0	0	13018	797	28	3	19	3	RABGGTA	14	24734837	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	701297	24734837	82614703	556	1977										
NYNRIN	57523	broad.mit.edu	37	chr14	24884026	24884026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgaccttgactcttcgctggCgtcagtgttcagggtggagt	14	10	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:24884026C>T	ENST00000382554.3	+	9	3389	c.3071C>T	c.(3070-3072)gCg>gTg	p.A1024V		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1024					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TCTTCGCTGGCGTCAGTGTTC	0.627													28	30					0	0	1	0	0	T	24884026	C	T	24884026	3	4	21	1	0	0	0	0	1	0	0	0	10843	768	27	1	3101	1	NYNRIN	14	24884026	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	149189	24884026	82465514	557	1978										
FOXG1	2290	broad.mit.edu	37	chr14	29237048	29237048	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccgccgttcagctacaacgCgctcatcatgatggccatcc	9	16	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:29237048C>T	ENST00000382535.3	+	2	932	c.563C>T	c.(562-564)gCg>gTg	p.A188V	FOXG1_ENST00000313071.4_Missense_Mutation_p.A188V			P55316	FOXG1_HUMAN	forkhead box G1	188					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AGCTACAACGCGCTCATCATG	0.612													16	29					0	0	1	0	0	T	29237048	C	T	29237048	3	4	21	1	0	0	0	0	1	0	0	0	6040	768	27	1	565	1	FOXG1	14	29237048	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4353022	29237048	78112492	558	1979										
NKX2-1	7080	broad.mit.edu	37	chr14	36987157	36987157	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggccatgttcttgctcacgtCccccagcgagcccaggccgc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:36987157delC	ENST00000518149.1	-	3	1047	c.442delG	c.(442-444)acfs	p.D148fs	RP11-896J10.3_ENST00000521945.1_RNA|NKX2-1_ENST00000498187.2_Frame_Shift_Del_p.D148fs|NKX2-1_ENST00000354822.5_Frame_Shift_Del_p.D178fs|NKX2-1_ENST00000522719.2_Frame_Shift_Del_p.D148fs			P43699	NKX21_HUMAN	NK2 homeobox 1	148					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		TTGCTCACGTCCCCCAGCGAG	0.687			A		NSCLC								13	26	---	---	---	---						-	36987157	C	-	36987157	7	5	21	1	0	1	0	1	0	0	0	0	10495	855	30	0	677	0	NKX2-1	14	36987157	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7750109	36987157	70362383	559	1980										
HIF1A	3091	broad.mit.edu	37	chr14	62207260	62207260	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atattgtttttatgtggataGtgatatggtcaatgaattca	9	2	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:62207260G>T	ENST00000394997.1	+	11	1842	c.1577G>T	c.(1576-1578)aGt>aTt	p.S526I	HIF1A_ENST00000539097.1_Missense_Mutation_p.S549I|HIF1A_ENST00000337138.4_Missense_Mutation_p.S525I|RP11-618G20.1_ENST00000555937.1_RNA|HIF1A_ENST00000323441.6_Missense_Mutation_p.S525I|HIF1A_ENST00000557538.1_Missense_Mutation_p.S466I|HIF1A-AS2_ENST00000554254.1_lincRNA			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	525	ODD.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TATGTGGATAGTGATATGGTC	0.328													28	31					5.61819e-17	6.0754e-17	1	1	0	T	62207260	G	T	62207260	3	4	21	1	0	0	0	0	1	0	0	0	7143	1029	36	5	1616	5	HIF1A	14	62207260	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	25220103	62207260	45142280	560	1981										
SNAPC1	6617	broad.mit.edu	37	chr14	62242911	62242911	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcagcttgataaaggatgaTttttttgacaatattaagaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:62242911delT	ENST00000216294.4	+	5	737	c.633delT	c.(631-633)gafs	p.D211fs	RP11-618G20.1_ENST00000555937.1_RNA	NM_003082.3	NP_003073.1	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex, polypeptide 1, 43kDa	211	SNAPC4-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding	p.D214fs*1(2)		endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		TAAAGGATGATTTTTTTGACA	0.358													19	32	---	---	---	---						-	62242911	T	-	62242911	7	5	21	1	0	1	0	1	0	0	0	0	14887	1490	52	0	651	0	SNAPC1	14	62242911	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	35651	62242911	45106629	561	1982										
ZFYVE26	23503	broad.mit.edu	37	chr14	68215288	68215288	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggacaagggctgtggcccgTgagtgttcttgcttcacagc	14	10	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:68215288T>C	ENST00000347230.4	-	42	7623	c.7485A>G	c.(7483-7485)tcA>tcG	p.S2495S		NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2495					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTGTGGCCCGTGAGTGTTCTT	0.562													36	54					0	0	1	0	0	C	68215288	T	C	68215288	2	2	21	1	0	0	0	0	0	0	0	1	17725	1683	59	4		4	ZFYVE26	14	68215288	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	5972377	68215288	39134252	562	1983										
SLC39A9	55334	broad.mit.edu	37	chr14	69925096	69925096	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagagcagtaaagaagcccTttcagaggtgaacgccacgg	12	10	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:69925096T>A	ENST00000031146.4	+	6	1190	c.512T>A	c.(511-513)cTt>cAt	p.L171H	SLC39A9_ENST00000556605.1_Intron|SLC39A9_ENST00000336643.5_Missense_Mutation_p.L237H|SLC39A9_ENST00000555245.1_3'UTR|SLC39A9_ENST00000557046.1_Missense_Mutation_p.L214H			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	237					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		AAAGAAGCCCTTTCAGAGGTG	0.468													90	87					0	0	1	0	0	A	69925096	T	A	69925096	3	1	21	1	0	0	0	0	1	0	0	0	14679	1609	56	4	736	4	SLC39A9	14	69925096	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1709808	69925096	37424444	563	1984										
SIPA1L1	26037	broad.mit.edu	37	chr14	72054754	72054755	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagttatggctcctgtaggaINScccccccgaagtgaaggttc					rs12884638	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:72054754_72054755insC	ENST00000555818.1	+	2	513_514	c.165_166insC	c.(163-168)ggccccfs	p.GP55fs	SIPA1L1_ENST00000381232.3_Frame_Shift_Ins_p.GP55fs|SIPA1L1_ENST00000358550.2_Frame_Shift_Ins_p.GP55fs	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	55					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTCCTGTAGGACCCCCCCGAAG	0.535													56	90	---	---	---	---						C	72054755	-	C	72054754	7	5	21	1	0	1	1	0	0	0	0	0	14383	262	10	0	167	0	SIPA1L1	14	72054754	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	2129658	72054754	35294786	564	1985										
RBM25	58517	broad.mit.edu	37	chr14	73577560	73577560	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggaacaagaggctgagaggCgcaggcagccacaaataaag	14	8	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:73577560C>T	ENST00000261973.7	+	15	1999	c.1714C>T	c.(1714-1716)Cgc>Tgc	p.R572C	RBM25_ENST00000532483.1_3'UTR|RBM25_ENST00000527432.1_Missense_Mutation_p.R572C	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	572	Glu-rich.|Necessary for nuclear speckle localization.			RRRQ -> EAQE (in Ref. 8; AAC41999).	apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		GGCTGAGAGGCGCAGGCAGCC	0.388													7	18					0	0	1	0	0	T	73577560	C	T	73577560	3	4	21	1	0	0	0	0	1	0	0	0	13176	768	27	1	1768	1	RBM25	14	73577560	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1522806	73577560	33771980	565	1986										
PSEN1	5663	broad.mit.edu	37	chr14	73637521	73637521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atagaatgacaatagagaacGgcaggagcacaacgacagac	11	8	0	4	rs63750592		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:73637521G>A	ENST00000324501.5	+	4	376	c.104G>A	c.(103-105)cGg>cAg	p.R35Q	PSEN1_ENST00000394164.1_Missense_Mutation_p.R31Q|PSEN1_ENST00000406768.1_5'UTR|PSEN1_ENST00000557511.1_Missense_Mutation_p.R35Q|PSEN1_ENST00000344094.3_Missense_Mutation_p.R35Q|PSEN1_ENST00000261970.3_Missense_Mutation_p.R35Q|PSEN1_ENST00000394157.3_Missense_Mutation_p.R35Q|PSEN1_ENST00000357710.4_Missense_Mutation_p.R31Q|PSEN1_ENST00000553447.2_3'UTR	NM_000021.3|NM_007318.2	NP_000012.1|NP_015557.2	P49768	PSN1_HUMAN	presenilin 1	35					amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		AATAGAGAACGGCAGGAGCAC	0.478													8	25					0	0	1	0	0	A	73637521	G	A	73637521	3	1	21	1	0	0	0	0	1	0	0	0	12698	1116	39	1	110	1	PSEN1	14	73637521	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	59961	73637521	33712019	566	1987										
YLPM1	56252	broad.mit.edu	37	chr14	75248388	75248388	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cattgccaccaccagtgatgCcccctgccctccctgctaca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:75248388delC	ENST00000325680.7	+	4	1766	c.1642delC	c.(1642-1644)ccfs	p.P549fs	YLPM1_ENST00000238571.3_Intron|YLPM1_ENST00000552421.1_Frame_Shift_Del_p.P549fs	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ACCAGTGATGCCCCCTGCCCT	0.577													26	357	---	---	---	---						-	75248388	C	-	75248388	7	5	21	1	0	1	0	1	0	0	0	0	17545	739	26	0	1656	0	YLPM1	14	75248388	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1610867	75248388	32101152	567	1988										
RPS6KL1	83694	broad.mit.edu	37	chr14	75388084	75388084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggccagccggatctgcgtgGccgcatccaccagatagtca	13	14	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:75388084G>A	ENST00000555647.1	-	3	448	c.161C>T	c.(160-162)gCc>gTc	p.A54V	RPS6KL1_ENST00000557413.1_Missense_Mutation_p.A54V|RPS6KL1_ENST00000554900.1_Intron|RPS6KL1_ENST00000354625.2_Missense_Mutation_p.A54V|RPS6KL1_ENST00000358328.4_Missense_Mutation_p.A54V			Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	54						ribosome	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GATCTGCGTGGCCGCATCCAC	0.592													36	65					0	0	1	0	0	A	75388084	G	A	75388084	3	1	21	1	0	0	0	0	1	0	0	0	13710	1203	42	3	1504	3	RPS6KL1	14	75388084	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	139696	75388084	31961456	568	1989										
CPSF2	53981	broad.mit.edu	37	chr14	92604647	92604647	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cacagattcattcaatgctaCatatgtacagcctagaagaa	6	9	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:92604647C>T	ENST00000298875.4	+	7	902	c.617C>T	c.(616-618)aCa>aTa	p.T206I		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	206					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TTCAATGCTACATATGTACAG	0.333													4	63					0	0	1	0	0	T	92604647	C	T	92604647	3	4	21	1	0	0	0	0	1	0	0	0	3848	478	17	3	635	3	CPSF2	14	92604647	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	17216563	92604647	14744893	569	1990										
BEGAIN	57596	broad.mit.edu	37	chr14	101004877	101004877	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cggggagccgggcggtccccGgcttggcccgcaggctccac	17	17	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:101004877G>A	ENST00000556751.1	-	5	4423	c.1019C>T	c.(1018-1020)cCg>cTg	p.P340L	BEGAIN_ENST00000443071.2_Missense_Mutation_p.P404L|BEGAIN_ENST00000355173.2_Missense_Mutation_p.P404L			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	404						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				GGCGGTCCCCGGCTTGGCCCG	0.726													9	8					0	0	1	0	0	A	101004877	G	A	101004877	3	1	21	1	0	0	0	0	1	0	0	0	1395	1116	39	1	574	1	BEGAIN	14	101004877	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	8400230	101004877	6344663	570	1991										
DYNC1H1	1778	broad.mit.edu	37	chr14	102506038	102506038	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acattacctttgccatgctgCtggcaagaatcaaactgaag	8	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:102506038C>T	ENST00000360184.4	+	62	11823	c.11659C>T	c.(11659-11661)Ctg>Ttg	p.L3887L	RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3887					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TGCCATGCTGCTGGCAAGAAT	0.537													62	67					0	0	1	0	0	T	102506038	C	T	102506038	2	4	21	1	0	0	0	0	0	0	0	1	4867	796	28	3		3	DYNC1H1	14	102506038	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1501161	102506038	4843502	571	1992										
CDC42BPB	9578	broad.mit.edu	37	chr14	103447224	103447224	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttttcccaatttagaccttcAaaaaacgcatgctttttgaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:103447224delA	ENST00000361246.2	-	8	1314	c.1026delT	c.(1024-1026)ttfs	p.F342fs		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	342	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.E343fs*1(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TTAGACCTTCAAAAAACGCAT	0.458													45	78	---	---	---	---						-	103447224	A	-	103447224	7	5	21	1	0	1	0	1	0	0	0	0	3095	127	5	0	4229	0	CDC42BPB	14	103447224	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	941186	103447224	3902316	572	1993										
CDC42BPB	9578	broad.mit.edu	37	chr14	103465909	103465909	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agaagccggttacctgtgcaCgtaatgaagctgatggatgg	14	7	0	3	rs147856179	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:103465909C>T	ENST00000361246.2	-	5	877	c.589G>A	c.(589-591)Gtg>Atg	p.V197M		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	197	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TACCTGTGCACGTAATGAAGC	0.463													41	78					0	0	1	0	0	T	103465909	C	T	103465909	3	4	21	1	0	0	0	0	1	0	0	0	3095	536	19	1	4678	1	CDC42BPB	14	103465909	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	18685	103465909	3883631	573	1994										
GPR132	29933	broad.mit.edu	37	chr14	105518408	105518408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagaggcccagggaggcccaCggggcagtggtggtcactgg	20	10	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:105518408C>T	ENST00000329797.3	-	4	977	c.66G>A	c.(64-66)ccG>ccA	p.P22P	GPR132_ENST00000392585.2_Silent_p.P13P|GPR132_ENST00000546679.1_5'UTR|GPR132_ENST00000539291.2_Silent_p.P22P	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	22					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		GGGAGGCCCACGGGGCAGTGG	0.622													65	70					0	0	1	0	0	T	105518408	C	T	105518408	2	4	21	1	0	0	0	0	0	0	0	1	6681	523	19	1		1	GPR132	14	105518408	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2052499	105518408	1831132	574	1995										
NUDT14	256281	broad.mit.edu	37	chr14	105643364	105643364	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgaataagagaacggtcacGctgtgtacggggggaggggc	18	6	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:105643364G>A	ENST00000392568.2	-	3	219	c.125_splice	c.e3-1	p.S42_splice	RP11-44N21.4_ENST00000548203.1_RNA	NM_177533.4	NP_803877.2	O95848	NUD14_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 14	42	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			cervix(2)|endometrium(1)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	14		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GAACGGTCACGCTGTGTACGG	0.632										HNSCC(42;0.11)			16	18					0	0	1	0	0	A	105643364	G	A	105643364	5	1	21	1	0	0	0	0	0	0	1	0	10777	1101	38	1	554	1	NUDT14	14	105643364	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	124956	105643364	1706176	575	1996										
MAGEL2	54551	broad.mit.edu	37	chr15	23889906	23889906	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccggagagacacttgcgaccTcagacacaactacgggcaga	11	13	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:23889906T>C	ENST00000532292.1	-	1	1269	c.1175A>G	c.(1174-1176)gAg>gGg	p.E392G		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		ACTTGCGACCTCAGACACAAC	0.622													24	20					0	0	1	0	0	C	23889906	T	C	23889906	3	2	21	1	0	0	0	0	1	0	0	0	9238	1551	54	4	769	4	MAGEL2	15	23889906	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08		23889906	78641486	576	1997										
HERC2	8924	broad.mit.edu	37	chr15	28387443	28387443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagggccacagcaacacgggAggccatgcagtacctccgga	13	13	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:28387443A>G	ENST00000261609.7	-	76	11749	c.11641T>C	c.(11641-11643)Tcc>Ccc	p.S3881P		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3881					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCAACACGGGAGGCCATGCAG	0.527													19	28					0	0	1	0	0	G	28387443	A	G	28387443	3	3	21	1	0	0	0	0	1	0	0	0	7098	304	11	4	2935	4	HERC2	15	28387443	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	4497537	28387443	74143949	577	1998										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32916446	32916446	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgcgggacttcttaagcagTtttttagggaactgccagag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:32916446delT	ENST00000361627.3	+	4	1092	c.370delT	c.(370-372)ttfs	p.F125fs	ARHGAP11A_ENST00000565905.1_5'UTR|ARHGAP11A_ENST00000543522.1_5'UTR|ARHGAP11A_ENST00000567348.1_Frame_Shift_Del_p.F125fs|ARHGAP11A_ENST00000563864.1_Frame_Shift_Del_p.F125fs	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	125	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TCTTAAGCAGTTTTTTAGGGA	0.398													22	19	---	---	---	---						-	32916446	T	-	32916446	7	5	21	1	0	1	0	1	0	0	0	0	860	1725	60	0	384	0	ARHGAP11A	15	32916446	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4529003	32916446	69614946	578	1999										
SLC12A6	9990	broad.mit.edu	37	chr15	34546772	34546772	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcactgtgaaagatggcagCtcgggggacgatatagacct	13	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:34546772C>A	ENST00000354181.3	-	9	1387	c.895G>T	c.(895-897)Gct>Tct	p.A299S	SLC12A6_ENST00000451844.2_Missense_Mutation_p.A111S|SLC12A6_ENST00000560164.1_Missense_Mutation_p.A111S|SLC12A6_ENST00000558589.1_Missense_Mutation_p.A290S|SLC12A6_ENST00000290209.5_Missense_Mutation_p.A248S|SLC12A6_ENST00000397707.2_Missense_Mutation_p.A284S|SLC12A6_ENST00000458406.2_Missense_Mutation_p.A240S|SLC12A6_ENST00000560611.1_Missense_Mutation_p.A299S|SLC12A6_ENST00000397702.2_Missense_Mutation_p.A240S|SLC12A6_ENST00000558667.1_Missense_Mutation_p.A299S			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	299					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AAGATGGCAGCTCGGGGGACG	0.388													31	52					1.06801e-11	1.13671e-11	1	1	0	A	34546772	C	A	34546772	3	1	21	1	0	0	0	0	1	0	0	0	14441	797	28	5	2629	5	SLC12A6	15	34546772	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1630326	34546772	67984620	579	2000										
ZNF770	54989	broad.mit.edu	37	chr15	35273866	35273866	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agacagggttgcccggtgctAccaggaataaaatcctgtga	12	9	0	2	rs151315389	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:35273866A>G	ENST00000356321.4	-	3	2114	c.1770T>C	c.(1768-1770)ggT>ggC	p.G590G		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	590					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		GCCCGGTGCTACCAGGAATAA	0.438													77	95					0	0	1	0	0	G	35273866	A	G	35273866	2	3	21	1	0	0	0	0	0	0	0	1	18192	378	14	4		4	ZNF770	15	35273866	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	727094	35273866	67257526	580	2001										
RASGRP1	10125	broad.mit.edu	37	chr15	38795505	38795505	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggacgtgtttgctaatggTttttggatcaggtttgggag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:38795505delT	ENST00000310803.5	-	11	1573	c.1396delA	c.(1396-1398)ccfs	p.T466fs	RASGRP1_ENST00000450598.2_Intron|RASGRP1_ENST00000558164.1_Intron|RP11-102L12.2_ENST00000560231.1_RNA|RASGRP1_ENST00000559830.1_Intron|RASGRP1_ENST00000561180.1_Frame_Shift_Del_p.T517fs|RASGRP1_ENST00000539159.1_Frame_Shift_Del_p.T418fs	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	466					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTGCTAATGGTTTTTGGATCA	0.443													12	16	---	---	---	---						-	38795505	T	-	38795505	7	5	21	1	0	1	0	1	0	0	0	0	13125	1725	60	0	1025	0	RASGRP1	15	38795505	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	3521639	38795505	63735887	581	2002										
BUB1B	701	broad.mit.edu	37	chr15	40502378	40502378	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tacaagttattctgggtggcGccaagaaactctgcagaatt	10	8	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:40502378G>A	ENST00000287598.6	+	18	2547	c.2352G>A	c.(2350-2352)gcG>gcA	p.A784A	BUB1B_ENST00000412359.3_Silent_p.A798A	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	784	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TCTGGGTGGCGCCAAGAAACT	0.338			"Mis, N, F, S"			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				36	37					0	0	1	0	0	A	40502378	G	A	40502378	2	1	21	1	0	0	0	0	0	0	0	1	1574	1074	38	1		1	BUB1B	15	40502378	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1706873	40502378	62029014	582	2003										
RPUSD2	27079	broad.mit.edu	37	chr15	40861959	40861959	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcgagggcggcctgcgtaaGgtgcggccctattactttga	14	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:40861959G>T	ENST00000315616.7	+	1	461	c.423G>T	c.(421-423)aaG>aaT	p.K141N	RPUSD2_ENST00000559271.1_Splice_Site_p.K141_splice	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	141					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		GCCTGCGTAAGGTGCGGCCCT	0.607													3	19					0.004672	0.00472589	1	1	0	T	40861959	G	T	40861959	3	4	21	1	0	0	0	0	1	0	0	0	13718	991	35	5	425	5	RPUSD2	15	40861959	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	359581	40861959	61669433	583	2004										
ZFYVE19	84936	broad.mit.edu	37	chr15	41099853	41099853	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctggctgcaggagagcgtcCggattccctgctctaggtcg	15	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:41099853C>G	ENST00000355341.4	+	1	567	c.66C>G	c.(64-66)tcC>tcG	p.S22S	ZFYVE19_ENST00000564258.1_5'UTR|ZFYVE19_ENST00000570108.1_Intron|ZFYVE19_ENST00000299173.10_Silent_p.S22S|ZFYVE19_ENST00000336455.5_Intron	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	22							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGAGAGCGTCCGGATTCCCTG	0.692													11	16					0	0	1	0	0	G	41099853	C	G	41099853	2	3	21	1	0	0	0	0	0	0	0	1	17722	639	23	5		5	ZFYVE19	15	41099853	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	237894	41099853	61431539	584	2005										
SPTBN5	51332	broad.mit.edu	37	chr15	42162110	42162110	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgctccatgcgtcgctgcaGcactgcccacgcctgcgtca	10	18	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:42162110G>A	ENST00000320955.6	-	32	6009	c.5782C>T	c.(5782-5784)Ctg>Ttg	p.L1928L		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1928					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CGTCGCTGCAGCACTGCCCAC	0.701													6	4					0	0	1	0	0	A	42162110	G	A	42162110	2	1	21	1	0	0	0	0	0	0	0	1	15177	962	34	3		3	SPTBN5	15	42162110	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1062257	42162110	60369282	585	2006										
ATP8B4	79895	broad.mit.edu	37	chr15	50152666	50152666	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttttgagccttctgccaccGgcggatctggagagaaacag	12	11	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:50152666G>T	ENST00000284509.6	-	28	3445	c.3304C>A	c.(3304-3306)Cgg>Agg	p.R1102R	ATP8B4_ENST00000559829.1_Silent_p.R1102R	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1102					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCTGCCACCGGCGGATCTGG	0.502													40	62					7.40236e-40	8.35505e-40	1	1	0	T	50152666	G	T	50152666	2	4	21	1	0	0	0	0	0	0	0	1	1195	1115	39	5		5	ATP8B4	15	50152666	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7990556	50152666	52378726	586	2007										
UNC13C	440279	broad.mit.edu	37	chr15	54625988	54625988	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aactttcctgcaagcaatacTgaaagactgcaagacctgaa	7	10	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:54625988T>C	ENST00000545554.1	+	15	4518	c.4518T>C	c.(4516-4518)acT>acC	p.T1506T	UNC13C_ENST00000260323.11_Silent_p.T1506T|UNC13C_ENST00000537900.1_Silent_p.T1504T			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1506					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAAGCAATACTGAAAGACTGC	0.348													7	13					0	0	1	0	0	C	54625988	T	C	54625988	2	2	21	1	0	0	0	0	0	0	0	1	17045	1567	55	4		4	UNC13C	15	54625988	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4473322	54625988	47905404	587	2008										
ZNF280D	54816	broad.mit.edu	37	chr15	56970921	56970921	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actgcaactgaaatggtgtgGgaaactgacggtagcagtgc	14	7	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:56970921G>T	ENST00000559237.1	-	10	1747	c.1064C>A	c.(1063-1065)cCc>cAc	p.P355H	ZNF280D_ENST00000396245.1_Missense_Mutation_p.P72H|ZNF280D_ENST00000559000.1_Missense_Mutation_p.P355H|ZNF280D_ENST00000267807.7_Missense_Mutation_p.P368H	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		AAATGGTGTGGGAAACTGACG	0.408													33	48					6.84511e-11	7.26775e-11	1	1	0	T	56970921	G	T	56970921	3	4	21	1	0	0	0	0	1	0	0	0	17874	1232	43	5	1884	5	ZNF280D	15	56970921	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2344933	56970921	45560471	588	2009										
NARG2	79664	broad.mit.edu	37	chr15	60747588	60747588	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctatatcgtcctttgacagCtgcaactttataggcattga	8	9	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:60747588C>A	ENST00000261520.4	-	7	954	c.720G>T	c.(718-720)caG>caT	p.Q240H	NARG2_ENST00000561114.1_Missense_Mutation_p.Q240H|NARG2_ENST00000439632.1_Missense_Mutation_p.Q103H	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	240						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						CCTTTGACAGCTGCAACTTTA	0.333													53	56					1.10885e-35	1.24515e-35	1	1	0	A	60747588	C	A	60747588	3	1	21	1	0	0	0	0	1	0	0	0	10216	796	28	5	2268	5	NARG2	15	60747588	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3776667	60747588	41783804	589	2010										
VPS13C	54832	broad.mit.edu	37	chr15	62174867	62174868	+	Frame_Shift_Ins	INS	-	-	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	attcaatctgaattcctgatINSaaaaagtctcgtttaatagg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:62174867_62174868insA	ENST00000261517.5	-	69	9624_9625	c.9551_9552insT	c.(9550-9552)ttcfs	p.F3184fs	VPS13C_ENST00000249837.3_Frame_Shift_Ins_p.F3141fs|VPS13C_ENST00000395898.3_Frame_Shift_Ins_p.F3141fs|VPS13C_ENST00000395896.4_Frame_Shift_Ins_p.F3184fs	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	3184					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GAATTCCTGATAAAAAGTCTCG	0.371													35	49	---	---	---	---						A	62174868	-	A	62174867	7	5	21	1	0	1	1	0	0	0	0	0	17250	1403	49	0	1805	0	VPS13C	15	62174867	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	1427279	62174867	40356525	590	2011										
VPS13C	54832	broad.mit.edu	37	chr15	62201259	62201259	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcaggtgcagatccctcatgGtaatcagaaaaagttatgac	10	8	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:62201259G>A	ENST00000261517.5	-	65	8983	c.8910C>T	c.(8908-8910)taC>taT	p.Y2970Y	VPS13C_ENST00000395898.3_Silent_p.Y2927Y|VPS13C_ENST00000249837.3_Silent_p.Y2927Y|VPS13C_ENST00000395896.4_Silent_p.Y2970Y	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2970					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ATCCCTCATGGTAATCAGAAA	0.378													24	30					0	0	1	0	0	A	62201259	G	A	62201259	2	1	21	1	0	0	0	0	0	0	0	1	17250	1256	44	3		3	VPS13C	15	62201259	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	26392	62201259	40330133	591	2012										
USP3	9960	broad.mit.edu	37	chr15	63829242	63829242	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggtatgtgaatggccatgcAaaaaaacattatgaagatgc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:63829242delA	ENST00000268049.7	+	4	429	c.105delA	c.(103-105)gcfs	p.A35fs	USP3_ENST00000540797.1_Intron|USP3_ENST00000539772.1_Intron|USP3_ENST00000536001.1_Frame_Shift_Del_p.A57fs|USP3_ENST00000380324.3_Frame_Shift_Del_p.A57fs|USP3_ENST00000558285.1_Frame_Shift_Del_p.A40fs			Q9Y6I4	UBP3_HUMAN	ubiquitin specific peptidase 3	57					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(3)|large_intestine(7)|lung(4)	14				GBM - Glioblastoma multiforme(80;0.0187)		ATGGCCATGCAAAAAAACATT	0.299													10	18	---	---	---	---						-	63829242	A	-	63829242	7	5	21	1	0	1	0	1	0	0	0	0	17119	117	5	0	181	0	USP3	15	63829242	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1627983	63829242	38702150	592	2013										
PIF1	80119	broad.mit.edu	37	chr15	65110488	65110488	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcgaacccaactaccaccCctcgggcaccattcaccagg	6	20	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:65110488C>A	ENST00000268043.4	-	10	1590	c.1496G>T	c.(1495-1497)gGg>gTg	p.G499V	PIF1_ENST00000559239.1_Missense_Mutation_p.G499V|PIF1_ENST00000333425.6_Missense_Mutation_p.G499V			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	499	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						AACTACCACCCCTCGGGCACC	0.612													24	49					1.77063e-15	1.91002e-15	1	1	0	A	65110488	C	A	65110488	3	1	21	1	0	0	0	0	1	0	0	0	11930	623	22	5	445	5	PIF1	15	65110488	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1281246	65110488	37420904	593	2014										
MTFMT	123263	broad.mit.edu	37	chr15	65312544	65312544	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccttcactcaccgtaagtcgCcccctccattggctgctgcc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:65312544delC	ENST00000220058.4	-	5	725	c.712delG	c.(712-714)cgfs	p.A238fs		NM_139242.3	NP_640335.2	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	238						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(3)	10					Tetrahydrofolic acid(DB00116)	CCGTAAGTCGCCCCCTCCATT	0.408													19	35	---	---	---	---						-	65312544	C	-	65312544	7	5	21	1	0	1	0	1	0	0	0	0	9971	739	26	0	477	0	MTFMT	15	65312544	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	202056	65312544	37218848	594	2015										
RAB11A	8766	broad.mit.edu	37	chr15	66170108	66170108	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttctgttttcagatattatcGtggagctgtaggtgccttat	10	6	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:66170108G>A	ENST00000261890.2	+	3	373	c.245G>A	c.(244-246)cGt>cAt	p.R82H	RAB11A_ENST00000435304.2_Missense_Mutation_p.R82H|RAB11A_ENST00000564910.1_Intron|RAB11A_ENST00000565075.1_Missense_Mutation_p.R82H|RAB11A_ENST00000569896.1_Missense_Mutation_p.R82H	NM_001206836.1|NM_004663.4	NP_001193765.1|NP_004654.1	P62491	RB11A_HUMAN	RAB11A, member RAS oncogene family	82					cell cycle|cytokinesis|neuron projection development|plasma membrane to endosome transport|protein localization in plasma membrane|small GTPase mediated signal transduction|vesicle-mediated transport	cleavage furrow|plasma membrane|recycling endosome membrane|trans-Golgi network	GTP binding|GTPase activity|syntaxin binding			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5						AGATATTATCGTGGAGCTGTA	0.358													17	48					0	0	1	0	0	A	66170108	G	A	66170108	3	1	21	1	0	0	0	0	1	0	0	0	12942	1145	40	1	255	1	RAB11A	15	66170108	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	857564	66170108	36361284	595	2016										
CALML4	91860	broad.mit.edu	37	chr15	68486389	68486389	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaagggtgatcttgtggatAaattcatcatacttcacttt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:68486389delA	ENST00000448060.2	-	4	525	c.414delT	c.(412-414)ttfs	p.F138fs	CALML4_ENST00000395465.3_3'UTR|RP11-315D16.2_ENST00000562767.1_3'UTR|CALML4_ENST00000467889.1_Frame_Shift_Del_p.F185fs|CALML4_ENST00000540479.1_Frame_Shift_Del_p.F109fs	NM_001031733.2	NP_001026903.2	Q96GE6	CALL4_HUMAN	calmodulin-like 4	185	EF-hand 3.						calcium ion binding			large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	4						TCTTGTGGATAAATTCATCAT	0.403													40	40	---	---	---	---						-	68486389	A	-	68486389	7	5	21	1	0	1	0	1	0	0	0	0	2606	359	13	0	39	0	CALML4	15	68486389	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2316281	68486389	34045003	596	2017										
UACA	55075	broad.mit.edu	37	chr15	70959372	70959372	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actacctctctagtctctaaTttttttaatgcttgtttagt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:70959372delT	ENST00000322954.6	-	16	3836	c.3651delA	c.(3649-3651)aafs	p.K1217fs	UACA_ENST00000539319.1_Frame_Shift_Del_p.K1108fs|UACA_ENST00000379983.2_Frame_Shift_Del_p.K1204fs|UACA_ENST00000560441.1_Frame_Shift_Del_p.K1202fs	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	1217						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TAGTCTCTAATTTTTTTAATG	0.348													33	68	---	---	---	---						-	70959372	T	-	70959372	7	5	21	1	0	1	0	1	0	0	0	0	16884	1490	52	0	615	0	UACA	15	70959372	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2472983	70959372	31572020	597	2018										
ISLR2	57611	broad.mit.edu	37	chr15	74425609	74425609	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcaccttcgacgcgcttagcGcgctgtcacacttgcaactc	9	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:74425609G>A	ENST00000361742.3	+	4	1283	c.514G>A	c.(514-516)Gcg>Acg	p.A172T	ISLR2_ENST00000435464.1_Missense_Mutation_p.A172T|ISLR2_ENST00000565159.1_Missense_Mutation_p.A172T|ISLR2_ENST00000419208.1_Missense_Mutation_p.A172T|ISLR2_ENST00000565540.1_Missense_Mutation_p.A172T|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000445793.1_Missense_Mutation_p.A172T|ISLR2_ENST00000453268.2_Missense_Mutation_p.A172T	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	172					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						CGCGCTTAGCGCGCTGTCACA	0.667													70	95					0	0	1	0	0	A	74425609	G	A	74425609	3	1	21	1	0	0	0	0	1	0	0	0	7902	1087	38	1	516	1	ISLR2	15	74425609	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3466237	74425609	28105783	598	2019										
CYP1A2	1544	broad.mit.edu	37	chr15	75042527	75042527	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccctcaacaccttctccatcGcctctgacccagcttcctca	3	21	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:75042527G>A	ENST00000343932.4	+	2	511	c.448G>A	c.(448-450)Gcc>Acc	p.A150T		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	150					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding	p.A150T(1)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CTTCTCCATCGCCTCTGACCC	0.622													108	167					0	0	1	0	0	A	75042527	G	A	75042527	3	1	21	1	0	0	0	0	1	0	0	0	4173	1087	38	1	450	1	CYP1A2	15	75042527	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	616918	75042527	27488865	599	2020										
C15orf39	56905	broad.mit.edu	37	chr15	75498963	75498963	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctctggatggcaccttcttgCggggggtgccagctgagggg	18	10	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:75498963C>T	ENST00000360639.2	+	2	894	c.574C>T	c.(574-576)Cgg>Tgg	p.R192W	C15orf39_ENST00000567617.1_Missense_Mutation_p.R192W|C15orf39_ENST00000394987.4_Missense_Mutation_p.R192W			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	192										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						CACCTTCTTGCGGGGGGTGCC	0.627													48	62					0	0	1	0	0	T	75498963	C	T	75498963	3	4	21	1	0	0	0	0	1	0	0	0	1799	759	27	1	576	1	C15orf39	15	75498963	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	456436	75498963	27032429	600	2021										
ADAMTS7	11173	broad.mit.edu	37	chr15	79058095	79058095	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctgggtctcagggactctGtggctgttggcggggctgtc	19	9	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:79058095G>A	ENST00000388820.4	-	19	4368	c.4158C>T	c.(4156-4158)caC>caT	p.H1386H		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1386					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CAGGGACTCTGTGGCTGTTGG	0.682													42	61					0	0	1	0	0	A	79058095	G	A	79058095	2	1	21	1	0	0	0	0	0	0	0	1	270	1368	48	3		3	ADAMTS7	15	79058095	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3559132	79058095	23473297	601	2022										
ALPK3	57538	broad.mit.edu	37	chr15	85383002	85383002	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagggcattgtgtcctgctcAggggtcctggaggtgggcac	17	9	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:85383002A>G	ENST00000258888.5	+	5	1265	c.1098A>G	c.(1096-1098)tcA>tcG	p.S366S		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	366	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGTCCTGCTCAGGGGTCCTGG	0.607													44	64					0	0	1	0	0	G	85383002	A	G	85383002	2	3	21	1	0	0	0	0	0	0	0	1	542	175	7	4		4	ALPK3	15	85383002	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	6324907	85383002	17148390	602	2023										
KLHL25	64410	broad.mit.edu	37	chr15	86312497	86312497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acaggctgttgaagtcctcgCtctgcctcaccgtctcaaag	9	14	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:86312497C>T	ENST00000337975.5	-	2	819	c.545G>A	c.(544-546)aGc>aAc	p.S182N	KLHL25_ENST00000559131.1_Intron|KLHL25_ENST00000536947.1_Missense_Mutation_p.S182N	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	182						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						GAAGTCCTCGCTCTGCCTCAC	0.617													30	36					0	0	1	0	0	T	86312497	C	T	86312497	3	4	21	1	0	0	0	0	1	0	0	0	8422	797	28	3	1228	3	KLHL25	15	86312497	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	929495	86312497	16218895	603	2024										
MCTP2	55784	broad.mit.edu	37	chr15	94899379	94899379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctttagtcctctttgatacGcaacctacggctctctgagt	8	12	2	2	rs142627007	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:94899379G>A	ENST00000357742.4	+	8	1019	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H	MCTP2_ENST00000543482.1_Missense_Mutation_p.R340H|MCTP2_ENST00000557742.1_5'UTR|MCTP2_ENST00000451018.3_Missense_Mutation_p.R340H|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	340					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCTTTGATACGCAACCTACGG	0.388													37	75					0	0	1	0	0	A	94899379	G	A	94899379	3	1	21	1	0	0	0	0	1	0	0	0	9450	1087	38	1	1049	1	MCTP2	15	94899379	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	8586882	94899379	7632013	604	2025										
NOXO1	0	broad.mit.edu	37	chr16	2030447	2030447	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtcgggctccgtgccacgcGctctgcagtcgccagcagcc	13	18	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2030447G>A	ENST00000354249.4	-	4	688	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C	NOXO1_ENST00000566005.1_Missense_Mutation_p.R112C|NOXO1_ENST00000397280.4_Missense_Mutation_p.R113C|TBL3_ENST00000568546.1_3'UTR|NOXO1_ENST00000356120.4_Missense_Mutation_p.R108C	NM_001267721.1|NM_144603.3|NM_172167.2|NM_172168.2	NP_001254650.1|NP_653204.1|NP_751907.1|NP_751908.1	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1	113	PX.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity			lung(2)	2						CGTGCCACGCGCTCTGCAGTC	0.687													34	52					0	0	1	0	0	A	2030447	G	A	2030447	3	1	21	1	0	0	0	0	1	0	0	0	10607	1087	38	1	813	1	NOXO1	16	2030447	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08		2030447	88324306	605	2026										
PKD1	5310	broad.mit.edu	37	chr16	2160364	2160364	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	attgaaggtgcccacggagcGgaaggtgtaagagatggtag	17	5	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2160364G>A	ENST00000262304.4	-	15	5012	c.4804C>T	c.(4804-4806)Cgc>Tgc	p.R1602C	PKD1_ENST00000423118.1_Missense_Mutation_p.R1602C	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1602	PKD 11.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCCACGGAGCGGAAGGTGTAA	0.612													43	54					0	0	1	0	0	A	2160364	G	A	2160364	3	1	21	1	0	0	0	0	1	0	0	0	12010	1116	39	1	8235	1	PKD1	16	2160364	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	129917	2160364	88194389	606	2027										
E4F1	1877	broad.mit.edu	37	chr16	2282537	2282537	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctctgtggggcctccttccgCaccaagggctcactcatccg	10	17	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2282537C>T	ENST00000301727.4	+	5	738	c.690C>T	c.(688-690)cgC>cgT	p.R230R	E4F1_ENST00000564139.1_Silent_p.R230R|E4F1_ENST00000565090.1_Silent_p.R230R	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	230	Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CCTCCTTCCGCACCAAGGGCT	0.692													12	29					0	0	1	0	0	T	2282537	C	T	2282537	2	4	21	1	0	0	0	0	0	0	0	1	4900	697	25	3		3	E4F1	16	2282537	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	122173	2282537	88072216	607	2028										
C16orf59	80178	broad.mit.edu	37	chr16	2511156	2511156	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccaggcctggggcgggccTcagggaccagcaaatggccc	15	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2511156T>G	ENST00000569496.1	+	4	595	c.536T>G	c.(535-537)cTc>cGc	p.L179R	C16orf59_ENST00000361837.4_Missense_Mutation_p.L179R|C16orf59_ENST00000563531.1_Missense_Mutation_p.L179R|C16orf59_ENST00000483320.1_Missense_Mutation_p.L12R			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	179										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				GGGGCGGGCCTCAGGGACCAG	0.677													14	24					0	0	1	0	0	G	2511156	T	G	2511156	3	3	21	1	0	0	0	0	1	0	0	0	1830	1551	54	4	550	4	C16orf59	16	2511156	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	228619	2511156	87843597	608	2029										
NTN3	4917	broad.mit.edu	37	chr16	2522735	2522735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cggccatgcccgccgctgccGcttcaacatggagctgtacc	11	17	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2522735G>A	ENST00000293973.1	+	2	1165	c.962G>A	c.(961-963)cGc>cAc	p.R321H		NM_006181.2	NP_006172.1	O00634	NET3_HUMAN	netrin 3	321	Laminin EGF-like 2.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				breast(1)|central_nervous_system(2)|lung(3)|prostate(1)	7						CGCCGCTGCCGCTTCAACATG	0.692													61	85					0	0	1	0	0	A	2522735	G	A	2522735	3	1	21	1	0	0	0	0	1	0	0	0	10748	1087	38	1	968	1	NTN3	16	2522735	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	11579	2522735	87832018	609	2030										
KREMEN2	79412	broad.mit.edu	37	chr16	3016379	3016379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggcacccccagccctcagcGgccccagcggcacctccacg	11	22	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:3016379G>A	ENST00000572045.1	+	4	720	c.415G>A	c.(415-417)Ggc>Agc	p.G139S	KREMEN2_ENST00000575769.1_Missense_Mutation_p.G139S|KREMEN2_ENST00000575885.1_Missense_Mutation_p.G139S|KREMEN2_ENST00000319500.6_Missense_Mutation_p.G139S|KREMEN2_ENST00000571007.1_Missense_Mutation_p.G139S|KREMEN2_ENST00000303746.5_Missense_Mutation_p.G139S	NM_172229.2	NP_757384.1	Q8NCW0	KREM2_HUMAN	kringle containing transmembrane protein 2	139	WSC.				Wnt receptor signaling pathway	integral to membrane				central_nervous_system(2)|endometrium(1)|large_intestine(1)	4						AGCCCTCAGCGGCCCCAGCGG	0.642													60	96					0	0	1	0	0	A	3016379	G	A	3016379	3	1	21	1	0	0	0	0	1	0	0	0	8485	1116	39	1	429	1	KREMEN2	16	3016379	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	493644	3016379	87338374	610	2031										
ROGDI	79641	broad.mit.edu	37	chr16	4848176	4848176	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtcggacggcagggcaggggCgaacatccgctgcgggaggc	20	11	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:4848176C>T	ENST00000322048.7	-	8	919	c.541G>A	c.(541-543)Gcc>Acc	p.A181T	ROGDI_ENST00000586336.1_5'UTR	NM_024589.2	NP_078865.1	Q9GZN7	ROGDI_HUMAN	rogdi homolog (Drosophila)	181						intracellular				endometrium(2)|lung(1)|ovary(1)|skin(1)	5						AGGGCAGGGGCGAACATCCGC	0.652													7	25					0	0	1	0	0	T	4848176	C	T	4848176	3	4	21	1	0	0	0	0	1	0	0	0	13571	768	27	1	338	1	ROGDI	16	4848176	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1831797	4848176	85506577	611	2032										
MKL2	57496	broad.mit.edu	37	chr16	14355246	14355246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctcagcaccaccgcgccgaGcatgttctctgctgactttc	8	16	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:14355246G>A	ENST00000571589.1	+	17	3417	c.3245G>A	c.(3244-3246)aGc>aAc	p.S1082N	MKL2_ENST00000318282.5_Missense_Mutation_p.S1032N|MKL2_ENST00000341243.5_Missense_Mutation_p.S1071N|MKL2_ENST00000574045.1_Missense_Mutation_p.S1032N	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	1071					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACCGCGCCGAGCATGTTCTCT	0.507													35	45					0	0	1	0	0	A	14355246	G	A	14355246	3	1	21	1	0	0	0	0	1	0	0	0	9649	971	34	3	3153	3	MKL2	16	14355246	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9507070	14355246	75999507	612	2033										
XYLT1	64131	broad.mit.edu	37	chr16	17228506	17228506	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtacctgcagggtagttcccGtacaggtaatagtccagctg	12	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:17228506G>A	ENST00000261381.6	-	9	1935	c.1851C>T	c.(1849-1851)taC>taT	p.Y617Y	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	617					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGTAGTTCCCGTACAGGTAAT	0.572													84	108					0	0	1	0	0	A	17228506	G	A	17228506	2	1	21	1	0	0	0	0	0	0	0	1	17522	1140	40	1		1	XYLT1	16	17228506	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2873260	17228506	73126247	613	2034										
C16orf62	57020	broad.mit.edu	37	chr16	19710892	19710894	+	In_Frame_Del	DEL	CAA	CAA	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttggcccatggggacctacgCaacaacaagctcaaccagct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:19710892_19710894delCAA	ENST00000438132.3	+	30	3030_3032	c.2982_2984delCAA	c.(2980-2985)cgc>cg	p.RN994del	C16orf62_ENST00000543152.1_In_Frame_Del_p.RN654del|C16orf62_ENST00000542263.1_In_Frame_Del_p.RN901del|C16orf62_ENST00000448695.1_In_Frame_Del_p.RN755del|C16orf62_ENST00000417362.2_In_Frame_Del_p.RN812del|C16orf62_ENST00000251143.5_In_Frame_Del_p.RN905del	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	905						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						GGGACCTACGCAACAACAAGCTC	0.596													36	70	---	---	---	---						-	19710894	CAA	-	19710892	7	5	21	1	0	1	0	1	0	0	0	0	1832	697	25	0	2833	0	C16orf62	16	19710892	In_Frame_Del	DEL	CAA	TCGA-N7-A4Y0-01A-12D-A28R-08	2482386	19710892	70643861	614	2035										
GP2	2813	broad.mit.edu	37	chr16	20335435	20335435	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atcgcacccctgggaccctgCtgagttctctgtgcttcgga	11	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:20335435C>T	ENST00000302555.5	-	3	387	c.238G>A	c.(238-240)Gca>Aca	p.A80T	GP2_ENST00000381360.5_Intron|GP2_ENST00000341642.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.A80T			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	80						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TGGGACCCTGCTGAGTTCTCT	0.572													37	45					0	0	1	0	0	T	20335435	C	T	20335435	3	4	21	1	0	0	0	0	1	0	0	0	6621	797	28	3	1415	3	GP2	16	20335435	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	624543	20335435	70019318	615	2036										
DNAH3	55567	broad.mit.edu	37	chr16	20974801	20974801	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gatcaccatcttctccaatcCttgagagaacttccaagacc	5	14	3	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:20974801C>A	ENST00000261383.3	-	53	10404	c.10405G>T	c.(10405-10407)Gga>Tga	p.G3469*	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3469					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCTCCAATCCTTGAGAGAAC	0.512													18	29					1.67942e-08	1.76178e-08	1	1	0	A	20974801	C	A	20974801	4	1	21	1	0	0	0	0	0	1	0	0	4631	690	24	5	1984	5	DNAH3	16	20974801	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	639366	20974801	69379952	616	2037										
ERN2	10595	broad.mit.edu	37	chr16	23711986	23711986	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcaaagtctgcaggtgccaGgggggtctcctgctgcttct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:23711986delG	ENST00000256797.4	-	13	1711	c.1543delC	c.(1543-1545)tgfs	p.L515fs	ERN2_ENST00000457008.2_Frame_Shift_Del_p.L415fs	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	467					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCAGGTGCCAGGGGGGTCTCC	0.627													38	64	---	---	---	---						-	23711986	G	-	23711986	7	5	21	1	0	1	0	1	0	0	0	0	5266	991	35	0	1421	0	ERN2	16	23711986	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2737185	23711986	66642767	617	2038										
GTF3C1	2975	broad.mit.edu	37	chr16	27475772	27475772	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagcggtgtcttcaagagctGggggtggagatggggcctgg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:27475772delG	ENST00000356183.4	-	34	5756	c.5741delC	c.(5740-5742)cafs	p.P1914fs	GTF3C1_ENST00000561623.1_Frame_Shift_Del_p.P1914fs	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1914						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TTCAAGAGCTGGGGGTGGAGA	0.652													88	169	---	---	---	---						-	27475772	G	-	27475772	7	5	21	1	0	1	0	1	0	0	0	0	6912	1348	47	0	604	0	GTF3C1	16	27475772	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3763786	27475772	62878981	618	2039										
ASPHD1	253982	broad.mit.edu	37	chr16	29912571	29912571	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcacttccctgttcctctgGtactgctaccgcctgggctc	8	17	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:29912571G>A	ENST00000308748.5	+	1	531	c.279G>A	c.(277-279)tgG>tgA	p.W93*	ASPHD1_ENST00000483405.1_Intron	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	93					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						TGTTCCTCTGGTACTGCTACC	0.682													55	83					0	0	1	0	0	A	29912571	G	A	29912571	4	1	21	1	0	0	0	0	0	1	0	0	1053	1270	44	3	281	3	ASPHD1	16	29912571	Nonsense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2436799	29912571	60442182	619	2040										
CD2BP2	10421	broad.mit.edu	37	chr16	30364763	30364763	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgaacatgtccagggagggtGggggtgtgggattgtggggt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:30364763delG	ENST00000305596.3	-	5	909	c.734delC	c.(733-735)cafs	p.P246fs	CD2BP2_ENST00000569466.1_Frame_Shift_Del_p.P246fs	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	246					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						CAGGGAGGGTGGGGGTGTGGG	0.612													35	75	---	---	---	---						-	30364763	G	-	30364763	7	5	21	1	0	1	0	1	0	0	0	0	3017	1348	47	0	303	0	CD2BP2	16	30364763	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	452192	30364763	59989990	620	2041										
ZNF785	146540	broad.mit.edu	37	chr16	30594122	30594122	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcgccggtgactgaggaggAgggaagaataggtgaagcgg	20	5	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:30594122A>G	ENST00000395216.2	-	3	1136	c.977T>C	c.(976-978)cTc>cCc	p.L326P	AC002310.7_ENST00000492040.1_RNA|AC002310.7_ENST00000486926.1_RNA|ZNF785_ENST00000470110.1_Missense_Mutation_p.L311P	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						ACTGAGGAGGAGGGAAGAATA	0.647													42	61					0	0	1	0	0	G	30594122	A	G	30594122	3	3	21	1	0	0	0	0	1	0	0	0	18205	304	11	4	244	4	ZNF785	16	30594122	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	229359	30594122	59760631	621	2042										
ITGAX	3687	broad.mit.edu	37	chr16	31382762	31382762	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtctctgagcagaccctggTacagtccaacatctgccttt	9	13	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:31382762T>C	ENST00000268296.4	+	16	2070	c.1949T>C	c.(1948-1950)gTa>gCa	p.V650A	ITGAX_ENST00000562522.1_Missense_Mutation_p.V650A	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	650					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CAGACCCTGGTACAGTCCAAC	0.582													41	38					0	0	1	0	0	C	31382762	T	C	31382762	3	2	21	1	0	0	0	0	1	0	0	0	7932	1638	57	4	2011	4	ITGAX	16	31382762	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	788640	31382762	58971991	622	2043										
CNGB1	1258	broad.mit.edu	37	chr16	57918264	57918264	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgggggctcggggggcgtcCggggcgcgggtgggtcggtg	26	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:57918264C>T	ENST00000564448.1	-	33	3602	c.3542G>A	c.(3541-3543)cGg>cAg	p.R1181Q	CNGB1_ENST00000251102.8_Missense_Mutation_p.R1187Q			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1187					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GGGGGGCGTCCGGGGCGCGGG	0.741													19	35					0	0	1	0	0	T	57918264	C	T	57918264	3	4	21	1	0	0	0	0	1	0	0	0	3623	652	23	1	199	1	CNGB1	16	57918264	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	26535502	57918264	32436489	623	2044										
KIAA0895L	653319	broad.mit.edu	37	chr16	67212216	67212216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagctgacggaaggacatgcGcgcggcgcggtggatggtgt	20	8	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67212216G>A	ENST00000290881.7	-	6	1965	c.1039C>T	c.(1039-1041)Cgc>Tgc	p.R347C	KIAA0895L_ENST00000563831.2_5'UTR|KIAA0895L_ENST00000561679.1_Missense_Mutation_p.R192C|KIAA0895L_ENST00000561621.1_Missense_Mutation_p.R347C|KIAA0895L_ENST00000563902.1_Missense_Mutation_p.R347C			Q68EN5	K895L_HUMAN	KIAA0895-like	347										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						AAGGACATGCGCGCGGCGCGG	0.682													13	8					0	0	1	0	0	A	67212216	G	A	67212216	3	1	21	1	0	0	0	0	1	0	0	0	8239	1087	38	1	388	1	KIAA0895L	16	67212216	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	9293952	67212216	23142537	624	2045										
CTCF	10664	broad.mit.edu	37	chr16	67650654	67650654	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catcctttctctaggtactcGtcctcacaagtgcccagact	6	15	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67650654G>A	ENST00000264010.4	+	5	1403	c.959G>A	c.(958-960)cGt>cAt	p.R320H	CTCF_ENST00000401394.1_5'UTR	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	320					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CTAGGTACTCGTCCTCACAAG	0.488													104	124					0	0	1	0	0	A	67650654	G	A	67650654	3	1	21	1	0	0	0	0	1	0	0	0	4024	1145	40	1	969	1	CTCF	16	67650654	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	438438	67650654	22704099	625	2046										
GFOD2	81577	broad.mit.edu	37	chr16	67709560	67709560	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaagaaacagaagtcatcgCtagtgacgtgccggatgcca	13	9	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67709560C>T	ENST00000268797.7	-	3	1001	c.656G>A	c.(655-657)aGc>aAc	p.S219N	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	219						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GAAGTCATCGCTAGTGACGTG	0.577													31	29					0	0	1	0	0	T	67709560	C	T	67709560	3	4	21	1	0	0	0	0	1	0	0	0	6385	797	28	3	505	3	GFOD2	16	67709560	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	58906	67709560	22645193	626	2047										
CENPT	80152	broad.mit.edu	37	chr16	67863714	67863714	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctgaagatgctcctggcccGtcagcctcagcagtcccctg	10	17	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67863714G>A	ENST00000562787.1	-	12	1688	c.1140C>T	c.(1138-1140)gaC>gaT	p.D380D	CENPT_ENST00000219172.3_Silent_p.D380D|CENPT_ENST00000564817.1_Intron|CENPT_ENST00000440851.2_Silent_p.D380D	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	380					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CTCCTGGCCCGTCAGCCTCAG	0.612													72	82					0	0	1	0	0	A	67863714	G	A	67863714	2	1	21	1	0	0	0	0	0	0	0	1	3264	1136	40	1		1	CENPT	16	67863714	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	154154	67863714	22491039	627	2048										
SLC12A4	6560	broad.mit.edu	37	chr16	67985067	67985067	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tacagaagggaagaagatgcCgaccagcacggtgaaggatg	15	7	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67985067C>T	ENST00000422611.2	-	8	1318	c.1279G>A	c.(1279-1281)Ggc>Agc	p.G427S	SLC12A4_ENST00000576616.1_Missense_Mutation_p.G425S|SLC12A4_ENST00000338335.3_Missense_Mutation_p.G425S|SLC12A4_ENST00000541864.2_Missense_Mutation_p.G394S|SLC12A4_ENST00000537830.2_Missense_Mutation_p.G419S|SLC12A4_ENST00000572037.1_Missense_Mutation_p.G377S|SLC12A4_ENST00000316341.3_Missense_Mutation_p.G425S	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	425					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAGAAGATGCCGACCAGCACG	0.622													72	108					0	0	1	0	0	T	67985067	C	T	67985067	3	4	21	1	0	0	0	0	1	0	0	0	14439	652	23	1	2048	1	SLC12A4	16	67985067	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	121353	67985067	22369686	628	2049										
NFAT5	10725	broad.mit.edu	37	chr16	69726657	69726657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgaattgttttcttctcctCctgcagtttctggaaatgaa	8	8	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:69726657C>T	ENST00000349945.1	+	14	4199	c.2647C>T	c.(2647-2649)Cct>Tct	p.P883S	NFAT5_ENST00000393742.2_Missense_Mutation_p.P883S|NFAT5_ENST00000567239.1_Missense_Mutation_p.P976S|NFAT5_ENST00000354436.2_Missense_Mutation_p.P959S|NFAT5_ENST00000566899.1_Missense_Mutation_p.P883S|NFAT5_ENST00000432919.1_Missense_Mutation_p.P977S	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	959	Poly-Gln.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TTCTTCTCCTCCTGCAGTTTC	0.448													38	54					0	0	1	0	0	T	69726657	C	T	69726657	3	4	21	1	0	0	0	0	1	0	0	0	10406	855	30	3	2979	3	NFAT5	16	69726657	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1741590	69726657	20628096	629	2050										
PDPR	55066	broad.mit.edu	37	chr16	70190614	70190614	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cacaatttttctgaggacacGggggaagagcaagtggtgac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:70190614delG	ENST00000288050.4	+	19	3429	c.2472delG	c.(2470-2472)acfs	p.T824fs	PDPR_ENST00000398122.3_Frame_Shift_Del_p.T724fs|PDPR_ENST00000568530.1_Frame_Shift_Del_p.T824fs|RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000542659.1_Frame_Shift_Del_p.T169fs|PDPR_ENST00000567046.1_Frame_Shift_Del_p.T182fs|PDPR_ENST00000562100.1_3'UTR	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	824					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CTGAGGACACGGGGGAAGAGC	0.557													26	122	---	---	---	---						-	70190614	G	-	70190614	7	5	21	1	0	1	0	1	0	0	0	0	11735	1103	39	0	2538	0	PDPR	16	70190614	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	463957	70190614	20164139	630	2051										
AARS	16	broad.mit.edu	37	chr16	70288530	70288530	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaagccgcccctacctctccAaggtcagcgatctccctctg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:70288530delA	ENST00000261772.8	-	17	2537	c.2394delT	c.(2392-2394)ctfs	p.L798fs		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	798					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	CTACCTCTCCAAGGTCAGCGA	0.547													21	43	---	---	---	---						-	70288530	A	-	70288530	7	5	21	1	0	1	0	1	0	0	0	0	19	117	5	0	532	0	AARS	16	70288530	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	97916	70288530	20066223	631	2052										
MTSS1L	92154	broad.mit.edu	37	chr16	70698625	70698625	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcaggccccgcgtcagcacCatggccaggtcactggcggc	13	17	3	0	rs139508787		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:70698625C>A	ENST00000338779.6	-	14	1621	c.1347G>T	c.(1345-1347)atG>atT	p.M449I	FLJ00418_ENST00000597002.1_De_novo_Start_InFrame	NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	449					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						GCGTCAGCACCATGGCCAGGT	0.667													10	19					6.40141e-05	6.54317e-05	1	1	0	A	70698625	C	A	70698625	3	1	21	1	0	0	0	0	1	0	0	0	10010	594	21	5	904	5	MTSS1L	16	70698625	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	410095	70698625	19656128	632	2053										
ZFHX3	463	broad.mit.edu	37	chr16	72822572	72822572	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcacctgtggttgctgctgCtgctgctgctgctggggggg	18	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:72822572C>T	ENST00000268489.5	-	10	10275	c.9603G>A	c.(9601-9603)caG>caA	p.Q3201Q	ZFHX3_ENST00000397992.5_Silent_p.Q2287Q	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3201	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				gttgctgctgctgctgctgct	0.652													89	117					0	0	1	0	0	T	72822572	C	T	72822572	2	4	21	1	0	0	0	0	0	0	0	1	17691	796	28	3		3	ZFHX3	16	72822572	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2123947	72822572	17532181	633	2054										
CTRB1	1504	broad.mit.edu	37	chr16	75258615	75258615	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcccacagggcgactctggcGgccccctggtctgccaaaag	12	16	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:75258615G>A	ENST00000361017.4	+	7	651	c.643G>A	c.(643-645)Ggc>Agc	p.G215S		NM_001906.4	NP_001897.4			chymotrypsinogen B1											central_nervous_system(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.166)		CGACTCTGGCGGCCCCCTGGT	0.662													28	40					0	0	1	0	0	A	75258615	G	A	75258615	3	1	21	1	0	0	0	0	1	0	0	0	4049	1116	39	1	669	1	CTRB1	16	75258615	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2436043	75258615	15096138	634	2055										
CNTNAP4	85445	broad.mit.edu	37	chr16	76528916	76528916	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtggattagagggaaactgCattgattctcagtattactg	11	5	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:76528916C>T	ENST00000307431.8	+	15	2572	c.2187C>T	c.(2185-2187)tgC>tgT	p.C729C	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Silent_p.C733C|CNTNAP4_ENST00000478060.1_Silent_p.C657C|CNTNAP4_ENST00000377504.4_Silent_p.C681C	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	730	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGGGAAACTGCATTGATTCTC	0.378													49	85					0	0	1	0	0	T	76528916	C	T	76528916	2	4	21	1	0	0	0	0	0	0	0	1	3672	718	25	3		3	CNTNAP4	16	76528916	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1270301	76528916	13825837	635	2056										
WWOX	51741	broad.mit.edu	37	chr16	78458772	78458772	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tattttatttttcaggcctcTtcatgtgcttgtgtgcaacg	8	8	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:78458772T>G	ENST00000566780.1	+	7	977	c.611T>G	c.(610-612)cTt>cGt	p.L204R	WWOX_ENST00000406884.2_Intron|WWOX_ENST00000408984.3_Missense_Mutation_p.L204R|WWOX_ENST00000402655.2_Intron|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	204	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTCAGGCCTCTTCATGTGCTT	0.463													31	337					0	0	1	0	0	G	78458772	T	G	78458772	3	3	21	1	0	0	0	0	1	0	0	0	17473	1609	56	4	699	4	WWOX	16	78458772	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1929856	78458772	11895981	636	2057										
ZDHHC7	55625	broad.mit.edu	37	chr16	85015539	85015539	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcacttgtagatgacttccCcgggcttcagctgcaagctc	11	13	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:85015539C>A	ENST00000313732.4	-	4	729	c.377G>T	c.(376-378)gGg>gTg	p.G126V	ZDHHC7_ENST00000569488.1_Intron|ZDHHC7_ENST00000564466.1_Missense_Mutation_p.G163V	NM_017740.2	NP_060210.2	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7	126						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(6)|lung(4)	10						GATGACTTCCCCGGGCTTCAG	0.527													87	100					3.98749e-38	4.4949e-38	1	1	0	A	85015539	C	A	85015539	3	1	21	1	0	0	0	0	1	0	0	0	17677	623	22	5	569	5	ZDHHC7	16	85015539	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	6556767	85015539	5339214	637	2058										
ZCCHC14	23174	broad.mit.edu	37	chr16	87445609	87445609	+	Missense_Mutation	SNP	A	A	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggggtgccgggggctgctgAtggtggtggtggtggtggtg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:87445609A>C	ENST00000268616.4	-	12	2524	c.2307T>G	c.(2305-2307)caT>caG	p.H769Q		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	769	His-rich.				cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GGGGCTGCtgatggtggtggt	0.667													25	30					0	0	1	0	0	C	87445609	A	C	87445609	3	2	21	1	0	0	0	0	1	0	0	0	17641	330	12	4	550	4	ZCCHC14	16	87445609	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2430070	87445609	2909144	638	2059	10	2								
ZCCHC14	23174	broad.mit.edu	37	chr16	87445612	87445612	+	Silent	SNP	G	G	A													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtgccgggggctgctgatgGtggtggtggtggtggtggtt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:87445612G>A	ENST00000268616.4	-	12	2521	c.2304C>T	c.(2302-2304)caC>caT	p.H768H		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	768	His-rich.				cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GCTGCtgatggtggtggtggt	0.667													26	30					0	0	1	0	0	A	87445612	G	A	87445612	2	1	21	1	0	0	0	0	0	0	0	1	17641	1252	44	3		3	ZCCHC14	16	87445612	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3	87445612	2909141	639	2060	10	2								
KLHDC4	54758	broad.mit.edu	37	chr16	87788830	87788830	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagcgcctcggaggtggactGgggatgtcaactttggtcca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:87788830delG	ENST00000270583.5	-	4	397	c.339delC	c.(337-339)ccfs	p.P113fs	KLHDC4_ENST00000347925.5_Frame_Shift_Del_p.P113fs|KLHDC4_ENST00000353170.5_Frame_Shift_Del_p.P56fs	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	113										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GAGGTGGACTGGGGATGTCAA	0.512													33	48	---	---	---	---						-	87788830	G	-	87788830	7	5	21	1	0	1	0	1	0	0	0	0	8400	1335	47	0	1255	0	KLHDC4	16	87788830	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	343218	87788830	2565923	640	2061										
ZC3H18	124245	broad.mit.edu	37	chr16	88643557	88643557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtggccgagagccctgaacGggatcctcactctccagagg	13	13	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:88643557G>A	ENST00000301011.5	+	2	226	c.26G>A	c.(25-27)cGg>cAg	p.R9Q	ZC3H18_ENST00000452588.2_Missense_Mutation_p.R9Q	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	9						nucleus	nucleic acid binding|zinc ion binding	p.R9L(1)		endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGCCCTGAACGGGATCCTCAC	0.547													25	44					0	0	1	0	0	A	88643557	G	A	88643557	3	1	21	1	0	0	0	0	1	0	0	0	17626	1116	39	1	28	1	ZC3H18	16	88643557	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	854727	88643557	1711196	641	2062										
SPG7	6687	broad.mit.edu	37	chr16	89598886	89598886	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcaggcctcggcgctgcccGtgtgcggagcctctttaagg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:89598886delG	ENST00000268704.2	+	9	1181	c.1166delG	c.(1165-1167)ctfs	p.R389fs	SPG7_ENST00000341316.2_Frame_Shift_Del_p.R389fs	NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	389					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGCGCTGCCCGTGTGCGGAGC	0.582													57	103	---	---	---	---						-	89598886	G	-	89598886	7	5	21	1	0	1	0	1	0	0	0	0	15099	1145	40	0	1200	0	SPG7	16	89598886	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	955329	89598886	755867	642	2063										
SPG7	6687	broad.mit.edu	37	chr16	89617001	89617001	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggctggatgctggagcacaCggaggccgtgatgaaggtgg	20	7	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:89617001C>T	ENST00000268704.2	+	13	1778	c.1763C>T	c.(1762-1764)aCg>aTg	p.T588M		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	588					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		CTGGAGCACACGGAGGCCGTG	0.612													46	45					0	0	1	0	0	T	89617001	C	T	89617001	3	4	21	1	0	0	0	0	1	0	0	0	15099	536	19	1	1963	1	SPG7	16	89617001	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	18115	89617001	737752	643	2064										
MC1R	4157	broad.mit.edu	37	chr16	89985820	89985820	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctcagcctggggctggtgAgcttggtggagaacgcgctg	17	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:89985820A>G	ENST00000555427.1	+	3	2457	c.154A>G	c.(154-156)Agc>Ggc	p.S52G	MC1R_ENST00000555147.1_Missense_Mutation_p.S52G|TUBB3_ENST00000556922.1_Missense_Mutation_p.S52G					melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGGGCTGGTGAGCTTGGTGGA	0.642									Melanoma, Familial Clustering of				50	71					0	0	1	0	0	G	89985820	A	G	89985820	3	3	21	1	0	0	0	0	1	0	0	0	9412	304	11	4	156	4	MC1R	16	89985820	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	368819	89985820	368933	644	2065										
OR1A1	8383	broad.mit.edu	37	chr17	3119791	3119791	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcatctacagtctgagaaatCgggacatgaaggctgccctg	11	10	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:3119791C>T	ENST00000304094.1	+	1	877	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R293W(2)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						TCTGAGAAATCGGGACATGAA	0.468													56	92					0	0	1	0	0	T	3119791	C	T	3119791	3	4	21	1	0	0	0	0	1	0	0	0	10996	875	31	1	879	1	OR1A1	17	3119791	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08		3119791	78075419	645	2066										
TRPV3	162514	broad.mit.edu	37	chr17	3438974	3438974	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggctgcgatgtccccctgcCgccgctcgatggcgatgttc	14	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:3438974C>T	ENST00000301365.4	-	7	808	c.677G>A	c.(676-678)cGg>cAg	p.R226Q	TRPV3_ENST00000576742.1_Missense_Mutation_p.R226Q|TRPV3_ENST00000572519.1_Missense_Mutation_p.R226Q			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	226						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GTCCCCCTGCCGCCGCTCGAT	0.721													4	7					0	0	1	0	0	T	3438974	C	T	3438974	3	4	21	1	0	0	0	0	1	0	0	0	16657	652	23	1	1743	1	TRPV3	17	3438974	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	319183	3438974	77756236	646	2067										
UBE2G1	7326	broad.mit.edu	37	chr17	4200057	4200057	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaatttcattttaggaggtcGgaggggataatcttttggga	14	3	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4200057G>A	ENST00000396981.2	-	3	367	c.202C>T	c.(202-204)Cga>Tga	p.R68*	UBE2G1_ENST00000572484.1_5'UTR	NM_003342.4	NP_003333.1	P62253	UB2G1_HUMAN	ubiquitin-conjugating enzyme E2G 1	68					protein K48-linked ubiquitination|protein K63-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity	p.R68R(1)		large_intestine(2)|lung(4)|skin(1)	7						TTAGGAGGTCGGAGGGGATAA	0.353													101	170					0	0	1	0	0	A	4200057	G	A	4200057	4	1	21	1	0	0	0	0	0	1	0	0	16916	1124	39	1	322	1	UBE2G1	17	4200057	Nonsense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	761083	4200057	76995153	647	2068										
ALOX15	246	broad.mit.edu	37	chr17	4534907	4534907	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcgacgcttagatggccacActgttttccaccacgctggg	12	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4534907A>G	ENST00000570836.1	-	15	2073	c.1977T>C	c.(1975-1977)agT>agC	p.S659S	ALOX15_ENST00000545513.1_Silent_p.S681S|ALOX15_ENST00000293761.3_Silent_p.S659S|ALOX15_ENST00000574640.1_Silent_p.S620S			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	659	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	AGATGGCCACACTGTTTTCCA	0.577													40	59					0	0	1	0	0	G	4534907	A	G	4534907	2	3	21	1	0	0	0	0	0	0	0	1	534	156	6	4		4	ALOX15	17	4534907	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	334850	4534907	76660303	648	2069										
MINK1	50488	broad.mit.edu	37	chr17	4798393	4798393	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tagtgggtggagagggcactCggctcgaccagctgcagtac	16	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4798393C>T	ENST00000355280.6	+	25	3137	c.2941C>T	c.(2941-2943)Cgg>Tgg	p.R981W	MINK1_ENST00000453408.3_Missense_Mutation_p.R961W|MINK1_ENST00000347992.7_Missense_Mutation_p.R952W	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	981	Mediates interaction with RAP2A.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						AGAGGGCACTCGGCTCGACCA	0.597													21	36					0	0	1	0	0	T	4798393	C	T	4798393	3	4	21	1	0	0	0	0	1	0	0	0	9634	875	31	1	2806	1	MINK1	17	4798393	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	263486	4798393	76396817	649	2070										
SLC16A11	162515	broad.mit.edu	37	chr17	6946780	6946780	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttatcgcgaaggctgcggccGccaccacccagccccagccc	10	20	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:6946780G>A	ENST00000308009.1	-	1	462	c.125C>T	c.(124-126)gCg>gTg	p.A42V	SLC16A11_ENST00000447225.1_Missense_Mutation_p.A18V	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	42						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						GGCTGCGGCCGCCACCACCCA	0.697													15	11					0	0	1	0	0	A	6946780	G	A	6946780	3	1	21	1	0	0	0	0	1	0	0	0	14458	1087	38	1	1306	1	SLC16A11	17	6946780	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2148387	6946780	74248430	650	2071										
TMEM102	284114	broad.mit.edu	37	chr17	7339922	7339922	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcgccggtgtctttggaaaaAtcgcctagtgacgtttcagc	12	10	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:7339922A>C	ENST00000323206.1	+	3	897	c.624A>C	c.(622-624)aaA>aaC	p.K208N	TMEM102_ENST00000396568.1_Missense_Mutation_p.K208N|RP11-104H15.9_ENST00000570444.1_RNA|RP11-104H15.7_ENST00000575310.1_RNA	NM_178518.2	NP_848613.1	Q8N9M5	TM102_HUMAN	transmembrane protein 102	208					regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding			kidney(1)|lung(3)|skin(1)	5		Prostate(122;0.173)				CTTTGGAAAAATCGCCTAGTG	0.552													59	78					0	0	1	0	0	C	7339922	A	C	7339922	3	2	21	1	0	0	0	0	1	0	0	0	16076	98	4	4	630	4	TMEM102	17	7339922	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	393142	7339922	73855288	651	2072										
MYH10	4628	broad.mit.edu	37	chr17	8448900	8448900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ataggtagcttttgccaatgCttctactgcaaaatctgcct	7	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:8448900C>T	ENST00000360416.3	-	13	1435	c.1297G>A	c.(1297-1299)Gca>Aca	p.A433T	MYH10_ENST00000379980.4_Missense_Mutation_p.A439T|MYH10_ENST00000396239.1_Missense_Mutation_p.A423T|MYH10_ENST00000269243.4_Missense_Mutation_p.A423T	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	423	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TTTGCCAATGCTTCTACTGCA	0.398													20	26					0	0	1	0	0	T	8448900	C	T	8448900	3	4	21	1	0	0	0	0	1	0	0	0	10077	797	28	3	4783	3	MYH10	17	8448900	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1108978	8448900	72746310	652	2073										
GLP2R	9340	broad.mit.edu	37	chr17	9763352	9763352	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgaaggcctctacctccacAcgctgctggagcccacagtg	10	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:9763352A>G	ENST00000262441.5	+	7	1372	c.859A>G	c.(859-861)Acg>Gcg	p.T287A	GLP2R_ENST00000574745.1_Missense_Mutation_p.T107A	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	287					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	CTACCTCCACACGCTGCTGGA	0.572													11	25					0	0	1	0	0	G	9763352	A	G	9763352	3	3	21	1	0	0	0	0	1	0	0	0	6494	159	6	4	885	4	GLP2R	17	9763352	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1314452	9763352	71431858	653	2074										
MYH3	4621	broad.mit.edu	37	chr17	10555851	10555851	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacttgggggggttcatggcGtacacatcctctggtttgac	13	9	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:10555851G>A	ENST00000583535.1	-	4	321	c.234C>T	c.(232-234)taC>taT	p.Y78Y	MYH3_ENST00000226209.7_Silent_p.Y78Y	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	78	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.Y78Y(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GGTTCATGGCGTACACATCCT	0.468													45	51					0	0	1	0	0	A	10555851	G	A	10555851	2	1	21	1	0	0	0	0	0	0	0	1	10083	1140	40	1		1	MYH3	17	10555851	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	792499	10555851	70639359	654	2075										
DNAH9	1770	broad.mit.edu	37	chr17	11725897	11725897	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtcagcctccgcttcttgcAgaacacagagggcattgagg	12	11	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:11725897A>C	ENST00000262442.3	+	47	9061	c.8993A>C	c.(8992-8994)cAg>cCg	p.Q2998P	DNAH9_ENST00000454412.2_Missense_Mutation_p.Q2998P	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2998	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGCTTCTTGCAGAACACAGAG	0.522													68	92					0	0	1	0	0	C	11725897	A	C	11725897	3	2	21	1	0	0	0	0	1	0	0	0	4635	188	7	4	9179	4	DNAH9	17	11725897	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1170046	11725897	69469313	655	2076										
ELAC2	60528	broad.mit.edu	37	chr17	12897743	12897744	+	Splice_Site	DEL	TG	TG	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actgaccggcctttgctaccTgtgtgtcttttccactgctt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:12897743_12897744delTG	ENST00000338034.4	-	22	2345_2346	c.2108_splice	c.e22+1	p.HS702_splice	ELAC2_ENST00000426905.3_Splice_Site_p.HS662_splice|ELAC2_ENST00000395962.2_Splice_Site_p.HS683_splice	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	702					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						CTTTGCTACCTGTGTGTCTTTT	0.564													157	289	---	---	---	---						-	12897744	TG	-	12897743	8	5	21	1	0	1	0	1	0	0	1	0	5075	1594	55	0	385	0	ELAC2	17	12897743	Splice_Site	DEL	TG	TCGA-N7-A4Y0-01A-12D-A28R-08	1171846	12897743	68297467	656	2077										
CCDC144A	9720	broad.mit.edu	37	chr17	16593988	16593988	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagagctgcccggtcgggcGacgtccctggggtggagcac	17	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:16593988G>A	ENST00000443444.2	+	1	414	c.274G>A	c.(274-276)Gac>Aac	p.D92N	CCDC144A_ENST00000360524.8_Missense_Mutation_p.D92N|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.D92N|CCDC144A_ENST00000456009.1_Missense_Mutation_p.D92N|CCDC144A_ENST00000340621.5_Missense_Mutation_p.D92N|CCDC144A_ENST00000436374.1_3'UTR|CCDC144A_ENST00000399273.1_Missense_Mutation_p.D92N			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	92																	CCGGTCGGGCGACGTCCCTGG	0.642													94	141					0	0	1	0	0	A	16593988	G	A	16593988	3	1	21	1	0	0	0	0	1	0	0	0	2795	1058	37	1	276	1	CCDC144A	17	16593988	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3696245	16593988	64601222	657	2078										
RAI1	10743	broad.mit.edu	37	chr17	17698653	17698653	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgggcttccaggaggaggaCccccctggggagaaggtggc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:17698653delC	ENST00000353383.1	+	3	2860	c.2391delC	c.(2389-2391)gafs	p.D797fs	RAI1_ENST00000261641.6_Frame_Shift_Del_p.D797fs	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	797						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		AGGAGGAGGACCCCCCTGGGG	0.667													21	34	---	---	---	---						-	17698653	C	-	17698653	7	5	21	1	0	1	0	1	0	0	0	0	13058	506	18	0	2393	0	RAI1	17	17698653	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1104665	17698653	63496557	658	2079										
LGALS9	3965	broad.mit.edu	37	chr17	25976006	25976006	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agctgacccatgtgcagacaTaggcggcttcctggccctgg	13	13	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:25976006T>C	ENST00000395473.2	+	11	2534	c.1066T>C	c.(1066-1068)Tag>Cag	p.*356Q	LGALS9_ENST00000413914.2_3'UTR|LGALS9_ENST00000313648.6_3'UTR|LGALS9_ENST00000310394.5_Nonstop_Mutation_p.*312Q|LGALS9_ENST00000302228.5_Nonstop_Mutation_p.*324Q	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		TGTGCAGACATAGGCGGCTTC	0.627													72	121					0	0	1	0	0	C	25976006	T	C	25976006	4	2	21	1	0	0	0	0	0	0	0	0	8787	1419	49	4	1108	4	LGALS9	17	25976006	Nonstop_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	8277353	25976006	55219204	659	2080										
NLK	51701	broad.mit.edu	37	chr17	26519194	26519195	+	Frame_Shift_Del	DEL	CT	CT	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagaaaggaaacagagtgcCtctctgcatcaaccctcagt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:26519194_26519195delCT	ENST00000407008.3	+	10	2202_2203	c.1484_1485delCT	c.(1483-1485)cfs	p.P495fs		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	495					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		AACAGAGTGCCTCTCTGCATCA	0.376													10	12	---	---	---	---						-	26519195	CT	-	26519194	7	5	21	1	0	1	0	1	0	0	0	0	10512	681	24	0	1522	0	NLK	17	26519194	Frame_Shift_Del	DEL	CT	TCGA-N7-A4Y0-01A-12D-A28R-08	543188	26519194	54676016	660	2081										
PROCA1	147011	broad.mit.edu	37	chr17	27031790	27031790	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtggcggacacagtcagaggCgaaagggtagatgatgtgcc	17	7	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:27031790C>T	ENST00000301039.2	-	2	356	c.163G>A	c.(163-165)Gcc>Acc	p.A55T	PROCA1_ENST00000581289.1_Intron|PROCA1_ENST00000579650.1_5'UTR|PROCA1_ENST00000439862.3_Missense_Mutation_p.A57T	NM_152465.1	NP_689678.1	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	83					lipid catabolic process		calcium ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(4)|ovary(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					CAGTCAGAGGCGAAAGGGTAG	0.592													31	44					0	0	1	0	0	T	27031790	C	T	27031790	3	4	21	1	0	0	0	0	1	0	0	0	12597	768	27	1	859	1	PROCA1	17	27031790	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	512596	27031790	54163420	661	2082										
ZNF207	7756	broad.mit.edu	37	chr17	30694992	30694992	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctacacttacaacaactagtGcaaccagtaagttgatccat	5	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:30694992G>A	ENST00000394670.4	+	10	1292	c.1123G>A	c.(1123-1125)Gca>Aca	p.A375T	ZNF207_ENST00000577908.1_Missense_Mutation_p.A375T|ZNF207_ENST00000394673.2_Missense_Mutation_p.A344T|ZNF207_ENST00000342555.6_Missense_Mutation_p.A378T|ZNF207_ENST00000341711.6_Missense_Mutation_p.A276T|ZNF207_ENST00000321233.6_Missense_Mutation_p.A359T	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	359						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			AACAACTAGTGCAACCAGTAA	0.398													37	62					0	0	1	0	0	A	30694992	G	A	30694992	3	1	21	1	0	0	0	0	1	0	0	0	17822	1319	46	3	1161	3	ZNF207	17	30694992	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3663202	30694992	50500218	662	2083										
SPACA3	124912	broad.mit.edu	37	chr17	31323957	31323957	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgggatcttccagatcaacaGccggaggtggtgcagcaacc	13	12	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:31323957G>A	ENST00000580599.1	+	4	642	c.233G>A	c.(232-234)aGc>aAc	p.S78N	SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000269053.3_Missense_Mutation_p.S147N|SPACA3_ENST00000394638.1_Missense_Mutation_p.S44N			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	147					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			CAGATCAACAGCCGGAGGTGG	0.607													61	72					0	0	1	0	0	A	31323957	G	A	31323957	3	1	21	1	0	0	0	0	1	0	0	0	15026	971	34	3	450	3	SPACA3	17	31323957	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	628965	31323957	49871253	663	2084										
GAS2L2	246176	broad.mit.edu	37	chr17	34074161	34074161	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tatatgtcttccagtccacaGggggtggtgggctctgtgag	15	8	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:34074161G>T	ENST00000254466.6	-	5	986	c.959C>A	c.(958-960)cCt>cAt	p.P320H	GAS2L2_ENST00000587565.1_Missense_Mutation_p.P304H	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	320					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCAGTCCACAGGGGGTGGTGG	0.652													70	98					4.79706e-38	5.40055e-38	1	1	0	T	34074161	G	T	34074161	3	4	21	1	0	0	0	0	1	0	0	0	6286	1000	35	5	1691	5	GAS2L2	17	34074161	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2750204	34074161	47121049	664	2085										
TAF15	8148	broad.mit.edu	37	chr17	34171886	34171886	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctatggaggagacagaagccGggggggctatggaggagacc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:34171886delG	ENST00000588240.1	+	15	1698	c.1583delG	c.(1582-1584)cgfs	p.R528fs	TAF15_ENST00000311979.3_Frame_Shift_Del_p.R525fs|TAF15_ENST00000592237.1_Frame_Shift_Del_p.G334fs	NM_003487.3|NM_139215.2	NP_003478.1|NP_631961.1	Q92804	RBP56_HUMAN	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	528	21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.|Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	lung(1)|ovary(1)|skin(2)|stomach(1)	5		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		gACAGAAGCCGGGGGGGCTAT	0.612			T	"TEC, CHN1, ZNF384"	"extraskeletal myxoid chondrosarcomas, ALL"								44	63	---	---	---	---						-	34171886	G	-	34171886	7	5	21	1	0	1	0	1	0	0	0	0	15574	1116	39	0	1641	0	TAF15	17	34171886	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	97725	34171886	47023324	665	2086										
GRB7	2886	broad.mit.edu	37	chr17	37899524	37899524	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcgtcttccggaaaaacttCgccaagtacgaactgttcaa	7	11	2	0	rs145171655		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:37899524C>T	ENST00000309156.4	+	5	812	c.555C>T	c.(553-555)ttC>ttT	p.F185F	GRB7_ENST00000445327.2_Silent_p.F208F|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394209.2_Silent_p.F185F|GRB7_ENST00000394211.3_Silent_p.F185F|GRB7_ENST00000309185.3_Silent_p.F185F|GRB7_ENST00000394204.1_Silent_p.F185F	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	185	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGAAAAACTTCGCCAAGTACG	0.617													50	51					0	0	1	0	0	T	37899524	C	T	37899524	2	4	21	1	0	0	0	0	0	0	0	1	6799	883	31	1		1	GRB7	17	37899524	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3727638	37899524	43295686	666	2087										
KRT222	125113	broad.mit.edu	37	chr17	38818272	38818272	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcctcttcatctttgtccaTttttttgcttatgtcttctt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:38818272delT	ENST00000476049.1	-	2	162	c.121delA	c.(121-123)tgfs	p.M41fs	KRT222_ENST00000394052.3_Frame_Shift_Del_p.M41fs			Q8N1A0	KT222_HUMAN	keratin 222	41						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						TCTTTGTCCATTTTTTTGCTT	0.428													65	97	---	---	---	---						-	38818272	T	-	38818272	7	5	21	1	0	1	0	1	0	0	0	0	8501	1493	52	0	786	0	KRT222	17	38818272	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	918748	38818272	42376938	667	2088										
TMEM106A	113277	broad.mit.edu	37	chr17	41369782	41369782	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgtggactgccgaggaaacGcatctgtgccccaccagctg	12	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:41369782G>A	ENST00000331615.3	+	9	988	c.751G>A	c.(751-753)Gca>Aca	p.A251T	TMEM106A_ENST00000536052.1_Missense_Mutation_p.A204T|TMEM106A_ENST00000541594.1_Missense_Mutation_p.A203T|TMEM106A_ENST00000588659.1_Missense_Mutation_p.A251T|LINC00854_ENST00000427995.1_RNA	NM_145041.1	NP_659478.1	Q96A25	T106A_HUMAN	transmembrane protein 106A	251						integral to membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		CCGAGGAAACGCATCTGTGCC	0.577													127	183					0	0	1	0	0	A	41369782	G	A	41369782	3	1	21	1	0	0	0	0	1	0	0	0	16079	1087	38	1	777	1	TMEM106A	17	41369782	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2551510	41369782	39825428	668	2089										
ATXN7L3	56970	broad.mit.edu	37	chr17	42272160	42272160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agggcccgagaaaataaatcCgtacggttcgcctctgctca	10	12	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:42272160C>T	ENST00000389384.4	-	10	1021	c.713G>A	c.(712-714)cGg>cAg	p.R238Q	ATXN7L3_ENST00000593073.1_5'UTR|ATXN7L3_ENST00000454077.2_Missense_Mutation_p.R245Q	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	238	SCA7.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AAAATAAATCCGTACGGTTCG	0.577													12	21					0	0	1	0	0	T	42272160	C	T	42272160	3	4	21	1	0	0	0	0	1	0	0	0	1216	652	23	1	342	1	ATXN7L3	17	42272160	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	902378	42272160	38923050	669	2090										
ARHGAP27	201176	broad.mit.edu	37	chr17	43473179	43473179	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcagcgagcgcaccaagtcaCgcacacagcggctgcgccgg	14	16	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:43473179C>A	ENST00000532038.1	-	15	1892	c.1757G>T	c.(1756-1758)cGt>cTt	p.R586L	ARHGAP27_ENST00000455881.1_Missense_Mutation_p.R467L|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.R440L|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.R808L|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.R781L|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.R786L|ARHGAP27_ENST00000376922.2_Missense_Mutation_p.R467L			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	808	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CACCAAGTCACGCACACAGCG	0.692													10	13					0.00621372	0.00627814	1	1	0	A	43473179	C	A	43473179	3	1	21	1	0	0	0	0	1	0	0	0	873	536	19	5	254	5	ARHGAP27	17	43473179	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1201019	43473179	37722031	670	2091										
ARHGAP27	201176	broad.mit.edu	37	chr17	43474152	43474152	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccacggggcccagggcgggCgcggctgccgcggggaaagg	21	14	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:43474152C>T	ENST00000532038.1	-	11	1425	c.1290G>A	c.(1288-1290)gcG>gcA	p.A430A	ARHGAP27_ENST00000455881.1_Silent_p.A311A|ARHGAP27_ENST00000528384.1_Silent_p.A284A|ARHGAP27_ENST00000428638.1_Silent_p.A652A|ARHGAP27_ENST00000442348.1_Silent_p.A625A|ARHGAP27_ENST00000532891.2_Silent_p.A630A|ARHGAP27_ENST00000376922.2_Silent_p.A311A			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	652	WW 3.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CCAGGGCGGGCGCGGCTGCCG	0.716													9	25					0	0	1	0	0	T	43474152	C	T	43474152	2	4	21	1	0	0	0	0	0	0	0	1	873	755	27	1		1	ARHGAP27	17	43474152	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	973	43474152	37721058	671	2092										
HOXB1	3211	broad.mit.edu	37	chr17	46607839	46607839	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cggtctgctcgttcccataaGggggatgctgcggaggatat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:46607839delG	ENST00000239174.6	-	1	520	c.428delC	c.(427-429)ctfs	p.P143fs	HOXB1_ENST00000577092.1_Frame_Shift_Del_p.P143fs	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	143						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTTCCCATAAGGGGGATGCTG	0.617													27	53	---	---	---	---						-	46607839	G	-	46607839	7	5	21	1	0	1	0	1	0	0	0	0	7339	1000	35	0	485	0	HOXB1	17	46607839	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3133687	46607839	34587371	672	2093										
B4GALNT2	124872	broad.mit.edu	37	chr17	47243577	47243577	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacgaggagaccaagattgaGgtgctggtggatgtcctgga	16	6	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:47243577G>T	ENST00000300404.2	+	9	1295	c.1236G>T	c.(1234-1236)gaG>gaT	p.E412D	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.E326D|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.E352D	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	412					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CCAAGATTGAGGTGCTGGTGG	0.502													31	38					5.77227e-19	6.33577e-19	1	1	0	T	47243577	G	T	47243577	3	4	21	1	0	0	0	0	1	0	0	0	1265	991	35	5	1288	5	B4GALNT2	17	47243577	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	635738	47243577	33951633	673	2094										
BCAS3	54828	broad.mit.edu	37	chr17	58767096	58767096	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aaaggagaaaatagtctgggTcagatttgaaaatgcagatt	11	3	2	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:58767096T>C	ENST00000589222.1	+	4	256	c.188T>C	c.(187-189)gTc>gCc	p.V63A	BCAS3_ENST00000407086.3_Missense_Mutation_p.V63A|BCAS3_ENST00000408905.3_Missense_Mutation_p.V63A|BCAS3_ENST00000588462.1_Missense_Mutation_p.V63A|BCAS3_ENST00000390652.5_Missense_Mutation_p.V63A			Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3	63						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			ATAGTCTGGGTCAGATTTGAA	0.328													19	30					0	0	1	0	0	C	58767096	T	C	58767096	3	2	21	1	0	0	0	0	1	0	0	0	1350	1667	58	4	198	4	BCAS3	17	58767096	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	11523519	58767096	22428114	674	2095										
MED13	9969	broad.mit.edu	37	chr17	60059865	60059865	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atgttcagcagaggtagcccTgagagcttcaaaacgttttt	10	8	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:60059865T>C	ENST00000397786.2	-	16	3575	c.3499A>G	c.(3499-3501)Agg>Ggg	p.R1167G		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1167					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GAGGTAGCCCTGAGAGCTTCA	0.348													43	55					0	0	1	0	0	C	60059865	T	C	60059865	3	2	21	1	0	0	0	0	1	0	0	0	9479	1579	55	4	3085	4	MED13	17	60059865	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1292769	60059865	21135345	675	2096										
ABCA6	23460	broad.mit.edu	37	chr17	67081776	67081776	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcctcactacctctccagcaGttggctttgtgatcccagat	7	14	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:67081776G>A	ENST00000284425.2	-	31	4193	c.4019C>T	c.(4018-4020)aCt>aTt	p.T1340I	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1340	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CTCTCCAGCAGTTGGCTTTGT	0.358													13	15					0	0	1	0	0	A	67081776	G	A	67081776	3	1	21	1	0	0	0	0	1	0	0	0	36	1029	36	3	870	3	ABCA6	17	67081776	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7021911	67081776	14113434	676	2097										
GPR142	350383	broad.mit.edu	37	chr17	72368690	72368690	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acagccagagggcatggcggCgaagcctgtgatggagcctc	16	11	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:72368690C>T	ENST00000335666.4	+	4	1388	c.1340C>T	c.(1339-1341)gCg>gTg	p.A447V		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	447						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity	p.A447E(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						GGCATGGCGGCGAAGCCTGTG	0.617													14	28					0	0	1	0	0	T	72368690	C	T	72368690	3	4	21	1	0	0	0	0	1	0	0	0	6689	768	27	1	1354	1	GPR142	17	72368690	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5286914	72368690	8826520	677	2098										
CD300A	11314	broad.mit.edu	37	chr17	72470735	72470735	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcaacaatcacaactgcattTccacctgtatcatccactac	2	15	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:72470735T>C	ENST00000360141.3	+	3	732	c.444T>C	c.(442-444)ttT>ttC	p.F148F	CD300A_ENST00000392625.3_Silent_p.F35F|CD300A_ENST00000310828.5_Silent_p.F35F|CD300A_ENST00000361933.3_Intron|CD300A_ENST00000577511.1_Silent_p.F18F	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	148					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						CAACTGCATTTCCACCTGTAT	0.532													49	69					0	0	1	0	0	C	72470735	T	C	72470735	2	2	21	1	0	0	0	0	0	0	0	1	3018	1780	62	4		4	CD300A	17	72470735	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	102045	72470735	8724475	678	2099										
RHBDF2	79651	broad.mit.edu	37	chr17	74469406	74469406	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tattcccgggtggtgatctcAcagctaagggggtggtgagg	17	7	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:74469406A>G	ENST00000591885.1	-	16	2287	c.1737T>C	c.(1735-1737)tgT>tgC	p.C579C	RHBDF2_ENST00000389760.4_Silent_p.C579C|RHBDF2_ENST00000313080.4_Silent_p.C608C			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	608					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						TGGTGATCTCACAGCTAAGGG	0.597													17	13					0	0	1	0	0	G	74469406	A	G	74469406	2	3	21	1	0	0	0	0	0	0	0	1	13369	157	6	4		4	RHBDF2	17	74469406	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1998671	74469406	6725804	679	2100										
DNAH17	8632	broad.mit.edu	37	chr17	76425217	76425217	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttaccttgtagtccaggttGggggggatctgaaagccggg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:76425217delG	ENST00000389840.5	-	76	12496	c.12372delC	c.(12370-12372)ccfs	p.P4124fs	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Frame_Shift_Del_p.P4125fs					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTCCAGGTTGGGGGGGATCT	0.582													42	132	---	---	---	---						-	76425217	G	-	76425217	7	5	21	1	0	1	0	1	0	0	0	0	4629	1335	47	0	1022	0	DNAH17	17	76425217	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1955811	76425217	4769993	680	2101										
CANT1	124583	broad.mit.edu	37	chr17	76989847	76989847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgccccgacgtggctcacagCgatgtcgccgaagtcagggg	15	14	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:76989847C>T	ENST00000302345.2	-	4	1485	c.991G>A	c.(991-993)Gct>Act	p.A331T	CANT1_ENST00000591773.1_Missense_Mutation_p.A331T|CANT1_ENST00000392446.5_Missense_Mutation_p.A331T	NM_001159773.1|NM_138793.3	NP_001153245.1|NP_620148.1	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	331					positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity		CANT1/ETV4(3)	cervix(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			TGGCTCACAGCGATGTCGCCG	0.657			T	ETV4	prostate								28	39					0	0	1	0	0	T	76989847	C	T	76989847	3	4	21	1	0	0	0	0	1	0	0	0	2635	768	27	1	218	1	CANT1	17	76989847	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	564630	76989847	4205363	681	2102										
TBC1D16	125058	broad.mit.edu	37	chr17	77984212	77984212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgcaagcaggctgcgaggCtggctgggcaccatccaccc	14	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:77984212C>T	ENST00000310924.2	-	3	641	c.526G>A	c.(526-528)Gcc>Acc	p.A176T		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	176						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GGCTGCGAGGCTGGCTGGGCA	0.706													6	27					0	0	1	0	0	T	77984212	C	T	77984212	3	4	21	1	0	0	0	0	1	0	0	0	15661	797	28	3	1817	3	TBC1D16	17	77984212	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	994365	77984212	3210998	682	2103										
ARL16	339231	broad.mit.edu	37	chr17	79650090	79650090	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actggaccagatggggcccaTgcaccccccaagctcccgga	11	17	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:79650090T>C	ENST00000397498.4	-	3	357	c.259A>G	c.(259-261)Atg>Gtg	p.M87V	ARL16_ENST00000573392.1_Intron|ARL16_ENST00000574938.1_Intron|ARL16_ENST00000576135.1_Start_Codon_SNP_p.M1V|ARL16_ENST00000570561.1_Start_Codon_SNP_p.M1V	NM_001040025.1	NP_001035114.1	Q0P5N6	ARL16_HUMAN	ADP-ribosylation factor-like 16	87							GTP binding			central_nervous_system(1)|endometrium(1)|lung(4)|skin(1)	7	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			ATGGGGCCCATGCACCCCCCA	0.488													22	207					0	0	1	0	0	C	79650090	T	C	79650090	3	2	21	1	0	0	0	0	1	0	0	0	929	1464	51	4	346	4	ARL16	17	79650090	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1665878	79650090	1545120	683	2104										
RAC3	5881	broad.mit.edu	37	chr17	79991680	79991680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccgcccccagtgaagaagcCggggaagaagtgcaccgtct	13	14	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:79991680C>T	ENST00000306897.4	+	6	692	c.554C>T	c.(553-555)cCg>cTg	p.P185L		NM_005052.2	NP_005043.1	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	185					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding			NS(1)|kidney(1)|skin(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GTGAAGAAGCCGGGGAAGAAG	0.652													17	7					0	0	1	0	0	T	79991680	C	T	79991680	3	4	21	1	0	0	0	0	1	0	0	0	13027	652	23	1	576	1	RAC3	17	79991680	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	341590	79991680	1203530	684	2105										
FASN	2194	broad.mit.edu	37	chr17	80049428	80049428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccaaaggagttgatgcccaCgttgccgccacggacgggca	14	13	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:80049428C>T	ENST00000306749.2	-	9	1380	c.1162G>A	c.(1162-1164)Gtg>Atg	p.V388M		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	388	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TTGATGCCCACGTTGCCGCCA	0.682													10	9					0	0	1	0	0	T	80049428	C	T	80049428	3	4	21	1	0	0	0	0	1	0	0	0	5715	536	19	1	6513	1	FASN	17	80049428	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	57748	80049428	1145782	685	2106										
PTPRM	5797	broad.mit.edu	37	chr18	8114820	8114820	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agactgtgtccaagtggccaCaaaaggtaggttgaaattgt	12	6	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:8114820C>T	ENST00000332175.8	+	13	3199	c.2162C>T	c.(2161-2163)aCa>aTa	p.T721I	PTPRM_ENST00000400053.4_Missense_Mutation_p.T659I|PTPRM_ENST00000444013.1_Missense_Mutation_p.T508I|PTPRM_ENST00000400060.4_Missense_Mutation_p.T721I|PTPRM_ENST00000580170.1_Missense_Mutation_p.T721I	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	721					homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CAAGTGGCCACAAAAGGTAGG	0.299													19	15					0	0	1	0	0	T	8114820	C	T	8114820	3	4	21	1	0	0	0	0	1	0	0	0	12857	478	17	3	2212	3	PTPRM	18	8114820	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08		8114820	69962428	686	2107										
MC2R	0	broad.mit.edu	37	chr18	13885199	13885199	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagaggacaaacagggagtCgatgatgtcatcggctgtgg	17	6	1	2	rs104894661		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:13885199C>T	ENST00000327606.3	-	2	499	c.319G>A	c.(319-321)Gac>Aac	p.D107N		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	107			D -> N (in GCCD1).		G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	AACAGGGAGTCGATGATGTCA	0.498													21	38					0	0	1	0	0	T	13885199	C	T	13885199	3	4	21	1	0	0	0	0	1	0	0	0	9413	884	31	1	578	1	MC2R	18	13885199	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5770379	13885199	64192049	687	2108										
LAMA3	3909	broad.mit.edu	37	chr18	21484616	21484616	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccatcaaagcggccgaggaCgcagccaacagggctgccag	14	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:21484616C>T	ENST00000313654.9	+	51	6814	c.6573C>T	c.(6571-6573)gaC>gaT	p.D2191D	LAMA3_ENST00000269217.6_Silent_p.D582D|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000399516.3_Silent_p.D2135D|LAMA3_ENST00000587184.1_Silent_p.D526D	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2191	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGCCGAGGACGCAGCCAACA	0.582													14	17					0	0	1	0	0	T	21484616	C	T	21484616	2	4	21	1	0	0	0	0	0	0	0	1	8645	535	19	1		1	LAMA3	18	21484616	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7599417	21484616	56592632	688	2109										
MAPRE2	10982	broad.mit.edu	37	chr18	32720278	32720278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagggccacacagaagagcCggaagcagaggagcaagccc	16	11	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:32720278C>T	ENST00000436190.2	+	8	1167	c.893C>T	c.(892-894)cCg>cTg	p.P298L	MAPRE2_ENST00000538170.2_Missense_Mutation_p.P257L|MAPRE2_ENST00000589699.1_Missense_Mutation_p.P267L|MAPRE2_ENST00000300249.5_Missense_Mutation_p.P310L|MAPRE2_ENST00000413393.1_Missense_Mutation_p.P267L	NM_001143827.2	NP_001137299.1	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family, member 2	310	APC-binding.|DCTN1-binding.|EB1 C-terminal.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9						ACAGAAGAGCCGGAAGCAGAG	0.597													9	16					0	0	1	0	0	T	32720278	C	T	32720278	3	4	21	1	0	0	0	0	1	0	0	0	9344	652	23	1	1049	1	MAPRE2	18	32720278	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	11235662	32720278	45356970	689	2110										
MOCOS	55034	broad.mit.edu	37	chr18	33800116	33800116	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgagtcagaagcaggaaccCcggctctgcctgatccagcc	11	15	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:33800116C>T	ENST00000261326.5	+	9	1917	c.1896C>T	c.(1894-1896)ccC>ccT	p.P632P		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	632					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	AGCAGGAACCCCGGCTCTGCC	0.532													25	48					0	0	1	0	0	T	33800116	C	T	33800116	2	4	21	1	0	0	0	0	0	0	0	1	9737	610	22	3		3	MOCOS	18	33800116	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1079838	33800116	44277132	690	2111										
PIK3C3	5289	broad.mit.edu	37	chr18	39575909	39575909	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccggagtttaagaagtggacCttctgaccacgatctgaaac	10	10	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:39575909C>A	ENST00000262039.4	+	8	928	c.842C>A	c.(841-843)cCt>cAt	p.P281H	PIK3C3_ENST00000398870.3_Missense_Mutation_p.P218H	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	281					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						AGAAGTGGACCTTCTGACCAC	0.348										TSP Lung(28;0.18)			37	49					4.67007e-22	5.17127e-22	1	1	0	A	39575909	C	A	39575909	3	1	21	1	0	0	0	0	1	0	0	0	11959	681	24	5	872	5	PIK3C3	18	39575909	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	5775793	39575909	38501339	691	2112										
RNF165	494470	broad.mit.edu	37	chr18	44036491	44036491	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctctcttccagacgcctaccCtgtatgcatctctttcacca	4	17	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:44036491C>A	ENST00000269439.7	+	8	984	c.933C>A	c.(931-933)ccC>ccA	p.P311P	RNF165_ENST00000543885.1_Silent_p.P119P	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	311							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		GACGCCTACCCTGTATGCATC	0.592													52	70					1.17673e-23	1.30632e-23	1	1	0	A	44036491	C	A	44036491	2	1	21	1	0	0	0	0	0	0	0	1	13507	668	24	5		5	RNF165	18	44036491	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	4460582	44036491	34040757	692	2113										
CXXC1	30827	broad.mit.edu	37	chr18	47811722	47811722	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggaagtacttgtacgattcCtgtgccggcaggaggaaggc	16	8	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:47811722C>A	ENST00000285106.6	-	6	1354		c.e6-1		CXXC1_ENST00000412036.2_Splice_Site|CXXC1_ENST00000589940.1_Splice_Site	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1						histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TGTACGATTCCTGTGCCGGCA	0.672													25	42					2.44723e-14	2.62695e-14	1	1	0	A	47811722	C	A	47811722	5	1	21	1	0	0	0	0	0	0	1	0	4120	695	24	5	1383	5	CXXC1	18	47811722	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3775231	47811722	30265526	693	2114										
TCF4	6925	broad.mit.edu	37	chr18	52896149	52896149	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcaggagcttggtctggggcTtgtcactcttgaggtggagc	16	8	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:52896149T>G	ENST00000354452.3	-	18	2419	c.1808A>C	c.(1807-1809)aAg>aCg	p.K603T	TCF4_ENST00000561992.1_Missense_Mutation_p.K469T|TCF4_ENST00000561831.3_Missense_Mutation_p.K439T|TCF4_ENST00000398339.1_Missense_Mutation_p.K705T|TCF4_ENST00000537578.1_Missense_Mutation_p.K579T|TCF4_ENST00000565018.2_Missense_Mutation_p.K603T|TCF4_ENST00000540999.1_Missense_Mutation_p.K575T|TCF4_ENST00000566279.1_Missense_Mutation_p.K543T|TCF4_ENST00000537856.3_Missense_Mutation_p.K469T|TCF4_ENST00000457482.3_Missense_Mutation_p.K443T|TCF4_ENST00000567880.1_Missense_Mutation_p.K539T|TCF4_ENST00000564228.1_Missense_Mutation_p.K528T|TCF4_ENST00000568673.1_Missense_Mutation_p.K579T|TCF4_ENST00000568740.1_Missense_Mutation_p.K574T|TCF4_ENST00000356073.4_Missense_Mutation_p.K599T|TCF4_ENST00000570287.2_Missense_Mutation_p.K439T|TCF4_ENST00000564403.2_Missense_Mutation_p.K609T|TCF4_ENST00000570177.2_Missense_Mutation_p.K469T|TCF4_ENST00000544241.2_Missense_Mutation_p.K532T|TCF4_ENST00000564999.1_Missense_Mutation_p.K599T|TCF4_ENST00000566286.1_Missense_Mutation_p.K596T|TCF4_ENST00000543082.1_Missense_Mutation_p.K557T	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	599	Helix-loop-helix motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GGTCTGGGGCTTGTCACTCTT	0.617													35	63					0	0	1	0	0	G	52896149	T	G	52896149	3	3	21	1	0	0	0	0	1	0	0	0	15754	1609	56	4	215	4	TCF4	18	52896149	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	5084427	52896149	25181099	694	2115										
CDH20	28316	broad.mit.edu	37	chr18	59221723	59221723	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggccaagctctacgaggccgAcatggacctgtgggcaccgc	14	14	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:59221723A>G	ENST00000262717.4	+	12	2599	c.2201A>G	c.(2200-2202)gAc>gGc	p.D734G	CDH20_ENST00000538374.1_Missense_Mutation_p.D734G|CDH20_ENST00000536675.2_Missense_Mutation_p.D734G			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	734					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TACGAGGCCGACATGGACCTG	0.647													10	12					0	0	1	0	0	G	59221723	A	G	59221723	3	3	21	1	0	0	0	0	1	0	0	0	3128	275	10	4	2243	4	CDH20	18	59221723	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	6325574	59221723	18855525	695	2116										
CDH7	1005	broad.mit.edu	37	chr18	63525089	63525089	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acacagacttggagagatacTtcaatattgatgccaacagt	8	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:63525089T>G	ENST00000536984.2	+	8	1967	c.1273T>G	c.(1273-1275)Ttc>Gtc	p.F425V	CDH7_ENST00000397968.2_Missense_Mutation_p.F425V|CDH7_ENST00000323011.3_Missense_Mutation_p.F425V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	425	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GGAGAGATACTTCAATATTGA	0.388													5	109					0	0	1	0	0	G	63525089	T	G	63525089	3	3	21	1	0	0	0	0	1	0	0	0	3137	1609	56	4	1299	4	CDH7	18	63525089	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4303366	63525089	14552159	696	2117										
CDH7	1005	broad.mit.edu	37	chr18	63547798	63547798	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgcactgagaaacctcaacGtcatccgagacaccaagacc	7	15	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:63547798G>A	ENST00000397968.2	+	12	2452	c.2026G>A	c.(2026-2028)Gtc>Atc	p.V676I	CDH7_ENST00000323011.3_Missense_Mutation_p.V676I	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	676					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AAACCTCAACGTCATCCGAGA	0.483													36	46					0	0	1	0	0	A	63547798	G	A	63547798	3	1	21	1	0	0	0	0	1	0	0	0	3137	1145	40	1	2068	1	CDH7	18	63547798	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	22709	63547798	14529450	697	2118										
PQLC1	80148	broad.mit.edu	37	chr18	77703350	77703350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtaaaggagcggcgcctggCgttgagctcgttggccacac	15	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:77703350C>T	ENST00000397778.2	-	3	498	c.316G>A	c.(316-318)Gcc>Acc	p.A106T	PQLC1_ENST00000590381.1_Missense_Mutation_p.A106T|PQLC1_ENST00000409073.1_Missense_Mutation_p.A23T|PQLC1_ENST00000357575.4_Missense_Mutation_p.A106T	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	106						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		CGGCGCCTGGCGTTGAGCTCG	0.582													116	142					0	0	1	0	0	T	77703350	C	T	77703350	3	4	21	1	0	0	0	0	1	0	0	0	12466	768	27	1	515	1	PQLC1	18	77703350	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	14155552	77703350	373898	698	2119										
ABCA7	10347	broad.mit.edu	37	chr19	1046869	1046869	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggatctactccgtgacacTgacagtgaaggccgtggtgc	13	11	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:1046869T>C	ENST00000263094.6	+	14	1922	c.1691T>C	c.(1690-1692)cTg>cCg	p.L564P	ABCA7_ENST00000435683.2_Missense_Mutation_p.L426P|ABCA7_ENST00000433129.1_Missense_Mutation_p.L564P|ABCA7_ENST00000533574.1_Intron	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	564					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGTGACACTGACAGTGAAG	0.687													4	2					0	0	1	0	0	C	1046869	T	C	1046869	3	2	21	1	0	0	0	0	1	0	0	0	37	1580	55	4	1741	4	ABCA7	19	1046869	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08		1046869	58082114	699	2120										
KLF16	83855	broad.mit.edu	37	chr19	1854672	1854672	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggagaagcgcttctcgcccGtgtgcgtccggtggtggcgg	18	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:1854672G>A	ENST00000250916.4	-	2	615	c.545C>T	c.(544-546)aCg>aTg	p.T182M	KLF16_ENST00000592313.1_5'UTR	NM_031918.3	NP_114124.1	Q9BXK1	KLF16_HUMAN	Kruppel-like factor 16	182						nucleus	DNA binding|zinc ion binding			lung(1)	1		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTCGCCCGTGTGCGTCCG	0.687													34	44					0	0	1	0	0	A	1854672	G	A	1854672	3	1	21	1	0	0	0	0	1	0	0	0	8386	1145	40	1	217	1	KLF16	19	1854672	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	807803	1854672	57274311	700	2121										
KDM4B	23030	broad.mit.edu	37	chr19	5131092	5131092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcctcttcccacagaggacGggaggggcaagctgcggcca	14	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:5131092G>A	ENST00000159111.4	+	12	1539	c.1321G>A	c.(1321-1323)Ggg>Agg	p.G441R	KDM4B_ENST00000536461.1_Missense_Mutation_p.G475R	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	441					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CACAGAGGACGGGAGGGGCAA	0.652													6	8					0	0	1	0	0	A	5131092	G	A	5131092	3	1	21	1	0	0	0	0	1	0	0	0	8172	1116	39	1	1359	1	KDM4B	19	5131092	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3276420	5131092	53997891	701	2122										
SAFB	6294	broad.mit.edu	37	chr19	5661692	5661692	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggagcgcgaacgcatgcacGtggagcacgagcgcaggcgc	17	12	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:5661692G>A	ENST00000292123.5	+	15	2133	c.2026G>A	c.(2026-2028)Gtg>Atg	p.V676M	SAFB_ENST00000538656.1_Missense_Mutation_p.V518M|SAFB_ENST00000454510.1_Missense_Mutation_p.V607M|SAFB_ENST00000433404.1_Missense_Mutation_p.V506M|SAFB_ENST00000592224.1_Missense_Mutation_p.V675M|SAFB_ENST00000588852.1_Missense_Mutation_p.V676M	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	676	Arg-rich.|Glu-rich.|Interaction with POLR2A.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		ACGCATGCACGTGGAGCACGA	0.711													12	19					0	0	1	0	0	A	5661692	G	A	5661692	3	1	21	1	0	0	0	0	1	0	0	0	13857	1145	40	1	2084	1	SAFB	19	5661692	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	530600	5661692	53467291	702	2123										
KHSRP	8570	broad.mit.edu	37	chr19	6417016	6417016	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accctgaggctctggaggagGtcgttgatgatccgggctgc	16	10	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:6417016G>A	ENST00000398148.3	-	12	1256	c.1164C>T	c.(1162-1164)gaC>gaT	p.D388D		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	388	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						TCTGGAGGAGGTCGTTGATGA	0.642													9	103					0	0	1	0	0	A	6417016	G	A	6417016	2	1	21	1	0	0	0	0	0	0	0	1	8192	1252	44	3		3	KHSRP	19	6417016	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	755324	6417016	52711967	703	2124										
PNPLA6	10908	broad.mit.edu	37	chr19	7623913	7623913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catggctgaaatccagtcccGcctggcctacgtgtcctgtg	11	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:7623913G>A	ENST00000221249.6	+	31	3892	c.3461G>A	c.(3460-3462)cGc>cAc	p.R1154H	PNPLA6_ENST00000600737.1_Missense_Mutation_p.R1192H|PNPLA6_ENST00000545201.2_Missense_Mutation_p.R1127H|PNPLA6_ENST00000414982.3_Missense_Mutation_p.R1202H|PNPLA6_ENST00000450331.3_Missense_Mutation_p.R1154H	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	1193					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						ATCCAGTCCCGCCTGGCCTAC	0.607													31	40					0	0	1	0	0	A	7623913	G	A	7623913	3	1	21	1	0	0	0	0	1	0	0	0	12216	1087	38	1	3719	1	PNPLA6	19	7623913	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1206897	7623913	51505070	704	2125										
MUC16	94025	broad.mit.edu	37	chr19	9062393	9062394	+	Frame_Shift_Del	DEL	TG	TG	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtcctcacgttggtcactgcTgtgtgtgtggaaggctgcat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:9062393_9062394delTG	ENST00000397910.4	-	3	25255_25256	c.25052_25053delCA	c.(25051-25053)afs	p.T8351fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8353	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTCACTGCTGTGTGTGTGGA	0.485													57	88	---	---	---	---						-	9062394	TG	-	9062393	7	5	21	1	0	1	0	1	0	0	0	0	10020	1567	55	0	18798	0	MUC16	19	9062393	Frame_Shift_Del	DEL	TG	TCGA-N7-A4Y0-01A-12D-A28R-08	1438480	9062393	50066590	705	2126										
OLFM2	93145	broad.mit.edu	37	chr19	9964925	9964925	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttgtagagcacctggtggccGttgttccaggtatagagggc	15	8	0	2	rs139281596	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:9964925G>A	ENST00000264833.4	-	6	1487	c.1302C>T	c.(1300-1302)aaC>aaT	p.N434N	OLFM2_ENST00000590841.1_Silent_p.N356N	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	434	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CCTGGTGGCCGTTGTTCCAGG	0.602													52	61					0	0	1	0	0	A	9964925	G	A	9964925	2	1	21	1	0	0	0	0	0	0	0	1	10900	1136	40	1		1	OLFM2	19	9964925	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	902532	9964925	49164058	706	2127										
COL5A3	50509	broad.mit.edu	37	chr19	10078753	10078753	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagccaatgggaccagggggAccctaggaaaaggacatcgg	16	9	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:10078753A>G	ENST00000264828.3	-	60	4402	c.4317T>C	c.(4315-4317)ggT>ggC	p.G1439G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1439	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GACCAGGGGGACCCTAGGAAA	0.582													37	52					0	0	1	0	0	G	10078753	A	G	10078753	2	3	21	1	0	0	0	0	0	0	0	1	3721	262	10	4		4	COL5A3	19	10078753	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	113828	10078753	49050230	707	2128										
S1PR2	9294	broad.mit.edu	37	chr19	10335188	10335188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttgaccttggcaatggccaCgtggcgctcaatggcgatgg	14	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:10335188C>T	ENST00000590320.1	-	2	504	c.394G>A	c.(394-396)Gtg>Atg	p.V132M		NM_004230.3	NP_004221.3	O95136	S1PR2_HUMAN	sphingosine-1-phosphate receptor 2	132					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCAATGGCCACGTGGCGCTCA	0.637													29	43					0	0	1	0	0	T	10335188	C	T	10335188	3	4	21	1	0	0	0	0	1	0	0	0	13845	536	19	1	671	1	S1PR2	19	10335188	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	256435	10335188	48793795	708	2129										
TSPAN16	26526	broad.mit.edu	37	chr19	11409591	11409591	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcatcatggaagttacagCtgccacagtggtccttcttt	8	12	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:11409591C>T	ENST00000316737.1	+	3	461	c.311C>T	c.(310-312)gCt>gTt	p.A104V	TSPAN16_ENST00000590327.1_Missense_Mutation_p.A104V|TSPAN16_ENST00000592955.1_Intron	NM_012466.2	NP_036598.1	Q9UKR8	TSN16_HUMAN	tetraspanin 16	104						integral to membrane				breast(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|stomach(1)	12						GAAGTTACAGCTGCCACAGTG	0.512													30	69					0	0	1	0	0	T	11409591	C	T	11409591	3	4	21	1	0	0	0	0	1	0	0	0	16700	797	28	3	321	3	TSPAN16	19	11409591	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1074403	11409591	47719392	709	2130										
ZNF433	163059	broad.mit.edu	37	chr19	12127235	12127235	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaggagagacagttgaaaggTtttttacagtatttacattt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:12127235delT	ENST00000419886.2	-	5	633	c.342delA	c.(340-342)aafs	p.K114fs	CTD-2006C1.2_ENST00000406892.2_RNA|ZNF433_ENST00000344980.6_Frame_Shift_Del_p.K149fs|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000495324.1_RNA			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						AGTTGAAAGGTTTTTTACAGT	0.368													61	89	---	---	---	---						-	12127235	T	-	12127235	7	5	21	1	0	1	0	1	0	0	0	0	17963	1722	60	0	1578	0	ZNF433	19	12127235	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	717644	12127235	47001748	710	2131										
TNPO2	30000	broad.mit.edu	37	chr19	12825886	12825886	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgatgctgtgcatgtgggggAtgagcctgtcaatccgcact	14	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:12825886A>G	ENST00000425528.1	-	9	1103	c.746T>C	c.(745-747)aTc>aCc	p.I249T	TNPO2_ENST00000592287.1_Missense_Mutation_p.I249T|TNPO2_ENST00000441499.1_Missense_Mutation_p.I249T|TNPO2_ENST00000588216.1_Missense_Mutation_p.I249T|TNPO2_ENST00000356861.5_Missense_Mutation_p.I249T|TNPO2_ENST00000450764.2_Missense_Mutation_p.I249T|TNPO2_ENST00000589956.1_Intron			O14787	TNPO2_HUMAN	transportin 2	249					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CATGTGGGGGATGAGCCTGTC	0.642													37	43					0	0	1	0	0	G	12825886	A	G	12825886	3	3	21	1	0	0	0	0	1	0	0	0	16395	333	12	4	2015	4	TNPO2	19	12825886	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	698651	12825886	46303097	711	2132										
MRI1	84245	broad.mit.edu	37	chr19	13879657	13879657	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgtggtcgtgggagctgaCcgcgtggttgccaacggcga	18	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:13879657C>T	ENST00000319545.8	+	5	660	c.603C>T	c.(601-603)gaC>gaT	p.D201D	MRI1_ENST00000040663.6_Silent_p.D248D	NM_032285.2	NP_115661.1	Q9BV20	MTNA_HUMAN	methylthioribose-1-phosphate isomerase 1	248					L-methionine salvage from methylthioadenosine	cell projection|cytoplasm|nucleus	identical protein binding|S-methyl-5-thioribose-1-phosphate isomerase activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6						TGGGAGCTGACCGCGTGGTTG	0.647													10	29					0	0	1	0	0	T	13879657	C	T	13879657	2	4	21	1	0	0	0	0	0	0	0	1	9818	506	18	3		3	MRI1	19	13879657	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1053771	13879657	45249326	712	2133										
NOTCH3	4854	broad.mit.edu	37	chr19	15295220	15295220	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accatgagggccacagggtgCggggccagcacactcgtcca	14	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:15295220C>T	ENST00000263388.2	-	16	2527	c.2452G>A	c.(2452-2454)Gca>Aca	p.A818T		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	818	EGF-like 21; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.A818S(2)		breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCACAGGGTGCGGGGCCAGCA	0.612													23	50					0	0	1	0	0	T	15295220	C	T	15295220	3	4	21	1	0	0	0	0	1	0	0	0	10596	768	27	1	4585	1	NOTCH3	19	15295220	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1415563	15295220	43833763	713	2134										
RASAL3	64926	broad.mit.edu	37	chr19	15572069	15572069	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	atggccacgtggatgctgccCtcggagctagcacttcccac	11	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:15572069C>A	ENST00000343625.6	-	4	584	c.504G>T	c.(502-504)gaG>gaT	p.E168D		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	168					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						GGATGCTGCCCTCGGAGCTAG	0.627													13	21					9.31168e-06	9.57367e-06	1	1	0	A	15572069	C	A	15572069	3	1	21	1	0	0	0	0	1	0	0	0	13116	680	24	5	2591	5	RASAL3	19	15572069	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	276849	15572069	43556914	714	2135										
EPS15L1	58513	broad.mit.edu	37	chr19	16528892	16528892	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtctttgcttaacttccccGtttgcctcgtatcggccagg	10	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:16528892G>A	ENST00000602009.1	-	5	1407	c.512C>T	c.(511-513)aCg>aTg	p.T171M	EPS15L1_ENST00000535753.2_Missense_Mutation_p.T325M|EPS15L1_ENST00000594975.1_Missense_Mutation_p.T325M|EPS15L1_ENST00000248070.6_Missense_Mutation_p.T325M|EPS15L1_ENST00000455140.2_Missense_Mutation_p.T325M|EPS15L1_ENST00000597937.1_Missense_Mutation_p.T325M			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	325	EF-hand.|EH 2.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						TAACTTCCCCGTTTGCCTCGT	0.537											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	43					0	0	1	0	0	A	16528892	G	A	16528892	3	1	21	1	0	0	0	0	1	0	0	0	5221	1145	40	1	1672	1	EPS15L1	19	16528892	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	956823	16528892	42600091	715	2136										
CPAMD8	27151	broad.mit.edu	37	chr19	17108016	17108016	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgcacgggggtggagtcatCgaacgcgacctgctggctcc	15	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17108016C>T	ENST00000443236.1	-	11	1172	c.1141G>A	c.(1141-1143)Gat>Aat	p.D381N	CPAMD8_ENST00000388925.4_Missense_Mutation_p.D334N	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	334						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GTGGAGTCATCGAACGCGACC	0.642													17	25					0	0	1	0	0	T	17108016	C	T	17108016	3	4	21	1	0	0	0	0	1	0	0	0	3818	884	31	1	4785	1	CPAMD8	19	17108016	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	579124	17108016	42020967	716	2137										
MAP1S	55201	broad.mit.edu	37	chr19	17836817	17836817	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccaactctgagggcctgtgCgaattcctggagtacgtggc	13	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17836817C>T	ENST00000324096.4	+	5	775	c.624C>T	c.(622-624)tgC>tgT	p.C208C	MAP1S_ENST00000597681.1_Intron|MAP1S_ENST00000544059.2_Silent_p.C182C	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	208	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						AGGGCCTGTGCGAATTCCTGG	0.716													13	15					0	0	1	0	0	T	17836817	C	T	17836817	2	4	21	1	0	0	0	0	0	0	0	1	9283	776	27	1		1	MAP1S	19	17836817	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	728801	17836817	41292166	717	2138										
JAK3	3718	broad.mit.edu	37	chr19	17955064	17955064	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctggccttggcagcctgcaCgcacaggtcctcagccaagt	12	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17955064C>T	ENST00000458235.1	-	2	262	c.163G>A	c.(163-165)Gtg>Atg	p.V55M	JAK3_ENST00000534444.1_Missense_Mutation_p.V55M|JAK3_ENST00000527670.1_Missense_Mutation_p.V55M|JAK3_ENST00000526008.1_5'UTR	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	55	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.V55L(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GCAGCCTGCACGCACAGGTCC	0.657		2	Mis		"acute megakaryocytic leukemia, ETP ALL"								8	11					0	0	1	0	0	T	17955064	C	T	17955064	3	4	21	1	0	0	0	0	1	0	0	0	7982	536	19	1	3303	1	JAK3	19	17955064	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	118247	17955064	41173919	718	2139										
KIAA1683	80726	broad.mit.edu	37	chr19	18378026	18378026	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctccagttggcttggatgagCgtggctgcacgggcgtgcat	16	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:18378026C>T	ENST00000392413.3	-	3	539	c.324G>A	c.(322-324)acG>acA	p.T108T	KIAA1683_ENST00000600328.2_Silent_p.T108T|KIAA1683_ENST00000600359.2_Silent_p.T62T	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	108	IQ 1.					mitochondrion		p.T108T(1)		breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTTGGATGAGCGTGGCTGCAC	0.637													56	70					0	0	1	0	0	T	18378026	C	T	18378026	2	4	21	1	0	0	0	0	0	0	0	1	8292	755	27	1		1	KIAA1683	19	18378026	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	422962	18378026	40750957	719	2140										
ELL	8178	broad.mit.edu	37	chr19	18569071	18569073	+	In_Frame_Del	DEL	CTT	CTT	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccgagtagccaggccagtcCttctgcacatccttgtacat							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:18569071_18569073delCTT	ENST00000262809.4	-	6	882_884	c.811_813delAAG	c.(811-813)del	p.K271del		NM_006532.3	NP_006523.1	P55199	ELL_HUMAN	elongation factor RNA polymerase II	271					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		CAGGCCAGTCCTTCTGCACATCC	0.601			T	MLL	AL								30	50	---	---	---	---						-	18569073	CTT	-	18569071	7	5	21	1	0	1	0	1	0	0	0	0	5090	680	24	0	1080	0	ELL	19	18569071	In_Frame_Del	DEL	CTT	TCGA-N7-A4Y0-01A-12D-A28R-08	191045	18569071	40559912	720	2141										
SLC25A42	284439	broad.mit.edu	37	chr19	19218753	19218753	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catctcgagagaagaggggcTgaagactctctaccatggat	12	9	2	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:19218753T>C	ENST00000318596.7	+	7	699	c.548T>C	c.(547-549)cTg>cCg	p.L183P	SLC25A42_ENST00000600275.1_3'UTR	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	183					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			GAAGAGGGGCTGAAGACTCTC	0.562													118	88					0	0	1	0	0	C	19218753	T	C	19218753	3	2	21	1	0	0	0	0	1	0	0	0	14561	1580	55	4	570	4	SLC25A42	19	19218753	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	649682	19218753	39910230	721	2142										
ANKRD27	84079	broad.mit.edu	37	chr19	33095253	33095253	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcagaagcagctctaccacGaagacgtgcttttcaatcac	8	12	3	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:33095253G>A	ENST00000306065.4	-	25	2729	c.2571C>T	c.(2569-2571)ttC>ttT	p.F857F		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	857					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity	p.F857F(1)		breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					GCTCTACCACGAAGACGTGCT	0.557													23	25					0	0	1	0	0	A	33095253	G	A	33095253	2	1	21	1	0	0	0	0	0	0	0	1	651	1049	37	1		1	ANKRD27	19	33095253	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	13876500	33095253	26033730	722	2143										
GRAMD1A	57655	broad.mit.edu	37	chr19	35500223	35500223	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggcagccggaacttcatccGcaacagcaaggttggtgcaa	12	11	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:35500223G>A	ENST00000599564.1	+	3	541	c.470G>A	c.(469-471)cGc>cAc	p.R157H	GRAMD1A_ENST00000598073.1_3'UTR|GRAMD1A_ENST00000317991.5_Missense_Mutation_p.R70H|GRAMD1A_ENST00000411896.2_Missense_Mutation_p.R70H|GRAMD1A_ENST00000504615.2_5'UTR|GRAMD1A_ENST00000424536.2_Missense_Mutation_p.R70H			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	70	GRAM.					integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AACTTCATCCGCAACAGCAAG	0.622													36	56					0	0	1	0	0	A	35500223	G	A	35500223	3	1	21	1	0	0	0	0	1	0	0	0	6787	1087	38	1	215	1	GRAMD1A	19	35500223	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2404970	35500223	23628760	723	2144										
APLP1	333	broad.mit.edu	37	chr19	36365461	36365461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtgtctggtgagcgacagcGcctggtggaaacccacgcca	15	12	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:36365461G>A	ENST00000221891.4	+	9	1304	c.1112G>A	c.(1111-1113)cGc>cAc	p.R371H	APLP1_ENST00000586861.1_Missense_Mutation_p.R365H|APLP1_ENST00000589298.2_3'UTR|APLP1_ENST00000537454.2_Missense_Mutation_p.R332H	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	371					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCGACAGCGCCTGGTGGAA	0.652													75	86					0	0	1	0	0	A	36365461	G	A	36365461	3	1	21	1	0	0	0	0	1	0	0	0	775	1087	38	1	1146	1	APLP1	19	36365461	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	865238	36365461	22763522	724	2145										
WDR62	284403	broad.mit.edu	37	chr19	36574054	36574054	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgggggagcgagaatgggacAcccatggacgtgaaagccgg	18	9	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:36574054A>G	ENST00000401500.2	+	11	1496	c.1461A>G	c.(1459-1461)acA>acG	p.T487T	WDR62_ENST00000270301.7_Silent_p.T487T	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	487					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGAATGGGACACCCATGGACG	0.602													4	14					0	0	1	0	0	G	36574054	A	G	36574054	2	3	21	1	0	0	0	0	0	0	0	1	17372	146	6	4		4	WDR62	19	36574054	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	208593	36574054	22554929	725	2146										
ZNF260	339324	broad.mit.edu	37	chr19	37005246	37005246	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttcatagggtttctctcctgTatgaatattgtgatgtttaa	8	5	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:37005246T>C	ENST00000523638.1	-	3	2016	c.895A>G	c.(895-897)Aca>Gca	p.T299A	ZNF260_ENST00000588993.1_Missense_Mutation_p.T299A|ZNF260_ENST00000592282.1_Missense_Mutation_p.T299A|ZNF260_ENST00000593142.1_Missense_Mutation_p.T299A	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	299					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TTCTCTCCTGTATGAATATTG	0.353													53	50					0	0	1	0	0	C	37005246	T	C	37005246	3	2	21	1	0	0	0	0	1	0	0	0	17859	1638	57	4	347	4	ZNF260	19	37005246	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	431192	37005246	22123737	726	2147										
ZNF571	51276	broad.mit.edu	37	chr19	38056224	38056224	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agccacgaaaaaaggtcttcCcgcattctttacattcatag	6	11	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:38056224C>A	ENST00000328550.2	-	4	1205	c.1106G>T	c.(1105-1107)gGg>gTg	p.G369V	ZNF571-AS1_ENST00000586013.1_RNA|ZNF571_ENST00000358744.3_Missense_Mutation_p.G369V|ZNF571-AS1_ENST00000592392.1_RNA|ZNF571-AS1_ENST00000585578.1_RNA|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571_ENST00000593133.1_Missense_Mutation_p.G369V|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA|ZNF571_ENST00000590751.1_Intron|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571_ENST00000451802.2_Missense_Mutation_p.G369V|ZNF571-AS1_ENST00000589802.1_RNA			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAGGTCTTCCCGCATTCTTT	0.393													15	30					2.31682e-05	2.37644e-05	1	1	0	A	38056224	C	A	38056224	3	1	21	1	0	0	0	0	1	0	0	0	18059	623	22	5	727	5	ZNF571	19	38056224	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1050978	38056224	21072759	727	2148										
PAK4	0	broad.mit.edu	37	chr19	39664268	39664269	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcagcggggggcctggccatINScccccagtcctcctcctcct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:39664268_39664269insC	ENST00000599386.1	+	4	438_439	c.257_258insC	c.(256-258)accfs	p.T86fs	PAK4_ENST00000321944.4_Frame_Shift_Ins_p.T149fs|PAK4_ENST00000358301.3_Frame_Shift_Ins_p.T239fs|PAK4_ENST00000599470.1_Frame_Shift_Ins_p.T86fs|PAK4_ENST00000593690.1_Frame_Shift_Ins_p.T239fs|PAK4_ENST00000360442.3_Frame_Shift_Ins_p.T239fs|PAK4_ENST00000435673.2_Frame_Shift_Ins_p.T239fs	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	239	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			GGCCTGGCCATCCCCCAGTCCT	0.703													19	17	---	---	---	---						C	39664269	-	C	39664268	7	5	21	1	0	1	1	0	0	0	0	0	11449	1435	50	0	726	0	PAK4	19	39664268	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	1608044	39664268	19464715	728	2149										
SUPT5H	6829	broad.mit.edu	37	chr19	39963560	39963560	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgtgcgcatctcccaggggCcctacaaaggtgacctgcga	12	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:39963560C>T	ENST00000599117.1	+	23	2513	c.2146C>T	c.(2146-2148)Ccc>Tcc	p.P716S	SUPT5H_ENST00000402194.2_Missense_Mutation_p.P712S|SUPT5H_ENST00000432763.2_Missense_Mutation_p.P716S|SUPT5H_ENST00000598725.1_Missense_Mutation_p.P716S|SUPT5H_ENST00000359191.6_Missense_Mutation_p.P712S			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	716	KOW 5.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTCCCAGGGGCCCTACAAAGG	0.682													23	41					0	0	1	0	0	T	39963560	C	T	39963560	3	4	21	1	0	0	0	0	1	0	0	0	15454	739	26	3	2228	3	SUPT5H	19	39963560	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	299292	39963560	19165423	729	2150										
DYRK1B	9149	broad.mit.edu	37	chr19	40316673	40316673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaggcaggggcttgatgtgtCttgtggggcacatcaccccc	15	11	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:40316673C>T	ENST00000593685.1	-	11	2040	c.1572G>A	c.(1570-1572)aaG>aaA	p.K524K	DYRK1B_ENST00000430012.2_Silent_p.K484K|DYRK1B_ENST00000597639.1_Silent_p.K496K|DYRK1B_ENST00000348817.3_Silent_p.K496K|DYRK1B_ENST00000323039.5_Silent_p.K524K			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	524					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CTTGATGTGTCTTGTGGGGCA	0.642													29	51					0	0	1	0	0	T	40316673	C	T	40316673	2	4	21	1	0	0	0	0	0	0	0	1	4881	912	32	3		3	DYRK1B	19	40316673	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	353113	40316673	18812310	730	2151										
FBL	2091	broad.mit.edu	37	chr19	40331278	40331278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acctcttcctcctcctccacCgccgccgccgcctccacctc	4	26	1	0	rs139541583		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:40331278C>T	ENST00000221801.3	-	2	273	c.160G>A	c.(160-162)Ggt>Agt	p.G54S		NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	54	DMA/Gly-rich.				rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		cctcctccaccgccgccgccg	0.662													17	17					0	0	1	0	0	T	40331278	C	T	40331278	3	4	21	1	0	0	0	0	1	0	0	0	5728	652	23	1	837	1	FBL	19	40331278	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	14605	40331278	18797705	731	2152										
SPTBN4	57731	broad.mit.edu	37	chr19	41000844	41000844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agaatttcaccaccagctggCgggatggcttggccttcaat	11	11	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:41000844C>T	ENST00000352632.3	+	6	714	c.628C>T	c.(628-630)Cgg>Tgg	p.R210W	SPTBN4_ENST00000595535.1_Missense_Mutation_p.R210W|SPTBN4_ENST00000598249.1_Missense_Mutation_p.R210W|SPTBN4_ENST00000344104.3_Missense_Mutation_p.R210W|SPTBN4_ENST00000338932.3_Missense_Mutation_p.R210W			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	210	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CACCAGCTGGCGGGATGGCTT	0.582													20	36					0	0	1	0	0	T	41000844	C	T	41000844	3	4	21	1	0	0	0	0	1	0	0	0	15176	759	27	1	646	1	SPTBN4	19	41000844	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	669566	41000844	18128139	732	2153										
DMRTC2	63946	broad.mit.edu	37	chr19	42351810	42351810	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctccccacttttagggagcgCcgcagggtcatggctgccca	12	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:42351810C>T	ENST00000269945.3	+	3	282	c.231C>T	c.(229-231)cgC>cgT	p.R77R	DMRTC2_ENST00000602098.1_3'UTR|DMRTC2_ENST00000596827.1_Silent_p.R77R	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	77					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						TTAGGGAGCGCCGCAGGGTCA	0.602													13	26					0	0	1	0	0	T	42351810	C	T	42351810	2	4	21	1	0	0	0	0	0	0	0	1	4619	726	26	3		3	DMRTC2	19	42351810	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1350966	42351810	16777173	733	2154										
XRCC1	7515	broad.mit.edu	37	chr19	44057626	44057626	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttggcgctctcatcctcctcCttcacacggaactggccaag	8	16	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:44057626C>A	ENST00000262887.5	-	6	1075	c.528G>T	c.(526-528)aaG>aaT	p.K176N	XRCC1_ENST00000543982.1_Missense_Mutation_p.K145N|L34079.3_ENST00000597119.1_RNA			P18887	XRCC1_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 1	176					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Prostate(69;0.0153)				CATCCTCCTCCTTCACACGGA	0.597								Other BER factors					42	55					3.54561e-26	3.96114e-26	1	1	0	A	44057626	C	A	44057626	3	1	21	1	0	0	0	0	1	0	0	0	17511	680	24	5	1421	5	XRCC1	19	44057626	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1705816	44057626	15071357	734	2155										
BCL3	602	broad.mit.edu	37	chr19	45260667	45260667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcgcggtgccgacatcgacGcagtggtgagcgtgcactag	16	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:45260667G>A	ENST00000164227.5	+	5	1052	c.808G>A	c.(808-810)Gca>Aca	p.A270T		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	270					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CGACATCGACGCAGTGGTGAG	0.692			T	IGH@	CLL								3	8					0	0	1	0	0	A	45260667	G	A	45260667	3	1	21	1	0	0	0	0	1	0	0	0	1373	1087	38	1	826	1	BCL3	19	45260667	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1203041	45260667	13868316	735	2156										
NKPD1	284353	broad.mit.edu	37	chr19	45655971	45655971	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccccgcctgcgcctgcaccGccagcagctgcgcgctctcg	11	21	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:45655971G>A	ENST00000317951.4	-	4	1723	c.1724C>T	c.(1723-1725)gCg>gTg	p.A575V	NKPD1_ENST00000589776.1_Missense_Mutation_p.A353V|NKPD1_ENST00000429338.1_Missense_Mutation_p.A353V|NKPD1_ENST00000438936.2_Missense_Mutation_p.A353V	NM_198478.3	NP_940880.3			NTPase, KAP family P-loop domain containing 1											endometrium(1)|lung(4)|prostate(2)|urinary_tract(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CGCCTGCACCGCCAGCAGCTG	0.741													5	8					0	0	1	0	0	A	45655971	G	A	45655971	3	1	21	1	0	0	0	0	1	0	0	0	10492	1087	38	1	778	1	NKPD1	19	45655971	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	395304	45655971	13473012	736	2157										
DMPK	1760	broad.mit.edu	37	chr19	46283185	46283185	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agaaagggcactggagacaaGggggaaagccccaccctctg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:46283185delG	ENST00000600757.1	-	1	820	c.133delC	c.(133-135)ttfs	p.L45fs	DMPK_ENST00000291270.4_Intron|DMPK_ENST00000458663.2_Intron|DMPK_ENST00000447742.2_Intron|DMPK_ENST00000354227.5_Intron|AC011530.4_ENST00000593999.1_Intron|DMPK_ENST00000343373.4_Frame_Shift_Del_p.L45fs			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	45					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CTGGAGACAAGGGGGAAAGCC	0.612													14	24	---	---	---	---						-	46283185	G	-	46283185	7	5	21	1	0	1	0	1	0	0	0	0	4612	1000	35	0	1849	0	DMPK	19	46283185	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	627214	46283185	12845798	737	2158										
HIF3A	64344	broad.mit.edu	37	chr19	46815488	46815488	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctacgagtacatccacgcgCtggactccgatgcggtcagc	11	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:46815488C>T	ENST00000339613.2	+	7	928	c.673C>T	c.(673-675)Ctg>Ttg	p.L225L	HIF3A_ENST00000300862.3_Silent_p.L279L|HIF3A_ENST00000244303.6_Silent_p.L212L|HIF3A_ENST00000525854.1_3'UTR|HIF3A_ENST00000420102.2_Silent_p.L230L|HIF3A_ENST00000600383.1_Silent_p.L212L|HIF3A_ENST00000472815.1_Silent_p.L212L|HIF3A_ENST00000377670.4_Silent_p.L281L			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CATCCACGCGCTGGACTCCGA	0.612													58	86					0	0	1	0	0	T	46815488	C	T	46815488	2	4	21	1	0	0	0	0	0	0	0	1	7145	796	28	3		3	HIF3A	19	46815488	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	532303	46815488	12313495	738	2159										
FKRP	79147	broad.mit.edu	37	chr19	47260141	47260141	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagttcgggcccggggtcatCgagaacccccagtaccccaa	11	15	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:47260141C>T	ENST00000318584.5	+	4	1731	c.1434C>T	c.(1432-1434)atC>atT	p.I478I	FKRP_ENST00000391909.3_Silent_p.I478I|FKRP_ENST00000600646.1_Intron	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	478						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		CCGGGGTCATCGAGAACCCCC	0.637													9	11					0	0	1	0	0	T	47260141	C	T	47260141	2	4	21	1	0	0	0	0	0	0	0	1	5949	874	31	1		1	FKRP	19	47260141	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	444653	47260141	11868842	739	2160										
ARHGAP35	2909	broad.mit.edu	37	chr19	47424741	47424741	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacttgagatctttcacccaTtttttaaagatgtggtggaa							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:47424741delT	ENST00000404338.3	+	1	2809	c.2809delT	c.(2809-2811)ttfs	p.F938fs		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	938					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTTTCACCCATTTTTTAAAGA	0.453													77	118	---	---	---	---						-	47424741	T	-	47424741	7	5	21	1	0	1	0	1	0	0	0	0	6835	1493	52	0	2811	0	ARHGAP35	19	47424741	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	164600	47424741	11704242	740	2161										
DHX34	9704	broad.mit.edu	37	chr19	47856557	47856557	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggacagcccaagcacagcatCccagcgctggccgacctacc	10	18	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:47856557C>A	ENST00000328771.4	+	2	619	c.270C>A	c.(268-270)atC>atA	p.I90I		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	90						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGCACAGCATCCCAGCGCTGG	0.587													54	105					6.176e-18	6.71171e-18	1	1	0	A	47856557	C	A	47856557	2	1	21	1	0	0	0	0	0	0	0	1	4535	845	30	2		2	DHX34	19	47856557	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	431816	47856557	11272426	741	2162										
TMEM143	55260	broad.mit.edu	37	chr19	48848477	48848477	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccagggtgtcctcagacagCggggagaagttggcctgggc	18	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:48848477C>T	ENST00000293261.3	-	4	820	c.504G>A	c.(502-504)ccG>ccA	p.P168P	TMEM143_ENST00000377431.2_Intron|TMEM143_ENST00000435956.3_Silent_p.P133P|TMEM143_ENST00000436660.2_Intron|TMEM143_ENST00000541566.1_Silent_p.P58P	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	168						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		CCTCAGACAGCGGGGAGAAGT	0.622													67	96					0	0	1	0	0	T	48848477	C	T	48848477	2	4	21	1	0	0	0	0	0	0	0	1	16116	755	27	1		1	TMEM143	19	48848477	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	991920	48848477	10280506	742	2163										
RASIP1	54922	broad.mit.edu	37	chr19	49232773	49232773	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccacatagggagccggggaCcccccgcggccagacgagtt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49232773delC	ENST00000222145.4	-	5	1458	c.1254delG	c.(1252-1254)ggfs	p.G418fs		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	418					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GAGCCGGGGACCCCCCGCGGC	0.657													9	6	---	---	---	---						-	49232773	C	-	49232773	7	5	21	1	0	1	0	1	0	0	0	0	13129	494	18	0	1669	0	RASIP1	19	49232773	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	384296	49232773	9896210	743	2164										
CD37	0	broad.mit.edu	37	chr19	49841230	49841230	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agaaaaccatccaaaagtacGgcaccaaccccgaggagacc	8	14	0	2	rs147415665		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49841230G>A	ENST00000535669.2	+	5	505	c.391G>A	c.(391-393)Ggc>Agc	p.G131S	CTC-301O7.4_ENST00000358234.4_lincRNA|CD37_ENST00000598095.1_Missense_Mutation_p.G63S|CD37_ENST00000323906.4_Missense_Mutation_p.G131S|CD37_ENST00000426897.2_Missense_Mutation_p.G63S|CD37_ENST00000596426.1_3'UTR			P11049	CD37_HUMAN	CD37 molecule	131						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	11		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		CCAAAAGTACGGCACCAACCC	0.642													22	33					0	0	1	0	0	A	49841230	G	A	49841230	3	1	21	1	0	0	0	0	1	0	0	0	3030	1116	39	1	409	1	CD37	19	49841230	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	608457	49841230	9287753	744	2165										
TEAD2	8463	broad.mit.edu	37	chr19	49845739	49845739	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gacgctgttcatcatgtatcGctcaggcagctgccgcaact	10	13	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49845739G>A	ENST00000377214.4	-	10	1557	c.1195C>T	c.(1195-1197)Cga>Tga	p.R399*	TEAD2_ENST00000598810.1_Nonsense_Mutation_p.R400*|TEAD2_ENST00000539846.1_Nonsense_Mutation_p.R268*|TEAD2_ENST00000593945.1_Nonsense_Mutation_p.R400*|TEAD2_ENST00000601519.1_Nonsense_Mutation_p.R399*|TEAD2_ENST00000311227.2_Nonsense_Mutation_p.R396*			Q15562	TEAD2_HUMAN	TEA domain family member 2	396	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	29		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		ATCATGTATCGCTCAGGCAGC	0.602													41	54					0	0	1	0	0	A	49845739	G	A	49845739	4	1	21	1	0	0	0	0	0	1	0	0	15797	1095	38	1	165	1	TEAD2	19	49845739	Nonsense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4509	49845739	9283244	745	2166										
FLT3LG	0	broad.mit.edu	37	chr19	49982287	49982287	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaacttctcccggtgcctggAgctgcagtgtcagcccggta	13	13	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49982287A>T	ENST00000595510.1	+	5	519	c.218A>T	c.(217-219)gAg>gTg	p.E73V	CTD-3148I10.9_ENST00000599536.1_Intron|FLT3LG_ENST00000204637.2_Missense_Mutation_p.E73V|FLT3LG_ENST00000600429.1_Missense_Mutation_p.E155V|FLT3LG_ENST00000344019.3_Missense_Mutation_p.E155V|FLT3LG_ENST00000595815.1_3'UTR|FLT3LG_ENST00000596435.1_Missense_Mutation_p.E137V|FLT3LG_ENST00000597551.1_Missense_Mutation_p.E155V|FLT3LG_ENST00000594009.1_Missense_Mutation_p.E155V			P49771	FLT3L_HUMAN	fms-related tyrosine kinase 3 ligand	155					positive regulation of cell proliferation|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity			large_intestine(2)|lung(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	10		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		CGGTGCCTGGAGCTGCAGTGT	0.647													8	11					0	0	1	0	0	T	49982287	A	T	49982287	3	4	21	1	0	0	0	0	1	0	0	0	5975	304	11	4	482	4	FLT3LG	19	49982287	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	136548	49982287	9146696	746	2167										
TBC1D17	79735	broad.mit.edu	37	chr19	50381767	50381767	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	taccctaggacaatgacgtcCtcctgcactgggctcctgta	9	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:50381767C>A	ENST00000221543.5	+	3	432	c.133C>A	c.(133-135)Ctc>Atc	p.L45I	TBC1D17_ENST00000598789.1_3'UTR|TBC1D17_ENST00000535102.2_Missense_Mutation_p.L12I	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	45						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CAATGACGTCCTCCTGCACTG	0.537													36	36					6.1244e-12	6.52625e-12	1	1	0	A	50381767	C	A	50381767	3	1	21	1	0	0	0	0	1	0	0	0	15662	681	24	5	143	5	TBC1D17	19	50381767	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	399480	50381767	8747216	747	2168										
IL4I1	259307	broad.mit.edu	37	chr19	50393104	50393104	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggccgtgtccgatgcaggCcccttccggctgttgatctt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:50393104delC	ENST00000595948.1	-	10	2213	c.1593delG	c.(1591-1593)ggfs	p.G531fs	IL4I1_ENST00000391826.2_Frame_Shift_Del_p.G509fs|IL4I1_ENST00000341114.3_Frame_Shift_Del_p.G531fs	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	509						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CCGATGCAGGCCCCTTCCGGC	0.687													31	33	---	---	---	---						-	50393104	C	-	50393104	7	5	21	1	0	1	0	1	0	0	0	0	7740	726	26	0	180	0	IL4I1	19	50393104	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	11337	50393104	8735879	748	2169										
FAM71E1	112703	broad.mit.edu	37	chr19	50979571	50979571	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctttatgacgtcacacaaGagcgggctcctgatttgtga	12	9	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:50979571G>T	ENST00000600100.1	-	1	439	c.75C>A	c.(73-75)ctC>ctA	p.L25L	FAM71E1_ENST00000595790.1_Silent_p.L25L			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	25										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		CGTCACACAAGAGCGGGCTCC	0.662													17	28					3.52763e-06	3.63969e-06	1	1	0	T	50979571	G	T	50979571	2	4	21	1	0	0	0	0	0	0	0	1	5645	929	33	2		2	FAM71E1	19	50979571	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	586467	50979571	8149412	749	2170										
SHANK1	50944	broad.mit.edu	37	chr19	51192558	51192559	+	Frame_Shift_Ins	INS	-	-	G													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggcagggaggcaggagaaatINSgggggggtggtggggggagt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:51192558_51192559insG	ENST00000391813.1	-	1	102_103	c.103_104insC	c.(103-105)tttfs	p.F35fs	SHANK1_ENST00000293441.1_Intron|SHANK1_ENST00000391814.1_Intron|SHANK1_ENST00000359082.3_Intron			Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1218					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCAGGAGAAATGGGGGGGTGGT	0.589													17	47	---	---	---	---						G	51192559	-	G	51192558	7	5	21	1	0	1	1	0	0	0	0	0	14318	1479	51	0		0	SHANK1	19	51192558	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	212987	51192558	7936425	750	2171										
SHANK1	50944	broad.mit.edu	37	chr19	51217078	51217078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagtgccaggcagtgtcgggCgcatgcggccttatgcagtg	17	10	0	0	rs138468869		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:51217078C>T	ENST00000293441.1	-	5	787	c.769G>A	c.(769-771)Gcc>Acc	p.A257T	SHANK1_ENST00000391814.1_Missense_Mutation_p.A257T|SHANK1_ENST00000359082.3_Missense_Mutation_p.A257T	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	257					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CAGTGTCGGGCGCATGCGGCC	0.627													42	56					0	0	1	0	0	T	51217078	C	T	51217078	3	4	21	1	0	0	0	0	1	0	0	0	14318	768	27	1	5792	1	SHANK1	19	51217078	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	24520	51217078	7911905	751	2172										
MBOAT7	79143	broad.mit.edu	37	chr19	54684567	54684567	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acggggtaggccccaaagccGgcggcaatgcagccgcactc	14	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:54684567G>A	ENST00000245615.1	-	6	1257	c.777C>T	c.(775-777)gcC>gcT	p.A259A	MBOAT7_ENST00000338624.6_Silent_p.A186A|MBOAT7_ENST00000391754.1_Silent_p.A259A|MBOAT7_ENST00000431666.2_Silent_p.A186A	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	259					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCCAAAGCCGGCGGCAATGC	0.711											OREG0003644	type=REGULATORY REGION|Gene=AK123290|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	8					0	0	1	0	0	A	54684567	G	A	54684567	2	1	21	1	0	0	0	0	0	0	0	1	9407	1103	39	1		1	MBOAT7	19	54684567	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3467489	54684567	4444416	752	2173										
NLRP2	55655	broad.mit.edu	37	chr19	55497518	55497518	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctttcgttctcttttccctaGgttcaaaaacatttccccag	4	13	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:55497518G>T	ENST00000543010.1	+	8	2344		c.e8-1		NLRP2_ENST00000537859.1_Splice_Site|NLRP2_ENST00000427260.2_Splice_Site|NLRP2_ENST00000339757.7_Splice_Site|NLRP2_ENST00000391721.4_Splice_Site|NLRP2_ENST00000538819.1_Splice_Site|NLRP2_ENST00000263437.6_Splice_Site|NLRP2_ENST00000448584.2_Splice_Site	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2						apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTTTTCCCTAGGTTCAAAAAC	0.423													15	27					1.05317e-09	1.1155e-09	1	1	0	T	55497518	G	T	55497518	5	4	21	1	0	0	0	0	0	0	1	0	10523	1014	35	5	2227	5	NLRP2	19	55497518	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	812951	55497518	3631465	753	2174										
NLRP9	338321	broad.mit.edu	37	chr19	56249561	56249561	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgctttcctgggtaatgtttGtccagcagctttgctacatc	9	10	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:56249561G>A	ENST00000332836.2	-	1	207	c.180C>T	c.(178-180)gaC>gaT	p.D60D		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	60	DAPIN.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGTAATGTTTGTCCAGCAGCT	0.468													248	323					0	0	1	0	0	A	56249561	G	A	56249561	2	1	21	1	0	0	0	0	0	0	0	1	10530	1368	48	3		3	NLRP9	19	56249561	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	752043	56249561	2879422	754	2175										
ZNF671	79891	broad.mit.edu	37	chr19	58232447	58232447	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actcgtatggcctttctccaGtgtgaactgtctggtgttta	10	9	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58232447G>A	ENST00000317398.6	-	4	1102	c.1007C>T	c.(1006-1008)aCt>aTt	p.T336I	ZNF671_ENST00000335820.3_Missense_Mutation_p.T238I|AC003006.7_ENST00000599221.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCTTTCTCCAGTGTGAACTGT	0.463													32	83					0	0	1	0	0	A	58232447	G	A	58232447	3	1	21	1	0	0	0	0	1	0	0	0	18134	1029	36	3	601	3	ZNF671	19	58232447	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1982886	58232447	896536	755	2176										
ZSCAN18	65982	broad.mit.edu	37	chr19	58596656	58596656	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gatcggcaagggcgtccccaGggggcgcctccgtaggcagc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58596656delG	ENST00000240727.6	-	7	1328	c.929delC	c.(928-930)ctfs	p.P310fs	ZSCAN18_ENST00000421612.2_Frame_Shift_Del_p.P174fs|ZSCAN18_ENST00000600404.1_Frame_Shift_Del_p.P366fs|ZSCAN18_ENST00000601144.1_Frame_Shift_Del_p.P310fs	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	310					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P310fs*119(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCGTCCCCAGGGGGCGCCTC	0.746													25	30	---	---	---	---						-	58596656	G	-	58596656	7	5	21	1	0	1	0	1	0	0	0	0	18270	1000	35	0	607	0	ZSCAN18	19	58596656	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	364209	58596656	532327	756	2177										
ZNF329	79673	broad.mit.edu	37	chr19	58640477	58640477	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccatgaataacttccatggAatggttgaagccttttccac	7	10	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58640477A>G	ENST00000598312.1	-	4	627	c.394T>C	c.(394-396)Tcc>Ccc	p.S132P	ZNF329_ENST00000358067.4_Missense_Mutation_p.S132P	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		ACTTCCATGGAATGGTTGAAG	0.423													62	55					0	0	1	0	0	G	58640477	A	G	58640477	3	3	21	1	0	0	0	0	1	0	0	0	17903	246	9	4	1235	4	ZNF329	19	58640477	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	43821	58640477	488506	757	2178										
ZSCAN22	342945	broad.mit.edu	37	chr19	58850389	58850389	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtgggaaagccttcagccaGagcacgcacctgactcaaca	10	13	2	2	rs140941763	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58850389G>A	ENST00000329665.4	+	3	1320	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	391					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCTTCAGCCAGAGCACGCACC	0.637													46	64					0	0	1	0	0	A	58850389	G	A	58850389	2	1	21	1	0	0	0	0	0	0	0	1	18274	933	33	3		3	ZSCAN22	19	58850389	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	209912	58850389	278594	758	2179										
TRIB3	57761	broad.mit.edu	37	chr20	368784	368784	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgggccccagcccagactgCccccctgcctgttgcccctg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:368784delC	ENST00000217233.3	+	2	683	c.130delC	c.(130-132)ccfs	p.P45fs	TRIB3_ENST00000422053.2_Frame_Shift_Del_p.P72fs|TRIB3_ENST00000485293.1_3'UTR	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	45					apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GCCCAGACTGCCCCCCTGCCT	0.627													15	229	---	---	---	---						-	368784	C	-	368784	7	5	21	1	0	1	0	1	0	0	0	0	16544	739	26	0	132	0	TRIB3	20	368784	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08		368784	62656736	759	2180										
RBCK1	10616	broad.mit.edu	37	chr20	398171	398171	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccctgctgttctctgcaggCtgtgggtgagcgtggaggat	16	10	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:398171C>G	ENST00000356286.5	+	3	874	c.167_splice	c.e3-1	p.L57_splice	RBCK1_ENST00000353660.3_Splice_Site_p.L15_splice|RBCK1_ENST00000382181.2_5'UTR	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	57	Interaction with IRF3.|Interaction with TAB2.|Ubiquitin-like.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				TCTCTGCAGGCTGTGGGTGAG	0.592													17	58					0	0	1	0	0	G	398171	C	G	398171	5	3	21	1	0	0	0	0	0	0	1	0	13158	811	28	5	198	5	RBCK1	20	398171	Splice_Site	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	29387	398171	62627349	760	2181										
PRNP	5621	broad.mit.edu	37	chr20	4680506	4680506	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcgcgtggttgagcagatgTgtatcacccagtacgagagg	15	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:4680506T>G	ENST00000379440.4	+	2	927	c.640T>G	c.(640-642)Tgt>Ggt	p.C214G	PRNP_ENST00000430350.2_Missense_Mutation_p.C214G	NM_000311.3|NM_001080121.1|NM_001080122.1|NM_001080123.1|NM_001271561.1|NM_183079.2	NP_000302.1|NP_001073590.1|NP_001073591.1|NP_001073592.1|NP_001258490.1|NP_898902.1	P04156	PRIO_HUMAN	prion protein	214	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	14					Tetracycline(DB00759)	TGAGCAGATGTGTATCACCCA	0.522													67	36					0	0	1	0	0	G	4680506	T	G	4680506	3	3	21	1	0	0	0	0	1	0	0	0	12595	1696	59	4	642	4	PRNP	20	4680506	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4282335	4680506	58345014	761	2182										
BCL2L1	598	broad.mit.edu	37	chr20	30253853	30253853	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctggccctttcggctctcggCtgctgcattgttcccataga	10	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:30253853C>T	ENST00000307677.4	-	3	1011	c.601G>A	c.(601-603)Gcc>Acc	p.A201T	BCL2L1_ENST00000420653.1_Missense_Mutation_p.A201T|BCL2L1_ENST00000376055.4_Missense_Mutation_p.A138T|BCL2L1_ENST00000376062.2_Missense_Mutation_p.A201T	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	201					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CGGCTCTCGGCTGCTGCATTG	0.557													38	110					0	0	1	0	0	T	30253853	C	T	30253853	3	4	21	1	0	0	0	0	1	0	0	0	1365	797	28	3	104	3	BCL2L1	20	30253853	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	25573347	30253853	32771667	762	2183										
E2F1	1869	broad.mit.edu	37	chr20	32267721	32267721	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctcagcagctccaggaagcGcttggtggtcagattcagtg	14	10	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:32267721G>A	ENST00000343380.5	-	3	551	c.412C>T	c.(412-414)Cgc>Tgc	p.R138C		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	138					apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						TCCAGGAAGCGCTTGGTGGTC	0.602													32	60					0	0	1	0	0	A	32267721	G	A	32267721	3	1	21	1	0	0	0	0	1	0	0	0	4892	1087	38	1	921	1	E2F1	20	32267721	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2013868	32267721	30757799	763	2184										
PPP1R16B	26051	broad.mit.edu	37	chr20	37546949	37546949	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggggatgtctggaaggtgcaTgaggtgcctgactacagcat	16	7	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:37546949T>C	ENST00000299824.1	+	11	1533	c.1344T>C	c.(1342-1344)caT>caC	p.H448H	PPP1R16B_ENST00000373331.2_Silent_p.H406H	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	448					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				GGAAGGTGCATGAGGTGCCTG	0.627													11	349					0	0	1	0	0	C	37546949	T	C	37546949	2	2	21	1	0	0	0	0	0	0	0	1	12414	1461	51	4		4	PPP1R16B	20	37546949	Silent	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	5279228	37546949	25478571	764	2185										
PTPRT	11122	broad.mit.edu	37	chr20	40980772	40980772	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gacagggggcccaaagccctTtgctgtgctggccttgatgg	15	11	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:40980772T>C	ENST00000373198.3	-	10	1949	c.1714A>G	c.(1714-1716)Aag>Gag	p.K572E	PTPRT_ENST00000373187.1_Missense_Mutation_p.K572E|PTPRT_ENST00000373190.1_Missense_Mutation_p.K572E|PTPRT_ENST00000373193.3_Missense_Mutation_p.K572E|PTPRT_ENST00000373201.1_Missense_Mutation_p.K572E|PTPRT_ENST00000373184.1_Missense_Mutation_p.K572E|PTPRT_ENST00000356100.2_Missense_Mutation_p.K572E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	572	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCAAAGCCCTTTGCTGTGCTG	0.517													48	101					0	0	1	0	0	C	40980772	T	C	40980772	3	2	21	1	0	0	0	0	1	0	0	0	12863	1850	64	4	2760	4	PTPRT	20	40980772	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	3433823	40980772	22044748	765	2186										
MYBL2	4605	broad.mit.edu	37	chr20	42333926	42333926	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcgctgacatccaccccagTgtgcagccagaaggtggtgg	13	13	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:42333926T>C	ENST00000217026.4	+	9	1560	c.1433T>C	c.(1432-1434)gTg>gCg	p.V478A	MYBL2_ENST00000396863.4_Missense_Mutation_p.V454A	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	478						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TCCACCCCAGTGTGCAGCCAG	0.557													28	67					0	0	1	0	0	C	42333926	T	C	42333926	3	2	21	1	0	0	0	0	1	0	0	0	10057	1696	59	4	1467	4	MYBL2	20	42333926	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1353154	42333926	20691594	766	2187										
SEMG1	6406	broad.mit.edu	37	chr20	43837242	43837242	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggatctcatgggggattggAtattgtaattatagagcagg	14	3	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:43837242A>G	ENST00000372781.3	+	2	1361	c.1304A>G	c.(1303-1305)gAt>gGt	p.D435G	SEMG1_ENST00000244069.6_Missense_Mutation_p.D375G	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GGGGGATTGGATATTGTAATT	0.403													121	90					0	0	1	0	0	G	43837242	A	G	43837242	3	3	21	1	0	0	0	0	1	0	0	0	14097	333	12	4	1310	4	SEMG1	20	43837242	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1503316	43837242	19188278	767	2188										
MATN4	8785	broad.mit.edu	37	chr20	43933378	43933378	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctcgaactcgaaagggcgcaCgctgcgggagctgtcaatca	13	12	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:43933378C>T	ENST00000537548.1	-	4	377	c.133G>A	c.(133-135)Gtg>Atg	p.V45M	MATN4_ENST00000372751.4_Intron|MATN4_ENST00000372754.1_Missense_Mutation_p.V45M|MATN4_ENST00000360607.5_Missense_Mutation_p.V45M|MATN4_ENST00000372756.1_Missense_Mutation_p.V45M|MATN4_ENST00000353917.5_Missense_Mutation_p.V45M|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000342716.4_Missense_Mutation_p.V45M			O95460	MATN4_HUMAN	matrilin 4	45	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AAAGGGCGCACGCTGCGGGAG	0.632													19	41					0	0	1	0	0	T	43933378	C	T	43933378	3	4	21	1	0	0	0	0	1	0	0	0	9385	536	19	1	1644	1	MATN4	20	43933378	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	96136	43933378	19092142	768	2189										
ZNFX1	57169	broad.mit.edu	37	chr20	47892343	47892343	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttggtatgggaattcctggGcctggcatccagatgaggtc	15	8	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:47892343G>A	ENST00000396105.1	-	2	280	c.34C>T	c.(34-36)Ccc>Tcc	p.P12S	ZNFX1_ENST00000371752.1_Missense_Mutation_p.P12S|ZNFX1_ENST00000371754.4_Missense_Mutation_p.P12S	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	12							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAATTCCTGGGCCTGGCATCC	0.423													24	63					0	0	1	0	0	A	47892343	G	A	47892343	3	1	21	1	0	0	0	0	1	0	0	0	18246	1203	42	3	5774	3	ZNFX1	20	47892343	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3958965	47892343	15133177	769	2190										
ATP9A	10079	broad.mit.edu	37	chr20	50255979	50255979	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgccaggggtcctcagctgcAtggaagactggtctcggccc	14	14	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:50255979A>G	ENST00000338821.5	-	15	1835	c.1571T>C	c.(1570-1572)aTg>aCg	p.M524T	ATP9A_ENST00000402822.1_Missense_Mutation_p.M403T|ATP9A_ENST00000311637.5_Missense_Mutation_p.M388T	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	524					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CCTCAGCTGCATGGAAGACTG	0.552											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	100					0	0	1	0	0	G	50255979	A	G	50255979	3	3	21	1	0	0	0	0	1	0	0	0	1196	217	8	4	1628	4	ATP9A	20	50255979	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2363636	50255979	12769541	770	2191										
GNAS	2778	broad.mit.edu	37	chr20	57428472	57428472	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccagccgaagagatggagaCcgaaccgcctcacaacgagc	11	15	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:57428472C>T	ENST00000371100.4	+	1	704	c.152C>T	c.(151-153)aCc>aTc	p.T51I	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371099.2_Missense_Mutation_p.T51I|GNAS_ENST00000371102.4_Missense_Mutation_p.T51I|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000464624.2_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GAGATGGAGACCGAACCGCCT	0.652			Mis		pituitary adenoma		"McCune-Albright syndrome; pseudohypoparathyroidism, type IA"			TSP Lung(22;0.16)			16	4					0	0	1	0	0	T	57428472	C	T	57428472	3	4	21	1	0	0	0	0	1	0	0	0	6551	507	18	3	896	3	GNAS	20	57428472	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	7172493	57428472	5597048	771	2192										
ZNF831	128611	broad.mit.edu	37	chr20	57767907	57767907	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggaagtgcggccagagaagGctgaagatgttctcccagga	15	8	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:57767907G>A	ENST00000371030.2	+	1	1833	c.1833G>A	c.(1831-1833)agG>agA	p.R611R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	611						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCCAGAGAAGGCTGAAGATGT	0.597													46	141					0	0	1	0	0	A	57767907	G	A	57767907	2	1	21	1	0	0	0	0	0	0	0	1	18231	1194	42	3		3	ZNF831	20	57767907	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	339435	57767907	5257613	772	2193										
LAMA5	3911	broad.mit.edu	37	chr20	60927343	60927343	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgtgagtactcggtggtgcaGatggccgcgtcgtcccgtgt	16	11	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:60927343G>A	ENST00000252999.3	-	4	708	c.642C>T	c.(640-642)atC>atT	p.I214I	LAMA5_ENST00000370692.3_Silent_p.I214I|LAMA5_ENST00000370677.3_Silent_p.I214I	NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	214	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGTGGTGCAGATGGCCGCGT	0.697													19	54					0	0	1	0	0	A	60927343	G	A	60927343	2	1	21	1	0	0	0	0	0	0	0	1	8647	932	33	3		3	LAMA5	20	60927343	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3159436	60927343	2098177	773	2194										
GMEB2	26205	broad.mit.edu	37	chr20	62236098	62236098	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctaggacggcttcctacctAacacggcttccttgagctgg	10	14	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62236098A>G	ENST00000266068.1	-	2	705	c.227T>C	c.(226-228)tTa>tCa	p.L76S	GMEB2_ENST00000370077.1_Missense_Mutation_p.L76S|GMEB2_ENST00000370069.1_Missense_Mutation_p.L25S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	76					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			CTTCCTACCTAACACGGCTTC	0.572													23	128					0	0	1	0	0	G	62236098	A	G	62236098	3	3	21	1	0	0	0	0	1	0	0	0	6529	372	13	4	1397	4	GMEB2	20	62236098	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1308755	62236098	789422	774	2195										
RTEL1	51750	broad.mit.edu	37	chr20	62328274	62328274	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agcggctggtgtgcgcccagTgccccccaggcacctttgtg	14	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62328274T>A	ENST00000318100.4	+	36	4888	c.4061T>A	c.(4060-4062)gTg>gAg	p.V1354E	TNFRSF6B_ENST00000369996.1_Missense_Mutation_p.C52S|RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.V1354E			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	0					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTGCGCCCAGTGCCCCCCAGG	0.701													32	22					0	0	1	0	0	A	62328274	T	A	62328274	3	1	21	1	0	0	0	0	1	0	0	0	13771	1696	59	4		4	RTEL1	20	62328274	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	92176	62328274	697246	775	2196										
UCKL1	54963	broad.mit.edu	37	chr20	62571740	62571740	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctcactcaccaggagcacGcgcactgccatcatggccgc	11	17	3	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62571740G>A	ENST00000369908.5	-	13	1655	c.1356C>T	c.(1354-1356)cgC>cgT	p.R452R	UCKL1_ENST00000369892.3_Silent_p.R467R|UCKL1_ENST00000358711.3_3'UTR|UCKL1_ENST00000354216.6_Silent_p.R467R	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	467					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCAGGAGCACGCGCACTGCCA	0.632													18	42					0	0	1	0	0	A	62571740	G	A	62571740	2	1	21	1	0	0	0	0	0	0	0	1	16984	1074	38	1		1	UCKL1	20	62571740	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	243466	62571740	453780	776	2197										
MYT1	4661	broad.mit.edu	37	chr20	62839359	62839359	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaggaggaggaggaagaggaGgaggaggaggatgaagaaga	23	0	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62839359G>A	ENST00000536311.1	+	7	1174	c.810G>A	c.(808-810)gaG>gaA	p.E270E	MYT1_ENST00000328439.1_Silent_p.E270E|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	270	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaagaggaggaggaggagg	0.577													15	21					0	0	1	0	0	A	62839359	G	A	62839359	2	1	21	1	0	0	0	0	0	0	0	1	10153	991	35	3		3	MYT1	20	62839359	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	267619	62839359	186161	777	2198										
CHODL	140578	broad.mit.edu	37	chr21	19629084	19629084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tggagatgggcaaacatctgGtgcctgcccagatctctacc	11	12	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:19629084G>A	ENST00000299295.2	+	2	729	c.338G>A	c.(337-339)gGt>gAt	p.G113D	CHODL_ENST00000400127.1_Missense_Mutation_p.G72D|CHODL_ENST00000400131.1_Missense_Mutation_p.G72D|CHODL_ENST00000400135.1_Missense_Mutation_p.G72D|CHODL_ENST00000543733.1_Missense_Mutation_p.G94D|CHODL_ENST00000338326.3_Missense_Mutation_p.G72D|CHODL_ENST00000400128.1_Missense_Mutation_p.G72D	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	113	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CAAACATCTGGTGCCTGCCCA	0.507													45	61					0	0	1	0	0	A	19629084	G	A	19629084	3	1	21	1	0	0	0	0	1	0	0	0	3386	1261	44	3	344	3	CHODL	21	19629084	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08		19629084	28500811	778	2199										
KRTAP13-4	284827	broad.mit.edu	37	chr21	31802764	31802764	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtcagaagacctgctgggaGcccgccagctgccagaaatc	12	13	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:31802764G>T	ENST00000334068.2	+	1	193	c.171G>T	c.(169-171)gaG>gaT	p.E57D		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	57	4 X 10 AA approximate repeats.					intermediate filament				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						CCTGCTGGGAGCCCGCCAGCT	0.617													40	38					1.96642e-18	2.15299e-18	1	1	0	T	31802764	G	T	31802764	3	4	21	1	0	0	0	0	1	0	0	0	8567	962	34	5	173	5	KRTAP13-4	21	31802764	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	12173680	31802764	16327131	779	2200										
BRWD1	54014	broad.mit.edu	37	chr21	40574467	40574467	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttttaacctcttcggcttgaGgtttctggccaaacatatga	8	9	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:40574467G>T	ENST00000342449.3	-	38	4447	c.4369C>A	c.(4369-4371)Ctc>Atc	p.L1457I	BRWD1_ENST00000333229.2_Missense_Mutation_p.L1457I|BRWD1_ENST00000380800.3_Missense_Mutation_p.L1457I	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTCGGCTTGAGGTTTCTGGCC	0.358													12	19					3.07112e-06	3.17614e-06	1	1	0	T	40574467	G	T	40574467	3	4	21	1	0	0	0	0	1	0	0	0	1527	1000	35	5	2852	5	BRWD1	21	40574467	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	8771703	40574467	7555428	780	2201										
TRPM2	7226	broad.mit.edu	37	chr21	45810891	45810891	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cccgcagtgagatcttcatgGatgagtggcagtggaaggta	15	7	2	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:45810891G>A	ENST00000397928.1	+	10	1868	c.1423G>A	c.(1423-1425)Gat>Aat	p.D475N	TRPM2_ENST00000300481.9_Missense_Mutation_p.D475N|TRPM2_ENST00000397932.2_Missense_Mutation_p.D475N|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.D475N	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	475						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GATCTTCATGGATGAGTGGCA	0.582													58	57					0	0	1	0	0	A	45810891	G	A	45810891	3	1	21	1	0	0	0	0	1	0	0	0	16646	1174	41	3	1461	3	TRPM2	21	45810891	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5236424	45810891	2319004	781	2202										
KRTAP10-4	386672	broad.mit.edu	37	chr21	45994016	45994016	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagcctgtgtgctgtgtgccCgtctgctgtggggattcttc	14	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:45994016C>A	ENST00000400374.3	+	1	411	c.381C>A	c.(379-381)ccC>ccA	p.P127P	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	127	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GCTGTGTGCCCGTCTGCTGTG	0.647													20	210					2.94398e-08	3.08099e-08	1	1	0	A	45994016	C	A	45994016	2	1	21	1	0	0	0	0	0	0	0	1	8553	639	23	5		5	KRTAP10-4	21	45994016	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	183125	45994016	2135879	782	2203										
MCM3AP	8888	broad.mit.edu	37	chr21	47662805	47662805	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tattttttcaaatcgtttttAaaaaaatacacacatatctg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:47662805delA	ENST00000397708.1	-	26	5591	c.5337delT	c.(5335-5337)ttfs	p.F1779fs	MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000432735.1_RNA|MCM3AP-AS1_ENST00000444998.1_RNA|MCM3AP_ENST00000291688.1_Frame_Shift_Del_p.F1779fs|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000421927.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1779					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding	p.K1780fs*5(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					AATCGTTTTTAAAAAAATACA	0.433													45	75	---	---	---	---						-	47662805	A	-	47662805	7	5	21	1	0	1	0	1	0	0	0	0	9437	359	13	0	621	0	MCM3AP	21	47662805	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1668789	47662805	467090	783	2204										
MICAL3	57553	broad.mit.edu	37	chr22	18364029	18364029	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggggaggagacagggtgatcActtttttggggcaggtccga	18	6	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:18364029A>T	ENST00000429452.1	-	17	2634	c.2282T>A	c.(2281-2283)gTg>gAg	p.V761E	MICAL3_ENST00000383094.3_Intron|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000585038.1_Missense_Mutation_p.V761E|MICAL3_ENST00000441493.2_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000414725.2_Intron|MICAL3_ENST00000207726.7_Intron	NM_001136004.1	NP_001129476.1	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1248						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CAGGGTGATCACTTTTTTGGG	0.542													81	98					0	0	1	0	0	T	18364029	A	T	18364029	3	4	21	1	0	0	0	0	1	0	0	0	9618	159	6	4	4527	4	MICAL3	22	18364029	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08		18364029	32940537	784	2205										
TUBA8	51807	broad.mit.edu	37	chr22	18609160	18609161	+	Frame_Shift_Del	DEL	CA	CA	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcagggcttcctgattttcCacagttttggtgggggcact							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:18609160_18609161delCA	ENST00000330423.3	+	4	488_489	c.415_416delCA	c.(415-417)cfs	p.H139fs	TUBA8_ENST00000316027.6_Frame_Shift_Del_p.H73fs	NM_018943.2	NP_061816.1	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	139					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	14						CCTGATTTTCCACAGTTTTGGT	0.52													65	135	---	---	---	---						-	18609161	CA	-	18609160	7	5	21	1	0	1	0	1	0	0	0	0	16811	594	21	0	429	0	TUBA8	22	18609160	Frame_Shift_Del	DEL	CA	TCGA-N7-A4Y0-01A-12D-A28R-08	245131	18609160	32695406	785	2206										
CLDN5	7122	broad.mit.edu	37	chr22	19511475	19511475	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cacgcaggtggtgcactgcgCgcccgccagggtcacgaaga	15	14	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:19511475C>T	ENST00000406028.1	-	2	1619	c.559G>A	c.(559-561)Gcg>Acg	p.A187T	CLDN5_ENST00000403084.1_Missense_Mutation_p.A187T|CLDN5_ENST00000413119.2_Missense_Mutation_p.A187T			O00501	CLD5_HUMAN	claudin 5	102					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			liver(1)|lung(2)|prostate(1)	4	Colorectal(54;0.0993)					GTGCACTGCGCGCCCGCCAGG	0.736													8	8					0	0	1	0	0	T	19511475	C	T	19511475	3	4	21	1	0	0	0	0	1	0	0	0	3511	768	27	1	356	1	CLDN5	22	19511475	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	902315	19511475	31793091	786	2207										
GNB1L	0	broad.mit.edu	37	chr22	19776481	19776481	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtgagttcatgagtcccacgCacctgtgagagttgggagag	15	8	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:19776481C>G	ENST00000329517.6	-	8	971	c.735G>C	c.(733-735)gtG>gtC	p.V245V	GNB1L_ENST00000460402.1_5'UTR|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000403325.1_Silent_p.V245V	NM_053004.2	NP_443730.1	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	245					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	12	Colorectal(54;0.0993)					GAGTCCCACGCACCTGTGAGA	0.642													26	58					0	0	1	0	0	G	19776481	C	G	19776481	2	3	21	1	0	0	0	0	0	0	0	1	6557	697	25	5		5	GNB1L	22	19776481	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	265006	19776481	31528085	787	2208										
ARVCF	421	broad.mit.edu	37	chr22	19959451	19959451	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcctctcctgcagagctggcGccccgtggcctccgctccct	11	20	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:19959451G>A	ENST00000263207.3	-	18	3030	c.2739C>T	c.(2737-2739)ggC>ggT	p.G913G	ARVCF_ENST00000344269.3_Silent_p.G850G|ARVCF_ENST00000406522.1_Silent_p.G844G|ARVCF_ENST00000406259.1_Silent_p.G907G|ARVCF_ENST00000401994.1_Silent_p.G850G	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	913					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CAGAGCTGGCGCCCCGTGGCC	0.652													22	40					0	0	1	0	0	A	19959451	G	A	19959451	2	1	21	1	0	0	0	0	0	0	0	1	1002	1074	38	1		1	ARVCF	22	19959451	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	182970	19959451	31345115	788	2209										
THAP7	80764	broad.mit.edu	37	chr22	21354970	21354970	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tctgagccggctgacttcagCggggccaggtgggtaactgt					rs426938	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:21354970delC	ENST00000215742.4	-	3	517	c.343delG	c.(343-345)ctfs	p.A115fs	THAP7_ENST00000399133.2_Frame_Shift_Del_p.A115fs	NM_030573.2	NP_085050.2	Q9BT49	THAP7_HUMAN	THAP domain containing 7	115			A -> P (in dbSNP:rs426938).		negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding	p.A115P(1)		cervix(1)|lung(2)|prostate(3)|skin(1)|stomach(1)	8	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CTGACTTCAGCGGGGCCAGGT	0.602													85	120	---	---	---	---						-	21354970	C	-	21354970	7	5	21	1	0	1	0	1	0	0	0	0	15908	768	27	0	594	0	THAP7	22	21354970	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1395519	21354970	29949596	789	2210										
GGT5	2687	broad.mit.edu	37	chr22	24627387	24627387	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggataaagctgagaatggcaCcccctgcaggcggcggtggt							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:24627387delC	ENST00000327365.4	-	6	1282	c.866delG	c.(865-867)gtfs	p.G289fs	GGT5_ENST00000418439.2_Frame_Shift_Del_p.G212fs|GGT5_ENST00000263112.7_Frame_Shift_Del_p.G257fs|GGT5_ENST00000398292.3_Frame_Shift_Del_p.G289fs	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	289					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						GAGAATGGCACCCCCTGCAGG	0.677													2	4	---	---	---	---						-	24627387	C	-	24627387	7	5	21	1	0	1	0	1	0	0	0	0	6403	507	18	0	925	0	GGT5	22	24627387	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3272417	24627387	26677179	790	2211										
CCDC157	550631	broad.mit.edu	37	chr22	30771603	30771603	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggaggagaacgggcggctccAatcaatgctgtccaaaatcc	12	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:30771603A>G	ENST00000405659.1	+	10	2517	c.1808A>G	c.(1807-1809)cAa>cGa	p.Q603R	CCDC157_ENST00000338306.3_Missense_Mutation_p.Q603R|RP1-130H16.16_ENST00000332468.4_RNA			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	603										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						GGGCGGCTCCAATCAATGCTG	0.617													26	34					0	0	1	0	0	G	30771603	A	G	30771603	3	3	21	1	0	0	0	0	1	0	0	0	2808	130	5	4	1838	4	CCDC157	22	30771603	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	6144216	30771603	20532963	791	2212										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31836101	31836101	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggaaccagagcctggaggaTgcagaactgtggagataaga	16	6	0	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:31836101T>C	ENST00000397525.1	-	19	2946	c.2723A>G	c.(2722-2724)cAt>cGt	p.H908R	EIF4ENIF1_ENST00000382180.2_Missense_Mutation_p.H563R|EIF4ENIF1_ENST00000397523.1_Missense_Mutation_p.H884R|EIF4ENIF1_ENST00000344710.5_Missense_Mutation_p.H734R|EIF4ENIF1_ENST00000330125.5_Missense_Mutation_p.H908R	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	908						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCCTGGAGGATGCAGAACTGT	0.512													44	60					0	0	1	0	0	C	31836101	T	C	31836101	3	2	21	1	0	0	0	0	1	0	0	0	5063	1464	51	4	238	4	EIF4ENIF1	22	31836101	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1064498	31836101	19468465	792	2213										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31838994	31838994	+	Frame_Shift_Del	DEL	T	T	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttactgtcaccaagagctgcTtttccagatgctggctcctc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:31838994delT	ENST00000397525.1	-	16	2383	c.2160delA	c.(2158-2160)aafs	p.K720fs	EIF4ENIF1_ENST00000344710.5_Frame_Shift_Del_p.K546fs|EIF4ENIF1_ENST00000397523.1_Frame_Shift_Del_p.K696fs|EIF4ENIF1_ENST00000330125.5_Frame_Shift_Del_p.K720fs|EIF4ENIF1_ENST00000382180.2_Frame_Shift_Del_p.K375fs	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	720						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CAAGAGCTGCTTTTCCAGATG	0.463													74	82	---	---	---	---						-	31838994	T	-	31838994	7	5	21	1	0	1	0	1	0	0	0	0	5063	1606	56	0	813	0	EIF4ENIF1	22	31838994	Frame_Shift_Del	DEL	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2893	31838994	19465572	793	2214										
C22orf24	25775	broad.mit.edu	37	chr22	32330115	32330117	+	In_Frame_Del	DEL	AGA	AGA	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctggctgtcaggactcggAgaagatgttgctaatgtaag							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:32330115_32330117delAGA	ENST00000248984.3	-	3	636_638	c.470_472delTCT	c.(469-474)tcc>t	p.FS157del	C22orf24_ENST00000543051.1_In_Frame_Del_p.FS224del|C22orf24_ENST00000486651.1_5'UTR	NM_015372.1	NP_056187.1	Q9Y442	CV024_HUMAN	chromosome 22 open reading frame 24	157						integral to membrane				central_nervous_system(1)|urinary_tract(1)	2						CAGGACTCGGAGAAGATGTTGCT	0.571													13	21	---	---	---	---						-	32330117	AGA	-	32330115	7	5	21	1	0	1	0	1	0	0	0	0	2152	304	11	0	14	0	C22orf24	22	32330115	In_Frame_Del	DEL	AGA	TCGA-N7-A4Y0-01A-12D-A28R-08	491121	32330115	18974451	794	2215										
NPTXR	23467	broad.mit.edu	37	chr22	39222592	39222592	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccgggcactgagtaggagaaGggggtgccctggccggtgcc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:39222592delG	ENST00000333039.2	-	3	1134	c.1011delC	c.(1009-1011)ccfs	p.P337fs		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	337	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					AGTAGGAGAAGGGGGTGCCCT	0.652													68	107	---	---	---	---						-	39222592	G	-	39222592	7	5	21	1	0	1	0	1	0	0	0	0	10651	987	35	0	503	0	NPTXR	22	39222592	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	6892477	39222592	12081974	795	2216										
APOBEC3F	200316	broad.mit.edu	37	chr22	39441204	39441204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgagtcaggcaggggcccgcGtgaagattatggacgatgaa	16	7	1	4			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:39441204G>A	ENST00000308521.5	+	3	787	c.430G>A	c.(430-432)Gtg>Atg	p.V144M	APOBEC3G_ENST00000452957.2_Intron	NM_145298.5	NP_660341.2	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	149					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|skin(2)	16	Melanoma(58;0.04)					AGGGGCCCGCGTGAAGATTAT	0.597													36	51					0	0	1	0	0	A	39441204	G	A	39441204	3	1	21	1	0	0	0	0	1	0	0	0	790	1145	40	1	579	1	APOBEC3F	22	39441204	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	218612	39441204	11863362	796	2217										
MGAT3	4248	broad.mit.edu	37	chr22	39883622	39883622	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgccgcccagcaaggcggcCgaggagctccaccgggtgga	16	15	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:39883622C>T	ENST00000341184.6	+	2	485	c.270C>T	c.(268-270)gcC>gcT	p.A90A		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	90					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCAAGGCGGCCGAGGAGCTCC	0.701													36	57					0	0	1	0	0	T	39883622	C	T	39883622	2	4	21	1	0	0	0	0	0	0	0	1	9593	639	23	1		1	MGAT3	22	39883622	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	442418	39883622	11420944	797	2218										
L3MBTL2	83746	broad.mit.edu	37	chr22	41612173	41612173	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cgaccaaaaaagccaaagtcCtgcacaaggctgcctggtct	9	13	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:41612173C>A	ENST00000216237.5	+	4	585	c.427C>A	c.(427-429)Ctg>Atg	p.L143M	RP4-756G23.5_ENST00000451176.1_RNA|L3MBTL2_ENST00000489136.1_3'UTR|RP4-756G23.5_ENST00000441316.1_RNA	NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	143					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGCCAAAGTCCTGCACAAGGC	0.557													13	25					5.50884e-06	5.67048e-06	1	1	0	A	41612173	C	A	41612173	3	1	21	1	0	0	0	0	1	0	0	0	8630	680	24	5	441	5	L3MBTL2	22	41612173	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1728551	41612173	9692393	798	2219										
RANGAP1	5905	broad.mit.edu	37	chr22	41654017	41654017	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caggttgatgacccgcagcaGggggttgacagcgaaagcct	15	10	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:41654017G>A	ENST00000455915.2	-	6	2178	c.709C>T	c.(709-711)Ctg>Ttg	p.L237L	RANGAP1_ENST00000356244.3_Silent_p.L237L|RANGAP1_ENST00000405486.1_Silent_p.L237L|RANGAP1_ENST00000407260.4_Silent_p.L182L			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	237					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ACCCGCAGCAGGGGGTTGACA	0.627													35	36					0	0	1	0	0	A	41654017	G	A	41654017	2	1	21	1	0	0	0	0	0	0	0	1	13084	991	35	3		3	RANGAP1	22	41654017	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	41844	41654017	9650549	799	2220										
TOB2	10766	broad.mit.edu	37	chr22	41833282	41833282	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccaaacaggtctgcccggCgccggggcagcttgttgtac	13	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:41833282C>T	ENST00000327492.3	-	2	774	c.68G>A	c.(67-69)cGc>cAc	p.R23H		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	23					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						GTCTGCCCGGCGCCGGGGCAG	0.542													39	38					0	0	1	0	0	T	41833282	C	T	41833282	3	4	21	1	0	0	0	0	1	0	0	0	16407	768	27	1	970	1	TOB2	22	41833282	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	179265	41833282	9471284	800	2221										
TCF20	6942	broad.mit.edu	37	chr22	42606139	42606139	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggctgcataatcttggggatAaaaaggtccaaagaggtcac							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:42606139delA	ENST00000359486.3	-	1	5309	c.5173delT	c.(5173-5175)atfs	p.Y1725fs	TCF20_ENST00000335626.4_Frame_Shift_Del_p.Y1725fs|TCF20_ENST00000404876.1_Frame_Shift_Del_p.Y26fs	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TCTTGGGGATAAAAAGGTCCA	0.502													59	78	---	---	---	---						-	42606139	A	-	42606139	7	5	21	1	0	1	0	1	0	0	0	0	15749	362	13	0	747	0	TCF20	22	42606139	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	772857	42606139	8698427	801	2222										
TTLL12	23170	broad.mit.edu	37	chr22	43570304	43570304	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	agccagggtgggccctcgggGccacctgcccggcgcgcgat	17	16	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:43570304G>A	ENST00000216129.6	-	8	1203	c.1140C>T	c.(1138-1140)ggC>ggT	p.G380G		NM_015140.3	NP_055955.1	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	380	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				GGCCCTCGGGGCCACCTGCCC	0.657													67	124					0	0	1	0	0	A	43570304	G	A	43570304	2	1	21	1	0	0	0	0	0	0	0	1	16786	1190	42	3		3	TTLL12	22	43570304	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	964165	43570304	7734262	802	2223										
KIAA1644	85352	broad.mit.edu	37	chr22	44681537	44681537	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gaccttgcagatgtcgtagtTcattgccgagtaatacaaaa	9	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:44681537T>C	ENST00000381176.4	-	4	502	c.370A>G	c.(370-372)Aac>Gac	p.N124D		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	124						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				ATGTCGTAGTTCATTGCCGAG	0.557													26	266					0	0	1	0	0	C	44681537	T	C	44681537	3	2	21	1	0	0	0	0	1	0	0	0	8291	1783	62	4	237	4	KIAA1644	22	44681537	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1111233	44681537	6623029	803	2224										
IL17REL	400935	broad.mit.edu	37	chr22	50436618	50436618	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcttacggcagccggcccccGgccccgggcgccagcacagg	15	19	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:50436618G>A	ENST00000389983.2	-	10	986	c.722C>T	c.(721-723)cCg>cTg	p.P241L	IL17REL_ENST00000341280.5_Missense_Mutation_p.P241L	NM_001001694.2	NP_001001694.2	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	241										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		gccggcccccggccccgggcg	0.682													47	51					0	0	1	0	0	A	50436618	G	A	50436618	3	1	21	1	0	0	0	0	1	0	0	0	7687	1116	39	1	308	1	IL17REL	22	50436618	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5755081	50436618	867948	804	2225										
TTLL8	164714	broad.mit.edu	37	chr22	50488585	50488585	+	Frame_Shift_Del	DEL	A	A	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catccggaatgaccttgggcAaaaagtggaacttcttctct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:50488585delA	ENST00000266182.6	-	2	142	c.143delT	c.(142-144)tgfs	p.L48fs	TTLL8_ENST00000440475.1_Frame_Shift_Del_p.L48fs|TTLL8_ENST00000477219.1_5'UTR					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GACCTTGGGCAAAAAGTGGAA	0.572													20	20	---	---	---	---						-	50488585	A	-	50488585	7	5	21	1	0	1	0	1	0	0	0	0	16794	131	5	0	2412	0	TTLL8	22	50488585	Frame_Shift_Del	DEL	A	TCGA-N7-A4Y0-01A-12D-A28R-08	51967	50488585	815981	805	2226										
MAPK8IP2	23542	broad.mit.edu	37	chr22	51043378	51043378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccagcgaggaggaggcgggcGcggcgctgctaggcggcggt	22	11	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51043378G>A	ENST00000399908.2	+	3	1569	c.853G>A	c.(853-855)Gcg>Acg	p.A285T	MAPK8IP2_ENST00000442429.2_Intron|MAPK8IP2_ENST00000399912.1_Missense_Mutation_p.A285T|MAPK8IP2_ENST00000341339.4_Missense_Mutation_p.A171T|MAPK8IP2_ENST00000329492.3_Missense_Mutation_p.A550T|MAPK8IP2_ENST00000008876.5_Missense_Mutation_p.A256T	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	551	Ser-rich.				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGAGGCGGGCGCGGCGCTGCT	0.682													22	20					0	0	1	0	0	A	51043378	G	A	51043378	3	1	21	1	0	0	0	0	1	0	0	0	9334	1074	38	1	1758	1	MAPK8IP2	22	51043378	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	554793	51043378	261188	806	2227										
ARSA	410	broad.mit.edu	37	chr22	51065756	51065757	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcacctcctccaggggcaggINScccccccgggagctgggcac					rs74315455		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51065756_51065757insC	ENST00000547307.1	-	2	701_702	c.296_297insG	c.(295-297)gctfs	p.A99fs	ARSA_ENST00000395619.3_Frame_Shift_Ins_p.A101fs|ARSA_ENST00000216124.5_Frame_Shift_Ins_p.A101fs|ARSA_ENST00000356098.5_Frame_Shift_Ins_p.A101fs|ARSA_ENST00000453344.2_Frame_Shift_Ins_p.A15fs|ARSA_ENST00000547805.1_Frame_Shift_Ins_p.A99fs|ARSA_ENST00000395621.3_Frame_Shift_Ins_p.A101fs			P15289	ARSA_HUMAN	arylsulfatase A	99			G -> D (in MLD; adult type).|G -> V (in MLD; late-infantile form).			lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|skin(1)	9		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	CCAGGGGCAGGCCCCCCCGGGA	0.718													8	9	---	---	---	---						C	51065757	-	C	51065756	7	5	21	1	0	1	1	0	0	0	0	0	986	1190	42	0	1254	0	ARSA	22	51065756	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	22378	51065756	238810	807	2228										
ACR	49	broad.mit.edu	37	chr22	51178329	51178330	+	Frame_Shift_Ins	INS	-	-	C													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tcattgggccgggctgcctgINSccccactttaaggcaggcct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51178329_51178330insC	ENST00000216139.5	+	3	529_530	c.489_490insC	c.(487-492)ctcccafs	p.LP163fs	ACR_ENST00000529621.1_Frame_Shift_Ins_p.LP163fs	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	163	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGCTGCCTGCCCCACTTTAA	0.579													68	93	---	---	---	---						C	51178330	-	C	51178329	7	5	21	1	0	1	1	0	0	0	0	0	169	1306	46	0	499	0	ACR	22	51178329	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y0-01A-12D-A28R-08	112573	51178329	126237	808	2229										
PLCXD1	55344	broad.mit.edu	37	chrX	215973	215973	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcttcgtcagtgacgtcatcGcgctcaatcagaagctgctg	11	12	4	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:215973G>A	ENST00000381657.2	+	7	1457	c.943G>A	c.(943-945)Gcg>Acg	p.A315T	PLCXD1_ENST00000399012.1_Missense_Mutation_p.A315T|PLCXD1_ENST00000381663.3_Missense_Mutation_p.A315T	NM_018390.3	NP_060860.1	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 1	315					intracellular signal transduction|lipid metabolic process		phospholipase C activity			endometrium(3)|large_intestine(1)|lung(7)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGACGTCATCGCGCTCAATCA	0.617													26	35					0	0	1	0	0	A	215973	G	A	215973	3	1	21	1	0	0	0	0	1	0	0	0	12088	1087	38	1	965	1	PLCXD1	23	215973	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08		215973	155054587	809	2230										
SLC25A6	293	broad.mit.edu	37	chrX	1508427	1508427	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	actgcgtgtgcttgtccacgCcccccaggaagatctgcttg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:1508427delC	ENST00000381401.5	-	2	1019	c.305delG	c.(304-306)gcfs	p.G102fs	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	102					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CTTGTCCACGCCCCCCAGGAA	0.607													101	189	---	---	---	---						-	1508427	C	-	1508427	7	5	21	1	0	1	0	1	0	0	0	0	14567	739	26	0	603	0	SLC25A6	23	1508427	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	1292454	1508427	153762133	810	2231										
ARSD	414	broad.mit.edu	37	chrX	2828698	2828698	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtccccgatgtccacaactcAcctttgtaaattccgttcca	5	15	1	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:2828698A>G	ENST00000381154.1	-	7	1211		c.e7+1			NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D							lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCCACAACTCACCTTTGTAAA	0.453													18	236					0	0	1	0	0	G	2828698	A	G	2828698	5	3	21	1	0	0	0	0	0	0	1	0	988	173	6	4	660	4	ARSD	23	2828698	Splice_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1320271	2828698	152441862	811	2232										
ARSE	415	broad.mit.edu	37	chrX	2854881	2854883	+	In_Frame_Del	DEL	AGA	AGA	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctgtccccaggagcaagggcAgaaggtcttggccgtcaatc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:2854881_2854883delAGA	ENST00000545496.1	-	11	1677_1679	c.1386_1388delTCT	c.(1384-1389)ctg>ct	p.LL462del	ARSE_ENST00000540563.1_In_Frame_Del_p.LL392del|ARSE_ENST00000381134.3_In_Frame_Del_p.LL437del			P51690	ARSE_HUMAN	arylsulfatase E (chondrodysplasia punctata 1)	437					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GAGCAAGGGCAGAAGGTCTTGGC	0.562													20	25	---	---	---	---						-	2854883	AGA	-	2854881	7	5	21	1	0	1	0	1	0	0	0	0	989	188	7	0	464	0	ARSE	23	2854881	In_Frame_Del	DEL	AGA	TCGA-N7-A4Y0-01A-12D-A28R-08	26183	2854881	152415679	812	2233										
CLCN4	0	broad.mit.edu	37	chrX	10153098	10153098	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caatgcgggagcgatgagtgGctctggaaacctgatggatt	15	7	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:10153098G>A	ENST00000380833.4	+	3	417	c.26G>A	c.(25-27)gGc>gAc	p.G9D	CLCN4_ENST00000380829.1_Missense_Mutation_p.G9D|CLCN4_ENST00000421085.2_Intron	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	9						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCGATGAGTGGCTCTGGAAAC	0.517													5	107					0	0	1	0	0	A	10153098	G	A	10153098	3	1	21	1	0	0	0	0	1	0	0	0	3488	1203	42	3	28	3	CLCN4	23	10153098	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	7298217	10153098	145117462	813	2234										
FRMPD4	9758	broad.mit.edu	37	chrX	12693029	12693029	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtcattcagccttaccctgTaagtgttctgtgaataaaag	8	8	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:12693029T>C	ENST00000380682.1	+	5	974		c.e5+2			NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4						positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCTTACCCTGTAAGTGTTCTG	0.393													5	114					0	0	1	0	0	C	12693029	T	C	12693029	5	2	21	1	0	0	0	0	0	0	1	0	6093	1652	57	4	488	4	FRMPD4	23	12693029	Splice_Site	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2539931	12693029	142577531	814	2235										
ARX	170302	broad.mit.edu	37	chrX	25031207	25031207	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcgccgtccttgccctcaGcgtcttccgggtgcagcagc	11	18	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:25031207G>T	ENST00000379044.4	-	2	1115	c.905C>A	c.(904-906)gCt>gAt	p.A302D		NM_139058.2	NP_620689.1	Q96QS3	ARX_HUMAN	aristaless related homeobox	302						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(1)	4						CTTGCCCTCAGCGTCTTCCGG	0.697													5	7					0.0215528	0.0217012	1	1	0	T	25031207	G	T	25031207	3	4	21	1	0	0	0	0	1	0	0	0	1003	971	34	5	799	5	ARX	23	25031207	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	12338178	25031207	130239353	815	2236										
CXorf21	80231	broad.mit.edu	37	chrX	30578299	30578299	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ataaacttgccagatgatttGcagctcacgtagagacttct	8	9	2	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:30578299G>T	ENST00000378962.3	-	3	496	c.174C>A	c.(172-174)tgC>tgA	p.C58*		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	58										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						CAGATGATTTGCAGCTCACGT	0.468													101	134					1.61169e-53	1.82852e-53	1	1	0	T	30578299	G	T	30578299	4	4	21	1	0	0	0	0	0	1	0	0	4124	1311	46	5	735	5	CXorf21	23	30578299	Nonsense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	5547092	30578299	124692261	816	2237										
FAM47C	442444	broad.mit.edu	37	chrX	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gtctccgcccggagcctcccAatactggagtgtcccatctc	9	17	2	0	rs145580328	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642													7	169					0	0	1	0	0	G	37028425	A	G	37028425	3	3	21	1	0	0	0	0	1	0	0	0	5606	130	5	4	1944	4	FAM47C	23	37028425	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	6450126	37028425	118242135	817	2238										
RBM10	8241	broad.mit.edu	37	chrX	47030467	47030469	+	In_Frame_Del	DEL	GGC	GGC	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gggctccgagactcagcgtaGgcggcggcggcggcacaggc							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:47030467_47030469delGGC	ENST00000377604.3	+	4	984_986	c.242_244delGGC	c.(241-246)agg>a	p.RR83del	RBM10_ENST00000329236.7_Intron|RBM10_ENST00000468791.1_3'UTR|RBM10_ENST00000345781.6_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	83	Poly-Arg.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding	p.R85delR(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						ACTCAGCGTAGGCGGCGGCGGCG	0.68													26	40	---	---	---	---						-	47030469	GGC	-	47030467	7	5	21	1	0	1	0	1	0	0	0	0	13162	1000	35	0	252	0	RBM10	23	47030467	In_Frame_Del	DEL	GGC	TCGA-N7-A4Y0-01A-12D-A28R-08	10002042	47030467	108240093	818	2239										
CDK16	5127	broad.mit.edu	37	chrX	47085770	47085770	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccagaacctgctcatcaaCgagaggggagagctcaagct	11	13	3	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:47085770C>T	ENST00000457458.2	+	9	1323	c.903C>T	c.(901-903)aaC>aaT	p.N301N	CDK16_ENST00000357227.4_Silent_p.N295N|CDK16_ENST00000518022.1_Silent_p.N295N|CDK16_ENST00000276052.6_Silent_p.N369N	NM_033018.3	NP_148978.2	Q00536	CDK16_HUMAN	cyclin-dependent kinase 16	295	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)	11						TGCTCATCAACGAGAGGGGAG	0.587													17	20					0	0	1	0	0	T	47085770	C	T	47085770	2	4	21	1	0	0	0	0	0	0	0	1	3154	535	19	1		1	CDK16	23	47085770	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	55303	47085770	108184790	819	2240										
SSX5	6758	broad.mit.edu	37	chrX	48047159	48047159	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtccaggcatgtttcccccTtttgggtcctatgatggaga	12	10	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:48047159T>C	ENST00000311798.1	-	8	650	c.598A>G	c.(598-600)Agg>Ggg	p.R200G	SSX5_ENST00000347757.1_Missense_Mutation_p.R159G|SSX5_ENST00000376923.1_Missense_Mutation_p.R159G	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TGTTTCCCCCTTTTGGGTCCT	0.478													129	202					0	0	1	0	0	C	48047159	T	C	48047159	3	2	21	1	0	0	0	0	1	0	0	0	15263	1608	56	4	95	4	SSX5	23	48047159	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	961389	48047159	107223401	820	2241										
GATA1	2623	broad.mit.edu	37	chrX	48652397	48652397	+	Frame_Shift_Del	DEL	C	C	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcttcaggcctgacactgggCcccccaggtactgcccatct							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:48652397delC	ENST00000376670.3	+	6	1179	c.1068delC	c.(1066-1068)ggfs	p.G356fs	GATA1_ENST00000376665.3_Intron	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	356					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						TGACACTGGGCCCCCCAGGTA	0.647			"Mis, F"		megakaryoblastic leukemia of Downs Syndrome								7	15	---	---	---	---						-	48652397	C	-	48652397	7	5	21	1	0	1	0	1	0	0	0	0	6292	726	26	0	1086	0	GATA1	23	48652397	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y0-01A-12D-A28R-08	605238	48652397	106618163	821	2242										
CCNB3	85417	broad.mit.edu	37	chrX	50085296	50085296	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgcaagaaggataagttacaActccttggtgccactgcctt	9	10	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:50085296A>G	ENST00000376042.1	+	9	3910	c.3612A>G	c.(3610-3612)caA>caG	p.Q1204Q	CCNB3_ENST00000348603.2_Silent_p.Q100Q|CCNB3_ENST00000376038.1_Silent_p.Q100Q|CCNB3_ENST00000276014.7_Silent_p.Q1204Q			Q8WWL7	CCNB3_HUMAN	cyclin B3	1204					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					ATAAGTTACAACTCCTTGGTG	0.468													43	62					0	0	1	0	0	G	50085296	A	G	50085296	2	3	21	1	0	0	0	0	0	0	0	1	2936	40	2	4		4	CCNB3	23	50085296	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1432899	50085296	105185264	822	2243										
BMP15	9210	broad.mit.edu	37	chrX	50659512	50659512	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cctcctgtgtcccgtataagTatgttccaattagtgtcctt	7	11	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:50659512T>C	ENST00000252677.3	+	2	1084	c.1084T>C	c.(1084-1086)Tat>Cat	p.Y362H		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	362					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					CCCGTATAAGTATGTTCCAAT	0.463													45	60					0	0	1	0	0	C	50659512	T	C	50659512	3	2	21	1	0	0	0	0	1	0	0	0	1457	1638	57	4	1090	4	BMP15	23	50659512	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	574216	50659512	104611048	823	2244										
TSPYL2	64061	broad.mit.edu	37	chrX	53111865	53111865	+	Frame_Shift_Del	DEL	G	G	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	acaggtgctggccgatatgaGgggggtgggactgggccccg							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:53111865delG	ENST00000375442.4	+	1	317	c.185delG	c.(184-186)agfs	p.R62fs		NM_022117.3	NP_071400.1	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	62	Pro-rich.				cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	19						GCCGATATGAGGGGGGTGGGA	0.726													6	11	---	---	---	---						-	53111865	G	-	53111865	7	5	21	1	0	1	0	1	0	0	0	0	16720	1000	35	0	187	0	TSPYL2	23	53111865	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y0-01A-12D-A28R-08	2452353	53111865	102158695	824	2245										
KDM5C	8242	broad.mit.edu	37	chrX	53247577	53247577	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gttcagtttcactctcgtctGggcctgaagaagaaatggct	11	9	4	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:53247577G>T	ENST00000375401.3	-	3	764	c.232C>A	c.(232-234)Cag>Aag	p.Q78K	KDM5C_ENST00000375379.3_Missense_Mutation_p.Q78K|KDM5C_ENST00000404049.3_Missense_Mutation_p.Q78K|KDM5C_ENST00000452825.3_Intron|KDM5C_ENST00000375383.3_Intron	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	78					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						ACTCTCGTCTGGGCCTGAAGA	0.512			"N, F, S"		clear cell renal carcinoma								24	48					2.49675e-24	2.77874e-24	1	1	0	T	53247577	G	T	53247577	3	4	21	1	0	0	0	0	1	0	0	0	8177	1357	47	5	4644	5	KDM5C	23	53247577	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	135712	53247577	102022983	825	2246										
TRO	7216	broad.mit.edu	37	chrX	54948702	54948702	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggataggagaaatgactacgGatatagggtgcctctatttc	12	6	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:54948702G>T	ENST00000173898.7	+	2	135	c.23G>T	c.(22-24)gGa>gTa	p.G8V	TRO_ENST00000420798.2_Intron|TRO_ENST00000375041.2_Missense_Mutation_p.G8V|TRO_ENST00000319167.8_Missense_Mutation_p.G8V|TRO_ENST00000375022.4_Missense_Mutation_p.G8V|TRO_ENST00000399736.1_Missense_Mutation_p.G8V|TRO_ENST00000484031.1_3'UTR	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	8					embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						AATGACTACGGATATAGGGTG	0.532													8	11					1.12685e-05	1.1572e-05	1	1	0	T	54948702	G	T	54948702	3	4	21	1	0	0	0	0	1	0	0	0	16634	1174	41	2	25	2	TRO	23	54948702	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1701125	54948702	100321858	826	2247										
FAAH2	158584	broad.mit.edu	37	chrX	57337042	57337042	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ttaggtttgaggaagcgatgAaggaggctcatgctgtagat	15	4	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:57337042A>G	ENST00000374900.4	+	3	412	c.292A>G	c.(292-294)Aag>Gag	p.K98E		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	98				K -> R (in Ref. 1; BAB71007).		integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GGAAGCGATGAAGGAGGCTCA	0.393										HNSCC(52;0.14)			20	30					0	0	1	0	0	G	57337042	A	G	57337042	3	3	21	1	0	0	0	0	1	0	0	0	5385	247	9	4	302	4	FAAH2	23	57337042	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	2388340	57337042	97933518	827	2248										
HDAC8	55869	broad.mit.edu	37	chrX	71787851	71787851	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tatagctgctgcatagtcaaAtatcccttcagtggctgggc	10	10	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:71787851A>T	ENST00000439122.2	-	4	611	c.325T>A	c.(325-327)Ttt>Att	p.F109I	HDAC8_ENST00000429103.2_Intron|HDAC8_ENST00000373561.4_Missense_Mutation_p.F109I|HDAC8_ENST00000373554.1_Missense_Mutation_p.F109I|HDAC8_ENST00000478743.1_Intron|HDAC8_ENST00000373556.3_Missense_Mutation_p.F109I|HDAC8_ENST00000373573.3_Missense_Mutation_p.F109I|HDAC8_ENST00000373583.1_Intron|HDAC8_ENST00000373589.4_Intron|HDAC8_ENST00000373571.1_Missense_Mutation_p.F109I|HDAC8_ENST00000373559.4_Intron|HDAC8_ENST00000373560.2_Missense_Mutation_p.F109I	NM_001166419.1	NP_001159891.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	109	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	GCATAGTCAAATATCCCTTCA	0.478													34	64					0	0	1	0	0	T	71787851	A	T	71787851	3	4	21	1	0	0	0	0	1	0	0	0	7053	101	4	4	926	4	HDAC8	23	71787851	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	14450809	71787851	83482709	828	2249										
SLC16A2	6567	broad.mit.edu	37	chrX	73740968	73740968	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tccataccagctccttcaccAggtaaggctaagagttggtg	10	11	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:73740968A>G	ENST00000276033.5	+	2	962	c.797_splice	c.e2+1	p.S266_splice	SLC16A2_ENST00000587091.1_Splice_Site_p.S192_splice			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	192						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	CTCCTTCACCAGGTAAGGCTA	0.517													50	56					0	0	1	0	0	G	73740968	A	G	73740968	5	3	21	1	0	0	0	0	0	0	1	0	14462	202	7	4	802	4	SLC16A2	23	73740968	Splice_Site	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1953117	73740968	81529592	829	2250										
KIAA2022	340533	broad.mit.edu	37	chrX	73960123	73960123	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tttttatcaaagaaggtagaGcgagagtcctcgttataacc	9	7	1	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:73960123G>A	ENST00000373468.1	-	3	4920	c.4269C>T	c.(4267-4269)cgC>cgT	p.R1423R	KIAA2022_ENST00000055682.5_Silent_p.R1423R			Q5QGS0	K2022_HUMAN	KIAA2022	1423					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						AGAAGGTAGAGCGAGAGTCCT	0.443													59	73					0	0	1	0	0	A	73960123	G	A	73960123	2	1	21	1	0	0	0	0	0	0	0	1	8310	958	34	3		3	KIAA2022	23	73960123	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	219155	73960123	81310437	830	2251										
MAGEE1	57692	broad.mit.edu	37	chrX	75649801	75649801	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccccaagaccctatggaacAgaacgtagctgagctgttgc	11	12	0	3			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:75649801A>C	ENST00000361470.2	+	1	1756	c.1478A>C	c.(1477-1479)cAg>cCg	p.Q493P		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	493	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CCTATGGAACAGAACGTAGCT	0.493													38	43					0	0	1	0	0	C	75649801	A	C	75649801	3	2	21	1	0	0	0	0	1	0	0	0	9234	188	7	4	1480	4	MAGEE1	23	75649801	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	1689678	75649801	79620759	831	2252										
ATRX	546	broad.mit.edu	37	chrX	76889125	76889125	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	catccaattcaaagcagtatTaagaggacaaaccactaacg	6	10	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:76889125T>C	ENST00000373344.5	-	18	5099	c.4885A>G	c.(4885-4887)Aat>Gat	p.N1629D	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.N1591D	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1629	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	AAAGCAGTATTAAGAGGACAA	0.343			"Mis, F, N"		"Pancreatic neuroendocrine tumors, paediatric GBM"		ATR-X (alpha thalassemia/mental retardation) syndrome						26	41					0	0	1	0	0	C	76889125	T	C	76889125	3	2	21	1	0	0	0	0	1	0	0	0	1206	1754	61	4	2665	4	ATRX	23	76889125	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	1239324	76889125	78381435	832	2253										
BRWD3	254065	broad.mit.edu	37	chrX	79973119	79973119	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	accaccactcttctgctccaCgccatgagatctctttcagt	5	16	4	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:79973119C>T	ENST00000373275.4	-	19	2400	c.2184G>A	c.(2182-2184)gcG>gcA	p.A728A	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	728										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TTCTGCTCCACGCCATGAGAT	0.393													56	88					0	0	1	0	0	T	79973119	C	T	79973119	2	4	21	1	0	0	0	0	0	0	0	1	1528	523	19	1		1	BRWD3	23	79973119	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	3083994	79973119	75297441	833	2254										
CYLC1	1538	broad.mit.edu	37	chrX	83129489	83129489	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aagactacattcaatgaaaaAggggaaaaagcaagtacagg	10	5	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:83129489A>G	ENST00000329312.4	+	4	1810	c.1773A>G	c.(1771-1773)aaA>aaG	p.K591K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	591					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TCAATGAAAAAGGGGAAAAAG	0.418													32	25					0	0	1	0	0	G	83129489	A	G	83129489	2	3	21	1	0	0	0	0	0	0	0	1	4164	69	3	4		4	CYLC1	23	83129489	Silent	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	3156370	83129489	72141071	834	2255										
RPA4	29935	broad.mit.edu	37	chrX	96139445	96139445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ctaaggtccgaattcaggacGttgtaccgtgtaatgtgaac	11	8	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:96139445G>A	ENST00000373040.3	+	1	539	c.136G>A	c.(136-138)Gtt>Att	p.V46I	DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000355827.4_Intron|DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000373061.3_Intron|DIAPH2_ENST00000324765.8_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	46					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						AATTCAGGACGTTGTACCGTG	0.498								Other identified genes with known or suspected DNA repair function					38	40					0	0	1	0	0	A	96139445	G	A	96139445	3	1	21	1	0	0	0	0	1	0	0	0	13590	1145	40	1	138	1	RPA4	23	96139445	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	13009956	96139445	59131115	835	2256										
ARMCX2	9823	broad.mit.edu	37	chrX	100911796	100911796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ccccagtgtgagccccagggGttgctttcttggcagctgat	13	12	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:100911796G>A	ENST00000328766.5	-	5	1232	c.779C>T	c.(778-780)aCc>aTc	p.T260I	ARMCX2_ENST00000330154.2_Missense_Mutation_p.T260I|ARMCX2_ENST00000356824.4_Missense_Mutation_p.T260I	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	260	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						AGCCCCAGGGGTTGCTTTCTT	0.602													47	102					0	0	1	0	0	A	100911796	G	A	100911796	3	1	21	1	0	0	0	0	1	0	0	0	959	1261	44	3	1123	3	ARMCX2	23	100911796	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	4772351	100911796	54358764	836	2257										
ESX1	80712	broad.mit.edu	37	chrX	103495020	103495020	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggtggcagaggcgccatgggCggcccgggtggcagaggcgc	22	11	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:103495020C>T	ENST00000372588.4	-	4	1193	c.1110G>A	c.(1108-1110)ccG>ccA	p.P370P		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	370	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P370P(1)		endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GCGCCATGGGCGGCCCGGGTG	0.697													27	37					0	0	1	0	0	T	103495020	C	T	103495020	2	4	21	1	0	0	0	0	0	0	0	1	5291	755	27	1		1	ESX1	23	103495020	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2583224	103495020	51775540	837	2258										
MORC4	79710	broad.mit.edu	37	chrX	106184836	106184836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	ggagatagctgacgtggataCgtagccgcgtaagctttgcc	14	9	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:106184836C>T	ENST00000355610.4	-	17	2961	c.2687G>A	c.(2686-2688)cGt>cAt	p.R896H	MORC4_ENST00000255495.7_Silent_p.T883T|MORC4_ENST00000535534.1_Silent_p.T631T	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	896							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						GACGTGGATACGTAGCCGCGT	0.498													19	38					0	0	1	0	0	T	106184836	C	T	106184836	3	4	21	1	0	0	0	0	1	0	0	0	9752	536	19	1	130	1	MORC4	23	106184836	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2689816	106184836	49085724	838	2259										
RBM41	55285	broad.mit.edu	37	chrX	106332030	106332030	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cttggtaaaaactttccaggTtgttcatgggatcacctttg	9	8	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:106332030T>C	ENST00000372487.1	-	5	589	c.563A>G	c.(562-564)aAc>aGc	p.N188S	RBM41_ENST00000372479.3_Missense_Mutation_p.N188S|RBM41_ENST00000203616.8_Missense_Mutation_p.N212S	NM_001171080.1	NP_001164551.1	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	188							nucleotide binding|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	13						ACTTTCCAGGTTGTTCATGGG	0.408													31	45					0	0	1	0	0	C	106332030	T	C	106332030	3	2	21	1	0	0	0	0	1	0	0	0	13186	1725	60	4	699	4	RBM41	23	106332030	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	147194	106332030	48938530	839	2260										
COL4A6	1288	broad.mit.edu	37	chrX	107420159	107420159	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggcctggatttccaggaagGccttttagccctggcagccc	12	13	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:107420159G>A	ENST00000334504.7	-	28	2831	c.2598C>T	c.(2596-2598)ggC>ggT	p.G866G	COL4A6_ENST00000372216.4_Silent_p.G867G|COL4A6_ENST00000545689.1_Silent_p.G866G|COL4A6_ENST00000394872.2_Silent_p.G867G|COL4A6_ENST00000538570.1_Silent_p.G866G	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	867	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						TTCCAGGAAGGCCTTTTAGCC	0.532									Alport syndrome with Diffuse Leiomyomatosis				89	164					0	0	1	0	0	A	107420159	G	A	107420159	2	1	21	1	0	0	0	0	0	0	0	1	3718	1190	42	3		3	COL4A6	23	107420159	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	1088129	107420159	47850401	840	2261										
RGAG1	57529	broad.mit.edu	37	chrX	109694816	109694816	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgaagtaatgtccacaccgcTactgtcagtcccagatgctg	9	12	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:109694816T>C	ENST00000465301.2	+	3	1217	c.971T>C	c.(970-972)cTa>cCa	p.L324P	RGAG1_ENST00000540313.1_Missense_Mutation_p.L324P	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	324										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TCCACACCGCTACTGTCAGTC	0.502													36	364					0	0	1	0	0	C	109694816	T	C	109694816	3	2	21	1	0	0	0	0	1	0	0	0	13325	1522	53	4	973	4	RGAG1	23	109694816	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	2274657	109694816	45575744	841	2262										
LUZP4	51213	broad.mit.edu	37	chrX	114536597	114536597	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gagttagaagggacaaatgcTgaagaagaaaagaataaaag	12	2	0	5			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:114536597T>C	ENST00000451986.2	+	2	165	c.5T>C	c.(4-6)cTg>cCg	p.L2P	LUZP4_ENST00000371920.3_Silent_p.A44A			Q9P127	LUZP4_HUMAN	leucine zipper protein 4	0						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GGACAAATGCTGAAGAAGAAA	0.333													52	94					0	0	1	0	0	C	114536597	T	C	114536597	3	2	21	1	0	0	0	0	1	0	0	0	9132	1567	55	4	138	4	LUZP4	23	114536597	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	4841781	114536597	40733963	842	2263										
FRMD7	90167	broad.mit.edu	37	chrX	131212901	131212903	+	In_Frame_Del	DEL	TCC	TCC	-													0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgtcacctccaatgcagaatTcctcctcctactctccagca							TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:131212901_131212903delTCC	ENST00000298542.4	-	12	1317_1319	c.1142_1144delGGA	c.(1141-1146)aat>a	p.RN381del	FRMD7_ENST00000370879.1_In_Frame_Del_p.RN261del|FRMD7_ENST00000464296.1_In_Frame_Del_p.RN366del	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	381					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					aatgcagaattcctcctcctact	0.498													12	298	---	---	---	---						-	131212903	TCC	-	131212901	7	5	21	1	0	1	0	1	0	0	0	0	6089	1783	62	0	1004	0	FRMD7	23	131212901	In_Frame_Del	DEL	TCC	TCGA-N7-A4Y0-01A-12D-A28R-08	16676304	131212901	24057659	843	2264										
HS6ST2	90161	broad.mit.edu	37	chrX	132092544	132092544	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcctctactctggaatgccgGcggggacaggtggtgcggac	17	11	2	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:132092544G>A	ENST00000370836.2	-	2	502	c.87C>T	c.(85-87)cgC>cgT	p.R29R	HS6ST2_ENST00000521489.1_Silent_p.R29R	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	29						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					TGGAATGCCGGCGGGGACAGG	0.711													12	13					0	0	1	0	0	A	132092544	G	A	132092544	2	1	21	1	0	0	0	0	0	0	0	1	7411	1190	42	3		3	HS6ST2	23	132092544	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	879643	132092544	23178016	844	2265										
RBMX	27316	broad.mit.edu	37	chrX	135960091	135960091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tacccatgtgtcctccccgtGagggaggtcccctggttcct	11	15	0	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:135960091G>A	ENST00000562646.1	-	4	525	c.371C>T	c.(370-372)tCa>tTa	p.S124L	RBMX_ENST00000320676.7_Missense_Mutation_p.S124L|RBMX_ENST00000431446.3_Intron|RBMX_ENST00000570135.1_Intron|RBMX_ENST00000565438.1_5'UTR			P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked	124						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|urinary_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TCCTCCCCGTGAGGGAGGTCC	0.547													36	52					0	0	1	0	0	A	135960091	G	A	135960091	3	1	21	1	0	0	0	0	1	0	0	0	13202	1294	45	3	883	3	RBMX	23	135960091	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	3867547	135960091	19310469	845	2266										
ATP11C	286410	broad.mit.edu	37	chrX	138882232	138882232	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aacttacctggcaacagcctCaagactattactgtagatat	6	10	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:138882232C>A	ENST00000370557.1	-	8	1724	c.697G>T	c.(697-699)Gag>Tag	p.E233*	ATP11C_ENST00000359686.2_Nonsense_Mutation_p.E236*|ATP11C_ENST00000361648.2_Nonsense_Mutation_p.E236*|ATP11C_ENST00000370543.1_Nonsense_Mutation_p.E236*|ATP11C_ENST00000327569.3_Nonsense_Mutation_p.E236*			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	236					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					GCAACAGCCTCAAGACTATTA	0.368													35	68					2.40579e-17	2.60801e-17	1	1	0	A	138882232	C	A	138882232	4	1	21	1	0	0	0	0	0	1	0	0	1120	835	29	2	2847	2	ATP11C	23	138882232	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	2922141	138882232	16388328	846	2267										
PASD1	139135	broad.mit.edu	37	chrX	150840935	150840935	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gctgcaagagcagccactgaAgcataatgtcatcgtgggga	13	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:150840935A>C	ENST00000370357.4	+	14	1963	c.1718A>C	c.(1717-1719)aAg>aCg	p.K573T		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	573						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					cagccactgaagcaTAATGTC	0.522													31	39					0	0	1	0	0	C	150840935	A	C	150840935	3	2	21	1	0	0	0	0	1	0	0	0	11517	72	3	4	1768	4	PASD1	23	150840935	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	11958703	150840935	4429625	847	2268										
GABRE	2564	broad.mit.edu	37	chrX	151123932	151123932	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	cagagcgcagaagcagaagaCgaagcagatggcgatataga	14	7	0	6			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:151123932C>T	ENST00000370325.1	-	8	1098	c.1045G>A	c.(1045-1047)Gtc>Atc	p.V349I	GABRE_ENST00000483564.1_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.V349I			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	349					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCAGAAGACGAAGCAGATG	0.488													57	60					0	0	1	0	0	T	151123932	C	T	151123932	3	4	21	1	0	0	0	0	1	0	0	0	6204	536	19	1	483	1	GABRE	23	151123932	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	282997	151123932	4146628	848	2269										
MAGEA12	4111	broad.mit.edu	37	chrX	151900216	151900216	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	aggaggcctgtcttgggcacGatctgattgtcgcccagcag	14	11	2	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:151900216G>A	ENST00000393900.3	-	3	938	c.585C>T	c.(583-585)atC>atT	p.I195I	MAGEA12_ENST00000393869.3_Silent_p.I195I|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Silent_p.I195I	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	195	MAGE.							p.I195I(1)		breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGGGCACGATCTGATTGT	0.577													99	136					0	0	1	0	0	A	151900216	G	A	151900216	2	1	21	1	0	0	0	0	0	0	0	1	9211	1048	37	1		1	MAGEA12	23	151900216	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	776284	151900216	3370344	849	2270										
CETN2	1069	broad.mit.edu	37	chrX	151997817	151997817	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caaagcccagggccctcattGccacctataaagaaaacagg	8	13	1	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:151997817G>A	ENST00000370277.3	-	3	233	c.167C>T	c.(166-168)gCa>gTa	p.A56V	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	56	EF-hand 1.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCCTCATTGCCACCTATAA	0.393								Direct reversal of damage;Nucleotide excision repair (NER)					15	41					0	0	1	0	0	A	151997817	G	A	151997817	3	1	21	1	0	0	0	0	1	0	0	0	3297	1319	46	3	363	3	CETN2	23	151997817	Missense_Mutation	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	97601	151997817	3272743	850	2271										
SLC6A8	6535	broad.mit.edu	37	chrX	152960290	152960290	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gccctgtcctccatgctgtgCgtgccgctgcacctcctggg	12	17	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:152960290C>T	ENST00000253122.5	+	12	2189	c.1713C>T	c.(1711-1713)tgC>tgT	p.C571C	SLC6A8_ENST00000430077.2_Silent_p.C456C|SLC6A8_ENST00000485324.1_3'UTR	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	571					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	CCATGCTGTGCGTGCCGCTGC	0.662													11	19					0	0	1	0	0	T	152960290	C	T	152960290	2	4	21	1	0	0	0	0	0	0	0	1	14744	776	27	1		1	SLC6A8	23	152960290	Silent	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	962473	152960290	2310270	851	2272										
L1CAM	3897	broad.mit.edu	37	chrX	153129471	153129471	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	gcaggagggagcctcacgcgGcctgagggtgagacaccagc	17	12	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153129471G>A	ENST00000370060.1	-	26	3513	c.3322_splice	c.e26-1	p.G1108_splice	L1CAM_ENST00000543994.1_Splice_Site_p.G1110_splice|L1CAM_ENST00000538883.1_Splice_Site_p.G1110_splice|L1CAM_ENST00000361699.4_Splice_Site_p.G1108_splice|L1CAM_ENST00000370055.1_Splice_Site_p.G1103_splice|L1CAM_ENST00000370057.3_Splice_Site_p.G1108_splice|L1CAM_ENST00000361981.3_Splice_Site_p.G1103_splice	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	1108	Fibronectin type-III 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCTCACGCGGCCTGAGGGTG	0.637													23	37					0	0	1	0	0	A	153129471	G	A	153129471	5	1	21	1	0	0	0	0	0	0	1	0	8626	1217	42	3	465	3	L1CAM	23	153129471	Splice_Site	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	169181	153129471	2141089	852	2273										
ARHGAP4	393	broad.mit.edu	37	chrX	153179298	153179298	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgggctctgggcagaatctcGtcccgcagctccatttcaac	10	14	3	1			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153179298G>A	ENST00000370028.3	-	9	1245	c.1188C>T	c.(1186-1188)gaC>gaT	p.D396D	ARHGAP4_ENST00000537206.1_Silent_p.D333D|ARHGAP4_ENST00000350060.5_Silent_p.D356D|ARHGAP4_ENST00000370016.1_Silent_p.D335D|ARHGAP4_ENST00000393721.1_Silent_p.D178D	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	356					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGAATCTCGTCCCGCAGCT	0.652													23	37					0	0	1	0	0	A	153179298	G	A	153179298	2	1	21	1	0	0	0	0	0	0	0	1	882	1136	40	1		1	ARHGAP4	23	153179298	Silent	SNP	G	TCGA-N7-A4Y0-01A-12D-A28R-08	49827	153179298	2091262	853	2274										
NAA10	8260	broad.mit.edu	37	chrX	153196294	153196294	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tagtatttgggctccacttcActgatcctgggggcagaggg	14	9	1	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153196294A>T	ENST00000464845.1	-	7	711	c.393T>A	c.(391-393)agT>agA	p.S131R	NAA10_ENST00000370009.1_Missense_Mutation_p.S116R|NAA10_ENST00000393712.3_Missense_Mutation_p.S131R|NAA10_ENST00000370015.4_Missense_Mutation_p.S131R	NM_001256120.1|NM_003491.3	NP_001243049.1|NP_003482.1	P41227	NAA10_HUMAN	N(alpha)-acetyltransferase 10, NatA catalytic subunit	131	N-acetyltransferase.				DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(3)|ovary(1)|prostate(1)	10						GCTCCACTTCACTGATCCTGG	0.587													64	98					0	0	1	0	0	T	153196294	A	T	153196294	3	4	21	1	0	0	0	0	1	0	0	0	10163	156	6	4	322	4	NAA10	23	153196294	Missense_Mutation	SNP	A	TCGA-N7-A4Y0-01A-12D-A28R-08	16996	153196294	2074266	854	2275										
FLNA	0	broad.mit.edu	37	chrX	153588429	153588429	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	caggttccacctgcagcttgCtggggaagttgggcacgggc	16	11	0	0			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153588429C>A	ENST00000422373.1	-	22	3982	c.3734G>T	c.(3733-3735)aGc>aTc	p.S1245I	FLNA_ENST00000369850.3_Missense_Mutation_p.S1245I|FLNA_ENST00000344736.4_Missense_Mutation_p.S1245I|FLNA_ENST00000360319.4_Missense_Mutation_p.S1245I	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1245					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCAGCTTGCTGGGGAAGTT	0.632													47	58					2.56175e-15	2.76001e-15	1	1	0	A	153588429	C	A	153588429	3	1	21	1	0	0	0	0	1	0	0	0	5965	797	28	5	4317	5	FLNA	23	153588429	Missense_Mutation	SNP	C	TCGA-N7-A4Y0-01A-12D-A28R-08	392135	153588429	1682131	855	2276										
G6PD	2539	broad.mit.edu	37	chrX	153762334	153762334	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0117096018735363	10	1	0.206252798633746	0	0.21360147316939	0.000296625880608082	0.00797173111520465	0	tgaggataacgcaggcgatgTtgtcccggttccagatgggg	16	8	0	2			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153762334T>C	ENST00000393562.2	-	7	1159	c.776A>G	c.(775-777)aAc>aGc	p.N259S	G6PD_ENST00000369620.2_Missense_Mutation_p.N229S|G6PD_ENST00000393564.2_Missense_Mutation_p.N229S	NM_000402.3	NP_000393.4	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase	229					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(3)|ovary(4)	18	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCAGGCGATGTTGTCCCGGTT	0.587													39	69					0	0	1	0	0	C	153762334	T	C	153762334	3	2	21	1	0	0	0	0	1	0	0	0	6180	1725	60	4	889	4	G6PD	23	153762334	Missense_Mutation	SNP	T	TCGA-N7-A4Y0-01A-12D-A28R-08	173905	153762334	1508226	856	2277										
CASZ1	54897	broad.mit.edu	37	chr1	10711029	10711029	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cacagtcaggtctagactgcGgtcctgggaggcttcgtggg	16	10	2	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:10711029G>A	ENST00000377022.3	-	12	3102	c.2785C>T	c.(2785-2787)Cgc>Tgc	p.R929C	CASZ1_ENST00000344008.5_Missense_Mutation_p.R929C|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	929					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TCTAGACTGCGGTCCTGGGAG	0.711													8	19					0	0	1	0	0	A	10711029	G	A	10711029	3	1	22	1	0	0	0	0	1	0	0	0	2703	1116	39	1	2538	1	CASZ1	1	10711029	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		10711029	238539592	1	2278										
PAX7	5081	broad.mit.edu	37	chr1	19018402	19018402	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tacccagacatatacacccgCgaggagctggcgcagaggac	12	13	0	2	rs148641282	by1000genomes	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:19018402C>T	ENST00000420770.2	+	5	824	c.741C>T	c.(739-741)cgC>cgT	p.R247R	PAX7_ENST00000375375.3_Silent_p.R247R|PAX7_ENST00000400661.3_Silent_p.R245R	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	247					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		TATACACCCGCGAGGAGCTGG	0.607			T	FOXO1A	alveolar rhabdomyosarcoma								13	20					0	0	1	0	0	T	19018402	C	T	19018402	2	4	22	1	0	0	0	0	0	0	0	1	11530	755	27	1		1	PAX7	1	19018402	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	8307373	19018402	230232219	2	2279										
KCNC4	3749	broad.mit.edu	37	chr1	110754451	110754451	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gcctacgtgctcaactactaCcgcaccggcaagctgcactg	9	16	1	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:110754451C>T	ENST00000369787.3	+	1	357	c.330C>T	c.(328-330)taC>taT	p.Y110Y	KCNC4_ENST00000438661.2_Silent_p.Y110Y|KCNC4_ENST00000413138.3_Silent_p.Y110Y	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	110					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TCAACTACTACCGCACCGGCA	0.677													23	26					0	0	1	0	0	T	110754451	C	T	110754451	2	4	22	1	0	0	0	0	0	0	0	1	8060	518	18	3		3	KCNC4	1	110754451	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	91736049	110754451	138496170	3	2280										
RC3H1	149041	broad.mit.edu	37	chr1	173907982	173907982	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	aggaggctgatattctcttgTgtcaaggctgatccatttgg	12	7	2	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:173907982T>C	ENST00000367696.2	-	20	3630	c.3279A>G	c.(3277-3279)acA>acG	p.T1093T	RC3H1_ENST00000367694.2_Silent_p.T1085T|RC3H1_ENST00000258349.4_Silent_p.T1093T			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	1093					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TATTCTCTTGTGTCAAGGCTG	0.413													17	19					0	0	1	0	0	C	173907982	T	C	173907982	2	2	22	1	0	0	0	0	0	0	0	1	13217	1683	59	4		4	RC3H1	1	173907982	Silent	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08	63153531	173907982	75342639	4	2281										
FAM5C	0	broad.mit.edu	37	chr1	190067523	190067523	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	agaggttcatagtaaatgctCtcattaccattgggaccatt	8	8	2	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:190067523C>T	ENST00000367462.3	-	8	2157	c.1926G>A	c.(1924-1926)gaG>gaA	p.E642E	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.E540E	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		642						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGTAAATGCTCTCATTACCAT	0.418													101	5					0	0	1	0	0	T	190067523	C	T	190067523	2	4	22	1	0	0	0	0	0	0	0	1	5628	912	32	3		3	FAM5C	1	190067523	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	16159541	190067523	59183098	5	2282										
OBSCN	84033	broad.mit.edu	37	chr1	228511259	228511259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gcgtctaccgctgcctggccGagaacagcatgggtgtctcc	13	14	2	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:228511259G>A	ENST00000570156.2	+	67	18549	c.18475G>A	c.(18475-18477)Gag>Aag	p.E6159K	OBSCN_ENST00000422127.1_Missense_Mutation_p.E5202K|OBSCN_ENST00000366707.4_Missense_Mutation_p.E2836K|OBSCN_ENST00000284548.11_Missense_Mutation_p.E5202K|OBSCN_ENST00000366709.4_Missense_Mutation_p.E2321K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5202	Ig-like 53.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGCCTGGCCGAGAACAGCAT	0.582													21	22					0	0	1	0	0	A	228511259	G	A	228511259	3	1	22	1	0	0	0	0	1	0	0	0	10859	1059	37	1	15822	1	OBSCN	1	228511259	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	38443736	228511259	20739362	6	2283										
SLC8A1	6546	broad.mit.edu	37	chr2	40342516	40342516	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggcccacccagctcacctccGatttctggcctccgccgata	8	19	2	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:40342516G>A	ENST00000406785.1	-	8	2880	c.2691C>T	c.(2689-2691)atC>atT	p.I897I	SLC8A1_ENST00000403092.1_Silent_p.I933I|SLC8A1_ENST00000402441.1_Silent_p.I897I|SLC8A1_ENST00000408028.2_Silent_p.I925I|SLC8A1_ENST00000406391.2_Silent_p.I897I|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000405901.3_Silent_p.I928I|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1_ENST00000405269.1_Silent_p.I897I|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000332839.4_Silent_p.I933I|SLC8A1_ENST00000542756.1_Silent_p.I928I|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1_ENST00000542024.1_Silent_p.I897I|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	933					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTCACCTCCGATTTCTGGCC	0.547													21	49					0	0	1	0	0	A	40342516	G	A	40342516	2	1	22	1	0	0	0	0	0	0	0	1	14760	1048	37	1		1	SLC8A1	2	40342516	Silent	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		40342516	202856857	7	2284										
POLR1A	25885	broad.mit.edu	37	chr2	86302260	86302260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gctcagggctgtgcggctgcCgtcctcattgatgaccatgg	14	12	2	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:86302260C>T	ENST00000263857.6	-	12	1882	c.1504G>A	c.(1504-1506)Ggc>Agc	p.G502S	POLR1A_ENST00000409681.1_Missense_Mutation_p.G502S			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	502					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GTGCGGCTGCCGTCCTCATTG	0.627													12	7					0	0	1	0	0	T	86302260	C	T	86302260	3	4	22	1	0	0	0	0	1	0	0	0	12256	652	23	1	3750	1	POLR1A	2	86302260	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	45959744	86302260	156897113	8	2285										
TMEM131	23505	broad.mit.edu	37	chr2	98429149	98429149	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	aaataaaatattacttgcttCtgtagcactcagtactccaa	4	9	2	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:98429149C>G	ENST00000186436.5	-	16	1909	c.1681G>C	c.(1681-1683)Gaa>Caa	p.E561Q		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	561						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TTACTTGCTTCTGTAGCACTC	0.308													10	18					0	0	1	0	0	G	98429149	C	G	98429149	3	3	22	1	0	0	0	0	1	0	0	0	16103	922	32	2	4074	2	TMEM131	2	98429149	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	12126889	98429149	144770224	9	2286										
CHST10	9486	broad.mit.edu	37	chr2	101011979	101011979	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	agctgttctcaccgcttctgAatttctgcatcactgaagga	8	11	4	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:101011979A>G	ENST00000264249.3	-	6	910	c.525T>C	c.(523-525)atT>atC	p.I175I	CHST10_ENST00000542617.1_Silent_p.I223I|CHST10_ENST00000409701.1_Silent_p.I175I	NM_004854.4	NP_004845.1	O43529	CHSTA_HUMAN	carbohydrate sulfotransferase 10	175					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						ACCGCTTCTGAATTTCTGCAT	0.507													18	35					0	0	1	0	0	G	101011979	A	G	101011979	2	3	22	1	0	0	0	0	0	0	0	1	3420	242	9	4		4	CHST10	2	101011979	Silent	SNP	A	TCGA-N7-A4Y5-01A-12D-A28R-08	2582830	101011979	142187394	10	2287										
MYO7B	4648	broad.mit.edu	37	chr2	128350403	128350403	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gctgtgcctgcggcagctgcGatactcgggcatgatggaga	16	10	0	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:128350403G>A	ENST00000389524.4	+	17	2080	c.2027G>A	c.(2026-2028)cGa>cAa	p.R676Q	MYO7B_ENST00000409816.2_Missense_Mutation_p.R676Q|MYO7B_ENST00000428314.1_Missense_Mutation_p.R676Q			Q6PIF6	MYO7B_HUMAN	myosin VIIB	676	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGGCAGCTGCGATACTCGGGC	0.667													5	14					0	0	1	0	0	A	128350403	G	A	128350403	3	1	22	1	0	0	0	0	1	0	0	0	10130	1058	37	1	2089	1	MYO7B	2	128350403	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	27338424	128350403	114848970	11	2288										
MGAT5	4249	broad.mit.edu	37	chr2	135012115	135012115	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gaaagcagctccatgctgcgCgagcagatcctggacctcag	12	13	1	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:135012115C>T	ENST00000409645.1	+	2	393	c.141C>T	c.(139-141)cgC>cgT	p.R47R	MGAT5_ENST00000468758.1_3'UTR|MGAT5_ENST00000281923.2_Silent_p.R47R			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	47					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CCATGCTGCGCGAGCAGATCC	0.512													19	39					0	0	1	0	0	T	135012115	C	T	135012115	2	4	22	1	0	0	0	0	0	0	0	1	9597	755	27	1		1	MGAT5	2	135012115	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	6661712	135012115	108187258	12	2289										
ITGA6	0	broad.mit.edu	37	chr2	173355990	173355990	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgtgtgaacatcagatgcccGctgcgggggctggacagcaa	15	10	1	2	rs34599583	byFrequency	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:173355990G>A	ENST00000375221.2	+	23	3140	c.2937G>A	c.(2935-2937)ccG>ccA	p.P979P	AC093818.1_ENST00000442417.1_RNA|ITGA6_ENST00000264106.6_Silent_p.P979P|ITGA6_ENST00000409532.1_Silent_p.P821P|ITGA6_ENST00000409080.1_Silent_p.P940P|ITGA6_ENST00000264107.7_Silent_p.P940P|ITGA6_ENST00000343713.4_Silent_p.P935P			P23229	ITA6_HUMAN	integrin, alpha 6	979					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TCAGATGCCCGCTGCGGGGGC	0.483													44	100					0	0	1	0	0	A	173355990	G	A	173355990	2	1	22	1	0	0	0	0	0	0	0	1	7923	1074	38	1		1	ITGA6	2	173355990	Silent	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	38343875	173355990	69843383	13	2290										
MYO1B	4430	broad.mit.edu	37	chr2	192227005	192227005	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	attcaatagataaacttaagCttgagagggatttcagcagg	10	5	2	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:192227005C>G	ENST00000392318.3	+	9	920	c.673C>G	c.(673-675)Ctt>Gtt	p.L225V	MYO1B_ENST00000339514.4_Missense_Mutation_p.L225V|MYO1B_ENST00000392316.1_Missense_Mutation_p.L225V|MYO1B_ENST00000304164.4_Missense_Mutation_p.L225V	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	225	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TAAACTTAAGCTTGAGAGGGA	0.383													19	25					0	0	1	0	0	G	192227005	C	G	192227005	3	3	22	1	0	0	0	0	1	0	0	0	10116	797	28	5	703	5	MYO1B	2	192227005	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	18871015	192227005	50972368	14	2291										
ABCA12	26154	broad.mit.edu	37	chr2	215876784	215876784	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgtgccagaagccatctgatTgagaatctcttttagtctta	8	8	3	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:215876784T>G	ENST00000272895.7	-	16	2251	c.2032A>C	c.(2032-2034)Aat>Cat	p.N678H	ABCA12_ENST00000389661.4_Missense_Mutation_p.N360H	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	678					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GCCATCTGATTGAGAATCTCT	0.403													28	79					0	0	1	0	0	G	215876784	T	G	215876784	3	3	22	1	0	0	0	0	1	0	0	0	30	1812	63	4	5907	4	ABCA12	2	215876784	Missense_Mutation	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08	23649779	215876784	27322589	15	2292										
ECEL1	9427	broad.mit.edu	37	chr2	233346218	233346218	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggcaggtgggggtctcacccGctggttgtagacagtgaagt	17	8	1	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:233346218G>A	ENST00000304546.1	-	14	2197	c.1987C>T	c.(1987-1989)Cgg>Tgg	p.R663W	ECEL1_ENST00000409941.1_Missense_Mutation_p.R661W	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	663					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGTCTCACCCGCTGGTTGTAG	0.622													10	15					0	0	1	0	0	A	233346218	G	A	233346218	3	1	22	1	0	0	0	0	1	0	0	0	4917	1086	38	1	360	1	ECEL1	2	233346218	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	17469434	233346218	9853155	16	2293										
LRRFIP1	9208	broad.mit.edu	37	chr2	238643971	238643971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggggcagcacctccggctccCgtgctgtaaggcgctttcgg	15	14	0	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:238643971C>G	ENST00000308482.9	+	10	619	c.550C>G	c.(550-552)Cgt>Ggt	p.R184G	LRRFIP1_ENST00000392000.4_Intron|LRRFIP1_ENST00000244815.5_Intron|LRRFIP1_ENST00000289175.6_Intron	NM_001137550.1	NP_001131022.1	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	55					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		CTCCGGCTCCCGTGCTGTAAG	0.652													5	19					0	0	1	0	0	G	238643971	C	G	238643971	3	3	22	1	0	0	0	0	1	0	0	0	9071	652	23	5	658	5	LRRFIP1	2	238643971	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	5297753	238643971	4555402	17	2294										
UQCRC1	7384	broad.mit.edu	37	chr3	48646687	48646687	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cggcacgaactggagcgcctGagcgaaggttgccgtactcc	14	13	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:48646687G>C	ENST00000203407.5	-	2	534	c.118C>G	c.(118-120)Cag>Gag	p.Q40E		NM_003365.2	NP_003356.2	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	40					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	TGGAGCGCCTGAGCGAAGGTT	0.667													35	1					0	0	1	0	0	C	48646687	G	C	48646687	3	2	22	1	0	0	0	0	1	0	0	0	17078	1299	45	2	1372	2	UQCRC1	3	48646687	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		48646687	149375743	18	2295										
CELSR3	1951	broad.mit.edu	37	chr3	48681080	48681081	+	Frame_Shift_Del	DEL	CA	CA	-													0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	agccaggaggcactgaccagCagaagcagcaggaaggagct							TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:48681080_48681081delCA	ENST00000544264.1	-	29	8490_8491	c.8210_8211delTG	c.(8209-8211)cfs	p.L2738fs	CELSR3_ENST00000164024.4_Frame_Shift_Del_p.L2733fs			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2733					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CACTGACCAGCAGAAGCAGCAG	0.599													2	4	---	---	---	---						-	48681081	CA	-	48681080	7	5	22	1	0	1	0	1	0	0	0	0	3245	697	25	0	1774	0	CELSR3	3	48681080	Frame_Shift_Del	DEL	CA	TCGA-N7-A4Y5-01A-12D-A28R-08	34393	48681080	149341350	19	2296										
PIK3CA	5290	broad.mit.edu	37	chr3	178936095	178936095	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tctctctgaaatcactgagcAggagaaagattttctatgga	9	7	4	4			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:178936095A>G	ENST00000263967.3	+	10	1794	c.1637A>G	c.(1636-1638)cAg>cGg	p.Q546R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	546	PI3K helical.		Q -> E (in cancer).|Q -> K (in cancer).|Q -> P (in cancer).|Q -> R (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Q546R(30)|p.Q546P(18)|p.Q546L(5)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCACTGAGCAGGAGAAAGAT	0.363		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			32	18					0	0	1	0	0	G	178936095	A	G	178936095	3	3	22	1	0	0	0	0	1	0	0	0	11960	188	7	4	1671	4	PIK3CA	3	178936095	Missense_Mutation	SNP	A	TCGA-N7-A4Y5-01A-12D-A28R-08	130255015	178936095	19086335	20	2297										
ATP11B	23200	broad.mit.edu	37	chr3	182597349	182597349	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gaccagcctatctcttgcacTcagggagcatgaaaaactat	8	11	2	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:182597349T>G	ENST00000323116.5	+	20	2578	c.2318T>G	c.(2317-2319)cTc>cGc	p.L773R		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	773					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TCTCTTGCACTCAGGGAGCAT	0.378													45	24					0	0	1	0	0	G	182597349	T	G	182597349	3	3	22	1	0	0	0	0	1	0	0	0	1119	1551	54	4	2396	4	ATP11B	3	182597349	Missense_Mutation	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08	3661254	182597349	15425081	21	2298										
SH3TC1	54436	broad.mit.edu	37	chr4	8229382	8229382	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cctgcagctggcgctgcggcGggcggtgggtggccagagcc	20	13	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:8229382G>C	ENST00000539824.1	+	12	2107	c.1733G>C	c.(1732-1734)cGg>cCg	p.R578P	SH3TC1_ENST00000245105.3_Missense_Mutation_p.R654P			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	654							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GCGCTGCGGCGGGCGGTGGGT	0.726													19	15					0	0	1	0	0	C	8229382	G	C	8229382	3	2	22	1	0	0	0	0	1	0	0	0	14315	1116	39	5	2003	5	SH3TC1	4	8229382	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		8229382	182924894	22	2299										
PRSS12	8492	broad.mit.edu	37	chr4	119237434	119237434	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tctgtaatatacctccaagcGaccctcatggctgcctttcc	6	15	2	0	rs139059047		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:119237434G>C	ENST00000296498.3	-	6	1477	c.1195C>G	c.(1195-1197)Cgc>Ggc	p.R399G		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	399	SRCR 3.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						ACCTCCAAGCGACCCTCATGG	0.458													14	23					0	0	1	0	0	C	119237434	G	C	119237434	3	2	22	1	0	0	0	0	1	0	0	0	12664	1058	37	2	1464	2	PRSS12	4	119237434	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	111008052	119237434	71916842	23	2300										
SPATA5	166378	broad.mit.edu	37	chr4	123855466	123855466	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cagctaagccagttagatctGgaggatacccagatcccaac	9	12	1	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:123855466G>T	ENST00000274008.3	+	5	789	c.720G>T	c.(718-720)ctG>ctT	p.L240L	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	240					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						AGTTAGATCTGGAGGATACCC	0.428													23	29					1.50039e-11	1.60507e-11	1	1	0	T	123855466	G	T	123855466	2	4	22	1	0	0	0	0	0	0	0	1	15066	1335	47	5		5	SPATA5	4	123855466	Silent	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	4618032	123855466	67298810	24	2301										
NPR3	4883	broad.mit.edu	37	chr5	32712485	32712485	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	caccactggagccgcgctgcActggtctacagcgacgacaa	11	15	1	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:32712485A>C	ENST00000265074.8	+	1	946	c.603A>C	c.(601-603)gcA>gcC	p.A201A	NPR3_ENST00000434067.2_Intron|NPR3_ENST00000415167.2_Silent_p.A201A|NPR3_ENST00000415685.2_Intron	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	201					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	GCCGCGCTGCACTGGTCTACA	0.632													26	133					0	0	1	0	0	C	32712485	A	C	32712485	2	2	22	1	0	0	0	0	0	0	0	1	10643	146	6	4		4	NPR3	5	32712485	Silent	SNP	A	TCGA-N7-A4Y5-01A-12D-A28R-08		32712485	148202775	25	2302										
FGF10	2255	broad.mit.edu	37	chr5	44305205	44305205	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	aatgccacatacatttgcctCccattatgctgccagttaaa	5	12	0	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:44305205C>A	ENST00000264664.4	-	3	633	c.519G>T	c.(517-519)ggG>ggT	p.G173G		NM_004465.1	NP_004456.1	O15520	FGF10_HUMAN	fibroblast growth factor 10	173					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					ACATTTGCCTCCCATTATGCT	0.413													30	129					4.40665e-25	4.76955e-25	1	1	0	A	44305205	C	A	44305205	2	1	22	1	0	0	0	0	0	0	0	1	5871	842	30	2		2	FGF10	5	44305205	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	11592720	44305205	136610055	26	2303										
PDE4D	5144	broad.mit.edu	37	chr5	58289244	58289244	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgacacttgatttccagaccGactcatttcagagagatggg	10	9	2	5			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:58289244G>C	ENST00000340635.6	-	7	1145	c.970C>G	c.(970-972)Cgg>Ggg	p.R324G	PDE4D_ENST00000503258.1_Missense_Mutation_p.R194G|PDE4D_ENST00000507116.1_Missense_Mutation_p.R260G|PDE4D_ENST00000360047.5_Missense_Mutation_p.R188G|PDE4D_ENST00000317118.8_Missense_Mutation_p.R33G|PDE4D_ENST00000502484.2_Missense_Mutation_p.R263G|PDE4D_ENST00000546160.1_Missense_Mutation_p.R263G|PDE4D_ENST00000405755.2_Missense_Mutation_p.R202G|PDE4D_ENST00000358923.6_Missense_Mutation_p.R22G	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	324					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TTTCCAGACCGACTCATTTCA	0.318													10	16					0	0	1	0	0	C	58289244	G	C	58289244	3	2	22	1	0	0	0	0	1	0	0	0	11688	1057	37	2	1495	2	PDE4D	5	58289244	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	13984039	58289244	122626016	27	2304										
FBN2	2201	broad.mit.edu	37	chr5	127670459	127670459	+	Frame_Shift_Del	DEL	G	G	-													0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgagtaacccagctgacagtGgcaaatgaaggatccctttg							TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:127670459delG	ENST00000508053.1	-	37	5025	c.4051delC	c.(4051-4053)acfs	p.H1351fs	FBN2_ENST00000507835.1_Frame_Shift_Del_p.H201fs|FBN2_ENST00000508989.1_Frame_Shift_Del_p.H1318fs|FBN2_ENST00000262464.4_Frame_Shift_Del_p.H1351fs			P35556	FBN2_HUMAN	fibrillin 2	1351	EGF-like 21; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGCTGACAGTGGCAAATGAAG	0.398													26	32	---	---	---	---						-	127670459	G	-	127670459	7	5	22	1	0	1	0	1	0	0	0	0	5735	1348	47	0	4827	0	FBN2	5	127670459	Frame_Shift_Del	DEL	G	TCGA-N7-A4Y5-01A-12D-A28R-08	69381215	127670459	53244801	28	2305										
PCDHA2	0	broad.mit.edu	37	chr5	140174613	140174613	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgctctcgcttctgctcctcGcagcctgggaggtggggagc	15	13	2	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:140174613G>A	ENST00000526136.1	+	1	64	c.64G>A	c.(64-66)Gca>Aca	p.A22T	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.A22T|PCDHA2_ENST00000378132.1_Missense_Mutation_p.A22T	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGCTCCTCGCAGCCTGGGA	0.622													30	30					0	0	1	0	0	A	140174613	G	A	140174613	3	1	22	1	0	0	0	0	1	0	0	0	11570	1087	38	1	66	1	PCDHA2	5	140174613	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	12504154	140174613	40740647	29	2306										
PCDHB6	0	broad.mit.edu	37	chr5	140531787	140531787	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggacaatggcgagcctccgcGctcggccaccgccacgctgc	13	18	0	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:140531787G>C	ENST00000231136.1	+	1	1949	c.1949G>C	c.(1948-1950)cGc>cCc	p.R650P	PCDHB6_ENST00000543635.1_Missense_Mutation_p.R514P	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		650	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCCTCCGCGCTCGGCCACC	0.701													43	40					0	0	1	0	0	C	140531787	G	C	140531787	3	2	22	1	0	0	0	0	1	0	0	0	11592	1087	38	5	1951	5	PCDHB6	5	140531787	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	357174	140531787	40383473	30	2307										
HIST1H2BJ	8970	broad.mit.edu	37	chr6	27100294	27100295	+	Frame_Shift_Ins	INS	-	-	T													0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gttgtaatgcgccaggcgggINSaagcctcacctgcgatgcgc							TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr6:27100294_27100295insT	ENST00000607124.1	-	1	234_235	c.235_236insA	c.(235-237)ccgfs	p.P79fs	HIST1H2BJ_ENST00000541790.1_Frame_Shift_Ins_p.P79fs|HIST1H2BJ_ENST00000339812.2_Frame_Shift_Ins_p.P79fs			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	79					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						CGCCAGGCGGGAAGCCTCACCT	0.604													118	76	---	---	---	---						T	27100295	-	T	27100294	7	5	22	1	0	1	1	0	0	0	0	0	7189	1174	41	0	148	0	HIST1H2BJ	6	27100294	Frame_Shift_Ins	INS	-	TCGA-N7-A4Y5-01A-12D-A28R-08		27100294	144014773	31	2308										
OPRM1	4988	broad.mit.edu	37	chr6	154360937	154360937	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gtgtgcgtggtggggctcttCggaaacttcctggtcatgta	15	8	2	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr6:154360937C>T	ENST00000414028.2	+	1	308	c.258C>T	c.(256-258)ttC>ttT	p.F86F	OPRM1_ENST00000337049.4_Silent_p.F86F|OPRM1_ENST00000523520.1_3'UTR|OPRM1_ENST00000419506.2_Silent_p.F86F|OPRM1_ENST00000435918.2_Silent_p.F86F|OPRM1_ENST00000360422.4_Silent_p.F86F|OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000330432.7_Silent_p.F86F|OPRM1_ENST00000434900.2_Silent_p.F179F|OPRM1_ENST00000524163.1_Silent_p.F86F|OPRM1_ENST00000452687.2_Silent_p.F86F|OPRM1_ENST00000428397.2_Silent_p.F86F|OPRM1_ENST00000229768.5_Silent_p.F86F|OPRM1_ENST00000518759.1_Intron	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	86					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TGGGGCTCTTCGGAAACTTCC	0.592													21	52					0	0	1	0	0	T	154360937	C	T	154360937	2	4	22	1	0	0	0	0	0	0	0	1	10934	883	31	1		1	OPRM1	6	154360937	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	127260643	154360937	16754130	32	2309										
DNAH11	8701	broad.mit.edu	37	chr7	21789392	21789392	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ttctagatgagagcttcctcGtgctgattaatgacttgctg	10	8	1	4	rs72657369		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:21789392G>A	ENST00000328843.6	+	54	8822	c.8791G>A	c.(8791-8793)Gtg>Atg	p.V2931M	DNAH11_ENST00000409508.3_Missense_Mutation_p.V2924M			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2931	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GAGCTTCCTCGTGCTGATTAA	0.428									Kartagener syndrome				21	17					0	0	1	0	0	A	21789392	G	A	21789392	3	1	22	1	0	0	0	0	1	0	0	0	4627	1145	40	1	9002	1	DNAH11	7	21789392	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		21789392	137349271	33	2310										
ZNF107	51427	broad.mit.edu	37	chr7	64167232	64167232	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggcataagataattcatactGaagagaaacccaacaaatgt	7	7	1	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:64167232G>A	ENST00000395391.1	+	4	1925	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	ZNF107_ENST00000344930.3_Missense_Mutation_p.E184K|ZNF107_ENST00000423627.1_Missense_Mutation_p.E184K			Q9UII5	ZN107_HUMAN	zinc finger protein 107	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AATTCATACTGAAGAGAAACC	0.368													11	21					0	0	1	0	0	A	64167232	G	A	64167232	3	1	22	1	0	0	0	0	1	0	0	0	17772	1291	45	3	556	3	ZNF107	7	64167232	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	42377840	64167232	94971431	34	2311										
STEAP4	79689	broad.mit.edu	37	chr7	87912423	87912423	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	atccattggagtaagtccaaGattacgaacaatatccatca	6	9	1	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:87912423G>A	ENST00000380079.4	-	3	618	c.517C>T	c.(517-519)Ctt>Ttt	p.L173F	AC003991.3_ENST00000595121.1_RNA|STEAP4_ENST00000301959.5_Intron|AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000447758.1_RNA|STEAP4_ENST00000414498.1_Missense_Mutation_p.L173F|AC003991.3_ENST00000434733.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	173					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					GTAAGTCCAAGATTACGAACA	0.388													18	20					0	0	1	0	0	A	87912423	G	A	87912423	3	1	22	1	0	0	0	0	1	0	0	0	15335	942	33	3	874	3	STEAP4	7	87912423	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	23745191	87912423	71226240	35	2312										
EPHB6	0	broad.mit.edu	37	chr7	142562260	142562260	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ttctcctacacctgccctgcCgtgctccgatcctttgcttc	6	18	1	0	rs148221019		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:142562260C>A	ENST00000392957.2	+	7	1489	c.702C>A	c.(700-702)gcC>gcA	p.A234A	EPHB6_ENST00000442129.1_Silent_p.A234A|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	234	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CCTGCCCTGCCGTGCTCCGAT	0.667													41	78					9.73076e-26	1.06575e-25	1	1	0	A	142562260	C	A	142562260	2	1	22	1	0	0	0	0	0	0	0	1	5206	639	23	5		5	EPHB6	7	142562260	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	54649837	142562260	16576403	36	2313										
XKR4	114786	broad.mit.edu	37	chr8	56270402	56270402	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gctggtcctgcagctctgcaTtatcgtacagactcatagct	9	12	2	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:56270402T>G	ENST00000327381.5	+	2	1071	c.971T>G	c.(970-972)aTt>aGt	p.I324S		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	324						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCTCTGCATTATCGTACAG	0.453													12	76					0	0	1	0	0	G	56270402	T	G	56270402	3	3	22	1	0	0	0	0	1	0	0	0	17492	1493	52	4	977	4	XKR4	8	56270402	Missense_Mutation	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08		56270402	90093620	37	2314										
GPR20	2843	broad.mit.edu	37	chr8	142367311	142367311	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgagcaggagctgcatggccCgcacgcggcgctggcgaccc	16	15	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:142367311C>T	ENST00000377741.3	-	2	803	c.713G>A	c.(712-714)cGg>cAg	p.R238Q		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	238						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CTGCATGGCCCGCACGCGGCG	0.667													3	23					0	0	1	0	0	T	142367311	C	T	142367311	3	4	22	1	0	0	0	0	1	0	0	0	6719	652	23	1	367	1	GPR20	8	142367311	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	86096909	142367311	3996711	38	2315										
EPPK1	83481	broad.mit.edu	37	chr8	144940592	144940592	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ccaccgacagcctcaggttgCgcacggggtcgatgacgaag	14	13	1	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:144940592C>T	ENST00000525985.1	-	2	6901	c.6830G>A	c.(6829-6831)cGc>cAc	p.R2277H				P58107	EPIPL_HUMAN	epiplakin 1	2277						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTCAGGTTGCGCACGGGGTC	0.726													13	263					0	0	1	0	0	T	144940592	C	T	144940592	3	4	22	1	0	0	0	0	1	0	0	0	5218	768	27	1	436	1	EPPK1	8	144940592	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	2573281	144940592	1423430	39	2316										
MFSD3	113655	broad.mit.edu	37	chr8	145735980	145735980	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	catttcccacccccatcccaGgaaactgctgcctctgttga	6	17	1	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:145735980G>A	ENST00000301327.4	+	3	1090		c.e3-1			NM_138431.1	NP_612440.1	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing 3						transmembrane transport	integral to membrane				central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCCCATCCCAGGAAACTGCTG	0.637													164	158					0	0	1	0	0	A	145735980	G	A	145735980	5	1	22	1	0	0	0	0	0	0	1	0	9581	1014	35	3	840	3	MFSD3	8	145735980	Splice_Site	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	795388	145735980	628042	40	2317										
ANGPTL2	23452	broad.mit.edu	37	chr9	129853995	129853995	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	agggtggtgaactgcttgccGttgtgccatgtaaaggagtc	15	7	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr9:129853995G>A	ENST00000373425.3	-	4	1853	c.1236C>T	c.(1234-1236)aaC>aaT	p.N412N	RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000373436.1_Intron|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000373434.1_Intron|ANGPTL2_ENST00000373417.1_Silent_p.N110N	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	412	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						ACTGCTTGCCGTTGTGCCATG	0.537													99	94					0	0	1	0	0	A	129853995	G	A	129853995	2	1	22	1	0	0	0	0	0	0	0	1	610	1136	40	1		1	ANGPTL2	9	129853995	Silent	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		129853995	11359436	41	2318										
OR51A7	119687	broad.mit.edu	37	chr11	4929145	4929145	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cactcatactgtcttcatcaGgataccatgaagctggcctg	8	12	4	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:4929145G>C	ENST00000359350.4	+	1	546	c.546G>C	c.(544-546)caG>caC	p.Q182H	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTCTTCATCAGGATACCATGA	0.403													21	41					0	0	1	0	0	C	4929145	G	C	4929145	3	2	22	1	0	0	0	0	1	0	0	0	11135	991	35	5	548	5	OR51A7	11	4929145	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		4929145	130077371	42	2319										
OR9Q2	219957	broad.mit.edu	37	chr11	57958846	57958846	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tatctatagcctgagaaacaAggaggtaaaagaggccacta	10	7	1	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:57958846A>G	ENST00000311591.3	+	1	941	c.884A>G	c.(883-885)aAg>aGg	p.K295R		NM_001005283.2	NP_001005283.1	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q, member 2	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(24)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41		Breast(21;0.0589)				CTGAGAAACAAGGAGGTAAAA	0.498													32	49					0	0	1	0	0	G	57958846	A	G	57958846	3	3	22	1	0	0	0	0	1	0	0	0	11302	72	3	4	886	4	OR9Q2	11	57958846	Missense_Mutation	SNP	A	TCGA-N7-A4Y5-01A-12D-A28R-08	53029701	57958846	77047670	43	2320										
NRXN2	9379	broad.mit.edu	37	chr11	64453157	64453157	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	acccggacgtcgtgccaggcGttgtcgttgaacttgccatt	12	12	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:64453157G>A	ENST00000265459.6	-	6	1574	c.1113C>T	c.(1111-1113)aaC>aaT	p.N371N	NRXN2_ENST00000377551.1_Silent_p.N371N|NRXN2_ENST00000377559.3_Silent_p.N347N|NRXN2_ENST00000409571.1_Silent_p.N371N	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	371	Laminin G-like 2.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CGTGCCAGGCGTTGTCGTTGA	0.592													62	65					0	0	1	0	0	A	64453157	G	A	64453157	2	1	22	1	0	0	0	0	0	0	0	1	10713	1136	40	1		1	NRXN2	11	64453157	Silent	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	6494311	64453157	70553359	44	2321										
MOGAT2	80168	broad.mit.edu	37	chr11	75439191	75439191	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggctcgccctgacacacgggTatcaagcctctgggaagagc	13	13	2	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:75439191T>C	ENST00000526712.1	+	3	1177		c.e3+2		MOGAT2_ENST00000198801.5_Splice_Site			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2						glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					GACACACGGGTATCAAGCCTC	0.547													15	3					0	0	1	0	0	C	75439191	T	C	75439191	5	2	22	1	0	0	0	0	0	0	1	0	9743	1652	57	4	666	4	MOGAT2	11	75439191	Splice_Site	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08	10986034	75439191	59567325	45	2322										
CRTAM	56253	broad.mit.edu	37	chr11	122726442	122726442	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgaaactgatgggaagaaatGtaatactaccagcactctca	8	8	1	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:122726442G>A	ENST00000227348.4	+	5	577	c.530G>A	c.(529-531)tGt>tAt	p.C177Y		NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	177	Ig-like C2-type.				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GGGAAGAAATGTAATACTACC	0.413													16	25					0	0	1	0	0	A	122726442	G	A	122726442	3	1	22	1	0	0	0	0	1	0	0	0	3920	1377	48	3	548	3	CRTAM	11	122726442	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	47287251	122726442	12280074	46	2323										
VWA5A	4013	broad.mit.edu	37	chr11	124006949	124006949	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tccccagaacagactgtcatCtttaggggtcagagattaat	9	9	3	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:124006949C>G	ENST00000456829.2	+	13	1724	c.1473C>G	c.(1471-1473)atC>atG	p.I491M	VWA5A_ENST00000392748.1_Missense_Mutation_p.I491M|VWA5A_ENST00000360334.4_Intron	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	491								p.I491I(1)		autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						AGACTGTCATCTTTAGGGGTC	0.493													26	39					0	0	1	0	0	G	124006949	C	G	124006949	3	3	22	1	0	0	0	0	1	0	0	0	17301	903	32	2	1519	2	VWA5A	11	124006949	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	1280507	124006949	10999567	47	2324										
KIF5A	3798	broad.mit.edu	37	chr12	57972082	57972082	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ccaaaagcagaagatttcctTtcttgagaacaacctggaac	7	10	1	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr12:57972082T>G	ENST00000455537.2	+	23	2769	c.2495T>G	c.(2494-2496)tTt>tGt	p.F832C	KIF5A_ENST00000286452.5_Missense_Mutation_p.F743C	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	832					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						AAGATTTCCTTTCTTGAGAAC	0.478													41	113					0	0	1	0	0	G	57972082	T	G	57972082	3	3	22	1	0	0	0	0	1	0	0	0	8346	1841	64	4	2585	4	KIF5A	12	57972082	Missense_Mutation	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08		57972082	75879813	48	2325										
KIAA1033	23325	broad.mit.edu	37	chr12	105543428	105543428	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cagtttttgaaaaagaagttCtatatatttagccaatttat	5	4	1	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr12:105543428C>T	ENST00000332180.5	+	25	2637	c.2550C>T	c.(2548-2550)ttC>ttT	p.F850F		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	850					endosome transport	WASH complex		p.F850L(1)		breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						AAAAGAAGTTCTATATATTTA	0.234													21	24					0	0	1	0	0	T	105543428	C	T	105543428	2	4	22	1	0	0	0	0	0	0	0	1	8247	912	32	3		3	KIAA1033	12	105543428	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	47571346	105543428	28308467	49	2326										
SACS	26278	broad.mit.edu	37	chr13	23908318	23908318	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tgcaaaattgtctttccactTtgtgcaacttttggtcttat	6	8	2	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr13:23908318T>C	ENST00000382298.3	-	10	10285	c.9697A>G	c.(9697-9699)Aag>Gag	p.K3233E	SACS_ENST00000382292.3_Missense_Mutation_p.K3233E|SACS_ENST00000402364.1_Missense_Mutation_p.K2483E	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3233					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCTTTCCACTTTGTGCAACTT	0.358													22	40					0	0	1	0	0	C	23908318	T	C	23908318	3	2	22	1	0	0	0	0	1	0	0	0	13855	1850	64	4	4046	4	SACS	13	23908318	Missense_Mutation	SNP	T	TCGA-N7-A4Y5-01A-12D-A28R-08		23908318	91261560	50	2327										
B3GALTL	145173	broad.mit.edu	37	chr13	31835102	31835102	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ggaatggtttttgggaaaagCattacatgatgaagaagcta	12	3	0	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr13:31835102C>T	ENST00000343307.4	+	7	628	c.479C>T	c.(478-480)gCa>gTa	p.A160V	B3GALTL_ENST00000461652.2_3'UTR	NM_194318.3	NP_919299.3	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	160					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		TTGGGAAAAGCATTACATGAT	0.348													7	8					0	0	1	0	0	T	31835102	C	T	31835102	3	4	22	1	0	0	0	0	1	0	0	0	1250	710	25	3	505	3	B3GALTL	13	31835102	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	7926784	31835102	83334776	51	2328										
OR4K2	390431	broad.mit.edu	37	chr14	20344949	20344949	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tctgtggtccctatgaggtaGacagctttttctgtgacctt	10	9	2	3			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr14:20344949G>T	ENST00000298642.2	+	1	559	c.523G>T	c.(523-525)Gac>Tac	p.D175Y		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTATGAGGTAGACAGCTTTTT	0.458													124	229					1.77382e-44	1.96616e-44	1	1	0	T	20344949	G	T	20344949	3	4	22	1	0	0	0	0	1	0	0	0	11119	942	33	2	525	2	OR4K2	14	20344949	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		20344949	87004591	52	2329										
LRP10	26020	broad.mit.edu	37	chr14	23345059	23345059	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	tggtcgtggcttcaatgccaCctaccatgtgcggggctatt	12	11	1	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr14:23345059C>G	ENST00000359591.4	+	5	1593	c.902C>G	c.(901-903)aCc>aGc	p.T301S	LRP10_ENST00000546834.1_Missense_Mutation_p.T301S	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	301	CUB 2.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TTCAATGCCACCTACCATGTG	0.582													24	39					0	0	1	0	0	G	23345059	C	G	23345059	3	3	22	1	0	0	0	0	1	0	0	0	8996	507	18	5	920	5	LRP10	14	23345059	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	3000110	23345059	84004481	53	2330										
OR2C1	4993	broad.mit.edu	37	chr16	3406726	3406726	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	agctatgggtatctgcttccGgccaagaacagcaaacagga	11	10	1	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr16:3406726G>A	ENST00000304936.2	+	1	838	c.786G>A	c.(784-786)ccG>ccA	p.P262P		NM_012368.2	NP_036500.2	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C, member 1	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						ATCTGCTTCCGGCCAAGAACA	0.552													15	38					0	0	1	0	0	A	3406726	G	A	3406726	2	1	22	1	0	0	0	0	0	0	0	1	11039	1103	39	1		1	OR2C1	16	3406726	Silent	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		3406726	86948027	54	2331										
TRADD	8717	broad.mit.edu	37	chr16	67189313	67189313	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	atgcaactcaaacagcgctcCtcgtccgccagcaaagcgtc	8	16	1	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr16:67189313C>T	ENST00000345057.4	-	3	864	c.396G>A	c.(394-396)gaG>gaA	p.E132E	TRADD_ENST00000486556.1_Silent_p.E72E	NM_003789.3	NP_003780.1	Q15628	TRADD_HUMAN	TNFRSF1A-associated via death domain	132					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|tumor necrosis factor-mediated signaling pathway	cytoskeleton|cytosol|receptor complex	binding, bridging|death domain binding|identical protein binding|kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		AACAGCGCTCCTCGTCCGCCA	0.711													19	1					0	0	1	0	0	T	67189313	C	T	67189313	2	4	22	1	0	0	0	0	0	0	0	1	16496	680	24	3		3	TRADD	16	67189313	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	63782587	67189313	23165440	55	2332										
NLRP1	22861	broad.mit.edu	37	chr17	5485302	5485302	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cagcactgctgtggatgtggGggcgttgggtgactcctggc	18	9	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:5485302G>C	ENST00000345221.3	-	3	1083	c.529C>G	c.(529-531)Ccc>Gcc	p.P177A	NLRP1_ENST00000572272.1_Missense_Mutation_p.P177A|NLRP1_ENST00000262467.5_Missense_Mutation_p.P177A|NLRP1_ENST00000269280.4_Missense_Mutation_p.P177A|NLRP1_ENST00000354411.3_Missense_Mutation_p.P177A|NLRP1_ENST00000577119.1_Missense_Mutation_p.P177A|NLRP1_ENST00000571307.1_5'UTR	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	177					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GTGGATGTGGGGGCGTTGGGT	0.597													18	24					0	0	1	0	0	C	5485302	G	C	5485302	3	2	22	1	0	0	0	0	1	0	0	0	10517	1232	43	5	4027	5	NLRP1	17	5485302	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		5485302	75709908	56	2333										
TP53	7157	broad.mit.edu	37	chr17	7577569	7577569	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gcccatgcaggaactgttacAcatgtagttgtagtggatgg	13	7	0	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:7577569A>G	ENST00000420246.2	-	7	844	c.712T>C	c.(712-714)Tgt>Cgt	p.C238R	TP53_ENST00000269305.4_Missense_Mutation_p.C238R|TP53_ENST00000413465.2_Missense_Mutation_p.C238R|TP53_ENST00000359597.4_Missense_Mutation_p.C238R|TP53_ENST00000445888.2_Missense_Mutation_p.C238R|TP53_ENST00000455263.2_Missense_Mutation_p.C238R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	238	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238R(14)|p.C238S(12)|p.0?(8)|p.?(5)|p.C238G(4)|p.M237_N239delMCN(4)|p.C238fs*21(1)|p.C238fs*2(1)|p.M144_N146delMCN(1)|p.C238del(1)|p.Y236_M243delYMCNSSCM(1)|p.C145G(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.H233fs*6(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)|p.M237fs*1(1)|p.C238fs*9(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAACTGTTACACATGTAGTTG	0.567		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	6					0	0	1	0	0	G	7577569	A	G	7577569	3	3	22	1	0	0	0	0	1	0	0	0	16441	159	6	4	578	4	TP53	17	7577569	Missense_Mutation	SNP	A	TCGA-N7-A4Y5-01A-12D-A28R-08	2092267	7577569	73617641	57	2334										
TMEM97	27346	broad.mit.edu	37	chr17	26652535	26652535	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gttttctttttcagtttagaAacctgctgaagtggtatgct	9	6	2	2			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:26652535A>C	ENST00000226230.6	+	2	278	c.133A>C	c.(133-135)Aac>Cac	p.N45H	TMEM97_ENST00000582113.1_Missense_Mutation_p.N45H|TMEM97_ENST00000336687.6_5'UTR|TMEM97_ENST00000583381.1_5'UTR	NM_014573.2	NP_055388.2	Q5BJF2	TMM97_HUMAN	transmembrane protein 97	45					cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding			endometrium(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	6	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TCAGTTTAGAAACCTGCTGAA	0.468													53	27					0	0	1	0	0	C	26652535	A	C	26652535	3	2	22	1	0	0	0	0	1	0	0	0	16283	14	1	4	139	4	TMEM97	17	26652535	Missense_Mutation	SNP	A	TCGA-N7-A4Y5-01A-12D-A28R-08	19074966	26652535	54542675	58	2335										
RNF43	54894	broad.mit.edu	37	chr17	56434921	56434921	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cagaaggcccctccccaggtGgatgtggttccaggggctgg	16	12	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:56434921G>A	ENST00000584437.1	-	8	4171	c.2216C>T	c.(2215-2217)cCa>cTa	p.P739L	RNF43_ENST00000583753.1_Missense_Mutation_p.P698L|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000577625.1_Missense_Mutation_p.P612L|RNF43_ENST00000407977.2_Missense_Mutation_p.P739L|RNF43_ENST00000500597.2_Missense_Mutation_p.P698L|RNF43_ENST00000577716.1_Missense_Mutation_p.P739L|RNF43_ENST00000581868.1_Missense_Mutation_p.P612L			Q68DV7	RNF43_HUMAN	ring finger protein 43	739	Pro-rich.					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTCCCCAGGTGGATGTGGTTC	0.607													44	83					0	0	1	0	0	A	56434921	G	A	56434921	3	1	22	1	0	0	0	0	1	0	0	0	13546	1348	47	3	143	3	RNF43	17	56434921	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08	29782386	56434921	24760289	59	2336										
MBD1	4152	broad.mit.edu	37	chr18	47799975	47799975	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	agctgcaacagggcccggcaCctgcacaggactgcttgcgc	13	15	0	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr18:47799975C>G	ENST00000591416.1	-	12	1836	c.1405G>C	c.(1405-1407)Gtg>Ctg	p.V469L	MBD1_ENST00000339998.6_Missense_Mutation_p.V469L|MBD1_ENST00000398493.1_Missense_Mutation_p.V413L|MBD1_ENST00000398488.1_Missense_Mutation_p.V413L|MBD1_ENST00000585672.1_Missense_Mutation_p.V419L|MBD1_ENST00000587605.1_Missense_Mutation_p.V413L|MBD1_ENST00000269468.5_Missense_Mutation_p.V469L|MBD1_ENST00000585595.1_Missense_Mutation_p.V494L|MBD1_ENST00000269471.5_Missense_Mutation_p.V446L|MBD1_ENST00000457839.2_Missense_Mutation_p.V494L|MBD1_ENST00000436910.1_Missense_Mutation_p.V446L|MBD1_ENST00000424334.2_Missense_Mutation_p.V520L|MBD1_ENST00000588937.1_Missense_Mutation_p.V446L|MBD1_ENST00000398495.2_Missense_Mutation_p.V438L|MBD1_ENST00000382948.5_Missense_Mutation_p.V469L|MBD1_ENST00000353909.3_Missense_Mutation_p.V420L|MBD1_ENST00000349085.2_Missense_Mutation_p.V413L|MBD1_ENST00000591535.1_Missense_Mutation_p.V446L|MBD1_ENST00000347968.3_Missense_Mutation_p.V413L|MBD1_ENST00000590208.1_Missense_Mutation_p.V469L			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	469					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						GGGCCCGGCACCTGCACAGGA	0.642													21	20					0	0	1	0	0	G	47799975	C	G	47799975	3	3	22	1	0	0	0	0	1	0	0	0	9391	507	18	5	626	5	MBD1	18	47799975	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08		47799975	30277273	60	2337										
ICAM4	3386	broad.mit.edu	37	chr19	10398002	10398002	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ttaccagctgctcgacgtgaGggcctggagctccctcgcgc	13	15	0	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:10398002G>C	ENST00000393717.2	+	1	323	c.314G>C	c.(313-315)aGg>aCg	p.R105T	CTD-2369P2.8_ENST00000589379.1_RNA|ICAM4_ENST00000380770.3_Missense_Mutation_p.R105T|ICAM4_ENST00000340992.4_Missense_Mutation_p.R105T	NM_022377.3	NP_071772.1	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	105	Ig-like C2-type 1.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CTCGACGTGAGGGCCTGGAGC	0.667													10	29					0	0	1	0	0	C	10398002	G	C	10398002	3	2	22	1	0	0	0	0	1	0	0	0	7525	1000	35	5	316	5	ICAM4	19	10398002	Missense_Mutation	SNP	G	TCGA-N7-A4Y5-01A-12D-A28R-08		10398002	48730981	61	2338										
ARHGAP35	2909	broad.mit.edu	37	chr19	47491244	47491249	+	Splice_Site	DEL	AGGACT	AGGACT	-													0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	gaccctgcctgtttctcctcAggactgagcacggaaggcat							TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:47491244_47491249delAGGACT	ENST00000404338.3	+	3	3826_3830	c.3826_splice	c.e3-1	p.1276_splice		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1276	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity	p.G1276V(4)|p.?(2)									GTTTCTCCTCAGGACTGAGCACGGAA	0.558													14	9	---	---	---	---						-	47491249	AGGACT	-	47491244	8	5	22	1	0	1	0	1	0	0	1	0	6835	202	7	0	3835	0	ARHGAP35	19	47491244	Splice_Site	DEL	AGGACT	TCGA-N7-A4Y5-01A-12D-A28R-08	37093242	47491244	11637739	62	2339										
ZNF324B	388569	broad.mit.edu	37	chr19	58965695	58965695	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	accctggccaggaacacctaCgggaggctcaactctggtga	12	13	2	1	rs148369158	by1000genomes	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:58965695C>T	ENST00000336614.4	+	3	329	c.222C>T	c.(220-222)taC>taT	p.Y74Y	ZNF324B_ENST00000545523.1_Silent_p.Y74Y|ZNF324B_ENST00000391696.1_5'UTR|ZNF324B_ENST00000594214.1_Silent_p.Y74Y	NM_207395.2	NP_997278.2	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GGAACACCTACGGGAGGCTCA	0.577													18	55					0	0	1	0	0	T	58965695	C	T	58965695	2	4	22	1	0	0	0	0	0	0	0	1	17901	547	19	1		1	ZNF324B	19	58965695	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	11474451	58965695	163288	63	2340										
PLCB4	5332	broad.mit.edu	37	chr20	9343593	9343593	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	cacaacttcagggccaacaaCgtcagtccaatgacatgcct	7	14	2	1			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr20:9343593C>T	ENST00000378501.2	+	5	435	c.420C>T	c.(418-420)aaC>aaT	p.N140N	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Silent_p.N140N|PLCB4_ENST00000378493.1_Silent_p.N140N|PLCB4_ENST00000334005.3_Silent_p.N140N|PLCB4_ENST00000378473.3_Silent_p.N140N|PLCB4_ENST00000278655.4_Silent_p.N140N	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	140					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GGGCCAACAACGTCAGTCCAA	0.413													8	7					0	0	1	0	0	T	9343593	C	T	9343593	2	4	22	1	0	0	0	0	0	0	0	1	12077	535	19	1		1	PLCB4	20	9343593	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08		9343593	53681927	64	2341										
PYGB	5834	broad.mit.edu	37	chr20	25277119	25277119	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	atctggggtgtggagccctcCgacctgcagatcccgccccc	12	17	1	1	rs141315124	byFrequency	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr20:25277119C>T	ENST00000216962.4	+	20	2603	c.2493C>T	c.(2491-2493)tcC>tcT	p.S831S	PYGB_ENST00000471359.1_3'UTR|ABHD12_ENST00000376542.3_Intron	NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	831					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	TGGAGCCCTCCGACCTGCAGA	0.612													39	33					0	0	1	0	0	T	25277119	C	T	25277119	2	4	22	1	0	0	0	0	0	0	0	1	12911	639	23	1		1	PYGB	20	25277119	Silent	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	15933526	25277119	37748401	65	2342										
DYNLRB1	83658	broad.mit.edu	37	chr20	33122480	33122480	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.106060606060606	7	1	1.31454046639232	1.81084656084656	1.09040223018718	1	1	0	ccccaccaccacccagtatgCcagcctcatgcacagcttca	5	20	2	0			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr20:33122480C>T	ENST00000417166.2	+	3	161	c.128C>T	c.(127-129)gCc>gTc	p.A43V	DYNLRB1_ENST00000374846.3_Missense_Mutation_p.A95V|DYNLRB1_ENST00000480759.1_3'UTR|DYNLRB1_ENST00000357156.2_Missense_Mutation_p.A43V			Q9NP97	DLRB1_HUMAN	dynein, light chain, roadblock-type 1	43					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity			endometrium(1)|large_intestine(1)|lung(1)	3						ACCCAGTATGCCAGCCTCATG	0.572													4	119					0	0	1	0	0	T	33122480	C	T	33122480	3	4	22	1	0	0	0	0	1	0	0	0	4876	739	26	3	138	3	DYNLRB1	20	33122480	Missense_Mutation	SNP	C	TCGA-N7-A4Y5-01A-12D-A28R-08	7845361	33122480	29903040	66	2343										
DVL1	1855	broad.mit.edu	37	chr1	1273765	1273765	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cgtacttccgggcctcccgcCgctccttgaagccctccacg	9	20	0	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:1273765C>T	ENST00000378888.5	-	13	1675	c.1391G>A	c.(1390-1392)cGg>cAg	p.R464Q	DVL1_ENST00000378891.5_Missense_Mutation_p.R439Q			O14640	DVL1_HUMAN	dishevelled segment polarity protein 1	464	DEP.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGCCTCCCGCCGCTCCTTGAA	0.657													20	41					0	0	1	0	0	T	1273765	C	T	1273765	3	4	23	1	0	0	0	0	1	0	0	0	4861	652	23	1	708	1	DVL1	1	1273765	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		1273765	247976856	1	2344										
SRM	6723	broad.mit.edu	37	chr1	11115122	11115122	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gctgtgtcagcggctgcaccGgctcctggaagttcgtgctc	14	13	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:11115122G>A	ENST00000376957.2	-	7	865	c.785C>T	c.(784-786)cCg>cTg	p.P262L		NM_003132.2	NP_003123.2	P19623	SPEE_HUMAN	spermidine synthase	262					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity			large_intestine(1)|lung(1)|urinary_tract(1)	3	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	CGGCTGCACCGGCTCCTGGAA	0.602													30	62					0	0	1	0	0	A	11115122	G	A	11115122	3	1	23	1	0	0	0	0	1	0	0	0	15206	1116	39	1	131	1	SRM	1	11115122	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	9841357	11115122	238135499	2	2345										
SRRM1	10250	broad.mit.edu	37	chr1	24998725	24998725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgatttagaaaagcacctgcGtgaaaaggccctgagatcaa	10	8	1	4			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:24998725G>A	ENST00000323848.9	+	17	2978	c.2663G>A	c.(2662-2664)cGt>cAt	p.R888H	SRRM1_ENST00000374389.4_Missense_Mutation_p.R897H|SRRM1_ENST00000447431.2_Missense_Mutation_p.R900H	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	888					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		AAGCACCTGCGTGAAAAGGCC	0.413													14	12					0	0	1	0	0	A	24998725	G	A	24998725	3	1	23	1	0	0	0	0	1	0	0	0	15223	1145	40	1	2729	1	SRRM1	1	24998725	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	13883603	24998725	224251896	3	2346										
PTPRF	5792	broad.mit.edu	37	chr1	44057543	44057543	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ggacaccaggatccagctctCgtggctgctgccccctcagg	12	16	2	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:44057543C>A	ENST00000359947.4	+	10	1932	c.1592C>A	c.(1591-1593)tCg>tAg	p.S531*	PTPRF_ENST00000438120.1_Nonsense_Mutation_p.S531*|PTPRF_ENST00000372413.3_Nonsense_Mutation_p.S531*|PTPRF_ENST00000372414.3_Nonsense_Mutation_p.S531*|PTPRF_ENST00000422171.2_De_novo_Start_OutOfFrame	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	531	Fibronectin type-III 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATCCAGCTCTCGTGGCTGCTG	0.632													36	37					3.33393e-15	3.70437e-15	1	1	0	A	44057543	C	A	44057543	4	1	23	1	0	0	0	0	0	1	0	0	12852	893	31	2	1622	2	PTPRF	1	44057543	Nonsense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	19058818	44057543	205193078	4	2347										
NRD1	4898	broad.mit.edu	37	chr1	52272573	52272573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ggcaatcgaaagccttcaacGtaaagtccgtggctaataaa	9	9	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:52272573G>A	ENST00000354831.7	-	20	2396	c.2207C>T	c.(2206-2208)aCg>aTg	p.T736M	NRD1_ENST00000352171.7_Missense_Mutation_p.T668M|NRD1_ENST00000539524.1_Missense_Mutation_p.T604M|NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000544028.1_Missense_Mutation_p.T536M	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	667					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						AGCCTTCAACGTAAAGTCCGT	0.373													20	67					0	0	1	0	0	A	52272573	G	A	52272573	3	1	23	1	0	0	0	0	1	0	0	0	10692	1145	40	1	1508	1	NRD1	1	52272573	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	8215030	52272573	196978048	5	2348										
PDE4DIP	9659	broad.mit.edu	37	chr1	144931280	144931280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tcctggatctgatcctcattCtccacccagcactcaaaccc	4	18	4	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:144931280C>T	ENST00000529945.1	-	1	868	c.429G>A	c.(427-429)gaG>gaA	p.E143E	PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313431.9_Silent_p.E143E			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0			K -> E (in dbSNP:rs1747958).		cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GATCCTCATTCTCCACCCAGC	0.582			T	PDGFRB	MPD								67	209					0	0	1	0	0	T	144931280	C	T	144931280	2	4	23	1	0	0	0	0	0	0	0	1	11689	912	32	3		3	PDE4DIP	1	144931280	Silent	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	92658707	144931280	104319341	6	2349										
SEC22B	9554	broad.mit.edu	37	chr1	145100672	145100673	+	RNA	INS	-	-	T													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ctaattccatcttgcctttcINSttttttttttttttttgaga					rs149064633		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:145100672_145100673insT	ENST00000453618.1	+	0	402							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TCTTGCCtttcttttttttttt	0.396													4	5	---	---	---	---						T	145100673	-	T	145100672	6	5	23	0	1	1	1	0	0	0	0	0	14042	928	32	0		0	SEC22B	1	145100672	RNA	INS	-	TCGA-N7-A4Y8-01A-11D-A28R-08	169392	145100672	104149949	7	2350										
SEC22B	9554	broad.mit.edu	37	chr1	145101606	145101606	+	RNA	DEL	T	T	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	acagtaatgtttacagtgccTcttgtaaagtcaaaggattt					rs113062007		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:145101606delT	ENST00000453618.1	+	0	402							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TTACAGTGCCTCTTGTAAAGT	0.358													5	4	---	---	---	---						-	145101606	T	-	145101606	6	5	23	0	1	1	0	1	0	0	0	0	14042	1566	54	0		0	SEC22B	1	145101606	RNA	DEL	T	TCGA-N7-A4Y8-01A-11D-A28R-08	934	145101606	104149015	8	2351										
LRRN2	10446	broad.mit.edu	37	chr1	204588977	204588977	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cagtccacagtggtagcctcGcggtaggacgagcggggcgt	17	11	0	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:204588977G>A	ENST00000367175.1	-	1	2356	c.144C>T	c.(142-144)cgC>cgT	p.R48R	LRRN2_ENST00000367177.3_Silent_p.R48R|LRRN2_ENST00000367176.3_Silent_p.R48R			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	48	LRRNT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TGGTAGCCTCGCGGTAGGACG	0.657													23	77					0	0	1	0	0	A	204588977	G	A	204588977	2	1	23	1	0	0	0	0	0	0	0	1	9079	1074	38	1		1	LRRN2	1	204588977	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	59487371	204588977	44661644	9	2352										
ACTA1	58	broad.mit.edu	37	chr1	229568733	229568733	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tctgcggaggggcagcctgaCctggtgtcgggggcggccca	19	12	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:229568733C>A	ENST00000366684.3	-	2	232		c.e2+1		ACTA1_ENST00000366683.2_Splice_Site	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle						muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GGCAGCCTGACCTGGTGTCGG	0.721													20	61					8.10497e-08	8.78852e-08	1	1	0	A	229568733	C	A	229568733	5	1	23	1	0	0	0	0	0	0	1	0	191	521	18	5	1027	5	ACTA1	1	229568733	Splice_Site	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	24979756	229568733	19681888	10	2353										
CHRM3	1131	broad.mit.edu	37	chr1	240070975	240070975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ggtcttcatcgctttcttaaCgggcatcctggccttggtga	11	11	3	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr1:240070975C>T	ENST00000255380.4	+	5	1003	c.224C>T	c.(223-225)aCg>aTg	p.T75M		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	75					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GCTTTCTTAACGGGCATCCTG	0.507													23	71					0	0	1	0	0	T	240070975	C	T	240070975	3	4	23	1	0	0	0	0	1	0	0	0	3400	536	19	1	226	1	CHRM3	1	240070975	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	10502242	240070975	9179646	11	2354										
CCDC104	112942	broad.mit.edu	37	chr2	55771473	55771473	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ctaaacagatacaaaatatgGagcagaaaggaaaacccact	7	8	0	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr2:55771473G>C	ENST00000349456.4	+	9	1043	c.895G>C	c.(895-897)Gag>Cag	p.E299Q	CCDC104_ENST00000407816.3_Missense_Mutation_p.E270Q|CCDC104_ENST00000339012.3_Missense_Mutation_p.E324Q			Q96G28	CC104_HUMAN	coiled-coil domain containing 104	299										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(2)|lung(1)|ovary(2)	14			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACAAAATATGGAGCAGAAAGG	0.398													35	47					0	0	1	0	0	C	55771473	G	C	55771473	3	2	23	1	0	0	0	0	1	0	0	0	2757	1175	41	2	929	2	CCDC104	2	55771473	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		55771473	187427900	12	2355										
IL1R2	7850	broad.mit.edu	37	chr2	102632493	102632493	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tcacccgtgacaaaactgacGtgaagattcaatggtacaag	9	9	2	4			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr2:102632493G>C	ENST00000332549.3	+	4	722	c.493G>C	c.(493-495)Gtg>Ctg	p.V165L	IL1R2_ENST00000441002.1_Missense_Mutation_p.V165L|IL1R2_ENST00000393414.2_Missense_Mutation_p.V165L	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	165	Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	CAAAACTGACGTGAAGATTCA	0.373													11	40					0	0	1	0	0	C	102632493	G	C	102632493	3	2	23	1	0	0	0	0	1	0	0	0	7702	1145	40	5	503	5	IL1R2	2	102632493	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	46861020	102632493	140566880	13	2356										
GCC2	9648	broad.mit.edu	37	chr2	109104168	109104168	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gttataggcagaacaagctaCtgtaacctctgaattcgaga	9	8	1	3			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr2:109104168C>A	ENST00000309863.6	+	17	4658	c.3944C>A	c.(3943-3945)aCt>aAt	p.T1315N		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1315					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						GAACAAGCTACTGTAACCTCT	0.348													5	127					0.000602214	0.000615901	1	1	0	A	109104168	C	A	109104168	3	1	23	1	0	0	0	0	1	0	0	0	6325	565	20	5	4010	5	GCC2	2	109104168	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	6471675	109104168	134095205	14	2357										
LAMB2	3913	broad.mit.edu	37	chr3	49167320	49167320	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gagcccaaagaagccatcacGgcattgctggcagcgagtgc	13	12	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:49167320G>C	ENST00000418109.1	-	11	1521	c.1357C>G	c.(1357-1359)Cgt>Ggt	p.R453G	LAMB2_ENST00000305544.4_Missense_Mutation_p.R453G	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	453	Laminin EGF-like 3.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AAGCCATCACGGCATTGCTGG	0.582													5	165					0	0	1	0	0	C	49167320	G	C	49167320	3	2	23	1	0	0	0	0	1	0	0	0	8649	1116	39	5	4131	5	LAMB2	3	49167320	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		49167320	148855110	15	2358										
BSN	8927	broad.mit.edu	37	chr3	49694637	49694637	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	aggagcagtgggaggccagcCgtagtggcatcaagaagcgg	18	8	1	1	rs150764510	by1000genomes	TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:49694637C>T	ENST00000296452.4	+	5	7762	c.7648C>T	c.(7648-7650)Cgt>Tgt	p.R2550C		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2550					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGAGGCCAGCCGTAGTGGCAT	0.627													23	30					0	0	1	0	0	T	49694637	C	T	49694637	3	4	23	1	0	0	0	0	1	0	0	0	1532	652	23	1	7666	1	BSN	3	49694637	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	527317	49694637	148327793	16	2359										
OR5K1	26339	broad.mit.edu	37	chr3	98189040	98189041	+	Frame_Shift_Del	DEL	AA	AA	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	catcttctcaggttcagttcAagtctttaccataggtagtg							TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:98189040_98189041delAA	ENST00000332650.5	+	1	717_718	c.620_621delAA	c.(619-621)cfs	p.Q207fs		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GGTTCAGTTCAAGTCTTTACCA	0.342													46	70	---	---	---	---						-	98189041	AA	-	98189040	7	5	23	1	0	1	0	1	0	0	0	0	11212	130	5	0	622	0	OR5K1	3	98189040	Frame_Shift_Del	DEL	AA	TCGA-N7-A4Y8-01A-11D-A28R-08	48494403	98189040	99833390	17	2360										
TRPC1	7220	broad.mit.edu	37	chr3	142443429	142443429	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cggccctgtacccgagcacgGacctctcgggcgcctcctcc	11	20	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:142443429G>T	ENST00000273482.6	+	1	419	c.28G>T	c.(28-30)Gac>Tac	p.D10Y	TRPC1_ENST00000476941.1_Missense_Mutation_p.D10Y	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	10					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						CCCGAGCACGGACCTCTCGGG	0.716													9	21					0.0477658	0.0477658	1	1	0	T	142443429	G	T	142443429	3	4	23	1	0	0	0	0	1	0	0	0	16638	1174	41	2	30	2	TRPC1	3	142443429	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	44254389	142443429	55579001	18	2361										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			13	36					0	0	1	0	0	A	178936091	G	A	178936091	3	1	23	1	0	0	0	0	1	0	0	0	11960	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	36492662	178936091	19086339	19	2362										
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	77					0	0	1	0	0	G	178952085	A	G	178952085	3	3	23	1	0	0	0	0	1	0	0	0	11960	217	8	4	3218	4	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08	15994	178952085	19070345	20	2363										
MUC4	4585	broad.mit.edu	37	chr3	195505787	195505787	+	Missense_Mutation	SNP	C	C	T													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ggtgacaggaagaggggtggCgtgacctgtggatgctgagg					rs11915935		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:195505787C>T	ENST00000463781.3	-	2	13123	c.12664G>A	c.(12664-12666)Gcc>Acc	p.A4222T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.A4222T|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	979					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAGGGGTGGCGTGACCTGTG	0.587													3	19					0	0	1	0	0	T	195505787	C	T	195505787	3	4	23	1	0	0	0	0	1	0	0	0	10025	768	27	1		1	MUC4	3	195505787	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	16553702	195505787	2516643	21	2364	11	2								
MUC4	4585	broad.mit.edu	37	chr3	195505790	195505790	+	Missense_Mutation	SNP	G	G	C													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gacaggaagaggggtggcgtGacctgtggatgctgaggaag					rs11928301		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:195505790G>C	ENST00000463781.3	-	2	13120	c.12661C>G	c.(12661-12663)Cac>Gac	p.H4221D	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.H4221D|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	978					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGGTGGCGTGACCTGTGGAT	0.587													3	19					0	0	1	0	0	C	195505790	G	C	195505790	3	2	23	1	0	0	0	0	1	0	0	0	10025	1290	45	2		2	MUC4	3	195505790	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	3	195505790	2516640	22	2365	11	2								
MUC4	4585	broad.mit.edu	37	chr3	195510996	195510996	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cctgtggatactgacgaagcGtcggtgacaagaagaggggt	16	7	0	4			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr3:195510996G>A	ENST00000463781.3	-	2	7914	c.7455C>T	c.(7453-7455)gaC>gaT	p.D2485D	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.D2485D|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	243					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGACGAAGCGTCGGTGACAA	0.582													4	18					0	0	1	0	0	A	195510996	G	A	195510996	2	1	23	1	0	0	0	0	0	0	0	1	10025	1136	40	1		1	MUC4	3	195510996	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	5206	195510996	2511434	23	2366										
ZNF518B	85460	broad.mit.edu	37	chr4	10445064	10445064	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	acattgcctttgtatttattTattaccttcatcacattggt	4	8	2	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr4:10445064T>C	ENST00000326756.3	-	3	3327	c.2889A>G	c.(2887-2889)atA>atG	p.I963M		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	963					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TGTATTTATTTATTACCTTCA	0.458													4	77					0	0	1	0	0	C	10445064	T	C	10445064	3	2	23	1	0	0	0	0	1	0	0	0	18019	1744	61	4	339	4	ZNF518B	4	10445064	Missense_Mutation	SNP	T	TCGA-N7-A4Y8-01A-11D-A28R-08		10445064	180709212	24	2367										
LPHN3	23284	broad.mit.edu	37	chr4	62845387	62845387	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cttcacattttgctttttccGggggctccagagtgaccgta	10	11	1	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr4:62845387G>A	ENST00000512091.1	+	17	3455	c.2708G>A	c.(2707-2709)cGg>cAg	p.R903Q	LPHN3_ENST00000514157.1_Missense_Mutation_p.R903Q|LPHN3_ENST00000509896.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000504896.1_Missense_Mutation_p.R903Q|LPHN3_ENST00000507164.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000508946.1_Missense_Mutation_p.R903Q|LPHN3_ENST00000506720.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000514996.1_Missense_Mutation_p.R903Q|LPHN3_ENST00000507625.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000514591.1_Missense_Mutation_p.R903Q|LPHN3_ENST00000511324.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000506746.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000545650.1_Missense_Mutation_p.R903Q|LPHN3_ENST00000508693.1_Missense_Mutation_p.R971Q|LPHN3_ENST00000506700.1_Missense_Mutation_p.R903Q			Q9HAR2	LPHN3_HUMAN	latrophilin 3	890					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TGCTTTTTCCGGGGGCTCCAG	0.493													76	75					0	0	1	0	0	A	62845387	G	A	62845387	3	1	23	1	0	0	0	0	1	0	0	0	8961	1116	39	1	2766	1	LPHN3	4	62845387	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	52400323	62845387	128308889	25	2368										
FBXW7	0	broad.mit.edu	37	chr4	153249385	153249385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ttcatgaagatgcatacaacGcacagtggaagtatgcccat	9	9	1	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr4:153249385G>A	ENST00000281708.4	-	9	2622	c.1393C>T	c.(1393-1395)Cgt>Tgt	p.R465C	FBXW7_ENST00000603548.1_Missense_Mutation_p.R465C|FBXW7_ENST00000296555.5_Missense_Mutation_p.R347C|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385C|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465C|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289C	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465C(71)|p.R226C(11)|p.R385C(11)|p.R347C(3)|p.R465Y(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCATACAACGCACAGTGGAA	0.413			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								31	68					0	0	1	0	0	A	153249385	G	A	153249385	3	1	23	1	0	0	0	0	1	0	0	0	5801	1087	38	1	746	1	FBXW7	4	153249385	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	90403998	153249385	37904891	26	2369										
NPY2R	4887	broad.mit.edu	37	chr4	156135433	156135433	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cttacctataccttaatgggGgagtggaaaatgggtcctgt	12	7	0	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr4:156135433G>A	ENST00000329476.3	+	2	831	c.342G>A	c.(340-342)ggG>ggA	p.G114G	NPY2R_ENST00000506608.1_Silent_p.G114G	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	114					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CCTTAATGGGGGAGTGGAAAA	0.507													20	19					0	0	1	0	0	A	156135433	G	A	156135433	2	1	23	1	0	0	0	0	0	0	0	1	10656	1219	43	3		3	NPY2R	4	156135433	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	2886048	156135433	35018843	27	2370										
IRF2	3660	broad.mit.edu	37	chr4	185340713	185340715	+	In_Frame_Del	DEL	TCT	TCT	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	catccaggggatctgaaaaaTcttcttttcctgaaaaaaaa							TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr4:185340713_185340715delTCT	ENST00000393593.3	-	3	302_304	c.95_97delAGA	c.(94-99)att>a	p.KI32del	IRF2_ENST00000512020.1_5'UTR	NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	32					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		ATCTGAAAAATCTTCTTTTCCTG	0.414													8	26	---	---	---	---						-	185340715	TCT	-	185340713	7	5	23	1	0	1	0	1	0	0	0	0	7871	1435	50	0	980	0	IRF2	4	185340713	In_Frame_Del	DEL	TCT	TCGA-N7-A4Y8-01A-11D-A28R-08	29205280	185340713	5813563	28	2371										
ITGA1	3672	broad.mit.edu	37	chr5	52193289	52193289	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	attttcctatgttatagccaCagctgaccagtcagcagctt	7	11	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr5:52193289C>T	ENST00000282588.6	+	10	1552	c.1094C>T	c.(1093-1095)aCa>aTa	p.T365I		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	365					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GTTATAGCCACAGCTGACCAG	0.393													6	6					0	0	1	0	0	T	52193289	C	T	52193289	3	4	23	1	0	0	0	0	1	0	0	0	7915	478	17	3	1132	3	ITGA1	5	52193289	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		52193289	128721971	29	2372										
TMEM173	340061	broad.mit.edu	37	chr5	138860776	138860776	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gaggatgttcagtgcctgcgAgaggcccaggagggcaagca	17	9	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr5:138860776A>T	ENST00000330794.4	-	4	712	c.379T>A	c.(379-381)Tcg>Acg	p.S127T	TMEM173_ENST00000511850.1_5'UTR	NM_198282.2	NP_938023.1	Q86WV6	TM173_HUMAN	transmembrane protein 173	127					activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			endometrium(1)|kidney(1)|lung(6)|upper_aerodigestive_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGTGCCTGCGAGAGGCCCAGG	0.622													36	42					0	0	1	0	0	T	138860776	A	T	138860776	3	4	23	1	0	0	0	0	1	0	0	0	16148	304	11	4	780	4	TMEM173	5	138860776	Missense_Mutation	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08	86667487	138860776	42054484	30	2373										
PCDHA12	0	broad.mit.edu	37	chr5	140257222	140257222	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gctgctgtacactgcgctgcGttgctcagcgccgcccaccg	12	17	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr5:140257222G>A	ENST00000398631.2	+	1	2165	c.2165G>A	c.(2164-2166)cGt>cAt	p.R722H	PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGCTGCGTTGCTCAGCG	0.657													31	43					0	0	1	0	0	A	140257222	G	A	140257222	3	1	23	1	0	0	0	0	1	0	0	0	11568	1145	40	1	2167	1	PCDHA12	5	140257222	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	1396446	140257222	40658038	31	2374										
GEMIN5	25929	broad.mit.edu	37	chr5	154299598	154299598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	actaagcttccagggattatGctgtaagacaatcccttctc	7	11	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr5:154299598G>A	ENST00000285873.7	-	11	1603	c.1528C>T	c.(1528-1530)Cat>Tat	p.H510Y		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	510					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGGGATTATGCTGTAAGACA	0.413													16	16					0	0	1	0	0	A	154299598	G	A	154299598	3	1	23	1	0	0	0	0	1	0	0	0	6372	1319	46	3	3070	3	GEMIN5	5	154299598	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	14042376	154299598	26615662	32	2375										
NUP153	9972	broad.mit.edu	37	chr6	17637615	17637615	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tccaggtttcggtgtttcacAggctacacattttattgctt	8	9	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr6:17637615A>C	ENST00000262077.2	-	16	2232	c.2233T>G	c.(2233-2235)Tgt>Ggt	p.C745G	NUP153_ENST00000537253.1_Missense_Mutation_p.C776G	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	745					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GGTGTTTCACAGGCTACACAT	0.443													42	116					0	0	1	0	0	C	17637615	A	C	17637615	3	2	23	1	0	0	0	0	1	0	0	0	10802	188	7	4	2222	4	NUP153	6	17637615	Missense_Mutation	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08		17637615	153477452	33	2376										
HLA-E	3133	broad.mit.edu	37	chr6	30457613	30457613	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cccagttcgtgcgcttcgacAacgacgccgcgagtccgagg	13	15	0	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr6:30457613A>G	ENST00000376630.4	+	2	240	c.175A>G	c.(175-177)Aac>Gac	p.N59D		NM_005516.5	NP_005507.3	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	59	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(2)|lung(1)|ovary(3)|skin(1)|urinary_tract(1)	18						GCGCTTCGACAACGACGCCGC	0.672													32	87					0	0	1	0	0	G	30457613	A	G	30457613	3	3	23	1	0	0	0	0	1	0	0	0	7250	130	5	4	181	4	HLA-E	6	30457613	Missense_Mutation	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08	12819998	30457613	140657454	34	2377										
DEFB112	245915	broad.mit.edu	37	chr6	50011295	50011295	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgcatggatttcttcaatgaCgtgagtctttagggtaccat	10	7	3	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr6:50011295C>T	ENST00000322246.4	-	2	334	c.335G>A	c.(334-336)cGt>cAt	p.R112H		NM_001037498.1	NP_001032587.1	Q30KQ8	DB112_HUMAN	defensin, beta 112	112					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.042)					TCTTCAATGACGTGAGTCTTT	0.403													10	15					0	0	1	0	0	T	50011295	C	T	50011295	3	4	23	1	0	0	0	0	1	0	0	0	4428	536	19	1	9	1	DEFB112	6	50011295	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	19553682	50011295	121103772	35	2378										
TBP	6908	broad.mit.edu	37	chr6	170871040	170871040	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cagcagcagcagcagcagcaAcagcaacagcagcagcagca	11	14	0	0	rs10592950		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr6:170871040A>G	ENST00000392092.2	+	3	495	c.216A>G	c.(214-216)caA>caG	p.Q72Q	TBP_ENST00000230354.6_Silent_p.Q72Q|TBP_ENST00000540980.1_Silent_p.Q52Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	72	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q72del(3)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcaacagcaacagc	0.567													4	79					0	0	1	0	0	G	170871040	A	G	170871040	2	3	23	1	0	0	0	0	0	0	0	1	15703	40	2	4		4	TBP	6	170871040	Silent	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08	120859745	170871040	244027	36	2379										
ELN	2006	broad.mit.edu	37	chr7	73470684	73470684	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ccggctttggtgtcggagtcGgaggtatccctggagtcgca	16	10	0	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr7:73470684G>A	ENST00000252034.7	+	20	1633	c.1234G>A	c.(1234-1236)Gga>Aga	p.G412R	ELN_ENST00000414324.1_Missense_Mutation_p.G407R|ELN_ENST00000380553.4_Missense_Mutation_p.G295R|ELN_ENST00000380562.4_Missense_Mutation_p.G412R|ELN_ENST00000380575.4_Missense_Mutation_p.G402R|ELN_ENST00000380576.5_Missense_Mutation_p.G412R|ELN_ENST00000380584.4_Missense_Mutation_p.G398R|ELN_ENST00000358929.4_Missense_Mutation_p.G412R|ELN_ENST00000357036.5_Missense_Mutation_p.G417R|ELN_ENST00000320399.6_Missense_Mutation_p.G412R|ELN_ENST00000320492.7_Missense_Mutation_p.G376R|ELN_ENST00000429192.1_Missense_Mutation_p.G417R|ELN_ENST00000458204.1_Missense_Mutation_p.G402R|ELN_ENST00000445912.1_Missense_Mutation_p.G412R|ELN_ENST00000466878.1_3'UTR	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	412	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGTCGGAGTCGGAGGTATCCC	0.637			T	PAX5	B-ALL		"Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"						51	118					0	0	1	0	0	A	73470684	G	A	73470684	3	1	23	1	0	0	0	0	1	0	0	0	5099	1117	39	1	1327	1	ELN	7	73470684	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		73470684	85667979	37	2380										
RBM28	55131	broad.mit.edu	37	chr7	127958088	127958088	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgctcgtgctcttggaactcCgcaaaggcgtagcccaggga	13	12	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr7:127958088C>T	ENST00000223073.1	-	15	1749	c.1635G>A	c.(1633-1635)gcG>gcA	p.A545A	RBM28_ENST00000481788.1_Intron|RBM28_ENST00000415472.2_Silent_p.A404A	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	545	RRM 4.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						CTTGGAACTCCGCAAAGGCGT	0.512													15	28					0	0	1	0	0	T	127958088	C	T	127958088	2	4	23	1	0	0	0	0	0	0	0	1	13179	639	23	1		1	RBM28	7	127958088	Silent	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	54487404	127958088	31180575	38	2381										
PDIA4	9601	broad.mit.edu	37	chr7	148701262	148701262	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgacgggtcccttgttgttcTtgggcactggctgggatttg	15	8	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr7:148701262T>G	ENST00000286091.4	-	10	1794	c.1562A>C	c.(1561-1563)aAg>aCg	p.K521T		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	521	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CTTGTTGTTCTTGGGCACTGG	0.562													5	174					0	0	1	0	0	G	148701262	T	G	148701262	3	3	23	1	0	0	0	0	1	0	0	0	11716	1609	56	4	379	4	PDIA4	7	148701262	Missense_Mutation	SNP	T	TCGA-N7-A4Y8-01A-11D-A28R-08	20743174	148701262	10437401	39	2382										
PDIA4	9601	broad.mit.edu	37	chr7	148702238	148702238	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cagccacgggctcaccttttTtgaaagcagtgacaaactcg	9	12	1	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr7:148702238T>C	ENST00000286091.4	-	9	1749	c.1517A>G	c.(1516-1518)aAa>aGa	p.K506R		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	506	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CTCACCTTTTTTGAAAGCAGT	0.607													62	162					0	0	1	0	0	C	148702238	T	C	148702238	3	2	23	1	0	0	0	0	1	0	0	0	11716	1841	64	4	428	4	PDIA4	7	148702238	Missense_Mutation	SNP	T	TCGA-N7-A4Y8-01A-11D-A28R-08	976	148702238	10436425	40	2383										
SSPO	23145	broad.mit.edu	37	chr7	149497429	149497429	+	RNA	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gcagtgtggccccggccagaCgccctgtgaggtgctgggct	17	13	0	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr7:149497429C>T	ENST00000378016.2	+	0	7187							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCGGCCAGACGCCCTGTGAG	0.687													10	19					0	0	1	0	0	T	149497429	C	T	149497429	1	4	23	0	1	0	0	0	0	0	0	0	15244	536	19	1		1	SSPO	7	149497429	RNA	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	795191	149497429	9641234	41	2384										
NRG1	3084	broad.mit.edu	37	chr8	32616940	32616940	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cactccactactgtcacccaGactcctagccacaggtatga	6	16	1	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr8:32616940G>T	ENST00000338921.4	+	11	1588	c.1071G>T	c.(1069-1071)caG>caT	p.Q357H	NRG1_ENST00000521670.1_Missense_Mutation_p.Q349H|NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000405005.2_Missense_Mutation_p.Q349H|NRG1_ENST00000287845.5_Missense_Mutation_p.Q320H|NRG1_ENST00000287840.5_Missense_Mutation_p.Q349H|NRG1_ENST00000287842.3_Missense_Mutation_p.Q346H|NRG1_ENST00000539990.1_Missense_Mutation_p.Q192H|NRG1_ENST00000519301.1_Missense_Mutation_p.Q299H|NRG1_ENST00000523079.1_Missense_Mutation_p.Q346H|NRG1_ENST00000356819.4_Missense_Mutation_p.Q354H			Q02297	NRG1_HUMAN	neuregulin 1	349					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CTGTCACCCAGACTCCTAGCC	0.448													20	66					9.7654e-05	0.000102196	1	1	0	T	32616940	G	T	32616940	3	4	23	1	0	0	0	0	1	0	0	0	10694	933	33	2	2681	2	NRG1	8	32616940	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		32616940	113747082	42	2385										
SLC7A13	157724	broad.mit.edu	37	chr8	87229900	87229900	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgactattaagtgtattaaaTagcaaaggcagctggccctc	9	8	0	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr8:87229900T>G	ENST00000297524.3	-	3	1081	c.978A>C	c.(976-978)ctA>ctC	p.L326L	SLC7A13_ENST00000419776.2_Silent_p.L317L|SLC7A13_ENST00000520624.1_5'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	326						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						GTGTATTAAATAGCAAAGGCA	0.358													6	146					0	0	1	0	0	G	87229900	T	G	87229900	2	3	23	1	0	0	0	0	0	0	0	1	14749	1393	49	4		4	SLC7A13	8	87229900	Silent	SNP	T	TCGA-N7-A4Y8-01A-11D-A28R-08	54612960	87229900	59134122	43	2386										
SYBU	55638	broad.mit.edu	37	chr8	110590123	110590123	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tggagtcggcgctcagattcCttcagcttggttttgaggtg	14	8	2	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr8:110590123C>T	ENST00000399066.3	-	5	1576	c.849G>A	c.(847-849)aaG>aaA	p.K283K	SYBU_ENST00000532779.1_Silent_p.K218K|SYBU_ENST00000529690.1_Silent_p.K156K|SYBU_ENST00000527707.1_5'UTR|SYBU_ENST00000424158.2_Silent_p.K291K|SYBU_ENST00000433638.1_Silent_p.K286K|SYBU_ENST00000408908.2_Silent_p.K286K|SYBU_ENST00000440310.1_Silent_p.K286K|SYBU_ENST00000528331.1_Silent_p.K167K|SYBU_ENST00000408889.3_Silent_p.K167K|SYBU_ENST00000533895.1_Silent_p.K285K|SYBU_ENST00000533065.1_Silent_p.K167K|SYBU_ENST00000446070.2_Silent_p.K285K|SYBU_ENST00000533171.1_Silent_p.K286K|SYBU_ENST00000276646.9_Silent_p.K286K|SYBU_ENST00000529175.1_Silent_p.K80K|SYBU_ENST00000528647.1_Silent_p.K285K|SYBU_ENST00000422135.1_Silent_p.K286K|SYBU_ENST00000419099.1_Silent_p.K285K	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	286	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						GCTCAGATTCCTTCAGCTTGG	0.478													48	122					0	0	1	0	0	T	110590123	C	T	110590123	2	4	23	1	0	0	0	0	0	0	0	1	15482	680	24	3		3	SYBU	8	110590123	Silent	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	23360223	110590123	35773899	44	2387										
ZNF251	90987	broad.mit.edu	37	chr8	145948368	145948368	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cagtgtgacttctctggtgtCtacttaggtctgaattatat	9	7	3	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr8:145948368C>T	ENST00000292562.7	-	5	952	c.677G>A	c.(676-678)aGa>aAa	p.R226K	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTCTGGTGTCTACTTAGGTC	0.428													51	51					0	0	1	0	0	T	145948368	C	T	145948368	3	4	23	1	0	0	0	0	1	0	0	0	17853	913	32	3	1342	3	ZNF251	8	145948368	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	35358245	145948368	415654	45	2388										
COL15A1	1306	broad.mit.edu	37	chr9	101748168	101748168	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	catcctctactacacggagcCaggctcccatgtgtcccaag	8	16	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr9:101748168C>G	ENST00000375001.3	+	3	845	c.422C>G	c.(421-423)cCa>cGa	p.P141R		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	141	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TACACGGAGCCAGGCTCCCAT	0.607													11	86					0	0	1	0	0	G	101748168	C	G	101748168	3	3	23	1	0	0	0	0	1	0	0	0	3695	594	21	5	432	5	COL15A1	9	101748168	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		101748168	39465263	46	2389										
SLC44A1	23446	broad.mit.edu	37	chr9	108118561	108118569	+	In_Frame_Del	DEL	CCCTGATCA	CCCTGATCA	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ctatgccaagtttgcagaggCcctgatcacctttgtcagtg					rs41306484	byFrequency	TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr9:108118561_108118569delCCCTGATCA	ENST00000374720.3	+	6	816_824	c.569_577delCCCTGATCA	c.(568-579)gcc>g	p.ALIT190del	SLC44A1_ENST00000374723.1_In_Frame_Del_p.ALIT190del|SLC44A1_ENST00000374724.1_In_Frame_Del_p.ALIT190del|SLC44A1_ENST00000343170.7_5'UTR	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	190						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	TTTGCAGAGGCCCTGATCACCTTTGTCAG	0.407													9	40	---	---	---	---						-	108118569	CCCTGATCA	-	108118561	7	5	23	1	0	1	0	1	0	0	0	0	14689	739	26	0	591	0	SLC44A1	9	108118561	In_Frame_Del	DEL	CCCTGATCA	TCGA-N7-A4Y8-01A-11D-A28R-08	6370393	108118561	33094870	47	2390										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123169430	123169430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gagtgctgctggtttcgatgCtcctttctagttgcaagcgc	12	10	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr9:123169430C>T	ENST00000349780.4	-	32	5002	c.4823G>A	c.(4822-4824)aGc>aAc	p.S1608N	CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.S1567N|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.S1576N|CDK5RAP2_ENST00000360190.4_Intron	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1608					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						GGTTTCGATGCTCCTTTCTAG	0.602													25	38					0	0	1	0	0	T	123169430	C	T	123169430	3	4	23	1	0	0	0	0	1	0	0	0	3168	797	28	3	886	3	CDK5RAP2	9	123169430	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	15050869	123169430	18044001	48	2391										
PRRX2	51450	broad.mit.edu	37	chr9	132481518	132481518	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	caacctccgcaggtgagtgtCccagcccggggcgcggtagc	15	15	0	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr9:132481518C>T	ENST00000372469.4	+	2	495	c.268C>T	c.(268-270)Ccc>Tcc	p.P90S		NM_016307.3	NP_057391.1	Q99811	PRRX2_HUMAN	paired related homeobox 2	90				P -> S (in Ref. 5; AAB39864).		nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|pancreas(1)	3		Ovarian(14;0.00556)				AGGTGAGTGTCCCAGCCCGGG	0.657													9	7					0	0	1	0	0	T	132481518	C	T	132481518	3	4	23	1	0	0	0	0	1	0	0	0	12662	855	30	3	274	3	PRRX2	9	132481518	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	9312088	132481518	8731913	49	2392										
CEL	1056	broad.mit.edu	37	chr9	135946988	135946988	+	Frame_Shift_Del	DEL	C	C	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gcccacgggtgactccggggCcccccccgtgacccccacgg							TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr9:135946988delC	ENST00000372080.4	+	11	2124	c.2108delC	c.(2107-2109)gcfs	p.A703fs	CEL_ENST00000351304.7_Frame_Shift_Del_p.A634fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	700	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GACTCCGGGGCCCCCCCCGTG	0.821													3	4	---	---	---	---						-	135946988	C	-	135946988	7	5	23	1	0	1	0	1	0	0	0	0	3231	739	26	0	2150	0	CEL	9	135946988	Frame_Shift_Del	DEL	C	TCGA-N7-A4Y8-01A-11D-A28R-08	3465470	135946988	5266443	50	2393										
BMS1	9790	broad.mit.edu	37	chr10	43317508	43317508	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	caaattttggggttcctgttAgcctgattttcggatagctg	11	7	0	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr10:43317508A>G	ENST00000374518.4	+	19	3072		c.e19-1			NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GGTTCCTGTTAGCCTGATTTT	0.308													16	57					0	0	1	0	0	G	43317508	A	G	43317508	5	3	23	1	0	0	0	0	0	0	1	0	1471	434	15	4	3078	4	BMS1	10	43317508	Splice_Site	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08		43317508	92217239	51	2394										
MUC5B	727897	broad.mit.edu	37	chr11	1268462	1268462	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	acccccagtgccgaacaccaCggccaccacacacgggcggt	10	19	0	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr11:1268462C>T	ENST00000447027.1	+	31	10419	c.10361C>T	c.(10360-10362)aCg>aTg	p.T3454M	MUC5B_ENST00000529681.1_Missense_Mutation_p.T3451M|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3451	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCGAACACCACGGCCACCACA	0.687													11	55					0	0	1	0	0	T	1268462	C	T	1268462	3	4	23	1	0	0	0	0	1	0	0	0	10026	536	19	1	10483	1	MUC5B	11	1268462	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		1268462	133738054	52	2395										
TH	7054	broad.mit.edu	37	chr11	2186489	2186489	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgtccttggcgtcactgaagCtctcagacacgaagtagact	10	11	2	3			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr11:2186489C>T	ENST00000381178.1	-	13	1418	c.1400G>A	c.(1399-1401)aGc>aAc	p.S467N	TH_ENST00000381175.1_Missense_Mutation_p.S463N|TH_ENST00000333684.5_Missense_Mutation_p.S346N|TH_ENST00000352909.3_Missense_Mutation_p.S436N	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	467					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GTCACTGAAGCTCTCAGACAC	0.622													6	85					0	0	1	0	0	T	2186489	C	T	2186489	3	4	23	1	0	0	0	0	1	0	0	0	15897	797	28	3	194	3	TH	11	2186489	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	918027	2186489	132820027	53	2396										
OR4C12	283093	broad.mit.edu	37	chr11	50003749	50003749	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gtgttctgcataggcttgagCcatacacccattaaaggaga	10	9	1	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr11:50003749C>A	ENST00000335238.4	-	1	322	c.289G>T	c.(289-291)Gct>Tct	p.A97S		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						TAGGCTTGAGCCATACACCCA	0.423													32	83					3.99451e-17	4.49382e-17	1	1	0	A	50003749	C	A	50003749	3	1	23	1	0	0	0	0	1	0	0	0	11093	739	26	5	644	5	OR4C12	11	50003749	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	47817260	50003749	85002767	54	2397										
YPEL4	219539	broad.mit.edu	37	chr11	57413796	57413796	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ccagcccagtgtggttttgcAgctctcacagaaaatgtcag	10	11	2	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr11:57413796A>G	ENST00000524669.1	-	4	2990	c.268T>C	c.(268-270)Tgc>Cgc	p.C90R	YPEL4_ENST00000544993.1_Missense_Mutation_p.C90R|YPEL4_ENST00000534711.1_Missense_Mutation_p.C90R|YPEL4_ENST00000300022.3_Missense_Mutation_p.C90R|AP000662.4_ENST00000530595.1_RNA			Q96NS1	YPEL4_HUMAN	yippee-like 4 (Drosophila)	90						nucleolus				lung(2)|skin(1)	3						GTGGTTTTGCAGCTCTCACAG	0.557													16	25					0	0	1	0	0	G	57413796	A	G	57413796	3	3	23	1	0	0	0	0	1	0	0	0	17551	188	7	4	123	4	YPEL4	11	57413796	Missense_Mutation	SNP	A	TCGA-N7-A4Y8-01A-11D-A28R-08	7410047	57413796	77592720	55	2398										
SCYL1	57410	broad.mit.edu	37	chr11	65302778	65302778	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cactttgcacggctacaggcCaaggatgaacagggccccat	11	13	0	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr11:65302778C>T	ENST00000524944.1	+	10	1344	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	SCYL1_ENST00000270176.5_Silent_p.A437A|SCYL1_ENST00000525364.1_Silent_p.A437A|SCYL1_ENST00000533862.1_Silent_p.A437A|SCYL1_ENST00000279270.6_Silent_p.A437A|SCYL1_ENST00000420247.2_Silent_p.A437A|SCYL1_ENST00000527630.1_Silent_p.A437A|SCYL1_ENST00000527009.1_Silent_p.A294A			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	437					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						GGCTACAGGCCAAGGATGAAC	0.577													58	255					0	0	1	0	0	T	65302778	C	T	65302778	2	4	23	1	0	0	0	0	0	0	0	1	14000	581	21	3		3	SCYL1	11	65302778	Silent	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	7888982	65302778	69703738	56	2399										
MOGAT2	80168	broad.mit.edu	37	chr11	75438615	75438615	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cttcgatcttccccggtatcCgcccccatctgatgatgctg	8	16	2	2	rs142019515	byFrequency	TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr11:75438615C>T	ENST00000526712.1	+	2	933	c.160C>T	c.(160-162)Cgc>Tgc	p.R54C	MOGAT2_ENST00000198801.5_Missense_Mutation_p.R136C			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	136					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CCCCGGTATCCGCCCCCATCT	0.572													148	58					0	0	1	0	0	T	75438615	C	T	75438615	3	4	23	1	0	0	0	0	1	0	0	0	9743	652	23	1	416	1	MOGAT2	11	75438615	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	10135837	75438615	59567901	57	2400										
IFFO1	25900	broad.mit.edu	37	chr12	6664977	6664977	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	agggtcttgagcacgttgatGttggagcccaggtcattgcg	15	8	2	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr12:6664977G>A	ENST00000336604.4	-	1	260	c.219C>T	c.(217-219)aaC>aaT	p.N73N	IFFO1_ENST00000396840.2_Silent_p.N73N|IFFO1_ENST00000356896.4_Silent_p.N73N	NM_080730.4	NP_542768.2	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan 1	73						intermediate filament		p.N73K(1)		central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						GCACGTTGATGTTGGAGCCCA	0.706													14	63					0	0	1	0	0	A	6664977	G	A	6664977	2	1	23	1	0	0	0	0	0	0	0	1	7553	1368	48	3		3	IFFO1	12	6664977	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		6664977	127186918	58	2401										
GPRC5D	55507	broad.mit.edu	37	chr12	13103268	13103268	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	atgccccatggcccctcggcGtcacagagaagaaaatagtc	10	13	1	2			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr12:13103268G>A	ENST00000228887.1	-	1	50	c.51C>T	c.(49-51)gaC>gaT	p.D17D	GPRC5D_ENST00000396333.3_Silent_p.D17D|RP11-392P7.6_ENST00000536029.1_RNA|RP11-392P7.6_ENST00000542078.1_RNA|RP11-392P7.6_ENST00000545914.1_RNA|RP11-392P7.6_ENST00000394742.3_RNA|RP11-392P7.6_ENST00000540198.1_RNA|RP11-392P7.6_ENST00000543515.2_RNA	NM_018654.1	NP_061124.1	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5, member D	17						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(2)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GCCCCTCGGCGTCACAGAGAA	0.507													33	95					0	0	1	0	0	A	13103268	G	A	13103268	2	1	23	1	0	0	0	0	0	0	0	1	6767	1136	40	1		1	GPRC5D	12	13103268	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	6438291	13103268	120748627	59	2402										
ERGIC2	51290	broad.mit.edu	37	chr12	29494102	29494102	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ggaggtgttaatgtgtattaTtttctaaaagaggtaagtgg	13	1	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr12:29494102T>C	ENST00000360150.4	-	14	1196	c.1121A>G	c.(1120-1122)aAt>aGt	p.N374S		NM_016570.2	NP_057654.2	Q96RQ1	ERGI2_HUMAN	ERGIC and golgi 2	374				N -> S (in Ref. 4; BAD96519).	vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)	ATGTGTATTATTTTCTAAAAG	0.318													3	12					0	0	1	0	0	C	29494102	T	C	29494102	3	2	23	1	0	0	0	0	1	0	0	0	5252	1493	52	4	16	4	ERGIC2	12	29494102	Missense_Mutation	SNP	T	TCGA-N7-A4Y8-01A-11D-A28R-08	16390834	29494102	104357793	60	2403										
OVCH1	341350	broad.mit.edu	37	chr12	29624754	29624754	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	caattgcacacagtgggctgCggtcagaatccacactgggt	12	11	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr12:29624754C>T	ENST00000318184.5	-	16	1836	c.1837G>A	c.(1837-1839)Gca>Aca	p.A613T	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	613	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CAGTGGGCTGCGGTCAGAATC	0.493													4	25					0	0	1	0	0	T	29624754	C	T	29624754	3	4	23	1	0	0	0	0	1	0	0	0	11369	768	27	1	1619	1	OVCH1	12	29624754	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08	130652	29624754	104227141	61	2404										
ERBB3	2065	broad.mit.edu	37	chr12	56482341	56482341	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	ccctagataactttgtggtgGatcaaacatcctgtgtcagg	10	9	2	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr12:56482341G>T	ENST00000267101.3	+	8	1329	c.889G>T	c.(889-891)Gat>Tat	p.D297Y	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.D238Y	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	297					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.D297Y(1)		central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTTTGTGGTGGATCAAACATC	0.512													76	191					5.94106e-25	6.7683e-25	1	1	0	T	56482341	G	T	56482341	3	4	23	1	0	0	0	0	1	0	0	0	5236	1174	41	2	1050	2	ERBB3	12	56482341	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	26857587	56482341	77369554	62	2405										
ACADS	35	broad.mit.edu	37	chr12	121174898	121174898	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cgccatggaggagatcagccGtggctgcgcctccaccggag	15	14	1	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr12:121174898G>A	ENST00000242592.4	+	3	471	c.320G>A	c.(319-321)cGt>cAt	p.R107H	ACADS_ENST00000411593.2_Missense_Mutation_p.R107H	NM_000017.2	NP_000008.1	P16219	ACADS_HUMAN	acyl-CoA dehydrogenase, C-2 to C-3 short chain	107			R -> C (in ACADSD).			mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	GAGATCAGCCGTGGCTGCGCC	0.672													3	1					0	0	1	0	0	A	121174898	G	A	121174898	3	1	23	1	0	0	0	0	1	0	0	0	114	1145	40	1	330	1	ACADS	12	121174898	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08	64692557	121174898	12676997	63	2406										
SLC15A1	6564	broad.mit.edu	37	chr13	99362129	99362129	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	agtcaaacttacgattttccCggacatagttgttgcctgca	8	10	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr13:99362129C>T	ENST00000376503.5	-	12	992	c.937G>A	c.(937-939)Ggg>Agg	p.G313R		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	313					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	ACGATTTTCCCGGACATAGTT	0.368													42	65					0	0	1	0	0	T	99362129	C	T	99362129	3	4	23	1	0	0	0	0	1	0	0	0	14452	652	23	1	1237	1	SLC15A1	13	99362129	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		99362129	15807749	64	2407										
FAM161B	145483	broad.mit.edu	37	chr14	74407730	74407730	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	agagaacgactccttggcagGggtgtagctggtggctgtgg	18	7	0	1			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr14:74407730G>A	ENST00000286544.3	-	5	1686	c.1488C>T	c.(1486-1488)ccC>ccT	p.P496P	FAM161B_ENST00000534936.1_Silent_p.P433P	NM_152445.2	NP_689658.2			family with sequence similarity 161, member B											breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)	21						TCCTTGGCAGGGGTGTAGCTG	0.478													24	73					0	0	1	0	0	A	74407730	G	A	74407730	2	1	23	1	0	0	0	0	0	0	0	1	5503	1219	43	3		3	FAM161B	14	74407730	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		74407730	32941810	65	2408										
ITPKA	3706	broad.mit.edu	37	chr15	41794651	41794651	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	agactacgcgaagccgagagCaggtgcttcgcgtctttgaa	13	10	1	3			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr15:41794651C>G	ENST00000260386.5	+	5	1113	c.1060C>G	c.(1060-1062)Cag>Gag	p.Q354E		NM_002220.2	NP_002211.1	P23677	IP3KA_HUMAN	inositol-trisphosphate 3-kinase A	354					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			kidney(1)|lung(3)|skin(1)	5		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		AAGCCGAGAGCAGGTGCTTCG	0.617													28	43					0	0	1	0	0	G	41794651	C	G	41794651	3	3	23	1	0	0	0	0	1	0	0	0	7960	711	25	5	1078	5	ITPKA	15	41794651	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		41794651	60736741	66	2409										
NOMO1	23420	broad.mit.edu	37	chr16	14980689	14980689	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cttggccagtccctgttcttCcatttccccccactgctcag	6	18	2	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr16:14980689C>T	ENST00000287667.7	+	28	3465	c.3294C>T	c.(3292-3294)ttC>ttT	p.F1098F		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1098						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						CCCTGTTCTTCCATTTCCCCC	0.473													37	64					0	0	1	0	0	T	14980689	C	T	14980689	2	4	23	1	0	0	0	0	0	0	0	1	10577	854	30	3		3	NOMO1	16	14980689	Silent	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		14980689	75374064	67	2410										
C17orf97	400566	broad.mit.edu	37	chr17	263136	263136	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	accttgcgaatcggatcaacGaaagtctgcgttgggatgga	13	8	2	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr17:263136G>A	ENST00000360127.6	+	2	518	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	C17orf97_ENST00000571106.1_Intron|AC108004.3_ENST00000466740.2_RNA	NM_001013672.4	NP_001013694.4	Q6ZQX7	CQ097_HUMAN	chromosome 17 open reading frame 97	168										breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	14						TCGGATCAACGAAAGTCTGCG	0.517													81	34					0	0	1	0	0	A	263136	G	A	263136	3	1	23	1	0	0	0	0	1	0	0	0	1903	1059	37	1		1	C17orf97	17	263136	Missense_Mutation	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		263136	80932074	68	2411										
TP53	7157	broad.mit.edu	37	chr17	7577565	7577565	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	tgccgcccatgcaggaactgTtacacatgtagttgtagtgg	12	9	0	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr17:7577565T>C	ENST00000420246.2	-	7	848	c.716A>G	c.(715-717)aAc>aGc	p.N239S	TP53_ENST00000269305.4_Missense_Mutation_p.N239S|TP53_ENST00000359597.4_Missense_Mutation_p.N239S|TP53_ENST00000413465.2_Missense_Mutation_p.N239S|TP53_ENST00000445888.2_Missense_Mutation_p.N239S|TP53_ENST00000455263.2_Missense_Mutation_p.N239S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	239	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		N -> D (in sporadic cancers; somatic mutation).|N -> H (in a sporadic cancer; somatic mutation).|N -> I (in a sporadic cancer; somatic mutation).|N -> K (in sporadic cancers; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> T (in sporadic cancers; somatic mutation).|N -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N239S(28)|p.0?(8)|p.?(5)|p.N239T(4)|p.M237_N239delMCN(4)|p.N146S(3)|p.N239_C242delNSSC(3)|p.N239fs*25(2)|p.N239_S240delNS(2)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*1(1)|p.N239_S240insN(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.M144_N146delMCN(1)|p.C238fs*21(1)|p.N239I(1)|p.H233fs*6(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.N239fs*>48(1)|p.N146fs*>10(1)|p.N239_C242del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGAACTGTTACACATGTA	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			59	4					0	0	1	0	0	C	7577565	T	C	7577565	3	2	23	1	0	0	0	0	1	0	0	0	16441	1725	60	4	574	4	TP53	17	7577565	Missense_Mutation	SNP	T	TCGA-N7-A4Y8-01A-11D-A28R-08	7314429	7577565	73617645	69	2412										
CRLF1	9244	broad.mit.edu	37	chr19	18707437	18707437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	taggagggtgctcaccactgCggggagtggaggcggctgtg	20	8	1	0			TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr19:18707437C>T	ENST00000392386.3	-	6	1212	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	340					negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						CTCACCACTGCGGGGAGTGGA	0.552													13	32					0	0	1	0	0	T	18707437	C	T	18707437	3	4	23	1	0	0	0	0	1	0	0	0	3909	768	27	1	265	1	CRLF1	19	18707437	Missense_Mutation	SNP	C	TCGA-N7-A4Y8-01A-11D-A28R-08		18707437	40421546	70	2413										
BAGE2	85319	broad.mit.edu	37	chr21	11051168	11051168	+	RNA	DEL	T	T	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	acaaaaagtcagaccttttgTttttatttacactcttttaa					rs59377780		TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr21:11051168delT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agaccttttgtttttatttac	0.393													3	5	---	---	---	---						-	11051168	T	-	11051168	6	5	23	0	1	1	0	1	0	0	0	0	1290	1740	60	0		0	BAGE2	21	11051168	RNA	DEL	T	TCGA-N7-A4Y8-01A-11D-A28R-08		11051168	37078727	71	2414										
BAGE2	85319	broad.mit.edu	37	chr21	11055621	11055621	+	RNA	DEL	A	A	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	atttaagacagtatcattttAaaagcataaaaagtaacttc							TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr21:11055621delA	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gtatcattTTAAAAGCATAAA	0.274													4	4	---	---	---	---						-	11055621	A	-	11055621	6	5	23	0	1	1	0	1	0	0	0	0	1290	377	13	0		0	BAGE2	21	11055621	RNA	DEL	A	TCGA-N7-A4Y8-01A-11D-A28R-08	4453	11055621	37074274	72	2415										
PLXNB2	23654	broad.mit.edu	37	chr22	50719352	50719360	+	In_Frame_Del	DEL	TGCCGGCCT	TGCCGGCCT	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	cttgtagtccagcacggggaTgccggcctcgtgcacgtcgt							TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chr22:50719352_50719360delTGCCGGCCT	ENST00000449103.1	-	24	3946_3954	c.3806_3814delAGGCCGGCA	c.(3805-3816)gtc>g	p.EAGI1269del	PLXNB2_ENST00000359337.4_In_Frame_Del_p.EAGI1269del			O15031	PLXB2_HUMAN	plexin B2	1269					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGCACGGGGATGCCGGCCTCGTGCACGTC	0.646													24	5	---	---	---	---						-	50719360	TGCCGGCCT	-	50719352	7	5	23	1	0	1	0	1	0	0	0	0	12171	1464	51	0	1758	0	PLXNB2	22	50719352	In_Frame_Del	DEL	TGCCGGCCT	TCGA-N7-A4Y8-01A-11D-A28R-08		50719352	585214	73	2416										
NUDT10	170685	broad.mit.edu	37	chrX	51076024	51076024	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	gtccgagaggtgtacgaagaGgcgggagtcaaggggaagtt	19	5	1	2	rs143435240	byFrequency	TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657													3	38					0	0	1	0	0	A	51076024	G	A	51076024	2	1	23	1	0	0	0	0	0	0	0	1	10773	991	35	3		3	NUDT10	23	51076024	Silent	SNP	G	TCGA-N7-A4Y8-01A-11D-A28R-08		51076024	104194536	74	2417										
HTATSF1	27336	broad.mit.edu	37	chrX	135585048	135585050	+	In_Frame_Del	DEL	AAG	AAG	-													0.0405405405405405	3	1	0.677465918203689	0	0.766606170598911	0.142857142857143	0.651583710407241	0	agggagaatatgatgcctcaAagaagaagaagaagtgcaaa							TCGA-N7-A4Y8-01A-11D-A28R-08	TCGA-N7-A4Y8-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7a243088-bff7-435b-9f10-ddede7b3113f	7ca039c3-049f-4f57-999d-68d6bd34060f	g.chrX:135585048_135585050delAAG	ENST00000535601.1	+	6	1104_1106	c.682_684delAAG	c.(682-684)del	p.K232del	HTATSF1_ENST00000218364.4_In_Frame_Del_p.K232del	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	232	Poly-Lys.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					TGATGCCTCAAAGAAGAAGAAGA	0.335													7	90	---	---	---	---						-	135585050	AAG	-	135585048	7	5	23	1	0	1	0	1	0	0	0	0	7476	15	1	0	700	0	HTATSF1	23	135585048	In_Frame_Del	DEL	AAG	TCGA-N7-A4Y8-01A-11D-A28R-08	84509024	135585048	19685512	75	2418										
USP1	7398	broad.mit.edu	37	chr1	62908931	62908931	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	caggctagttttctcttaaaTccagagaaatatactgatga	7	7	1	3			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:62908931T>A	ENST00000339950.4	+	5	1313	c.498T>A	c.(496-498)aaT>aaA	p.N166K	USP1_ENST00000371146.1_Missense_Mutation_p.N166K	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1	166					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		TTCTCTTAAATCCAGAGAAAT	0.368													30	37					0	0	1	0	0	A	62908931	T	A	62908931	3	1	24	1	0	0	0	0	1	0	0	0	17099	1432	50	4	512	4	USP1	1	62908931	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08		62908931	186341690	1	2419										
USP1	7398	broad.mit.edu	37	chr1	62910418	62910418	+	Frame_Shift_Del	DEL	C	C	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tttatttatagggaactcaaCcctatgtatgaaggatatct							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:62910418delC	ENST00000339950.4	+	6	1382	c.567delC	c.(565-567)aafs	p.N189fs	USP1_ENST00000371146.1_Frame_Shift_Del_p.N189fs	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1	189					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		GGGAACTCAACCCTATGTATG	0.303													27	39	---	---	---	---						-	62910418	C	-	62910418	7	5	24	1	0	1	0	1	0	0	0	0	17099	506	18	0	585	0	USP1	1	62910418	Frame_Shift_Del	DEL	C	TCGA-N7-A59B-01A-11D-A28R-08	1487	62910418	186340203	2	2420										
ASPM	259266	broad.mit.edu	37	chr1	197071386	197071386	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tagcagccctgtgcatctctCgcatccttttccttatcatc	5	15	2	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:197071386C>A	ENST00000367409.4	-	18	7251	c.6995G>T	c.(6994-6996)cGa>cTa	p.R2332L	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	2332	IQ 22.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						GTGCATCTCTCGCATCCTTTT	0.403													40	44					5.43694e-19	6.37434e-19	1	1	0	A	197071386	C	A	197071386	3	1	24	1	0	0	0	0	1	0	0	0	1055	884	31	2	3482	2	ASPM	1	197071386	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	134160968	197071386	52179235	3	2421										
C1orf106	55765	broad.mit.edu	37	chr1	200881172	200881172	+	Frame_Shift_Del	DEL	C	C	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gcacgcctccggagcacccgCccccactcactggaccgcca					rs296521	by1000genomes	TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:200881172delC	ENST00000367342.4	+	9	2006	c.1806delC	c.(1804-1806)cgfs	p.R602fs	C1orf106_ENST00000413687.2_Frame_Shift_Del_p.R517fs|C1orf106_ENST00000465162.1_3'UTR	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	602										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GGAGCACCCGCCCCCACTCAC	0.716													2	4	---	---	---	---						-	200881172	C	-	200881172	7	5	24	1	0	1	0	1	0	0	0	0	1993	726	26	0	1840	0	C1orf106	1	200881172	Frame_Shift_Del	DEL	C	TCGA-N7-A59B-01A-11D-A28R-08	3809786	200881172	48369449	4	2422										
MYT1L	23040	broad.mit.edu	37	chr2	1946857	1946859	+	In_Frame_Del	DEL	CTC	CTC	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tcctcatcctcctcctcgatCtcctcctcctcctcccggtc							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:1946857_1946859delCTC	ENST00000399161.2	-	9	1147_1149	c.400_402delGAG	c.(400-402)del	p.E134del	MYT1L_ENST00000428368.2_In_Frame_Del_p.E134del	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	134	Asp/Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		cctcctcgatctcctcctcctcc	0.576													4	4	---	---	---	---						-	1946859	CTC	-	1946857	7	5	24	1	0	1	0	1	0	0	0	0	10154	912	32	0	3220	0	MYT1L	2	1946857	In_Frame_Del	DEL	CTC	TCGA-N7-A59B-01A-11D-A28R-08		1946857	241252516	5	2423										
ROCK2	9475	broad.mit.edu	37	chr2	11426743	11426743	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gccttcatctgtagacctctGatttttttcacaattttctc	4	11	5	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:11426743G>C	ENST00000315872.6	-	3	694	c.246C>G	c.(244-246)atC>atG	p.I82M	ROCK2_ENST00000462366.1_5'UTR	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	82					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTAGACCTCTGATTTTTTTCA	0.279													42	196					0	0	1	0	0	C	11426743	G	C	11426743	3	2	24	1	0	0	0	0	1	0	0	0	13569	1280	45	2	4044	2	ROCK2	2	11426743	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	9479886	11426743	231772630	6	2424										
TTC27	55622	broad.mit.edu	37	chr2	33036105	33036105	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tttaaggtccttaaaattctAgtcagggcagtgattgatgg	11	5	2	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:33036105A>T	ENST00000317907.4	+	17	2244	c.2013A>T	c.(2011-2013)ctA>ctT	p.L671L		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	671							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						TTAAAATTCTAGTCAGGGCAG	0.403													34	80					0	0	1	0	0	T	33036105	A	T	33036105	2	4	24	1	0	0	0	0	0	0	0	1	16756	407	15	4		4	TTC27	2	33036105	Silent	SNP	A	TCGA-N7-A59B-01A-11D-A28R-08	21609362	33036105	210163268	7	2425										
GPR45	11250	broad.mit.edu	37	chr2	105859066	105859066	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cgggcctgcggcgcctgcagCggcagcaacaggtcagcgtg	17	14	1	0	rs112504064		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:105859066C>T	ENST00000258456.1	+	1	867	c.751C>T	c.(751-753)Cgg>Tgg	p.R251W		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	251						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						GCGCCTGCAGCGGCAGCAACA	0.652													82	77					0	0	1	0	0	T	105859066	C	T	105859066	3	4	24	1	0	0	0	0	1	0	0	0	6735	759	27	1	753	1	GPR45	2	105859066	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	72822961	105859066	137340307	8	2426										
DZIP3	9666	broad.mit.edu	37	chr3	108373036	108373036	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gcagttgaggaaagaacaagCaaatccacactcagtcagta	9	9	2	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr3:108373036C>A	ENST00000361582.3	+	19	2308	c.2078C>A	c.(2077-2079)gCa>gAa	p.A693E	DZIP3_ENST00000463306.1_Missense_Mutation_p.A693E	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	693					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						AAAGAACAAGCAAATCCACAC	0.373													36	59					6.05902e-23	7.2283e-23	1	1	0	A	108373036	C	A	108373036	3	1	24	1	0	0	0	0	1	0	0	0	4891	710	25	5	2148	5	DZIP3	3	108373036	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08		108373036	89649394	9	2427										
PIK3CA	5290	broad.mit.edu	37	chr3	178916930	178916930	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	aaaagtaattgaaccagtagGcaaccgtgaagaaaagatcc	9	7	0	4			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr3:178916930G>T	ENST00000263967.3	+	2	474	c.317G>T	c.(316-318)gGc>gTc	p.G106V		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	106	PI3K-ABD.		G -> V (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G106V(6)|p.G106_R108delGNR(2)|p.G106_R108del(2)|p.G106A(1)|p.E103_G106>D(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAACCAGTAGGCAACCGTGAA	0.348		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			102	38					3.37413e-40	4.09715e-40	1	1	0	T	178916930	G	T	178916930	3	4	24	1	0	0	0	0	1	0	0	0	11960	1203	42	5	319	5	PIK3CA	3	178916930	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	70543894	178916930	19105500	10	2428										
NPM1	4869	broad.mit.edu	37	chr5	170819814	170819814	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cctggaggtggtagcaaggtTccacaggtagagatggcaat	15	7	0	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr5:170819814T>A	ENST00000296930.5	+	5	754	c.453T>A	c.(451-453)gtT>gtA	p.V151V	NPM1_ENST00000393820.2_Silent_p.V151V|NPM1_ENST00000351986.6_Silent_p.V151V|NPM1_ENST00000517671.1_Silent_p.V151V	NM_002520.6	NP_002511.1	P06748	NPM_HUMAN	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	151	Required for interaction with SENP3.				anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4261)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	4269	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTAGCAAGGTTCCACAGGTAG	0.408			"T, F "	"ALK, RARA, MLF1"	"NHL, APL, AML"								37	64					0	0	1	0	0	A	170819814	T	A	170819814	2	1	24	1	0	0	0	0	0	0	0	1	10634	1770	62	4		4	NPM1	5	170819814	Silent	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08		170819814	10095446	11	2429										
BTN3A3	10384	broad.mit.edu	37	chr6	26448652	26448652	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	aagaaatgggatacgctgcaAcagagcaagaaataagccta	10	7	0	3			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr6:26448652A>G	ENST00000244519.2	+	6	1135	c.892A>G	c.(892-894)Aca>Gca	p.T298A	BTN3A3_ENST00000339789.4_Missense_Mutation_p.T256A|BTN3A3_ENST00000361232.3_Missense_Mutation_p.T256A	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	298						integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						ATACGCTGCAACAGAGCAAGA	0.498													23	39					0	0	1	0	0	G	26448652	A	G	26448652	3	3	24	1	0	0	0	0	1	0	0	0	1567	43	2	4	906	4	BTN3A3	6	26448652	Missense_Mutation	SNP	A	TCGA-N7-A59B-01A-11D-A28R-08		26448652	144666415	12	2430										
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333707	28333707	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tgaacatcacagaatccacaCtggggagaagccgtatcagt	10	10	2	3			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr6:28333707C>A	ENST00000377255.3	+	7	1559	c.1262C>A	c.(1261-1263)aCt>aAt	p.T421N	ZKSCAN3_ENST00000341464.5_Missense_Mutation_p.T273N|ZKSCAN3_ENST00000252211.2_Missense_Mutation_p.T421N	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	421					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						AGAATCCACACTGGGGAGAAG	0.502													34	21					8.16721e-17	9.41305e-17	1	1	0	A	28333707	C	A	28333707	3	1	24	1	0	0	0	0	1	0	0	0	17745	565	20	5	1280	5	ZKSCAN3	6	28333707	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	1885055	28333707	142781360	13	2431										
SNRPC	6631	broad.mit.edu	37	chr6	34725706	34725706	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	caggttttattgtgactactGcgatacatacctcacccatg	7	11	1	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr6:34725706G>A	ENST00000374017.3	+	1	376	c.89G>A	c.(88-90)tGc>tAc	p.C30Y	SNRPC_ENST00000244520.5_Missense_Mutation_p.C9Y|SNRPC_ENST00000374018.1_Intron|SNRPC_ENST00000474635.1_3'UTR			P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	9					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)	6						TGTGACTACTGCGATACATAC	0.368													20	40					0	0	1	0	0	A	34725706	G	A	34725706	3	1	24	1	0	0	0	0	1	0	0	0	14916	1319	46	3	32	3	SNRPC	6	34725706	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	6391999	34725706	136389361	14	2432										
CREB5	9586	broad.mit.edu	37	chr7	28610154	28610154	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cttccaccaaccgccagatcGggtaaggagccctccttggc	10	16	0	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:28610154G>C	ENST00000357727.2	+	5	853	c.464_splice	c.e5+1	p.G155_splice	CREB5_ENST00000409603.1_Splice_Site_p.G122_splice|CREB5_ENST00000396299.2_Splice_Site_p.G122_splice|CREB5_ENST00000396300.2_Splice_Site_p.G148_splice	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	155					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CCGCCAGATCGGGTAAGGAGC	0.572													40	22					0	0	1	0	0	C	28610154	G	C	28610154	5	2	24	1	0	0	0	0	0	0	1	0	3883	1130	39	5	481	5	CREB5	7	28610154	Splice_Site	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08		28610154	130528509	15	2433										
C7orf43	55262	broad.mit.edu	37	chr7	99755809	99755809	+	Frame_Shift_Del	DEL	G	G	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ccccaggatcccctccccctGggggctccgaatcctggtcg							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:99755809delG	ENST00000316937.3	-	1	499	c.314delC	c.(313-315)cafs	p.P105fs		NM_018275.3	NP_060745.3	Q8WVR3	CG043_HUMAN	chromosome 7 open reading frame 43	105	Gly-rich.									breast(1)|endometrium(3)|large_intestine(3)|lung(2)|prostate(1)	10	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCTCCCCCTGGGGGCTCCGA	0.756													2	4	---	---	---	---						-	99755809	G	-	99755809	7	5	24	1	0	1	0	1	0	0	0	0	2409	1348	47	0	1472	0	C7orf43	7	99755809	Frame_Shift_Del	DEL	G	TCGA-N7-A59B-01A-11D-A28R-08	71145655	99755809	59382854	16	2434										
TBXAS1	6916	broad.mit.edu	37	chr7	139715631	139715631	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	caccatgaccctgagcactgGccaagcccggagaccttcaa	9	16	1	3			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:139715631G>A	ENST00000263552.6	+	15	1876	c.1338G>A	c.(1336-1338)tgG>tgA	p.W446*	TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000416849.2_Nonsense_Mutation_p.W492*|TBXAS1_ENST00000425687.1_Nonsense_Mutation_p.W378*|TBXAS1_ENST00000458722.1_Nonsense_Mutation_p.W491*|TBXAS1_ENST00000448866.1_Nonsense_Mutation_p.W445*|TBXAS1_ENST00000336425.5_Nonsense_Mutation_p.W445*|TBXAS1_ENST00000414508.2_Nonsense_Mutation_p.W446*|TBXAS1_ENST00000411653.1_Nonsense_Mutation_p.W445*|TBXAS1_ENST00000436047.2_Nonsense_Mutation_p.W446*	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	445					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CTGAGCACTGGCCAAGCCCGG	0.597													19	43					0	0	1	0	0	A	139715631	G	A	139715631	4	1	24	1	0	0	0	0	0	1	0	0	15723	1212	42	3	1522	3	TBXAS1	7	139715631	Nonsense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	39959822	139715631	19423032	17	2435										
MGAM	8972	broad.mit.edu	37	chr7	141756660	141756660	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ccagcccctgcctgccttgaCataccgcaccacagggggag	11	17	0	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:141756660C>T	ENST00000475668.2	+	30	3665	c.3611C>T	c.(3610-3612)aCa>aTa	p.T1204I	MGAM_ENST00000549489.2_Missense_Mutation_p.T1204I			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1204	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTGCCTTGACATACCGCACC	0.517													9	28					0	0	1	0	0	T	141756660	C	T	141756660	3	4	24	1	0	0	0	0	1	0	0	0	9590	478	17	3	3725	3	MGAM	7	141756660	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	2041029	141756660	17382003	18	2436										
KCNH2	3757	broad.mit.edu	37	chr7	150648140	150648140	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cagcatctgtgtgtggtagcGggctgtgcccgagtacagcc	15	11	1	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:150648140G>A	ENST00000392968.2	-	6	2846	c.1726C>T	c.(1726-1728)Cgc>Tgc	p.R576C	KCNH2_ENST00000262186.5_Missense_Mutation_p.R672C|KCNH2_ENST00000330883.4_Missense_Mutation_p.R332C|KCNH2_ENST00000430723.3_Missense_Mutation_p.R672C			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	672					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GTGTGGTAGCGGGCTGTGCCC	0.652													18	35					0	0	1	0	0	A	150648140	G	A	150648140	3	1	24	1	0	0	0	0	1	0	0	0	8075	1116	39	1	1766	1	KCNH2	7	150648140	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	8891480	150648140	8490523	19	2437										
HTRA4	203100	broad.mit.edu	37	chr8	38834215	38834215	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tgaagctgttgtcaaggataTtgaccttaaattggatcttg	10	5	2	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr8:38834215T>C	ENST00000302495.4	+	3	828	c.728T>C	c.(727-729)aTt>aCt	p.I243T		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	243	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GTCAAGGATATTGACCTTAAA	0.433													21	25					0	0	1	0	0	C	38834215	T	C	38834215	3	2	24	1	0	0	0	0	1	0	0	0	7499	1493	52	4	738	4	HTRA4	8	38834215	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08		38834215	107529807	20	2438										
FER1L6	654463	broad.mit.edu	37	chr8	125082754	125082754	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	attcaacaattttgaagactGggtgaaaacttttgagctct	8	6	2	4			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr8:125082754G>A	ENST00000522917.1	+	30	4087	c.3881G>A	c.(3880-3882)tGg>tAg	p.W1294*	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Nonsense_Mutation_p.W1294*	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1294						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TTTGAAGACTGGGTGAAAACT	0.418													16	88					0	0	1	0	0	A	125082754	G	A	125082754	4	1	24	1	0	0	0	0	0	1	0	0	5847	1357	47	3	3995	3	FER1L6	8	125082754	Nonsense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	86248539	125082754	21281268	21	2439										
UNC13B	10497	broad.mit.edu	37	chr9	35381192	35381192	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	aagtagccccataccacgtgCagtatacatgtctccatgag	8	12	1	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr9:35381192C>T	ENST00000378495.3	+	18	2446	c.2224C>T	c.(2224-2226)Cag>Tag	p.Q742*	UNC13B_ENST00000396787.1_Nonsense_Mutation_p.Q754*|UNC13B_ENST00000378496.4_Nonsense_Mutation_p.Q742*	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	742					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ATACCACGTGCAGTATACATG	0.537													18	31					0	0	1	0	0	T	35381192	C	T	35381192	4	4	24	1	0	0	0	0	0	1	0	0	17044	711	25	3	2294	3	UNC13B	9	35381192	Nonsense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08		35381192	105832239	22	2440										
OR13C8	138802	broad.mit.edu	37	chr9	107331463	107331463	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tgtaatatggaaaggaccaaCgattccacgtcgacagaatt	9	8	0	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr9:107331463C>T	ENST00000335040.1	+	1	15	c.15C>T	c.(13-15)aaC>aaT	p.N5N		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						AAAGGACCAACGATTCCACGT	0.408													50	5					0	0	1	0	0	T	107331463	C	T	107331463	2	4	24	1	0	0	0	0	0	0	0	1	10985	535	19	1		1	OR13C8	9	107331463	Silent	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	71950271	107331463	33881968	23	2441										
SORCS3	22986	broad.mit.edu	37	chr10	107015549	107015549	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gtcattgtgtatgtcacacaGctgacgttaggtgagtgcca	12	8	2	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr10:107015549G>A	ENST00000369701.3	+	24	3554	c.3327G>A	c.(3325-3327)caG>caA	p.Q1109Q		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1109						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATGTCACACAGCTGACGTTAG	0.443													27	34					0	0	1	0	0	A	107015549	G	A	107015549	2	1	24	1	0	0	0	0	0	0	0	1	14985	962	34	3		3	SORCS3	10	107015549	Silent	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08		107015549	28519198	24	2442										
C10orf137	26098	broad.mit.edu	37	chr10	127414264	127414266	+	In_Frame_Del	DEL	GGA	GGA	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tggccagtatcaatggtgatGgagccgctcagcctgtctca							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr10:127414264_127414266delGGA	ENST00000337623.3	+	6	754_756	c.649_651delGGA	c.(649-651)del	p.G217del	C10orf137_ENST00000356792.4_In_Frame_Del_p.G217del	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CAATGGTGATGGAGCCGCTCAGC	0.448													21	31	---	---	---	---						-	127414266	GGA	-	127414264	7	5	24	1	0	1	0	1	0	0	0	0	1598	1349	47	0	671	0	C10orf137	10	127414264	In_Frame_Del	DEL	GGA	TCGA-N7-A59B-01A-11D-A28R-08	20398715	127414264	8120483	25	2443										
PHRF1	57661	broad.mit.edu	37	chr11	587405	587405	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cattcagagaccaggccgtgGggacgccggagaactgtgcc	15	12	1	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr11:587405G>C	ENST00000264555.5	+	4	489	c.361G>C	c.(361-363)Ggg>Cgg	p.G121R	PHRF1_ENST00000416188.2_Missense_Mutation_p.G121R|PHRF1_ENST00000533464.1_Missense_Mutation_p.G117R|PHRF1_ENST00000413872.2_Missense_Mutation_p.G120R	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	121							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CCAGGCCGTGGGGACGCCGGA	0.552													16	54					0	0	1	0	0	C	587405	G	C	587405	3	2	24	1	0	0	0	0	1	0	0	0	11908	1232	43	5	371	5	PHRF1	11	587405	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08		587405	134419111	26	2444										
SLC15A3	51296	broad.mit.edu	37	chr11	60707095	60707095	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ggtggatgtagtgtaagcgcTccatctccaggactcctggt	13	10	1	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr11:60707095T>A	ENST00000227880.3	-	6	1525	c.1292A>T	c.(1291-1293)gAg>gTg	p.E431V		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	431					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GTGTAAGCGCTCCATCTCCAG	0.592													14	30					0	0	1	0	0	A	60707095	T	A	60707095	3	1	24	1	0	0	0	0	1	0	0	0	14454	1551	54	4	465	4	SLC15A3	11	60707095	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08	60119690	60707095	74299421	27	2445										
RNF113B	140432	broad.mit.edu	37	chr13	98829047	98829047	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ctcaggtagctgtggattccCcggtagatgtggtcgtgctc	14	10	1	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr13:98829047C>T	ENST00000267291.6	-	1	472	c.444G>A	c.(442-444)cgG>cgA	p.R148R	FARP1_ENST00000595437.1_Intron|FARP1_ENST00000319562.6_Intron|FARP1_ENST00000376581.5_Intron|FARP1_ENST00000376586.2_Intron	NM_178861.4	NP_849192.1	Q8IZP6	R113B_HUMAN	ring finger protein 113B	148							nucleic acid binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			TGTGGATTCCCCGGTAGATGT	0.647													11	51					0	0	1	0	0	T	98829047	C	T	98829047	2	4	24	1	0	0	0	0	0	0	0	1	13479	610	22	3		3	RNF113B	13	98829047	Silent	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08		98829047	16340831	28	2446										
LIG4	3981	broad.mit.edu	37	chr13	108861426	108861426	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tggtacaaagcttttggtctTaaaacattctaaaagccatg	7	7	2	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr13:108861426T>C	ENST00000356922.4	-	2	2463	c.2191A>G	c.(2191-2193)Aag>Gag	p.K731E	LIG4_ENST00000405925.1_Missense_Mutation_p.K731E|LIG4_ENST00000442234.1_Missense_Mutation_p.K731E	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	731	BRCT 1.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CTTTTGGTCTTAAAACATTCT	0.383								Non-homologous end-joining					26	45					0	0	1	0	0	C	108861426	T	C	108861426	3	2	24	1	0	0	0	0	1	0	0	0	8822	1763	61	4	548	4	LIG4	13	108861426	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08	10032379	108861426	6308452	29	2447										
MYH7	4625	broad.mit.edu	37	chr14	23886383	23886383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ctgcaggtttttgttctcccGcttgaaggtctccagatgtt	10	10	2	2	rs45544633		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr14:23886383G>A	ENST00000355349.3	-	32	4660	c.4498C>T	c.(4498-4500)Cgg>Tgg	p.R1500W		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1500			R -> P (in MPD1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1500W(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTGTTCTCCCGCTTGAAGGTC	0.597													90	8					0	0	1	0	0	A	23886383	G	A	23886383	3	1	24	1	0	0	0	0	1	0	0	0	10086	1086	38	1	1345	1	MYH7	14	23886383	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08		23886383	83463157	30	2448										
USP10	9100	broad.mit.edu	37	chr16	84778803	84778803	+	Frame_Shift_Del	DEL	C	C	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cggcagtgacaccaggactgCagggcagccagaggggggcc							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr16:84778803delC	ENST00000219473.7	+	4	829	c.716delC	c.(715-717)gafs	p.A239fs	USP10_ENST00000570191.1_Frame_Shift_Del_p.A243fs|USP10_ENST00000562743.1_3'UTR	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	239					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						ACCAGGACTGCAGGGCAGCCA	0.627													19	3	---	---	---	---						-	84778803	C	-	84778803	7	5	24	1	0	1	0	1	0	0	0	0	17100	710	25	0	730	0	USP10	16	84778803	Frame_Shift_Del	DEL	C	TCGA-N7-A59B-01A-11D-A28R-08		84778803	5575950	31	2449										
TP53	7157	broad.mit.edu	37	chr17	7578479	7578479	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gacgcgggtgccgggcggggGtgtggaatcaacccacagct	18	11	1	0	rs28934874		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr17:7578479G>A	ENST00000420246.2	-	5	583	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	TP53_ENST00000359597.4_Missense_Mutation_p.P151S|TP53_ENST00000455263.2_Missense_Mutation_p.P151S|TP53_ENST00000413465.2_Missense_Mutation_p.P151S|TP53_ENST00000445888.2_Missense_Mutation_p.P151S|TP53_ENST00000269305.4_Missense_Mutation_p.P151S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	151	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(68)|p.P151T(16)|p.P151A(13)|p.P152fs*18(9)|p.0?(8)|p.T150fs*16(6)|p.P151fs*30(6)|p.?(5)|p.P58A(2)|p.P58S(2)|p.P19A(2)|p.P19S(2)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.T57fs*16(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.P58T(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.Q144fs*16(1)|p.P19T(1)|p.P152fs*14(1)|p.T18fs*16(1)|p.T150_P151delTP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	4					0	0	1	0	0	A	7578479	G	A	7578479	3	1	24	1	0	0	0	0	1	0	0	0	16441	1261	44	3	847	3	TP53	17	7578479	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08		7578479	73616731	32	2450										
UBB	7314	broad.mit.edu	37	chr17	16285416	16285416	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tacaacatccagaaggagtcGaccctgcacctggtcctgcg	10	14	0	1	rs146449749		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr17:16285416G>T	ENST00000302182.3	+	2	587	c.195G>T	c.(193-195)tcG>tcT	p.S65S	UBB_ENST00000578649.1_Intron|UBB_ENST00000395837.1_Silent_p.S65S|UBB_ENST00000535788.1_Silent_p.S65S|UBB_ENST00000395839.1_Silent_p.S65S	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	65	Ubiquitin-like 1.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGAAGGAGTCGACCCTGCACC	0.562													4	125					0.014758	0.0149783	1	1	0	T	16285416	G	T	16285416	2	4	24	1	0	0	0	0	0	0	0	1	16901	1045	37	2		2	UBB	17	16285416	Silent	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	8706937	16285416	64909794	33	2451										
TNRC6C	57690	broad.mit.edu	37	chr17	76045946	76045946	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	caattctgggttcagtcaggGgaatggagacactgtgaact	13	7	3	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr17:76045946G>A	ENST00000335749.4	+	3	1372	c.803G>A	c.(802-804)gGg>gAg	p.G268E	TNRC6C_ENST00000301624.4_Missense_Mutation_p.G268E|TNRC6C_ENST00000544502.1_Missense_Mutation_p.G268E|TNRC6C_ENST00000588061.1_Missense_Mutation_p.G268E|TNRC6C_ENST00000541771.1_Missense_Mutation_p.G268E|TNRC6C_ENST00000588847.1_Missense_Mutation_p.G268E	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	268	Gly-rich.|Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTCAGTCAGGGGAATGGAGAC	0.493													30	115					0	0	1	0	0	A	76045946	G	A	76045946	3	1	24	1	0	0	0	0	1	0	0	0	16401	1232	43	3	805	3	TNRC6C	17	76045946	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	59760530	76045946	5149264	34	2452										
FHOD3	80206	broad.mit.edu	37	chr18	34297864	34297864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cgacatcctcaccaacaaacGgttcatgcttgacatgctgt	7	13	2	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr18:34297864G>A	ENST00000257209.4	+	16	2200	c.2078G>A	c.(2077-2079)cGg>cAg	p.R693Q	FHOD3_ENST00000445677.1_Missense_Mutation_p.R655Q|FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000587493.1_3'UTR|FHOD3_ENST00000359247.4_Missense_Mutation_p.R676Q|FHOD3_ENST00000590592.1_Missense_Mutation_p.R868Q	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	676					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				ACCAACAAACGGTTCATGCTT	0.542													49	59					0	0	1	0	0	A	34297864	G	A	34297864	3	1	24	1	0	0	0	0	1	0	0	0	5915	1116	39	1	2140	1	FHOD3	18	34297864	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08		34297864	43779384	35	2453										
SAFB2	9667	broad.mit.edu	37	chr19	5594052	5594066	+	In_Frame_Del	DEL	CGCTCCCGCTCCATG	CGCTCCCGCTCCATG	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gcatgcgctcgcgctccagcCgctcccgctccatgcgctcc							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:5594052_5594066delCGCTCCCGCTCCATG	ENST00000252542.4	-	15	2307_2321	c.2043_2057delCATGGAGCGGGAGCG	c.(2041-2058)cgg>cg	p.RMERER681del		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	681	Arg-rich.|Glu-rich.|Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GCGCTCCAGCCGCTCCCGCTCCATGCGCTCCCGCT	0.716													14	11	---	---	---	---						-	5594066	CGCTCCCGCTCCATG	-	5594052	7	5	24	1	0	1	0	1	0	0	0	0	13858	652	23	0	832	0	SAFB2	19	5594052	In_Frame_Del	DEL	CGCTCCCGCTCCATG	TCGA-N7-A59B-01A-11D-A28R-08		5594052	53534931	36	2454										
ZNF358	140467	broad.mit.edu	37	chr19	7585559	7585559	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ctgccggatcccagctccaaAcccctccccggctccagatc	7	21	0	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:7585559A>G	ENST00000597229.1	+	2	1601	c.1431A>G	c.(1429-1431)aaA>aaG	p.K477K	ZNF358_ENST00000394341.2_Silent_p.K477K	NM_018083.4	NP_060553.4	Q9NW07	ZN358_HUMAN	zinc finger protein 358	477					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						ccagctccaaacccctccccg	0.682													12	27					0	0	1	0	0	G	7585559	A	G	7585559	2	3	24	1	0	0	0	0	0	0	0	1	17923	40	2	4		4	ZNF358	19	7585559	Silent	SNP	A	TCGA-N7-A59B-01A-11D-A28R-08	1991507	7585559	51543424	37	2455										
ZNF799	90576	broad.mit.edu	37	chr19	12501523	12501523	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gtgaaggctttaccacattgTtgacactcatagggtttctc	9	9	2	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:12501523T>C	ENST00000419318.1	-	4	2342	c.1593A>G	c.(1591-1593)caA>caG	p.Q531Q	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Silent_p.Q563Q			Q96GE5	ZN799_HUMAN	zinc finger protein 799	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TACCACATTGTTGACACTCAT	0.413													17	116					0	0	1	0	0	C	12501523	T	C	12501523	2	2	24	1	0	0	0	0	0	0	0	1	18214	1722	60	4		4	ZNF799	19	12501523	Silent	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08	4915964	12501523	46627460	38	2456										
KIAA1683	80726	broad.mit.edu	37	chr19	18376865	18376865	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gttatcatggctggcaggcgGgtctggggtgagggcttggt	20	6	2	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:18376865G>C	ENST00000392413.3	-	3	1700	c.1485C>G	c.(1483-1485)acC>acG	p.T495T	KIAA1683_ENST00000600328.2_Silent_p.T495T|KIAA1683_ENST00000600359.2_Silent_p.T449T	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	495						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTGGCAGGCGGGTCTGGGGTG	0.572													100	56					0	0	1	0	0	C	18376865	G	C	18376865	2	2	24	1	0	0	0	0	0	0	0	1	8292	1219	43	5		5	KIAA1683	19	18376865	Silent	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	5875342	18376865	40752118	39	2457										
LRP3	4037	broad.mit.edu	37	chr19	33687683	33687683	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gcagtgcggttcctgccttaGgtaagtaagcactttctctc	10	11	1	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:33687683G>C	ENST00000253193.7	+	2	323	c.121_splice	c.e2+1	p.A41_splice	LRP3_ENST00000592484.1_3'UTR	NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	41					receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					TCCTGCCTTAGGTAAGTAAGC	0.552													35	55					0	0	1	0	0	C	33687683	G	C	33687683	5	2	24	1	0	0	0	0	0	0	1	0	9002	1014	35	5	127	5	LRP3	19	33687683	Splice_Site	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	15310818	33687683	25441300	40	2458										
THAP8	199745	broad.mit.edu	37	chr19	36526381	36526381	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gtgtccaggagctccggcttGgcatccactgtggcaggtgc	15	12	0	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:36526381G>T	ENST00000292894.1	-	4	1330	c.786C>A	c.(784-786)gcC>gcA	p.A262A	AC002116.7_ENST00000586962.1_RNA|THAP8_ENST00000538849.1_Silent_p.A117A	NM_152658.2	NP_689871.1	Q8NA92	THAP8_HUMAN	THAP domain containing 8	262							DNA binding|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	8	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCTCCGGCTTGGCATCCACTG	0.537													16	69					3.45872e-05	3.79343e-05	1	1	0	T	36526381	G	T	36526381	2	4	24	1	0	0	0	0	0	0	0	1	15909	1335	47	5		5	THAP8	19	36526381	Silent	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	2838698	36526381	22602602	41	2459										
PAK4	0	broad.mit.edu	37	chr19	39660328	39660328	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tggcagagcctgatcgaggaGtcggctcgccggcccaagcc	15	14	0	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:39660328G>C	ENST00000599386.1	+	3	316	c.135G>C	c.(133-135)gaG>gaC	p.E45D	PAK4_ENST00000360442.3_Missense_Mutation_p.E45D|PAK4_ENST00000358301.3_Missense_Mutation_p.E45D|PAK4_ENST00000321944.4_Missense_Mutation_p.E45D|PAK4_ENST00000593690.1_Missense_Mutation_p.E45D|PAK4_ENST00000599470.1_Missense_Mutation_p.E45D|PAK4_ENST00000435673.2_Missense_Mutation_p.E45D	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	45	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			TGATCGAGGAGTCGGCTCGCC	0.706													28	9					0	0	1	0	0	C	39660328	G	C	39660328	3	2	24	1	0	0	0	0	1	0	0	0	11449	1020	36	5	137	5	PAK4	19	39660328	Missense_Mutation	SNP	G	TCGA-N7-A59B-01A-11D-A28R-08	3133947	39660328	19468655	42	2460										
ZNF284	342909	broad.mit.edu	37	chr19	44591382	44591382	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	gaggcgcttgaatctagataTgattttatcattatttttaa	7	4	2	3			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:44591382T>G	ENST00000421176.3	+	5	1967	c.1751T>G	c.(1750-1752)aTg>aGg	p.M584R	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				AATCTAGATATGATTTTATCA	0.338													17	18					0	0	1	0	0	G	44591382	T	G	44591382	3	3	24	1	0	0	0	0	1	0	0	0	17878	1464	51	4	1765	4	ZNF284	19	44591382	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08	4931054	44591382	14537601	43	2461										
LILRB5	0	broad.mit.edu	37	chr19	54760423	54760423	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tctcatagtagcagcggtatCgccctgcactgtcatacacc	8	14	2	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:54760423C>T	ENST00000450632.1	-	3	361	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	LILRB5_ENST00000449561.2_Missense_Mutation_p.R95Q|LILRB5_ENST00000316219.5_Missense_Mutation_p.R95Q|LILRB5_ENST00000345866.6_Missense_Mutation_p.R95Q			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	95	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCAGCGGTATCGCCCTGCACT	0.627													111	135					0	0	1	0	0	T	54760423	C	T	54760423	3	4	24	1	0	0	0	0	1	0	0	0	8833	884	31	1	1535	1	LILRB5	19	54760423	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	10169041	54760423	4368560	44	2462										
DNMT3B	1789	broad.mit.edu	37	chr20	31381340	31381340	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tgttttgttttcccctcaaaAgtggttaataagtcgaaggt	9	6	1	0			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr20:31381340A>G	ENST00000328111.2	+	10	1387		c.e10-1		DNMT3B_ENST00000344505.4_Intron|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000348286.2_Intron|DNMT3B_ENST00000201963.3_Intron|DNMT3B_ENST00000375623.4_Intron|DNMT3B_ENST00000353855.2_Intron|DNMT3B_ENST00000443239.3_Intron	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta						negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						tcccctcaaaagtggttaata	0.388													14	21					0	0	1	0	0	G	31381340	A	G	31381340	5	3	24	1	0	0	0	0	0	0	1	0	4704	86	3	4	1139	4	DNMT3B	20	31381340	Splice_Site	SNP	A	TCGA-N7-A59B-01A-11D-A28R-08		31381340	31644180	45	2463										
BAGE2	85319	broad.mit.edu	37	chr21	11051960	11051960	+	RNA	DEL	T	T	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tggtgcaaaagtaactgcagTttttgacattacttttaatg							TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr21:11051960delT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gtaactgcagtttttgacatt	0.338													2	4	---	---	---	---						-	11051960	T	-	11051960	6	5	24	0	1	1	0	1	0	0	0	0	1290	1740	60	0		0	BAGE2	21	11051960	RNA	DEL	T	TCGA-N7-A59B-01A-11D-A28R-08		11051960	37077935	46	2464										
BAGE2	85319	broad.mit.edu	37	chr21	11068910	11068911	+	RNA	DEL	AT	AT	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ttatctcgtattctcttatcAtatgtgtaatttaaccataa					rs147061174		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr21:11068910_11068911delAT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ttctcttatcatatgtgtaatt	0.282													4	5	---	---	---	---						-	11068911	AT	-	11068910	6	5	24	0	1	1	0	1	0	0	0	0	1290	232	8	0		0	BAGE2	21	11068910	RNA	DEL	AT	TCGA-N7-A59B-01A-11D-A28R-08	16950	11068910	37060985	47	2465										
BAGE2	85319	broad.mit.edu	37	chr21	11075075	11075077	+	RNA	DEL	ACC	ACC	-													0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	cttgaaaaacttgagaaactAccacttctcaagctttggtt					rs4009967		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr21:11075075_11075077delACC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ttgagaaactaccacttctcaag	0.325													2	4	---	---	---	---						-	11075077	ACC	-	11075075	6	5	24	0	1	1	0	1	0	0	0	0	1290	406	14	0		0	BAGE2	21	11075075	RNA	DEL	ACC	TCGA-N7-A59B-01A-11D-A28R-08	6165	11075075	37054820	48	2466										
RS1	6247	broad.mit.edu	37	chrX	18660259	18660259	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tgaaccgtggaggtgcggtcCgagttgccatagaagaccta	14	9	0	3			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:18660259C>T	ENST00000379984.3	-	6	580	c.540G>A	c.(538-540)tcG>tcA	p.S180S	CDKL5_ENST00000379996.3_Intron|CDKL5_ENST00000379989.3_Intron|RS1_ENST00000476595.1_5'UTR	NM_000330.3	NP_000321.1	O15537	XLRS1_HUMAN	retinoschisin 1	180	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					AGGTGCGGTCCGAGTTGCCAT	0.587													48	40					0	0	1	0	0	T	18660259	C	T	18660259	2	4	24	1	0	0	0	0	0	0	0	1	13744	639	23	1		1	RS1	23	18660259	Silent	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08		18660259	136610301	49	2467										
UBA1	7317	broad.mit.edu	37	chrX	47060923	47060923	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	ggatgaggcccgacacgggtTtgagagcggggactttgtct	17	8	1	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:47060923T>C	ENST00000335972.6	+	8	908	c.725T>C	c.(724-726)tTt>tCt	p.F242S	UBA1_ENST00000377351.4_Missense_Mutation_p.F242S	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	242	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CGACACGGGTTTGAGAGCGGG	0.547													11	31					0	0	1	0	0	C	47060923	T	C	47060923	3	2	24	1	0	0	0	0	1	0	0	0	16887	1841	64	4	751	4	UBA1	23	47060923	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08	28400664	47060923	108209637	50	2468										
PGAM4	441531	broad.mit.edu	37	chrX	77224931	77224931	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	atcaatggcatctagcactgTccagagggtccggatcactc	10	12	3	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:77224931T>A	ENST00000458128.1	-	1	204	c.205A>T	c.(205-207)Aca>Tca	p.T69S	ATP7A_ENST00000343533.5_Intron|ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000341514.6_Intron	NM_001029891.2	NP_001025062.1	Q8N0Y7	PGAM4_HUMAN	phosphoglycerate mutase family member 4	69					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						TCTAGCACTGTCCAGAGGGTC	0.577													90	112					0	0	1	0	0	A	77224931	T	A	77224931	3	1	24	1	0	0	0	0	1	0	0	0	11822	1667	58	4	563	4	PGAM4	23	77224931	Missense_Mutation	SNP	T	TCGA-N7-A59B-01A-11D-A28R-08	30164008	77224931	78045629	51	2469										
GPRASP1	9737	broad.mit.edu	37	chrX	101912152	101912152	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tcaggaatctttgcttcagcCtgatcagcctagtcctgagt	9	11	4	2			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:101912152C>T	ENST00000537097.1	+	6	4124	c.3311C>T	c.(3310-3312)cCt>cTt	p.P1104L	RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000444152.1_Missense_Mutation_p.P1104L|GPRASP1_ENST00000415986.1_Missense_Mutation_p.P1104L|GPRASP1_ENST00000361600.5_Missense_Mutation_p.P1104L	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	1104	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTGCTTCAGCCTGATCAGCCT	0.488													101	93					0	0	1	0	0	T	101912152	C	T	101912152	3	4	24	1	0	0	0	0	1	0	0	0	6762	681	24	3	3313	3	GPRASP1	23	101912152	Missense_Mutation	SNP	C	TCGA-N7-A59B-01A-11D-A28R-08	24687221	101912152	53358408	52	2470										
PNMA5	114824	broad.mit.edu	37	chrX	152159976	152159976	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0188679245283019	1	1	0.326266618756737	1.25068870523416	0	1	1	0	tggcattgtcttccctcctgAacattctccctaggaccctg	7	15	2	1			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:152159976A>T	ENST00000439251.1	-	2	605	c.167T>A	c.(166-168)tTc>tAc	p.F56Y	PNMA5_ENST00000361887.5_Missense_Mutation_p.F56Y|PNMA5_ENST00000452693.1_Missense_Mutation_p.F56Y|PNMA5_ENST00000535214.1_Missense_Mutation_p.F56Y	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	56					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					ttccctcctgaacattctccc	0.522													56	99					0	0	1	0	0	T	152159976	A	T	152159976	3	4	24	1	0	0	0	0	1	0	0	0	12203	246	9	4	1183	4	PNMA5	23	152159976	Missense_Mutation	SNP	A	TCGA-N7-A59B-01A-11D-A28R-08	50247824	152159976	3110584	53	2471										
CLCNKA	0	broad.mit.edu	37	chr1	16357051	16357051	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tagtgcatgcactgcccgtgCtgatggcggtgctggcagcc	15	12	0	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr1:16357051C>G	ENST00000375692.1	+	16	1632	c.1504C>G	c.(1504-1506)Ctg>Gtg	p.L502V	CLCNKA_ENST00000439316.2_Missense_Mutation_p.L459V|CLCNKA_ENST00000420078.1_Missense_Mutation_p.L502V|CLCNKA_ENST00000331433.4_Missense_Mutation_p.L502V|CLCNKA_ENST00000464764.1_3'UTR			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	502					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	ACTGCCCGTGCTGATGGCGGT	0.617													14	78					0	0	1	0	0	G	16357051	C	G	16357051	3	3	25	1	0	0	0	0	1	0	0	0	3492	796	28	5	1558	5	CLCNKA	1	16357051	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		16357051	232893570	1	2472										
PCSK9	255738	broad.mit.edu	37	chr1	55512217	55512217	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ccttgaagttgccccatgtcGactacatcgaggaggactcc	10	13	0	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr1:55512217G>A	ENST00000302118.5	+	3	711	c.421G>A	c.(421-423)Gac>Aac	p.D141N	PCSK9_ENST00000543384.1_Intron|PCSK9_ENST00000452118.2_Missense_Mutation_p.D141N	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	141					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GCCCCATGTCGACTACATCGA	0.602													33	48					0	0	1	0	0	A	55512217	G	A	55512217	3	1	25	1	0	0	0	0	1	0	0	0	11652	1058	37	1	431	1	PCSK9	1	55512217	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	39155166	55512217	193738404	2	2473										
SYDE2	84144	broad.mit.edu	37	chr1	85656053	85656053	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ataccaaggtcatcatcctcAggaatgggattgtaccatat	8	9	3	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr1:85656053A>G	ENST00000341460.5	-	2	1177	c.1128T>C	c.(1126-1128)ccT>ccC	p.P376P		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	376					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		CATCATCCTCAGGAATGGGAT	0.418													8	16					0	0	1	0	0	G	85656053	A	G	85656053	2	3	25	1	0	0	0	0	0	0	0	1	15492	175	7	4		4	SYDE2	1	85656053	Silent	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	30143836	85656053	163594568	3	2474										
PTGFRN	5738	broad.mit.edu	37	chr1	117491980	117491980	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ggctcccgcgtgttggcgcgGcttgaccgtgattccctggt	15	13	0	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr1:117491980G>A	ENST00000393203.2	+	4	1146	c.999G>A	c.(997-999)cgG>cgA	p.R333R		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	333	Ig-like C2-type 3.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TGTTGGCGCGGCTTGACCGTG	0.577													42	54					0	0	1	0	0	A	117491980	G	A	117491980	2	1	25	1	0	0	0	0	0	0	0	1	12799	1190	42	3		3	PTGFRN	1	117491980	Silent	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	31835927	117491980	131758641	4	2475										
CD1B	910	broad.mit.edu	37	chr1	158298715	158298715	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	accacccacaactcaccggcGcctcatataccataatgcaa	4	17	2	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr1:158298715G>A	ENST00000368168.3	-	5	1083	c.976C>T	c.(976-978)Cgc>Tgc	p.R326C		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	326					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					ACTCACCGGCGCCTCATATAC	0.378													13	40					0	0	1	0	0	A	158298715	G	A	158298715	3	1	25	1	0	0	0	0	1	0	0	0	2997	1087	38	1	33	1	CD1B	1	158298715	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	40806735	158298715	90951906	5	2476										
CR1	1378	broad.mit.edu	37	chr1	207679361	207679361	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gaatgccgccctggttattcCggaagaccgttttctatcat	9	11	2	1	rs142605009	by1000genomes	TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr1:207679361C>T	ENST00000367049.4	+	2	234	c.234C>T	c.(232-234)tcC>tcT	p.S78S	CR1_ENST00000367050.4_3'UTR|CR1_ENST00000367053.1_Silent_p.S78S|CR1_ENST00000367051.1_Silent_p.S78S|CR1_ENST00000367052.1_Silent_p.S78S|CR1_ENST00000400960.2_Silent_p.S78S	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	78	Sushi 1.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTGGTTATTCCGGAAGACCGT	0.483													15	132					0	0	1	0	0	T	207679361	C	T	207679361	2	4	25	1	0	0	0	0	0	0	0	1	3863	639	23	1		1	CR1	1	207679361	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	49380646	207679361	41571260	6	2477										
C2orf16	84226	broad.mit.edu	37	chr2	27801239	27801239	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ccagggccatcccttcaaatCgtaaaatctgaggagttagc	9	11	2	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr2:27801239C>T	ENST00000408964.2	+	1	1851	c.1800C>T	c.(1798-1800)atC>atT	p.I600I		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	600										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CCCTTCAAATCGTAAAATCTG	0.393													12	17					0	0	1	0	0	T	27801239	C	T	27801239	2	4	25	1	0	0	0	0	0	0	0	1	2171	874	31	1		1	C2orf16	2	27801239	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		27801239	215398134	7	2478										
SMEK2	57223	broad.mit.edu	37	chr2	55792098	55792098	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	atttagtcttcaatcctttgAatgtctgaacatattcaatc	4	8	4	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr2:55792098A>T	ENST00000272313.5	-	12	2087	c.1760T>A	c.(1759-1761)tTc>tAc	p.F587Y	SMEK2_ENST00000345102.5_Missense_Mutation_p.F672Y|SMEK2_ENST00000407823.3_Missense_Mutation_p.F640Y	NM_020463.2	NP_065196.1	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	672						microtubule organizing center|nucleus	protein binding			kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CAATCCTTTGAATGTCTGAAC	0.313													6	15					0	0	1	0	0	T	55792098	A	T	55792098	3	4	25	1	0	0	0	0	1	0	0	0	14847	246	9	4	550	4	SMEK2	2	55792098	Missense_Mutation	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	27990859	55792098	187407275	8	2479										
ALMS1	7840	broad.mit.edu	37	chr2	73613273	73613273	+	Frame_Shift_Del	DEL	C	C	-													0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ggattttgcctccgctgtcgCccccgcagcaccgctactcg							TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr2:73613273delC	ENST00000264448.6	+	1	388	c.277delC	c.(277-279)ccfs	p.P94fs	ALMS1_ENST00000377715.1_Frame_Shift_Del_p.P94fs|ALMS1_ENST00000409009.1_Frame_Shift_Del_p.P94fs	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	94					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TCCGCTGTCGCCCCCGCAGCA	0.701													2	4	---	---	---	---						-	73613273	C	-	73613273	7	5	25	1	0	1	0	1	0	0	0	0	531	739	26	0	279	0	ALMS1	2	73613273	Frame_Shift_Del	DEL	C	TCGA-N8-A4PI-01A-21D-A28R-08	17821175	73613273	169586100	9	2480										
LIPT1	51601	broad.mit.edu	37	chr2	99778887	99778887	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	caaaagatttgaccttttacTtgatggacagtttaaaatct	6	6	1	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr2:99778887T>C	ENST00000393477.3	+	4	819	c.467T>C	c.(466-468)cTt>cCt	p.L156P	MRPL30_ENST00000410042.1_Intron|LIPT1_ENST00000393471.2_Missense_Mutation_p.L156P|LIPT1_ENST00000393473.2_Missense_Mutation_p.L156P|LIPT1_ENST00000393474.3_Missense_Mutation_p.L156P|LIPT1_ENST00000340066.1_Missense_Mutation_p.L156P	NM_145197.2	NP_660198.1	Q9Y234	LIPT_HUMAN	lipoyltransferase 1	156					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity			large_intestine(6)|lung(1)	7					Lipoic Acid(DB00166)	GACCTTTTACTTGATGGACAG	0.413													10	58					0	0	1	0	0	C	99778887	T	C	99778887	3	2	25	1	0	0	0	0	1	0	0	0	8869	1609	56	4	469	4	LIPT1	2	99778887	Missense_Mutation	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08	26165614	99778887	143420486	10	2481										
ARPP21	10777	broad.mit.edu	37	chr3	35778809	35778809	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tccccgcagccccaacagcaGgtccagccaccgcagccaca	8	21	0	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr3:35778809G>A	ENST00000187397.4	+	16	2055	c.1599G>A	c.(1597-1599)caG>caA	p.Q533Q	ARPP21_ENST00000458225.1_Silent_p.Q499Q|ARPP21_ENST00000337271.5_Silent_p.Q479Q|ARPP21_ENST00000417925.1_Silent_p.Q499Q|ARPP21_ENST00000444190.1_Silent_p.Q479Q	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	533	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CCCAACAGCAGGTCCAGCCAC	0.647													21	30					0	0	1	0	0	A	35778809	G	A	35778809	2	1	25	1	0	0	0	0	0	0	0	1	977	991	35	3		3	ARPP21	3	35778809	Silent	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08		35778809	162243621	11	2482										
MYRIP	25924	broad.mit.edu	37	chr3	40286039	40286039	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gcactgatgagacccatctgGcggatctggaggaccaggtg	15	10	2	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr3:40286039G>A	ENST00000302541.6	+	13	2545	c.2203G>A	c.(2203-2205)Gcg>Acg	p.A735T	MYRIP_ENST00000425621.1_Missense_Mutation_p.A670T|MYRIP_ENST00000396217.3_Missense_Mutation_p.A646T|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000539167.1_Missense_Mutation_p.A548T|MYRIP_ENST00000444716.1_Missense_Mutation_p.A735T	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	735	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GACCCATCTGGCGGATCTGGA	0.607													23	24					0	0	1	0	0	A	40286039	G	A	40286039	3	1	25	1	0	0	0	0	1	0	0	0	10147	1203	42	3	2249	3	MYRIP	3	40286039	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	4507230	40286039	157736391	12	2483										
PTPN23	25930	broad.mit.edu	37	chr3	47452431	47452431	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ccctcagcctccccatccccCactggcatatggtcctgccc	6	22	1	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr3:47452431C>G	ENST00000265562.4	+	20	3220	c.3143C>G	c.(3142-3144)cCa>cGa	p.P1048R	PTPN23_ENST00000431726.1_Missense_Mutation_p.P922R	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	1048	His.|Pro-rich.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCCCATCCCCCACTGGCATAT	0.672													24	28					0	0	1	0	0	G	47452431	C	G	47452431	3	3	25	1	0	0	0	0	1	0	0	0	12839	594	21	5	3221	5	PTPN23	3	47452431	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	7166392	47452431	150569999	13	2484										
POLQ	10721	broad.mit.edu	37	chr3	121260219	121260219	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gaggtagtatttcttctcttTagccacagaaacaaagggaa	9	7	2	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr3:121260219T>A	ENST00000264233.5	-	3	579	c.451A>T	c.(451-453)Aaa>Taa	p.K151*		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	151	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TTCTTCTCTTTAGCCACAGAA	0.358								DNA polymerases (catalytic subunits)					47	54					0	0	1	0	0	A	121260219	T	A	121260219	4	1	25	1	0	0	0	0	0	1	0	0	12255	1763	61	4	7433	4	POLQ	3	121260219	Nonsense_Mutation	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08	73807788	121260219	76762211	14	2485										
ILDR1	286676	broad.mit.edu	37	chr3	121724124	121724124	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gatcttgcgctgccggtaatCtacccccagcacgggctcat	10	15	3	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr3:121724124C>T	ENST00000273691.3	-	3	451	c.346G>A	c.(346-348)Gat>Aat	p.D116N	ILDR1_ENST00000344209.5_Missense_Mutation_p.D116N|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Missense_Mutation_p.D128N|ILDR1_ENST00000393631.1_Missense_Mutation_p.D116N	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	116	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		TGCCGGTAATCTACCCCCAGC	0.652													13	26					0	0	1	0	0	T	121724124	C	T	121724124	3	4	25	1	0	0	0	0	1	0	0	0	7752	913	32	3	1182	3	ILDR1	3	121724124	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	463905	121724124	76298306	15	2486										
STAG1	10274	broad.mit.edu	37	chr3	136323151	136323151	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	aataaaaacttaaaatttacCtgcattgcacttttccccag	3	10	0	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr3:136323151C>T	ENST00000383202.2	-	4	553	c.297_splice	c.e4+1	p.Q99_splice	STAG1_ENST00000236698.5_Splice_Site_p.Q99_splice|STAG1_ENST00000434713.2_5'UTR|STAG1_ENST00000480733.1_Splice_Site_p.Q99_splice	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	99					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TAAAATTTACCTGCATTGCAC	0.403													43	48					0	0	1	0	0	T	136323151	C	T	136323151	5	4	25	1	0	0	0	0	0	0	1	0	15297	695	24	3	3603	3	STAG1	3	136323151	Splice_Site	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	14599027	136323151	61699279	16	2487										
SLAIN2	57606	broad.mit.edu	37	chr4	48385799	48385799	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tatgcaacctcaggcttcagCcagtaagtatccttcttatg	7	11	3	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr4:48385799C>A	ENST00000264313.6	+	6	1776	c.1358C>A	c.(1357-1359)gCc>gAc	p.A453D	SLAIN2_ENST00000512093.1_Missense_Mutation_p.A260D	NM_020846.1	NP_065897.1	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	453						centrosome				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)	13						CAGGCTTCAGCCAGTAAGTAT	0.353													6	12					0.00116845	0.00118269	1	1	0	A	48385799	C	A	48385799	3	1	25	1	0	0	0	0	1	0	0	0	14420	739	26	5	1380	5	SLAIN2	4	48385799	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		48385799	142768477	17	2488										
EPHA5	2044	broad.mit.edu	37	chr4	66356251	66356251	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tttcaggccgctttgccgggGaaggtacctgacatgaccgc	13	12	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr4:66356251G>A	ENST00000273854.3	-	5	1846	c.1246C>T	c.(1246-1248)Ccc>Tcc	p.P416S	EPHA5_ENST00000511294.1_Missense_Mutation_p.P416S|EPHA5_ENST00000354839.4_Missense_Mutation_p.P416S|EPHA5_ENST00000432638.2_Intron	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	416	Fibronectin type-III 1.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTTTGCCGGGGAAGGTACCTG	0.498										TSP Lung(17;0.13)			10	42					0	0	1	0	0	A	66356251	G	A	66356251	3	1	25	1	0	0	0	0	1	0	0	0	5198	1174	41	3	1923	3	EPHA5	4	66356251	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	17970452	66356251	124798025	18	2489										
USP53	54532	broad.mit.edu	37	chr4	120213506	120213506	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	atttcagatcacatgtacatGaagacaatggaaagttattt	7	5	2	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr4:120213506G>A	ENST00000450251.1	+	15	2906	c.2362G>A	c.(2362-2364)Gaa>Aaa	p.E788K	USP53_ENST00000274030.6_Missense_Mutation_p.E788K			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	788					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						ACATGTACATGAAGACAATGG	0.328													11	12					0	0	1	0	0	A	120213506	G	A	120213506	3	1	25	1	0	0	0	0	1	0	0	0	17143	1291	45	3	2420	3	USP53	4	120213506	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	53857255	120213506	70940770	19	2490										
FBXW7	0	broad.mit.edu	37	chr4	153249385	153249385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ttcatgaagatgcatacaacGcacagtggaagtatgcccat	9	9	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr4:153249385G>A	ENST00000281708.4	-	9	2622	c.1393C>T	c.(1393-1395)Cgt>Tgt	p.R465C	FBXW7_ENST00000296555.5_Missense_Mutation_p.R347C|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465C|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385C|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465C|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289C	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465C(71)|p.R226C(11)|p.R385C(11)|p.R347C(3)|p.R465Y(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCATACAACGCACAGTGGAA	0.413			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								55	71					0	0	1	0	0	A	153249385	G	A	153249385	3	1	25	1	0	0	0	0	1	0	0	0	5801	1087	38	1	746	1	FBXW7	4	153249385	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	33035879	153249385	37904891	20	2491										
DNAH5	1767	broad.mit.edu	37	chr5	13865875	13865875	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	acagtttctatgacactgttGtacagagtatatattttctg	7	6	2	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr5:13865875G>T	ENST00000265104.4	-	27	4361	c.4257C>A	c.(4255-4257)taC>taA	p.Y1419*	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1419	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGACACTGTTGTACAGAGTAT	0.353									Kartagener syndrome				21	19					8.10497e-08	8.62452e-08	1	1	0	T	13865875	G	T	13865875	4	4	25	1	0	0	0	0	0	1	0	0	4632	1372	48	5	9829	5	DNAH5	5	13865875	Nonsense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08		13865875	167049385	21	2492										
PIK3R1	5295	broad.mit.edu	37	chr5	67589269	67589270	+	Frame_Shift_Ins	INS	-	-	T													0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tagctcagtataatcccaaaINSttggatgtgaaattacttta							TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr5:67589269_67589270insT	ENST00000521381.1	+	10	1873_1874	c.1257_1258insT	c.(1255-1260)aatggafs	p.G420fs	PIK3R1_ENST00000274335.5_Frame_Shift_Ins_p.G420fs|PIK3R1_ENST00000523872.1_Frame_Shift_Ins_p.G57fs|PIK3R1_ENST00000336483.5_Frame_Shift_Ins_p.G150fs|PIK3R1_ENST00000320694.8_Frame_Shift_Ins_p.G120fs|PIK3R1_ENST00000521657.1_Frame_Shift_Ins_p.G420fs|PIK3R1_ENST00000396611.1_Frame_Shift_Ins_p.G420fs	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	420	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ATAATCCCAAATTGGATGTGAA	0.347			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			12	14	---	---	---	---						T	67589270	-	T	67589269	7	5	25	1	0	1	1	0	0	0	0	0	11965	98	4	0	1421	0	PIK3R1	5	67589269	Frame_Shift_Ins	INS	-	TCGA-N8-A4PI-01A-21D-A28R-08	53723394	67589269	113325991	22	2493										
PIK3R1	5295	broad.mit.edu	37	chr5	67589588	67589620	+	In_Frame_Del	DEL	GAATATAACACTCAGTTTCAAGAAAAAAGTCGA	GAATATAACACTCAGTTTCAAGAAAAAAGTCGA	-													0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ctgtagggaaaaaattacatGaatataacactcagtttcaa					rs17852841		TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr5:67589588_67589620delGAATATAACACTCAGTTTCAAGAAAAAAGTCGA	ENST00000521381.1	+	11	1967_1999	c.1351_1383delGAATATAACACTCAGTTTCAAGAAAAAAGTCGA	c.(1351-1383)del	p.EYNTQFQEKSR451del	PIK3R1_ENST00000274335.5_In_Frame_Del_p.EYNTQFQEKSR451del|PIK3R1_ENST00000523872.1_In_Frame_Del_p.EYNTQFQEKSR88del|PIK3R1_ENST00000336483.5_In_Frame_Del_p.EYNTQFQEKSR181del|PIK3R1_ENST00000320694.8_In_Frame_Del_p.EYNTQFQEKSR151del|PIK3R1_ENST00000521657.1_In_Frame_Del_p.EYNTQFQEKSR451del|PIK3R1_ENST00000396611.1_In_Frame_Del_p.EYNTQFQEKSR451del	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	451			E -> K (in dbSNP:rs17852841).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.N453_T454insN(3)|p.H450_E451del(2)|p.Y452_Q455>SGGSRIK(1)|p.Y152N(1)|p.F456_R461>S(1)|p.E451_Y452delEY(1)|p.T454_Q455>Q(1)|p.T454I(1)|p.E462_R465delEYDR(1)|p.Y452N(1)|p.R461*(1)|p.Q187P(1)|p.Q157P(1)|p.453_454insN(1)|p.K459del(1)|p.K459_S460>N(1)|p.?(1)|p.Q457P(1)|p.Q457_R461del(1)|p.S460fs*5(1)|p.T454_D464del(1)|p.G446_Y452>VI(1)|p.E458*(1)|p.0?(1)|p.K459E(1)|p.Q455K(1)|p.F456_R461del(1)|p.Y182N(1)|p.E451_Y452del(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATATGATA	0.27			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			7	32	---	---	---	---						-	67589620	GAATATAACACTCAGTTTCAAGAAAAAAGTCGA	-	67589588	7	5	25	1	0	1	0	1	0	0	0	0	11965	1291	45	0	1519	0	PIK3R1	5	67589588	In_Frame_Del	DEL	GAATATAACACTCAGTTTCAAGAAAAAAGTCGA	TCGA-N8-A4PI-01A-21D-A28R-08	319	67589588	113325672	23	2494										
F12	2161	broad.mit.edu	37	chr5	176832137	176832137	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gcttgctcagttctataccaTatctcattcttgtggaaaaa	6	9	4	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr5:176832137T>C	ENST00000253496.3	-	6	495	c.447A>G	c.(445-447)atA>atG	p.I149M		NM_000505.3	NP_000496.2	P00748	FA12_HUMAN	coagulation factor XII (Hageman factor)	149	Fibronectin type-I.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTATACCATATCTCATTCT	0.552									Hereditary Angioedema				18	35					0	0	1	0	0	C	176832137	T	C	176832137	3	2	25	1	0	0	0	0	1	0	0	0	5367	1396	49	4	1436	4	F12	5	176832137	Missense_Mutation	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08	109242549	176832137	4083123	24	2495										
FAM153A	285596	broad.mit.edu	37	chr5	177156485	177156485	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gaggaaagaagacgactttaCcatgtgaacccctgtggctt	11	9	0	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr5:177156485C>G	ENST00000440605.3	-	16	986		c.e16+1		FAM153A_ENST00000393518.3_Intron|FAM153A_ENST00000510276.1_Splice_Site|FAM153A_ENST00000513554.1_Intron	NM_173663.3	NP_775934.3	Q9UHL3	F153A_HUMAN	family with sequence similarity 153, member A											kidney(6)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	11	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GACGACTTTACCATGTGAACC	0.443													28	124					0	0	1	0	0	G	177156485	C	G	177156485	5	3	25	1	0	0	0	0	0	0	1	0	5490	521	18	5	249	5	FAM153A	5	177156485	Splice_Site	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	324348	177156485	3758775	25	2496										
HIST1H2AB	8335	broad.mit.edu	37	chr6	26033580	26033580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gatgcgggtcttcttgttgtCgcgggccgcattgcccgcca	14	13	2	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr6:26033580C>T	ENST00000259791.2	-	1	216	c.217G>A	c.(217-219)Gac>Aac	p.D73N		NM_003513.2	NP_003504.2	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	73					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						TTCTTGTTGTCGCGGGCCGCA	0.647													54	54					0	0	1	0	0	T	26033580	C	T	26033580	3	4	25	1	0	0	0	0	1	0	0	0	7169	884	31	1	179	1	HIST1H2AB	6	26033580	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		26033580	145081487	26	2497										
CNOT4	4850	broad.mit.edu	37	chr7	135080618	135080618	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	aaaccaggtggtggtgaaggCgtatcactgttagatatctg	13	6	2	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr7:135080618C>T	ENST00000428680.2	-	9	1167	c.888G>A	c.(886-888)acG>acA	p.T296T	CNOT4_ENST00000361528.4_Silent_p.T296T|CNOT4_ENST00000414802.1_Silent_p.T299T|CNOT4_ENST00000423368.2_Silent_p.T299T|CNOT4_ENST00000451834.1_Silent_p.T296T|CNOT4_ENST00000541284.1_Silent_p.T299T|CNOT4_ENST00000315544.5_Silent_p.T299T|CNOT4_ENST00000356162.4_Silent_p.T299T	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	299					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						GTGGTGAAGGCGTATCACTGT	0.368													12	33					0	0	1	0	0	T	135080618	C	T	135080618	2	4	25	1	0	0	0	0	0	0	0	1	3644	755	27	1		1	CNOT4	7	135080618	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		135080618	24058045	27	2498										
GIMAP4	55303	broad.mit.edu	37	chr7	150269308	150269308	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	agtgcaacaggaaacagcatCcttggccggaaagtgtttca	11	9	1	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr7:150269308C>T	ENST00000255945.2	+	3	325	c.150C>T	c.(148-150)atC>atT	p.I50I	GIMAP4_ENST00000461940.1_Silent_p.I64I|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	50							GTP binding	p.I50>?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAACAGCATCCTTGGCCGGA	0.478													19	29					0	0	1	0	0	T	150269308	C	T	150269308	2	4	25	1	0	0	0	0	0	0	0	1	6422	845	30	3		3	GIMAP4	7	150269308	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	15188690	150269308	8869355	28	2499										
ARHGEF10	9639	broad.mit.edu	37	chr8	1871979	1871979	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tttacagctgtgttcaatacGttcacccctgccatcaagga	7	12	3	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr8:1871979G>A	ENST00000518288.1	+	22	2662	c.2499G>A	c.(2497-2499)acG>acA	p.T833T	ARHGEF10_ENST00000349830.3_Silent_p.T809T|ARHGEF10_ENST00000520359.1_Silent_p.T771T|ARHGEF10_ENST00000262112.6_Silent_p.T834T|ARHGEF10_ENST00000398564.1_Silent_p.T834T			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	834					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TGTTCAATACGTTCACCCCTG	0.517													15	62					0	0	1	0	0	A	1871979	G	A	1871979	2	1	25	1	0	0	0	0	0	0	0	1	891	1132	40	1		1	ARHGEF10	8	1871979	Silent	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08		1871979	144492043	29	2500										
CYP7B1	9420	broad.mit.edu	37	chr8	65527731	65527731	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cgcagaagataatacattgcCcagaacatagttggaatagt	9	7	0	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr8:65527731C>T	ENST00000310193.3	-	4	1082	c.909G>A	c.(907-909)tgG>tgA	p.W303*	CYP7B1_ENST00000523954.1_5'UTR	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	303					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AATACATTGCCCAGAACATAG	0.443													4	41					0	0	1	0	0	T	65527731	C	T	65527731	4	4	25	1	0	0	0	0	0	1	0	0	4220	624	22	3	623	3	CYP7B1	8	65527731	Nonsense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	63655752	65527731	80836291	30	2501										
SMARCA2	6595	broad.mit.edu	37	chr9	2039779	2039779	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	caacaacagcagcagcaacaGcagcagcagcagcagcagca	10	14	0	0	rs113070757	byFrequency	TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr9:2039779G>A	ENST00000382203.1	+	4	878	c.669G>A	c.(667-669)caG>caA	p.Q223Q	SMARCA2_ENST00000349721.2_Silent_p.Q223Q|SMARCA2_ENST00000491574.1_3'UTR|SMARCA2_ENST00000357248.2_Silent_p.Q223Q|SMARCA2_ENST00000382194.1_Silent_p.Q223Q			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	223	Poly-Gln.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agcagcaacagcagcagcagc	0.642													4	29					0	0	1	0	0	A	2039779	G	A	2039779	2	1	25	1	0	0	0	0	0	0	0	1	14822	962	34	3		3	SMARCA2	9	2039779	Silent	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08		2039779	139173652	31	2502										
CDK20	23552	broad.mit.edu	37	chr9	90584735	90584735	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cagacttgagggtttggggtGcccaagatgcgaagcacata	14	8	0	3	rs113461285		TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr9:90584735G>A	ENST00000375883.3	-	5	906	c.600C>T	c.(598-600)ggC>ggT	p.G200G	CDK20_ENST00000325303.8_Silent_p.G221G|CDK20_ENST00000605159.1_Silent_p.G200G|CDK20_ENST00000375871.4_Intron|CDK20_ENST00000336654.5_Silent_p.G213G	NM_001170639.1|NM_012119.4|NM_178432.3	NP_001164110.1|NP_036251.2|NP_848519.1	Q8IZL9	CDK20_HUMAN	cyclin-dependent kinase 20	221	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						GGTTTGGGGTGCCCAAGATGC	0.577													43	50					0	0	1	0	0	A	90584735	G	A	90584735	2	1	25	1	0	0	0	0	0	0	0	1	3159	1306	46	3		3	CDK20	9	90584735	Silent	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	88544956	90584735	50628696	32	2503										
PTEN	5728	broad.mit.edu	37	chr10	89692904	89692904	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	actgtaaagctggaaagggaCgaactggtgtaatgatatgt	13	4	0	1	rs121913292		TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr10:89692904C>T	ENST00000371953.3	+	5	1745	c.388C>T	c.(388-390)Cga>Tga	p.R130*		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).|R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(102)|p.R130*(63)|p.0?(37)|p.?(5)|p.R55fs*1(5)|p.K128_R130del(3)|p.Y27fs*1(2)|p.R130R(1)|p.A121_F145del(1)|p.R130fs*4(1)|p.G129fs*51(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.K128fs*47(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(KMBC2_URINARY_TRACT)|R130G(OV56_OVARY)	31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			39	10					0	0	1	0	0	T	89692904	C	T	89692904	4	4	25	1	0	0	0	0	0	1	0	0	12786	528	19	1	406	1	PTEN	10	89692904	Nonsense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		89692904	45841843	33	2504										
DMBT1	1755	broad.mit.edu	37	chr10	124339330	124339330	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	atgatgtgcgctgctcaggaCatgagtcctacctgtggagc	13	10	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr10:124339330C>A	ENST00000368909.3	+	10	1022	c.916C>A	c.(916-918)Cat>Aat	p.H306N	DMBT1_ENST00000368955.3_Missense_Mutation_p.H306N|DMBT1_ENST00000344338.3_Missense_Mutation_p.H306N|DMBT1_ENST00000368956.2_Missense_Mutation_p.H306N|DMBT1_ENST00000330163.4_Missense_Mutation_p.H306N|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000338354.3_Missense_Mutation_p.H306N	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	306	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTGCTCAGGACATGAGTCCTA	0.607													6	127					0.00307968	0.00307968	1	1	0	A	124339330	C	A	124339330	3	1	25	1	0	0	0	0	1	0	0	0	4605	478	17	5	954	5	DMBT1	10	124339330	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	34646426	124339330	11195417	34	2505										
DGKZ	8525	broad.mit.edu	37	chr11	46397946	46397946	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cccaagtggtgcttcctggaCggtgagtctactcccagggt	13	12	1	1	rs146211585	byFrequency	TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr11:46397946C>T	ENST00000454345.1	+	24	2849	c.2725_splice	c.e24+1	p.D908_splice	DGKZ_ENST00000318201.8_Splice_Site_p.D697_splice|DGKZ_ENST00000343674.6_Splice_Site_p.D736_splice|DGKZ_ENST00000532868.2_Splice_Site_p.D724_splice|DGKZ_ENST00000395574.3_Splice_Site_p.D686_splice|DGKZ_ENST00000456247.2_Splice_Site_p.D719_splice|DGKZ_ENST00000528615.1_Splice_Site_p.D498_splice|DGKZ_ENST00000543978.1_Splice_Site_p.D72_splice|DGKZ_ENST00000421244.2_Splice_Site_p.D720_splice|DGKZ_ENST00000527911.1_Splice_Site_p.D720_splice	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	908					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		GCTTCCTGGACGGTGAGTCTA	0.612													38	103					0	0	1	0	0	T	46397946	C	T	46397946	5	4	25	1	0	0	0	0	0	0	1	0	4502	550	19	1	3261	1	DGKZ	11	46397946	Splice_Site	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		46397946	88608570	35	2506										
OR4C3	256144	broad.mit.edu	37	chr11	48347283	48347283	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gagatgcaaagccctctccaCctgtggagcccacttcattg	9	14	2	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr11:48347283C>G	ENST00000319856.4	+	1	812	c.791C>G	c.(790-792)aCc>aGc	p.T264S		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GCCCTCTCCACCTGTGGAGCC	0.458													46	39					0	0	1	0	0	G	48347283	C	G	48347283	3	3	25	1	0	0	0	0	1	0	0	0	11097	507	18	5	793	5	OR4C3	11	48347283	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	1949337	48347283	86659233	36	2507										
FAM111A	63901	broad.mit.edu	37	chr11	58920290	58920290	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ggattgttcattttaacttgTcggcatgtaatagatagcat	9	5	1	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr11:58920290T>G	ENST00000528737.1	+	5	3967	c.1149T>G	c.(1147-1149)tgT>tgG	p.C383W	FAM111A_ENST00000361723.3_Missense_Mutation_p.C383W|FAM111A_ENST00000420244.1_Missense_Mutation_p.C383W|FAM111A_ENST00000531147.1_Missense_Mutation_p.C383W|FAM111A_ENST00000533703.1_Missense_Mutation_p.C383W			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	383					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				TTTTAACTTGTCGGCATGTAA	0.428													14	86					0	0	1	0	0	G	58920290	T	G	58920290	3	3	25	1	0	0	0	0	1	0	0	0	5430	1673	58	4	1155	4	FAM111A	11	58920290	Missense_Mutation	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08	10573007	58920290	76086226	37	2508										
AHNAK	79026	broad.mit.edu	37	chr11	62292206	62292206	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ctttcattttagggcctttaAgattgaggtccaaatcaggc	9	8	2	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr11:62292206A>G	ENST00000378024.4	-	5	9957	c.9683T>C	c.(9682-9684)cTt>cCt	p.L3228P	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3228					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGGGCCTTTAAGATTGAGGTC	0.408													99	68					0	0	1	0	0	G	62292206	A	G	62292206	3	3	25	1	0	0	0	0	1	0	0	0	411	72	3	4	8109	4	AHNAK	11	62292206	Missense_Mutation	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	3371916	62292206	72714310	38	2509										
NTM	50863	broad.mit.edu	37	chr11	132180094	132180094	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gaagcctcagcagtcccctcAgcagaattccagtggtacaa	9	13	2	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr11:132180094A>C	ENST00000374786.1	+	5	1229	c.750A>C	c.(748-750)tcA>tcC	p.S250S	NTM_ENST00000374791.3_Silent_p.S250S|NTM_ENST00000374784.1_Silent_p.S250S|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000425719.2_Silent_p.S250S|NTM_ENST00000427481.2_Silent_p.S241S|NTM_ENST00000539799.1_Silent_p.S250S	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	250	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						CAGTCCCCTCAGCAGAATTCC	0.507													76	78					0	0	1	0	0	C	132180094	A	C	132180094	2	2	25	1	0	0	0	0	0	0	0	1	10746	175	7	4		4	NTM	11	132180094	Silent	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	69887888	132180094	2826422	39	2510										
CHD4	1108	broad.mit.edu	37	chr12	6697558	6697558	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ggcccccagctcgagtggaaAgcaagaagcagaactgctga	13	11	0	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr12:6697558A>G	ENST00000309577.6	-	23	3534	c.3371T>C	c.(3370-3372)cTt>cCt	p.L1124P	CHD4_ENST00000544040.1_Missense_Mutation_p.L1117P|CHD4_ENST00000544484.1_Missense_Mutation_p.L1121P|CHD4_ENST00000357008.2_Missense_Mutation_p.L1124P			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1124	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCGAGTGGAAAGCAAGAAGCA	0.428													17	54					0	0	1	0	0	G	6697558	A	G	6697558	3	3	25	1	0	0	0	0	1	0	0	0	3349	72	3	4	2439	4	CHD4	12	6697558	Missense_Mutation	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08		6697558	127154337	40	2511										
CHD4	1108	broad.mit.edu	37	chr12	6710697	6710697	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ttttggcagcaatgaggggtCtggtggagaaatgcacaaga	15	5	1	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr12:6710697C>T	ENST00000309577.6	-	6	721		c.e6-1		CHD4_ENST00000544040.1_Splice_Site|CHD4_ENST00000544484.1_Splice_Site|CHD4_ENST00000357008.2_Splice_Site			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AATGAGGGGTCTGGTGGAGAA	0.438													130	125					0	0	1	0	0	T	6710697	C	T	6710697	5	4	25	1	0	0	0	0	0	0	1	0	3349	927	32	3	5321	3	CHD4	12	6710697	Splice_Site	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	13139	6710697	127141198	41	2512										
CBX5	23468	broad.mit.edu	37	chr12	54645939	54645939	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tcaccctccttcatcttcttAtactttttcataaattcaga	1	12	6	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr12:54645939A>T	ENST00000209875.4	-	3	346	c.210T>A	c.(208-210)taT>taA	p.Y70*	CBX5_ENST00000550411.1_Nonsense_Mutation_p.Y70*|CBX5_ENST00000439541.2_Nonsense_Mutation_p.Y70*	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5	70	Chromo 1.				blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						TCATCTTCTTATACTTTTTCA	0.363													14	59					0	0	1	0	0	T	54645939	A	T	54645939	4	4	25	1	0	0	0	0	0	1	0	0	2739	456	16	4	377	4	CBX5	12	54645939	Nonsense_Mutation	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	47935242	54645939	79205956	42	2513										
ANO4	121601	broad.mit.edu	37	chr12	101295475	101295475	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gcgtttgcaaatccatcaacGgcgaagtgtggcaagccgcc	12	12	1	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr12:101295475G>T	ENST00000538618.1	+	4	410	c.410G>T	c.(409-411)cGg>cTg	p.R137L	ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000392977.3_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ATCCATCAACGGCGAAGTGTG	0.502										HNSCC(74;0.22)			44	26					1.52319e-26	1.68566e-26	1	1	0	T	101295475	G	T	101295475	3	4	25	1	0	0	0	0	1	0	0	0	693	1131	39	5		5	ANO4	12	101295475	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	46649536	101295475	32556420	43	2514										
NOVA1	4857	broad.mit.edu	37	chr14	26949251	26949251	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gactggttctgtcttggccaCattttggggcatttctcgaa	11	9	3	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr14:26949251C>T	ENST00000539517.2	-	3	696	c.379G>A	c.(379-381)Gtg>Atg	p.V127M	NOVA1_ENST00000344429.5_Missense_Mutation_p.V127M|NOVA1_ENST00000547619.1_Missense_Mutation_p.V127M|NOVA1_ENST00000465357.2_Missense_Mutation_p.V127M|NOVA1_ENST00000574031.1_Missense_Mutation_p.V127M|NOVA1_ENST00000267422.7_Missense_Mutation_p.V5M	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	130					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		GTCTTGGCCACATTTTGGGGC	0.438													13	48					0	0	1	0	0	T	26949251	C	T	26949251	3	4	25	1	0	0	0	0	1	0	0	0	10600	478	17	3	1187	3	NOVA1	14	26949251	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		26949251	80400289	44	2515										
ARHGAP5	394	broad.mit.edu	37	chr14	32562648	32562648	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tgtattctttatctcagtatCatcggcaaactgaggtcttt	7	8	4	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr14:32562648C>A	ENST00000345122.3	+	2	3088	c.2773C>A	c.(2773-2775)Cat>Aat	p.H925N	ARHGAP5_ENST00000556611.1_Missense_Mutation_p.H925N|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.H925N|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.H925N	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	925					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATCTCAGTATCATCGGCAAAC	0.323													21	17					3.62473e-10	3.95859e-10	1	1	0	A	32562648	C	A	32562648	3	1	25	1	0	0	0	0	1	0	0	0	883	826	29	2	2775	2	ARHGAP5	14	32562648	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	5613397	32562648	74786892	45	2516										
PRPF8	10594	broad.mit.edu	37	chr17	1563260	1563260	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	attgtctccttttgtactgtCtcaatttccagtgcatcaag	6	10	3	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr17:1563260C>T	ENST00000572621.1	-	30	5086	c.4821G>A	c.(4819-4821)gaG>gaA	p.E1607E	PRPF8_ENST00000304992.6_Silent_p.E1607E			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1607						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TTTGTACTGTCTCAATTTCCA	0.413													10	106					0	0	1	0	0	T	1563260	C	T	1563260	2	4	25	1	0	0	0	0	0	0	0	1	12626	912	32	3		3	PRPF8	17	1563260	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		1563260	79631950	46	2517										
TP53	7157	broad.mit.edu	37	chr17	7577498	7577498	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gggtggcaagtggctcctgaCctggagtcttccagtgtgat	15	9	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr17:7577498C>T	ENST00000420246.2	-	7	915		c.e7+1		TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(29)|p.0?(8)|p.E258fs*71(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGCTCCTGACCTGGAGTCTT	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	55					0	0	1	0	0	T	7577498	C	T	7577498	5	4	25	1	0	0	0	0	0	0	1	0	16441	521	18	3	507	3	TP53	17	7577498	Splice_Site	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	6014238	7577498	73617712	47	2518										
TP53	7157	broad.mit.edu	37	chr17	7578382	7578382	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gctgctcaccatcgctatctGagcagcgctcatggtggggg	14	12	3	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr17:7578382G>C	ENST00000420246.2	-	5	680	c.548C>G	c.(547-549)tCa>tGa	p.S183*	TP53_ENST00000359597.4_Nonsense_Mutation_p.S183*|TP53_ENST00000269305.4_Nonsense_Mutation_p.S183*|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000455263.2_Nonsense_Mutation_p.S183*|TP53_ENST00000413465.2_Nonsense_Mutation_p.S183*|TP53_ENST00000445888.2_Nonsense_Mutation_p.S183*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	183	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		S -> L (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S183*(29)|p.0?(8)|p.H178_S183delHHERCS(3)|p.R174fs*24(3)|p.?(2)|p.S183L(2)|p.S51*(2)|p.S90*(2)|p.V173fs*59(2)|p.H85_S90delHHERCS(1)|p.E180_S183del(1)|p.H46_S51delHHERCS(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R81fs*24(1)|p.D184fs*4(1)|p.R42fs*24(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCGCTATCTGAGCAGCGCTC	0.647		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			48	40					0	0	1	0	0	C	7578382	G	C	7578382	4	2	25	1	0	0	0	0	0	1	0	0	16441	1294	45	2	750	2	TP53	17	7578382	Nonsense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	884	7578382	73616828	48	2519										
MAPK7	5598	broad.mit.edu	37	chr17	19284178	19284178	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tgaacatcagtacttcatgaCtgagtatgtggccacgcgct	10	10	2	3			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr17:19284178C>A	ENST00000308406.5	+	4	1042	c.656C>A	c.(655-657)aCt>aAt	p.T219N	MAPK7_ENST00000395604.3_Missense_Mutation_p.T219N|MAPK7_ENST00000299612.7_Missense_Mutation_p.T80N|MAPK7_ENST00000571657.1_Intron|MAPK7_ENST00000395602.4_Missense_Mutation_p.T219N	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	219	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					TACTTCATGACTGAGTATGTG	0.527													4	71					0.00024832	0.000257632	1	1	0	A	19284178	C	A	19284178	3	1	25	1	0	0	0	0	1	0	0	0	9331	565	20	5	666	5	MAPK7	17	19284178	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	11705796	19284178	61911032	49	2520										
WNT9B	7484	broad.mit.edu	37	chr17	44953734	44953734	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gccaggtgctgaaactgcgcTatgactcggctgtcaaggtg	14	10	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr17:44953734T>A	ENST00000393461.2	+	4	777	c.724T>A	c.(724-726)Tat>Aat	p.Y242N	WNT9B_ENST00000290015.2_Missense_Mutation_p.Y242N			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	242					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GAAACTGCGCTATGACTCGGC	0.647													37	46					0	0	1	0	0	A	44953734	T	A	44953734	3	1	25	1	0	0	0	0	1	0	0	0	17458	1522	53	4	738	4	WNT9B	17	44953734	Missense_Mutation	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08	25669556	44953734	36241476	50	2521										
SOX9	6662	broad.mit.edu	37	chr17	70120195	70120195	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cagcgaacgcacatcaagacGgagcagctgagccccagcca	11	15	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr17:70120195G>A	ENST00000245479.2	+	3	1569	c.1197G>A	c.(1195-1197)acG>acA	p.T399T		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	399					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			ACATCAAGACGGAGCAGCTGA	0.682													10	175					0	0	1	0	0	A	70120195	G	A	70120195	2	1	25	1	0	0	0	0	0	0	0	1	15011	1103	39	1		1	SOX9	17	70120195	Silent	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08	25166461	70120195	11075015	51	2522										
MAPK4	5596	broad.mit.edu	37	chr18	48190668	48190668	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	acatggagaccgacctggcaCgcctgctggagcagggcacg	15	13	0	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr18:48190668C>T	ENST00000400384.2	+	2	1376	c.340C>T	c.(340-342)Cgc>Tgc	p.R114C	MAPK4_ENST00000587823.1_Intron|MAPK4_ENST00000592595.1_Missense_Mutation_p.R114C|MAPK4_ENST00000588540.1_Missense_Mutation_p.R114C|MAPK4_ENST00000540640.1_Intron	NM_002747.3	NP_002738.2	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	114	Protein kinase.				cell cycle		ATP binding|MAP kinase activity	p.R114C(1)		lung(4)|skin(3)|upper_aerodigestive_tract(1)	8		Colorectal(6;0.0297)		Colorectal(21;0.156)		CGACCTGGCACGCCTGCTGGA	0.612													44	55					0	0	1	0	0	T	48190668	C	T	48190668	3	4	25	1	0	0	0	0	1	0	0	0	9329	536	19	1	342	1	MAPK4	18	48190668	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		48190668	29886580	52	2523										
VPS4B	9525	broad.mit.edu	37	chr18	61067363	61067363	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cttgaaccacagagagaatcAatttcatcaatgaagataat	6	7	3	5			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr18:61067363A>C	ENST00000238497.5	-	7	911	c.708T>G	c.(706-708)atT>atG	p.I236M	VPS4B_ENST00000591383.1_5'UTR	NM_004869.3	NP_004860.2	O75351	VPS4B_HUMAN	vacuolar protein sorting 4 homolog B (S. cerevisiae)	236					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			breast(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	13						AGAGAGAATCAATTTCATCAA	0.343													26	26					0	0	1	0	0	C	61067363	A	C	61067363	3	2	25	1	0	0	0	0	1	0	0	0	17272	126	5	4	646	4	VPS4B	18	61067363	Missense_Mutation	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	12876695	61067363	17009885	53	2524										
ZNF77	58492	broad.mit.edu	37	chr19	2934121	2934121	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	gttctcgaagagacgagtaaCaagtgaacgcttttccgcaa	10	9	1	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr19:2934121C>T	ENST00000314531.4	-	4	1096	c.1004G>A	c.(1003-1005)tGt>tAt	p.C335Y		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		AGACGAGTAACAAGTGAACGC	0.488													26	7					0	0	1	0	0	T	2934121	C	T	2934121	3	4	25	1	0	0	0	0	1	0	0	0	18191	478	17	3	637	3	ZNF77	19	2934121	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08		2934121	56194862	54	2525										
KDM4B	23030	broad.mit.edu	37	chr19	5137981	5137981	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ctgccctcccaggtggatccAcgtgatctgtgccatcgcag	11	15	1	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr19:5137981A>C	ENST00000159111.4	+	18	2668	c.2450A>C	c.(2449-2451)cAc>cCc	p.H817P	KDM4B_ENST00000536461.1_Missense_Mutation_p.H851P	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	817					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						AGGTGGATCCACGTGATCTGT	0.672													5	13					0	0	1	0	0	C	5137981	A	C	5137981	3	2	25	1	0	0	0	0	1	0	0	0	8172	159	6	4	2512	4	KDM4B	19	5137981	Missense_Mutation	SNP	A	TCGA-N8-A4PI-01A-21D-A28R-08	2203860	5137981	53991002	55	2526										
RYR1	6261	broad.mit.edu	37	chr19	38976497	38976497	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	tccatgctctctgaatacatCgtgcccctcacgcctgagac	7	16	2	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr19:38976497C>T	ENST00000355481.4	+	34	5333	c.5202C>T	c.(5200-5202)atC>atT	p.I1734I	RYR1_ENST00000360985.3_Silent_p.I1734I|RYR1_ENST00000359596.3_Silent_p.I1734I	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1734	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGAATACATCGTGCCCCTCA	0.632													48	56					0	0	1	0	0	T	38976497	C	T	38976497	2	4	25	1	0	0	0	0	0	0	0	1	13819	874	31	1		1	RYR1	19	38976497	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	33838516	38976497	20152486	56	2527										
ZNF667	63934	broad.mit.edu	37	chr19	56953959	56953959	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	ttcttccctgaatgccctttCttaggttttactaggactga	7	10	2	2			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr19:56953959C>G	ENST00000504904.3	-	7	1124	c.405G>C	c.(403-405)aaG>aaC	p.K135N	ZNF667_ENST00000292069.6_Missense_Mutation_p.K135N|ZNF667_ENST00000342634.3_Missense_Mutation_p.K263N|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		AATGCCCTTTCTTAGGTTTTA	0.393													47	50					0	0	1	0	0	G	56953959	C	G	56953959	3	3	25	1	0	0	0	0	1	0	0	0	18130	912	32	2	1431	2	ZNF667	19	56953959	Missense_Mutation	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	17977462	56953959	2175024	57	2528										
SYCP2	10388	broad.mit.edu	37	chr20	58448922	58448922	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cattctcaccaaaaacagtgGtcgtggaattggtgaacaac	9	9	1	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr20:58448922G>A	ENST00000357552.3	-	35	3769	c.3544C>T	c.(3544-3546)Cca>Tca	p.P1182S	SYCP2_ENST00000371001.2_Missense_Mutation_p.P1182S			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1182					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AAAAACAGTGGTCGTGGAATT	0.338													9	27					0	0	1	0	0	A	58448922	G	A	58448922	3	1	25	1	0	0	0	0	1	0	0	0	15488	1261	44	3	1092	3	SYCP2	20	58448922	Missense_Mutation	SNP	G	TCGA-N8-A4PI-01A-21D-A28R-08		58448922	4576598	58	2529										
BAGE2	85319	broad.mit.edu	37	chr21	11065298	11065299	+	RNA	INS	-	-	AGC													0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	taataatagataacaaatagINSagcagcatttcaaggccctc					rs56754608		TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr21:11065298_11065299insAGC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ataacaaataGAGCAGCATTTC	0.337													4	4	---	---	---	---						AGC	11065299	-	AGC	11065298	6	5	25	0	1	1	1	0	0	0	0	0	1290	957	33	0		0	BAGE2	21	11065298	RNA	INS	-	TCGA-N8-A4PI-01A-21D-A28R-08		11065298	37064597	59	2530										
BAGE2	85319	broad.mit.edu	37	chr21	11083997	11083998	+	RNA	INS	-	-	GG													0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	catctatatatgatttgtgtINSttgtgtgtttgtgtgtgtgt					rs60923226		TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr21:11083997_11083998insGG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		atgatttgtgtttgtgtgtttg	0.277													2	4	---	---	---	---						GG	11083998	-	GG	11083997	6	5	25	0	1	1	1	0	0	0	0	0	1290	1740	60	0		0	BAGE2	21	11083997	RNA	INS	-	TCGA-N8-A4PI-01A-21D-A28R-08	18699	11083997	37045898	60	2531										
BAGE2	85319	broad.mit.edu	37	chr21	11089518	11089519	+	RNA	INS	-	-	A													0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	acagagcgagactctgtctcINSaaaaaaacagaaacaaacga							TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr21:11089518_11089519insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gactctgtctcaaaaaaacaga	0.48													8	9	---	---	---	---						A	11089519	-	A	11089518	6	5	25	0	1	1	1	0	0	0	0	0	1290	841	29	0		0	BAGE2	21	11089518	RNA	INS	-	TCGA-N8-A4PI-01A-21D-A28R-08	5521	11089518	37040377	61	2532										
COL6A2	0	broad.mit.edu	37	chr21	47552223	47552223	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cgtggcggggcccggaggcaCgcagagctgtccttcgtgtt	17	12	0	1			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chr21:47552223C>T	ENST00000300527.4	+	28	2921	c.2817C>T	c.(2815-2817)caC>caT	p.H939H		NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	939	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCCGGAGGCACGCAGAGCTGT	0.657													13	17					0	0	1	0	0	T	47552223	C	T	47552223	2	4	25	1	0	0	0	0	0	0	0	1	3723	535	19	1		1	COL6A2	21	47552223	Silent	SNP	C	TCGA-N8-A4PI-01A-21D-A28R-08	36462705	47552223	577672	62	2533										
RPS6KA3	6197	broad.mit.edu	37	chrX	20185863	20185863	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	acatactttccatcatcataTacctataaatttcaacatca	0	11	4	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chrX:20185863T>C	ENST00000379565.3	-	17	1653	c.1446A>G	c.(1444-1446)gtA>gtG	p.V482V	RPS6KA3_ENST00000544447.1_Silent_p.V454V|RPS6KA3_ENST00000379548.4_Silent_p.V452V|RPS6KA3_ENST00000540702.1_Silent_p.V453V|RPS6KA3_ENST00000479809.1_5'UTR	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	482	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						CATCATCATATACCTATAAAT	0.274													3	44					0	0	1	0	0	C	20185863	T	C	20185863	2	2	25	1	0	0	0	0	0	0	0	1	13703	1393	49	4		4	RPS6KA3	23	20185863	Silent	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08		20185863	135084697	63	2534										
LONRF3	79836	broad.mit.edu	37	chrX	118109480	118109480	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.09375	6	1	1.1496138996139	2.36309523809524	0.914746543778802	0.592074592074592	1	0	cccagcgcgagcgtcgcaacTccggcacgagggcaaccgac	13	17	0	0			TCGA-N8-A4PI-01A-21D-A28R-08	TCGA-N8-A4PI-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6d1461c3-5dbf-4c2b-be33-d525dab72592	737ff135-549c-468c-9ce9-d5b4a845cf64	g.chrX:118109480T>G	ENST00000365713.2	+	1	900	c.737T>G	c.(736-738)cTc>cGc	p.L246R	LONRF3_ENST00000304778.7_Missense_Mutation_p.L246R|LONRF3_ENST00000371628.3_Missense_Mutation_p.L246R			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	246					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						GCGTCGCAACTCCGGCACGAG	0.687													10	0					0	0	1	0	0	G	118109480	T	G	118109480	3	3	25	1	0	0	0	0	1	0	0	0	8940	1551	54	4	739	4	LONRF3	23	118109480	Missense_Mutation	SNP	T	TCGA-N8-A4PI-01A-21D-A28R-08	97923617	118109480	37161080	64	2535										
USP48	84196	broad.mit.edu	37	chr1	22073590	22073590	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cacataaggctccatatccaAaatttctgagaagccaatgt	6	10	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:22073590A>G	ENST00000308271.9	-	8	1609	c.961T>C	c.(961-963)Ttg>Ctg	p.L321L	USP48_ENST00000421625.2_Silent_p.L321L|USP48_ENST00000529637.1_Silent_p.L321L|USP48_ENST00000400301.1_Silent_p.L321L	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	321					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TCCATATCCAAAATTTCTGAG	0.328													4	12					0	0	1	0	0	G	22073590	A	G	22073590	2	3	26	1	0	0	0	0	0	0	0	1	17138	11	1	4		4	USP48	1	22073590	Silent	SNP	A	TCGA-N8-A4PL-01A-11D-A28R-08		22073590	227177031	1	2536										
LYPLA2	11313	broad.mit.edu	37	chr1	24119221	24119226	+	In_Frame_Del	DEL	GTGTCT	GTGTCT	-													0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tgctcaccgatgctgccaccGtgtctggagctgagcgggaa							TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:24119221_24119226delGTGTCT	ENST00000374514.3	+	2	356_361	c.49_54delGTGTCT	c.(49-54)del	p.VS17del	LYPLA2_ENST00000400061.1_In_Frame_Del_p.VS17del|LYPLA2_ENST00000374502.3_In_Frame_Del_p.VS17del|LYPLA2_ENST00000495365.1_3'UTR|LYPLA2_ENST00000374503.3_In_Frame_Del_p.VS17del|LYPLA2_ENST00000374505.2_In_Frame_Del_p.VS17del	NM_007260.2	NP_009191.1	O95372	LYPA2_HUMAN	lysophospholipase II	17					fatty acid metabolic process	cytoplasm	hydrolase activity			endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		TGCTGCCACCGTGTCTGGAGCTGAGC	0.65													20	73	---	---	---	---						-	24119226	GTGTCT	-	24119221	7	5	26	1	0	1	0	1	0	0	0	0	9162	1145	40	0	51	0	LYPLA2	1	24119221	In_Frame_Del	DEL	GTGTCT	TCGA-N8-A4PL-01A-11D-A28R-08	2045631	24119221	225131400	2	2537										
CYP4Z1	199974	broad.mit.edu	37	chr1	47533227	47533227	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gctgctgatcctcctctgcaTgtctctgctgctgtttcagg	10	13	3	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:47533227T>A	ENST00000334194.3	+	1	68	c.65T>A	c.(64-66)aTg>aAg	p.M22K		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	22						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						CTCCTCTGCATGTCTCTGCTG	0.552													21	19					0	0	1	0	0	A	47533227	T	A	47533227	3	1	26	1	0	0	0	0	1	0	0	0	4217	1464	51	4	67	4	CYP4Z1	1	47533227	Missense_Mutation	SNP	T	TCGA-N8-A4PL-01A-11D-A28R-08	23414006	47533227	201717394	3	2538										
PIP5K1A	8394	broad.mit.edu	37	chr1	151205104	151205104	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ctattctatgtgtccagcgaCgatgagttcattattaagac	8	8	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:151205104C>T	ENST00000409426.1	+	6	973	c.528C>T	c.(526-528)gaC>gaT	p.D176D	PIP5K1A_ENST00000368890.4_Silent_p.D175D|PIP5K1A_ENST00000368888.4_Silent_p.D188D|PIP5K1A_ENST00000441902.2_Silent_p.D176D			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	188	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGTCCAGCGACGATGAGTTCA	0.473													11	42					0	0	1	0	0	T	151205104	C	T	151205104	2	4	26	1	0	0	0	0	0	0	0	1	11986	535	19	1		1	PIP5K1A	1	151205104	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	103671877	151205104	98045517	4	2539										
ARHGAP30	257106	broad.mit.edu	37	chr1	161017791	161017791	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cttgagcctcagtcctttggCggtcccgggctagggccaca	13	14	1	1	rs140467510		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:161017791C>T	ENST00000368013.3	-	12	3340	c.3020G>A	c.(3019-3021)cGc>cAc	p.R1007H	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.R796H|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.R830H	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	1007					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGTCCTTTGGCGGTCCCGGGC	0.582													4	105					0	0	1	0	0	T	161017791	C	T	161017791	3	4	26	1	0	0	0	0	1	0	0	0	876	768	27	1	289	1	ARHGAP30	1	161017791	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	9812687	161017791	88232830	5	2540										
ARHGAP30	257106	broad.mit.edu	37	chr1	161019440	161019440	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	agtcgtctgggcctgagtctGccaggggacttgaggctgga	17	9	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:161019440G>T	ENST00000368013.3	-	11	1780	c.1460C>A	c.(1459-1461)gCa>gAa	p.A487E	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.A487E|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.A310E	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	487					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCCTGAGTCTGCCAGGGGACT	0.557													18	83					1.33834e-09	1.4454e-09	1	1	0	T	161019440	G	T	161019440	3	4	26	1	0	0	0	0	1	0	0	0	876	1319	46	5	1853	5	ARHGAP30	1	161019440	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	1649	161019440	88231181	6	2541										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185268857	185268857	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ctcaccattaagaacagccaCtccagctcctcgcctagcca	5	18	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:185268857C>T	ENST00000367498.3	-	14	2282	c.1660G>A	c.(1660-1662)Gtg>Atg	p.V554M	IVNS1ABP_ENST00000459929.1_5'UTR|IVNS1ABP_ENST00000392007.3_Missense_Mutation_p.V336M	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	554					interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						AGAACAGCCACTCCAGCTCCT	0.418													25	99					0	0	1	0	0	T	185268857	C	T	185268857	3	4	26	1	0	0	0	0	1	0	0	0	7973	565	20	3	276	3	IVNS1ABP	1	185268857	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	24249417	185268857	63981764	7	2542										
LGR6	59352	broad.mit.edu	37	chr1	202245457	202245457	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cctagatgccaacctcatctCcctggtcccggagaggagct	10	15	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:202245457C>G	ENST00000367278.3	+	5	541	c.452C>G	c.(451-453)tCc>tGc	p.S151C	LGR6_ENST00000255432.7_Missense_Mutation_p.S99C|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000439764.2_Intron	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	151						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						AACCTCATCTCCCTGGTCCCG	0.617													12	47					0	0	1	0	0	G	202245457	C	G	202245457	3	3	26	1	0	0	0	0	1	0	0	0	8797	855	30	2	617	2	LGR6	1	202245457	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	16976600	202245457	47005164	8	2543										
USH2A	7399	broad.mit.edu	37	chr1	216246463	216246463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	aaaaggctggagaccaccctCgtaaacactctgctcttttc	7	13	2	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr1:216246463C>T	ENST00000366943.2	-	28	6138	c.5752G>A	c.(5752-5754)Gag>Aag	p.E1918K	RP11-22M7.2_ENST00000430890.1_RNA|RP11-22M7.2_ENST00000445619.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.E1918K|RP11-22M7.2_ENST00000446411.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1918	Fibronectin type-III 5.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGACCACCCTCGTAAACACTC	0.478										HNSCC(13;0.011)			14	16					0	0	1	0	0	T	216246463	C	T	216246463	3	4	26	1	0	0	0	0	1	0	0	0	17095	893	31	1	10036	1	USH2A	1	216246463	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	14001006	216246463	33004158	9	2544										
POTEF	728378	broad.mit.edu	37	chr2	130832627	130832627	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ttagggttcagggtggcctcGgtcagcaggacggggtgctc	18	9	2	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr2:130832627G>A	ENST00000357462.5	-	15	2511	c.2418C>T	c.(2416-2418)acC>acT	p.T806T	POTEF_ENST00000409914.2_Silent_p.T806T			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	806	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GGGTGGCCTCGGTCAGCAGGA	0.587													33	221					0	0	1	0	0	A	130832627	G	A	130832627	2	1	26	1	0	0	0	0	0	0	0	1	12311	1103	39	1		1	POTEF	2	130832627	Silent	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		130832627	112366746	10	2545										
OSBPL6	114880	broad.mit.edu	37	chr2	179213992	179213992	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tcaccagttcgcttgcattcCtccaaccccaacctttgtgc	5	17	1	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr2:179213992C>A	ENST00000190611.4	+	12	1405	c.1029C>A	c.(1027-1029)tcC>tcA	p.S343S	OSBPL6_ENST00000409631.1_Silent_p.S343S|OSBPL6_ENST00000409045.3_Silent_p.S312S|OSBPL6_ENST00000392505.2_Silent_p.S368S|OSBPL6_ENST00000359685.3_Silent_p.S343S|OSBPL6_ENST00000357080.4_Silent_p.S312S|OSBPL6_ENST00000315022.2_Silent_p.S347S	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	343					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GCTTGCATTCCTCCAACCCCA	0.438													70	82					2.47556e-37	2.82423e-37	1	1	0	A	179213992	C	A	179213992	2	1	26	1	0	0	0	0	0	0	0	1	11327	668	24	5		5	OSBPL6	2	179213992	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	48381365	179213992	63985381	11	2546										
TTLL4	9654	broad.mit.edu	37	chr2	219612366	219612366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gcggcagcaagtttgacctgCggatctatgtttatgtcact	11	9	2	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr2:219612366C>T	ENST00000392102.1	+	11	2636	c.2296C>T	c.(2296-2298)Cgg>Tgg	p.R766W	TTLL4_ENST00000258398.4_Missense_Mutation_p.R766W|TTLL4_ENST00000442769.1_Missense_Mutation_p.R702W|TTLL4_ENST00000457313.1_Missense_Mutation_p.R601W	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	766	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		GTTTGACCTGCGGATCTATGT	0.498													19	73					0	0	1	0	0	T	219612366	C	T	219612366	3	4	26	1	0	0	0	0	1	0	0	0	16790	759	27	1	2330	1	TTLL4	2	219612366	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	40398374	219612366	23587007	12	2547										
CAND2	23066	broad.mit.edu	37	chr3	12858734	12858734	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gcaggccctggtagggacccGtcccccgtgtgtggactatg	15	13	0	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr3:12858734G>C	ENST00000456430.2	+	10	2344	c.2303G>C	c.(2302-2304)cGt>cCt	p.R768P	CAND2_ENST00000295989.5_Missense_Mutation_p.R675P	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	768					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GTAGGGACCCGTCCCCCGTGT	0.637													16	26					0	0	1	0	0	C	12858734	G	C	12858734	3	2	26	1	0	0	0	0	1	0	0	0	2634	1145	40	5	2341	5	CAND2	3	12858734	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		12858734	185163696	13	2548										
SLMAP	7871	broad.mit.edu	37	chr3	57882247	57882247	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tttcttggtagaaaatcagaCaagagcaaaagaatctgatt	8	5	3	5			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr3:57882247C>G	ENST00000383718.3	+	14	1405	c.1307C>G	c.(1306-1308)aCa>aGa	p.T436R	SLMAP_ENST00000416870.1_5'UTR|SLMAP_ENST00000449503.2_Missense_Mutation_p.T402R|SLMAP_ENST00000494088.1_5'UTR|SLMAP_ENST00000295951.3_Missense_Mutation_p.T423R|SLMAP_ENST00000472546.1_3'UTR|SLMAP_ENST00000295952.3_Missense_Mutation_p.T423R|SLMAP_ENST00000495364.1_5'UTR|SLMAP_ENST00000442599.2_5'UTR|SLMAP_ENST00000428312.1_Missense_Mutation_p.T440R			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	440					muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GAAAATCAGACAAGAGCAAAA	0.318													2	2					0	0	1	0	0	G	57882247	C	G	57882247	3	3	26	1	0	0	0	0	1	0	0	0	14802	478	17	5	1318	5	SLMAP	3	57882247	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	45023513	57882247	140140183	14	2549										
DOK7	285489	broad.mit.edu	37	chr4	3475359	3475359	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cggatccgctatgcgctcggCgagggtgagtgacgggggcc	19	11	0	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr4:3475359C>T	ENST00000340083.5	+	3	392	c.327C>T	c.(325-327)ggC>ggT	p.G109G	DOK7_ENST00000389653.2_Silent_p.G109G|DOK7_ENST00000507039.1_Silent_p.G109G	NM_173660.4	NP_775931.3	Q18PE1	DOK7_HUMAN	docking protein 7	109	IRS-type PTB.|PH.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			kidney(1)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	5				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		ATGCGCTCGGCGAGGGTGAGT	0.706													4	4					0	0	1	0	0	T	3475359	C	T	3475359	2	4	26	1	0	0	0	0	0	0	0	1	4729	755	27	1		1	DOK7	4	3475359	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08		3475359	187678917	15	2550										
JAKMIP1	152789	broad.mit.edu	37	chr4	6064099	6064099	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tcctggagcagggcgtaggcGcgttgcagggcctggtactc	17	11	0	0	rs149678000	byFrequency	TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr4:6064099G>A	ENST00000409021.3	-	10	1949	c.1500C>T	c.(1498-1500)cgC>cgT	p.R500R	JAKMIP1_ENST00000409831.1_Silent_p.R500R|JAKMIP1_ENST00000409371.3_Silent_p.R315R|JAKMIP1_ENST00000282924.5_Silent_p.R500R|JAKMIP1_ENST00000410077.2_Silent_p.R335R	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	500	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGGCGTAGGCGCGTTGCAGGG	0.642													20	22					0	0	1	0	0	A	6064099	G	A	6064099	2	1	26	1	0	0	0	0	0	0	0	1	7983	1074	38	1		1	JAKMIP1	4	6064099	Silent	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	2588740	6064099	185090177	16	2551										
KCNIP4	80333	broad.mit.edu	37	chr4	20760463	20760463	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cctccctgtggaaagaactgCgagtaaatctctttgaaggt	10	9	1	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr4:20760463C>T	ENST00000382148.3	-	3	600	c.264G>A	c.(262-264)tcG>tcA	p.S88S	KCNIP4_ENST00000447367.2_Silent_p.S79S|KCNIP4_ENST00000359001.5_Silent_p.S51S|KCNIP4_ENST00000509207.1_Silent_p.S51S|KCNIP4_ENST00000382149.4_5'UTR|KCNIP4_ENST00000382150.4_Silent_p.S92S|KCNIP4_ENST00000382152.2_Silent_p.S113S	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	113	EF-hand 1; degenerate.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				GAAAGAACTGCGAGTAAATCT	0.378													9	35					0	0	1	0	0	T	20760463	C	T	20760463	2	4	26	1	0	0	0	0	0	0	0	1	8085	755	27	1		1	KCNIP4	4	20760463	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	14696364	20760463	170393813	17	2552										
FAT4	79633	broad.mit.edu	37	chr4	126329626	126329626	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ggtagcagccattttagccaCggatgatgactctggtgtga	13	8	1	3	rs141773516	byFrequency	TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr4:126329626C>T	ENST00000394329.3	+	4	5610	c.5597C>T	c.(5596-5598)aCg>aTg	p.T1866M	FAT4_ENST00000335110.5_Missense_Mutation_p.T164M	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1866	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATTTTAGCCACGGATGATGAC	0.328													21	42					0	0	1	0	0	T	126329626	C	T	126329626	3	4	26	1	0	0	0	0	1	0	0	0	5724	536	19	1	5611	1	FAT4	4	126329626	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	105569163	126329626	64824650	18	2553										
PCDHB2	0	broad.mit.edu	37	chr5	140475626	140475626	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tggaccgggagaccagatccGaatacaacatcaccatcacc	8	14	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr5:140475626G>A	ENST00000194155.4	+	1	1400	c.1252G>A	c.(1252-1254)Gaa>Aaa	p.E418K		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		418	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACCAGATCCGAATACAACAT	0.517													20	68					0	0	1	0	0	A	140475626	G	A	140475626	3	1	26	1	0	0	0	0	1	0	0	0	11588	1059	37	1	1254	1	PCDHB2	5	140475626	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		140475626	40439634	19	2554										
ARAP3	64411	broad.mit.edu	37	chr5	141052393	141052393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cacgcagctccagcatgcccGtgcggaggggtcggggtggt	18	12	0	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr5:141052393G>A	ENST00000239440.4	-	8	1258	c.1193C>T	c.(1192-1194)aCg>aTg	p.T398M	ARAP3_ENST00000508305.1_Missense_Mutation_p.T320M|ARAP3_ENST00000513878.1_Missense_Mutation_p.T60M	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	398	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CAGCATGCCCGTGCGGAGGGG	0.672													15	12					0	0	1	0	0	A	141052393	G	A	141052393	3	1	26	1	0	0	0	0	1	0	0	0	837	1145	40	1	3545	1	ARAP3	5	141052393	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	576767	141052393	39862867	20	2555										
GM2A	2760	broad.mit.edu	37	chr5	150646988	150646988	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cgtctgggctgcatcaagatCgctgcctctctaaagggcat	11	12	3	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr5:150646988C>T	ENST00000357164.3	+	4	883	c.558C>T	c.(556-558)atC>atT	p.I186I		NM_000405.4|NM_001167607.1	NP_000396.2|NP_001161079.1	P17900	SAP3_HUMAN	GM2 ganglioside activator	186						lysosome|nucleolus	sphingolipid activator protein activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|upper_aerodigestive_tract(2)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCATCAAGATCGCTGCCTCTC	0.557													8	34					0	0	1	0	0	T	150646988	C	T	150646988	2	4	26	1	0	0	0	0	0	0	0	1	6525	874	31	1		1	GM2A	5	150646988	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	9594595	150646988	30268272	21	2556										
GPLD1	2822	broad.mit.edu	37	chr6	24473848	24473848	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	aaatgtaaataaacagtaccAaaatcaccagccgaatgagc	6	9	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr6:24473848A>G	ENST00000230036.1	-	6	599	c.490_splice	c.e6+1	p.F163_splice	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	163						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						AAACAGTACCAAAATCACCAG	0.353													13	17					0	0	1	0	0	G	24473848	A	G	24473848	5	3	26	1	0	0	0	0	0	0	1	0	6653	144	5	4	2154	4	GPLD1	6	24473848	Splice_Site	SNP	A	TCGA-N8-A4PL-01A-11D-A28R-08		24473848	146641219	22	2557										
OR2W1	26692	broad.mit.edu	37	chr6	29012269	29012269	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cgctggcttgcttttgacttCgttctcagcacagctttggc	10	12	1	1	rs144276666		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr6:29012269C>T	ENST00000377175.1	-	1	748	c.684G>A	c.(682-684)acG>acA	p.T228T		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T228T(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						CTTTTGACTTCGTTCTCAGCA	0.393													26	63					0	0	1	0	0	T	29012269	C	T	29012269	2	4	26	1	0	0	0	0	0	0	0	1	11079	871	31	1		1	OR2W1	6	29012269	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	4538421	29012269	142102798	23	2558										
DHX16	8449	broad.mit.edu	37	chr6	30639046	30639046	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ttttctaccactgcctttcgTggtacctgtcagtagagggg	11	10	2	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr6:30639046T>C	ENST00000376442.3	-	2	408	c.213A>G	c.(211-213)ccA>ccG	p.P71P		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	71					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CTGCCTTTCGTGGTACCTGTC	0.512													8	243					0	0	1	0	0	C	30639046	T	C	30639046	2	2	26	1	0	0	0	0	0	0	0	1	4530	1683	59	4		4	DHX16	6	30639046	Silent	SNP	T	TCGA-N8-A4PL-01A-11D-A28R-08	1626777	30639046	140476021	24	2559										
CUL9	23113	broad.mit.edu	37	chr6	43164458	43164458	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	caccacactctgggagaccaGattataacccaagagctgag	9	12	1	4			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr6:43164458G>T	ENST00000252050.4	+	11	2745	c.2661G>T	c.(2659-2661)caG>caT	p.Q887H	CUL9_ENST00000372647.2_Missense_Mutation_p.Q887H|CUL9_ENST00000354495.3_Missense_Mutation_p.Q777H	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	887					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						TGGGAGACCAGATTATAACCC	0.517													4	99					0.150653	0.150653	1	1	0	T	43164458	G	T	43164458	3	4	26	1	0	0	0	0	1	0	0	0	4084	933	33	2	2699	2	CUL9	6	43164458	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	12525412	43164458	127950609	25	2560										
AARS2	57505	broad.mit.edu	37	chr6	44272877	44272877	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ggcgctgcagctccccaagcGcatggacatcaagccacaat	10	15	1	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr6:44272877G>A	ENST00000244571.4	-	11	1495	c.1493C>T	c.(1492-1494)gCg>gTg	p.A498V	TMEM151B_ENST00000438774.2_Intron	NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	498					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CTCCCCAAGCGCATGGACATC	0.607											OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	71					0	0	1	0	0	A	44272877	G	A	44272877	3	1	26	1	0	0	0	0	1	0	0	0	20	1087	38	1	1512	1	AARS2	6	44272877	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	1108419	44272877	126842190	26	2561										
HUS1	3364	broad.mit.edu	37	chr7	48016344	48016344	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tacatcaggatctgggaccaCcggttcttgtaagtccttcc	9	12	3	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr7:48016344C>A	ENST00000258774.5	-	4	471	c.448G>T	c.(448-450)Gtg>Ttg	p.V150L	HUS1_ENST00000432325.1_Missense_Mutation_p.V129L	NM_004507.3	NP_004498.1	O60921	HUS1_HUMAN	HUS1 checkpoint homolog (S. pombe)	150					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|prostate(1)	13		Breast(660;0.00139)				TCTGGGACCACCGGTTCTTGT	0.458								Direct reversal of damage;Other conserved DNA damage response genes					24	50					8.24728e-16	9.1511e-16	1	1	0	A	48016344	C	A	48016344	3	1	26	1	0	0	0	0	1	0	0	0	7502	507	18	5	414	5	HUS1	7	48016344	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08		48016344	111122319	27	2562										
FKBP6	8468	broad.mit.edu	37	chr7	72744195	72744195	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gctgggccttctgagcatgcGgagaggagagctggccaggt	18	9	1	3	rs3950376		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr7:72744195G>A	ENST00000252037.4	+	4	377	c.308G>A	c.(307-309)cGg>cAg	p.R103Q	FKBP6_ENST00000431982.2_Missense_Mutation_p.R98Q|FKBP6_ENST00000413573.2_Missense_Mutation_p.R73Q	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	103	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	p.R103Q(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				CTGAGCATGCGGAGAGGAGAG	0.537													3	27					0	0	1	0	0	A	72744195	G	A	72744195	3	1	26	1	0	0	0	0	1	0	0	0	5944	1116	39	1	368	1	FKBP6	7	72744195	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	24727851	72744195	86394468	28	2563										
SLCO5A1	81796	broad.mit.edu	37	chr8	70744166	70744166	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	agtccttcggacaggccggaGgctccaaagtggcggtggag	17	10	0	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr8:70744166G>A	ENST00000260126.3	-	2	1449	c.743C>T	c.(742-744)cCt>cTt	p.P248L	SLCO5A1_ENST00000528658.1_5'UTR|SLCO5A1_ENST00000530307.1_Missense_Mutation_p.P248L|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.P248L	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	248						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ACAGGCCGGAGGCTCCAAAGT	0.572													29	15					0	0	1	0	0	A	70744166	G	A	70744166	3	1	26	1	0	0	0	0	1	0	0	0	14785	1000	35	3	1839	3	SLCO5A1	8	70744166	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		70744166	75619856	29	2564										
SLC26A7	115111	broad.mit.edu	37	chr8	92346559	92346559	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ttgaaaacatcaagtctgtgCgactggaagcattgctttta	9	7	2	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr8:92346559C>A	ENST00000276609.3	+	6	918	c.679C>A	c.(679-681)Cga>Aga	p.R227R	SLC26A7_ENST00000523719.1_Silent_p.R227R|SLC26A7_ENST00000309536.2_Silent_p.R227R	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	227						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CAAGTCTGTGCGACTGGAAGC	0.328													7	22					0.000274275	0.000288523	1	1	0	A	92346559	C	A	92346559	2	1	26	1	0	0	0	0	0	0	0	1	14576	760	27	5		5	SLC26A7	8	92346559	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	21602393	92346559	54017463	30	2565										
GEM	2669	broad.mit.edu	37	chr8	95262747	95262747	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gccctcaaacagctccttcaCgttgtgctggacagctgcag	10	14	2	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr8:95262747C>T	ENST00000297596.2	-	5	946	c.682G>A	c.(682-684)Gtg>Atg	p.V228M	GEM_ENST00000396194.2_Missense_Mutation_p.V228M	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	228					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			AGCTCCTTCACGTTGTGCTGG	0.562													8	36					0	0	1	0	0	T	95262747	C	T	95262747	3	4	26	1	0	0	0	0	1	0	0	0	6370	536	19	1	212	1	GEM	8	95262747	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	2916188	95262747	51101275	31	2566										
DENND3	22898	broad.mit.edu	37	chr8	142175305	142175305	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gtcttagacacctacatgttCcattcttttcttaaagcccg	5	12	3	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr8:142175305C>T	ENST00000519811.1	+	11	1540	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	DENND3_ENST00000262585.2_Silent_p.F410F|DENND3_ENST00000424248.1_Silent_p.F358F			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	410										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTACATGTTCCATTCTTTTC	0.567													44	51					0	0	1	0	0	T	142175305	C	T	142175305	2	4	26	1	0	0	0	0	0	0	0	1	4460	854	30	3		3	DENND3	8	142175305	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	46912558	142175305	4188717	32	2567										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18635979	18635979	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	caattccctatggaagtagaCatattcgccttgtcttaaaa	6	9	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr9:18635979C>A	ENST00000380548.4	+	6	979	c.640C>A	c.(640-642)Cat>Aat	p.H214N	ADAMTSL1_ENST00000327883.7_Missense_Mutation_p.H214N|ADAMTSL1_ENST00000380566.4_Missense_Mutation_p.H214N|ADAMTSL1_ENST00000276935.6_Missense_Mutation_p.H214N	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	214						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGGAAGTAGACATATTCGCCT	0.348													28	20					1.32181e-22	1.48704e-22	1	1	0	A	18635979	C	A	18635979	3	1	26	1	0	0	0	0	1	0	0	0	273	478	17	5	662	5	ADAMTSL1	9	18635979	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08		18635979	122577452	33	2568										
DNLZ	728489	broad.mit.edu	37	chr9	139257510	139257510	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ggtggttctggcagccggggCaggtcacaatgaccacgcct	15	12	2	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr9:139257510C>T	ENST00000371738.3	-	2	373	c.299G>A	c.(298-300)tGc>tAc	p.C100Y	DNLZ_ENST00000371739.3_Intron	NM_001080849.1	NP_001074318.1	Q5SXM8	DNLZ_HUMAN	DNL-type zinc finger	100							metal ion binding			central_nervous_system(1)|prostate(1)	2		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.42e-06)|Epithelial(140;3.3e-06)		GCAGCCGGGGCAGGTCACAAT	0.617													32	56					0	0	1	0	0	T	139257510	C	T	139257510	3	4	26	1	0	0	0	0	1	0	0	0	4696	710	25	3	245	3	DNLZ	9	139257510	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	120621531	139257510	1955921	34	2569										
KIF11	3832	broad.mit.edu	37	chr10	94369210	94369210	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gatgaagtctatcaaattttAgaaaagggggcagcaaaaag	11	4	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr10:94369210A>C	ENST00000260731.3	+	6	732	c.642A>C	c.(640-642)ttA>ttC	p.L214F		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	214	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATCAAATTTTAGAAAAGGGGG	0.373													16	185					0	0	1	0	0	C	94369210	A	C	94369210	3	2	26	1	0	0	0	0	1	0	0	0	8313	417	15	4	664	4	KIF11	10	94369210	Missense_Mutation	SNP	A	TCGA-N8-A4PL-01A-11D-A28R-08		94369210	41165537	35	2570										
FAM160A2	84067	broad.mit.edu	37	chr11	6236077	6236077	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	accagccccgtcagcaggaaGttgacatagacggagttctg	12	11	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr11:6236077G>T	ENST00000265978.4	-	10	2680	c.2322C>A	c.(2320-2322)aaC>aaA	p.N774K	FAM160A2_ENST00000449352.2_Missense_Mutation_p.N760K|FAM160A2_ENST00000529360.1_5'UTR	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	760					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCAGCAGGAAGTTGACATAGA	0.597													21	1					1.50039e-11	1.64232e-11	1	1	0	T	6236077	G	T	6236077	3	4	26	1	0	0	0	0	1	0	0	0	5499	1020	36	5	650	5	FAM160A2	11	6236077	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		6236077	128770439	36	2571										
ARNTL	406	broad.mit.edu	37	chr11	13393792	13393792	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	aagatggggctggatgaagaCaacgaaccagacaatgaggg	15	6	0	5			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr11:13393792C>T	ENST00000389708.3	+	13	1258	c.903C>T	c.(901-903)gaC>gaT	p.D301D	ARNTL_ENST00000401424.1_Silent_p.D258D|ARNTL_ENST00000396441.3_Silent_p.D300D|ARNTL_ENST00000403290.1_Silent_p.D301D|ARNTL_ENST00000403482.3_Silent_p.D299D|ARNTL_ENST00000361003.4_Intron|ARNTL_ENST00000403510.3_Silent_p.D257D|ARNTL_ENST00000497429.1_3'UTR|ARNTL_ENST00000389707.4_Silent_p.D300D			O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear translocator-like	301					circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(11)|lung(5)|upper_aerodigestive_tract(1)	20				Epithelial(150;0.0243)		TGGATGAAGACAACGAACCAG	0.498													35	2					0	0	1	0	0	T	13393792	C	T	13393792	2	4	26	1	0	0	0	0	0	0	0	1	966	477	17	3		3	ARNTL	11	13393792	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	7157715	13393792	121612724	37	2572										
TSG101	7251	broad.mit.edu	37	chr11	18503375	18503375	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	agagcagaactgagttcttcAtccttctttttcaaaagttc	6	9	4	3			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr11:18503375A>T	ENST00000536719.1	-	9	1019	c.885T>A	c.(883-885)gaT>gaA	p.D295E	TSG101_ENST00000251968.3_Missense_Mutation_p.D295E|TSG101_ENST00000357193.3_Missense_Mutation_p.D190E			Q99816	TS101_HUMAN	tumor susceptibility 101	295					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						TGAGTTCTTCATCCTTCTTTT	0.363													10	8					0	0	1	0	0	T	18503375	A	T	18503375	3	4	26	1	0	0	0	0	1	0	0	0	16676	214	8	4	295	4	TSG101	11	18503375	Missense_Mutation	SNP	A	TCGA-N8-A4PL-01A-11D-A28R-08	5109583	18503375	116503141	38	2573										
OR5M8	219484	broad.mit.edu	37	chr11	56258788	56258788	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	agaggagaatttgtaattccCggcgactggtcagtcccagg	13	9	1	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr11:56258788C>T	ENST00000327216.2	-	1	83	c.59G>A	c.(58-60)cGg>cAg	p.R20Q		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TTGTAATTCCCGGCGACTGGT	0.483													58	5					0	0	1	0	0	T	56258788	C	T	56258788	3	4	26	1	0	0	0	0	1	0	0	0	11222	652	23	1	880	1	OR5M8	11	56258788	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	37755413	56258788	78747728	39	2574										
AHNAK	79026	broad.mit.edu	37	chr11	62300151	62300151	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	accccctttcactttaggtgCggccacatttaagtctactt	6	13	2	0	rs138061218		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr11:62300151C>T	ENST00000378024.4	-	5	2012	c.1738G>A	c.(1738-1740)Gca>Aca	p.A580T	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	580					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ACTTTAGGTGCGGCCACATTT	0.507													30	4					0	0	1	0	0	T	62300151	C	T	62300151	3	4	26	1	0	0	0	0	1	0	0	0	411	768	27	1	16054	1	AHNAK	11	62300151	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	6041363	62300151	72706365	40	2575										
B3GAT1	27087	broad.mit.edu	37	chr11	134253812	134253812	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gcagcaggcgcgcggtcagcGgcgtccggcgcggcgcatcc	18	16	1	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr11:134253812G>A	ENST00000524765.1	-	3	4927	c.383C>T	c.(382-384)cCg>cTg	p.P128L	B3GAT1_ENST00000537389.1_Missense_Mutation_p.P141L|B3GAT1_ENST00000312527.4_Missense_Mutation_p.P128L|B3GAT1_ENST00000392580.1_Missense_Mutation_p.P128L			Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	128					carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		CGCGGTCAGCGGCGTCCGGCG	0.716													8	4					0	0	1	0	0	A	134253812	G	A	134253812	3	1	26	1	0	0	0	0	1	0	0	0	1251	1116	39	1	633	1	B3GAT1	11	134253812	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	71953661	134253812	752704	41	2576										
GAPDH	2597	broad.mit.edu	37	chr12	6646101	6646101	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cataggcgagatccctccaaAatcaagtggggcgatgctgg	13	10	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr12:6646101A>C	ENST00000229239.5	+	5	918	c.252A>C	c.(250-252)aaA>aaC	p.K84N	GAPDH_ENST00000396858.1_Missense_Mutation_p.K42N|GAPDH_ENST00000396856.1_Missense_Mutation_p.K9N|GAPDH_ENST00000396859.1_Missense_Mutation_p.K84N|GAPDH_ENST00000396861.1_Missense_Mutation_p.K84N	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	84	Interaction with WARS.				gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	ATCCCTCCAAAATCAAGTGGG	0.607													148	161					0	0	1	0	0	C	6646101	A	C	6646101	3	2	26	1	0	0	0	0	1	0	0	0	6275	11	1	4	266	4	GAPDH	12	6646101	Missense_Mutation	SNP	A	TCGA-N8-A4PL-01A-11D-A28R-08		6646101	127205794	42	2577										
NOP2	4839	broad.mit.edu	37	chr12	6666174	6666174	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	accatctaagatagcagcagCtggctgttgcccctggactg	11	12	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr12:6666174C>G	ENST00000541778.1	-	16	2900	c.2412G>C	c.(2410-2412)caG>caC	p.Q804H	NOP2_ENST00000399466.2_Missense_Mutation_p.Q804H|NOP2_ENST00000322166.5_Missense_Mutation_p.Q808H|NOP2_ENST00000537442.1_Missense_Mutation_p.Q808H|NOP2_ENST00000382421.3_Missense_Mutation_p.Q841H|NOP2_ENST00000545200.1_3'UTR			P46087	NOP2_HUMAN	NOP2 nucleolar protein	808					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						ATAGCAGCAGCTGGCTGTTGC	0.567													37	35					0	0	1	0	0	G	6666174	C	G	6666174	3	3	26	1	0	0	0	0	1	0	0	0	10584	796	28	5	18	5	NOP2	12	6666174	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	20073	6666174	127185721	43	2578										
PTPN6	5777	broad.mit.edu	37	chr12	7064144	7064145	+	In_Frame_Ins	INS	-	-	GGTCAT													0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ctcagggtcacccacatcaaINSggtcatgtgcgaggtaaggc							TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr12:7064144_7064145insGGTCAT	ENST00000456013.1	+	4	745_746	c.503_504insGGTCAT	c.(502-504)agt>aGGTCATgt	p.168_168S>RSC	PTPN6_ENST00000447931.2_In_Frame_Ins_p.129_129S>RSC|PTPN6_ENST00000399448.1_In_Frame_Ins_p.170_170S>RSC|PTPN6_ENST00000318974.9_In_Frame_Ins_p.168_168S>RSC	NM_080549.3	NP_536859.1	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type 6	168	SH2 2.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|prostate(3)	18						ACCCACATCAAGGTCATGTGCG	0.653													41	77	---	---	---	---						GGTCAT	7064145	-	GGTCAT	7064144	7	5	26	1	0	1	1	0	0	0	0	0	12843	72	3	0	535	0	PTPN6	12	7064144	In_Frame_Ins	INS	-	TCGA-N8-A4PL-01A-11D-A28R-08	397970	7064144	126787751	44	2579										
AEBP2	121536	broad.mit.edu	37	chr12	19615449	19615449	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tttcttcttttgtagcataaGcagtactataatggatgtag	8	5	2	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr12:19615449G>A	ENST00000266508.9	+	2	678	c.677G>A	c.(676-678)aGc>aAc	p.S226N	AEBP2_ENST00000541908.1_5'UTR|AEBP2_ENST00000360995.4_Missense_Mutation_p.S10N|AEBP2_ENST00000398864.3_Missense_Mutation_p.S226N	NM_153207.4	NP_694939.2	Q6ZN18	AEBP2_HUMAN	AE binding protein 2	226	Interaction with RBBP4.|Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					TGTAGCATAAGCAGTACTATA	0.333													7	11					0	0	1	0	0	A	19615449	G	A	19615449	3	1	26	1	0	0	0	0	1	0	0	0	349	971	34	3	683	3	AEBP2	12	19615449	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	12551305	19615449	114236446	45	2580										
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr12:25398284C>G	ENST00000311936.3	-	2	226	c.35G>C	c.(34-36)gGt>gCt	p.G12A	KRAS_ENST00000556131.1_Missense_Mutation_p.G12A|KRAS_ENST00000256078.4_Missense_Mutation_p.G12A|KRAS_ENST00000557334.1_Missense_Mutation_p.G12A	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			9	1					0	0	1	0	0	G	25398284	C	G	25398284	3	3	26	1	0	0	0	0	1	0	0	0	8480	507	18	5	671	5	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	5782835	25398284	108453611	46	2581										
PCDH9	5101	broad.mit.edu	37	chr13	67802394	67802394	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ccagtctgtagacaaggctgGcgctggtccctgtggcagca	14	12	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr13:67802394G>A	ENST00000544246.1	-	2	870	c.179C>T	c.(178-180)gCc>gTc	p.A60V	PCDH9_ENST00000456367.1_Missense_Mutation_p.A60V|PCDH9_ENST00000377861.3_Missense_Mutation_p.A60V|PCDH9_ENST00000377865.2_Missense_Mutation_p.A60V|PCDH9_ENST00000328454.5_Missense_Mutation_p.A60V	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	60	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GACAAGGCTGGCGCTGGTCCC	0.458													18	51					0	0	1	0	0	A	67802394	G	A	67802394	3	1	26	1	0	0	0	0	1	0	0	0	11564	1203	42	3	3550	3	PCDH9	13	67802394	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		67802394	47367484	47	2582										
MYO16	23026	broad.mit.edu	37	chr13	109793236	109793236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	gcagccggaggggtcgagccCgctgtccccgcagtactcca	14	16	0	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr13:109793236C>T	ENST00000356711.2	+	32	4736	c.4610C>T	c.(4609-4611)cCg>cTg	p.P1537L	MYO16_ENST00000357550.2_Missense_Mutation_p.P1537L	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1537	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GGGTCGAGCCCGCTGTCCCCG	0.716													5	16					0	0	1	0	0	T	109793236	C	T	109793236	3	4	26	1	0	0	0	0	1	0	0	0	10111	652	23	1	4732	1	MYO16	13	109793236	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	41990842	109793236	5376642	48	2583										
OR4K2	390431	broad.mit.edu	37	chr14	20344723	20344723	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tcttttgatggctgccttacCcagatattctttctccacct	5	13	3	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr14:20344723C>A	ENST00000298642.2	+	1	333	c.297C>A	c.(295-297)acC>acA	p.T99T		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTGCCTTACCCAGATATTCT	0.413													6	152					3.59834e-05	3.83507e-05	1	1	0	A	20344723	C	A	20344723	2	1	26	1	0	0	0	0	0	0	0	1	11119	610	22	5		5	OR4K2	14	20344723	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08		20344723	87004817	49	2584										
TINF2	26277	broad.mit.edu	37	chr14	24709663	24709663	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ggcaagtcaactgggttctcCttcagagcccttccccccag	9	16	3	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr14:24709663C>T	ENST00000399423.4	-	6	1353	c.1023G>A	c.(1021-1023)aaG>aaA	p.K341K	TINF2_ENST00000538777.1_Silent_p.K127K|TINF2_ENST00000540705.1_Silent_p.K306K|TINF2_ENST00000558566.1_3'UTR|TINF2_ENST00000267415.7_Silent_p.K341K	NM_012461.2	NP_036593.2	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	341					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|telomeric DNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|prostate(1)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0185)		CTGGGTTCTCCTTCAGAGCCC	0.532									Congenital Dyskeratosis;Ataxia Pancytopenia syndrome				16	14					0	0	1	0	0	T	24709663	C	T	24709663	2	4	26	1	0	0	0	0	0	0	0	1	15982	680	24	3		3	TINF2	14	24709663	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	4364940	24709663	82639877	50	2585										
PPL	5493	broad.mit.edu	37	chr16	4949275	4949275	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	aggttgcggtcactccagtcGtactgcatgcggcccttggc	13	13	1	0	rs140083031		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr16:4949275G>A	ENST00000345988.2	-	7	806	c.717C>T	c.(715-717)taC>taT	p.Y239Y	PPL_ENST00000590782.2_Silent_p.Y237Y	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	239					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CACTCCAGTCGTACTGCATGC	0.657													15	32					0	0	1	0	0	A	4949275	G	A	4949275	2	1	26	1	0	0	0	0	0	0	0	1	12382	1140	40	1		1	PPL	16	4949275	Silent	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		4949275	85405478	51	2586										
ZFHX3	463	broad.mit.edu	37	chr16	72821810	72821810	+	Frame_Shift_Del	DEL	G	G	-													0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tgcacctttggaacaatgaaGgggtcgtagagggagtccgc							TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr16:72821810delG	ENST00000268489.5	-	10	11037	c.10365delC	c.(10363-10365)ccfs	p.P3455fs	ZFHX3_ENST00000397992.5_Frame_Shift_Del_p.P2541fs	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3455					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GAACAATGAAGGGGTCGTAGA	0.582													52	13	---	---	---	---						-	72821810	G	-	72821810	7	5	26	1	0	1	0	1	0	0	0	0	17691	987	35	0	750	0	ZFHX3	16	72821810	Frame_Shift_Del	DEL	G	TCGA-N8-A4PL-01A-11D-A28R-08	67872535	72821810	17532943	52	2587										
ALOX12	239	broad.mit.edu	37	chr17	6900279	6900279	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cagggccctggagcctgcgcGgaggtggccttcccgtgcta	16	14	0	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:6900279G>A	ENST00000251535.6	+	2	323	c.270G>A	c.(268-270)gcG>gcA	p.A90A	AC027763.2_ENST00000399541.2_Intron|RP11-589P10.7_ENST00000572547.1_RNA	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	90	PLAT.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						GAGCCTGCGCGGAGGTGGCCT	0.701													5	11					0	0	1	0	0	A	6900279	G	A	6900279	2	1	26	1	0	0	0	0	0	0	0	1	532	1103	39	1		1	ALOX12	17	6900279	Silent	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		6900279	74294931	53	2588										
TP53	7157	broad.mit.edu	37	chr17	7578203	7578203	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cggctcatagggcaccaccaCactatgtcgaaaagtgtttc	9	12	1	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:7578203C>A	ENST00000420246.2	-	6	778	c.646G>T	c.(646-648)Gtg>Ttg	p.V216L	TP53_ENST00000455263.2_Missense_Mutation_p.V216L|TP53_ENST00000359597.4_Missense_Mutation_p.V216L|TP53_ENST00000413465.2_Missense_Mutation_p.V216L|TP53_ENST00000445888.2_Missense_Mutation_p.V216L|TP53_ENST00000269305.4_Missense_Mutation_p.V216L|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	216	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V216M(61)|p.V216del(8)|p.0?(8)|p.V216L(7)|p.?(5)|p.V84M(3)|p.V123M(3)|p.V216fs*6(2)|p.H214fs*5(2)|p.V216fs*32(1)|p.V216fs*33(1)|p.S215fs*27(1)|p.S215fs*29(1)|p.V216fs*5(1)|p.V216_Y220delVVVPY(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.S215fs*31(1)|p.S215_V216insX(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.S215_V218>R(1)|p.S215_V218>M(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACCACCACACTATGTCGA	0.537		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	30					0.00074312	0.000771702	1	1	0	A	7578203	C	A	7578203	3	1	26	1	0	0	0	0	1	0	0	0	16441	478	17	5	648	5	TP53	17	7578203	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	677924	7578203	73617007	54	2589										
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	14	13	3	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:7578394T>C	ENST00000420246.2	-	5	668	c.536A>G	c.(535-537)cAt>cGt	p.H179R	TP53_ENST00000455263.2_Missense_Mutation_p.H179R|TP53_ENST00000359597.4_Missense_Mutation_p.H179R|TP53_ENST00000413465.2_Missense_Mutation_p.H179R|TP53_ENST00000445888.2_Missense_Mutation_p.H179R|TP53_ENST00000269305.4_Missense_Mutation_p.H179R|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	179	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(108)|p.H179L(43)|p.P177_C182delPHHERC(8)|p.0?(8)|p.H47L(4)|p.H86L(4)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.H178_S183delHHERCS(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.H86R(2)|p.H47R(2)|p.R174fs*1(2)|p.H179fs*68(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H46_S51delHHERCS(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H85_S90delHHERCS(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	18					0	0	1	0	0	C	7578394	T	C	7578394	3	2	26	1	0	0	0	0	1	0	0	0	16441	1464	51	4	762	4	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-N8-A4PL-01A-11D-A28R-08	191	7578394	73616816	55	2590										
MYH8	4626	broad.mit.edu	37	chr17	10304252	10304252	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tcatcttcaattttgcttatCaaattgctgatttcaaattc	3	8	5	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:10304252C>T	ENST00000403437.2	-	26	3373	c.3279G>A	c.(3277-3279)ttG>ttA	p.L1093L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1093					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TTTTGCTTATCAAATTGCTGA	0.333									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				5	15					0	0	1	0	0	T	10304252	C	T	10304252	2	4	26	1	0	0	0	0	0	0	0	1	10088	825	29	3		3	MYH8	17	10304252	Silent	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	2725858	10304252	70890958	56	2591										
ABCA9	10350	broad.mit.edu	37	chr17	67008130	67008130	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ttcttactttgtagtcaccaAtgctgctcattgcaatgtat	6	9	3	0	rs144122311		TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:67008130A>G	ENST00000340001.4	-	23	3345	c.3134T>C	c.(3133-3135)aTt>aCt	p.I1045T	ABCA9-AS1_ENST00000458677.1_RNA|ABCA9_ENST00000370732.2_Missense_Mutation_p.I1045T|ABCA9_ENST00000453985.2_Missense_Mutation_p.I1045T	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1045					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GTAGTCACCAATGCTGCTCAT	0.403													21	16					0	0	1	0	0	G	67008130	A	G	67008130	3	3	26	1	0	0	0	0	1	0	0	0	39	101	4	4	1808	4	ABCA9	17	67008130	Missense_Mutation	SNP	A	TCGA-N8-A4PL-01A-11D-A28R-08	56703878	67008130	14187080	57	2592										
SDK2	54549	broad.mit.edu	37	chr17	71346393	71346393	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tacctggtgtacaggccgttCtttcggcagaaagagttctt	11	9	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:71346393C>G	ENST00000392650.3	-	43	6021	c.6021G>C	c.(6019-6021)aaG>aaC	p.K2007N	SDK2_ENST00000388726.3_Missense_Mutation_p.K1988N|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2007					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						ACAGGCCGTTCTTTCGGCAGA	0.612													4	10					0	0	1	0	0	G	71346393	C	G	71346393	3	3	26	1	0	0	0	0	1	0	0	0	14022	912	32	2	509	2	SDK2	17	71346393	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	4338263	71346393	9848817	58	2593										
EXOC7	23265	broad.mit.edu	37	chr17	74079821	74079821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cgggttcttggtgaagggcaCgctgccaaacctgaggaggc	16	10	1	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr17:74079821C>T	ENST00000607838.1	-	20	2126	c.2032G>A	c.(2032-2034)Gtg>Atg	p.V678M	EXOC7_ENST00000411744.2_Missense_Mutation_p.V647M|EXOC7_ENST00000467929.2_Missense_Mutation_p.V627M|EXOC7_ENST00000332065.5_Missense_Mutation_p.V624M|EXOC7_ENST00000405575.4_Missense_Mutation_p.V664M|EXOC7_ENST00000589210.1_Missense_Mutation_p.V655M|EXOC7_ENST00000335146.7_Missense_Mutation_p.V706M	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	706					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			GTGAAGGGCACGCTGCCAAAC	0.612													41	9					0	0	1	0	0	T	74079821	C	T	74079821	3	4	26	1	0	0	0	0	1	0	0	0	5337	536	19	1	95	1	EXOC7	17	74079821	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	2733428	74079821	7115389	59	2594										
KDM4B	23030	broad.mit.edu	37	chr19	5119803	5119805	+	In_Frame_Del	DEL	GAG	GAG	-													0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ctgggccggaggttgaccccGaggaggaggaggaggagccg							TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr19:5119803_5119805delGAG	ENST00000159111.4	+	11	1473_1475	c.1255_1257delGAG	c.(1255-1257)del	p.E424del	KDM4B_ENST00000536461.1_In_Frame_Del_p.E458del	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	424					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GGTTGACCCCGAGGAGGAGGAGG	0.709													2	4	---	---	---	---						-	5119805	GAG	-	5119803	7	5	26	1	0	1	0	1	0	0	0	0	8172	1059	37	0	1289	0	KDM4B	19	5119803	In_Frame_Del	DEL	GAG	TCGA-N8-A4PL-01A-11D-A28R-08		5119803	54009180	60	2595										
CYP4F3	4051	broad.mit.edu	37	chr19	15760898	15760898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	atgccgtcatccaggagcggCgccgcaccctccctagccag	11	18	1	0			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr19:15760898C>T	ENST00000221307.7	+	7	871	c.823C>T	c.(823-825)Cgc>Tgc	p.R275C	CYP4F3_ENST00000585846.1_Missense_Mutation_p.R275C|CYP4F3_ENST00000592424.1_3'UTR|CYP4F3_ENST00000586182.1_Missense_Mutation_p.R275C|CYP4F3_ENST00000591058.1_Missense_Mutation_p.R275C	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	275					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CCAGGAGCGGCGCCGCACCCT	0.572													48	53					0	0	1	0	0	T	15760898	C	T	15760898	3	4	26	1	0	0	0	0	1	0	0	0	4213	768	27	1	845	1	CYP4F3	19	15760898	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	10641095	15760898	43368085	61	2596										
ZNF296	162979	broad.mit.edu	37	chr19	45575175	45575175	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ctgacttgggcatctttttgGgtgatgccttctggctgttt	12	8	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr19:45575175G>C	ENST00000303809.2	-	3	1326	c.1112C>G	c.(1111-1113)cCc>cGc	p.P371R		NM_145288.1	NP_660331.1	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	371					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|lung(3)|prostate(1)|urinary_tract(2)	7						CATCTTTTTGGGTGATGCCTT	0.612													5	217					0	0	1	0	0	C	45575175	G	C	45575175	3	2	26	1	0	0	0	0	1	0	0	0	17884	1232	43	5	319	5	ZNF296	19	45575175	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	29814277	45575175	13553808	62	2597										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715971	52715971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	cctgtgctcagatgacacccCcatggtgcggcgggccgcag	14	15	1	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr19:52715971C>G	ENST00000322088.6	+	5	594	c.536C>G	c.(535-537)cCc>cGc	p.P179R	PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124R	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612			Mis		clear cell ovarian carcinoma								19	34					0	0	1	0	0	G	52715971	C	G	52715971	3	3	26	1	0	0	0	0	1	0	0	0	12430	623	22	5	554	5	PPP2R1A	19	52715971	Missense_Mutation	SNP	C	TCGA-N8-A4PL-01A-11D-A28R-08	7140796	52715971	6413012	63	2598										
PEG3	5178	broad.mit.edu	37	chr19	57326398	57326398	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	tacagaatgtgtgtactcccGactgtcaaccaggcacttcc	8	13	1	1			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chr19:57326398G>A	ENST00000326441.9	-	10	3775	c.3412C>T	c.(3412-3414)Cgg>Tgg	p.R1138W	PEG3_ENST00000593695.1_Missense_Mutation_p.R1012W|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.R1014W|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.R1138W|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1138					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTGTACTCCCGACTGTCAACC	0.483													44	66					0	0	1	0	0	A	57326398	G	A	57326398	3	1	26	1	0	0	0	0	1	0	0	0	11766	1057	37	1	1358	1	PEG3	19	57326398	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08	4610427	57326398	1802585	64	2599										
SMC1A	8243	broad.mit.edu	37	chrX	53432289	53432289	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0461538461538462	3	1	0.559781121751026	1.00294117647059	0.458487394957983	1	1	0	ccccaccagagatcactcctGacttctggaatagggttcca	8	14	2	2			TCGA-N8-A4PL-01A-11D-A28R-08	TCGA-N8-A4PL-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84e0da33-7bb8-457f-a191-143ec728aa63	4ab249eb-a59b-4065-a5f4-ad07b0596c48	g.chrX:53432289G>A	ENST00000322213.4	-	12	2073	c.1946C>T	c.(1945-1947)tCa>tTa	p.S649L	SMC1A_ENST00000375340.6_Missense_Mutation_p.S415L	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	649	Flexible hinge.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						GATCACTCCTGACTTCTGGAA	0.532													3	0					0	0	1	0	0	A	53432289	G	A	53432289	3	1	26	1	0	0	0	0	1	0	0	0	14834	1294	45	3	1811	3	SMC1A	23	53432289	Missense_Mutation	SNP	G	TCGA-N8-A4PL-01A-11D-A28R-08		53432289	101838271	65	2600										
PTCHD2	57540	broad.mit.edu	37	chr1	11589625	11589625	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctccacaggaagctgtacttCgcccagtcccacaagccccc	7	19	0	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:11589625C>T	ENST00000294484.6	+	14	2949	c.2811C>T	c.(2809-2811)ttC>ttT	p.F937F	PTCHD2_ENST00000389575.3_Silent_p.F937F	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	937					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGCTGTACTTCGCCCAGTCCC	0.652													39	106					0	0	1	0	0	T	11589625	C	T	11589625	2	4	27	1	0	0	0	0	0	0	0	1	12781	883	31	1		1	PTCHD2	1	11589625	Silent	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08		11589625	237660996	1	2601										
KIAA2013	90231	broad.mit.edu	37	chr1	11985518	11985518	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gcggccaccaccaccaggtgCaccaacccagtgggcgtagg	13	16	0	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:11985518C>A	ENST00000376572.3	-	1	962	c.777G>T	c.(775-777)gtG>gtT	p.V259V	KIAA2013_ENST00000376576.3_Silent_p.V259V	NM_138346.2	NP_612355.1	Q8IYS2	K2013_HUMAN	KIAA2013	259						integral to membrane				endometrium(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCAGGTGCACCAACCCAG	0.647													20	16					3.51602e-12	3.7141e-12	1	1	0	A	11985518	C	A	11985518	2	1	27	1	0	0	0	0	0	0	0	1	8308	697	25	5		5	KIAA2013	1	11985518	Silent	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	395893	11985518	237265103	2	2602										
INADL	10207	broad.mit.edu	37	chr1	62586895	62586895	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gcagctgtcatccctccttcGctcctgtcatcactggcctg	8	17	3	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:62586895G>A	ENST00000371158.2	+	38	5047	c.4933G>A	c.(4933-4935)Gct>Act	p.A1645T	INADL_ENST00000472512.1_3'UTR	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1645					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TCCCTCCTTCGCTCCTGTCAT	0.507													49	53					0	0	1	0	0	A	62586895	G	A	62586895	3	1	27	1	0	0	0	0	1	0	0	0	7774	1087	38	1	5079	1	INADL	1	62586895	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	50601377	62586895	186663726	3	2603										
SEC22B	9554	broad.mit.edu	37	chr1	145109284	145109292	+	RNA	DEL	AAAAAAAAA	AAAAAAAAA	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gcagagcgagactccgtctcAaaaaaaaagaaaaaaaaaaa					rs77820797		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:145109284_145109292delAAAAAAAAA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										actccgtctcaaaaaaaaagaaaaaaaaa	0.435													3	4	---	---	---	---						-	145109292	AAAAAAAAA	-	145109284	6	5	27	0	1	1	0	1	0	0	0	0	14042	145	5	0		0	SEC22B	1	145109284	RNA	DEL	AAAAAAAAA	TCGA-N8-A4PM-01A-11D-A28R-08	82522389	145109284	104141337	4	2604										
SEC22B	9554	broad.mit.edu	37	chr1	145109975	145109976	+	RNA	INS	-	-	C													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cacatgtgacaggaactttgINSctaaagatctacttgattgg					rs67257307		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													2	4	---	---	---	---						C	145109976	-	C	145109975	6	5	27	0	1	1	1	0	0	0	0	0	14042	1334	46	0		0	SEC22B	1	145109975	RNA	INS	-	TCGA-N8-A4PM-01A-11D-A28R-08	691	145109975	104140646	5	2605										
GJA8	2703	broad.mit.edu	37	chr1	147380635	147380635	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tgcctctgtaccgctgcagcCggtggccctgccccaatgtg	12	16	1	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:147380635C>T	ENST00000240986.4	+	2	606	c.553C>T	c.(553-555)Cgg>Tgg	p.R185W	GJA8_ENST00000369235.1_Missense_Mutation_p.R185W	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	185					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CCGCTGCAGCCGGTGGCCCTG	0.567													6	140					0	0	1	0	0	T	147380635	C	T	147380635	3	4	27	1	0	0	0	0	1	0	0	0	6446	643	23	1	555	1	GJA8	1	147380635	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	2270660	147380635	101869986	6	2606										
TDRD10	126668	broad.mit.edu	37	chr1	154493952	154493952	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	atccagcagcctcgggccccGctggtatgtcttctggcctt	11	15	2	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr1:154493952G>A	ENST00000368482.4	+	6	1204	c.366G>A	c.(364-366)ccG>ccA	p.P122P	TDRD10_ENST00000368480.3_Silent_p.P122P|TDRD10_ENST00000479937.1_3'UTR	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	122							nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCGGGCCCCGCTGGTATGTC	0.527													91	103					0	0	1	0	0	A	154493952	G	A	154493952	2	1	27	1	0	0	0	0	0	0	0	1	15789	1074	38	1		1	TDRD10	1	154493952	Silent	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	7113317	154493952	94756669	7	2607										
IL1RL2	8808	broad.mit.edu	37	chr2	102805588	102805588	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	atactttcagcaagccagccTtttgcttttaattgtacatt	5	9	1	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr2:102805588T>C	ENST00000264257.2	+	3	237	c.111T>C	c.(109-111)ccT>ccC	p.P37P	IL1RL2_ENST00000539491.1_Silent_p.P37P|IL1RL2_ENST00000481806.1_Intron|IL1RL2_ENST00000441515.2_Intron	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	37	Ig-like C2-type 1.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						CAAGCCAGCCTTTTGCTTTTA	0.343													18	24					0	0	1	0	0	C	102805588	T	C	102805588	2	2	27	1	0	0	0	0	0	0	0	1	7707	1596	56	4		4	IL1RL2	2	102805588	Silent	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08		102805588	140393785	8	2608										
CCDC141	285025	broad.mit.edu	37	chr2	179702420	179702420	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cttcaggtcttgtggtagtcGctcttcccctgttccattga	9	12	3	1	rs143765782	byFrequency	TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr2:179702420G>A	ENST00000420890.2	-	23	3643	c.3526C>T	c.(3526-3528)Cga>Tga	p.R1176*	CCDC141_ENST00000480419.1_5'UTR|CCDC141_ENST00000295723.5_Nonsense_Mutation_p.R601*	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	601							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TGTGGTAGTCGCTCTTCCCCT	0.483													36	54					0	0	1	0	0	A	179702420	G	A	179702420	4	1	27	1	0	0	0	0	0	1	0	0	2793	1095	38	1	830	1	CCDC141	2	179702420	Nonsense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	76896832	179702420	63496953	9	2609										
ZDBF2	57683	broad.mit.edu	37	chr2	207175965	207175965	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tgtctttttacgtcatagatAtcagtccaggagcgcttttc	8	9	3	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr2:207175965A>T	ENST00000374423.3	+	5	7099	c.6713A>T	c.(6712-6714)tAt>tTt	p.Y2238F		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2238							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CGTCATAGATATCAGTCCAGG	0.373													12	17					0	0	1	0	0	T	207175965	A	T	207175965	3	4	27	1	0	0	0	0	1	0	0	0	17656	449	16	4	6723	4	ZDBF2	2	207175965	Missense_Mutation	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08	27473545	207175965	36023408	10	2610										
ALCAM	214	broad.mit.edu	37	chr3	105260603	105260603	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ttgcttcaacagctatcacaGttcactgtaagtcacctact	5	12	4	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr3:105260603G>T	ENST00000306107.5	+	8	1485	c.985G>T	c.(985-987)Gtt>Ttt	p.V329F	ALCAM_ENST00000486979.2_Missense_Mutation_p.V278F|ALCAM_ENST00000389927.4_Intron|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000472644.2_Missense_Mutation_p.V329F	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	329					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						AGCTATCACAGTTCACTGTAA	0.393													31	17					8.16721e-17	9.1424e-17	1	1	0	T	105260603	G	T	105260603	3	4	27	1	0	0	0	0	1	0	0	0	484	1029	36	5	1015	5	ALCAM	3	105260603	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		105260603	92761827	11	2611										
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			38	38					0	0	1	0	0	G	178952085	A	G	178952085	3	3	27	1	0	0	0	0	1	0	0	0	11960	217	8	4	3218	4	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08	73691482	178952085	19070345	12	2612										
UBXN7	26043	broad.mit.edu	37	chr3	196094903	196094903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tcctaattatacttactgaaCgggcacattttttgggggga	10	7	0	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr3:196094903C>T	ENST00000296328.4	-	8	904	c.830G>A	c.(829-831)cGt>cAt	p.R277H	UBXN7_ENST00000428095.1_Missense_Mutation_p.R115H|UBXN7_ENST00000535858.1_Missense_Mutation_p.R129H	NM_015562.1	NP_056377.1	O94888	UBXN7_HUMAN	UBX domain protein 7	277							protein binding			NS(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						ACTTACTGAACGGGCACATTT	0.383													34	31					0	0	1	0	0	T	196094903	C	T	196094903	3	4	27	1	0	0	0	0	1	0	0	0	16977	536	19	1	655	1	UBXN7	3	196094903	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	17142818	196094903	1927527	13	2613										
RGS12	6002	broad.mit.edu	37	chr4	3432185	3432185	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	caacagagcagatgaccaacGtgggctgctaaggaaggaag	14	8	0	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr4:3432185G>A	ENST00000336727.3	+	17	4521	c.3617G>A	c.(3616-3618)cGt>cAt	p.R1206H	RGS12_ENST00000306648.7_Missense_Mutation_p.V553M|RGS12_ENST00000338806.4_Missense_Mutation_p.R558H|RGS12_ENST00000382788.3_Missense_Mutation_p.R1206H|RGS12_ENST00000344733.5_Missense_Mutation_p.R1206H|RGS12_ENST00000538395.1_Missense_Mutation_p.V497M	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1206	GoLoco.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GATGACCAACGTGGGCTGCTA	0.493													33	84					0	0	1	0	0	A	3432185	G	A	3432185	3	1	27	1	0	0	0	0	1	0	0	0	13344	1145	40	1	3737	1	RGS12	4	3432185	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		3432185	187722091	14	2614										
FBXW7	0	broad.mit.edu	37	chr4	153244092	153244092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ggtttcttcagtcccattccGactcccaactgcacacacca	5	17	2	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr4:153244092G>A	ENST00000281708.4	-	12	3294	c.2065C>T	c.(2065-2067)Cgg>Tgg	p.R689W	FBXW7_ENST00000263981.5_Missense_Mutation_p.R609W|FBXW7_ENST00000393956.3_Missense_Mutation_p.R513W|FBXW7_ENST00000296555.5_Missense_Mutation_p.R571W|FBXW7_ENST00000603841.1_Missense_Mutation_p.R689W|FBXW7_ENST00000603548.1_Missense_Mutation_p.R689W	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	689					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R689W(10)|p.R450W(3)|p.R609W(3)|p.R571W(1)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GTCCCATTCCGACTCCCAACT	0.478			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								60	69					0	0	1	0	0	A	153244092	G	A	153244092	3	1	27	1	0	0	0	0	1	0	0	0	5801	1057	37	1	62	1	FBXW7	4	153244092	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	149811907	153244092	37910184	15	2615										
ADAMTS16	170690	broad.mit.edu	37	chr5	5200325	5200325	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gtcccctacattggcaggacGcaatggagtcttctcctggt	11	12	2	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr5:5200325G>A	ENST00000274181.7	+	9	1532	c.1394G>A	c.(1393-1395)cGc>cAc	p.R465H	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.R465H	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	465	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TTGGCAGGACGCAATGGAGTC	0.483													31	17					0	0	1	0	0	A	5200325	G	A	5200325	3	1	27	1	0	0	0	0	1	0	0	0	260	1087	38	1	1428	1	ADAMTS16	5	5200325	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		5200325	175714935	16	2616										
ADAMTS12	81792	broad.mit.edu	37	chr5	33658404	33658404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gtgagacaggcccagggtctCgcaggggcgattgaaaccag	16	10	1	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr5:33658404C>T	ENST00000504830.1	-	7	1410	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E359K|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	359	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CCCAGGGTCTCGCAGGGGCGA	0.498										HNSCC(64;0.19)			6	108					0	0	1	0	0	T	33658404	C	T	33658404	3	4	27	1	0	0	0	0	1	0	0	0	256	893	31	1	3781	1	ADAMTS12	5	33658404	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	28458079	33658404	147256856	17	2617										
ERBB2IP	55914	broad.mit.edu	37	chr5	65370850	65370850	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	agatacttcatgtttttcttAgatgcctttgagtaatggac	8	6	2	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr5:65370850A>G	ENST00000284037.5	+	23	4145		c.e23-1		ERBB2IP_ENST00000503913.1_Intron|ERBB2IP_ENST00000380938.2_Splice_Site|ERBB2IP_ENST00000380939.2_Splice_Site|ERBB2IP_ENST00000380935.1_Intron|ERBB2IP_ENST00000511297.1_Splice_Site|ERBB2IP_ENST00000508515.1_Intron|ERBB2IP_ENST00000416865.2_Splice_Site|ERBB2IP_ENST00000506030.1_Splice_Site|ERBB2IP_ENST00000380936.1_Splice_Site|ERBB2IP_ENST00000380943.2_Splice_Site	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein						basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGTTTTTCTTAGATGCCTTTG	0.398													30	18					0	0	1	0	0	G	65370850	A	G	65370850	5	3	27	1	0	0	0	0	0	0	1	0	5235	434	15	4	3710	4	ERBB2IP	5	65370850	Splice_Site	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08	31712446	65370850	115544410	18	2618										
PCDHA6	0	broad.mit.edu	37	chr5	140209120	140209120	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tcacggtgtctgcgcgagacGcggacgcgcaggagaacgcg	17	12	2	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr5:140209120G>A	ENST00000529310.1	+	1	1558	c.1444G>A	c.(1444-1446)Gcg>Acg	p.A482T	PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.A482T|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGAGACGCGGACGCGCA	0.657													67	88					0	0	1	0	0	A	140209120	G	A	140209120	3	1	27	1	0	0	0	0	1	0	0	0	11574	1087	38	1	1446	1	PCDHA6	5	140209120	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	74838270	140209120	40706140	19	2619										
PCDHA7	0	broad.mit.edu	37	chr5	140215891	140215891	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cgagccctagatgagacggaCgcaccgcgccaccgccttct	11	17	1	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr5:140215891C>T	ENST00000525929.1	+	1	1923	c.1923C>T	c.(1921-1923)gaC>gaT	p.D641D	PCDHA7_ENST00000378125.3_Silent_p.D641D|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGACGGACGCACCGCGCC	0.662													30	117					0	0	1	0	0	T	140215891	C	T	140215891	2	4	27	1	0	0	0	0	0	0	0	1	11575	535	19	1		1	PCDHA7	5	140215891	Silent	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	6771	140215891	40699369	20	2620										
HLA-C	3107	broad.mit.edu	37	chr6	31237836	31237836	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gccagcaacgatgcccatgaTggggatggtgggctgggaag	18	8	0	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr6:31237836T>C	ENST00000383329.3	-	5	936	c.922A>G	c.(922-924)Atc>Gtc	p.I308V	HLA-C_ENST00000376228.5_Missense_Mutation_p.I308V			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	308	Connecting peptide.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						ATGCCCATGATGGGGATGGTG	0.612													14	48					0	0	1	0	0	C	31237836	T	C	31237836	3	2	27	1	0	0	0	0	1	0	0	0	7237	1464	51	4	194	4	HLA-C	6	31237836	Missense_Mutation	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08		31237836	139877231	21	2621										
LRRC4	64101	broad.mit.edu	37	chr7	127670673	127670674	+	Frame_Shift_Ins	INS	-	-	A													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	aggtgtggtggtgcacagttINSacctgccacaagagcttcat							TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr7:127670673_127670674insA	ENST00000249363.3	-	2	277_278	c.20_21insT	c.(19-21)gacfs	p.D7fs	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	7						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		GGTGCACAGTTACCTGCCACAA	0.574													23	101	---	---	---	---						A	127670674	-	A	127670673	7	5	27	1	0	1	1	0	0	0	0	0	9041	1741	61	0	1944	0	LRRC4	7	127670673	Frame_Shift_Ins	INS	-	TCGA-N8-A4PM-01A-11D-A28R-08		127670673	31467990	22	2622										
TSPAN33	340348	broad.mit.edu	37	chr7	128806668	128806668	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ggactggtctcagaacatgtAtttcaactgctcagaagaca	9	9	3	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr7:128806668A>T	ENST00000289407.4	+	6	618	c.509A>T	c.(508-510)tAt>tTt	p.Y170F		NM_178562.3	NP_848657.1	Q86UF1	TSN33_HUMAN	tetraspanin 33	170						integral to membrane				NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14						CAGAACATGTATTTCAACTGC	0.527													103	73					0	0	1	0	0	T	128806668	A	T	128806668	3	4	27	1	0	0	0	0	1	0	0	0	16708	449	16	4	531	4	TSPAN33	7	128806668	Missense_Mutation	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08	1135995	128806668	30331995	23	2623										
KEL	3792	broad.mit.edu	37	chr7	142641781	142641781	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ttcatccagggaaggtttctGaggcgagtgatgagggcatc	15	7	2	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr7:142641781G>A	ENST00000355265.2	-	12	1836	c.1362C>T	c.(1360-1362)ctC>ctT	p.L454L		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	454					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GAAGGTTTCTGAGGCGAGTGA	0.602													8	21					0	0	1	0	0	A	142641781	G	A	142641781	2	1	27	1	0	0	0	0	0	0	0	1	8184	1277	45	3		3	KEL	7	142641781	Silent	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	13835113	142641781	16496882	24	2624										
XKR5	389610	broad.mit.edu	37	chr8	6673270	6673270	+	RNA	DEL	A	A	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctaccctttgagcccattgtAaaaaaaaaaaatacgttggg							TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr8:6673270delA	ENST00000518724.1	-	0	1071							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		AGCCCATTGTAAAAAAAAAAA	0.502											OREG0018511	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	3	---	---	---	---						-	6673270	A	-	6673270	6	5	27	0	1	1	0	1	0	0	0	0	17493	377	13	0		0	XKR5	8	6673270	RNA	DEL	A	TCGA-N8-A4PM-01A-11D-A28R-08		6673270	139690752	25	2625										
CCDC107	203260	broad.mit.edu	37	chr9	35660818	35660818	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	atccacgagctgctgcaagaTagcaagccggacaaggatat	11	10	0	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr9:35660818T>C	ENST00000327351.2	+	5	529	c.466T>C	c.(466-468)Tag>Cag	p.*156Q	ARHGEF39_ENST00000378387.3_3'UTR|CCDC107_ENST00000378406.1_3'UTR|CCDC107_ENST00000421582.2_3'UTR|ARHGEF39_ENST00000378395.2_3'UTR|CCDC107_ENST00000378407.3_3'UTR|ARHGEF39_ENST00000343259.3_3'UTR|CCDC107_ENST00000426546.2_Silent_p.D162D|CCDC107_ENST00000378409.3_Silent_p.D162D			Q8WV48	CC107_HUMAN	coiled-coil domain containing 107	0						integral to membrane				endometrium(1)|lung(3)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCTGCAAGATAGCAAGCCGG	0.537													107	149					0	0	1	0	0	C	35660818	T	C	35660818	4	2	27	1	0	0	0	0	0	0	0	0	2760	1403	49	4	504	4	CCDC107	9	35660818	Nonstop_Mutation	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08		35660818	105552613	26	2626										
ZCCHC6	79670	broad.mit.edu	37	chr9	88938512	88938512	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctgagttttcagggtggacaCtgatgtgttcatttcccatt	10	8	2	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr9:88938512C>T	ENST00000277141.6	-	14	2444	c.20G>A	c.(19-21)aGt>aAt	p.S7N	ZCCHC6_ENST00000375963.3_Missense_Mutation_p.S718N|ZCCHC6_ENST00000375961.2_Missense_Mutation_p.S718N|ZCCHC6_ENST00000375960.2_Missense_Mutation_p.S595N			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	718					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						AGGGTGGACACTGATGTGTTC	0.413													22	68					0	0	1	0	0	T	88938512	C	T	88938512	3	4	27	1	0	0	0	0	1	0	0	0	17649	565	20	3	2394	3	ZCCHC6	9	88938512	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	53277694	88938512	52274919	27	2627										
AGAP4	119016	broad.mit.edu	37	chr10	46322004	46322004	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cacacagtgggcgttcccacGcatgttttggatcgactgca	11	12	0	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr10:46322004G>A	ENST00000448048.2	-	7	1476	c.1351C>T	c.(1351-1353)Cgt>Tgt	p.R451C		NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	451	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)|lung(1)|ovary(1)	3						GCGTTCCCACGCATGTTTTGG	0.557													26	149					0	0	1	0	0	A	46322004	G	A	46322004	3	1	27	1	0	0	0	0	1	0	0	0	369	1087	38	1	644	1	AGAP4	10	46322004	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		46322004	89212743	28	2628										
CAMK2G	818	broad.mit.edu	37	chr10	75597241	75597241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cttaccttgacaccgccatcCgacttcttgttcaataggct	6	14	2	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr10:75597241C>T	ENST00000444854.2	-	6	496	c.376G>A	c.(376-378)Gga>Aga	p.G126R	CAMK2G_ENST00000472912.1_5'UTR|CAMK2G_ENST00000322680.3_Silent_p.S325S|CAMK2G_ENST00000423381.1_Silent_p.S346S|CAMK2G_ENST00000394762.2_Silent_p.S325S|CAMK2G_ENST00000372765.1_Silent_p.S346S|CAMK2G_ENST00000351293.3_Silent_p.S325S|CAMK2G_ENST00000322635.3_Silent_p.S346S|CAMK2G_ENST00000305762.7_Silent_p.S325S			Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II gamma	0	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			kidney(2)|large_intestine(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	15	Prostate(51;0.0112)					CACCGCCATCCGACTTCTTGT	0.522													134	102					0	0	1	0	0	T	75597241	C	T	75597241	3	4	27	1	0	0	0	0	1	0	0	0	2620	639	23	1	764	1	CAMK2G	10	75597241	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	29275237	75597241	59937506	29	2629										
TACC2	10579	broad.mit.edu	37	chr10	123844141	123844141	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gagcagggaaggattgggaaGaatggagtctttcctgactt	15	5	1	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr10:123844141G>T	ENST00000369005.1	+	4	2466	c.2126G>T	c.(2125-2127)aGa>aTa	p.R709I	TACC2_ENST00000515603.1_Missense_Mutation_p.R709I|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.R709I|TACC2_ENST00000453444.2_Missense_Mutation_p.R709I|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515273.1_Missense_Mutation_p.R709I	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	709						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGATTGGGAAGAATGGAGTCT	0.527													31	20					3.80469e-20	4.32352e-20	1	1	0	T	123844141	G	T	123844141	3	4	27	1	0	0	0	0	1	0	0	0	15558	942	33	2	2136	2	TACC2	10	123844141	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	48246900	123844141	11690606	30	2630										
CYP2E1	1571	broad.mit.edu	37	chr10	135346210	135346210	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctctagctttacaataatttTcccagctttctacactactt	2	12	2	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr10:135346210T>C	ENST00000463117.2	+	7	935	c.663T>C	c.(661-663)ttT>ttC	p.F221F	CYP2E1_ENST00000252945.3_Silent_p.F221F|SPRN_ENST00000541506.1_Intron			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	221					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	ACAATAATTTTCCCAGCTTTC	0.378									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				5	154					0	0	1	0	0	C	135346210	T	C	135346210	2	2	27	1	0	0	0	0	0	0	0	1	4193	1780	62	4		4	CYP2E1	10	135346210	Silent	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08	11502069	135346210	188537	31	2631										
DEPDC7	91614	broad.mit.edu	37	chr11	33047304	33047304	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	agtgaaaaaacgaaggcaccGtttaaaacgacataatgact	8	7	0	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:33047304G>A	ENST00000311388.3	+	2	522	c.146G>A	c.(145-147)cGt>cAt	p.R49H	DEPDC7_ENST00000241051.3_Missense_Mutation_p.R58H	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	58	DEP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						CGAAGGCACCGTTTAAAACGA	0.393													57	42					0	0	1	0	0	A	33047304	G	A	33047304	3	1	27	1	0	0	0	0	1	0	0	0	4472	1145	40	1	229	1	DEPDC7	11	33047304	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		33047304	101959212	32	2632										
OR4A16	81327	broad.mit.edu	37	chr11	55110833	55110833	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctactattggcagcccctccTtgggctccctaatgtacttc	7	15	0	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:55110833T>C	ENST00000314721.2	+	1	207	c.157T>C	c.(157-159)Ttg>Ctg	p.L53L		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L53V(1)		NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						CAGCCCCTCCTTGGGCTCCCT	0.408													29	103					0	0	1	0	0	C	55110833	T	C	55110833	2	2	27	1	0	0	0	0	0	0	0	1	11088	1606	56	4		4	OR4A16	11	55110833	Silent	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08	22063529	55110833	79895683	33	2633										
AHNAK	79026	broad.mit.edu	37	chr11	62293943	62293943	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ggccctctcctttgaagccaGgcatgctgaactttggcatt	10	12	1	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:62293943G>T	ENST00000378024.4	-	5	8220	c.7946C>A	c.(7945-7947)cCt>cAt	p.P2649H	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2649					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTGAAGCCAGGCATGCTGAA	0.527													49	240					7.88023e-25	9.09257e-25	1	1	0	T	62293943	G	T	62293943	3	4	27	1	0	0	0	0	1	0	0	0	411	1000	35	5	9846	5	AHNAK	11	62293943	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	7183110	62293943	72712573	34	2634										
CCDC88B	283234	broad.mit.edu	37	chr11	64111779	64111779	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tgtggagacacaggagtcccCggagaaggctggccgtagat	16	9	0	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:64111779C>A	ENST00000356786.5	+	14	1810	c.1766C>A	c.(1765-1767)cCg>cAg	p.P589Q	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_5'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	589					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CAGGAGTCCCCGGAGAAGGCT	0.647													47	51					6.4771e-29	7.71083e-29	1	1	0	A	64111779	C	A	64111779	3	1	27	1	0	0	0	0	1	0	0	0	2884	652	23	5	1820	5	CCDC88B	11	64111779	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	1817836	64111779	70894737	35	2635										
CATSPER1	117144	broad.mit.edu	37	chr11	65792758	65792758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gcggattgtgctggaggaccGagtcatgctgtgagccgagc	17	9	1	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:65792758G>A	ENST00000312106.5	-	1	1230	c.1093C>T	c.(1093-1095)Cgg>Tgg	p.R365W		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	365					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CTGGAGGACCGAGTCATGCTG	0.567													34	40					0	0	1	0	0	A	65792758	G	A	65792758	3	1	27	1	0	0	0	0	1	0	0	0	2705	1057	37	1	1297	1	CATSPER1	11	65792758	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	1680979	65792758	69213758	36	2636										
C11orf30	56946	broad.mit.edu	37	chr11	76234280	76234280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	aaagactacaggaaaaggaaCgaccattcaaggcctcccgg	10	11	1	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:76234280C>T	ENST00000529032.1	+	11	1766	c.1766C>T	c.(1765-1767)aCg>aTg	p.T589M	C11orf30_ENST00000334736.3_Missense_Mutation_p.T589M|C11orf30_ENST00000524767.1_Missense_Mutation_p.T604M|C11orf30_ENST00000343878.3_Missense_Mutation_p.T589M|C11orf30_ENST00000525919.1_Missense_Mutation_p.T590M|C11orf30_ENST00000524490.1_Missense_Mutation_p.T505M|C11orf30_ENST00000525038.1_Missense_Mutation_p.T604M|C11orf30_ENST00000533248.1_Missense_Mutation_p.T603M			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	589	Thr-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						GGAAAAGGAACGACCATTCAA	0.438													35	40					0	0	1	0	0	T	76234280	C	T	76234280	3	4	27	1	0	0	0	0	1	0	0	0	1641	536	19	1	1808	1	C11orf30	11	76234280	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	10441522	76234280	58772236	37	2637										
CTSC	1075	broad.mit.edu	37	chr11	88027241	88027241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cacactcatcagttcctctgCggatccggaagtagccattc	8	14	3	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:88027241C>T	ENST00000227266.5	-	7	1439	c.1325G>A	c.(1324-1326)cGc>cAc	p.R442H		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	442					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGTTCCTCTGCGGATCCGGAA	0.498													36	46					0	0	1	0	0	T	88027241	C	T	88027241	3	4	27	1	0	0	0	0	1	0	0	0	4055	768	27	1	70	1	CTSC	11	88027241	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	11792961	88027241	46979275	38	2638										
FAT3	120114	broad.mit.edu	37	chr11	92531160	92531160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctgcaattgtgcgcatttccGtcaccatgtctgacaattct	7	12	3	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr11:92531160G>A	ENST00000298047.6	+	9	4998	c.4981G>A	c.(4981-4983)Gtc>Atc	p.V1661I	FAT3_ENST00000409404.2_Missense_Mutation_p.V1661I|FAT3_ENST00000525166.1_Missense_Mutation_p.V1511I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1661	Cadherin 15.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCGCATTTCCGTCACCATGTC	0.443										TCGA Ovarian(4;0.039)			22	66					0	0	1	0	0	A	92531160	G	A	92531160	3	1	27	1	0	0	0	0	1	0	0	0	5723	1145	40	1	5015	1	FAT3	11	92531160	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	4503919	92531160	42475356	39	2639										
CHD4	1108	broad.mit.edu	37	chr12	6700638	6700638	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tccttctctctcaccattgaAgcggtcaatggcctcttgcc	7	15	4	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr12:6700638A>G	ENST00000309577.6	-	22	3497	c.3334T>C	c.(3334-3336)Ttc>Ctc	p.F1112L	CHD4_ENST00000357008.2_Missense_Mutation_p.F1112L|CHD4_ENST00000544484.1_Missense_Mutation_p.F1109L|CHD4_ENST00000544040.1_Missense_Mutation_p.F1105L			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1112	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCACCATTGAAGCGGTCAATG	0.433													32	33					0	0	1	0	0	G	6700638	A	G	6700638	3	3	27	1	0	0	0	0	1	0	0	0	3349	72	3	4	2480	4	CHD4	12	6700638	Missense_Mutation	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08		6700638	127151257	40	2640										
RARG	5916	broad.mit.edu	37	chr12	53606944	53606944	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gtagggctggctgggccgccGgcgccgggcgtacagcctca	18	14	1	0	rs143739684		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr12:53606944G>A	ENST00000425354.2	-	9	1589	c.1102C>T	c.(1102-1104)Cgg>Tgg	p.R368W	RARG_ENST00000327550.3_Missense_Mutation_p.R296W|RARG_ENST00000338561.5_Missense_Mutation_p.R357W|RARG_ENST00000543726.1_Missense_Mutation_p.R346W|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000394426.1_Missense_Mutation_p.R368W	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	368	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CTGGGCCGCCGGCGCCGGGCG	0.602											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	58					0	0	1	0	0	A	53606944	G	A	53606944	3	1	27	1	0	0	0	0	1	0	0	0	13105	1115	39	1	270	1	RARG	12	53606944	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	46906306	53606944	80244951	41	2641										
MYF5	4617	broad.mit.edu	37	chr12	81111292	81111292	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	aactactatagcctgccgggAcagagctgctcggagcccac	11	14	0	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr12:81111292A>T	ENST00000228644.3	+	1	602	c.450A>T	c.(448-450)ggA>ggT	p.G150G		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	150					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						GCCTGCCGGGACAGAGCTGCT	0.557													93	137					0	0	1	0	0	T	81111292	A	T	81111292	2	4	27	1	0	0	0	0	0	0	0	1	10074	262	10	4		4	MYF5	12	81111292	Silent	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08	27504348	81111292	52740603	42	2642										
DCLK1	9201	broad.mit.edu	37	chr13	36686233	36686233	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gcttcctttggcagtggccaGtgaagacactgcccgagaag	13	11	0	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr13:36686233G>A	ENST00000255448.4	-	3	707	c.496C>T	c.(496-498)Ctg>Ttg	p.L166L	DCLK1_ENST00000379892.4_Silent_p.L166L|DCLK1_ENST00000360631.3_Silent_p.L166L	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	166					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCAGTGGCCAGTGAAGACACT	0.537													58	58					0	0	1	0	0	A	36686233	G	A	36686233	2	1	27	1	0	0	0	0	0	0	0	1	4314	1020	36	3		3	DCLK1	13	36686233	Silent	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		36686233	78483645	43	2643										
OXGR1	27199	broad.mit.edu	37	chr13	97639792	97639792	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	agcagatctgtgcaggccagGttcagcataatgatggtgct	13	8	2	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr13:97639792G>A	ENST00000298440.1	-	4	465	c.222C>T	c.(220-222)aaC>aaT	p.N74N	OXGR1_ENST00000543457.1_Silent_p.N74N	NM_080818.3	NP_543008.3	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	74						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			NS(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TGCAGGCCAGGTTCAGCATAA	0.458													34	40					0	0	1	0	0	A	97639792	G	A	97639792	2	1	27	1	0	0	0	0	0	0	0	1	11378	1252	44	3		3	OXGR1	13	97639792	Silent	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	60953559	97639792	17530086	44	2644										
TMTC4	84899	broad.mit.edu	37	chr13	101315367	101315367	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	catgaggacagagatgccacTgtgcaggaggatgttgacca	14	8	0	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr13:101315367T>C	ENST00000342624.5	-	5	661	c.403A>G	c.(403-405)Agt>Ggt	p.S135G	TMTC4_ENST00000376234.3_Missense_Mutation_p.S116G|TMTC4_ENST00000328767.5_Intron	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	116						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GAGATGCCACTGTGCAGGAGG	0.597													49	138					0	0	1	0	0	C	101315367	T	C	101315367	3	2	27	1	0	0	0	0	1	0	0	0	16322	1580	55	4	1939	4	TMTC4	13	101315367	Missense_Mutation	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08	3675575	101315367	13854511	45	2645										
F10	2159	broad.mit.edu	37	chr13	113777240	113777240	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cctgctgctcggggaaagtcGtaagtgcccctcgcccttca	11	15	1	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr13:113777240G>A	ENST00000375559.3	+	1	108		c.e1+1		F10_ENST00000483537.1_Splice_Site|F10_ENST00000409306.1_Splice_Site|F10_ENST00000375551.3_Splice_Site	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X						blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGAAAGTCGTAAGTGCCCC	0.662													35	19					0	0	1	0	0	A	113777240	G	A	113777240	5	1	27	1	0	0	0	0	0	0	1	0	5364	1159	40	1	73	1	F10	13	113777240	Splice_Site	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	12461873	113777240	1392638	46	2646										
MYH7	4625	broad.mit.edu	37	chr14	23885021	23885021	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tcgttggcacggactgcatcGtccagctgaatctgggtgtc	13	11	1	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr14:23885021G>A	ENST00000355349.3	-	35	5136	c.4974C>T	c.(4972-4974)gaC>gaT	p.D1658D		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1658					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGACTGCATCGTCCAGCTGAA	0.612													28	32					0	0	1	0	0	A	23885021	G	A	23885021	2	1	27	1	0	0	0	0	0	0	0	1	10086	1136	40	1		1	MYH7	14	23885021	Silent	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		23885021	83464519	47	2647										
ZFP36L1	677	broad.mit.edu	37	chr14	69257046	69257073	+	Frame_Shift_Del	DEL	TCACCCTTGAGGCTGCTGAGGAGCTGGT	TCACCCTTGAGGCTGCTGAGGAGCTGGT	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	agctcagagcgggggctggcTcacccttgaggctgctgagg							TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr14:69257046_69257073delTCACCCTTGAGGCTGCTGAGGAGCTGGT	ENST00000439696.2	-	2	495_522	c.194_221delACCAGCTCCTCAGCAGCCTCAAGGGTGA	c.(193-222)agfs	p.NQLLSSLKGE65fs	ZFP36L1_ENST00000555997.1_3'UTR|ZFP36L1_ENST00000336440.3_Frame_Shift_Del_p.NQLLSSLKGE65fs	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	65					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GGGGGCTGGCTCACCCTTGAGGCTGCTGAGGAGCTGGTTCTGGTGGAA	0.689											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	43	---	---	---	---						-	69257073	TCACCCTTGAGGCTGCTGAGGAGCTGGT	-	69257046	7	5	27	1	0	1	0	1	0	0	0	0	17703	1551	54	0	799	0	ZFP36L1	14	69257046	Frame_Shift_Del	DEL	TCACCCTTGAGGCTGCTGAGGAGCTGGT	TCGA-N8-A4PM-01A-11D-A28R-08	45372025	69257046	38092494	48	2648										
TTC7B	145567	broad.mit.edu	37	chr14	91142978	91142978	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tcactcttgtgttcaggtatCctgctcagcacagcgtcccg	9	14	4	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr14:91142978C>A	ENST00000357056.2	-	9	1162	c.1041G>T	c.(1039-1041)agG>agT	p.R347S	TTC7B_ENST00000328459.6_Missense_Mutation_p.R347S			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	347							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				GTTCAGGTATCCTGCTCAGCA	0.527													58	70					7.50695e-29	8.79721e-29	1	1	0	A	91142978	C	A	91142978	3	1	27	1	0	0	0	0	1	0	0	0	16774	854	30	2	1538	2	TTC7B	14	91142978	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	21885932	91142978	16206562	49	2649										
NIPA2	81614	broad.mit.edu	37	chr15	23006811	23006811	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	aggacccaccacgaagattaAtatcaaggccacaatgacca	7	12	1	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr15:23006811A>G	ENST00000337451.3	-	8	1105	c.493T>C	c.(493-495)Tta>Cta	p.L165L	NIPA2_ENST00000359727.4_Silent_p.L146L|NIPA2_ENST00000398014.2_Silent_p.L165L|NIPA2_ENST00000398013.3_Silent_p.L165L|NIPA2_ENST00000539711.2_Silent_p.L146L	NM_030922.6	NP_112184.4	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 2	165						early endosome|integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(4)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		ACGAAGATTAATATCAAGGCC	0.448													13	43					0	0	1	0	0	G	23006811	A	G	23006811	2	3	27	1	0	0	0	0	0	0	0	1	10469	98	4	4		4	NIPA2	15	23006811	Silent	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08		23006811	79524581	50	2650										
NDN	4692	broad.mit.edu	37	chr15	23931940	23931940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gggcgaggatgaggctggtgCgccggaggatgctcctgcac	19	10	0	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr15:23931940C>T	ENST00000331837.4	-	1	510	c.425G>A	c.(424-426)cGc>cAc	p.R142H		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	142	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding	p.R142H(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GAGGCTGGTGCGCCGGAGGAT	0.587									Prader-Willi syndrome				21	16					0	0	1	0	0	T	23931940	C	T	23931940	3	4	27	1	0	0	0	0	1	0	0	0	10293	768	27	1	544	1	NDN	15	23931940	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	925129	23931940	78599452	51	2651										
HERC1	8925	broad.mit.edu	37	chr15	64021494	64021494	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctttgagcaaatttgcagaaCgtgaataaatatctgtggca	9	6	1	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr15:64021494C>T	ENST00000443617.2	-	16	3182	c.3095G>A	c.(3094-3096)cGt>cAt	p.R1032H		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1032					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ATTTGCAGAACGTGAATAAAT	0.343													5	19					0	0	1	0	0	T	64021494	C	T	64021494	3	4	27	1	0	0	0	0	1	0	0	0	7097	536	19	1	11742	1	HERC1	15	64021494	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	40089554	64021494	38509898	52	2652										
SH3GL3	6457	broad.mit.edu	37	chr15	84257518	84257518	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	caccacctctgtagtgaagaCgacaggtaagttgaccattc	9	11	1	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr15:84257518C>A	ENST00000324537.5	+	11	1349	c.857C>A	c.(856-858)aCg>aAg	p.T286K	SH3GL3_ENST00000535412.1_Missense_Mutation_p.T278K|SH3GL3_ENST00000434347.1_Missense_Mutation_p.T286K|SH3GL3_ENST00000427482.2_Missense_Mutation_p.T278K			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	278	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						GTAGTGAAGACGACAGGTAAG	0.443													20	13					2.94398e-08	3.02464e-08	1	1	0	A	84257518	C	A	84257518	3	1	27	1	0	0	0	0	1	0	0	0	14306	536	19	5	863	5	SH3GL3	15	84257518	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	20236024	84257518	18273874	53	2653										
RLTPR	146206	broad.mit.edu	37	chr16	67680200	67680200	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ccatcaagaaggtcttccctCgctcgacccttgggtgaggc	11	14	2	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr16:67680200C>T	ENST00000334583.6	+	5	689	c.361C>T	c.(361-363)Cgc>Tgc	p.R121C	RLTPR_ENST00000545661.1_Missense_Mutation_p.R121C	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	121										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGTCTTCCCTCGCTCGACCCT	0.637													14	27					0	0	1	0	0	T	67680200	C	T	67680200	3	4	27	1	0	0	0	0	1	0	0	0	13445	884	31	1	379	1	RLTPR	16	67680200	Missense_Mutation	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08		67680200	22674553	54	2654										
ABR	29	broad.mit.edu	37	chr17	915093	915093	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ctcccagactcactggcatcGaagacggccttgagcgcctg	11	15	1	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr17:915093G>T	ENST00000544583.2	-	19	2555	c.1956C>A	c.(1954-1956)ttC>ttA	p.F652L	ABR_ENST00000291107.2_Missense_Mutation_p.F661L|ABR_ENST00000302538.5_Missense_Mutation_p.F698L|ABR_ENST00000572441.1_Intron|ABR_ENST00000543210.2_Missense_Mutation_p.F149L|ABR_ENST00000536794.2_Missense_Mutation_p.F480L|ABR_ENST00000574437.1_Missense_Mutation_p.F652L	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	698	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CACTGGCATCGAAGACGGCCT	0.647													15	22					3.35478e-16	3.70012e-16	1	1	0	T	915093	G	T	915093	3	4	27	1	0	0	0	0	1	0	0	0	99	1049	37	2	505	2	ABR	17	915093	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		915093	80280117	55	2655										
TP53	7157	broad.mit.edu	37	chr17	7579324	7579325	+	Frame_Shift_Del	DEL	AG	AG	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	caactgaccgtgcaagtcacAgacttggctgtcccagaatg							TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr17:7579324_7579325delAG	ENST00000420246.2	-	4	494_495	c.362_363delCT	c.(361-363)tfs	p.S121fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.S121fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.S121fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.S121fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.S121fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.S121fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	121	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		S -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G59fs*23(3)|p.S121fs*27(1)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.V122fs*46(1)|p.H115fs*27(1)|p.Y107fs*44(1)|p.S121fs*2(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.S121F(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCAAGTCACAGACTTGGCTGT	0.559		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			69	9	---	---	---	---						-	7579325	AG	-	7579324	7	5	27	1	0	1	0	1	0	0	0	0	16441	175	7	0	939	0	TP53	17	7579324	Frame_Shift_Del	DEL	AG	TCGA-N8-A4PM-01A-11D-A28R-08	6664231	7579324	73615886	56	2656										
FZD2	2535	broad.mit.edu	37	chr17	42636256	42636256	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gacggcgacctgctgagcggCgtgtgcttcgtaggcctcaa	15	12	1	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr17:42636256C>G	ENST00000315323.3	+	1	1332	c.1200C>G	c.(1198-1200)ggC>ggG	p.G400G		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	400					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGCTGAGCGGCGTGTGCTTCG	0.662													84	8					0	0	1	0	0	G	42636256	C	G	42636256	2	3	27	1	0	0	0	0	0	0	0	1	6164	755	27	5		5	FZD2	17	42636256	Silent	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08	35056932	42636256	38558954	57	2657										
COLEC12	81035	broad.mit.edu	37	chr18	321700	321700	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cgcaaatgaagttattgacgTcttcacattggaaatcgttc	8	8	2	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr18:321700T>C	ENST00000400256.3	-	9	2378	c.2171A>G	c.(2170-2172)gAc>gGc	p.D724G		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	724	C-type lectin.				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GTTATTGACGTCTTCACATTG	0.502													6	295					0	0	1	0	0	C	321700	T	C	321700	3	2	27	1	0	0	0	0	1	0	0	0	3735	1667	58	4	65	4	COLEC12	18	321700	Missense_Mutation	SNP	T	TCGA-N8-A4PM-01A-11D-A28R-08		321700	77755548	58	2658										
LAMA1	284217	broad.mit.edu	37	chr18	6965302	6965302	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cctaccttgcttccggtttcGctggaaggcaattttgtacc	9	12	0	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr18:6965302G>A	ENST00000389658.3	-	50	7273	c.7180C>T	c.(7180-7182)Cga>Tga	p.R2394*		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2394	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCCGGTTTCGCTGGAAGGCA	0.443													50	42					0	0	1	0	0	A	6965302	G	A	6965302	4	1	27	1	0	0	0	0	0	1	0	0	8643	1095	38	1	2103	1	LAMA1	18	6965302	Nonsense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	6643602	6965302	71111946	59	2659										
ANKRD12	23253	broad.mit.edu	37	chr18	9281098	9281098	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	ttccccttgttgatgttaacGacgactttgaattgactcct	7	10	0	3			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr18:9281098G>T	ENST00000383440.2	+	12	6351	c.6094G>T	c.(6094-6096)Gac>Tac	p.D2032Y	ANKRD12_ENST00000400020.3_Missense_Mutation_p.D2032Y|ANKRD12_ENST00000262126.3_Missense_Mutation_p.D2055Y	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	2055						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						TGATGTTAACGACGACTTTGA	0.408													44	64					3.76604e-16	4.09352e-16	1	1	0	T	9281098	G	T	9281098	3	4	27	1	0	0	0	0	1	0	0	0	636	1058	37	2	6209	2	ANKRD12	18	9281098	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	2315796	9281098	68796150	60	2660										
CLEC17A	388512	broad.mit.edu	37	chr19	14707736	14707736	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gtctggaggtcctggctgctGccagaagaggtggatggtgt	18	7	1	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr19:14707736G>T	ENST00000547437.1	+	9	571	c.494G>T	c.(493-495)tGc>tTc	p.C165F	CLEC17A_ENST00000397439.2_Missense_Mutation_p.C148F|CLEC17A_ENST00000417570.1_Missense_Mutation_p.C165F	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	165						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										CCTGGCTGCTGCCAGAAGAGG	0.572													7	6					0.00198382	0.00198382	1	1	0	T	14707736	G	T	14707736	3	4	27	1	0	0	0	0	1	0	0	0	3524	1319	46	5	473	5	CLEC17A	19	14707736	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		14707736	44421247	61	2661										
TGFB1	7040	broad.mit.edu	37	chr19	41848131	41848131	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cacaggagcagtgggcgctaAggcgaaagccctcaatttcc	12	12	1	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr19:41848131A>C	ENST00000221930.5	-	4	1522	c.656T>G	c.(655-657)cTt>cGt	p.L219R		NM_000660.4	NP_000651.3	P01137	TGFB1_HUMAN	transforming growth factor, beta 1	219					active induction of host immune response by virus|ATP biosynthetic process|cell cycle arrest|cell growth|cell-cell junction organization|chondrocyte differentiation|connective tissue replacement involved in inflammatory response wound healing|epidermal growth factor receptor signaling pathway|evasion of host defenses by virus|hemopoietic progenitor cell differentiation|induction of apoptosis|lymph node development|mitotic cell cycle G1/S transition checkpoint|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of cell-cell adhesion|negative regulation of DNA replication|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|negative regulation of macrophage cytokine production|negative regulation of mitotic cell cycle|negative regulation of protein phosphorylation|ossification involved in bone remodeling|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of collagen biosynthetic process|positive regulation of epithelial to mesenchymal transition|positive regulation of fibroblast migration|positive regulation of interleukin-17 production|positive regulation of isotype switching to IgA isotypes|positive regulation of MAP kinase activity|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein dephosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|protein export from nucleus|protein import into nucleus, translocation|receptor catabolic process|regulation of DNA binding|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|response to estradiol stimulus|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway|viral infectious cycle	extracellular space|Golgi lumen|nucleus|platelet alpha granule lumen|proteinaceous extracellular matrix	growth factor activity|type II transforming growth factor beta receptor binding			endometrium(1)|large_intestine(2)|lung(4)|skin(1)	8					Hyaluronidase(DB00070)	GTGGGCGCTAAGGCGAAAGCC	0.592													20	14					0	0	1	0	0	C	41848131	A	C	41848131	3	2	27	1	0	0	0	0	1	0	0	0	15875	72	3	4	532	4	TGFB1	19	41848131	Missense_Mutation	SNP	A	TCGA-N8-A4PM-01A-11D-A28R-08	27140395	41848131	17280852	62	2662										
ARHGAP35	2909	broad.mit.edu	37	chr19	47423882	47423882	+	Frame_Shift_Del	DEL	T	T	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gtcaggcttcctgtgaactcTttccagacgccaacatttca							TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr19:47423882delT	ENST00000404338.3	+	1	1950	c.1950delT	c.(1948-1950)tcfs	p.S650fs		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	650					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTGTGAACTCTTTCCAGACGC	0.438													49	59	---	---	---	---						-	47423882	T	-	47423882	7	5	27	1	0	1	0	1	0	0	0	0	6835	1596	56	0	1952	0	ARHGAP35	19	47423882	Frame_Shift_Del	DEL	T	TCGA-N8-A4PM-01A-11D-A28R-08	5575751	47423882	11705101	63	2663										
KDELR1	10945	broad.mit.edu	37	chr19	48894581	48894582	+	Frame_Shift_Ins	INS	-	-	G													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	caagatgatggcgaggaggtINSgggagaggtctcccaggaat							TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr19:48894581_48894582insG	ENST00000330720.2	-	1	228_229	c.34_35insC	c.(34-36)cctfs	p.P12fs		NM_006801.2	NP_006792.1	P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	12					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|pancreas(1)|urinary_tract(1)	11		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		GGCGAGGAGGTGGGAGAGGTCT	0.663											OREG0025606	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	3	---	---	---	---						G	48894582	-	G	48894581	7	5	27	1	0	1	1	0	0	0	0	0	8162	1696	59	0	623	0	KDELR1	19	48894581	Frame_Shift_Ins	INS	-	TCGA-N8-A4PM-01A-11D-A28R-08	1470699	48894581	10234402	64	2664										
NLRP8	126205	broad.mit.edu	37	chr19	56466006	56466006	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tacttaccatgtctgcttctGcccaaaagaccccagggtag	8	13	2	1			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr19:56466006G>A	ENST00000291971.3	+	3	653	c.582G>A	c.(580-582)ctG>ctA	p.L194L	NLRP8_ENST00000590542.1_Silent_p.L194L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	194						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTCTGCTTCTGCCCAAAAGAC	0.522													56	46					0	0	1	0	0	A	56466006	G	A	56466006	2	1	27	1	0	0	0	0	0	0	0	1	10529	1306	46	3		3	NLRP8	19	56466006	Silent	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08	7571425	56466006	2662977	65	2665										
TPX2	22974	broad.mit.edu	37	chr20	30354424	30354424	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	aacaatccattccgtcaaatGcttgttcttccctggaagtt	6	11	2	0			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr20:30354424G>T	ENST00000340513.4	+	5	823	c.295G>T	c.(295-297)Gct>Tct	p.A99S	TPX2_ENST00000300403.6_Missense_Mutation_p.A99S			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	99					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			TCCGTCAAATGCTTGTTCTTC	0.428													41	112					1.47197e-15	1.57711e-15	1	1	0	T	30354424	G	T	30354424	3	4	27	1	0	0	0	0	1	0	0	0	16492	1319	46	5	305	5	TPX2	20	30354424	Missense_Mutation	SNP	G	TCGA-N8-A4PM-01A-11D-A28R-08		30354424	32671096	66	2666										
BAGE2	85319	broad.mit.edu	37	chr21	11056763	11056763	+	RNA	DEL	T	T	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	gtagcactgccattgagtaaTaaaatgttccaatattagag					rs2838178		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr21:11056763delT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATTGAGTAATAAAATGTTCC	0.299													4	3	---	---	---	---						-	11056763	T	-	11056763	6	5	27	0	1	1	0	1	0	0	0	0	1290	1421	49	0		0	BAGE2	21	11056763	RNA	DEL	T	TCGA-N8-A4PM-01A-11D-A28R-08		11056763	37073132	67	2667										
BAGE2	85319	broad.mit.edu	37	chr21	11057307	11057308	+	RNA	INS	-	-	A													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	acagacctggagaagataggINSaaaaaaagcttttatcaaca					rs76234576		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr21:11057307_11057308insA	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAGAAGATAGGAAAAAAAGCTT	0.342													4	3	---	---	---	---						A	11057308	-	A	11057307	6	5	27	0	1	1	1	0	0	0	0	0	1290	1189	41	0		0	BAGE2	21	11057307	RNA	INS	-	TCGA-N8-A4PM-01A-11D-A28R-08	544	11057307	37072588	68	2668										
BAGE2	85319	broad.mit.edu	37	chr21	11087765	11087765	+	RNA	DEL	A	A	-													0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	cataaagtcagtaagactgtAttttttatggactcatcaca					rs150587031		TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chr21:11087765delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAAGACTGTATTTTTTATGG	0.373													4	6	---	---	---	---						-	11087765	A	-	11087765	6	5	27	0	1	1	0	1	0	0	0	0	1290	464	16	0		0	BAGE2	21	11087765	RNA	DEL	A	TCGA-N8-A4PM-01A-11D-A28R-08	30458	11087765	37042130	69	2669										
ARR3	407	broad.mit.edu	37	chrX	69489951	69489951	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0142857142857143	1	1	0.253763440860215	0	0.261693548387097	1	1	0	tctgtccttctctccacagaCggtgttgtcctggttgatcc	9	13	2	2			TCGA-N8-A4PM-01A-11D-A28R-08	TCGA-N8-A4PM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f45fce6a-f718-486c-8e24-57f062f20b37	1e5842cc-eef6-4cf3-b869-b7dacdba7d92	g.chrX:69489951C>T	ENST00000374495.3	+	5	200	c.100_splice	c.e5-1	p.D34_splice	ARR3_ENST00000307959.8_Splice_Site_p.D34_splice			P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	34					signal transduction|visual perception	cytoplasm|soluble fraction				endometrium(3)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	16						TCTCCACAGACGGTGTTGTCC	0.433													24	4					0	0	1	0	0	T	69489951	C	T	69489951	5	4	27	1	0	0	0	0	0	0	1	0	978	550	19	1	116	1	ARR3	23	69489951	Splice_Site	SNP	C	TCGA-N8-A4PM-01A-11D-A28R-08		69489951	85780609	70	2670										
HMGCL	3155	broad.mit.edu	37	chr1	24147025	24147025	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cattttgtagtccatctcggGgaccaacttccacaattttc	6	12	1	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:24147025G>C	ENST00000374483.4	-	3	715	c.44C>G	c.(43-45)cCc>cGc	p.P15R	HMGCL_ENST00000374490.3_Missense_Mutation_p.P40R|HMGCL_ENST00000509389.1_5'UTR|HMGCL_ENST00000436439.2_Missense_Mutation_p.P40R			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	40					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		TCCATCTCGGGGACCAACTTC	0.393													18	46					0	0	1	0	0	C	24147025	G	C	24147025	3	2	28	1	0	0	0	0	1	0	0	0	7269	1232	43	5	890	5	HMGCL	1	24147025	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		24147025	225103596	1	2671										
RHD	6007	broad.mit.edu	37	chr1	25627530	25627530	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgccaaagcctctacccgagGgaacggaggataaagatcag	12	10	2	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:25627530G>A	ENST00000328664.4	+	4	735	c.580G>A	c.(580-582)Gga>Aga	p.G194R	RHD_ENST00000342055.5_Missense_Mutation_p.G194R|RHD_ENST00000423253.1_3'UTR|RHD_ENST00000417538.2_Missense_Mutation_p.G194R|RHD_ENST00000568195.1_Missense_Mutation_p.G194R|RHD_ENST00000454452.2_Missense_Mutation_p.G194R|RHD_ENST00000423810.2_Missense_Mutation_p.G194R|RHD_ENST00000357542.4_Missense_Mutation_p.G194R	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	194						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCTACCCGAGGGAACGGAGGA	0.532													48	46					0	0	1	0	0	A	25627530	G	A	25627530	3	1	28	1	0	0	0	0	1	0	0	0	13376	1233	43	3	594	3	RHD	1	25627530	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	1480505	25627530	223623091	2	2672										
FNDC5	252995	broad.mit.edu	37	chr1	33333378	33333378	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ccacatgaacaggaccacgaCgatgatcagcacctcgcctg	9	15	1	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:33333378C>T	ENST00000373471.3	-	4	541	c.250G>A	c.(250-252)Gtc>Atc	p.V84I		NM_001171940.1|NM_153756.2	NP_001165411.1|NP_715637.1	Q8NAU1	FNDC5_HUMAN	fibronectin type III domain containing 5	143	Fibronectin type-III.					integral to membrane|peroxisomal membrane				breast(1)|large_intestine(1)|lung(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AGGACCACGACGATGATCAGC	0.552													37	23					0	0	1	0	0	T	33333378	C	T	33333378	3	4	28	1	0	0	0	0	1	0	0	0	6004	536	19	1	248	1	FNDC5	1	33333378	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	7705848	33333378	215917243	3	2673										
MRPL37	51253	broad.mit.edu	37	chr1	54681910	54681910	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgtttcaactgaataccacaGacctggactgtaacgagggt	10	9	1	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:54681910G>A	ENST00000605337.1	+	6	1135	c.1087G>A	c.(1087-1089)Gac>Aac	p.D363N	MRPL37_ENST00000336230.6_Missense_Mutation_p.D232N|MRPL37_ENST00000360840.5_Missense_Mutation_p.D363N			Q9BZE1	RM37_HUMAN	mitochondrial ribosomal protein L37	363					translation	mitochondrial ribosome	structural constituent of ribosome			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(4)|skin(2)	19						GAATACCACAGACCTGGACTG	0.512													30	49					0	0	1	0	0	A	54681910	G	A	54681910	3	1	28	1	0	0	0	0	1	0	0	0	9848	942	33	3	1109	3	MRPL37	1	54681910	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	21348532	54681910	194568711	4	2674										
SPTA1	6708	broad.mit.edu	37	chr1	158621165	158621165	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	agccttagttacctgccggaTttgagctccttctggtgtta	10	10	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:158621165T>A	ENST00000368148.3	-	24	3649	c.3469A>T	c.(3469-3471)Atc>Ttc	p.I1157F	SPTA1_ENST00000368147.3_Missense_Mutation_p.I1157F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1157					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ACCTGCCGGATTTGAGCTCCT	0.453													87	134					0	0	1	0	0	A	158621165	T	A	158621165	3	1	28	1	0	0	0	0	1	0	0	0	15171	1493	52	4	3906	4	SPTA1	1	158621165	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08	103939255	158621165	90629456	5	2675										
DNM3	26052	broad.mit.edu	37	chr1	171958171	171958172	+	Frame_Shift_Ins	INS	-	-	A													0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tatcgagtatcagatcagagINSaaatgattatgcagttcatc							TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:171958171_171958172insA	ENST00000358155.4	+	4	648_649	c.472_473insA	c.(472-474)aatfs	p.N158fs	DNM3_ENST00000367733.2_Frame_Shift_Ins_p.N158fs|DNM3_ENST00000367731.1_Frame_Shift_Ins_p.N158fs|DNM3_ENST00000520906.1_Frame_Shift_Ins_p.N158fs|DNM3_ENST00000355305.5_Frame_Shift_Ins_p.N158fs	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	158					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TCAGATCAGAGAAATGATTATG	0.426													22	19	---	---	---	---						A	171958172	-	A	171958171	7	5	28	1	0	1	1	0	0	0	0	0	4700	943	33	0	486	0	DNM3	1	171958171	Frame_Shift_Ins	INS	-	TCGA-N8-A4PN-01A-11D-A28R-08	13337006	171958171	77292450	6	2676										
USH2A	7399	broad.mit.edu	37	chr1	216390848	216390848	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ggcctgtgaccaagtgacagGtttcattcaaggctcctgag	12	10	2	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:216390848G>A	ENST00000366943.2	-	15	3424	c.3038C>T	c.(3037-3039)aCc>aTc	p.T1013I	USH2A_ENST00000307340.3_Missense_Mutation_p.T1013I|USH2A_ENST00000366942.3_Missense_Mutation_p.T1013I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1013	Laminin EGF-like 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAGTGACAGGTTTCATTCAA	0.398										HNSCC(13;0.011)			26	26					0	0	1	0	0	A	216390848	G	A	216390848	3	1	28	1	0	0	0	0	1	0	0	0	17095	1261	44	3	12816	3	USH2A	1	216390848	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	44432677	216390848	32859773	7	2677										
RYR2	6262	broad.mit.edu	37	chr1	237886488	237886488	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	aagacttaccaaacaggactGatgatacctcagatccagag	8	10	1	5			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr1:237886488G>T	ENST00000366574.2	+	74	10932	c.10615G>T	c.(10615-10617)Gat>Tat	p.D3539Y	RYR2_ENST00000360064.6_Missense_Mutation_p.D3537Y|RYR2_ENST00000542537.1_Missense_Mutation_p.D3523Y	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3539					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAACAGGACTGATGATACCTC	0.398													31	98					7.35883e-32	8.00814e-32	1	1	0	T	237886488	G	T	237886488	3	4	28	1	0	0	0	0	1	0	0	0	13820	1290	45	2	10909	2	RYR2	1	237886488	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	21495640	237886488	11364133	8	2678										
DCTN1	1639	broad.mit.edu	37	chr2	74604816	74604816	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cagaagaatcaggtgtctctGgggaagtagtatctgctcca	12	8	3	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr2:74604816G>A	ENST00000361874.3	-	3	634	c.317C>T	c.(316-318)cCa>cTa	p.P106L	DCTN1_ENST00000409567.3_Missense_Mutation_p.P106L|DCTN1_ENST00000409240.1_Missense_Mutation_p.P89L|DCTN1_ENST00000394003.3_Missense_Mutation_p.P106L|DCTN1_ENST00000409868.1_Missense_Mutation_p.P89L	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	106					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						AGGTGTCTCTGGGGAAGTAGT	0.463													21	100					0	0	1	0	0	A	74604816	G	A	74604816	3	1	28	1	0	0	0	0	1	0	0	0	4329	1348	47	3	3651	3	DCTN1	2	74604816	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		74604816	168594557	9	2679										
COL3A1	1281	broad.mit.edu	37	chr2	189854844	189854844	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	agaatcaggtagacccggacGacctggagagcgaggattgc	15	9	1	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr2:189854844G>A	ENST00000304636.3	+	9	883	c.713G>A	c.(712-714)cGa>cAa	p.R238Q	COL3A1_ENST00000317840.5_Missense_Mutation_p.R238Q	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGACCCGGACGACCTGGAGAG	0.388													13	29					0	0	1	0	0	A	189854844	G	A	189854844	3	1	28	1	0	0	0	0	1	0	0	0	3711	1058	37	1	747	1	COL3A1	2	189854844	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	115250028	189854844	53344529	10	2680										
MAP2	4133	broad.mit.edu	37	chr2	210557510	210557510	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ctcagccagagacaactaaaActtaccctgataaaaaggac	6	11	1	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr2:210557510A>C	ENST00000360351.4	+	7	1122	c.616A>C	c.(616-618)Act>Cct	p.T206P	MAP2_ENST00000447185.1_Missense_Mutation_p.T202P|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	206					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GACAACTAAAACTTACCCTGA	0.458													20	39					0	0	1	0	0	C	210557510	A	C	210557510	3	2	28	1	0	0	0	0	1	0	0	0	9284	43	2	4	630	4	MAP2	2	210557510	Missense_Mutation	SNP	A	TCGA-N8-A4PN-01A-11D-A28R-08	20702666	210557510	32641863	11	2681										
ARPP21	10777	broad.mit.edu	37	chr3	35729358	35729358	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	aacctctgaaaaacccaagaTcagaatgttatcaaaaggtg	7	8	3	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:35729358T>C	ENST00000187397.4	+	6	845	c.389T>C	c.(388-390)aTc>aCc	p.I130T	ARPP21_ENST00000417925.1_Missense_Mutation_p.I130T|ARPP21_ENST00000458225.1_Missense_Mutation_p.I130T|ARPP21_ENST00000444190.1_Missense_Mutation_p.I130T|ARPP21_ENST00000337271.5_Missense_Mutation_p.I130T	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	130						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						AAACCCAAGATCAGAATGTTA	0.338													69	99					0	0	1	0	0	C	35729358	T	C	35729358	3	2	28	1	0	0	0	0	1	0	0	0	977	1435	50	4	416	4	ARPP21	3	35729358	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08		35729358	162293072	12	2682										
PLCD1	5333	broad.mit.edu	37	chr3	38050773	38050773	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	caggcctcacctgattcttgGagcagtcgaagggcacggtt	13	11	2	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:38050773G>A	ENST00000463876.1	-	10	2012	c.1659C>T	c.(1657-1659)ctC>ctT	p.L553L	PLCD1_ENST00000334661.4_Silent_p.L532L	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	532	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CTGATTCTTGGAGCAGTCGAA	0.612													27	126					0	0	1	0	0	A	38050773	G	A	38050773	2	1	28	1	0	0	0	0	0	0	0	1	12078	1161	41	3		3	PLCD1	3	38050773	Silent	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	2321415	38050773	159971657	13	2683										
COL7A1	1294	broad.mit.edu	37	chr3	48613108	48613108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	agtcccccttggggcctcgaCgccgttcgggcacaggcagg	15	15	0	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:48613108C>T	ENST00000328333.8	-	72	6037	c.5930G>A	c.(5929-5931)cGt>cAt	p.R1977H	COL7A1_ENST00000454817.1_Missense_Mutation_p.R1945H	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1977	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGGGCCTCGACGCCGTTCGGG	0.652													23	90					0	0	1	0	0	T	48613108	C	T	48613108	3	4	28	1	0	0	0	0	1	0	0	0	3727	536	19	1	3092	1	COL7A1	3	48613108	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	10562335	48613108	149409322	14	2684										
ARHGEF3	50650	broad.mit.edu	37	chr3	56779411	56779411	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ggaaatcctggactcggtgaTcttgctttttgtggtccagc	12	9	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:56779411T>C	ENST00000413728.2	-	7	1253	c.710A>G	c.(709-711)gAt>gGt	p.D237G	ARHGEF3_ENST00000338458.4_Missense_Mutation_p.D263G|ARHGEF3_ENST00000495373.1_Missense_Mutation_p.D231G|ARHGEF3_ENST00000296315.3_Missense_Mutation_p.D231G|ARHGEF3_ENST00000496106.1_Missense_Mutation_p.D237G|ARHGEF3_ENST00000497267.1_Missense_Mutation_p.D202G	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	231	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		GACTCGGTGATCTTGCTTTTT	0.483													131	313					0	0	1	0	0	C	56779411	T	C	56779411	3	2	28	1	0	0	0	0	1	0	0	0	901	1435	50	4	904	4	ARHGEF3	3	56779411	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08	8166303	56779411	141243019	15	2685										
MAGI1	9223	broad.mit.edu	37	chr3	65425585	65425585	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgctgctgctgctgctgctgCtgctgttgctgctgctgttg	14	11	0	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:65425585C>T	ENST00000330909.8	-	9	1238	c.1239G>A	c.(1237-1239)caG>caA	p.Q413Q	MAGI1_ENST00000483466.1_Silent_p.Q413Q|MAGI1_ENST00000497477.2_Silent_p.Q413Q|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Silent_p.Q413Q	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	413	Poly-Gln.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		gctgctgctgctgctgttgct	0.537											OREG0015658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	159					0	0	1	0	0	T	65425585	C	T	65425585	2	4	28	1	0	0	0	0	0	0	0	1	9239	796	28	3		3	MAGI1	3	65425585	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	8646174	65425585	132596845	16	2686										
SPATA16	83893	broad.mit.edu	37	chr3	172835309	172835309	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tctaaatcattgctttgtttTtctttgatgccctttgtcat	5	8	4	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:172835309T>A	ENST00000351008.3	-	2	396	c.213A>T	c.(211-213)gaA>gaT	p.E71D		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	71					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TGCTTTGTTTTTCTTTGATGC	0.368													29	210					0	0	1	0	0	A	172835309	T	A	172835309	3	1	28	1	0	0	0	0	1	0	0	0	15056	1838	64	4	1536	4	SPATA16	3	172835309	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08	107409724	172835309	25187121	17	2687										
LRRC15	131578	broad.mit.edu	37	chr3	194081584	194081584	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tcattgagttcagtgatgtgCgtgttgaggatctgcaggct	14	6	3	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr3:194081584C>T	ENST00000347624.3	-	2	274	c.189G>A	c.(187-189)acG>acA	p.T63T	LRRC15_ENST00000428839.1_Silent_p.T69T|LRRC15_ENST00000439944.2_Silent_p.T69T	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	63						integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		CAGTGATGTGCGTGTTGAGGA	0.612													27	60					0	0	1	0	0	T	194081584	C	T	194081584	2	4	28	1	0	0	0	0	0	0	0	1	9014	755	27	1		1	LRRC15	3	194081584	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	21246275	194081584	3940846	18	2688										
OTOP1	133060	broad.mit.edu	37	chr4	4204203	4204203	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	atgttcccaaaacccagagtGatgagccgttccttgtgctc	9	12	0	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr4:4204203G>C	ENST00000296358.4	-	4	726	c.702C>G	c.(700-702)atC>atG	p.I234M		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	234					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AACCCAGAGTGATGAGCCGTT	0.517													29	78					0	0	1	0	0	C	4204203	G	C	4204203	3	2	28	1	0	0	0	0	1	0	0	0	11351	1280	45	2	1148	2	OTOP1	4	4204203	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		4204203	186950073	19	2689										
HELQ	113510	broad.mit.edu	37	chr4	84348767	84348767	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cactgtgaaaccagatcataGggggttgttaggtagattag	13	5	1	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr4:84348767G>A	ENST00000295488.3	-	13	2787	c.2625C>T	c.(2623-2625)ccC>ccT	p.P875P	HELQ_ENST00000510985.1_Silent_p.P808P	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	875							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						CCAGATCATAGGGGGTTGTTA	0.373								Other identified genes with known or suspected DNA repair function					59	40					0	0	1	0	0	A	84348767	G	A	84348767	2	1	28	1	0	0	0	0	0	0	0	1	7087	987	35	3		3	HELQ	4	84348767	Silent	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	80144564	84348767	106805509	20	2690										
ANXA5	308	broad.mit.edu	37	chr4	122590823	122590823	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ttcctgatgttaaacagatcAatctcactcctggaaaccat	5	11	2	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr4:122590823A>C	ENST00000296511.5	-	12	1122	c.837T>G	c.(835-837)atT>atG	p.I279M	ANXA5_ENST00000515017.1_Missense_Mutation_p.I179M|ANXA5_ENST00000501272.2_Missense_Mutation_p.I219M	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	279				I -> T (in Ref. 13; AAH18671).	anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						TAAACAGATCAATCTCACTCC	0.358													24	52					0	0	1	0	0	C	122590823	A	C	122590823	3	2	28	1	0	0	0	0	1	0	0	0	715	126	5	4	133	4	ANXA5	4	122590823	Missense_Mutation	SNP	A	TCGA-N8-A4PN-01A-11D-A28R-08	38242056	122590823	68563453	21	2691										
ANKRD50	57182	broad.mit.edu	37	chr4	125591785	125591785	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ttgtgaagctaatatgaaagGgattcgtccatcattgtcaa	9	6	2	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr4:125591785G>T	ENST00000504087.1	-	4	3684	c.2647C>A	c.(2647-2649)Cct>Act	p.P883T	ANKRD50_ENST00000515641.1_Missense_Mutation_p.P704T	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	883										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						AATATGAAAGGGATTCGTCCA	0.373													24	90					6.44725e-10	6.81567e-10	1	1	0	T	125591785	G	T	125591785	3	4	28	1	0	0	0	0	1	0	0	0	671	1232	43	5	1646	5	ANKRD50	4	125591785	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	3000962	125591785	65562491	22	2692										
NR3C2	0	broad.mit.edu	37	chr4	149356963	149356963	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tcccgcaatgtactggatccAgcagaggtgccagaagcagt	12	11	0	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr4:149356963A>G	ENST00000355292.3	-	2	1412	c.1050T>C	c.(1048-1050)gcT>gcC	p.A350A	NR3C2_ENST00000512865.1_Silent_p.A350A|NR3C2_ENST00000511528.1_Silent_p.A350A|NR3C2_ENST00000358102.3_Silent_p.A350A|NR3C2_ENST00000344721.4_Silent_p.A350A|NR3C2_ENST00000342437.4_Silent_p.A350A			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	350	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TACTGGATCCAGCAGAGGTGC	0.522													25	67					0	0	1	0	0	G	149356963	A	G	149356963	2	3	28	1	0	0	0	0	0	0	0	1	10678	175	7	4		4	NR3C2	4	149356963	Silent	SNP	A	TCGA-N8-A4PN-01A-11D-A28R-08	23765178	149356963	41797313	23	2693										
FBXW7	0	broad.mit.edu	37	chr4	153250867	153250867	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cttttaaagtgttgtcatcaGaaccactaactattcggtta	6	8	2	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr4:153250867G>A	ENST00000281708.4	-	8	2422	c.1193C>T	c.(1192-1194)tCt>tTt	p.S398F	FBXW7_ENST00000603548.1_Missense_Mutation_p.S398F|FBXW7_ENST00000603841.1_Missense_Mutation_p.S398F|FBXW7_ENST00000393956.3_Missense_Mutation_p.S222F|FBXW7_ENST00000263981.5_Missense_Mutation_p.S318F|FBXW7_ENST00000296555.5_Missense_Mutation_p.S280F	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	398					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GTTGTCATCAGAACCACTAAC	0.358			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								59	28					0	0	1	0	0	A	153250867	G	A	153250867	3	1	28	1	0	0	0	0	1	0	0	0	5801	942	33	3	950	3	FBXW7	4	153250867	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	3893904	153250867	37903409	24	2694										
PIK3R1	5295	broad.mit.edu	37	chr5	67589585	67589586	+	In_Frame_Ins	INS	-	-	ATG													0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	agctgtagggaaaaaattacINSatgaatataacactcagttt							TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr5:67589585_67589586insATG	ENST00000521381.1	+	11	1964_1965	c.1348_1349insATG	c.(1348-1350)tga>ATGtga	p.449_450insM	PIK3R1_ENST00000521657.1_In_Frame_Ins_p.449_450insM|PIK3R1_ENST00000274335.5_In_Frame_Ins_p.449_450insM|PIK3R1_ENST00000320694.8_In_Frame_Ins_p.149_150insM|PIK3R1_ENST00000396611.1_In_Frame_Ins_p.449_450insM|PIK3R1_ENST00000523872.1_In_Frame_Ins_p.86_87insM|PIK3R1_ENST00000336483.5_In_Frame_Ins_p.179_180insM	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	449					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.H450_E451del(2)|p.G446_Y452>VI(1)|p.0?(1)|p.?(1)|p.E451_Y452delEY(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAAAAAATTACATGAATATAAC	0.282			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			24	21	---	---	---	---						ATG	67589586	-	ATG	67589585	7	5	28	1	0	1	1	0	0	0	0	0	11965	478	17	0	1516	0	PIK3R1	5	67589585	In_Frame_Ins	INS	-	TCGA-N8-A4PN-01A-11D-A28R-08		67589585	113325675	25	2695										
COL11A2	1302	broad.mit.edu	37	chr6	33135298	33135298	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cttccccggggcacctatagCgccaggatctccctgaaaca	9	16	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr6:33135298C>T	ENST00000341947.2	-	56	4254	c.4027G>A	c.(4027-4029)Gct>Act	p.A1343T	COL11A2_ENST00000374714.1_Missense_Mutation_p.A1317T|COL11A2_ENST00000357486.1_Missense_Mutation_p.A1322T|COL11A2_ENST00000361917.1_Missense_Mutation_p.A1236T|COL11A2_ENST00000395197.1_Missense_Mutation_p.A1283T|COL11A2_ENST00000374708.4_Missense_Mutation_p.A1257T|COL11A2_ENST00000374712.1_Missense_Mutation_p.A1262T|COL11A2_ENST00000374713.1_Missense_Mutation_p.A1296T|COL11A2_ENST00000477772.1_Intron	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1343	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GCACCTATAGCGCCAGGATCT	0.652													20	25					0	0	1	0	0	T	33135298	C	T	33135298	3	4	28	1	0	0	0	0	1	0	0	0	3691	768	27	1	1227	1	COL11A2	6	33135298	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		33135298	137979769	26	2696										
PGM3	5238	broad.mit.edu	37	chr6	83896756	83896756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	gacctcctagaacagtcacaCcatctattacagattgtgaa	6	11	2	3	rs80024877		TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr6:83896756C>T	ENST00000513973.1	-	4	544	c.428G>A	c.(427-429)gGt>gAt	p.G143D	PGM3_ENST00000506587.1_Missense_Mutation_p.G171D|PGM3_ENST00000512866.1_Missense_Mutation_p.G143D|PGM3_ENST00000283977.4_Missense_Mutation_p.G62D	NM_001199918.1|NM_015599.2	NP_001186847.1|NP_056414.1	O95394	AGM1_HUMAN	phosphoglucomutase 3	143					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	18		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		AACAGTCACACCATCTATTAC	0.343													10	13					0	0	1	0	0	T	83896756	C	T	83896756	3	4	28	1	0	0	0	0	1	0	0	0	11847	507	18	3	1240	3	PGM3	6	83896756	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	50761458	83896756	87218311	27	2697										
MLLT4	4301	broad.mit.edu	37	chr6	168344722	168344722	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cacccttctcaatcagccatCccccatgatgcagagaagta	6	15	2	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr6:168344722C>G	ENST00000366806.2	+	26	3462	c.3320C>G	c.(3319-3321)tCc>tGc	p.S1107C	MLLT4_ENST00000344191.4_Missense_Mutation_p.S1107C|MLLT4_ENST00000507679.1_3'UTR|MLLT4_ENST00000351017.4_Missense_Mutation_p.S1114C|MLLT4_ENST00000447894.2_Missense_Mutation_p.S1107C|MLLT4_ENST00000400822.3_Missense_Mutation_p.S1106C|MLLT4_ENST00000392112.1_Missense_Mutation_p.S1090C|MLLT4_ENST00000392108.3_Missense_Mutation_p.S1107C			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1107					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AATCAGCCATCCCCCATGATG	0.517			T	MLL	AL								14	52					0	0	1	0	0	G	168344722	C	G	168344722	3	3	28	1	0	0	0	0	1	0	0	0	9676	855	30	2	3418	2	MLLT4	6	168344722	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	84447966	168344722	2770345	28	2698										
MCM4	4173	broad.mit.edu	37	chr8	48873764	48873764	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cggcgtggaagggccaccccCgcccagacgcgtgagtcccc	14	18	0	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr8:48873764C>T	ENST00000262105.2	+	1	269	c.60C>T	c.(58-60)ccC>ccT	p.P20P	MCM4_ENST00000523944.1_Silent_p.P20P	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	20					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GGGCCACCCCCGCCCAGACGC	0.771													5	0					0	0	1	0	0	T	48873764	C	T	48873764	2	4	28	1	0	0	0	0	0	0	0	1	9438	639	23	1		1	MCM4	8	48873764	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		48873764	97490258	29	2699										
PPAPDC2	403313	broad.mit.edu	37	chr9	4662430	4662432	+	In_Frame_Del	DEL	AGC	AGC	-													0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cgctgggcgtctccgcttcgAgcagcagcagcagccccggc							TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr9:4662430_4662432delAGC	ENST00000381883.2	+	1	133_135	c.55_57delAGC	c.(55-57)del	p.S23del	SPATA6L_ENST00000223517.5_Intron|SPATA6L_ENST00000381890.5_Intron|SPATA6L_ENST00000475086.1_Intron|SPATA6L_ENST00000454239.2_Intron|SPATA6L_ENST00000381895.5_Intron	NM_203453.3	NP_982278.3	Q8IY26	PPAC2_HUMAN	phosphatidic acid phosphatase type 2 domain containing 2	23						integral to membrane	hydrolase activity			endometrium(1)|large_intestine(2)|lung(1)	4	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.026)		CTCCGCTTCGAGCAGCAGCAGCA	0.729											OREG0019084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---						-	4662432	AGC	-	4662430	7	5	28	1	0	1	0	1	0	0	0	0	12339	304	11	0	57	0	PPAPDC2	9	4662430	In_Frame_Del	DEL	AGC	TCGA-N8-A4PN-01A-11D-A28R-08		4662430	136551001	30	2700										
TRPM6	140803	broad.mit.edu	37	chr9	77407599	77407599	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ctcatagactttcctggtccAcggaaggtgttggtgcccac	11	12	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr9:77407599A>C	ENST00000451710.3	-	19	2716	c.2479T>G	c.(2479-2481)Tgg>Ggg	p.W827G	TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000360774.1_Missense_Mutation_p.W827G|TRPM6_ENST00000449912.2_Missense_Mutation_p.W822G|TRPM6_ENST00000376864.4_Missense_Mutation_p.W827G|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.W822G			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	827					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTCCTGGTCCACGGAAGGTGT	0.388													20	24					0	0	1	0	0	C	77407599	A	C	77407599	3	2	28	1	0	0	0	0	1	0	0	0	16650	159	6	4	3673	4	TRPM6	9	77407599	Missense_Mutation	SNP	A	TCGA-N8-A4PN-01A-11D-A28R-08	72745169	77407599	63805832	31	2701										
NET1	10276	broad.mit.edu	37	chr10	5471142	5471142	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ttttcttttagaaaagaaaaCgcagagagaaagatgatgat	9	3	1	7			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr10:5471142C>G	ENST00000355029.4	+	3	347	c.205C>G	c.(205-207)Cgc>Ggc	p.R69G	NET1_ENST00000542715.1_5'UTR	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	69	Necessary for nuclear localization (By similarity).				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity	p.R69C(1)		breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						GAAAAGAAAACGCAGAGAGAA	0.323													6	113					0	0	1	0	0	G	5471142	C	G	5471142	3	3	28	1	0	0	0	0	1	0	0	0	10384	536	19	5	215	5	NET1	10	5471142	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		5471142	130063605	32	2702										
CUBN	8029	broad.mit.edu	37	chr10	17130272	17130272	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	caatccagacacaatctcttCctgggggatagtttccagga	9	11	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr10:17130272C>T	ENST00000377833.4	-	15	1903	c.1838G>A	c.(1837-1839)gGa>gAa	p.G613E		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	613	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACAATCTCTTCCTGGGGGATA	0.443													6	56					0	0	1	0	0	T	17130272	C	T	17130272	3	4	28	1	0	0	0	0	1	0	0	0	4074	855	30	3	9245	3	CUBN	10	17130272	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	11659130	17130272	118404475	33	2703										
CHST3	9469	broad.mit.edu	37	chr10	73767358	73767358	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ctcggccctggtgtaccgcgAcgtgctcaagcagctcttcc	11	16	2	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr10:73767358A>T	ENST00000373115.4	+	3	1006	c.569A>T	c.(568-570)gAc>gTc	p.D190V		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	190					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						GTGTACCGCGACGTGCTCAAG	0.652													5	26					0	0	1	0	0	T	73767358	A	T	73767358	3	4	28	1	0	0	0	0	1	0	0	0	3427	275	10	4	575	4	CHST3	10	73767358	Missense_Mutation	SNP	A	TCGA-N8-A4PN-01A-11D-A28R-08	56637086	73767358	61767389	34	2704										
TCF7L2	6934	broad.mit.edu	37	chr10	114919686	114919686	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgaactcattcagacctgagCgctcctaagaaatgccgagc	9	12	2	4			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr10:114919686C>T	ENST00000355995.4	+	14	1884	c.1377C>T	c.(1375-1377)agC>agT	p.S459S	TCF7L2_ENST00000534894.1_Silent_p.S459S|TCF7L2_ENST00000536810.1_Silent_p.S442S|TCF7L2_ENST00000369397.4_Silent_p.S436S|TCF7L2_ENST00000538897.1_Intron|TCF7L2_ENST00000355717.4_Intron|TCF7L2_ENST00000369386.1_Silent_p.S85S|TCF7L2_ENST00000369389.1_Intron|TCF7L2_ENST00000545257.1_Intron|TCF7L2_ENST00000466338.1_Intron|TCF7L2_ENST00000352065.5_Silent_p.S436S|TCF7L2_ENST00000542695.1_Silent_p.S175S|TCF7L2_ENST00000543371.1_Intron			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	459	Promoter-specific activation domain.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CAGACCTGAGCGCTCCTAAGA	0.542			T	VTI1A	colorectal								23	21					0	0	1	0	0	T	114919686	C	T	114919686	2	4	28	1	0	0	0	0	0	0	0	1	15757	767	27	1		1	TCF7L2	10	114919686	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	41152328	114919686	20615061	35	2705										
OR5AS1	219447	broad.mit.edu	37	chr11	55798810	55798810	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	atgctctcaaaaagctattaGaaagaattggatattcaaat	6	5	2	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr11:55798810G>T	ENST00000313555.1	+	1	916	c.916G>T	c.(916-918)Gaa>Taa	p.E306*		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					AAAGCTATTAGAAAGAATTGG	0.308													12	45					3.07112e-06	3.20088e-06	1	1	0	T	55798810	G	T	55798810	4	4	28	1	0	0	0	0	0	1	0	0	11192	943	33	2	918	2	OR5AS1	11	55798810	Nonsense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		55798810	79207706	36	2706										
SHANK2	22941	broad.mit.edu	37	chr11	70505948	70505948	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cctacctcaatcaagaagtcCccggtccttagtccggcttg	8	15	2	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr11:70505948C>G	ENST00000338508.4	-	23	2048	c.2049G>C	c.(2047-2049)ggG>ggC	p.G683G	SHANK2_ENST00000449833.2_Silent_p.G94G|SHANK2_ENST00000449116.2_Silent_p.G94G|SHANK2_ENST00000423696.2_Silent_p.G303G|SHANK2_ENST00000409530.1_Silent_p.G93G|SHANK2_ENST00000409161.1_Silent_p.G93G|SHANK2_ENST00000357171.3_Silent_p.G94G			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	303					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TCAAGAAGTCCCCGGTCCTTA	0.587													16	83					0	0	1	0	0	G	70505948	C	G	70505948	2	3	28	1	0	0	0	0	0	0	0	1	14319	610	22	5		5	SHANK2	11	70505948	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	14707138	70505948	64500568	37	2707										
RAB38	23682	broad.mit.edu	37	chr11	87882875	87882875	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ttcaaaccatcctacgaaacCgtgctccttgcagaactggt	7	13	1	1	rs143951992		TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr11:87882875C>T	ENST00000243662.6	-	2	533	c.451G>A	c.(451-453)Ggt>Agt	p.G151S		NM_022337.2	NP_071732.1	P57729	RAB38_HUMAN	RAB38, member RAS oncogene family	151					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCTACGAAACCGTGCTCCTTG	0.413													22	109					0	0	1	0	0	T	87882875	C	T	87882875	3	4	28	1	0	0	0	0	1	0	0	0	12979	652	23	1	192	1	RAB38	11	87882875	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	17376927	87882875	47123641	38	2708										
ADAMTS8	11095	broad.mit.edu	37	chr11	130289058	130289058	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cagtgtaagccccccattgtCggacacctctgggccccatt	9	16	1	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr11:130289058C>T	ENST00000257359.6	-	2	1556	c.850G>A	c.(850-852)Gac>Aac	p.D284N		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	284	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CCCCCATTGTCGGACACCTCT	0.552													63	336					0	0	1	0	0	T	130289058	C	T	130289058	3	4	28	1	0	0	0	0	1	0	0	0	271	884	31	1	1851	1	ADAMTS8	11	130289058	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	42406183	130289058	4717458	39	2709										
LRRK2	120892	broad.mit.edu	37	chr12	40760879	40760879	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	aaggtacacaaaagcagaaaGgtaacatttagaaggatact	9	5	0	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr12:40760879G>A	ENST00000298910.7	+	50	7520	c.7462_splice	c.e50+1	p.E2488_splice		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2488					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AAAGCAGAAAGGTAACATTTA	0.318													18	32					0	0	1	0	0	A	40760879	G	A	40760879	5	1	28	1	0	0	0	0	0	0	1	0	9077	1014	35	3	7660	3	LRRK2	12	40760879	Splice_Site	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		40760879	93091016	40	2710										
PUS7L	83448	broad.mit.edu	37	chr12	44124455	44124455	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	atgtcatggtaccactgcccTactttgttcttcgggtactg	9	11	2	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr12:44124455T>C	ENST00000416848.2	-	9	2318	c.1830A>G	c.(1828-1830)gtA>gtG	p.V610V	PUS7L_ENST00000551923.1_Silent_p.V610V|PUS7L_ENST00000344862.5_Silent_p.V610V|PUS7L_ENST00000431332.3_Silent_p.V297V	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	610	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		ACCACTGCCCTACTTTGTTCT	0.383													30	33					0	0	1	0	0	C	44124455	T	C	44124455	2	2	28	1	0	0	0	0	0	0	0	1	12885	1509	53	4		4	PUS7L	12	44124455	Silent	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08	3363576	44124455	89727440	41	2711										
APAF1	317	broad.mit.edu	37	chr12	99106175	99106175	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	gttgcttaagtccacatcttCagtacattgcatttggagat	8	8	2	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr12:99106175C>T	ENST00000357310.1	+	20	3368	c.2791C>T	c.(2791-2793)Cag>Tag	p.Q931*	APAF1_ENST00000547045.1_Nonsense_Mutation_p.Q931*|APAF1_ENST00000359972.2_Nonsense_Mutation_p.Q920*|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000550527.1_Nonsense_Mutation_p.Q963*|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000339433.3_Nonsense_Mutation_p.Q931*|APAF1_ENST00000551964.1_Nonsense_Mutation_p.Q974*|APAF1_ENST00000549007.1_Nonsense_Mutation_p.Q931*	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	974					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TCCACATCTTCAGTACATTGC	0.348													16	14					0	0	1	0	0	T	99106175	C	T	99106175	4	4	28	1	0	0	0	0	0	1	0	0	751	827	29	3	2998	3	APAF1	12	99106175	Nonsense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	54981720	99106175	34745720	42	2712										
SLC10A2	6555	broad.mit.edu	37	chr13	103698525	103698525	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cctccatttgccttataaaaCgatgactctggctccgttcc	6	14	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr13:103698525C>T	ENST00000245312.3	-	6	1601	c.1005G>A	c.(1003-1005)tcG>tcA	p.S335S		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	335					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CCTTATAAAACGATGACTCTG	0.368													24	30					0	0	1	0	0	T	103698525	C	T	103698525	2	4	28	1	0	0	0	0	0	0	0	1	14428	523	19	1		1	SLC10A2	13	103698525	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		103698525	11471353	43	2713										
STRC	161497	broad.mit.edu	37	chr15	43896265	43896265	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tcttggcagcaagctgtggcTccctacacagctgtccaact	9	14	1	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr15:43896265T>C	ENST00000450892.2	-	22	4381	c.4304A>G	c.(4303-4305)gAg>gGg	p.E1435G	STRC_ENST00000541030.1_Missense_Mutation_p.E662G	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1435					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AAGCTGTGGCTCCCTACACAG	0.557													6	20					0	0	1	0	0	C	43896265	T	C	43896265	3	2	28	1	0	0	0	0	1	0	0	0	15383	1551	54	4	1055	4	STRC	15	43896265	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08		43896265	58635127	44	2714										
CYP1A1	1543	broad.mit.edu	37	chr15	75014760	75014760	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgggtttccagagccaaccaCctccccgaaattattattca	6	13	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr15:75014760C>T	ENST00000379727.3	-	2	877	c.679G>A	c.(679-681)Gtg>Atg	p.V227M	CYP1A1_ENST00000564596.1_De_novo_Start_InFrame|CYP1A1_ENST00000395049.4_Missense_Mutation_p.V227M|CYP1A1_ENST00000395048.2_Missense_Mutation_p.V227M|CYP1A1_ENST00000567032.1_Missense_Mutation_p.V227M			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	227					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GAGCCAACCACCTCCCCGAAA	0.493									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				20	119					0	0	1	0	0	T	75014760	C	T	75014760	3	4	28	1	0	0	0	0	1	0	0	0	4172	507	18	3	883	3	CYP1A1	15	75014760	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	31118495	75014760	27516632	45	2715										
EEF2K	29904	broad.mit.edu	37	chr16	22278135	22278135	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgggcgagctggaggccatcGtgggcctgggactcatgtac	17	10	1	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr16:22278135G>A	ENST00000263026.5	+	15	2176	c.1702G>A	c.(1702-1704)Gtg>Atg	p.V568M		NM_013302.3	NP_037434.1	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	568					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		GGAGGCCATCGTGGGCCTGGG	0.652													18	64					0	0	1	0	0	A	22278135	G	A	22278135	3	1	28	1	0	0	0	0	1	0	0	0	4956	1145	40	1	1756	1	EEF2K	16	22278135	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		22278135	68076618	46	2716										
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ttccttccactcggataagaTgctgaggaggggccagacct	12	11	0	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr17:7578271T>C	ENST00000420246.2	-	6	710	c.578A>G	c.(577-579)cAt>cGt	p.H193R	TP53_ENST00000269305.4_Missense_Mutation_p.H193R|TP53_ENST00000359597.4_Missense_Mutation_p.H193R|TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.H193R|TP53_ENST00000413465.2_Missense_Mutation_p.H193R|TP53_ENST00000445888.2_Missense_Mutation_p.H193R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(80)|p.H193L(42)|p.H193P(18)|p.0?(8)|p.?(6)|p.H61R(4)|p.H100R(4)|p.H100L(4)|p.H61L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.H193fs*16(3)|p.P191fs*53(2)|p.H61P(2)|p.H100P(2)|p.A189fs*53(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P98_E105>Q(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	7					0	0	1	0	0	C	7578271	T	C	7578271	3	2	28	1	0	0	0	0	1	0	0	0	16441	1464	51	4	716	4	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08		7578271	73616939	47	2717										
CLUL1	27098	broad.mit.edu	37	chr18	641365	641365	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	ctctgcacacagaattagacGaggcgatcaggttggtcaat	11	9	3	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr18:641365G>A	ENST00000581619.1	+	7	1955	c.1108G>A	c.(1108-1110)Gag>Aag	p.E370K	CLUL1_ENST00000400606.2_Missense_Mutation_p.E345K|CLUL1_ENST00000540035.1_Missense_Mutation_p.E397K|C18orf56_ENST00000585033.1_3'UTR|CLUL1_ENST00000579494.1_Missense_Mutation_p.E345K|CLUL1_ENST00000338387.7_Missense_Mutation_p.E345K			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	345					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						AGAATTAGACGAGGCGATCAG	0.488													28	30					0	0	1	0	0	A	641365	G	A	641365	3	1	28	1	0	0	0	0	1	0	0	0	3593	1059	37	1	1055	1	CLUL1	18	641365	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		641365	77435883	48	2718										
TCEB3C	162699	broad.mit.edu	37	chr18	44555262	44555262	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cgagtacaccggcatcttagCgttcactctgcgtccaggga	11	13	3	0			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr18:44555262C>T	ENST00000330682.2	-	1	1187	c.952G>A	c.(952-954)Gct>Act	p.A318T	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	318	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GGCATCTTAGCGTTCACTCTG	0.652													35	328					0	0	1	0	0	T	44555262	C	T	44555262	3	4	28	1	0	0	0	0	1	0	0	0	15742	768	27	1	2335	1	TCEB3C	18	44555262	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	43913897	44555262	33521986	49	2719										
PHLPP1	23239	broad.mit.edu	37	chr18	60609112	60609112	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	acacccccatttgaagatccTtcacatggcctataaccgac	5	15	1	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr18:60609112T>A	ENST00000400316.4	+	11	3367	c.1586T>A	c.(1585-1587)cTt>cAt	p.L529H	PHLPP1_ENST00000262719.5_Missense_Mutation_p.L1041H	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1041					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						TTGAAGATCCTTCACATGGCC	0.408													20	18					0	0	1	0	0	A	60609112	T	A	60609112	3	1	28	1	0	0	0	0	1	0	0	0	11901	1609	56	4	3164	4	PHLPP1	18	60609112	Missense_Mutation	SNP	T	TCGA-N8-A4PN-01A-11D-A28R-08	16053850	60609112	17468136	50	2720										
MUC16	94025	broad.mit.edu	37	chr19	9012504	9012504	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	tgcagccagagtacagaaggCcgacactggtgttcttgaac	12	10	1	3			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr19:9012504C>A	ENST00000397910.4	-	35	38905	c.38702G>T	c.(38701-38703)gGc>gTc	p.G12901V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12903	SEA 6.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTACAGAAGGCCGACACTGGT	0.537													40	106					4.14481e-20	4.44516e-20	1	1	0	A	9012504	C	A	9012504	3	1	28	1	0	0	0	0	1	0	0	0	10020	739	26	5	5021	5	MUC16	19	9012504	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		9012504	50116479	51	2721										
ACTN4	81	broad.mit.edu	37	chr19	39198795	39198795	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cttcaatgccctgatccaccGgcacagaccagagctgattg	9	14	1	4			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr19:39198795G>A	ENST00000252699.2	+	6	687	c.611G>A	c.(610-612)cGg>cAg	p.R204Q	ACTN4_ENST00000390009.3_Intron|ACTN4_ENST00000424234.2_Intron	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	204	Actin-binding.|CH 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTGATCCACCGGCACAGACCA	0.567													42	93					0	0	1	0	0	A	39198795	G	A	39198795	3	1	28	1	0	0	0	0	1	0	0	0	207	1116	39	1	633	1	ACTN4	19	39198795	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08	30186291	39198795	19930188	52	2722										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715982	52715982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	atgacacccccatggtgcggCgggccgcagcctccaagctg	13	16	0	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr19:52715982C>T	ENST00000322088.6	+	5	605	c.547C>T	c.(547-549)Cgg>Tgg	p.R183W	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.R128W|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.R4W	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	183	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183W(22)|p.R183G(2)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CATGGTGCGGCGGGCCGCAGC	0.617			Mis		clear cell ovarian carcinoma								32	68					0	0	1	0	0	T	52715982	C	T	52715982	3	4	28	1	0	0	0	0	1	0	0	0	12430	759	27	1	565	1	PPP2R1A	19	52715982	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	13517187	52715982	6413001	53	2723										
NKAIN4	128414	broad.mit.edu	37	chr20	61875393	61875393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	cacagctgtcctcttcctccGtaaacacgctgaccacctgg	7	17	1	1	rs141841184		TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr20:61875393G>A	ENST00000370316.3	-	5	604	c.515C>T	c.(514-516)aCg>aTg	p.T172M	NKAIN4_ENST00000370313.1_Missense_Mutation_p.T110M|NKAIN4_ENST00000466885.1_5'UTR|NKAIN4_ENST00000370307.2_Missense_Mutation_p.T110M	NM_152864.3	NP_690603.3	Q8IVV8	NKAI4_HUMAN	Na+/K+ transporting ATPase interacting 4	172						integral to membrane|plasma membrane				endometrium(2)|lung(1)|ovary(1)	4	all_cancers(38;2.72e-09)					CTCTTCCTCCGTAAACACGCT	0.637													4	45					0	0	1	0	0	A	61875393	G	A	61875393	3	1	28	1	0	0	0	0	1	0	0	0	10484	1145	40	1	123	1	NKAIN4	20	61875393	Missense_Mutation	SNP	G	TCGA-N8-A4PN-01A-11D-A28R-08		61875393	1150127	54	2724										
MCHR1	0	broad.mit.edu	37	chr22	41077056	41077056	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	atcgggaactccacggtcatCttcgcggtcgtgaagaagtc	12	11	2	2			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chr22:41077056C>T	ENST00000249016.4	+	2	1089	c.393C>T	c.(391-393)atC>atT	p.I131I	MCHR1_ENST00000381433.2_Silent_p.I131I|MCHR1_ENST00000498400.1_3'UTR	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	131					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CCACGGTCATCTTCGCGGTCG	0.557													21	58					0	0	1	0	0	T	41077056	C	T	41077056	2	4	28	1	0	0	0	0	0	0	0	1	9431	903	32	3		3	MCHR1	22	41077056	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		41077056	10227510	55	2725										
SCML1	6322	broad.mit.edu	37	chrX	17770059	17770059	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	acagatcctcttgcattatgCcctcttgtcgacctcttcag	6	14	4	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chrX:17770059C>T	ENST00000380043.3	+	6	1075	c.747C>T	c.(745-747)tgC>tgT	p.C249C	SCML1_ENST00000398080.1_Silent_p.C155C|SCML1_ENST00000380045.3_Silent_p.C155C|SCML1_ENST00000380041.3_Silent_p.C276C	NM_006746.4	NP_006737.2	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 (Drosophila)	276					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)	10	Hepatocellular(33;0.183)					TTGCATTATGCCCTCTTGTCG	0.448													5	406					0	0	1	0	0	T	17770059	C	T	17770059	2	4	28	1	0	0	0	0	0	0	0	1	13962	747	26	3		3	SCML1	23	17770059	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08		17770059	137500501	56	2726										
MAGEB2	4113	broad.mit.edu	37	chrX	30236898	30236898	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	gagcctcagagagccccaacCactgccgctgctgcggctgc	12	17	1	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chrX:30236898C>A	ENST00000378988.4	+	2	302	c.201C>A	c.(199-201)acC>acA	p.T67T		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	67							protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						GAGCCCCAACCACTGCCGCTG	0.562													5	9					0.014758	0.014758	1	1	0	A	30236898	C	A	30236898	2	1	28	1	0	0	0	0	0	0	0	1	9225	581	21	5		5	MAGEB2	23	30236898	Silent	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	12466839	30236898	125033662	57	2727										
KDM6A	7403	broad.mit.edu	37	chrX	44922731	44922731	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.103448275862069	6	1	1.07362534948742	1.32413793103448	1.03448275862069	0.118881118881119	0.651583710407241	0	taatgggccaacagctgactCatcactgcctacaaactcag	7	13	3	1			TCGA-N8-A4PN-01A-11D-A28R-08	TCGA-N8-A4PN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	76c6bebb-add9-4a40-96bc-5063289d5e64	4e82a82d-6ec4-4b31-9bfc-1d86f4436235	g.chrX:44922731C>T	ENST00000377967.4	+	16	1633	c.1592C>T	c.(1591-1593)tCa>tTa	p.S531L	KDM6A_ENST00000543216.1_Missense_Mutation_p.S452L|KDM6A_ENST00000382899.4_Missense_Mutation_p.S538L|KDM6A_ENST00000536777.1_Missense_Mutation_p.S486L	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	531					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						ACAGCTGACTCATCACTGCCT	0.522			"D, N, F, S"		"renal, oesophageal SCC, MM"								29	32					0	0	1	0	0	T	44922731	C	T	44922731	3	4	28	1	0	0	0	0	1	0	0	0	8179	838	29	3	1654	3	KDM6A	23	44922731	Missense_Mutation	SNP	C	TCGA-N8-A4PN-01A-11D-A28R-08	14685833	44922731	110347829	58	2728										
CHD5	26038	broad.mit.edu	37	chr1	6209463	6209463	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ggtctgtctcatagccgtcaCcatcatcaactagggtaggg	11	11	5	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:6209463C>G	ENST00000262450.3	-	8	1103	c.1004G>C	c.(1003-1005)gGt>gCt	p.G335A	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	335					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ATAGCCGTCACCATCATCAAC	0.582													15	21					0	0	1	0	0	G	6209463	C	G	6209463	3	3	29	1	0	0	0	0	1	0	0	0	3350	507	18	5	4996	5	CHD5	1	6209463	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		6209463	243041158	1	2729										
PDE4DIP	9659	broad.mit.edu	37	chr1	144855783	144855783	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgtgggtgcttggcagggccGctctccagaacatggtgagg	17	9	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:144855783G>A	ENST00000369359.4	-	44	7216	c.7178C>T	c.(7177-7179)gCg>gTg	p.A2393V	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.A2257V|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.A2257V|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.A2151V|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.A2342V			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2257					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.A2257V(2)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGGCAGGGCCGCTCTCCAGAA	0.572			T	PDGFRB	MPD								6	69					0	0	1	0	0	A	144855783	G	A	144855783	3	1	29	1	0	0	0	0	1	0	0	0	11689	1087	38	1	286	1	PDE4DIP	1	144855783	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	138646320	144855783	104394838	2	2730										
PDE4DIP	9659	broad.mit.edu	37	chr1	145015930	145015930	+	Frame_Shift_Del	DEL	T	T	-													0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atgctctcaaggaatatgtcTgcacaaacgggaccttttca							TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:145015930delT	ENST00000369359.4	-	3	409	c.371delA	c.(370-372)cgfs	p.Q124fs	PDE4DIP_ENST00000369348.3_Frame_Shift_Del_p.Q124fs|PDE4DIP_ENST00000530740.1_Frame_Shift_Del_p.Q124fs|PDE4DIP_ENST00000313382.9_Frame_Shift_Del_p.Q53fs|PDE4DIP_ENST00000493130.2_Frame_Shift_Del_p.Q53fs|PDE4DIP_ENST00000478649.2_Frame_Shift_Del_p.Q53fs			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GGAATATGTCTGCACAAACGG	0.453			T	PDGFRB	MPD								19	657	---	---	---	---						-	145015930	T	-	145015930	7	5	29	1	0	1	0	1	0	0	0	0	11689	1580	55	0	8433	0	PDE4DIP	1	145015930	Frame_Shift_Del	DEL	T	TCGA-N8-A4PO-01A-11D-A28R-08	160147	145015930	104234691	3	2731										
ITGA10	8515	broad.mit.edu	37	chr1	145538291	145538291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cctacatccaatatgagcccCacctcctgttctctaggtat	5	15	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:145538291C>T	ENST00000369304.3	+	23	2993	c.2818C>T	c.(2818-2820)Cac>Tac	p.H940Y	ITGA10_ENST00000539363.1_Missense_Mutation_p.H797Y|ITGA10_ENST00000538811.1_Missense_Mutation_p.H809Y	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	940					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATATGAGCCCCACCTCCTGTT	0.552													47	122					0	0	1	0	0	T	145538291	C	T	145538291	3	4	29	1	0	0	0	0	1	0	0	0	7916	594	21	3	2908	3	ITGA10	1	145538291	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	522361	145538291	103712330	4	2732										
ARHGEF2	9181	broad.mit.edu	37	chr1	155920676	155920676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgcggggaggctgcgccgccGaggatccacaggtctgcggg	19	12	1	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:155920676G>A	ENST00000368316.1	-	24	3033	c.2563C>T	c.(2563-2565)Cgg>Tgg	p.R855W	ARHGEF2_ENST00000368315.3_Missense_Mutation_p.R884W|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.R855W|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.R882W|ARHGEF2_ENST00000361247.4_Missense_Mutation_p.R883W			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	883					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTGCGCCGCCGAGGATCCACA	0.677													36	151					0	0	1	0	0	A	155920676	G	A	155920676	3	1	29	1	0	0	0	0	1	0	0	0	900	1057	37	1	325	1	ARHGEF2	1	155920676	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	10382385	155920676	93329945	5	2733										
LRRN2	10446	broad.mit.edu	37	chr1	204588892	204588892	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	acggacaatgctgttgctctGcaggagcagggtctgtgtgc	15	9	2	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:204588892G>A	ENST00000367175.1	-	1	2441	c.229C>T	c.(229-231)Cag>Tag	p.Q77*	LRRN2_ENST00000367176.3_Nonsense_Mutation_p.Q77*|LRRN2_ENST00000367177.3_Nonsense_Mutation_p.Q77*			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	77					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CTGTTGCTCTGCAGGAGCAGG	0.617													5	94					0	0	1	0	0	A	204588892	G	A	204588892	4	1	29	1	0	0	0	0	0	1	0	0	9079	1328	46	3	1916	3	LRRN2	1	204588892	Nonsense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	48668216	204588892	44661729	6	2734										
RYR2	6262	broad.mit.edu	37	chr1	237586402	237586402	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ttttcattaggtggagtggaAgccacataagatggggacag	14	5	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:237586402A>T	ENST00000366574.2	+	12	1176	c.859A>T	c.(859-861)Agc>Tgc	p.S287C	RYR2_ENST00000360064.6_Missense_Mutation_p.S285C|RYR2_ENST00000542537.1_Missense_Mutation_p.S271C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	287	MIR 4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.S285G(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGGAGTGGAAGCCACATAAG	0.423													4	131					0	0	1	0	0	T	237586402	A	T	237586402	3	4	29	1	0	0	0	0	1	0	0	0	13820	72	3	4	905	4	RYR2	1	237586402	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	32997510	237586402	11664219	7	2735										
RYR2	6262	broad.mit.edu	37	chr1	237870323	237870323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	agaaactcatggaagaaatcGtggaattagccgagtccggc	12	8	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr1:237870323G>A	ENST00000366574.2	+	68	9972	c.9655G>A	c.(9655-9657)Gtg>Atg	p.V3219M	RYR2_ENST00000360064.6_Missense_Mutation_p.V3217M|RYR2_ENST00000542537.1_Missense_Mutation_p.V3203M	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3219					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAAGAAATCGTGGAATTAGC	0.448													19	161					0	0	1	0	0	A	237870323	G	A	237870323	3	1	29	1	0	0	0	0	1	0	0	0	13820	1145	40	1	9925	1	RYR2	1	237870323	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	283921	237870323	11380298	8	2736										
C2orf16	84226	broad.mit.edu	37	chr2	27803080	27803080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ttccaagagtcctacttccaCaatagatttgcagtctgggc	8	11	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr2:27803080C>T	ENST00000408964.2	+	1	3692	c.3641C>T	c.(3640-3642)aCa>aTa	p.T1214I		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1214										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CCTACTTCCACAATAGATTTG	0.463													34	67					0	0	1	0	0	T	27803080	C	T	27803080	3	4	29	1	0	0	0	0	1	0	0	0	2171	478	17	3	3643	3	C2orf16	2	27803080	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		27803080	215396293	9	2737										
ALK	238	broad.mit.edu	37	chr2	29450452	29450452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gaagctaccttttaaagctgGggtgtacaggatgcccagtg	13	8	0	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr2:29450452G>A	ENST00000389048.3	-	17	3808	c.2902C>T	c.(2902-2904)Cca>Tca	p.P968S	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	968					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TTTAAAGCTGGGGTGTACAGG	0.517			"T, Mis, A"	"NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"	"ALCL, NSCLC, Neuroblastoma"	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				17	113					0	0	1	0	0	A	29450452	G	A	29450452	3	1	29	1	0	0	0	0	1	0	0	0	521	1232	43	3	2012	3	ALK	2	29450452	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	1647372	29450452	213748921	10	2738										
SFTPB	6439	broad.mit.edu	37	chr2	85890855	85890855	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ccagctggggcagcatgcggCccagcagcgtgtcgagcagg	17	13	0	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr2:85890855C>A	ENST00000393822.3	-	8	923	c.824G>T	c.(823-825)gGc>gTc	p.G275V	SFTPB_ENST00000409383.1_Missense_Mutation_p.G275V|SFTPB_ENST00000342375.3_Missense_Mutation_p.G263V|SFTPB_ENST00000519937.2_Missense_Mutation_p.G263V			P07988	PSPB_HUMAN	surfactant protein B	263	Saposin B-type 2.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)	16						CAGCATGCGGCCCAGCAGCGT	0.682													3	20					1	1	1	1	0	A	85890855	C	A	85890855	3	1	29	1	0	0	0	0	1	0	0	0	14244	739	26	5	373	5	SFTPB	2	85890855	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	56440403	85890855	157308518	11	2739										
PROM2	150696	broad.mit.edu	37	chr2	95954317	95954317	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aagacctccaaatacttccgTcctatccggaaacgcctcag	6	15	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr2:95954317T>C	ENST00000317620.9	+	22	2554	c.2421T>C	c.(2419-2421)cgT>cgC	p.R807R	PROM2_ENST00000317668.4_Silent_p.R807R|PROM2_ENST00000403131.2_Silent_p.R807R|PROM2_ENST00000542147.1_Silent_p.R758R	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	807						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						AATACTTCCGTCCTATCCGGA	0.602													6	127					0	0	1	0	0	C	95954317	T	C	95954317	2	2	29	1	0	0	0	0	0	0	0	1	12607	1654	58	4		4	PROM2	2	95954317	Silent	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	10063462	95954317	147245056	12	2740										
ANKAR	150709	broad.mit.edu	37	chr2	190606164	190606164	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gctctgctatcatttgtactCgggaatagaagaggtaaaaa	10	6	2	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr2:190606164C>T	ENST00000520309.1	+	20	3885	c.3797C>T	c.(3796-3798)tCg>tTg	p.S1266L	ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000313581.4_Missense_Mutation_p.S1266L|ANKAR_ENST00000431575.2_Missense_Mutation_p.S1195L	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1266						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			CATTTGTACTCGGGAATAGAA	0.358													38	18					0	0	1	0	0	T	190606164	C	T	190606164	3	4	29	1	0	0	0	0	1	0	0	0	619	893	31	1	3871	1	ANKAR	2	190606164	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	94651847	190606164	52593209	13	2741										
FBLN2	2199	broad.mit.edu	37	chr3	13612329	13612329	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gttcacctgccgccctgccgGgcctgccactgccctgacgc	11	20	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr3:13612329G>T	ENST00000404922.3	+	2	593	c.474G>T	c.(472-474)cgG>cgT	p.R158R	FBLN2_ENST00000295760.7_Silent_p.R158R|FBLN2_ENST00000535798.1_Silent_p.R184R|FBLN2_ENST00000492059.1_Silent_p.R158R	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	158	N.|Subdomain NA (Cys-rich).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CGCCCTGCCGGGCCTGCCACT	0.687													11	27					0.010729	0.0111724	1	1	0	T	13612329	G	T	13612329	2	4	29	1	0	0	0	0	0	0	0	1	5731	1219	43	5		5	FBLN2	3	13612329	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08		13612329	184410101	14	2742										
PRR23B	389151	broad.mit.edu	37	chr3	138739287	138739287	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	caccaggtcgacgtcgtccaGgggcacacgcagggcacagc	14	15	0	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr3:138739287G>C	ENST00000329447.5	-	1	481	c.217C>G	c.(217-219)Ctg>Gtg	p.L73V	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	73										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACGTCGTCCAGGGGCACACGC	0.701													6	58					0	0	1	0	0	C	138739287	G	C	138739287	3	2	29	1	0	0	0	0	1	0	0	0	12645	991	35	5	584	5	PRR23B	3	138739287	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	125126958	138739287	59283143	15	2743										
ATP11B	23200	broad.mit.edu	37	chr3	182559896	182559896	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atgatcataacccaacaaatGgaagaaattgtaaggtaaga	8	5	1	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr3:182559896G>T	ENST00000323116.5	+	8	950	c.690G>T	c.(688-690)atG>atT	p.M230I	ATP11B_ENST00000482794.1_3'UTR	NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	230					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			CCCAACAAATGGAAGAAATTG	0.318													4	36					1	1	1	1	0	T	182559896	G	T	182559896	3	4	29	1	0	0	0	0	1	0	0	0	1119	1348	47	5	720	5	ATP11B	3	182559896	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	43820609	182559896	15462534	16	2744										
ATP13A4	84239	broad.mit.edu	37	chr3	193188759	193188759	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atctccaggcaccaggacgcGtgattccagctcttgaactc	9	14	2	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr3:193188759G>T	ENST00000342695.4	-	9	1154	c.832C>A	c.(832-834)Cgc>Agc	p.R278S	ATP13A4_ENST00000295548.3_Missense_Mutation_p.R278S|ATP13A4_ENST00000392443.3_Missense_Mutation_p.R278S	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	278					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		ACCAGGACGCGTGATTCCAGC	0.443													29	220					1.13719e-10	1.29086e-10	1	1	0	T	193188759	G	T	193188759	3	4	29	1	0	0	0	0	1	0	0	0	1125	1145	40	5	2846	5	ATP13A4	3	193188759	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	10628863	193188759	4833671	17	2745										
MUC4	4585	broad.mit.edu	37	chr3	195510912	195510912	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gagggagtgtcggtgacaggTagaggggtggtgtgacctgt	21	4	0	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr3:195510912T>A	ENST00000463781.3	-	2	7998	c.7539A>T	c.(7537-7539)ctA>ctT	p.L2513L	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.L2513L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	272					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CGGTGACAGGTAGAGGGGTGG	0.562													3	10					0	0	1	0	0	A	195510912	T	A	195510912	2	1	29	1	0	0	0	0	0	0	0	1	10025	1625	57	4		4	MUC4	3	195510912	Silent	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	2322153	195510912	2511518	18	2746										
MUC4	4585	broad.mit.edu	37	chr3	195511689	195511689	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tcggtgacaggaagaggggtGgtgtcacctgtggatgctga	18	6	1	3	rs71634713		TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr3:195511689G>T	ENST00000463781.3	-	2	7221	c.6762C>A	c.(6760-6762)acC>acA	p.T2254T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.T2254T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1037					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAAGAGGGGTGGTGTCACCTG	0.582													3	21					0.004672	0.0049056	1	1	0	T	195511689	G	T	195511689	2	4	29	1	0	0	0	0	0	0	0	1	10025	1335	47	5		5	MUC4	3	195511689	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	777	195511689	2510741	19	2747										
NR3C2	0	broad.mit.edu	37	chr4	149357868	149357868	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aatagcaccggaaacacagcTtacgttgacaatctccatgt	7	11	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr4:149357868T>C	ENST00000355292.3	-	2	507	c.145A>G	c.(145-147)Agc>Ggc	p.S49G	NR3C2_ENST00000512865.1_Missense_Mutation_p.S49G|NR3C2_ENST00000511528.1_Missense_Mutation_p.S49G|NR3C2_ENST00000358102.3_Missense_Mutation_p.S49G|NR3C2_ENST00000344721.4_Missense_Mutation_p.S49G|NR3C2_ENST00000342437.4_Missense_Mutation_p.S49G			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	49	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GAAACACAGCTTACGTTGACA	0.483													19	44					0	0	1	0	0	C	149357868	T	C	149357868	3	2	29	1	0	0	0	0	1	0	0	0	10678	1609	56	4	2841	4	NR3C2	4	149357868	Missense_Mutation	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08		149357868	41796408	20	2748										
SLC12A7	10723	broad.mit.edu	37	chr5	1075524	1075524	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ttgtagatgcagccagcgatGagcatggcggacagcgcgta	15	9	0	2	rs137990661	byFrequency	TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr5:1075524G>A	ENST00000264930.5	-	15	1972	c.1929C>T	c.(1927-1929)ctC>ctT	p.L643L		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	643					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	AGCCAGCGATGAGCATGGCGG	0.637													30	62					0	0	1	0	0	A	1075524	G	A	1075524	2	1	29	1	0	0	0	0	0	0	0	1	14442	1277	45	3		3	SLC12A7	5	1075524	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08		1075524	179839736	21	2749										
TRIO	7204	broad.mit.edu	37	chr5	14487604	14487604	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ccaatcgagtaccagaggaaCcacagcgggggcggcggcgg	17	12	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr5:14487604C>G	ENST00000344204.4	+	48	6891	c.6867C>G	c.(6865-6867)aaC>aaG	p.N2289K	TRIO_ENST00000537187.1_Missense_Mutation_p.N2289K	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2289					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					ACCAGAGGAACCACAgcgggg	0.746													4	36					0	0	1	0	0	G	14487604	C	G	14487604	3	3	29	1	0	0	0	0	1	0	0	0	16612	506	18	5	7057	5	TRIO	5	14487604	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	13412080	14487604	166427656	22	2750										
SLCO4C1	353189	broad.mit.edu	37	chr5	101576467	101576467	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tattcccaaggctagggaccGttgtctgtgattaacacacc	9	11	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr5:101576467G>T	ENST00000310954.6	-	11	2117	c.1831C>A	c.(1831-1833)Cgg>Agg	p.R611R		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	611					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GCTAGGGACCGTTGTCTGTGA	0.338													26	30					2.61193e-14	3.07573e-14	1	1	0	T	101576467	G	T	101576467	2	4	29	1	0	0	0	0	0	0	0	1	14784	1144	40	5		5	SLCO4C1	5	101576467	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	87088863	101576467	79338793	23	2751										
SLC27A6	28965	broad.mit.edu	37	chr5	128362947	128362947	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tttaagaagggagatgtttaCcttaatactggagacttaat	9	4	0	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr5:128362947C>G	ENST00000262462.4	+	7	2387	c.1377C>G	c.(1375-1377)taC>taG	p.Y459*	SLC27A6_ENST00000395266.1_Nonsense_Mutation_p.Y459*|SLC27A6_ENST00000506176.1_Nonsense_Mutation_p.Y459*			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	459					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GAGATGTTTACCTTAATACTG	0.388													21	60					0	0	1	0	0	G	128362947	C	G	128362947	4	3	29	1	0	0	0	0	0	1	0	0	14584	518	18	5	1403	5	SLC27A6	5	128362947	Nonsense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	26786480	128362947	52552313	24	2752										
CDYL	9425	broad.mit.edu	37	chr6	4892429	4892429	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cctgagaaactggaccccgtCgagcagggtcaggaggacac	14	12	1	1	rs145508163		TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:4892429C>T	ENST00000328908.5	+	4	800	c.669C>T	c.(667-669)gtC>gtT	p.V223V	CDYL_ENST00000343762.5_Silent_p.V37V|CDYL_ENST00000449732.2_Silent_p.V37V|CDYL_ENST00000397588.3_Silent_p.V169V|CDYL_ENST00000472453.1_Intron			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	223					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		TGGACCCCGTCGAGCAGGGTC	0.617													4	97					0	0	1	0	0	T	4892429	C	T	4892429	2	4	29	1	0	0	0	0	0	0	0	1	3207	871	31	1		1	CDYL	6	4892429	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		4892429	166222638	25	2753										
KDM1B	221656	broad.mit.edu	37	chr6	18215312	18215312	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aggaccctggatgacaaacaGgtgctgcagcagtgcatggc	14	10	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:18215312G>C	ENST00000388870.2	+	20	2428	c.2187G>C	c.(2185-2187)caG>caC	p.Q729H	KDM1B_ENST00000397244.1_Missense_Mutation_p.Q497H|KDM1B_ENST00000546309.2_Missense_Mutation_p.Q19H|KDM1B_ENST00000297792.5_Missense_Mutation_p.Q496H			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	728					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						ATGACAAACAGGTGCTGCAGC	0.577													7	56					0	0	1	0	0	C	18215312	G	C	18215312	3	2	29	1	0	0	0	0	1	0	0	0	8166	991	35	5	1542	5	KDM1B	6	18215312	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	13322883	18215312	152899755	26	2754										
KIFC1	3833	broad.mit.edu	37	chr6	33371611	33371611	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgcagaactaaaacggtgccGtgagaggactcaaacgttgg	13	8	1	2	rs146314962		TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:33371611G>A	ENST00000428849.2	+	6	911	c.461G>A	c.(460-462)cGt>cAt	p.R154H	KIFC1_ENST00000486695.1_3'UTR	NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	154					blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						AAACGGTGCCGTGAGAGGACT	0.552													14	203					0	0	1	0	0	A	33371611	G	A	33371611	3	1	29	1	0	0	0	0	1	0	0	0	8353	1145	40	1	483	1	KIFC1	6	33371611	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	15156299	33371611	137743456	27	2755										
HCRTR2	3062	broad.mit.edu	37	chr6	55113469	55113469	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgtggaagaaccaccacatgAggacggtaaccaactacttc	9	11	0	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:55113469A>G	ENST00000370862.3	+	2	592	c.256A>G	c.(256-258)Agg>Ggg	p.R86G		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	86					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCACCACATGAGGACGGTAAC	0.448													17	125					0	0	1	0	0	G	55113469	A	G	55113469	3	3	29	1	0	0	0	0	1	0	0	0	7042	295	11	4	262	4	HCRTR2	6	55113469	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	21741858	55113469	116001598	28	2756										
PHF3	23469	broad.mit.edu	37	chr6	64394337	64394337	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gatggattagattctaagcaTaagtgtaataatccgggaga	11	4	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:64394337T>C	ENST00000262043.3	+	4	1054	c.714T>C	c.(712-714)caT>caC	p.H238H	PHF3_ENST00000509330.1_Silent_p.H238H|PHF3_ENST00000393387.1_Silent_p.H238H			Q92576	PHF3_HUMAN	PHD finger protein 3	238					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			ATTCTAAGCATAAGTGTAATA	0.348													4	122					0	0	1	0	0	C	64394337	T	C	64394337	2	2	29	1	0	0	0	0	0	0	0	1	11883	1403	49	4		4	PHF3	6	64394337	Silent	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	9280868	64394337	106720730	29	2757										
LYRM2	57226	broad.mit.edu	37	chr6	90348404	90348404	+	Frame_Shift_Del	DEL	A	A	-													0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ccggtacctgctttaacgttAgcgtcgctgggggtaagcgg							TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:90348404delA	ENST00000523377.1	-	1	68	c.32delT	c.(31-33)cafs	p.L11fs	LYRM2_ENST00000520441.1_Frame_Shift_Del_p.L11fs|LYRM2_ENST00000520318.1_Frame_Shift_Del_p.L11fs	NM_020466.4	NP_065199.1	Q9NU23	LYRM2_HUMAN	LYR motif containing 2	11										kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)		CTTTAACGTTAGCGTCGCTGG	0.632													11	404	---	---	---	---						-	90348404	A	-	90348404	7	5	29	1	0	1	0	1	0	0	0	0	9165	420	15	0	246	0	LYRM2	6	90348404	Frame_Shift_Del	DEL	A	TCGA-N8-A4PO-01A-11D-A28R-08	25954067	90348404	80766663	30	2758										
ULBP2	80328	broad.mit.edu	37	chr6	150267593	150267593	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tggcagttcagtttcgatggGcagatcttcctcctctttga	10	10	3	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:150267593G>A	ENST00000367351.3	+	3	508	c.435G>A	c.(433-435)ggG>ggA	p.G145G		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	145	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		GTTTCGATGGGCAGATCTTCC	0.507													105	123					0	0	1	0	0	A	150267593	G	A	150267593	2	1	29	1	0	0	0	0	0	0	0	1	17032	1190	42	3		3	ULBP2	6	150267593	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	59919189	150267593	20847474	31	2759										
ULBP2	80328	broad.mit.edu	37	chr6	150267643	150267643	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gagaatgtggacaacggttcAtcctggagccagaaagatga	13	7	1	4			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:150267643A>C	ENST00000367351.3	+	3	558	c.485A>C	c.(484-486)cAt>cCt	p.H162P		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	162	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		ACAACGGTTCATCCTGGAGCC	0.473													32	182					0	0	1	0	0	C	150267643	A	C	150267643	3	2	29	1	0	0	0	0	1	0	0	0	17032	217	8	4	495	4	ULBP2	6	150267643	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	50	150267643	20847424	32	2760										
MAP3K4	4216	broad.mit.edu	37	chr6	161529829	161529829	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aggaaactgcagacgaattgAaaatattcgaaggcatcaaa	9	6	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr6:161529829A>C	ENST00000392142.4	+	22	4322	c.4174A>C	c.(4174-4176)Aaa>Caa	p.K1392Q	MAP3K4_ENST00000348824.7_Missense_Mutation_p.K1338Q|MAP3K4_ENST00000366919.2_Missense_Mutation_p.K1342Q|MAP3K4_ENST00000366920.2_Missense_Mutation_p.K1388Q	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1392	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGACGAATTGAAAATATTCGA	0.408													82	77					0	0	1	0	0	C	161529829	A	C	161529829	3	2	29	1	0	0	0	0	1	0	0	0	9301	247	9	4	4260	4	MAP3K4	6	161529829	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	11262186	161529829	9585238	33	2761										
EEPD1	80820	broad.mit.edu	37	chr7	36194058	36194058	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gaatcaggagcggctcaacaTcaacactgccacggaggagg	13	11	3	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr7:36194058T>G	ENST00000242108.4	+	2	843	c.125T>G	c.(124-126)aTc>aGc	p.I42S	EEPD1_ENST00000534978.1_Missense_Mutation_p.I42S	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	42	HhH.				DNA repair		DNA binding			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						CGGCTCAACATCAACACTGCC	0.597													80	61					0	0	1	0	0	G	36194058	T	G	36194058	3	3	29	1	0	0	0	0	1	0	0	0	4958	1435	50	4	127	4	EEPD1	7	36194058	Missense_Mutation	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08		36194058	122944605	34	2762										
ZAN	7455	broad.mit.edu	37	chr7	100355878	100355878	+	RNA	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gaacattgccgctgctggccCggcagtcgggtcgagtgcca	15	13	0	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr7:100355878C>T	ENST00000542585.1	+	0	3511				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCTGCTGGCCCGGCAGTCGGG	0.587													10	36					0	0	1	0	0	T	100355878	C	T	100355878	1	4	29	0	1	0	0	0	0	0	0	0	17572	639	23	1		1	ZAN	7	100355878	RNA	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	64161820	100355878	58782785	35	2763										
NCAPG2	54892	broad.mit.edu	37	chr7	158468184	158468184	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cttaccttaaagacagaacaAcgaacatcagctgagctcgt	7	11	1	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr7:158468184A>G	ENST00000409339.3	-	12	1424	c.1311T>C	c.(1309-1311)cgT>cgC	p.R437R	NCAPG2_ENST00000356309.3_Silent_p.R437R|NCAPG2_ENST00000449727.2_Silent_p.R437R|NCAPG2_ENST00000275830.10_Silent_p.R229R|NCAPG2_ENST00000409423.1_Silent_p.R437R			Q86XI2	CNDG2_HUMAN	non-SMC condensin II complex, subunit G2	437					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		AGACAGAACAACGAACATCAG	0.348													12	22					0	0	1	0	0	G	158468184	A	G	158468184	2	3	29	1	0	0	0	0	0	0	0	1	10254	30	2	4		4	NCAPG2	7	158468184	Silent	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	58112306	158468184	670479	36	2764										
CSMD1	64478	broad.mit.edu	37	chr8	3216672	3216672	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atgaaagcgtgtgaccacctAcccacacaccttggcagagg	10	13	0	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:3216672A>C	ENST00000602557.1	-	22	3863		c.e22+1		CSMD1_ENST00000602723.1_Splice_Site|CSMD1_ENST00000539096.1_Splice_Site|CSMD1_ENST00000542608.1_Splice_Site|CSMD1_ENST00000537824.1_Splice_Site|CSMD1_ENST00000520002.1_Splice_Site|CSMD1_ENST00000400186.3_Splice_Site			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGACCACCTACCCACACACC	0.587													9	29					0	0	1	0	0	C	3216672	A	C	3216672	5	2	29	1	0	0	0	0	0	0	1	0	3969	405	14	4	7588	4	CSMD1	8	3216672	Splice_Site	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08		3216672	143147350	37	2765										
DDHD2	23259	broad.mit.edu	37	chr8	38095663	38095663	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gattggggttcaacacccacGgagcagggtcgaccaagaac	13	11	1	1	rs149994413	byFrequency	TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:38095663G>A	ENST00000397166.2	+	5	1083	c.558G>A	c.(556-558)acG>acA	p.T186T	DDHD2_ENST00000520272.2_Silent_p.T186T	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	186			T -> M (in dbSNP:rs2306899).		lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			CAACACCCACGGAGCAGGGTC	0.408													20	7					0	0	1	0	0	A	38095663	G	A	38095663	2	1	29	1	0	0	0	0	0	0	0	1	4350	1103	39	1		1	DDHD2	8	38095663	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	34878991	38095663	108268359	38	2766										
PCMTD1	115294	broad.mit.edu	37	chr8	52773451	52773451	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aaatatccggttccacttccCaggttaagaaaagacaatcc	6	11	0	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:52773451C>A	ENST00000360540.5	-	3	667	c.261G>T	c.(259-261)ctG>ctT	p.L87L	PCMTD1_ENST00000521344.1_Silent_p.L87L|PCMTD1_ENST00000544451.1_Intron|PCMTD1_ENST00000519559.1_Intron|PCMTD1_ENST00000522514.1_Silent_p.L87L	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	87						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				TTCCACTTCCCAGGTTAAGAA	0.333													28	84					4.74835e-14	5.48892e-14	1	1	0	A	52773451	C	A	52773451	2	1	29	1	0	0	0	0	0	0	0	1	11632	581	21	5		5	PCMTD1	8	52773451	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	14677788	52773451	93590571	39	2767										
ARMC1	55156	broad.mit.edu	37	chr8	66525567	66525567	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	attgagctttccttcgacgtGaattcatctcattaaaacta	5	9	2	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:66525567G>T	ENST00000276569.3	-	4	621	c.377C>A	c.(376-378)tCa>tAa	p.S126*	ARMC1_ENST00000458464.2_Intron	NM_018120.4	NP_060590.1	Q9NVT9	ARMC1_HUMAN	armadillo repeat containing 1	126					metal ion transport		metal ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(8)|skin(1)	14			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			CCTTCGACGTGAATTCATCTC	0.398													27	100					4.7796e-09	5.37705e-09	1	1	0	T	66525567	G	T	66525567	4	4	29	1	0	0	0	0	0	1	0	0	948	1294	45	2	487	2	ARMC1	8	66525567	Nonsense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	13752116	66525567	79838455	40	2768										
CPA6	57094	broad.mit.edu	37	chr8	68397009	68397009	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tctcatggctgggtcactctTatatgttagaagagcctaaa	9	8	3	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:68397009T>G	ENST00000297770.4	-	7	867	c.652A>C	c.(652-654)Aag>Cag	p.K218Q	CPA6_ENST00000518549.1_Missense_Mutation_p.K218Q|CPA6_ENST00000297769.4_Missense_Mutation_p.K70Q	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	218					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GGGTCACTCTTATATGTTAGA	0.353													7	87					0	0	1	0	0	G	68397009	T	G	68397009	3	3	29	1	0	0	0	0	1	0	0	0	3817	1763	61	4	681	4	CPA6	8	68397009	Missense_Mutation	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	1871442	68397009	77967013	41	2769										
SLC10A5	347051	broad.mit.edu	37	chr8	82606605	82606605	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ccaaaagcttgcgcctcaggCaatgccacaatctgagacaa	8	13	2	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:82606605C>G	ENST00000518568.1	-	1	1804	c.603G>C	c.(601-603)ttG>ttC	p.L201F		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	201						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						GCGCCTCAGGCAATGCCACAA	0.478													10	301					0	0	1	0	0	G	82606605	C	G	82606605	3	3	29	1	0	0	0	0	1	0	0	0	14431	709	25	5	715	5	SLC10A5	8	82606605	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	14209596	82606605	63757417	42	2770										
CCNE2	9134	broad.mit.edu	37	chr8	95900250	95900250	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	caacataaatctatcaaaaaAgtcttgtgcaagataaaatg	5	6	3	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:95900250A>T	ENST00000520509.1	-	7	757	c.505T>A	c.(505-507)Ttt>Att	p.F169I	CCNE2_ENST00000308108.4_Missense_Mutation_p.F169I|CCNE2_ENST00000523476.1_5'UTR|CCNE2_ENST00000396133.3_Missense_Mutation_p.F169I			O96020	CCNE2_HUMAN	cyclin E2	169					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					CTATCAAAAAAGTCTTGTGCA	0.294													58	21					0	0	1	0	0	T	95900250	A	T	95900250	3	4	29	1	0	0	0	0	1	0	0	0	2943	72	3	4	733	4	CCNE2	8	95900250	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	13293645	95900250	50463772	43	2771										
PTP4A3	11156	broad.mit.edu	37	chr8	142432356	142432356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gcgccatggctcggatgaacCgcccggccccggtggaggtg	17	14	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr8:142432356C>T	ENST00000520105.1	+	2	959	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	PTP4A3_ENST00000524028.1_Missense_Mutation_p.R6C|PTP4A3_ENST00000349124.1_Missense_Mutation_p.R6C|PTP4A3_ENST00000329397.1_Missense_Mutation_p.R6C|PTP4A3_ENST00000521578.1_Missense_Mutation_p.R6C			O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	6						early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(2)|large_intestine(1)|lung(3)	6	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			TCGGATGAACCGCCCGGCCCC	0.642													32	186					0	0	1	0	0	T	142432356	C	T	142432356	3	4	29	1	0	0	0	0	1	0	0	0	12821	652	23	1	18	1	PTP4A3	8	142432356	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	46532106	142432356	3931666	44	2772										
TRPM6	140803	broad.mit.edu	37	chr9	77415320	77415320	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ctccagttcctgagttcataCgtcaacagcgtcatggccat	8	13	3	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr9:77415320C>G	ENST00000451710.3	-	17	2325	c.2088G>C	c.(2086-2088)acG>acC	p.T696T	TRPM6_ENST00000361255.3_Silent_p.T691T|TRPM6_ENST00000360774.1_Silent_p.T696T|TRPM6_ENST00000449912.2_Silent_p.T691T|TRPM6_ENST00000376864.4_Silent_p.T696T|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	696					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGAGTTCATACGTCAACAGCG	0.512													12	34					0	0	1	0	0	G	77415320	C	G	77415320	2	3	29	1	0	0	0	0	0	0	0	1	16650	523	19	5		5	TRPM6	9	77415320	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		77415320	63798111	45	2773										
TRIM14	9830	broad.mit.edu	37	chr9	100862412	100862412	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atctgagttcagtgaatttcCccttcagccaggttttactt	7	10	3	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr9:100862412C>T	ENST00000341469.2	-	3	347	c.338G>A	c.(337-339)gGg>gAg	p.G113E	TRIM14_ENST00000342043.3_Missense_Mutation_p.G113E|TRIM14_ENST00000375098.3_Missense_Mutation_p.G113E	NM_014788.2	NP_055603.2	Q14142	TRI14_HUMAN	tripartite motif containing 14	113						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(62;0.0559)				AGTGAATTTCCCCTTCAGCCA	0.428													14	20					0	0	1	0	0	T	100862412	C	T	100862412	3	4	29	1	0	0	0	0	1	0	0	0	16549	623	22	3	1006	3	TRIM14	9	100862412	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	23447092	100862412	40351019	46	2774										
NR4A3	0	broad.mit.edu	37	chr9	102595040	102595040	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gcccagtagacaagagacgtCgaaaccgatgtcagtactgt	11	10	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr9:102595040C>T	ENST00000330847.1	+	3	1098	c.1054C>T	c.(1054-1056)Cga>Tga	p.R352*	NR4A3_ENST00000395097.2_Nonsense_Mutation_p.R341*|NR4A3_ENST00000338488.4_Nonsense_Mutation_p.R341*			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	341					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CAAGAGACGTCGAAACCGATG	0.368			T	EWSR1	extraskeletal myxoid chondrosarcoma								44	5					0	0	1	0	0	T	102595040	C	T	102595040	4	4	29	1	0	0	0	0	0	1	0	0	10681	876	31	1	1064	1	NR4A3	9	102595040	Nonsense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	1732628	102595040	38618391	47	2775										
SMC2	10592	broad.mit.edu	37	chr9	106874060	106874060	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gtcaaatgatggcctgtaaaAatgatataagtaaagctcag	9	5	2	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr9:106874060A>G	ENST00000286398.7	+	10	1507	c.1219A>G	c.(1219-1221)Aat>Gat	p.N407D	SMC2_ENST00000374793.3_Missense_Mutation_p.N407D|SMC2_ENST00000374787.3_Missense_Mutation_p.N407D|SMC2_ENST00000303219.8_Missense_Mutation_p.N407D	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	407					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						GGCCTGTAAAAATGATATAAG	0.418													25	1					0	0	1	0	0	G	106874060	A	G	106874060	3	3	29	1	0	0	0	0	1	0	0	0	14836	14	1	4	1253	4	SMC2	9	106874060	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	4279020	106874060	34339371	48	2776										
HSPA5	3309	broad.mit.edu	37	chr9	128003021	128003021	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cacgtgcggccgatgagccgCttggcgtcaaagaccgtgtt	14	12	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr9:128003021C>T	ENST00000324460.6	-	2	491	c.288G>A	c.(286-288)aaG>aaA	p.K96K		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	96					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	CGATGAGCCGCTTGGCGTCAA	0.567										Prostate(1;0.17)			34	63					0	0	1	0	0	T	128003021	C	T	128003021	2	4	29	1	0	0	0	0	0	0	0	1	7456	796	28	3		3	HSPA5	9	128003021	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	21128961	128003021	13210410	49	2777										
DNAJB12	54788	broad.mit.edu	37	chr10	74096299	74096299	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cactctgctgcttctccttcCagcagttgttccggaggttg	10	13	2	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr10:74096299C>T	ENST00000338820.3	-	7	1240	c.1091G>A	c.(1090-1092)tGg>tAg	p.W364*	DNAJB12_ENST00000444643.2_Nonsense_Mutation_p.W330*|DNAJB12_ENST00000461919.1_5'UTR|DNAJB12_ENST00000394903.2_Nonsense_Mutation_p.W364*	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	330					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						CTTCTCCTTCCAGCAGTTGTT	0.562													43	101					0	0	1	0	0	T	74096299	C	T	74096299	4	4	29	1	0	0	0	0	0	1	0	0	4644	595	21	3	146	3	DNAJB12	10	74096299	Nonsense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		74096299	61438448	50	2778										
KCNMA1	3778	broad.mit.edu	37	chr10	78709043	78709043	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	catcaccaggttccggaggcCgatcagggctgagctgacgt	14	12	2	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr10:78709043C>A	ENST00000286627.5	-	21	3344	c.2392G>T	c.(2392-2394)Ggc>Tgc	p.G798C	KCNMA1_ENST00000406533.3_Missense_Mutation_p.G860C|KCNMA1_ENST00000286628.8_Missense_Mutation_p.G856C|RP11-443A13.5_ENST00000458661.2_RNA|KCNMA1_ENST00000372443.1_Missense_Mutation_p.G798C|RP11-443A13.5_ENST00000598613.1_RNA|KCNMA1_ENST00000404771.3_Missense_Mutation_p.G856C|RP11-443A13.5_ENST00000426234.1_RNA|KCNMA1_ENST00000372440.1_Missense_Mutation_p.G798C|KCNMA1_ENST00000404857.1_Missense_Mutation_p.G839C|RP11-443A13.5_ENST00000600782.1_RNA|KCNMA1_ENST00000354353.5_Missense_Mutation_p.G859C	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	856					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TTCCGGAGGCCGATCAGGGCT	0.557													7	78					8.12818e-05	8.98378e-05	1	1	0	A	78709043	C	A	78709043	3	1	29	1	0	0	0	0	1	0	0	0	8116	652	23	5	1201	5	KCNMA1	10	78709043	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	4612744	78709043	56825704	51	2779										
SLC18A2	6571	broad.mit.edu	37	chr10	119027213	119027213	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gcaaaaaacatttatggactCatagctccgaactttggagt	8	8	1	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr10:119027213C>A	ENST00000298472.5	+	13	1295	c.1152C>A	c.(1150-1152)ctC>ctA	p.L384L	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	384					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TTTATGGACTCATAGCTCCGA	0.373													3	10					1	1	1	1	0	A	119027213	C	A	119027213	2	1	29	1	0	0	0	0	0	0	0	1	14480	813	29	2		2	SLC18A2	10	119027213	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	40318170	119027213	16507534	52	2780										
CDHR5	53841	broad.mit.edu	37	chr11	617618	617618	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gctgcggggggctcaggggcAccgcctggggaggcagggcc	22	12	1	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr11:617618A>G	ENST00000358353.3	-	16	2593	c.2271T>C	c.(2269-2271)ggT>ggC	p.G757G	CDHR5_ENST00000397542.2_Silent_p.G757G|CDHR5_ENST00000349570.7_Silent_p.G563G			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	757					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GCTCAGGGGCACCGCCTGGGG	0.776													3	18					0	0	1	0	0	G	617618	A	G	617618	2	3	29	1	0	0	0	0	0	0	0	1	3144	146	6	4		4	CDHR5	11	617618	Silent	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08		617618	134388898	53	2781										
OR4A47	403253	broad.mit.edu	37	chr11	48511046	48511046	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cagaaagggaggcaaaaagcCctctcaacctgcagttccca	9	13	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr11:48511046C>A	ENST00000446524.1	+	1	778	c.702C>A	c.(700-702)gcC>gcA	p.A234A		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						GGCAAAAAGCCCTCTCAACCT	0.433													12	166					0.000978159	0.0010534	1	1	0	A	48511046	C	A	48511046	2	1	29	1	0	0	0	0	0	0	0	1	11089	610	22	5		5	OR4A47	11	48511046	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	47893428	48511046	86495470	54	2782										
P2RX3	5024	broad.mit.edu	37	chr11	57114099	57114099	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gtaaccaaggtgaagggctcCggactctacgccaacagagt	12	11	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr11:57114099C>T	ENST00000263314.2	+	2	235	c.201C>T	c.(199-201)tcC>tcT	p.S67S		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	67					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						TGAAGGGCTCCGGACTCTACG	0.557													4	65					0	0	1	0	0	T	57114099	C	T	57114099	2	4	29	1	0	0	0	0	0	0	0	1	11387	639	23	1		1	P2RX3	11	57114099	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	8603053	57114099	77892417	55	2783										
FCHSD2	9873	broad.mit.edu	37	chr11	72552578	72552578	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gggctgctgggaggctggtcGtacaacggcagtggaggcag	20	8	0	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr11:72552578G>A	ENST00000409314.1	-	19	2217	c.2049C>T	c.(2047-2049)taC>taT	p.Y683Y	FCHSD2_ENST00000311172.7_Silent_p.Y603Y|ATG16L2_ENST00000534905.1_Intron|FCHSD2_ENST00000409418.4_Silent_p.Y659Y|FCHSD2_ENST00000409263.1_Silent_p.Y20Y|FCHSD2_ENST00000458644.2_Silent_p.Y523Y			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	659							protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			GAGGCTGGTCGTACAACGGCA	0.617													12	4					0	0	1	0	0	A	72552578	G	A	72552578	2	1	29	1	0	0	0	0	0	0	0	1	5822	1140	40	1		1	FCHSD2	11	72552578	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	15438479	72552578	62453938	56	2784										
RNF214	257160	broad.mit.edu	37	chr11	117152658	117152658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ccagtccctctctggctcctCggatgcccttctccattggg	9	17	2	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr11:117152658C>T	ENST00000530849.1	+	10	929	c.919C>T	c.(919-921)Cgg>Tgg	p.R307W	RNF214_ENST00000531287.1_Missense_Mutation_p.R307W|RNF214_ENST00000531452.1_Missense_Mutation_p.R462W|RNF214_ENST00000300650.4_Missense_Mutation_p.R462W|RNF214_ENST00000524917.1_Intron			Q8ND24	RN214_HUMAN	ring finger protein 214	462							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		TCTGGCTCCTCGGATGCCCTT	0.527													72	113					0	0	1	0	0	T	117152658	C	T	117152658	3	4	29	1	0	0	0	0	1	0	0	0	13529	875	31	1	1422	1	RNF214	11	117152658	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	44600080	117152658	17853858	57	2785										
RAPGEF3	10411	broad.mit.edu	37	chr12	48132985	48132985	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	agagcttggcgagggccagtCggtatacccggtggttccat	15	10	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr12:48132985C>T	ENST00000405493.2	-	24	2485	c.2276G>A	c.(2275-2277)cGa>cAa	p.R759Q	RAPGEF3_ENST00000449771.2_Missense_Mutation_p.R801Q|RAPGEF3_ENST00000548919.1_Missense_Mutation_p.R692Q|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.R801Q|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.R759Q|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.R759Q	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	759					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GAGGGCCAGTCGGTATACCCG	0.597													16	60					0	0	1	0	0	T	48132985	C	T	48132985	3	4	29	1	0	0	0	0	1	0	0	0	13096	884	31	1	389	1	RAPGEF3	12	48132985	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		48132985	85718910	58	2786										
GPR182	11318	broad.mit.edu	37	chr12	57389633	57389633	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	cttttgaaacgtacagcaccTgggccctggcggtggccctg	13	13	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr12:57389633T>C	ENST00000300098.1	+	2	859	c.640T>C	c.(640-642)Tgg>Cgg	p.W214R		NM_007264.3	NP_009195.1	O15218	GP182_HUMAN	G protein-coupled receptor 182	214						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	15						GTACAGCACCTGGGCCCTGGC	0.632													17	26					0	0	1	0	0	C	57389633	T	C	57389633	3	2	29	1	0	0	0	0	1	0	0	0	6716	1580	55	4	642	4	GPR182	12	57389633	Missense_Mutation	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	9256648	57389633	76462262	59	2787										
TBK1	29110	broad.mit.edu	37	chr12	64873902	64873902	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgtttcttgcagtctttctcGgtaagtatggtgtacctaat	9	7	3	0	rs56196591	byFrequency	TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr12:64873902G>A	ENST00000331710.5	+	7	1151	c.812_splice	c.e7+1	p.R271_splice		NM_013254.3	NP_037386.1	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	271	Protein kinase.		R -> Q (in dbSNP:rs56196591).		I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)	20				GBM - Glioblastoma multiforme(28;0.0386)		AGTCTTTCTCGGTAAGTATGG	0.398													14	36					0	0	1	0	0	A	64873902	G	A	64873902	5	1	29	1	0	0	0	0	0	0	1	0	15696	1130	39	1	834	1	TBK1	12	64873902	Splice_Site	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	7484269	64873902	68977993	60	2788										
USP30	84749	broad.mit.edu	37	chr12	109494590	109494590	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ttacagaaagaaagaagcgtAgaaaaggtaagaatgagaac	11	3	0	6			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr12:109494590A>C	ENST00000257548.5	+	2	280	c.187A>C	c.(187-189)Aga>Cga	p.R63R	USP30_ENST00000392784.2_Silent_p.R32R	NM_032663.3	NP_116052.2	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	63					ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(7)|kidney(1)|large_intestine(1)|liver(2)|lung(11)|prostate(1)|skin(3)|stomach(2)	28						AAAGAAGCGTAGAAAAGGTAA	0.423													16	55					0	0	1	0	0	C	109494590	A	C	109494590	2	2	29	1	0	0	0	0	0	0	0	1	17120	412	15	4		4	USP30	12	109494590	Silent	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	44620688	109494590	24357305	61	2789										
TMEM132B	114795	broad.mit.edu	37	chr12	126138685	126138685	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	taatcctagtgacctcacagTgacctcaagggggctaacgg	11	11	2	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr12:126138685T>C	ENST00000299308.3	+	9	2674	c.2666T>C	c.(2665-2667)gTg>gCg	p.V889A	TMEM132B_ENST00000535886.1_Missense_Mutation_p.V401A	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	889						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GACCTCACAGTGACCTCAAGG	0.507													8	92					0	0	1	0	0	C	126138685	T	C	126138685	3	2	29	1	0	0	0	0	1	0	0	0	16105	1696	59	4	2700	4	TMEM132B	12	126138685	Missense_Mutation	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	16644095	126138685	7713210	62	2790										
COG6	57511	broad.mit.edu	37	chr13	40297490	40297490	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atcgaagcacatttggacacActtataaatgagcaagcctc	7	10	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr13:40297490A>C	ENST00000416691.1	+	16	1705	c.1605A>C	c.(1603-1605)acA>acC	p.T535T	COG6_ENST00000455146.3_Silent_p.T535T	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	535					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		ATTTGGACACACTTATAAATG	0.368													14	17					0	0	1	0	0	C	40297490	A	C	40297490	2	2	29	1	0	0	0	0	0	0	0	1	3685	146	6	4		4	COG6	13	40297490	Silent	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08		40297490	74872388	63	2791										
STXBP6	0	broad.mit.edu	37	chr14	25325252	25325252	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgcatttttctgacgctgtgCtggctacccactggtcaaaa	9	11	2	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr14:25325252C>T	ENST00000323944.5	-	4	792	c.341G>A	c.(340-342)aGc>aAc	p.S114N	STXBP6_ENST00000546511.1_Missense_Mutation_p.S114N|STXBP6_ENST00000550887.1_Missense_Mutation_p.S114N|STXBP6_ENST00000548724.1_Missense_Mutation_p.S114N|STXBP6_ENST00000419632.2_Missense_Mutation_p.S114N|STXBP6_ENST00000358326.2_Missense_Mutation_p.S114N|STXBP6_ENST00000396700.1_Missense_Mutation_p.S114N			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	114					vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		TGACGCTGTGCTGGCTACCCA	0.423													4	57					0	0	1	0	0	T	25325252	C	T	25325252	3	4	29	1	0	0	0	0	1	0	0	0	15413	797	28	3	303	3	STXBP6	14	25325252	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		25325252	82024288	64	2792										
SAV1	60485	broad.mit.edu	37	chr14	51132202	51132202	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	catgaggtgttctttgaattGgagttctaaggaaactctgg	12	5	3	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr14:51132202G>C	ENST00000324679.4	-	2	593	c.230C>G	c.(229-231)cCa>cGa	p.P77R		NM_021818.3	NP_068590.1	Q9H4B6	SAV1_HUMAN	salvador homolog 1 (Drosophila)	77					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					TCTTTGAATTGGAGTTCTAAG	0.393													5	12					0	0	1	0	0	C	51132202	G	C	51132202	3	2	29	1	0	0	0	0	1	0	0	0	13908	1348	47	5	937	5	SAV1	14	51132202	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	25806950	51132202	56217338	65	2793										
MEIS2	4212	broad.mit.edu	37	chr15	37390250	37390250	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	catgacattggggtgcggggCgtgcgcgccgtagtgctgtg	19	9	0	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr15:37390250C>T	ENST00000338564.5	-	3	609	c.163G>A	c.(163-165)Gcc>Acc	p.A55T	MEIS2_ENST00000397620.2_5'UTR|MEIS2_ENST00000397624.3_5'UTR|MEIS2_ENST00000382766.2_Missense_Mutation_p.A55T|MEIS2_ENST00000340545.5_Missense_Mutation_p.A42T|MEIS2_ENST00000444725.1_Missense_Mutation_p.A55T|MEIS2_ENST00000424352.2_Missense_Mutation_p.A55T|MEIS2_ENST00000559561.1_Missense_Mutation_p.A55T|MEIS2_ENST00000561208.1_Missense_Mutation_p.A55T|MEIS2_ENST00000557796.2_Missense_Mutation_p.A42T|MEIS2_ENST00000559085.1_Missense_Mutation_p.A42T|MEIS2_ENST00000219869.9_5'UTR	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	55					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		GGGTGCGGGGCGTGCGCGCCG	0.667													36	7					0	0	1	0	0	T	37390250	C	T	37390250	3	4	29	1	0	0	0	0	1	0	0	0	9517	768	27	1	1377	1	MEIS2	15	37390250	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		37390250	65141142	66	2794										
USP50	373509	broad.mit.edu	37	chr15	50838720	50838720	+	Translation_Start_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gggagagacggctgagaagtCattttaatggaaccacgttg	14	6	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr15:50838720C>A	ENST00000532404.1	-	1	176	c.3G>T	c.(1-3)atG>atT	p.M1I	USP50_ENST00000530218.1_5'UTR	NM_203494.4	NP_987090.2	E9PP86	E9PP86_HUMAN	ubiquitin specific peptidase 50	1					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(5)	13				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		GCTGAGAAGTCATTTTAATGG	0.443													23	7					1.10513e-12	1.26588e-12	1	1	0	A	50838720	C	A	50838720	1	1	29	1	0	0	0	0	0	0	0	0	17141	826	29	2		2	USP50	15	50838720	Translation_Start_Site	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	13448470	50838720	51692672	67	2795										
RHCG	51458	broad.mit.edu	37	chr15	90026330	90026330	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aaggagaatgaactcattcaCagcgaagagggtcacttgga	12	7	3	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr15:90026330C>T	ENST00000268122.4	-	3	558	c.490G>A	c.(490-492)Gtg>Atg	p.V164M	RHCG_ENST00000544600.1_Missense_Mutation_p.V164M	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	164					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					AACTCATTCACAGCGAAGAGG	0.542													4	7					0	0	1	0	0	T	90026330	C	T	90026330	3	4	29	1	0	0	0	0	1	0	0	0	13375	478	17	3	981	3	RHCG	15	90026330	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	39187610	90026330	12505062	68	2796										
MMP25	64386	broad.mit.edu	37	chr16	3107185	3107185	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	taccgcctgtctcaggatgaCcgcgatggcctgcagcaact	11	14	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr16:3107185C>G	ENST00000336577.4	+	5	1050	c.813C>G	c.(811-813)gaC>gaG	p.D271E	RP11-473M20.7_ENST00000573878.1_RNA|RP11-473M20.7_ENST00000570949.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA|RP11-473M20.7_ENST00000573953.1_RNA|RP11-473M20.7_ENST00000572574.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	271					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						CTCAGGATGACCGCGATGGCC	0.642													16	225					0	0	1	0	0	G	3107185	C	G	3107185	3	3	29	1	0	0	0	0	1	0	0	0	9710	506	18	5	831	5	MMP25	16	3107185	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08		3107185	87247568	69	2797										
COQ7	10229	broad.mit.edu	37	chr16	19079036	19079036	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ccgcctttggcggctgcgccCgggggcccggcggtccctct	16	18	1	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr16:19079036C>T	ENST00000321998.5	+	1	116	c.50C>T	c.(49-51)cCg>cTg	p.P17L	COQ7_ENST00000568985.1_Missense_Mutation_p.P17L	NM_016138.4	NP_057222.2	Q99807	COQ7_HUMAN	coenzyme Q7 homolog, ubiquinone (yeast)	17					ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			breast(1)|large_intestine(1)|lung(3)|prostate(1)|skin(3)|urinary_tract(1)	10						cggctgcgcccgggggcccgg	0.627													9	44					0	0	1	0	0	T	19079036	C	T	19079036	3	4	29	1	0	0	0	0	1	0	0	0	3773	652	23	1	52	1	COQ7	16	19079036	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	15971851	19079036	71275717	70	2798										
SYT17	51760	broad.mit.edu	37	chr16	19195202	19195202	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	caggacatggcgcactccaaCccctacgtcaagatctgtct	8	15	3	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr16:19195202C>A	ENST00000562034.1	+	3	4299	c.501C>A	c.(499-501)aaC>aaA	p.N167K	SYT17_ENST00000355377.2_Missense_Mutation_p.N228K|SYT17_ENST00000568115.1_Missense_Mutation_p.N167K|SYT17_ENST00000562711.2_Missense_Mutation_p.N224K			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	228						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						CGCACTCCAACCCCTACGTCA	0.612													29	303					4.74835e-14	5.48892e-14	1	1	0	A	19195202	C	A	19195202	3	1	29	1	0	0	0	0	1	0	0	0	15529	506	18	5	702	5	SYT17	16	19195202	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	116166	19195202	71159551	71	2799										
RAP1GAP2	23108	broad.mit.edu	37	chr17	2911416	2911416	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	agtttgagaatggaggccacGgggggttcctggagtctttt	16	6	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr17:2911416G>A	ENST00000254695.8	+	17	1561	c.1471G>A	c.(1471-1473)Ggg>Agg	p.G491R	RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.G491R|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.G472R|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.G476R	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	491					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						TGGAGGCCACGGGGGGTTCCT	0.582													10	64					0	0	1	0	0	A	2911416	G	A	2911416	3	1	29	1	0	0	0	0	1	0	0	0	13089	1116	39	1	1537	1	RAP1GAP2	17	2911416	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08		2911416	78283794	72	2800										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q|TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			50	7					0	0	1	0	0	T	7577538	C	T	7577538	3	4	29	1	0	0	0	0	1	0	0	0	16441	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	4666122	7577538	73617672	73	2801										
DNAH9	1770	broad.mit.edu	37	chr17	11651054	11651054	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgatgagctctttggcatcaTcaatccagccacaggagaat	9	10	3	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr17:11651054T>A	ENST00000262442.3	+	32	6649	c.6581T>A	c.(6580-6582)aTc>aAc	p.I2194N	DNAH9_ENST00000454412.2_Missense_Mutation_p.I2194N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2194	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTTGGCATCATCAATCCAGCC	0.527													26	34					0	0	1	0	0	A	11651054	T	A	11651054	3	1	29	1	0	0	0	0	1	0	0	0	4635	1435	50	4	6707	4	DNAH9	17	11651054	Missense_Mutation	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	4073516	11651054	69544156	74	2802										
ZSWIM7	125150	broad.mit.edu	37	chr17	15884460	15884460	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tactggaacttccaaggaccTacaaagaaaggatagatggg	11	7	0	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr17:15884460T>A	ENST00000399277.1	-	4	299		c.e4-2		ZSWIM7_ENST00000486655.1_Intron|ZSWIM7_ENST00000472495.1_Splice_Site|ZSWIM7_ENST00000399280.2_Splice_Site	NM_001042697.1|NM_001042698.1	NP_001036162.1|NP_001036163.1	Q19AV6	ZSWM7_HUMAN	zinc finger, SWIM-type containing 7						DNA recombination|DNA repair	nucleus	zinc ion binding			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0827)		TCCAAGGACCTACAAAGAAAG	0.423													10	25					0	0	1	0	0	A	15884460	T	A	15884460	5	1	29	1	0	0	0	0	0	0	1	0	18284	1536	53	4	230	4	ZSWIM7	17	15884460	Splice_Site	SNP	T	TCGA-N8-A4PO-01A-11D-A28R-08	4233406	15884460	65310750	75	2803										
CHAD	1101	broad.mit.edu	37	chr17	48545806	48545806	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aggtagaggtaggtcagctcGgtcaggtcgtcgaaggcacc	16	9	2	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr17:48545806G>A	ENST00000508540.1	-	1	521	c.369C>T	c.(367-369)acC>acT	p.T123T	ACSF2_ENST00000506085.1_Intron|ACSF2_ENST00000502667.1_Intron|ACSF2_ENST00000504392.1_Intron|ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000427954.2_Intron|CHAD_ENST00000258969.4_Silent_p.T123T|ACSF2_ENST00000300441.4_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	123					regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AGGTCAGCTCGGTCAGGTCGT	0.602													7	147					0	0	1	0	0	A	48545806	G	A	48545806	2	1	29	1	0	0	0	0	0	0	0	1	3332	1103	39	1		1	CHAD	17	48545806	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	32661346	48545806	32649404	76	2804										
C17orf70	80233	broad.mit.edu	37	chr17	79514331	79514331	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ggacacggtcacgggcaggtCgagcccgccgttctcaccag	14	15	2	0			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr17:79514331C>T	ENST00000537152.1	-	5	1849	c.1324G>A	c.(1324-1326)Gac>Aac	p.D442N	C17orf70_ENST00000327787.8_Missense_Mutation_p.D593N|C17orf70_ENST00000425898.2_Missense_Mutation_p.D242N	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	593					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding	p.D442N(1)		breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			ACGGGCAGGTCGAGCCCGCCG	0.682													31	80					0	0	1	0	0	T	79514331	C	T	79514331	3	4	29	1	0	0	0	0	1	0	0	0	1886	884	31	1	888	1	C17orf70	17	79514331	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	30968525	79514331	1680879	77	2805										
DNM2	1785	broad.mit.edu	37	chr19	10906831	10906831	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	gtctgaaatgtgtcgacctgGttatccaggagctaatcaat	10	8	2	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:10906831G>C	ENST00000359692.6	+	10	1441	c.1291G>C	c.(1291-1293)Gtt>Ctt	p.V431L	DNM2_ENST00000389253.4_Intron|DNM2_ENST00000408974.4_Intron|DNM2_ENST00000585892.1_Missense_Mutation_p.V431L|DNM2_ENST00000355667.6_Missense_Mutation_p.V431L|DNM2_ENST00000314646.5_Intron	NM_004945.3	NP_004936.2	P50570	DYN2_HUMAN	dynamin 2	431					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TGTCGACCTGGTTATCCAGGA	0.532			"F, N, Splice, Mis, O"		ETP ALL								38	133					0	0	1	0	0	C	10906831	G	C	10906831	3	2	29	1	0	0	0	0	1	0	0	0	4699	1261	44	5	1329	5	DNM2	19	10906831	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08		10906831	48222152	78	2806										
DCAF15	90379	broad.mit.edu	37	chr19	14070448	14070448	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ggtgactgatcttcgtggccGcaacctgcggcccatgcggg	15	13	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:14070448G>A	ENST00000254337.6	+	8	1295	c.1274G>A	c.(1273-1275)cGc>cAc	p.R425H		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	425										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						CTTCGTGGCCGCAACCTGCGG	0.697											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	255					0	0	1	0	0	A	14070448	G	A	14070448	3	1	29	1	0	0	0	0	1	0	0	0	4291	1087	38	1	1304	1	DCAF15	19	14070448	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	3163617	14070448	45058535	79	2807										
JAK3	3718	broad.mit.edu	37	chr19	17943399	17943399	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ctttgaggatctgaatctccCgctgaaagtccctctgctgg	10	12	3	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:17943399C>T	ENST00000458235.1	-	19	2708	c.2609G>A	c.(2608-2610)cGg>cAg	p.R870Q	JAK3_ENST00000527670.1_Missense_Mutation_p.R870Q|JAK3_ENST00000534444.1_Missense_Mutation_p.R870Q	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	870	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						CTGAATCTCCCGCTGAAAGTC	0.577		2	Mis		"acute megakaryocytic leukemia, ETP ALL"								34	148					0	0	1	0	0	T	17943399	C	T	17943399	3	4	29	1	0	0	0	0	1	0	0	0	7982	652	23	1	789	1	JAK3	19	17943399	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	3872951	17943399	41185584	80	2808										
KIRREL2	84063	broad.mit.edu	37	chr19	36357197	36357197	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ctaccttctatgacttcaacCcacacctgggcatggtcccc	6	17	2	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:36357197C>G	ENST00000360202.5	+	15	2128	c.1930C>G	c.(1930-1932)Cca>Gca	p.P644A	KIRREL2_ENST00000262625.7_Intron|KIRREL2_ENST00000586102.2_Missense_Mutation_p.P624A|KIRREL2_ENST00000592409.1_Missense_Mutation_p.P609A|NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000347900.6_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	644	Pro-rich.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGACTTCAACCCACACCTGGG	0.622													6	141					0	0	1	0	0	G	36357197	C	G	36357197	3	3	29	1	0	0	0	0	1	0	0	0	8367	623	22	5	1988	5	KIRREL2	19	36357197	Missense_Mutation	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	18413798	36357197	22771786	81	2809										
CYP2F1	1572	broad.mit.edu	37	chr19	41622201	41622201	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ctgcctccgggacccagaccCctctcaatcctgggaaacct	8	18	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:41622201C>A	ENST00000331105.2	+	2	180	c.108C>A	c.(106-108)ccC>ccA	p.P36P		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	36					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						GACCCAGACCCCTCTCAATCC	0.547													100	247					1.21964e-59	1.44976e-59	1	1	0	A	41622201	C	A	41622201	2	1	29	1	0	0	0	0	0	0	0	1	4194	610	22	5		5	CYP2F1	19	41622201	Silent	SNP	C	TCGA-N8-A4PO-01A-11D-A28R-08	5265004	41622201	17506782	82	2810										
GPR4	2828	broad.mit.edu	37	chr19	46094975	46094975	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	atcaggtagacgcccagctcGttgcgctgttgcacctggcg	13	13	1	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:46094975G>A	ENST00000323040.4	-	2	1094	c.150C>T	c.(148-150)aaC>aaT	p.N50N	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	50						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		CGCCCAGCTCGTTGCGCTGTT	0.617													4	131					0	0	1	0	0	A	46094975	G	A	46094975	2	1	29	1	0	0	0	0	0	0	0	1	6733	1136	40	1		1	GPR4	19	46094975	Silent	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	4472774	46094975	13034008	83	2811										
KIR3DL1	3811	broad.mit.edu	37	chr19	55331426	55331426	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	tgttactcacaccccctatcAgttgtcagctcccagtgatc	6	15	3	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:55331426A>T	ENST00000391728.4	+	4	647	c.614A>T	c.(613-615)cAg>cTg	p.Q205L	KIR3DL1_ENST00000538269.1_Missense_Mutation_p.Q205L|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.Q205L|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.Q205L|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.Q110L|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.Q205L	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		ACCCCCTATCAGTTGTCAGCT	0.522													27	173					0	0	1	0	0	T	55331426	A	T	55331426	3	4	29	1	0	0	0	0	1	0	0	0	8362	188	7	4	628	4	KIR3DL1	19	55331426	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	9236451	55331426	3797557	84	2812										
ZNF470	388566	broad.mit.edu	37	chr19	57089133	57089133	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ctctgacagtacatcagagaAttcatacaggagagaaacct	8	9	3	3			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr19:57089133A>T	ENST00000330619.8	+	6	2022	c.1336A>T	c.(1336-1338)Att>Ttt	p.I446F	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.I446F	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ACATCAGAGAATTCATACAGG	0.418													5	109					0	0	1	0	0	T	57089133	A	T	57089133	3	4	29	1	0	0	0	0	1	0	0	0	17985	101	4	4	1350	4	ZNF470	19	57089133	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08	1757707	57089133	2039850	85	2813										
CDH26	60437	broad.mit.edu	37	chr20	58571629	58571629	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	aacagaacaagatcctcatgAaacctctgatatgggtgagc	9	9	2	5			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr20:58571629A>C	ENST00000350849.6	+	1	201	c.4A>C	c.(4-6)Aaa>Caa	p.K2Q	CDH26_ENST00000244049.3_Missense_Mutation_p.K2Q|CDH26_ENST00000348616.4_Intron|CDH26_ENST00000497614.1_Intron|CDH26_ENST00000244047.5_Intron	NM_021810.4	NP_068582.2	Q8IXH8	CAD26_HUMAN	cadherin 26	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GATCCTCATGAAACCTCTGAT	0.413													5	153					0	0	1	0	0	C	58571629	A	C	58571629	3	2	29	1	0	0	0	0	1	0	0	0	3132	247	9	4	1942	4	CDH26	20	58571629	Missense_Mutation	SNP	A	TCGA-N8-A4PO-01A-11D-A28R-08		58571629	4453891	86	2814										
BAGE2	85319	broad.mit.edu	37	chr21	11048496	11048497	+	RNA	DEL	AT	AT	-													0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	acctctccataaaaagtcacAtgttttatctcttcagctac					rs113591690		TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr21:11048496_11048497delAT	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAAAAGtcacatgttttatctc	0.396													3	3	---	---	---	---						-	11048497	AT	-	11048496	6	5	29	0	1	1	0	1	0	0	0	0	1290	232	8	0		0	BAGE2	21	11048496	RNA	DEL	AT	TCGA-N8-A4PO-01A-11D-A28R-08		11048496	37081399	87	2815										
PRDM15	63977	broad.mit.edu	37	chr21	43243763	43243763	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	ggtgtacttcttgtcgccgtGggtgagcaggtgcttgttca	15	8	2	1			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chr21:43243763G>A	ENST00000422911.1	-	15	1944	c.1843C>T	c.(1843-1845)Cac>Tac	p.H615Y	PRDM15_ENST00000538201.1_Missense_Mutation_p.H578Y|PRDM15_ENST00000398548.1_Missense_Mutation_p.H595Y|PRDM15_ENST00000269844.3_Missense_Mutation_p.H924Y|PRDM15_ENST00000447207.2_Missense_Mutation_p.H558Y			P57071	PRD15_HUMAN	PR domain containing 15	924					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TTGTCGCCGTGGGTGAGCAGG	0.607													4	8					0	0	1	0	0	A	43243763	G	A	43243763	3	1	29	1	0	0	0	0	1	0	0	0	12507	1348	47	3	1797	3	PRDM15	21	43243763	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08	32195267	43243763	4886132	88	2816										
OGT	8473	broad.mit.edu	37	chrX	70784520	70784520	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0112359550561798	1	1	0.161543715846995	0	0.209570225963669	1	1	0	taaccacccgttctcagtacGggttaccagaagatgccatc	8	13	1	2			TCGA-N8-A4PO-01A-11D-A28R-08	TCGA-N8-A4PO-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08a3c67f-02f0-4d96-a78c-1f543f6ecf55	6c6448a5-8344-4865-845b-0051c7d80041	g.chrX:70784520G>A	ENST00000373719.3	+	19	2723	c.2506G>A	c.(2506-2508)Ggg>Agg	p.G836R	OGT_ENST00000373701.3_Missense_Mutation_p.G826R	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	836					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					TTCTCAGTACGGGTTACCAGA	0.398													12	16					0	0	1	0	0	A	70784520	G	A	70784520	3	1	29	1	0	0	0	0	1	0	0	0	10894	1116	39	1	2580	1	OGT	23	70784520	Missense_Mutation	SNP	G	TCGA-N8-A4PO-01A-11D-A28R-08		70784520	84486040	89	2817										
CELA2B	51032	broad.mit.edu	37	chr1	15812530	15812530	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ctgggggtgatggcgtgataTgcacctgcaacgtgagtacc	15	9	0	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:15812530T>C	ENST00000375910.3	+	6	653	c.628T>C	c.(628-630)Tgc>Cgc	p.C210R		NM_015849.2	NP_056933.2	P08218	CEL2B_HUMAN	chymotrypsin-like elastase family, member 2B	210	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)	8						TGGCGTGATATGCACCTGCAA	0.562													55	173					0	0	1	0	0	C	15812530	T	C	15812530	3	2	30	1	0	0	0	0	1	0	0	0	3234	1464	51	4	650	4	CELA2B	1	15812530	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		15812530	233438091	1	2818										
CLCNKA	0	broad.mit.edu	37	chr1	16356552	16356552	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttaccaatcccatcatgcccGgggggtatgctctggcaggt	12	12	2	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:16356552G>A	ENST00000375692.1	+	15	1518	c.1390G>A	c.(1390-1392)Ggg>Agg	p.G464R	CLCNKA_ENST00000420078.1_Missense_Mutation_p.G464R|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000439316.2_Missense_Mutation_p.G421R|CLCNKA_ENST00000331433.4_Missense_Mutation_p.G464R			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	464					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity	p.Y466fs*25(1)		breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CATCATGCCCGGGGGGTATGC	0.657													4	38					0	0	1	0	0	A	16356552	G	A	16356552	3	1	30	1	0	0	0	0	1	0	0	0	3492	1116	39	1	1440	1	CLCNKA	1	16356552	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	544022	16356552	232894069	2	2819										
WNT4	54361	broad.mit.edu	37	chr1	22456324	22456324	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cctctgagatgctccccaccGacgacagcttggccaggtac	10	16	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:22456324G>A	ENST00000290167.6	-	2	141	c.98C>T	c.(97-99)tCg>tTg	p.S33L	WNT4_ENST00000542383.1_5'UTR	NM_030761.4	NP_110388.2	P56705	WNT4_HUMAN	wingless-type MMTV integration site family, member 4	33					adrenal gland development|androgen biosynthetic process|anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|dermatome development|endoderm development|epithelial to mesenchymal transition|establishment of protein localization in plasma membrane|female gonad development|female sex determination|liver development|male gonad development|mesonephric tubule development|metanephric mesenchymal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of male gonad development|negative regulation of testicular blood vessel morphogenesis|negative regulation of testosterone biosynthetic process|negative regulation of transcription, DNA-dependent|oocyte development|paramesonephric duct development|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of collagen biosynthetic process|positive regulation of cortisol biosynthetic process|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|protein palmitoylation|renal vesicle formation|smooth muscle cell differentiation|somatotropin secreting cell differentiation|tertiary branching involved in mammary gland duct morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|extracellular space|Golgi apparatus|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|signal transducer activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	8		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;9.02e-26)|Colorectal(126;1.71e-07)|COAD - Colon adenocarcinoma(152;1.17e-05)|GBM - Glioblastoma multiforme(114;2.01e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000568)|KIRC - Kidney renal clear cell carcinoma(1967;0.00277)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		GCTCCCCACCGACGACAGCTT	0.627													40	174					0	0	1	0	0	A	22456324	G	A	22456324	3	1	30	1	0	0	0	0	1	0	0	0	17449	1059	37	1	973	1	WNT4	1	22456324	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	6099772	22456324	226794297	3	2820										
PAQR7	164091	broad.mit.edu	37	chr1	26190027	26190027	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gaagaggggcagggcgtgtgGgtctccccagaagtccacgg	18	10	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:26190027G>T	ENST00000374296.3	-	2	970	c.304C>A	c.(304-306)Cca>Aca	p.P102T		NM_178422.5	NP_848509.1	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	102					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCGTGTGGGTCTCCCCAG	0.612													22	93					3.62473e-10	3.93072e-10	1	1	0	T	26190027	G	T	26190027	3	4	30	1	0	0	0	0	1	0	0	0	11486	1232	43	5	740	5	PAQR7	1	26190027	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	3733703	26190027	223060594	4	2821										
HIVEP3	59269	broad.mit.edu	37	chr1	42050036	42050036	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gatggaagcgtgggaaggaaGgagctggctctgaggatgga	20	4	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:42050036G>A	ENST00000372584.1	-	3	1447	c.433C>T	c.(433-435)Ctt>Ttt	p.L145F	HIVEP3_ENST00000429157.2_Missense_Mutation_p.L145F|HIVEP3_ENST00000372583.1_Missense_Mutation_p.L145F|HIVEP3_ENST00000247584.5_Missense_Mutation_p.L145F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	145					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGGAAGGAAGGAGCTGGCTC	0.612													40	177					0	0	1	0	0	A	42050036	G	A	42050036	3	1	30	1	0	0	0	0	1	0	0	0	7228	1000	35	3	6811	3	HIVEP3	1	42050036	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	15860009	42050036	207200585	5	2822										
EPS15	2060	broad.mit.edu	37	chr1	51868137	51868137	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aggatcagactggaaaaaatCcaagtttgtatctgcaactg	9	7	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:51868137C>A	ENST00000371733.3	-	18	1948	c.1852G>T	c.(1852-1854)Gat>Tat	p.D618Y	EPS15_ENST00000371730.2_Missense_Mutation_p.D484Y|EPS15_ENST00000396122.4_Missense_Mutation_p.D295Y	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	618	15 X 3 AA repeats of D-P-F.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(2)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						TGGAAAAAATCCAAGTTTGTA	0.269			T	MLL	ALL								22	88					7.16444e-05	7.52491e-05	1	1	0	A	51868137	C	A	51868137	3	1	30	1	0	0	0	0	1	0	0	0	5220	855	30	2	870	2	EPS15	1	51868137	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	9818101	51868137	197382484	6	2823										
C1orf87	127795	broad.mit.edu	37	chr1	60520989	60520989	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cacatcatctggattatcagTggtttgctgatcagtgaagt	10	7	4	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:60520989T>C	ENST00000371201.3	-	3	336	c.229A>G	c.(229-231)Act>Gct	p.T77A	C1orf87_ENST00000450089.2_Missense_Mutation_p.T77A	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	77							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GGATTATCAGTGGTTTGCTGA	0.423													46	136					0	0	1	0	0	C	60520989	T	C	60520989	3	2	30	1	0	0	0	0	1	0	0	0	2078	1696	59	4	1451	4	C1orf87	1	60520989	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	8652852	60520989	188729632	7	2824										
ADAM30	11085	broad.mit.edu	37	chr1	120438214	120438234	+	In_Frame_Del	DEL	TGTATCCTCATACGAACATCT	TGTATCCTCATACGAACATCT	-													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	atacttcaagagcctttaagTgtatcctcatacgaacatct							TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:120438214_120438234delTGTATCCTCATACGAACATCT	ENST00000369400.1	-	1	884_904	c.726_746delAGATGTTCGTATGAGGATACA	c.(724-747)cac>ca	p.QDVRMRIH242del		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	242	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AGCCTTTAAGTGTATCCTCATACGAACATCTTGAAAGTAGG	0.344													7	46	---	---	---	---						-	120438234	TGTATCCTCATACGAACATCT	-	120438214	7	5	30	1	0	1	0	1	0	0	0	0	247	1696	59	0	1630	0	ADAM30	1	120438214	In_Frame_Del	DEL	TGTATCCTCATACGAACATCT	TCGA-N8-A4PP-01A-11D-A28R-08	59917225	120438214	128812407	8	2825										
VPS72	6944	broad.mit.edu	37	chr1	151156886	151156886	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	acagtggggcccctttcgccGtcttgactggccctgcctct	11	16	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:151156886G>C	ENST00000354473.4	-	4	505	c.469C>G	c.(469-471)Cgg>Ggg	p.R157G	VPS72_ENST00000496809.1_5'UTR	NM_001271087.1|NM_005997.1	NP_001258016.1|NP_005988.1	Q15906	VPS72_HUMAN	vacuolar protein sorting 72 homolog (S. cerevisiae)	157					chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	14	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCTTTCGCCGTCTTGACTGG	0.557													19	338					0	0	1	0	0	C	151156886	G	C	151156886	3	2	30	1	0	0	0	0	1	0	0	0	17276	1144	40	5	637	5	VPS72	1	151156886	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	30718672	151156886	98093735	9	2826										
HRNR	388697	broad.mit.edu	37	chr1	152191669	152191669	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgcccaaaaccagaagcctgGcctgagccagactcataatg	9	13	1	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:152191669G>A	ENST00000368801.2	-	3	2511	c.2436C>T	c.(2434-2436)ggC>ggT	p.G812G	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	812					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAAGCCTGGCCTGAGCCAG	0.572													35	230					0	0	1	0	0	A	152191669	G	A	152191669	2	1	30	1	0	0	0	0	0	0	0	1	7399	1190	42	3		3	HRNR	1	152191669	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	1034783	152191669	97058952	10	2827										
KPRP	448834	broad.mit.edu	37	chr1	152733337	152733337	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cacgcccgcgtcctctaccaCgacaactttcagaaccttgt	6	17	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:152733337C>T	ENST00000368773.1	+	2	1331	c.1273C>T	c.(1273-1275)Cga>Tga	p.R425*	KPRP_ENST00000606109.1_Nonsense_Mutation_p.R425*	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	425	Pro-rich.					cytoplasm		p.R425*(1)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCTACCACGACAACTTTC	0.577													121	265					0	0	1	0	0	T	152733337	C	T	152733337	4	4	30	1	0	0	0	0	0	1	0	0	8478	528	19	1	1275	1	KPRP	1	152733337	Nonsense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	541668	152733337	96517284	11	2828										
LCE1A	353131	broad.mit.edu	37	chr1	152799971	152799971	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gtcctgccagcagagccagcAgcagtgccagccccctccca	10	19	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:152799971A>G	ENST00000335123.2	+	1	23	c.23A>G	c.(22-24)cAg>cGg	p.Q8R		NM_178348.2	NP_848125.1	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	8	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	8	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGAGCCAGCAGCAGTGCCAG	0.617													20	319					0	0	1	0	0	G	152799971	A	G	152799971	3	3	30	1	0	0	0	0	1	0	0	0	8697	188	7	4	25	4	LCE1A	1	152799971	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	66634	152799971	96450650	12	2829										
NPR1	4881	broad.mit.edu	37	chr1	153659705	153659705	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tttctacacaatggggctatCtgttcccatgggaacctcaa	8	11	3	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:153659705C>G	ENST00000368680.3	+	13	2437	c.1965C>G	c.(1963-1965)atC>atG	p.I655M		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	655	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	ATGGGGCTATCTGTTCCCATG	0.562													58	137					0	0	1	0	0	G	153659705	C	G	153659705	3	3	30	1	0	0	0	0	1	0	0	0	10641	903	32	2	2015	2	NPR1	1	153659705	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	859734	153659705	95590916	13	2830										
NPR1	4881	broad.mit.edu	37	chr1	153660533	153660533	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tacccccccaatacagagatCatcgagcgggtgactcgggg	12	13	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:153660533C>A	ENST00000368680.3	+	15	2725	c.2253C>A	c.(2251-2253)atC>atA	p.I751I		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	751	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	ATACAGAGATCATCGAGCGGG	0.657													62	108					3.07281e-33	3.6138e-33	1	1	0	A	153660533	C	A	153660533	2	1	30	1	0	0	0	0	0	0	0	1	10641	816	29	2		2	NPR1	1	153660533	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	828	153660533	95590088	14	2831										
OR10Z1	128368	broad.mit.edu	37	chr1	158576730	158576730	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tagttattttccacctctcaTtctgcagctcccatgaaatc	4	13	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:158576730T>G	ENST00000361284.1	+	1	502	c.502T>G	c.(502-504)Ttc>Gtc	p.F168V		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CCACCTCTCATTCTGCAGCTC	0.498													27	107					0	0	1	0	0	G	158576730	T	G	158576730	3	3	30	1	0	0	0	0	1	0	0	0	10970	1493	52	4	504	4	OR10Z1	1	158576730	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	4916197	158576730	90673891	15	2832										
GPR52	9293	broad.mit.edu	37	chr1	174417869	174417872	+	Frame_Shift_Del	DEL	TTGT	TTGT	-													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgcctattttactggctttaTtgtttgtttactttatgctc							TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:174417869_174417872delTTGT	ENST00000367685.2	+	1	658_661	c.620_623delTTGT	c.(619-624)atfs	p.IV207fs	RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000357444.6_Intron|RABGAP1L_ENST00000251507.4_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	207						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						ACTGGCTTTATTGTTTGTTTACTT	0.431													33	242	---	---	---	---						-	174417872	TTGT	-	174417869	7	5	30	1	0	1	0	1	0	0	0	0	6737	1493	52	0	622	0	GPR52	1	174417869	Frame_Shift_Del	DEL	TTGT	TCGA-N8-A4PP-01A-11D-A28R-08	15841139	174417869	74832752	16	2833										
ASTN1	460	broad.mit.edu	37	chr1	176915124	176915124	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gaatggttgttgtaaccaaaGaacatctccccaaagagggt	10	8	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:176915124G>T	ENST00000367654.2	-	13	2224	c.2211C>A	c.(2209-2211)ttC>ttA	p.F737L	ASTN1_ENST00000361833.2_Missense_Mutation_p.F729L|ASTN1_ENST00000367657.3_Missense_Mutation_p.F729L|ASTN1_ENST00000424564.2_Missense_Mutation_p.F729L|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	737					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TGTAACCAAAGAACATCTCCC	0.498													5	133					0.014758	0.0148469	1	1	0	T	176915124	G	T	176915124	3	4	30	1	0	0	0	0	1	0	0	0	1063	933	33	2	1745	2	ASTN1	1	176915124	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	2497255	176915124	72335497	17	2834										
FAM5B	0	broad.mit.edu	37	chr1	177199126	177199126	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttggctgtctcagccacggcGgctgctgtggtccccgagca	14	14	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:177199126G>A	ENST00000361539.4	+	2	426	c.114G>A	c.(112-114)gcG>gcA	p.A38A		NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		38						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CAGCCACGGCGGCTGCTGTGG	0.692													33	46					0	0	1	0	0	A	177199126	G	A	177199126	2	1	30	1	0	0	0	0	0	0	0	1	5627	1103	39	1		1	FAM5B	1	177199126	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	284002	177199126	72051495	18	2835										
DISP1	84976	broad.mit.edu	37	chr1	223116295	223116295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cccagcagctcacacccaaaGaagcaacaagaacaaaagtg	7	13	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr1:223116295G>C	ENST00000284476.6	+	2	294	c.130G>C	c.(130-132)Gaa>Caa	p.E44Q	DISP1_ENST00000495684.1_Intron|DISP1_ENST00000360254.2_Missense_Mutation_p.E44Q	NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	44					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		CACACCCAAAGAAGCAACAAG	0.507													15	57					0	0	1	0	0	C	223116295	G	C	223116295	3	2	30	1	0	0	0	0	1	0	0	0	4567	943	33	2	132	2	DISP1	1	223116295	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	45917169	223116295	26134326	19	2836										
MYT1L	23040	broad.mit.edu	37	chr2	1926933	1926933	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgccgaggtttaacaatgacTtggccaccagttcatcgtaa	9	10	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:1926933T>G	ENST00000399161.2	-	10	1355	c.608A>C	c.(607-609)aAg>aCg	p.K203T	MYT1L_ENST00000428368.2_Missense_Mutation_p.K203T	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	203					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TAACAATGACTTGGCCACCAG	0.423													4	33					0	0	1	0	0	G	1926933	T	G	1926933	3	3	30	1	0	0	0	0	1	0	0	0	10154	1609	56	4	3010	4	MYT1L	2	1926933	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		1926933	241272440	20	2837										
SPTBN1	0	broad.mit.edu	37	chr2	54858342	54858342	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gatgaagaccaccctgaaaaAccgagaggcctccctgggag	12	12	0	4			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:54858342A>C	ENST00000333896.5	+	15	3504	c.3119A>C	c.(3118-3120)aAc>aCc	p.N1040T	SPTBN1_ENST00000356805.4_Missense_Mutation_p.N1053T	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1053					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			ACCCTGAAAAACCGAGAGGCC	0.632													5	129					0	0	1	0	0	C	54858342	A	C	54858342	3	2	30	1	0	0	0	0	1	0	0	0	15174	43	2	4	3329	4	SPTBN1	2	54858342	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	52931409	54858342	188341031	21	2838										
ACTR3	10096	broad.mit.edu	37	chr2	114691916	114691916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	taggagaacggacgttgaccGgtacggtaatagacagtgga	15	6	0	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:114691916G>A	ENST00000263238.2	+	6	813	c.493G>A	c.(493-495)Ggt>Agt	p.G165S	ACTR3_ENST00000536059.1_Missense_Mutation_p.G103S|ACTR3_ENST00000535589.2_Missense_Mutation_p.G114S	NM_001277140.1|NM_005721.3	NP_001264069.1|NP_005712.1	P61158	ARP3_HUMAN	ARP3 actin-related protein 3 homolog (yeast)	165					cellular component movement|cilium morphogenesis	Arp2/3 protein complex	actin binding|ATP binding			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(2)	15						GACGTTGACCGGTACGGTAAT	0.418													86	117					0	0	1	0	0	A	114691916	G	A	114691916	3	1	30	1	0	0	0	0	1	0	0	0	212	1116	39	1	515	1	ACTR3	2	114691916	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	59833574	114691916	128507457	22	2839										
DPP10	57628	broad.mit.edu	37	chr2	116594298	116594298	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gcttgaaagaagaaaatataTtaataattcatggaactgct	7	4	1	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:116594298T>G	ENST00000410059.1	+	24	2638	c.2158T>G	c.(2158-2160)Tta>Gta	p.L720V	DPP10_ENST00000409163.1_Missense_Mutation_p.L670V|DPP10_ENST00000310323.8_Missense_Mutation_p.L713V|DPP10_ENST00000393147.2_Missense_Mutation_p.L724V	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	720					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AGAAAATATATTAATAATTCA	0.338													24	108					0	0	1	0	0	G	116594298	T	G	116594298	3	3	30	1	0	0	0	0	1	0	0	0	4753	1490	52	4	2423	4	DPP10	2	116594298	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	1902382	116594298	126605075	23	2840										
HOXD10	3236	broad.mit.edu	37	chr2	176982219	176982219	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tctcccaggtggagagccccGaggccaaaggcggccttccc	13	16	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:176982219G>A	ENST00000249501.4	+	1	913	c.658G>A	c.(658-660)Gag>Aag	p.E220K	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	220						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GGAGAGCCCCGAGGCCAAAGG	0.622													13	67					0	0	1	0	0	A	176982219	G	A	176982219	3	1	30	1	0	0	0	0	1	0	0	0	7359	1059	37	1	660	1	HOXD10	2	176982219	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	60387921	176982219	66217154	24	2841										
HOXD9	3235	broad.mit.edu	37	chr2	176987826	176987826	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cccctggccgcctctgcctcCgagcccggccgctacgtgcg	12	21	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:176987826C>T	ENST00000249499.6	+	1	739	c.330C>T	c.(328-330)tcC>tcT	p.S110S	HOXD-AS2_ENST00000440016.2_RNA	NM_014213.3	NP_055028.3	P28356	HXD9_HUMAN	homeobox D9	110						nucleus	sequence-specific DNA binding			endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CCTCTGCCTCCGAGCCCGGCC	0.796													6	10					0	0	1	0	0	T	176987826	C	T	176987826	2	4	30	1	0	0	0	0	0	0	0	1	7366	639	23	1		1	HOXD9	2	176987826	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	5607	176987826	66211547	25	2842										
TTN	7273	broad.mit.edu	37	chr2	179615491	179615491	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gtgtaccaaaagattcgctgGcatgtggtgtaatagcttga	12	6	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:179615491G>T	ENST00000360870.5	-	46	11858	c.11636C>A	c.(11635-11637)gCc>gAc	p.A3879D	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9701							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTCGCTGGCATGTGGTGT	0.358													13	40					9.31168e-06	9.90478e-06	1	1	0	T	179615491	G	T	179615491	3	4	30	1	0	0	0	0	1	0	0	0	16796	1203	42	5	98661	5	TTN	2	179615491	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	2627665	179615491	63583882	26	2843										
STAT1	6772	broad.mit.edu	37	chr2	191848434	191848434	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ccgctcgggagctggctgacGttggagatcaccacaacggg	15	12	1	2	rs150942324		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:191848434G>C	ENST00000361099.3	-	17	1767	c.1380C>G	c.(1378-1380)aaC>aaG	p.N460K	STAT1_ENST00000392322.3_Missense_Mutation_p.N460K|STAT1_ENST00000392323.2_Missense_Mutation_p.N462K|STAT1_ENST00000409465.1_Missense_Mutation_p.N460K|STAT1_ENST00000540176.1_3'UTR	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	460					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GCTGGCTGACGTTGGAGATCA	0.507													21	122					0	0	1	0	0	C	191848434	G	C	191848434	3	2	30	1	0	0	0	0	1	0	0	0	15319	1136	40	5	912	5	STAT1	2	191848434	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	12232943	191848434	51350939	27	2844										
TRIP12	9320	broad.mit.edu	37	chr2	230667108	230667108	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	atggatcccgatccattcgtAcatgcctttggtggacttgt	10	10	0	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:230667108A>G	ENST00000283943.5	-	20	3019	c.2841T>C	c.(2839-2841)tgT>tgC	p.C947C	TRIP12_ENST00000543084.1_Intron|TRIP12_ENST00000389045.3_Silent_p.C677C|TRIP12_ENST00000389044.4_Silent_p.C995C	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	947					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		ATCCATTCGTACATGCCTTTG	0.473													10	89					0	0	1	0	0	G	230667108	A	G	230667108	2	3	30	1	0	0	0	0	0	0	0	1	16616	389	14	4		4	TRIP12	2	230667108	Silent	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	38818674	230667108	12532265	28	2845										
UGT1A4	0	broad.mit.edu	37	chr2	234628129	234628129	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ctctaccctctggccctgtcCtacatttgccatactttttc	4	16	2	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr2:234628129C>A	ENST00000373409.3	+	1	706	c.663C>A	c.(661-663)tcC>tcA	p.S221S	UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		TGGCCCTGTCCTACATTTGCC	0.463													28	183					2.48779e-11	2.71544e-11	1	1	0	A	234628129	C	A	234628129	2	1	30	1	0	0	0	0	0	0	0	1	17006	668	24	5		5	UGT1A4	2	234628129	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	3961021	234628129	8571244	29	2846										
BRPF1	7862	broad.mit.edu	37	chr3	9786709	9786709	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aagacttaccagccaatggcTtcagcggtggaaaccaacca	9	12	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr3:9786709T>G	ENST00000383829.2	+	10	3342	c.2938T>G	c.(2938-2940)Ttc>Gtc	p.F980V	BRPF1_ENST00000457855.1_Missense_Mutation_p.F974V|BRPF1_ENST00000433861.2_Missense_Mutation_p.F879V|BRPF1_ENST00000302054.3_Missense_Mutation_p.F974V|BRPF1_ENST00000424362.1_Missense_Mutation_p.F973V	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	974	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					AGCCAATGGCTTCAGCGGTGG	0.527													24	76					0	0	1	0	0	G	9786709	T	G	9786709	3	3	30	1	0	0	0	0	1	0	0	0	1522	1609	56	4	2972	4	BRPF1	3	9786709	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		9786709	188235721	30	2847										
TRANK1	9881	broad.mit.edu	37	chr3	36874297	36874297	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttgcaaaggccatacatatcTgtagacaaaatataatcaat	5	7	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr3:36874297T>G	ENST00000429976.2	-	21	6892	c.6645A>C	c.(6643-6645)acA>acC	p.T2215T	TRANK1_ENST00000428977.2_Silent_p.T1665T|TRANK1_ENST00000301807.6_Silent_p.T1665T			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2215					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CATACATATCTGTAGACAAAA	0.388													19	52					0	0	1	0	0	G	36874297	T	G	36874297	2	3	30	1	0	0	0	0	0	0	0	1	16514	1567	55	4		4	TRANK1	3	36874297	Silent	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	27087588	36874297	161148133	31	2848										
DRD3	1814	broad.mit.edu	37	chr3	113850128	113850128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggactcagggaattccgagtCttctcctctcttttcaactc	7	13	5	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr3:113850128C>G	ENST00000383673.2	-	6	1273	c.843G>C	c.(841-843)aaG>aaC	p.K281N	DRD3_ENST00000460779.1_Missense_Mutation_p.K281N|DRD3_ENST00000467632.1_Missense_Mutation_p.K281N|DRD3_ENST00000295881.7_Missense_Mutation_p.K281N	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	281					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AATTCCGAGTCTTCTCCTCTC	0.522													82	164					0	0	1	0	0	G	113850128	C	G	113850128	3	3	30	1	0	0	0	0	1	0	0	0	4784	912	32	2	367	2	DRD3	3	113850128	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	76975831	113850128	84172302	32	2849										
ATP11B	23200	broad.mit.edu	37	chr3	182584220	182584220	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gatgaaaaggctctagtagaAgctgctgcaaggtaatttag	12	5	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr3:182584220A>G	ENST00000323116.5	+	14	1868	c.1608A>G	c.(1606-1608)gaA>gaG	p.E536E		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	536					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			CTCTAGTAGAAGCTGCTGCAA	0.378													33	77					0	0	1	0	0	G	182584220	A	G	182584220	2	3	30	1	0	0	0	0	0	0	0	1	1119	69	3	4		4	ATP11B	3	182584220	Silent	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	68734092	182584220	15438210	33	2850										
ATP13A4	84239	broad.mit.edu	37	chr3	193188757	193188757	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aaatctccaggcaccaggacGcgtgattccagctcttgaac	9	13	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr3:193188757G>A	ENST00000342695.4	-	9	1156	c.834C>T	c.(832-834)cgC>cgT	p.R278R	ATP13A4_ENST00000392443.3_Silent_p.R278R|ATP13A4_ENST00000295548.3_Silent_p.R278R	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	278					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GCACCAGGACGCGTGATTCCA	0.448													50	253					0	0	1	0	0	A	193188757	G	A	193188757	2	1	30	1	0	0	0	0	0	0	0	1	1125	1074	38	1		1	ATP13A4	3	193188757	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	10604537	193188757	4833673	34	2851										
GNRHR	0	broad.mit.edu	37	chr4	68619733	68619733	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cagagtaactctccagcataCcattggactgtaatgttcca	7	11	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr4:68619733C>G	ENST00000226413.4	-	1	345	c.321G>C	c.(319-321)tgG>tgC	p.W107C	GNRHR_ENST00000420975.2_Missense_Mutation_p.W107C|RP11-453E17.1_ENST00000500538.2_RNA|RP11-453E17.1_ENST00000502758.1_RNA	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	107					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	CTCCAGCATACCATTGGACTG	0.473													15	61					0	0	1	0	0	G	68619733	C	G	68619733	3	3	30	1	0	0	0	0	1	0	0	0	6590	508	18	5	677	5	GNRHR	4	68619733	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08		68619733	122534543	35	2852										
HNRNPD	3184	broad.mit.edu	37	chr4	83279884	83279884	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gaaaggccaccaacaaaaatTtttttaaccggctcttttgt	6	9	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr4:83279884T>A	ENST00000313899.7	-	4	826	c.549A>T	c.(547-549)aaA>aaT	p.K183N	HNRNPD_ENST00000353341.4_Missense_Mutation_p.K183N|HNRNPD_ENST00000541060.1_Missense_Mutation_p.K29N|HNRNPD_ENST00000543098.1_Missense_Mutation_p.K131N|HNRNPD_ENST00000352301.4_Missense_Mutation_p.K164N	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	183	RRM 2.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						CAACAAAAATTTTTTTAACCG	0.368													19	70					0	0	1	0	0	A	83279884	T	A	83279884	3	1	30	1	0	0	0	0	1	0	0	0	7304	1838	64	4	538	4	HNRNPD	4	83279884	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	14660151	83279884	107874392	36	2853										
ENPP6	133121	broad.mit.edu	37	chr4	185074851	185074851	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggtggtggggtcccacatgtAgttcccgatcatctgatgga	14	9	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr4:185074851A>C	ENST00000296741.2	-	2	418	c.277T>G	c.(277-279)Tac>Gac	p.Y93D		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	93					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TCCCACATGTAGTTCCCGATC	0.473													10	35					0	0	1	0	0	C	185074851	A	C	185074851	3	2	30	1	0	0	0	0	1	0	0	0	5162	420	15	4	1073	4	ENPP6	4	185074851	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	101794967	185074851	6079425	37	2854										
FASTKD3	79072	broad.mit.edu	37	chr5	7863053	7863053	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	agaatccacaggggtctccaGggaacagcatggggtaagaa	14	8	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:7863053G>C	ENST00000264669.5	-	4	1718	c.1582C>G	c.(1582-1584)Ctg>Gtg	p.L528V	FASTKD3_ENST00000513658.1_5'UTR|MTRR_ENST00000502509.1_Intron	NM_024091.3	NP_076996.2	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	528					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGGGTCTCCAGGGAACAGCAT	0.378													71	167					0	0	1	0	0	C	7863053	G	C	7863053	3	2	30	1	0	0	0	0	1	0	0	0	5719	991	35	5	422	5	FASTKD3	5	7863053	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		7863053	173052207	38	2855										
ZNF622	90441	broad.mit.edu	37	chr5	16463618	16463618	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tttaatcagtcccttaatatCtgaaagatattctatatcag	4	7	4	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:16463618C>G	ENST00000308683.2	-	2	985	c.859G>C	c.(859-861)Gat>Cat	p.D287H		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	287						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CCCTTAATATCTGAAAGATAT	0.368													15	84					0	0	1	0	0	G	16463618	C	G	16463618	3	3	30	1	0	0	0	0	1	0	0	0	18102	913	32	2	594	2	ZNF622	5	16463618	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	8600565	16463618	164451642	39	2856										
NDUFAF2	91942	broad.mit.edu	37	chr5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttacccctactgcgggtcccGctgctggcagcgctggaaac	12	15	0	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632													3	23					0	0	1	0	0	A	60241050	G	A	60241050	1	1	30	1	0	0	0	0	0	0	0	0	10321	1102	38	1		1	NDUFAF2	5	60241050	Translation_Start_Site	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	43777432	60241050	120674210	40	2857										
RASA1	5921	broad.mit.edu	37	chr5	86668014	86668014	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	caataaacgccttcgtcaggTgaagcttaattttcttggat	8	8	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:86668014T>C	ENST00000456692.2	+	13	1360		c.e13+2		RASA1_ENST00000506290.1_Splice_Site|RASA1_ENST00000512763.1_Splice_Site|RASA1_ENST00000274376.6_Splice_Site	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1						cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CTTCGTCAGGTGAAGCTTAAT	0.363													10	17					0	0	1	0	0	C	86668014	T	C	86668014	5	2	30	1	0	0	0	0	0	0	1	0	13111	1710	59	4	1840	4	RASA1	5	86668014	Splice_Site	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	26426964	86668014	94247246	41	2858										
PJA2	9867	broad.mit.edu	37	chr5	108680479	108680479	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ctagctggtggattggccacCtcaacatccactgcaagaga	10	12	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:108680479C>G	ENST00000361189.2	-	8	2045	c.1806G>C	c.(1804-1806)gaG>gaC	p.E602D	PJA2_ENST00000361557.3_Missense_Mutation_p.E602D	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	602	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		GATTGGCCACCTCAACATCCA	0.408													9	87					0	0	1	0	0	G	108680479	C	G	108680479	3	3	30	1	0	0	0	0	1	0	0	0	12009	680	24	5	332	5	PJA2	5	108680479	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	22012465	108680479	72234781	42	2859										
PPIC	5480	broad.mit.edu	37	chr5	122365082	122365082	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	caatcacaattctgccaacaTctttgtctccaatcctcaca	2	15	5	0	rs45449493		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:122365082T>C	ENST00000306442.4	-	2	264	c.149A>G	c.(148-150)gAt>gGt	p.D50G		NM_000943.4	NP_000934.1	P45877	PPIC_HUMAN	peptidylprolyl isomerase C (cyclophilin C)	50	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	6		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	TCTGCCAACATCTTTGTCTCC	0.398													10	69					0	0	1	0	0	C	122365082	T	C	122365082	3	2	30	1	0	0	0	0	1	0	0	0	12368	1435	50	4	505	4	PPIC	5	122365082	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	13684603	122365082	58550178	43	2860										
PCDHA9	0	broad.mit.edu	37	chr5	140229832	140229832	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	agcgagatggtgctgcggtcGgtgggcgccggcgtagtggt	21	8	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:140229832G>A	ENST00000378122.3	+	1	2476	c.1752G>A	c.(1750-1752)tcG>tcA	p.S584S	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Silent_p.S584S|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGCGGTCGGTGGGCGCCG	0.667													58	130					0	0	1	0	0	A	140229832	G	A	140229832	2	1	30	1	0	0	0	0	0	0	0	1	11577	1103	39	1		1	PCDHA9	5	140229832	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	17864750	140229832	40685428	44	2861										
PDGFRB	5159	broad.mit.edu	37	chr5	149503887	149503887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gactcatgatcttcagctccGacataagggcttgcttctca	8	12	4	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:149503887G>A	ENST00000261799.4	-	14	2418	c.1949C>T	c.(1948-1950)tCg>tTg	p.S650L		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	650	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTTCAGCTCCGACATAAGGGC	0.637			T	"ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"	"MPD, AML, CMML, CML"								18	59					0	0	1	0	0	A	149503887	G	A	149503887	3	1	30	1	0	0	0	0	1	0	0	0	11708	1059	37	1	1411	1	PDGFRB	5	149503887	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	9274055	149503887	31411373	45	2862										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171849420	171849420	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cagagacctcaaatccttacCtggaggtcaaaaaacttgct	7	11	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr5:171849420C>T	ENST00000311601.5	-	2	326	c.156_splice	c.e2+1	p.Q52_splice	SH3PXD2B_ENST00000519643.1_Splice_Site_p.Q52_splice	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	52	PX.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AAATCCTTACCTGGAGGTCAA	0.498													4	15					0	0	1	0	0	T	171849420	C	T	171849420	5	4	30	1	0	0	0	0	0	0	1	0	14311	695	24	3	2627	3	SH3PXD2B	5	171849420	Splice_Site	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	22345533	171849420	9065840	46	2863										
NRN1	51299	broad.mit.edu	37	chr6	6002646	6002646	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gcgggtagttggccatgctgTcgcccagcttgagcaaacag	14	11	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr6:6002646T>C	ENST00000244766.2	-	2	357	c.140A>G	c.(139-141)gAc>gGc	p.D47G	NRN1_ENST00000495850.1_5'UTR	NM_016588.2	NP_057672.1	Q9NPD7	NRN1_HUMAN	neuritin 1	47						anchored to membrane|plasma membrane				endometrium(2)|large_intestine(2)|lung(4)	8	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		GGCCATGCTGTCGCCCAGCTT	0.612													33	146					0	0	1	0	0	C	6002646	T	C	6002646	3	2	30	1	0	0	0	0	1	0	0	0	10705	1667	58	4	296	4	NRN1	6	6002646	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		6002646	165112421	47	2864										
TDRD6	221400	broad.mit.edu	37	chr6	46660414	46660415	+	Frame_Shift_Ins	INS	-	-	A													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tcttaactggtataatccagINSaaaaaaaaatgataagagct					rs145334816		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr6:46660414_46660415insA	ENST00000544460.1	+	1	4803_4804	c.4549_4550insA	c.(4549-4551)aaafs	p.K1517fs	TDRD6_ENST00000316081.6_Frame_Shift_Ins_p.K1517fs	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1517					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GTATAATCCAGAAAAAAAAATG	0.351													7	73	---	---	---	---						A	46660415	-	A	46660414	7	5	30	1	0	1	1	0	0	0	0	0	15792	943	33	0	4551	0	TDRD6	6	46660414	Frame_Shift_Ins	INS	-	TCGA-N8-A4PP-01A-11D-A28R-08	40657768	46660414	124454653	48	2865										
RRAGD	58528	broad.mit.edu	37	chr6	90121645	90121647	+	In_Frame_Del	DEL	TCC	TCC	-													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ccgctagccccaccagctcaTcctcctcctcctcctcctcc							TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr6:90121645_90121647delTCC	ENST00000369415.4	-	1	342_344	c.66_68delGGA	c.(64-69)gat>ga	p.ED22del	RRAGD_ENST00000359203.2_5'UTR	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	22					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CACCAGctcatcctcctcctcct	0.754													3	4	---	---	---	---						-	90121647	TCC	-	90121645	7	5	30	1	0	1	0	1	0	0	0	0	13726	1435	50	0	1162	0	RRAGD	6	90121645	In_Frame_Del	DEL	TCC	TCGA-N8-A4PP-01A-11D-A28R-08	43461231	90121645	80993422	49	2866										
EPB41L2	2037	broad.mit.edu	37	chr6	131199330	131199330	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgtggattccataaaattgcGcttgagttcactaatgctag	9	7	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr6:131199330G>A	ENST00000337057.3	-	14	2138	c.1957C>T	c.(1957-1959)Cgc>Tgc	p.R653C	EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000530757.1_Missense_Mutation_p.R52C|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000368128.2_Missense_Mutation_p.R653C|EPB41L2_ENST00000530481.1_Intron|EPB41L2_ENST00000527411.1_Intron|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000529208.1_Intron|EPB41L2_ENST00000524581.1_Missense_Mutation_p.R31C|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000527659.1_Intron	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	653	Spectrin--actin-binding.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		ATAAAATTGCGCTTGAGTTCA	0.458													20	28					0	0	1	0	0	A	131199330	G	A	131199330	3	1	30	1	0	0	0	0	1	0	0	0	5181	1087	38	1	1084	1	EPB41L2	6	131199330	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	41077685	131199330	39915737	50	2867										
RAET1E	135250	broad.mit.edu	37	chr6	150210552	150210552	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	agtgatcgcagtctccctttGagagcttcctgaaatacttt	8	10	1	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr6:150210552G>T	ENST00000532335.1	-	4	900	c.554C>A	c.(553-555)tCa>tAa	p.S185*	RAET1E_ENST00000367363.3_Nonsense_Mutation_p.S149*|RAET1E_ENST00000357183.4_Nonsense_Mutation_p.S185*|RAET1E_ENST00000529948.1_Nonsense_Mutation_p.S185*|RP11-244K5.1_ENST00000605899.1_RNA|RP11-244K5.8_ENST00000606915.1_RNA	NM_001243328.1	NP_001230257.1	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E	185	MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding			cervix(1)|kidney(2)|large_intestine(3)|lung(3)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		GTCTCCCTTTGAGAGCTTCCT	0.493													43	45					1.8453e-21	2.12527e-21	1	1	0	T	150210552	G	T	150210552	4	4	30	1	0	0	0	0	0	1	0	0	13050	1294	45	2	245	2	RAET1E	6	150210552	Nonsense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	19011222	150210552	20904515	51	2868										
GET4	51608	broad.mit.edu	37	chr7	933563	933563	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	accgcataggacagctgttcTtcggcgtcccgcccaagcag	11	15	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:933563T>G	ENST00000407192.1	+	7	3208	c.691T>G	c.(691-693)Ttc>Gtc	p.F231V	GET4_ENST00000265857.3_Missense_Mutation_p.F284V			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	284					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						ACAGCTGTTCTTCGGCGTCCC	0.692													12	34					0	0	1	0	0	G	933563	T	G	933563	3	3	30	1	0	0	0	0	1	0	0	0	6377	1609	56	4	880	4	GET4	7	933563	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		933563	158205100	52	2869										
MIOS	54468	broad.mit.edu	37	chr7	7625282	7625282	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgcaggagatctgaatctcaAtgtggtagcaatggctttat	11	6	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:7625282A>G	ENST00000340080.4	+	7	2085	c.1664A>G	c.(1663-1665)aAt>aGt	p.N555S	MIOS_ENST00000405785.1_Missense_Mutation_p.N555S	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	555										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTGAATCTCAATGTGGTAGCA	0.368													53	66					0	0	1	0	0	G	7625282	A	G	7625282	3	3	30	1	0	0	0	0	1	0	0	0	9636	101	4	4	1678	4	MIOS	7	7625282	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	6691719	7625282	151513381	53	2870										
AMPH	273	broad.mit.edu	37	chr7	38431442	38431442	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gctggtgcagaaggcgtgggCtgagggtcctggataggctt	19	7	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:38431442C>T	ENST00000356264.2	-	19	2000	c.1785G>A	c.(1783-1785)caG>caA	p.Q595Q	AMPH_ENST00000428293.2_Silent_p.Q553Q|AMPH_ENST00000325590.5_Silent_p.Q553Q	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	595					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						AAGGCGTGGGCTGAGGGTCCT	0.632													20	74					0	0	1	0	0	T	38431442	C	T	38431442	2	4	30	1	0	0	0	0	0	0	0	1	584	796	28	3		3	AMPH	7	38431442	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	30806160	38431442	120707221	54	2871										
ABCA13	154664	broad.mit.edu	37	chr7	48319344	48319344	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tttcagccactttttgagatTttcattaaagcaaccaccgg	6	10	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:48319344T>C	ENST00000435803.1	+	18	8577	c.8553T>C	c.(8551-8553)atT>atC	p.I2851I		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2851					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTTTTGAGATTTTCATTAAAG	0.348													24	94					0	0	1	0	0	C	48319344	T	C	48319344	2	2	30	1	0	0	0	0	0	0	0	1	31	1829	64	4		4	ABCA13	7	48319344	Silent	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	9887902	48319344	110819319	55	2872										
CACNA2D1	781	broad.mit.edu	37	chr7	81591249	81591249	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ctaatacaccactgaatgatTtactgtcgttatcgaagaaa	6	8	0	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:81591249T>C	ENST00000356860.3	-	36	3265	c.2927A>G	c.(2926-2928)aAa>aGa	p.K976R	CACNA2D1_ENST00000535308.1_Missense_Mutation_p.K188R|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.K988R	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	988						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ACTGAATGATTTACTGTCGTT	0.388													4	65					0	0	1	0	0	C	81591249	T	C	81591249	3	2	30	1	0	0	0	0	1	0	0	0	2566	1841	64	4	364	4	CACNA2D1	7	81591249	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	33271905	81591249	77547414	56	2873										
PCLO	27445	broad.mit.edu	37	chr7	82784272	82784272	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gctgcagaggttttccagatCctgtttggcttactggtttt	11	8	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:82784272C>G	ENST00000423517.2	-	2	2022	c.1685G>C	c.(1684-1686)gGa>gCa	p.G562A	PCLO_ENST00000333891.8_Missense_Mutation_p.G562A	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	508	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTTCCAGATCCTGTTTGGCT	0.522													22	456					0	0	1	0	0	G	82784272	C	G	82784272	3	3	30	1	0	0	0	0	1	0	0	0	11629	855	30	2	13856	2	PCLO	7	82784272	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	1193023	82784272	76354391	57	2874										
MUC17	140453	broad.mit.edu	37	chr7	100683137	100683137	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aaacaagtactccattaactAgtatgcctgtcaaccacacg	5	12	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:100683137A>T	ENST00000306151.4	+	3	8504	c.8440A>T	c.(8440-8442)Agt>Tgt	p.S2814C		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2814	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCATTAACTAGTATGCCTGT	0.498													137	520					0	0	1	0	0	T	100683137	A	T	100683137	3	4	30	1	0	0	0	0	1	0	0	0	10021	420	15	4	8450	4	MUC17	7	100683137	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	17898865	100683137	58455526	58	2875										
PIK3CG	5294	broad.mit.edu	37	chr7	106508093	106508093	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	atgaagccgcgcagtgctgcGgccagcctgtcctccatgga	13	14	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:106508093G>A	ENST00000359195.3	+	2	397	c.87G>A	c.(85-87)gcG>gcA	p.A29A	PIK3CG_ENST00000496166.1_Silent_p.A29A|PIK3CG_ENST00000440650.2_Silent_p.A29A	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	29					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GCAGTGCTGCGGCCAGCCTGT	0.637													19	140					0	0	1	0	0	A	106508093	G	A	106508093	2	1	30	1	0	0	0	0	0	0	0	1	11963	1103	39	1		1	PIK3CG	7	106508093	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	5824956	106508093	52630570	59	2876										
TBXAS1	6916	broad.mit.edu	37	chr7	139717541	139717550	+	Frame_Shift_Del	DEL	TGCCTCGGGG	TGCCTCGGGG	-													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tcggggccggcccacggagcTgcctcggggtgcgtctaggg							TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr7:139717541_139717550delTGCCTCGGGG	ENST00000263552.6	+	16	1976_1985	c.1438_1447delTGCCTCGGGG	c.(1438-1449)tgfs	p.CLGV480fs	TBXAS1_ENST00000458722.1_Frame_Shift_Del_p.CLGV525fs|TBXAS1_ENST00000411653.1_Intron|TBXAS1_ENST00000336425.5_Frame_Shift_Del_p.CLGV479fs|TBXAS1_ENST00000436047.2_Frame_Shift_Del_p.CLGV480fs|TBXAS1_ENST00000425687.1_Frame_Shift_Del_p.CLGV412fs|TBXAS1_ENST00000448866.1_Frame_Shift_Del_p.CLGV479fs|TBXAS1_ENST00000414508.2_Intron|TBXAS1_ENST00000416849.2_Frame_Shift_Del_p.CLGV526fs	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	479					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CCCACGGAGCTGCCTCGGGGTGCGTCTAGG	0.681													13	111	---	---	---	---						-	139717550	TGCCTCGGGG	-	139717541	7	5	30	1	0	1	0	1	0	0	0	0	15723	1580	55	0	1626	0	TBXAS1	7	139717541	Frame_Shift_Del	DEL	TGCCTCGGGG	TCGA-N8-A4PP-01A-11D-A28R-08	33209448	139717541	19421122	60	2877										
PLAG1	5324	broad.mit.edu	37	chr8	57079313	57079313	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aactgaacggatatttgaaaGaaaggtggtgagagggatga	15	2	0	5			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr8:57079313G>T	ENST00000316981.3	-	5	1471	c.992C>A	c.(991-993)tCt>tAt	p.S331Y	PLAG1_ENST00000429357.2_Missense_Mutation_p.S331Y|PLAG1_ENST00000423799.2_Missense_Mutation_p.S249Y	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	331	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			ATATTTGAAAGAAAGGTGGTG	0.418			T	"TCEA1, LIFR, CTNNB1, CHCHD7"	salivary adenoma								33	262					9.78485e-24	1.13477e-23	1	1	0	T	57079313	G	T	57079313	3	4	30	1	0	0	0	0	1	0	0	0	12065	942	33	2	514	2	PLAG1	8	57079313	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		57079313	89284709	61	2878										
ZFHX4	79776	broad.mit.edu	37	chr8	77767179	77767179	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gtgggtccagcacagtctcaTaaacggtgtccgttttgccg	12	11	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr8:77767179T>C	ENST00000521891.2	+	10	8470	c.8022T>C	c.(8020-8022)caT>caC	p.H2674H	ZFHX4_ENST00000455469.2_Silent_p.H2629H|ZFHX4_ENST00000050961.6_Silent_p.H2629H|ZFHX4_ENST00000518282.1_Silent_p.H2648H	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2629						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACAGTCTCATAAACGGTGTC	0.542										HNSCC(33;0.089)			23	96					0	0	1	0	0	C	77767179	T	C	77767179	2	2	30	1	0	0	0	0	0	0	0	1	17692	1403	49	4		4	ZFHX4	8	77767179	Silent	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	20687866	77767179	68596843	62	2879										
C9orf84	158401	broad.mit.edu	37	chr9	114467555	114467555	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tagcagctgaagtatgtctgGagtattaagaagtccttcag	11	6	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr9:114467555G>A	ENST00000394779.3	-	17	2762	c.2518C>T	c.(2518-2520)Cca>Tca	p.P840S	C9orf84_ENST00000394777.4_Missense_Mutation_p.P805S|C9orf84_ENST00000318737.4_Missense_Mutation_p.P879S|C9orf84_ENST00000374287.3_Missense_Mutation_p.P879S	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	879										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AGTATGTCTGGAGTATTAAGA	0.338													7	41					0	0	1	0	0	A	114467555	G	A	114467555	3	1	30	1	0	0	0	0	1	0	0	0	2518	1174	41	3	1731	3	C9orf84	9	114467555	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		114467555	26745876	63	2880										
DAB2IP	153090	broad.mit.edu	37	chr9	124535481	124535481	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggcccggtgagctggcacggCgacagatgtcactgactgaa	15	11	1	4			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr9:124535481C>G	ENST00000408936.3	+	12	2856	c.2674C>G	c.(2674-2676)Cga>Gga	p.R892G	DAB2IP_ENST00000309989.1_Missense_Mutation_p.R768G|DAB2IP_ENST00000259371.2_Missense_Mutation_p.R864G			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	892					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GCTGGCACGGCGACAGATGTC	0.677													3	7					0	0	1	0	0	G	124535481	C	G	124535481	3	3	30	1	0	0	0	0	1	0	0	0	4243	760	27	5	2636	5	DAB2IP	9	124535481	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	10067926	124535481	16677950	64	2881										
COL5A1	1289	broad.mit.edu	37	chr9	137620521	137620521	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gcaattcgctttcagtacacGgaaggagacggcgagggtga	15	8	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr9:137620521G>T	ENST00000371817.3	+	6	1206	c.792G>T	c.(790-792)acG>acT	p.T264T		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	264	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TTCAGTACACGGAAGGAGACG	0.612													36	155					1.06647e-15	1.20338e-15	1	1	0	T	137620521	G	T	137620521	2	4	30	1	0	0	0	0	0	0	0	1	3719	1103	39	5		5	COL5A1	9	137620521	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	13085040	137620521	3592910	65	2882										
ITIH5	80760	broad.mit.edu	37	chr10	7605313	7605313	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tggctgggccctgcagggtcTtctgtgagtctggcatcctg	15	11	3	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:7605313T>C	ENST00000256861.6	-	14	2640	c.2562A>G	c.(2560-2562)gaA>gaG	p.E854E	ITIH5_ENST00000446830.2_Silent_p.E636E|ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000298441.6_Silent_p.E640E	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	854					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CTGCAGGGTCTTCTGTGAGTC	0.567													5	45					0	0	1	0	0	C	7605313	T	C	7605313	2	2	30	1	0	0	0	0	0	0	0	1	7950	1606	56	4		4	ITIH5	10	7605313	Silent	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		7605313	127929434	66	2883										
ITGB1	3688	broad.mit.edu	37	chr10	33200429	33200429	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cacatctcacacgtttgcccTtgaaacttcggatctgtaca	6	13	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:33200429T>A	ENST00000396033.2	-	13	2013	c.1878A>T	c.(1876-1878)caA>caT	p.Q626H	ITGB1_ENST00000374956.4_Missense_Mutation_p.Q626H|ITGB1_ENST00000423113.1_Missense_Mutation_p.Q626H|ITGB1_ENST00000302278.3_Missense_Mutation_p.Q626H	NM_133376.2	NP_596867.1	P05556	ITB1_HUMAN	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	626	Cysteine-rich tandem repeats.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ACGTTTGCCCTTGAAACTTCG	0.468													28	144					0	0	1	0	0	A	33200429	T	A	33200429	3	1	30	1	0	0	0	0	1	0	0	0	7933	1606	56	4	772	4	ITGB1	10	33200429	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	25595116	33200429	102334318	67	2884										
ZNF37A	7587	broad.mit.edu	37	chr10	38406502	38406502	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tggcatcagaaaattaaaaaTtgggaacaatcttttgaata	7	4	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:38406502T>G	ENST00000351773.3	+	8	1253	c.423T>G	c.(421-423)aaT>aaG	p.N141K	ZNF37A_ENST00000361085.4_Missense_Mutation_p.N141K	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	141						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						AAATTAAAAATTGGGAACAAT	0.358													23	87					0	0	1	0	0	G	38406502	T	G	38406502	3	3	30	1	0	0	0	0	1	0	0	0	17928	1490	52	4	437	4	ZNF37A	10	38406502	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	5206073	38406502	97128245	68	2885										
C10orf53	282966	broad.mit.edu	37	chr10	50901855	50901855	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	atggacatgaggtcatcctaGagaagatagaagactggaat	12	5	1	5			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:50901855G>T	ENST00000374113.3	+	2	180	c.133G>T	c.(133-135)Gag>Tag	p.E45*	C10orf53_ENST00000535836.1_Nonsense_Mutation_p.E45*|C10orf53_ENST00000374112.3_Nonsense_Mutation_p.E45*|C10orf53_ENST00000374111.3_Nonsense_Mutation_p.E45*|CHAT_ENST00000455728.2_3'UTR			Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53	45										endometrium(1)|lung(6)	7		all_neural(218;0.107)				GGTCATCCTAGAGAAGATAGA	0.473													7	66					2.0095e-06	2.15119e-06	1	1	0	T	50901855	G	T	50901855	4	4	30	1	0	0	0	0	0	1	0	0	1610	943	33	2	139	2	C10orf53	10	50901855	Nonsense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	12495353	50901855	84632892	69	2886										
CCDC6	8030	broad.mit.edu	37	chr10	61666143	61666143	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cgagctgctgctgttgccccCcgccccgtccgtgtcgctct	11	19	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:61666143C>G	ENST00000263102.6	-	1	271	c.40G>C	c.(40-42)Ggg>Cgg	p.G14R		NM_005436.4	NP_005427.2	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	14						cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton		CCDC6/RET(4)	breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|stomach(1)	18				Kidney(211;0.0597)		CTGTTGCCCCCCGCCCCGTCC	0.776			T	RET	NSCLC								7	27					0	0	1	0	0	G	61666143	C	G	61666143	3	3	30	1	0	0	0	0	1	0	0	0	2850	623	22	5	1420	5	CCDC6	10	61666143	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	10764288	61666143	73868604	70	2887										
PPRC1	23082	broad.mit.edu	37	chr10	103900434	103900434	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gacccaccaaagaccatcatCcctgaagtcaaagaggttgt	8	12	2	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:103900434C>A	ENST00000278070.2	+	5	2208	c.2169C>A	c.(2167-2169)atC>atA	p.I723I	PPRC1_ENST00000413464.2_Silent_p.I723I	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	723					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGACCATCATCCCTGAAGTCA	0.537													22	146					7.45023e-12	8.23965e-12	1	1	0	A	103900434	C	A	103900434	2	1	30	1	0	0	0	0	0	0	0	1	12458	845	30	2		2	PPRC1	10	103900434	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	42234291	103900434	31634313	71	2888										
SORCS1	114815	broad.mit.edu	37	chr10	108366950	108366950	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	caggtcatcagttgacctttTgttttctccagctggatcct	8	11	3	1	rs144896133		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:108366950T>A	ENST00000263054.6	-	23	3146	c.3139A>T	c.(3139-3141)Aaa>Taa	p.K1047*	SORCS1_ENST00000344440.6_Nonsense_Mutation_p.K1047*|SORCS1_ENST00000369698.1_Nonsense_Mutation_p.K582*|SORCS1_ENST00000478809.2_5'UTR	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1047						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GTTGACCTTTTGTTTTCTCCA	0.522													18	42					0	0	1	0	0	A	108366950	T	A	108366950	4	1	30	1	0	0	0	0	0	1	0	0	14983	1821	63	4	617	4	SORCS1	10	108366950	Nonsense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	4466516	108366950	27167797	72	2889										
DUSP5	1847	broad.mit.edu	37	chr10	112266691	112266692	+	Splice_Site	INS	-	-	G													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gtcctttgtccctgcatccaINSgggtggcccagttgaaatcc							TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:112266691_112266692insG	ENST00000369583.3	+	3	812		c.e3-1		DUSP5_ENST00000468749.1_Splice_Site	NM_004419.3	NP_004410.3	Q16690	DUS5_HUMAN	dual specificity phosphatase 5						endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			kidney(2)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	13		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		CCCTGCATCCAGGGTGGCCCAG	0.48													8	302	---	---	---	---						G	112266692	-	G	112266691	8	5	30	1	0	1	1	0	0	0	1	0	4854	202	7	0	537	0	DUSP5	10	112266691	Splice_Site	INS	-	TCGA-N8-A4PP-01A-11D-A28R-08	3899741	112266691	23268056	73	2890										
PDCD4	27250	broad.mit.edu	37	chr10	112650324	112650324	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttctctgtagagctgctctgGataaggctaccgtgcttctg	11	10	3	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:112650324G>T	ENST00000393104.2	+	9	1213	c.853G>T	c.(853-855)Gat>Tat	p.D285Y	PDCD4_ENST00000280154.7_Missense_Mutation_p.D296Y|PDCD4_ENST00000481353.1_3'UTR	NM_145341.3	NP_663314.1	Q53EL6	PDCD4_HUMAN	programmed cell death 4 (neoplastic transformation inhibitor)	296					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	13		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		AGCTGCTCTGGATAAGGCTAC	0.408													10	69					3.86212e-05	4.08211e-05	1	1	0	T	112650324	G	T	112650324	3	4	30	1	0	0	0	0	1	0	0	0	11667	1174	41	2	926	2	PDCD4	10	112650324	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	383633	112650324	22884423	74	2891										
TACC2	10579	broad.mit.edu	37	chr10	123844255	123844255	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cacattggaaataaggaagaTgggcagctgtgatggggagg	17	4	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr10:123844255T>C	ENST00000369005.1	+	4	2580	c.2240T>C	c.(2239-2241)aTg>aCg	p.M747T	TACC2_ENST00000515603.1_Missense_Mutation_p.M747T|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515273.1_Missense_Mutation_p.M747T|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000453444.2_Missense_Mutation_p.M747T|TACC2_ENST00000334433.3_Missense_Mutation_p.M747T	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	747						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ATAAGGAAGATGGGCAGCTGT	0.542													25	156					0	0	1	0	0	C	123844255	T	C	123844255	3	2	30	1	0	0	0	0	1	0	0	0	15558	1464	51	4	2250	4	TACC2	10	123844255	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	11193931	123844255	11690492	75	2892										
RRAS2	22800	broad.mit.edu	37	chr11	14316390	14316390	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tcatggctccaaactcttctTgtcctgctgtatccaaaact	5	13	3	0	rs113954997		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:14316390T>A	ENST00000545643.1	-	3	546	c.233A>T	c.(232-234)cAa>cTa	p.Q78L	RRAS2_ENST00000534746.1_5'UTR|RRAS2_ENST00000529237.1_5'UTR|RRAS2_ENST00000414023.2_5'UTR|RRAS2_ENST00000537760.1_Missense_Mutation_p.Q37L|RRAS2_ENST00000526063.1_5'UTR|RRAS2_ENST00000532814.1_5'UTR|RRAS2_ENST00000256196.4_Missense_Mutation_p.Q72L	NM_012250.5	NP_036382.2	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2	72						endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding	p.Q72L(2)		breast(3)|endometrium(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	12				Epithelial(150;0.203)		AAACTCTTCTTGTCCTGCTGT	0.393													88	91					0	0	1	0	0	A	14316390	T	A	14316390	3	1	30	1	0	0	0	0	1	0	0	0	13728	1812	63	4	415	4	RRAS2	11	14316390	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08		14316390	120690126	76	2893										
PAMR1	25891	broad.mit.edu	37	chr11	35454241	35454241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgtcgttcttgaagccagggCtcctcacgtctgccaggaca	11	13	3	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:35454241C>T	ENST00000378880.2	-	11	2271	c.1826G>A	c.(1825-1827)aGc>aAc	p.S609N	PAMR1_ENST00000532848.1_Missense_Mutation_p.S569N|PAMR1_ENST00000278360.3_Missense_Mutation_p.S626N|PAMR1_ENST00000378878.3_Missense_Mutation_p.S498N	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	609	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						GAAGCCAGGGCTCCTCACGTC	0.607													11	43					0	0	1	0	0	T	35454241	C	T	35454241	3	4	30	1	0	0	0	0	1	0	0	0	11459	797	28	3	340	3	PAMR1	11	35454241	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	21137851	35454241	99552275	77	2894										
OR9G4	283189	broad.mit.edu	37	chr11	56510657	56510657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cacaccaagcaggactttttCgtagaccctggtgtttgtac	9	11	0	1	rs147669235		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:56510657C>T	ENST00000302957.3	-	1	630	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E211K(1)		NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGGACTTTTTCGTAGACCCTG	0.438													14	58					0	0	1	0	0	T	56510657	C	T	56510657	3	4	30	1	0	0	0	0	1	0	0	0	11297	893	31	1	355	1	OR9G4	11	56510657	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	21056416	56510657	78495859	78	2895										
DAGLA	747	broad.mit.edu	37	chr11	61511823	61511823	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tccttcccgctcagctcctcGggtgagctcatggacctgac	10	16	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:61511823G>C	ENST00000257215.5	+	20	3107	c.2991G>C	c.(2989-2991)tcG>tcC	p.S997S		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	997					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		TCAGCTCCTCGGGTGAGCTCA	0.677													23	90					0	0	1	0	0	C	61511823	G	C	61511823	2	2	30	1	0	0	0	0	0	0	0	1	4250	1103	39	5		5	DAGLA	11	61511823	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	5001166	61511823	73494693	79	2896										
CWF19L2	143884	broad.mit.edu	37	chr11	107205621	107205621	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	acttacagactttctgatatCttttgaagagagatctatca	6	7	4	5			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:107205621C>A	ENST00000282251.5	-	16	2452	c.2425G>T	c.(2425-2427)Gat>Tat	p.D809Y		NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	809							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TTTCTGATATCTTTTGAAGAG	0.333													31	43					8.88839e-20	1.01669e-19	1	1	0	A	107205621	C	A	107205621	3	1	30	1	0	0	0	0	1	0	0	0	4095	913	32	2	271	2	CWF19L2	11	107205621	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	45693798	107205621	27800895	80	2897										
TMPRSS5	80975	broad.mit.edu	37	chr11	113567582	113567582	+	Frame_Shift_Del	DEL	G	G	-													0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cagcctcagtagtcctacctGggctgccacgcctcctccag							TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:113567582delG	ENST00000299882.5	-	6	724	c.576delC	c.(574-576)ccfs	p.P192fs	TMPRSS5_ENST00000545579.1_Frame_Shift_Del_p.P183fs|TMPRSS5_ENST00000536856.1_5'UTR|TMPRSS5_ENST00000544634.1_Frame_Shift_Del_p.P192fs|TMPRSS5_ENST00000540540.1_5'UTR|TMPRSS5_ENST00000538955.1_Frame_Shift_Del_p.P148fs|TMPRSS5_ENST00000544476.1_Frame_Shift_Del_p.P148fs	NM_030770.2	NP_110397.2	Q9H3S3	TMPS5_HUMAN	transmembrane protease, serine 5	192	SRCR.				proteolysis	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10		all_cancers(61;2.71e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.75e-06)|Epithelial(105;6.34e-05)|all cancers(92;0.000502)		AGTCCTACCTGGGCTGCCACG	0.547													2	4	---	---	---	---						-	113567582	G	-	113567582	7	5	30	1	0	1	0	1	0	0	0	0	16309	1335	47	0	829	0	TMPRSS5	11	113567582	Frame_Shift_Del	DEL	G	TCGA-N8-A4PP-01A-11D-A28R-08	6361961	113567582	21438934	81	2898										
TBCEL	219899	broad.mit.edu	37	chr11	120925929	120925929	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ctggataccctcgtcctggcCaacaatcatttgaatgctat	7	12	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:120925929C>A	ENST00000422003.2	+	5	812	c.624C>A	c.(622-624)gcC>gcA	p.A208A	TBCEL_ENST00000529397.1_Silent_p.A208A	NM_152715.3	NP_689928.3	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	208						cytoplasm|cytoskeleton			TECTA/TBCEL(2)	endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TCGTCCTGGCCAACAATCATT	0.438													9	43					0.000274275	0.000286275	1	1	0	A	120925929	C	A	120925929	2	1	30	1	0	0	0	0	0	0	0	1	15694	581	21	5		5	TBCEL	11	120925929	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	7358347	120925929	14080587	82	2899										
OR8D1	283159	broad.mit.edu	37	chr11	124180410	124180410	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgtattcttctttcctaggaAgttcaccagcattttgggag	9	8	3	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr11:124180410A>C	ENST00000357821.2	-	1	323	c.253T>G	c.(253-255)Ttc>Gtc	p.F85V		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TTTCCTAGGAAGTTCACCAGC	0.468													16	44					0	0	1	0	0	C	124180410	A	C	124180410	3	2	30	1	0	0	0	0	1	0	0	0	11277	72	3	4	676	4	OR8D1	11	124180410	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	3254481	124180410	10826106	83	2900										
IRAK4	51135	broad.mit.edu	37	chr12	44165125	44165125	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggtgatcttgtggatcttttGatccaaaatgaattttttgc	9	5	2	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:44165125G>C	ENST00000448290.2	+	3	335	c.264G>C	c.(262-264)ttG>ttC	p.L88F	IRAK4_ENST00000551736.1_Missense_Mutation_p.L88F|IRAK4_ENST00000440781.2_Intron|IRAK4_ENST00000431837.1_Intron	NM_016123.3	NP_057207.2	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	88	Death.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity					all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TGGATCTTTTGATCCAAAATG	0.418													11	51					0	0	1	0	0	C	44165125	G	C	44165125	3	2	30	1	0	0	0	0	1	0	0	0	7868	1281	45	2	270	2	IRAK4	12	44165125	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		44165125	89686770	84	2901										
SENP1	29843	broad.mit.edu	37	chr12	48468234	48468234	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tctggggtataagaagatagGgaatatacactgtgggacag	14	4	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:48468234G>T	ENST00000004980.5	-	8	1291	c.813C>A	c.(811-813)tcC>tcA	p.S271S	SENP1_ENST00000549595.1_Silent_p.S271S|SENP1_ENST00000551330.1_Silent_p.S271S|SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000448372.1_Silent_p.S271S|SENP1_ENST00000549518.1_Silent_p.S271S			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	271					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				AAGAAGATAGGGAATATACAC	0.433													21	125					3.51602e-12	3.9145e-12	1	1	0	T	48468234	G	T	48468234	2	4	30	1	0	0	0	0	0	0	0	1	14099	1219	43	5		5	SENP1	12	48468234	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	4303109	48468234	85383661	85	2902										
KRT18	3875	broad.mit.edu	37	chr12	53343316	53343316	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggagcacttggagaagaaggGaccccaggtcagagactgga	16	8	1	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:53343316G>A	ENST00000550600.1	+	2	413	c.359G>A	c.(358-360)gGa>gAa	p.G120E	KRT8_ENST00000546897.1_Intron|KRT18_ENST00000388835.3_Missense_Mutation_p.G120E|KRT8_ENST00000552551.1_5'UTR|KRT8_ENST00000549198.1_5'UTR|KRT18_ENST00000388837.2_Missense_Mutation_p.G120E			P05783	K1C18_HUMAN	keratin 18	120	Interaction with TRADD.|Linker 1.|Necessary for interaction with PNN.|Rod.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						GAGAAGAAGGGACCCCAGGTC	0.587													21	84					0	0	1	0	0	A	53343316	G	A	53343316	3	1	30	1	0	0	0	0	1	0	0	0	8497	1174	41	3	361	3	KRT18	12	53343316	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	4875082	53343316	80508579	86	2903										
SMARCC2	6601	broad.mit.edu	37	chr12	56568509	56568509	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	agatactcttgggggttcagTcggtaagtgtcaatcataaa	11	6	4	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:56568509T>G	ENST00000394023.3	-	16	1527	c.1422A>C	c.(1420-1422)cgA>cgC	p.R474R	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000347471.4_Silent_p.R474R|SMARCC2_ENST00000550164.1_Silent_p.R474R|SMARCC2_ENST00000267064.4_Silent_p.R474R	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	474	SWIRM.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGGGTTCAGTCGGTAAGTGT	0.468													14	147					0	0	1	0	0	G	56568509	T	G	56568509	2	3	30	1	0	0	0	0	0	0	0	1	14829	1654	58	4		4	SMARCC2	12	56568509	Silent	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	3225193	56568509	77283386	87	2904										
AVIL	10677	broad.mit.edu	37	chr12	58197161	58197161	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	acgagactggacatctaggaTttcctgctgaagtctgcaat	10	9	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:58197161T>C	ENST00000537081.1	-	15	1809	c.1810A>G	c.(1810-1812)Atc>Gtc	p.I604V	AVIL_ENST00000550083.1_5'UTR|TSFM_ENST00000548851.1_Intron|AVIL_ENST00000257861.3_Missense_Mutation_p.I611V			O75366	AVIL_HUMAN	advillin	611	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					ACATCTAGGATTTCCTGCTGA	0.433											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	155					0	0	1	0	0	C	58197161	T	C	58197161	3	2	30	1	0	0	0	0	1	0	0	0	1225	1493	52	4	648	4	AVIL	12	58197161	Missense_Mutation	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	1628652	58197161	75654734	88	2905										
MYF6	4618	broad.mit.edu	37	chr12	81101831	81101831	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aggctaaagaaaatcaacgaGgccttcgaggcactgaagcg	12	9	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:81101831G>C	ENST00000228641.3	+	1	555	c.333G>C	c.(331-333)gaG>gaC	p.E111D		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	111	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						AAATCAACGAGGCCTTCGAGG	0.587													6	73					0	0	1	0	0	C	81101831	G	C	81101831	3	2	30	1	0	0	0	0	1	0	0	0	10075	991	35	5	335	5	MYF6	12	81101831	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	22904670	81101831	52750064	89	2906										
ASCL1	429	broad.mit.edu	37	chr12	103352601	103352601	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggcgtcctgtcgcccaccatCtcccccaactactccaacga	6	20	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:103352601C>A	ENST00000266744.3	+	1	1138	c.579C>A	c.(577-579)atC>atA	p.I193I		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	193					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						CGCCCACCATCTCCCCCAACT	0.672													17	52					1.99824e-07	2.15294e-07	1	1	0	A	103352601	C	A	103352601	2	1	30	1	0	0	0	0	0	0	0	1	1033	903	32	2		2	ASCL1	12	103352601	Silent	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	22250770	103352601	30499294	90	2907										
KIAA1033	23325	broad.mit.edu	37	chr12	105558018	105558018	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gcaacagaatgtacagtcagCcagtcaagatgaaaaactct	8	9	3	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr12:105558018C>G	ENST00000332180.5	+	31	3374	c.3287C>G	c.(3286-3288)gCc>gGc	p.A1096G	KIAA1033_ENST00000547171.1_3'UTR	NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	1096					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						GTACAGTCAGCCAGTCAAGAT	0.433													7	32					0	0	1	0	0	G	105558018	C	G	105558018	3	3	30	1	0	0	0	0	1	0	0	0	8247	739	26	5	3409	5	KIAA1033	12	105558018	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	2205417	105558018	28293877	91	2908										
RPL21	6144	broad.mit.edu	37	chr13	27827919	27827919	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cagtaattcgccaaaatgacGaacacaaagggaaagaggag	11	7	0	2	rs112351536		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr13:27827919G>A	ENST00000311549.6	+	2	295	c.6G>A	c.(4-6)acG>acA	p.T2T	RPL21_ENST00000319826.4_Silent_p.T2T|RPL21_ENST00000326092.4_Silent_p.T2T|RPL21_ENST00000272274.4_Silent_p.T2T	NM_000982.3	NP_000973.2	P46778	RL21_HUMAN	ribosomal protein L21	2					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(1)	2		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0287)|OV - Ovarian serous cystadenocarcinoma(117;0.118)|Epithelial(112;0.139)|GBM - Glioblastoma multiforme(144;0.21)		CCAAAATGACGAACACAAAGG	0.418													8	39					0	0	1	0	0	A	27827919	G	A	27827919	2	1	30	1	0	0	0	0	0	0	0	1	13618	1045	37	1		1	RPL21	13	27827919	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		27827919	87341959	92	2909										
FLT1	2321	broad.mit.edu	37	chr13	28931761	28931761	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gctttgcagtgatagacaccTtcatcctcttctgtgactct	7	12	4	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr13:28931761T>C	ENST00000282397.4	-	15	2429	c.2178A>G	c.(2176-2178)gaA>gaG	p.E726E		NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	726	Ig-like C2-type 7.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GATAGACACCTTCATCCTCTT	0.453													20	71					0	0	1	0	0	C	28931761	T	C	28931761	2	2	30	1	0	0	0	0	0	0	0	1	5973	1606	56	4		4	FLT1	13	28931761	Silent	SNP	T	TCGA-N8-A4PP-01A-11D-A28R-08	1103842	28931761	86238117	93	2910										
EDNRB	1910	broad.mit.edu	37	chr13	78475270	78475270	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	acaggtcattagtgtataaaAaaatgcagtgatggccaatg	10	5	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr13:78475270A>C	ENST00000377211.4	-	5	1296	c.1144T>G	c.(1144-1146)Ttt>Gtt	p.F382V	EDNRB_ENST00000446573.1_Missense_Mutation_p.F292V|EDNRB_ENST00000334286.5_Missense_Mutation_p.F292V	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	292					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	AGTGTATAAAAAAATGCAGTG	0.338													4	34					0	0	1	0	0	C	78475270	A	C	78475270	3	2	30	1	0	0	0	0	1	0	0	0	4946	14	1	4	591	4	EDNRB	13	78475270	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	49543509	78475270	36694608	94	2911										
APEX1	328	broad.mit.edu	37	chr14	20925652	20925652	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gatcactgtcctatcaccctAtacctagcactgtgacacca	5	15	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr14:20925652A>T	ENST00000216714.3	+	5	1210	c.942A>T	c.(940-942)ctA>ctT	p.L314L	APEX1_ENST00000555414.1_Silent_p.L314L|APEX1_ENST00000398030.4_Silent_p.L314L|APEX1_ENST00000557054.1_3'UTR	NM_001244249.1|NM_001641.3	NP_001231178.1|NP_001632.2	P27695	APEX1_HUMAN	APEX nuclease (multifunctional DNA repair enzyme) 1	314	Mitochondrial targeting sequence (MTS).				base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			breast(2)|endometrium(1)|large_intestine(4)|ovary(2)	9	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	CTATCACCCTATACCTAGCAC	0.473								Other BER factors					12	154					0	0	1	0	0	T	20925652	A	T	20925652	2	4	30	1	0	0	0	0	0	0	0	1	765	436	16	4		4	APEX1	14	20925652	Silent	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08		20925652	86423888	95	2912										
OTUD7A	161725	broad.mit.edu	37	chr15	31776314	31776314	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gcgcgctcgtcaggtagtagCcgatcatctcctcgtggaac	12	13	3	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr15:31776314C>A	ENST00000382902.1	-	11	2077	c.1985G>T	c.(1984-1986)gGc>gTc	p.G662V	OTUD7A_ENST00000307050.4_Missense_Mutation_p.G655V			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	655						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CAGGTAGTAGCCGATCATCTC	0.721													4	15					0.00116845	0.00120451	1	1	0	A	31776314	C	A	31776314	3	1	30	1	0	0	0	0	1	0	0	0	11364	739	26	5	820	5	OTUD7A	15	31776314	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08		31776314	70755078	96	2913										
MMP25	64386	broad.mit.edu	37	chr16	3107137	3107137	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tccattatgaggcccttctaCcagggtccggtgggcgaccc	12	14	1	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:3107137C>A	ENST00000336577.4	+	5	1002	c.765C>A	c.(763-765)taC>taA	p.Y255*	RP11-473M20.7_ENST00000572574.1_RNA|RP11-473M20.7_ENST00000573878.1_RNA|RP11-473M20.7_ENST00000570949.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	255					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						GGCCCTTCTACCAGGGTCCGG	0.642													66	164					3.57465e-26	4.17459e-26	1	1	0	A	3107137	C	A	3107137	4	1	30	1	0	0	0	0	0	1	0	0	9710	518	18	5	783	5	MMP25	16	3107137	Nonsense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08		3107137	87247616	97	2914										
CREBBP	1387	broad.mit.edu	37	chr16	3820578	3820578	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cagagaggcttaccggtgtgCcaggaggctgggcgtgcaca	17	10	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:3820578C>T	ENST00000262367.5	-	14	3682	c.2873G>A	c.(2872-2874)gGc>gAc	p.G958D	CREBBP_ENST00000382070.3_Missense_Mutation_p.G920D	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	958					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TACCGGTGTGCCAGGAGGCTG	0.577			"T, N, F, Mis, O"	"MLL, MORF, RUNXBP2"	"ALL, AML, DLBCL, B-NHL "		Rubinstein-Taybi syndrome						5	297					0	0	1	0	0	T	3820578	C	T	3820578	3	4	30	1	0	0	0	0	1	0	0	0	3884	739	26	3	4527	3	CREBBP	16	3820578	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	713441	3820578	86534175	98	2915										
RBBP6	5930	broad.mit.edu	37	chr16	24581363	24581363	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	agaaggactattccaaagatGtcaaatcagaaaagctaaca	7	7	2	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:24581363G>A	ENST00000319715.4	+	17	3784	c.3352G>A	c.(3352-3354)Gtc>Atc	p.V1118I	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Missense_Mutation_p.V1084I	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1118	Interaction with RB1 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TTCCAAAGATGTCAAATCAGA	0.363													5	19					0	0	1	0	0	A	24581363	G	A	24581363	3	1	30	1	0	0	0	0	1	0	0	0	13154	1377	48	3	3472	3	RBBP6	16	24581363	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	20760785	24581363	65773390	99	2916										
SIAH1	6477	broad.mit.edu	37	chr16	48395562	48395562	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aagctgtgcaatgctggtgtCaaagactagacagtcgctat	11	8	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:48395562C>G	ENST00000380006.2	-	1	2231	c.778G>C	c.(778-780)Gac>Cac	p.D260H	SIAH1_ENST00000394725.2_Missense_Mutation_p.D260H|SIAH1_ENST00000356721.3_Missense_Mutation_p.D291H|LONP2_ENST00000564259.1_3'UTR			Q8IUQ4	SIAH1_HUMAN	siah E3 ubiquitin protein ligase 1	260	SBD.				axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|stomach(1)	7		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				ATGCTGGTGTCAAAGACTAGA	0.418													11	30					0	0	1	0	0	G	48395562	C	G	48395562	3	3	30	1	0	0	0	0	1	0	0	0	14353	826	29	2	74	2	SIAH1	16	48395562	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	23814199	48395562	41959191	100	2917										
SLC12A3	0	broad.mit.edu	37	chr16	56918049	56918049	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	atcatgttcctcctcacctgGtgggcggccctcatcgccat	9	16	3	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:56918049G>C	ENST00000438926.2	+	14	1787	c.1758G>C	c.(1756-1758)tgG>tgC	p.W586C	SLC12A3_ENST00000566786.1_Missense_Mutation_p.W585C|SLC12A3_ENST00000262502.5_Missense_Mutation_p.W585C|SLC12A3_ENST00000563236.1_Missense_Mutation_p.W586C	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	586					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TCCTCACCTGGTGGGCGGCCC	0.602													10	63					0	0	1	0	0	C	56918049	G	C	56918049	3	2	30	1	0	0	0	0	1	0	0	0	14438	1270	44	5	1812	5	SLC12A3	16	56918049	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	8522487	56918049	33436704	101	2918										
GPR97	222487	broad.mit.edu	37	chr16	57717867	57717867	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttcccgggagaggttcaagtCagaagatgccccaaagatcc	11	11	2	4			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:57717867C>G	ENST00000333493.4	+	9	1066	c.905C>G	c.(904-906)tCa>tGa	p.S302*	GPR97_ENST00000327655.6_Nonsense_Mutation_p.S92*|RP11-405F3.4_ENST00000563062.1_RNA|GPR97_ENST00000450388.3_Nonsense_Mutation_p.S182*	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	302					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AGGTTCAAGTCAGAAGATGCC	0.597													13	49					0	0	1	0	0	G	57717867	C	G	57717867	4	3	30	1	0	0	0	0	0	1	0	0	6760	838	29	2	939	2	GPR97	16	57717867	Nonsense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	799818	57717867	32636886	102	2919										
ZFP90	146198	broad.mit.edu	37	chr16	68597927	68597927	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gcccatccctttataaacatAtgaggattcataagagaggc	8	9	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:68597927A>G	ENST00000570495.1	+	5	1529	c.1237A>G	c.(1237-1239)Atg>Gtg	p.M413V	ZFP90_ENST00000563169.2_Missense_Mutation_p.M413V|ZFP90_ENST00000398253.2_Missense_Mutation_p.M413V|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	413					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TTATAAACATATGAGGATTCA	0.428													13	67					0	0	1	0	0	G	68597927	A	G	68597927	3	3	30	1	0	0	0	0	1	0	0	0	17711	449	16	4	1251	4	ZFP90	16	68597927	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	10880060	68597927	21756826	103	2920										
PDPR	55066	broad.mit.edu	37	chr16	70187451	70187451	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cacgcccctggaatgtggacGagagtctcgggtgaaattag	14	9	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr16:70187451G>T	ENST00000288050.4	+	18	3167	c.2210G>T	c.(2209-2211)cGa>cTa	p.R737L	PDPR_ENST00000542659.1_Missense_Mutation_p.R82L|PDPR_ENST00000568530.1_Missense_Mutation_p.R737L|PDPR_ENST00000567046.1_Missense_Mutation_p.R95L|PDPR_ENST00000398122.3_Missense_Mutation_p.R637L|PDPR_ENST00000562100.1_Intron	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	737					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		GAATGTGGACGAGAGTCTCGG	0.473													3	23					0.00909568	0.00920593	1	1	0	T	70187451	G	T	70187451	3	4	30	1	0	0	0	0	1	0	0	0	11735	1058	37	2	2272	2	PDPR	16	70187451	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	1589524	70187451	20167302	104	2921										
SLC16A11	162515	broad.mit.edu	37	chr17	6946803	6946803	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	accacccagccccagcccccAtccgggggtccggcgggctg	13	20	0	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr17:6946803A>G	ENST00000308009.1	-	1	439	c.102T>C	c.(100-102)gaT>gaC	p.D34D	SLC16A11_ENST00000447225.1_Silent_p.D10D	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	34						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						CCCAGCCCCCATCCGGGGGTC	0.706													6	26					0	0	1	0	0	G	6946803	A	G	6946803	2	3	30	1	0	0	0	0	0	0	0	1	14458	214	8	4		4	SLC16A11	17	6946803	Silent	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08		6946803	74248407	105	2922										
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	16	11	1	1	rs121912651		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr17:7577539G>A	ENST00000420246.2	-	7	874	c.742C>T	c.(742-744)Cgg>Tgg	p.R248W	TP53_ENST00000455263.2_Missense_Mutation_p.R248W|TP53_ENST00000445888.2_Missense_Mutation_p.R248W|TP53_ENST00000413465.2_Missense_Mutation_p.R248W|TP53_ENST00000359597.4_Missense_Mutation_p.R248W|TP53_ENST00000269305.4_Missense_Mutation_p.R248W	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248W(544)|p.R155W(28)|p.R248G(12)|p.0?(8)|p.?(5)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248R(2)|p.R248fs*>39(1)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(786O_KIDNEY)|R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO320_LARGE_INTESTINE)|R248W(COLO680N_OESOPHAGUS)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(GCT_SOFT_TISSUE)|R248W(HCC2157_BREAST)|R248W(JIMT1_BREAST)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(LUDLU1_LUNG)|R248W(LXF289_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(RD_SOFT_TISSUE)|R248W(SW837_LARGE_INTESTINE)|R248W(VCAP_PROSTATE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			35	33					0	0	1	0	0	A	7577539	G	A	7577539	3	1	30	1	0	0	0	0	1	0	0	0	16441	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	630736	7577539	73617671	106	2923										
C17orf59	54785	broad.mit.edu	37	chr17	8092945	8092945	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gccaccgcacgcctcgctcaGcccgtccaggctgcggctgt	12	19	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr17:8092945G>A	ENST00000389017.4	-	1	619	c.514C>T	c.(514-516)Ctg>Ttg	p.L172L		NM_017622.2	NP_060092.2	Q96GS4	CQ059_HUMAN	chromosome 17 open reading frame 59	172										large_intestine(2)|lung(3)|urinary_tract(1)	6						GCCTCGCTCAGCCCGTCCAGG	0.736													12	28					0	0	1	0	0	A	8092945	G	A	8092945	2	1	30	1	0	0	0	0	0	0	0	1	1876	962	34	3		3	C17orf59	17	8092945	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	515406	8092945	73102265	107	2924										
CCL13	6357	broad.mit.edu	37	chr17	32685137	32685137	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cctgggccggaaagctcacaCcctgaagacttgaactctgc	10	14	2	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr17:32685137C>G	ENST00000225844.2	+	3	359	c.284C>G	c.(283-285)aCc>aGc	p.T95S		NM_005408.2	NP_005399.1	Q99616	CCL13_HUMAN	chemokine (C-C motif) ligand 13	95				AHTLKT -> LTP (in Ref. 12; CAB01111).	cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|prostate(1)	2		Ovarian(249;0.0443)|Breast(31;0.151)				AAAGCTCACACCCTGAAGACT	0.483													11	51					0	0	1	0	0	G	32685137	C	G	32685137	3	3	30	1	0	0	0	0	1	0	0	0	2904	507	18	5	294	5	CCL13	17	32685137	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	24592192	32685137	48510073	108	2925										
KRT37	8688	broad.mit.edu	37	chr17	39580586	39580586	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gggcagacagaggctggggcGgcccaggggagtcgacccca	19	12	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr17:39580586G>A	ENST00000225550.3	-	1	189	c.190C>T	c.(190-192)Cgc>Tgc	p.R64C	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	64	Head.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				AGGCTGGGGCGGCCCAGGGGA	0.642													4	97					0	0	1	0	0	A	39580586	G	A	39580586	3	1	30	1	0	0	0	0	1	0	0	0	8516	1116	39	1	1187	1	KRT37	17	39580586	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	6895449	39580586	41614624	109	2926										
CYTH1	9267	broad.mit.edu	37	chr17	76694918	76694918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttacccggaggagctcctccGgcaggtctcccccatcattg	10	16	2	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr17:76694918G>A	ENST00000589297.1	-	8	1198	c.506C>T	c.(505-507)cCg>cTg	p.P169L	CYTH1_ENST00000591455.1_Missense_Mutation_p.P228L|CYTH1_ENST00000585509.1_Missense_Mutation_p.P169L|CYTH1_ENST00000589296.1_Intron|CYTH1_ENST00000446868.3_Missense_Mutation_p.P228L|CYTH1_ENST00000361101.4_Missense_Mutation_p.P228L			Q15438	CYH1_HUMAN	cytohesin 1	228	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						GAGCTCCTCCGGCAGGTCTCC	0.483													75	194					0	0	1	0	0	A	76694918	G	A	76694918	3	1	30	1	0	0	0	0	1	0	0	0	4226	1116	39	1	537	1	CYTH1	17	76694918	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	37114332	76694918	4500292	110	2927										
NAPG	8774	broad.mit.edu	37	chr18	10540013	10540013	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aaaatgttgatccagagaagGctgtacagttatatcaacag	9	6	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr18:10540013G>A	ENST00000322897.6	+	7	466	c.397G>A	c.(397-399)Gct>Act	p.A133T	NAPG_ENST00000542979.1_Missense_Mutation_p.A51T	NM_003826.2	NP_003817.1	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, gamma	133					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding			large_intestine(2)|lung(2)	4						TCCAGAGAAGGCTGTACAGTT	0.289													6	11					0	0	1	0	0	A	10540013	G	A	10540013	3	1	30	1	0	0	0	0	1	0	0	0	10211	1203	42	3	423	3	NAPG	18	10540013	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		10540013	67537235	111	2928										
ACTL9	284382	broad.mit.edu	37	chr19	8807988	8807988	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	gagcgcgcagcagctctgccCggaagcgaccctcgaagccg	14	16	1	0			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:8807988C>T	ENST00000324436.3	-	1	1184	c.1064G>A	c.(1063-1065)cGg>cAg	p.R355Q		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	355						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						CAGCTCTGCCCGGAAGCGACC	0.652													26	72					0	0	1	0	0	T	8807988	C	T	8807988	3	4	30	1	0	0	0	0	1	0	0	0	203	652	23	1	190	1	ACTL9	19	8807988	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08		8807988	50320995	112	2929										
MUC16	94025	broad.mit.edu	37	chr19	9064668	9064668	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	agatgtcttgtgacattgtgGactgctcagggcctgacatg	13	8	2	3			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:9064668G>C	ENST00000397910.4	-	3	22981	c.22778C>G	c.(22777-22779)tCc>tGc	p.S7593C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7595	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGACATTGTGGACTGCTCAGG	0.483													14	88					0	0	1	0	0	C	9064668	G	C	9064668	3	2	30	1	0	0	0	0	1	0	0	0	10020	1174	41	2	21073	2	MUC16	19	9064668	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	256680	9064668	50064315	113	2930										
CCDC159	126075	broad.mit.edu	37	chr19	11462749	11462749	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	acagaagcgcaggaggatgaGatctcagagaacttggtgaa	14	6	1	4			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:11462749G>A	ENST00000588790.1	+	9	954	c.507G>A	c.(505-507)gaG>gaA	p.E169E	CCDC159_ENST00000458408.1_Silent_p.E169E			P0C7I6	CC159_HUMAN	coiled-coil domain containing 159	284										endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	5						AGGAGGATGAGATCTCAGAGA	0.582													11	61					0	0	1	0	0	A	11462749	G	A	11462749	2	1	30	1	0	0	0	0	0	0	0	1	2810	933	33	3		3	CCDC159	19	11462749	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	2398081	11462749	47666234	114	2931										
FARSA	2193	broad.mit.edu	37	chr19	13039265	13039265	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aagttatcagtcggcatctcGgtgaacctggtgggagacac	13	9	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:13039265G>T	ENST00000588025.1	-	8	992	c.852C>A	c.(850-852)acC>acA	p.T284T	FARSA_ENST00000314606.4_Silent_p.T244T|FARSA_ENST00000423140.2_Silent_p.T213T			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	244					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	TCGGCATCTCGGTGAACCTGG	0.607													25	62					1.42536e-11	1.56602e-11	1	1	0	T	13039265	G	T	13039265	2	4	30	1	0	0	0	0	0	0	0	1	5711	1103	39	5		5	FARSA	19	13039265	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	1576516	13039265	46089718	115	2932										
LPHN1	22859	broad.mit.edu	37	chr19	14261831	14261831	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggccaccagggctggcgggcGcgaggtgtagtagatttcgg	19	9	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:14261831G>C	ENST00000340736.6	-	24	4576	c.4279C>G	c.(4279-4281)Cgc>Ggc	p.R1427G	LPHN1_ENST00000361434.3_Missense_Mutation_p.R1422G|CTB-55O6.12_ENST00000588658.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	1427					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCTGGCGGGCGCGAGGTGTAG	0.731													3	12					0	0	1	0	0	C	14261831	G	C	14261831	3	2	30	1	0	0	0	0	1	0	0	0	8959	1087	38	5	149	5	LPHN1	19	14261831	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	1222566	14261831	44867152	116	2933										
CYP4F2	8529	broad.mit.edu	37	chr19	15990171	15990171	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cttacctgggccctgccgagAagggaataaaagccagaggt	13	10	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:15990171A>C	ENST00000221700.5	-	12	1477	c.1382T>G	c.(1381-1383)tTc>tGc	p.F461C	CYP4F2_ENST00000592328.1_Missense_Mutation_p.F461C	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	461					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CCCTGCCGAGAAGGGAATAAA	0.577													7	328					0	0	1	0	0	C	15990171	A	C	15990171	3	2	30	1	0	0	0	0	1	0	0	0	4211	246	9	4	188	4	CYP4F2	19	15990171	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	1728340	15990171	43138812	117	2934										
NOVA2	4858	broad.mit.edu	37	chr19	46443289	46443289	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ttggagatctggatgcgagcGcccgtcagctcctggtactc	13	12	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:46443289G>T	ENST00000263257.5	-	4	1505	c.1311C>A	c.(1309-1311)ggC>ggA	p.G437G		NM_002516.2	NP_002507.1	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	437	KH 3.					nucleus	RNA binding	p.G437G(1)		endometrium(3)|large_intestine(5)|lung(13)	21		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		GGATGCGAGCGCCCGTCAGCT	0.662													41	159					3.76604e-16	4.27842e-16	1	1	0	T	46443289	G	T	46443289	2	4	30	1	0	0	0	0	0	0	0	1	10601	1074	38	5		5	NOVA2	19	46443289	Silent	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08	30453118	46443289	12685694	118	2935										
PPP2R1A	5518	broad.mit.edu	37	chr19	52716323	52716323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ccaggccgctgaagacaagtCctggcgcgtccgctacatgg	13	14	0	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:52716323C>T	ENST00000322088.6	+	6	825	c.767C>T	c.(766-768)tCc>tTc	p.S256F	PPP2R1A_ENST00000462990.1_Missense_Mutation_p.S77F|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S201F	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	256	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.S256F(11)|p.S256Y(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GAAGACAAGTCCTGGCGCGTC	0.617			Mis		clear cell ovarian carcinoma								13	38					0	0	1	0	0	T	52716323	C	T	52716323	3	4	30	1	0	0	0	0	1	0	0	0	12430	855	30	3	789	3	PPP2R1A	19	52716323	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	6273034	52716323	6412660	119	2936										
LILRB5	0	broad.mit.edu	37	chr19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggaacgtggtgggggtggggAggcctgggggcctggagagg	26	5	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607													5	52					0	0	1	0	0	G	54754843	A	G	54754843	3	3	30	1	0	0	0	0	1	0	0	0	8833	319	11	4		4	LILRB5	19	54754843	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	2038520	54754843	4374140	120	2937										
ZFP28	140612	broad.mit.edu	37	chr19	57065752	57065752	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tcatactggagagaaaccttAcaaatgtgatgtatgtcaca	8	7	2	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr19:57065752A>T	ENST00000301318.3	+	8	1669	c.1598A>T	c.(1597-1599)tAc>tTc	p.Y533F	AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GAGAAACCTTACAAATGTGAT	0.418													5	41					0	0	1	0	0	T	57065752	A	T	57065752	3	4	30	1	0	0	0	0	1	0	0	0	17699	391	14	4	1628	4	ZFP28	19	57065752	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	2310909	57065752	2063231	121	2938										
UQCC	0	broad.mit.edu	37	chr20	33971845	33971845	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cactgataattctcaccttaCgtgtggtgtgatacttccta	7	10	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr20:33971845C>T	ENST00000397554.1	-	3	231	c.221G>A	c.(220-222)cGt>cAt	p.R74H	UQCC_ENST00000397556.3_Intron|UQCC_ENST00000374384.2_Missense_Mutation_p.R74H|UQCC_ENST00000359226.2_Missense_Mutation_p.R74H|UQCC_ENST00000349714.5_Missense_Mutation_p.R74H|UQCC_ENST00000542501.1_Missense_Mutation_p.R74H|UQCC_ENST00000374385.5_Missense_Mutation_p.R74H|UQCC_ENST00000407996.2_Splice_Site|UQCC_ENST00000374380.2_Intron|UQCC_ENST00000491125.1_5'UTR|UQCC_ENST00000540457.1_Intron|UQCC_ENST00000374377.5_Intron			Q9NVA1	UQCC_HUMAN		74						cytoplasmic membrane-bounded vesicle				breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TCTCACCTTACGTGTGGTGTG	0.433													8	24					0	0	1	0	0	T	33971845	C	T	33971845	3	4	30	1	0	0	0	0	1	0	0	0	17074	536	19	1	710	1	UQCC	20	33971845	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08		33971845	29053675	122	2939										
TSHZ2	128553	broad.mit.edu	37	chr20	51871857	51871857	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgtgggaaagaaagtccccaCgaagaggcctcatctttcag	11	10	3	2	rs143642849		TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr20:51871857C>G	ENST00000371497.5	+	2	2747	c.1860C>G	c.(1858-1860)caC>caG	p.H620Q	TSHZ2_ENST00000603338.2_Missense_Mutation_p.H617Q|TSHZ2_ENST00000329613.6_Missense_Mutation_p.H617Q	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	620					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AAAGTCCCCACGAAGAGGCCT	0.517													35	113					0	0	1	0	0	G	51871857	C	G	51871857	3	3	30	1	0	0	0	0	1	0	0	0	16684	535	19	5	1866	5	TSHZ2	20	51871857	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08	17900012	51871857	11153663	123	2940										
SON	6651	broad.mit.edu	37	chr21	34926321	34926321	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	tgcaggagaaactctatcttCtactggtccttttgctctgg	9	10	4	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr21:34926321C>T	ENST00000356577.4	+	3	5259	c.4784C>T	c.(4783-4785)tCt>tTt	p.S1595F	SON_ENST00000381692.2_Intron|SON_ENST00000290239.6_Missense_Mutation_p.S1595F|SON_ENST00000381679.4_Missense_Mutation_p.S1595F|SON_ENST00000300278.4_Missense_Mutation_p.S1595F	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1595					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						ACTCTATCTTCTACTGGTCCT	0.413													26	64					0	0	1	0	0	T	34926321	C	T	34926321	3	4	30	1	0	0	0	0	1	0	0	0	14979	913	32	3	4794	3	SON	21	34926321	Missense_Mutation	SNP	C	TCGA-N8-A4PP-01A-11D-A28R-08		34926321	13203574	124	2941										
PIWIL3	440822	broad.mit.edu	37	chr22	25153946	25153946	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	ggtcttgaaaaactccaccaAtccttctctcctgcaagggc	7	14	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr22:25153946A>G	ENST00000332271.5	-	4	700	c.284T>C	c.(283-285)aTt>aCt	p.I95T	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_5'UTR|PIWIL3_ENST00000533313.1_5'UTR	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	95					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AACTCCACCAATCCTTCTCTC	0.438													86	155					0	0	1	0	0	G	25153946	A	G	25153946	3	3	30	1	0	0	0	0	1	0	0	0	12006	101	4	4	2436	4	PIWIL3	22	25153946	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08		25153946	26150620	125	2942										
XPNPEP3	63929	broad.mit.edu	37	chr22	41320470	41320470	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	cctctgcagcctgggatggtAatcacaattgagcccggtaa	11	11	2	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chr22:41320470A>C	ENST00000357137.4	+	9	1425	c.1341A>C	c.(1339-1341)gtA>gtC	p.V447V	XPNPEP3_ENST00000544094.1_Silent_p.V424V	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	447					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						CTGGGATGGTAATCACAATTG	0.473													9	31					0	0	1	0	0	C	41320470	A	C	41320470	2	2	30	1	0	0	0	0	0	0	0	1	17503	349	13	4		4	XPNPEP3	22	41320470	Silent	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	16166524	41320470	9984096	126	2943										
TLR7	51284	broad.mit.edu	37	chrX	12903969	12903969	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aaaaacaacatgtgcatcaaGaggctgcagattaaacccag	8	9	1	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chrX:12903969G>T	ENST00000380659.3	+	3	481	c.342G>T	c.(340-342)aaG>aaT	p.K114N		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	114					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	TGTGCATCAAGAGGCTGCAGA	0.478													39	80					9.62906e-15	1.07923e-14	1	1	0	T	12903969	G	T	12903969	3	4	30	1	0	0	0	0	1	0	0	0	16015	933	33	2	348	2	TLR7	23	12903969	Missense_Mutation	SNP	G	TCGA-N8-A4PP-01A-11D-A28R-08		12903969	142366591	127	2944										
PHKA2	5256	broad.mit.edu	37	chrX	18972448	18972448	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	aggccatgcccaggccccacAcggccaggatactgtagatg	12	14	0	1			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chrX:18972448A>C	ENST00000379942.4	-	2	826	c.161T>G	c.(160-162)gTg>gGg	p.V54G		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	54					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					CAGGCCCCACACGGCCAGGAT	0.567													27	47					0	0	1	0	0	C	18972448	A	C	18972448	3	2	30	1	0	0	0	0	1	0	0	0	11891	159	6	4	3674	4	PHKA2	23	18972448	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	6068479	18972448	136298112	128	2945										
NSDHL	50814	broad.mit.edu	37	chrX	152037350	152037350	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0697674418604651	9	1	1.11684782608696	2.15276465028355	0.416080562659847	0.117538005190953	0.651583710407241	0	atttcacatcaccaatgatgAgcccatccctttctggacat	5	13	3	2			TCGA-N8-A4PP-01A-11D-A28R-08	TCGA-N8-A4PP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e6eb56d-1825-41f7-93fe-665c0bac1c15	db457003-170c-4835-8f37-a73bb4da8189	g.chrX:152037350A>C	ENST00000370274.3	+	8	1006	c.812A>C	c.(811-813)gAg>gCg	p.E271A	NSDHL_ENST00000440023.1_Missense_Mutation_p.E271A	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	271					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	ACCAATGATGAGCCCATCCCT	0.532													22	217					0	0	1	0	0	C	152037350	A	C	152037350	3	2	30	1	0	0	0	0	1	0	0	0	10717	304	11	4	838	4	NSDHL	23	152037350	Missense_Mutation	SNP	A	TCGA-N8-A4PP-01A-11D-A28R-08	133064902	152037350	3233210	129	2946										
MEGF6	1953	broad.mit.edu	37	chr1	3418372	3418372	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	acactcacctgcctcacagtCttccccagtcctccccggcg	6	21	3	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:3418372C>A	ENST00000356575.4	-	18	2528	c.2302G>T	c.(2302-2304)Gac>Tac	p.D768Y	MEGF6_ENST00000294599.4_Missense_Mutation_p.D663Y	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	768	EGF-like 12.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCTCACAGTCTTCCCCAGTC	0.711													12	22					6.40141e-05	6.90348e-05	1	1	0	A	3418372	C	A	3418372	3	1	31	1	0	0	0	0	1	0	0	0	9511	913	32	2	2403	2	MEGF6	1	3418372	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		3418372	245832249	1	2947										
RAB42	115273	broad.mit.edu	37	chr1	28920318	28920318	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ggcaccaggaggtcatggccActcagggcccggacaaggtc	15	13	2	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:28920318A>T	ENST00000373826.3	+	2	313	c.7A>T	c.(7-9)Act>Tct	p.T3S	TAF12_ENST00000471683.1_Intron|RAB42_ENST00000465518.1_3'UTR	NM_152304.1	NP_689517.1	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	3					small GTPase mediated signal transduction	membrane	GTP binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCATGGCCACTCAGGGCCC	0.577													7	6					0	0	1	0	0	T	28920318	A	T	28920318	3	4	31	1	0	0	0	0	1	0	0	0	12995	159	6	4	9	4	RAB42	1	28920318	Missense_Mutation	SNP	A	TCGA-N8-A4PQ-01A-11D-A28R-08	25501946	28920318	220330303	2	2948										
TMEM125	128218	broad.mit.edu	37	chr1	43738488	43738488	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gtggtggtcccagcagccgcGgcgctcggcgctctgcttcg	16	15	1	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:43738488G>A	ENST00000432792.2	+	4	665	c.95G>A	c.(94-96)cGg>cAg	p.R32Q	TMEM125_ENST00000439858.1_Missense_Mutation_p.R32Q			Q96AQ2	TM125_HUMAN	transmembrane protein 125	32						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAGCAGCCGCGGCGCTCGGCG	0.711													3	13					0	0	1	0	0	A	43738488	G	A	43738488	3	1	31	1	0	0	0	0	1	0	0	0	16096	1116	39	1	97	1	TMEM125	1	43738488	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	14818170	43738488	205512133	3	2949										
C1orf177	163747	broad.mit.edu	37	chr1	55277787	55277787	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	acatatgtggcacgatccgtCggcacccgcggcccctatga	11	15	0	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:55277787C>A	ENST00000358193.3	+	6	741	c.687C>A	c.(685-687)gtC>gtA	p.V229V	C1orf177_ENST00000371273.3_Silent_p.V229V	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	229										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CACGATCCGTCGGCACCCGCG	0.587													20	67					5.03518e-11	5.76948e-11	1	1	0	A	55277787	C	A	55277787	2	1	31	1	0	0	0	0	0	0	0	1	2030	871	31	2		2	C1orf177	1	55277787	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	11539299	55277787	193972834	4	2950										
CD1D	912	broad.mit.edu	37	chr1	158152703	158152703	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ggctgtcccgtggccccagtCctggccctggccgtctgctg	14	17	1	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:158152703C>A	ENST00000368171.3	+	5	1142	c.643C>A	c.(643-645)Cct>Act	p.P215T		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	215	Ig-like.				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TGGCCCCAGTCCTGGCCCTGG	0.592													20	65					1.01871e-10	1.15524e-10	1	1	0	A	158152703	C	A	158152703	3	1	31	1	0	0	0	0	1	0	0	0	2999	855	30	2	657	2	CD1D	1	158152703	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	102874916	158152703	91097918	5	2951										
OR10J5	127385	broad.mit.edu	37	chr1	159505384	159505384	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	accagctgggcacatagtccCttgctcatgatgacagtgta	10	11	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:159505384C>T	ENST00000334857.2	-	1	458	c.414G>A	c.(412-414)aaG>aaA	p.K138K		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					CACATAGTCCCTTGCTCATGA	0.502													4	85					0	0	1	0	0	T	159505384	C	T	159505384	2	4	31	1	0	0	0	0	0	0	0	1	10959	680	24	3		3	OR10J5	1	159505384	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	1352681	159505384	89745237	6	2952										
CD34	947	broad.mit.edu	37	chr1	208070903	208070903	+	Frame_Shift_Del	DEL	A	A	-													0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tttcacttctctgatgcctgAacatttgatttctgcctgta							TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:208070903delA	ENST00000356522.4	-	4	853	c.532delT	c.(532-534)cafs	p.S178fs	CD34_ENST00000310833.7_Frame_Shift_Del_p.S178fs|CD34_ENST00000537704.1_Frame_Shift_Del_p.S43fs|CD34_ENST00000485761.1_5'UTR	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	178					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						CTGATGCCTGAACATTTGATT	0.418													2	4	---	---	---	---						-	208070903	A	-	208070903	7	5	31	1	0	1	0	1	0	0	0	0	3028	246	9	0	664	0	CD34	1	208070903	Frame_Shift_Del	DEL	A	TCGA-N8-A4PQ-01A-11D-A28R-08	48565519	208070903	41179718	7	2953										
MTR	4548	broad.mit.edu	37	chr1	237016332	237016332	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	aacttctgcagctctgtgaaGatctcatctggaataaagac	8	9	4	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr1:237016332G>T	ENST00000366577.5	+	18	2291	c.1897G>T	c.(1897-1899)Gat>Tat	p.D633Y	MTR_ENST00000535889.1_Missense_Mutation_p.D633Y	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	633					nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GCTCTGTGAAGATCTCATCTG	0.438													14	46					0.000219431	0.000232091	1	1	0	T	237016332	G	T	237016332	3	4	31	1	0	0	0	0	1	0	0	0	10005	942	33	2	1967	2	MTR	1	237016332	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	28945429	237016332	12234289	8	2954										
FAM49A	81553	broad.mit.edu	37	chr2	16742751	16742751	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ttgttgatgcggttgcgactGattgttcttctgtagtagct	12	6	2	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:16742751G>T	ENST00000381323.3	-	7	706	c.486C>A	c.(484-486)atC>atA	p.I162I	FAM49A_ENST00000406434.1_Silent_p.I162I|FAM49A_ENST00000355549.2_Silent_p.I162I	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	162						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			GGTTGCGACTGATTGTTCTTC	0.493													9	42					0.000978159	0.00100558	1	1	0	T	16742751	G	T	16742751	2	4	31	1	0	0	0	0	0	0	0	1	5610	1280	45	2		2	FAM49A	2	16742751	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		16742751	226456622	9	2955										
RDH14	57665	broad.mit.edu	37	chr2	18736500	18736500	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cttcactgatatcccagagtTttcttgcaacagattcatcc	5	12	3	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:18736500T>G	ENST00000381249.3	-	2	1075	c.968A>C	c.(967-969)aAa>aCa	p.K323T	RDH14_ENST00000468071.1_5'UTR	NM_020905.3	NP_065956.1			retinol dehydrogenase 14 (all-trans/9-cis/11-cis)											breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)					ATCCCAGAGTTTTCTTGCAAC	0.413													33	71					0	0	1	0	0	G	18736500	T	G	18736500	3	3	31	1	0	0	0	0	1	0	0	0	13244	1841	64	4	46	4	RDH14	2	18736500	Missense_Mutation	SNP	T	TCGA-N8-A4PQ-01A-11D-A28R-08	1993749	18736500	224462873	10	2956										
WDR43	23160	broad.mit.edu	37	chr2	29158461	29158461	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cccctgcatactattattccGttgttacaagaggtaactga	7	10	0	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:29158461G>A	ENST00000407426.3	+	12	1568	c.1512G>A	c.(1510-1512)ccG>ccA	p.P504P		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	504						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					CTATTATTCCGTTGTTACAAG	0.323													12	31					0	0	1	0	0	A	29158461	G	A	29158461	2	1	31	1	0	0	0	0	0	0	0	1	17354	1132	40	1		1	WDR43	2	29158461	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	10421961	29158461	214040912	11	2957										
DYSF	8291	broad.mit.edu	37	chr2	71780304	71780304	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ctccaccactcagtacagccGtgcagtctttgacggtgagg	11	13	2	2	rs150417363		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr2:71780304G>C	ENST00000258104.3	+	20	2193	c.1916G>C	c.(1915-1917)cGt>cCt	p.R639P	DYSF_ENST00000394120.2_Missense_Mutation_p.R640P|DYSF_ENST00000409366.1_Missense_Mutation_p.R640P|DYSF_ENST00000429174.2_Missense_Mutation_p.R639P|DYSF_ENST00000409744.1_Missense_Mutation_p.R626P|DYSF_ENST00000413539.2_Missense_Mutation_p.R670P|DYSF_ENST00000410020.3_Missense_Mutation_p.R657P|DYSF_ENST00000409762.1_Missense_Mutation_p.R656P|DYSF_ENST00000410041.1_Missense_Mutation_p.R657P|DYSF_ENST00000409582.3_Missense_Mutation_p.R656P|DYSF_ENST00000409651.1_Missense_Mutation_p.R671P	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	639						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CAGTACAGCCGTGCAGTCTTT	0.582													10	113					0	0	1	0	0	C	71780304	G	C	71780304	3	2	31	1	0	0	0	0	1	0	0	0	4885	1145	40	5	2186	5	DYSF	2	71780304	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	42621843	71780304	171419069	12	2958										
CNTN4	152330	broad.mit.edu	37	chr3	3076369	3076369	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	acgaaatcacagataccactGctcagctctcctggagaccc	7	15	3	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:3076369G>A	ENST00000397461.1	+	16	2221	c.1837G>A	c.(1837-1839)Gct>Act	p.A613T	CNTN4_ENST00000427331.1_Missense_Mutation_p.A613T|CNTN4_ENST00000418658.1_Missense_Mutation_p.A613T|CNTN4_ENST00000397459.2_Missense_Mutation_p.A285T|CNTN4_ENST00000448906.2_Missense_Mutation_p.A285T|CNTN4_ENST00000358480.3_Missense_Mutation_p.A394T	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	613	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGATACCACTGCTCAGCTCTC	0.552													25	38					0	0	1	0	0	A	3076369	G	A	3076369	3	1	31	1	0	0	0	0	1	0	0	0	3666	1319	46	3	1891	3	CNTN4	3	3076369	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		3076369	194946061	13	2959										
CNTN3	5067	broad.mit.edu	37	chr3	74411041	74411041	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ttttctggacatcaaaatacCtttcatgctcctgcacgctc	5	13	3	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr3:74411041C>T	ENST00000263665.6	-	10	1391	c.1364_splice	c.e10+1	p.R455_splice		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	455	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ATCAAAATACCTTTCATGCTC	0.448													27	21					0	0	1	0	0	T	74411041	C	T	74411041	5	4	31	1	0	0	0	0	0	0	1	0	3665	695	24	3	1774	3	CNTN3	3	74411041	Splice_Site	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	71334672	74411041	123611389	14	2960										
UGDH	7358	broad.mit.edu	37	chr4	39506922	39506922	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tttgttccctaggtacttttGgatcatatatatgtagatgt	8	5	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:39506922G>C	ENST00000316423.6	-	9	1448	c.1106C>G	c.(1105-1107)cCa>cGa	p.P369R	UGDH_ENST00000507089.1_Missense_Mutation_p.P272R|UGDH_ENST00000506179.1_Missense_Mutation_p.P369R|UGDH_ENST00000501493.2_Missense_Mutation_p.P302R	NM_001184701.1|NM_003359.3	NP_001171630.1|NP_003350.1	O60701	UGDH_HUMAN	UDP-glucose 6-dehydrogenase	369					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			breast(1)|central_nervous_system(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(2)	27					NADH(DB00157)	AGGTACTTTTGGATCATATAT	0.348													11	37					0	0	1	0	0	C	39506922	G	C	39506922	3	2	31	1	0	0	0	0	1	0	0	0	16999	1348	47	5	394	5	UGDH	4	39506922	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		39506922	151647354	15	2961										
GRXCR1	389207	broad.mit.edu	37	chr4	42895339	42895339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gccacggaaagtccggtttcGgatcgcgtcctctcacagtg	12	13	1	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:42895339G>A	ENST00000399770.2	+	1	56	c.56G>A	c.(55-57)cGg>cAg	p.R19Q		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	19					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						GTCCGGTTTCGGATCGCGTCC	0.512													19	105					0	0	1	0	0	A	42895339	G	A	42895339	3	1	31	1	0	0	0	0	1	0	0	0	6852	1116	39	1	58	1	GRXCR1	4	42895339	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	3388417	42895339	148258937	16	2962										
KIAA1211	57482	broad.mit.edu	37	chr4	57193840	57193840	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cgactcggctcccccagcgcCgctggtaaaagaagtcacca	10	16	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:57193840C>T	ENST00000504228.1	+	9	3677	c.3572C>T	c.(3571-3573)cCg>cTg	p.P1191L	KIAA1211_ENST00000541073.1_Missense_Mutation_p.P1184L|KIAA1211_ENST00000264229.6_Missense_Mutation_p.P1191L			Q6ZU35	K1211_HUMAN	KIAA1211	1191										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CCCCCAGCGCCGCTGGTAAAA	0.483													61	76					0	0	1	0	0	T	57193840	C	T	57193840	3	4	31	1	0	0	0	0	1	0	0	0	8256	652	23	1	3602	1	KIAA1211	4	57193840	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	14298501	57193840	133960436	17	2963										
SRP72	6731	broad.mit.edu	37	chr4	57333819	57333820	+	Frame_Shift_Ins	INS	-	-	G													0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	agatggcgagcggcggcagcINSgggggggtgtcagtacctgc					rs17524437	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:57333819_57333820insG	ENST00000342756.5	+	1	739_740	c.18_19insG	c.(16-21)agggggfs	p.RG6fs	SRP72_ENST00000504757.1_Frame_Shift_Ins_p.RG6fs|SRP72_ENST00000510663.1_Frame_Shift_Ins_p.RG6fs	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	6					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					GCGGCGGCAGCGGGGGGGTGTC	0.639													10	21	---	---	---	---						G	57333820	-	G	57333819	7	5	31	1	0	1	1	0	0	0	0	0	15212	767	27	0	20	0	SRP72	4	57333819	Frame_Shift_Ins	INS	-	TCGA-N8-A4PQ-01A-11D-A28R-08	139979	57333819	133820457	18	2964										
ANXA10	11199	broad.mit.edu	37	chr4	169049237	169049237	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cattgattttcccaccaggtGcaaggaaccatcttcccagc	7	14	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr4:169049237G>A	ENST00000359299.3	+	2	207	c.21G>A	c.(19-21)gtG>gtA	p.V7V		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	7							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		CCCACCAGGTGCAAGGAACCA	0.433													10	15					0	0	1	0	0	A	169049237	G	A	169049237	2	1	31	1	0	0	0	0	0	0	0	1	709	1306	46	3		3	ANXA10	4	169049237	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	111715418	169049237	22105039	19	2965										
TAS2R1	50834	broad.mit.edu	37	chr5	9630016	9630016	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	caagaaagaaggagatccagCggagccatttttctgtgctt	11	8	1	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:9630016C>T	ENST00000382492.2	-	1	447	c.129G>A	c.(127-129)ccG>ccA	p.P43P	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	43					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						GGAGATCCAGCGGAGCCATTT	0.378													8	72					0	0	1	0	0	T	9630016	C	T	9630016	2	4	31	1	0	0	0	0	0	0	0	1	15621	755	27	1		1	TAS2R1	5	9630016	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		9630016	171285244	20	2966										
CDH9	1007	broad.mit.edu	37	chr5	26886102	26886102	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	atctacaatggtgaaattcgGattgagagtaaattctggca	10	5	2	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:26886102G>C	ENST00000231021.4	-	10	1775	c.1603C>G	c.(1603-1605)Ccg>Gcg	p.P535A		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	535	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P535T(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GTGAAATTCGGATTGAGAGTA	0.318													4	94					0	0	1	0	0	C	26886102	G	C	26886102	3	2	31	1	0	0	0	0	1	0	0	0	3139	1174	41	2	778	2	CDH9	5	26886102	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	17256086	26886102	154029158	21	2967										
NDUFAF2	91942	broad.mit.edu	37	chr5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ttacccctactgcgggtcccGctgctggcagcgctggaaac	12	15	0	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632													3	15					0	0	1	0	0	A	60241050	G	A	60241050	1	1	31	1	0	0	0	0	0	0	0	0	10321	1102	38	1		1	NDUFAF2	5	60241050	Translation_Start_Site	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	33354948	60241050	120674210	22	2968										
LNPEP	4012	broad.mit.edu	37	chr5	96360368	96360368	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	agcacttgccagctcagaggAtgtgcggaagctttactggt	13	9	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:96360368A>G	ENST00000231368.5	+	15	3397	c.2705A>G	c.(2704-2706)gAt>gGt	p.D902G	LNPEP_ENST00000395770.3_Missense_Mutation_p.D888G	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	902					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		AGCTCAGAGGATGTGCGGAAG	0.408													11	20					0	0	1	0	0	G	96360368	A	G	96360368	3	3	31	1	0	0	0	0	1	0	0	0	8904	333	12	4	2763	4	LNPEP	5	96360368	Missense_Mutation	SNP	A	TCGA-N8-A4PQ-01A-11D-A28R-08	36119318	96360368	84554892	23	2969										
MATR3	9782	broad.mit.edu	37	chr5	138643467	138643467	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tttggtctgtctgctagagaCttagatgaactgagtcgtta	11	6	2	4			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:138643467C>G	ENST00000394800.2	+	6	912	c.363C>G	c.(361-363)gaC>gaG	p.D121E	MATR3_ENST00000361059.2_Missense_Mutation_p.D121E|MATR3_ENST00000503811.1_Intron|MATR3_ENST00000510056.1_Missense_Mutation_p.D121E|MATR3_ENST00000509990.1_Missense_Mutation_p.D121E|MATR3_ENST00000394805.3_Missense_Mutation_p.D121E|MATR3_ENST00000502499.1_Intron|MATR3_ENST00000502929.1_Missense_Mutation_p.D121E|MATR3_ENST00000504203.1_Intron			P43243	MATR3_HUMAN	matrin 3	121						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CTGCTAGAGACTTAGATGAAC	0.463													9	52					0	0	1	0	0	G	138643467	C	G	138643467	3	3	31	1	0	0	0	0	1	0	0	0	9386	564	20	5	365	5	MATR3	5	138643467	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	42283099	138643467	42271793	24	2970										
GABRA1	2554	broad.mit.edu	37	chr5	161318010	161318010	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	acagtgattctctcacaagtCtccttctggctcaacagaga	7	12	5	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr5:161318010C>G	ENST00000428797.2	+	9	1165	c.810C>G	c.(808-810)gtC>gtG	p.V270V	GABRA1_ENST00000023897.6_Silent_p.V270V|GABRA1_ENST00000437025.2_Silent_p.V270V|GABRA1_ENST00000420560.1_Silent_p.V270V|GABRA1_ENST00000444819.1_Silent_p.V270V|GABRA1_ENST00000393943.4_Silent_p.V270V	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	270					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TCTCACAAGTCTCCTTCTGGC	0.408													61	10					0	0	1	0	0	G	161318010	C	G	161318010	2	3	31	1	0	0	0	0	0	0	0	1	6194	900	32	2		2	GABRA1	5	161318010	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	22674543	161318010	19597250	25	2971										
SERPINB9	5272	broad.mit.edu	37	chr6	2893765	2893765	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tctgcatcaattgagctaccCggcaacaactcttcaatttt	5	12	4	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:2893765C>T	ENST00000380698.4	-	5	536	c.447G>A	c.(445-447)ccG>ccA	p.P149P		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	149					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TTGAGCTACCCGGCAACAACT	0.393													39	13					0	0	1	0	0	T	2893765	C	T	2893765	2	4	31	1	0	0	0	0	0	0	0	1	14161	639	23	1		1	SERPINB9	6	2893765	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		2893765	168221302	26	2972										
BTNL2	56244	broad.mit.edu	37	chr6	32362585	32362585	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	atgctgatggaacaagtgacGtccacagcggagatgtttgt	13	7	0	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:32362585G>T	ENST00000454136.3	-	6	1300	c.1296C>A	c.(1294-1296)gaC>gaA	p.D432E	BTNL2_ENST00000374993.1_Missense_Mutation_p.D432E|BTNL2_ENST00000414363.1_Missense_Mutation_p.D222E|BTNL2_ENST00000429232.2_3'UTR|BTNL2_ENST00000544175.1_Missense_Mutation_p.D155E|BTNL2_ENST00000540315.1_Missense_Mutation_p.D222E|BTNL2_ENST00000374995.3_Missense_Mutation_p.D338E			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	432						integral to membrane		p.D432D(1)		central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						AACAAGTGACGTCCACAGCGG	0.498													14	78					7.93312e-07	8.81458e-07	1	1	0	T	32362585	G	T	32362585	3	4	31	1	0	0	0	0	1	0	0	0	1568	1136	40	5	75	5	BTNL2	6	32362585	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	29468820	32362585	138752482	27	2973										
RUNX2	860	broad.mit.edu	37	chr6	45390466	45390466	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cagcagcagcagcagcagcaAcagcagcagcagcagcagga	13	13	0	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:45390466A>G	ENST00000371438.1	+	2	553	c.195A>G	c.(193-195)caA>caG	p.Q65Q	RUNX2_ENST00000352853.5_Silent_p.Q133Q|RUNX2_ENST00000541979.1_Silent_p.Q133Q|RUNX2_ENST00000465038.2_Silent_p.Q65Q|RUNX2_ENST00000576263.1_Silent_p.Q65Q|RUNX2_ENST00000371432.3_Silent_p.Q51Q|RUNX2_ENST00000371436.6_Silent_p.Q65Q|RUNX2_ENST00000359524.5_Silent_p.Q51Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	65	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcagcaacagcagcagc	0.731													3	36					0	0	1	0	0	G	45390466	A	G	45390466	2	3	31	1	0	0	0	0	0	0	0	1	13799	40	2	4		4	RUNX2	6	45390466	Silent	SNP	A	TCGA-N8-A4PQ-01A-11D-A28R-08	13027881	45390466	125724601	28	2974										
HIVEP2	3097	broad.mit.edu	37	chr6	143091566	143091566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gagaaagcattcgcttgctaCctcccagggtggccacgctg	12	13	0	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr6:143091566C>T	ENST00000367603.2	-	5	5052	c.4310G>A	c.(4309-4311)gGt>gAt	p.G1437D	HIVEP2_ENST00000367604.1_Missense_Mutation_p.G1437D|HIVEP2_ENST00000012134.2_Missense_Mutation_p.G1437D	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCGCTTGCTACCTCCCAGGGT	0.512													26	33					0	0	1	0	0	T	143091566	C	T	143091566	3	4	31	1	0	0	0	0	1	0	0	0	7227	507	18	3	3054	3	HIVEP2	6	143091566	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	97701100	143091566	28023501	29	2975										
USP42	84132	broad.mit.edu	37	chr7	6175578	6175578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	atgtttgtcatcaatgagatGcggcgtaagtattaactatt	9	5	2	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:6175578G>A	ENST00000306177.5	+	4	707	c.549G>A	c.(547-549)atG>atA	p.M183I		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	183					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		TCAATGAGATGCGGCGTAAGT	0.348													8	12					0	0	1	0	0	A	6175578	G	A	6175578	3	1	31	1	0	0	0	0	1	0	0	0	17132	1319	46	3	559	3	USP42	7	6175578	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		6175578	152963085	30	2976										
KDELR2	0	broad.mit.edu	37	chr7	6509337	6509337	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	atcgtaggttgccttaaattTcaggtagatcaggtacactg	10	7	2	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:6509337T>G	ENST00000258739.4	-	3	425	c.241A>C	c.(241-243)Aaa>Caa	p.K81Q	KDELR2_ENST00000490996.1_Missense_Mutation_p.K81Q|DAGLB_ENST00000436575.1_Intron|KDELR2_ENST00000463747.1_Intron	NM_006854.3	NP_006845.1	P33947	ERD22_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	81					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GCCTTAAATTTCAGGTAGATC	0.443													21	66					0	0	1	0	0	G	6509337	T	G	6509337	3	3	31	1	0	0	0	0	1	0	0	0	8163	1792	62	4	584	4	KDELR2	7	6509337	Missense_Mutation	SNP	T	TCGA-N8-A4PQ-01A-11D-A28R-08	333759	6509337	152629326	31	2977										
FZD1	8321	broad.mit.edu	37	chr7	90895680	90895680	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ggcttcgtgctggcgcccctCttcgtgtacctgtttatcgg	12	13	1	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:90895680C>G	ENST00000287934.2	+	1	1898	c.1485C>G	c.(1483-1485)ctC>ctG	p.L495L		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	495					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGGCGCCCCTCTTCGTGTACC	0.622													74	100					0	0	1	0	0	G	90895680	C	G	90895680	2	3	31	1	0	0	0	0	0	0	0	1	6162	900	32	2		2	FZD1	7	90895680	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	84386343	90895680	68242983	32	2978										
CPA4	51200	broad.mit.edu	37	chr7	129950692	129950692	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cccacgccaattcggaagtgGaggtgaaatcagtggtagat	13	8	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr7:129950692G>C	ENST00000222482.4	+	9	887	c.859G>C	c.(859-861)Gag>Cag	p.E287Q	CPA4_ENST00000493259.1_Missense_Mutation_p.E183Q|CPA4_ENST00000445470.2_Missense_Mutation_p.E254Q	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	287					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					TTCGGAAGTGGAGGTGAAATC	0.493													26	71					0	0	1	0	0	C	129950692	G	C	129950692	3	2	31	1	0	0	0	0	1	0	0	0	3815	1175	41	2	893	2	CPA4	7	129950692	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	39055012	129950692	29187971	33	2979										
TRHR	7201	broad.mit.edu	37	chr8	110131681	110131681	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gaggtatcctttagccaaagTtgattcatgaattagaagaa	9	5	1	4			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr8:110131681T>A	ENST00000518632.1	+	3	1545	c.1194T>A	c.(1192-1194)agT>agA	p.S398R	TRHR_ENST00000311762.2_Missense_Mutation_p.S398R			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	398						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TTAGCCAAAGTTGATTCATGA	0.403													12	80					0	0	1	0	0	A	110131681	T	A	110131681	3	1	31	1	0	0	0	0	1	0	0	0	16540	1722	60	4	1200	4	TRHR	8	110131681	Missense_Mutation	SNP	T	TCGA-N8-A4PQ-01A-11D-A28R-08		110131681	36232341	34	2980										
CYP11B2	1585	broad.mit.edu	37	chr8	143996607	143996607	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	aacctctgcacggccttgggCgacagcacatctgggttcag	12	13	3	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr8:143996607C>A	ENST00000323110.2	-	3	452	c.450G>T	c.(448-450)tcG>tcT	p.S150S		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	150					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CGGCCTTGGGCGACAGCACAT	0.637									Familial Hyperaldosteronism type I				7	71					8.12818e-05	8.68059e-05	1	1	0	A	143996607	C	A	143996607	2	1	31	1	0	0	0	0	0	0	0	1	4169	755	27	5		5	CYP11B2	8	143996607	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	33864926	143996607	2367415	35	2981										
PTPRD	5789	broad.mit.edu	37	chr9	8331734	8331734	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cttactgttcgggactggccGtcctttagaaggaaagccac	11	11	0	1	rs143526425	byFrequency	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:8331734G>A	ENST00000381196.4	-	41	5925	c.5382C>T	c.(5380-5382)gaC>gaT	p.D1794D	PTPRD_ENST00000355233.5_Silent_p.D1388D|PTPRD_ENST00000397606.3_Silent_p.D1387D|PTPRD_ENST00000537002.1_Silent_p.D1384D|PTPRD_ENST00000397611.3_Silent_p.D1384D|PTPRD_ENST00000358503.5_Silent_p.D1772D|PTPRD_ENST00000540109.1_Silent_p.D1794D|PTPRD_ENST00000360074.4_Silent_p.D1781D|PTPRD_ENST00000397617.3_Silent_p.D1387D|PTPRD_ENST00000486161.1_Silent_p.D1387D|PTPRD_ENST00000356435.5_Silent_p.D1794D	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1794	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGGACTGGCCGTCCTTTAGAA	0.512										TSP Lung(15;0.13)			13	32					0	0	1	0	0	A	8331734	G	A	8331734	2	1	31	1	0	0	0	0	0	0	0	1	12850	1136	40	1		1	PTPRD	9	8331734	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		8331734	132881697	36	2982										
KIAA1045	23349	broad.mit.edu	37	chr9	34978096	34978096	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	agcgcagccattcacctgaaGcccccaggatagcatggagc	11	14	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr9:34978096G>A	ENST00000242315.3	+	8	1273	c.1191G>A	c.(1189-1191)aaG>aaA	p.K397K	KIAA1045_ENST00000476115.2_3'UTR|KIAA1045_ENST00000544237.1_Silent_p.K397K	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	397							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			TTCACCTGAAGCCCCCAGGAT	0.557													14	78					0	0	1	0	0	A	34978096	G	A	34978096	2	1	31	1	0	0	0	0	0	0	0	1	8248	962	34	3		3	KIAA1045	9	34978096	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	26646362	34978096	106235335	37	2983										
LARP4B	23185	broad.mit.edu	37	chr10	909780	909780	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tcctgcgggtctggcaatgcGgcattctcatggccctggtc	13	13	2	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:909780G>A	ENST00000316157.3	-	4	373	c.333C>T	c.(331-333)gcC>gcT	p.A111A		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	111							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						CTGGCAATGCGGCATTCTCAT	0.507													49	48					0	0	1	0	0	A	909780	G	A	909780	2	1	31	1	0	0	0	0	0	0	0	1	8669	1103	39	1		1	LARP4B	10	909780	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		909780	134624967	38	2984										
AKR1E2	83592	broad.mit.edu	37	chr10	4877922	4877922	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	actttccttctgcctctcacAtcctcgagtgcaggacttgc	7	15	2	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:4877922A>T	ENST00000298375.7	+	4	451	c.380A>T	c.(379-381)cAt>cTt	p.H127L	AKR1E2_ENST00000345253.5_Missense_Mutation_p.H127L|AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000532248.1_Missense_Mutation_p.H127L|AKR1E2_ENST00000334019.4_Missense_Mutation_p.H127L	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	127						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						TGCCTCTCACATCCTCGAGTG	0.512													4	55					0	0	1	0	0	T	4877922	A	T	4877922	3	4	31	1	0	0	0	0	1	0	0	0	471	217	8	4	394	4	AKR1E2	10	4877922	Missense_Mutation	SNP	A	TCGA-N8-A4PQ-01A-11D-A28R-08	3968142	4877922	130656825	39	2985										
MARCH8	220972	broad.mit.edu	37	chr10	45954693	45954693	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tgatcttcctgcgctcgctgGacgtcatctgcaacttctcc	8	15	4	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:45954693G>A	ENST00000453424.2	-	7	1553	c.1292C>T	c.(1291-1293)tCc>tTc	p.S431F	MARCH8_ENST00000395769.2_Missense_Mutation_p.S149F|MARCH8_ENST00000319836.3_Missense_Mutation_p.S149F|MARCH8_ENST00000395771.3_Missense_Mutation_p.S149F|MARCH8_ENST00000476962.1_5'UTR			Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	149						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						GCGCTCGCTGGACGTCATCTG	0.532													17	96					0	0	1	0	0	A	45954693	G	A	45954693	3	1	31	1	0	0	0	0	1	0	0	0	9356	1174	41	3	437	3	MARCH8	10	45954693	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	41076771	45954693	89580054	40	2986										
SYT15	83849	broad.mit.edu	37	chr10	46964009	46964009	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tggttcatcagagacactttGacaaacacacctagggaacg	9	10	2	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:46964009G>C	ENST00000374323.3	-	6	1700	c.1113C>G	c.(1111-1113)gtC>gtG	p.V371V	SYT15_ENST00000374325.3_Silent_p.V318V|RP11-38L15.3_ENST00000506914.1_RNA|SYT15_ENST00000374321.4_Silent_p.V318V|SYT15_ENST00000503753.1_Silent_p.V318V			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	318	C2 2.					integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						GAGACACTTTGACAAACACAC	0.562													19	152					0	0	1	0	0	C	46964009	G	C	46964009	2	2	31	1	0	0	0	0	0	0	0	1	15527	1277	45	2		2	SYT15	10	46964009	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	1009316	46964009	88570738	41	2987										
MKI67	4288	broad.mit.edu	37	chr10	129905829	129905829	+	Silent	SNP	T	T	C													0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ttgatgcttttatcctcaccTcctggtactttatctgtgtg							TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:129905829T>C	ENST00000368654.3	-	13	4650	c.4275A>G	c.(4273-4275)ggA>ggG	p.G1425G	MKI67_ENST00000368653.3_Silent_p.G1065G	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1425	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TATCCTCACCTCCTGGTACTT	0.483													5	241					0	0	1	0	0	C	129905829	T	C	129905829	2	2	31	1	0	0	0	0	0	0	0	1	9645	1538	54	4		4	MKI67	10	129905829	Silent	SNP	T	TCGA-N8-A4PQ-01A-11D-A28R-08	82941820	129905829	5628918	42	2988	12	2								
MKI67	4288	broad.mit.edu	37	chr10	129905831	129905831	+	Missense_Mutation	SNP	C	C	T													0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gatgcttttatcctcacctcCtggtactttatctgtgtgtg							TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:129905831C>T	ENST00000368654.3	-	13	4648	c.4273G>A	c.(4273-4275)Gga>Aga	p.G1425R	MKI67_ENST00000368653.3_Missense_Mutation_p.G1065R	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1425	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCTCACCTCCTGGTACTTTA	0.478													6	246					0	0	1	0	0	T	129905831	C	T	129905831	3	4	31	1	0	0	0	0	1	0	0	0	9645	690	24	3	5509	3	MKI67	10	129905831	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	2	129905831	5628916	43	2989	12	2								
PPP2R2D	55844	broad.mit.edu	37	chr10	133758848	133758848	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gaggagctgaccgaagtcatCactgcagccgagttccaccc	11	14	2	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr10:133758848C>A	ENST00000422256.2	+	4	509	c.24C>A	c.(22-24)atC>atA	p.I8I	PPP2R2D_ENST00000470416.1_3'UTR			Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B, delta	235	Poly-Gly.				cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			endometrium(3)|large_intestine(3)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		CCGAAGTCATCACTGCAGCCG	0.562													15	97					2.31682e-05	2.5485e-05	1	1	0	A	133758848	C	A	133758848	2	1	31	1	0	0	0	0	0	0	0	1	12435	816	29	2		2	PPP2R2D	10	133758848	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	3853017	133758848	1775899	44	2990										
OR10A6	390093	broad.mit.edu	37	chr11	7950117	7950117	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gtcaccagataaataaccagGaaagccacaaagagctgccc	8	12	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr11:7950117G>A	ENST00000309838.2	-	1	92	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAATAACCAGGAAAGCCACAA	0.448													86	26					0	0	1	0	0	A	7950117	G	A	7950117	2	1	31	1	0	0	0	0	0	0	0	1	10941	1165	41	3		3	OR10A6	11	7950117	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		7950117	127056399	45	2991										
OR5D14	219436	broad.mit.edu	37	chr11	55563417	55563417	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tgaccgctttgtggccatctGcaatcctctgctttatacag	8	12	2	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr11:55563417G>A	ENST00000335605.1	+	1	386	c.386G>A	c.(385-387)tGc>tAc	p.C129Y		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				GTGGCCATCTGCAATCCTCTG	0.532													7	50					0	0	1	0	0	A	55563417	G	A	55563417	3	1	31	1	0	0	0	0	1	0	0	0	11201	1319	46	3	388	3	OR5D14	11	55563417	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	47613300	55563417	79443099	46	2992										
SLC43A1	8501	broad.mit.edu	37	chr11	57281459	57281459	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gtgctggaatagaagccctcGttcttcagaatgatcaacag	10	9	3	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr11:57281459G>C	ENST00000278426.3	-	2	481	c.126C>G	c.(124-126)aaC>aaG	p.N42K	SLC43A1_ENST00000528450.1_Missense_Mutation_p.N42K	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	42					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						AGAAGCCCTCGTTCTTCAGAA	0.597													19	3					0	0	1	0	0	C	57281459	G	C	57281459	3	2	31	1	0	0	0	0	1	0	0	0	14686	1136	40	5	1609	5	SLC43A1	11	57281459	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	1718042	57281459	77725057	47	2993										
B4GALNT3	283358	broad.mit.edu	37	chr12	667810	667810	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gaggctgcattgtggggccaCcccccagtggcctgagggtg	17	12	0	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:667810C>G	ENST00000266383.5	+	18	2757	c.2744C>G	c.(2743-2745)aCc>aGc	p.T915S		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	915						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGTGGGGCCACCCCCCAGTGG	0.567													9	30					0	0	1	0	0	G	667810	C	G	667810	3	3	31	1	0	0	0	0	1	0	0	0	1266	507	18	5	2814	5	B4GALNT3	12	667810	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		667810	133184085	48	2994										
ZNF384	0	broad.mit.edu	37	chr12	6787485	6787485	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gggtcgatgctaccttcttgGagaggtcagggacaacctgc	14	10	2	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:6787485G>C	ENST00000396795.1	-	5	991	c.494C>G	c.(493-495)tCc>tGc	p.S165C	ZNF384_ENST00000319770.3_Missense_Mutation_p.S149C|ZNF384_ENST00000396799.2_Missense_Mutation_p.S165C|ZNF384_ENST00000396801.3_Missense_Mutation_p.S165C|ZNF384_ENST00000361959.3_Missense_Mutation_p.S165C|ZNF384_ENST00000355772.4_Missense_Mutation_p.S110C			Q8TF68	ZN384_HUMAN	zinc finger protein 384	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						TACCTTCTTGGAGAGGTCAGG	0.607			T	"EWSR1, TAF15 "	ALL								24	20					0	0	1	0	0	C	6787485	G	C	6787485	3	2	31	1	0	0	0	0	1	0	0	0	17931	1174	41	2	1263	2	ZNF384	12	6787485	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	6119675	6787485	127064410	49	2995										
SCN8A	6334	broad.mit.edu	37	chr12	52139791	52139791	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gacagaatcaacagtataatGagtgttgttacaaatacact	7	6	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:52139791G>A	ENST00000354534.5	+	13	2281	c.2103G>A	c.(2101-2103)atG>atA	p.M701I	SCN8A_ENST00000545061.1_Missense_Mutation_p.M701I|SCN8A_ENST00000550891.1_Missense_Mutation_p.M701I	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	701					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ACAGTATAATGAGTGTTGTTA	0.403													22	19					0	0	1	0	0	A	52139791	G	A	52139791	3	1	31	1	0	0	0	0	1	0	0	0	13977	1290	45	3	2149	3	SCN8A	12	52139791	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	45352306	52139791	81712104	50	2996										
NCKAP1L	3071	broad.mit.edu	37	chr12	54914489	54914489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tctctgcagctttcatcttcGtatctttgagaagatgtttg	8	8	4	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:54914489G>A	ENST00000293373.6	+	17	1716	c.1637G>A	c.(1636-1638)cGt>cAt	p.R546H	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R496H	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	546					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTTCATCTTCGTATCTTTGAG	0.393													35	75					0	0	1	0	0	A	54914489	G	A	54914489	3	1	31	1	0	0	0	0	1	0	0	0	10268	1145	40	1	1703	1	NCKAP1L	12	54914489	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	2774698	54914489	78937406	51	2997										
PPFIA2	8499	broad.mit.edu	37	chr12	81657012	81657012	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	aatgcaaaactactgtaccaTctgttgtcatttttcttgac	5	9	3	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:81657012T>A	ENST00000550584.2	-	30	4008	c.3713A>T	c.(3712-3714)gAt>gTt	p.D1238V	PPFIA2_ENST00000548586.1_Missense_Mutation_p.D1232V|PPFIA2_ENST00000541570.2_Missense_Mutation_p.D774V|PPFIA2_ENST00000549396.1_Missense_Mutation_p.D1238V|PPFIA2_ENST00000550359.2_Missense_Mutation_p.D1085V|PPFIA2_ENST00000443686.3_Missense_Mutation_p.D1133V|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000541017.1_Missense_Mutation_p.D424V|PPFIA2_ENST00000407050.4_Missense_Mutation_p.D1137V|PPFIA2_ENST00000552948.1_Missense_Mutation_p.D1217V|PPFIA2_ENST00000333447.7_Missense_Mutation_p.D1226V|PPFIA2_ENST00000549325.1_Missense_Mutation_p.D1223V	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	1137										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TACTGTACCATCTGTTGTCAT	0.398													3	5					0	0	1	0	0	A	81657012	T	A	81657012	3	1	31	1	0	0	0	0	1	0	0	0	12354	1435	50	4	68	4	PPFIA2	12	81657012	Missense_Mutation	SNP	T	TCGA-N8-A4PQ-01A-11D-A28R-08	26742523	81657012	52194883	52	2998										
STAB2	55576	broad.mit.edu	37	chr12	104155079	104155079	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cctcttctcatttccctagaCggagaccaggtttgttgatg	9	11	2	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:104155079C>T	ENST00000388887.2	+	66	7454	c.7248_splice	c.e66-1	p.T2417_splice	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2417	FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.T2417M(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TTTCCCTAGACGGAGACCAGG	0.512													7	33					0	0	1	0	0	T	104155079	C	T	104155079	5	4	31	1	0	0	0	0	0	0	1	0	15293	550	19	1	7512	1	STAB2	12	104155079	Splice_Site	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	22498067	104155079	29696816	53	2999										
MPHOSPH9	10198	broad.mit.edu	37	chr12	123703047	123703047	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cccatgatgttatagcattaCtatttaagaagagaaaacca	6	7	0	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr12:123703047C>A	ENST00000606320.1	-	6	1079		c.e6-1		MPHOSPH9_ENST00000541076.2_Splice_Site|MPHOSPH9_ENST00000302349.5_Splice_Site|MPHOSPH9_ENST00000392425.3_Splice_Site			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9						M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TATAGCATTACTATTTAAGAA	0.398													9	75					0.000673444	0.000698857	1	1	0	A	123703047	C	A	123703047	5	1	31	1	0	0	0	0	0	0	1	0	9776	579	20	5	2755	5	MPHOSPH9	12	123703047	Splice_Site	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	19547968	123703047	10148848	54	3000										
LHFP	10186	broad.mit.edu	37	chr13	40175117	40175117	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gtgcagatcctccattctgcGctggggatgccctggaagga	14	11	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr13:40175117G>A	ENST00000379589.3	-	2	699	c.237C>T	c.(235-237)agC>agT	p.S79S		NM_005780.2	NP_005771.1	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner	79						integral to membrane	DNA binding		HMGA2/LHFP(2)	breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(6)|prostate(2)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		TCCATTCTGCGCTGGGGATGC	0.597			T	HMGA2	lipoma								144	47					0	0	1	0	0	A	40175117	G	A	40175117	2	1	31	1	0	0	0	0	0	0	0	1	8802	1078	38	1		1	LHFP	13	40175117	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		40175117	74994761	55	3001										
WDR72	256764	broad.mit.edu	37	chr15	53889416	53889416	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tgacgggtatctttcccaaaCtcttcatgtgttgttgaact	8	9	3	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:53889416C>A	ENST00000396328.1	-	18	3247	c.3008G>T	c.(3007-3009)aGt>aTt	p.S1003I	WDR72_ENST00000557913.1_Missense_Mutation_p.S1000I|WDR72_ENST00000360509.5_Missense_Mutation_p.S1003I|WDR72_ENST00000559418.1_Missense_Mutation_p.S1013I	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1003										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CTTTCCCAAACTCTTCATGTG	0.388													15	67					5.01169e-05	5.45828e-05	1	1	0	A	53889416	C	A	53889416	3	1	31	1	0	0	0	0	1	0	0	0	17381	565	20	5	312	5	WDR72	15	53889416	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		53889416	48641976	56	3002										
RHCG	51458	broad.mit.edu	37	chr15	90023572	90023572	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ggttgcgtcggtagaggatcCgggtcactgtgagcccaaag	16	9	1	2	rs149510924	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr15:90023572C>T	ENST00000268122.4	-	4	658	c.590G>A	c.(589-591)cGg>cAg	p.R197Q	RHCG_ENST00000544600.1_Missense_Mutation_p.R197Q	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	197					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding	p.R197L(1)|p.R197Q(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					GTAGAGGATCCGGGTCACTGT	0.557													56	26					0	0	1	0	0	T	90023572	C	T	90023572	3	4	31	1	0	0	0	0	1	0	0	0	13375	652	23	1	877	1	RHCG	15	90023572	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	36134156	90023572	12507820	57	3003										
HBA1	3039	broad.mit.edu	37	chr16	227404	227404	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	accgtgctgacctccaaataCcgttaagctggagcctcggt	10	13	0	1	rs121913128		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr16:227404C>A	ENST00000320868.5	+	3	460	c.423C>A	c.(421-423)taC>taA	p.Y141*	HBA1_ENST00000397797.1_Nonsense_Mutation_p.Y109*	NM_000558.3	NP_000549.1	P69905	HBA_HUMAN	hemoglobin, alpha 1	141			Y -> H (in Rouen/Ethiopia; O(2) affinity up).		hydrogen peroxide catabolic process|positive regulation of cell death|protein heterooligomerization	cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding			lung(1)	1		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)			Amodiaquine(DB00613)|Chloroquine(DB00608)|Iron Dextran(DB00893)|Mefloquine(DB00358)|Primaquine(DB01087)|Quinine(DB00468)	CCTCCAAATACCGTTAAGCTG	0.647											OREG0003687	type=REGULATORY REGION|Gene=SERPINB9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	17					0.000602214	0.000630891	1	1	0	A	227404	C	A	227404	4	1	31	1	0	0	0	0	0	1	0	0	7016	518	18	5	433	5	HBA1	16	227404	Nonsense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		227404	90127349	58	3004										
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:7577120C>T	ENST00000420246.2	-	8	950	c.818G>A	c.(817-819)cGt>cAt	p.R273H	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R273H|TP53_ENST00000445888.2_Missense_Mutation_p.R273H|TP53_ENST00000269305.4_Missense_Mutation_p.R273H|TP53_ENST00000359597.4_Missense_Mutation_p.R273H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	8					0	0	1	0	0	T	7577120	C	T	7577120	3	4	31	1	0	0	0	0	1	0	0	0	16441	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		7577120	73618090	59	3005										
KDM6B	23135	broad.mit.edu	37	chr17	7751444	7751444	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gcctccagcccctccttcctCctgccaccaaaatacctcag	4	21	1	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:7751444C>T	ENST00000254846.5	+	11	2227	c.1838C>T	c.(1837-1839)tCc>tTc	p.S613F	KDM6B_ENST00000448097.2_Missense_Mutation_p.S613F	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	613	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CCTCCTTCCTCCTGCCACCAA	0.677													5	89					0	0	1	0	0	T	7751444	C	T	7751444	3	4	31	1	0	0	0	0	1	0	0	0	8180	855	30	3	1868	3	KDM6B	17	7751444	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	174324	7751444	73443766	60	3006										
KCNJ12	3768	broad.mit.edu	37	chr17	21319329	21319329	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cgcaagagccacattgtggaGgcccatgtgcgcgcgcagct	14	13	0	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:21319329G>A	ENST00000583088.1	+	3	1570	c.675G>A	c.(673-675)gaG>gaA	p.E225E	KCNJ12_ENST00000331718.5_Silent_p.E225E	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		ACATTGTGGAGGCCCATGTGC	0.642										Prostate(3;0.18)			4	84					0	0	1	0	0	A	21319329	G	A	21319329	2	1	31	1	0	0	0	0	0	0	0	1	8089	991	35	3		3	KCNJ12	17	21319329	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	13567885	21319329	59875881	61	3007										
CCR7	1236	broad.mit.edu	37	chr17	38711153	38711153	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	aacttgacgccgatgaaggcGtacaagaaagggttgacgca	13	8	0	4			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:38711153G>A	ENST00000246657.2	-	3	1040	c.978C>T	c.(976-978)taC>taT	p.Y326Y	CCR7_ENST00000579344.1_Silent_p.Y320Y	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	326					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				CGATGAAGGCGTACAAGAAAG	0.587													14	45					0	0	1	0	0	A	38711153	G	A	38711153	2	1	31	1	0	0	0	0	0	0	0	1	2968	1140	40	1		1	CCR7	17	38711153	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	17391824	38711153	42484057	62	3008										
PYY	5697	broad.mit.edu	37	chr17	42030806	42030806	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	taggcagacgagcagggccaGaagcactgtggtcaaggcgg	17	9	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:42030806G>C	ENST00000360085.2	-	5	586	c.46C>G	c.(46-48)Ctg>Gtg	p.L16V	PYY_ENST00000592796.1_Missense_Mutation_p.L16V	NM_004160.4	NP_004151.3	P10082	PYY_HUMAN	peptide YY	16					cell proliferation|cell-cell signaling|cellular component movement|cytoskeleton organization|digestion|G-protein coupled receptor protein signaling pathway	soluble fraction				endometrium(1)|ovary(1)	2		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.12)		AGCAGGGCCAGAAGCACTGTG	0.662													4	22					0	0	1	0	0	C	42030806	G	C	42030806	3	2	31	1	0	0	0	0	1	0	0	0	12919	933	33	2	259	2	PYY	17	42030806	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	3319653	42030806	39164404	63	3009										
TTLL6	284076	broad.mit.edu	37	chr17	46847315	46847315	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	taagtgtggaggggtctgctGcttcttgcatttaaaggata	13	5	2	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:46847315G>A	ENST00000393382.3	-	14	2326	c.2185C>T	c.(2185-2187)Cag>Tag	p.Q729*	TTLL6_ENST00000433608.2_Nonsense_Mutation_p.Q422*	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	681						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GGGGTCTGCTGCTTCTTGCAT	0.502													11	105					0	0	1	0	0	A	46847315	G	A	46847315	4	1	31	1	0	0	0	0	0	1	0	0	16792	1328	46	3	498	3	TTLL6	17	46847315	Nonsense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	4816509	46847315	34347895	64	3010										
TTLL6	284076	broad.mit.edu	37	chr17	46847428	46847428	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	agattgagagttgggtggtgGattctggggtggtttctacg	18	3	2	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:46847428G>A	ENST00000393382.3	-	14	2213	c.2072C>T	c.(2071-2073)tCc>tTc	p.S691F	TTLL6_ENST00000433608.2_Missense_Mutation_p.S384F	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	643						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TTGGGTGGTGGATTCTGGGGT	0.498													11	88					0	0	1	0	0	A	46847428	G	A	46847428	3	1	31	1	0	0	0	0	1	0	0	0	16792	1174	41	3	611	3	TTLL6	17	46847428	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	113	46847428	34347782	65	3011										
KIF2B	84643	broad.mit.edu	37	chr17	51901710	51901710	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cctgaagtcaggacggataaTgcatggcaagttttccctcg	11	10	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:51901710T>G	ENST00000268919.4	+	1	1472	c.1316T>G	c.(1315-1317)aTg>aGg	p.M439R		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	439	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGACGGATAATGCATGGCAAG	0.507													10	42					0	0	1	0	0	G	51901710	T	G	51901710	3	3	31	1	0	0	0	0	1	0	0	0	8339	1464	51	4	1318	4	KIF2B	17	51901710	Missense_Mutation	SNP	T	TCGA-N8-A4PQ-01A-11D-A28R-08	5054282	51901710	29293500	66	3012										
TEX2	55852	broad.mit.edu	37	chr17	62272447	62272447	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tcatagttgtaaatctcattCatccatccctgatgaagaaa	5	9	3	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:62272447C>A	ENST00000258991.3	-	3	1737	c.1653G>T	c.(1651-1653)atG>atT	p.M551I	TEX2_ENST00000583097.1_Missense_Mutation_p.M551I|TEX2_ENST00000584379.1_Missense_Mutation_p.M551I			Q8IWB9	TEX2_HUMAN	testis expressed 2	551					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AAATCTCATTCATCCATCCCT	0.383													6	56					5.9392e-07	6.66645e-07	1	1	0	A	62272447	C	A	62272447	3	1	31	1	0	0	0	0	1	0	0	0	15839	826	29	2	1791	2	TEX2	17	62272447	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	10370737	62272447	18922763	67	3013										
SGSH	6448	broad.mit.edu	37	chr17	78184304	78184304	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	agagagcttctcctccaggaCgccgtcgggggcgcacaccc	13	16	1	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr17:78184304C>T	ENST00000326317.6	-	8	1542	c.1456G>A	c.(1456-1458)Gtc>Atc	p.V486I	SGSH_ENST00000534910.1_Missense_Mutation_p.V283I	NM_000199.3	NP_000190.1	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase	486			V -> F (in MPS3A).		proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TCCTCCAGGACGCCGTCGGGG	0.652													5	15					0	0	1	0	0	T	78184304	C	T	78184304	3	4	31	1	0	0	0	0	1	0	0	0	14274	536	19	1	56	1	SGSH	17	78184304	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	15911857	78184304	3010906	68	3014										
ZNF792	126375	broad.mit.edu	37	chr19	35448925	35448925	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	cttgtagttgacagcgccctGataaggtctgttctcagagc	11	10	2	3			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:35448925G>C	ENST00000404801.1	-	4	2220	c.1834C>G	c.(1834-1836)Cag>Gag	p.Q612E	ZNF792_ENST00000605484.1_Missense_Mutation_p.Q545E	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACAGCGCCCTGATAAGGTCTG	0.488													10	17					0	0	1	0	0	C	35448925	G	C	35448925	3	2	31	1	0	0	0	0	1	0	0	0	18212	1299	45	2	68	2	ZNF792	19	35448925	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08		35448925	23680058	69	3015										
MAG	4099	broad.mit.edu	37	chr19	35791110	35791110	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	catcgagggctcccacgtgaGcctgctctgtggggctgaca	14	13	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:35791110G>T	ENST00000361922.4	+	6	923	c.773G>T	c.(772-774)aGc>aTc	p.S258I	MAG_ENST00000392213.3_Missense_Mutation_p.S258I|MAG_ENST00000537831.2_Missense_Mutation_p.S233I	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	258	Ig-like C2-type 2.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCCCACGTGAGCCTGCTCTGT	0.677													7	9					0.00198382	0.00202056	1	1	0	T	35791110	G	T	35791110	3	4	31	1	0	0	0	0	1	0	0	0	9207	971	34	5	787	5	MAG	19	35791110	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	342185	35791110	23337873	70	3016										
SAMD4B	55095	broad.mit.edu	37	chr19	39868449	39868449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	acatccccagccagtttacaCgggtgatgggcaaaggtgag	13	10	0	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:39868449C>T	ENST00000314471.6	+	10	2464	c.1429C>T	c.(1429-1431)Cgg>Tgg	p.R477W	SAMD4B_ENST00000598913.1_Missense_Mutation_p.R477W|SAMD4B_ENST00000596368.1_Intron	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	477							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCAGTTTACACGGGTGATGGG	0.592													21	51					0	0	1	0	0	T	39868449	C	T	39868449	3	4	31	1	0	0	0	0	1	0	0	0	13873	527	19	1	1451	1	SAMD4B	19	39868449	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	4077339	39868449	19260534	71	3017										
FCGBP	8857	broad.mit.edu	37	chr19	40374023	40374023	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gctgtgttcctggcacaccaCgactttacccacatggcacg	9	15	0	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:40374023C>T	ENST00000221347.6	-	26	12062	c.12055G>A	c.(12055-12057)Gtg>Atg	p.V4019M		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4019	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCACACCACGACTTTACCC	0.642													3	18					0	0	1	0	0	T	40374023	C	T	40374023	3	4	31	1	0	0	0	0	1	0	0	0	5810	536	19	1	4206	1	FCGBP	19	40374023	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	505574	40374023	18754960	72	3018										
LRRC4B	94030	broad.mit.edu	37	chr19	51022478	51022478	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tcgatggggttgttccgcagCcagagctcccgcagcttgga	14	12	0	1			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr19:51022478C>T	ENST00000599957.1	-	3	689	c.492G>A	c.(490-492)tgG>tgA	p.W164*	LRRC4B_ENST00000389201.3_Nonsense_Mutation_p.W164*			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	164						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		TGTTCCGCAGCCAGAGCTCCC	0.652													40	53					0	0	1	0	0	T	51022478	C	T	51022478	4	4	31	1	0	0	0	0	0	1	0	0	9051	740	26	3	1653	3	LRRC4B	19	51022478	Nonsense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	10648455	51022478	8106505	73	3019										
PROKR2	128674	broad.mit.edu	37	chr20	5282948	5282948	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	acacagtggggaagaagtcaCgaacgatggtgaaaccgtag	14	7	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:5282948C>T	ENST00000546004.1	-	3	1139	c.893G>A	c.(892-894)cGt>cAt	p.R298H	PROKR2_ENST00000217270.3_Missense_Mutation_p.R298H			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	298						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAAGAAGTCACGAACGATGGT	0.562										HNSCC(71;0.22)			42	22					0	0	1	0	0	T	5282948	C	T	5282948	3	4	31	1	0	0	0	0	1	0	0	0	12604	536	19	1	264	1	PROKR2	20	5282948	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		5282948	57742572	74	3020										
SSTR4	6754	broad.mit.edu	37	chr20	23016994	23016994	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tgaccagccttgatgccaccGtcaaccacgtgtcccttatc	7	16	1	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:23016994G>A	ENST00000255008.3	+	1	938	c.874G>A	c.(874-876)Gtc>Atc	p.V292I	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	292					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGATGCCACCGTCAACCACGT	0.567													46	21					0	0	1	0	0	A	23016994	G	A	23016994	3	1	31	1	0	0	0	0	1	0	0	0	15255	1145	40	1	876	1	SSTR4	20	23016994	Missense_Mutation	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	17734046	23016994	40008526	75	3021										
NFATC2	4773	broad.mit.edu	37	chr20	50139907	50139907	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	gccacaggggggtacccagcCggggagccgtggtcctgggg	20	12	0	0			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:50139907C>T	ENST00000371564.3	-	2	1092	c.873G>A	c.(871-873)ccG>ccA	p.P291P	NFATC2_ENST00000414705.1_Silent_p.P271P|NFATC2_ENST00000396009.3_Silent_p.P291P	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	291					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGTACCCAGCCGGGGAGCCGT	0.697													16	17					0	0	1	0	0	T	50139907	C	T	50139907	2	4	31	1	0	0	0	0	0	0	0	1	10408	639	23	1		1	NFATC2	20	50139907	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	27122913	50139907	12885613	76	3022										
SS18L1	26039	broad.mit.edu	37	chr20	60736500	60736500	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	tgttgcctgcagccgcccacGcagaacatgaacctgggccc	11	16	0	2			TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr20:60736500G>A	ENST00000331758.3	+	4	266	c.240G>A	c.(238-240)acG>acA	p.T80T	SS18L1_ENST00000421564.1_Silent_p.T80T|SS18L1_ENST00000370848.4_Silent_p.T83T	NM_198935.1	NP_945173.1	O75177	CREST_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 1	80	N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1 (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore			SS18L1/SSX1(2)	ovary(2)|skin(1)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			AGCCGCCCACGCAGAACATGA	0.622			T	SSX1	synovial sarcoma								27	52					0	0	1	0	0	A	60736500	G	A	60736500	2	1	31	1	0	0	0	0	0	0	0	1	15231	1074	38	1		1	SS18L1	20	60736500	Silent	SNP	G	TCGA-N8-A4PQ-01A-11D-A28R-08	10596593	60736500	2289020	77	3023										
BAGE2	85319	broad.mit.edu	37	chr21	11062343	11062344	+	RNA	INS	-	-	AG													0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	taaattctctagtaaaagacINSagcaactttcaaaatatgca					rs148978863		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11062343_11062344insAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGTAAAAGACAGCAACTTTCA	0.267													4	6	---	---	---	---						AG	11062344	-	AG	11062343	6	5	31	0	1	1	1	0	0	0	0	0	1290	493	17	0		0	BAGE2	21	11062343	RNA	INS	-	TCGA-N8-A4PQ-01A-11D-A28R-08		11062343	37067552	78	3024										
BAGE2	85319	broad.mit.edu	37	chr21	11066883	11066884	+	RNA	INS	-	-	AA													0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	actttggggttagaatccatINSaatactctcagtgtcaacca					rs147216020		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chr21:11066883_11066884insAA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTAGAATCCATAATACTCTCAG	0.366													3	3	---	---	---	---						AA	11066884	-	AA	11066883	6	5	31	0	1	1	1	0	0	0	0	0	1290	1421	49	0		0	BAGE2	21	11066883	RNA	INS	-	TCGA-N8-A4PQ-01A-11D-A28R-08	4540	11066883	37063012	79	3025										
SHOX	6473	broad.mit.edu	37	chrX	601571	601571	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ccaaggtttggttccagaacCggagagccaagtgccgcaaa	12	11	0	2	rs137852557		TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chrX:601571C>A	ENST00000381578.1	+	4	1193	c.502C>A	c.(502-504)Cgg>Agg	p.R168R	SHOX_ENST00000334060.3_Silent_p.R168R|SHOX_ENST00000554971.1_Silent_p.R168R|SHOX_ENST00000381575.1_Silent_p.R168R	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	168			R -> W (in LMD).		skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTTCCAGAACCGGAGAGCCAA	0.592													5	74					0.0215528	0.0217505	1	1	0	A	601571	C	A	601571	2	1	31	1	0	0	0	0	0	0	0	1	14342	643	23	5		5	SHOX	23	601571	Silent	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08		601571	154668989	80	3026										
FOXR2	139628	broad.mit.edu	37	chrX	55650343	55650343	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.075	6	1	0.881547139403707	2.88198103266596	0.19718817591925	0.148606811145511	0.651583710407241	0	ctcagaagaggagacccagtCctgatggagatggtcctccc	12	12	1	5	rs142979047	byFrequency	TCGA-N8-A4PQ-01A-11D-A28R-08	TCGA-N8-A4PQ-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3eaab79-ec94-43ea-bdeb-8e2b2a0ef27f	cab88f55-36e4-4645-a74e-6e3a2911e9c8	g.chrX:55650343C>A	ENST00000339140.3	+	1	511	c.199C>A	c.(199-201)Cct>Act	p.P67T		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	67					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						GAGACCCAGTCCTGATGGAGA	0.552													25	36					1.1804e-14	1.36677e-14	1	1	0	A	55650343	C	A	55650343	3	1	31	1	0	0	0	0	1	0	0	0	6065	855	30	2	201	2	FOXR2	23	55650343	Missense_Mutation	SNP	C	TCGA-N8-A4PQ-01A-11D-A28R-08	55048772	55650343	99620217	81	3027										
PEX14	5195	broad.mit.edu	37	chr1	10659423	10659423	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	acctcatatctcagccatacAgtaagtcacccgctcaaact	4	15	4	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr1:10659423A>G	ENST00000356607.4	+	4	378	c.298_splice	c.e4+1	p.S100_splice	PEX14_ENST00000538836.1_Splice_Site_p.S36_splice	NM_004565.2	NP_004556.1	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	100					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGCCATACAGTAAGTCACC	0.557													16	74					0	0	1	0	0	G	10659423	A	G	10659423	5	3	32	1	0	0	0	0	0	0	1	0	11789	202	7	4	312	4	PEX14	1	10659423	Splice_Site	SNP	A	TCGA-N8-A56S-01A-11D-A28R-08		10659423	238591198	1	3028										
PRAMEF10	343071	broad.mit.edu	37	chr1	12952782	12952782	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gaagtccactttctcagatgGccatgagccacagttagggc	11	11	1	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr1:12952782G>A	ENST00000235347.4	-	4	1469	c.1390C>T	c.(1390-1392)Cca>Tca	p.P464S		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	464										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTCAGATGGCCATGAGCCA	0.517													30	7					0	0	1	0	0	A	12952782	G	A	12952782	3	1	32	1	0	0	0	0	1	0	0	0	12474	1203	42	3	38	3	PRAMEF10	1	12952782	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	2293359	12952782	236297839	2	3029										
DAB1	1600	broad.mit.edu	37	chr1	57535038	57535038	+	Frame_Shift_Del	DEL	A	A	-													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	caagcaattttatacctgatAaatgttttcttccgtttcgg							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr1:57535038delA	ENST00000371236.2	-	8	921	c.658delT	c.(658-660)atfs	p.Y220fs	DAB1_ENST00000371234.4_Frame_Shift_Del_p.Y220fs|DAB1_ENST00000414851.2_Intron|DAB1_ENST00000420954.2_Intron|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000371231.1_Frame_Shift_Del_p.Y220fs|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	220					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TATACCTGATAAATGTTTTCT	0.423													47	43	---	---	---	---						-	57535038	A	-	57535038	7	5	32	1	0	1	0	1	0	0	0	0	4241	362	13	0	1037	0	DAB1	1	57535038	Frame_Shift_Del	DEL	A	TCGA-N8-A56S-01A-11D-A28R-08	44582256	57535038	191715583	3	3030										
SEC22B	9554	broad.mit.edu	37	chr1	145109293	145109294	+	RNA	INS	-	-	A													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	actccgtctcaaaaaaaaagINSaaaaaaaaaaaccaaaaaca					rs7364468		TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr1:145109293_145109294insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										caaaaaaaaagaaaaaaaaaaa	0.431													4	2	---	---	---	---						A	145109294	-	A	145109293	6	5	32	0	1	1	1	0	0	0	0	0	14042	957	33	0		0	SEC22B	1	145109293	RNA	INS	-	TCGA-N8-A56S-01A-11D-A28R-08	87574255	145109293	104141328	4	3031										
CAD	790	broad.mit.edu	37	chr2	27449457	27449457	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	cctggccagtaaggccacagGttatccactggcttatgtgg	12	11	0	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr2:27449457G>T	ENST00000264705.4	+	14	2258	c.2096G>T	c.(2095-2097)gGt>gTt	p.G699V	CAD_ENST00000403525.1_Missense_Mutation_p.G636V	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	699	ATP-grasp 1.|CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AAGGCCACAGGTTATCCACTG	0.522													34	43					1.45844e-13	1.6782e-13	1	1	0	T	27449457	G	T	27449457	3	4	32	1	0	0	0	0	1	0	0	0	2583	1261	44	5	2150	5	CAD	2	27449457	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08		27449457	215749916	5	3032										
MPV17	4358	broad.mit.edu	37	chr2	27535950	27535950	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ctccaccagctgctgtgagaTaatgtcacccaggcccatca	8	15	2	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr2:27535950T>C	ENST00000380044.1	-	3	152	c.97A>G	c.(97-99)Atc>Gtc	p.I33V	MPV17_ENST00000405076.1_Missense_Mutation_p.I33V|MPV17_ENST00000233545.2_Missense_Mutation_p.I33V|MPV17_ENST00000357186.6_Intron|MPV17_ENST00000402310.1_Missense_Mutation_p.I33V|MPV17_ENST00000405983.1_Missense_Mutation_p.I48V|MPV17_ENST00000402722.1_Intron|MPV17_ENST00000403262.2_Missense_Mutation_p.I33V	NM_002437.4	NP_002428.1	P39210	MPV17_HUMAN	MpV17 mitochondrial inner membrane protein	33					cellular response to reactive oxygen species|glomerular basement membrane development|homeostatic process|inner ear development|mitochondrial genome maintenance|regulation of reactive oxygen species metabolic process	integral to peroxisomal membrane|mitochondrial inner membrane				lung(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTGTGAGATAATGTCACCC	0.592													37	55					0	0	1	0	0	C	27535950	T	C	27535950	3	2	32	1	0	0	0	0	1	0	0	0	9793	1406	49	4	457	4	MPV17	2	27535950	Missense_Mutation	SNP	T	TCGA-N8-A56S-01A-11D-A28R-08	86493	27535950	215663423	6	3033										
GCC2	9648	broad.mit.edu	37	chr2	109087815	109087815	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ggttcaaatgaaagttctctCtgaagacaaagaagtattgt	9	5	3	4			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr2:109087815C>G	ENST00000309863.6	+	6	2744	c.2030C>G	c.(2029-2031)tCt>tGt	p.S677C		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	677					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AAAGTTCTCTCTGAAGACAAA	0.333													57	99					0	0	1	0	0	G	109087815	C	G	109087815	3	3	32	1	0	0	0	0	1	0	0	0	6325	913	32	2	2052	2	GCC2	2	109087815	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	81551865	109087815	134111558	7	3034										
TTN	7273	broad.mit.edu	37	chr2	179411904	179411904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	cacccaaagaattgtattacGttctttcttctcaacccagt	4	12	3	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr2:179411904G>A	ENST00000589042.1	-	340	94572	c.94348C>T	c.(94348-94350)Cgt>Tgt	p.R31450C	TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R28882C|TTN_ENST00000342175.6_Missense_Mutation_p.R22577C|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R29809C|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R22510C|TTN_ENST00000460472.2_Missense_Mutation_p.R22385C|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29809	Fibronectin type-III 129.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R22510C(1)|p.R28880C(1)|p.R28882C(1)|p.R22577C(1)|p.R22385C(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGTATTACGTTCTTTCTTC	0.423													95	135					0	0	1	0	0	A	179411904	G	A	179411904	3	1	32	1	0	0	0	0	1	0	0	0	16796	1145	40	1	13723	1	TTN	2	179411904	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	70324089	179411904	63787469	8	3035										
NBEAL2	23218	broad.mit.edu	37	chr3	47050735	47050735	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	agcagccagttcgcgcggaaGctgtggcggtcctcgcggcg	17	13	0	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr3:47050735G>A	ENST00000450053.3	+	54	8369	c.8190G>A	c.(8188-8190)aaG>aaA	p.K2730K	NBEAL2_ENST00000383740.2_Silent_p.K979K|NBEAL2_ENST00000292309.5_Silent_p.K2546K	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2730							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCGCGCGGAAGCTGTGGCGGT	0.697													6	5					0	0	1	0	0	A	47050735	G	A	47050735	2	1	32	1	0	0	0	0	0	0	0	1	10236	962	34	3		3	NBEAL2	3	47050735	Silent	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08		47050735	150971695	9	3036										
LPP	4026	broad.mit.edu	37	chr3	188327559	188327559	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gaaccctcctgggatgtatcCagtcactggtcccaagaaga	10	12	1	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr3:188327559C>G	ENST00000312675.4	+	6	1286	c.1040C>G	c.(1039-1041)cCa>cGa	p.P347R	LPP_ENST00000543006.1_Missense_Mutation_p.P347R|LPP_ENST00000471917.1_3'UTR|LPP_ENST00000448637.1_Missense_Mutation_p.P347R	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	347	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GGGATGTATCCAGTCACTGGT	0.522			T	"HMGA2, MLL, C12orf9"	"lipoma, leukemia"								33	56					0	0	1	0	0	G	188327559	C	G	188327559	3	3	32	1	0	0	0	0	1	0	0	0	8967	594	21	5	1054	5	LPP	3	188327559	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	141276824	188327559	9694871	10	3037										
RFC1	5981	broad.mit.edu	37	chr4	39304717	39304718	+	Frame_Shift_Del	DEL	TC	TC	-													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	cctcattgcctgccatgccaTctacttcatccatgatgaga							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr4:39304717_39304718delTC	ENST00000381897.1	-	16	2300_2301	c.2167_2168delGA	c.(2167-2169)tfs	p.D723fs	RFC1_ENST00000349703.2_Frame_Shift_Del_p.D722fs	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	723					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						TGCCATGCCATCTACTTCATCC	0.416													16	30	---	---	---	---						-	39304718	TC	-	39304717	7	5	32	1	0	1	0	1	0	0	0	0	13295	1435	50	0	1318	0	RFC1	4	39304717	Frame_Shift_Del	DEL	TC	TCGA-N8-A56S-01A-11D-A28R-08		39304717	151849559	11	3038										
AGXT2	64902	broad.mit.edu	37	chr5	35035360	35035360	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tgtctatgttgtttgagtgcGccctggccatcagcatggcc	12	11	2	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr5:35035360G>A	ENST00000231420.6	-	5	748	c.548C>T	c.(547-549)gCg>gTg	p.A183V		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	183					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GTTTGAGTGCGCCCTGGCCAT	0.433													19	80					0	0	1	0	0	A	35035360	G	A	35035360	3	1	32	1	0	0	0	0	1	0	0	0	402	1087	38	1	1036	1	AGXT2	5	35035360	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08		35035360	145879900	12	3039										
NNT	23530	broad.mit.edu	37	chr5	43675666	43675666	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ggaggctatggcaccacttcAacagctggtggaaaacccat	11	11	1	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr5:43675666A>C	ENST00000264663.5	+	18	2909	c.2688A>C	c.(2686-2688)tcA>tcC	p.S896S	NNT_ENST00000344920.4_Silent_p.S896S|NNT_ENST00000512996.2_Silent_p.S765S	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	896					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	GCACCACTTCAACAGCTGGTG	0.403													21	44					0	0	1	0	0	C	43675666	A	C	43675666	2	2	32	1	0	0	0	0	0	0	0	1	10556	117	5	4		4	NNT	5	43675666	Silent	SNP	A	TCGA-N8-A56S-01A-11D-A28R-08	8640306	43675666	137239594	13	3040										
MAP3K1	4214	broad.mit.edu	37	chr5	56178633	56178643	+	Frame_Shift_Del	DEL	CCCCATAGTTC	CCCCATAGTTC	-													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tcagcgtctcaggatgccctCcccatagttcctcagctgca							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr5:56178633_56178643delCCCCATAGTTC	ENST00000399503.3	+	14	3606_3616	c.3606_3616delCCCCATAGTTC	c.(3604-3618)ctctfs	p.LPIVP1202fs		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1202					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AGGATGCCCTCCCCATAGTTCCTCAGCTGCA	0.417													18	32	---	---	---	---						-	56178643	CCCCATAGTTC	-	56178633	7	5	32	1	0	1	0	1	0	0	0	0	9292	842	30	0	3660	0	MAP3K1	5	56178633	Frame_Shift_Del	DEL	CCCCATAGTTC	TCGA-N8-A56S-01A-11D-A28R-08	12502967	56178633	124736627	14	3041										
PCDHA4	0	broad.mit.edu	37	chr5	140188315	140188315	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tttcggtgcatgcggagagcGgcaaggtgtacgcgctgcag	17	9	0	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr5:140188315G>A	ENST00000530339.1	+	1	1543	c.1543G>A	c.(1543-1545)Ggc>Agc	p.G515S	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.G515S|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.G515S|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGGAGAGCGGCAAGGTGTA	0.677													128	96					0	0	1	0	0	A	140188315	G	A	140188315	3	1	32	1	0	0	0	0	1	0	0	0	11572	1116	39	1	1545	1	PCDHA4	5	140188315	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	84009682	140188315	40726945	15	3042										
FAM71B	153745	broad.mit.edu	37	chr5	156589885	156589885	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	atgcggaccggtgggaagacGctttctgattcttgtccccc	12	12	2	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr5:156589885G>A	ENST00000302938.4	-	2	1486	c.1391C>T	c.(1390-1392)gCg>gTg	p.A464V		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	464						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGGAAGACGCTTTCTGATT	0.512													94	72					0	0	1	0	0	A	156589885	G	A	156589885	3	1	32	1	0	0	0	0	1	0	0	0	5642	1087	38	1	430	1	FAM71B	5	156589885	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	16401570	156589885	24325375	16	3043										
CDHR2	54825	broad.mit.edu	37	chr5	176016580	176016580	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ggctgcagttctccacaccgAaggaggaggtgggcgccaac	15	12	1	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr5:176016580A>G	ENST00000510636.1	+	24	3443	c.3169A>G	c.(3169-3171)Aag>Gag	p.K1057E	CDHR2_ENST00000261944.5_Missense_Mutation_p.K1057E|CDHR2_ENST00000506348.1_Missense_Mutation_p.K1057E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	1057	Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CTCCACACCGAAGGAGGAGGT	0.647													16	46					0	0	1	0	0	G	176016580	A	G	176016580	3	3	32	1	0	0	0	0	1	0	0	0	3141	247	9	4	3259	4	CDHR2	5	176016580	Missense_Mutation	SNP	A	TCGA-N8-A56S-01A-11D-A28R-08	19426695	176016580	4898680	17	3044										
PRSS35	167681	broad.mit.edu	37	chr6	84234378	84234378	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tgcctctggattcacgggaaCgatgccaattgtgcttacgg	12	10	2	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr6:84234378C>T	ENST00000536636.1	+	3	1563	c.1218C>T	c.(1216-1218)aaC>aaT	p.N406N	PRSS35_ENST00000369700.3_Silent_p.N406N	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	406	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		TTCACGGGAACGATGCCAATT	0.498													21	24					0	0	1	0	0	T	84234378	C	T	84234378	2	4	32	1	0	0	0	0	0	0	0	1	12672	535	19	1		1	PRSS35	6	84234378	Silent	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		84234378	86880689	18	3045										
C6orf70	0	broad.mit.edu	37	chr6	170176736	170176736	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ggaaaggacgctgcggtctcGccagcggcagaactacctgc	14	13	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr6:170176736G>A	ENST00000588451.1	+	15	1811	c.1298G>A	c.(1297-1299)cGc>cAc	p.R433H	C6orf70_ENST00000418781.3_Intron|C6orf70_ENST00000366773.3_Missense_Mutation_p.R569H|C6orf70_ENST00000366772.2_Intron|C6orf70_ENST00000392095.4_Missense_Mutation_p.R443H			Q5T6L9	CF070_HUMAN		569						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CTGCGGTCTCGCCAGCGGCAG	0.597													19	29					0	0	1	0	0	A	170176736	G	A	170176736	3	1	32	1	0	0	0	0	1	0	0	0	2385	1087	38	1	1768	1	C6orf70	6	170176736	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	85942358	170176736	938331	19	3046										
CARD11	84433	broad.mit.edu	37	chr7	2953022	2953022	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tgaagagcacgggccggcggCgctcgcagtagaaggcgcgt	18	11	0	3	rs141681466		TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr7:2953022C>T	ENST00000396946.4	-	22	3321	c.2918G>A	c.(2917-2919)cGc>cAc	p.R973H		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	973	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGGCCGGCGGCGCTCGCAGTA	0.647			Mis		DLBCL								49	71					0	0	1	0	0	T	2953022	C	T	2953022	3	4	32	1	0	0	0	0	1	0	0	0	2663	768	27	1	562	1	CARD11	7	2953022	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		2953022	156185641	20	3047										
HOXA13	3209	broad.mit.edu	37	chr7	27237844	27237844	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gtggttttcagtttgttgatGacttttttctctttaaccct	7	7	2	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr7:27237844G>A	ENST00000222753.4	-	2	1168	c.1140C>T	c.(1138-1140)gtC>gtT	p.V380V		NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	380					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						GTTTGTTGATGACTTTTTTCT	0.423			T	NUP98	AML								71	106					0	0	1	0	0	A	27237844	G	A	27237844	2	1	32	1	0	0	0	0	0	0	0	1	7331	1277	45	3		3	HOXA13	7	27237844	Silent	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	24284822	27237844	131900819	21	3048										
CAMK2B	816	broad.mit.edu	37	chr7	44268464	44268464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ccccgctgagagggggccctCggcttctggggttcctgaac	15	14	1	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr7:44268464C>T	ENST00000395749.2	-	19	1475	c.1399G>A	c.(1399-1401)Gag>Aag	p.E467K	CAMK2B_ENST00000346990.4_Intron|CAMK2B_ENST00000358707.3_Intron|CAMK2B_ENST00000489429.1_5'UTR|CAMK2B_ENST00000347193.4_Intron|CAMK2B_ENST00000258682.6_Intron|CAMK2B_ENST00000350811.3_Intron|CAMK2B_ENST00000353625.4_Intron|CAMK2B_ENST00000395747.2_Intron|CAMK2B_ENST00000502837.2_Intron|CAMK2B_ENST00000440254.2_Intron|CAMK2B_ENST00000457475.1_Intron	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	467					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						AGGGGGCCCTCGGCTTCTGGG	0.652													16	27					0	0	1	0	0	T	44268464	C	T	44268464	3	4	32	1	0	0	0	0	1	0	0	0	2618	893	31	1	621	1	CAMK2B	7	44268464	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	17030620	44268464	114870199	22	3049										
AKR1B15	441282	broad.mit.edu	37	chr7	134260173	134260173	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gtattcctttctatgataggCcatggaggagctggtggacg	14	7	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr7:134260173C>A	ENST00000457545.2	+	7	775	c.513_splice	c.e7-1	p.A172_splice	AKR1B15_ENST00000423958.1_Splice_Site_p.A144_splice	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	172							oxidoreductase activity	p.A190V(1)|p.A144V(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						CTATGATAGGCCATGGAGGAG	0.517													6	48					5.9392e-07	6.6519e-07	1	1	0	A	134260173	C	A	134260173	5	1	32	1	0	0	0	0	0	0	1	0	465	753	26	5	533	5	AKR1B15	7	134260173	Splice_Site	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	89991709	134260173	24878490	23	3050										
CHD7	55636	broad.mit.edu	37	chr8	61774882	61774882	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ggtgcctgttgtcaataaacGaaatgggaagaaggtaaacg	13	5	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr8:61774882G>A	ENST00000423902.2	+	36	8437	c.7958G>A	c.(7957-7959)cGa>cAa	p.R2653Q	CHD7_ENST00000524602.1_Missense_Mutation_p.R604Q	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2653					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GTCAATAAACGAAATGGGAAG	0.398													4	14					0	0	1	0	0	A	61774882	G	A	61774882	3	1	32	1	0	0	0	0	1	0	0	0	3352	1058	37	1	8096	1	CHD7	8	61774882	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08		61774882	84589140	24	3051										
ZER1	10444	broad.mit.edu	37	chr9	131515492	131515492	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gatgtggtcgtcggacaggtCcatgttgtagaggacgaggg	18	6	0	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr9:131515492C>A	ENST00000291900.2	-	4	1103	c.697G>T	c.(697-699)Gac>Tac	p.D233Y		NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	233					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						TCGGACAGGTCCATGTTGTAG	0.642													11	3					3.07112e-06	3.39439e-06	1	1	0	A	131515492	C	A	131515492	3	1	32	1	0	0	0	0	1	0	0	0	17682	855	30	2	1655	2	ZER1	9	131515492	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		131515492	9697939	25	3052										
CACNA1B	774	broad.mit.edu	37	chr9	140773541	140773541	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gatcctggccaccatcatcgCcaactgcatcgtgctggccc	9	17	1	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr9:140773541C>T	ENST00000371372.1	+	2	465	c.320C>T	c.(319-321)gCc>gTc	p.A107V	CACNA1B_ENST00000371355.4_Missense_Mutation_p.A107V|CACNA1B_ENST00000371357.1_Missense_Mutation_p.A107V|CACNA1B_ENST00000277551.2_Missense_Mutation_p.A107V|CACNA1B_ENST00000371363.1_Missense_Mutation_p.A107V|RP11-188C12.3_ENST00000371390.1_RNA|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	107					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ACCATCATCGCCAACTGCATC	0.647													8	39					0	0	1	0	0	T	140773541	C	T	140773541	3	4	32	1	0	0	0	0	1	0	0	0	2557	739	26	3	326	3	CACNA1B	9	140773541	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	9258049	140773541	439890	26	3053										
ASB13	79754	broad.mit.edu	37	chr10	5693326	5693326	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gtcgatgttgcgagcatccaCctcacgggaggaagaaacaa	12	10	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr10:5693326C>T	ENST00000357700.6	-	3	258	c.231_splice	c.e3-1	p.V78_splice	ASB13_ENST00000479033.1_Intron	NM_024701.3	NP_078977.2	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box containing 13	78					intracellular signal transduction		protein binding			NS(1)|endometrium(3)|lung(3)|ovary(1)	8				GBM - Glioblastoma multiforme(2;9.59e-09)		CGAGCATCCACCTCACGGGAG	0.567													14	18					0	0	1	0	0	T	5693326	C	T	5693326	5	4	32	1	0	0	0	0	0	0	1	0	1016	521	18	3	620	3	ASB13	10	5693326	Splice_Site	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		5693326	129841421	27	3054										
OGDHL	55753	broad.mit.edu	37	chr10	50955098	50955098	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	cttgccctgggcatctccacGgtagaactgctctgcctttg	10	14	2	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr10:50955098G>A	ENST00000374103.4	-	9	1229	c.1144C>T	c.(1144-1146)Cgt>Tgt	p.R382C	OGDHL_ENST00000419399.1_Missense_Mutation_p.R325C|OGDHL_ENST00000432695.1_Missense_Mutation_p.R173C	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	382					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						GCATCTCCACGGTAGAACTGC	0.642													44	76					0	0	1	0	0	A	50955098	G	A	50955098	3	1	32	1	0	0	0	0	1	0	0	0	10887	1116	39	1	1948	1	OGDHL	10	50955098	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	45261772	50955098	84579649	28	3055										
ZRANB1	54764	broad.mit.edu	37	chr10	126672148	126672148	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	aaatgatggctatggcaaccGaggtgctggtgctaatctca	12	8	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr10:126672148G>A	ENST00000359653.4	+	8	2170	c.1799G>A	c.(1798-1800)cGa>cAa	p.R600Q		NM_017580.2	NP_060050.2	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	600	TRAF-binding.				positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	23		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		TATGGCAACCGAGGTGCTGGT	0.468													24	44					0	0	1	0	0	A	126672148	G	A	126672148	3	1	32	1	0	0	0	0	1	0	0	0	18263	1058	37	1	1829	1	ZRANB1	10	126672148	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	75717050	126672148	8862599	29	3056										
GYLTL1B	120071	broad.mit.edu	37	chr11	45948052	45948052	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	aacaagcatgtggaattcttCcgcaatttctacctgacctt	6	11	2	1	rs142831797		TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr11:45948052C>A	ENST00000531526.1	+	9	1179	c.1068C>A	c.(1066-1068)ttC>ttA	p.F356L	GYLTL1B_ENST00000325468.5_Missense_Mutation_p.F356L|GYLTL1B_ENST00000536139.1_Missense_Mutation_p.F325L|GYLTL1B_ENST00000401752.1_Missense_Mutation_p.F356L|GYLTL1B_ENST00000529052.1_Missense_Mutation_p.F325L|GYLTL1B_ENST00000389968.3_Missense_Mutation_p.F83L	NM_152312.3	NP_689525.3	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	356					muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(35;0.226)		TGGAATTCTTCCGCAATTTCT	0.582													36	5					9.17885e-22	1.08595e-21	1	1	0	A	45948052	C	A	45948052	3	1	32	1	0	0	0	0	1	0	0	0	6947	854	30	2	1098	2	GYLTL1B	11	45948052	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		45948052	89058464	30	3057										
STX3	6809	broad.mit.edu	37	chr11	59559673	59559673	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gcagcaaagggcgaatccagCggcagctcgaaattagtatg	13	9	0	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr11:59559673C>T	ENST00000535361.1	+	6	998	c.451C>T	c.(451-453)Cgg>Tgg	p.R151W	STX3_ENST00000337979.4_Missense_Mutation_p.R151W|STX3_ENST00000437946.2_Missense_Mutation_p.R54W|STX3_ENST00000529177.1_Missense_Mutation_p.R151W|STX3_ENST00000300150.7_Missense_Mutation_p.R120W			Q13277	STX3_HUMAN	syntaxin 3	151					cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|skin(1)	13						GCGAATCCAGCGGCAGCTCGA	0.527													17	37					0	0	1	0	0	T	59559673	C	T	59559673	3	4	32	1	0	0	0	0	1	0	0	0	15401	759	27	1	473	1	STX3	11	59559673	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	13611621	59559673	75446843	31	3058										
ANO2	57101	broad.mit.edu	37	chr12	6031879	6031879	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gcccggggacctggcatcttGagacactgctgtccatgttt	12	12	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr12:6031879G>A	ENST00000546188.1	-	2	173	c.102C>T	c.(100-102)ctC>ctT	p.L34L	ANO2_ENST00000327087.8_Silent_p.L34L|ANO2_ENST00000356134.5_Silent_p.L34L			Q9NQ90	ANO2_HUMAN	anoctamin 2	38						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CTGGCATCTTGAGACACTGCT	0.662													6	6					0	0	1	0	0	A	6031879	G	A	6031879	2	1	32	1	0	0	0	0	0	0	0	1	691	1277	45	3		3	ANO2	12	6031879	Silent	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08		6031879	127820016	32	3059										
VWF	7450	broad.mit.edu	37	chr12	6101114	6101114	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tggtccccacaggagctcacGttgccatcacagtgccgggg	13	14	2	0	rs149847513	by1000genomes	TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr12:6101114G>A	ENST00000261405.5	-	38	6923	c.6669C>T	c.(6667-6669)aaC>aaT	p.N2223N		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2223	E2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AGGAGCTCACGTTGCCATCAC	0.552													24	28					0	0	1	0	0	A	6101114	G	A	6101114	2	1	32	1	0	0	0	0	0	0	0	1	17305	1136	40	1		1	VWF	12	6101114	Silent	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	69235	6101114	127750781	33	3060										
TRPV4	59341	broad.mit.edu	37	chr12	110234489	110234489	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tcctcatccgtcacctcccgCcggatgatgtgctgaaagat	9	14	2	3			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr12:110234489C>T	ENST00000418703.2	-	6	1267	c.1173G>A	c.(1171-1173)cgG>cgA	p.R391R	TRPV4_ENST00000541794.1_Silent_p.R344R|TRPV4_ENST00000544971.1_Intron|TRPV4_ENST00000536838.1_Silent_p.R357R|TRPV4_ENST00000392719.2_Silent_p.R344R|TRPV4_ENST00000346520.2_Intron|TRPV4_ENST00000537083.1_Intron|TRPV4_ENST00000261740.2_Silent_p.R391R	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	391					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						TCACCTCCCGCCGGATGATGT	0.622													28	43					0	0	1	0	0	T	110234489	C	T	110234489	2	4	32	1	0	0	0	0	0	0	0	1	16658	726	26	3		3	TRPV4	12	110234489	Silent	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	104133375	110234489	23617406	34	3061										
NID2	22795	broad.mit.edu	37	chr14	52521021	52521021	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tggaaagcccacactccaggGatccccaggttgcttagtct	10	13	1	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr14:52521021G>T	ENST00000216286.5	-	4	785	c.786C>A	c.(784-786)atC>atA	p.I262I	NID2_ENST00000541773.1_Silent_p.I209I	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	262	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ACACTCCAGGGATCCCCAGGT	0.483													24	5					3.6726e-16	4.2847e-16	1	1	0	T	52521021	G	T	52521021	2	4	32	1	0	0	0	0	0	0	0	1	10461	1164	41	2		2	NID2	14	52521021	Silent	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08		52521021	54828519	35	3062										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32928766	32928766	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tgaccaaagagactttggtgAaagttcaaaaagcgttttct	9	6	2	3			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr15:32928766A>G	ENST00000361627.3	+	12	2514	c.1792A>G	c.(1792-1794)Aaa>Gaa	p.K598E	ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.K409E|ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.K409E	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	598					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		GACTTTGGTGAAAGTTCAAAA	0.373													17	25					0	0	1	0	0	G	32928766	A	G	32928766	3	3	32	1	0	0	0	0	1	0	0	0	860	247	9	4	1861	4	ARHGAP11A	15	32928766	Missense_Mutation	SNP	A	TCGA-N8-A56S-01A-11D-A28R-08		32928766	69602626	36	3063										
DUOX2	50506	broad.mit.edu	37	chr15	45391874	45391874	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	acgtactggccaggacaacaGcagccatggcgatccagcgg	13	13	0	0			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr15:45391874G>A	ENST00000389039.6	-	25	3786	c.3401C>T	c.(3400-3402)gCt>gTt	p.A1134V	DUOX2_ENST00000603300.1_Missense_Mutation_p.A1134V			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1134	Ferric oxidoreductase.|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CAGGACAACAGCAGCCATGGC	0.557													38	63					0	0	1	0	0	A	45391874	G	A	45391874	3	1	32	1	0	0	0	0	1	0	0	0	4827	971	34	3	1285	3	DUOX2	15	45391874	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	12463108	45391874	57139518	37	3064										
CHRNB4	1143	broad.mit.edu	37	chr15	78923451	78923451	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	cgatgtcaggcaaccagatgCgctttgcagggatcctcagg	13	11	2	1	rs149832833	byFrequency	TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr15:78923451C>T	ENST00000261751.3	-	4	437	c.326G>A	c.(325-327)cGc>cAc	p.R109H	CHRNB4_ENST00000412074.2_Missense_Mutation_p.R109H|CHRNB4_ENST00000560511.1_5'UTR	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	109					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CAACCAGATGCGCTTTGCAGG	0.592													4	104					0	0	1	0	0	T	78923451	C	T	78923451	3	4	32	1	0	0	0	0	1	0	0	0	3415	768	27	1	1182	1	CHRNB4	15	78923451	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	33531577	78923451	23607941	38	3065										
IRX6	79190	broad.mit.edu	37	chr16	55362885	55362885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	agaagctgacttcctctcggCggagacaggcagccctaggt	13	12	1	3			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr16:55362885C>T	ENST00000290552.7	+	5	2327	c.995C>T	c.(994-996)gCg>gTg	p.A332V	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	332						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						TTCCTCTCGGCGGAGACAGGC	0.632													5	75					0	0	1	0	0	T	55362885	C	T	55362885	3	4	32	1	0	0	0	0	1	0	0	0	7891	768	27	1	1013	1	IRX6	16	55362885	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		55362885	34991868	39	3066										
RSPRY1	89970	broad.mit.edu	37	chr16	57238722	57238722	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tatctgccgagatgacagtgGaacagatgacagtgttgaca	12	7	1	5			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr16:57238722G>A	ENST00000537866.1	+	2	1025	c.152G>A	c.(151-153)gGa>gAa	p.G51E	RSPRY1_ENST00000394420.4_Missense_Mutation_p.G51E			Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	51						extracellular region	zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|urinary_tract(3)	27						GATGACAGTGGAACAGATGAC	0.552													93	103					0	0	1	0	0	A	57238722	G	A	57238722	3	1	32	1	0	0	0	0	1	0	0	0	13764	1174	41	3	154	3	RSPRY1	16	57238722	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	1875837	57238722	33116031	40	3067										
POLR2A	5430	broad.mit.edu	37	chr17	7417153	7417153	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	cccagagtataccccaacctCtcccaagtactcacctacca	3	19	2	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr17:7417153C>T	ENST00000322644.6	+	29	5969	c.5570C>T	c.(5569-5571)tCt>tTt	p.S1857F		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1857	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ACCCCAACCTCTCCCAAGTAC	0.567													104	154					0	0	1	0	0	T	7417153	C	T	7417153	3	4	32	1	0	0	0	0	1	0	0	0	12261	913	32	3	5684	3	POLR2A	17	7417153	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		7417153	73778057	41	3068										
TP53	7157	broad.mit.edu	37	chr17	7579389	7579389	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gctgccctggtaggttttctGggaagggacagaagatgaca	15	7	1	3			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr17:7579389G>A	ENST00000420246.2	-	4	430	c.298C>T	c.(298-300)Cag>Tag	p.Q100*	TP53_ENST00000445888.2_Nonsense_Mutation_p.Q100*|TP53_ENST00000413465.2_Nonsense_Mutation_p.Q100*|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q100*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q100*|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q100*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	100	Interaction with HIPK1 (By similarity).|Interaction with WWOX.		Q -> R (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q100*(12)|p.0?(8)|p.Q100fs*37(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.W91fs*13(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TAGGTTTTCTGGGAAGGGACA	0.652		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			71	24					0	0	1	0	0	A	7579389	G	A	7579389	4	1	32	1	0	0	0	0	0	1	0	0	16441	1357	47	3	1004	3	TP53	17	7579389	Nonsense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	162236	7579389	73615821	42	3069										
BPTF	2186	broad.mit.edu	37	chr17	65916138	65916138	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	taaatcaccatagaaacatcCgaaactgaaatcacaacaac	3	11	2	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr17:65916138C>T	ENST00000321892.4	+	15	5875	c.5814C>T	c.(5812-5814)tcC>tcT	p.S1938S	BPTF_ENST00000335221.5_Silent_p.S1938S|BPTF_ENST00000424123.3_Silent_p.S1799S|BPTF_ENST00000306378.6_Silent_p.S1812S			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1938					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TAGAAACATCCGAAACTGAAA	0.343													42	14					0	0	1	0	0	T	65916138	C	T	65916138	2	4	32	1	0	0	0	0	0	0	0	1	1497	639	23	1		1	BPTF	17	65916138	Silent	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	58336749	65916138	15279072	43	3070										
HGS	9146	broad.mit.edu	37	chr17	79653378	79653378	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	aattccatcaagaagaaagtCaacgacaagaacccacacgt	6	11	2	3			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr17:79653378C>T	ENST00000329138.4	+	3	294	c.159C>T	c.(157-159)gtC>gtT	p.V53V		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	53	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			AGAAGAAAGTCAACGACAAGA	0.478													62	12					0	0	1	0	0	T	79653378	C	T	79653378	2	4	32	1	0	0	0	0	0	0	0	1	7127	813	29	3		3	HGS	17	79653378	Silent	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	13737240	79653378	1541832	44	3071										
ZSWIM4	65249	broad.mit.edu	37	chr19	13941049	13941049	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tgcagaactggtattccttaTtcacaccagtggaggcggct	11	10	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr19:13941049T>C	ENST00000254323.2	+	13	2344	c.2155T>C	c.(2155-2157)Ttc>Ctc	p.F719L	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.F553L	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	719							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GTATTCCTTATTCACACCAGT	0.602													34	11					0	0	1	0	0	C	13941049	T	C	13941049	3	2	32	1	0	0	0	0	1	0	0	0	18282	1493	52	4	2205	4	ZSWIM4	19	13941049	Missense_Mutation	SNP	T	TCGA-N8-A56S-01A-11D-A28R-08		13941049	45187934	45	3072										
NWD1	284434	broad.mit.edu	37	chr19	16872832	16872832	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gagcgctacctgtcaggatcCgagagagccaagaggcatgg	15	10	1	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr19:16872832C>T	ENST00000524140.2	+	8	2434	c.2016C>T	c.(2014-2016)tcC>tcT	p.S672S	NWD1_ENST00000379808.3_Silent_p.S672S|NWD1_ENST00000552788.1_Silent_p.S672S|NWD1_ENST00000523826.1_Silent_p.S466S|NWD1_ENST00000339803.6_Silent_p.S537S|NWD1_ENST00000549814.1_Silent_p.S672S	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	672							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGTCAGGATCCGAGAGAGCCA	0.577													13	38					0	0	1	0	0	T	16872832	C	T	16872832	2	4	32	1	0	0	0	0	0	0	0	1	10828	639	23	1		1	NWD1	19	16872832	Silent	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	2931783	16872832	42256151	46	3073										
LPIN3	64900	broad.mit.edu	37	chr20	39981249	39981249	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tctgcctctgtgcccagagaAattcaaccagcacagcgtct	8	14	4	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr20:39981249A>T	ENST00000373257.3	+	10	1458	c.1367A>T	c.(1366-1368)aAa>aTa	p.K456I		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	456					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				TGCCCAGAGAAATTCAACCAG	0.567													14	594					0	0	1	0	0	T	39981249	A	T	39981249	3	4	32	1	0	0	0	0	1	0	0	0	8964	14	1	4	1401	4	LPIN3	20	39981249	Missense_Mutation	SNP	A	TCGA-N8-A56S-01A-11D-A28R-08		39981249	23044271	47	3074										
LAMA5	3911	broad.mit.edu	37	chr20	60885521	60885521	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gggaagaacaggcccgcctcCagggggcccaagatgcaggg	17	12	0	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr20:60885521C>A	ENST00000252999.3	-	76	10620	c.10554G>T	c.(10552-10554)ctG>ctT	p.L3518L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3518					angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCCCGCCTCCAGGGGGCCCA	0.682													22	72					7.41877e-09	8.42131e-09	1	1	0	A	60885521	C	A	60885521	2	1	32	1	0	0	0	0	0	0	0	1	8647	581	21	5		5	LAMA5	20	60885521	Silent	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	20904272	60885521	2139999	48	3075										
BAGE2	85319	broad.mit.edu	37	chr21	11048257	11048257	+	RNA	DEL	C	C	-													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tttctttaaacactcttctgCccccaaagattgggcccctg							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr21:11048257delC	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACTCTTCTGCCCCCAAAGAT	0.318													2	4	---	---	---	---						-	11048257	C	-	11048257	6	5	32	0	1	1	0	1	0	0	0	0	1290	754	26	0		0	BAGE2	21	11048257	RNA	DEL	C	TCGA-N8-A56S-01A-11D-A28R-08		11048257	37081638	49	3076										
BAGE2	85319	broad.mit.edu	37	chr21	11066526	11066532	+	RNA	DEL	ATAACAT	ATAACAT	-													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tttatttaggttgtaagaaaAtaacatataaccaggcacgg					rs79906709	by1000genomes	TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr21:11066526_11066532delATAACAT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTGTAAGAAAATAACATATAAccaggc	0.391													3	6	---	---	---	---						-	11066532	ATAACAT	-	11066526	6	5	32	0	1	1	0	1	0	0	0	0	1290	116	4	0		0	BAGE2	21	11066526	RNA	DEL	ATAACAT	TCGA-N8-A56S-01A-11D-A28R-08	18269	11066526	37063369	50	3077										
U2AF1	7307	broad.mit.edu	37	chr21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tcggtttattgtgcaaccgaGagcacctgtctccatgacga	10	11	1	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr21:44524456G>A	ENST00000291552.4	-	2	193	c.101C>T	c.(100-102)tCt>tTt	p.S34F	U2AF1_ENST00000486519.1_5'UTR|U2AF1_ENST00000459639.1_5'UTR|U2AF1_ENST00000380276.2_Missense_Mutation_p.S34F|U2AF1_ENST00000398137.1_5'UTR	NM_006758.2	NP_006749.1	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	34					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding	p.S34F(45)|p.S34Y(12)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						GTGCAACCGAGAGCACCTGTC	0.358			Mis		"CLL, MDS"								11	30					0	0	1	0	0	A	44524456	G	A	44524456	3	1	32	1	0	0	0	0	1	0	0	0	16881	942	33	3	720	3	U2AF1	21	44524456	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	33457930	44524456	3605439	51	3078										
CSF2RB	1439	broad.mit.edu	37	chr22	37325831	37325831	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gcaagtggagcccagaggttTgctgggactcccagccaggt	15	11	0	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chr22:37325831T>C	ENST00000262825.5	+	6	917	c.700T>C	c.(700-702)Tgc>Cgc	p.C234R	CSF2RB_ENST00000403662.3_Missense_Mutation_p.C234R|CSF2RB_ENST00000406230.1_Missense_Mutation_p.C234R|CSF2RB_ENST00000536485.1_Missense_Mutation_p.C175R	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	234					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCCAGAGGTTTGCTGGGACTC	0.657													18	19					0	0	1	0	0	C	37325831	T	C	37325831	3	2	32	1	0	0	0	0	1	0	0	0	3960	1812	63	4	718	4	CSF2RB	22	37325831	Missense_Mutation	SNP	T	TCGA-N8-A56S-01A-11D-A28R-08		37325831	13978735	52	3079										
ASB9	140462	broad.mit.edu	37	chrX	15272961	15272961	+	Missense_Mutation	SNP	C	C	A													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gccgtgatgatgttcacagcCcacccctgaaggaggggaaa							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:15272961C>A	ENST00000546332.1	-	4	663	c.180G>T	c.(178-180)tgG>tgT	p.W60C	ASB9_ENST00000380483.3_Missense_Mutation_p.W60C|ASB9_ENST00000380488.4_Missense_Mutation_p.W60C|ASB9_ENST00000380485.3_Missense_Mutation_p.W60C|ASB9_ENST00000473862.1_5'UTR	NM_001168531.1	NP_001162003.1	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box containing 9	60					intracellular signal transduction					breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(10)	15	Hepatocellular(33;0.183)					TGTTCACAGCCCACCCCTGAA	0.502													5	123					0.014758	0.0149358	1	1	0	A	15272961	C	A	15272961	3	1	32	1	0	0	0	0	1	0	0	0	1029	624	22	5	753	5	ASB9	23	15272961	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08		15272961	139997599	53	3080	13	2								
ASB9	140462	broad.mit.edu	37	chrX	15272962	15272962	+	Missense_Mutation	SNP	C	C	A													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	ccgtgatgatgttcacagccCacccctgaaggaggggaaac							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:15272962C>A	ENST00000546332.1	-	4	662	c.179G>T	c.(178-180)tGg>tTg	p.W60L	ASB9_ENST00000380483.3_Missense_Mutation_p.W60L|ASB9_ENST00000380488.4_Missense_Mutation_p.W60L|ASB9_ENST00000380485.3_Missense_Mutation_p.W60L|ASB9_ENST00000473862.1_5'UTR	NM_001168531.1	NP_001162003.1	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box containing 9	60					intracellular signal transduction					breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(10)	15	Hepatocellular(33;0.183)					GTTCACAGCCCACCCCTGAAG	0.502													5	122					0.014758	0.0149358	1	1	0	A	15272962	C	A	15272962	3	1	32	1	0	0	0	0	1	0	0	0	1029	595	21	5	754	5	ASB9	23	15272962	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	1	15272962	139997598	54	3081	13	2								
NHS	4810	broad.mit.edu	37	chrX	17710478	17710478	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	accggagccggagcgatcgcCgagagcaaagagcagctgcc	15	13	0	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:17710478C>T	ENST00000380060.3	+	3	1080	c.742C>T	c.(742-744)Cga>Tga	p.R248*	NHS_ENST00000398097.3_Nonsense_Mutation_p.R71*	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	248						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					GAGCGATCGCCGAGAGCAAAG	0.532													33	62					0	0	1	0	0	T	17710478	C	T	17710478	4	4	32	1	0	0	0	0	0	1	0	0	10457	644	23	1	790	1	NHS	23	17710478	Nonsense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	2437516	17710478	137560082	55	3082										
MAGEB1	4112	broad.mit.edu	37	chrX	30268692	30268692	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	agacccagggtctcaaggttGctcacgccactgcagcagag	12	13	2	2	rs2856741		TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:30268692G>T	ENST00000378981.3	+	4	403	c.82G>T	c.(82-84)Gct>Tct	p.A28S	MAGEB1_ENST00000397548.2_Missense_Mutation_p.A28S|MAGEB1_ENST00000397550.1_Missense_Mutation_p.A28S	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	28				A -> R (in Ref. 1; CAA57889).						NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						TCTCAAGGTTGCTCACGCCAC	0.602													7	24					0.00198382	0.00210938	1	1	0	T	30268692	G	T	30268692	3	4	32	1	0	0	0	0	1	0	0	0	9221	1319	46	5	84	5	MAGEB1	23	30268692	Missense_Mutation	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	12558214	30268692	125001868	56	3083										
CLCN5	1184	broad.mit.edu	37	chrX	49845343	49845343	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tctcttgtcaaggtgtttgcGccttatgcctgtggctctgg	12	10	3	0	rs140312372	byFrequency	TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:49845343G>A	ENST00000376088.3	+	8	1337	c.696G>A	c.(694-696)gcG>gcA	p.A232A	CLCN5_ENST00000376091.3_Silent_p.A232A|CLCN5_ENST00000376108.3_Silent_p.A162A|CLCN5_ENST00000307367.2_Silent_p.A162A	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	162					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					AGGTGTTTGCGCCTTATGCCT	0.408													20	43					0	0	1	0	0	A	49845343	G	A	49845343	2	1	32	1	0	0	0	0	0	0	0	1	3489	1074	38	1		1	CLCN5	23	49845343	Silent	SNP	G	TCGA-N8-A56S-01A-11D-A28R-08	19576651	49845343	105425217	57	3084										
MAGEC1	9947	broad.mit.edu	37	chrX	140993983	140993983	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gtacttttgagggttttgccCagtcttctctccagattcct	8	11	2	2			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:140993983C>A	ENST00000285879.4	+	4	1079	c.793C>A	c.(793-795)Cag>Aag	p.Q265K	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	265							protein binding	p.Q265K(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GGGTTTTGCCCAGTCTTCTCT	0.488										HNSCC(15;0.026)			5	164					0.014758	0.0149358	1	1	0	A	140993983	C	A	140993983	3	1	32	1	0	0	0	0	1	0	0	0	9229	595	21	5	799	5	MAGEC1	23	140993983	Missense_Mutation	SNP	C	TCGA-N8-A56S-01A-11D-A28R-08	91148640	140993983	14276577	58	3085										
SLITRK2	84631	broad.mit.edu	37	chrX	144906237	144906237	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	tattgctgagcgagtcaaggAacttcccagcgcaggcctag	12	11	1	1			TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:144906237A>G	ENST00000370490.1	+	1	6549	c.2294A>G	c.(2293-2295)gAa>gGa	p.E765G	SLITRK2_ENST00000447897.2_Missense_Mutation_p.E765G|SLITRK2_ENST00000434188.2_Missense_Mutation_p.E765G|SLITRK2_ENST00000413937.2_Missense_Mutation_p.E765G|SLITRK2_ENST00000428560.2_Missense_Mutation_p.E765G			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	765						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CGAGTCAAGGAACTTCCCAGC	0.478													20	267					0	0	1	0	0	G	144906237	A	G	144906237	3	3	32	1	0	0	0	0	1	0	0	0	14796	246	9	4	2296	4	SLITRK2	23	144906237	Missense_Mutation	SNP	A	TCGA-N8-A56S-01A-11D-A28R-08	3912254	144906237	10364323	59	3086										
SRPK3	26576	broad.mit.edu	37	chrX	153050878	153050883	+	In_Frame_Del	DEL	CACAGT	CACAGT	-													0.101694915254237	6	1	1.45746931866272	4.1294964028777	1.29046762589928	0.0800865800865801	0.651583710407241	0	gtggcccctagagcaggccaCacagttcagcgcctttctgc							TCGA-N8-A56S-01A-11D-A28R-08	TCGA-N8-A56S-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86211ee6-0559-4825-a102-ed909f5328ee	cf639b94-ef71-448e-80fe-eeb0283bd015	g.chrX:153050878_153050883delCACAGT	ENST00000489426.1	+	21	4174_4179	c.1808_1813delCACAGT	c.(1807-1815)atc>a	p.TQF603del	SRPK3_ENST00000393786.3_In_Frame_Del_p.TQF502del|SRPK3_ENST00000370101.3_In_Frame_Del_p.TQF536del|SRPK3_ENST00000370100.1_In_Frame_Del_p.TQF461del|SRPK3_ENST00000370104.1_In_Frame_Del_p.TQF535del|SRPK3_ENST00000370108.3_In_Frame_Del_p.TQF503del			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	536					cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGCAGGCCACACAGTTCAGCGCCTT	0.626													49	97	---	---	---	---						-	153050883	CACAGT	-	153050878	7	5	32	1	0	1	0	1	0	0	0	0	15216	478	17	0	1665	0	SRPK3	23	153050878	In_Frame_Del	DEL	CACAGT	TCGA-N8-A56S-01A-11D-A28R-08	8144641	153050878	2219682	60	3087										
FCN3	8547	broad.mit.edu	37	chr1	27697155	27697155	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cctcaccgaggaggcggaagGtcgcatagtgggcgaaagta	16	9	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:27697155G>T	ENST00000270879.4	-	7	595	c.590C>A	c.(589-591)aCc>aAc	p.T197N	FCN3_ENST00000354982.2_Missense_Mutation_p.T186N	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	197	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GAGGCGGAAGGTCGCATAGTG	0.577													5	120					0.0215528	0.0221627	1	1	0	T	27697155	G	T	27697155	3	4	33	1	0	0	0	0	1	0	0	0	5825	1261	44	5	317	5	FCN3	1	27697155	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		27697155	221553466	1	3088										
PDE4DIP	9659	broad.mit.edu	37	chr1	145014238	145014238	+	Frame_Shift_Del	DEL	C	C	-													0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gggtgttagcatccttgcttCccccaccagcaccacacagc							TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:145014238delC	ENST00000493130.2	-	4	465	c.304delG	c.(304-306)aafs	p.E102fs	PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369348.3_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATCCTTGCTTCCCCCACCAGC	0.443			T	PDGFRB	MPD								2	4	---	---	---	---						-	145014238	C	-	145014238	7	5	33	1	0	1	0	1	0	0	0	0	11689	870	30	0		0	PDE4DIP	1	145014238	Frame_Shift_Del	DEL	C	TCGA-N9-A4PZ-01A-22D-A28R-08	117317083	145014238	104236383	2	3089										
NTRK1	4914	broad.mit.edu	37	chr1	156843598	156843598	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cggcagccaatgagaccgtgCggcacgggtgtctgcgcctc	15	14	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:156843598C>T	ENST00000368196.3	+	8	1144	c.1024C>T	c.(1024-1026)Cgg>Tgg	p.R342W	NTRK1_ENST00000524377.1_Missense_Mutation_p.R342W|NTRK1_ENST00000392302.2_Missense_Mutation_p.R312W|NTRK1_ENST00000358660.3_Missense_Mutation_p.R342W	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	342	Ig-like C2-type 2.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGAGACCGTGCGGCACGGGTG	0.632			T	"TPM3, TPR, TFG"	papillary thyroid					TSP Lung(10;0.080)			23	17					0	0	1	0	0	T	156843598	C	T	156843598	3	4	33	1	0	0	0	0	1	0	0	0	10753	759	27	1	1184	1	NTRK1	1	156843598	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	11829360	156843598	92407023	3	3090										
FAM5B	0	broad.mit.edu	37	chr1	177247778	177247778	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	atctcccagttctgggccatGgacaccagccttcagcaccg	9	16	3	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:177247778G>A	ENST00000361539.4	+	7	1404	c.1092G>A	c.(1090-1092)atG>atA	p.M364I	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		364						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TCTGGGCCATGGACACCAGCC	0.567													15	579					0	0	1	0	0	A	177247778	G	A	177247778	3	1	33	1	0	0	0	0	1	0	0	0	5627	1348	47	3	1114	3	FAM5B	1	177247778	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	20404180	177247778	72002843	4	3091										
CRB1	23418	broad.mit.edu	37	chr1	197411423	197411423	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gcgagcgctgcgaggtggacGtaagcagcctctccttttat	13	11	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:197411423G>T	ENST00000367400.3	+	11	4140		c.e11+1		RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000544212.1_Splice_Site|CRB1_ENST00000538660.1_Splice_Site|CRB1_ENST00000367399.2_Splice_Site|CRB1_ENST00000535699.1_Splice_Site|CRB1_ENST00000367397.1_3'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)						cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CGAGGTGGACGTAAGCAGCCT	0.478													9	196					0.000274275	0.000296	1	1	0	T	197411423	G	T	197411423	5	4	33	1	0	0	0	0	0	0	1	0	3871	1159	40	5	4048	5	CRB1	1	197411423	Splice_Site	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	20163645	197411423	51839198	5	3092										
CACNA1S	779	broad.mit.edu	37	chr1	201047049	201047049	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggaggcggatgcagcggagcAcggagatgcccaggggtgtc	20	9	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:201047049A>G	ENST00000362061.3	-	11	1803	c.1577T>C	c.(1576-1578)gTg>gCg	p.V526A	CACNA1S_ENST00000367338.3_Missense_Mutation_p.V526A	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	526					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCAGCGGAGCACGGAGATGCC	0.627													5	91					0	0	1	0	0	G	201047049	A	G	201047049	3	3	33	1	0	0	0	0	1	0	0	0	2565	159	6	4	4180	4	CACNA1S	1	201047049	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	3635626	201047049	48203572	6	3093										
ADIPOR1	51094	broad.mit.edu	37	chr1	202915580	202915580	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cactcaccaagcagatgggtCcagatgttgccagtttctgt	10	11	2	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:202915580C>T	ENST00000340990.5	-	4	715	c.417G>A	c.(415-417)tgG>tgA	p.W139*	ADIPOR1_ENST00000367254.3_Nonsense_Mutation_p.W139*|ADIPOR1_ENST00000436244.1_Nonsense_Mutation_p.W139*	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	139					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			GCAGATGGGTCCAGATGTTGC	0.478													34	145					0	0	1	0	0	T	202915580	C	T	202915580	4	4	33	1	0	0	0	0	0	1	0	0	317	856	30	3	730	3	ADIPOR1	1	202915580	Nonsense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	1868531	202915580	46335041	7	3094										
GALNT2	2590	broad.mit.edu	37	chr1	230415077	230415077	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	acagatcgagggcaactccaAgctgaggcacgtgggcagca	14	11	0	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:230415077A>C	ENST00000366672.4	+	16	1661	c.1589A>C	c.(1588-1590)aAg>aCg	p.K530T	GALNT2_ENST00000543760.1_Missense_Mutation_p.K492T|GALNT2_ENST00000485438.1_3'UTR	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	530	Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GGCAACTCCAAGCTGAGGCAC	0.582													33	40					0	0	1	0	0	C	230415077	A	C	230415077	3	2	33	1	0	0	0	0	1	0	0	0	6252	72	3	4	1651	4	GALNT2	1	230415077	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	27499497	230415077	18835544	8	3095										
TTC30B	150737	broad.mit.edu	37	chr2	178416032	178416032	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggatgttatcataatgcttcTtgactatgggttcatagaaa	9	5	3	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:178416032T>C	ENST00000408939.2	-	1	1710	c.1460A>G	c.(1459-1461)aAg>aGg	p.K487R		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	487					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			ATAATGCTTCTTGACTATGGG	0.383													23	84					0	0	1	0	0	C	178416032	T	C	178416032	3	2	33	1	0	0	0	0	1	0	0	0	16760	1609	56	4	541	4	TTC30B	2	178416032	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08		178416032	64783341	9	3096										
ILKAP	80895	broad.mit.edu	37	chr2	239103471	239103471	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tcagtactgctggccggaggGaggtcatcaaagagcagggg	17	8	3	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:239103471G>A	ENST00000254654.3	-	2	271	c.96C>T	c.(94-96)ctC>ctT	p.L32L	ILKAP_ENST00000490837.1_5'UTR	NM_030768.2	NP_110395.1	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated serine/threonine phosphatase	32						cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		TGGCCGGAGGGAGGTCATCAA	0.473													13	39					0	0	1	0	0	A	239103471	G	A	239103471	2	1	33	1	0	0	0	0	0	0	0	1	7757	1161	41	3		3	ILKAP	2	239103471	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	60687439	239103471	4095902	10	3097										
PASK	23178	broad.mit.edu	37	chr2	242062240	242062240	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ctgtacttttgggagtactcGccctcacaggccgccaaccc	9	16	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:242062240G>A	ENST00000403638.3	-	12	3070	c.2979C>T	c.(2977-2979)ggC>ggT	p.G993G	PASK_ENST00000539818.1_Silent_p.G777G|PASK_ENST00000405260.1_Silent_p.G993G|PASK_ENST00000544142.1_Silent_p.G807G|PASK_ENST00000234040.4_Silent_p.G993G|PASK_ENST00000358649.4_Silent_p.G993G	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	993					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GGGAGTACTCGCCCTCACAGG	0.587													26	71					0	0	1	0	0	A	242062240	G	A	242062240	2	1	33	1	0	0	0	0	0	0	0	1	11518	1074	38	1		1	PASK	2	242062240	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	2958769	242062240	1137133	11	3098										
ROBO2	6092	broad.mit.edu	37	chr3	77595594	77595594	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cccacagccagctgttttttGgcagaaagaaggcagccagg	12	11	0	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:77595594G>A	ENST00000461745.1	+	7	1940	c.1040G>A	c.(1039-1041)tGg>tAg	p.W347*	ROBO2_ENST00000332191.8_Nonsense_Mutation_p.W347*|ROBO2_ENST00000487694.3_Nonsense_Mutation_p.W363*	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	347	Ig-like C2-type 4.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GCTGTTTTTTGGCAGAAAGAA	0.478													27	179					0	0	1	0	0	A	77595594	G	A	77595594	4	1	33	1	0	0	0	0	0	1	0	0	13565	1357	47	3	1068	3	ROBO2	3	77595594	Nonsense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		77595594	120426836	12	3099										
CASR	846	broad.mit.edu	37	chr3	122003445	122003445	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gcaccgcagctcacgctttcAaggtggctgcccgggccacg	13	16	2	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:122003445A>C	ENST00000498619.1	+	7	3112	c.2674A>C	c.(2674-2676)Aag>Cag	p.K892Q	CASR_ENST00000296154.5_Missense_Mutation_p.K882Q|CASR_ENST00000490131.1_Missense_Mutation_p.K882Q	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	882	Interaction with RNF19A.				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCACGCTTTCAAGGTGGCTGC	0.622													28	37					0	0	1	0	0	C	122003445	A	C	122003445	3	2	33	1	0	0	0	0	1	0	0	0	2700	131	5	4	2696	4	CASR	3	122003445	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	44407851	122003445	76018985	13	3100										
PIK3CA	5290	broad.mit.edu	37	chr3	178916957	178916957	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tgaagaaaagatcctcaatcGagaaattggtatgatacaat	8	5	1	5			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:178916957G>T	ENST00000263967.3	+	2	501	c.344G>T	c.(343-345)cGa>cTa	p.R115L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	115					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R115L(3)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCCTCAATCGAGAAATTGGT	0.333		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	36					1.1804e-14	1.36876e-14	1	1	0	T	178916957	G	T	178916957	3	4	33	1	0	0	0	0	1	0	0	0	11960	1058	37	2	346	2	PIK3CA	3	178916957	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	56913512	178916957	19105473	14	3101										
PCYT1A	5130	broad.mit.edu	37	chr3	195974349	195974349	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cgctcattctcgttcatcacCgtgaagcctttgaagttgtg	9	11	4	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:195974349C>T	ENST00000292823.2	-	6	547	c.375G>A	c.(373-375)acG>acA	p.T125T	PCYT1A_ENST00000419333.1_Silent_p.T125T|PCYT1A_ENST00000431016.1_Silent_p.T125T|PCYT1A_ENST00000491544.1_5'UTR	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	125	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CGTTCATCACCGTGAAGCCTT	0.537													30	106					0	0	1	0	0	T	195974349	C	T	195974349	2	4	33	1	0	0	0	0	0	0	0	1	11656	639	23	1		1	PCYT1A	3	195974349	Silent	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	17057392	195974349	2048081	15	3102										
CCDC158	339965	broad.mit.edu	37	chr4	77290771	77290771	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tccttctcccttttgtgtagAtcagcctaaaaaaagagagg	8	9	2	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr4:77290771A>G	ENST00000388914.3	-	10	1307	c.1155T>C	c.(1153-1155)gaT>gaC	p.D385D		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	385										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TTTTGTGTAGATCAGCCTAAA	0.408													4	60					0	0	1	0	0	G	77290771	A	G	77290771	2	3	33	1	0	0	0	0	0	0	0	1	2809	330	12	4		4	CCDC158	4	77290771	Silent	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08		77290771	113863505	16	3103										
PRDM8	56978	broad.mit.edu	37	chr4	81123237	81123237	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gaccacgggggcggcggcggCggtggcaaagaccagcagca	19	12	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr4:81123237C>T	ENST00000339711.4	+	10	1852	c.621C>T	c.(619-621)ggC>ggT	p.G207G	PRDM8_ENST00000504452.1_Silent_p.G207G|PRDM8_ENST00000415738.2_Silent_p.G207G	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	207	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcggcggcggcggtggcaaag	0.657											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	88					0	0	1	0	0	T	81123237	C	T	81123237	2	4	33	1	0	0	0	0	0	0	0	1	12513	755	27	1		1	PRDM8	4	81123237	Silent	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	3832466	81123237	110031039	17	3104										
C5orf38	153571	broad.mit.edu	37	chr5	2752842	2752842	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	acgggcaggagctcaggttgGcgccgccggtgcagtgggca	19	11	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:2752842G>T	ENST00000515640.1	+	2	326	c.307G>T	c.(307-309)Gcg>Tcg	p.A103S	C5orf38_ENST00000505778.1_Missense_Mutation_p.A103S|C5orf38_ENST00000457752.2_Intron|C5orf38_ENST00000334000.3_Missense_Mutation_p.A103S|C5orf38_ENST00000397835.4_Missense_Mutation_p.A103S|IRX2_ENST00000502957.1_5'UTR			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	103						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		GCTCAGGTTGGCGCCGCCGGT	0.637													58	63					1.64591e-14	1.88847e-14	1	1	0	T	2752842	G	T	2752842	3	4	33	1	0	0	0	0	1	0	0	0	2311	1203	42	5	313	5	C5orf38	5	2752842	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		2752842	178162418	18	3105										
PRLR	5618	broad.mit.edu	37	chr5	35084594	35084594	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	atgtaagtcacgtccacataAagttcatccgagaaactgct	7	10	2	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:35084594A>C	ENST00000382002.5	-	5	777	c.351T>G	c.(349-351)ctT>ctG	p.L117L	PRLR_ENST00000231423.3_Silent_p.L117L|PRLR_ENST00000348262.3_Silent_p.L117L|PRLR_ENST00000310101.5_Silent_p.L117L|PRLR_ENST00000397391.3_Silent_p.L46L|PRLR_ENST00000513753.1_Silent_p.L117L|PRLR_ENST00000542609.1_Silent_p.L117L|PRLR_ENST00000511486.1_Intron|PRLR_ENST00000342362.5_Intron|PRLR_ENST00000509934.1_5'UTR	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	117	Fibronectin type-III 1.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CGTCCACATAAAGTTCATCCG	0.453													4	190					0	0	1	0	0	C	35084594	A	C	35084594	2	2	33	1	0	0	0	0	0	0	0	1	12582	1	1	4		4	PRLR	5	35084594	Silent	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	32331752	35084594	145830666	19	3106										
ZFYVE16	9765	broad.mit.edu	37	chr5	79734554	79734554	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	aacccagcacagcagataccGttgttccaatcacttgtgct	7	13	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:79734554G>A	ENST00000338008.5	+	3	2230	c.2050G>A	c.(2050-2052)Gtt>Att	p.V684I	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.V684I|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.V684I	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	684					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AGCAGATACCGTTGTTCCAAT	0.398													11	77					0	0	1	0	0	A	79734554	G	A	79734554	3	1	33	1	0	0	0	0	1	0	0	0	17721	1145	40	1	2056	1	ZFYVE16	5	79734554	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	44649960	79734554	101180706	20	3107										
ARSK	153642	broad.mit.edu	37	chr5	94891003	94891003	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	atgctactgctgtgggtgtcGgtggtcgcagccttggcgct	16	10	0	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:94891003G>C	ENST00000380009.4	+	1	226	c.21G>C	c.(19-21)tcG>tcC	p.S7S	ARSK_ENST00000504763.1_Silent_p.S7S	NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	7						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TGTGGGTGTCGGTGGTCGCAG	0.692													3	11					0	0	1	0	0	C	94891003	G	C	94891003	2	2	33	1	0	0	0	0	0	0	0	1	995	1103	39	5		5	ARSK	5	94891003	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	15156449	94891003	86024257	21	3108										
PCDHGA7	0	broad.mit.edu	37	chr5	140764737	140764737	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cagacctattcccatgaggtCtccctcaccgcggactctcg	8	17	3	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:140764737C>G	ENST00000518325.1	+	1	2271	c.2271C>G	c.(2269-2271)gtC>gtG	p.V757V	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCATGAGGTCTCCCTCACCG	0.562													90	33					0	0	1	0	0	G	140764737	C	G	140764737	2	3	33	1	0	0	0	0	0	0	0	1	11605	900	32	2		2	PCDHGA7	5	140764737	Silent	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	45873734	140764737	40150523	22	3109										
FIG4	9896	broad.mit.edu	37	chr6	110081456	110081456	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tttaatttttgataaaggaaCgagagaaaagaaagcatgaa	9	2	0	4			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr6:110081456C>G	ENST00000230124.3	+	11	1265	c.1141C>G	c.(1141-1143)Cga>Gga	p.R381G	FIG4_ENST00000441478.2_Missense_Mutation_p.R104G	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	381	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GATAAAGGAACGAGAGAAAAG	0.333													11	44					0	0	1	0	0	G	110081456	C	G	110081456	3	3	33	1	0	0	0	0	1	0	0	0	5920	528	19	5	1183	5	FIG4	6	110081456	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08		110081456	61033611	23	3110										
REV3L	5980	broad.mit.edu	37	chr6	111694285	111694285	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gaacacagaaagaatccattAttgagttagaccgagttgtt	9	6	0	4			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr6:111694285A>G	ENST00000435970.1	-	15	5855	c.5039T>C	c.(5038-5040)aTa>aCa	p.I1680T	REV3L_ENST00000368802.3_Missense_Mutation_p.I1758T|REV3L_ENST00000358835.3_Missense_Mutation_p.I1758T|REV3L_ENST00000368805.1_Missense_Mutation_p.I1758T			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1758					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGAATCCATTATTGAGTTAGA	0.393								DNA polymerases (catalytic subunits)					5	195					0	0	1	0	0	G	111694285	A	G	111694285	3	3	33	1	0	0	0	0	1	0	0	0	13291	449	16	4	4199	4	REV3L	6	111694285	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	1612829	111694285	59420782	24	3111										
TULP4	56995	broad.mit.edu	37	chr6	158923248	158923248	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cccaccacagcagcacccccGccccctctgccgcccccaca	5	27	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr6:158923248G>C	ENST00000367097.3	+	13	3910	c.2553G>C	c.(2551-2553)ccG>ccC	p.P851P	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	851					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CAGCACCCCCGCCCCCTCTGC	0.657													5	17					0	0	1	0	0	C	158923248	G	C	158923248	2	2	33	1	0	0	0	0	0	0	0	1	16837	1074	38	5		5	TULP4	6	158923248	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	47228963	158923248	12191819	25	3112										
C7orf50	84310	broad.mit.edu	37	chr7	1167007	1167007	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gtcacttcaggaacttttctCttctgttttgccatcctgca	6	12	4	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:1167007C>A	ENST00000397098.3	-	2	941	c.15G>T	c.(13-15)aaG>aaT	p.K5N	C7orf50_ENST00000397100.2_Missense_Mutation_p.K5N|C7orf50_ENST00000357429.6_Missense_Mutation_p.K5N|C7orf50_ENST00000488073.1_5'UTR			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	5							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GAACTTTTCTCTTCTGTTTTG	0.443													4	3					0.150653	0.152048	1	1	0	A	1167007	C	A	1167007	3	1	33	1	0	0	0	0	1	0	0	0	2415	912	32	2	585	2	C7orf50	7	1167007	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08		1167007	157971656	26	3113										
NPY	4852	broad.mit.edu	37	chr7	24324969	24324969	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ctccaagccggacaacccggGcgaggacgcaccagcggagg	15	15	0	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:24324969G>A	ENST00000407573.1	+	3	400	c.110G>A	c.(109-111)gGc>gAc	p.G37D	NPY_ENST00000405982.1_Missense_Mutation_p.G37D|NPY_ENST00000242152.2_Missense_Mutation_p.G37D			P01303	NPY_HUMAN	neuropeptide Y	37					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity			breast(1)|kidney(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	9						GACAACCCGGGCGAGGACGCA	0.672													16	28					0	0	1	0	0	A	24324969	G	A	24324969	3	1	33	1	0	0	0	0	1	0	0	0	10654	1203	42	3	112	3	NPY	7	24324969	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	23157962	24324969	134813694	27	3114										
URGCP	55665	broad.mit.edu	37	chr7	43918018	43918018	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gagatttctgtcaagagcttAaactgcagccagtgagaccc	10	10	2	3			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:43918018A>C	ENST00000336086.6	-	4	3151	c.915T>G	c.(913-915)ttT>ttG	p.F305L	URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000443736.1_Missense_Mutation_p.F305L|URGCP_ENST00000402306.3_Missense_Mutation_p.F339L|URGCP_ENST00000447717.3_Missense_Mutation_p.F305L|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000453200.1_Missense_Mutation_p.F348L|URGCP_ENST00000223341.7_Missense_Mutation_p.F305L			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	348					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCAAGAGCTTAAACTGCAGCC	0.463													48	65					0	0	1	0	0	C	43918018	A	C	43918018	3	2	33	1	0	0	0	0	1	0	0	0	17085	359	13	4	1755	4	URGCP	7	43918018	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	19593049	43918018	115220645	28	3115										
PPP1R3A	5506	broad.mit.edu	37	chr7	113518383	113518383	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	attagttgacactgaaatttCagtatgatgtttggaaaaag	9	3	1	3			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:113518383C>T	ENST00000284601.3	-	4	2832	c.2764G>A	c.(2764-2766)Gaa>Aaa	p.E922K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	922					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ACTGAAATTTCAGTATGATGT	0.378													41	71					0	0	1	0	0	T	113518383	C	T	113518383	3	4	33	1	0	0	0	0	1	0	0	0	12419	835	29	3	608	3	PPP1R3A	7	113518383	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	69600365	113518383	45620280	29	3116										
PTPRZ1	5803	broad.mit.edu	37	chr7	121652768	121652768	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	aattagttctacaatgttgcAtctcattgtatcaaattctg	5	7	4	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:121652768A>G	ENST00000393386.2	+	12	4079	c.3668A>G	c.(3667-3669)cAt>cGt	p.H1223R	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1223					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACAATGTTGCATCTCATTGTA	0.398													5	140					0	0	1	0	0	G	121652768	A	G	121652768	3	3	33	1	0	0	0	0	1	0	0	0	12865	217	8	4	3714	4	PTPRZ1	7	121652768	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	8134385	121652768	37485895	30	3117										
MGAM	8972	broad.mit.edu	37	chr7	141736743	141736743	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tcttcttccgtgctcacagcCgaggggacacggtggccagg	14	13	3	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:141736743C>T	ENST00000475668.2	+	18	2251	c.2197C>T	c.(2197-2199)Cga>Tga	p.R733*	MGAM_ENST00000549489.2_Nonsense_Mutation_p.R733*			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	733	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGCTCACAGCCGAGGGGACAC	0.468													53	193					0	0	1	0	0	T	141736743	C	T	141736743	4	4	33	1	0	0	0	0	0	1	0	0	9590	644	23	1	2263	1	MGAM	7	141736743	Nonsense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	20083975	141736743	17401920	31	3118										
ZNF282	8427	broad.mit.edu	37	chr7	148895722	148895722	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	agagcaagtgggccgtgctgGggaccctgctgcaggagtac	17	10	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:148895722G>T	ENST00000262085.3	+	2	568	c.463G>T	c.(463-465)Ggg>Tgg	p.G155W	ZNF282_ENST00000479907.1_Missense_Mutation_p.G155W	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	155					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GGCCGTGCTGGGGACCCTGCT	0.647													5	185					0.014758	0.0154675	1	1	0	T	148895722	G	T	148895722	3	4	33	1	0	0	0	0	1	0	0	0	17876	1232	43	5	469	5	ZNF282	7	148895722	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	7158979	148895722	10242941	32	3119										
DOCK5	80005	broad.mit.edu	37	chr8	25258522	25258522	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	aagccgctgcatgagcggttGtcttcttgcttccgggaact	12	11	2	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:25258522G>T	ENST00000276440.7	+	47	4910	c.4866G>T	c.(4864-4866)ttG>ttT	p.L1622F		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1622	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ATGAGCGGTTGTCTTCTTGCT	0.483													6	140					0.00116845	0.00124863	1	1	0	T	25258522	G	T	25258522	3	4	33	1	0	0	0	0	1	0	0	0	4717	1368	48	5	5052	5	DOCK5	8	25258522	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		25258522	121105500	33	3120										
WHSC1L1	54904	broad.mit.edu	37	chr8	38178629	38178629	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ttctttggcacaacctcagtGgatttctctgattcagaacg	8	10	4	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:38178629G>T	ENST00000317025.8	-	8	2287	c.1770C>A	c.(1768-1770)tcC>tcA	p.S590S	WHSC1L1_ENST00000527502.1_Silent_p.S590S|WHSC1L1_ENST00000316985.3_Silent_p.S590S|WHSC1L1_ENST00000433384.2_Silent_p.S590S	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	590					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CAACCTCAGTGGATTTCTCTG	0.358			T	NUP98	AML								22	37					1.10513e-12	1.24185e-12	1	1	0	T	38178629	G	T	38178629	2	4	33	1	0	0	0	0	0	0	0	1	17422	1335	47	5		5	WHSC1L1	8	38178629	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	12920107	38178629	108185393	34	3121										
PKHD1L1	93035	broad.mit.edu	37	chr8	110467013	110467013	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	taccttgcatggtcacctgcGatctcctgagctccctgtct	8	15	3	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:110467013G>C	ENST00000378402.5	+	45	6910	c.6806G>C	c.(6805-6807)cGa>cCa	p.R2269P		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2269	G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGTCACCTGCGATCTCCTGAG	0.493										HNSCC(38;0.096)			34	42					0	0	1	0	0	C	110467013	G	C	110467013	3	2	33	1	0	0	0	0	1	0	0	0	12019	1058	37	2	6984	2	PKHD1L1	8	110467013	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	72288384	110467013	35897009	35	3122										
DMRT3	58524	broad.mit.edu	37	chr9	990202	990202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ccgtggaggaagggggatacGctgtccagaaaaacggaggc	17	8	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:990202G>A	ENST00000190165.2	+	2	654	c.616G>A	c.(616-618)Gct>Act	p.A206T		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	206					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity	p.A206T(1)|p.A69T(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		AGGGGGATACGCTGTCCAGAA	0.597													12	109					0	0	1	0	0	A	990202	G	A	990202	3	1	33	1	0	0	0	0	1	0	0	0	4615	1087	38	1	622	1	DMRT3	9	990202	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		990202	140223229	36	3123										
TRPM6	140803	broad.mit.edu	37	chr9	77377523	77377523	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	agacagtttctgctgaaaaaGgaactcgctttagattagag	10	6	1	4			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:77377523G>C	ENST00000451710.3	-	26	4301	c.4064C>G	c.(4063-4065)cCt>cGt	p.P1355R	TRPM6_ENST00000449912.2_Missense_Mutation_p.P1350R|TRPM6_ENST00000360774.1_Missense_Mutation_p.P1355R|TRPM6_ENST00000376864.4_Missense_Mutation_p.P1355R|TRPM6_ENST00000361255.3_Missense_Mutation_p.P1350R|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1355					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGCTGAAAAAGGAACTCGCTT	0.478													6	144					0	0	1	0	0	C	77377523	G	C	77377523	3	2	33	1	0	0	0	0	1	0	0	0	16650	1000	35	5	2060	5	TRPM6	9	77377523	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	76387321	77377523	63835908	37	3124										
DFNB31	25861	broad.mit.edu	37	chr9	117240804	117240804	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggagaatacggtgtctgagaGgctggcctcctttccccacc	12	13	1	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:117240804G>T	ENST00000374057.3	-	2	1514	c.866C>A	c.(865-867)cCt>cAt	p.P289H	DFNB31_ENST00000362057.3_Intron|DFNB31_ENST00000265134.6_Intron			Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	289	PDZ 2.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GTGTCTGAGAGGCTGGCCTCC	0.612													16	2					4.14922e-12	4.61495e-12	1	1	0	T	117240804	G	T	117240804	3	4	33	1	0	0	0	0	1	0	0	0	4483	1015	35	5		5	DFNB31	9	117240804	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	39863281	117240804	23972627	38	3125										
TPRN	286262	broad.mit.edu	37	chr9	140086700	140086700	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ccccccagcgctccactcccCcgcatctcaccatggcctcc	5	25	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:140086700C>T	ENST00000321773.2	-	3	1900	c.1901G>A	c.(1900-1902)gGg>gAg	p.G634E	TPRN_ENST00000409012.4_Intron			Q4KMQ1	TPRN_HUMAN	taperin	691					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						CTCCACTCCCCCGCATCTCAC	0.662													53	57					0	0	1	0	0	T	140086700	C	T	140086700	3	4	33	1	0	0	0	0	1	0	0	0	16481	623	22	3	139	3	TPRN	9	140086700	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	22845896	140086700	1126731	39	3126										
INPP5F	22876	broad.mit.edu	37	chr10	121586918	121586918	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	aatcaacagaacagacacctTctcggccatcgcaattagat	6	12	2	3	rs140846782		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr10:121586918T>A	ENST00000361976.2	+	20	3191	c.3025T>A	c.(3025-3027)Tct>Act	p.S1009T	INPP5F_ENST00000369080.3_Missense_Mutation_p.S399T	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	1009							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		ACAGACACCTTCTCGGCCATC	0.453													32	68					0	0	1	0	0	A	121586918	T	A	121586918	3	1	33	1	0	0	0	0	1	0	0	0	7801	1783	62	4	3103	4	INPP5F	10	121586918	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08		121586918	13947829	40	3127										
OR51T1	401665	broad.mit.edu	37	chr11	4903359	4903359	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tgttgatctatgtctgaccaTtacgacccttcccactgtgc	7	13	2	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr11:4903359T>C	ENST00000380378.1	+	1	311	c.311T>C	c.(310-312)aTt>aCt	p.I104T	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR51T1_ENST00000322049.1_Missense_Mutation_p.I77T	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTCTGACCATTACGACCCTT	0.443													20	20					0	0	1	0	0	C	4903359	T	C	4903359	3	2	33	1	0	0	0	0	1	0	0	0	11153	1493	52	4	313	4	OR51T1	11	4903359	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08		4903359	130103157	41	3128										
KIRREL3	84623	broad.mit.edu	37	chr11	126305176	126305176	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tccgtacctgcttccagcccGgctcccgacttcatttccga	7	18	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr11:126305176G>A	ENST00000525144.2	-	13	1824	c.1575C>T	c.(1573-1575)gcC>gcT	p.A525A	KIRREL3_ENST00000416561.2_Intron|KIRREL3_ENST00000529097.2_Intron|KIRREL3_ENST00000525704.2_Silent_p.A525A	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	525					hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CTTCCAGCCCGGCTCCCGACT	0.607													32	5					0	0	1	0	0	A	126305176	G	A	126305176	2	1	33	1	0	0	0	0	0	0	0	1	8368	1103	39	1		1	KIRREL3	11	126305176	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	121401817	126305176	8701340	42	3129										
TIMELESS	8914	broad.mit.edu	37	chr12	56817131	56817131	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ctgacagctgaaaaagtaggGcttccattttgaggtcatgg	12	7	1	3			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:56817131G>C	ENST00000229201.4	-	18	2370	c.2216C>G	c.(2215-2217)gCc>gGc	p.A739G	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.A740G	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	740					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						AAAAAGTAGGGCTTCCATTTT	0.502													28	82					0	0	1	0	0	C	56817131	G	C	56817131	3	2	33	1	0	0	0	0	1	0	0	0	15963	1203	42	5	1455	5	TIMELESS	12	56817131	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		56817131	77034764	43	3130										
ANO4	121601	broad.mit.edu	37	chr12	101295429	101295429	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	catttctcattccaggtttaAgtttatctattcatggggct	7	8	3	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:101295429A>C	ENST00000538618.1	+	4	364	c.364A>C	c.(364-366)Agt>Cgt	p.S122R	ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000551148.1_3'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCCAGGTTTAAGTTTATCTAT	0.488										HNSCC(74;0.22)			6	47					0	0	1	0	0	C	101295429	A	C	101295429	3	2	33	1	0	0	0	0	1	0	0	0	693	87	3	4		4	ANO4	12	101295429	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	44478298	101295429	32556466	44	3131										
SLC5A8	160728	broad.mit.edu	37	chr12	101561910	101561910	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggaaccaaaatgcccaaagcGaacaggcccataagtggtcc	10	12	0	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:101561910G>A	ENST00000536262.2	-	11	1842	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	428					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGCCCAAAGCGAACAGGCCCA	0.398													4	16					0	0	1	0	0	A	101561910	G	A	101561910	2	1	33	1	0	0	0	0	0	0	0	1	14725	1049	37	1		1	SLC5A8	12	101561910	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	266481	101561910	32289985	45	3132										
KNTC1	9735	broad.mit.edu	37	chr12	123075167	123075167	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cctgtaggtatttaattgtcGcttggtagatcttgacctgg	11	7	1	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:123075167G>A	ENST00000333479.7	+	41	4190	c.4013G>A	c.(4012-4014)cGc>cAc	p.R1338H	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1338					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTTAATTGTCGCTTGGTAGAT	0.368													5	124					0	0	1	0	0	A	123075167	G	A	123075167	3	1	33	1	0	0	0	0	1	0	0	0	8470	1087	38	1	4171	1	KNTC1	12	123075167	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	21513257	123075167	10776728	46	3133										
ABCB9	23457	broad.mit.edu	37	chr12	123435080	123435080	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gatgacgatgccatcaatggCgcggcccgtgtagtagggca	15	10	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:123435080C>A	ENST00000542678.1	-	3	3472	c.634G>T	c.(634-636)Gcc>Tcc	p.A212S	ABCB9_ENST00000346530.5_Missense_Mutation_p.A212S|ABCB9_ENST00000442028.2_Missense_Mutation_p.A212S|ABCB9_ENST00000344275.7_Missense_Mutation_p.A212S|ABCB9_ENST00000540285.1_Missense_Mutation_p.A212S|ABCB9_ENST00000280560.8_Missense_Mutation_p.A212S|ABCB9_ENST00000392439.3_Missense_Mutation_p.A212S|ABCB9_ENST00000442833.2_Missense_Mutation_p.A212S			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	212	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding	p.A212T(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CCATCAATGGCGCGGCCCGTG	0.632													3	45					0.115264	0.117418	1	1	0	A	123435080	C	A	123435080	3	1	33	1	0	0	0	0	1	0	0	0	48	768	27	5	1706	5	ABCB9	12	123435080	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	359913	123435080	10416815	47	3134										
PITPNM2	57605	broad.mit.edu	37	chr12	123494604	123494604	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ctcgttgtggggcacagggtCtttgacaatgtcgatgaagt	14	7	1	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:123494604C>A	ENST00000280562.5	-	5	641	c.436G>T	c.(436-438)Gac>Tac	p.D146Y	PITPNM2_ENST00000546049.1_Missense_Mutation_p.D146Y|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000320201.4_Missense_Mutation_p.D146Y|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Missense_Mutation_p.D146Y			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	146					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GGCACAGGGTCTTTGACAATG	0.567													62	54					7.92265e-33	9.48976e-33	1	1	0	A	123494604	C	A	123494604	3	1	33	1	0	0	0	0	1	0	0	0	11998	913	32	2	3697	2	PITPNM2	12	123494604	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	59524	123494604	10357291	48	3135										
MTUS2	23281	broad.mit.edu	37	chr13	29600313	29600313	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cctggaccctcaaagtggccGctcagaagcacgggaaagca	12	13	2	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr13:29600313G>A	ENST00000431530.3	+	1	1566	c.1508G>A	c.(1507-1509)cGc>cAc	p.R503H		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	493						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CAAAGTGGCCGCTCAGAAGCA	0.498													21	11					0	0	1	0	0	A	29600313	G	A	29600313	3	1	33	1	0	0	0	0	1	0	0	0	10013	1087	38	1	1510	1	MTUS2	13	29600313	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		29600313	85569565	49	3136										
DAAM1	23002	broad.mit.edu	37	chr14	59826213	59826213	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gcgagatattcctcaagctgCgaaagtaaagtaagtactta	9	7	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr14:59826213C>A	ENST00000395125.1	+	21	2677	c.2654C>A	c.(2653-2655)gCg>gAg	p.A885E	DAAM1_ENST00000553966.1_3'UTR|DAAM1_ENST00000360909.3_Missense_Mutation_p.A875E|DAAM1_ENST00000351081.1_Missense_Mutation_p.A885E	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	885	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CCTCAAGCTGCGAAAGTAAAG	0.378													6	13					3.59834e-05	3.92219e-05	1	1	0	A	59826213	C	A	59826213	3	1	33	1	0	0	0	0	1	0	0	0	4239	768	27	5	2736	5	DAAM1	14	59826213	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08		59826213	47523327	50	3137										
IQGAP1	8826	broad.mit.edu	37	chr15	90931626	90931626	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cgtggcccggccgcactatgGctgtgagtgcggggctccgc	17	14	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr15:90931626G>A	ENST00000268182.5	+	1	177	c.53G>A	c.(52-54)gGc>gAc	p.G18D	IQGAP1_ENST00000560738.1_Missense_Mutation_p.G18D	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	18					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CCGCACTATGGCTGTGAGTGC	0.716													4	9					0	0	1	0	0	A	90931626	G	A	90931626	3	1	33	1	0	0	0	0	1	0	0	0	7857	1203	42	3	55	3	IQGAP1	15	90931626	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		90931626	11599766	51	3138										
SSTR5	0	broad.mit.edu	37	chr16	1129080	1129080	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggtgctgcgcttcgccaagaTgaagaccgtcaccaacatct	10	13	2	3			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:1129080T>C	ENST00000293897.4	+	1	300	c.212T>C	c.(211-213)aTg>aCg	p.M71T	SSTR5_ENST00000562758.1_Missense_Mutation_p.M71T|SSTR5_ENST00000397547.2_Missense_Mutation_p.M71T	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	71					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	TTCGCCAAGATGAAGACCGTC	0.647													15	22					0	0	1	0	0	C	1129080	T	C	1129080	3	2	33	1	0	0	0	0	1	0	0	0	15256	1464	51	4	214	4	SSTR5	16	1129080	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08		1129080	89225673	52	3139										
RNF151	146310	broad.mit.edu	37	chr16	2018541	2018541	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggcctgccccaacgagggctGcacctcgcaggtgccgcgtg	15	16	0	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:2018541G>T	ENST00000569714.1	+	4	361	c.353G>T	c.(352-354)tGc>tTc	p.C118F	RNF151_ENST00000321392.3_Missense_Mutation_p.C117F|RNF151_ENST00000569210.2_3'UTR	NM_174903.4	NP_777563.2	Q2KHN1	RN151_HUMAN	ring finger protein 151	118					cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(1)	2						AACGAGGGCTGCACCTCGCAG	0.697													3	19					0.004672	0.00494416	1	1	0	T	2018541	G	T	2018541	3	4	33	1	0	0	0	0	1	0	0	0	13503	1319	46	5	367	5	RNF151	16	2018541	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	889461	2018541	88336212	53	3140										
FLYWCH1	84256	broad.mit.edu	37	chr16	2983818	2983818	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ctggggagaaggtgtattggAcctgccgggaccaggcccgc	17	11	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:2983818A>C	ENST00000399667.2	+	6	1714	c.1351A>C	c.(1351-1353)Acc>Ccc	p.T451P	FLYWCH1_ENST00000253928.9_Missense_Mutation_p.T451P|FLYWCH1_ENST00000416288.2_Missense_Mutation_p.T450P			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	451						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						GGTGTATTGGACCTGCCGGGA	0.692													4	12					0	0	1	0	0	C	2983818	A	C	2983818	3	2	33	1	0	0	0	0	1	0	0	0	5979	275	10	4	1362	4	FLYWCH1	16	2983818	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	965277	2983818	87370935	54	3141										
ZNF174	7727	broad.mit.edu	37	chr16	3452156	3452156	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ctgccgccagagcttcagacGcttttgttatcaagaggtgt	11	10	2	3			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:3452156G>A	ENST00000268655.4	+	1	737	c.152G>A	c.(151-153)cGc>cAc	p.R51H	ZNF174_ENST00000575752.1_Missense_Mutation_p.R51H|ZNF174_ENST00000571936.1_Missense_Mutation_p.R51H|ZNF174_ENST00000344823.5_Missense_Mutation_p.R51H|ZNF174_ENST00000572544.1_Missense_Mutation_p.R51H|LA16c-306E5.2_ENST00000575785.1_RNA	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	51					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						AGCTTCAGACGCTTTTGTTAT	0.547													8	388					0	0	1	0	0	A	3452156	G	A	3452156	3	1	33	1	0	0	0	0	1	0	0	0	17801	1087	38	1	154	1	ZNF174	16	3452156	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	468338	3452156	86902597	55	3142										
C16orf90	646174	broad.mit.edu	37	chr16	3543946	3543946	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gagcctagaaggactaggctGggggagggcacccttgtctg	17	9	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:3543946G>A	ENST00000437192.3	-	3	444	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	LA16c-306E5.3_ENST00000574423.2_RNA	NM_001080524.1	NP_001073993.1	A8MZG2	CP090_HUMAN	chromosome 16 open reading frame 90	138										large_intestine(1)	1						GGACTAGGCTGGGGGAGGGCA	0.627													6	13					0	0	1	0	0	A	3543946	G	A	3543946	4	1	33	1	0	0	0	0	0	1	0	0	1850	1357	47	3	110	3	C16orf90	16	3543946	Nonsense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	91790	3543946	86810807	56	3143										
ZNF267	10308	broad.mit.edu	37	chr16	31927691	31927691	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tcatacctcactacacatcgGagaagtcatagtggagagag	10	9	3	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:31927691G>T	ENST00000300870.10	+	4	2330	c.2121G>T	c.(2119-2121)cgG>cgT	p.R707R	RP11-170L3.8_ENST00000575471.1_RNA	NM_001265588.1|NM_003414.5	NP_001252517.1|NP_003405.3	Q14586	ZN267_HUMAN	zinc finger protein 267	707					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(5)|kidney(1)|large_intestine(14)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	41						CTACACATCGGAGAAGTCATA	0.438													25	17					1.1804e-14	1.36876e-14	1	1	0	T	31927691	G	T	31927691	2	4	33	1	0	0	0	0	0	0	0	1	17863	1161	41	2		2	ZNF267	16	31927691	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	28383745	31927691	58427062	57	3144										
LRRC36	55282	broad.mit.edu	37	chr16	67400946	67400946	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gacactactcgcctcgtcagTccacagtccgatccccagag	8	17	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:67400946T>C	ENST00000329956.6	+	8	800	c.781T>C	c.(781-783)Tcc>Ccc	p.S261P	LRRC36_ENST00000541146.1_Intron|LRRC36_ENST00000435835.3_Missense_Mutation_p.S140P|LRRC36_ENST00000563189.1_Missense_Mutation_p.S140P|LRRC36_ENST00000290940.7_5'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	261										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GCCTCGTCAGTCCACAGTCCG	0.433													5	102					0	0	1	0	0	C	67400946	T	C	67400946	3	2	33	1	0	0	0	0	1	0	0	0	9034	1667	58	4	839	4	LRRC36	16	67400946	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08	35473255	67400946	22953807	58	3145										
SLC7A6	9057	broad.mit.edu	37	chr16	68308894	68308894	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ttgtgtgggccattggtgggCtcttctctgttgtgggtgcc	16	8	2	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:68308894C>T	ENST00000566454.1	+	4	534	c.265C>T	c.(265-267)Ctc>Ttc	p.L89F	SLC7A6_ENST00000219343.6_Missense_Mutation_p.L89F	NM_001076785.2	NP_001070253.1	Q92536	YLAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	89					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		CATTGGTGGGCTCTTCTCTGT	0.552													4	97					0	0	1	0	0	T	68308894	C	T	68308894	3	4	33	1	0	0	0	0	1	0	0	0	14755	797	28	3	267	3	SLC7A6	16	68308894	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	907948	68308894	22045859	59	3146										
ZFP90	146198	broad.mit.edu	37	chr16	68597568	68597568	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	atgtggaaaggccttcaggcAtagctcatctcttggtcagc	11	10	4	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:68597568A>G	ENST00000570495.1	+	5	1170	c.878A>G	c.(877-879)cAt>cGt	p.H293R	ZFP90_ENST00000563169.2_Missense_Mutation_p.H293R|RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.H293R			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	293					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GCCTTCAGGCATAGCTCATCT	0.488													54	30					0	0	1	0	0	G	68597568	A	G	68597568	3	3	33	1	0	0	0	0	1	0	0	0	17711	217	8	4	892	4	ZFP90	16	68597568	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	288674	68597568	21757185	60	3147										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	5					0	0	1	0	0	T	7577538	C	T	7577538	3	4	33	1	0	0	0	0	1	0	0	0	16441	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08		7577538	73617672	61	3148										
TBX2	6909	broad.mit.edu	37	chr17	59485535	59485535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cagctgccgccgccgcagccGccggctccctctcccggagc	12	22	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:59485535G>A	ENST00000240328.3	+	7	2088	c.1807G>A	c.(1807-1809)Gcc>Acc	p.A603T	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	603	Ala-rich.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						cgccgcagccgccgGCTCCCT	0.701													5	59					0	0	1	0	0	A	59485535	G	A	59485535	3	1	33	1	0	0	0	0	1	0	0	0	15714	1087	38	1	1833	1	TBX2	17	59485535	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	51907997	59485535	21709675	62	3149										
SDK2	54549	broad.mit.edu	37	chr17	71344825	71344825	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tatttggtgacatcctcatcCgagtagtgcaggctgcctgg	12	10	1	1	rs150319493	byFrequency	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:71344825C>G	ENST00000392650.3	-	44	6078	c.6078G>C	c.(6076-6078)tcG>tcC	p.S2026S	SDK2_ENST00000410094.1_5'UTR|SDK2_ENST00000388726.3_Silent_p.S2007S	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2026					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CATCCTCATCCGAGTAGTGCA	0.642													4	56					0	0	1	0	0	G	71344825	C	G	71344825	2	3	33	1	0	0	0	0	0	0	0	1	14022	639	23	5		5	SDK2	17	71344825	Silent	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	11859290	71344825	9850385	63	3150										
ZNF750	79755	broad.mit.edu	37	chr17	80788321	80788321	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tgctcctcgctgctgtccacCgcgcatgcgtctggagcctc	11	17	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:80788321C>T	ENST00000269394.3	-	3	2702	c.1869G>A	c.(1867-1869)gcG>gcA	p.A623A	TBCD_ENST00000539345.2_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|ZNF750_ENST00000572562.1_Silent_p.A224A	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	623						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGCTGTCCACCGCGCATGCGT	0.711													17	58					0	0	1	0	0	T	80788321	C	T	80788321	2	4	33	1	0	0	0	0	0	0	0	1	18181	639	23	1		1	ZNF750	17	80788321	Silent	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	9443496	80788321	406889	64	3151										
ABCA7	10347	broad.mit.edu	37	chr19	1044627	1044627	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ggcagcccagacctggaggcCgggaccacatggaggccctg	16	14	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:1044627C>T	ENST00000263094.6	+	11	1330	c.1099C>T	c.(1099-1101)Cgg>Tgg	p.R367W	ABCA7_ENST00000435683.2_Missense_Mutation_p.R229W|ABCA7_ENST00000433129.1_Missense_Mutation_p.R367W	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	367					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGGAGGCCGGGACCACAT	0.657													21	21					0	0	1	0	0	T	1044627	C	T	1044627	3	4	33	1	0	0	0	0	1	0	0	0	37	643	23	1	1137	1	ABCA7	19	1044627	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08		1044627	58084356	65	3152										
MYO1F	4542	broad.mit.edu	37	chr19	8609289	8609289	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	agtgtctggtctgctcccccGcccgtggcgtgcatggtggc	15	14	2	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:8609289G>A	ENST00000338257.8	-	14	1683	c.1416C>T	c.(1414-1416)ggC>ggT	p.G472G		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	472	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CTGCTCCCCCGCCCGTGGCGT	0.667													13	19					0	0	1	0	0	A	8609289	G	A	8609289	2	1	33	1	0	0	0	0	0	0	0	1	10120	1074	38	1		1	MYO1F	19	8609289	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	7564662	8609289	50519694	66	3153										
ZNF676	163223	broad.mit.edu	37	chr19	22375867	22375867	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ttcatattccagggctctttTccttgctccagaaaaatgat	6	10	2	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:22375867T>C	ENST00000397121.2	-	2	398	c.81A>G	c.(79-81)ggA>ggG	p.G27G		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	27	KRAB.		G -> E (in dbSNP:rs8104929).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGGGCTCTTTTCCTTGCTCCA	0.403													4	104					0	0	1	0	0	C	22375867	T	C	22375867	2	2	33	1	0	0	0	0	0	0	0	1	18139	1770	62	4		4	ZNF676	19	22375867	Silent	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08	13766578	22375867	36753116	67	3154										
ATP4A	495	broad.mit.edu	37	chr19	36047934	36047934	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tggaaagttcatggcctctaCgtcgaaggcatagccaggcg	13	10	2	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:36047934C>G	ENST00000262623.3	-	12	1778	c.1750G>C	c.(1750-1752)Gta>Cta	p.V584L		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	584					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ATGGCCTCTACGTCGAAGGCA	0.592													41	149					0	0	1	0	0	G	36047934	C	G	36047934	3	3	33	1	0	0	0	0	1	0	0	0	1144	536	19	5	1401	5	ATP4A	19	36047934	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	13672067	36047934	23081049	68	3155										
PRODH2	58510	broad.mit.edu	37	chr19	36297437	36297437	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cacctcgtaccagcttcactCcgaaggccaggccggccctg	10	18	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:36297437C>A	ENST00000301175.3	-	8	1141	c.1124G>T	c.(1123-1125)gGa>gTa	p.G375V		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	375					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGCTTCACTCCGAAGGCCAG	0.622													81	223					7.81431e-29	9.25826e-29	1	1	0	A	36297437	C	A	36297437	3	1	33	1	0	0	0	0	1	0	0	0	12600	855	30	2	502	2	PRODH2	19	36297437	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	249503	36297437	22831546	69	3156										
FCGBP	8857	broad.mit.edu	37	chr19	40411752	40411752	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gccacgttctcctgcaggacGgcaaaccgatgcaggccagg	13	14	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:40411752G>A	ENST00000221347.6	-	7	3883	c.3876C>T	c.(3874-3876)gcC>gcT	p.A1292A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1292	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCTGCAGGACGGCAAACCGAT	0.632													75	137					0	0	1	0	0	A	40411752	G	A	40411752	2	1	33	1	0	0	0	0	0	0	0	1	5810	1103	39	1		1	FCGBP	19	40411752	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	4114315	40411752	18717231	70	3157										
IRF2BP1	26145	broad.mit.edu	37	chr19	46388153	46388153	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	agcatcgtggaacatctggcGagccactgccaggacgccgg	14	13	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:46388153G>A	ENST00000302165.3	-	1	1223	c.880C>T	c.(880-882)Cgc>Tgc	p.R294C		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		AACATCTGGCGAGCCACTGCC	0.592													5	167					0	0	1	0	0	A	46388153	G	A	46388153	3	1	33	1	0	0	0	0	1	0	0	0	7872	1058	37	1	878	1	IRF2BP1	19	46388153	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	5976401	46388153	12740830	71	3158										
TRPM4	54795	broad.mit.edu	37	chr19	49671542	49671542	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tggattgtcactgggggtctGcacacgggcatcggccggca	16	11	2	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:49671542G>T	ENST00000252826.5	+	5	600	c.474G>T	c.(472-474)ctG>ctT	p.L158L	TRPM4_ENST00000355712.5_Intron|TRPM4_ENST00000427978.2_Silent_p.L158L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	158					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CTGGGGGTCTGCACACGGGCA	0.607													11	233					0.0167234	0.0173605	1	1	0	T	49671542	G	T	49671542	2	4	33	1	0	0	0	0	0	0	0	1	16648	1306	46	5		5	TRPM4	19	49671542	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	3283389	49671542	9457441	72	3159										
TMX4	56255	broad.mit.edu	37	chr20	7963214	7963214	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	ttgaatcatctttttcctccTccgcatcctgcaactgttca	4	14	3	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:7963214T>C	ENST00000246024.2	-	8	949	c.734A>G	c.(733-735)gAg>gGg	p.E245G		NM_021156.2	NP_066979.2	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	245	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane				endometrium(3)|large_intestine(2)|lung(11)|skin(1)	17						tttttcctcctcCGCATCCTG	0.423													9	25					0	0	1	0	0	C	7963214	T	C	7963214	3	2	33	1	0	0	0	0	1	0	0	0	16328	1551	54	4	319	4	TMX4	20	7963214	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08		7963214	55062306	73	3160										
SYCP2	10388	broad.mit.edu	37	chr20	58489063	58489063	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	caagcatgccatttacaaggTtgagaaatatcctgcaatcc	7	10	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:58489063T>C	ENST00000357552.3	-	12	1022	c.797A>G	c.(796-798)aAc>aGc	p.N266S	SYCP2_ENST00000371001.2_Missense_Mutation_p.N266S			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	266					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ATTTACAAGGTTGAGAAATAT	0.299													4	17					0	0	1	0	0	C	58489063	T	C	58489063	3	2	33	1	0	0	0	0	1	0	0	0	15488	1725	60	4	3931	4	SYCP2	20	58489063	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08	50525849	58489063	4536457	74	3161										
SLC17A9	63910	broad.mit.edu	37	chr20	61588851	61588851	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cctggggctccatcacggccGtcaccccactgctcgcccac	9	21	2	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:61588851G>A	ENST00000370349.3	+	4	502	c.298G>A	c.(298-300)Gtc>Atc	p.V100I	SLC17A9_ENST00000488738.1_3'UTR|SLC17A9_ENST00000370351.4_Missense_Mutation_p.V106I			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	106					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						CATCACGGCCGTCACCCCACT	0.632													6	81					0	0	1	0	0	A	61588851	G	A	61588851	3	1	33	1	0	0	0	0	1	0	0	0	14478	1145	40	1	326	1	SLC17A9	20	61588851	Missense_Mutation	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	3099788	61588851	1436669	75	3162										
BAGE2	85319	broad.mit.edu	37	chr21	11066244	11066249	+	RNA	DEL	CAAAAA	CAAAAA	-													0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	aacagagtgagactccatctCaaaaacaaaaacaaaaacaa					rs4039879		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr21:11066244_11066249delCAAAAA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gactccatctcaaaaacaaaaacaaa	0.403													4	3	---	---	---	---						-	11066249	CAAAAA	-	11066244	6	5	33	0	1	1	0	1	0	0	0	0	1290	841	29	0		0	BAGE2	21	11066244	RNA	DEL	CAAAAA	TCGA-N9-A4PZ-01A-22D-A28R-08		11066244	37063651	76	3163										
ZNF280B	140883	broad.mit.edu	37	chr22	22842866	22842866	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tgctgtccatagtaaaagtcActaagtaacacaatgggatt	8	7	1	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr22:22842866A>G	ENST00000360412.2	-	4	1633	c.858T>C	c.(856-858)agT>agC	p.S286S	ZNF280B_ENST00000406426.1_Silent_p.S286S	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGTAAAAGTCACTAAGTAACA	0.383													4	81					0	0	1	0	0	G	22842866	A	G	22842866	2	3	33	1	0	0	0	0	0	0	0	1	17872	156	6	4		4	ZNF280B	22	22842866	Silent	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08		22842866	28461700	77	3164										
KLHL34	257240	broad.mit.edu	37	chrX	21674488	21674488	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cccgagatgtacacaacaccGcggtccccgacggcccccgc	10	20	0	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:21674488G>A	ENST00000379499.2	-	1	1960	c.1419C>T	c.(1417-1419)cgC>cgT	p.R473R		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	473										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						ACACAACACCGCGGTCCCCGA	0.701													13	7					0	0	1	0	0	A	21674488	G	A	21674488	2	1	33	1	0	0	0	0	0	0	0	1	8429	1074	38	1		1	KLHL34	23	21674488	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08		21674488	133596072	78	3165										
MAGEB2	4113	broad.mit.edu	37	chrX	30236701	30236701	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tggtttacccagccatcatgCctcgtggtcagaagagtaag	11	10	2	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:30236701C>T	ENST00000378988.4	+	2	105	c.4C>T	c.(4-6)Cct>Tct	p.P2S		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	2							protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						AGCCATCATGCCTCGTGGTCA	0.527													6	38					0	0	1	0	0	T	30236701	C	T	30236701	3	4	33	1	0	0	0	0	1	0	0	0	9225	739	26	3	6	3	MAGEB2	23	30236701	Missense_Mutation	SNP	C	TCGA-N9-A4PZ-01A-22D-A28R-08	8562213	30236701	125033859	79	3166										
UBA1	7317	broad.mit.edu	37	chrX	47074220	47074220	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	gagattgtgagccgtgtgtcGaagcgaaagctgggccgcca	16	9	0	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:47074220G>A	ENST00000335972.6	+	26	3252	c.3069G>A	c.(3067-3069)tcG>tcA	p.S1023S	UBA1_ENST00000377351.4_Silent_p.S1023S|UBA1_ENST00000377269.3_Silent_p.S471S	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	1023					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCCGTGTGTCGAAGCGAAAGC	0.602													7	215					0	0	1	0	0	A	47074220	G	A	47074220	2	1	33	1	0	0	0	0	0	0	0	1	16887	1045	37	1		1	UBA1	23	47074220	Silent	SNP	G	TCGA-N9-A4PZ-01A-22D-A28R-08	16837519	47074220	108196340	80	3167										
MED12	9968	broad.mit.edu	37	chrX	70360623	70360623	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	cagcaacagcagcaacagcaAcagcagcagcagcagcaaca	9	14	0	0			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:70360623A>G	ENST00000333646.6	+	42	6391	c.6192A>G	c.(6190-6192)caA>caG	p.Q2064Q	MED12_ENST00000374080.3_Silent_p.Q2061Q|MED12_ENST00000374102.1_Silent_p.Q2060Q|MED12_ENST00000478889.1_3'UTR	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	2061	Gln-rich.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					agcaacagcaacagcagcagc	0.602			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						4	110					0	0	1	0	0	G	70360623	A	G	70360623	2	3	33	1	0	0	0	0	0	0	0	1	9477	40	2	4		4	MED12	23	70360623	Silent	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	23286403	70360623	84909937	81	3168										
ZNF711	7552	broad.mit.edu	37	chrX	84526455	84526455	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tcgtccttctgagctcaaaaAgcatagtgatatccataagg	8	9	2	2			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:84526455A>T	ENST00000360700.4	+	10	2931	c.2045A>T	c.(2044-2046)aAg>aTg	p.K682M	ZNF711_ENST00000373165.3_Missense_Mutation_p.K636M|ZNF711_ENST00000276123.3_Missense_Mutation_p.K636M|ZNF711_ENST00000395402.1_Missense_Mutation_p.K644M|ZNF711_ENST00000542798.1_Missense_Mutation_p.K478M			Q9Y462	ZN711_HUMAN	zinc finger protein 711	636				RCK -> GCT (in Ref. 4; CAA39837).	positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GAGCTCAAAAAGCATAGTGAT	0.403													7	45					0	0	1	0	0	T	84526455	A	T	84526455	3	4	33	1	0	0	0	0	1	0	0	0	18171	72	3	4	1933	4	ZNF711	23	84526455	Missense_Mutation	SNP	A	TCGA-N9-A4PZ-01A-22D-A28R-08	14165832	84526455	70744105	82	3169										
F9	2158	broad.mit.edu	37	chrX	138642950	138642950	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0240963855421687	2	1	0.425595238095238	0.993055555555556	0.270833333333333	1	1	0	tgtggaggctctatcgttaaTgaaaaatggattgtaactgc	11	5	1	1			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:138642950T>G	ENST00000218099.2	+	7	781	c.774T>G	c.(772-774)aaT>aaG	p.N258K	F9_ENST00000394090.2_Missense_Mutation_p.N220K	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	258	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	CTATCGTTAATGAAAAATGGA	0.353													4	108					0	0	1	0	0	G	138642950	T	G	138642950	3	3	33	1	0	0	0	0	1	0	0	0	5382	1461	51	4	800	4	F9	23	138642950	Missense_Mutation	SNP	T	TCGA-N9-A4PZ-01A-22D-A28R-08	54116495	138642950	16627610	83	3170										
AMY2A	279	broad.mit.edu	37	chr1	104160643	104160643	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttggtgggaaagataccaacCagttagctataaattatgca	9	6	0	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:104160643C>A	ENST00000414303.2	+	2	300	c.236C>A	c.(235-237)cCa>cAa	p.P79Q		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	79					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	AGATACCAACCAGTTAGCTAT	0.353													23	230					2.21704e-12	2.45218e-12	1	1	0	A	104160643	C	A	104160643	3	1	34	1	0	0	0	0	1	0	0	0	590	594	21	5	242	5	AMY2A	1	104160643	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08		104160643	145089978	1	3171										
SEC22B	9554	broad.mit.edu	37	chr1	145101606	145101606	+	RNA	DEL	T	T	-													0	0	1	0	0	0	1	1	0	acagtaatgtttacagtgccTcttgtaaagtcaaaggattt					rs113062007		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:145101606delT	ENST00000453618.1	+	0	402							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TTACAGTGCCTCTTGTAAAGT	0.358													4	2	---	---	---	---						-	145101606	T	-	145101606	6	5	34	0	1	1	0	1	0	0	0	0	14042	1566	54	0		0	SEC22B	1	145101606	RNA	DEL	T	TCGA-N9-A4Q1-01A-11D-A28R-08	40940963	145101606	104149015	2	3172										
SEC22B	9554	broad.mit.edu	37	chr1	145109975	145109976	+	RNA	INS	-	-	C													0	0	1	0	0	0	1	1	0	cacatgtgacaggaactttgINSctaaagatctacttgattgg					rs67257307		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													3	5	---	---	---	---						C	145109976	-	C	145109975	6	5	34	0	1	1	1	0	0	0	0	0	14042	1334	46	0		0	SEC22B	1	145109975	RNA	INS	-	TCGA-N9-A4Q1-01A-11D-A28R-08	8369	145109975	104140646	3	3173										
PI4KB	5298	broad.mit.edu	37	chr1	151271532	151271532	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttgatccaaaggggcactcgCtcctgttcccaaatggactg	10	12	0	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:151271532C>A	ENST00000368875.2	-	10	2383	c.1803G>T	c.(1801-1803)gaG>gaT	p.E601D	PI4KB_ENST00000368872.1_Missense_Mutation_p.E574D|PI4KB_ENST00000368873.1_Missense_Mutation_p.E589D|PI4KB_ENST00000368874.4_Missense_Mutation_p.E574D|PI4KB_ENST00000529142.1_Missense_Mutation_p.E257D|PI4KB_ENST00000271657.5_Missense_Mutation_p.E601D	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	589	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGGCACTCGCTCCTGTTCCC	0.473													31	87					1.88708e-17	2.22189e-17	1	1	0	A	151271532	C	A	151271532	3	1	34	1	0	0	0	0	1	0	0	0	11921	796	28	5	699	5	PI4KB	1	151271532	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	6161557	151271532	97979089	4	3174										
TOR3A	64222	broad.mit.edu	37	chr1	179064258	179064258	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aagagacactggatgaaataGcccagatgatggtgtatgtc	12	6	0	4	rs78309022		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:179064258G>T	ENST00000367627.3	+	6	1851	c.1099G>T	c.(1099-1101)Gcc>Tcc	p.A367S	TOR3A_ENST00000352445.6_Intron	NM_022371.3	NP_071766.2	Q9H497	TOR3A_HUMAN	torsin family 3, member A	367					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|urinary_tract(1)	13						GGATGAAATAGCCCAGATGAT	0.512													5	231					1.23904e-05	1.29214e-05	1	1	0	T	179064258	G	T	179064258	3	4	34	1	0	0	0	0	1	0	0	0	16436	971	34	5	1121	5	TOR3A	1	179064258	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08	27792726	179064258	70186363	5	3175										
OR2M2	391194	broad.mit.edu	37	chr1	248344089	248344089	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ggcccacatctgatcactccCcaacgcaggacaagatggtg	10	14	2	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:248344089C>G	ENST00000359682.2	+	1	802	c.802C>G	c.(802-804)Cca>Gca	p.P268A		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGATCACTCCCCAACGCAGGA	0.502													101	138					0	0	1	0	0	G	248344089	C	G	248344089	3	3	34	1	0	0	0	0	1	0	0	0	11057	623	22	5	804	5	OR2M2	1	248344089	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	69279831	248344089	906532	6	3176										
OR2T4	127074	broad.mit.edu	37	chr1	248525481	248525481	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	catcaccatgaccttcccctTccgtggatcccgggagattc	8	16	1	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:248525481T>C	ENST00000366475.1	+	1	599	c.599T>C	c.(598-600)tTc>tCc	p.F200S		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTTCCCCTTCCGTGGATCC	0.493													65	183					0	0	1	0	0	C	248525481	T	C	248525481	3	2	34	1	0	0	0	0	1	0	0	0	11074	1783	62	4	601	4	OR2T4	1	248525481	Missense_Mutation	SNP	T	TCGA-N9-A4Q1-01A-11D-A28R-08	181392	248525481	725140	7	3177										
NEB	4703	broad.mit.edu	37	chr2	152432754	152432754	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	aaggttcaccacaggcgtccGatagacactgtcacaaaaga	9	11	2	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr2:152432754G>A	ENST00000397345.3	-	106	17021	c.16819C>T	c.(16819-16821)Cgg>Tgg	p.R5607W	NEB_ENST00000409198.1_Missense_Mutation_p.R3906W|NEB_ENST00000172853.10_Missense_Mutation_p.R3906W|NEB_ENST00000427231.2_Missense_Mutation_p.R5607W|NEB_ENST00000603639.1_Missense_Mutation_p.R5607W|NEB_ENST00000604864.1_Missense_Mutation_p.R5607W	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5618					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACAGGCGTCCGATAGACACTG	0.448													51	25					0	0	1	0	0	A	152432754	G	A	152432754	3	1	34	1	0	0	0	0	1	0	0	0	10348	1057	37	1	9175	1	NEB	2	152432754	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08		152432754	90766619	8	3178										
FAP	2191	broad.mit.edu	37	chr2	163099498	163099498	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctccaaatacgatttttaccCaagtctacataaaataaaga	3	9	1	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr2:163099498C>G	ENST00000188790.4	-	2	218	c.11G>C	c.(10-12)tGg>tCg	p.W4S	FAP_ENST00000443424.1_Missense_Mutation_p.W4S	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	4					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GATTTTTACCCAAGTCTACAT	0.388													4	11					0	0	1	0	0	G	163099498	C	G	163099498	3	3	34	1	0	0	0	0	1	0	0	0	5705	595	21	5	2371	5	FAP	2	163099498	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	10666744	163099498	80099875	9	3179										
NCKAP1	10787	broad.mit.edu	37	chr2	183866921	183866921	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0	0	1	0	0	0	1	1	0	ttgccttcctttcttcaattCgagacagcagtatcattagt	6	10	3	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr2:183866921C>G	ENST00000360982.2	-	6	1222	c.464G>C	c.(463-465)cGa>cCa	p.R155P	NCKAP1_ENST00000361354.3_Missense_Mutation_p.R149P	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	149					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding	p.R155Q(1)		breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTCTTCAATTCGAGACAGCAG	0.313													5	35					0	0	1	0	0	G	183866921	C	G	183866921	3	3	34	1	0	0	0	0	1	0	0	0	10267	884	31	2	3048	2	NCKAP1	2	183866921	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	20767423	183866921	59332452	10	3180										
OR5H2	79310	broad.mit.edu	37	chr3	98002239	98002239	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttcatgaagtccttatattcAgattaaccttctgcaattct	4	9	4	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:98002239A>C	ENST00000355273.2	+	1	508	c.508A>C	c.(508-510)Aga>Cga	p.R170R	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						CCTTATATTCAGATTAACCTT	0.328													25	60					0	0	1	0	0	C	98002239	A	C	98002239	2	2	34	1	0	0	0	0	0	0	0	1	11208	180	7	4		4	OR5H2	3	98002239	Silent	SNP	A	TCGA-N9-A4Q1-01A-11D-A28R-08		98002239	100020191	11	3181										
ALCAM	214	broad.mit.edu	37	chr3	105260569	105260570	+	Frame_Shift_Ins	INS	-	-	A													0	0	1	0	0	0	1	1	0	acaagtgttccctgatagacINSaaaaaaagcatgattgcttc							TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:105260569_105260570insA	ENST00000306107.5	+	8	1451_1452	c.951_952insA	c.(949-954)gaaaaafs	p.EK317fs	ALCAM_ENST00000472644.2_Frame_Shift_Ins_p.EK317fs|ALCAM_ENST00000486979.2_Frame_Shift_Ins_p.EK266fs|ALCAM_ENST00000389927.4_Intron|ALCAM_ENST00000481337.1_3'UTR	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	317	Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						CCCTGATAGACAAAAAAAGCAT	0.426													30	40	---	---	---	---						A	105260570	-	A	105260569	7	5	34	1	0	1	1	0	0	0	0	0	484	477	17	0	981	0	ALCAM	3	105260569	Frame_Shift_Ins	INS	-	TCGA-N9-A4Q1-01A-11D-A28R-08	7258330	105260569	92761861	12	3182										
STXBP5L	9515	broad.mit.edu	37	chr3	121100275	121100275	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgactctaccatctctccttGtctgttcgttggaaccagtc	7	13	3	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:121100275G>T	ENST00000273666.6	+	23	2826	c.2555G>T	c.(2554-2556)tGt>tTt	p.C852F	STXBP5L_ENST00000492541.1_Missense_Mutation_p.C852F|STXBP5L_ENST00000497029.1_Missense_Mutation_p.C826F|STXBP5L_ENST00000472879.1_Missense_Mutation_p.C828F|STXBP5L_ENST00000471454.1_Missense_Mutation_p.C828F	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	852					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ATCTCTCCTTGTCTGTTCGTT	0.408													55	83					2.30037e-20	2.7529e-20	1	1	0	T	121100275	G	T	121100275	3	4	34	1	0	0	0	0	1	0	0	0	15412	1377	48	5	2641	5	STXBP5L	3	121100275	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08	15839706	121100275	76922155	13	3183										
NCK1	4690	broad.mit.edu	37	chr3	136667191	136667191	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgtctactgcattgggcagCgtaaattcagcaccatggaa	10	10	2	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:136667191C>T	ENST00000469404.1	+	3	929	c.838C>T	c.(838-840)Cgt>Tgt	p.R280C	NCK1_ENST00000481752.1_Missense_Mutation_p.R344C|IL20RB_ENST00000484501.1_Intron|NCK1_ENST00000288986.2_Missense_Mutation_p.R344C	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	344					axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						CATTGGGCAGCGTAAATTCAG	0.348													19	32					0	0	1	0	0	T	136667191	C	T	136667191	3	4	34	1	0	0	0	0	1	0	0	0	10265	768	27	1	1040	1	NCK1	3	136667191	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	15566916	136667191	61355239	14	3184										
CP	1356	broad.mit.edu	37	chr3	148916171	148916171	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tacctgtctcccatttgcatGtaaacttcctttcttgcata	4	12	2	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:148916171G>T	ENST00000264613.6	-	9	1958	c.1696C>A	c.(1696-1698)Cat>Aat	p.H566N	CP_ENST00000462336.1_5'UTR	NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	566	F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CCATTTGCATGTAAACTTCCT	0.353													6	48					2.0095e-06	2.12599e-06	1	1	0	T	148916171	G	T	148916171	3	4	34	1	0	0	0	0	1	0	0	0	3810	1377	48	5	1545	5	CP	3	148916171	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08	12248980	148916171	49106259	15	3185										
SI	6476	broad.mit.edu	37	chr3	164741472	164741472	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tttagttggaggtcagctgtTatacccatggatgaatagcg	12	6	1	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:164741472T>C	ENST00000264382.3	-	26	3047	c.2985A>G	c.(2983-2985)atA>atG	p.I995M		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	995	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGTCAGCTGTTATACCCATGG	0.403										HNSCC(35;0.089)			7	61					0	0	1	0	0	C	164741472	T	C	164741472	3	2	34	1	0	0	0	0	1	0	0	0	14351	1744	61	4	2590	4	SI	3	164741472	Missense_Mutation	SNP	T	TCGA-N9-A4Q1-01A-11D-A28R-08	15825301	164741472	33280958	16	3186										
MCF2L2	23101	broad.mit.edu	37	chr3	183041097	183041097	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccgggtcagttggcttttgtCgatgtagccgtgaaggtcag	15	8	2	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:183041097C>A	ENST00000328913.3	-	6	826	c.529G>T	c.(529-531)Gac>Tac	p.D177Y	MCF2L2_ENST00000414362.2_Missense_Mutation_p.D177Y|MCF2L2_ENST00000473233.1_Missense_Mutation_p.D177Y|MCF2L2_ENST00000447025.2_Missense_Mutation_p.D177Y	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	177	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGGCTTTTGTCGATGTAGCCG	0.423													21	174					1.55795e-14	1.77703e-14	1	1	0	A	183041097	C	A	183041097	3	1	34	1	0	0	0	0	1	0	0	0	9429	884	31	2	2915	2	MCF2L2	3	183041097	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	18299625	183041097	14981333	17	3187										
RFC4	5984	broad.mit.edu	37	chr3	186510374	186510374	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cttgaagcggaattttgaacAtctagaggtcaggggttcaa	12	6	3	3			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:186510374A>G	ENST00000392481.2	-	7	861	c.580T>C	c.(580-582)Tgt>Cgt	p.C194R	RFC4_ENST00000296273.2_Missense_Mutation_p.C194R|RFC4_ENST00000433496.1_Missense_Mutation_p.C194R	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	194					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		AATTTTGAACATCTAGAGGTC	0.363													20	240					0	0	1	0	0	G	186510374	A	G	186510374	3	3	34	1	0	0	0	0	1	0	0	0	13298	217	8	4	531	4	RFC4	3	186510374	Missense_Mutation	SNP	A	TCGA-N9-A4Q1-01A-11D-A28R-08	3469277	186510374	11512056	18	3188										
MUC4	4585	broad.mit.edu	37	chr3	195511839	195511839	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acaggaagaggggtggcctgAcctgtggatgctgaggaagt	18	6	0	3			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:195511839A>T	ENST00000463781.3	-	2	7071	c.6612T>A	c.(6610-6612)ggT>ggA	p.G2204G	MUC4_ENST00000475231.1_Silent_p.G2204G|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	993					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGTGGCCTGACCTGTGGATG	0.597													3	18					0	0	1	0	0	T	195511839	A	T	195511839	2	4	34	1	0	0	0	0	0	0	0	1	10025	262	10	4		4	MUC4	3	195511839	Silent	SNP	A	TCGA-N9-A4Q1-01A-11D-A28R-08	9001465	195511839	2510591	19	3189										
ZNF518B	85460	broad.mit.edu	37	chr4	10446750	10446750	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	actgtcagtgactttgttttTtctgcagaaagtactttttc	7	7	2	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr4:10446750T>G	ENST00000326756.3	-	3	1641	c.1203A>C	c.(1201-1203)gaA>gaC	p.E401D		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ACTTTGTTTTTTCTGCAGAAA	0.378													8	151					0	0	1	0	0	G	10446750	T	G	10446750	3	3	34	1	0	0	0	0	1	0	0	0	18019	1838	64	4	2025	4	ZNF518B	4	10446750	Missense_Mutation	SNP	T	TCGA-N9-A4Q1-01A-11D-A28R-08		10446750	180707526	20	3190										
TMPRSS11F	389208	broad.mit.edu	37	chr4	68956262	68956262	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0	0	1	0	0	0	1	1	0	attctttcaatctgatgactCctttctataaactctcttga	3	10	5	3			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr4:68956262C>G	ENST00000356291.2	-	3	320	c.261G>C	c.(259-261)agG>agC	p.R87S		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	87	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						TCTGATGACTCCTTTCTATAA	0.294													4	18					0	0	1	0	0	G	68956262	C	G	68956262	3	3	34	1	0	0	0	0	1	0	0	0	16302	854	30	2	1087	2	TMPRSS11F	4	68956262	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	58509512	68956262	122198014	21	3191										
SCLT1	132320	broad.mit.edu	37	chr4	129867279	129867279	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cttccagttttctgtaatcaCtctcatttcctctgccttca	3	14	5	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr4:129867279C>T	ENST00000281142.5	-	16	1825	c.1322G>A	c.(1321-1323)aGt>aAt	p.S441N	SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	441			S -> C (in dbSNP:rs10028124).			centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TCTGTAATCACTCTCATTTCC	0.348													9	5					0	0	1	0	0	T	129867279	C	T	129867279	3	4	34	1	0	0	0	0	1	0	0	0	13959	565	20	3	768	3	SCLT1	4	129867279	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	60911017	129867279	61286997	22	3192										
FAM50B	26240	broad.mit.edu	37	chr6	3850736	3850736	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tcctggagctgcgctccgccGgcgtggagcagctcatgttc	14	14	1	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr6:3850736G>A	ENST00000380274.1	+	1	1117	c.691G>A	c.(691-693)Ggc>Agc	p.G231S	FAM50B_ENST00000380272.3_Missense_Mutation_p.G231S			Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	231						nucleus				cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(3)|urinary_tract(3)	17	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GCGCTCCGCCGGCGTGGAGCA	0.657													85	77					0	0	1	0	0	A	3850736	G	A	3850736	3	1	34	1	0	0	0	0	1	0	0	0	5613	1116	39	1	693	1	FAM50B	6	3850736	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08		3850736	167264331	23	3193										
CAP2	10486	broad.mit.edu	37	chr6	17556635	17556635	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tcaagacagcatgggatggaTccaagttaatcactgaacct	9	9	2	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr6:17556635T>G	ENST00000229922.2	+	13	1928	c.1396T>G	c.(1396-1398)Tcc>Gcc	p.S466A	CAP2_ENST00000378990.2_Missense_Mutation_p.S440A|CAP2_ENST00000465994.1_Missense_Mutation_p.S402A|CAP2_ENST00000493172.1_Missense_Mutation_p.S206A|CAP2_ENST00000489374.1_Missense_Mutation_p.S354A	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	466					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			ATGGGATGGATCCAAGTTAAT	0.403													32	39					0	0	1	0	0	G	17556635	T	G	17556635	3	3	34	1	0	0	0	0	1	0	0	0	2638	1435	50	4	1442	4	CAP2	6	17556635	Missense_Mutation	SNP	T	TCGA-N9-A4Q1-01A-11D-A28R-08	13705899	17556635	153558432	24	3194										
TRDN	10345	broad.mit.edu	37	chr6	123786032	123786033	+	In_Frame_Ins	INS	-	-	AAA													0	0	1	0	0	0	1	1	0	ctacaatagagatctttaagINSaaaaaaaaaagtacttgcct							TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr6:123786032_123786033insAAA	ENST00000546248.1	-	9	1022_1023	c.889_890insTTT	c.(889-891)tta>TTTtta	p.296_297insF	RP11-532N4.2_ENST00000587106.1_RNA|TRDN_ENST00000334268.4_Intron|RP11-532N4.2_ENST00000589182.1_RNA|RP11-532N4.2_ENST00000434768.1_RNA|RP11-532N4.2_ENST00000427828.1_RNA|RP11-532N4.2_ENST00000418467.2_RNA|TRDN_ENST00000398178.3_Intron	NM_001256020.1	NP_001242949.1	Q13061	TRDN_HUMAN	triadin	0					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		AGATCTTTAAGAAAAAAAAAAG	0.386													2	4	---	---	---	---						AAA	123786033	-	AAA	123786032	7	5	34	1	0	1	1	0	0	0	0	0	16528	957	33	0		0	TRDN	6	123786032	In_Frame_Ins	INS	-	TCGA-N9-A4Q1-01A-11D-A28R-08	106229397	123786032	47329035	25	3195										
SDK1	221935	broad.mit.edu	37	chr7	4119118	4119118	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttcctggtgccccatccaacCtggtcatttccaacatcagc	6	16	2	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:4119118C>A	ENST00000404826.2	+	22	3365	c.3226C>A	c.(3226-3228)Ctg>Atg	p.L1076M	SDK1_ENST00000389531.3_Missense_Mutation_p.L1076M	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1076	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCATCCAACCTGGTCATTTC	0.547													90	20					1.11079e-38	1.35147e-38	1	1	0	A	4119118	C	A	4119118	3	1	34	1	0	0	0	0	1	0	0	0	14021	680	24	5	3312	5	SDK1	7	4119118	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08		4119118	155019545	26	3196										
AMPH	273	broad.mit.edu	37	chr7	38457436	38457436	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0	0	1	0	0	0	1	1	0	ggtgctcaccactgcctcctCcactggctcctcagcccgag	9	19	2	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:38457436C>G	ENST00000356264.2	-	17	1602	c.1387G>C	c.(1387-1389)Gag>Cag	p.E463Q	AMPH_ENST00000428293.2_Intron|AMPH_ENST00000471913.1_Intron|AMPH_ENST00000325590.5_Intron	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	463					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						ACTGCCTCCTCCACTGGCTCC	0.602													26	30					0	0	1	0	0	G	38457436	C	G	38457436	3	3	34	1	0	0	0	0	1	0	0	0	584	864	30	2	720	2	AMPH	7	38457436	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	34338318	38457436	120681227	27	3197										
ADCK2	90956	broad.mit.edu	37	chr7	140373825	140373825	+	Frame_Shift_Del	DEL	T	T	-													0	0	1	0	0	0	1	1	0	gactgacagcgtccagagacTtggcagggcctcctgtctgc							TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:140373825delT	ENST00000072869.4	+	1	873	c.695delT	c.(694-696)ctfs	p.L232fs	ADCK2_ENST00000476491.1_Frame_Shift_Del_p.L232fs	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	232	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					GTCCAGAGACTTGGCAGGGCC	0.582													40	119	---	---	---	---						-	140373825	T	-	140373825	7	5	34	1	0	1	0	1	0	0	0	0	288	1609	56	0	697	0	ADCK2	7	140373825	Frame_Shift_Del	DEL	T	TCGA-N9-A4Q1-01A-11D-A28R-08	101916389	140373825	18764838	28	3198										
ZC3H3	23144	broad.mit.edu	37	chr8	144620650	144620650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	ttcgacaggtcacaaccagcGaggcctcccgggcctgcctg	12	16	1	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr8:144620650G>A	ENST00000262577.5	-	2	918	c.887C>T	c.(886-888)tCg>tTg	p.S296L		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	296					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CACAACCAGCGAGGCCTCCCG	0.627													50	98					0	0	1	0	0	A	144620650	G	A	144620650	3	1	34	1	0	0	0	0	1	0	0	0	17627	1059	37	1	2003	1	ZC3H3	8	144620650	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08		144620650	1743372	29	3199										
HEPHL1	341208	broad.mit.edu	37	chr11	93797646	93797646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	attcagttgacaagaaagatGctgttttccagaggagtaac	10	6	1	4			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr11:93797646G>A	ENST00000315765.9	+	4	786	c.778G>A	c.(778-780)Gct>Act	p.A260T		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	260	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CAAGAAAGATGCTGTTTTCCA	0.378													21	3					0	0	1	0	0	A	93797646	G	A	93797646	3	1	34	1	0	0	0	0	1	0	0	0	7095	1319	46	3	792	3	HEPHL1	11	93797646	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08		93797646	41208870	30	3200										
PLEKHG6	55200	broad.mit.edu	37	chr12	6436668	6436670	+	In_Frame_Del	DEL	CTC	CTC	-													0	0	1	0	0	0	1	1	0	ccaccctcccgacccccaagCtcctcaacgccgaagcgccc							TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:6436668_6436670delCTC	ENST00000449001.2	+	14	2317_2319	c.1823_1825delCTC	c.(1822-1827)gct>g	p.AP608del	PLEKHG6_ENST00000304581.8_In_Frame_Del_p.AP170del|PLEKHG6_ENST00000396988.3_In_Frame_Del_p.AP640del|PLEKHG6_ENST00000011684.7_In_Frame_Del_p.AP640del	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	640					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GACCCCCAAGCTCCTCAACGCCG	0.64													50	48	---	---	---	---						-	6436670	CTC	-	6436668	7	5	34	1	0	1	0	1	0	0	0	0	12121	797	28	0	2019	0	PLEKHG6	12	6436668	In_Frame_Del	DEL	CTC	TCGA-N9-A4Q1-01A-11D-A28R-08		6436668	127415227	31	3201										
SOX5	6660	broad.mit.edu	37	chr12	23699267	23699268	+	Frame_Shift_Ins	INS	-	-	T													0	0	1	0	0	0	1	1	0	accatcagaatctccactcaINSgattgaaatccatcattgca							TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:23699267_23699268insT	ENST00000546136.1	-	11	1542_1543	c.1540_1541insA	c.(1540-1542)gagfs	p.E514fs	SOX5_ENST00000541536.1_Frame_Shift_Ins_p.E406fs|SOX5_ENST00000545921.1_Frame_Shift_Ins_p.E517fs|SOX5_ENST00000451604.2_Frame_Shift_Ins_p.E527fs|SOX5_ENST00000381381.2_Frame_Shift_Ins_p.E406fs|SOX5_ENST00000396007.2_Frame_Shift_Ins_p.E141fs|SOX5_ENST00000537393.1_Frame_Shift_Ins_p.E492fs|SOX5_ENST00000309359.1_Frame_Shift_Ins_p.E514fs			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	527				E -> Q (in Ref. 4; AAB49537).	transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						ATCTCCACTCAGATTGAAATCC	0.337													33	43	---	---	---	---						T	23699268	-	T	23699267	7	5	34	1	0	1	1	0	0	0	0	0	15007	188	7	0	727	0	SOX5	12	23699267	Frame_Shift_Ins	INS	-	TCGA-N9-A4Q1-01A-11D-A28R-08	17262599	23699267	110152628	32	3202										
KIF21A	55605	broad.mit.edu	37	chr12	39735322	39735322	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	agtacctttttcatctgattCagaatctgattcatcagaac	5	9	6	4			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:39735322C>A	ENST00000395670.3	-	14	2325	c.1906G>T	c.(1906-1908)Gaa>Taa	p.E636*	KIF21A_ENST00000544797.2_Nonsense_Mutation_p.E623*|KIF21A_ENST00000541463.2_Nonsense_Mutation_p.E623*|KIF21A_ENST00000361961.3_Nonsense_Mutation_p.E623*|KIF21A_ENST00000361418.5_Nonsense_Mutation_p.E636*			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	636					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TCATCTGATTCAGAATCTGAT	0.388													17	19					3.41278e-10	3.7184e-10	1	1	0	A	39735322	C	A	39735322	4	1	34	1	0	0	0	0	0	1	0	0	8329	835	29	2	3218	2	KIF21A	12	39735322	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	16036055	39735322	94116573	33	3203										
ZC3H13	23091	broad.mit.edu	37	chr13	46553965	46553965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aacctctctctctgttgtcaCgacggtctcgctctccatgt	7	15	5	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:46553965C>T	ENST00000242848.4	-	11	2243	c.1895G>A	c.(1894-1896)cGt>cAt	p.R632H	ZC3H13_ENST00000282007.3_Missense_Mutation_p.R632H			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	632	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTGTTGTCACGACGGTCTCG	0.373													16	103					0	0	1	0	0	T	46553965	C	T	46553965	3	4	34	1	0	0	0	0	1	0	0	0	17623	536	19	1	2827	1	ZC3H13	13	46553965	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08		46553965	68615913	34	3204										
RNASEH2B	79621	broad.mit.edu	37	chr13	51530513	51530513	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gaaaaatagcaaaatgactgCagctcagaaggctttggcta	10	7	1	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:51530513C>T	ENST00000336617.3	+	11	1241	c.842C>T	c.(841-843)gCa>gTa	p.A281V	RNASEH2B_ENST00000422660.1_Intron|RNASEH2B_ENST00000495244.2_3'UTR	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	281					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		AAAATGACTGCAGCTCAGAAG	0.289													4	1					0	0	1	0	0	T	51530513	C	T	51530513	3	4	34	1	0	0	0	0	1	0	0	0	13464	710	25	3	884	3	RNASEH2B	13	51530513	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	4976548	51530513	63639365	35	3205										
KLF5	688	broad.mit.edu	37	chr13	73636638	73636638	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	cacaacaggccacttactttCccccgtcaccaccaagctca	4	19	2	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:73636638C>T	ENST00000377687.4	+	2	1437	c.901C>T	c.(901-903)Ccc>Tcc	p.P301S	KLF5_ENST00000539231.1_Missense_Mutation_p.P210S|KLF5_ENST00000477333.1_3'UTR	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	301			P -> S (in a colorectal cancer sample; somatic mutation).		transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding	p.P301S(1)		breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CACTTACTTTCCCCCGTCACC	0.512													28	19					0	0	1	0	0	T	73636638	C	T	73636638	3	4	34	1	0	0	0	0	1	0	0	0	8391	855	30	3	907	3	KLF5	13	73636638	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	22106125	73636638	41533240	36	3206										
COL4A1	1282	broad.mit.edu	37	chr13	110835578	110835578	+	Frame_Shift_Del	DEL	G	G	-													0	0	1	0	0	0	1	1	0	ccggcagtccttctgctccaGgggggcctggtaaaggaaca							TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:110835578delG	ENST00000375820.4	-	27	2064	c.1943delC	c.(1942-1944)ctfs	p.P648fs		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	648	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TTCTGCTCCAGGGGGGCCTGG	0.527													2	4	---	---	---	---						-	110835578	G	-	110835578	7	5	34	1	0	1	0	1	0	0	0	0	3712	1000	35	0	3170	0	COL4A1	13	110835578	Frame_Shift_Del	DEL	G	TCGA-N9-A4Q1-01A-11D-A28R-08	37198940	110835578	4334300	37	3207										
HOMEZ	57594	broad.mit.edu	37	chr14	23746240	23746240	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttttgagcaggtgttcattgCtgtctagctcactggtctgg	12	8	4	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr14:23746240C>G	ENST00000357460.5	-	2	361	c.197G>C	c.(196-198)aGc>aCc	p.S66T	HOMEZ_ENST00000431326.2_Missense_Mutation_p.S68T|HOMEZ_ENST00000561013.1_Missense_Mutation_p.S68T	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	66						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTGTTCATTGCTGTCTAGCTC	0.537													18	60					0	0	1	0	0	G	23746240	C	G	23746240	3	3	34	1	0	0	0	0	1	0	0	0	7321	797	28	5	1459	5	HOMEZ	14	23746240	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08		23746240	83603300	38	3208										
RALGAPA1	253959	broad.mit.edu	37	chr14	36128374	36128374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	cagagggctcatctcttgccGagcttaatacagttttgatt	9	9	2	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr14:36128374G>A	ENST00000258840.6	-	28	4370	c.3980C>T	c.(3979-3981)tCg>tTg	p.S1327L	RALGAPA1_ENST00000382366.3_Missense_Mutation_p.S1293L|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.S1280L|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.S1280L			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1280	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						ATCTCTTGCCGAGCTTAATAC	0.353													12	3					0	0	1	0	0	A	36128374	G	A	36128374	3	1	34	1	0	0	0	0	1	0	0	0	13064	1059	37	1	2480	1	RALGAPA1	14	36128374	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08	12382134	36128374	71221166	39	3209										
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttccttccactcggataagaTgctgaggaggggccagacct	12	11	0	3			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:7578271T>C	ENST00000420246.2	-	6	710	c.578A>G	c.(577-579)cAt>cGt	p.H193R	TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.H193R|TP53_ENST00000445888.2_Missense_Mutation_p.H193R|TP53_ENST00000413465.2_Missense_Mutation_p.H193R|TP53_ENST00000455263.2_Missense_Mutation_p.H193R|TP53_ENST00000359597.4_Missense_Mutation_p.H193R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(80)|p.H193L(42)|p.H193P(18)|p.0?(8)|p.?(6)|p.H61R(4)|p.H100R(4)|p.H100L(4)|p.H61L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.H193fs*16(3)|p.P191fs*53(2)|p.H61P(2)|p.H100P(2)|p.A189fs*53(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P98_E105>Q(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			52	4					0	0	1	0	0	C	7578271	T	C	7578271	3	2	34	1	0	0	0	0	1	0	0	0	16441	1464	51	4	716	4	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-N9-A4Q1-01A-11D-A28R-08		7578271	73616939	40	3210										
ABCA9	10350	broad.mit.edu	37	chr17	67022537	67022537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccttaaatggtagcctatgcCccatttcttcttaaggaaca	6	11	2	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:67022537C>T	ENST00000340001.4	-	16	2333	c.2122G>A	c.(2122-2124)Ggc>Agc	p.G708S	ABCA9_ENST00000370732.2_Missense_Mutation_p.G708S|ABCA9_ENST00000453985.2_Missense_Mutation_p.G708S	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	708	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TAGCCTATGCCCCATTTCTTC	0.423													299	22					0	0	1	0	0	T	67022537	C	T	67022537	3	4	34	1	0	0	0	0	1	0	0	0	39	623	22	3	2848	3	ABCA9	17	67022537	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	59444266	67022537	14172673	41	3211										
ITGB4	3691	broad.mit.edu	37	chr17	73732658	73732658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccgccaagatccacccgggcCtctgcgaggacctacgctcc	10	19	1	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:73732658C>T	ENST00000200181.3	+	16	2060	c.1873C>T	c.(1873-1875)Ctc>Ttc	p.L625F	ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Missense_Mutation_p.L625F|ITGB4_ENST00000450894.3_Missense_Mutation_p.L625F|ITGB4_ENST00000579662.1_Missense_Mutation_p.L625F|ITGB4_ENST00000449880.2_Missense_Mutation_p.L625F	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	625				IHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDEL KRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHK KK -> STRASARTYAPACSARRGAPARRRGARVRNATSRS RWWTSLREARRWWCAAPSGTRMTTAPTATPWKVTAPLGPTA LSWCTRRR (in Ref. 5; CAB61345).	cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCACCCGGGCCTCTGCGAGGA	0.657													12	42					0	0	1	0	0	T	73732658	C	T	73732658	3	4	34	1	0	0	0	0	1	0	0	0	7940	681	24	3	1931	3	ITGB4	17	73732658	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	6710121	73732658	7462552	42	3212										
NCOA6	23054	broad.mit.edu	37	chr20	33328602	33328602	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aatttggccaattttgtccaCttttcctttgcccttactag	5	11	0	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr20:33328602C>T	ENST00000374796.2	-	12	8028	c.5458G>A	c.(5458-5460)Gtg>Atg	p.V1820M	NCOA6_ENST00000359003.2_Missense_Mutation_p.V1820M			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1820	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						ATTTTGTCCACTTTTCCTTTG	0.468													62	46					0	0	1	0	0	T	33328602	C	T	33328602	3	4	34	1	0	0	0	0	1	0	0	0	10279	565	20	3	753	3	NCOA6	20	33328602	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08		33328602	29696918	43	3213										
CTNNBL1	56259	broad.mit.edu	37	chr20	36488358	36488358	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccgaggaggagttctacctcCggcgcctggatgcggggctc	16	13	1	0			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr20:36488358C>T	ENST00000405275.2	+	15	1612	c.1369C>T	c.(1369-1371)Cgg>Tgg	p.R457W	CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000373473.1_Missense_Mutation_p.R297W|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.R484W|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.R232W			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	484					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GTTCTACCTCCGGCGCCTGGA	0.537													30	16					0	0	1	0	0	T	36488358	C	T	36488358	3	4	34	1	0	0	0	0	1	0	0	0	4042	643	23	1	1504	1	CTNNBL1	20	36488358	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	3159756	36488358	26537162	44	3214										
SALL4	57167	broad.mit.edu	37	chr20	50407647	50407647	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tatggggtcaggtacagagaGtgcataggggatgccattgc	16	6	1	1	rs144505438		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr20:50407647G>A	ENST00000217086.4	-	2	1486	c.1375C>T	c.(1375-1377)Ctc>Ttc	p.L459F	SALL4_ENST00000395997.3_Intron|SALL4_ENST00000371539.3_Intron	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	459					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGTACAGAGAGTGCATAGGGG	0.537													33	77					0	0	1	0	0	A	50407647	G	A	50407647	3	1	34	1	0	0	0	0	1	0	0	0	13864	1029	36	3	1798	3	SALL4	20	50407647	Missense_Mutation	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08	13919289	50407647	12617873	45	3215										
BAGE2	85319	broad.mit.edu	37	chr21	11039832	11039832	+	RNA	DEL	G	G	-													0	0	1	0	0	0	1	1	0	agatacccagatgcgacaaaGttactatagactcaaaagca					rs143260277		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr21:11039832delG	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGCGACAAAGTTACTATAGA	0.348													3	6	---	---	---	---						-	11039832	G	-	11039832	6	5	34	0	1	1	0	1	0	0	0	0	1290	1044	36	0		0	BAGE2	21	11039832	RNA	DEL	G	TCGA-N9-A4Q1-01A-11D-A28R-08		11039832	37090063	46	3216										
DSCAM	1826	broad.mit.edu	37	chr21	41741044	41741044	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acctgatacaaaaagtctggCgctgttgctctgcctcgtct	9	12	3	1			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr21:41741044C>T	ENST00000400454.1	-	4	1114	c.637G>A	c.(637-639)Gcc>Acc	p.A213T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	213	Ig-like C2-type 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AAAAGTCTGGCGCTGTTGCTC	0.428													28	38					0	0	1	0	0	T	41741044	C	T	41741044	3	4	34	1	0	0	0	0	1	0	0	0	4794	768	27	1	5521	1	DSCAM	21	41741044	Missense_Mutation	SNP	C	TCGA-N9-A4Q1-01A-11D-A28R-08	30701212	41741044	6388851	47	3217										
HDX	139324	broad.mit.edu	37	chrX	83724416	83724416	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgtatataccagttacaatGacatcattattggcagatgt	7	7	1	2			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chrX:83724416G>T	ENST00000297977.5	-	3	426	c.315C>A	c.(313-315)gtC>gtA	p.V105V	HDX_ENST00000506585.2_Silent_p.V47V|HDX_ENST00000373177.2_Silent_p.V105V	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	105						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CAGTTACAATGACATCATTAT	0.413													22	9					2.37509e-13	2.66741e-13	1	1	0	T	83724416	G	T	83724416	2	4	34	1	0	0	0	0	0	0	0	1	7066	1277	45	2		2	HDX	23	83724416	Silent	SNP	G	TCGA-N9-A4Q1-01A-11D-A28R-08		83724416	71546144	48	3218										
TGFBR3	7049	broad.mit.edu	37	chr1	92178081	92178081	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ggcaaatcccagttcttgttCagccttagtaacagatacct	7	11	2	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr1:92178081C>A	ENST00000212355.4	-	13	2350	c.1885G>T	c.(1885-1887)Gaa>Taa	p.E629*	TGFBR3_ENST00000525962.1_Nonsense_Mutation_p.E629*|TGFBR3_ENST00000370399.2_Nonsense_Mutation_p.E628*	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	629	ZP.				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		AGTTCTTGTTCAGCCTTAGTA	0.383													11	34					0.00010058	0.000102176	1	1	0	A	92178081	C	A	92178081	4	1	35	1	0	0	0	0	0	1	0	0	15882	835	29	2	690	2	TGFBR3	1	92178081	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		92178081	157072540	1	3219										
SEC22B	9554	broad.mit.edu	37	chr1	145109975	145109976	+	RNA	INS	-	-	C													0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	cacatgtgacaggaactttgINSctaaagatctacttgattgg					rs67257307		TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													3	3	---	---	---	---						C	145109976	-	C	145109975	6	5	35	0	1	1	1	0	0	0	0	0	14042	1334	46	0		0	SEC22B	1	145109975	RNA	INS	-	TCGA-N9-A4Q3-01A-11D-A28R-08	52931894	145109975	104140646	2	3220										
FLG	2312	broad.mit.edu	37	chr1	152284630	152284630	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	aggaagcttcatggtgacgtGaccctgagtgcctggagccg	15	10	1	3			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr1:152284630G>A	ENST00000368799.1	-	3	2767	c.2732C>T	c.(2731-2733)tCa>tTa	p.S911L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	911	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTGACGTGACCCTGAGTG	0.572									Ichthyosis				131	492					0	0	1	0	0	A	152284630	G	A	152284630	3	1	35	1	0	0	0	0	1	0	0	0	5954	1294	45	3	9457	3	FLG	1	152284630	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	7174655	152284630	96965991	3	3221										
PPOX	5498	broad.mit.edu	37	chr1	161138253	161138253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	agccatggacagtctctgccGtggagtgtttgcaggcaaca	13	10	1	0	rs41270025		TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr1:161138253G>A	ENST00000367999.4	+	6	769	c.503G>A	c.(502-504)cGt>cAt	p.R168H	PPOX_ENST00000535223.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000352210.5_Missense_Mutation_p.R168H|PPOX_ENST00000495483.1_3'UTR|PPOX_ENST00000544598.1_Intron	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	168			R -> C.		heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGTCTCTGCCGTGGAGTGTTT	0.512													65	69					0	0	1	0	0	A	161138253	G	A	161138253	3	1	35	1	0	0	0	0	1	0	0	0	12396	1145	40	1	521	1	PPOX	1	161138253	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	8853623	161138253	88112368	4	3222										
TMEM63A	9725	broad.mit.edu	37	chr1	226065190	226065190	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tttggccgagttgtagcaatAggagtcgttgggccggtccc	15	9	0	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr1:226065190A>C	ENST00000366835.3	-	3	361	c.91T>G	c.(91-93)Tat>Gat	p.Y31D		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	31						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					TTGTAGCAATAGGAGTCGTTG	0.612											OREG0014291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	22					0	0	1	0	0	C	226065190	A	C	226065190	3	2	35	1	0	0	0	0	1	0	0	0	16249	420	15	4	2420	4	TMEM63A	1	226065190	Missense_Mutation	SNP	A	TCGA-N9-A4Q3-01A-11D-A28R-08	64926937	226065190	23185431	5	3223										
KIF26B	55083	broad.mit.edu	37	chr1	245530500	245530500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ccttggggtcagcaatggggCggaaaagaagagcgggtccc	17	9	1	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr1:245530500C>T	ENST00000407071.2	+	3	1270	c.830C>T	c.(829-831)gCg>gTg	p.A277V	KIF26B_ENST00000479506.1_3'UTR	NM_018012.3	NP_060482.2	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	277					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGCAATGGGGCGGAAAAGAAG	0.617													7	13					0	0	1	0	0	T	245530500	C	T	245530500	3	4	35	1	0	0	0	0	1	0	0	0	8336	768	27	1	840	1	KIF26B	1	245530500	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	19465310	245530500	3720121	6	3224										
IWS1	55677	broad.mit.edu	37	chr2	128262839	128262839	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ctgaggtttaggaagctcctCactttcagaatcactcattc	7	11	4	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr2:128262839C>T	ENST00000295321.4	-	3	899	c.640G>A	c.(640-642)Gag>Aag	p.E214K	IWS1_ENST00000455721.2_Missense_Mutation_p.E221K|IWS1_ENST00000486662.1_5'UTR|AC010976.2_ENST00000599001.1_RNA	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	214	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GGAAGCTCCTCACTTTCAGAA	0.507													50	110					0	0	1	0	0	T	128262839	C	T	128262839	3	4	35	1	0	0	0	0	1	0	0	0	7974	835	29	3	1867	3	IWS1	2	128262839	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		128262839	114936534	7	3225										
LRP2	4036	broad.mit.edu	37	chr2	170058203	170058203	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	caccattgcagataaactcaCgaggtatgcaccttctgtta	7	11	2	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr2:170058203C>T	ENST00000263816.3	-	44	8672	c.8387G>A	c.(8386-8388)cGt>cAt	p.R2796H		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2796	LDL-receptor class A 18.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GATAAACTCACGAGGTATGCA	0.433													38	30					0	0	1	0	0	T	170058203	C	T	170058203	3	4	35	1	0	0	0	0	1	0	0	0	9000	536	19	1	5724	1	LRP2	2	170058203	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	41795364	170058203	73141170	8	3226										
EVX2	344191	broad.mit.edu	37	chr2	176944857	176944857	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	atctggtgagcggagcctcgTccctctggtccggcgggctc	15	14	2	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr2:176944857T>A	ENST00000308618.4	-	3	1545	c.1409A>T	c.(1408-1410)gAc>gTc	p.D470V		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	470						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CGGAGCCTCGTCCCTCTGGTC	0.726													4	2					0	0	1	0	0	A	176944857	T	A	176944857	3	1	35	1	0	0	0	0	1	0	0	0	5322	1667	58	4	23	4	EVX2	2	176944857	Missense_Mutation	SNP	T	TCGA-N9-A4Q3-01A-11D-A28R-08	6886654	176944857	66254516	9	3227										
MLH1	4292	broad.mit.edu	37	chr3	37067374	37067374	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gcagggctaggcagcaagatGaggagatgcttgaactccca	14	9	0	4			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr3:37067374G>A	ENST00000231790.2	+	12	1501	c.1285G>A	c.(1285-1287)Gag>Aag	p.E429K	MLH1_ENST00000435176.1_Missense_Mutation_p.E331K|MLH1_ENST00000536378.1_Missense_Mutation_p.E188K|MLH1_ENST00000455445.2_Missense_Mutation_p.E188K|MLH1_ENST00000539477.1_Missense_Mutation_p.E188K|MLH1_ENST00000458205.2_Missense_Mutation_p.E188K	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	429	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						GCAGCAAGATGAGGAGATGCT	0.517		1	"D, Mis, N, F, S"		"colorectal, endometrial, ovarian, CNS"	"colorectal, endometrial, ovarian, CNS"		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				6	150					0	0	1	0	0	A	37067374	G	A	37067374	3	1	35	1	0	0	0	0	1	0	0	0	9664	1291	45	3	1331	3	MLH1	3	37067374	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08		37067374	160955056	10	3228										
PROS1	5627	broad.mit.edu	37	chr3	93603724	93603724	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tccagcttcgtatacatccaTctagacgagggttaatctaa	7	10	2	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr3:93603724T>C	ENST00000394236.3	-	12	1656	c.1340A>G	c.(1339-1341)gAt>gGt	p.D447G	PROS1_ENST00000407433.1_Missense_Mutation_p.D316G	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	447	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TATACATCCATCTAGACGAGG	0.343													10	27					0	0	1	0	0	C	93603724	T	C	93603724	3	2	35	1	0	0	0	0	1	0	0	0	12609	1435	50	4	706	4	PROS1	3	93603724	Missense_Mutation	SNP	T	TCGA-N9-A4Q3-01A-11D-A28R-08	56536350	93603724	104418706	11	3229										
GPR128	84873	broad.mit.edu	37	chr3	100364805	100364805	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	atagattacaccaagacatgCggctttgtagtttatcaaaa	7	7	1	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr3:100364805C>T	ENST00000273352.3	+	9	1231	c.963C>T	c.(961-963)tgC>tgT	p.C321C	GPR128_ENST00000475887.1_Silent_p.C26C	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	321					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						CCAAGACATGCGGCTTTGTAG	0.308													13	20					0	0	1	0	0	T	100364805	C	T	100364805	2	4	35	1	0	0	0	0	0	0	0	1	6680	776	27	1		1	GPR128	3	100364805	Silent	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	6761081	100364805	97657625	12	3230										
ATR	545	broad.mit.edu	37	chr3	142168367	142168367	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	acatgtccttcaatagataaCggcagtcctgtcactctatt	6	11	3	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr3:142168367C>T	ENST00000350721.4	-	47	7960	c.7839G>A	c.(7837-7839)ccG>ccA	p.P2613P	ATR_ENST00000383101.3_Silent_p.P2549P	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2613	FATC.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						CAATAGATAACGGCAGTCCTG	0.398								Other conserved DNA damage response genes					19	18					0	0	1	0	0	T	142168367	C	T	142168367	2	4	35	1	0	0	0	0	0	0	0	1	1202	523	19	1		1	ATR	3	142168367	Silent	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	41803562	142168367	55854063	13	3231										
LMBRD2	92255	broad.mit.edu	37	chr5	36118007	36118007	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ccatggtcgcaaaagacattCccagtaccattctagaagac	7	12	1	3			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr5:36118007C>A	ENST00000296603.4	-	10	1594	c.1132G>T	c.(1132-1134)Gaa>Taa	p.E378*		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	378						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAAGACATTCCCAGTACCAT	0.358													22	7					6.33239e-15	6.98746e-15	1	1	0	A	36118007	C	A	36118007	4	1	35	1	0	0	0	0	0	1	0	0	8883	864	30	2	991	2	LMBRD2	5	36118007	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		36118007	144797253	14	3232										
RANBP17	64901	broad.mit.edu	37	chr5	170648770	170648770	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tatatttcttagatcccagcGtttgaattttgatgtatcat	6	6	2	3			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr5:170648770G>A	ENST00000523189.1	+	22	2512	c.2348G>A	c.(2347-2349)cGt>cAt	p.R783H	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	783					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGATCCCAGCGTTTGAATTTT	0.328			T	TRD@	ALL								3	30					0	0	1	0	0	A	170648770	G	A	170648770	3	1	35	1	0	0	0	0	1	0	0	0	13078	1145	40	1	2434	1	RANBP17	5	170648770	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	134530763	170648770	10266490	15	3233										
DGKB	1607	broad.mit.edu	37	chr7	14517813	14517813	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tgaatttctctgggtgttttTctctcatgatgtggaatctg	10	6	4	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr7:14517813T>C	ENST00000403951.2	-	21	2230	c.1811A>G	c.(1810-1812)gAa>gGa	p.E604G	DGKB_ENST00000402815.1_Missense_Mutation_p.E603G|DGKB_ENST00000399322.3_Missense_Mutation_p.E604G|DGKB_ENST00000444700.2_Missense_Mutation_p.E585G|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.E604G|DGKB_ENST00000407950.1_Missense_Mutation_p.E596G|DGKB_ENST00000406247.3_Missense_Mutation_p.E604G			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	604					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TGGGTGTTTTTCTCTCATGAT	0.343													4	5					0	0	1	0	0	C	14517813	T	C	14517813	3	2	35	1	0	0	0	0	1	0	0	0	4494	1783	62	4	642	4	DGKB	7	14517813	Missense_Mutation	SNP	T	TCGA-N9-A4Q3-01A-11D-A28R-08		14517813	144620850	16	3234										
FERD3L	222894	broad.mit.edu	37	chr7	19184612	19184612	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	caaacgtgggcaccttcctcCgcagctggtcaaaggcctcg	11	15	1	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr7:19184612C>T	ENST00000275461.3	-	1	432	c.374G>A	c.(373-375)cGg>cAg	p.R125Q	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	125	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CACCTTCCTCCGCAGCTGGTC	0.587													27	20					0	0	1	0	0	T	19184612	C	T	19184612	3	4	35	1	0	0	0	0	1	0	0	0	5848	652	23	1	130	1	FERD3L	7	19184612	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	4666799	19184612	139954051	17	3235										
CLIP2	7461	broad.mit.edu	37	chr7	73811495	73811495	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gccgtgaggtacacaaggctGagtggcggatcaaggagcag	17	8	1	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr7:73811495G>C	ENST00000223398.6	+	14	3139	c.2812G>C	c.(2812-2814)Gag>Cag	p.E938Q	CLIP2_ENST00000395060.1_Missense_Mutation_p.E938Q|CLIP2_ENST00000361545.5_Missense_Mutation_p.E903Q	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	938						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						ACACAAGGCTGAGTGGCGGAT	0.637													13	101					0	0	1	0	0	C	73811495	G	C	73811495	3	2	35	1	0	0	0	0	1	0	0	0	3556	1291	45	2	2862	2	CLIP2	7	73811495	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	54626883	73811495	85327168	18	3236										
FER1L6	654463	broad.mit.edu	37	chr8	124985750	124985750	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ggggaccgtgtacaaccaacCtggtaagaaaacatcacctc	9	12	1	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr8:124985750C>G	ENST00000522917.1	+	7	730	c.524C>G	c.(523-525)cCt>cGt	p.P175R	FER1L6_ENST00000399018.1_Missense_Mutation_p.P175R	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	175						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TACAACCAACCTGGTAAGAAA	0.468													6	33					0	0	1	0	0	G	124985750	C	G	124985750	3	3	35	1	0	0	0	0	1	0	0	0	5847	681	24	5	546	5	FER1L6	8	124985750	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		124985750	21378272	19	3237										
CYP26A1	0	broad.mit.edu	37	chr10	94836425	94836425	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	cccagttccaggagggtttcGggttgctctgaagacttttg	13	9	1	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr10:94836425G>A	ENST00000371531.1	+	6	1295	c.917G>A	c.(916-918)cGg>cAg	p.R306Q	CYP26A1_ENST00000224356.4_Missense_Mutation_p.R375Q|CYP26A1_ENST00000394139.1_Missense_Mutation_p.R306Q	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	375					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				GGAGGGTTTCGGGTTGCTCTG	0.403													15	40					0	0	1	0	0	A	94836425	G	A	94836425	3	1	35	1	0	0	0	0	1	0	0	0	4178	1116	39	1	1146	1	CYP26A1	10	94836425	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08		94836425	40698322	20	3238										
IGHMBP2	3508	broad.mit.edu	37	chr11	68700847	68700847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gagggtggtgcggacactgaCggtgcagtaccgcatgcacc	16	11	0	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr11:68700847C>T	ENST00000255078.3	+	9	1427	c.1316C>T	c.(1315-1317)aCg>aTg	p.T439M		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	439					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CGGACACTGACGGTGCAGTAC	0.642													5	14					0	0	1	0	0	T	68700847	C	T	68700847	3	4	35	1	0	0	0	0	1	0	0	0	7634	536	19	1	1350	1	IGHMBP2	11	68700847	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		68700847	66305669	21	3239										
SERPINH1	871	broad.mit.edu	37	chr11	75282848	75282848	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	acacctggctgggctgggccTgactgaggccattgacaaga	14	11	0	4			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr11:75282848T>G	ENST00000524558.1	+	5	2412	c.977T>G	c.(976-978)cTg>cGg	p.L326R	SERPINH1_ENST00000525876.1_Missense_Mutation_p.L109R|SERPINH1_ENST00000358171.3_Missense_Mutation_p.L326R|SERPINH1_ENST00000533603.1_Missense_Mutation_p.L326R			P50454	SERPH_HUMAN	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	326					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			endometrium(4)|large_intestine(3)|liver(1)|lung(4)|ovary(2)|stomach(1)	15	Ovarian(111;0.11)					GGGCTGGGCCTGACTGAGGCC	0.597													23	17					0	0	1	0	0	G	75282848	T	G	75282848	3	3	35	1	0	0	0	0	1	0	0	0	14170	1580	55	4	991	4	SERPINH1	11	75282848	Missense_Mutation	SNP	T	TCGA-N9-A4Q3-01A-11D-A28R-08	6582001	75282848	59723668	22	3240										
VWF	7450	broad.mit.edu	37	chr12	6105256	6105256	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gccttgctccagggctgcagGcaccattatggagaatcacc	11	13	1	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr12:6105256G>A	ENST00000261405.5	-	35	6229	c.5975C>T	c.(5974-5976)gCc>gTc	p.A1992V		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1992	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AGGGCTGCAGGCACCATTATG	0.522													4	63					0	0	1	0	0	A	6105256	G	A	6105256	3	1	35	1	0	0	0	0	1	0	0	0	17305	1203	42	3	2538	3	VWF	12	6105256	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08		6105256	127746639	23	3241										
DPPA3	359787	broad.mit.edu	37	chr12	7867853	7867853	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tcaacgctagtagcgaatctGtttcccctctatcggaagct	8	12	3	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr12:7867853G>T	ENST00000345088.2	+	2	274	c.157G>T	c.(157-159)Gtt>Ttt	p.V53F		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	53						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		TAGCGAATCTGTTTCCCCTCT	0.468													28	98					4.87955e-14	5.29308e-14	1	1	0	T	7867853	G	T	7867853	3	4	35	1	0	0	0	0	1	0	0	0	4761	1377	48	5	163	5	DPPA3	12	7867853	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	1762597	7867853	125984042	24	3242										
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			9	7					3.86212e-05	3.9867e-05	1	1	0	A	25398284	C	A	25398284	3	1	35	1	0	0	0	0	1	0	0	0	8480	507	18	5	671	5	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	17530431	25398284	108453611	25	3243										
FNDC3A	22862	broad.mit.edu	37	chr13	49772644	49772644	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	taagctgaaatggggagaagGaactccaaagacattgtcaa	11	6	1	3			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr13:49772644G>T	ENST00000492622.2	+	23	3226	c.2921G>T	c.(2920-2922)gGa>gTa	p.G974V	FNDC3A_ENST00000541916.1_Missense_Mutation_p.G974V|FNDC3A_ENST00000398316.3_Missense_Mutation_p.G918V	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	974	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TGGGGAGAAGGAACTCCAAAG	0.403													21	50					1.87028e-06	1.96226e-06	1	1	0	T	49772644	G	T	49772644	3	4	35	1	0	0	0	0	1	0	0	0	6001	1174	41	2	3018	2	FNDC3A	13	49772644	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08		49772644	65397234	26	3244										
PIBF1	10464	broad.mit.edu	37	chr13	73357694	73357694	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	attagtttagaaacaacagtTcctacggatgatatttcctc	6	8	0	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr13:73357694T>C	ENST00000326291.6	+	2	425	c.87T>C	c.(85-87)gtT>gtC	p.V29V		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	29						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		AAACAACAGTTCCTACGGATG	0.348													16	74					0	0	1	0	0	C	73357694	T	C	73357694	2	2	35	1	0	0	0	0	0	0	0	1	11926	1770	62	4		4	PIBF1	13	73357694	Silent	SNP	T	TCGA-N9-A4Q3-01A-11D-A28R-08	23585050	73357694	41812184	27	3245										
CDC42BPB	9578	broad.mit.edu	37	chr14	103418917	103418917	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gtagggctggagaaggacttGatgctgaactggtgagcttt	16	5	0	4			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr14:103418917G>C	ENST00000361246.2	-	24	3378	c.3090C>G	c.(3088-3090)atC>atG	p.I1030M		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1030					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		AGAAGGACTTGATGCTGAACT	0.547													7	16					0	0	1	0	0	C	103418917	G	C	103418917	3	2	35	1	0	0	0	0	1	0	0	0	3095	1280	45	2	2101	2	CDC42BPB	14	103418917	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08		103418917	3930623	28	3246										
TP53	7157	broad.mit.edu	37	chr17	7579591	7579591	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gcttgggacggcaagggggaCtgtagatgggtgaaaagagc	19	5	0	3			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr17:7579591C>G	ENST00000420246.2	-	4	229		c.e4-1		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(8)|p.0?(8)|p.L35fs*10(3)|p.S33fs*10(1)|p.P13fs*18(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAAGGGGGACTGTAGATGGG	0.592		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			54	18					0	0	1	0	0	G	7579591	C	G	7579591	5	3	35	1	0	0	0	0	0	0	1	0	16441	579	20	5	1206	5	TP53	17	7579591	Splice_Site	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		7579591	73615619	29	3247										
PSMD11	5717	broad.mit.edu	37	chr17	30806375	30806375	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gaatctgatccgagtcattgAgcctttttccagagtacagg	10	9	2	3	rs1803015		TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr17:30806375A>G	ENST00000261712.3	+	10	1282	c.1019A>G	c.(1018-1020)gAg>gGg	p.E340G	PSMD11_ENST00000457654.2_Missense_Mutation_p.E340G	NM_001270482.1|NM_002815.3	NP_001257411.1|NP_002806.2	O00231	PSD11_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	340	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			CGAGTCATTGAGCCTTTTTCC	0.507													76	8					0	0	1	0	0	G	30806375	A	G	30806375	3	3	35	1	0	0	0	0	1	0	0	0	12742	304	11	4	1057	4	PSMD11	17	30806375	Missense_Mutation	SNP	A	TCGA-N9-A4Q3-01A-11D-A28R-08	23226784	30806375	50388835	30	3248										
KRT33B	3884	broad.mit.edu	37	chr17	39521743	39521743	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	acctggttcaggtccacagcGggagcagcgtccacctccac	11	16	1	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr17:39521743G>A	ENST00000251646.3	-	4	700	c.651C>T	c.(649-651)ccC>ccT	p.P217P		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	217	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				GGTCCACAGCGGGAGCAGCGT	0.562													5	40					0	0	1	0	0	A	39521743	G	A	39521743	2	1	35	1	0	0	0	0	0	0	0	1	8512	1103	39	1		1	KRT33B	17	39521743	Silent	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	8715368	39521743	41673467	31	3249										
MPO	4353	broad.mit.edu	37	chr17	56355451	56355451	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	cggggcaagccgggcaggagCggaagaacgggatgcagtcg	20	9	0	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr17:56355451C>A	ENST00000340482.3	-	6	1213	c.1037G>T	c.(1036-1038)cGc>cTc	p.R346L	MPO_ENST00000225275.3_Missense_Mutation_p.R314L|MPO_ENST00000578493.1_5'UTR			P05164	PERM_HUMAN	myeloperoxidase	314					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	CGGGCAGGAGCGGAAGAACGG	0.622													75	4					3.83446e-41	4.38224e-41	1	1	0	A	56355451	C	A	56355451	3	1	35	1	0	0	0	0	1	0	0	0	9780	768	27	5	1320	5	MPO	17	56355451	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	16833708	56355451	24839759	32	3250										
PITPNC1	26207	broad.mit.edu	37	chr17	65688807	65688807	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tccccctgctgccttcttccGtccgcagtgcgccttctagt	8	18	2	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr17:65688807G>A	ENST00000335257.6	+	9	1149	c.802G>A	c.(802-804)Gtc>Atc	p.V268I	PITPNC1_ENST00000581322.1_Missense_Mutation_p.V268I|PITPNC1_ENST00000299954.9_3'UTR|PITPNC1_ENST00000580974.1_3'UTR			Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein, cytoplasmic 1	268					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding	p.V268I(2)		breast(1)|kidney(2)|large_intestine(3)|liver(2)|lung(4)|prostate(2)|skin(3)	17	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			GCCTTCTTCCGTCCGCAGTGC	0.557													102	15					0	0	1	0	0	A	65688807	G	A	65688807	3	1	35	1	0	0	0	0	1	0	0	0	11996	1145	40	1	959	1	PITPNC1	17	65688807	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	9333356	65688807	15506403	33	3251										
EMR1	2015	broad.mit.edu	37	chr19	6919630	6919630	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	atgagcgcttcttcaaagacCaccaggctcccttgaccacc	7	16	2	3			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr19:6919630C>A	ENST00000312053.4	+	13	1529	c.1492C>A	c.(1492-1494)Cac>Aac	p.H498N	EMR1_ENST00000250572.8_Missense_Mutation_p.H498N|EMR1_ENST00000450315.3_Missense_Mutation_p.H321N|EMR1_ENST00000381407.5_Missense_Mutation_p.H357N|EMR1_ENST00000381404.4_Missense_Mutation_p.H446N	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	498	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTTCAAAGACCACCAGGCTCC	0.483													27	57					8.24728e-16	9.26011e-16	1	1	0	A	6919630	C	A	6919630	3	1	35	1	0	0	0	0	1	0	0	0	5132	594	21	5	1542	5	EMR1	19	6919630	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		6919630	52209353	34	3252										
PRAM1	84106	broad.mit.edu	37	chr19	8555521	8555521	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	agcatctcctcattgctggtGaactcgatcacctccaggat	8	13	3	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr19:8555521G>A	ENST00000423345.4	-	7	2383	c.1863C>T	c.(1861-1863)ttC>ttT	p.F621F	PRAM1_ENST00000255612.3_Silent_p.F620F			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	669							lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						CATTGCTGGTGAACTCGATCA	0.662													4	25					0	0	1	0	0	A	8555521	G	A	8555521	2	1	35	1	0	0	0	0	0	0	0	1	12471	1281	45	3		3	PRAM1	19	8555521	Silent	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	1635891	8555521	50573462	35	3253										
PRAM1	84106	broad.mit.edu	37	chr19	8564555	8564555	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ttagctcaggctgggagaacTtcttcagtttaccaaactca	8	10	4	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr19:8564555T>A	ENST00000423345.4	-	2	657	c.137A>T	c.(136-138)aAg>aTg	p.K46M	PRAM1_ENST00000255612.3_Missense_Mutation_p.K46M			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	46	Pro-rich.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						CTGGGAGAACTTCTTCAGTTT	0.592													21	133					0	0	1	0	0	A	8564555	T	A	8564555	3	1	35	1	0	0	0	0	1	0	0	0	12471	1609	56	4	1908	4	PRAM1	19	8564555	Missense_Mutation	SNP	T	TCGA-N9-A4Q3-01A-11D-A28R-08	9034	8564555	50564428	36	3254										
CCDC130	81576	broad.mit.edu	37	chr19	13873409	13873409	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tctcctctcctctagcctacGaggacaagcagaaactcaag	7	14	4	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr19:13873409G>A	ENST00000586600.1	+	11	1221	c.718G>A	c.(718-720)Gag>Aag	p.E240K	CCDC130_ENST00000587019.1_3'UTR|CCDC130_ENST00000221554.8_Missense_Mutation_p.E240K			P13994	CC130_HUMAN	coiled-coil domain containing 130	240					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			TCTAGCCTACGAGGACAAGCA	0.632													14	15					0	0	1	0	0	A	13873409	G	A	13873409	3	1	35	1	0	0	0	0	1	0	0	0	2784	1059	37	1	752	1	CCDC130	19	13873409	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	5308854	13873409	45255574	37	3255										
NDUFA13	51079	broad.mit.edu	37	chr19	19626917	19626917	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ccagagctttcccgcgcggtCggatagttacactactgtcc	10	14	0	1			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr19:19626917C>T	ENST00000252576.5	+	1	119	c.119C>T	c.(118-120)tCg>tTg	p.S40L	NDUFA13_ENST00000507754.3_5'UTR	NM_015965.6	NP_057049.5			NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	12						CCCGCGCGGTCGGATAGTTAC	0.622													13	52					0	0	1	0	0	T	19626917	C	T	19626917	3	4	35	1	0	0	0	0	1	0	0	0	10309	899	31	1		1	NDUFA13	19	19626917	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	5753508	19626917	39502066	38	3256										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715971	52715971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	cctgtgctcagatgacacccCcatggtgcggcgggccgcag	14	15	1	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr19:52715971C>G	ENST00000322088.6	+	5	594	c.536C>G	c.(535-537)cCc>cGc	p.P179R	PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124R	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612			Mis		clear cell ovarian carcinoma								37	42					0	0	1	0	0	G	52715971	C	G	52715971	3	3	35	1	0	0	0	0	1	0	0	0	12430	623	22	5	554	5	PPP2R1A	19	52715971	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08	33089054	52715971	6413012	39	3257										
TCF15	6939	broad.mit.edu	37	chr20	590483	590483	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	cacggctgcccgtcgtcggcCgagtcgcccagcagcagcac	13	18	0	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr20:590483C>T	ENST00000246080.3	-	1	559	c.399G>A	c.(397-399)tcG>tcA	p.S133S		NM_004609.3	NP_004600.2	Q12870	TCF15_HUMAN	transcription factor 15 (basic helix-loop-helix)	133					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|lung(2)|prostate(1)	4		Breast(17;0.231)				CGTCGTCGGCCGAGTCGCCCA	0.741													7	6					0	0	1	0	0	T	590483	C	T	590483	2	4	35	1	0	0	0	0	0	0	0	1	15747	639	23	1		1	TCF15	20	590483	Silent	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		590483	62435037	40	3258										
DSN1	79980	broad.mit.edu	37	chr20	35399395	35399409	+	In_Frame_Del	DEL	TGAAGGGACTTCGAC	TGAAGGGACTTCGAC	-													0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	attgttcttgaggagacaaaTgaagggacttcgactgaagt							TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr20:35399395_35399409delTGAAGGGACTTCGAC	ENST00000426836.1	-	3	594_608	c.222_236delGTCGAAGTCCCTTCA	c.(220-237)cat>ca	p.QSKSLH74del	DSN1_ENST00000373734.4_Intron|DSN1_ENST00000373740.3_Intron|DSN1_ENST00000473615.1_Intron|DSN1_ENST00000373745.3_In_Frame_Del_p.QSKSLH74del|DSN1_ENST00000373750.4_In_Frame_Del_p.QSKSLH74del|DSN1_ENST00000448110.1_In_Frame_Del_p.QSKSLH58del	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	74					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				AGGAGACAAATGAAGGGACTTCGACTGAAGTCTTT	0.498													45	141	---	---	---	---						-	35399409	TGAAGGGACTTCGAC	-	35399395	7	5	35	1	0	1	0	1	0	0	0	0	4806	1464	51	0	870	0	DSN1	20	35399395	In_Frame_Del	DEL	TGAAGGGACTTCGAC	TCGA-N9-A4Q3-01A-11D-A28R-08	34808912	35399395	27626125	41	3259										
BAGE2	85319	broad.mit.edu	37	chr21	11071214	11071215	+	RNA	INS	-	-	C													0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	agagagagggcagaccaattINSagggcttcaggtgccaagaa					rs113940337		TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chr21:11071214_11071215insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gcagaccaattagggcttcagg	0.406													2	4	---	---	---	---						C	11071215	-	C	11071214	6	5	35	0	1	1	1	0	0	0	0	0	1290	1769	61	0		0	BAGE2	21	11071214	RNA	INS	-	TCGA-N9-A4Q3-01A-11D-A28R-08		11071214	37058681	42	3260										
MXRA5	25878	broad.mit.edu	37	chrX	3235472	3235472	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gcggatctgggtaccgtcccCgagcacccagcgcacgctgg	14	16	1	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chrX:3235472C>T	ENST00000217939.6	-	6	6404	c.6250G>A	c.(6250-6252)Ggg>Agg	p.G2084R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2084	Ig-like C2-type 5.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTACCGTCCCCGAGCACCCAG	0.642													13	10					0	0	1	0	0	T	3235472	C	T	3235472	3	4	35	1	0	0	0	0	1	0	0	0	10050	652	23	1	2244	1	MXRA5	23	3235472	Missense_Mutation	SNP	C	TCGA-N9-A4Q3-01A-11D-A28R-08		3235472	152035088	43	3261										
KAL1	3730	broad.mit.edu	37	chrX	8553429	8553429	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tcagtcagttgaactcgctcGtctgtggtctgaggggacat	13	9	4	2			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chrX:8553429G>A	ENST00000262648.3	-	6	884	c.735C>T	c.(733-735)gaC>gaT	p.D245D		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	245	Fibronectin type-III 1.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity	p.D245D(1)		breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GAACTCGCTCGTCTGTGGTCT	0.488													36	39					0	0	1	0	0	A	8553429	G	A	8553429	2	1	35	1	0	0	0	0	0	0	0	1	8017	1136	40	1		1	KAL1	23	8553429	Silent	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	5317957	8553429	146717131	44	3262										
FANCB	2187	broad.mit.edu	37	chrX	14862842	14862843	+	Frame_Shift_Ins	INS	-	-	A													0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	tggaatgctgcaagaagtgcINSaaaaagatcttccatgtgct							TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chrX:14862842_14862843insA	ENST00000398334.1	-	9	2214_2215	c.1947_1948insT	c.(1945-1950)ttcactfs	p.T650fs	FANCB_ENST00000324138.3_Frame_Shift_Ins_p.T650fs	NM_001018113.1	NP_001018123.1	Q8NB91	FANCB_HUMAN	Fanconi anemia, complementation group B	650					DNA repair	nucleoplasm				NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24	Hepatocellular(33;0.183)					GCAAGAAGTGCAAAAAGATCTT	0.347								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				16	87	---	---	---	---						A	14862843	-	A	14862842	7	5	35	1	0	1	1	0	0	0	0	0	5695	710	25	0	639	0	FANCB	23	14862842	Frame_Shift_Ins	INS	-	TCGA-N9-A4Q3-01A-11D-A28R-08	6309413	14862842	140407718	45	3263										
USP9X	8239	broad.mit.edu	37	chrX	41055894	41055895	+	Frame_Shift_Ins	INS	-	-	A													0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	ggcgactactttactcttttINSaagacaccttcttaattacg							TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chrX:41055894_41055895insA	ENST00000324545.7	+	28	4769_4770	c.4136_4137insA	c.(4135-4137)tagfs	p.*1379fs	USP9X_ENST00000378308.2_Frame_Shift_Ins_p.*1379fs	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1379					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TTTACTCTTTTAAGACACCTTC	0.347													14	42	---	---	---	---						A	41055895	-	A	41055894	7	5	35	1	0	1	1	0	0	0	0	0	17149	1764	61	0	4242	0	USP9X	23	41055894	Frame_Shift_Ins	INS	-	TCGA-N9-A4Q3-01A-11D-A28R-08	26193052	41055894	114214666	46	3264										
AIFM1	9131	broad.mit.edu	37	chrX	129299534	129299534	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127659574468085	6	1	1.63779527559055	2.94803149606299	1.34001431639227	0.592074592074592	1	0	gggtcagtcacctgggagccGgttcctctgcctcgggcttc	14	14	3	0			TCGA-N9-A4Q3-01A-11D-A28R-08	TCGA-N9-A4Q3-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5063826c-65ef-461a-af85-577824a4bd4e	41b977af-1f55-410f-8858-f88c7c739a3f	g.chrX:129299534G>A	ENST00000287295.3	-	1	327	c.97C>T	c.(97-99)Cgg>Tgg	p.R33W	AIFM1_ENST00000535724.1_5'UTR|AIFM1_ENST00000346424.2_Missense_Mutation_p.R33W|AIFM1_ENST00000319908.3_Missense_Mutation_p.R33W	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	33					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						CCTGGGAGCCGGTTCCTCTGC	0.672													4	8					0	0	1	0	0	A	129299534	G	A	129299534	3	1	35	1	0	0	0	0	1	0	0	0	423	1115	39	1	1955	1	AIFM1	23	129299534	Missense_Mutation	SNP	G	TCGA-N9-A4Q3-01A-11D-A28R-08	88243640	129299534	25971026	47	3265										
SDC3	9672	broad.mit.edu	37	chr1	31347424	31347424	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	attgtggtcaggaaggtctcTggagttggggtctgcagaga	17	5	3	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:31347424T>C	ENST00000336798.7	-	2	2200	c.708A>G	c.(706-708)ccA>ccG	p.P236P	SDC3_ENST00000339394.6_Silent_p.P294P			O75056	SDC3_HUMAN	syndecan 3	294	Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		GGAAGGTCTCTGGAGTTGGGG	0.597													69	64					0	0	1	0	0	C	31347424	T	C	31347424	2	2	36	1	0	0	0	0	0	0	0	1	14006	1567	55	4		4	SDC3	1	31347424	Silent	SNP	T	TCGA-N9-A4Q4-01A-11D-A28R-08		31347424	217903197	1	3266										
PUM1	9698	broad.mit.edu	37	chr1	31439111	31439111	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tgctccatttgctgaagctgCggctgctgcaacagctatga	11	11	0	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:31439111C>T	ENST00000373747.3	-	13	1906	c.1807G>A	c.(1807-1809)Gca>Aca	p.A603T	PUM1_ENST00000373742.2_Missense_Mutation_p.A543T|PUM1_ENST00000257075.5_Missense_Mutation_p.A602T|PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000440538.2_Intron|PUM1_ENST00000426105.2_Missense_Mutation_p.A602T|PUM1_ENST00000424085.2_Missense_Mutation_p.A360T|PUM1_ENST00000423018.2_Missense_Mutation_p.A458T|PUM1_ENST00000373741.4_Missense_Mutation_p.A638T	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	602	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GCTGAAGCTGCGGCTGCTGCA	0.473													26	65					0	0	1	0	0	T	31439111	C	T	31439111	3	4	36	1	0	0	0	0	1	0	0	0	12876	768	27	1	1802	1	PUM1	1	31439111	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	91687	31439111	217811510	2	3267										
YARS	8565	broad.mit.edu	37	chr1	33245093	33245093	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	agcagagcctgccggagggtCcagaggttcaacctggcggt	16	11	1	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:33245093C>A	ENST00000373477.4	-	12	2274	c.1366G>T	c.(1366-1368)Gac>Tac	p.D456Y	YARS_ENST00000469100.1_5'UTR	NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	456	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GCCGGAGGGTCCAGAGGTTCA	0.542													49	39					2.64894e-19	3.21657e-19	1	1	0	A	33245093	C	A	33245093	3	1	36	1	0	0	0	0	1	0	0	0	17526	855	30	2	228	2	YARS	1	33245093	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	1805982	33245093	216005528	3	3268										
OR6K2	81448	broad.mit.edu	37	chr1	158670014	158670014	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	caaacacagcaacttaaagtCagttgggtacatagcttggg	10	8	1	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:158670014C>A	ENST00000359610.2	-	1	472	c.429G>T	c.(427-429)ctG>ctT	p.L143L		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					AACTTAAAGTCAGTTGGGTAC	0.463													29	75					2.65835e-16	3.11668e-16	1	1	0	A	158670014	C	A	158670014	2	1	36	1	0	0	0	0	0	0	0	1	11248	813	29	2		2	OR6K2	1	158670014	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	125424921	158670014	90580607	4	3269										
PLXNA2	5362	broad.mit.edu	37	chr1	208315676	208315677	+	Frame_Shift_Ins	INS	-	-	TC													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tggatgttagcacttacctgINStctctcagacatgacgtaca							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:208315676_208315677insTC	ENST00000367033.3	-	4	2260_2261	c.1503_1504insGA	c.(1501-1506)agaggtfs	p.G502fs		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	502	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCACTTACCTGTCTCTCAGACA	0.49													17	72	---	---	---	---						TC	208315677	-	TC	208315676	7	5	36	1	0	1	1	0	0	0	0	0	12167	1386	48	0	4296	0	PLXNA2	1	208315676	Frame_Shift_Ins	INS	-	TCGA-N9-A4Q4-01A-11D-A28R-08	49645662	208315676	40934945	5	3270										
OR2M5	127059	broad.mit.edu	37	chr1	248308944	248308944	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gatgctgtagcgacattttcCttctcctactgtgggtctcg	10	11	2	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr1:248308944C>A	ENST00000366476.1	+	1	495	c.495C>A	c.(493-495)tcC>tcA	p.S165S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CGACATTTTCCTTCTCCTACT	0.448													134	141					9.186e-65	1.17858e-64	1	1	0	A	248308944	C	A	248308944	2	1	36	1	0	0	0	0	0	0	0	1	11060	668	24	5		5	OR2M5	1	248308944	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	39993268	248308944	941677	6	3271										
FN1	2335	broad.mit.edu	37	chr2	216238117	216238117	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	aatgacataaattgtatattCggttcccggttccaggcctg	9	9	0	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:216238117C>T	ENST00000354785.4	-	39	6544	c.6175G>A	c.(6175-6177)Gaa>Aaa	p.E2059K	FN1_ENST00000432072.2_Missense_Mutation_p.E1969K|FN1_ENST00000357009.2_Missense_Mutation_p.E1968K|FN1_ENST00000345488.5_Missense_Mutation_p.E1968K|FN1_ENST00000346544.3_Missense_Mutation_p.E1968K|FN1_ENST00000359671.1_Missense_Mutation_p.E1968K|FN1_ENST00000336916.4_Missense_Mutation_p.E1968K|FN1_ENST00000446046.1_Missense_Mutation_p.E1968K|FN1_ENST00000443816.1_Missense_Mutation_p.E1878K|FN1_ENST00000356005.4_Missense_Mutation_p.E1878K|FN1_ENST00000357867.4_Missense_Mutation_p.E1878K|FN1_ENST00000421182.1_Missense_Mutation_p.E1878K|FN1_ENST00000323926.6_Missense_Mutation_p.E2059K			P02751	FINC_HUMAN	fibronectin 1	1968	Connecting strand 3 (CS-3) (V region).				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding	p.E1968K(1)	FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTGTATATTCGGTTCCCGGT	0.468													4	84					0	0	1	0	0	T	216238117	C	T	216238117	3	4	36	1	0	0	0	0	1	0	0	0	5994	893	31	1	1290	1	FN1	2	216238117	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		216238117	26961256	7	3272										
SPHKAP	80309	broad.mit.edu	37	chr2	228882546	228882546	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tctttaagctcagggtgctcGtccgtcttcctcttgatctc	8	13	5	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr2:228882546G>A	ENST00000392056.3	-	7	3070	c.3024C>T	c.(3022-3024)gaC>gaT	p.D1008D	SPHKAP_ENST00000344657.5_Silent_p.D1008D	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1008						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGGGTGCTCGTCCGTCTTCC	0.517													45	48					0	0	1	0	0	A	228882546	G	A	228882546	2	1	36	1	0	0	0	0	0	0	0	1	15103	1136	40	1		1	SPHKAP	2	228882546	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	12644429	228882546	14316827	8	3273										
SH3TC2	79628	broad.mit.edu	37	chr5	148389871	148389871	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	atgatgcctgtggcgggtccCattgaagaacacatcacctg	11	11	1	3			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr5:148389871C>A	ENST00000538184.1	-	10	2818	c.1930G>T	c.(1930-1932)Ggg>Tgg	p.G644W	SH3TC2_ENST00000515425.1_Missense_Mutation_p.G1097W|SH3TC2_ENST00000512049.1_Missense_Mutation_p.G1090W			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1097							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCGGGTCCCATTGAAGAAC	0.552													17	0					2.35188e-11	2.62177e-11	1	1	0	A	148389871	C	A	148389871	3	1	36	1	0	0	0	0	1	0	0	0	14316	594	21	5	593	5	SH3TC2	5	148389871	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		148389871	32525389	9	3274										
HIVEP1	3096	broad.mit.edu	37	chr6	12121828	12121828	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	aaggaccttcaggtgacaaaCgtacagccactttcagccaa	8	12	2	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr6:12121828C>A	ENST00000379388.2	+	4	2132	c.1800C>A	c.(1798-1800)aaC>aaA	p.N600K		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	600					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGTGACAAACGTACAGCCAC	0.498													51	49					6.32628e-17	7.54714e-17	1	1	0	A	12121828	C	A	12121828	3	1	36	1	0	0	0	0	1	0	0	0	7226	535	19	5	1810	5	HIVEP1	6	12121828	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		12121828	158993239	10	3275										
UTRN	7402	broad.mit.edu	37	chr6	144757091	144757091	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	agtacagcgcctgaggaggaGcatgagagtccccgagctga	15	10	0	3			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr6:144757091G>T	ENST00000367545.3	+	9	876	c.876G>T	c.(874-876)gaG>gaT	p.E292D		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	292	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTGAGGAGGAGCATGAGAGTC	0.498													10	29					0.00621372	0.00621372	1	1	0	T	144757091	G	T	144757091	3	4	36	1	0	0	0	0	1	0	0	0	17162	962	34	5	910	5	UTRN	6	144757091	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	132635263	144757091	26357976	11	3276										
AHR	196	broad.mit.edu	37	chr7	17362140	17362140	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	catagttgcattaaaatcctCccctactgaaagaaacggag	7	10	0	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:17362140C>T	ENST00000242057.4	+	3	912	c.269C>T	c.(268-270)tCc>tTc	p.S90F		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	90					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TTAAAATCCTCCCCTACTGAA	0.343													6	14					0	0	1	0	0	T	17362140	C	T	17362140	3	4	36	1	0	0	0	0	1	0	0	0	413	855	30	3	279	3	AHR	7	17362140	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		17362140	141776523	12	3277										
HIP1	3092	broad.mit.edu	37	chr7	75187513	75187515	+	In_Frame_Del	DEL	CTT	CTT	-													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ttctgaaccagctcgctgtaCttctcctttagcttgctata							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:75187513_75187515delCTT	ENST00000336926.6	-	15	1446_1448	c.1420_1422delAAG	c.(1420-1422)del	p.K474del	HIP1_ENST00000434438.2_In_Frame_Del_p.K474del	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	474	pDED.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCTCGCTGTACTTCTCCTTTAGC	0.552			T	PDGFRB	CMML								35	42	---	---	---	---						-	75187515	CTT	-	75187513	7	5	36	1	0	1	0	1	0	0	0	0	7154	564	20	0	1759	0	HIP1	7	75187513	In_Frame_Del	DEL	CTT	TCGA-N9-A4Q4-01A-11D-A28R-08	57825373	75187513	83951150	13	3278										
MYL10	93408	broad.mit.edu	37	chr7	101265461	101265461	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	accatggcctccagttcctcGttcttgacattgatgcggcc	9	14	1	2	rs140607004		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:101265461G>T	ENST00000223167.4	-	5	546	c.369C>A	c.(367-369)aaC>aaA	p.N123K		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	123						mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						CCAGTTCCTCGTTCTTGACAT	0.597													33	41					4.74835e-14	5.38147e-14	1	1	0	T	101265461	G	T	101265461	3	4	36	1	0	0	0	0	1	0	0	0	10091	1136	40	5	327	5	MYL10	7	101265461	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	26077948	101265461	57873202	14	3279										
MGAM	8972	broad.mit.edu	37	chr7	141708409	141708409	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	aggacaacgggtcccccagaTcctggaacaactggtaccac	10	14	0	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:141708409T>A	ENST00000475668.2	+	3	285	c.231T>A	c.(229-231)gaT>gaA	p.D77E	MGAM_ENST00000549489.2_Missense_Mutation_p.D77E			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	77	Ser/Thr-rich.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTCCCCCAGATCCTGGAACAA	0.512													25	31					0	0	1	0	0	A	141708409	T	A	141708409	3	1	36	1	0	0	0	0	1	0	0	0	9590	1432	50	4	237	4	MGAM	7	141708409	Missense_Mutation	SNP	T	TCGA-N9-A4Q4-01A-11D-A28R-08	40442948	141708409	17430254	15	3280										
TAS2R41	259287	broad.mit.edu	37	chr7	143175364	143175364	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ccagggtgggtgccctggctCctgttgggctctgtcctgat	15	12	1	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr7:143175364C>G	ENST00000408916.1	+	1	399	c.399C>G	c.(397-399)ctC>ctG	p.L133L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	133					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TGCCCTGGCTCCTGTTGGGCT	0.478													14	56					0	0	1	0	0	G	143175364	C	G	143175364	2	3	36	1	0	0	0	0	0	0	0	1	15635	842	30	2		2	TAS2R41	7	143175364	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	1466955	143175364	15963299	16	3281										
LRRC6	23639	broad.mit.edu	37	chr8	133637655	133637655	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	aatttctttgtgttgtgttcCtctgtgtctggtgcctgtag	11	7	3	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr8:133637655C>G	ENST00000519595.1	-	6	797	c.699G>C	c.(697-699)gaG>gaC	p.E233D	LRRC6_ENST00000518642.1_Missense_Mutation_p.E233D|LRRC6_ENST00000520446.1_5'UTR|LRRC6_ENST00000250173.1_Missense_Mutation_p.E233D			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	233						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGTTGTGTTCCTCTGTGTCTG	0.388													4	20					0	0	1	0	0	G	133637655	C	G	133637655	3	3	36	1	0	0	0	0	1	0	0	0	9060	680	24	5	729	5	LRRC6	8	133637655	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		133637655	12726367	17	3282										
SCRIB	23513	broad.mit.edu	37	chr8	144885555	144885555	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cggggcgggatcgctaacctCcagggctgcgtcggtgctgg	18	12	0	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr8:144885555C>A	ENST00000356994.2	-	24	3607	c.3601G>T	c.(3601-3603)Gag>Tag	p.E1201*	SCRIB_ENST00000377533.3_Nonsense_Mutation_p.E1120*|SCRIB_ENST00000320476.3_Nonsense_Mutation_p.E1201*	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	1201	Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TCGCTAACCTCCAGGGCTGCG	0.711													5	29					0.000602214	0.000611203	1	1	0	A	144885555	C	A	144885555	4	1	36	1	0	0	0	0	0	1	0	0	13990	864	30	2	1422	2	SCRIB	8	144885555	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	11247900	144885555	1478467	18	3283										
IFNA16	3449	broad.mit.edu	37	chr9	21217162	21217162	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ccttcaggcaggagaaatgaGagattcttcccatttgtgcc	10	10	2	3			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:21217162G>C	ENST00000380216.1	-	1	148	c.143C>G	c.(142-144)tCt>tGt	p.S48C		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	48					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GGAGAAATGAGAGATTCTTCC	0.502													67	41					0	0	1	0	0	C	21217162	G	C	21217162	3	2	36	1	0	0	0	0	1	0	0	0	7578	942	33	2	430	2	IFNA16	9	21217162	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08		21217162	119996269	19	3284										
DENND1A	57706	broad.mit.edu	37	chr9	126143973	126143973	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ttgagcgggccaggggcaacGttcggatcctcgacggggca	17	11	0	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:126143973G>A	ENST00000373624.2	-	22	2969	c.2768C>T	c.(2767-2769)aCg>aTg	p.T923M	DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394219.3_Missense_Mutation_p.T934M|DENND1A_ENST00000542603.1_Missense_Mutation_p.T708M	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	923	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CAGGGGCAACGTTCGGATCCT	0.687													2	1					0	0	1	0	0	A	126143973	G	A	126143973	3	1	36	1	0	0	0	0	1	0	0	0	4454	1145	40	1	265	1	DENND1A	9	126143973	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	104926811	126143973	15069458	20	3285										
INPP5E	56623	broad.mit.edu	37	chr9	139327477	139327487	+	Frame_Shift_Del	DEL	TGGTCTTGATC	TGGTCTTGATC	-													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gctgatgcccaaggccccctTggtcttgatctgagacacga							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:139327477_139327487delTGGTCTTGATC	ENST00000371712.3	-	5	1602_1612	c.1200_1210delGATCAAGACCA	c.(1198-1212)caagfs	p.QIKTK400fs		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	400						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	p.Q400H(1)		NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		AAGGCCCCCTTGGTCTTGATCTGAGACACGA	0.611													11	30	---	---	---	---						-	139327487	TGGTCTTGATC	-	139327477	7	5	36	1	0	1	0	1	0	0	0	0	7800	1821	63	0	748	0	INPP5E	9	139327477	Frame_Shift_Del	DEL	TGGTCTTGATC	TCGA-N9-A4Q4-01A-11D-A28R-08	13183504	139327477	1885954	21	3286										
INPP5E	56623	broad.mit.edu	37	chr9	139333399	139333399	+	Frame_Shift_Del	DEL	C	C	-													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ccaccccagagagagggttaCcccccgaggacgggctccct							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:139333399delC	ENST00000371712.3	-	1	875	c.473delG	c.(472-474)gtfs	p.G158fs		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	158	13 X 4 AA repeats of P-X-X-P.					cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GAGAGGGTTACCCCCCGAGGA	0.721													2	4	---	---	---	---						-	139333399	C	-	139333399	7	5	36	1	0	1	0	1	0	0	0	0	7800	507	18	0	1501	0	INPP5E	9	139333399	Frame_Shift_Del	DEL	C	TCGA-N9-A4Q4-01A-11D-A28R-08	5922	139333399	1880032	22	3287										
NOTCH1	4851	broad.mit.edu	37	chr9	139412690	139412690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cagggttggtgtcgcagttgGagccctcgttacaggggttg	17	8	0	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr9:139412690G>A	ENST00000277541.6	-	7	1229	c.1154C>T	c.(1153-1155)tCc>tTc	p.S385F		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	385	EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCGCAGTTGGAGCCCTCGTT	0.672			"T, Mis, O"	TRB@	T-ALL					HNSCC(8;0.001)			5	18					0	0	1	0	0	A	139412690	G	A	139412690	3	1	36	1	0	0	0	0	1	0	0	0	10593	1174	41	3	6625	3	NOTCH1	9	139412690	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	79291	139412690	1800741	23	3288										
SVIL	6840	broad.mit.edu	37	chr10	29747234	29747234	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tccaggcgggcagggcgttgTattcatccctcgtcatgtct	12	12	3	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr10:29747234T>C	ENST00000375398.2	-	40	7036	c.6587A>G	c.(6586-6588)tAc>tGc	p.Y2196C	PTCHD3P1_ENST00000455774.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|PTCHD3P1_ENST00000446807.1_RNA|PTCHD3P1_ENST00000445521.1_RNA|PTCHD3P1_ENST00000423223.1_RNA|PTCHD3P1_ENST00000438202.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|SVIL_ENST00000535393.1_Missense_Mutation_p.Y1110C|SVIL_ENST00000375400.3_Missense_Mutation_p.Y1770C|SVIL_ENST00000355867.4_Missense_Mutation_p.Y2196C|PTCHD3P1_ENST00000430295.1_RNA			O95425	SVIL_HUMAN	supervillin	2196	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CAGGGCGTTGTATTCATCCCT	0.572													20	65					0	0	1	0	0	C	29747234	T	C	29747234	3	2	36	1	0	0	0	0	1	0	0	0	15476	1638	57	4	61	4	SVIL	10	29747234	Missense_Mutation	SNP	T	TCGA-N9-A4Q4-01A-11D-A28R-08		29747234	105787513	24	3289										
MKI67	4288	broad.mit.edu	37	chr10	129901213	129901213	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cgggttctactttaggggccCgaagaactcttctggatatt	11	9	3	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr10:129901213C>T	ENST00000368654.3	-	13	9266	c.8891G>A	c.(8890-8892)cGg>cAg	p.R2964Q	MKI67_ENST00000368653.3_Missense_Mutation_p.R2604Q	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2964					cell proliferation	nucleolus	ATP binding|protein C-terminus binding	p.R2964P(1)		NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTAGGGGCCCGAAGAACTCT	0.493													4	110					0	0	1	0	0	T	129901213	C	T	129901213	3	4	36	1	0	0	0	0	1	0	0	0	9645	652	23	1	891	1	MKI67	10	129901213	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	100153979	129901213	5633534	25	3290										
OR5T1	390155	broad.mit.edu	37	chr11	56043798	56043798	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	actatcctgattgtcctgatCtcctatggttttattctgtt	6	9	2	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr11:56043798C>A	ENST00000313033.2	+	1	770	c.684C>A	c.(682-684)atC>atA	p.I228I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TTGTCCTGATCTCCTATGGTT	0.433													37	152					1.21669e-08	1.33444e-08	1	1	0	A	56043798	C	A	56043798	2	1	36	1	0	0	0	0	0	0	0	1	11227	903	32	2		2	OR5T1	11	56043798	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		56043798	78962718	26	3291										
MYO7A	4647	broad.mit.edu	37	chr11	76883793	76883793	+	Splice_Site	DEL	G	G	-													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cgctgccgtccgtccccccaGggcgccgagaccaggaagcg							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr11:76883793delG	ENST00000409709.3	+	16	2069		c.e16-1		MYO7A_ENST00000458637.2_Splice_Site|MYO7A_ENST00000409893.1_Splice_Site|MYO7A_ENST00000409619.2_Splice_Site	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA						actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CGTCCCCCCAGGGCGCCGAGA	0.687													2	4	---	---	---	---						-	76883793	G	-	76883793	8	5	36	1	0	1	0	1	0	0	1	0	10129	1014	35	0	1855	0	MYO7A	11	76883793	Splice_Site	DEL	G	TCGA-N9-A4Q4-01A-11D-A28R-08	20839995	76883793	58122723	27	3292										
CD163L1	283316	broad.mit.edu	37	chr12	7550963	7550963	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tcatttccaatgcaagaaacGtcatccagccaaataggtcc	6	12	2	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr12:7550963G>T	ENST00000313599.3	-	7	1683	c.1626C>A	c.(1624-1626)gaC>gaA	p.D542E	CD163L1_ENST00000416109.2_Missense_Mutation_p.D552E|CD163L1_ENST00000396630.1_Missense_Mutation_p.D542E			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	542	SRCR 5.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TGCAAGAAACGTCATCCAGCC	0.413													48	66					4.18559e-23	5.17491e-23	1	1	0	T	7550963	G	T	7550963	3	4	36	1	0	0	0	0	1	0	0	0	2990	1136	40	5	2787	5	CD163L1	12	7550963	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08		7550963	126300932	28	3293										
PPFIBP1	8496	broad.mit.edu	37	chr12	27803070	27803070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tgaagataagttcagagacaCagaggtgagtgatacagtct	12	5	2	6			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr12:27803070C>T	ENST00000318304.8	+	7	882	c.599C>T	c.(598-600)aCa>aTa	p.T200I	PPFIBP1_ENST00000228425.6_Missense_Mutation_p.T200I|PPFIBP1_ENST00000542629.1_Missense_Mutation_p.T200I|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.T47I	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	200					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					TTCAGAGACACAGAGGTGAGT	0.428													10	28					0	0	1	0	0	T	27803070	C	T	27803070	3	4	36	1	0	0	0	0	1	0	0	0	12357	478	17	3	659	3	PPFIBP1	12	27803070	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	20252107	27803070	106048825	29	3294										
AKAP13	11214	broad.mit.edu	37	chr15	86225393	86225393	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ctgccttgttttctagattcAcggcccttccacagtacctt	6	14	2	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr15:86225393A>G	ENST00000394518.2	+	15	5201	c.5106A>G	c.(5104-5106)tcA>tcG	p.S1702S	AKAP13_ENST00000361243.2_Silent_p.S1706S|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000394510.2_5'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1702					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TTCTAGATTCACGGCCCTTCC	0.338													11	48					0	0	1	0	0	G	86225393	A	G	86225393	2	3	36	1	0	0	0	0	0	0	0	1	446	146	6	4		4	AKAP13	15	86225393	Silent	SNP	A	TCGA-N9-A4Q4-01A-11D-A28R-08		86225393	16305999	30	3295										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1814128	1814128	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ccctgcagctgagtcccaacGggggccaggaggacacgcgg	16	14	0	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:1814128G>C	ENST00000250894.4	+	18	2192	c.2035G>C	c.(2035-2037)Ggg>Cgg	p.G679R	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.G673R	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	679					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding	p.G679W(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						GAGTCCCAACGGGGGCCAGGA	0.662													15	19					0	0	1	0	0	C	1814128	G	C	1814128	3	2	36	1	0	0	0	0	1	0	0	0	9335	1116	39	5	2121	5	MAPK8IP3	16	1814128	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08		1814128	88540625	31	3296										
USP7	7874	broad.mit.edu	37	chr16	8999095	8999106	+	In_Frame_Del	DEL	GAACAGACAGGT	GAACAGACAGGT	-													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gtaagcattagtgcagtgtcGaacagacaggtcgtcatcgt					rs146945749		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:8999095_8999106delGAACAGACAGGT	ENST00000344836.4	-	14	1709_1720	c.1511_1522delACCTGTCTGTTC	c.(1510-1524)gga>g	p.DLSVR504del	USP7_ENST00000381886.4_In_Frame_Del_p.DLSVR488del|USP7_ENST00000535863.1_In_Frame_Del_p.DLSVR405del	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	504					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GTGCAGTGTCGAACAGACAGGTCGTCATCGTG	0.434											OREG0023595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	32	---	---	---	---						-	8999106	GAACAGACAGGT	-	8999095	7	5	36	1	0	1	0	1	0	0	0	0	17147	1066	37	0	1858	0	USP7	16	8999095	In_Frame_Del	DEL	GAACAGACAGGT	TCGA-N9-A4Q4-01A-11D-A28R-08	7184967	8999095	81355658	32	3297										
MKL2	57496	broad.mit.edu	37	chr16	14341273	14341273	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tcagccccaggctttactgaCcacgcagactgctcagctgc	9	16	2	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:14341273C>T	ENST00000571589.1	+	12	2328	c.2156C>T	c.(2155-2157)aCc>aTc	p.T719I	MKL2_ENST00000341243.5_Missense_Mutation_p.T708I|MKL2_ENST00000574045.1_Intron|MKL2_ENST00000318282.5_Intron	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	708	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTTTACTGACCACGCAGACT	0.592													19	11					0	0	1	0	0	T	14341273	C	T	14341273	3	4	36	1	0	0	0	0	1	0	0	0	9649	522	18	3		3	MKL2	16	14341273	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	5342178	14341273	76013480	33	3298										
SPIRE2	84501	broad.mit.edu	37	chr16	89922030	89922030	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ggatggggacatcccgccccGggtgaagaaggacgctcacg	16	12	1	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr16:89922030G>A	ENST00000378247.3	+	6	957	c.914G>A	c.(913-915)cGg>cAg	p.R305Q	SPIRE2_ENST00000393062.2_Missense_Mutation_p.R305Q	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	305					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		ATCCCGCCCCGGGTGAAGAAG	0.672													27	15					0	0	1	0	0	A	89922030	G	A	89922030	3	1	36	1	0	0	0	0	1	0	0	0	15127	1116	39	1	936	1	SPIRE2	16	89922030	Missense_Mutation	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	75580757	89922030	432723	34	3299										
TP53	7157	broad.mit.edu	37	chr17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cttcctctgtgcgccggtctCtcccaggacaggcacaaaca	9	16	2	0	rs121912660		TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000359597.4_Missense_Mutation_p.R280T|TP53_ENST00000269305.4_Missense_Mutation_p.R280T|TP53_ENST00000445888.2_Missense_Mutation_p.R280T|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	5					0	0	1	0	0	G	7577099	C	G	7577099	3	3	36	1	0	0	0	0	1	0	0	0	16441	913	32	2	447	2	TP53	17	7577099	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		7577099	73618111	35	3300										
HDAC5	10014	broad.mit.edu	37	chr17	42171102	42171102	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cgcagtgtggggtccacagaGcccaccagagccccccgtag	13	16	0	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr17:42171102G>A	ENST00000225983.6	-	4	521	c.198C>T	c.(196-198)ggC>ggT	p.G66G	HDAC5_ENST00000336057.5_Silent_p.G65G|HDAC5_ENST00000393622.2_Silent_p.G65G|HDAC5_ENST00000586802.1_Silent_p.G65G			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	65					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		GGTCCACAGAGCCCACCAGAG	0.667													7	1					0	0	1	0	0	A	42171102	G	A	42171102	2	1	36	1	0	0	0	0	0	0	0	1	7050	958	34	3		3	HDAC5	17	42171102	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	34594003	42171102	39024108	36	3301										
ATP8B3	148229	broad.mit.edu	37	chr19	1802551	1802551	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tgcagcctcggaggaggaggTtgccaatgtccagggagtat	16	8	0	0	rs142875994	by1000genomes	TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:1802551T>A	ENST00000539485.1	-	11	1231	c.998A>T	c.(997-999)aAc>aTc	p.N333I	ATP8B3_ENST00000526092.1_Missense_Mutation_p.N280I|ATP8B3_ENST00000310127.6_Missense_Mutation_p.N333I|ATP8B3_ENST00000525591.1_Missense_Mutation_p.N280I			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	333					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGAGGAGGTTGCCAATGTC	0.572													11	21					0	0	1	0	0	A	1802551	T	A	1802551	3	1	36	1	0	0	0	0	1	0	0	0	1194	1725	60	4	3028	4	ATP8B3	19	1802551	Missense_Mutation	SNP	T	TCGA-N9-A4Q4-01A-11D-A28R-08		1802551	57326432	37	3302			1	5		3	2	64	N	T_C	9.97148e-05
ATP8B3	148229	broad.mit.edu	37	chr19	1802613	1802613	+	Silent	SNP	C	C	A													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	caccccacgaagtggtgcatCcgactgttaggcgcctcaca							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:1802613C>A	ENST00000539485.1	-	11	1169	c.936G>T	c.(934-936)cgG>cgT	p.R312R	ATP8B3_ENST00000526092.1_Silent_p.R259R|ATP8B3_ENST00000310127.6_Silent_p.R312R|ATP8B3_ENST00000525591.1_Silent_p.R259R			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	312					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGGTGCATCCGACTGTTAG	0.607													5	5					0.000602214	0.000611203	1	1	0	A	1802613	C	A	1802613	2	1	36	1	0	0	0	0	0	0	0	1	1194	842	30	2		2	ATP8B3	19	1802613	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	62	1802613	57326370	38	3303	14	2	1	5		3	2	64	N	T_C	9.97148e-05
ATP8B3	148229	broad.mit.edu	37	chr19	1802614	1802614	+	Missense_Mutation	SNP	C	C	A													0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	accccacgaagtggtgcatcCgactgttaggcgcctcacac							TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:1802614C>A	ENST00000539485.1	-	11	1168	c.935G>T	c.(934-936)cGg>cTg	p.R312L	ATP8B3_ENST00000526092.1_Missense_Mutation_p.R259L|ATP8B3_ENST00000310127.6_Missense_Mutation_p.R312L|ATP8B3_ENST00000525591.1_Missense_Mutation_p.R259L			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	312					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTGCATCCGACTGTTAGG	0.612													5	5					0.000602214	0.000611203	1	1	0	A	1802614	C	A	1802614	3	1	36	1	0	0	0	0	1	0	0	0	1194	652	23	5	3091	5	ATP8B3	19	1802614	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	1	1802614	57326369	39	3304	14	2	1	5		3	2	64	N	T_C	9.97148e-05
LRRC8E	80131	broad.mit.edu	37	chr19	7964528	7964528	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gcacctcatcgatcagtacgActccctctactccaagcgct	6	17	3	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:7964528A>C	ENST00000306708.6	+	3	1222	c.1121A>C	c.(1120-1122)gAc>gCc	p.D374A	AC010336.1_ENST00000539278.1_3'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	374						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						GATCAGTACGACTCCCTCTAC	0.567													36	1					0	0	1	0	0	C	7964528	A	C	7964528	3	2	36	1	0	0	0	0	1	0	0	0	9069	275	10	4	1127	4	LRRC8E	19	7964528	Missense_Mutation	SNP	A	TCGA-N9-A4Q4-01A-11D-A28R-08	6161914	7964528	51164455	40	3305										
ZNF780B	163131	broad.mit.edu	37	chr19	40541792	40541792	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gtttctcgccagtatgaattCggcaatgttcaatgagttgg	11	7	2	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:40541792C>T	ENST00000434248.1	-	5	1039	c.974G>A	c.(973-975)cGa>cAa	p.R325Q	ZNF780B_ENST00000221355.6_Missense_Mutation_p.R177Q	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGTATGAATTCGGCAATGTTC	0.388													27	80					0	0	1	0	0	T	40541792	C	T	40541792	3	4	36	1	0	0	0	0	1	0	0	0	18201	884	31	1	1531	1	ZNF780B	19	40541792	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	32577264	40541792	18587191	41	3306										
GRIK5	2901	broad.mit.edu	37	chr19	42509903	42509903	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	atgccaatgccgtagcccttGgtgtcgaggagtcccccgat	12	13	0	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:42509903G>T	ENST00000262895.3	-	16	2234	c.2235C>A	c.(2233-2235)acC>acA	p.T745T	GRIK5_ENST00000301218.4_Silent_p.T745T|GRIK5_ENST00000593562.1_Silent_p.T745T	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	745						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CGTAGCCCTTGGTGTCGAGGA	0.627													17	29					3.99206e-14	4.60102e-14	1	1	0	T	42509903	G	T	42509903	2	4	36	1	0	0	0	0	0	0	0	1	6817	1335	47	5		5	GRIK5	19	42509903	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	1968111	42509903	16619080	42	3307										
KIR3DL2	3812	broad.mit.edu	37	chr19	55363703	55363703	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	cactccctcactgggtggtcGgcacccagcaaccccctggt	10	18	1	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr19:55363703G>A	ENST00000326321.3	+	3	354	c.321G>A	c.(319-321)tcG>tcA	p.S107S	KIR3DL2_ENST00000270442.5_Silent_p.S107S|KIR3DL1_ENST00000402254.2_Intron	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	107					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		CTGGGTGGTCGGCACCCAGCA	0.597													81	3					0	0	1	0	0	A	55363703	G	A	55363703	2	1	36	1	0	0	0	0	0	0	0	1	8363	1103	39	1		1	KIR3DL2	19	55363703	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	12853800	55363703	3765280	43	3308										
GATSL3	652968	broad.mit.edu	37	chr22	30682353	30682353	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	tcaggactgctagaggctgcCtccttgggggtgctggggag	18	9	1	1			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chr22:30682353C>T	ENST00000407689.3	-	6	771	c.642G>A	c.(640-642)gaG>gaA	p.E214E	GATSL3_ENST00000404953.3_Intron|RP1-130H16.18_ENST00000447976.1_3'UTR|GATSL3_ENST00000459785.1_Intron	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						TAGAGGCTGCCTCCTTGGGGG	0.572													34	2					0	0	1	0	0	T	30682353	C	T	30682353	2	4	36	1	0	0	0	0	0	0	0	1	6304	680	24	3		3	GATSL3	22	30682353	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		30682353	20622213	44	3309										
NLGN4X	57502	broad.mit.edu	37	chrX	5821878	5821878	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ccagctggacagggcggtgcCgctctgaatgatggccttct	14	12	2	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:5821878C>T	ENST00000381095.3	-	5	1468	c.841G>A	c.(841-843)Ggc>Agc	p.G281S	NLGN4X_ENST00000538097.1_Missense_Mutation_p.G281S|NLGN4X_ENST00000381092.1_Missense_Mutation_p.G281S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.G281S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.G301S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	281					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AGGGCGGTGCCGCTCTGAATG	0.532													12	73					0	0	1	0	0	T	5821878	C	T	5821878	3	4	36	1	0	0	0	0	1	0	0	0	10510	652	23	1	1617	1	NLGN4X	23	5821878	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08		5821878	149448682	45	3310										
FRMPD4	9758	broad.mit.edu	37	chrX	12735885	12735885	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	aggccagcaaccgacctcccGcccaaagttgtgccttccaa	8	17	0	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:12735885G>A	ENST00000380682.1	+	16	3446	c.2940G>A	c.(2938-2940)ccG>ccA	p.P980P		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	980					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCGACCTCCCGCCCAAAGTTG	0.572													106	50					0	0	1	0	0	A	12735885	G	A	12735885	2	1	36	1	0	0	0	0	0	0	0	1	6093	1074	38	1		1	FRMPD4	23	12735885	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	6914007	12735885	142534675	46	3311										
WDR13	64743	broad.mit.edu	37	chrX	48458032	48458032	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gcaagtcgggccatggccggGgacacgtcactgagcgagaa	16	11	1	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:48458032G>A	ENST00000218056.5	+	4	955	c.450G>A	c.(448-450)ggG>ggA	p.G150G	WDR13_ENST00000492715.1_3'UTR	NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	150						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						CCATGGCCGGGGACACGTCAC	0.617													23	52					0	0	1	0	0	A	48458032	G	A	48458032	2	1	36	1	0	0	0	0	0	0	0	1	17334	1219	43	3		3	WDR13	23	48458032	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	35722147	48458032	106812528	47	3312										
LPAR4	2846	broad.mit.edu	37	chrX	78010756	78010756	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gggagcatgctctttctcacCtgtattagtgtggatcgttt	11	8	2	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:78010756C>A	ENST00000435339.2	+	2	795	c.390C>A	c.(388-390)acC>acA	p.T130T	LPAR4_ENST00000373301.2_Silent_p.T130T	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	130						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TCTTTCTCACCTGTATTAGTG	0.468													60	50					9.59835e-30	1.20868e-29	1	1	0	A	78010756	C	A	78010756	2	1	36	1	0	0	0	0	0	0	0	1	8951	668	24	5		5	LPAR4	23	78010756	Silent	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	29552724	78010756	77259804	48	3313										
SOX3	6658	broad.mit.edu	37	chrX	139586343	139586343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	gcggtgcatcggcggcagcgCgggcggcggcggcgggctgc	23	13	0	0			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:139586343C>T	ENST00000370536.2	-	1	882	c.883G>A	c.(883-885)Gcg>Acg	p.A295T		NM_005634.2	NP_005625.2	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	295					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	10	Acute lymphoblastic leukemia(192;7.65e-05)					ggcggcagcgcgggcggcggc	0.726													5	5					0	0	1	0	0	T	139586343	C	T	139586343	3	4	36	1	0	0	0	0	1	0	0	0	15004	768	27	1	461	1	SOX3	23	139586343	Missense_Mutation	SNP	C	TCGA-N9-A4Q4-01A-11D-A28R-08	61575587	139586343	15684217	49	3314										
PNMA3	29944	broad.mit.edu	37	chrX	152226402	152226402	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0408163265306122	2	1	0.82190635451505	3.78076923076923	0	0.428571428571429	1	0	ctggccctggtgaagctcctGcgtgaggaggaggaatggga	18	8	0	2			TCGA-N9-A4Q4-01A-11D-A28R-08	TCGA-N9-A4Q4-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c706ee71-26f2-43c9-aa9a-22bf9a393d89	3cb2acb2-e4c6-46de-a515-ee7d5d8a472c	g.chrX:152226402G>T	ENST00000447306.1	+	2	1326	c.990G>T	c.(988-990)ctG>ctT	p.L330L	PNMA3_ENST00000370264.4_Silent_p.L330L|PNMA3_ENST00000370265.4_Silent_p.L330L	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	330					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					tgaagctcctgcgtgaggagg	0.572													14	55					1.5842e-08	1.70993e-08	1	1	0	T	152226402	G	T	152226402	2	4	36	1	0	0	0	0	0	0	0	1	12202	1306	46	5		5	PNMA3	23	152226402	Silent	SNP	G	TCGA-N9-A4Q4-01A-11D-A28R-08	12640059	152226402	3044158	50	3315										
SDF4	51150	broad.mit.edu	37	chr1	1152961	1152961	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtgaagaactcgctgtacttGagcacctcctcgggctccag	11	13	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:1152961G>C	ENST00000360001.6	-	7	1282	c.1020C>G	c.(1018-1020)ctC>ctG	p.L340L	SDF4_ENST00000263741.7_3'UTR			Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	340	EF-hand 6.|Necessary for intracellular retention in Golgi apparatus lumen (By similarity).				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CGCTGTACTTGAGCACCTCCT	0.662													9	60					0	0	1	0	0	C	1152961	G	C	1152961	2	2	37	1	0	0	0	0	0	0	0	1	14015	1277	45	2		2	SDF4	1	1152961	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		1152961	248097660	1	3316										
PTCHD2	57540	broad.mit.edu	37	chr1	11589956	11589956	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggggccatggtctttgtggtCttcggcattattggcgtcaa	14	8	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:11589956C>G	ENST00000294484.6	+	15	3180	c.3042C>G	c.(3040-3042)gtC>gtG	p.V1014V	PTCHD2_ENST00000389575.3_Silent_p.V1014V	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1014					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCTTTGTGGTCTTCGGCATTA	0.647													10	85					0	0	1	0	0	G	11589956	C	G	11589956	2	3	37	1	0	0	0	0	0	0	0	1	12781	900	32	2		2	PTCHD2	1	11589956	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10436995	11589956	237660665	2	3317										
VPS13D	55187	broad.mit.edu	37	chr1	12401942	12401942	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctgaccaccacacccaccaGgtaagcagtcagtttatatt	6	14	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:12401942G>C	ENST00000358136.3	+	41	8862	c.8732_splice	c.e41+1	p.R2911_splice	VPS13D_ENST00000356315.4_Splice_Site_p.R2886_splice	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2910					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACACCCACCAGGTAAGCAGTC	0.577													11	88					0	0	1	0	0	C	12401942	G	C	12401942	5	2	37	1	0	0	0	0	0	0	1	0	17251	1014	35	5	8890	5	VPS13D	1	12401942	Splice_Site	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	811986	12401942	236848679	3	3318										
YARS	8565	broad.mit.edu	37	chr1	33245077	33245077	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acacgtgctcaccaggagcaGagcctgccggagggtccaga	14	13	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:33245077G>C	ENST00000373477.4	-	12	2290	c.1382C>G	c.(1381-1383)tCt>tGt	p.S461C	YARS_ENST00000469100.1_5'UTR	NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	461	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	ACCAGGAGCAGAGCCTGCCGG	0.527													8	66					0	0	1	0	0	C	33245077	G	C	33245077	3	2	37	1	0	0	0	0	1	0	0	0	17526	942	33	2	212	2	YARS	1	33245077	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	20843135	33245077	216005544	4	3319										
TFAP2E	339488	broad.mit.edu	37	chr1	36060202	36060202	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcactcaaggggctggacaaGatgtttctaagcagtgtggg	14	7	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:36060202G>C	ENST00000373235.3	+	7	1462	c.1254G>C	c.(1252-1254)aaG>aaC	p.K418N		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	418						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGCTGGACAAGATGTTTCTAA	0.542													16	128					0	0	1	0	0	C	36060202	G	C	36060202	3	2	37	1	0	0	0	0	1	0	0	0	15850	933	33	2	1280	2	TFAP2E	1	36060202	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2815125	36060202	213190419	5	3320										
MACF1	23499	broad.mit.edu	37	chr1	39919466	39919466	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcctggctgtctgccaccccGattgcatcacaaccatcaaa	6	16	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:39919466G>A	ENST00000564288.1	+	88	21607	c.20830G>A	c.(20830-20832)Gat>Aat	p.D6944N	MACF1_ENST00000539005.1_Missense_Mutation_p.D4755N|MACF1_ENST00000361689.2_Missense_Mutation_p.D4885N|MACF1_ENST00000289893.4_Missense_Mutation_p.D5387N|MACF1_ENST00000317713.7_Missense_Mutation_p.D4885N|MACF1_ENST00000545844.1_Missense_Mutation_p.D4885N|MACF1_ENST00000372915.3_Missense_Mutation_p.D6843N|MACF1_ENST00000567887.1_Missense_Mutation_p.D6981N			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6843					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGCCACCCCGATTGCATCAC	0.498													93	194					0	0	1	0	0	A	39919466	G	A	39919466	3	1	37	1	0	0	0	0	1	0	0	0	9189	1058	37	1	21138	1	MACF1	1	39919466	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	3859264	39919466	209331155	6	3321										
HIVEP3	59269	broad.mit.edu	37	chr1	42049679	42049679	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccagggatccgctccatctCcagcccatgtgggtacatct	9	16	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:42049679C>G	ENST00000372584.1	-	3	1804	c.790G>C	c.(790-792)Gag>Cag	p.E264Q	HIVEP3_ENST00000247584.5_Missense_Mutation_p.E264Q|HIVEP3_ENST00000429157.2_Missense_Mutation_p.E264Q|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E264Q	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	264	Acidic 1.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CGCTCCATCTCCAGCCCATGT	0.572													9	76					0	0	1	0	0	G	42049679	C	G	42049679	3	3	37	1	0	0	0	0	1	0	0	0	7228	864	30	2	6454	2	HIVEP3	1	42049679	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2130213	42049679	207200942	7	3322										
IPO13	9670	broad.mit.edu	37	chr1	44426880	44426880	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agcctgcccactttcccccaAttgaggccctcttcctgctc	6	19	1	1	rs117692141		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:44426880A>G	ENST00000372343.3	+	14	2952	c.2290A>G	c.(2290-2292)Att>Gtt	p.I764V		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	764					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTTTCCCCCAATTGAGGCCCT	0.587													37	358					0	0	1	0	0	G	44426880	A	G	44426880	3	3	37	1	0	0	0	0	1	0	0	0	7837	101	4	4	2344	4	IPO13	1	44426880	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	2377201	44426880	204823741	8	3323										
ZSWIM5	57643	broad.mit.edu	37	chr1	45553866	45553867	+	Frame_Shift_Del	DEL	AG	AG	-													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttataagtcactgctggttcAgaggcagtggccagctcagt							TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:45553866_45553867delAG	ENST00000359600.5	-	2	843_844	c.638_639delCT	c.(637-639)tfs	p.S213fs	ZSWIM5_ENST00000464588.1_5'UTR	NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	213							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					CTGCTGGTTCAGAGGCAGTGGC	0.421													7	61	---	---	---	---						-	45553867	AG	-	45553866	7	5	37	1	0	1	0	1	0	0	0	0	18283	175	7	0	2970	0	ZSWIM5	1	45553866	Frame_Shift_Del	DEL	AG	TCGA-N9-A4Q7-01A-11D-A28R-08	1126986	45553866	203696755	9	3324										
DHCR24	1718	broad.mit.edu	37	chr1	55349324	55349324	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tccacttccagaatgtccatCaggttgatcatgatgttttt	7	9	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:55349324C>G	ENST00000371269.3	-	2	452	c.354G>C	c.(352-354)ctG>ctC	p.L118L	DHCR24_ENST00000535035.1_Silent_p.L77L	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	118	FAD-binding PCMH-type.				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						GAATGTCCATCAGGTTGATCA	0.537													26	211					0	0	1	0	0	G	55349324	C	G	55349324	2	3	37	1	0	0	0	0	0	0	0	1	4504	813	29	2		2	DHCR24	1	55349324	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	9795458	55349324	193901297	10	3325										
MYSM1	114803	broad.mit.edu	37	chr1	59132892	59132892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	actgttacatggttctgctgCacagacctataaacgattga	8	9	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:59132892C>T	ENST00000472487.1	-	16	1888	c.1849G>A	c.(1849-1851)Gca>Aca	p.A617T	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	617	MPN.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					GGTTCTGCTGCACAGACCTAT	0.378													5	35					0	0	1	0	0	T	59132892	C	T	59132892	3	4	37	1	0	0	0	0	1	0	0	0	10148	710	25	3	657	3	MYSM1	1	59132892	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3783568	59132892	190117729	11	3326										
IFI44	10561	broad.mit.edu	37	chr1	79116090	79116090	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatgcagaagagagttaccaGgaaggaaagtatgcttccat	11	6	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:79116090G>C	ENST00000370747.4	+	2	295	c.210G>C	c.(208-210)caG>caC	p.Q70H	IFI44_ENST00000495254.1_Intron|IFI44_ENST00000545124.1_Intron	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	70					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						AGAGTTACCAGGAAGGAAAGT	0.368													11	102					0	0	1	0	0	C	79116090	G	C	79116090	3	2	37	1	0	0	0	0	1	0	0	0	7560	991	35	5	212	5	IFI44	1	79116090	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	19983198	79116090	170134531	12	3327										
GNG5	2787	broad.mit.edu	37	chr1	84967543	84967543	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttttactacaaaaaggaacaGactttctggggtctgaaggg	11	6	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:84967543G>C	ENST00000370641.3	-	2	665	c.192C>G	c.(190-192)gtC>gtG	p.V64V	GNG5_ENST00000370645.4_Silent_p.V64V|GNG5_ENST00000487806.1_5'UTR			P63218	GBG5_HUMAN	guanine nucleotide binding protein (G protein), gamma 5	64					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)|skin(1)	2				all cancers(265;0.00634)|Epithelial(280;0.0175)|OV - Ovarian serous cystadenocarcinoma(397;0.159)		AAAAGGAACAGACTTTCTGGG	0.388													6	49					0	0	1	0	0	C	84967543	G	C	84967543	2	2	37	1	0	0	0	0	0	0	0	1	6571	929	33	2		2	GNG5	1	84967543	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	5851453	84967543	164283078	13	3328										
HFM1	164045	broad.mit.edu	37	chr1	91779552	91779552	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gatttatgctaagatcttcaGatttaagagctcttttcaca	6	7	4	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:91779552G>C	ENST00000370425.3	-	29	3304	c.3206C>G	c.(3205-3207)tCt>tGt	p.S1069C	HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000294696.5_Missense_Mutation_p.S301C|HFM1_ENST00000370424.3_Missense_Mutation_p.S748C	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	1069	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AAGATCTTCAGATTTAAGAGC	0.274													5	67					0	0	1	0	0	C	91779552	G	C	91779552	3	2	37	1	0	0	0	0	1	0	0	0	7123	942	33	2	1145	2	HFM1	1	91779552	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6812009	91779552	157471069	14	3329										
GNAI3	2773	broad.mit.edu	37	chr1	110121874	110121874	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctggcagtgctgaagaaggaGtcatgactccagaactagca	12	9	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:110121874G>A	ENST00000369851.4	+	4	462	c.352G>A	c.(352-354)Gtc>Atc	p.V118I		NM_006496.3	NP_006487.1	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	118					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		TGAAGAAGGAGTCATGACTCC	0.443													8	87					0	0	1	0	0	A	110121874	G	A	110121874	3	1	37	1	0	0	0	0	1	0	0	0	6547	1029	36	3	366	3	GNAI3	1	110121874	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	18342322	110121874	139128747	15	3330										
KCNA3	3738	broad.mit.edu	37	chr1	111216487	111216487	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtggctttgctaggacaagcGaagaaccgcaccagcagttc	12	11	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:111216487G>A	ENST00000369769.2	-	1	1168	c.945C>T	c.(943-945)ttC>ttT	p.F315F		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	315						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGGACAAGCGAAGAACCGCA	0.557													24	95					0	0	1	0	0	A	111216487	G	A	111216487	2	1	37	1	0	0	0	0	0	0	0	1	8047	1049	37	1		1	KCNA3	1	111216487	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1094613	111216487	138034134	16	3331										
SPAG17	200162	broad.mit.edu	37	chr1	118629493	118629493	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgctatctcaggctatctgaCctttttctccctctctgaga	6	13	4	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:118629493C>A	ENST00000336338.5	-	11	1563		c.e11+1			NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17							cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GGCTATCTGACCTTTTTCTCC	0.458													33	105					8.16721e-17	8.97155e-17	1	1	0	A	118629493	C	A	118629493	5	1	37	1	0	0	0	0	0	0	1	0	15034	521	18	5	5325	5	SPAG17	1	118629493	Splice_Site	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	7413006	118629493	130621128	17	3332										
JTB	10899	broad.mit.edu	37	chr1	153948312	153948312	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagcactcaccttttgaactCatttctcttagatgagctgc	6	12	3	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:153948312C>T	ENST00000271843.4	-	4	709	c.274G>A	c.(274-276)Gag>Aag	p.E92K	JTB_ENST00000356648.1_Missense_Mutation_p.E63K|JTB_ENST00000368589.1_Missense_Mutation_p.E63K	NM_006694.3	NP_006685.1	O76095	JTB_HUMAN	jumping translocation breakpoint	92					apoptosis|cell cycle cytokinesis|mitosis|positive regulation of protein kinase activity	integral to plasma membrane|membrane fraction|microtubule organizing center|midbody|mitochondrion|spindle	protein kinase binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)	10	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTTTTGAACTCATTTCTCTTA	0.463													6	135					0	0	1	0	0	T	153948312	C	T	153948312	3	4	37	1	0	0	0	0	1	0	0	0	8010	835	29	3	174	3	JTB	1	153948312	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	35318819	153948312	95302309	18	3333										
KIAA0907	22889	broad.mit.edu	37	chr1	155887352	155887352	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctctgtgaatcgtctcttctGtgcctggggctgacttggga	13	10	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:155887352G>C	ENST00000368320.3	-	11	1403	c.1378C>G	c.(1378-1380)Cag>Gag	p.Q460E	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q460E			Q7Z7F0	K0907_HUMAN	KIAA0907	460										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CGTCTCTTCTGTGCCTGGGGC	0.537													18	158					0	0	1	0	0	C	155887352	G	C	155887352	3	2	37	1	0	0	0	0	1	0	0	0	8240	1386	48	5	482	5	KIAA0907	1	155887352	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1939040	155887352	93363269	19	3334										
CCT3	7203	broad.mit.edu	37	chr1	156281931	156281931	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tattcatctccaattttcttGatttccaacaggcctgctcc	4	13	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:156281931G>C	ENST00000295688.3	-	11	1336	c.1056C>G	c.(1054-1056)atC>atG	p.I352M	CCT3_ENST00000368259.2_Missense_Mutation_p.I314M|CCT3_ENST00000368261.3_Missense_Mutation_p.I307M|CCT3_ENST00000472765.2_Missense_Mutation_p.I307M	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	352					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CAATTTTCTTGATTTCCAACA	0.517													6	65					0	0	1	0	0	C	156281931	G	C	156281931	3	2	37	1	0	0	0	0	1	0	0	0	2976	1280	45	2	597	2	CCT3	1	156281931	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	394579	156281931	92968690	20	3335										
OR10K1	391109	broad.mit.edu	37	chr1	158435818	158435818	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgcctgtggcttcactgtctCcctggtcaccacctccctag	8	17	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:158435818C>T	ENST00000289451.2	+	1	547	c.467C>T	c.(466-468)tCc>tTc	p.S156F		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TTCACTGTCTCCCTGGTCACC	0.532													22	203					0	0	1	0	0	T	158435818	C	T	158435818	3	4	37	1	0	0	0	0	1	0	0	0	10960	855	30	3	469	3	OR10K1	1	158435818	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2153887	158435818	90814803	21	3336										
OR10X1	128367	broad.mit.edu	37	chr1	158549080	158549080	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtggttactgtctatacaagAcagcctaataactgccagca	8	10	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:158549080A>G	ENST00000368150.1	-	1	609	c.610T>C	c.(610-612)Tct>Cct	p.S204P		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					TCTATACAAGACAGCCTAATA	0.433													5	70					0	0	1	0	0	G	158549080	A	G	158549080	3	3	37	1	0	0	0	0	1	0	0	0	10969	275	10	4	365	4	OR10X1	1	158549080	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	113262	158549080	90701541	22	3337										
PYHIN1	149628	broad.mit.edu	37	chr1	158909028	158909028	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcagctccacccaacacttcCtcaactgaggtacactcttc	4	17	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:158909028C>T	ENST00000368140.1	+	4	815	c.570C>T	c.(568-570)tcC>tcT	p.S190S	PYHIN1_ENST00000392252.3_Silent_p.S181S|PYHIN1_ENST00000368138.3_Silent_p.S181S|PYHIN1_ENST00000368135.4_Silent_p.S190S|PYHIN1_ENST00000392254.2_Silent_p.S190S	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	190					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					CCAACACTTCCTCAACTGAGG	0.502													7	127					0	0	1	0	0	T	158909028	C	T	158909028	2	4	37	1	0	0	0	0	0	0	0	1	12916	668	24	3		3	PYHIN1	1	158909028	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	359948	158909028	90341593	23	3338										
IFI16	3428	broad.mit.edu	37	chr1	158984677	158984677	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggcaaactaataaaaattttCgaagatataccaacgcttga	6	7	0	2	rs144369567	byFrequency	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:158984677C>T	ENST00000295809.7	+	2	462	c.207C>T	c.(205-207)ttC>ttT	p.F69F	IFI16_ENST00000359709.3_Silent_p.F69F|IFI16_ENST00000368131.4_Silent_p.F69F|IFI16_ENST00000368132.3_Silent_p.F69F|IFI16_ENST00000430894.2_Silent_p.F73F|IFI16_ENST00000340979.6_Silent_p.F69F|IFI16_ENST00000448393.2_Silent_p.F69F			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	69	DAPIN.|Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					TAAAAATTTTCGAAGATATAC	0.388													7	93					0	0	1	0	0	T	158984677	C	T	158984677	2	4	37	1	0	0	0	0	0	0	0	1	7554	883	31	1		1	IFI16	1	158984677	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	75649	158984677	90265944	24	3339										
PAPPA2	60676	broad.mit.edu	37	chr1	176525515	176525515	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	attttggctgggtgggcactCtgttctgccaactctgagct	12	10	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:176525515C>G	ENST00000367662.3	+	2	1221	c.57C>G	c.(55-57)ctC>ctG	p.L19L	PAPPA2_ENST00000367661.3_Silent_p.L19L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	19					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGTGGGCACTCTGTTCTGCCA	0.507													8	161					0	0	1	0	0	G	176525515	C	G	176525515	2	3	37	1	0	0	0	0	0	0	0	1	11479	900	32	2		2	PAPPA2	1	176525515	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	17540838	176525515	72725106	25	3340										
ASTN1	460	broad.mit.edu	37	chr1	176845718	176845718	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggggcatggggtcttcacgaTcacgtcgcttggcctggagc	16	11	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:176845718T>G	ENST00000367654.2	-	21	3455	c.3442A>C	c.(3442-3444)Atc>Ctc	p.I1148L	ASTN1_ENST00000361833.2_Missense_Mutation_p.I1140L|ASTN1_ENST00000424564.2_Missense_Mutation_p.I1140L|ASTN1_ENST00000367657.3_Missense_Mutation_p.I1140L			O14525	ASTN1_HUMAN	astrotactin 1	1148					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GTCTTCACGATCACGTCGCTT	0.582													7	62					0	0	1	0	0	G	176845718	T	G	176845718	3	3	37	1	0	0	0	0	1	0	0	0	1063	1435	50	4	482	4	ASTN1	1	176845718	Missense_Mutation	SNP	T	TCGA-N9-A4Q7-01A-11D-A28R-08	320203	176845718	72404903	26	3341										
ANGPTL1	9068	broad.mit.edu	37	chr1	178834847	178834847	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	taattttgaattgtccacctCtgcaatgtccagtgtccact	6	11	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:178834847C>G	ENST00000234816.2	-	3	512	c.65G>C	c.(64-66)aGa>aCa	p.R22T	RALGPS2_ENST00000367634.2_Intron|ANGPTL1_ENST00000367629.1_Missense_Mutation_p.R22T|RALGPS2_ENST00000367635.3_Intron|RALGPS2_ENST00000324778.4_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	22						extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						TTGTCCACCTCTGCAATGTCC	0.383													5	77					0	0	1	0	0	G	178834847	C	G	178834847	3	3	37	1	0	0	0	0	1	0	0	0	609	913	32	2	1426	2	ANGPTL1	1	178834847	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1989129	178834847	70415774	27	3342										
SOAT1	6646	broad.mit.edu	37	chr1	179320591	179320591	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcacgtcagcactgtcctctGaaaaatgtgagtcaccaacc	8	13	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:179320591G>A	ENST00000367619.3	+	15	1733	c.1590G>A	c.(1588-1590)ctG>ctA	p.L530L	SOAT1_ENST00000539888.1_Silent_p.L465L|SOAT1_ENST00000540564.1_Silent_p.L472L|SOAT1_ENST00000535686.1_Silent_p.L266L	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	530					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	ACTGTCCTCTGAAAAATGTGA	0.438													13	126					0	0	1	0	0	A	179320591	G	A	179320591	2	1	37	1	0	0	0	0	0	0	0	1	14963	1277	45	3		3	SOAT1	1	179320591	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	485744	179320591	69930030	28	3343										
HMCN1	83872	broad.mit.edu	37	chr1	186008973	186008973	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caagtctgacctggttgaaaGatgggagtcctgtttctagt	12	7	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:186008973G>C	ENST00000271588.4	+	39	6371	c.6142G>C	c.(6142-6144)Gat>Cat	p.D2048H	HMCN1_ENST00000367492.2_Missense_Mutation_p.D2048H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2048	Ig-like C2-type 18.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTGGTTGAAAGATGGGAGTCC	0.433													16	76					0	0	1	0	0	C	186008973	G	C	186008973	3	2	37	1	0	0	0	0	1	0	0	0	7260	942	33	2	6296	2	HMCN1	1	186008973	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6688382	186008973	63241648	29	3344										
TROVE2	6738	broad.mit.edu	37	chr1	193045690	193045690	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttactaaggaatctaggaaaGatgactgctaattcagtact	8	6	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:193045690G>C	ENST00000432079.1	+	3	604	c.36G>C	c.(34-36)aaG>aaC	p.K12N	TROVE2_ENST00000367444.3_Missense_Mutation_p.K287N|TROVE2_ENST00000460715.2_3'UTR|TROVE2_ENST00000367446.3_Missense_Mutation_p.K287N|TROVE2_ENST00000367441.1_Missense_Mutation_p.K287N|TROVE2_ENST00000367445.3_Missense_Mutation_p.K287N|TROVE2_ENST00000416058.2_Missense_Mutation_p.K12N|TROVE2_ENST00000367443.1_Missense_Mutation_p.K287N|TROVE2_ENST00000400968.2_Missense_Mutation_p.K287N			P10155	RO60_HUMAN	TROVE domain family, member 2	287					transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						ATCTAGGAAAGATGACTGCTA	0.338													8	67					0	0	1	0	0	C	193045690	G	C	193045690	3	2	37	1	0	0	0	0	1	0	0	0	16636	933	33	2	871	2	TROVE2	1	193045690	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	7036717	193045690	56204931	30	3345										
LHX9	56956	broad.mit.edu	37	chr1	197890533	197890533	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtctaccacctgagctgcttCacctgctccacttgcaacaa	6	16	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:197890533C>G	ENST00000367390.3	+	4	477	c.450C>G	c.(448-450)ttC>ttG	p.F150L	LHX9_ENST00000561173.1_Missense_Mutation_p.F165L|LHX9_ENST00000367387.4_Missense_Mutation_p.F159L|LHX9_ENST00000367391.1_Missense_Mutation_p.F150L|LHX9_ENST00000337020.2_Missense_Mutation_p.F159L	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	159	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						TGAGCTGCTTCACCTGCTCCA	0.597													4	94					0	0	1	0	0	G	197890533	C	G	197890533	3	3	37	1	0	0	0	0	1	0	0	0	8816	825	29	2	519	2	LHX9	1	197890533	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4844843	197890533	51360088	31	3346										
CHI3L1	1116	broad.mit.edu	37	chr1	203148584	203148584	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aacagagggctacgttgcagCgagtgcatccttgatggcat	13	9	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:203148584C>T	ENST00000255409.3	-	10	1266	c.1141G>A	c.(1141-1143)Gct>Act	p.A381T		NM_001276.2	NP_001267.2	P36222	CH3L1_HUMAN	chitinase 3-like 1 (cartilage glycoprotein-39)	381					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|skin(1)	18						TACGTTGCAGCGAGTGCATCC	0.647													10	123					0	0	1	0	0	T	203148584	C	T	203148584	3	4	37	1	0	0	0	0	1	0	0	0	3362	768	27	1	14	1	CHI3L1	1	203148584	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5258051	203148584	46102037	32	3347										
ATP2B4	493	broad.mit.edu	37	chr1	203693021	203693021	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgttctagattttcatcgtgGaatttgggggtaaacccttc	10	7	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:203693021G>C	ENST00000357681.5	+	19	4160	c.3037G>C	c.(3037-3039)Gaa>Caa	p.E1013Q	ATP2B4_ENST00000341360.2_Missense_Mutation_p.E1013Q|ATP2B4_ENST00000367218.3_Missense_Mutation_p.E1013Q|ATP2B4_ENST00000391954.2_Intron|ATP2B4_ENST00000367219.3_Missense_Mutation_p.E1001Q	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1013					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TTTCATCGTGGAATTTGGGGG	0.532													5	138					0	0	1	0	0	C	203693021	G	C	203693021	3	2	37	1	0	0	0	0	1	0	0	0	1141	1175	41	2	3107	2	ATP2B4	1	203693021	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	544437	203693021	45557600	33	3348										
YOD1	55432	broad.mit.edu	37	chr1	207222908	207222908	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcaagactcctccttcgacGacatagtacacactagtaaa	5	12	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:207222908G>A	ENST00000367084.1	-	4	576	c.372C>T	c.(370-372)gtC>gtT	p.V124V	YOD1_ENST00000315927.4_Silent_p.V168V|PFKFB2_ENST00000411990.2_5'UTR|YOD1_ENST00000391927.1_Silent_p.V124V	NM_001276320.1	NP_001263249.1	Q5VVQ6	OTU1_HUMAN	YOD1 deubiquitinase	168	UBX-like.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(3)	11	Prostate(682;0.19)					CTCCTTCGACGACATAGTACA	0.488													20	26					0	0	1	0	0	A	207222908	G	A	207222908	2	1	37	1	0	0	0	0	0	0	0	1	17547	1045	37	1		1	YOD1	1	207222908	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	3529887	207222908	42027713	34	3349										
LEFTY2	7044	broad.mit.edu	37	chr1	226125369	226125369	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggcaggtgcccacacactcGtaagccaggaagcccggggg	15	13	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:226125369G>A	ENST00000366820.5	-	4	1221	c.873C>T	c.(871-873)taC>taT	p.Y291Y	LEFTY2_ENST00000420304.2_Silent_p.Y257Y	NM_003240.3	NP_003231.2	O00292	LFTY2_HUMAN	left-right determination factor 2	291					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16	Breast(184;0.197)					CCACACACTCGTAAGCCAGGA	0.662													3	40					0	0	1	0	0	A	226125369	G	A	226125369	2	1	37	1	0	0	0	0	0	0	0	1	8754	1140	40	1		1	LEFTY2	1	226125369	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	18902461	226125369	23125252	35	3350										
C1orf35	79169	broad.mit.edu	37	chr1	228288913	228288913	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccccgcttcctcctcttacaGcagggggagttggagtcgga	13	13	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:228288913G>C	ENST00000272139.4	-	8	945	c.711C>G	c.(709-711)tgC>tgG	p.C237W	C1orf35_ENST00000472617.1_5'UTR	NM_024319.2	NP_077295.1	Q9BU76	MMTA2_HUMAN	chromosome 1 open reading frame 35	237										large_intestine(1)|lung(1)|skin(1)	3		Prostate(94;0.0488)				TCCTCTTACAGCAGGGGGAGT	0.642													6	59					0	0	1	0	0	C	228288913	G	C	228288913	3	2	37	1	0	0	0	0	1	0	0	0	2052	963	34	5	84	5	C1orf35	1	228288913	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2163544	228288913	20961708	36	3351										
PGBD5	79605	broad.mit.edu	37	chr1	230459297	230459297	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tacaggatgtaggcattgttGatggcgatgctgatggcgaa	15	5	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:230459297G>C	ENST00000321327.2	-	9	1538	c.1539C>G	c.(1537-1539)atC>atG	p.I513M	PGBD5_ENST00000530424.1_5'UTR|PGBD5_ENST00000525115.1_Missense_Mutation_p.I414M|PGBD5_ENST00000391860.1_Missense_Mutation_p.I368M			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	414						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		AGGCATTGTTGATGGCGATGC	0.517													15	111					0	0	1	0	0	C	230459297	G	C	230459297	3	2	37	1	0	0	0	0	1	0	0	0	11831	1280	45	2	129	2	PGBD5	1	230459297	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2170384	230459297	18791324	37	3352										
DISC1	27185	broad.mit.edu	37	chr1	231935886	231935886	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gagaaattctgcagcaccctGaggaagaaagttaacgatat	10	7	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:231935886G>A	ENST00000439617.2	+	8	1775	c.1722G>A	c.(1720-1722)ctG>ctA	p.L574L	TRAX_ENST00000602962.1_3'UTR|DISC1_ENST00000602873.1_Intron|DISC1_ENST00000602281.1_Silent_p.L574L|DISC1_ENST00000366637.3_5'UTR|DISC1_ENST00000366633.3_Silent_p.L574L|DISC1_ENST00000366636.4_Silent_p.L574L|DISC1_ENST00000535983.1_Silent_p.L574L|DISC1_ENST00000539444.1_Intron|DISC1_ENST00000537876.1_Intron	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	574	Interaction with TRAF3IP1.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Required for localization to punctate cytoplasmic foci.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				GCAGCACCCTGAGGAAGAAAG	0.448													4	51					0	0	1	0	0	A	231935886	G	A	231935886	2	1	37	1	0	0	0	0	0	0	0	1	4566	1277	45	3		3	DISC1	1	231935886	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1476589	231935886	17314735	38	3353										
OR2T3	343173	broad.mit.edu	37	chr1	248637188	248637188	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttttgccagtctaggaaaatCctgagttttttctgtgagac	9	7	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:248637188C>T	ENST00000359594.2	+	1	562	c.537C>T	c.(535-537)atC>atT	p.I179I		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTAGGAAAATCCTGAGTTTTT	0.522													4	131					0	0	1	0	0	T	248637188	C	T	248637188	2	4	37	1	0	0	0	0	0	0	0	1	11070	845	30	3		3	OR2T3	1	248637188	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	16701302	248637188	613433	39	3354										
OR2T34	127068	broad.mit.edu	37	chr1	248737522	248737522	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtctcacagaaaaaactcagGattttcctagactggcaaaa	7	9	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr1:248737522G>A	ENST00000328782.2	-	1	558	c.537C>T	c.(535-537)atC>atT	p.I179I		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAAACTCAGGATTTTCCTAG	0.522													20	43					0	0	1	0	0	A	248737522	G	A	248737522	2	1	37	1	0	0	0	0	0	0	0	1	11072	1164	41	3		3	OR2T34	1	248737522	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	100334	248737522	513099	40	3355										
WDR35	57539	broad.mit.edu	37	chr2	20114033	20114033	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtcttcatagtctttcaggtGaagagctaagaaaaacaggg	11	6	4	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:20114033G>A	ENST00000345530.3	-	27	3275	c.3160C>T	c.(3160-3162)Cac>Tac	p.H1054Y	WDR35_ENST00000416055.2_Intron|WDR35_ENST00000281405.4_Missense_Mutation_p.H1043Y	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	1054										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTTCAGGTGAAGAGCTAAG	0.398													8	61					0	0	1	0	0	A	20114033	G	A	20114033	3	1	37	1	0	0	0	0	1	0	0	0	17348	1290	45	3	393	3	WDR35	2	20114033	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		20114033	223085340	41	3356										
FKBP1B	2281	broad.mit.edu	37	chr2	24285898	24285898	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tttaaatcaagctgggtcctCtttctcctctccccatctgc	5	15	5	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:24285898C>G	ENST00000380991.4	+	4	357	c.208C>G	c.(208-210)Ctt>Gtt	p.L70V	FKBP1B_ENST00000452109.1_Intron|FKBP1B_ENST00000380986.4_Intron			P68106	FKB1B_HUMAN	FK506 binding protein 1B, 12.6 kDa	0	PPIase FKBP-type.				'de novo' protein folding|negative regulation of heart rate|negative regulation of protein phosphatase type 2B activity|protein maturation by protein folding|protein refolding|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of ryanodine-sensitive calcium-release channel activity|response to redox state	calcium channel complex|sarcoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor binding			lung(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGGGTCCTCTTTCTCCTCT	0.488													4	24					0	0	1	0	0	G	24285898	C	G	24285898	3	3	37	1	0	0	0	0	1	0	0	0	5939	913	32	2	222	2	FKBP1B	2	24285898	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4171865	24285898	218913475	42	3357										
ITSN2	50618	broad.mit.edu	37	chr2	24484527	24484527	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcacttgatggcattttttCtacataattgcatggaaacc	6	8	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:24484527C>G	ENST00000355123.4	-	21	2883	c.2440G>C	c.(2440-2442)Gaa>Caa	p.E814Q	ITSN2_ENST00000406921.3_Missense_Mutation_p.E814Q|ITSN2_ENST00000361999.3_Missense_Mutation_p.E787Q	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	814	SH3 1.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCATTTTTTCTACATAATTG	0.378													6	37					0	0	1	0	0	G	24484527	C	G	24484527	3	3	37	1	0	0	0	0	1	0	0	0	7970	922	32	2	2784	2	ITSN2	2	24484527	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	198629	24484527	218714846	43	3358										
OTOF	9381	broad.mit.edu	37	chr2	26725246	26725246	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gatccagtccatctcctagcCgaatggccagatggtcaagg	11	12	2	1	rs111033535		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:26725246C>T	ENST00000272371.2	-	7	758	c.632G>A	c.(631-633)cGg>cAg	p.R211Q	OTOF_ENST00000403946.3_Missense_Mutation_p.R211Q	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	211					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCTCCTAGCCGAATGGCCAG	0.557													4	21					0	0	1	0	0	T	26725246	C	T	26725246	3	4	37	1	0	0	0	0	1	0	0	0	11349	652	23	1	5850	1	OTOF	2	26725246	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2240719	26725246	216474127	44	3359										
GTF3C2	2976	broad.mit.edu	37	chr2	27566241	27566241	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctctgatcaggagaatcctCaaatccaggcaaaggggtag	11	10	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:27566241C>G	ENST00000359541.2	-	2	610	c.181G>C	c.(181-183)Gag>Cag	p.E61Q	GTF3C2_ENST00000264720.3_Missense_Mutation_p.E61Q			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	61						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGAATCCTCAAATCCAGGC	0.488													22	189					0	0	1	0	0	G	27566241	C	G	27566241	3	3	37	1	0	0	0	0	1	0	0	0	6913	835	29	2	2626	2	GTF3C2	2	27566241	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	840995	27566241	215633132	45	3360										
ZNF513	130557	broad.mit.edu	37	chr2	27600930	27600930	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggccaggtggttgggatagtGagtggcaaaggggcagaggc	21	5	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:27600930G>C	ENST00000323703.6	-	4	1306	c.1108C>G	c.(1108-1110)Cac>Gac	p.H370D	ZNF513_ENST00000491924.1_Intron|ZNF513_ENST00000407879.1_Missense_Mutation_p.H308D	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	370					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGGGATAGTGAGTGGCAAAG	0.632													18	150					0	0	1	0	0	C	27600930	G	C	27600930	3	2	37	1	0	0	0	0	1	0	0	0	18014	1290	45	2	521	2	ZNF513	2	27600930	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	34689	27600930	215598443	46	3361										
C2orf16	84226	broad.mit.edu	37	chr2	27803866	27803866	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctcagtggggcagcctctgaGaactgttcaaaaggacagta	12	9	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:27803866G>C	ENST00000408964.2	+	1	4478	c.4427G>C	c.(4426-4428)aGa>aCa	p.R1476T		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1476										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CAGCCTCTGAGAACTGTTCAA	0.473													18	139					0	0	1	0	0	C	27803866	G	C	27803866	3	2	37	1	0	0	0	0	1	0	0	0	2171	942	33	2	4429	2	C2orf16	2	27803866	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	202936	27803866	215395507	47	3362										
HEATR5B	54497	broad.mit.edu	37	chr2	37291994	37291994	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggtgaggtcttcaagttgttGagccgttctgcacacctgtc	12	10	3	2	rs142538657		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:37291994G>C	ENST00000233099.5	-	10	1568	c.1473C>G	c.(1471-1473)ctC>ctG	p.L491L	HEATR5B_ENST00000354531.2_Silent_p.L491L	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	491							binding	p.L491L(1)		breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				TCAAGTTGTTGAGCCGTTCTG	0.507													22	44					0	0	1	0	0	C	37291994	G	C	37291994	2	2	37	1	0	0	0	0	0	0	0	1	7072	1277	45	2		2	HEATR5B	2	37291994	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	9488128	37291994	205907379	48	3363										
PRKCE	5581	broad.mit.edu	37	chr2	46203651	46203651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccgtcaggcgcagggtccatCaggtcaacggccacaagttc	12	14	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:46203651C>G	ENST00000306156.3	+	3	823	c.496C>G	c.(496-498)Cag>Gag	p.Q166E		NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	166					activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CAGGGTCCATCAGGTCAACGG	0.587													29	90					0	0	1	0	0	G	46203651	C	G	46203651	3	3	37	1	0	0	0	0	1	0	0	0	12562	827	29	2	506	2	PRKCE	2	46203651	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	8911657	46203651	196995722	49	3364										
LHCGR	3973	broad.mit.edu	37	chr2	48915596	48915596	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagaaagttcacttgcgaatAcagtgaaaaagccagcagtg	10	8	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:48915596A>G	ENST00000294954.7	-	11	1361	c.1340T>C	c.(1339-1341)gTa>gCa	p.V447A	LHCGR_ENST00000344775.3_Missense_Mutation_p.V385A|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Missense_Mutation_p.V420A|LHCGR_ENST00000403273.1_3'UTR|LHCGR_ENST00000401907.1_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	447					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	ACTTGCGAATACAGTGAAAAA	0.488													11	75					0	0	1	0	0	G	48915596	A	G	48915596	3	3	37	1	0	0	0	0	1	0	0	0	8801	391	14	4	763	4	LHCGR	2	48915596	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	2711945	48915596	194283777	50	3365										
EHBP1	23301	broad.mit.edu	37	chr2	63053311	63053311	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atgccaactcagactgatgtCaagttaaaattcaagccatt	6	9	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:63053311C>A	ENST00000263991.5	+	6	884	c.402C>A	c.(400-402)gtC>gtA	p.V134V	EHBP1_ENST00000405289.1_Silent_p.V134V|EHBP1_ENST00000354487.3_Silent_p.V134V|AC007098.1_ENST00000452397.1_RNA|EHBP1_ENST00000405015.3_Silent_p.V134V|EHBP1_ENST00000431489.1_Silent_p.V134V	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	134						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			AGACTGATGTCAAGTTAAAAT	0.398													7	41					0.00198382	0.0020305	1	1	0	A	63053311	C	A	63053311	2	1	37	1	0	0	0	0	0	0	0	1	5001	813	29	2		2	EHBP1	2	63053311	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	14137715	63053311	180146062	51	3366										
GPAT2	150763	broad.mit.edu	37	chr2	96690526	96690526	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cattgcaccccctaccttctGatgcttgaagagcagcagcg	9	14	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:96690526G>A	ENST00000434632.1	-	15	1882	c.1423C>T	c.(1423-1425)Cag>Tag	p.Q475*	GPAT2_ENST00000359548.4_Nonsense_Mutation_p.Q475*|GPAT2_ENST00000377137.3_Nonsense_Mutation_p.Q475*|GPAT2_ENST00000453542.1_Nonsense_Mutation_p.Q404*			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	475					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						CCTACCTTCTGATGCTTGAAG	0.652													22	265					0	0	1	0	0	A	96690526	G	A	96690526	4	1	37	1	0	0	0	0	0	1	0	0	6628	1299	45	3	1000	3	GPAT2	2	96690526	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	33637215	96690526	146508847	52	3367										
MGAT4A	11320	broad.mit.edu	37	chr2	99294911	99294911	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttctttcaaagcaaggaattCtcgttgataagcaatcagtt	7	7	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:99294911C>G	ENST00000393487.1	-	3	431	c.118G>C	c.(118-120)Gaa>Caa	p.E40Q	MGAT4A_ENST00000264968.2_Missense_Mutation_p.E40Q|MGAT4A_ENST00000409391.1_Missense_Mutation_p.E40Q	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	40					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						GCAAGGAATTCTCGTTGATAA	0.338													5	26					0	0	1	0	0	G	99294911	C	G	99294911	3	3	37	1	0	0	0	0	1	0	0	0	9594	922	32	2	1647	2	MGAT4A	2	99294911	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2604385	99294911	143904462	53	3368										
REV1	51455	broad.mit.edu	37	chr2	100022444	100022444	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acaggagtatgtagaccattCcatttccctgaagactcagc	8	11	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:100022444C>G	ENST00000258428.3	-	17	2967	c.2739G>C	c.(2737-2739)tgG>tgC	p.W913C	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Missense_Mutation_p.W912C	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	913					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTAGACCATTCCATTTCCCTG	0.443								Direct reversal of damage					3	47					0	0	1	0	0	G	100022444	C	G	100022444	3	3	37	1	0	0	0	0	1	0	0	0	13290	856	30	2	1044	2	REV1	2	100022444	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	727533	100022444	143176929	54	3369										
IL1R1	3554	broad.mit.edu	37	chr2	102792941	102792941	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aaatagccatgtataatgctCttgttcaggatggaattaaa	8	5	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:102792941C>G	ENST00000410023.1	+	12	1750	c.1432C>G	c.(1432-1434)Ctt>Gtt	p.L478V	IL1R1_ENST00000424272.1_3'UTR|IL1R1_ENST00000409929.1_Missense_Mutation_p.L447V|AC007271.3_ENST00000428188.1_RNA|IL1R1_ENST00000409589.1_Intron|IL1R1_ENST00000233946.3_Missense_Mutation_p.L478V			P14778	IL1R1_HUMAN	interleukin 1 receptor, type I	478	TIR.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(2)|skin(3)	19					Anakinra(DB00026)	GTATAATGCTCTTGTTCAGGA	0.388													5	45					0	0	1	0	0	G	102792941	C	G	102792941	3	3	37	1	0	0	0	0	1	0	0	0	7701	913	32	2	1470	2	IL1R1	2	102792941	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2770497	102792941	140406432	55	3370										
DPP10	57628	broad.mit.edu	37	chr2	116548751	116548751	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aaaatccttcatattgacgaCtatggtaaaattttgtgcat	6	6	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:116548751C>G	ENST00000410059.1	+	18	2106	c.1626C>G	c.(1624-1626)gaC>gaG	p.D542E	DPP10_ENST00000310323.8_Missense_Mutation_p.D535E|DPP10_ENST00000393147.2_Missense_Mutation_p.D546E|DPP10_ENST00000409163.1_Missense_Mutation_p.D492E	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	542					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						ATATTGACGACTATGGTAAAA	0.323													4	30					0	0	1	0	0	G	116548751	C	G	116548751	3	3	37	1	0	0	0	0	1	0	0	0	4753	564	20	5	1867	5	DPP10	2	116548751	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	13755810	116548751	126650622	56	3371										
LRP1B	53353	broad.mit.edu	37	chr2	140990855	140990855	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcgacagttttgcccatccAtatataattttgcatatacc	4	10	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:140990855A>G	ENST00000389484.3	-	91	14671	c.13700T>C	c.(13699-13701)aTg>aCg	p.M4567T		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4567					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGCCCATCCATATATAATTT	0.323										TSP Lung(27;0.18)			4	26					0	0	1	0	0	G	140990855	A	G	140990855	3	3	37	1	0	0	0	0	1	0	0	0	8999	217	8	4	103	4	LRP1B	2	140990855	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	24442104	140990855	102208518	57	3372										
MBD5	0	broad.mit.edu	37	chr2	149241016	149241016	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcaggagaaggcaagtctgaGatcaacctccaccctttagg	11	11	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:149241016G>C	ENST00000404807.1	+	5	2985	c.2856G>C	c.(2854-2856)gaG>gaC	p.E952D	MBD5_ENST00000407073.1_Intron			Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	957						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GCAAGTCTGAGATCAACCTCC	0.453													10	71					0	0	1	0	0	C	149241016	G	C	149241016	3	2	37	1	0	0	0	0	1	0	0	0	9396	957	33	2		2	MBD5	2	149241016	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	8250161	149241016	93958357	58	3373										
LRP2	4036	broad.mit.edu	37	chr2	170058204	170058204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	accattgcagataaactcacGaggtatgcaccttctgttat	7	10	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:170058204G>A	ENST00000263816.3	-	44	8671	c.8386C>T	c.(8386-8388)Cgt>Tgt	p.R2796C		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2796	LDL-receptor class A 18.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATAAACTCACGAGGTATGCAC	0.433													5	64					0	0	1	0	0	A	170058204	G	A	170058204	3	1	37	1	0	0	0	0	1	0	0	0	9000	1058	37	1	5725	1	LRP2	2	170058204	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	20817188	170058204	73141169	59	3374										
LRP2	4036	broad.mit.edu	37	chr2	170062596	170062596	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gggctatcacagtgcggttaGacccatcttcagccatggaa	11	11	3	1	rs142613860		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:170062596G>A	ENST00000263816.3	-	40	7778	c.7493C>T	c.(7492-7494)tCt>tTt	p.S2498F		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2498					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGTGCGGTTAGACCCATCTTC	0.438													19	99					0	0	1	0	0	A	170062596	G	A	170062596	3	1	37	1	0	0	0	0	1	0	0	0	9000	942	33	3	6634	3	LRP2	2	170062596	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4392	170062596	73136777	60	3375										
NFE2L2	4780	broad.mit.edu	37	chr2	178095660	178095660	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acttcgagatataaggtgctGagttgttttttcagtaggtg	12	4	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:178095660G>C	ENST00000397062.3	-	5	2225	c.1671C>G	c.(1669-1671)ctC>ctG	p.L557L	NFE2L2_ENST00000464747.1_Silent_p.L541L|NFE2L2_ENST00000446151.2_Silent_p.L534L|NFE2L2_ENST00000397063.4_Silent_p.L541L	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	557					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ATAAGGTGCTGAGTTGTTTTT	0.363			Mis		"NSCLC, HNSCC"					HNSCC(56;0.16)			8	93					0	0	1	0	0	C	178095660	G	C	178095660	2	2	37	1	0	0	0	0	0	0	0	1	10414	1277	45	2		2	NFE2L2	2	178095660	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	8033064	178095660	65103713	61	3376										
NFE2L2	4780	broad.mit.edu	37	chr2	178095740	178095740	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttctttttcatctttcaaatGatctaaatcttgctctagtt	3	8	7	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:178095740G>A	ENST00000397062.3	-	5	2145	c.1591C>T	c.(1591-1593)Cat>Tat	p.H531Y	NFE2L2_ENST00000464747.1_Missense_Mutation_p.H515Y|NFE2L2_ENST00000446151.2_Missense_Mutation_p.H508Y|NFE2L2_ENST00000397063.4_Missense_Mutation_p.H515Y	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	531	Leucine-zipper.				transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCTTTCAAATGATCTAAATCT	0.343			Mis		"NSCLC, HNSCC"					HNSCC(56;0.16)			9	60					0	0	1	0	0	A	178095740	G	A	178095740	3	1	37	1	0	0	0	0	1	0	0	0	10414	1290	45	3	230	3	NFE2L2	2	178095740	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	80	178095740	65103633	62	3377										
TTN	7273	broad.mit.edu	37	chr2	179411742	179411742	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atacataccaactggattttGagccattataggtcttgaag	8	7	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:179411742G>C	ENST00000589042.1	-	340	94734	c.94510C>G	c.(94510-94512)Caa>Gaa	p.Q31504E	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Q22631E|TTN_ENST00000342992.6_Missense_Mutation_p.Q28936E|TTN_ENST00000591111.1_Missense_Mutation_p.Q29863E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Q22564E|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.Q22439E|TTN-AS1_ENST00000590932.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29863	Ig-like 140.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGGATTTTGAGCCATTATA	0.363													19	113					0	0	1	0	0	C	179411742	G	C	179411742	3	2	37	1	0	0	0	0	1	0	0	0	16796	1299	45	2	13561	2	TTN	2	179411742	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1316002	179411742	63787631	63	3378										
TTN	7273	broad.mit.edu	37	chr2	179632801	179632801	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtacagtgatgtcaggttcaGaaacttcacattcaaacatg	8	8	4	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:179632801G>A	ENST00000589042.1	-	39	9469	c.9245C>T	c.(9244-9246)tCt>tTt	p.S3082F	TTN_ENST00000360870.5_Missense_Mutation_p.S3082F|TTN_ENST00000342175.6_Missense_Mutation_p.S3036F|TTN_ENST00000342992.6_Missense_Mutation_p.S3082F|TTN_ENST00000591111.1_Missense_Mutation_p.S3082F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S3036F|TTN_ENST00000460472.2_Missense_Mutation_p.S3036F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2819	Ig-like 18.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCAGGTTCAGAAACTTCACA	0.408													7	51					0	0	1	0	0	A	179632801	G	A	179632801	3	1	37	1	0	0	0	0	1	0	0	0	16796	942	33	3	102039	3	TTN	2	179632801	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	221059	179632801	63566572	64	3379										
STAT1	6772	broad.mit.edu	37	chr2	191844515	191844515	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tacccatcattccagagaggGagcaggtgttttttaatgag	11	7	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:191844515G>T	ENST00000361099.3	-	20	2097	c.1710C>A	c.(1708-1710)ctC>ctA	p.L570L	STAT1_ENST00000540176.1_3'UTR|STAT1_ENST00000409465.1_Silent_p.L570L|STAT1_ENST00000392322.3_Silent_p.L570L|STAT1_ENST00000392323.2_Silent_p.L572L	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	570					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TCCAGAGAGGGAGCAGGTGTT	0.388													4	28					0.00909568	0.00922289	1	1	0	T	191844515	G	T	191844515	2	4	37	1	0	0	0	0	0	0	0	1	15319	1161	41	2		2	STAT1	2	191844515	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	12211714	191844515	51354858	65	3380										
TRAK2	66008	broad.mit.edu	37	chr2	202245467	202245467	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttctcttgggcaccagggttCttgaccactctggctatccc	9	14	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:202245467C>G	ENST00000332624.3	-	16	2972	c.2544G>C	c.(2542-2544)aaG>aaC	p.K848N		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	848				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						CACCAGGGTTCTTGACCACTC	0.478													12	96					0	0	1	0	0	G	202245467	C	G	202245467	3	3	37	1	0	0	0	0	1	0	0	0	16510	912	32	2	204	2	TRAK2	2	202245467	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10400952	202245467	40953906	66	3381										
ZDBF2	57683	broad.mit.edu	37	chr2	207173234	207173234	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gctatgtgcccagtgattctGaaataatttatgtttcaaat	7	6	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:207173234G>C	ENST00000374423.3	+	5	4368	c.3982G>C	c.(3982-3984)Gaa>Caa	p.E1328Q		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1328							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CAGTGATTCTGAAATAATTTA	0.383													5	42					0	0	1	0	0	C	207173234	G	C	207173234	3	2	37	1	0	0	0	0	1	0	0	0	17656	1291	45	2	3992	2	ZDBF2	2	207173234	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4927767	207173234	36026139	67	3382										
ABCA12	26154	broad.mit.edu	37	chr2	215852431	215852431	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	catgaggccattgctcttctCaggcttcacctctgcacacc	7	16	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:215852431C>G	ENST00000272895.7	-	27	4135	c.3916G>C	c.(3916-3918)Gag>Cag	p.E1306Q	ABCA12_ENST00000389661.4_Missense_Mutation_p.E988Q	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1306					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTGCTCTTCTCAGGCTTCACC	0.458													9	27					0	0	1	0	0	G	215852431	C	G	215852431	3	3	37	1	0	0	0	0	1	0	0	0	30	835	29	2	3979	2	ABCA12	2	215852431	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	8679197	215852431	27346942	68	3383										
IRS1	3667	broad.mit.edu	37	chr2	227662588	227662588	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggctgggcgggggattgttGagatggtgccggcgcagggg	23	6	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:227662588G>C	ENST00000305123.4	-	1	1887	c.867C>G	c.(865-867)ctC>ctG	p.L289L		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	289	Ser-rich.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GGGGATTGTTGAGATGGTGCC	0.672											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	108					0	0	1	0	0	C	227662588	G	C	227662588	2	2	37	1	0	0	0	0	0	0	0	1	7883	1277	45	2		2	IRS1	2	227662588	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	11810157	227662588	15536785	69	3384										
SPHKAP	80309	broad.mit.edu	37	chr2	228855726	228855726	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tacatgataccttttcaattCtgttttcctgagatttctta	4	8	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:228855726C>G	ENST00000392056.3	-	11	4995	c.4949G>C	c.(4948-4950)aGa>aCa	p.R1650T	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R1621T	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1650						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTTTTCAATTCTGTTTTCCTG	0.453													7	76					0	0	1	0	0	G	228855726	C	G	228855726	3	3	37	1	0	0	0	0	1	0	0	0	15103	913	32	2	161	2	SPHKAP	2	228855726	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1193138	228855726	14343647	70	3385										
CHRND	1144	broad.mit.edu	37	chr2	233393337	233393337	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tctgtcacctatttccccttCgactggcagaactgctccct	6	16	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:233393337C>T	ENST00000457943.2	+	5	508	c.209C>T	c.(208-210)tCg>tTg	p.S70L	CHRND_ENST00000258385.3_Silent_p.F160F|CHRND_ENST00000536614.1_Silent_p.F160F|CHRND_ENST00000543200.1_Silent_p.F145F			Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	0					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity	p.F160F(1)		breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		ATTTCCCCTTCGACTGGCAGA	0.577													24	115					0	0	1	0	0	T	233393337	C	T	233393337	3	4	37	1	0	0	0	0	1	0	0	0	3416	883	31	1	498	1	CHRND	2	233393337	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4537611	233393337	9806036	71	3386										
SEPT2	4735	broad.mit.edu	37	chr2	242274603	242274603	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcctaactgatctgtacccaGaaagagtcatacctggagca	8	11	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr2:242274603G>A	ENST00000391973.2	+	4	721	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	SEPT2_ENST00000360051.3_Missense_Mutation_p.E65K|SEPT2_ENST00000402092.2_Missense_Mutation_p.E65K|SEPT2_ENST00000391971.2_Missense_Mutation_p.E65K|SEPT2_ENST00000401990.1_Missense_Mutation_p.E65K|SEPT2_ENST00000407971.1_Missense_Mutation_p.E25K	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	65					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		TCTGTACCCAGAAAGAGTCAT	0.348													3	17					0	0	1	0	0	A	242274603	G	A	242274603	3	1	37	1	0	0	0	0	1	0	0	0	14117	943	33	3	203	3	SEPT2	2	242274603	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	8881266	242274603	924770	72	3387										
CRBN	51185	broad.mit.edu	37	chr3	3214548	3214548	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctcaattccaaaatcctgttCttctcgataggcatatatct	4	11	4	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:3214548C>T	ENST00000231948.4	-	4	461	c.439G>A	c.(439-441)Gaa>Aaa	p.E147K	CRBN_ENST00000432408.2_Missense_Mutation_p.E146K	NM_016302.3	NP_057386.2	Q96SW2	CRBN_HUMAN	cereblon	147	Lon.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	11				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		AAATCCTGTTCTTCTCGATAG	0.363													8	53					0	0	1	0	0	T	3214548	C	T	3214548	3	4	37	1	0	0	0	0	1	0	0	0	3874	922	32	3	921	3	CRBN	3	3214548	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08		3214548	194807882	73	3388										
TMEM43	79188	broad.mit.edu	37	chr3	14177406	14177406	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	accacggggacttctcagcaGaggtgagtgctgtgccctac	13	12	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:14177406G>C	ENST00000306077.4	+	10	1134	c.880G>C	c.(880-882)Gag>Cag	p.E294Q		NM_024334.2	NP_077310.1	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	294						endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				breast(1)|cervix(3)|endometrium(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(2)	19						CTTCTCAGCAGAGGTGAGTGC	0.552													5	68					0	0	1	0	0	C	14177406	G	C	14177406	3	2	37	1	0	0	0	0	1	0	0	0	16226	943	33	2	918	2	TMEM43	3	14177406	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	10962858	14177406	183845024	74	3389										
UBP1	7342	broad.mit.edu	37	chr3	33450944	33450944	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgggttctctgtcttaccttAaaaactttgatttggcagct	8	9	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:33450944A>C	ENST00000283629.3	-	6	1234	c.705T>G	c.(703-705)ttT>ttG	p.F235L	UBP1_ENST00000447368.2_Missense_Mutation_p.F235L|UBP1_ENST00000283628.5_Missense_Mutation_p.F235L	NM_001128161.1|NM_014517.4	NP_001121633.1|NP_055332.3	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a)	235					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|urinary_tract(2)	23						GTCTTACCTTAAAAACTTTGA	0.408													12	54					0	0	1	0	0	C	33450944	A	C	33450944	3	2	37	1	0	0	0	0	1	0	0	0	16955	359	13	4	961	4	UBP1	3	33450944	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	19273538	33450944	164571486	75	3390										
TGM4	7047	broad.mit.edu	37	chr3	44952512	44952512	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acagcctggctatattagatGatgagccagttatcagaggt	11	7	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:44952512G>C	ENST00000296125.4	+	12	1737	c.1669G>C	c.(1669-1671)Gat>Cat	p.D557H		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	557					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TATATTAGATGATGAGCCAGT	0.463													6	31					0	0	1	0	0	C	44952512	G	C	44952512	3	2	37	1	0	0	0	0	1	0	0	0	15891	1290	45	2	1715	2	TGM4	3	44952512	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	11501568	44952512	153069918	76	3391										
MST1	4485	broad.mit.edu	37	chr3	49723897	49723897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gacagttgtggcctcttggcGgggctgtgcctcggaccctt	15	12	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:49723897G>A	ENST00000449682.2	-	8	1226	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C	MST1_ENST00000545762.1_3'UTR|MST1_ENST00000383728.3_Missense_Mutation_p.R214C	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	275	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCTCTTGGCGGGGCTGTGCC	0.657													4	27					0	0	1	0	0	A	49723897	G	A	49723897	3	1	37	1	0	0	0	0	1	0	0	0	9937	1116	39	1	1356	1	MST1	3	49723897	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4771385	49723897	148298533	77	3392										
PBRM1	55193	broad.mit.edu	37	chr3	52696199	52696199	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccatcttcatcatcatcttCgtcatctgcttctcctttct	2	16	9	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:52696199C>T	ENST00000356770.4	-	4	480	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K	PBRM1_ENST00000409767.1_Missense_Mutation_p.E160K|PBRM1_ENST00000410007.1_Missense_Mutation_p.E160K|PBRM1_ENST00000409114.3_Missense_Mutation_p.E160K|PBRM1_ENST00000409057.1_Missense_Mutation_p.E160K|PBRM1_ENST00000394830.3_Missense_Mutation_p.E160K|PBRM1_ENST00000337303.4_Missense_Mutation_p.E160K|PBRM1_ENST00000296302.7_Missense_Mutation_p.E160K			Q86U86	PB1_HUMAN	polybromo 1	160			E -> A (found in a malignant melanoma cell line).		chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.E160*(3)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCATCATCTTCGTCATCTGCT	0.453			"Mis, N, F, S, D, O"		"clear cell renal carcinoma, breast"								28	172					0	0	1	0	0	T	52696199	C	T	52696199	3	4	37	1	0	0	0	0	1	0	0	0	11537	893	31	1	4530	1	PBRM1	3	52696199	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2972302	52696199	145326231	78	3393										
ZBTB11	27107	broad.mit.edu	37	chr3	101370146	101370146	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tactttggtcagaaagtgtaGataccgatggatactcttca	9	7	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:101370146G>C	ENST00000312938.4	-	11	3606	c.3026C>G	c.(3025-3027)tCt>tGt	p.S1009C		NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	1009					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						AGAAAGTGTAGATACCGATGG	0.418													7	85					0	0	1	0	0	C	101370146	G	C	101370146	3	2	37	1	0	0	0	0	1	0	0	0	17582	942	33	2	139	2	ZBTB11	3	101370146	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	48673947	101370146	96652284	79	3394										
CBLB	868	broad.mit.edu	37	chr3	105438994	105438994	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aggggtcaatgatgctgcaaCacctggagccttcatctctt	10	11	3	1	rs116474782	by1000genomes	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:105438994C>G	ENST00000264122.4	-	10	1625	c.1304G>C	c.(1303-1305)tGt>tCt	p.C435S	CBLB_ENST00000394027.3_Missense_Mutation_p.C457S|CBLB_ENST00000403724.1_Missense_Mutation_p.C435S|CBLB_ENST00000405772.1_Missense_Mutation_p.C435S|CBLB_ENST00000545639.1_3'UTR	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	435					cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						GATGCTGCAACACCTGGAGCC	0.512			Mis S		AML								5	30					0	0	1	0	0	G	105438994	C	G	105438994	3	3	37	1	0	0	0	0	1	0	0	0	2719	478	17	5	1684	5	CBLB	3	105438994	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4068848	105438994	92583436	80	3395										
ZNF80	7634	broad.mit.edu	37	chr3	113955901	113955901	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agaccatcacctgtccccaaCccatcgcgtttagggctcat	7	16	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:113955901C>T	ENST00000482457.2	-	1	524	c.21G>A	c.(19-21)ggG>ggA	p.G7G		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	7						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CTGTCCCCAACCCATCGCGTT	0.527													9	94					0	0	1	0	0	T	113955901	C	T	113955901	2	4	37	1	0	0	0	0	0	0	0	1	18216	494	18	3		3	ZNF80	3	113955901	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	8516907	113955901	84066529	81	3396										
STXBP5L	9515	broad.mit.edu	37	chr3	121126326	121126326	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aagtcttctcactgccttctCagacttgcctttatgttcat	5	12	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:121126326C>G	ENST00000273666.6	+	24	3167	c.2896C>G	c.(2896-2898)Cag>Gag	p.Q966E	STXBP5L_ENST00000471454.1_Missense_Mutation_p.Q942E|STXBP5L_ENST00000472879.1_Missense_Mutation_p.Q942E|STXBP5L_ENST00000497029.1_Missense_Mutation_p.Q940E|STXBP5L_ENST00000492541.1_Missense_Mutation_p.Q966E	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	966					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ACTGCCTTCTCAGACTTGCCT	0.418													12	71					0	0	1	0	0	G	121126326	C	G	121126326	3	3	37	1	0	0	0	0	1	0	0	0	15412	827	29	2	2986	2	STXBP5L	3	121126326	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	7170425	121126326	76896104	82	3397										
GOLGB1	2804	broad.mit.edu	37	chr3	121414560	121414560	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttgccactcagtactttctgCaatcttagaagatttcaaag	6	9	4	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:121414560C>T	ENST00000393667.3	-	13	4920	c.4810G>A	c.(4810-4812)Gca>Aca	p.A1604T	GOLGB1_ENST00000340645.5_Missense_Mutation_p.A1599T	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1599					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		GTACTTTCTGCAATCTTAGAA	0.378													18	57					0	0	1	0	0	T	121414560	C	T	121414560	3	4	37	1	0	0	0	0	1	0	0	0	6603	710	25	3	5024	3	GOLGB1	3	121414560	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	288234	121414560	76607870	83	3398										
TMCC1	23023	broad.mit.edu	37	chr3	129547175	129547175	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctgcatcttgggatttgcctCcaggatcagggtcctcaaat	10	11	3	0	rs114855835	by1000genomes	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:129547175C>G	ENST00000393238.3	-	3	387	c.47G>C	c.(46-48)gGa>gCa	p.G16A	TMCC1_ENST00000426664.2_Intron	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	16						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GGATTTGCCTCCAGGATCAGG	0.403													7	65					0	0	1	0	0	G	129547175	C	G	129547175	3	3	37	1	0	0	0	0	1	0	0	0	16051	855	30	2	1930	2	TMCC1	3	129547175	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	8132615	129547175	68475255	84	3399										
BFSP2	8419	broad.mit.edu	37	chr3	133185774	133185774	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgtgccaagtccagagcctcCaggctgagacagaatcctta	10	13	0	3	rs140878916		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:133185774C>A	ENST00000302334.2	+	5	1083	c.994C>A	c.(994-996)Cag>Aag	p.Q332K	BFSP2_ENST00000511434.1_3'UTR	NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	332	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						CCAGAGCCTCCAGGCTGAGAC	0.537													6	68					2.0095e-06	2.12168e-06	1	1	0	A	133185774	C	A	133185774	3	1	37	1	0	0	0	0	1	0	0	0	1415	595	21	5	1012	5	BFSP2	3	133185774	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3638599	133185774	64836656	85	3400										
CP	1356	broad.mit.edu	37	chr3	148899820	148899820	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gttggagtaactgtagaactCtctgtttgtaccccatgggc	11	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:148899820C>G	ENST00000264613.6	-	14	2788	c.2526G>C	c.(2524-2526)gaG>gaC	p.E842D		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	842	F5/8 type A 3.|Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CTGTAGAACTCTCTGTTTGTA	0.468													11	88					0	0	1	0	0	G	148899820	C	G	148899820	3	3	37	1	0	0	0	0	1	0	0	0	3810	912	32	2	695	2	CP	3	148899820	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	15714046	148899820	49122610	86	3401										
MED12L	116931	broad.mit.edu	37	chr3	151095894	151095894	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgctgaaagccgctggggaaGagctggagaagggacagcac	17	8	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:151095894G>C	ENST00000474524.1	+	29	4344	c.4306G>C	c.(4306-4308)Gag>Cag	p.E1436Q	MED12L_ENST00000273432.4_Missense_Mutation_p.E1296Q|P2RY12_ENST00000302632.3_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1436					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CGCTGGGGAAGAGCTGGAGAA	0.537													6	58					0	0	1	0	0	C	151095894	G	C	151095894	3	2	37	1	0	0	0	0	1	0	0	0	9478	943	33	2	4420	2	MED12L	3	151095894	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2196074	151095894	46926536	87	3402										
ZMAT3	64393	broad.mit.edu	37	chr3	178785380	178785380	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agtcttgctcccctcccttcGataactcttcttcccctgca	4	18	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:178785380G>A	ENST00000311417.2	-	2	902	c.161C>T	c.(160-162)tCg>tTg	p.S54L	ZMAT3_ENST00000432729.1_Missense_Mutation_p.S54L	NM_022470.3	NP_071915.1	Q9HA38	ZMAT3_HUMAN	zinc finger, matrin-type 3	54					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(1)|skin(1)	14	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			CCCTCCCTTCGATAACTCTTC	0.552													15	76					0	0	1	0	0	A	178785380	G	A	178785380	3	1	37	1	0	0	0	0	1	0	0	0	17750	1059	37	1	728	1	ZMAT3	3	178785380	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	27689486	178785380	19237050	88	3403										
RTP2	344892	broad.mit.edu	37	chr3	187416648	187416648	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctcctccagcatgctggactCgtccagccgcgccgtgccgc	11	19	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:187416648C>T	ENST00000358241.1	-	2	744	c.316G>A	c.(316-318)Gag>Aag	p.E106K		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	106					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		ATGCTGGACTCGTCCAGCCGC	0.652													3	29					0	0	1	0	0	T	187416648	C	T	187416648	3	4	37	1	0	0	0	0	1	0	0	0	13785	893	31	1	365	1	RTP2	3	187416648	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	8631268	187416648	10605782	89	3404										
LRRC15	131578	broad.mit.edu	37	chr3	194080440	194080440	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aggtacagtgtccgtccctaAcctaggctggttgagcagga	13	10	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr3:194080440A>G	ENST00000347624.3	-	2	1418	c.1333T>C	c.(1333-1335)Tta>Cta	p.L445L	LRRC15_ENST00000428839.1_Silent_p.L451L|LRRC15_ENST00000439944.2_Silent_p.L451L	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	445	LRRCT.					integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TCCGTCCCTAACCTAGGCTGG	0.552													4	38					0	0	1	0	0	G	194080440	A	G	194080440	2	3	37	1	0	0	0	0	0	0	0	1	9014	40	2	4		4	LRRC15	3	194080440	Silent	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	6663792	194080440	3941990	90	3405										
SPON2	10417	broad.mit.edu	37	chr4	1165191	1165191	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cttcatcagcgcccaggcctCgccgcgctccgcaaagtcgc	10	19	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:1165191C>G	ENST00000290902.5	-	3	636	c.304G>C	c.(304-306)Gag>Cag	p.E102Q	SPON2_ENST00000431380.1_Missense_Mutation_p.E102Q	NM_012445.3	NP_036577.1	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	102	Spondin.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|pancreas(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		GCCCAGGCCTCGCCGCGCTCC	0.701													7	38					0	0	1	0	0	G	1165191	C	G	1165191	3	3	37	1	0	0	0	0	1	0	0	0	15138	893	31	2	707	2	SPON2	4	1165191	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08		1165191	189989085	91	3406										
MAEA	10296	broad.mit.edu	37	chr4	1332269	1332269	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctgccctgtgtgcagccgctCcctgaacaagctggcgcagc	12	16	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:1332269C>T	ENST00000303400.4	+	8	1022	c.959C>T	c.(958-960)tCc>tTc	p.S320F	MAEA_ENST00000512289.1_3'UTR|MAEA_ENST00000264750.6_Missense_Mutation_p.S279F|MAEA_ENST00000452175.2_Missense_Mutation_p.S241F|MAEA_ENST00000514708.1_Missense_Mutation_p.S252F|MAEA_ENST00000510794.1_Missense_Mutation_p.S319F|MAEA_ENST00000505839.1_Missense_Mutation_p.S272F|MAEA_ENST00000505177.2_Missense_Mutation_p.S358F	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher	320					cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			TGCAGCCGCTCCCTGAACAAG	0.632													9	43					0	0	1	0	0	T	1332269	C	T	1332269	3	4	37	1	0	0	0	0	1	0	0	0	9198	855	30	3	989	3	MAEA	4	1332269	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	167078	1332269	189822007	92	3407										
RGS12	6002	broad.mit.edu	37	chr4	3318236	3318236	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agtgatgaagaagggggactCtatgaaggaaaaggctggct	16	4	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:3318236C>T	ENST00000336727.3	+	2	1243	c.339C>T	c.(337-339)ctC>ctT	p.L113L	RGS12_ENST00000344733.5_Silent_p.L113L|RGS12_ENST00000543385.1_Silent_p.L113L|RGS12_ENST00000382788.3_Silent_p.L113L	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	113						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAGGGGGACTCTATGAAGGAA	0.488													4	71					0	0	1	0	0	T	3318236	C	T	3318236	2	4	37	1	0	0	0	0	0	0	0	1	13344	900	32	3		3	RGS12	4	3318236	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1985967	3318236	187836040	93	3408										
RFC1	5981	broad.mit.edu	37	chr4	39304134	39304134	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atttacctgtctgatatcttGattggctcccaaaattattt	5	8	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:39304134G>A	ENST00000381897.1	-	18	2558	c.2425C>T	c.(2425-2427)Caa>Taa	p.Q809*	RFC1_ENST00000349703.2_Nonsense_Mutation_p.Q808*	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	809					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						CTGATATCTTGATTGGCTCCC	0.353													4	33					0	0	1	0	0	A	39304134	G	A	39304134	4	1	37	1	0	0	0	0	0	1	0	0	13295	1299	45	3	1053	3	RFC1	4	39304134	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	35985898	39304134	151850142	94	3409										
GABRA2	2555	broad.mit.edu	37	chr4	46252592	46252592	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gccactgcataagcgttgttCtgtatcataacggaagcctt	9	10	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:46252592C>T	ENST00000510861.1	-	10	1262	c.1089G>A	c.(1087-1089)caG>caA	p.Q363Q	GABRA2_ENST00000381620.4_Silent_p.Q363Q|GABRA2_ENST00000540012.1_Silent_p.Q368Q|GABRA2_ENST00000514090.1_Silent_p.Q363Q|GABRA2_ENST00000356504.1_Silent_p.Q363Q|GABRA2_ENST00000507069.1_Silent_p.Q423Q			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	363					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAGCGTTGTTCTGTATCATAA	0.408													10	83					0	0	1	0	0	T	46252592	C	T	46252592	2	4	37	1	0	0	0	0	0	0	0	1	6195	912	32	3		3	GABRA2	4	46252592	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6948458	46252592	144901684	95	3410										
GABRA4	2557	broad.mit.edu	37	chr4	46930400	46930400	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggtggagccgatggaggagGagtagctgacaacttcccag	16	8	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:46930400G>C	ENST00000264318.3	-	9	2489	c.1507C>G	c.(1507-1509)Cct>Gct	p.P503A		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	503					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GATGGAGGAGGAGTAGCTGAC	0.463													8	114					0	0	1	0	0	C	46930400	G	C	46930400	3	2	37	1	0	0	0	0	1	0	0	0	6197	1174	41	2	161	2	GABRA4	4	46930400	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	677808	46930400	144223876	96	3411										
CCNI	10983	broad.mit.edu	37	chr4	77969711	77969711	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caggtcaccagggtgtgcttGaggggacggtagacataaac	15	8	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:77969711G>A	ENST00000237654.4	-	7	1371	c.795C>T	c.(793-795)ctC>ctT	p.L265L	CCNI_ENST00000537948.1_Silent_p.L251L	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	265					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						GGGTGTGCTTGAGGGGACGGT	0.527													11	82					0	0	1	0	0	A	77969711	G	A	77969711	2	1	37	1	0	0	0	0	0	0	0	1	2948	1277	45	3		3	CCNI	4	77969711	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	31039311	77969711	113184565	97	3412										
WDFY3	23001	broad.mit.edu	37	chr4	85642692	85642692	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	catctcctccatcaggtgcaGatcgggagcgttttagagga	12	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:85642692G>C	ENST00000322366.6	-	46	7831	c.7424C>G	c.(7423-7425)tCt>tGt	p.S2475C	WDFY3_ENST00000295888.4_Missense_Mutation_p.S2492C			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2492						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATCAGGTGCAGATCGGGAGCG	0.498													10	58					0	0	1	0	0	C	85642692	G	C	85642692	3	2	37	1	0	0	0	0	1	0	0	0	17329	942	33	2	3193	2	WDFY3	4	85642692	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	7672981	85642692	105511584	98	3413										
PTPN13	0	broad.mit.edu	37	chr4	87724875	87724875	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctattagatcattcctttctGacaaacgatgagctcgctgt	7	10	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:87724875G>C	ENST00000436978.1	+	43	7014	c.6534G>C	c.(6532-6534)ctG>ctC	p.L2178L	PTPN13_ENST00000316707.6_Silent_p.L1982L|PTPN13_ENST00000427191.2_Silent_p.L2154L|PTPN13_ENST00000411767.2_Silent_p.L2173L|PTPN13_ENST00000511467.1_Silent_p.L2178L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2173						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ATTCCTTTCTGACAAACGATG	0.423													8	82					0	0	1	0	0	C	87724875	G	C	87724875	2	2	37	1	0	0	0	0	0	0	0	1	12831	1277	45	2		2	PTPN13	4	87724875	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2082183	87724875	103429401	99	3414										
QRFPR	84109	broad.mit.edu	37	chr4	122250697	122250697	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccatgcctttgtgctggagaGaaggttttatttactatgca	10	7	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:122250697G>C	ENST00000394427.2	-	6	1479	c.1068C>G	c.(1066-1068)ttC>ttG	p.F356L	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	356						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						GTGCTGGAGAGAAGGTTTTAT	0.373													8	69					0	0	1	0	0	C	122250697	G	C	122250697	3	2	37	1	0	0	0	0	1	0	0	0	12929	933	33	2	231	2	QRFPR	4	122250697	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	34525822	122250697	68903579	100	3415										
TMEM155	132332	broad.mit.edu	37	chr4	122682819	122682819	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tattctgtagaatcgcaccaGatggcatcagttctgcatct	8	10	4	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:122682819G>C	ENST00000337677.5	-	5	644	c.86C>G	c.(85-87)tCt>tGt	p.S29C	TMEM155_ENST00000394396.1_Missense_Mutation_p.S29C|TMEM155_ENST00000394394.1_Missense_Mutation_p.S29C	NM_152399.2	NP_689612.2	Q4W5P6	TM155_HUMAN	transmembrane protein 155	29						extracellular region				breast(1)|lung(5)	6						AATCGCACCAGATGGCATCAG	0.423													9	32					0	0	1	0	0	C	122682819	G	C	122682819	3	2	37	1	0	0	0	0	1	0	0	0	16131	942	33	2	314	2	TMEM155	4	122682819	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	432122	122682819	68471457	101	3416										
HSPA4L	22824	broad.mit.edu	37	chr4	128741618	128741618	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aaacaagaccgattaaatcaGacacttaaaaaaggaaaagt	6	6	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:128741618G>C	ENST00000296464.3	+	14	2121	c.1710G>C	c.(1708-1710)caG>caC	p.Q570H	HSPA4L_ENST00000439123.2_Missense_Mutation_p.Q601H|HSPA4L_ENST00000508776.1_Missense_Mutation_p.Q570H|HSPA4L_ENST00000515262.1_3'UTR|HSPA4L_ENST00000505726.1_Missense_Mutation_p.Q544H	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	570					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GATTAAATCAGACACTTAAAA	0.338													6	21					0	0	1	0	0	C	128741618	G	C	128741618	3	2	37	1	0	0	0	0	1	0	0	0	7455	933	33	2	1764	2	HSPA4L	4	128741618	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6058799	128741618	62412658	102	3417										
TBC1D9	23158	broad.mit.edu	37	chr4	141600123	141600123	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gagcagacacttttttaggaGatttccttttgagtttgggc	11	6	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:141600123G>A	ENST00000442267.2	-	5	898	c.824C>T	c.(823-825)tCt>tTt	p.S275F		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	275						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTTTTTAGGAGATTTCCTTTT	0.403													13	118					0	0	1	0	0	A	141600123	G	A	141600123	3	1	37	1	0	0	0	0	1	0	0	0	15686	942	33	3	3044	3	TBC1D9	4	141600123	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	12858505	141600123	49554153	103	3418										
SMARCA5	8467	broad.mit.edu	37	chr4	144445612	144445612	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttgcactcgatttgaagactCtccatcgtgtatgttaaaca	7	9	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:144445612C>G	ENST00000283131.3	+	4	974	c.512C>G	c.(511-513)tCt>tGt	p.S171C		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	171					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding		EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					TTTGAAGACTCTCCATCGTGT	0.378													5	41					0	0	1	0	0	G	144445612	C	G	144445612	3	3	37	1	0	0	0	0	1	0	0	0	14824	913	32	2	526	2	SMARCA5	4	144445612	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2845489	144445612	46708664	104	3419										
HHIP	64399	broad.mit.edu	37	chr4	145567979	145567979	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccgaagcgcctgaaaaggaGagacaggaggatgatgtccc	14	10	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:145567979G>C	ENST00000296575.3	+	1	807	c.152G>C	c.(151-153)aGa>aCa	p.R51T	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.R51T	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	51	Arg-rich.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CTGAAAAGGAGAGACAGGAGG	0.582													6	43					0	0	1	0	0	C	145567979	G	C	145567979	3	2	37	1	0	0	0	0	1	0	0	0	7132	942	33	2	154	2	HHIP	4	145567979	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1122367	145567979	45586297	105	3420										
FBXW7	0	broad.mit.edu	37	chr4	153249385	153249385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcatgaagatgcatacaacGcacagtggaagtatgcccat	9	9	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:153249385G>A	ENST00000281708.4	-	9	2622	c.1393C>T	c.(1393-1395)Cgt>Tgt	p.R465C	FBXW7_ENST00000296555.5_Missense_Mutation_p.R347C|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385C|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289C|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465C|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465C	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465C(71)|p.R226C(11)|p.R385C(11)|p.R347C(3)|p.R465Y(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCATACAACGCACAGTGGAA	0.413			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								51	72					0	0	1	0	0	A	153249385	G	A	153249385	3	1	37	1	0	0	0	0	1	0	0	0	5801	1087	38	1	746	1	FBXW7	4	153249385	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	7681406	153249385	37904891	106	3421										
TLR2	7097	broad.mit.edu	37	chr4	154626043	154626043	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggagaaccttatggtccagGagctggagaacttcaatccc	11	10	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:154626043G>C	ENST00000260010.6	+	1	3392	c.1984G>C	c.(1984-1986)Gag>Cag	p.E662Q		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	662	TIR.				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TATGGTCCAGGAGCTGGAGAA	0.473													10	60					0	0	1	0	0	C	154626043	G	C	154626043	3	2	37	1	0	0	0	0	1	0	0	0	16010	1175	41	2	1986	2	TLR2	4	154626043	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1376658	154626043	36528233	107	3422										
AGA	175	broad.mit.edu	37	chr4	178360736	178360736	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agttaaaaaaatacctgactCtcctactaaaagtgtgtgtg	7	7	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr4:178360736C>G	ENST00000264595.2	-	3	515	c.388G>C	c.(388-390)Gag>Cag	p.E130Q	AGA_ENST00000506853.1_5'UTR	NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	130					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		ATACCTGACTCTCCTACTAAA	0.343													14	70					0	0	1	0	0	G	178360736	C	G	178360736	3	3	37	1	0	0	0	0	1	0	0	0	364	922	32	2	680	2	AGA	4	178360736	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	23734693	178360736	12793540	108	3423										
C5orf38	153571	broad.mit.edu	37	chr5	2755234	2755234	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcgaggaacagccggccccgGaggctcgggctcggggtctc	18	14	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:2755234G>C	ENST00000397835.4	+	3	425	c.425G>C	c.(424-426)gGa>gCa	p.G142A	C5orf38_ENST00000334000.3_3'UTR			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	0						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		GCCGGCCCCGGAGGCTCGGGC	0.701													7	63					0	0	1	0	0	C	2755234	G	C	2755234	3	2	37	1	0	0	0	0	1	0	0	0	2311	1189	41	2		2	C5orf38	5	2755234	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		2755234	178160026	109	3424										
ADAMTS16	170690	broad.mit.edu	37	chr5	5306709	5306709	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatcgagagctggcctcaaaGaagtgctcacatttgccgaa	10	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:5306709G>A	ENST00000274181.7	+	21	3417	c.3279G>A	c.(3277-3279)aaG>aaA	p.K1093K		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	1093	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TGGCCTCAAAGAAGTGCTCAC	0.522													8	52					0	0	1	0	0	A	5306709	G	A	5306709	2	1	37	1	0	0	0	0	0	0	0	1	260	933	33	3		3	ADAMTS16	5	5306709	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2551475	5306709	175608551	110	3425										
ADCY2	108	broad.mit.edu	37	chr5	7695897	7695897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgacatcgttggctttacccGgctggcaagtgactgctccc	11	13	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:7695897G>A	ENST00000338316.4	+	6	991	c.902G>A	c.(901-903)cGg>cAg	p.R301Q	ADCY2_ENST00000537121.1_Missense_Mutation_p.R121Q	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	301					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGCTTTACCCGGCTGGCAAGT	0.413													17	26					0	0	1	0	0	A	7695897	G	A	7695897	3	1	37	1	0	0	0	0	1	0	0	0	293	1116	39	1	924	1	ADCY2	5	7695897	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2389188	7695897	173219363	111	3426										
DNAH5	1767	broad.mit.edu	37	chr5	13753449	13753449	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgtgacaataattccattttGaatggacaagtcatcatttg	7	7	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:13753449G>C	ENST00000265104.4	-	63	10869	c.10765C>G	c.(10765-10767)Caa>Gaa	p.Q3589E		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3589	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATTCCATTTTGAATGGACAAG	0.383									Kartagener syndrome				11	57					0	0	1	0	0	C	13753449	G	C	13753449	3	2	37	1	0	0	0	0	1	0	0	0	4632	1299	45	2	3177	2	DNAH5	5	13753449	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6057552	13753449	167161811	112	3427										
TRIM23	373	broad.mit.edu	37	chr5	64913964	64913964	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atgggcaacggattgctcttCcatgaagaggtaggcgagtg	15	7	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:64913964C>T	ENST00000231524.9	-	2	571	c.200G>A	c.(199-201)gGa>gAa	p.G67E	TRIM23_ENST00000381018.3_Missense_Mutation_p.G67E|TRIM23_ENST00000274327.7_Missense_Mutation_p.G67E	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	67					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		GATTGCTCTTCCATGAAGAGG	0.413													4	55					0	0	1	0	0	T	64913964	C	T	64913964	3	4	37	1	0	0	0	0	1	0	0	0	16557	855	30	3	1631	3	TRIM23	5	64913964	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	51160515	64913964	116001296	113	3428										
IQGAP2	10788	broad.mit.edu	37	chr5	75996926	75996926	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctcggagatcaattaaactaGatggaaaaggagaacccaaa	9	7	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:75996926G>C	ENST00000274364.6	+	34	4690	c.4393G>C	c.(4393-4395)Gat>Cat	p.D1465H	IQGAP2_ENST00000502745.1_Missense_Mutation_p.D961H|IQGAP2_ENST00000396234.3_Missense_Mutation_p.D961H|IQGAP2_ENST00000379730.3_Missense_Mutation_p.D967H|CTD-2384B11.2_ENST00000507514.1_RNA	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1465					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AATTAAACTAGATGGAAAAGG	0.423													9	46					0	0	1	0	0	C	75996926	G	C	75996926	3	2	37	1	0	0	0	0	1	0	0	0	7858	942	33	2	4527	2	IQGAP2	5	75996926	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	11082962	75996926	104918334	114	3429										
PJA2	9867	broad.mit.edu	37	chr5	108704338	108704338	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tagctcaggttcattctcatCttttcctggcagagtctccc	7	13	5	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:108704338C>A	ENST00000361189.2	-	5	1632	c.1393G>T	c.(1393-1395)Gat>Tat	p.D465Y	PJA2_ENST00000361557.3_Missense_Mutation_p.D465Y	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	465					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		TCATTCTCATCTTTTCCTGGC	0.423													15	53					7.93312e-07	8.41685e-07	1	1	0	A	108704338	C	A	108704338	3	1	37	1	0	0	0	0	1	0	0	0	12009	913	32	2	757	2	PJA2	5	108704338	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	32707412	108704338	72210922	115	3430										
SEMA6A	57556	broad.mit.edu	37	chr5	115782673	115782673	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatagtcaaccccgtaggaaGaggagtggtgcatttccagc	12	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:115782673G>A	ENST00000343348.6	-	19	3516	c.2729C>T	c.(2728-2730)tCt>tTt	p.S910F	SEMA6A_ENST00000282394.6_Missense_Mutation_p.S387F|SEMA6A_ENST00000510263.1_Missense_Mutation_p.S910F|SEMA6A_ENST00000257414.8_Missense_Mutation_p.S927F|SEMA6A_ENST00000503865.1_Missense_Mutation_p.S289F|SEMA6A_ENST00000513137.1_Missense_Mutation_p.S337F	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	910					apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CCCGTAGGAAGAGGAGTGGTG	0.587													8	77					0	0	1	0	0	A	115782673	G	A	115782673	3	1	37	1	0	0	0	0	1	0	0	0	14092	942	33	3	367	3	SEMA6A	5	115782673	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	7078335	115782673	65132587	116	3431										
FNIP1	96459	broad.mit.edu	37	chr5	131006169	131006169	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cactcacctgcacagcatgaGataaatctgacatcagacac	6	13	3	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:131006169G>C	ENST00000307968.7	-	14	3010	c.3011C>G	c.(3010-3012)tCt>tGt	p.S1004C	FNIP1_ENST00000307954.8_Missense_Mutation_p.S987C|FNIP1_ENST00000510461.1_Missense_Mutation_p.S1032C|FNIP1_ENST00000514667.1_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		CACAGCATGAGATAAATCTGA	0.418													17	89					0	0	1	0	0	C	131006169	G	C	131006169	3	2	37	1	0	0	0	0	1	0	0	0	6007	942	33	2	421	2	FNIP1	5	131006169	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	15223496	131006169	49909091	117	3432										
FAM53C	51307	broad.mit.edu	37	chr5	137682488	137682488	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctgtagccccccacccctctCtgcttcctgcagccccactg	6	22	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:137682488C>G	ENST00000239906.5	+	5	1447	c.1019C>G	c.(1018-1020)tCt>tGt	p.S340C	FAM53C_ENST00000513056.1_3'UTR|FAM53C_ENST00000434981.2_Missense_Mutation_p.S340C	NM_016605.2	NP_057689.1	Q9NYF3	FA53C_HUMAN	family with sequence similarity 53, member C	340										breast(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCACCCCTCTCTGCTTCCTGC	0.622													9	61					0	0	1	0	0	G	137682488	C	G	137682488	3	3	37	1	0	0	0	0	1	0	0	0	5616	913	32	2	1033	2	FAM53C	5	137682488	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6676319	137682488	43232772	118	3433										
PCDHA3	0	broad.mit.edu	37	chr5	140182485	140182485	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgcgccggcactgctgatgcCtcgggtgggtggcatcggtg	18	12	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:140182485C>A	ENST00000522353.2	+	1	1703	c.1703C>A	c.(1702-1704)cCt>cAt	p.P568H	PCDHA3_ENST00000532566.2_Missense_Mutation_p.P568H|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTGATGCCTCGGGTGGGT	0.687													21	153					1.37657e-19	1.51981e-19	1	1	0	A	140182485	C	A	140182485	3	1	37	1	0	0	0	0	1	0	0	0	11571	681	24	5	1705	5	PCDHA3	5	140182485	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2499997	140182485	40732775	119	3434										
SLU7	10569	broad.mit.edu	37	chr5	159830471	159830471	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggcctcctctgcgttcagtgCctatagtgagaggaataaaa	11	9	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:159830471C>T	ENST00000297151.4	-	16	1969	c.1581_splice	c.e16-1	p.A528_splice		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	528					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCGTTCAGTGCCTATAGTGAG	0.458													58	72					0	0	1	0	0	T	159830471	C	T	159830471	5	4	37	1	0	0	0	0	0	0	1	0	14808	753	26	3	182	3	SLU7	5	159830471	Splice_Site	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	19647986	159830471	21084789	120	3435										
STK10	6793	broad.mit.edu	37	chr5	171533727	171533727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cggctcgatctgggccatctCaatcagcgtgatgcccaggg	13	13	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:171533727C>G	ENST00000176763.5	-	6	1028	c.685G>C	c.(685-687)Gag>Cag	p.E229Q		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	229	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGCCATCTCAATCAGCGTG	0.597											OREG0017039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	63					0	0	1	0	0	G	171533727	C	G	171533727	3	3	37	1	0	0	0	0	1	0	0	0	15341	835	29	2	2277	2	STK10	5	171533727	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	11703256	171533727	9381533	121	3436										
FGFR4	2264	broad.mit.edu	37	chr5	176519359	176519359	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccatcctgcaggccgggctCccggccaacaccacagccgt	10	20	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:176519359C>T	ENST00000292408.4	+	7	1010	c.765C>T	c.(763-765)ctC>ctT	p.L255L	FGFR4_ENST00000292410.3_Silent_p.L255L|FGFR4_ENST00000393637.1_Silent_p.L255L|FGFR4_ENST00000393648.2_Silent_p.L255L|FGFR4_ENST00000502906.1_Silent_p.L255L	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	255	Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	AGGCCGGGCTCCCGGCCAACA	0.667										TSP Lung(9;0.080)			7	24					0	0	1	0	0	T	176519359	C	T	176519359	2	4	37	1	0	0	0	0	0	0	0	1	5900	842	30	3		3	FGFR4	5	176519359	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4985632	176519359	4395901	122	3437										
BTNL8	79908	broad.mit.edu	37	chr5	180374588	180374588	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgctgtggcctattttttggCattgttggactgaagatttt	11	5	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr5:180374588C>T	ENST00000231229.4	+	4	984	c.750C>T	c.(748-750)ggC>ggT	p.G250G	BTNL8_ENST00000400707.3_Silent_p.G125G|BTNL8_ENST00000505126.1_Silent_p.G43G|BTNL8_ENST00000508408.1_Silent_p.G250G|BTNL8_ENST00000533815.2_Silent_p.G66G|BTNL8_ENST00000340184.4_Silent_p.G250G|BTNL8_ENST00000511704.1_Silent_p.G134G	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	250						integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TATTTTTTGGCATTGTTGGAC	0.463													29	223					0	0	1	0	0	T	180374588	C	T	180374588	2	4	37	1	0	0	0	0	0	0	0	1	1570	697	25	3		3	BTNL8	5	180374588	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3855229	180374588	540672	123	3438										
DSP	1832	broad.mit.edu	37	chr6	7571654	7571654	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gaagattacatgaagacgatAgccgaccttgagttacatta	9	7	0	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:7571654A>T	ENST00000379802.3	+	14	2081	c.1740A>T	c.(1738-1740)atA>atT	p.I580I	DSP_ENST00000418664.2_Silent_p.I580I	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	580	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGAAGACGATAGCCGACCTTG	0.443													27	261					0	0	1	0	0	T	7571654	A	T	7571654	2	4	37	1	0	0	0	0	0	0	0	1	4807	410	15	4		4	DSP	6	7571654	Silent	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08		7571654	163543413	124	3439										
ALDH5A1	7915	broad.mit.edu	37	chr6	24515420	24515420	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aagccaggctgggattccttCaggtgtatacaatgttattc	10	8	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:24515420C>T	ENST00000357578.3	+	5	897	c.752C>T	c.(751-753)tCa>tTa	p.S251L	ALDH5A1_ENST00000348925.2_Missense_Mutation_p.S264L|ALDH5A1_ENST00000491546.1_Missense_Mutation_p.S223L|ALDH5A1_ENST00000546278.1_Missense_Mutation_p.S163L	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	251					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	GGGATTCCTTCAGGTGTATAC	0.378													6	68					0	0	1	0	0	T	24515420	C	T	24515420	3	4	37	1	0	0	0	0	1	0	0	0	499	838	29	3	813	3	ALDH5A1	6	24515420	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	16943766	24515420	146599647	125	3440										
HIST1H2AK	8330	broad.mit.edu	37	chr6	27805761	27805761	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttgtggtggctctcagttttCttaggcagcagcacggcctg	13	10	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:27805761C>T	ENST00000330180.2	-	1	356	c.357G>A	c.(355-357)aaG>aaA	p.K119K		NM_003510.2	NP_003501.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	119					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(2)|endometrium(2)|kidney(1)|lung(3)|upper_aerodigestive_tract(2)	10						TCTCAGTTTTCTTAGGCAGCA	0.552													10	156					0	0	1	0	0	T	27805761	C	T	27805761	2	4	37	1	0	0	0	0	0	0	0	1	7177	912	32	3		3	HIST1H2AK	6	27805761	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3290341	27805761	143309306	126	3441										
MUC21	394263	broad.mit.edu	37	chr6	30955308	30955308	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggctctggaacagcagctctGactggaatgcacacaacttc	10	12	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:30955308G>A	ENST00000376296.3	+	2	1597	c.1356G>A	c.(1354-1356)ctG>ctA	p.L452L	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	452						integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CAGCAGCTCTGACTGGAATGC	0.577													8	160					0	0	1	0	0	A	30955308	G	A	30955308	2	1	37	1	0	0	0	0	0	0	0	1	10024	1277	45	3		3	MUC21	6	30955308	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	3149547	30955308	140159759	127	3442										
TNXB	7148	broad.mit.edu	37	chr6	32063827	32063827	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caacagatgcacacaccgtcCtggcacacgccgtgctggct	10	16	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:32063827C>A	ENST00000375244.3	-	3	2004	c.1803G>T	c.(1801-1803)caG>caT	p.Q601H	TNXB_ENST00000479795.1_Missense_Mutation_p.Q601H|TNXB_ENST00000375247.2_Missense_Mutation_p.Q601H			P22105	TENX_HUMAN	tenascin XB	601	EGF-like 15.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACACACCGTCCTGGCACACGC	0.647													8	55					5.18039e-06	5.43005e-06	1	1	0	A	32063827	C	A	32063827	3	1	37	1	0	0	0	0	1	0	0	0	16405	680	24	5	13078	5	TNXB	6	32063827	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1108519	32063827	139051240	128	3443										
PRRT1	80863	broad.mit.edu	37	chr6	32117019	32117019	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttagggatcccagtagttctCgtggtgctgcgcggcgatga	15	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:32117019C>T	ENST00000211413.5	-	4	1025	c.901G>A	c.(901-903)Gag>Aag	p.E301K	PRRT1_ENST00000467780.1_5'UTR|PRRT1_ENST00000375152.2_Missense_Mutation_p.E220K|PRRT1_ENST00000375150.2_Missense_Mutation_p.E220K	NM_030651.3	NP_085154.3	Q99946	PRRT1_HUMAN	proline-rich transmembrane protein 1	301					response to biotic stimulus	integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						CAGTAGTTCTCGTGGTGCTGC	0.627													11	30					0	0	1	0	0	T	32117019	C	T	32117019	3	4	37	1	0	0	0	0	1	0	0	0	12658	893	31	1	23	1	PRRT1	6	32117019	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	53192	32117019	138998048	129	3444										
CAPN11	11131	broad.mit.edu	37	chr6	44144372	44144372	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagatgcagctgctgcacaaGacggaggacggggagttctg	16	9	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:44144372G>C	ENST00000542245.1	+	10	1094	c.1056G>C	c.(1054-1056)aaG>aaC	p.K352N	CAPN11_ENST00000398776.1_Missense_Mutation_p.K352N			Q9UMQ6	CAN11_HUMAN	calpain 11	352	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCTGCACAAGACGGAGGACG	0.627													11	68					0	0	1	0	0	C	44144372	G	C	44144372	3	2	37	1	0	0	0	0	1	0	0	0	2642	933	33	2	1094	2	CAPN11	6	44144372	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	12027353	44144372	126970695	130	3445										
SLC35B2	347734	broad.mit.edu	37	chr6	44224543	44224543	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	catagctgggtccatgactcCggaggggcttcgggagtctc	15	11	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:44224543C>A	ENST00000393812.3	-	2	227	c.84G>T	c.(82-84)ccG>ccT	p.P28P	SLC35B2_ENST00000537814.1_Intron|SLC35B2_ENST00000538577.1_5'UTR|SLC35B2_ENST00000495706.1_Intron|SLC35B2_ENST00000393810.1_Silent_p.P28P	NM_178148.2	NP_835361.1	Q8TB61	S35B2_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2	28					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	15	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCATGACTCCGGAGGGGCTT	0.577													18	109					6.94344e-10	7.55099e-10	1	1	0	A	44224543	C	A	44224543	2	1	37	1	0	0	0	0	0	0	0	1	14630	639	23	5		5	SLC35B2	6	44224543	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	80171	44224543	126890524	131	3446										
EEF1A1	1915	broad.mit.edu	37	chr6	74229640	74229640	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tctcaaatttttcaatggttCttttgtcgatgccaccgcat	6	10	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:74229640C>T	ENST00000316292.9	-	1	1101	c.110G>A	c.(109-111)aGa>aAa	p.R37K	EEF1A1_ENST00000331523.2_Missense_Mutation_p.R37K|EEF1A1_ENST00000309268.6_Missense_Mutation_p.R37K	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	37						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						TTCAATGGTTCTTTTGTCGAT	0.408													5	60					0	0	1	0	0	T	74229640	C	T	74229640	3	4	37	1	0	0	0	0	1	0	0	0	4949	913	32	3	1306	3	EEF1A1	6	74229640	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	30005097	74229640	96885427	132	3447										
CNR1	0	broad.mit.edu	37	chr6	88854953	88854953	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggaggtcagtggtgatggtgCggaaggtggtatctgcaagg	20	4	2	1	rs142010122		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:88854953C>A	ENST00000537554.1	-	2	3603	c.41G>T	c.(40-42)cGc>cTc	p.R14L	CNR1_ENST00000369499.2_Missense_Mutation_p.R14L|CNR1_ENST00000549890.1_Missense_Mutation_p.R14L|CNR1_ENST00000535130.1_Missense_Mutation_p.R14L|CNR1_ENST00000428600.2_Missense_Mutation_p.R14L|CNR1_ENST00000549716.1_Missense_Mutation_p.A9S|CNR1_ENST00000362094.5_Missense_Mutation_p.R14L|CNR1_ENST00000369501.2_Missense_Mutation_p.R14L|CNR1_ENST00000468898.1_Missense_Mutation_p.R14L	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	14					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GGTGATGGTGCGGAAGGTGGT	0.483													11	118					3.07112e-06	3.2269e-06	1	1	0	A	88854953	C	A	88854953	3	1	37	1	0	0	0	0	1	0	0	0	3654	768	27	5	1381	5	CNR1	6	88854953	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	14625313	88854953	82260114	133	3448										
MDN1	23195	broad.mit.edu	37	chr6	90371187	90371187	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcggtgtcctcaccaccattCttgtcttcactgtcgaggtt	8	13	4	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:90371187C>T	ENST00000369393.3	-	88	14791	c.14676G>A	c.(14674-14676)aaG>aaA	p.K4892K	MDN1_ENST00000428876.1_Silent_p.K4892K			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	4892					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CACCACCATTCTTGTCTTCAC	0.458													7	101					0	0	1	0	0	T	90371187	C	T	90371187	2	4	37	1	0	0	0	0	0	0	0	1	9464	912	32	3		3	MDN1	6	90371187	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1516234	90371187	80743880	134	3449										
L3MBTL3	84456	broad.mit.edu	37	chr6	130392265	130392265	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acaactgggatgagagctatGactattggtgagacattttc	11	6	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:130392265G>A	ENST00000529410.1	+	15	1716	c.1237G>A	c.(1237-1239)Gac>Aac	p.D413N	L3MBTL3_ENST00000533560.1_Missense_Mutation_p.D388N|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.D388N|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.D413N|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.D388N|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.D413N			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	413					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TGAGAGCTATGACTATTGGTG	0.343													16	135					0	0	1	0	0	A	130392265	G	A	130392265	3	1	37	1	0	0	0	0	1	0	0	0	8631	1290	45	3	1279	3	L3MBTL3	6	130392265	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	40021078	130392265	40722802	135	3450										
EPB41L2	2037	broad.mit.edu	37	chr6	131179290	131179290	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccttacttaatcttccccttCctcagccaactctgtttctt	2	16	4	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:131179290C>G	ENST00000337057.3	-	19	3185	c.3004G>C	c.(3004-3006)Gaa>Caa	p.E1002Q	EPB41L2_ENST00000525193.1_Missense_Mutation_p.E703Q|EPB41L2_ENST00000527659.1_Missense_Mutation_p.E808Q|EPB41L2_ENST00000392427.3_Missense_Mutation_p.E670Q|EPB41L2_ENST00000527411.1_Missense_Mutation_p.E932Q|EPB41L2_ENST00000525271.1_Missense_Mutation_p.E670Q|EPB41L2_ENST00000530757.1_Missense_Mutation_p.E198Q|EPB41L2_ENST00000530481.1_Missense_Mutation_p.E849Q|EPB41L2_ENST00000524581.1_Missense_Mutation_p.E380Q|EPB41L2_ENST00000529208.1_Missense_Mutation_p.E932Q|EPB41L2_ENST00000445890.2_Missense_Mutation_p.E744Q|EPB41L2_ENST00000368128.2_Missense_Mutation_p.E1002Q|EPB41L2_ENST00000531410.1_Missense_Mutation_p.E123Q|EPB41L2_ENST00000528282.1_Missense_Mutation_p.E744Q	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	1002	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TCTTCCCCTTCCTCAGCCAAC	0.502													21	148					0	0	1	0	0	G	131179290	C	G	131179290	3	3	37	1	0	0	0	0	1	0	0	0	5181	864	30	2	17	2	EPB41L2	6	131179290	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	787025	131179290	39935777	136	3451										
VNN2	8875	broad.mit.edu	37	chr6	133072608	133072608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agttttcccaactctgtcttCatgtcataatgatacacttt	4	10	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr6:133072608C>T	ENST00000326499.6	-	5	1000	c.876G>A	c.(874-876)atG>atA	p.M292I	VNN2_ENST00000525270.1_Missense_Mutation_p.M239I|VNN2_ENST00000525289.1_Intron	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	292	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		ACTCTGTCTTCATGTCATAAT	0.428													14	69					0	0	1	0	0	T	133072608	C	T	133072608	3	4	37	1	0	0	0	0	1	0	0	0	17242	826	29	3	698	3	VNN2	6	133072608	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1893318	133072608	38042459	137	3452										
MAD1L1	8379	broad.mit.edu	37	chr7	2188795	2188795	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggccaggtctacctgctggtGacggcgctgttcttgtcctt	13	12	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:2188795G>A	ENST00000406869.1	-	11	1622	c.1065C>T	c.(1063-1065)gtC>gtT	p.V355V	MAD1L1_ENST00000265854.7_Silent_p.V355V|MAD1L1_ENST00000402746.1_Silent_p.V263V|MAD1L1_ENST00000399654.2_Silent_p.V355V			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	355					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		ACCTGCTGGTGACGGCGCTGT	0.582													5	45					0	0	1	0	0	A	2188795	G	A	2188795	2	1	37	1	0	0	0	0	0	0	0	1	9192	1277	45	3		3	MAD1L1	7	2188795	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		2188795	156949868	138	3453										
EIF3B	8662	broad.mit.edu	37	chr7	2395011	2395011	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cggcgacgcggacgagccctCcttcagcgaccccgaggact	13	17	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:2395011C>G	ENST00000360876.4	+	1	511	c.455C>G	c.(454-456)tCc>tGc	p.S152C	EIF3B_ENST00000397011.2_Missense_Mutation_p.S152C	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	152	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GACGAGCCCTCCTTCAGCGAC	0.756													3	15					0	0	1	0	0	G	2395011	C	G	2395011	3	3	37	1	0	0	0	0	1	0	0	0	5039	855	30	2	457	2	EIF3B	7	2395011	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	206216	2395011	156743652	139	3454										
SDK1	221935	broad.mit.edu	37	chr7	4050669	4050669	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcaccgtgagtggcctgactCcggctcgtacctatcaattc	9	14	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:4050669C>G	ENST00000404826.2	+	15	2342	c.2203C>G	c.(2203-2205)Ccg>Gcg	p.P735A	SDK1_ENST00000389531.3_Missense_Mutation_p.P735A	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	735	Fibronectin type-III 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGGCCTGACTCCGGCTCGTAC	0.572													4	45					0	0	1	0	0	G	4050669	C	G	4050669	3	3	37	1	0	0	0	0	1	0	0	0	14021	855	30	2	2261	2	SDK1	7	4050669	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1655658	4050669	155087994	140	3455										
RAC1	5879	broad.mit.edu	37	chr7	6431634	6431634	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gggatacagctggacaagaaGattatgacagattacgcccc	11	9	0	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:6431634G>C	ENST00000348035.4	+	3	400	c.187G>C	c.(187-189)Gat>Cat	p.D63H	RAC1_ENST00000488373.1_3'UTR|RAC1_ENST00000356142.4_Missense_Mutation_p.D63H	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	63			D -> G (in dbSNP:rs5831).		actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	TGGACAAGAAGATTATGACAG	0.393													38	59					0	0	1	0	0	C	6431634	G	C	6431634	3	2	37	1	0	0	0	0	1	0	0	0	13025	942	33	2	197	2	RAC1	7	6431634	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2380965	6431634	152707029	141	3456										
RAC1	5879	broad.mit.edu	37	chr7	6441993	6441993	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcgctcacacagcgaggcctCaagacagtgtttgacgaagc	12	12	2	2	rs61753123	byFrequency	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:6441993C>T	ENST00000348035.4	+	6	708	c.495C>T	c.(493-495)ctC>ctT	p.L165L	RAC1_ENST00000488373.1_3'UTR|RAC1_ENST00000356142.4_Silent_p.L184L	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	165					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	AGCGAGGCCTCAAGACAGTGT	0.547													7	92					0	0	1	0	0	T	6441993	C	T	6441993	2	4	37	1	0	0	0	0	0	0	0	1	13025	813	29	3		3	RAC1	7	6441993	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10359	6441993	152696670	142	3457										
MEOX2	4223	broad.mit.edu	37	chr7	15725701	15725701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctccagagtcgggctggagGcagaggctgtgccgagccgc	17	13	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:15725701G>A	ENST00000262041.5	-	1	736	c.327C>T	c.(325-327)tgC>tgT	p.C109C		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	109					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CGGGCTGGAGGCAGAGGCTGT	0.672													3	16					0	0	1	0	0	A	15725701	G	A	15725701	2	1	37	1	0	0	0	0	0	0	0	1	9523	1195	42	3		3	MEOX2	7	15725701	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	9283708	15725701	143412962	143	3458										
AGR3	155465	broad.mit.edu	37	chr7	16901059	16901059	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcaggtgataaattcttatCagtggtttcatgctagcagg	10	6	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:16901059C>G	ENST00000310398.2	-	6	386	c.316G>C	c.(316-318)Gat>Cat	p.D106H	AGR3_ENST00000402239.3_Missense_Mutation_p.D106H	NM_176813.3	NP_789783.1	Q8TD06	AGR3_HUMAN	anterior gradient 3	106						extracellular region				central_nervous_system(1)|kidney(8)|lung(2)|skin(1)|stomach(1)	13	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		AAATTCTTATCAGTGGTTTCA	0.318													5	53					0	0	1	0	0	G	16901059	C	G	16901059	3	3	37	1	0	0	0	0	1	0	0	0	393	826	29	2	196	2	AGR3	7	16901059	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1175358	16901059	142237604	144	3459										
TRA2A	29896	broad.mit.edu	37	chr7	23561449	23561449	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccgttggagattttgactgaGagcgagactcctaacaaaga	11	8	0	5			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:23561449G>C	ENST00000297071.4	-	2	263	c.47C>G	c.(46-48)tCt>tGt	p.S16C	TRA2A_ENST00000474586.1_5'UTR|TRA2A_ENST00000538367.1_5'UTR|TRA2A_ENST00000392502.4_5'UTR	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)	16					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						TTTTGACTGAGAGCGAGACTC	0.418													4	50					0	0	1	0	0	C	23561449	G	C	23561449	3	2	37	1	0	0	0	0	1	0	0	0	16493	942	33	2	829	2	TRA2A	7	23561449	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6660390	23561449	135577214	145	3460										
PLEKHA8	84725	broad.mit.edu	37	chr7	30088967	30088967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctaccgcactccaccaggatCacctcagctggccatgctca	7	18	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:30088967C>T	ENST00000449726.1	+	5	916	c.566C>T	c.(565-567)tCa>tTa	p.S189L	PLEKHA8_ENST00000258679.7_Missense_Mutation_p.S189L|PLEKHA8_ENST00000396257.2_Missense_Mutation_p.S189L|PLEKHA8_ENST00000396259.1_Missense_Mutation_p.S189L	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	189					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						CCACCAGGATCACCTCAGCTG	0.458													8	91					0	0	1	0	0	T	30088967	C	T	30088967	3	4	37	1	0	0	0	0	1	0	0	0	12109	838	29	3	584	3	PLEKHA8	7	30088967	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6527518	30088967	129049696	146	3461										
SFRP4	6424	broad.mit.edu	37	chr7	37951728	37951728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tctttgtgcctaccttgagcGccactcgtaacacatgatga	8	12	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:37951728G>A	ENST00000436072.2	-	4	1161	c.784C>T	c.(784-786)Cgc>Tgc	p.R262C	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	262	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TACCTTGAGCGCCACTCGTAA	0.443													7	61					0	0	1	0	0	A	37951728	G	A	37951728	3	1	37	1	0	0	0	0	1	0	0	0	14216	1087	38	1	268	1	SFRP4	7	37951728	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	7862761	37951728	121186935	147	3462										
NPC1L1	29881	broad.mit.edu	37	chr7	44571714	44571714	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gatccagtgcagcaggaaggGggcataagccttttggaaga	15	7	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:44571714G>C	ENST00000289547.4	-	9	2567	c.2512C>G	c.(2512-2514)Ccc>Gcc	p.P838A	NPC1L1_ENST00000546276.1_Missense_Mutation_p.P838A|NPC1L1_ENST00000381160.3_Missense_Mutation_p.P838A	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	838					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AGCAGGAAGGGGGCATAAGCC	0.642													25	71					0	0	1	0	0	C	44571714	G	C	44571714	3	2	37	1	0	0	0	0	1	0	0	0	10617	1232	43	5	1615	5	NPC1L1	7	44571714	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6619986	44571714	114566949	148	3463										
EIF4H	7458	broad.mit.edu	37	chr7	73588769	73588769	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagcagcttcggcggcggcaGagggtgaggcgggcgtgcgc	21	11	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:73588769G>A	ENST00000265753.8	+	1	195	c.56G>A	c.(55-57)aGa>aAa	p.R19K	EIF4H_ENST00000353999.6_Missense_Mutation_p.R19K	NM_022170.1	NP_071496.1	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	19					interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			endometrium(1)|lung(2)|prostate(1)	4						GGCGGCGGCAGAGGGTGAGGC	0.746													5	22					0	0	1	0	0	A	73588769	G	A	73588769	3	1	37	1	0	0	0	0	1	0	0	0	5067	942	33	3	58	3	EIF4H	7	73588769	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	29017055	73588769	85549894	149	3464										
SLC25A40	55972	broad.mit.edu	37	chr7	87465580	87465580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcactagtattgctgccttCgaacattttgtttctggaaa	7	8	2	0	rs146277655		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:87465580C>T	ENST00000341119.5	-	12	1347	c.1001G>A	c.(1000-1002)cGa>cAa	p.R334Q		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	334					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					TTGCTGCCTTCGAACATTTTG	0.368													3	30					0	0	1	0	0	T	87465580	C	T	87465580	3	4	37	1	0	0	0	0	1	0	0	0	14559	884	31	1	19	1	SLC25A40	7	87465580	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	13876811	87465580	71673083	150	3465										
SAMD9L	219285	broad.mit.edu	37	chr7	92765171	92765171	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aatcctgttacttcttcactGagcagaatttgcccgtattg	7	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:92765171G>A	ENST00000318238.4	-	5	1330	c.114C>T	c.(112-114)ctC>ctT	p.L38L	SAMD9L_ENST00000437805.1_Silent_p.L38L|SAMD9L_ENST00000411955.1_Silent_p.L38L	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	38	SAM.									central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTCTTCACTGAGCAGAATTT	0.398													4	85					0	0	1	0	0	A	92765171	G	A	92765171	2	1	37	1	0	0	0	0	0	0	0	1	13878	1277	45	3		3	SAMD9L	7	92765171	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	5299591	92765171	66373492	151	3466										
ZSCAN21	7589	broad.mit.edu	37	chr7	99661659	99661659	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agagacgttatatatgtgctGaatgtggcaaagcctttagt	11	5	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:99661659G>A	ENST00000292450.4	+	4	1005	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	ZSCAN21_ENST00000456748.2_Intron|ZSCAN21_ENST00000543588.1_Intron|ZSCAN21_ENST00000477297.1_Intron|ZNF3_ENST00000413658.2_3'UTR	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	281					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TATATGTGCTGAATGTGGCAA	0.453													6	70					0	0	1	0	0	A	99661659	G	A	99661659	3	1	37	1	0	0	0	0	1	0	0	0	18273	1291	45	3	851	3	ZSCAN21	7	99661659	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6896488	99661659	59477004	152	3467										
CNPY4	245812	broad.mit.edu	37	chr7	99722164	99722164	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccatgttggaggagtttgaaGacattgtgggagactggtac	15	5	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:99722164G>C	ENST00000262932.3	+	5	625	c.493G>C	c.(493-495)Gac>Cac	p.D165H	CNPY4_ENST00000480692.1_3'UTR|RP11-506M12.1_ENST00000494221.1_RNA	NM_152755.1	NP_689968.1	Q8N129	CNPY4_HUMAN	canopy FGF signaling regulator 4	165	Glu-rich.					extracellular region				breast(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGAGTTTGAAGACATTGTGGG	0.512													12	79					0	0	1	0	0	C	99722164	G	C	99722164	3	2	37	1	0	0	0	0	1	0	0	0	3653	942	33	2	511	2	CNPY4	7	99722164	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	60505	99722164	59416499	153	3468										
CNPY4	245812	broad.mit.edu	37	chr7	99722494	99722494	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caggaagccaccccaaacttGaccgagaagatctttgaccc	8	14	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:99722494G>A	ENST00000262932.3	+	6	862	c.730G>A	c.(730-732)Gac>Aac	p.D244N	CNPY4_ENST00000480692.1_3'UTR|RP11-506M12.1_ENST00000494221.1_RNA	NM_152755.1	NP_689968.1	Q8N129	CNPY4_HUMAN	canopy FGF signaling regulator 4	244						extracellular region				breast(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCCAAACTTGACCGAGAAGA	0.557													11	158					0	0	1	0	0	A	99722494	G	A	99722494	3	1	37	1	0	0	0	0	1	0	0	0	3653	1290	45	3	752	3	CNPY4	7	99722494	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	330	99722494	59416169	154	3469										
ZAN	7455	broad.mit.edu	37	chr7	100365264	100365265	+	RNA	INS	-	-	T													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgcaccacctgcacggctaaINSttttttttttcactttttgt							TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:100365264_100365265insT	ENST00000542585.1	+	0	5008				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			tgcacggctaattttttttttc	0.535													2	4	---	---	---	---						T	100365265	-	T	100365264	6	5	37	0	1	1	1	0	0	0	0	0	17572	116	4	0		0	ZAN	7	100365264	RNA	INS	-	TCGA-N9-A4Q7-01A-11D-A28R-08	642770	100365264	58773399	155	3470										
MUC17	140453	broad.mit.edu	37	chr7	100683260	100683260	+	Missense_Mutation	SNP	G	G	A													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gttcatctcctacaactgctGaaggtatcgtcgtgccaatc							TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:100683260G>A	ENST00000306151.4	+	3	8627	c.8563G>A	c.(8563-8565)Gaa>Aaa	p.E2855K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2855	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACAACTGCTGAAGGTATCGT	0.507													8	586					0	0	1	0	0	A	100683260	G	A	100683260	3	1	37	1	0	0	0	0	1	0	0	0	10021	1291	45	3	8573	3	MUC17	7	100683260	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	317996	100683260	58455403	156	3471	15	2								
MUC17	140453	broad.mit.edu	37	chr7	100683261	100683261	+	Missense_Mutation	SNP	A	A	T													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcatctcctacaactgctgAaggtatcgtcgtgccaatct							TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:100683261A>T	ENST00000306151.4	+	3	8628	c.8564A>T	c.(8563-8565)gAa>gTa	p.E2855V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2855	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAACTGCTGAAGGTATCGTC	0.512													6	595					0	0	1	0	0	T	100683261	A	T	100683261	3	4	37	1	0	0	0	0	1	0	0	0	10021	246	9	4	8574	4	MUC17	7	100683261	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	1	100683261	58455402	157	3472	15	2								
POLR2J3	548644	broad.mit.edu	37	chr7	102212948	102212948	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcgaagagcaagaacgactcGaaggctggaggggcgttcat	15	8	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:102212948G>C	ENST00000511313.1	-	1	82	c.21C>G	c.(19-21)ttC>ttG	p.F7L	RP11-514P8.7_ENST00000514917.2_Intron|POLR2J3_ENST00000504157.1_5'UTR|POLR2J3_ENST00000513438.1_Missense_Mutation_p.F7L			Q9GZM3	RPB1B_HUMAN	polymerase (RNA) II (DNA directed) polypeptide J3	7						nucleus	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity										AGAACGACTCGAAGGCTGGAG	0.667													8	233					0	0	1	0	0	C	102212948	G	C	102212948	3	2	37	1	0	0	0	0	1	0	0	0	12272	1049	37	2	342	2	POLR2J3	7	102212948	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1529687	102212948	56925715	158	3473										
PTPRZ1	5803	broad.mit.edu	37	chr7	121652283	121652283	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caaattccttctttcaatgaGatggtttacccttctgaaag	6	9	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:121652283G>C	ENST00000393386.2	+	12	3594	c.3183G>C	c.(3181-3183)gaG>gaC	p.E1061D	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1061					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.E1061E(3)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CTTTCAATGAGATGGTTTACC	0.348													10	83					0	0	1	0	0	C	121652283	G	C	121652283	3	2	37	1	0	0	0	0	1	0	0	0	12865	933	33	2	3229	2	PTPRZ1	7	121652283	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	19439335	121652283	37486380	159	3474										
TNPO3	23534	broad.mit.edu	37	chr7	128610355	128610356	+	Frame_Shift_Del	DEL	AA	AA	-													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcagttctttccgtaattcAaagtcttcttcatgctgtat							TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:128610355_128610356delAA	ENST00000393245.1	-	20	2919_2920	c.2546_2547delTT	c.(2545-2547)tfs	p.F849fs	TNPO3_ENST00000482320.1_Frame_Shift_Del_p.F749fs|TNPO3_ENST00000471234.1_Frame_Shift_Del_p.F751fs|TNPO3_ENST00000471166.1_Frame_Shift_Del_p.F849fs|TNPO3_ENST00000265388.5_Frame_Shift_Del_p.F815fs	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	815					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						TCCGTAATTCAAAGTCTTCTTC	0.455													49	177	---	---	---	---						-	128610356	AA	-	128610355	7	5	37	1	0	1	0	1	0	0	0	0	16396	127	5	0	338	0	TNPO3	7	128610355	Frame_Shift_Del	DEL	AA	TCGA-N9-A4Q7-01A-11D-A28R-08	6958072	128610355	30528308	160	3475										
TSGA13	114960	broad.mit.edu	37	chr7	130356587	130356587	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcctcaaagcgtagacttttGaatacttcccttcgctcttg	6	12	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:130356587G>C	ENST00000456951.1	-	8	1423	c.572C>G	c.(571-573)tCa>tGa	p.S191*	TSGA13_ENST00000356588.3_Nonsense_Mutation_p.S191*			Q96PP4	TSG13_HUMAN	testis specific, 13	191										endometrium(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	18	Melanoma(18;0.0435)					GTAGACTTTTGAATACTTCCC	0.423													14	57					0	0	1	0	0	C	130356587	G	C	130356587	4	2	37	1	0	0	0	0	0	1	0	0	16679	1294	45	2	263	2	TSGA13	7	130356587	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1746232	130356587	28782076	161	3476										
CLCN1	1180	broad.mit.edu	37	chr7	143028681	143028681	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgggagctgtatttgtgtatCtgcatcgccaagtcatgctc	11	9	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr7:143028681C>G	ENST00000343257.2	+	10	1189	c.1102C>G	c.(1102-1104)Ctg>Gtg	p.L368V		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	368					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity	p.L368V(1)		breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					ATTTGTGTATCTGCATCGCCA	0.473													7	62					0	0	1	0	0	G	143028681	C	G	143028681	3	3	37	1	0	0	0	0	1	0	0	0	3485	912	32	2	1140	2	CLCN1	7	143028681	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	12672094	143028681	16109982	162	3477										
EBF2	64641	broad.mit.edu	37	chr8	25715961	25715961	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggtactgtaattagactgttGaggcgtggagctggaagagt	16	4	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:25715961G>A	ENST00000520164.1	-	14	1939	c.1402C>T	c.(1402-1404)Caa>Taa	p.Q468*	EBF2_ENST00000408929.3_Nonsense_Mutation_p.Q320*|EBF2_ENST00000535548.1_Nonsense_Mutation_p.Q199*	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	468	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTAGACTGTTGAGGCGTGGAG	0.502													7	69					0	0	1	0	0	A	25715961	G	A	25715961	4	1	37	1	0	0	0	0	0	1	0	0	4907	1299	45	3	337	3	EBF2	8	25715961	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		25715961	120648061	163	3478										
WRN	7486	broad.mit.edu	37	chr8	30989971	30989971	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cttttgtctgctgtggacatCttaggcgaaaaatttggaat	10	6	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:30989971C>G	ENST00000298139.5	+	24	3165	c.2916C>G	c.(2914-2916)atC>atG	p.I972M		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	972					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTGTGGACATCTTAGGCGAAA	0.368			"Mis, N, F, S"			"osteosarcoma, meningioma, others"		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				6	21					0	0	1	0	0	G	30989971	C	G	30989971	3	3	37	1	0	0	0	0	1	0	0	0	17461	903	32	2	3006	2	WRN	8	30989971	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5274010	30989971	115374051	164	3479										
PREX2	80243	broad.mit.edu	37	chr8	69103983	69103983	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctacttggacaagtcaaattCaccaccaaactccacatcca	3	15	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:69103983C>T	ENST00000288368.4	+	36	4650	c.4373C>T	c.(4372-4374)tCa>tTa	p.S1458L		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1458					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAGTCAAATTCACCACCAAAC	0.303													7	23					0	0	1	0	0	T	69103983	C	T	69103983	3	4	37	1	0	0	0	0	1	0	0	0	12528	838	29	3	4744	3	PREX2	8	69103983	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	38114012	69103983	77260039	165	3480										
FAM92A1	137392	broad.mit.edu	37	chr8	94740446	94740446	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttaacaggtatccacttgtcGactaagaaaggatcaacaag	8	8	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:94740446G>A	ENST00000518322.1	+	9	932	c.791G>A	c.(790-792)cGa>cAa	p.R264Q	FAM92A1_ENST00000520363.1_3'UTR|FAM92A1_ENST00000517718.1_Missense_Mutation_p.R109Q|FAM92A1_ENST00000423990.2_Missense_Mutation_p.R226Q	NM_145269.3	NP_660312.2	A1XBS5	F92A1_HUMAN	family with sequence similarity 92, member A1	264										NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)	7	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TCCACTTGTCGACTAAGAAAG	0.279													6	37					0	0	1	0	0	A	94740446	G	A	94740446	3	1	37	1	0	0	0	0	1	0	0	0	5684	1058	37	1	821	1	FAM92A1	8	94740446	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	25636463	94740446	51623576	166	3481										
ESRP1	54845	broad.mit.edu	37	chr8	95676969	95676969	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	taacaccgtagtcagggcacGaggtttaccatggcagtctt	11	10	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:95676969G>A	ENST00000433389.2	+	7	879	c.689G>A	c.(688-690)cGa>cAa	p.R230Q	ESRP1_ENST00000358397.5_Missense_Mutation_p.R230Q|ESRP1_ENST00000454170.2_Missense_Mutation_p.R230Q|ESRP1_ENST00000423620.2_Missense_Mutation_p.R230Q	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	230	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						GTCAGGGCACGAGGTTTACCA	0.383													8	50					0	0	1	0	0	A	95676969	G	A	95676969	3	1	37	1	0	0	0	0	1	0	0	0	5286	1058	37	1	715	1	ESRP1	8	95676969	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	936523	95676969	50687053	167	3482										
VPS13B	157680	broad.mit.edu	37	chr8	100205244	100205244	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggaaatgtcagctcttccgCagtgattgaagctttgataa	10	7	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:100205244C>T	ENST00000395996.1	+	17	2585	c.2474C>T	c.(2473-2475)gCa>gTa	p.A825V	VPS13B_ENST00000521932.1_3'UTR|VPS13B_ENST00000358544.2_Missense_Mutation_p.A825V|VPS13B_ENST00000357162.2_Missense_Mutation_p.A825V|VPS13B_ENST00000355155.1_Missense_Mutation_p.A825V			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	825					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGCTCTTCCGCAGTGATTGAA	0.358													4	38					0	0	1	0	0	T	100205244	C	T	100205244	3	4	37	1	0	0	0	0	1	0	0	0	17249	710	25	3	2578	3	VPS13B	8	100205244	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4528275	100205244	46158778	168	3483										
FER1L6	654463	broad.mit.edu	37	chr8	125076587	125076587	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctgatgtgctttcatttcaGatatttcagattcgctaaca	6	9	3	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:125076587G>T	ENST00000522917.1	+	26	3534		c.e26-1		FER1L6_ENST00000399018.1_Splice_Site|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)							integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TTTCATTTCAGATATTTCAGA	0.507													17	107					4.14922e-12	4.53495e-12	1	1	0	T	125076587	G	T	125076587	5	4	37	1	0	0	0	0	0	0	1	0	5847	956	33	2	3426	2	FER1L6	8	125076587	Splice_Site	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	24871343	125076587	21287435	169	3484										
ASAP1	50807	broad.mit.edu	37	chr8	131172206	131172206	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcctccttgccggctctgaGaatcctaggaaagaaaaact	8	11	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr8:131172206G>C	ENST00000357668.1	-	11	941	c.914C>G	c.(913-915)tCt>tGt	p.S305C	ASAP1_ENST00000518721.1_Missense_Mutation_p.S305C			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	305					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						CCGGCTCTGAGAATCCTAGGA	0.443													9	63					0	0	1	0	0	C	131172206	G	C	131172206	3	2	37	1	0	0	0	0	1	0	0	0	1009	942	33	2	2551	2	ASAP1	8	131172206	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6095619	131172206	15191816	170	3485										
ELAVL2	1993	broad.mit.edu	37	chr9	23692637	23692637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atccattgaggctagctatcGccatggcagcctcatcatag	9	12	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:23692637G>A	ENST00000397312.2	-	7	1272	c.998C>T	c.(997-999)gCg>gTg	p.A333V	ELAVL2_ENST00000223951.6_Missense_Mutation_p.A320V|ELAVL2_ENST00000380110.4_Missense_Mutation_p.A363V|ELAVL2_ENST00000380117.1_Missense_Mutation_p.A333V|ELAVL2_ENST00000544538.1_Missense_Mutation_p.A333V	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	333	RRM 3.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		GCTAGCTATCGCCATGGCAGC	0.453													19	44					0	0	1	0	0	A	23692637	G	A	23692637	3	1	37	1	0	0	0	0	1	0	0	0	5078	1087	38	1	85	1	ELAVL2	9	23692637	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		23692637	117520794	171	3486										
KIAA1161	57462	broad.mit.edu	37	chr9	34372195	34372195	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agcgagcgctccgtgctgttCcagcccaggtggaagggcac	15	13	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:34372195C>G	ENST00000297625.7	-	2	870	c.645G>C	c.(643-645)tgG>tgC	p.W215C		NM_020702.3	NP_065753.2	Q6NSJ0	K1161_HUMAN	KIAA1161	249					carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CCGTGCTGTTCCAGCCCAGGT	0.687													6	17					0	0	1	0	0	G	34372195	C	G	34372195	3	3	37	1	0	0	0	0	1	0	0	0	8252	856	30	2	1401	2	KIAA1161	9	34372195	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10679558	34372195	106841236	172	3487										
RUSC2	9853	broad.mit.edu	37	chr9	35560367	35560367	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtggagaagaggaagaggaaGaagaggagacagaagaggtg	20	1	0	8			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:35560367G>C	ENST00000455600.1	+	10	4299	c.3730G>C	c.(3730-3732)Gaa>Caa	p.E1244Q		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1244	Poly-Glu.					cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ggaagaggaagaagaggagac	0.687													9	30					0	0	1	0	0	C	35560367	G	C	35560367	3	2	37	1	0	0	0	0	1	0	0	0	13802	943	33	2	3764	2	RUSC2	9	35560367	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1188172	35560367	105653064	173	3488										
RUSC2	9853	broad.mit.edu	37	chr9	35561242	35561242	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agctgagcttccacaaaggaGacatcctacgagtgctgggg	13	10	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:35561242G>A	ENST00000455600.1	+	12	4983	c.4414G>A	c.(4414-4416)Gac>Aac	p.D1472N		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1472	SH3.					cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CCACAAAGGAGACATCCTACG	0.652													8	80					0	0	1	0	0	A	35561242	G	A	35561242	3	1	37	1	0	0	0	0	1	0	0	0	13802	942	33	3	4456	3	RUSC2	9	35561242	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	875	35561242	105652189	174	3489										
PTPN3	0	broad.mit.edu	37	chr9	112195361	112195361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtttgcacttaccaaggataGaaacttgtgcaaatgtattt	8	6	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:112195361G>C	ENST00000412145.1	-	5	2916	c.363C>G	c.(361-363)ttC>ttG	p.F121L	PTPN3_ENST00000374541.2_Missense_Mutation_p.F252L|PTPN3_ENST00000446349.1_Missense_Mutation_p.F121L|PTPN3_ENST00000262539.3_Missense_Mutation_p.F143L	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	252	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						ACCAAGGATAGAAACTTGTGC	0.348													5	36					0	0	1	0	0	C	112195361	G	C	112195361	3	2	37	1	0	0	0	0	1	0	0	0	12840	933	33	2	2053	2	PTPN3	9	112195361	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	76634119	112195361	29018070	175	3490										
PDCL	5082	broad.mit.edu	37	chr9	125588934	125588934	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcgcctgccagctcagcctCtgcaggcacagaactgctgg	11	15	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:125588934C>G	ENST00000259467.4	-	2	298	c.133G>C	c.(133-135)Gag>Cag	p.E45Q		NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like	45					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						AGCTCAGCCTCTGCAGGCACA	0.502													6	45					0	0	1	0	0	G	125588934	C	G	125588934	3	3	37	1	0	0	0	0	1	0	0	0	11672	922	32	2	784	2	PDCL	9	125588934	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	13393573	125588934	15624497	176	3491										
ABCA2	20	broad.mit.edu	37	chr9	139910184	139910184	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcgcgcgtaggggtccacgcCcgccgtgggctcgtccagga	17	15	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:139910184C>G	ENST00000265662.5	-	23	3604	c.3457G>C	c.(3457-3459)Ggc>Cgc	p.G1153R	ABCA2_ENST00000341511.6_Missense_Mutation_p.G1153R|ABCA2_ENST00000371605.3_Missense_Mutation_p.G1152R			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1152	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGGTCCACGCCCGCCGTGGGC	0.692													5	33					0	0	1	0	0	G	139910184	C	G	139910184	3	3	37	1	0	0	0	0	1	0	0	0	32	623	22	5	3961	5	ABCA2	9	139910184	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	14321250	139910184	1303247	177	3492										
MAN1B1	11253	broad.mit.edu	37	chr9	139995996	139995996	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	catccaagattccttactcgGatgtgaacatcggtactgga	9	10	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr9:139995996G>A	ENST00000371589.4	+	8	1199	c.1126G>A	c.(1126-1128)Gat>Aat	p.D376N	MAN1B1_ENST00000474902.1_Missense_Mutation_p.D79N	NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	376					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		TCCTTACTCGGATGTGAACAT	0.547													5	42					0	0	1	0	0	A	139995996	G	A	139995996	3	1	37	1	0	0	0	0	1	0	0	0	9261	1174	41	3	1156	3	MAN1B1	9	139995996	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	85812	139995996	1217435	178	3493										
OLAH	55301	broad.mit.edu	37	chr10	15115119	15115119	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aaccagtggaaatgctaaaaTttaccagcttccagggggtc	10	9	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:15115119T>C	ENST00000378217.3	+	9	1035	c.848T>C	c.(847-849)aTt>aCt	p.I283T	OLAH_ENST00000378228.3_Missense_Mutation_p.I230T|OLAH_ENST00000485251.1_3'UTR	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	230					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						AATGCTAAAATTTACCAGCTT	0.368													4	35					0	0	1	0	0	C	15115119	T	C	15115119	3	2	37	1	0	0	0	0	1	0	0	0	10898	1493	52	4	878	4	OLAH	10	15115119	Missense_Mutation	SNP	T	TCGA-N9-A4Q7-01A-11D-A28R-08		15115119	120419628	179	3494										
KIAA1462	57608	broad.mit.edu	37	chr10	30317227	30317227	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gactctgttcttgcagagccGggctcttatcagacccattc	9	13	4	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:30317227G>T	ENST00000375377.1	-	3	1951	c.1850C>A	c.(1849-1851)cCg>cAg	p.P617Q		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	617										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TTGCAGAGCCGGGCTCTTATC	0.493													26	38					3.01185e-09	3.26722e-09	1	1	0	T	30317227	G	T	30317227	3	4	37	1	0	0	0	0	1	0	0	0	8275	1116	39	5	2237	5	KIAA1462	10	30317227	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	15202108	30317227	105217520	180	3495										
FAM21A	387680	broad.mit.edu	37	chr10	51892695	51892695	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgatcccctgaatgcctttgGaggccagtagagcacacagg	12	11	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:51892695G>A	ENST00000351071.6	+	30	4071	c.3953G>A	c.(3952-3954)gGa>gAa	p.G1318E	FAM21A_ENST00000399339.2_Missense_Mutation_p.G1251E|FAM21A_ENST00000282633.5_Missense_Mutation_p.G1339E|FAM21A_ENST00000314664.7_Missense_Mutation_p.G1277E			Q641Q2	FA21A_HUMAN	family with sequence similarity 21, member A	1339					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	15						AATGCCTTTGGAGGCCAGTAG	0.453													12	47					0	0	1	0	0	A	51892695	G	A	51892695	3	1	37	1	0	0	0	0	1	0	0	0	5571	1174	41	3	4138	3	FAM21A	10	51892695	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	21575468	51892695	83642052	181	3496										
AP3M1	26985	broad.mit.edu	37	chr10	75883653	75883653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tctccccatacatgtccaaaCggtttacttttaagcctgta	5	12	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:75883653C>T	ENST00000355264.4	-	9	1483	c.1172G>A	c.(1171-1173)cGt>cAt	p.R391H	AP3M1_ENST00000372745.1_Missense_Mutation_p.R391H	NM_012095.4	NP_036227.1	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	391	MHD.				protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	13	Prostate(51;0.0112)					CATGTCCAAACGGTTTACTTT	0.353													18	68					0	0	1	0	0	T	75883653	C	T	75883653	3	4	37	1	0	0	0	0	1	0	0	0	743	536	19	1	88	1	AP3M1	10	75883653	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	23990958	75883653	59651094	182	3497										
STAMBPL1	57559	broad.mit.edu	37	chr10	90665330	90665330	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tccacgacgttactttaggtCtggagtagagatggagagga	14	6	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:90665330C>G	ENST00000371927.3	+	3	1119	c.161C>G	c.(160-162)tCt>tGt	p.S54C	STAMBPL1_ENST00000371924.1_Missense_Mutation_p.S54C|STAMBPL1_ENST00000371926.3_Missense_Mutation_p.S54C			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	54							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TACTTTAGGTCTGGAGTAGAG	0.408													14	53					0	0	1	0	0	G	90665330	C	G	90665330	3	3	37	1	0	0	0	0	1	0	0	0	15306	913	32	2	167	2	STAMBPL1	10	90665330	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	14781677	90665330	44869417	183	3498										
IDE	3416	broad.mit.edu	37	chr10	94294450	94294450	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	actgagaaactggctgtattCattttctttagggtatttct	8	6	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:94294450C>T	ENST00000265986.6	-	3	432	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	126					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGCTGTATTCATTTTCTTTA	0.368													5	38					0	0	1	0	0	T	94294450	C	T	94294450	3	4	37	1	0	0	0	0	1	0	0	0	7536	835	29	3	2775	3	IDE	10	94294450	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3629120	94294450	41240297	184	3499										
HPS6	79803	broad.mit.edu	37	chr10	103825882	103825882	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggcgtggcccacgttctactCatctggagcccaggcaaggg	14	13	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:103825882C>G	ENST00000299238.5	+	1	736	c.651C>G	c.(649-651)ctC>ctG	p.L217L		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	217						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		ACGTTCTACTCATCTGGAGCC	0.622									Hermansky-Pudlak syndrome				23	58					0	0	1	0	0	G	103825882	C	G	103825882	2	3	37	1	0	0	0	0	0	0	0	1	7383	813	29	2		2	HPS6	10	103825882	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	9531432	103825882	31708865	185	3500										
NOLC1	9221	broad.mit.edu	37	chr10	103921999	103921999	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggctcaatctctgtccaggtCaattctattaagtttgacag	8	9	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:103921999C>T	ENST00000405356.1	+	13	2338	c.2103C>T	c.(2101-2103)gtC>gtT	p.V701V	NOLC1_ENST00000488254.2_Silent_p.V692V|NOLC1_ENST00000605788.1_Silent_p.V691V|NOLC1_ENST00000477977.1_Intron|NOLC1_ENST00000603742.1_Silent_p.V410V			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	691					mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		CTGTCCAGGTCAATTCTATTA	0.507													32	208					0	0	1	0	0	T	103921999	C	T	103921999	2	4	37	1	0	0	0	0	0	0	0	1	10575	813	29	3		3	NOLC1	10	103921999	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	96117	103921999	31612748	186	3501										
SORCS1	114815	broad.mit.edu	37	chr10	108412181	108412181	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agtgacgttgtgtccttgttCcgctgtcagctttccatcag	10	11	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:108412181C>A	ENST00000263054.6	-	18	2441	c.2434G>T	c.(2434-2436)Gaa>Taa	p.E812*	SORCS1_ENST00000369698.1_Nonsense_Mutation_p.E347*|SORCS1_ENST00000344440.6_Nonsense_Mutation_p.E812*	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	812	PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGTCCTTGTTCCGCTGTCAGC	0.522													10	58					4.68919e-08	5.02413e-08	1	1	0	A	108412181	C	A	108412181	4	1	37	1	0	0	0	0	0	1	0	0	14983	864	30	2	1342	2	SORCS1	10	108412181	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4490182	108412181	27122566	187	3502										
DCLRE1A	9937	broad.mit.edu	37	chr10	115608914	115608914	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ataaggtgatctgatctcttCtgacacgctccttcctgcag	8	12	3	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:115608914C>G	ENST00000361384.2	-	2	2867	c.1950G>C	c.(1948-1950)caG>caC	p.Q650H	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.Q650H	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	650					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		CTGATCTCTTCTGACACGCTC	0.413								Other identified genes with known or suspected DNA repair function					20	124					0	0	1	0	0	G	115608914	C	G	115608914	3	3	37	1	0	0	0	0	1	0	0	0	4317	912	32	2	1204	2	DCLRE1A	10	115608914	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	7196733	115608914	19925833	188	3503										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118354353	118354353	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gagtggtgggcgcccaggtgGcccagatgctcgacatcctc	15	13	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:118354353G>A	ENST00000528052.1	+	5	513	c.442G>A	c.(442-444)Gcc>Acc	p.A148T	PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.A148T|PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.A148T			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	148					lipid metabolic process		calcium ion binding|triglyceride lipase activity	p.A148S(2)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CGCCCAGGTGGCCCAGATGCT	0.602													8	26					0	0	1	0	0	A	118354353	G	A	118354353	3	1	37	1	0	0	0	0	1	0	0	0	12197	1203	42	3	456	3	PNLIPRP1	10	118354353	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2745439	118354353	17180394	189	3504										
PDZD8	118987	broad.mit.edu	37	chr10	119043585	119043585	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgctccacaaacagaagtctCagctagacacttttcttgac	6	12	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:119043585C>G	ENST00000334464.5	-	5	2898	c.2659G>C	c.(2659-2661)Gag>Cag	p.E887Q		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	887					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		ACAGAAGTCTCAGCTAGACAC	0.433													8	53					0	0	1	0	0	G	119043585	C	G	119043585	3	3	37	1	0	0	0	0	1	0	0	0	11751	835	29	2	809	2	PDZD8	10	119043585	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	689232	119043585	16491162	190	3505										
MKI67	4288	broad.mit.edu	37	chr10	129900912	129900912	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcatgtcgttgctgttcagCtcttccgcaggttcaattct	8	11	5	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:129900912C>G	ENST00000368654.3	-	13	9567	c.9192G>C	c.(9190-9192)gaG>gaC	p.E3064D	MKI67_ENST00000368653.3_Missense_Mutation_p.E2704D	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	3064					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGCTGTTCAGCTCTTCCGCAG	0.448													10	92					0	0	1	0	0	G	129900912	C	G	129900912	3	3	37	1	0	0	0	0	1	0	0	0	9645	796	28	5	590	5	MKI67	10	129900912	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10857327	129900912	5633835	191	3506										
INPP5A	3632	broad.mit.edu	37	chr10	134563349	134563349	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgagacaacaacggcaccgcGgtgagtttgtggtccaatgt	13	10	0	2	rs142848612		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr10:134563349G>A	ENST00000368594.3	+	11	1180	c.903_splice	c.e11+1	p.A301_splice	INPP5A_ENST00000368593.3_Splice_Site_p.A301_splice	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	301					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		ACGGCACCGCGGTGAGTTTGT	0.562													17	81					0	0	1	0	0	A	134563349	G	A	134563349	5	1	37	1	0	0	0	0	0	0	1	0	7797	1130	39	1	945	1	INPP5A	10	134563349	Splice_Site	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4662437	134563349	971398	192	3507										
DCHS1	8642	broad.mit.edu	37	chr11	6655238	6655238	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acaccttcacatataccatgGacttgaggcctccctggtgg	9	13	1	1	rs146086570	byFrequency	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:6655238G>C	ENST00000299441.3	-	4	2411	c.2000C>G	c.(1999-2001)tCc>tGc	p.S667C	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	667	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATATACCATGGACTTGAGGCC	0.552													9	60					0	0	1	0	0	C	6655238	G	C	6655238	3	2	37	1	0	0	0	0	1	0	0	0	4310	1174	41	2	7968	2	DCHS1	11	6655238	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		6655238	128351278	193	3508										
MICAL2	9645	broad.mit.edu	37	chr11	12280035	12280035	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcaaattttactgcaagcctCacttcattcactgtaaaacc	4	12	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:12280035C>T	ENST00000256194.4	+	25	3451	c.3163C>T	c.(3163-3165)Cac>Tac	p.H1055Y	MICAL2_ENST00000537344.1_Missense_Mutation_p.H865Y|MICAL2_ENST00000342902.5_Missense_Mutation_p.H1034Y|MICAL2_ENST00000527546.1_Missense_Mutation_p.H865Y|MICAL2_ENST00000379612.3_Missense_Mutation_p.H829Y	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	1055	LIM zinc-binding.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CTGCAAGCCTCACTTCATTCA	0.418													4	84					0	0	1	0	0	T	12280035	C	T	12280035	3	4	37	1	0	0	0	0	1	0	0	0	9617	826	29	3	3253	3	MICAL2	11	12280035	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5624797	12280035	122726481	194	3509										
COPB1	1315	broad.mit.edu	37	chr11	14490983	14490983	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	attcattaaaggtgaacattCagacaagaccttgaggcaca	8	8	2	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:14490983C>G	ENST00000249923.3	-	15	2164	c.1864G>C	c.(1864-1866)Gaa>Caa	p.E622Q	COPB1_ENST00000439561.2_Missense_Mutation_p.E622Q	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	622					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						GGTGAACATTCAGACAAGACC	0.388													4	59					0	0	1	0	0	G	14490983	C	G	14490983	3	3	37	1	0	0	0	0	1	0	0	0	3751	835	29	2	1029	2	COPB1	11	14490983	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2210948	14490983	120515533	195	3510										
PRR5L	79899	broad.mit.edu	37	chr11	36484194	36484194	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccaccggcagtgctccagtGagcccaacatcactgacaac	8	17	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:36484194G>C	ENST00000378867.3	+	10	1370	c.1015G>C	c.(1015-1017)Gag>Cag	p.E339Q	PRR5L_ENST00000311599.5_Missense_Mutation_p.E266Q|PRR5L_ENST00000389693.3_3'UTR|PRR5L_ENST00000530639.1_Missense_Mutation_p.E339Q	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	339										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						GTGCTCCAGTGAGCCCAACAT	0.667													11	38					0	0	1	0	0	C	36484194	G	C	36484194	3	2	37	1	0	0	0	0	1	0	0	0	12651	1291	45	2	1051	2	PRR5L	11	36484194	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	21993211	36484194	98522322	196	3511										
OR4C16	219428	broad.mit.edu	37	chr11	55339928	55339928	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccatgtctttggctgcctgGagatcttcatcctcatcctc	7	15	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:55339928G>C	ENST00000314634.3	+	1	325	c.325G>C	c.(325-327)Gag>Cag	p.E109Q		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TGGCTGCCTGGAGATCTTCAT	0.483													17	126					0	0	1	0	0	C	55339928	G	C	55339928	3	2	37	1	0	0	0	0	1	0	0	0	11096	1175	41	2	327	2	OR4C16	11	55339928	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	18855734	55339928	79666588	197	3512										
YPEL4	219539	broad.mit.edu	37	chr11	57413814	57413814	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcagctctcacagaaaatgtCagctaccgagtggagccccg	11	13	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:57413814C>T	ENST00000524669.1	-	4	2972	c.250G>A	c.(250-252)Gac>Aac	p.D84N	YPEL4_ENST00000544993.1_Missense_Mutation_p.D84N|YPEL4_ENST00000534711.1_Missense_Mutation_p.D84N|YPEL4_ENST00000300022.3_Missense_Mutation_p.D84N|AP000662.4_ENST00000530595.1_RNA			Q96NS1	YPEL4_HUMAN	yippee-like 4 (Drosophila)	84						nucleolus				lung(2)|skin(1)	3						CAGAAAATGTCAGCTACCGAG	0.567													6	75					0	0	1	0	0	T	57413814	C	T	57413814	3	4	37	1	0	0	0	0	1	0	0	0	17551	826	29	3	141	3	YPEL4	11	57413814	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2073886	57413814	77592702	198	3513										
UBXN1	51035	broad.mit.edu	37	chr11	62444465	62444465	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctgggtcagtgaggtcccatCtggcagcctgacctaaaggg	14	11	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:62444465C>T	ENST00000294119.2	-	8	795	c.664G>A	c.(664-666)Gat>Aat	p.D222N	UBXN1_ENST00000533000.1_Intron|UBXN1_ENST00000529640.1_Missense_Mutation_p.D218N|UBXN1_ENST00000524762.1_5'UTR|UBXN1_ENST00000301935.5_Missense_Mutation_p.D222N	NM_015853.3	NP_056937.2	Q04323	UBXN1_HUMAN	UBX domain protein 1	222	Interaction with BRCA1.|UBX.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding			endometrium(5)|lung(12)	17						GAGGTCCCATCTGGCAGCCTG	0.582													10	84					0	0	1	0	0	T	62444465	C	T	62444465	3	4	37	1	0	0	0	0	1	0	0	0	16970	913	32	3	278	3	UBXN1	11	62444465	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5030651	62444465	72562051	199	3514										
TAF6L	10629	broad.mit.edu	37	chr11	62549791	62549791	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gatggggctgccctcctgctCagccacatcttctggtagcc	11	15	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:62549791C>G	ENST00000294168.3	+	8	1014	c.813C>G	c.(811-813)ctC>ctG	p.L271L	TMEM223_ENST00000527073.1_Intron	NM_006473.3	NP_006464.1	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	271					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)	16						CCCTCCTGCTCAGCCACATCT	0.607													37	100					0	0	1	0	0	G	62549791	C	G	62549791	2	3	37	1	0	0	0	0	0	0	0	1	15587	813	29	2		2	TAF6L	11	62549791	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	105326	62549791	72456725	200	3515										
PLCB3	5331	broad.mit.edu	37	chr11	64033632	64033632	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagggaggtcgtccttgatgCaaacacaactcagttcaaga	10	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:64033632C>G	ENST00000540288.1	+	27	3327	c.3224C>G	c.(3223-3225)gCa>gGa	p.A1075G	PLCB3_ENST00000325234.5_Missense_Mutation_p.A1008G|PLCB3_ENST00000279230.6_Missense_Mutation_p.A1075G	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	1075					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						GTCCTTGATGCAAACACAACT	0.567													10	164					0	0	1	0	0	G	64033632	C	G	64033632	3	3	37	1	0	0	0	0	1	0	0	0	12076	710	25	5	3330	5	PLCB3	11	64033632	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1483841	64033632	70972884	201	3516										
CDC42EP2	10435	broad.mit.edu	37	chr11	65088726	65088726	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcggtggaccccaggctctCaccctgcccacagcccaggc	10	19	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:65088726C>T	ENST00000544348.1	+	2	963	c.357C>T	c.(355-357)ctC>ctT	p.L119L	CDC42EP2_ENST00000279249.2_Silent_p.L119L|CDC42EP2_ENST00000533419.1_Silent_p.L119L			O14613	BORG1_HUMAN	CDC42 effector protein (Rho GTPase binding) 2	119					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity			lung(1)	1						CCCAGGCTCTCACCCTGCCCA	0.692													13	77					0	0	1	0	0	T	65088726	C	T	65088726	2	4	37	1	0	0	0	0	0	0	0	1	3098	813	29	3		3	CDC42EP2	11	65088726	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1055094	65088726	69917790	202	3517										
C2CD3	26005	broad.mit.edu	37	chr11	73850728	73850728	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatgtatgtcgcgaggccttGatggaacctgaaactgggta	13	7	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:73850728G>C	ENST00000334126.7	-	4	855	c.629C>G	c.(628-630)tCa>tGa	p.S210*	C2CD3_ENST00000313663.7_Nonsense_Mutation_p.S210*|C2CD3_ENST00000539061.1_Nonsense_Mutation_p.S210*			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	210						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					GCGAGGCCTTGATGGAACCTG	0.438													25	170					0	0	1	0	0	C	73850728	G	C	73850728	4	2	37	1	0	0	0	0	0	1	0	0	2168	1294	45	2	5374	2	C2CD3	11	73850728	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	8762002	73850728	61155788	203	3518										
RSF1	51773	broad.mit.edu	37	chr11	77412843	77412843	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccctccgtgatgatatttctGtccttagaggggctatagct	10	10	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:77412843G>T	ENST00000308488.6	-	6	1733	c.1431C>A	c.(1429-1431)gaC>gaA	p.D477E	RSF1_ENST00000360355.2_Missense_Mutation_p.D446E|RSF1_ENST00000480887.1_Missense_Mutation_p.D225E			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	477					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TGATATTTCTGTCCTTAGAGG	0.398													8	79					0.00307968	0.00314474	1	1	0	T	77412843	G	T	77412843	3	4	37	1	0	0	0	0	1	0	0	0	13750	1368	48	5	2938	5	RSF1	11	77412843	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	3562115	77412843	57593673	204	3519										
TMEM123	114908	broad.mit.edu	37	chr11	102272784	102272784	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggtagaagtcatatttgttGagaccatccctggtgttgtt	11	6	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:102272784G>T	ENST00000398136.2	-	3	731	c.311C>A	c.(310-312)tCa>tAa	p.S104*	TMEM123_ENST00000532161.1_Nonsense_Mutation_p.S16*|TMEM123_ENST00000525577.1_5'UTR|TMEM123_ENST00000361236.3_Nonsense_Mutation_p.S85*	NM_052932.2	NP_443164.2	Q8N131	PORIM_HUMAN	transmembrane protein 123	104	Thr-rich.				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(3)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		CATATTTGTTGAGACCATCCC	0.438													19	180					2.94398e-08	3.16206e-08	1	1	0	T	102272784	G	T	102272784	4	4	37	1	0	0	0	0	0	1	0	0	16095	1294	45	2	327	2	TMEM123	11	102272784	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	24859941	102272784	32733732	205	3520										
ALG9	79796	broad.mit.edu	37	chr11	111747359	111747359	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tacatgaaaggacttatcttGactcctggcaaaatagacac	7	9	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:111747359G>C	ENST00000524880.1	-	4	830	c.538C>G	c.(538-540)Caa>Gaa	p.Q180E	FDXACB1_ENST00000542429.1_Missense_Mutation_p.Q31E|FDXACB1_ENST00000260257.4_Missense_Mutation_p.Q180E|ALG9_ENST00000527377.1_5'UTR			Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	0					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		GACTTATCTTGACTCCTGGCA	0.388													5	47					0	0	1	0	0	C	111747359	G	C	111747359	3	2	37	1	0	0	0	0	1	0	0	0	520	1299	45	2		2	ALG9	11	111747359	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	9474575	111747359	23259157	206	3521										
PCSK7	9159	broad.mit.edu	37	chr11	117090319	117090319	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatctcacccgggtggctgtGaagacaatgatgtgctggac	13	9	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:117090319G>A	ENST00000320934.3	-	10	1941	c.1311C>T	c.(1309-1311)ttC>ttT	p.F437F	PCSK7_ENST00000540028.1_Silent_p.F78F	NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	437	Catalytic.				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GGGTGGCTGTGAAGACAATGA	0.592			T	IGH@	MLCLS								6	56					0	0	1	0	0	A	117090319	G	A	117090319	2	1	37	1	0	0	0	0	0	0	0	1	11651	1281	45	3		3	PCSK7	11	117090319	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	5342960	117090319	17916197	207	3522										
DSCAML1	57453	broad.mit.edu	37	chr11	117303881	117303881	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cttgatgccttctttgtcctCgatgagcagctggaccctgg	11	12	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:117303881C>T	ENST00000321322.6	-	29	5180	c.5179G>A	c.(5179-5181)Gag>Aag	p.E1727K	DSCAML1_ENST00000527706.1_Missense_Mutation_p.E1457K	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1667					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TCTTTGTCCTCGATGAGCAGC	0.562													5	32					0	0	1	0	0	T	117303881	C	T	117303881	3	4	37	1	0	0	0	0	1	0	0	0	4795	893	31	1	1182	1	DSCAML1	11	117303881	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	213562	117303881	17702635	208	3523										
SORL1	6653	broad.mit.edu	37	chr11	121393333	121393333	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cttcatctggctcagcgcctCagtcagctcctcaacctcca	6	18	6	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:121393333C>T	ENST00000260197.7	+	10	1572	c.1443C>T	c.(1441-1443)ctC>ctT	p.L481L	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	481					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTCAGCGCCTCAGTCAGCTCC	0.547													15	195					0	0	1	0	0	T	121393333	C	T	121393333	2	4	37	1	0	0	0	0	0	0	0	1	14987	813	29	3		3	SORL1	11	121393333	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4089452	121393333	13613183	209	3524										
OR10G7	390265	broad.mit.edu	37	chr11	123909026	123909026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgtgcctcccctctgaggtgCggatccgcaggatggaacag	14	12	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:123909026C>T	ENST00000330487.5	-	1	691	c.683G>A	c.(682-684)cGc>cAc	p.R228H		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTCTGAGGTGCGGATCCGCAG	0.537													36	85					0	0	1	0	0	T	123909026	C	T	123909026	3	4	37	1	0	0	0	0	1	0	0	0	10949	768	27	1	256	1	OR10G7	11	123909026	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2515693	123909026	11097490	210	3525										
IGSF9B	22997	broad.mit.edu	37	chr11	133789788	133789788	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggaagggtagccggtggccaGagtggtgaagcccatggcgg	20	8	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:133789788G>T	ENST00000321016.8	-	18	4062	c.3832C>A	c.(3832-3834)Ctg>Atg	p.L1278M	IGSF9B_ENST00000533871.2_Missense_Mutation_p.L1278M			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1278	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCGGTGGCCAGAGTGGTGAAG	0.677													5	30					0.000602214	0.000623722	1	1	0	T	133789788	G	T	133789788	3	4	37	1	0	0	0	0	1	0	0	0	7649	933	33	2	225	2	IGSF9B	11	133789788	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	9880762	133789788	1216728	211	3526										
NCAPD3	23310	broad.mit.edu	37	chr11	134027892	134027892	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cactcctaagctccgactccGatgcctgctctttgactcca	6	17	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr11:134027892G>A	ENST00000534548.2	-	31	4169	c.4105C>T	c.(4105-4107)Cgg>Tgg	p.R1369W		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1369					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CTCCGACTCCGATGCCTGCTC	0.507													20	200					0	0	1	0	0	A	134027892	G	A	134027892	3	1	37	1	0	0	0	0	1	0	0	0	10252	1057	37	1	411	1	NCAPD3	11	134027892	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	238104	134027892	978624	212	3527										
SLC6A12	6539	broad.mit.edu	37	chr12	307135	307135	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acccctggcagatggcaaagGagaagaagatctgggtgccc	14	10	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:307135G>T	ENST00000428720.1	-	9	1624	c.881C>A	c.(880-882)tCc>tAc	p.S294Y	SLC6A12_ENST00000397296.2_Missense_Mutation_p.S294Y|SLC6A12_ENST00000536824.1_Missense_Mutation_p.S294Y|SLC6A12_ENST00000359674.4_Missense_Mutation_p.S294Y|SLC6A12_ENST00000538272.1_5'UTR|SLC6A12_ENST00000424061.2_Missense_Mutation_p.S294Y	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	294					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GATGGCAAAGGAGAAGAAGAT	0.587													5	116					1.024e-07	1.09445e-07	1	1	0	T	307135	G	T	307135	3	4	37	1	0	0	0	0	1	0	0	0	14729	1174	41	2	995	2	SLC6A12	12	307135	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		307135	133544760	213	3528										
RAD52	5893	broad.mit.edu	37	chr12	1036411	1036411	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	actaacaccataaccaacatCttcatgatatgaaccatcct	2	13	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:1036411C>T	ENST00000358495.3	-	6	505	c.367G>A	c.(367-369)Gat>Aat	p.D123N	RAD52_ENST00000539046.1_Missense_Mutation_p.D46N|RAD52_ENST00000536177.1_Missense_Mutation_p.D123N|RAD52_ENST00000545564.1_Missense_Mutation_p.D123N|RAD52_ENST00000430095.2_Missense_Mutation_p.D123N	NM_134424.2	NP_602296.2	P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)	123					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			TAACCAACATCTTCATGATAT	0.537								Homologous recombination					15	238					0	0	1	0	0	T	1036411	C	T	1036411	3	4	37	1	0	0	0	0	1	0	0	0	13042	913	32	3	917	3	RAD52	12	1036411	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	729276	1036411	132815484	214	3529										
VWF	7450	broad.mit.edu	37	chr12	6153567	6153567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcagcccgcaggttgtcagCgggacacaccagcttgacca	11	14	2	1	rs146892641		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:6153567C>T	ENST00000261405.5	-	18	2586	c.2332G>A	c.(2332-2334)Gct>Act	p.A778T		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	778	Amino-terminal.|TIL 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AGGTTGTCAGCGGGACACACC	0.562													16	30					0	0	1	0	0	T	6153567	C	T	6153567	3	4	37	1	0	0	0	0	1	0	0	0	17305	768	27	1	6249	1	VWF	12	6153567	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5117156	6153567	127698328	215	3530										
SPSB2	84727	broad.mit.edu	37	chr12	6981730	6981730	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggtcagtctgcagcggggcGagggccgtggccacgcccac	17	14	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:6981730G>T	ENST00000519357.1	-	2	522	c.336C>A	c.(334-336)ctC>ctA	p.L112L	SPSB2_ENST00000523102.1_Silent_p.L112L|SPSB2_ENST00000524270.1_Silent_p.L112L			Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box containing 2	112	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(2)|lung(2)|upper_aerodigestive_tract(1)	5						GCAGCGGGGCGAGGGCCGTGG	0.687											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	82					5.4927e-09	5.9436e-09	1	1	0	T	6981730	G	T	6981730	2	4	37	1	0	0	0	0	0	0	0	1	15168	1045	37	2		2	SPSB2	12	6981730	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	828163	6981730	126870165	216	3531										
FAM90A1	55138	broad.mit.edu	37	chr12	8375292	8375292	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctaagacggagcccctgtcaGacatttcggtagctgagcga	12	11	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:8375292G>C	ENST00000538603.1	-	7	1079	c.521C>G	c.(520-522)tCt>tGt	p.S174C	FAM90A1_ENST00000307435.6_Missense_Mutation_p.S174C	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	174							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GCCCCTGTCAGACATTTCGGT	0.572													5	95					0	0	1	0	0	C	8375292	G	C	8375292	3	2	37	1	0	0	0	0	1	0	0	0	5680	942	33	2	877	2	FAM90A1	12	8375292	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1393562	8375292	125476603	217	3532										
SLCO1C1	53919	broad.mit.edu	37	chr12	20905332	20905332	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tttaaagaaaaattatgtttCaaaacacagaagttttataa	4	3	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:20905332C>G	ENST00000266509.2	+	15	2377	c.2009C>G	c.(2008-2010)tCa>tGa	p.S670*	SLCO1C1_ENST00000381552.1_Missense_Mutation_p.F704L|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.F586L|SLCO1C1_ENST00000540354.1_Nonsense_Mutation_p.S621*|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.F704L	NM_017435.4	NP_059131.1	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	670					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					AATTATGTTTCAAAACACAGA	0.343													4	36					0	0	1	0	0	G	20905332	C	G	20905332	4	3	37	1	0	0	0	0	0	1	0	0	14779	838	29	2	2166	2	SLCO1C1	12	20905332	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	12530040	20905332	112946563	218	3533										
HDAC7	51564	broad.mit.edu	37	chr12	48189070	48189070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcaggggctctgagcgagtcCggctcagtggccagtggagg	19	10	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:48189070C>T	ENST00000080059.7	-	11	1180	c.1181G>A	c.(1180-1182)cGg>cAg	p.R394Q	HDAC7_ENST00000427332.2_Missense_Mutation_p.R355Q|HDAC7_ENST00000380610.4_Missense_Mutation_p.R411Q|HDAC7_ENST00000354334.3_Missense_Mutation_p.R357Q|HDAC7_ENST00000552960.1_Missense_Mutation_p.R377Q	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	355	Transcription repression 2 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		TGAGCGAGTCCGGCTCAGTGG	0.677													20	41					0	0	1	0	0	T	48189070	C	T	48189070	3	4	37	1	0	0	0	0	1	0	0	0	7052	652	23	1	1858	1	HDAC7	12	48189070	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	27283738	48189070	85662825	219	3534										
H1FNT	341567	broad.mit.edu	37	chr12	48723537	48723537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagccgcgccccggagctccCggaggcgccgccagcccctt	13	21	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:48723537C>T	ENST00000335017.1	+	1	775	c.463C>T	c.(463-465)Cgg>Tgg	p.R155W		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	155	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						CCGGAGCTCCCGGAGGCGCCG	0.711													6	11					0	0	1	0	0	T	48723537	C	T	48723537	3	4	37	1	0	0	0	0	1	0	0	0	6961	643	23	1	465	1	H1FNT	12	48723537	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	534467	48723537	85128358	220	3535										
FAM186B	84070	broad.mit.edu	37	chr12	49994908	49994908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gccagccctgccagaaggtgCgtttggacactgggacaggt	15	11	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:49994908C>T	ENST00000544141.1	-	4	844	c.245G>A	c.(244-246)cGc>cAc	p.R82H	FAM186B_ENST00000551047.1_Missense_Mutation_p.R172H|FAM186B_ENST00000257894.2_Missense_Mutation_p.R172H|PRPF40B_ENST00000508736.1_3'UTR			Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	172						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCAGAAGGTGCGTTTGGACAC	0.527													4	70					0	0	1	0	0	T	49994908	C	T	49994908	3	4	37	1	0	0	0	0	1	0	0	0	5542	768	27	1	2182	1	FAM186B	12	49994908	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1271371	49994908	83856987	221	3536										
KRT6B	3854	broad.mit.edu	37	chr12	52845724	52845724	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcctccacatgcgccacccaGgccaccactgcccctggagc	8	21	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:52845724G>C	ENST00000252252.3	-	1	186	c.139C>G	c.(139-141)Ctg>Gtg	p.L47V		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	47	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		GCGCCACCCAGGCCACCACTG	0.667													5	242					0	0	1	0	0	C	52845724	G	C	52845724	3	2	37	1	0	0	0	0	1	0	0	0	8523	991	35	5	1591	5	KRT6B	12	52845724	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2850816	52845724	81006171	222	3537										
OR6C6	283365	broad.mit.edu	37	chr12	55688184	55688184	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gatttagtaaaggggcaattGaggtatagagcaaagctaca	12	4	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:55688184G>T	ENST00000358433.2	-	1	832	c.833C>A	c.(832-834)tCa>tAa	p.S278*		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AGGGGCAATTGAGGTATAGAG	0.363													11	63					0.000978159	0.00101069	1	1	0	T	55688184	G	T	55688184	4	4	37	1	0	0	0	0	0	1	0	0	11240	1294	45	2	113	2	OR6C6	12	55688184	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2842460	55688184	78163711	223	3538										
DGKA	1606	broad.mit.edu	37	chr12	56347166	56347166	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccttcccatgcaaattgacgGagaaccctggatgcagacgc	10	13	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:56347166G>T	ENST00000331886.5	+	23	2550	c.2096G>T	c.(2095-2097)gGa>gTa	p.G699V	DGKA_ENST00000551156.1_Missense_Mutation_p.G699V|DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000394147.1_Missense_Mutation_p.G699V	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	699				G -> V (in Ref. 1; CAA44396).	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity	p.G699V(1)		breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	CAAATTGACGGAGAACCCTGG	0.468													25	372					5.61819e-17	6.18712e-17	1	1	0	T	56347166	G	T	56347166	3	4	37	1	0	0	0	0	1	0	0	0	4493	1174	41	2	2182	2	DGKA	12	56347166	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	658982	56347166	77504729	224	3539										
SMARCC2	6601	broad.mit.edu	37	chr12	56566438	56566438	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttttgcatgtctgttggtttCtctttgcctttgtcaggaaa	9	7	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:56566438C>T	ENST00000394023.3	-	19	1899	c.1794G>A	c.(1792-1794)gaG>gaA	p.E598E	SMARCC2_ENST00000347471.4_Silent_p.E598E|SMARCC2_ENST00000267064.4_Silent_p.E567E|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Silent_p.E598E	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	567	SANT.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CTGTTGGTTTCTCTTTGCCTT	0.498													13	131					0	0	1	0	0	T	56566438	C	T	56566438	2	4	37	1	0	0	0	0	0	0	0	1	14829	912	32	3		3	SMARCC2	12	56566438	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	219272	56566438	77285457	225	3540										
TIMELESS	8914	broad.mit.edu	37	chr12	56815774	56815774	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aggaacagtattcaggtgggCcaagatggcttccaccacat	11	10	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:56815774C>G	ENST00000229201.4	-	21	2702	c.2548G>C	c.(2548-2550)Gcc>Ccc	p.A850P	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.A851P	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	851					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TTCAGGTGGGCCAAGATGGCT	0.537													5	130					0	0	1	0	0	G	56815774	C	G	56815774	3	3	37	1	0	0	0	0	1	0	0	0	15963	739	26	5	1111	5	TIMELESS	12	56815774	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	249336	56815774	77036121	226	3541										
TIMELESS	8914	broad.mit.edu	37	chr12	56825346	56825346	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aaaatctgcactccgctcctGagctaagcgtccctgcccta	7	16	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:56825346G>C	ENST00000229201.4	-	8	881	c.727C>G	c.(727-729)Cag>Gag	p.Q243E	TIMELESS_ENST00000554616.1_Missense_Mutation_p.Q244E|TIMELESS_ENST00000553532.1_Missense_Mutation_p.Q244E	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	244					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						CTCCGCTCCTGAGCTAAGCGT	0.552													7	55					0	0	1	0	0	C	56825346	G	C	56825346	3	2	37	1	0	0	0	0	1	0	0	0	15963	1299	45	2	2984	2	TIMELESS	12	56825346	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	9572	56825346	77026549	227	3542										
TRHDE	29953	broad.mit.edu	37	chr12	72969145	72969145	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggaactggagattattaattGatcaattaatccggaatcat	8	5	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:72969145G>C	ENST00000261180.4	+	11	2203	c.2107G>C	c.(2107-2109)Gat>Cat	p.D703H	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	703					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						ATTATTAATTGATCAATTAAT	0.343													10	46					0	0	1	0	0	C	72969145	G	C	72969145	3	2	37	1	0	0	0	0	1	0	0	0	16539	1290	45	2	2149	2	TRHDE	12	72969145	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	16143799	72969145	60882750	228	3543										
NAV3	89795	broad.mit.edu	37	chr12	78400500	78400500	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcaagctagtcaatgcccgGactgctttacgccccccgca	8	16	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:78400500G>T	ENST00000397909.2	+	8	1355	c.1182G>T	c.(1180-1182)cgG>cgT	p.R394R	NAV3_ENST00000228327.6_Silent_p.R394R|NAV3_ENST00000266692.7_Silent_p.R394R|NAV3_ENST00000536525.2_Silent_p.R394R			Q8IVL0	NAV3_HUMAN	neuron navigator 3	394						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAATGCCCGGACTGCTTTAC	0.498										HNSCC(70;0.22)			10	110					7.48243e-07	7.95808e-07	1	1	0	T	78400500	G	T	78400500	2	4	37	1	0	0	0	0	0	0	0	1	10232	1161	41	2		2	NAV3	12	78400500	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	5431355	78400500	55451395	229	3544										
LRRIQ1	84125	broad.mit.edu	37	chr12	85450933	85450933	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggataaactggaaattcttCgatgtggcccttgggatact	11	7	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:85450933C>T	ENST00000393217.2	+	8	2423	c.2362C>T	c.(2362-2364)Cga>Tga	p.R788*		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	788								p.R788*(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GGAAATTCTTCGATGTGGCCC	0.323													11	149					0	0	1	0	0	T	85450933	C	T	85450933	4	4	37	1	0	0	0	0	0	1	0	0	9073	876	31	1	2388	1	LRRIQ1	12	85450933	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	7050433	85450933	48400962	230	3545										
CRY1	1407	broad.mit.edu	37	chr12	107398927	107398927	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgaaattcttacaatgacttCtactccagcttcagttgcca	5	11	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:107398927C>G	ENST00000008527.5	-	3	1234	c.367G>C	c.(367-369)Gaa>Caa	p.E123Q		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	123	DNA photolyase.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						ACAATGACTTCTACTCCAGCT	0.348													8	61					0	0	1	0	0	G	107398927	C	G	107398927	3	3	37	1	0	0	0	0	1	0	0	0	3926	922	32	2	1433	2	CRY1	12	107398927	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	21947994	107398927	26452968	231	3546										
HVCN1	84329	broad.mit.edu	37	chr12	111099146	111099146	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcctcttcattctcccatttCttgtagttgatgttccaggc	6	12	4	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:111099146C>G	ENST00000356742.5	-	3	882	c.129G>C	c.(127-129)aaG>aaC	p.K43N	HVCN1_ENST00000439744.2_Missense_Mutation_p.K23N|HVCN1_ENST00000548312.1_Missense_Mutation_p.K43N|HVCN1_ENST00000242607.8_Missense_Mutation_p.K43N			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	43					response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						tctccCATTTCTTGTAGTTGA	0.597													7	65					0	0	1	0	0	G	111099146	C	G	111099146	3	3	37	1	0	0	0	0	1	0	0	0	7505	912	32	2	712	2	HVCN1	12	111099146	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3700219	111099146	22752749	232	3547										
SH2B3	10019	broad.mit.edu	37	chr12	111886103	111886103	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gacaatcagtacacacctctCtgaccagtgaggaattccag	8	12	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:111886103C>A	ENST00000341259.2	+	8	2082	c.1725C>A	c.(1723-1725)ctC>ctA	p.L575L	SH2B3_ENST00000538307.1_Silent_p.L373L	NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	575					blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						ACACACCTCTCTGACCAGTGA	0.532													4	30					0.150653	0.151001	1	1	0	A	111886103	C	A	111886103	2	1	37	1	0	0	0	0	0	0	0	1	14282	900	32	2		2	SH2B3	12	111886103	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	786957	111886103	21965792	233	3548										
ATXN2	6311	broad.mit.edu	37	chr12	111963105	111963105	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcactttagcactgatagcaGagtcagtaaaagcatctgca	8	9	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:111963105G>C	ENST00000377617.3	-	6	1228	c.1067C>G	c.(1066-1068)tCt>tGt	p.S356C	ATXN2_ENST00000550104.1_Missense_Mutation_p.S356C|ATXN2_ENST00000542287.2_Missense_Mutation_p.S91C|ATXN2_ENST00000535949.1_Missense_Mutation_p.S67C|ATXN2_ENST00000549455.1_5'UTR|ATXN2_ENST00000389153.4_Missense_Mutation_p.S91C	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	356					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						ACTGATAGCAGAGTCAGTAAA	0.428													7	78					0	0	1	0	0	C	111963105	G	C	111963105	3	2	37	1	0	0	0	0	1	0	0	0	1209	942	33	2	2954	2	ATXN2	12	111963105	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	77002	111963105	21888790	234	3549										
MED13L	23389	broad.mit.edu	37	chr12	116413008	116413008	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	catggccaagacgcccaagtCgcccgattacaactctccag	8	16	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:116413008C>T	ENST00000281928.3	-	25	5905	c.5699G>A	c.(5698-5700)cGa>cAa	p.R1900Q		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1900					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ACGCCCAAGTCGCCCGATTAC	0.438													5	78					0	0	1	0	0	T	116413008	C	T	116413008	3	4	37	1	0	0	0	0	1	0	0	0	9480	884	31	1	961	1	MED13L	12	116413008	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4449903	116413008	17438887	235	3550										
MED13L	23389	broad.mit.edu	37	chr12	116460310	116460310	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atgtgtatatgctcctcattGatcaaataaattggctggtg	9	6	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:116460310G>A	ENST00000281928.3	-	5	782	c.576C>T	c.(574-576)atC>atT	p.I192I		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	192					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GCTCCTCATTGATCAAATAAA	0.463													4	24					0	0	1	0	0	A	116460310	G	A	116460310	2	1	37	1	0	0	0	0	0	0	0	1	9480	1280	45	3		3	MED13L	12	116460310	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	47302	116460310	17391585	236	3551										
P2RX7	5027	broad.mit.edu	37	chr12	121570869	121570869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatggcaccattaagtggttCttccacgtgatcatcttttc	7	10	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:121570869C>T	ENST00000546057.1	+	1	239	c.96C>T	c.(94-96)ttC>ttT	p.F32F	P2RX7_ENST00000377162.2_Silent_p.F32F|P2RX7_ENST00000328963.5_5'UTR|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_5'UTR|P2RX7_ENST00000541446.1_5'UTR	NM_002562.5	NP_002553.3	A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	32						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTAAGTGGTTCTTCCACGTGA	0.527													10	139					0	0	1	0	0	T	121570869	C	T	121570869	2	4	37	1	0	0	0	0	0	0	0	1	11391	912	32	3		3	P2RX7	12	121570869	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5110559	121570869	12281026	237	3552										
CCDC92	80212	broad.mit.edu	37	chr12	124422324	124422324	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctctttcactttcagttgggCttccagctcttcacatcttt	5	13	6	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:124422324C>T	ENST00000545135.1	-	3	3522	c.226G>A	c.(226-228)Gcc>Acc	p.A76T	CCDC92_ENST00000544798.1_Intron|CCDC92_ENST00000545891.1_Missense_Mutation_p.A76T|CCDC92_ENST00000238156.3_Missense_Mutation_p.A93T			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	93										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		TTCAGTTGGGCTTCCAGCTCT	0.443													10	156					0	0	1	0	0	T	124422324	C	T	124422324	3	4	37	1	0	0	0	0	1	0	0	0	2891	797	28	3	722	3	CCDC92	12	124422324	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2851455	124422324	9429571	238	3553										
ANKLE2	23141	broad.mit.edu	37	chr12	133331678	133331678	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tctaaggtcatctggattcaGaagtttcaatcgagccaaca	8	9	5	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr12:133331678G>C	ENST00000539605.1	-	1	6721	c.37C>G	c.(37-39)Ctg>Gtg	p.L13V	ANKLE2_ENST00000337516.5_Missense_Mutation_p.L75V|ANKLE2_ENST00000357997.5_Missense_Mutation_p.L75V			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	75						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TCTGGATTCAGAAGTTTCAAT	0.403													10	97					0	0	1	0	0	C	133331678	G	C	133331678	3	2	37	1	0	0	0	0	1	0	0	0	629	933	33	2	2641	2	ANKLE2	12	133331678	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	8909354	133331678	520217	239	3554										
C1QTNF9	338872	broad.mit.edu	37	chr13	24895247	24895247	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccatgggagagaagggcctcCgaggagagactgggcctcag	17	10	1	2	rs140002881		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr13:24895247C>T	ENST00000382071.2	+	4	428	c.343C>T	c.(343-345)Cga>Tga	p.R115*	C1QTNF9_ENST00000332018.4_Nonsense_Mutation_p.R115*|C1QTNF9-AS1_ENST00000449656.1_RNA			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	115	Collagen-like 2.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		GAAGGGCCTCCGAGGAGAGAC	0.602													17	50					0	0	1	0	0	T	24895247	C	T	24895247	4	4	37	1	0	0	0	0	0	1	0	0	1983	644	23	1	353	1	C1QTNF9	13	24895247	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08		24895247	90274631	240	3555										
LECT1	11061	broad.mit.edu	37	chr13	53282685	53282685	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acgcacatgataaggattatCaggattgaaggcttgtgagt	12	5	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr13:53282685C>T	ENST00000448904.2	-	6	885	c.775G>A	c.(775-777)Gat>Aat	p.D259N	LECT1_ENST00000377962.3_Missense_Mutation_p.D259N	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	259					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		TAAGGATTATCAGGATTGAAG	0.483													4	25					0	0	1	0	0	T	53282685	C	T	53282685	3	4	37	1	0	0	0	0	1	0	0	0	8750	826	29	3	237	3	LECT1	13	53282685	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	28387438	53282685	61887193	241	3556										
SLITRK5	26050	broad.mit.edu	37	chr13	88328522	88328522	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agacttatttctgactacgaGatgaggccgcagacgccttt	10	10	1	5			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr13:88328522G>C	ENST00000325089.6	+	2	1098	c.879G>C	c.(877-879)gaG>gaC	p.E293D	SLITRK5_ENST00000400028.3_Missense_Mutation_p.E52D	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	293						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CTGACTACGAGATGAGGCCGC	0.537													15	95					0	0	1	0	0	C	88328522	G	C	88328522	3	2	37	1	0	0	0	0	1	0	0	0	14799	933	33	2	881	2	SLITRK5	13	88328522	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	35045837	88328522	26841356	242	3557										
OR4K5	79317	broad.mit.edu	37	chr14	20389101	20389101	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctttttactggaggggagatGgtgctacttgtttcgatggc	14	6	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:20389101G>T	ENST00000315915.4	+	1	361	c.336G>T	c.(334-336)atG>atT	p.M112I		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAGGGGAGATGGTGCTACTTG	0.428													11	252					7.03913e-09	7.57926e-09	1	1	0	T	20389101	G	T	20389101	3	4	37	1	0	0	0	0	1	0	0	0	11120	1348	47	5	338	5	OR4K5	14	20389101	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		20389101	86960439	243	3558										
FAM179B	23116	broad.mit.edu	37	chr14	45432775	45432775	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggtgctgggaaaatttaaccCtagttctactcctcattcta	7	10	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:45432775C>G	ENST00000361462.2	+	1	1334	c.1151C>G	c.(1150-1152)cCt>cGt	p.P384R	FAM179B_ENST00000382233.2_Missense_Mutation_p.P384R|FAM179B_ENST00000361577.3_Missense_Mutation_p.P384R			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	384							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						AAATTTAACCCTAGTTCTACT	0.423													4	65					0	0	1	0	0	G	45432775	C	G	45432775	3	3	37	1	0	0	0	0	1	0	0	0	5535	681	24	5	1153	5	FAM179B	14	45432775	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	25043674	45432775	61916765	244	3559										
FANCM	57697	broad.mit.edu	37	chr14	45642401	45642401	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atgcaaatgatagagggaatGagacacgaagaggtggggtt	16	3	0	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:45642401G>A	ENST00000267430.5	+	13	2389	c.2304G>A	c.(2302-2304)atG>atA	p.M768I	FANCM_ENST00000542564.2_Missense_Mutation_p.M742I	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	768					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TAGAGGGAATGAGACACGAAG	0.373								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	47					0	0	1	0	0	A	45642401	G	A	45642401	3	1	37	1	0	0	0	0	1	0	0	0	5703	1290	45	3	2354	3	FANCM	14	45642401	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	209626	45642401	61707139	245	3560										
FANCM	57697	broad.mit.edu	37	chr14	45665636	45665636	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggtggtggaaaggaggtctCaatctgagatgttaaatagt	14	3	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:45665636C>G	ENST00000267430.5	+	21	5687	c.5602C>G	c.(5602-5604)Caa>Gaa	p.Q1868E	FANCM_ENST00000542564.2_Missense_Mutation_p.Q1842E	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1868	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						AAGGAGGTCTCAATCTGAGAT	0.403								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				8	66					0	0	1	0	0	G	45665636	C	G	45665636	3	3	37	1	0	0	0	0	1	0	0	0	5703	827	29	2	5684	2	FANCM	14	45665636	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	23235	45665636	61683904	246	3561										
SLC8A3	6547	broad.mit.edu	37	chr14	70633450	70633450	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttctactgtcctaaaggggaCgatgactgtaccccgggcac	11	12	1	1	rs76086886	by1000genomes	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:70633450C>T	ENST00000381269.2	-	2	2443	c.1690G>A	c.(1690-1692)Gtc>Atc	p.V564I	SLC8A3_ENST00000357887.3_Missense_Mutation_p.V564I|SLC8A3_ENST00000534137.1_Missense_Mutation_p.V564I|SLC8A3_ENST00000528359.1_Missense_Mutation_p.V564I|SLC8A3_ENST00000356921.2_Missense_Mutation_p.V564I	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	564	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CTAAAGGGGACGATGACTGTA	0.468													9	49					0	0	1	0	0	T	70633450	C	T	70633450	3	4	37	1	0	0	0	0	1	0	0	0	14762	536	19	1	1232	1	SLC8A3	14	70633450	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	24967814	70633450	36716090	247	3562										
ALDH6A1	4329	broad.mit.edu	37	chr14	74534271	74534271	+	Splice_Site	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctaccccatggttcttggctCcctaaaaaaaaatgcagaaa	6	11	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:74534271C>A	ENST00000553458.1	-	8	952	c.852_splice	c.e8-1	p.G285_splice	ALDH6A1_ENST00000555126.1_Splice_Site_p.G2_splice|CCDC176_ENST00000553773.1_Intron|ALDH6A1_ENST00000350259.4_Splice_Site_p.G272_splice|AC005484.5_ENST00000492026.1_RNA	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	285						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	GTTCTTGGCTCCCTAAAAAAA	0.478													4	31					2.56e-06	2.69637e-06	1	1	0	A	74534271	C	A	74534271	5	1	37	1	0	0	0	0	0	0	1	0	500	869	30	2	773	2	ALDH6A1	14	74534271	Splice_Site	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3900821	74534271	32815269	248	3563										
VSX2	338917	broad.mit.edu	37	chr14	74707950	74707950	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctttaaaccagaccaagaaaCggaagaagcggcgacacagg	11	10	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:74707950C>T	ENST00000261980.2	+	2	526	c.436C>T	c.(436-438)Cgg>Tgg	p.R146W		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	146					multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		GACCAAGAAACGGAAGAAGCG	0.587													7	50					0	0	1	0	0	T	74707950	C	T	74707950	3	4	37	1	0	0	0	0	1	0	0	0	17291	527	19	1	442	1	VSX2	14	74707950	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	173679	74707950	32641590	249	3564										
ESRRB	2103	broad.mit.edu	37	chr14	76928925	76928925	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgcccggccaccaacgagtgCgagatcaccaaacggaggcg	13	14	1	1	rs1064439		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:76928925C>T	ENST00000380887.2	+	3	507	c.435C>T	c.(433-435)tgC>tgT	p.C145C	ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000556177.1_Silent_p.C145C|ESRRB_ENST00000261532.7_Silent_p.C145C|ESRRB_ENST00000509242.1_Silent_p.C145C			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	145						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CCAACGAGTGCGAGATCACCA	0.632													22	51					0	0	1	0	0	T	76928925	C	T	76928925	2	4	37	1	0	0	0	0	0	0	0	1	5289	776	27	1		1	ESRRB	14	76928925	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2220975	76928925	30420615	250	3565										
TECPR2	9895	broad.mit.edu	37	chr14	102906847	102906847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aagtcaccatcaaggggaagCggcactggtacgaagccctg	13	11	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr14:102906847C>T	ENST00000359520.7	+	11	2879	c.2653C>T	c.(2653-2655)Cgg>Tgg	p.R885W	TECPR2_ENST00000558678.1_Missense_Mutation_p.R885W	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	885							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CAAGGGGAAGCGGCACTGGTA	0.517													11	80					0	0	1	0	0	T	102906847	C	T	102906847	3	4	37	1	0	0	0	0	1	0	0	0	15802	759	27	1	2691	1	TECPR2	14	102906847	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	25977922	102906847	4442693	251	3566										
TRPM1	4308	broad.mit.edu	37	chr15	31323322	31323322	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	actccgaaactcatgagcacGaccagcatgatgaccacaaa	7	13	1	3	rs115529590	by1000genomes	TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:31323322G>A	ENST00000542188.1	-	22	3355	c.3042C>T	c.(3040-3042)gtC>gtT	p.V1014V	TRPM1_ENST00000397795.2_Silent_p.V975V|RP11-348B17.1_ENST00000561299.1_RNA|RP11-348B17.1_ENST00000558755.1_RNA|TRPM1_ENST00000256552.6_Silent_p.V997V	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	975					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCATGAGCACGACCAGCATGA	0.512													11	56					0	0	1	0	0	A	31323322	G	A	31323322	2	1	37	1	0	0	0	0	0	0	0	1	16645	1045	37	1		1	TRPM1	15	31323322	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		31323322	71208070	252	3567										
AVEN	57099	broad.mit.edu	37	chr15	34159950	34159950	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagatttcagctcaaagatgGgcccccttcctccaggcccc	8	17	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:34159950G>A	ENST00000306730.3	-	5	848	c.719C>T	c.(718-720)cCc>cTc	p.P240L		NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	240					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		CTCAAAGATGGGCCCCCTTCC	0.547													6	84					0	0	1	0	0	A	34159950	G	A	34159950	3	1	37	1	0	0	0	0	1	0	0	0	1224	1232	43	3	377	3	AVEN	15	34159950	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2836628	34159950	68371442	253	3568										
MGA	23269	broad.mit.edu	37	chr15	42021388	42021388	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gaagaggacaaagatccagtCtacttgtactttgaaagtat	9	6	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:42021388C>T	ENST00000219905.7	+	11	3865	c.3684C>T	c.(3682-3684)gtC>gtT	p.V1228V	MGA_ENST00000566586.1_Silent_p.V1228V|MGA_ENST00000545763.1_Silent_p.V1228V|MGA_ENST00000570161.1_Silent_p.V1228V|MGA_ENST00000389936.4_Silent_p.V1228V	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1228						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.V1228V(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AAGATCCAGTCTACTTGTACT	0.408													5	14					0	0	1	0	0	T	42021388	C	T	42021388	2	4	37	1	0	0	0	0	0	0	0	1	9589	900	32	3		3	MGA	15	42021388	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	7861438	42021388	60510004	254	3569										
SPG11	80208	broad.mit.edu	37	chr15	44876090	44876090	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttgtaggagagcatggatctCtgggtgcagatcctccatac	12	9	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:44876090C>T	ENST00000261866.7	-	30	5804	c.5788G>A	c.(5788-5790)Gag>Aag	p.E1930K	SPG11_ENST00000427534.2_Missense_Mutation_p.E1930K|SPG11_ENST00000558319.1_Missense_Mutation_p.E1930K|SPG11_ENST00000535302.2_Missense_Mutation_p.E1930K	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1930					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GCATGGATCTCTGGGTGCAGA	0.498													27	70					0	0	1	0	0	T	44876090	C	T	44876090	3	4	37	1	0	0	0	0	1	0	0	0	15096	922	32	3	1587	3	SPG11	15	44876090	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2854702	44876090	57655302	255	3570										
DUOX1	53905	broad.mit.edu	37	chr15	45455856	45455856	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tctacatcacccagctggctGagaagttcgacctcaggacc	9	14	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:45455856G>A	ENST00000321429.4	+	33	4782	c.4375G>A	c.(4375-4377)Gag>Aag	p.E1459K	CTD-2651B20.1_ENST00000558039.1_lincRNA|DUOX1_ENST00000561166.1_Missense_Mutation_p.E1105K|DUOX1_ENST00000389037.3_Missense_Mutation_p.E1459K	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	1459					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CCAGCTGGCTGAGAAGTTCGA	0.577											OREG0023103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	149					0	0	1	0	0	A	45455856	G	A	45455856	3	1	37	1	0	0	0	0	1	0	0	0	4826	1291	45	3	4497	3	DUOX1	15	45455856	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	579766	45455856	57075536	256	3571										
SEMA6D	80031	broad.mit.edu	37	chr15	48058076	48058076	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cacaaaataggtgcagtgctGagaatgaggaagacaaaaag	12	5	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:48058076G>A	ENST00000316364.5	+	14	1877	c.1438G>A	c.(1438-1440)Gag>Aag	p.E480K	SEMA6D_ENST00000355997.3_Missense_Mutation_p.E480K|SEMA6D_ENST00000358066.4_Missense_Mutation_p.E480K|SEMA6D_ENST00000389432.2_Missense_Mutation_p.E480K|SEMA6D_ENST00000389428.3_Missense_Mutation_p.E480K|SEMA6D_ENST00000537942.1_Missense_Mutation_p.E480K|SEMA6D_ENST00000558816.1_Missense_Mutation_p.E480K|SEMA6D_ENST00000536845.2_Missense_Mutation_p.E480K|SEMA6D_ENST00000389433.2_Missense_Mutation_p.E480K|SEMA6D_ENST00000558014.1_Missense_Mutation_p.E480K|SEMA6D_ENST00000354744.4_Missense_Mutation_p.E480K	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	480	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GTGCAGTGCTGAGAATGAGGA	0.423													13	81					0	0	1	0	0	A	48058076	G	A	48058076	3	1	37	1	0	0	0	0	1	0	0	0	14095	1291	45	3	1492	3	SEMA6D	15	48058076	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2602220	48058076	54473316	257	3572										
GNB5	0	broad.mit.edu	37	chr15	52416726	52416726	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agtcccatcgggggaaactcGtagagtgctaacgcggtttt	13	9	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:52416726G>A	ENST00000261837.7	-	12	1185	c.1120C>T	c.(1120-1122)Cga>Tga	p.R374*	GNB5_ENST00000559348.1_5'UTR|GNB5_ENST00000358784.7_Nonsense_Mutation_p.R332*|GNB5_ENST00000396335.4_Nonsense_Mutation_p.R262*	NM_016194.3	NP_057278.2	O14775	GBB5_HUMAN	guanine nucleotide binding protein (G protein), beta 5	374						heterotrimeric G-protein complex	GTPase activity|signal transducer activity			large_intestine(1)|lung(1)	2				all cancers(107;0.0163)		GGGGAAACTCGTAGAGTGCTA	0.488													7	121					0	0	1	0	0	A	52416726	G	A	52416726	4	1	37	1	0	0	0	0	0	1	0	0	6562	1153	40	1	75	1	GNB5	15	52416726	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4358650	52416726	50114666	258	3573										
MYO5C	55930	broad.mit.edu	37	chr15	52511996	52511996	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctcttgactgcgatgtaactGattagacaattcttctagtt	7	8	3	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:52511996G>C	ENST00000261839.7	-	31	3906	c.3745C>G	c.(3745-3747)Cag>Gag	p.Q1249E		NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1249						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		CGATGTAACTGATTAGACAAT	0.378													9	19					0	0	1	0	0	C	52511996	G	C	52511996	3	2	37	1	0	0	0	0	1	0	0	0	10127	1299	45	2	1527	2	MYO5C	15	52511996	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	95270	52511996	50019396	259	3574										
RNF111	54778	broad.mit.edu	37	chr15	59373350	59373350	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gtacagctgcaccaatccctCagcatcttcctcctacacac	4	18	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:59373350C>A	ENST00000348370.4	+	8	2597	c.2164C>A	c.(2164-2166)Cag>Aag	p.Q722K	RNF111_ENST00000557998.1_Missense_Mutation_p.Q722K|RNF111_ENST00000561186.1_Missense_Mutation_p.Q722K|RNF111_ENST00000559209.1_Missense_Mutation_p.Q722K|RNF111_ENST00000434298.1_Missense_Mutation_p.Q722K	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	722	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.Q722*(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		ACCAATCCCTCAGCATCTTCC	0.502													16	116					1.3612e-06	1.44069e-06	1	1	0	A	59373350	C	A	59373350	3	1	37	1	0	0	0	0	1	0	0	0	13476	827	29	2	2190	2	RNF111	15	59373350	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6861354	59373350	43158042	260	3575										
HDGFRP3	0	broad.mit.edu	37	chr15	83826306	83826306	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cttctccctcagtttctgaaGagctctgttgctgaattgcc	8	12	4	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr15:83826306G>A	ENST00000299633.4	-	4	923	c.320C>T	c.(319-321)tCt>tTt	p.S107F		NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		107					cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						AGTTTCTGAAGAGCTCTGTTG	0.348													6	22					0	0	1	0	0	A	83826306	G	A	83826306	3	1	37	1	0	0	0	0	1	0	0	0	7061	942	33	3	303	3	HDGFRP3	15	83826306	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	24452956	83826306	18705086	261	3576										
CACNA1H	8912	broad.mit.edu	37	chr16	1261782	1261782	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acatcatgtacgacgggctgGatgccgtgggtgtcgaccag	15	10	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:1261782G>C	ENST00000348261.5	+	24	4791	c.4543G>C	c.(4543-4545)Gat>Cat	p.D1515H	CACNA1H_ENST00000358590.4_Missense_Mutation_p.D1515H|CACNA1H_ENST00000565831.1_Missense_Mutation_p.D1515H	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1515					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGACGGGCTGGATGCCGTGGG	0.662													8	73					0	0	1	0	0	C	1261782	G	C	1261782	3	2	37	1	0	0	0	0	1	0	0	0	2563	1174	41	2	4633	2	CACNA1H	16	1261782	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		1261782	89092971	262	3577										
CHD9	80205	broad.mit.edu	37	chr16	53340214	53340214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cactgagcactacccaggatGagactcaggatagttttcag	10	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:53340214G>A	ENST00000566029.1	+	32	6894	c.6685G>A	c.(6685-6687)Gag>Aag	p.E2229K	CHD9_ENST00000447540.1_Missense_Mutation_p.E2230K|CHD9_ENST00000564845.1_Missense_Mutation_p.E2229K|CHD9_ENST00000398510.3_Missense_Mutation_p.E2229K			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2229					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TACCCAGGATGAGACTCAGGA	0.398													4	38					0	0	1	0	0	A	53340214	G	A	53340214	3	1	37	1	0	0	0	0	1	0	0	0	3354	1291	45	3	6807	3	CHD9	16	53340214	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	52078432	53340214	37014539	263	3578										
CPNE2	221184	broad.mit.edu	37	chr16	57180017	57180017	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagtacttcatcctcctcatCatcacggacggggtcatcag	8	14	6	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:57180017C>T	ENST00000535318.2	+	16	1684	c.1323C>T	c.(1321-1323)atC>atT	p.I441I	CPNE2_ENST00000565874.1_Silent_p.I441I|CPNE2_ENST00000537605.1_Silent_p.I339I|CPNE2_ENST00000565951.1_3'UTR|CPNE2_ENST00000290776.8_Silent_p.I441I			Q96FN4	CPNE2_HUMAN	copine II	441	VWFA.									central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				TCCTCCTCATCATCACGGACG	0.612													3	15					0	0	1	0	0	T	57180017	C	T	57180017	2	4	37	1	0	0	0	0	0	0	0	1	3835	816	29	3		3	CPNE2	16	57180017	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3839803	57180017	33174736	264	3579										
COG4	25839	broad.mit.edu	37	chr16	70548413	70548413	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atggcctgatagaggcggttCtgcaaaaagatttggtactt	12	6	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:70548413C>T	ENST00000323786.5	-	4	391		c.e4-1		COG4_ENST00000564653.1_Splice_Site|COG4_ENST00000393612.4_Splice_Site	NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4						Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				AGAGGCGGTTCTGCAAAAAGA	0.433													6	19					0	0	1	0	0	T	70548413	C	T	70548413	5	4	37	1	0	0	0	0	0	0	1	0	3683	927	32	3	2064	3	COG4	16	70548413	Splice_Site	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	13368396	70548413	19806340	265	3580										
ZNF821	55565	broad.mit.edu	37	chr16	71898077	71898077	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcaactgctcccggctcccGcagtctagctggcagagggg	13	14	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:71898077G>A	ENST00000425432.1	-	6	760	c.381C>T	c.(379-381)tgC>tgT	p.C127C	RP11-498D10.4_ENST00000569119.1_Intron|ZNF821_ENST00000564943.1_5'UTR|ZNF821_ENST00000313565.6_Silent_p.C85C|ZNF821_ENST00000446827.2_Silent_p.C85C|ZNF821_ENST00000565601.1_Silent_p.C127C|ZNF821_ENST00000564134.1_Silent_p.C126C|RP11-498D10.4_ENST00000568581.1_Intron	NM_001201552.1	NP_001188481.1	O75541	ZN821_HUMAN	zinc finger protein 821	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(2)	13						CCCGGCTCCCGCAGTCTAGCT	0.532													13	71					0	0	1	0	0	A	71898077	G	A	71898077	2	1	37	1	0	0	0	0	0	0	0	1	18224	1079	38	1		1	ZNF821	16	71898077	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1349664	71898077	18456676	266	3581										
VAT1L	57687	broad.mit.edu	37	chr16	77859228	77859228	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggagtttgtctacaagatccCggatgacatgagcttctccg	11	10	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:77859228C>T	ENST00000302536.2	+	3	602	c.449C>T	c.(448-450)cCg>cTg	p.P150L		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	150							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TACAAGATCCCGGATGACATG	0.522													14	28					0	0	1	0	0	T	77859228	C	T	77859228	3	4	37	1	0	0	0	0	1	0	0	0	17189	652	23	1	459	1	VAT1L	16	77859228	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5961151	77859228	12495525	267	3582										
CTU2	348180	broad.mit.edu	37	chr16	88780614	88780614	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gctgcagacccagttcccctCcactgtcagcactgtgtaca	8	16	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr16:88780614C>T	ENST00000567949.1	+	10	1298	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F	CTU2_ENST00000453996.2_Missense_Mutation_p.S359F|CTU2_ENST00000312060.5_Missense_Mutation_p.S359F|CTU2_ENST00000378384.3_Missense_Mutation_p.S272F			Q2VPK5	CTU2_HUMAN	cytosolic thiouridylase subunit 2 homolog (S. pombe)	359					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			NS(1)|breast(1)|endometrium(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11						CAGTTCCCCTCCACTGTCAGC	0.627													8	58					0	0	1	0	0	T	88780614	C	T	88780614	3	4	37	1	0	0	0	0	1	0	0	0	4071	855	30	3	1114	3	CTU2	16	88780614	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10921386	88780614	1574139	268	3583										
PRPF8	10594	broad.mit.edu	37	chr17	1563262	1563262	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgtctccttttgtactgtctCaatttccagtgcatcaagtt	6	10	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:1563262C>G	ENST00000572621.1	-	30	5084	c.4819G>C	c.(4819-4821)Gag>Cag	p.E1607Q	PRPF8_ENST00000304992.6_Missense_Mutation_p.E1607Q			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1607						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGTACTGTCTCAATTTCCAGT	0.403													6	73					0	0	1	0	0	G	1563262	C	G	1563262	3	3	37	1	0	0	0	0	1	0	0	0	12626	835	29	2	2240	2	PRPF8	17	1563262	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08		1563262	79631948	269	3584										
MNT	4335	broad.mit.edu	37	chr17	2303970	2303970	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttgctgcgcttgccattccaGgaagcgggccgcctccagta	12	14	0	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:2303970G>A	ENST00000174618.4	-	1	442	c.37C>T	c.(37-39)Ctg>Ttg	p.L13L		NM_020310.2	NP_064706.1	Q99583	MNT_HUMAN	MAX network transcriptional repressor	13					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			endometrium(4)|large_intestine(5)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	12				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		TGCCATTCCAGGAAGCGGGCC	0.731													9	3					0	0	1	0	0	A	2303970	G	A	2303970	2	1	37	1	0	0	0	0	0	0	0	1	9726	991	35	3		3	MNT	17	2303970	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	740708	2303970	78891240	270	3585										
KIAA0753	9851	broad.mit.edu	37	chr17	6499537	6499537	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgggctatccttgctgtcctCaacggtggctaaggtttcag	12	10	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:6499537C>A	ENST00000361413.3	-	15	2657	c.2299G>T	c.(2299-2301)Gag>Tag	p.E767*	KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000542606.1_Nonsense_Mutation_p.E468*|KIAA0753_ENST00000589033.1_Nonsense_Mutation_p.E223*|KIAA0753_ENST00000572370.1_Nonsense_Mutation_p.E468*	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	767						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TTGCTGTCCTCAACGGTGGCT	0.522													18	135					2.35188e-11	2.56408e-11	1	1	0	A	6499537	C	A	6499537	4	1	37	1	0	0	0	0	0	1	0	0	8232	835	29	2	624	2	KIAA0753	17	6499537	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4195567	6499537	74695673	271	3586										
KIAA0753	9851	broad.mit.edu	37	chr17	6502580	6502580	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctgtgcaggctgggctttcgCtgtgtttactgacgagccat	13	10	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:6502580C>G	ENST00000361413.3	-	14	2507	c.2149G>C	c.(2149-2151)Gcg>Ccg	p.A717P	KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000542606.1_Missense_Mutation_p.A418P|KIAA0753_ENST00000589033.1_Missense_Mutation_p.A173P|KIAA0753_ENST00000572370.1_Missense_Mutation_p.A418P	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	717						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TGGGCTTTCGCTGTGTTTACT	0.358													5	38					0	0	1	0	0	G	6502580	C	G	6502580	3	3	37	1	0	0	0	0	1	0	0	0	8232	797	28	5	778	5	KIAA0753	17	6502580	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	3043	6502580	74692630	272	3587										
KIAA0753	9851	broad.mit.edu	37	chr17	6502605	6502605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tttactgacgagccatctttCaaatgaatatttgcttctgt	6	8	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:6502605C>G	ENST00000361413.3	-	14	2482	c.2124G>C	c.(2122-2124)ttG>ttC	p.L708F	KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000542606.1_Missense_Mutation_p.L409F|KIAA0753_ENST00000589033.1_Missense_Mutation_p.L164F|KIAA0753_ENST00000572370.1_Missense_Mutation_p.L409F	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	708						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		AGCCATCTTTCAAATGAATAT	0.363													5	34					0	0	1	0	0	G	6502605	C	G	6502605	3	3	37	1	0	0	0	0	1	0	0	0	8232	825	29	2	803	2	KIAA0753	17	6502605	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	25	6502605	74692605	273	3588										
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	8	16	1	0	rs121913343		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:7577121G>A	ENST00000420246.2	-	8	949	c.817C>T	c.(817-819)Cgt>Tgt	p.R273C	TP53_ENST00000269305.4_Missense_Mutation_p.R273C|TP53_ENST00000359597.4_Missense_Mutation_p.R273C|TP53_ENST00000455263.2_Missense_Mutation_p.R273C|TP53_ENST00000445888.2_Missense_Mutation_p.R273C|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273C(481)|p.R273S(16)|p.R273G(9)|p.0?(8)|p.?(2)|p.R273fs*72(2)|p.R273fs*33(2)|p.R273fs*32(2)|p.V272>?(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(MFE319_ENDOMETRIUM)|R273C(NCIH1048_LUNG)|R273C(PANC0213_PANCREAS)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(RH30_SOFT_TISSUE)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SH10TC_STOMACH)|R273C(SJRH30_SOFT_TISSUE)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(TT2609C02_THYROID)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	22					0	0	1	0	0	A	7577121	G	A	7577121	3	1	37	1	0	0	0	0	1	0	0	0	16441	1087	38	1	469	1	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1074516	7577121	73618089	274	3589										
TP53	7157	broad.mit.edu	37	chr17	7578534	7578534	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttggccagttggcaaaacatCttgttgagggcaggggagta	15	6	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:7578534C>A	ENST00000420246.2	-	5	528	c.396G>T	c.(394-396)aaG>aaT	p.K132N	TP53_ENST00000269305.4_Missense_Mutation_p.K132N|TP53_ENST00000359597.4_Missense_Mutation_p.K132N|TP53_ENST00000455263.2_Missense_Mutation_p.K132N|TP53_ENST00000445888.2_Missense_Mutation_p.K132N|TP53_ENST00000413465.2_Missense_Mutation_p.K132N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	132	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|KM -> NL (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(49)|p.0?(8)|p.Y126_K132delYSPALNK(6)|p.K39N(2)|p.N131fs*27(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.A129_K132delALNK(1)|p.Y126fs*11(1)|p.K132K(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.M133fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	32					1.64293e-13	1.80019e-13	1	1	0	A	7578534	C	A	7578534	3	1	37	1	0	0	0	0	1	0	0	0	16441	912	32	2	902	2	TP53	17	7578534	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1413	7578534	73616676	275	3590										
DNAH2	146754	broad.mit.edu	37	chr17	7660535	7660535	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctgcgtgaaaatctgctactCgttgctagagactacaatag	9	9	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:7660535C>T	ENST00000572933.1	+	13	3491	c.2031C>T	c.(2029-2031)ctC>ctT	p.L677L	DNAH2_ENST00000389173.2_Silent_p.L677L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	677	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATCTGCTACTCGTTGCTAGAG	0.493													27	227					0	0	1	0	0	T	7660535	C	T	7660535	2	4	37	1	0	0	0	0	0	0	0	1	4630	871	31	1		1	DNAH2	17	7660535	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	82001	7660535	73534675	276	3591										
KDM6B	23135	broad.mit.edu	37	chr17	7748879	7748879	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccaactcaggctggatgcatCgggcagtggaccctccaggg	14	13	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:7748879C>T	ENST00000254846.5	+	4	396	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W	KDM6B_ENST00000448097.2_Missense_Mutation_p.R3W	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	3					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CTGGATGCATCGGGCAGTGGA	0.637													10	108					0	0	1	0	0	T	7748879	C	T	7748879	3	4	37	1	0	0	0	0	1	0	0	0	8180	875	31	1	9	1	KDM6B	17	7748879	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	88344	7748879	73446331	277	3592										
MYH4	4622	broad.mit.edu	37	chr17	10363565	10363565	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acgaactcattgccgaccttGactctgggatagcagagaga	11	10	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:10363565G>C	ENST00000255381.2	-	13	1331	c.1221C>G	c.(1219-1221)gtC>gtG	p.V407V	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	407	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.V407V(1)		NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGCCGACCTTGACTCTGGGAT	0.453													5	80					0	0	1	0	0	C	10363565	G	C	10363565	2	2	37	1	0	0	0	0	0	0	0	1	10084	1277	45	2		2	MYH4	17	10363565	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2614686	10363565	70831645	278	3593										
UNC119	9094	broad.mit.edu	37	chr17	26874818	26874818	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gttgcggaagtagtgcctctCgatcatgcggaagttgttga	14	7	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:26874818C>T	ENST00000484980.1	-	3	3363	c.202G>A	c.(202-204)Gag>Aag	p.E68K	UNC119_ENST00000335765.4_Missense_Mutation_p.E163K|UNC119_ENST00000470125.1_Missense_Mutation_p.E68K|UNC119_ENST00000301032.4_Missense_Mutation_p.E163K			Q13432	U119A_HUMAN	unc-119 homolog (C. elegans)	163					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction				breast(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	7	Lung NSC(42;0.00431)					TAGTGCCTCTCGATCATGCGG	0.517											OREG0024277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	119					0	0	1	0	0	T	26874818	C	T	26874818	3	4	37	1	0	0	0	0	1	0	0	0	17041	893	31	1	296	1	UNC119	17	26874818	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	16511253	26874818	54320392	279	3594										
SGK494	0	broad.mit.edu	37	chr17	26939325	26939325	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aaagagacggatggaagcctCaggaaagcagccaacagccg	13	10	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:26939325C>G	ENST00000301037.5	-	6	606	c.607G>C	c.(607-609)Gag>Cag	p.E203Q	SPAG5-AS1_ENST00000424210.1_RNA|RP11-192H23.4_ENST00000534850.1_Intron|RP11-192H23.4_ENST00000577790.1_Intron|SPAG5-AS1_ENST00000554154.1_RNA	NM_001174103.1	NP_001167574.1																					ATGGAAGCCTCAGGAAAGCAG	0.498													7	62					0	0	1	0	0	G	26939325	C	G	26939325	3	3	37	1	0	0	0	0	1	0	0	0	14266	835	29	2	653	2	SGK494	17	26939325	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	64507	26939325	54255885	280	3595										
PEX12	5193	broad.mit.edu	37	chr17	33904942	33904942	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acatgctgaagagcgggtctCactgctgtcattaaactgtc	10	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:33904942C>T	ENST00000225873.4	-	1	706	c.99G>A	c.(97-99)gtG>gtA	p.V33V		NM_000286.2	NP_000277.1	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	33					protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(8)	18				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GAGCGGGTCTCACTGCTGTCA	0.463													11	83					0	0	1	0	0	T	33904942	C	T	33904942	2	4	37	1	0	0	0	0	0	0	0	1	11787	813	29	3		3	PEX12	17	33904942	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6965617	33904942	47290268	281	3596										
ACACA	31	broad.mit.edu	37	chr17	35640260	35640260	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cataagaccacctacggataGaccgcatgcatttcactgct	7	13	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:35640260G>C	ENST00000353139.5	-	5	999	c.518C>G	c.(517-519)tCt>tGt	p.S173C	ACACA_ENST00000394406.2_Missense_Mutation_p.S136C|ACACA_ENST00000360679.3_Missense_Mutation_p.S78C|ACACA_ENST00000335166.5_Missense_Mutation_p.S58C	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	136	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CCTACGGATAGACCGCATGCA	0.438													7	57					0	0	1	0	0	C	35640260	G	C	35640260	3	2	37	1	0	0	0	0	1	0	0	0	106	942	33	2	6841	2	ACACA	17	35640260	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1735318	35640260	45554950	282	3597										
EIF1	10209	broad.mit.edu	37	chr17	39846029	39846029	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gagcttaaccttttttttcaGacccctttgctgatgcaagt	7	10	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:39846029G>C	ENST00000469257.1	+	2	177		c.e2-1		JUP_ENST00000540235.1_Intron|EIF1_ENST00000591776.1_Splice_Site|EIF1_ENST00000310837.4_Intron			P41567	EIF1_HUMAN	eukaryotic translation initiation factor 1						regulation of translational initiation|response to stress	cytoplasm	translation initiation factor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(2)|skin(1)	5		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TTTTTTTTCAGACCCCTTTGC	0.483											OREG0024409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	55					0	0	1	0	0	C	39846029	G	C	39846029	5	2	37	1	0	0	0	0	0	0	1	0	5016	956	33	2	37	2	EIF1	17	39846029	Splice_Site	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4205769	39846029	41349181	283	3598										
NAGLU	4669	broad.mit.edu	37	chr17	40695097	40695097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctggctcttccagcaccagcCgcagttctgggggcccgccc	12	18	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:40695097C>T	ENST00000225927.2	+	6	1174	c.1073C>T	c.(1072-1074)cCg>cTg	p.P358L	RP11-400F19.8_ENST00000585572.1_RNA	NM_000263.3	NP_000254.2	P54802	ANAG_HUMAN	N-acetylglucosaminidase, alpha	358			P -> L (in MPS3B).			lysosome	alpha-N-acetylglucosaminidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	12		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CAGCACCAGCCGCAGTTCTGG	0.617													19	165					0	0	1	0	0	T	40695097	C	T	40695097	3	4	37	1	0	0	0	0	1	0	0	0	10190	652	23	1	1095	1	NAGLU	17	40695097	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	849068	40695097	40500113	284	3599										
TMUB2	79089	broad.mit.edu	37	chr17	42266526	42266526	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tagcttggctctctacctacGtagcagacagcggtagcaac	10	12	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:42266526G>A	ENST00000319511.6	+	2	762	c.112G>A	c.(112-114)Gta>Ata	p.V38I	TMUB2_ENST00000587989.1_Missense_Mutation_p.V58I|TMUB2_ENST00000357984.3_Missense_Mutation_p.V38I|TMUB2_ENST00000592825.1_Missense_Mutation_p.V38I|TMUB2_ENST00000446571.3_Missense_Mutation_p.V38I|TMUB2_ENST00000590235.1_Missense_Mutation_p.V38I|TMUB2_ENST00000589785.1_Missense_Mutation_p.V38I|TMUB2_ENST00000589856.1_Missense_Mutation_p.V38I|TMUB2_ENST00000538716.2_Missense_Mutation_p.V58I|TMUB2_ENST00000589184.1_Intron|TMUB2_ENST00000587172.1_Missense_Mutation_p.V38I	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	58						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CTCTACCTACGTAGCAGACAG	0.587													16	133					0	0	1	0	0	A	42266526	G	A	42266526	3	1	37	1	0	0	0	0	1	0	0	0	16324	1145	40	1	178	1	TMUB2	17	42266526	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1571429	42266526	38928684	285	3600										
GRN	2896	broad.mit.edu	37	chr17	42429011	42429011	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aacaggggccccaccaggtgCcctggatggagaaggcccca	14	14	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:42429011C>T	ENST00000053867.3	+	10	1089	c.1027C>T	c.(1027-1029)Ccc>Tcc	p.P343S	GRN_ENST00000589265.1_Missense_Mutation_p.P186S|GRN_ENST00000589923.1_3'UTR	NM_002087.2	NP_002078.1	P28799	GRN_HUMAN	granulin	343					signal transduction	extracellular space	cytokine activity|growth factor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCACCAGGTGCCCTGGATGGA	0.607													34	67					0	0	1	0	0	T	42429011	C	T	42429011	3	4	37	1	0	0	0	0	1	0	0	0	6844	739	26	3	1061	3	GRN	17	42429011	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	162485	42429011	38766199	286	3601										
CDK5RAP3	80279	broad.mit.edu	37	chr17	46053347	46053347	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggtggaacgaccccacctcGaggagcttcctgagcaggtg	14	12	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:46053347G>A	ENST00000536708.2	+	8	950	c.841G>A	c.(841-843)Gag>Aag	p.E281K	CDK5RAP3_ENST00000338399.4_Missense_Mutation_p.E256K	NM_001278197.1	NP_001265126.1	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	256					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding			NS(1)|central_nervous_system(2)|cervix(3)|endometrium(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	18						ACCCCACCTCGAGGAGCTTCC	0.607													10	70					0	0	1	0	0	A	46053347	G	A	46053347	3	1	37	1	0	0	0	0	1	0	0	0	3169	1059	37	1	796	1	CDK5RAP3	17	46053347	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	3624336	46053347	35141863	287	3602										
RNF43	54894	broad.mit.edu	37	chr17	56492817	56492817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	taatagctttctgttctgctGatctttcagactccaccgct	6	12	4	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:56492817G>A	ENST00000584437.1	-	1	2077	c.122C>T	c.(121-123)tCa>tTa	p.S41L	BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000583753.1_Missense_Mutation_p.S41L|RNF43_ENST00000581868.1_Intron|RNF43_ENST00000577716.1_Missense_Mutation_p.S41L|RNF43_ENST00000500597.2_Missense_Mutation_p.S41L|RNF43_ENST00000407977.2_Missense_Mutation_p.S41L			Q68DV7	RNF43_HUMAN	ring finger protein 43	41						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding	p.S41*(1)		NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGTTCTGCTGATCTTTCAGA	0.537													6	75					0	0	1	0	0	A	56492817	G	A	56492817	3	1	37	1	0	0	0	0	1	0	0	0	13546	1294	45	3	2265	3	RNF43	17	56492817	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	10439470	56492817	24702393	288	3603										
TEX2	55852	broad.mit.edu	37	chr17	62291464	62291464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcctcctcgccggatgccgaGaagtgaatggcgatggtatc	13	11	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:62291464G>A	ENST00000258991.3	-	2	198	c.114C>T	c.(112-114)ttC>ttT	p.F38F	TEX2_ENST00000583097.1_Silent_p.F38F|TEX2_ENST00000584379.1_Silent_p.F38F			Q8IWB9	TEX2_HUMAN	testis expressed 2	38					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CGGATGCCGAGAAGTGAATGG	0.562													10	84					0	0	1	0	0	A	62291464	G	A	62291464	2	1	37	1	0	0	0	0	0	0	0	1	15839	933	33	3		3	TEX2	17	62291464	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	5798647	62291464	18903746	289	3604										
PRKAR1A	5573	broad.mit.edu	37	chr17	66526119	66526119	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agagtttgttgaagtgggaaGattggggccttctgattatt	14	3	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:66526119G>T	ENST00000589228.1	+	10	1078	c.950G>T	c.(949-951)aGa>aTa	p.R317I	PRKAR1A_ENST00000586397.1_Missense_Mutation_p.R317I|PRKAR1A_ENST00000536854.2_Missense_Mutation_p.R317I|PRKAR1A_ENST00000392711.1_Missense_Mutation_p.R317I|PRKAR1A_ENST00000358598.2_Missense_Mutation_p.R317I|PRKAR1A_ENST00000588188.2_Missense_Mutation_p.R317I	NM_001276289.1|NM_001278433.1	NP_001263218.1|NP_001265362.1	P10644	KAP0_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, alpha	317					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|soft_tissue(2)|stomach(2)|testis(1)|thyroid(2)|upper_aerodigestive_tract(1)	31	Breast(10;1.64e-13)					GAAGTGGGAAGATTGGGGCCT	0.383			"T, Mis, N, F, S"	RET	papillary thyroid	"myxoma, endocrine, papillary thyroid"			Primary Pigmented Nodular Adrenocortical Disease, Familial;Carney Complex;Cardiac Myxomas, Familial Clustering of				11	88					2.27111e-07	2.4214e-07	1	1	0	T	66526119	G	T	66526119	3	4	37	1	0	0	0	0	1	0	0	0	12554	942	33	2	984	2	PRKAR1A	17	66526119	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4234655	66526119	14669091	290	3605										
MRPS7	51081	broad.mit.edu	37	chr17	73259478	73259478	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	accatgccgcttctgcagagGaacaggcaaccatcgaacgc	10	14	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:73259478G>A	ENST00000579761.1	+	4	624	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	MRPS7_ENST00000579002.1_Missense_Mutation_p.E162K|MRPS7_ENST00000245539.6_Missense_Mutation_p.E133K			Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7	133					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)	6	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TTCTGCAGAGGAACAGGCAAC	0.522													48	425					0	0	1	0	0	A	73259478	G	A	73259478	3	1	37	1	0	0	0	0	1	0	0	0	9896	1175	41	3	411	3	MRPS7	17	73259478	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6733359	73259478	7935732	291	3606										
TSPAN10	83882	broad.mit.edu	37	chr17	79615062	79615062	+	RNA	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctgcgcctggatgcggacgCagctcagagagtggtgtacc	15	12	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr17:79615062C>A	ENST00000328585.4	+	0	896				TSPAN10_ENST00000572675.1_RNA	NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GATGCGGACGCAGCTCAGAGA	0.711													4	16					0.150653	0.151001	1	1	0	A	79615062	C	A	79615062	1	1	37	0	1	0	0	0	0	0	0	0	16694	710	25	5		5	TSPAN10	17	79615062	RNA	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6355584	79615062	1580148	292	3607										
PTPRM	5797	broad.mit.edu	37	chr18	8406128	8406128	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atcagtacaagttctgctacGaggtggccctggaatacttg	11	9	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr18:8406128G>A	ENST00000332175.8	+	31	5364	c.4327G>A	c.(4327-4329)Gag>Aag	p.E1443K	PTPRM_ENST00000400053.4_Missense_Mutation_p.E1381K|PTPRM_ENST00000400060.4_Missense_Mutation_p.E1457K|PTPRM_ENST00000580170.1_Missense_Mutation_p.E1456K|PTPRM_ENST00000444013.1_Missense_Mutation_p.E1230K	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1443	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GTTCTGCTACGAGGTGGCCCT	0.453													5	42					0	0	1	0	0	A	8406128	G	A	8406128	3	1	37	1	0	0	0	0	1	0	0	0	12857	1059	37	1	4496	1	PTPRM	18	8406128	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		8406128	69671120	293	3608										
KCTD1	284252	broad.mit.edu	37	chr18	24081165	24081165	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgccttggttgttcagtggaGatgcaggggatctagtgatc	15	6	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr18:24081165G>C	ENST00000417602.1	-	2	1858	c.1859C>G	c.(1858-1860)tCt>tGt	p.S620C	KCTD1_ENST00000317932.7_Missense_Mutation_p.S12C|KCTD1_ENST00000579973.1_Missense_Mutation_p.S12C|KCTD1_ENST00000408011.3_Missense_Mutation_p.S12C|KCTD1_ENST00000580059.1_Missense_Mutation_p.S12C	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	12					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			GTTCAGTGGAGATGCAGGGGA	0.478													6	114					0	0	1	0	0	C	24081165	G	C	24081165	3	2	37	1	0	0	0	0	1	0	0	0	8139	942	33	2	754	2	KCTD1	18	24081165	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	15675037	24081165	53996083	294	3609										
DCC	1630	broad.mit.edu	37	chr18	50936947	50936947	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttgatactatgtattactttCgaattcaagcacgaaattca	5	7	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr18:50936947C>G	ENST00000442544.2	+	20	3677	c.3061C>G	c.(3061-3063)Cga>Gga	p.R1021G	DCC_ENST00000581580.1_Missense_Mutation_p.R656G|DCC_ENST00000412726.1_Missense_Mutation_p.R849G	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1021	Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTATTACTTTCGAATTCAAGC	0.378													8	58					0	0	1	0	0	G	50936947	C	G	50936947	3	3	37	1	0	0	0	0	1	0	0	0	4305	876	31	2	3139	2	DCC	18	50936947	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	26855782	50936947	27140301	295	3610										
SERPINB7	8710	broad.mit.edu	37	chr18	61468144	61468144	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	atgcatcaggaacggaagttCaatttgtctgttattgagga	11	5	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr18:61468144C>T	ENST00000398019.2	+	7	967	c.642C>T	c.(640-642)ttC>ttT	p.F214F	SERPINB7_ENST00000546027.1_Silent_p.F214F|SERPINB7_ENST00000540675.1_Silent_p.F197F|SERPINB7_ENST00000336429.2_Silent_p.F214F	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	214					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				AACGGAAGTTCAATTTGTCTG	0.408													10	73					0	0	1	0	0	T	61468144	C	T	61468144	2	4	37	1	0	0	0	0	0	0	0	1	14159	825	29	3		3	SERPINB7	18	61468144	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10531197	61468144	16609104	296	3611										
C19orf26	255057	broad.mit.edu	37	chr19	1234625	1234625	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccgggtggggcgtggtggctGagctggcctcgcctgagtca	19	11	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:1234625G>C	ENST00000590083.1	-	6	864	c.572C>G	c.(571-573)tCa>tGa	p.S191*	C19orf26_ENST00000215376.6_Nonsense_Mutation_p.S185*|C19orf26_ENST00000382477.2_Nonsense_Mutation_p.S211*			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	211						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTGGTGGCTGAGCTGGCCTC	0.672										HNSCC(14;0.022)			8	11					0	0	1	0	0	C	1234625	G	C	1234625	4	2	37	1	0	0	0	0	0	1	0	0	1928	1294	45	2	805	2	C19orf26	19	1234625	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		1234625	57894358	297	3612										
APC2	10297	broad.mit.edu	37	chr19	1460850	1460850	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcctccgacagtgaggagctCcaccaggtacagggcggggt	16	12	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:1460850C>G	ENST00000535453.1	+	11	3228	c.1515C>G	c.(1513-1515)ctC>ctG	p.L505L	APC2_ENST00000238483.4_Silent_p.L231L|APC2_ENST00000233607.2_Silent_p.L505L|CTB-25B13.12_ENST00000588225.1_RNA			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	505					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGAGGAGCTCCACCAGGTAC	0.697													8	38					0	0	1	0	0	G	1460850	C	G	1460850	2	3	37	1	0	0	0	0	0	0	0	1	760	842	30	2		2	APC2	19	1460850	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	226225	1460850	57668133	298	3613										
ATP8B3	148229	broad.mit.edu	37	chr19	1796753	1796753	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgcaccatcaccgtgtggcaGatggccagcaggcgccagaa	13	14	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:1796753G>C	ENST00000539485.1	-	16	1943	c.1710C>G	c.(1708-1710)atC>atG	p.I570M	ATP8B3_ENST00000525591.1_Missense_Mutation_p.I523M|ATP8B3_ENST00000310127.6_Missense_Mutation_p.I570M			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	570					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTGGCAGATGGCCAGCA	0.716													7	32					0	0	1	0	0	C	1796753	G	C	1796753	3	2	37	1	0	0	0	0	1	0	0	0	1194	932	33	2	2278	2	ATP8B3	19	1796753	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	335903	1796753	57332230	299	3614										
PLEKHJ1	55111	broad.mit.edu	37	chr19	2233840	2233840	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgaccaccgtgccctgcgctCacgcctgcaagccactcagc	9	19	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:2233840C>T	ENST00000589097.1	-	7	1562	c.449G>A	c.(448-450)tGa>tAa	p.*150*	PLEKHJ1_ENST00000587962.1_3'UTR|PLEKHJ1_ENST00000591099.1_3'UTR|PLEKHJ1_ENST00000586608.1_Silent_p.*151*|PLEKHJ1_ENST00000326631.2_Silent_p.*150*|PLEKHJ1_ENST00000588545.1_Silent_p.*131*|PLEKHJ1_ENST00000587394.1_Intron|PLEKHJ1_ENST00000589791.1_5'UTR			Q9NW61	PKHJ1_HUMAN	pleckstrin homology domain containing, family J member 1	0							protein binding			endometrium(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCTGCGCTCACGCCTGCAA	0.637													4	20					0	0	1	0	0	T	2233840	C	T	2233840	2	4	37	1	0	0	0	0	0	0	0	1	12126	837	29	3		3	PLEKHJ1	19	2233840	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	437087	2233840	56895143	300	3615										
PIP5K1C	23396	broad.mit.edu	37	chr19	3656427	3656427	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tagtagccagggagcagcttCtgcaggaactcggcctcctt	12	12	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:3656427C>T	ENST00000335312.3	-	6	685	c.597G>A	c.(595-597)caG>caA	p.Q199Q	PIP5K1C_ENST00000589578.1_Silent_p.Q199Q|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000539785.1_Silent_p.Q199Q|PIP5K1C_ENST00000537021.1_Silent_p.Q199Q	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	199	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GGAGCAGCTTCTGCAGGAACT	0.642													11	58					0	0	1	0	0	T	3656427	C	T	3656427	2	4	37	1	0	0	0	0	0	0	0	1	11988	912	32	3		3	PIP5K1C	19	3656427	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1422587	3656427	55472556	301	3616										
FBN3	84467	broad.mit.edu	37	chr19	8176535	8176535	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cacccctctaatctcaccttCgcagaagaagccatccccgg	6	18	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:8176535C>T	ENST00000600128.1	-	32	4495	c.4081G>A	c.(4081-4083)Gaa>Aaa	p.E1361K	FBN3_ENST00000270509.2_Missense_Mutation_p.E1361K|FBN3_ENST00000601739.1_Missense_Mutation_p.E1361K			Q75N90	FBN3_HUMAN	fibrillin 3	1361	EGF-like 20; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ATCTCACCTTCGCAGAAGAAG	0.642													3	15					0	0	1	0	0	T	8176535	C	T	8176535	3	4	37	1	0	0	0	0	1	0	0	0	5736	893	31	1	4480	1	FBN3	19	8176535	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4520108	8176535	50952448	302	3617										
PKN1	5585	broad.mit.edu	37	chr19	14578566	14578566	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctctgaccctcgaagatttCaagttcctggcggtgctggg	12	12	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:14578566C>G	ENST00000242783.6	+	14	2010	c.1845C>G	c.(1843-1845)ttC>ttG	p.F615L	PKN1_ENST00000342216.4_Missense_Mutation_p.F621L	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	615	Protein kinase.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						TCGAAGATTTCAAGTTCCTGG	0.632													7	74					0	0	1	0	0	G	14578566	C	G	14578566	3	3	37	1	0	0	0	0	1	0	0	0	12026	825	29	2	1942	2	PKN1	19	14578566	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6402031	14578566	44550417	303	3618										
TECR	9524	broad.mit.edu	37	chr19	14675027	14675027	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgtcactcattccactacatCaagcgcctgctggagacgct	8	14	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:14675027C>G	ENST00000436007.2	+	8	586	c.462C>G	c.(460-462)atC>atG	p.I154M	TECR_ENST00000215567.5_Missense_Mutation_p.I139M|TECR_ENST00000600083.1_5'UTR|TECR_ENST00000596073.1_5'UTR			Q9NZ01	TECR_HUMAN	trans-2,3-enoyl-CoA reductase	139					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity			endometrium(1)|large_intestine(1)|ovary(1)	3						TCCACTACATCAAGCGCCTGC	0.627													15	94					0	0	1	0	0	G	14675027	C	G	14675027	3	3	37	1	0	0	0	0	1	0	0	0	15803	816	29	2	443	2	TECR	19	14675027	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	96461	14675027	44453956	304	3619										
ZNF493	284443	broad.mit.edu	37	chr19	21588648	21588648	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aagggacacagtacggtagtCaaacccccaggtaggtgaga	13	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:21588648C>G	ENST00000392288.2	+	3	352	c.243C>G	c.(241-243)gtC>gtG	p.V81V	CTD-2561J22.3_ENST00000600810.1_Silent_p.V62V|ZNF493_ENST00000596302.1_Silent_p.V82V|ZNF493_ENST00000594390.1_Silent_p.V81V|ZNF493_ENST00000355504.4_Intron|ZNF493_ENST00000339914.6_Silent_p.V82V	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						GTACGGTAGTCAAACCCCCAG	0.408													4	52					0	0	1	0	0	G	21588648	C	G	21588648	2	3	37	1	0	0	0	0	0	0	0	1	18000	813	29	2		2	ZNF493	19	21588648	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	6913621	21588648	37540335	305	3620										
UBA2	10054	broad.mit.edu	37	chr19	34960012	34960012	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcttcaaataatgccgacgtCagtgaagaagagagaagccg	11	8	3	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:34960012C>A	ENST00000439527.2	+	17	2019	c.1521C>A	c.(1519-1521)gtC>gtA	p.V507V	UBA2_ENST00000246548.4_Silent_p.V603V|UBA2_ENST00000588585.1_3'UTR|UBA2_ENST00000592791.1_Silent_p.V129V			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	603					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ATGCCGACGTCAGTGAAGAAG	0.393													4	35					1	1	1	1	0	A	34960012	C	A	34960012	2	1	37	1	0	0	0	0	0	0	0	1	16888	813	29	2		2	UBA2	19	34960012	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	13371364	34960012	24168971	306	3621										
ZFP82	284406	broad.mit.edu	37	chr19	36896496	36896496	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctcacctggatattgtcttCttcctttcctcacaactttc	3	15	4	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:36896496C>T	ENST00000392161.3	-	4	457	c.215G>A	c.(214-216)aGa>aAa	p.R72K	ZFP82_ENST00000392171.1_Intron	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	72	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATATTGTCTTCTTCCTTTCCT	0.438													7	38					0	0	1	0	0	T	36896496	C	T	36896496	3	4	37	1	0	0	0	0	1	0	0	0	17710	913	32	3	1391	3	ZFP82	19	36896496	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1936484	36896496	22232487	307	3622										
FCGBP	8857	broad.mit.edu	37	chr19	40395956	40395956	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aggccgggtgccgcaggtctGagccagcacatacacgcagg	15	13	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:40395956G>C	ENST00000221347.6	-	15	7448	c.7441C>G	c.(7441-7443)Cag>Gag	p.Q2481E		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2481	VWFD 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCGCAGGTCTGAGCCAGCACA	0.642													29	311					0	0	1	0	0	C	40395956	G	C	40395956	3	2	37	1	0	0	0	0	1	0	0	0	5810	1299	45	2	8864	2	FCGBP	19	40395956	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	3499460	40395956	18733027	308	3623										
PLD3	0	broad.mit.edu	37	chr19	40882619	40882619	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gacactcggagccatccatgCgggccttcctgctctctctg	10	16	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:40882619C>T	ENST00000409587.1	+	11	1520	c.1123C>T	c.(1123-1125)Cgg>Tgg	p.R375W	PLD3_ENST00000356508.5_Missense_Mutation_p.R375W|PLD3_ENST00000409419.1_Missense_Mutation_p.R375W|PLD3_ENST00000409735.4_Missense_Mutation_p.R375W|PLD3_ENST00000409281.1_Missense_Mutation_p.R375W			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	375					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			GCCATCCATGCGGGCCTTCCT	0.647													15	73					0	0	1	0	0	T	40882619	C	T	40882619	3	4	37	1	0	0	0	0	1	0	0	0	12094	759	27	1	1157	1	PLD3	19	40882619	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	486663	40882619	18246364	309	3624										
PSG8	0	broad.mit.edu	37	chr19	43268424	43268424	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgggtgggttccagaagtttAaaagtgatgctaggaggtgg	17	3	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:43268424A>G	ENST00000404209.4	-	2	170	c.74T>C	c.(73-75)tTa>tCa	p.L25S	PSG8_ENST00000406636.3_Intron|PSG8_ENST00000401467.2_Missense_Mutation_p.L25S|PSG8_ENST00000306511.4_Missense_Mutation_p.L25S	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	25						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				CCAGAAGTTTAAAAGTGATGC	0.478													11	145					0	0	1	0	0	G	43268424	A	G	43268424	3	3	37	1	0	0	0	0	1	0	0	0	12709	372	13	4	1243	4	PSG8	19	43268424	Missense_Mutation	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	2385805	43268424	15860559	310	3625										
ETHE1	23474	broad.mit.edu	37	chr19	44030378	44030378	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcccgaagcggatggagtctCcatcctcaatgtgtaagtca	11	11	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:44030378C>G	ENST00000600651.1	-	3	373	c.350G>C	c.(349-351)gGa>gCa	p.G117A	ETHE1_ENST00000292147.2_Missense_Mutation_p.G117A|ZNF575_ENST00000458714.2_5'UTR			O95571	ETHE1_HUMAN	ethylmalonic encephalopathy 1	117						mitochondrial matrix|nucleus	hydrolase activity|metal ion binding			central_nervous_system(1)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	5		Prostate(69;0.0153)				GATGGAGTCTCCATCCTCAAT	0.612													4	104					0	0	1	0	0	G	44030378	C	G	44030378	3	3	37	1	0	0	0	0	1	0	0	0	5300	855	30	2	434	2	ETHE1	19	44030378	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	761954	44030378	15098605	311	3626										
ZNF227	7770	broad.mit.edu	37	chr19	44740795	44740795	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcgagtccacctgggtgttCacaccagggaaaaactcttt	9	11	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:44740795C>T	ENST00000313040.7	+	6	2417	c.2212C>T	c.(2212-2214)Cac>Tac	p.H738Y	ZNF235_ENST00000589799.1_3'UTR|ZNF227_ENST00000391961.2_Missense_Mutation_p.H687Y|ZNF227_ENST00000589005.1_Missense_Mutation_p.H687Y	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	738					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				CCTGGGTGTTCACACCAGGGA	0.498													5	96					0	0	1	0	0	T	44740795	C	T	44740795	3	4	37	1	0	0	0	0	1	0	0	0	17838	826	29	3	2226	3	ZNF227	19	44740795	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	710417	44740795	14388188	312	3627										
ZNF296	162979	broad.mit.edu	37	chr19	45575710	45575710	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caggcccaggagcggggcctCcggggcctctgattctgtct	15	14	3	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:45575710C>T	ENST00000303809.2	-	3	791	c.577G>A	c.(577-579)Gag>Aag	p.E193K		NM_145288.1	NP_660331.1	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	193					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|lung(3)|prostate(1)|urinary_tract(2)	7						AGCGGGGCCTCCGGGGCCTCT	0.682													4	71					0	0	1	0	0	T	45575710	C	T	45575710	3	4	37	1	0	0	0	0	1	0	0	0	17884	864	30	3	854	3	ZNF296	19	45575710	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	834915	45575710	13553273	313	3628										
SYMPK	8189	broad.mit.edu	37	chr19	46332275	46332275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aggccagacaacaggcggatGaggcagtcctcatacttgtc	12	11	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:46332275G>A	ENST00000245934.7	-	14	2182	c.1938C>T	c.(1936-1938)ctC>ctT	p.L646L		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	646					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ACAGGCGGATGAGGCAGTCCT	0.652													13	86					0	0	1	0	0	A	46332275	G	A	46332275	2	1	37	1	0	0	0	0	0	0	0	1	15495	1277	45	3		3	SYMPK	19	46332275	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	756565	46332275	12796708	314	3629										
IL4I1	259307	broad.mit.edu	37	chr19	50393136	50393136	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gttgatcttgatggcggcgcGcagcgccgacttgaccgccg	15	13	1	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:50393136G>A	ENST00000595948.1	-	10	2181	c.1561C>T	c.(1561-1563)Cgc>Tgc	p.R521C	IL4I1_ENST00000341114.3_Missense_Mutation_p.R521C|IL4I1_ENST00000391826.2_Missense_Mutation_p.R499C	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	499						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		ATGGCGGCGCGCAGCGCCGAC	0.667													10	30					0	0	1	0	0	A	50393136	G	A	50393136	3	1	37	1	0	0	0	0	1	0	0	0	7740	1087	38	1	212	1	IL4I1	19	50393136	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4060861	50393136	8735847	315	3630										
ZNF649	65251	broad.mit.edu	37	chr19	52394225	52394225	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	attttctgatgtctaatgagTcctgacttctgtgaacaggg	10	7	3	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:52394225T>C	ENST00000354957.3	-	5	1448	c.1164A>G	c.(1162-1164)ggA>ggG	p.G388G	ZNF649_ENST00000600738.1_Silent_p.G360G|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		GTCTAATGAGTCCTGACTTCT	0.433													14	85					0	0	1	0	0	C	52394225	T	C	52394225	2	2	37	1	0	0	0	0	0	0	0	1	18120	1654	58	4		4	ZNF649	19	52394225	Silent	SNP	T	TCGA-N9-A4Q7-01A-11D-A28R-08	2001089	52394225	6734758	316	3631										
PPP2R1A	5518	broad.mit.edu	37	chr19	52714679	52714679	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctggttcacctcccgcacctCggcctgcggcctcttctccg	9	20	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:52714679C>T	ENST00000322088.6	+	4	495	c.437C>T	c.(436-438)tCg>tTg	p.S146L	PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S91L|PPP2R1A_ENST00000473455.2_3'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	146	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TCCCGCACCTCGGCCTGCGGC	0.652			Mis		clear cell ovarian carcinoma								11	90					0	0	1	0	0	T	52714679	C	T	52714679	3	4	37	1	0	0	0	0	1	0	0	0	12430	893	31	1	451	1	PPP2R1A	19	52714679	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	320454	52714679	6414304	317	3632										
ZNF610	162963	broad.mit.edu	37	chr19	52869526	52869526	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aatgtggcaaagcttttagaGagtgttcgggacttactacc	11	7	0	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr19:52869526G>C	ENST00000601151.1	+	5	1218	c.766G>C	c.(766-768)Gag>Cag	p.E256Q	ZNF610_ENST00000327920.8_Missense_Mutation_p.E299Q|ZNF610_ENST00000321287.8_Missense_Mutation_p.E299Q|ZNF610_ENST00000403906.3_Missense_Mutation_p.E299Q	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AGCTTTTAGAGAGTGTTCGGG	0.398													7	30					0	0	1	0	0	C	52869526	G	C	52869526	3	2	37	1	0	0	0	0	1	0	0	0	18092	943	33	2	909	2	ZNF610	19	52869526	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	154847	52869526	6259457	318	3633										
CPXM1	56265	broad.mit.edu	37	chr20	2777179	2777179	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccccatgccagtacccagctCatgctccccaggcttgtccg	8	19	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:2777179C>T	ENST00000380605.2	-	8	1103	c.1039G>A	c.(1039-1041)Gag>Aag	p.E347K		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	347					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GTACCCAGCTCATGCTCCCCA	0.612													32	137					0	0	1	0	0	T	2777179	C	T	2777179	3	4	37	1	0	0	0	0	1	0	0	0	3860	835	29	3	1193	3	CPXM1	20	2777179	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08		2777179	60248341	319	3634										
VPS16	64601	broad.mit.edu	37	chr20	2844651	2844651	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgagccattaaccagaagctGggggacacgcctggtgtctc	13	12	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:2844651G>T	ENST00000380445.3	+	16	1605	c.1533G>T	c.(1531-1533)ctG>ctT	p.L511L	VPS16_ENST00000481812.2_3'UTR|VPS16_ENST00000380469.3_Silent_p.L367L|VPS16_ENST00000380443.3_Silent_p.L197L	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	511					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						ACCAGAAGCTGGGGGACACGC	0.582													5	135					1.23904e-05	1.28943e-05	1	1	0	T	2844651	G	T	2844651	2	4	37	1	0	0	0	0	0	0	0	1	17252	1335	47	5		5	VPS16	20	2844651	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	67472	2844651	60180869	320	3635										
TASP1	55617	broad.mit.edu	37	chr20	13463939	13463939	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cctcagcttgtaaagcatgtGaacattctctagccagtatg	8	10	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:13463939G>C	ENST00000337743.4	-	11	1040	c.920C>G	c.(919-921)tCa>tGa	p.S307*	TASP1_ENST00000539805.1_Missense_Mutation_p.H110D|TASP1_ENST00000480436.1_5'UTR	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	307					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						TAAAGCATGTGAACATTCTCT	0.418													9	107					0	0	1	0	0	C	13463939	G	C	13463939	4	2	37	1	0	0	0	0	0	1	0	0	15645	1294	45	2	358	2	TASP1	20	13463939	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	10619288	13463939	49561581	321	3636										
SEC23B	10483	broad.mit.edu	37	chr20	18534978	18534978	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tggatgatgctcaagaaattCtgcaagcacgcttcccgatg	10	10	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:18534978C>G	ENST00000336714.3	+	18	2524	c.2092C>G	c.(2092-2094)Ctg>Gtg	p.L698V	SEC23B_ENST00000377475.3_Missense_Mutation_p.L698V|SEC23B_ENST00000377465.1_Missense_Mutation_p.L698V|SEC23B_ENST00000262544.2_Missense_Mutation_p.L698V	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	698					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						TCAAGAAATTCTGCAAGCACG	0.512													4	97					0	0	1	0	0	G	18534978	C	G	18534978	3	3	37	1	0	0	0	0	1	0	0	0	14045	912	32	2	2158	2	SEC23B	20	18534978	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5071039	18534978	44490542	322	3637										
RIN2	54453	broad.mit.edu	37	chr20	19956199	19956199	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttcagctccttcatgaccccGgagaagcggatggtccgcag	12	13	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:19956199G>A	ENST00000255006.6	+	8	1826	c.1677G>A	c.(1675-1677)ccG>ccA	p.P559P	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	510					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						TCATGACCCCGGAGAAGCGGA	0.572													16	136					0	0	1	0	0	A	19956199	G	A	19956199	2	1	37	1	0	0	0	0	0	0	0	1	13423	1103	39	1		1	RIN2	20	19956199	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1421221	19956199	43069321	323	3638										
EIF2S2	8894	broad.mit.edu	37	chr20	32677668	32677668	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agtcgtgtgtccttctgcagGattgtgtccggtgatcggca	14	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:32677668G>A	ENST00000374980.2	-	9	1091	c.870C>T	c.(868-870)atC>atT	p.I290I		NM_003908.3	NP_003899.2	P20042	IF2B_HUMAN	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	290						cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	11						CCTTCTGCAGGATTGTGTCCG	0.473													4	81					0	0	1	0	0	A	32677668	G	A	32677668	2	1	37	1	0	0	0	0	0	0	0	1	5036	1164	41	3		3	EIF2S2	20	32677668	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	12721469	32677668	30347852	324	3639										
RALGAPB	57148	broad.mit.edu	37	chr20	37146598	37146598	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatttgatgcagcatttgttCactgtaaacttcataatggg	8	6	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:37146598C>T	ENST00000262879.6	+	9	1656	c.1372C>T	c.(1372-1374)Cac>Tac	p.H458Y	RALGAPB_ENST00000397038.1_Missense_Mutation_p.H236Y|RALGAPB_ENST00000537204.1_Missense_Mutation_p.H458Y|RALGAPB_ENST00000397040.1_Missense_Mutation_p.H458Y|RALGAPB_ENST00000397042.3_Missense_Mutation_p.H458Y			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	458					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AGCATTTGTTCACTGTAAACT	0.388													9	70					0	0	1	0	0	T	37146598	C	T	37146598	3	4	37	1	0	0	0	0	1	0	0	0	13066	826	29	3	1402	3	RALGAPB	20	37146598	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	4468930	37146598	25878922	325	3640										
DBNDD2	55861	broad.mit.edu	37	chr20	44037201	44037201	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	acattttacagccagagacaGagtttgtctttcctctgtcc	7	11	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:44037201G>C	ENST00000372712.2	+	2	675	c.94G>C	c.(94-96)Gag>Cag	p.E32Q	DBNDD2_ENST00000372710.3_Missense_Mutation_p.E134Q|DBNDD2_ENST00000372717.1_Missense_Mutation_p.E32Q|SYS1-DBNDD2_ENST00000475242.1_3'UTR|DBNDD2_ENST00000360981.4_Missense_Mutation_p.E32Q|DBNDD2_ENST00000357275.2_Missense_Mutation_p.E32Q|DBNDD2_ENST00000372722.3_Missense_Mutation_p.E32Q|SYS1-DBNDD2_ENST00000452133.1_3'UTR|DBNDD2_ENST00000372723.3_Missense_Mutation_p.E32Q|DBNDD2_ENST00000372720.3_Missense_Mutation_p.E130Q			Q9BQY9	DBND2_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 2	130					negative regulation of protein kinase activity	cytoplasm	protein binding			breast(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				GCCAGAGACAGAGTTTGTCTT	0.567													9	87					0	0	1	0	0	C	44037201	G	C	44037201	3	2	37	1	0	0	0	0	1	0	0	0	4278	943	33	2	96	2	DBNDD2	20	44037201	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6890603	44037201	18988319	326	3641										
EYA2	2139	broad.mit.edu	37	chr20	45718018	45718018	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cggcaggggacaatgagattGaggtaatccaaaggggctct	15	7	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:45718018G>C	ENST00000327619.5	+	8	1176	c.802G>C	c.(802-804)Gag>Cag	p.E268Q	EYA2_ENST00000357410.3_Missense_Mutation_p.E268Q|EYA2_ENST00000317304.6_Missense_Mutation_p.E268Q	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	268					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				CAATGAGATTGAGGTAATCCA	0.587													4	63					0	0	1	0	0	C	45718018	G	C	45718018	3	2	37	1	0	0	0	0	1	0	0	0	5357	1291	45	2	828	2	EYA2	20	45718018	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1680817	45718018	17307502	327	3642										
SULF2	55959	broad.mit.edu	37	chr20	46293965	46293965	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gattttgtgacagtcacattCttctggccgctttttcttca	7	10	5	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr20:46293965C>T	ENST00000359930.4	-	14	2826	c.1975G>A	c.(1975-1977)Gaa>Aaa	p.E659K	SULF2_ENST00000467815.1_Missense_Mutation_p.E659K|SULF2_ENST00000484875.1_Missense_Mutation_p.E659K|SULF2_ENST00000361612.4_Missense_Mutation_p.E659K	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	659					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CAGTCACATTCTTCTGGCCGC	0.507													47	154					0	0	1	0	0	T	46293965	C	T	46293965	3	4	37	1	0	0	0	0	1	0	0	0	15426	922	32	3	669	3	SULF2	20	46293965	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	575947	46293965	16731555	328	3643										
BAGE2	85319	broad.mit.edu	37	chr21	11042864	11042867	+	RNA	DEL	AGTA	AGTA	-													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gttcatgagtcaatattaatAgtaagtaagcttaacatgtg					rs56773804		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:11042864_11042867delAGTA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		caatattaatagtaagtaagctta	0.358													4	5	---	---	---	---						-	11042867	AGTA	-	11042864	6	5	37	0	1	1	0	1	0	0	0	0	1290	435	15	0		0	BAGE2	21	11042864	RNA	DEL	AGTA	TCGA-N9-A4Q7-01A-11D-A28R-08		11042864	37087031	329	3644										
BAGE2	85319	broad.mit.edu	37	chr21	11062731	11062732	+	RNA	INS	-	-	AA													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ttatttcaaactttttttttINSaaatttattatctatttttt					rs71303621		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:11062731_11062732insAA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		actttttttttaaatttattat	0.46													2	4	---	---	---	---						AA	11062732	-	AA	11062731	6	5	37	0	1	1	1	0	0	0	0	0	1290	1769	61	0		0	BAGE2	21	11062731	RNA	INS	-	TCGA-N9-A4Q7-01A-11D-A28R-08	19867	11062731	37067164	330	3645										
BAGE2	85319	broad.mit.edu	37	chr21	11066883	11066884	+	RNA	INS	-	-	AA													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	actttggggttagaatccatINSaatactctcagtgtcaacca					rs147216020		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:11066883_11066884insAA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTAGAATCCATAATACTCTCAG	0.366													2	4	---	---	---	---						AA	11066884	-	AA	11066883	6	5	37	0	1	1	1	0	0	0	0	0	1290	1421	49	0		0	BAGE2	21	11066883	RNA	INS	-	TCGA-N9-A4Q7-01A-11D-A28R-08	4152	11066883	37063012	331	3646										
BAGE2	85319	broad.mit.edu	37	chr21	11093133	11093134	+	RNA	INS	-	-	A													0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tcatttatctgttctcccctINSaccccccacaacgctatcta					rs141935972		TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:11093133_11093134insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTTCTCCCCTACCCCCCACAA	0.401													2	4	---	---	---	---						A	11093134	-	A	11093133	6	5	37	0	1	1	1	0	0	0	0	0	1290	1537	53	0		0	BAGE2	21	11093133	RNA	INS	-	TCGA-N9-A4Q7-01A-11D-A28R-08	26250	11093133	37036762	332	3647										
BRWD1	54014	broad.mit.edu	37	chr21	40636563	40636563	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	taagacataattattagaatCtctaataagtggtcgatagt	7	4	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:40636563C>A	ENST00000342449.3	-	17	1786	c.1708G>T	c.(1708-1710)Gat>Tat	p.D570Y	BRWD1_ENST00000333229.2_Missense_Mutation_p.D570Y|BRWD1_ENST00000380800.3_Missense_Mutation_p.D570Y	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTATTAGAATCTCTAATAAGT	0.373													6	22					0.00198382	0.0020305	1	1	0	A	40636563	C	A	40636563	3	1	37	1	0	0	0	0	1	0	0	0	1527	913	32	2	5597	2	BRWD1	21	40636563	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	29543430	40636563	7493332	333	3648										
PRDM15	63977	broad.mit.edu	37	chr21	43298817	43298817	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccatcaccaggactcagcttCtctaaacgcggggttggggg	13	12	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:43298817C>G	ENST00000269844.3	-	3	510	c.400G>C	c.(400-402)Gaa>Caa	p.E134Q	PRDM15_ENST00000422911.1_Intron|PRDM15_ENST00000538201.1_Intron|PRDM15_ENST00000398548.1_Intron	NM_022115.3	NP_071398.3	P57071	PRD15_HUMAN	PR domain containing 15	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						GACTCAGCTTCTCTAAACGCG	0.642													3	13					0	0	1	0	0	G	43298817	C	G	43298817	3	3	37	1	0	0	0	0	1	0	0	0	12507	922	32	2	4239	2	PRDM15	21	43298817	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	2662254	43298817	4831078	334	3649										
PCNT	5116	broad.mit.edu	37	chr21	47831205	47831205	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aggagaaagcagaggaaattGaacaactccatgaagtcatt	10	6	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:47831205G>C	ENST00000359568.5	+	28	5325	c.5218G>C	c.(5218-5220)Gaa>Caa	p.E1740Q	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1740					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGAGGAAATTGAACAACTCCA	0.468													14	95					0	0	1	0	0	C	47831205	G	C	47831205	3	2	37	1	0	0	0	0	1	0	0	0	11636	1291	45	2	5328	2	PCNT	21	47831205	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4532388	47831205	298690	335	3650			1	6		3	3	451	G		1.384236e-05
PCNT	5116	broad.mit.edu	37	chr21	47831535	47831535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccctcagggaggctgaggtcGaagacatggcctcccggatc	14	13	1	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:47831535G>A	ENST00000359568.5	+	28	5655	c.5548G>A	c.(5548-5550)Gaa>Aaa	p.E1850K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1850					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GGCTGAGGTCGAAGACATGGC	0.617													7	60					0	0	1	0	0	A	47831535	G	A	47831535	3	1	37	1	0	0	0	0	1	0	0	0	11636	1059	37	1	5658	1	PCNT	21	47831535	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	330	47831535	298360	336	3651			1	6		3	3	451	G		1.384236e-05
PCNT	5116	broad.mit.edu	37	chr21	47831655	47831655	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggaaggcggcccactctgccGagctggaggccgtcctgttg	16	13	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr21:47831655G>A	ENST00000359568.5	+	28	5775	c.5668G>A	c.(5668-5670)Gag>Aag	p.E1890K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1890					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CCACTCTGCCGAGCTGGAGGC	0.672													9	35					0	0	1	0	0	A	47831655	G	A	47831655	3	1	37	1	0	0	0	0	1	0	0	0	11636	1059	37	1	5778	1	PCNT	21	47831655	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	120	47831655	298240	337	3652			1	6		3	3	451	G		1.384236e-05
POTEH	23784	broad.mit.edu	37	chr22	16279214	16279214	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccttccatatctatccagtgCatttaaatttgcttttttct	3	10	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:16279214C>T	ENST00000343518.6	-	4	1060	c.1009G>A	c.(1009-1011)Gca>Aca	p.A337T		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	337								p.A337S(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CTATCCAGTGCATTTAAATTT	0.313													11	233					0	0	1	0	0	T	16279214	C	T	16279214	3	4	37	1	0	0	0	0	1	0	0	0	12313	710	25	3	656	3	POTEH	22	16279214	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08		16279214	35025352	338	3653										
PI4KA	5297	broad.mit.edu	37	chr22	21081548	21081548	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gaccgcaggactttcaccccGtactgcgccgtgagagggtg	14	13	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:21081548G>A	ENST00000255882.6	-	41	4997	c.4911C>T	c.(4909-4911)taC>taT	p.Y1637Y	PI4KA_ENST00000572273.1_Silent_p.Y1579Y|PI4KA_ENST00000414196.3_Silent_p.Y389Y	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1579					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CTTTCACCCCGTACTGCGCCG	0.657													15	43					0	0	1	0	0	A	21081548	G	A	21081548	2	1	37	1	0	0	0	0	0	0	0	1	11920	1140	40	1		1	PI4KA	22	21081548	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	4802334	21081548	30223018	339	3654										
NEFH	4744	broad.mit.edu	37	chr22	29886561	29886561	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cagaggccaaagccaaggaaGatgacaagaccctctcaaaa	9	11	1	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:29886561G>T	ENST00000310624.6	+	4	2965	c.2932G>T	c.(2932-2934)Gat>Tat	p.D978Y		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	984	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						AGCCAAGGAAGATGACAAGAC	0.512													6	77					0.00116845	0.00120444	1	1	0	T	29886561	G	T	29886561	3	4	37	1	0	0	0	0	1	0	0	0	10360	942	33	2	2946	2	NEFH	22	29886561	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	8805013	29886561	21418005	340	3655										
ZMAT5	55954	broad.mit.edu	37	chr22	30134374	30134374	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cttctccagccagtcctccaGatggccctcggggagctcag	11	16	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:30134374G>C	ENST00000397781.3	-	6	578	c.328C>G	c.(328-330)Ctg>Gtg	p.L110V	ZMAT5_ENST00000344318.3_Missense_Mutation_p.L110V	NM_019103.2	NP_061976.1	Q9UDW3	ZMAT5_HUMAN	zinc finger, matrin-type 5	110					mRNA processing	cytoplasm|U12-type spliceosomal complex	nucleic acid binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(5;0.000597)|all cancers(5;0.0534)|Epithelial(10;0.0574)			CAGTCCTCCAGATGGCCCTCG	0.642													4	49					0	0	1	0	0	C	30134374	G	C	30134374	3	2	37	1	0	0	0	0	1	0	0	0	17752	933	33	2	192	2	ZMAT5	22	30134374	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	247813	30134374	21170192	341	3656										
SLC35E4	339665	broad.mit.edu	37	chr22	31042916	31042916	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agctacgtgggcatcgcactCactctttcaggaatgttcct	9	12	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:31042916C>T	ENST00000343605.4	+	2	1750	c.951C>T	c.(949-951)ctC>ctT	p.L317L	SLC35E4_ENST00000300385.8_Intron|SLC35E4_ENST00000406566.1_Intron	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	317	Leu-rich.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						GCATCGCACTCACTCTTTCAG	0.627													10	70					0	0	1	0	0	T	31042916	C	T	31042916	2	4	37	1	0	0	0	0	0	0	0	1	14641	813	29	3		3	SLC35E4	22	31042916	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	908542	31042916	20261650	342	3657										
MYH9	4627	broad.mit.edu	37	chr22	36697661	36697661	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	accttcaccagctcctcctcCttggccatcatctcctcctc	3	21	3	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:36697661C>A	ENST00000216181.5	-	21	2780	c.2550G>T	c.(2548-2550)aaG>aaT	p.K850N		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	850					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GCTCCTCCTCCTTGGCCATCA	0.617			T	ALK	ALCL		"Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"		Hereditary Macrothrombocytopenia, MYH9-associated		OREG0026520	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	47					0.00136819	0.00140701	1	1	0	A	36697661	C	A	36697661	3	1	37	1	0	0	0	0	1	0	0	0	10089	680	24	5	3416	5	MYH9	22	36697661	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	5654745	36697661	14606905	343	3658										
TCF20	6942	broad.mit.edu	37	chr22	42607449	42607449	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctttatcagcgccttcttttGatgagtgaaggaggcgacct	11	9	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:42607449G>C	ENST00000359486.3	-	1	3999	c.3863C>G	c.(3862-3864)tCa>tGa	p.S1288*	TCF20_ENST00000335626.4_Nonsense_Mutation_p.S1288*	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						GCCTTCTTTTGATGAGTGAAG	0.438													16	86					0	0	1	0	0	C	42607449	G	C	42607449	4	2	37	1	0	0	0	0	0	1	0	0	15749	1294	45	2	2057	2	TCF20	22	42607449	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	5909788	42607449	8697117	344	3659										
SERHL2	253190	broad.mit.edu	37	chr22	42968533	42968533	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cgatgaaatccaccctcaaaGaggtaagacggggctcaggc	12	11	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:42968533G>T	ENST00000327678.5	+	11	925	c.823G>T	c.(823-825)Gag>Tag	p.E275*	SERHL2_ENST00000340239.4_3'UTR|RRP7B_ENST00000357802.2_RNA|SERHL2_ENST00000335879.5_Nonsense_Mutation_p.E211*|SERHL2_ENST00000407614.4_Nonsense_Mutation_p.E95*	NM_014509.3	NP_055324.2	Q9H4I8	SEHL2_HUMAN	serine hydrolase-like 2	275						perinuclear region of cytoplasm|peroxisome	hydrolase activity			breast(1)|endometrium(2)|lung(3)|skin(1)|stomach(1)	8						CACCCTCAAAGAGGTAAGACG	0.527													5	73					0.014758	0.0149296	1	1	0	T	42968533	G	T	42968533	4	4	37	1	0	0	0	0	0	1	0	0	14131	943	33	2	865	2	SERHL2	22	42968533	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	361084	42968533	8336033	345	3660										
NUP50	10762	broad.mit.edu	37	chr22	45577223	45577223	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tagtagttaccgaagtaaaaGaagaagatgctttttactcc	8	6	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:45577223G>C	ENST00000347635.3	+	6	1526	c.1060G>C	c.(1060-1062)Gaa>Caa	p.E354Q	NUP50_ENST00000425733.2_Missense_Mutation_p.E104Q|NUP50_ENST00000407019.2_Missense_Mutation_p.E326Q|NUP50_ENST00000396096.2_Missense_Mutation_p.E326Q	NM_007172.3	NP_009103.2	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa	354	RanBD1.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CGAAGTAAAAGAAGAAGATGC	0.418													4	54					0	0	1	0	0	C	45577223	G	C	45577223	3	2	37	1	0	0	0	0	1	0	0	0	10813	943	33	2	1078	2	NUP50	22	45577223	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2608690	45577223	5727343	346	3661										
PKDREJ	10343	broad.mit.edu	37	chr22	46653081	46653081	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	aattatcctcataatgtgatCtacctgagaaactgcatgaa	6	8	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chr22:46653081C>G	ENST00000253255.5	-	1	6138	c.6139G>C	c.(6139-6141)Gat>Cat	p.D2047H		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	2047					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATAATGTGATCTACCTGAGAA	0.428													8	64					0	0	1	0	0	G	46653081	C	G	46653081	3	3	37	1	0	0	0	0	1	0	0	0	12017	913	32	2	626	2	PKDREJ	22	46653081	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1075858	46653081	4651485	347	3662										
FRMPD4	9758	broad.mit.edu	37	chrX	12735697	12735697	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctaactcttctgaaatgactGagagttctgaactggccaca	8	10	3	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:12735697G>A	ENST00000380682.1	+	16	3258	c.2752G>A	c.(2752-2754)Gag>Aag	p.E918K		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	918					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						TGAAATGACTGAGAGTTCTGA	0.493													24	199					0	0	1	0	0	A	12735697	G	A	12735697	3	1	37	1	0	0	0	0	1	0	0	0	6093	1291	45	3	2814	3	FRMPD4	23	12735697	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08		12735697	142534863	348	3663										
MAP3K15	389840	broad.mit.edu	37	chrX	19507020	19507020	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ggccatgtcaaagctttctcGgactccaagatggtagaaga	11	9	2	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:19507020G>A	ENST00000338883.4	-	2	426	c.427C>T	c.(427-429)Cga>Tga	p.R143*		NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	143							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					AAGCTTTCTCGGACTCCAAGA	0.488													24	84					0	0	1	0	0	A	19507020	G	A	19507020	4	1	37	1	0	0	0	0	0	1	0	0	9298	1124	39	1	3626	1	MAP3K15	23	19507020	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6771323	19507020	135763540	349	3664										
CNKSR2	22866	broad.mit.edu	37	chrX	21581355	21581355	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tatttatctctttttatataGaaaactctctacttcggtat	3	7	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:21581355G>C	ENST00000425654.2	+	12	1783		c.e12-1		CNKSR2_ENST00000279451.4_Splice_Site|CNKSR2_ENST00000379510.3_Splice_Site|CNKSR2_ENST00000485012.1_Splice_Site|CNKSR2_ENST00000543067.1_Splice_Site	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2						regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TTTTTATATAGAAAACTCTCT	0.323													4	29					0	0	1	0	0	C	21581355	G	C	21581355	5	2	37	1	0	0	0	0	0	0	1	0	3630	956	33	2	1443	2	CNKSR2	23	21581355	Splice_Site	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	2074335	21581355	133689205	350	3665										
KDM5C	8242	broad.mit.edu	37	chrX	53222263	53222263	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tccgccggttccaagccattCtggttctcctgggtgctggg	13	13	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:53222263C>G	ENST00000375401.3	-	26	5101	c.4569G>C	c.(4567-4569)caG>caC	p.Q1523H	KDM5C_ENST00000404049.3_Missense_Mutation_p.Q1522H|KDM5C_ENST00000375383.3_Missense_Mutation_p.Q1479H|KDM5C_ENST00000452825.3_Intron|KDM5C_ENST00000375379.3_Missense_Mutation_p.Q1520H	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1523					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CCAAGCCATTCTGGTTCTCCT	0.677			"N, F, S"		clear cell renal carcinoma								3	36					0	0	1	0	0	G	53222263	C	G	53222263	3	3	37	1	0	0	0	0	1	0	0	0	8177	912	32	2	215	2	KDM5C	23	53222263	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	31640908	53222263	102048297	351	3666										
TRO	7216	broad.mit.edu	37	chrX	54955689	54955689	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agtgccactttcagtggtggAgccagctctggctttggagg	15	9	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:54955689A>G	ENST00000173898.7	+	12	2644	c.2532A>G	c.(2530-2532)ggA>ggG	p.G844G	TRO_ENST00000319167.8_Intron|TRO_ENST00000375041.2_Silent_p.G447G|TRO_ENST00000399736.1_Intron|TRO_ENST00000420798.2_Silent_p.G375G|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	844	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						TCAGTGGTGGAGCCAGCTCTG	0.557													4	52					0	0	1	0	0	G	54955689	A	G	54955689	2	3	37	1	0	0	0	0	0	0	0	1	16634	291	11	4		4	TRO	23	54955689	Silent	SNP	A	TCGA-N9-A4Q7-01A-11D-A28R-08	1733426	54955689	100314871	352	3667										
HEPH	9843	broad.mit.edu	37	chrX	65483502	65483502	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccagaacacttaagccctctCaccgtcatcaccaaagagac	5	16	3	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:65483502C>T	ENST00000519389.1	+	20	3557	c.3378C>T	c.(3376-3378)ctC>ctT	p.L1126L	HEPH_ENST00000441993.2_Silent_p.L1075L|HEPH_ENST00000343002.2_Silent_p.L1072L|HEPH_ENST00000336279.5_Silent_p.L805L|HEPH_ENST00000419594.1_Silent_p.L883L|HEPH_ENST00000374727.3_Silent_p.L1075L			Q9BQS7	HEPH_HUMAN	hephaestin	1072					cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						TAAGCCCTCTCACCGTCATCA	0.443													6	62					0	0	1	0	0	T	65483502	C	T	65483502	2	4	37	1	0	0	0	0	0	0	0	1	7094	813	29	3		3	HEPH	23	65483502	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	10527813	65483502	89787058	353	3668										
P2RY10	0	broad.mit.edu	37	chrX	78216918	78216918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	caagtctctgctgccttttgGatccaattctttattacttt	5	10	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:78216918G>A	ENST00000171757.2	+	4	1181	c.901G>A	c.(901-903)Gat>Aat	p.D301N	P2RY10_ENST00000544091.1_Missense_Mutation_p.D301N	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	301						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.D301N(1)		breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						CTGCCTTTTGGATCCAATTCT	0.493													17	161					0	0	1	0	0	A	78216918	G	A	78216918	3	1	37	1	0	0	0	0	1	0	0	0	11393	1174	41	3	903	3	P2RY10	23	78216918	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	12733416	78216918	77053642	354	3669										
POF1B	79983	broad.mit.edu	37	chrX	84601021	84601021	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gggctgttggataatgtgatGatggcattgagcctgaggat	16	4	0	4			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:84601021G>A	ENST00000262753.4	-	6	713	c.568C>T	c.(568-570)Cat>Tat	p.H190Y	POF1B_ENST00000373145.3_Missense_Mutation_p.H190Y	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	190							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						ATAATGTGATGATGGCATTGA	0.438													5	47					0	0	1	0	0	A	84601021	G	A	84601021	3	1	37	1	0	0	0	0	1	0	0	0	12229	1290	45	3	1249	3	POF1B	23	84601021	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	6384103	84601021	70669539	355	3670										
RNF128	79589	broad.mit.edu	37	chrX	106034391	106034391	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gaagaggataatcgcagcgaGaccgcatcatctggatatgc	12	9	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:106034391G>A	ENST00000255499.2	+	6	1330	c.1080G>A	c.(1078-1080)gaG>gaA	p.E360E	RNF128_ENST00000324342.3_Silent_p.E334E	NM_194463.1	NP_919445.1	Q8TEB7	RN128_HUMAN	ring finger protein 128, E3 ubiquitin protein ligase	360						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						ATCGCAGCGAGACCGCATCAT	0.448													14	189					0	0	1	0	0	A	106034391	G	A	106034391	2	1	37	1	0	0	0	0	0	0	0	1	13487	933	33	3		3	RNF128	23	106034391	Silent	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	21433370	106034391	49236169	356	3671										
COL4A5	1287	broad.mit.edu	37	chrX	107834449	107834449	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ctcctggccctgctggccctCacattcctcctagtaagcta	7	17	1	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:107834449C>G	ENST00000328300.6	+	20	1571	c.1327C>G	c.(1327-1329)Cac>Gac	p.H443D	COL4A5_ENST00000361603.2_Missense_Mutation_p.H443D	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	443	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TGCTGGCCCTCACATTCCTCC	0.458									Alport syndrome with Diffuse Leiomyomatosis				5	78					0	0	1	0	0	G	107834449	C	G	107834449	3	3	37	1	0	0	0	0	1	0	0	0	3717	826	29	2	1405	2	COL4A5	23	107834449	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	1800058	107834449	47436111	357	3672										
PLS3	5358	broad.mit.edu	37	chrX	114856633	114856633	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	agctaatatgccattaccagGatataaagtgagagaaatta	8	5	0	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:114856633G>T	ENST00000420625.2	+	3	283	c.149G>T	c.(148-150)gGa>gTa	p.G50V	PLS3_ENST00000539310.1_Missense_Mutation_p.G5V|PLS3_ENST00000537301.1_Missense_Mutation_p.G28V|PLS3_ENST00000355899.3_Missense_Mutation_p.G50V|PLS3_ENST00000289290.3_Missense_Mutation_p.G5V	NM_001136025.3|NM_001172335.1	NP_001129497.1|NP_001165806.1	P13797	PLST_HUMAN	plastin 3	50						cytoplasm	actin binding|calcium ion binding			NS(2)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)	26						CCATTACCAGGATATAAAGTG	0.353													9	76					1.12685e-05	1.17832e-05	1	1	0	T	114856633	G	T	114856633	3	4	37	1	0	0	0	0	1	0	0	0	12155	1174	41	2	155	2	PLS3	23	114856633	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	7022184	114856633	40413927	358	3673										
F9	2158	broad.mit.edu	37	chrX	138630629	138630629	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gatatcgacttgcagaaaacCagaagtcctgtgaaccagca	9	10	0	3			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:138630629C>T	ENST00000218099.2	+	5	506	c.499C>T	c.(499-501)Cag>Tag	p.Q167*	F9_ENST00000394090.2_Nonsense_Mutation_p.Q129*	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	167	EGF-like 2.		Q -> H (in HEMB; mild).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGCAGAAAACCAGAAGTCCTG	0.348													5	55					0	0	1	0	0	T	138630629	C	T	138630629	4	4	37	1	0	0	0	0	0	1	0	0	5382	595	21	3	517	3	F9	23	138630629	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	23773996	138630629	16639931	359	3674										
MAGEA10	4109	broad.mit.edu	37	chrX	151303366	151303366	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	tgcttcccagatgacctcctCaggggtgcagtagccctcta	10	14	2	2			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:151303366C>T	ENST00000370323.4	-	4	1043	c.727G>A	c.(727-729)Gag>Aag	p.E243K	MAGEA10_ENST00000244096.3_Missense_Mutation_p.E243K|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	243	MAGE.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ATGACCTCCTCAGGGGTGCAG	0.512													12	95					0	0	1	0	0	T	151303366	C	T	151303366	3	4	37	1	0	0	0	0	1	0	0	0	9209	835	29	3	386	3	MAGEA10	23	151303366	Missense_Mutation	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	12672737	151303366	3967194	360	3675										
HCFC1	3054	broad.mit.edu	37	chrX	153217411	153217411	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	cggcaggggccagggcctcaGtggggaggtggtgatgctgc	21	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:153217411G>A	ENST00000310441.7	-	20	6107	c.5141C>T	c.(5140-5142)aCt>aTt	p.T1714I	HCFC1_ENST00000369984.4_Missense_Mutation_p.T1759I|HCFC1_ENST00000354233.3_Missense_Mutation_p.T1645I	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1714					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGGCCTCAGTGGGGAGGTG	0.652													6	16					0	0	1	0	0	A	153217411	G	A	153217411	3	1	37	1	0	0	0	0	1	0	0	0	7031	1029	36	3	994	3	HCFC1	23	153217411	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	1914045	153217411	2053149	361	3676										
FLNA	0	broad.mit.edu	37	chrX	153595790	153595790	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	ccgtaggcacgggctttcttCgggttcagtttgggccgcaa	14	11	2	0			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:153595790C>T	ENST00000422373.1	-	5	1091	c.843G>A	c.(841-843)ccG>ccA	p.P281P	FLNA_ENST00000344736.4_Silent_p.P281P|FLNA_ENST00000360319.4_Silent_p.P281P|FLNA_ENST00000369850.3_Silent_p.P281P	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	281					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding	p.P281P(1)		breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCTTTCTTCGGGTTCAGTT	0.622													11	88					0	0	1	0	0	T	153595790	C	T	153595790	2	4	37	1	0	0	0	0	0	0	0	1	5965	871	31	1		1	FLNA	23	153595790	Silent	SNP	C	TCGA-N9-A4Q7-01A-11D-A28R-08	378379	153595790	1674770	362	3677										
ATP6AP1	537	broad.mit.edu	37	chrX	153663762	153663762	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	gcatctactccttccactgcGagtatgtcagcagcctgagc	9	14	2	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:153663762G>A	ENST00000369762.2	+	9	1175	c.1114G>A	c.(1114-1116)Gag>Aag	p.E372K		NM_001183.4	NP_001174.2	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1	372					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(5)	14	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTCCACTGCGAGTATGTCAG	0.592													21	51					0	0	1	0	0	A	153663762	G	A	153663762	3	1	37	1	0	0	0	0	1	0	0	0	1163	1059	37	1	1148	1	ATP6AP1	23	153663762	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	67972	153663762	1606798	363	3678										
F8	2157	broad.mit.edu	37	chrX	154197759	154197759	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.506887052341598	184	7.89685534674094e-65	3.88994134161094	5.00878734622144	2.92027480428183	0.000419564795537087	0.00797173111520465	137	accttcgaggaatattgagtGcacttcaggagtggtgccca	12	9	1	1			TCGA-N9-A4Q7-01A-11D-A28R-08	TCGA-N9-A4Q7-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272fa0b4-6b90-4f05-bf1a-5b02bd90dfa7	43f5a1ae-b52c-4f69-9da1-c16cfa218bd1	g.chrX:154197759G>A	ENST00000360256.4	-	7	1056	c.856C>T	c.(856-858)Cac>Tac	p.H286Y		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	286	F5/8 type A 1.|Plastocyanin-like 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AATATTGAGTGCACTTCAGGA	0.453													29	97					0	0	1	0	0	A	154197759	G	A	154197759	3	1	37	1	0	0	0	0	1	0	0	0	5378	1319	46	3	6307	3	F8	23	154197759	Missense_Mutation	SNP	G	TCGA-N9-A4Q7-01A-11D-A28R-08	533997	154197759	1072801	364	3679										
CASZ1	54897	broad.mit.edu	37	chr1	10713827	10713827	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gttgggaggtttggtggcacTgggcccagcctcggtggcgg	20	9	0	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:10713827T>A	ENST00000377022.3	-	11	2604	c.2287A>T	c.(2287-2289)Agt>Tgt	p.S763C	CASZ1_ENST00000344008.5_Missense_Mutation_p.S763C|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	763					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TTGGTGGCACTGGGCCCAGCC	0.701													8	47					0	0	1	0	0	A	10713827	T	A	10713827	3	1	38	1	0	0	0	0	1	0	0	0	2703	1580	55	4	3040	4	CASZ1	1	10713827	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08		10713827	238536794	1	3680										
UBXN10	127733	broad.mit.edu	37	chr1	20517119	20517119	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cactgttgtcagcacagcagTtgacagcctcatttggcagc	10	12	2	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:20517119T>A	ENST00000375099.3	+	2	149	c.65T>A	c.(64-66)gTt>gAt	p.V22D		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	22										endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						AGCACAGCAGTTGACAGCCTC	0.512													9	116					0	0	1	0	0	A	20517119	T	A	20517119	3	1	38	1	0	0	0	0	1	0	0	0	16971	1725	60	4	67	4	UBXN10	1	20517119	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08	9803292	20517119	228733502	2	3681										
EIF3I	8668	broad.mit.edu	37	chr1	32694780	32694780	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gccatggatgtaaccacaacCtccaccaggattggcaagtt	9	12	0	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:32694780C>A	ENST00000373586.1	+	9	846	c.774C>A	c.(772-774)acC>acA	p.T258T		NM_003757.2	NP_003748.1	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3, subunit I	258						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				TAACCACAACCTCCACCAGGA	0.443													27	45					2.41591e-17	2.66139e-17	1	1	0	A	32694780	C	A	32694780	2	1	38	1	0	0	0	0	0	0	0	1	5047	668	24	5		5	EIF3I	1	32694780	Silent	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	12177661	32694780	216555841	3	3682										
FCRL5	83416	broad.mit.edu	37	chr1	157516848	157516848	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ggggtttctcttagtatttcTttcccaaggtaccgatggta	10	8	2	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:157516848T>A	ENST00000361835.3	-	3	349	c.192A>T	c.(190-192)aaA>aaT	p.K64N	FCRL5_ENST00000356953.4_Missense_Mutation_p.K64N|FCRL5_ENST00000368191.3_Intron|FCRL5_ENST00000368188.2_Missense_Mutation_p.K64N|FCRL5_ENST00000368190.3_Missense_Mutation_p.K64N|FCRL5_ENST00000368189.3_Missense_Mutation_p.K64N	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	64	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TTAGTATTTCTTTCCCAAGGT	0.502													23	89					0	0	1	0	0	A	157516848	T	A	157516848	3	1	38	1	0	0	0	0	1	0	0	0	5830	1606	56	4	2801	4	FCRL5	1	157516848	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08	124822068	157516848	91733773	4	3683										
FMN2	56776	broad.mit.edu	37	chr1	240371964	240371964	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	caggacaaagggagtaggaaGcagcccatagagccttgtcg	14	9	0	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:240371964G>C	ENST00000319653.9	+	5	4082	c.3852G>C	c.(3850-3852)aaG>aaC	p.K1284N		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1284	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGAGTAGGAAGCAGCCCATAG	0.468													9	60					0	0	1	0	0	C	240371964	G	C	240371964	3	2	38	1	0	0	0	0	1	0	0	0	5982	962	34	5	3870	5	FMN2	1	240371964	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	82855116	240371964	8878657	5	3684										
KIF26B	55083	broad.mit.edu	37	chr1	245851417	245851417	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ccgcgcggggaggagcctggGccgcagcgccgggacctcgc	19	16	0	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr1:245851417G>A	ENST00000366518.4	+	9	4093	c.3989G>A	c.(3988-3990)gGc>gAc	p.G1330D	KIF26B_ENST00000407071.2_Missense_Mutation_p.G1711D			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1711					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGGAGCCTGGGCCGCAGCGCC	0.746													8	6					0	0	1	0	0	A	245851417	G	A	245851417	3	1	38	1	0	0	0	0	1	0	0	0	8336	1203	42	3	5178	3	KIF26B	1	245851417	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	5479453	245851417	3399204	6	3685										
SULT1C3	442038	broad.mit.edu	37	chr2	108868909	108868909	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gcccagactctagatagacaCgctttccttgaactgaaatt	7	11	1	5			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr2:108868909C>T	ENST00000329106.2	+	2	261	c.261C>T	c.(259-261)caC>caT	p.H87H	SULT1C3_ENST00000376700.1_Silent_p.H87H	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	87						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						TAGATAGACACGCTTTCCTTG	0.373													12	25					0	0	1	0	0	T	108868909	C	T	108868909	2	4	38	1	0	0	0	0	0	0	0	1	15433	535	19	1		1	SULT1C3	2	108868909	Silent	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08		108868909	134330464	7	3686										
BCL2L11	10018	broad.mit.edu	37	chr2	111921771	111921772	+	Frame_Shift_Ins	INS	-	-	A													0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	atggttatcttacgactgttINSacgttacattgtccgcctgg							TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr2:111921771_111921772insA	ENST00000393256.3	+	4	833_834	c.560_561insA	c.(559-561)tcgfs	p.S187fs	BCL2L11_ENST00000308659.8_Frame_Shift_Ins_p.S127fs	NM_001204106.1|NM_006538.4|NM_138621.4|NM_138627.3	NP_001191035.1|NP_006529.1|NP_619527.1|NP_619533.1	O43521	B2L11_HUMAN	BCL2-like 11 (apoptosis facilitator)	187					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(3)|lung(2)|prostate(2)	11						TTACGACTGTTACGTTACATTG	0.436													37	75	---	---	---	---						A	111921772	-	A	111921771	7	5	38	1	0	1	1	0	0	0	0	0	1367	1764	61	0	699	0	BCL2L11	2	111921771	Frame_Shift_Ins	INS	-	TCGA-N9-A4Q8-01A-31D-A28R-08	3052862	111921771	131277602	8	3687										
COL4A4	1286	broad.mit.edu	37	chr2	227896894	227896894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tgggggacctttctttccacGaggacctggaggagagattc	14	9	1	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr2:227896894G>A	ENST00000396625.3	-	39	3883	c.3676C>T	c.(3676-3678)Cgt>Tgt	p.R1226C	COL4A4_ENST00000329662.7_Missense_Mutation_p.R1226C	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1226	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTCTTTCCACGAGGACCTGGA	0.527													38	31					0	0	1	0	0	A	227896894	G	A	227896894	3	1	38	1	0	0	0	0	1	0	0	0	3716	1058	37	1	1436	1	COL4A4	2	227896894	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	115975123	227896894	15302479	9	3688										
SLC4A7	9497	broad.mit.edu	37	chr3	27475588	27475588	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gaagctatcatgttgtctaaTaccatatctattcaatgaaa	5	7	4	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr3:27475588T>A	ENST00000295736.5	-	6	640	c.570A>T	c.(568-570)gtA>gtT	p.V190V	SLC4A7_ENST00000440156.1_Silent_p.V199V|SLC4A7_ENST00000455077.1_Silent_p.V195V|SLC4A7_ENST00000435667.2_Silent_p.V199V|SLC4A7_ENST00000388777.4_5'UTR|SLC4A7_ENST00000428386.1_Silent_p.V190V|SLC4A7_ENST00000437179.1_Silent_p.V195V|SLC4A7_ENST00000445684.1_Silent_p.V199V|SLC4A7_ENST00000446700.1_Silent_p.V195V|SLC4A7_ENST00000454389.1_Silent_p.V199V|SLC4A7_ENST00000425128.2_Silent_p.V195V	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	190						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TGTTGTCTAATACCATATCTA	0.323													4	29					0	0	1	0	0	A	27475588	T	A	27475588	2	1	38	1	0	0	0	0	0	0	0	1	14712	1393	49	4		4	SLC4A7	3	27475588	Silent	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08		27475588	170546842	10	3689										
HHIP	64399	broad.mit.edu	37	chr4	145580927	145580927	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tatgtgaagatacttaccccTgaaggagaaattttcaagga	9	6	1	4			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr4:145580927T>C	ENST00000296575.3	+	4	1423	c.768T>C	c.(766-768)ccT>ccC	p.P256P	HHIP_ENST00000434550.2_Silent_p.P256P|HHIP_ENST00000511314.1_3'UTR|HHIP-AS1_ENST00000512359.1_RNA	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	256						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TACTTACCCCTGAAGGAGAAA	0.428													58	72					0	0	1	0	0	C	145580927	T	C	145580927	2	2	38	1	0	0	0	0	0	0	0	1	7132	1567	55	4		4	HHIP	4	145580927	Silent	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08		145580927	45573349	11	3690										
PRPF4B	8899	broad.mit.edu	37	chr6	4021681	4021681	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tggccgccgcggagacccagTcgctacgggagcagccagag	16	14	0	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:4021681T>G	ENST00000337659.6	+	1	122	c.22T>G	c.(22-24)Tcg>Gcg	p.S8A		NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	8						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GGAGACCCAGTCGCTACGGGA	0.662													11	10					0	0	1	0	0	G	4021681	T	G	4021681	3	3	38	1	0	0	0	0	1	0	0	0	12624	1667	58	4	24	4	PRPF4B	6	4021681	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08		4021681	167093386	12	3691										
GFOD1	54438	broad.mit.edu	37	chr6	13365867	13365867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cgtccagcggcgtggccgtgCggtcgcagatgacgttcttg	16	12	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:13365867C>T	ENST00000379287.3	-	2	945	c.281G>A	c.(280-282)cGc>cAc	p.R94H	GFOD1_ENST00000379284.1_5'UTR	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	94						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			CGTGGCCGTGCGGTCGCAGAT	0.657													32	74					0	0	1	0	0	T	13365867	C	T	13365867	3	4	38	1	0	0	0	0	1	0	0	0	6384	768	27	1	895	1	GFOD1	6	13365867	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	9344186	13365867	157749200	13	3692										
HLA-DRA	3122	broad.mit.edu	37	chr6	32410986	32410986	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tccagaggtaactgtgctcaCaaacagccctgtggaactga	10	11	1	2	rs61117681		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:32410986C>T	ENST00000395388.2	+	3	462	c.353C>T	c.(352-354)aCa>aTa	p.T118I	HLA-DRA_ENST00000374982.5_Intron	NM_019111.4	NP_061984.2	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR alpha	118	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						ACTGTGCTCACAAACAGCCCT	0.512									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of				7	57					0	0	1	0	0	T	32410986	C	T	32410986	3	4	38	1	0	0	0	0	1	0	0	0	7247	478	17	3	363	3	HLA-DRA	6	32410986	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	19045119	32410986	138704081	14	3693										
HTR1E	3354	broad.mit.edu	37	chr6	87725129	87725129	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cactgagaagatgctcatttGcatgactctggtggtcatca	10	9	4	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:87725129G>T	ENST00000305344.4	+	2	780	c.77G>T	c.(76-78)tGc>tTc	p.C26F	HTR1E_ENST00000369584.1_Missense_Mutation_p.C26F	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	26					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATGCTCATTTGCATGACTCTG	0.498													49	41					2.43139e-17	2.66139e-17	1	1	0	T	87725129	G	T	87725129	3	4	38	1	0	0	0	0	1	0	0	0	7482	1319	46	5	79	5	HTR1E	6	87725129	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	55314143	87725129	83389938	15	3694										
BCLAF1	9774	broad.mit.edu	37	chr6	136589310	136589310	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tttcacttacaaaggttcctCgtggtcggctaactcctgca	8	12	1	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:136589310C>G	ENST00000531224.1	-	10	2639	c.2387G>C	c.(2386-2388)cGa>cCa	p.R796P	BCLAF1_ENST00000031135.9_Missense_Mutation_p.R14P|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R794P|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R794P|BCLAF1_ENST00000392348.2_Missense_Mutation_p.R794P|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R796P|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R623P	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	796					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAAGGTTCCTCGTGGTCGGCT	0.358													48	77					0	0	1	0	0	G	136589310	C	G	136589310	3	3	38	1	0	0	0	0	1	0	0	0	1381	884	31	2	391	2	BCLAF1	6	136589310	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	48864181	136589310	34525757	16	3695										
BCLAF1	9774	broad.mit.edu	37	chr6	136597335	136597335	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tttctctattgcctttcagtGaaactttggacttgtacttg	7	8	2	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:136597335G>C	ENST00000531224.1	-	5	1580	c.1328C>G	c.(1327-1329)tCa>tGa	p.S443*	BCLAF1_ENST00000527759.1_Nonsense_Mutation_p.S441*|BCLAF1_ENST00000353331.4_Nonsense_Mutation_p.S441*|BCLAF1_ENST00000392348.2_Nonsense_Mutation_p.S441*|BCLAF1_ENST00000527536.1_Nonsense_Mutation_p.S443*|BCLAF1_ENST00000530767.1_Intron	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	443					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GCCTTTCAGTGAAACTTTGGA	0.398													32	135					0	0	1	0	0	C	136597335	G	C	136597335	4	2	38	1	0	0	0	0	0	1	0	0	1381	1294	45	2	1470	2	BCLAF1	6	136597335	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	8025	136597335	34517732	17	3696										
TNFAIP3	7128	broad.mit.edu	37	chr6	138200072	138200072	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gcacaacggattttgtgaacGttgccacaacgcccggcaac	10	13	0	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr6:138200072G>A	ENST00000237289.4	+	7	1556	c.1490G>A	c.(1489-1491)cGt>cAt	p.R497H		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	497	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TTTTGTGAACGTTGCCACAAC	0.597			"D, N, F"		"marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"								8	61					0	0	1	0	0	A	138200072	G	A	138200072	3	1	38	1	0	0	0	0	1	0	0	0	16333	1145	40	1	1512	1	TNFAIP3	6	138200072	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	1602737	138200072	32914995	18	3697										
DNAH11	8701	broad.mit.edu	37	chr7	21805153	21805153	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tggtttcatgcgtggccgcaGgaggctctggtctccgtcag	15	11	4	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:21805153G>A	ENST00000328843.6	+	56	9100	c.9069G>A	c.(9067-9069)caG>caA	p.Q3023Q	DNAH11_ENST00000409508.3_Silent_p.Q3016Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3023	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CGTGGCCGCAGGAGGCTCTGG	0.542									Kartagener syndrome				15	41					0	0	1	0	0	A	21805153	G	A	21805153	2	1	38	1	0	0	0	0	0	0	0	1	4627	991	35	3		3	DNAH11	7	21805153	Silent	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08		21805153	137333510	19	3698										
ZNF804B	219578	broad.mit.edu	37	chr7	88963677	88963677	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ctcttcaatggcctacggaaCttctgctctttacaaaaaca	5	12	4	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:88963677C>A	ENST00000333190.4	+	4	1990	c.1381C>A	c.(1381-1383)Ctt>Att	p.L461I		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	461						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GCCTACGGAACTTCTGCTCTT	0.423										HNSCC(36;0.09)			17	39					1.37285e-15	1.48268e-15	1	1	0	A	88963677	C	A	88963677	3	1	38	1	0	0	0	0	1	0	0	0	18219	565	20	5	1395	5	ZNF804B	7	88963677	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	67158524	88963677	70174986	20	3699										
PPP1R3A	5506	broad.mit.edu	37	chr7	113518497	113518497	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ctttgataattcttgaacctGcctaagatctctgttttctg	6	9	3	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:113518497G>A	ENST00000284601.3	-	4	2718	c.2650C>T	c.(2650-2652)Cag>Tag	p.Q884*		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	884					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TCTTGAACCTGCCTAAGATCT	0.368													9	48					0	0	1	0	0	A	113518497	G	A	113518497	4	1	38	1	0	0	0	0	0	1	0	0	12419	1328	46	3	722	3	PPP1R3A	7	113518497	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	24554820	113518497	45620166	21	3700										
GIMAP1	170575	broad.mit.edu	37	chr7	150417642	150417642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tggtggccgagtgcgggggcCgggtctgtgcctttgataac	18	9	1	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr7:150417642C>T	ENST00000307194.5	+	3	690	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCGGGGGCCGGGTCTGTGC	0.677													19	44					0	0	1	0	0	T	150417642	C	T	150417642	3	4	38	1	0	0	0	0	1	0	0	0	6420	643	23	1	556	1	GIMAP1	7	150417642	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	36899145	150417642	8721021	22	3701										
ZMAT4	79698	broad.mit.edu	37	chr8	40438702	40438702	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	acttggtctggtgtttagatCctttcagatgggcatgatac	11	7	2	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:40438702C>G	ENST00000297737.6	-	6	802	c.656G>C	c.(655-657)gGa>gCa	p.G219A	ZMAT4_ENST00000315769.7_Missense_Mutation_p.G143A	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	219						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			GTGTTTAGATCCTTTCAGATG	0.408													227	31					0	0	1	0	0	G	40438702	C	G	40438702	3	3	38	1	0	0	0	0	1	0	0	0	17751	855	30	2	41	2	ZMAT4	8	40438702	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08		40438702	105925320	23	3702										
HOOK3	84376	broad.mit.edu	37	chr8	42761327	42761327	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tcccttcagatccagacattTaatgtggatgcaccatgcca	7	12	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:42761327T>A	ENST00000307602.4	+	2	269	c.69T>A	c.(67-69)ttT>ttA	p.F23L		NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	23	Sufficient for interaction with microtubules.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			TCCAGACATTTAATGTGGATG	0.398			T	RET	papillary thyroid								8	290					0	0	1	0	0	A	42761327	T	A	42761327	3	1	38	1	0	0	0	0	1	0	0	0	7324	1751	61	4	75	4	HOOK3	8	42761327	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08	2322625	42761327	103602695	24	3703										
TOX	9760	broad.mit.edu	37	chr8	59851928	59851928	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tggagactgtgatttcagggAggtccatgttttgtggatga	15	4	1	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:59851928A>G	ENST00000361421.1	-	3	564	c.344T>C	c.(343-345)cTc>cCc	p.L115P		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	115						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GATTTCAGGGAGGTCCATGTT	0.478													8	141					0	0	1	0	0	G	59851928	A	G	59851928	3	3	38	1	0	0	0	0	1	0	0	0	16437	304	11	4	1264	4	TOX	8	59851928	Missense_Mutation	SNP	A	TCGA-N9-A4Q8-01A-31D-A28R-08	17090601	59851928	86512094	25	3704										
KIAA1429	25962	broad.mit.edu	37	chr8	95518910	95518910	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tgctccagttcagaaatagaAccttcagaagagcttggtaa	9	8	2	4			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:95518910A>T	ENST00000297591.5	-	16	3990	c.3915T>A	c.(3913-3915)ggT>ggA	p.G1305G	KIAA1429_ENST00000437199.1_Silent_p.G1305G	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1305					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CAGAAATAGAACCTTCAGAAG	0.393													19	132					0	0	1	0	0	T	95518910	A	T	95518910	2	4	38	1	0	0	0	0	0	0	0	1	8272	30	2	4		4	KIAA1429	8	95518910	Silent	SNP	A	TCGA-N9-A4Q8-01A-31D-A28R-08	35666982	95518910	50845112	26	3705										
ANXA13	312	broad.mit.edu	37	chr8	124693594	124693594	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tttgctttgatcccctgaagGtccacctgtagaaaaaataa	7	9	0	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:124693594G>T	ENST00000262219.6	-	12	1027	c.960C>A	c.(958-960)gaC>gaA	p.D320E	ANXA13_ENST00000419625.1_Missense_Mutation_p.D279E	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13	279					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			TCCCCTGAAGGTCCACCTGTA	0.438													48	294					3.77016e-25	4.30117e-25	1	1	0	T	124693594	G	T	124693594	3	4	38	1	0	0	0	0	1	0	0	0	711	1252	44	5	117	5	ANXA13	8	124693594	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	29174684	124693594	21670428	27	3706										
EPPK1	83481	broad.mit.edu	37	chr8	144941352	144941352	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ggctgtttccagtgggagccGgtggtggtgctgtgggtcga	20	7	0	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr8:144941352G>A	ENST00000525985.1	-	2	6141	c.6070C>T	c.(6070-6072)Cgg>Tgg	p.R2024W				P58107	EPIPL_HUMAN	epiplakin 1	2024						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGTGGGAGCCGGTGGTGGTGC	0.612													6	100					0	0	1	0	0	A	144941352	G	A	144941352	3	1	38	1	0	0	0	0	1	0	0	0	5218	1115	39	1	1196	1	EPPK1	8	144941352	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	20247758	144941352	1422670	28	3707										
IGFBPL1	347252	broad.mit.edu	37	chr9	38411522	38411522	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	atggcactggtacacaccctCatcctcctttcgcagggggt	10	14	1	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr9:38411522C>A	ENST00000377694.1	-	4	734	c.712G>T	c.(712-714)Gag>Tag	p.E238*		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	238	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		TACACACCCTCATCCTCCTTT	0.448													11	17					1.08611e-07	1.14253e-07	1	1	0	A	38411522	C	A	38411522	4	1	38	1	0	0	0	0	0	1	0	0	7628	835	29	2	128	2	IGFBPL1	9	38411522	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08		38411522	102801909	29	3708										
PCSK5	5125	broad.mit.edu	37	chr9	78790136	78790136	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cagaatggaatggaatggaaTgaaatggaatggaatgaaat	13	1	0	3	rs62556589		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr9:78790136T>C	ENST00000376767.3	+	14	2503	c.1991T>C	c.(1990-1992)aTg>aCg	p.M664T	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						tggaatggaatgaaatggaat	0.423													4	23					0	0	1	0	0	C	78790136	T	C	78790136	3	2	38	1	0	0	0	0	1	0	0	0	11649	1479	51	4		4	PCSK5	9	78790136	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08	40378614	78790136	62423295	30	3709										
ABCC2	1244	broad.mit.edu	37	chr10	101559103	101559103	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gctagtgaatgacatcttcaCgtttgtgagtcctcagctgc	10	10	3	3	rs149854486		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr10:101559103C>T	ENST00000370449.4	+	8	1120	c.1007C>T	c.(1006-1008)aCg>aTg	p.T336M		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	336	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GACATCTTCACGTTTGTGAGT	0.473													15	183					0	0	1	0	0	T	101559103	C	T	101559103	3	4	38	1	0	0	0	0	1	0	0	0	53	536	19	1	1037	1	ABCC2	10	101559103	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08		101559103	33975644	31	3710										
FAM24B	196792	broad.mit.edu	37	chr10	124608784	124608784	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cagaggccctcatttatgtcGcaacagcaaggtggcaggga	13	10	1	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr10:124608784G>A	ENST00000368898.3	-	4	554	c.264C>T	c.(262-264)tgC>tgT	p.C88C	FAM24B_ENST00000462859.1_5'UTR|CUZD1_ENST00000368904.1_5'UTR|FAM24B_ENST00000368896.1_Silent_p.C88C|CUZD1_ENST00000545804.1_Intron	NM_152644.2	NP_689857.2	Q8N5W8	FA24B_HUMAN	family with sequence similarity 24, member B	88						extracellular region				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.136)|COAD - Colon adenocarcinoma(40;0.141)		CATTTATGTCGCAACAGCAAG	0.448													14	41					0	0	1	0	0	A	124608784	G	A	124608784	2	1	38	1	0	0	0	0	0	0	0	1	5580	1079	38	1		1	FAM24B	10	124608784	Silent	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	23049681	124608784	10925963	32	3711										
RRM1	6240	broad.mit.edu	37	chr11	4123271	4123272	+	Frame_Shift_Del	DEL	AG	AG	-													0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	caaaattacatctcgaatccAgaagctttgttatggactca							TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:4123271_4123272delAG	ENST00000300738.5	+	2	272_273	c.68_69delAG	c.(67-69)cfs	p.Q23fs	RRM1_ENST00000423050.2_5'UTR	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	23	ATP-cone.				deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TCTCGAATCCAGAAGCTTTGTT	0.327													19	32	---	---	---	---						-	4123272	AG	-	4123271	7	5	38	1	0	1	0	1	0	0	0	0	13732	188	7	0	74	0	RRM1	11	4123271	Frame_Shift_Del	DEL	AG	TCGA-N9-A4Q8-01A-31D-A28R-08		4123271	130883245	33	3712										
GTF2H1	2965	broad.mit.edu	37	chr11	18369434	18369434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	acatggatggaaattccggaGatgcagactgctttcagcca	11	9	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:18369434G>C	ENST00000265963.4	+	9	1181	c.1021G>C	c.(1021-1023)Gat>Cat	p.D341H	GTF2H1_ENST00000534641.1_Missense_Mutation_p.D225H|GTF2H1_ENST00000524753.4_Missense_Mutation_p.D137H|GTF2H1_ENST00000530496.2_Missense_Mutation_p.D29H|GTF2H1_ENST00000453096.2_Missense_Mutation_p.D341H	NM_005316.3	NP_005307.1	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1, 62kDa	341					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	20						AAATTCCGGAGATGCAGACTG	0.393								Nucleotide excision repair (NER)					6	44					0	0	1	0	0	C	18369434	G	C	18369434	3	2	38	1	0	0	0	0	1	0	0	0	6900	942	33	2	1051	2	GTF2H1	11	18369434	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	14246163	18369434	116637082	34	3713										
C11orf1	64776	broad.mit.edu	37	chr11	111753232	111753232	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cgatgcaccactaatgagaaTacctattcaaaccgtaccct	5	13	1	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:111753232T>C	ENST00000260276.3	+	2	523	c.186T>C	c.(184-186)aaT>aaC	p.N62N	C11orf1_ENST00000530214.1_Silent_p.N62N|C11orf1_ENST00000528125.1_Silent_p.N16N|C11orf1_ENST00000529270.1_Silent_p.N102N	NM_022761.2	NP_073598.1	Q9H5F2	CK001_HUMAN	chromosome 11 open reading frame 1	62						nucleus				kidney(2)|lung(3)	5		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		CTAATGAGAATACCTATTCAA	0.463													10	27					0	0	1	0	0	C	111753232	T	C	111753232	2	2	38	1	0	0	0	0	0	0	0	1	1633	1403	49	4		4	C11orf1	11	111753232	Silent	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08	93383798	111753232	23253284	35	3714										
PKNOX2	63876	broad.mit.edu	37	chr11	125301240	125301240	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gaggtcgacgagctgcagacGacaaatgtcagcgacctggg	15	10	1	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr11:125301240G>A	ENST00000298282.9	+	13	1642	c.1371G>A	c.(1369-1371)acG>acA	p.T457T	PKNOX2_ENST00000530517.1_3'UTR|PKNOX2_ENST00000542175.1_Silent_p.T393T	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	457						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		AGCTGCAGACGACAAATGTCA	0.582													28	20					0	0	1	0	0	A	125301240	G	A	125301240	2	1	38	1	0	0	0	0	0	0	0	1	12030	1045	37	1		1	PKNOX2	11	125301240	Silent	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	13548008	125301240	9705276	36	3715										
ITGA5	3678	broad.mit.edu	37	chr12	54799462	54799462	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	actcacccatccccattgacGtctgtggcggccactgcata	8	16	2	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:54799462G>A	ENST00000293379.4	-	11	1263	c.1002C>T	c.(1000-1002)gaC>gaT	p.D334D	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	334					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CCCCATTGACGTCTGTGGCGG	0.547													43	35					0	0	1	0	0	A	54799462	G	A	54799462	2	1	38	1	0	0	0	0	0	0	0	1	7922	1136	40	1		1	ITGA5	12	54799462	Silent	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08		54799462	79052433	37	3716										
OR10A7	121364	broad.mit.edu	37	chr12	55615303	55615303	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cagacagcttggatgatggcCcttcctttctgtggaccaaa	10	11	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:55615303C>T	ENST00000326258.1	+	1	495	c.495C>T	c.(493-495)gcC>gcT	p.A165A		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						GGATGATGGCCCTTCCTTTCT	0.473													9	44					0	0	1	0	0	T	55615303	C	T	55615303	2	4	38	1	0	0	0	0	0	0	0	1	10942	610	22	3		3	OR10A7	12	55615303	Silent	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	815841	55615303	78236592	38	3717										
RPH3A	22895	broad.mit.edu	37	chr12	113285511	113285515	+	Frame_Shift_Del	DEL	GGCTG	GGCTG	-													0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ttcctttcaggctccaggcaGgctggtccgtccaccccggt							TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:113285511_113285515delGGCTG	ENST00000389385.4	+	5	591_595	c.94_98delGGCTG	c.(94-99)gfs	p.GW32fs	RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000415485.3_Frame_Shift_Del_p.GW32fs|RPH3A_ENST00000548866.1_Intron|RPH3A_ENST00000551052.1_Frame_Shift_Del_p.GW28fs|RPH3A_ENST00000420983.2_Frame_Shift_Del_p.GW32fs|RPH3A_ENST00000543106.2_Frame_Shift_Del_p.GW32fs	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	32					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCTCCAGGCAGGCTGGTCCGTCCAC	0.537													25	33	---	---	---	---						-	113285515	GGCTG	-	113285511	7	5	38	1	0	1	0	1	0	0	0	0	13602	1000	35	0	104	0	RPH3A	12	113285511	Frame_Shift_Del	DEL	GGCTG	TCGA-N9-A4Q8-01A-31D-A28R-08	57670208	113285511	20566384	39	3718										
NCOR2	9612	broad.mit.edu	37	chr12	124911256	124911256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	catggggtcggccataagccCgttcatgttgatgaacttga	12	9	1	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr12:124911256C>T	ENST00000356219.3	-	12	1395	c.1240G>A	c.(1240-1242)Ggg>Agg	p.G414R	NCOR2_ENST00000405201.1_Missense_Mutation_p.G414R|NCOR2_ENST00000429285.2_Missense_Mutation_p.G413R|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000404621.1_Missense_Mutation_p.G413R|NCOR2_ENST00000397355.1_Missense_Mutation_p.G414R	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	414					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCCATAAGCCCGTTCATGTTG	0.572													24	42					0	0	1	0	0	T	124911256	C	T	124911256	3	4	38	1	0	0	0	0	1	0	0	0	10282	652	23	1	6476	1	NCOR2	12	124911256	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	11625745	124911256	8940639	40	3719										
LCP1	3936	broad.mit.edu	37	chr13	46733004	46733004	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tccttccatcttggtccagaTcacctgtagccatcaggttt	7	13	3	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr13:46733004T>A	ENST00000398576.2	-	6	573	c.185A>T	c.(184-186)gAt>gTt	p.D62V	LCP1_ENST00000323076.2_Missense_Mutation_p.D62V			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	62	EF-hand 2.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTGGTCCAGATCACCTGTAGC	0.418			T	BCL6	NHL								70	57					0	0	1	0	0	A	46733004	T	A	46733004	3	1	38	1	0	0	0	0	1	0	0	0	8729	1435	50	4	1754	4	LCP1	13	46733004	Missense_Mutation	SNP	T	TCGA-N9-A4Q8-01A-31D-A28R-08		46733004	68436874	41	3720										
TGM5	9333	broad.mit.edu	37	chr15	43531185	43531185	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ccatcgaaaacacaaagggcGtgtcatagttcaggtccact	9	11	2	0	rs141830093		TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr15:43531185G>A	ENST00000220420.5	-	9	1182	c.1175C>T	c.(1174-1176)aCg>aTg	p.T392M	TGM5_ENST00000349114.4_Missense_Mutation_p.T310M	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	392					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CACAAAGGGCGTGTCATAGTT	0.557													4	40					0	0	1	0	0	A	43531185	G	A	43531185	3	1	38	1	0	0	0	0	1	0	0	0	15892	1145	40	1	1007	1	TGM5	15	43531185	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08		43531185	59000207	42	3721										
TP53	7157	broad.mit.edu	37	chr17	7573982	7573982	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	agcctgggcatccttgagttCcaaggcctcattcagctctc	9	14	3	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr17:7573982C>A	ENST00000269305.4	-	10	1234	c.1045G>T	c.(1045-1047)Gaa>Taa	p.E349*	TP53_ENST00000445888.2_Nonsense_Mutation_p.E349*|TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000455263.2_3'UTR|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	349	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		E -> D (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E349*(11)|p.0?(8)|p.L348_E349>F*(2)|p.E349fs*21(2)|p.?(1)|p.I332fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTGAGTTCCAAGGCCTCA	0.597		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	4					4.43304e-23	4.98716e-23	1	1	0	A	7573982	C	A	7573982	4	1	38	1	0	0	0	0	0	1	0	0	16441	864	30	2	144	2	TP53	17	7573982	Nonsense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08		7573982	73621228	43	3722										
SPOP	8405	broad.mit.edu	37	chr17	47696405	47696405	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ggcctcatccaaaagaaaatCtctacggatgaatttcttga	7	9	3	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr17:47696405C>A	ENST00000393331.3	-	7	888	c.418G>T	c.(418-420)Gat>Tat	p.D140Y	SPOP_ENST00000504102.1_Missense_Mutation_p.D140Y|SPOP_ENST00000503676.1_Missense_Mutation_p.D140Y|SPOP_ENST00000393328.2_Missense_Mutation_p.D140Y|SPOP_ENST00000347630.2_Missense_Mutation_p.D140Y	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	140	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.D140N(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						AAAAGAAAATCTCTACGGATG	0.463										Prostate(2;0.17)			108	9					1.85599e-38	2.14764e-38	1	1	0	A	47696405	C	A	47696405	3	1	38	1	0	0	0	0	1	0	0	0	15139	913	32	2	730	2	SPOP	17	47696405	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	40122423	47696405	33498805	44	3723										
GMIP	51291	broad.mit.edu	37	chr19	19741121	19741121	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gagactgtgtccccaggagtGagtcctctgggccttggctg	15	11	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr19:19741121G>C	ENST00000203556.4	-	21	2701	c.2564C>G	c.(2563-2565)tCa>tGa	p.S855*	GMIP_ENST00000445806.2_Nonsense_Mutation_p.S826*|GMIP_ENST00000587238.1_Nonsense_Mutation_p.S829*	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	855					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CCCCAGGAGTGAGTCCTCTGG	0.607													18	69					0	0	1	0	0	C	19741121	G	C	19741121	4	2	38	1	0	0	0	0	0	1	0	0	6532	1294	45	2	352	2	GMIP	19	19741121	Nonsense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08		19741121	39387862	45	3724										
TRPM4	54795	broad.mit.edu	37	chr19	49713575	49713575	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	cgctggccccgccctttatcGtcatctcccacttgcgcctc	7	20	2	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr19:49713575G>A	ENST00000252826.5	+	21	3367	c.3241G>A	c.(3241-3243)Gtc>Atc	p.V1081I	TRPM4_ENST00000427978.2_Missense_Mutation_p.V936I|TRPM4_ENST00000355712.5_Missense_Mutation_p.V727I	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	1081	Calmodulin-binding.				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GCCCTTTATCGTCATCTCCCA	0.642													13	130					0	0	1	0	0	A	49713575	G	A	49713575	3	1	38	1	0	0	0	0	1	0	0	0	16648	1145	40	1	3323	1	TRPM4	19	49713575	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	29972454	49713575	9415408	46	3725										
LILRA4	23547	broad.mit.edu	37	chr19	54848852	54848852	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	gggaggccatcggccccctcCttgtacagagtgtatctgat	12	12	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr19:54848852C>A	ENST00000291759.4	-	5	827	c.771G>T	c.(769-771)aaG>aaT	p.K257N		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	257	Ig-like C2-type 3.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CGGCCCCCTCCTTGTACAGAG	0.672													10	68					7.48243e-07	7.77021e-07	1	1	0	A	54848852	C	A	54848852	3	1	38	1	0	0	0	0	1	0	0	0	8826	680	24	5	744	5	LILRA4	19	54848852	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	5135277	54848852	4280131	47	3726										
CST2	1470	broad.mit.edu	37	chr20	23807168	23807168	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	aaagtgaagggcacgctgtaCccgctcatcattgaggtctg	12	10	3	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr20:23807168C>T	ENST00000304725.2	-	1	200	c.130G>A	c.(130-132)Gta>Ata	p.V44I		NM_001322.2	NP_001313.1	P09228	CYTT_HUMAN	cystatin SA	44						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|large_intestine(1)|liver(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	10						GCACGCTGTACCCGCTCATCA	0.592													29	37					0	0	1	0	0	T	23807168	C	T	23807168	3	4	38	1	0	0	0	0	1	0	0	0	3997	507	18	3	307	3	CST2	20	23807168	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08		23807168	39218352	48	3727										
GART	2618	broad.mit.edu	37	chr21	34878390	34878390	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ttggttcccgagtactgtctAtaagtgcttgcaggttcgat	11	8	1	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr21:34878390A>G	ENST00000381831.3	-	19	2737	c.2474T>C	c.(2473-2475)aTa>aCa	p.I825T	GART_ENST00000543717.1_Missense_Mutation_p.I377T|GART_ENST00000381839.3_Missense_Mutation_p.I825T|GART_ENST00000381815.4_Missense_Mutation_p.I825T	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	825	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	AGTACTGTCTATAAGTGCTTG	0.428													29	55					0	0	1	0	0	G	34878390	A	G	34878390	3	3	38	1	0	0	0	0	1	0	0	0	6282	449	16	4	574	4	GART	21	34878390	Missense_Mutation	SNP	A	TCGA-N9-A4Q8-01A-31D-A28R-08		34878390	13251505	49	3728										
BRWD1	54014	broad.mit.edu	37	chr21	40571181	40571181	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	ccgcaaatcactttctgactCtgagtctctgttttcagatt	6	11	5	3			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr21:40571181C>T	ENST00000342449.3	-	40	5239	c.5161G>A	c.(5161-5163)Gag>Aag	p.E1721K	BRWD1_ENST00000380800.3_Missense_Mutation_p.E1721K|BRWD1_ENST00000333229.2_Missense_Mutation_p.E1721K	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1721					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CTTTCTGACTCTGAGTCTCTG	0.398													35	48					0	0	1	0	0	T	40571181	C	T	40571181	3	4	38	1	0	0	0	0	1	0	0	0	1527	922	32	3	2052	3	BRWD1	21	40571181	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	5692791	40571181	7558714	50	3729										
U2AF1	7307	broad.mit.edu	37	chr21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tcggtttattgtgcaaccgaGagcacctgtctccatgacga	10	11	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr21:44524456G>A	ENST00000291552.4	-	2	193	c.101C>T	c.(100-102)tCt>tTt	p.S34F	U2AF1_ENST00000459639.1_5'UTR|U2AF1_ENST00000486519.1_5'UTR|U2AF1_ENST00000380276.2_Missense_Mutation_p.S34F|U2AF1_ENST00000398137.1_5'UTR	NM_006758.2	NP_006749.1	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	34					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding	p.S34F(45)|p.S34Y(12)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						GTGCAACCGAGAGCACCTGTC	0.358			Mis		"CLL, MDS"								13	26					0	0	1	0	0	A	44524456	G	A	44524456	3	1	38	1	0	0	0	0	1	0	0	0	16881	942	33	3	720	3	U2AF1	21	44524456	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	3953275	44524456	3605439	51	3730										
PKDREJ	10343	broad.mit.edu	37	chr22	46654307	46654307	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tgcaatacttgggtttattcGttctgaagcctgacaggagt	11	7	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chr22:46654307G>A	ENST00000253255.5	-	1	4912	c.4913C>T	c.(4912-4914)aCg>aTg	p.T1638M		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1638					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GGGTTTATTCGTTCTGAAGCC	0.393													9	37					0	0	1	0	0	A	46654307	G	A	46654307	3	1	38	1	0	0	0	0	1	0	0	0	12017	1145	40	1	1852	1	PKDREJ	22	46654307	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08		46654307	4650259	52	3731										
HUWE1	10075	broad.mit.edu	37	chrX	53674334	53674334	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	tatggaactgtacagatgccGggaaaagctgtactcaatga	11	7	1	2			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrX:53674334G>C	ENST00000342160.3	-	5	785	c.328C>G	c.(328-330)Cgg>Ggg	p.R110G	HUWE1_ENST00000262854.6_Missense_Mutation_p.R110G|HUWE1_ENST00000218328.8_Missense_Mutation_p.R110G			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	110					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TACAGATGCCGGGAAAAGCTG	0.438													25	26					0	0	1	0	0	C	53674334	G	C	53674334	3	2	38	1	0	0	0	0	1	0	0	0	7504	1115	39	5	13112	5	HUWE1	23	53674334	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08		53674334	101596226	53	3732										
ALAS2	212	broad.mit.edu	37	chrX	55042071	55042071	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	atcacgctccccaatcccagCgccccgggacccatacagtc	7	20	1	0			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrX:55042071C>T	ENST00000330807.5	-	8	1245	c.1108G>A	c.(1108-1110)Gct>Act	p.A370T	ALAS2_ENST00000335854.4_Missense_Mutation_p.A333T|ALAS2_ENST00000396198.3_Missense_Mutation_p.A357T|ALAS2_ENST00000498636.1_5'UTR	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	370					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	CCAATCCCAGCGCCCCGGGAC	0.527													27	53					0	0	1	0	0	T	55042071	C	T	55042071	3	4	38	1	0	0	0	0	1	0	0	0	482	768	27	1	671	1	ALAS2	23	55042071	Missense_Mutation	SNP	C	TCGA-N9-A4Q8-01A-31D-A28R-08	1367737	55042071	100228489	54	3733										
GPRASP2	114928	broad.mit.edu	37	chrX	101972267	101972267	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0909090909090909	5	1	1.14884696016771	2.95417789757412	0.599398414000547	1	1	0	agttagctaagcaactacaaGcccaaatagacaaccaaaat	5	10	0	1			TCGA-N9-A4Q8-01A-31D-A28R-08	TCGA-N9-A4Q8-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be7078d-fea8-4251-a3ce-61b557ea7d2a	0ff13793-87ed-4219-a372-f1cf13c2489e	g.chrX:101972267G>T	ENST00000543253.1	+	5	3389	c.2470G>T	c.(2470-2472)Gcc>Tcc	p.A824S	GPRASP2_ENST00000535209.1_Missense_Mutation_p.A824S|GPRASP2_ENST00000332262.5_Missense_Mutation_p.A824S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						GCAACTACAAGCCCAAATAGA	0.403													4	73					1.024e-07	1.09137e-07	1	1	0	T	101972267	G	T	101972267	3	4	38	1	0	0	0	0	1	0	0	0	6763	971	34	5	2472	5	GPRASP2	23	101972267	Missense_Mutation	SNP	G	TCGA-N9-A4Q8-01A-31D-A28R-08	46930196	101972267	53298293	55	3734										
THAP3	90326	broad.mit.edu	37	chr1	6692465	6692465	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcccaggtcctccctgaggcGggggccggagaggacagtcc	16	14	0	2	rs146637042	byFrequency	TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr1:6692465G>A	ENST00000377627.3	+	4	396	c.369G>A	c.(367-369)gcG>gcA	p.A123A	THAP3_ENST00000307896.6_Silent_p.A115A|THAP3_ENST00000054650.4_Silent_p.A116A	NM_138350.3	NP_612359.2	Q8WTV1	THAP3_HUMAN	THAP domain containing, apoptosis associated protein 3	116							DNA binding|metal ion binding			breast(1)|cervix(1)|large_intestine(1)|prostate(1)	4	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TCCCTGAGGCGGGGGCCGGAG	0.597													5	65					0	0	1	0	0	A	6692465	G	A	6692465	2	1	39	1	0	0	0	0	0	0	0	1	15904	1103	39	1		1	THAP3	1	6692465	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		6692465	242558156	1	3735										
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76877743	76877743	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	atagtgtcaaactcaggtcaGatggttggccagaaggtggg	15	6	3	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr1:76877743G>C	ENST00000328299.3	+	3	412	c.264G>C	c.(262-264)caG>caC	p.Q88H	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	88					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						ACTCAGGTCAGATGGTTGGCC	0.443													31	30					0	0	1	0	0	C	76877743	G	C	76877743	3	2	39	1	0	0	0	0	1	0	0	0	15280	933	33	2	274	2	ST6GALNAC3	1	76877743	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	70185278	76877743	172372878	2	3736										
LCE2C	353140	broad.mit.edu	37	chr1	152648727	152648727	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cctgagccaccacaggccccGtctcttccaccggcgccggc	10	21	1	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr1:152648727G>A	ENST00000368783.1	+	2	291	c.236G>A	c.(235-237)cGt>cAt	p.R79H	LCE2B_ENST00000417924.2_Intron	NM_178429.2	NP_848516.1	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	79	Cys-rich.				keratinization					endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	13	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACAGGCCCCGTCTCTTCCAC	0.682													127	132					0	0	1	0	0	A	152648727	G	A	152648727	3	1	39	1	0	0	0	0	1	0	0	0	8705	1145	40	1	238	1	LCE2C	1	152648727	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	75770984	152648727	96601894	3	3737										
CFH	3075	broad.mit.edu	37	chr1	196714954	196714954	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tgatgttttttagattctacAggaaaatgtgggccccctcc	9	9	1	2	rs1137971		TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr1:196714954A>G	ENST00000367429.4	+	21	3558	c.3318A>G	c.(3316-3318)acA>acG	p.T1106T		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	1106					complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TAGATTCTACAGGAAAATGTG	0.393													5	158					0	0	1	0	0	G	196714954	A	G	196714954	2	3	39	1	0	0	0	0	0	0	0	1	3305	175	7	4		4	CFH	1	196714954	Silent	SNP	A	TCGA-NA-A4QV-01A-11D-A28R-08	44066227	196714954	52535667	4	3738										
NRXN1	9378	broad.mit.edu	37	chr2	50723042	50723042	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tctgacttaacatgcacttaCtcttgaggtctaagttcctg	7	10	3	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr2:50723042C>A	ENST00000404971.1	-	16	4530		c.e16+1		NRXN1_ENST00000406316.2_Splice_Site|NRXN1_ENST00000406859.3_Splice_Site|NRXN1_ENST00000331040.5_Splice_Site|NRXN1_ENST00000402717.3_Splice_Site|NRXN1_ENST00000401710.1_Splice_Site|NRXN1_ENST00000405472.3_Splice_Site|NRXN1_ENST00000401669.2_Splice_Site	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1						adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATGCACTTACTCTTGAGGTC	0.473													18	7					2.35188e-11	2.52739e-11	1	1	0	A	50723042	C	A	50723042	5	1	39	1	0	0	0	0	0	0	1	0	10712	579	20	5	1751	5	NRXN1	2	50723042	Splice_Site	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08		50723042	192476331	5	3739										
DPP10	57628	broad.mit.edu	37	chr2	116593798	116593798	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	aagctttttaaatgtggatcCgtggttgcacctatcacaga	9	8	1	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr2:116593798C>T	ENST00000410059.1	+	22	2496	c.2016C>T	c.(2014-2016)tcC>tcT	p.S672S	DPP10_ENST00000393147.2_Silent_p.S676S|DPP10_ENST00000409163.1_Silent_p.S622S|DPP10_ENST00000310323.8_Silent_p.S665S	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	672					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AATGTGGATCCGTGGTTGCAC	0.328													8	20					0	0	1	0	0	T	116593798	C	T	116593798	2	4	39	1	0	0	0	0	0	0	0	1	4753	639	23	1		1	DPP10	2	116593798	Silent	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	65870756	116593798	126605575	6	3740										
POTEF	728378	broad.mit.edu	37	chr2	130833004	130833004	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	attcctttttttcacactttCaatatcctccaaatatttct	0	11	3	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr2:130833004C>T	ENST00000357462.5	-	15	2134	c.2041G>A	c.(2041-2043)Gaa>Aaa	p.E681K	POTEF_ENST00000361163.4_3'UTR|POTEF_ENST00000409914.2_Missense_Mutation_p.E681K|POTEF_ENST00000360967.5_3'UTR			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	681						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TTCACACTTTCAATATCCTCC	0.398													35	37					0	0	1	0	0	T	130833004	C	T	130833004	3	4	39	1	0	0	0	0	1	0	0	0	12311	835	29	3	1190	3	POTEF	2	130833004	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	14239206	130833004	112366369	7	3741										
RASGRF2	5924	broad.mit.edu	37	chr5	80476008	80476008	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cctaaggctttaacaacaccGagagaacatgtgataaagag	9	8	0	3			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr5:80476008G>A	ENST00000265080.4	+	18	2768	c.2701G>A	c.(2701-2703)Gag>Aag	p.E901K		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	901					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TAACAACACCGAGAGAACATG	0.443													22	107					0	0	1	0	0	A	80476008	G	A	80476008	3	1	39	1	0	0	0	0	1	0	0	0	13124	1059	37	1	2771	1	RASGRF2	5	80476008	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		80476008	100439252	8	3742										
DNAH8	1769	broad.mit.edu	37	chr6	38851677	38851677	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	aattgaaagctacgtggataAgcgaattggaagcacatatg	11	5	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr6:38851677A>C	ENST00000359357.3	+	54	7765	c.7511A>C	c.(7510-7512)aAg>aCg	p.K2504T	DNAH8_ENST00000441566.1_Missense_Mutation_p.K2468T|DNAH8_ENST00000449981.2_Missense_Mutation_p.K2721T					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TACGTGGATAAGCGAATTGGA	0.363													27	101					0	0	1	0	0	C	38851677	A	C	38851677	3	2	39	1	0	0	0	0	1	0	0	0	4634	72	3	4	7717	4	DNAH8	6	38851677	Missense_Mutation	SNP	A	TCGA-NA-A4QV-01A-11D-A28R-08		38851677	132263390	9	3743										
COL9A1	1297	broad.mit.edu	37	chr6	70964902	70964902	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	gaattcctctagcaccttcaGccccctgcagggaggaagag	11	13	2	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr6:70964902G>T	ENST00000357250.6	-	23	1720	c.1562C>A	c.(1561-1563)gCt>gAt	p.A521D	COL9A1_ENST00000370499.4_Missense_Mutation_p.A278D|COL9A1_ENST00000320755.7_Missense_Mutation_p.A278D|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	521	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGCACCTTCAGCCCCCTGCAG	0.448													7	128					0.00198382	0.00198382	1	1	0	T	70964902	G	T	70964902	3	4	39	1	0	0	0	0	1	0	0	0	3730	971	34	5	1267	5	COL9A1	6	70964902	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	32113225	70964902	100150165	10	3744										
HSPB1	3315	broad.mit.edu	37	chr7	75933345	75933345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ccaagtttcctcctccctgtCccctgagggcacactgaccg	8	18	0	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr7:75933345C>T	ENST00000248553.6	+	3	642	c.473C>T	c.(472-474)tCc>tTc	p.S158F	HSPB1_ENST00000429938.1_5'UTR	NM_001540.3	NP_001531.1	P04792	HSPB1_HUMAN	heat shock 27kDa protein 1	158	Interaction with TGFB1I1 (By similarity).				anti-apoptosis|cell death|cellular component movement|mRNA metabolic process|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor biosynthetic process|regulation of I-kappaB kinase/NF-kappaB cascade|regulation of translational initiation|response to heat|response to unfolded protein|response to virus	cell surface|cytosol|nucleus|proteasome complex|spindle	identical protein binding|protein kinase C delta binding|protein kinase C inhibitor activity|ubiquitin binding			large_intestine(1)|lung(3)	4						TCCTCCCTGTCCCCTGAGGGC	0.637													14	43					0	0	1	0	0	T	75933345	C	T	75933345	3	4	39	1	0	0	0	0	1	0	0	0	7460	855	30	3	483	3	HSPB1	7	75933345	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08		75933345	83205318	11	3745										
ARFGEF1	10565	broad.mit.edu	37	chr8	68204156	68204156	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tatcagatccattttcaggcTctgtgtcatcctgaagactt	7	10	4	3			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr8:68204156T>C	ENST00000262215.3	-	6	1231	c.842A>G	c.(841-843)gAg>gGg	p.E281G		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	281					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATTTTCAGGCTCTGTGTCATC	0.423													43	53					0	0	1	0	0	C	68204156	T	C	68204156	3	2	39	1	0	0	0	0	1	0	0	0	849	1551	54	4	4843	4	ARFGEF1	8	68204156	Missense_Mutation	SNP	T	TCGA-NA-A4QV-01A-11D-A28R-08		68204156	78159866	12	3746										
PCSK5	5125	broad.mit.edu	37	chr9	78790136	78790136	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cagaatggaatggaatggaaTgaaatggaatggaatgaaat	13	1	0	3	rs62556589		TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr9:78790136T>C	ENST00000376767.3	+	14	2503	c.1991T>C	c.(1990-1992)aTg>aCg	p.M664T	PCSK5_ENST00000545128.1_Intron|PCSK5_ENST00000376752.4_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						tggaatggaatgaaatggaat	0.423													3	20					0	0	1	0	0	C	78790136	T	C	78790136	3	2	39	1	0	0	0	0	1	0	0	0	11649	1479	51	4		4	PCSK5	9	78790136	Missense_Mutation	SNP	T	TCGA-NA-A4QV-01A-11D-A28R-08		78790136	62423295	13	3747										
RHOBTB1	9886	broad.mit.edu	37	chr10	62648275	62648275	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	aaatggggttgacttgcattTccctgtgcatgccaatgaac	10	9	0	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:62648275T>G	ENST00000337910.5	-	6	1488	c.1151A>C	c.(1150-1152)gAa>gCa	p.E384A	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.E384A	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	384	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					GACTTGCATTTCCCTGTGCAT	0.572													42	1867					0	0	1	0	0	G	62648275	T	G	62648275	3	3	39	1	0	0	0	0	1	0	0	0	13382	1783	62	4	963	4	RHOBTB1	10	62648275	Missense_Mutation	SNP	T	TCGA-NA-A4QV-01A-11D-A28R-08		62648275	72886472	14	3748										
TMEM26	219623	broad.mit.edu	37	chr10	63188798	63188798	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	gagtgatcccgcctccaatgGgtagaagccatcttccaatt	9	12	1	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:63188798G>T	ENST00000399298.3	-	4	859	c.491C>A	c.(490-492)cCc>cAc	p.P164H	TMEM26_ENST00000399293.1_Missense_Mutation_p.P164H	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	164						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					GCCTCCAATGGGTAGAAGCCA	0.423													25	831					1.1804e-14	1.28771e-14	1	1	0	T	63188798	G	T	63188798	3	4	39	1	0	0	0	0	1	0	0	0	16210	1232	43	5	627	5	TMEM26	10	63188798	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	540523	63188798	72345949	15	3749										
ZMIZ1	57178	broad.mit.edu	37	chr10	81067245	81067245	+	Frame_Shift_Del	DEL	C	C	-													0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tgaatgacttcatgcacgggCccccccagctctcccacccc							TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:81067245delC	ENST00000334512.5	+	23	3324	c.2752delC	c.(2752-2754)ccfs	p.P919fs	ZMIZ1_ENST00000446377.2_Frame_Shift_Del_p.P72fs	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	919	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CATGCACGGGCCCCCCCAGCT	0.597													7	571	---	---	---	---						-	81067245	C	-	81067245	7	5	39	1	0	1	0	1	0	0	0	0	17753	739	26	0	2826	0	ZMIZ1	10	81067245	Frame_Shift_Del	DEL	C	TCGA-NA-A4QV-01A-11D-A28R-08	17878447	81067245	54467502	16	3750										
ZMIZ1	57178	broad.mit.edu	37	chr10	81070787	81070789	+	In_Frame_Del	DEL	CTC	CTC	-													0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tccattacatcacagtggggCtcctcctcctcctccttccc							TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:81070787_81070789delCTC	ENST00000334512.5	+	24	3514_3516	c.2942_2944delCTC	c.(2941-2946)gct>g	p.AP981del	ZMIZ1_ENST00000446377.2_Intron	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	981	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CACAGTGGGGCTCCTCCTCCTCC	0.635													15	1209	---	---	---	---						-	81070789	CTC	-	81070787	7	5	39	1	0	1	0	1	0	0	0	0	17753	797	28	0	3020	0	ZMIZ1	10	81070787	In_Frame_Del	DEL	CTC	TCGA-NA-A4QV-01A-11D-A28R-08	3542	81070787	54463960	17	3751										
PGAM1	5223	broad.mit.edu	37	chr10	99190370	99190370	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ctatgatgtcccaccacctcCgatggagcccgaccatcctt	7	17	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:99190370C>T	ENST00000334828.5	+	2	522	c.374C>T	c.(373-375)cCg>cTg	p.P125L	PGAM1_ENST00000467867.1_3'UTR	NM_002629.2	NP_002620.1	P18669	PGAM1_HUMAN	phosphoglycerate mutase 1 (brain)	125	Pro-rich.				gluconeogenesis|glycolysis|regulation of glycolysis|regulation of pentose-phosphate shunt|respiratory burst	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein kinase binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)	6		Colorectal(252;0.162)		Epithelial(162;8.36e-10)|all cancers(201;5.62e-08)		CCACCACCTCCGATGGAGCCC	0.527													20	84					0	0	1	0	0	T	99190370	C	T	99190370	3	4	39	1	0	0	0	0	1	0	0	0	11820	652	23	1	380	1	PGAM1	10	99190370	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	18119583	99190370	36344377	18	3752										
BTRC	8945	broad.mit.edu	37	chr10	103190192	103190192	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tgtataacccagggactggcGcactcacagctttccaggta	10	12	1	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:103190192G>A	ENST00000370187.3	+	2	257	c.139G>A	c.(139-141)Gca>Aca	p.A47T	BTRC_ENST00000408038.2_Intron|BTRC_ENST00000393441.4_Missense_Mutation_p.A32T	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	47					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		AGGGACTGGCGCACTCACAGC	0.537													26	42					0	0	1	0	0	A	103190192	G	A	103190192	3	1	39	1	0	0	0	0	1	0	0	0	1572	1087	38	1	145	1	BTRC	10	103190192	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	3999822	103190192	32344555	19	3753										
OBFC1	79991	broad.mit.edu	37	chr10	105657468	105657468	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	agactggggaggtccagggcGcctggattgctgcggaggga	20	8	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:105657468G>A	ENST00000224950.3	-	7	758	c.591C>T	c.(589-591)ggC>ggT	p.G197G	OBFC1_ENST00000466828.1_5'UTR|OBFC1_ENST00000369764.1_Silent_p.G197G	NM_024928.4	NP_079204.2	Q9H668	STN1_HUMAN	oligonucleotide/oligosaccharide-binding fold containing 1	197					positive regulation of DNA replication|telomere maintenance via telomere lengthening		protein binding|single-stranded telomeric DNA binding			large_intestine(3)|lung(7)|ovary(1)|pancreas(2)	13		Colorectal(252;0.178)		Epithelial(162;3.39e-10)|all cancers(201;1.32e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0151)		GGTCCAGGGCGCCTGGATTGC	0.453													31	109					0	0	1	0	0	A	105657468	G	A	105657468	2	1	39	1	0	0	0	0	0	0	0	1	10854	1074	38	1		1	OBFC1	10	105657468	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	2467276	105657468	29877279	20	3754										
TACC2	10579	broad.mit.edu	37	chr10	123810033	123810033	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	aaaaggaagcagcaggacacGcccggaagccctgaccacag	12	13	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr10:123810033G>T	ENST00000369005.1	+	3	454	c.114G>T	c.(112-114)acG>acT	p.T38T	TACC2_ENST00000515273.1_Silent_p.T38T|TACC2_ENST00000453444.2_Silent_p.T38T|TACC2_ENST00000334433.3_Silent_p.T38T|TACC2_ENST00000515603.1_Silent_p.T38T|TACC2_ENST00000358010.1_Silent_p.T38T|TACC2_ENST00000513429.1_Silent_p.T38T	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	38						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGCAGGACACGCCCGGAAGCC	0.577													21	31					2.4624e-09	2.56946e-09	1	1	0	T	123810033	G	T	123810033	2	4	39	1	0	0	0	0	0	0	0	1	15558	1074	38	5		5	TACC2	10	123810033	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	18152565	123810033	11724714	21	3755										
OR6A2	8590	broad.mit.edu	37	chr11	6816677	6816677	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	gtccatgatcctgtttggatCcaacaaagccagcaagcatc	8	12	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr11:6816677C>G	ENST00000332601.3	-	1	451	c.263G>C	c.(262-264)gGa>gCa	p.G88A		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGTTTGGATCCAACAAAGCC	0.463													47	40					0	0	1	0	0	G	6816677	C	G	6816677	3	3	39	1	0	0	0	0	1	0	0	0	11232	855	30	2	724	2	OR6A2	11	6816677	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08		6816677	128189839	22	3756										
COPB1	1315	broad.mit.edu	37	chr11	14490350	14490350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcattcttagcagttagttgCatgaaggaaatggggtcatc	11	6	3	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr11:14490350C>T	ENST00000249923.3	-	16	2322	c.2022G>A	c.(2020-2022)atG>atA	p.M674I	COPB1_ENST00000439561.2_Missense_Mutation_p.M674I	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	674					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						CAGTTAGTTGCATGAAGGAAA	0.398													37	147					0	0	1	0	0	T	14490350	C	T	14490350	3	4	39	1	0	0	0	0	1	0	0	0	3751	710	25	3	867	3	COPB1	11	14490350	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	7673673	14490350	120516166	23	3757										
F2	2147	broad.mit.edu	37	chr11	46740793	46740794	+	Frame_Shift_Ins	INS	-	-	CGTC													0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	agctgacacactatggcgcaINScgtccgaggcttgcagctgc							TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr11:46740793_46740794insCGTC	ENST00000311907.5	+	1	64_65	c.8_9insCGTC	c.(7-9)cgtfs	p.R3fs	F2_ENST00000530231.1_Frame_Shift_Ins_p.R3fs	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	3					activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	ACTATGGCGCACGTCCGAGGCT	0.579													39	10	---	---	---	---						CGTC	46740794	-	CGTC	46740793	7	5	39	1	0	1	1	0	0	0	0	0	5370	159	6	0	10	0	F2	11	46740793	Frame_Shift_Ins	INS	-	TCGA-NA-A4QV-01A-11D-A28R-08	32250443	46740793	88265723	24	3758										
OR4D9	390199	broad.mit.edu	37	chr11	59282485	59282485	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tatttaccttcctgtttttgGtgtacatgacaactctaatg	6	8	1	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr11:59282485G>T	ENST00000329328.3	+	1	100	c.100G>T	c.(100-102)Gtg>Ttg	p.V34L		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						CCTGTTTTTGGTGTACATGAC	0.438													50	101					1.47099e-08	1.51302e-08	1	1	0	T	59282485	G	T	59282485	3	4	39	1	0	0	0	0	1	0	0	0	11106	1261	44	5	102	5	OR4D9	11	59282485	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	12541692	59282485	75724031	25	3759										
TMEM132A	54972	broad.mit.edu	37	chr11	60694716	60694716	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ctggaccctgtctacctgccGgcagccctggagctcctaga	11	16	1	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr11:60694716G>A	ENST00000005286.4	+	2	294	c.141G>A	c.(139-141)ccG>ccA	p.P47P	TMEM132A_ENST00000453848.2_Silent_p.P47P	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	47						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						TCTACCTGCCGGCAGCCCTGG	0.632													31	103					0	0	1	0	0	A	60694716	G	A	60694716	2	1	39	1	0	0	0	0	0	0	0	1	16104	1103	39	1		1	TMEM132A	11	60694716	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	1412231	60694716	74311800	26	3760										
CCDC88B	283234	broad.mit.edu	37	chr11	64109583	64109583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tgcagctggccaacgccaagGctcagctgcggcgtctgcgg	15	14	2	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr11:64109583G>A	ENST00000356786.5	+	8	837	c.793G>A	c.(793-795)Gct>Act	p.A265T	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	265					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CAACGCCAAGGCTCAGCTGCG	0.677													17	9					0	0	1	0	0	A	64109583	G	A	64109583	3	1	39	1	0	0	0	0	1	0	0	0	2884	1203	42	3	823	3	CCDC88B	11	64109583	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	3414867	64109583	70896933	27	3761										
DPY19L2	283417	broad.mit.edu	37	chr12	63974461	63974461	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cctgatgtggtactgtatttGatccactgtaaaagttcttc	8	8	1	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr12:63974461G>C	ENST00000324472.4	-	19	2064	c.1881C>G	c.(1879-1881)atC>atG	p.I627M	DPY19L2_ENST00000413230.2_Missense_Mutation_p.I74M	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	627					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TACTGTATTTGATCCACTGTA	0.318													20	100					0	0	1	0	0	C	63974461	G	C	63974461	3	2	39	1	0	0	0	0	1	0	0	0	4767	1280	45	2	411	2	DPY19L2	12	63974461	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		63974461	69877434	28	3762			1	7		3	3	112	G		1.857406e-08
DPY19L2	283417	broad.mit.edu	37	chr12	63974520	63974520	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ttctcctattatgctccattGattacggaggtttgcataac	7	9	1	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr12:63974520G>C	ENST00000324472.4	-	19	2005	c.1822C>G	c.(1822-1824)Caa>Gaa	p.Q608E	DPY19L2_ENST00000413230.2_Missense_Mutation_p.Q55E	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	608					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		ATGCTCCATTGATTACGGAGG	0.373													15	93					0	0	1	0	0	C	63974520	G	C	63974520	3	2	39	1	0	0	0	0	1	0	0	0	4767	1299	45	2	470	2	DPY19L2	12	63974520	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	59	63974520	69877375	29	3763			1	7		3	3	112	G		1.857406e-08
DPY19L2	283417	broad.mit.edu	37	chr12	63974572	63974572	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	atcactgttaaaatgccaaaGataaccttctcaaaacgaac	4	10	2	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr12:63974572G>C	ENST00000324472.4	-	19	1953	c.1770C>G	c.(1768-1770)atC>atG	p.I590M	DPY19L2_ENST00000413230.2_Missense_Mutation_p.I37M	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	590					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AAATGCCAAAGATAACCTTCT	0.373													18	77					0	0	1	0	0	C	63974572	G	C	63974572	3	2	39	1	0	0	0	0	1	0	0	0	4767	932	33	2	522	2	DPY19L2	12	63974572	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	52	63974572	69877323	30	3764			1	7		3	3	112	G		1.857406e-08
NAV3	89795	broad.mit.edu	37	chr12	78362441	78362441	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	actcacgcttcccctccatcGgaagccagccaggccaaaac	7	18	1	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr12:78362441G>A	ENST00000397909.2	+	5	803	c.630G>A	c.(628-630)tcG>tcA	p.S210S	NAV3_ENST00000536525.2_Silent_p.S210S|NAV3_ENST00000228327.6_Silent_p.S210S|NAV3_ENST00000266692.7_Silent_p.S210S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	210			S -> W (in dbSNP:rs34195711).			nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCCCTCCATCGGAAGCCAGCC	0.458										HNSCC(70;0.22)			18	34					0	0	1	0	0	A	78362441	G	A	78362441	2	1	39	1	0	0	0	0	0	0	0	1	10232	1103	39	1		1	NAV3	12	78362441	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	14387869	78362441	55489454	31	3765										
MYBPC1	4604	broad.mit.edu	37	chr12	102046898	102046898	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tgcttaatattctagatcctCctaagatcatcctggatggt	7	9	2	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr12:102046898C>A	ENST00000549145.1	+	17	1703	c.1603C>A	c.(1603-1605)Cct>Act	p.P535T	MYBPC1_ENST00000545503.2_Missense_Mutation_p.P522T|MYBPC1_ENST00000553190.1_Missense_Mutation_p.P522T|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000551300.1_Missense_Mutation_p.P423T|MYBPC1_ENST00000541119.1_Missense_Mutation_p.P510T|MYBPC1_ENST00000550270.1_Missense_Mutation_p.P522T|MYBPC1_ENST00000536007.1_Missense_Mutation_p.P503T|MYBPC1_ENST00000452455.2_Missense_Mutation_p.P522T|MYBPC1_ENST00000547509.1_Missense_Mutation_p.P508T|MYBPC1_ENST00000547405.1_Missense_Mutation_p.P496T|RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000441232.1_Missense_Mutation_p.P522T|MYBPC1_ENST00000361685.2_Missense_Mutation_p.P547T|MYBPC1_ENST00000392934.3_Missense_Mutation_p.P509T|MYBPC1_ENST00000361466.2_Missense_Mutation_p.P547T|MYBPC1_ENST00000360610.2_Missense_Mutation_p.P522T			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	522	Ig-like C2-type 5.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						TCTAGATCCTCCTAAGATCAT	0.413													24	18					5.45024e-15	6.03719e-15	1	1	0	A	102046898	C	A	102046898	3	1	39	1	0	0	0	0	1	0	0	0	10058	855	30	2	1709	2	MYBPC1	12	102046898	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	23684457	102046898	31804997	32	3766										
ULK1	8408	broad.mit.edu	37	chr12	132405699	132405699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	accgtgagggctgcgtcccaCgctaccacaaggccctgctg	12	16	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr12:132405699C>T	ENST00000321867.4	+	27	3367	c.3016C>T	c.(3016-3018)Cgc>Tgc	p.R1006C	ULK1_ENST00000540647.1_Missense_Mutation_p.R251C	NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	1006					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity	p.R1006C(1)		breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CTGCGTCCCACGCTACCACAA	0.672													20	39					0	0	1	0	0	T	132405699	C	T	132405699	3	4	39	1	0	0	0	0	1	0	0	0	17034	536	19	1	3122	1	ULK1	12	132405699	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	30358801	132405699	1446196	33	3767										
TRMT5	57570	broad.mit.edu	37	chr14	61447758	61447758	+	Translation_Start_Site	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcacctcccgctccggtaccGatcggatgtgggtcgcgggt	14	14	1	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr14:61447758G>C	ENST00000261249.6	-	0	318				RP11-193F5.1_ENST00000553946.1_RNA	NM_020810.2	NP_065861.2	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5							cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(1)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		CTCCGGTACCGATCGGATGTG	0.637													33	26					0	0	1	0	0	C	61447758	G	C	61447758	1	2	39	1	0	0	0	0	0	0	0	0	16627	1073	37	2		2	TRMT5	14	61447758	Translation_Start_Site	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		61447758	45901782	34	3768										
ZFP36L1	677	broad.mit.edu	37	chr14	69256296	69256296	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tgaagatgggcaggcgtcttGagttgtccaaggtcggggag	18	6	1	3			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr14:69256296G>C	ENST00000439696.2	-	2	1272	c.971C>G	c.(970-972)tCa>tGa	p.S324*	ZFP36L1_ENST00000336440.3_Nonsense_Mutation_p.S324*|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	324					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CAGGCGTCTTGAGTTGTCCAA	0.607											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	104	86					0	0	1	0	0	C	69256296	G	C	69256296	4	2	39	1	0	0	0	0	0	1	0	0	17703	1294	45	2	49	2	ZFP36L1	14	69256296	Nonsense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	7808538	69256296	38093244	35	3769										
DYNC1H1	1778	broad.mit.edu	37	chr14	102455116	102455116	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcttcttggacaagctgaagAtaaagcagaagttgacatgg	11	6	2	4			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr14:102455116A>G	ENST00000360184.4	+	10	2959	c.2795A>G	c.(2794-2796)gAt>gGt	p.D932G		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	932	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CAAGCTGAAGATAAAGCAGAA	0.458													43	30					0	0	1	0	0	G	102455116	A	G	102455116	3	3	39	1	0	0	0	0	1	0	0	0	4867	333	12	4	2833	4	DYNC1H1	14	102455116	Missense_Mutation	SNP	A	TCGA-NA-A4QV-01A-11D-A28R-08	33198820	102455116	4894424	36	3770										
PML	5371	broad.mit.edu	37	chr15	74336610	74336610	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	gaaccgggaaagcaagttccGcgtggtcatccagcctgaag	13	11	1	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr15:74336610G>C	ENST00000565898.1	+	8	1850	c.1766G>C	c.(1765-1767)cGc>cCc	p.R589P	PML_ENST00000268058.3_Missense_Mutation_p.R637P			P29590	PML_HUMAN	promyelocytic leukemia	637					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						AGCAAGTTCCGCGTGGTCATC	0.612			T	"RARA, PAX5"	"APL, ALL"								25	94					0	0	1	0	0	C	74336610	G	C	74336610	3	2	39	1	0	0	0	0	1	0	0	0	12182	1087	38	5	2961	5	PML	15	74336610	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		74336610	28194782	37	3771										
DNAJA2	10294	broad.mit.edu	37	chr16	46993254	46993254	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ccatcaaggtgcttaaatgtGaactgaaatccacatagagc	8	9	1	3			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr16:46993254G>A	ENST00000317089.5	-	7	1067	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_005880.3	NP_005871.1	O60884	DNJA2_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 2	284					positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	14		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				GCTTAAATGTGAACTGAAATC	0.368													45	46					0	0	1	0	0	A	46993254	G	A	46993254	2	1	39	1	0	0	0	0	0	0	0	1	4639	1281	45	3		3	DNAJA2	16	46993254	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		46993254	43361499	38	3772										
HP	3240	broad.mit.edu	37	chr16	72094680	72094680	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ggaggaggacacctggtatgCgactgggatcttaagctttg	15	7	1	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr16:72094680C>G	ENST00000355906.5	+	7	1170	c.1112C>G	c.(1111-1113)gCg>gGg	p.A371G	HP_ENST00000570083.1_Missense_Mutation_p.A312G|HP_ENST00000565574.1_Missense_Mutation_p.A312G|HP_ENST00000398131.2_Missense_Mutation_p.A312G|HP_ENST00000562526.1_3'UTR|HPR_ENST00000356967.5_Intron	NM_005143.3	NP_005134.1	P00738	HPT_HUMAN	haptoglobin	371	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		ACCTGGTATGCGACTGGGATC	0.522													38	153					0	0	1	0	0	G	72094680	C	G	72094680	3	3	39	1	0	0	0	0	1	0	0	0	7367	768	27	5	1138	5	HP	16	72094680	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	25101426	72094680	18260073	39	3773										
TP53	7157	broad.mit.edu	37	chr17	7578236	7578236	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	agtgtttctgtcatccaaatActccacacgcaaatttcctt	4	12	2	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr17:7578236A>T	ENST00000420246.2	-	6	745	c.613T>A	c.(613-615)Tat>Aat	p.Y205N	TP53_ENST00000455263.2_Missense_Mutation_p.Y205N|TP53_ENST00000359597.4_Missense_Mutation_p.Y205N|TP53_ENST00000269305.4_Missense_Mutation_p.Y205N|TP53_ENST00000413465.2_Missense_Mutation_p.Y205N|TP53_ENST00000445888.2_Missense_Mutation_p.Y205N|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	205	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205D(13)|p.0?(8)|p.Y205N(8)|p.?(5)|p.Y205H(5)|p.Y112N(2)|p.Y73N(2)|p.Y205fs*43(1)|p.Y205fs*42(1)|p.E204fs*39(1)|p.G199fs*42(1)|p.E204_N210delEYLDDRN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCATCCAAATACTCCACACGC	0.542		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			46	6					0	0	1	0	0	T	7578236	A	T	7578236	3	4	39	1	0	0	0	0	1	0	0	0	16441	391	14	4	681	4	TP53	17	7578236	Missense_Mutation	SNP	A	TCGA-NA-A4QV-01A-11D-A28R-08		7578236	73616974	40	3774										
PFAS	5198	broad.mit.edu	37	chr17	8157385	8157385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	agactgaactgtgctacaacGtgaactggacaggttgggcc	13	9	0	3			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr17:8157385G>A	ENST00000314666.6	+	2	263	c.130G>A	c.(130-132)Gtg>Atg	p.V44M	PFAS_ENST00000545834.1_5'UTR	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	44					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTGCTACAACGTGAACTGGAC	0.602													47	63					0	0	1	0	0	A	8157385	G	A	8157385	3	1	39	1	0	0	0	0	1	0	0	0	11801	1145	40	1	132	1	PFAS	17	8157385	Missense_Mutation	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	579149	8157385	73037825	41	3775										
TMEM132E	124842	broad.mit.edu	37	chr17	32963037	32963037	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ctgcctcaggtggtgtctccGctgacggaggctgtgctcgg	16	12	2	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr17:32963037G>A	ENST00000321639.5	+	9	2047	c.1719G>A	c.(1717-1719)ccG>ccA	p.P573P		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	573						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		TGGTGTCTCCGCTGACGGAGG	0.652													8	7					0	0	1	0	0	A	32963037	G	A	32963037	2	1	39	1	0	0	0	0	0	0	0	1	16107	1074	38	1		1	TMEM132E	17	32963037	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08	24805652	32963037	48232173	42	3776										
DTNA	1837	broad.mit.edu	37	chr18	32409007	32409007	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cattttatatcatttcagctCggacggtgcttttggtggat	10	7	2	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr18:32409007C>T	ENST00000315456.6	+	13	1421	c.1097C>T	c.(1096-1098)tCg>tTg	p.S366L	DTNA_ENST00000399121.5_Intron|DTNA_ENST00000269191.6_Intron|DTNA_ENST00000595022.1_Intron|DTNA_ENST00000269190.7_Intron|DTNA_ENST00000599844.1_Intron|DTNA_ENST00000399113.3_Intron|DTNA_ENST00000269192.7_Intron|DTNA_ENST00000283365.9_Intron|DTNA_ENST00000598334.1_Intron|DTNA_ENST00000597674.1_Intron|DTNA_ENST00000554864.3_Missense_Mutation_p.S363L|DTNA_ENST00000598142.1_Intron|DTNA_ENST00000598774.1_Intron|DTNA_ENST00000597599.1_Intron|DTNA_ENST00000591182.1_Intron|DTNA_ENST00000556414.3_Intron|DTNA_ENST00000348997.5_Intron|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000399097.3_Intron|DTNA_ENST00000444659.1_Intron|DTNA_ENST00000601125.1_Intron	NM_001392.4	NP_001383.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	366					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						CATTTCAGCTCGGACGGTGCT	0.398													23	28					0	0	1	0	0	T	32409007	C	T	32409007	3	4	39	1	0	0	0	0	1	0	0	0	4814	893	31	1	1139	1	DTNA	18	32409007	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08		32409007	45668241	43	3777										
ZNF407	55628	broad.mit.edu	37	chr18	72343750	72343750	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	agtgttcagaagaaaacttgTtgaatgcacattatcttggc	9	6	2	3			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr18:72343750T>A	ENST00000299687.5	+	1	775	c.775T>A	c.(775-777)Ttg>Atg	p.L259M	ZNF407_ENST00000309902.6_Missense_Mutation_p.L259M|ZNF407_ENST00000577538.1_Missense_Mutation_p.L259M|ZNF407_ENST00000582337.1_Missense_Mutation_p.L259M	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGAAAACTTGTTGAATGCACA	0.413													39	58					0	0	1	0	0	A	72343750	T	A	72343750	3	1	39	1	0	0	0	0	1	0	0	0	17943	1722	60	4	777	4	ZNF407	18	72343750	Missense_Mutation	SNP	T	TCGA-NA-A4QV-01A-11D-A28R-08	39934743	72343750	5733498	44	3778										
MAG	4099	broad.mit.edu	37	chr19	35804291	35804291	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cactcggacctggggaaacgGcccaccaaggacagctacac	11	15	0	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr19:35804291G>T	ENST00000392213.3	+	11	1974	c.1815G>T	c.(1813-1815)cgG>cgT	p.R605R	MAG_ENST00000361922.4_3'UTR|MAG_ENST00000537831.2_Silent_p.R580R	NM_002361.3	NP_002352.1	P20916	MAG_HUMAN	myelin associated glycoprotein	605					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TGGGGAAACGGCCCACCAAGG	0.642													105	72					1.21621e-70	1.38995e-70	1	1	0	T	35804291	G	T	35804291	2	4	39	1	0	0	0	0	0	0	0	1	9207	1190	42	5		5	MAG	19	35804291	Silent	SNP	G	TCGA-NA-A4QV-01A-11D-A28R-08		35804291	23324692	45	3779										
SIPA1L3	23094	broad.mit.edu	37	chr19	38633333	38633333	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcggccacctacgtgagataCaagccatccccagaaaggtc	9	14	0	2			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr19:38633333C>G	ENST00000222345.6	+	12	4025	c.3516C>G	c.(3514-3516)taC>taG	p.Y1172*		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1172					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACGTGAGATACAAGCCATCCC	0.567											OREG0025445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	322	248					0	0	1	0	0	G	38633333	C	G	38633333	4	3	39	1	0	0	0	0	0	1	0	0	14385	489	17	5	3554	5	SIPA1L3	19	38633333	Nonsense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	2829042	38633333	20495650	46	3780										
MEGF8	1954	broad.mit.edu	37	chr19	42880633	42880633	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	gggccctggggacccatgggAgggggctgctgcccaccagc	18	14	0	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr19:42880633A>G	ENST00000334370.4	+	41	8678	c.8043A>G	c.(8041-8043)ggA>ggG	p.G2681G	MEGF8_ENST00000378073.4_Silent_p.G342G|MEGF8_ENST00000251268.6_Silent_p.G2748G	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2748						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GACCCATGGGAGGGGGCTGCT	0.721													5	8					0	0	1	0	0	G	42880633	A	G	42880633	2	3	39	1	0	0	0	0	0	0	0	1	9512	291	11	4		4	MEGF8	19	42880633	Silent	SNP	A	TCGA-NA-A4QV-01A-11D-A28R-08	4247300	42880633	16248350	47	3781										
WFDC8	90199	broad.mit.edu	37	chr20	44180764	44180764	+	Frame_Shift_Del	DEL	G	G	-													0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	cacttgggtttatcaatcttGgtacatagcaagggcttgcg							TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr20:44180764delG	ENST00000357199.4	-	6	705	c.627delC	c.(625-627)acfs	p.T209fs	WFDC8_ENST00000289953.2_Frame_Shift_Del_p.T209fs	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	209	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				TATCAATCTTGGTACATAGCA	0.433													56	68	---	---	---	---						-	44180764	G	-	44180764	7	5	39	1	0	1	0	1	0	0	0	0	17415	1335	47	0	102	0	WFDC8	20	44180764	Frame_Shift_Del	DEL	G	TCGA-NA-A4QV-01A-11D-A28R-08		44180764	18844756	48	3782										
SYCP2	10388	broad.mit.edu	37	chr20	58489052	58489052	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcttttgtctccaagcatgcCatttacaaggttgagaaata	7	8	2	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr20:58489052C>A	ENST00000357552.3	-	12	1033	c.808G>T	c.(808-810)Ggc>Tgc	p.G270C	SYCP2_ENST00000371001.2_Missense_Mutation_p.G270C			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	270					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			CCAAGCATGCCATTTACAAGG	0.299													10	10					2.74318e-10	2.90454e-10	1	1	0	A	58489052	C	A	58489052	3	1	39	1	0	0	0	0	1	0	0	0	15488	594	21	5	3920	5	SYCP2	20	58489052	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	14308288	58489052	4536468	49	3783										
GABPA	2551	broad.mit.edu	37	chr21	27141432	27141432	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	gcggagttgaaccgtttggtCacagaatgtgaacagaagaa	13	6	1	5			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr21:27141432C>T	ENST00000354828.3	+	10	1781	c.1254C>T	c.(1252-1254)gtC>gtT	p.V418V	GABPA_ENST00000400075.3_Silent_p.V418V	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	418					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						ACCGTTTGGTCACAGAATGTG	0.443													35	114					0	0	1	0	0	T	27141432	C	T	27141432	2	4	39	1	0	0	0	0	0	0	0	1	6191	813	29	3		3	GABPA	21	27141432	Silent	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08		27141432	20988463	50	3784										
LSS	4047	broad.mit.edu	37	chr21	47614430	47614430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	ggccatcagccccatcatggCccagcatgtgttatggatct	10	13	3	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chr21:47614430C>T	ENST00000397728.3	-	20	2041	c.1963G>A	c.(1963-1965)Gcc>Acc	p.A655T	LSS_ENST00000522411.1_Missense_Mutation_p.A644T|LSS_ENST00000457828.2_Missense_Mutation_p.A575T|LSS_ENST00000356396.4_Missense_Mutation_p.A655T	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	655					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					CCCATCATGGCCCAGCATGTG	0.637													22	31					0	0	1	0	0	T	47614430	C	T	47614430	3	4	39	1	0	0	0	0	1	0	0	0	9109	739	26	3	247	3	LSS	21	47614430	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08	20472998	47614430	515465	51	3785										
TBC1D25	4943	broad.mit.edu	37	chrX	48418348	48418348	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	catggaccatgagggccatgCctttgtttgcttttgtggca	12	9	0	1			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chrX:48418348C>A	ENST00000376771.4	+	6	1393	c.1052C>A	c.(1051-1053)gCc>gAc	p.A351D	TBC1D25_ENST00000427713.1_3'UTR|TBC1D25_ENST00000537536.1_Missense_Mutation_p.A97D	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	351	Rab-GAP TBC.					intracellular	Rab GTPase activator activity	p.A351G(1)		large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GAGGGCCATGCCTTTGTTTGC	0.582													27	10					9.86323e-18	1.10961e-17	1	1	0	A	48418348	C	A	48418348	3	1	39	1	0	0	0	0	1	0	0	0	15671	739	26	5	1074	5	TBC1D25	23	48418348	Missense_Mutation	SNP	C	TCGA-NA-A4QV-01A-11D-A28R-08		48418348	106852212	52	3786										
DGKK	139189	broad.mit.edu	37	chrX	50165595	50165596	+	RNA	INS	-	-	AC													0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	aaagagacattaaaaggtaaINSacacacacacacacacacac					rs59226442		TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chrX:50165595_50165596insAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTAAAAGGTAAacacacacaca	0.411													6	4	---	---	---	---						AC	50165596	-	AC	50165595	6	5	39	0	1	1	1	0	0	0	0	0	4500	29	1	0		0	DGKK	23	50165595	RNA	INS	-	TCGA-NA-A4QV-01A-11D-A28R-08	1747247	50165595	105104965	53	3787										
HCFC1	3054	broad.mit.edu	37	chrX	153230117	153230117	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.148148148148148	8	0.401168445648911	2.2258064516129	4.17338709677419	1.25201612903226	0.619269619269619	1	0	tcccgtcacacacgaagccaTaggctgcacacccaggggga	11	15	1	0			TCGA-NA-A4QV-01A-11D-A28R-08	TCGA-NA-A4QV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8598452d-d3c0-4c2e-b090-53cba35fb1dc	35e196fa-e68d-4353-b327-f166bcea7ced	g.chrX:153230117T>C	ENST00000310441.7	-	2	1220	c.254A>G	c.(253-255)tAt>tGt	p.Y85C	HCFC1_ENST00000354233.3_Missense_Mutation_p.Y85C|HCFC1_ENST00000369984.4_Missense_Mutation_p.Y85C	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	85					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACGAAGCCATAGGCTGCACA	0.582											OREG0003629	type=REGULATORY REGION|Gene=HCFC1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	60	17					0	0	1	0	0	C	153230117	T	C	153230117	3	2	39	1	0	0	0	0	1	0	0	0	7031	1406	49	4	5953	4	HCFC1	23	153230117	Missense_Mutation	SNP	T	TCGA-NA-A4QV-01A-11D-A28R-08	103064522	153230117	2040443	54	3788										
UBR4	23352	broad.mit.edu	37	chr1	19493718	19493718	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ctgtggtgggttcatctcatCtgaccaacttcagcaaagaa	9	10	4	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:19493718C>G	ENST00000375267.2	-	29	3910	c.3907G>C	c.(3907-3909)Gat>Cat	p.D1303H	UBR4_ENST00000375254.3_Missense_Mutation_p.D1303H|UBR4_ENST00000375217.2_Missense_Mutation_p.D1303H|UBR4_ENST00000375226.2_Missense_Mutation_p.D1303H			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	1303					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTCATCTCATCTGACCAACTT	0.458													20	26					0	0	1	0	0	G	19493718	C	G	19493718	3	3	40	1	0	0	0	0	1	0	0	0	16964	913	32	2	11956	2	UBR4	1	19493718	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		19493718	229756903	1	3789										
GBP5	115362	broad.mit.edu	37	chr1	89730615	89730615	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ggcagatccccactgctgatGgcattgacataggtcagcac	11	12	1	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:89730615G>A	ENST00000343435.5	-	8	1439	c.903C>T	c.(901-903)gcC>gcT	p.A301A	GBP5_ENST00000481145.1_5'UTR|RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000370459.3_Silent_p.A301A	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	301						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CACTGCTGATGGCATTGACAT	0.443													23	42					0	0	1	0	0	A	89730615	G	A	89730615	2	1	40	1	0	0	0	0	0	0	0	1	6316	1335	47	3		3	GBP5	1	89730615	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	70236897	89730615	159520006	2	3790										
HIPK1	204851	broad.mit.edu	37	chr1	114483989	114483989	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	atgctggttgatccagttcgCcagccctaccgagtgaaggt	12	11	0	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:114483989C>A	ENST00000369558.1	+	2	1216	c.984C>A	c.(982-984)cgC>cgA	p.R328R	HIPK1_ENST00000426820.2_Silent_p.R328R|HIPK1_ENST00000369555.2_Silent_p.R328R|HIPK1_ENST00000369554.2_Silent_p.R328R|HIPK1_ENST00000369559.4_Silent_p.R328R|HIPK1_ENST00000369561.4_Silent_p.R328R			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	328	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCCAGTTCGCCAGCCCTACC	0.502													21	100					9.57634e-11	9.95939e-11	1	1	0	A	114483989	C	A	114483989	2	1	40	1	0	0	0	0	0	0	0	1	7156	726	26	5		5	HIPK1	1	114483989	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	24753374	114483989	134766632	3	3791										
NBPF15	284565	broad.mit.edu	37	chr1	148594544	148594544	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tactcatttgaggaagagcaTatcagcttcgccctttacgt	8	10	2	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:148594544T>C	ENST00000442702.2	+	21	2984	c.1917T>C	c.(1915-1917)caT>caC	p.H639H	NBPF15_ENST00000369187.3_Silent_p.H639H	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	639	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					AGGAAGAGCATATCAGCTTCG	0.433													5	242					0	0	1	0	0	C	148594544	T	C	148594544	2	2	40	1	0	0	0	0	0	0	0	1	10242	1403	49	4		4	NBPF15	1	148594544	Silent	SNP	T	TCGA-NA-A4QW-01A-11D-A28R-08	34110555	148594544	100656077	4	3792										
OTUD7B	56957	broad.mit.edu	37	chr1	149916917	149916917	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gactcaggagtggaccggggCtcatctccagctgaggcggt	16	11	3	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:149916917C>A	ENST00000369135.3	-	12	1665	c.1371G>T	c.(1369-1371)gaG>gaT	p.E457D		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	457					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TGGACCGGGGCTCATCTCCAG	0.622													28	45					1.42536e-11	1.5024e-11	1	1	0	A	149916917	C	A	149916917	3	1	40	1	0	0	0	0	1	0	0	0	11365	796	28	5	1164	5	OTUD7B	1	149916917	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	1322373	149916917	99333704	5	3793										
CR1	1378	broad.mit.edu	37	chr1	207751246	207751246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	atcagtggtgacctaccgctGcaatcttggaagcagaggga	13	9	2	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:207751246G>A	ENST00000367049.4	+	29	4634	c.4634G>A	c.(4633-4635)tGc>tAc	p.C1545Y	CR1_ENST00000367052.1_Missense_Mutation_p.C1095Y|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Missense_Mutation_p.C1095Y|CR1_ENST00000367053.1_Missense_Mutation_p.C1095Y|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000400960.2_Missense_Mutation_p.C1095Y	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1095	Sushi 24.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACCTACCGCTGCAATCTTGGA	0.522													8	223					0	0	1	0	0	A	207751246	G	A	207751246	3	1	40	1	0	0	0	0	1	0	0	0	3863	1319	46	3	4748	3	CR1	1	207751246	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	57834329	207751246	41499375	6	3794										
ITPKB	3707	broad.mit.edu	37	chr1	226827357	226827357	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cggttcacggtgccgtcttcTttctgagaaagagaacaccc	10	12	4	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:226827357T>C	ENST00000429204.1	-	6	2781	c.2454A>G	c.(2452-2454)aaA>aaG	p.K818K	ITPKB_ENST00000272117.3_Silent_p.K818K	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	818							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TGCCGTCTTCTTTCTGAGAAA	0.567													18	37					0	0	1	0	0	C	226827357	T	C	226827357	2	2	40	1	0	0	0	0	0	0	0	1	7961	1606	56	4		4	ITPKB	1	226827357	Silent	SNP	T	TCGA-NA-A4QW-01A-11D-A28R-08	19076111	226827357	22423264	7	3795										
OR2G6	391211	broad.mit.edu	37	chr1	248685017	248685017	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tttcagatcagcctcagctaGagaggtttctttttgccatc	8	10	4	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:248685017G>A	ENST00000343414.4	+	1	102	c.70G>A	c.(70-72)Gag>Aag	p.E24K		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTCAGCTAGAGAGGTTTCT	0.463													53	45					0	0	1	0	0	A	248685017	G	A	248685017	3	1	40	1	0	0	0	0	1	0	0	0	11047	943	33	3	72	3	OR2G6	1	248685017	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	21857660	248685017	565604	8	3796										
DPP10	57628	broad.mit.edu	37	chr2	116572463	116572463	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ataatgtcattgtagcaagaTttgatggcagaggaagtgga	13	3	1	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr2:116572463T>A	ENST00000410059.1	+	20	2275	c.1795T>A	c.(1795-1797)Ttt>Att	p.F599I	DPP10_ENST00000393147.2_Missense_Mutation_p.F603I|DPP10_ENST00000310323.8_Missense_Mutation_p.F592I|DPP10_ENST00000409163.1_Missense_Mutation_p.F549I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	599					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity	p.F592I(1)|p.F599I(1)		breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TGTAGCAAGATTTGATGGCAG	0.423													33	117					0	0	1	0	0	A	116572463	T	A	116572463	3	1	40	1	0	0	0	0	1	0	0	0	4753	1493	52	4	2044	4	DPP10	2	116572463	Missense_Mutation	SNP	T	TCGA-NA-A4QW-01A-11D-A28R-08		116572463	126626910	9	3797										
SPHKAP	80309	broad.mit.edu	37	chr2	228860403	228860403	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tggtacatctctggtatcaaGgctgtcactgtagagggcaa	12	8	3	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr2:228860403G>A	ENST00000392056.3	-	8	4502	c.4456C>T	c.(4456-4458)Ctt>Ttt	p.L1486F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L1486F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1486						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGGTATCAAGGCTGTCACTG	0.532													7	46					0	0	1	0	0	A	228860403	G	A	228860403	3	1	40	1	0	0	0	0	1	0	0	0	15103	1000	35	3	666	3	SPHKAP	2	228860403	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	112287940	228860403	14338970	10	3798										
ZNF654	55279	broad.mit.edu	37	chr3	88189976	88189976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	catacgtcagaccattgcctCccagttaccttgatgaacgg	8	13	1	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr3:88189976C>T	ENST00000309495.5	+	1	1723	c.1516C>T	c.(1516-1518)Ccc>Tcc	p.P506S	CGGBP1_ENST00000462901.1_Intron	NM_018293.2	NP_060763.2	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(3)	12		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		ACCATTGCCTCCCAGTTACCT	0.393													14	58					0	0	1	0	0	T	88189976	C	T	88189976	3	4	40	1	0	0	0	0	1	0	0	0	18123	855	30	3	1518	3	ZNF654	3	88189976	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		88189976	109832454	11	3799										
NCK1	4690	broad.mit.edu	37	chr3	136664877	136664877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ttgaaaaacctgaaaatgacCcagagtggtggaaatgcagg	12	6	0	4			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr3:136664877C>T	ENST00000469404.1	+	2	578	c.487C>T	c.(487-489)Cca>Tca	p.P163S	NCK1_ENST00000288986.2_Missense_Mutation_p.P227S|NCK1_ENST00000481752.1_Missense_Mutation_p.P227S	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	227	SH3 2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						TGAAAATGACCCAGAGTGGTG	0.378													47	47					0	0	1	0	0	T	136664877	C	T	136664877	3	4	40	1	0	0	0	0	1	0	0	0	10265	623	22	3	685	3	NCK1	3	136664877	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	48474901	136664877	61357553	12	3800										
TRIML2	205860	broad.mit.edu	37	chr4	189022258	189022258	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	agctcggtggcaagcttgatCgcttgattcagaagggtttc	13	8	1	3	rs141580546	by1000genomes	TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr4:189022258C>T	ENST00000512729.1	-	3	656	c.282G>A	c.(280-282)gcG>gcA	p.A94A	TRIML2_ENST00000536972.1_Silent_p.A144A|TRIML2_ENST00000326754.3_Silent_p.A94A	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	94							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CAAGCTTGATCGCTTGATTCA	0.433													10	3					0	0	1	0	0	T	189022258	C	T	189022258	2	4	40	1	0	0	0	0	0	0	0	1	16611	871	31	1		1	TRIML2	4	189022258	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		189022258	2132018	13	3801										
CDH9	1007	broad.mit.edu	37	chr5	26881650	26881650	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tcatcgttgtaggtcacaatGttgtcccggacatcgtcttt	9	10	3	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:26881650G>A	ENST00000231021.4	-	12	2137	c.1965C>T	c.(1963-1965)aaC>aaT	p.N655N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	655					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						AGGTCACAATGTTGTCCCGGA	0.413													31	93					0	0	1	0	0	A	26881650	G	A	26881650	2	1	40	1	0	0	0	0	0	0	0	1	3139	1368	48	3		3	CDH9	5	26881650	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		26881650	154033610	14	3802										
ZFR	51663	broad.mit.edu	37	chr5	32407014	32407015	+	In_Frame_Ins	INS	-	-	GCA													0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tccctgtccaggcagctgttINSgcagcagcagcagcagctgc							TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:32407014_32407015insGCA	ENST00000265069.8	-	6	998_999	c.896_897insTGC	c.(895-897)gac>gTGCac	p.299_299D>VH		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	299	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		AGGCAgctgttgcagcagcagc	0.48													8	53	---	---	---	---						GCA	32407015	-	GCA	32407014	7	5	40	1	0	1	1	0	0	0	0	0	17716	1799	63	0	2387	0	ZFR	5	32407014	In_Frame_Ins	INS	-	TCGA-NA-A4QW-01A-11D-A28R-08	5525364	32407014	148508246	15	3803										
MCC	4163	broad.mit.edu	37	chr5	112364641	112364641	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	agatttttacctgttggcccGctttagatcattcacgaact	7	10	2	2	rs145982424		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:112364641G>A	ENST00000302475.4	-	16	2862	c.2299C>T	c.(2299-2301)Cgg>Tgg	p.R767W	MCC_ENST00000515367.2_Missense_Mutation_p.R704W|MCC_ENST00000408903.3_Missense_Mutation_p.R957W|MCC_ENST00000514701.3_5'UTR	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	767					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTGTTGGCCCGCTTTAGATCA	0.537													12	175					0	0	1	0	0	A	112364641	G	A	112364641	3	1	40	1	0	0	0	0	1	0	0	0	9422	1086	38	1	198	1	MCC	5	112364641	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	79957627	112364641	68550619	16	3804										
PCDHGA11	0	broad.mit.edu	37	chr5	140801920	140801920	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ttctaaatgtgcaagatcaaGattctggagaaaatggtcaa	9	5	4	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:140801920G>A	ENST00000398587.2	+	1	1159	c.1126G>A	c.(1126-1128)Gat>Aat	p.D376N	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.D376N|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGATCAAGATTCTGGAGA	0.348													5	37					0	0	1	0	0	A	140801920	G	A	140801920	3	1	40	1	0	0	0	0	1	0	0	0	11598	942	33	3	1128	3	PCDHGA11	5	140801920	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	28437279	140801920	40113340	17	3805										
DUSP22	56940	broad.mit.edu	37	chr6	350858	350858	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gaagttctgggcctttctcaGaagactgtaatgtacctgaa	10	8	2	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:350858G>C	ENST00000344450.5	+	8	988	c.545G>C	c.(544-546)aGa>aCa	p.R182T	DUSP22_ENST00000604971.1_3'UTR|DUSP22_ENST00000419235.2_3'UTR	NM_020185.3	NP_064570.1	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	182					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GCCTTTCTCAGAAGACTGTAA	0.393													11	37					0	0	1	0	0	C	350858	G	C	350858	3	2	40	1	0	0	0	0	1	0	0	0	4847	942	33	2	575	2	DUSP22	6	350858	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		350858	170764209	18	3806										
HIST1H2BF	8343	broad.mit.edu	37	chr6	26200068	26200068	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tccaccatcacctccagggaGatccagacggccgtacgcct	9	17	1	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:26200068G>A	ENST00000359985.1	+	1	321	c.282G>A	c.(280-282)gaG>gaA	p.E94E		NM_003522.3	NP_003513.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	94					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(7)|upper_aerodigestive_tract(3)	17		all_hematologic(11;0.196)				CCTCCAGGGAGATCCAGACGG	0.602													69	120					0	0	1	0	0	A	26200068	G	A	26200068	2	1	40	1	0	0	0	0	0	0	0	1	7185	933	33	3		3	HIST1H2BF	6	26200068	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	25849210	26200068	144914999	19	3807										
HLA-B	3106	broad.mit.edu	37	chr6	31322991	31322991	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cgatggggacggtggactggGaagacggctctgggaaagga	20	6	1	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:31322991G>A	ENST00000412585.2	-	5	933	c.905C>T	c.(904-906)tCc>tTc	p.S302F		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						GGTGGACTGGGAAGACGGCTC	0.597									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				22	51					0	0	1	0	0	A	31322991	G	A	31322991	3	1	40	1	0	0	0	0	1	0	0	0	7236	1174	41	3	195	3	HLA-B	6	31322991	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	5122923	31322991	139792076	20	3808										
DOPEY1	23033	broad.mit.edu	37	chr6	83855292	83855292	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tttattagtggaattggttcGttcaatcagtgtcatgagag	11	4	3	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:83855292G>A	ENST00000349129.2	+	25	5851	c.5591G>A	c.(5590-5592)cGt>cAt	p.R1864H	DOPEY1_ENST00000484282.1_3'UTR|DOPEY1_ENST00000237163.5_Missense_Mutation_p.R1845H|DOPEY1_ENST00000369739.3_Missense_Mutation_p.R1855H	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1864					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GAATTGGTTCGTTCAATCAGT	0.373													7	12					0	0	1	0	0	A	83855292	G	A	83855292	3	1	40	1	0	0	0	0	1	0	0	0	4734	1145	40	1	5681	1	DOPEY1	6	83855292	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	52532301	83855292	87259775	21	3809										
NUP43	348995	broad.mit.edu	37	chr6	150067548	150067548	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cctgtagcgaacgtctccgcGgtctgtaaacttcccggagg	12	13	2	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:150067548G>A	ENST00000340413.2	-	1	160	c.84C>T	c.(82-84)acC>acT	p.T28T	NUP43_ENST00000367403.3_Silent_p.T89T|NUP43_ENST00000367404.4_Silent_p.T28T|NUP43_ENST00000463048.3_Intron|NUP43_ENST00000460354.2_Silent_p.T28T	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	28					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		ACGTCTCCGCGGTCTGTAAAC	0.587											OREG0017720	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	94	130					0	0	1	0	0	A	150067548	G	A	150067548	2	1	40	1	0	0	0	0	0	0	0	1	10812	1103	39	1		1	NUP43	6	150067548	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	66212256	150067548	21047519	22	3810										
TNRC18	84629	broad.mit.edu	37	chr7	5352339	5352339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gtgtgggctgcggaggaggcGcctggggctggggcgcgggc	25	9	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr7:5352339G>A	ENST00000399537.4	-	27	8531	c.8183C>T	c.(8182-8184)gCg>gTg	p.A2728V	TNRC18_ENST00000430969.1_Missense_Mutation_p.A2728V			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2728							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGGAGGAGGCGCCTGGGGCTG	0.736													6	15					0	0	1	0	0	A	5352339	G	A	5352339	3	1	40	1	0	0	0	0	1	0	0	0	16398	1087	38	1	739	1	TNRC18	7	5352339	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		5352339	153786324	23	3811										
IGF2BP3	10643	broad.mit.edu	37	chr7	23391160	23391160	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tcagggatataggctactttCaaggtgaaattctctaactg	9	7	3	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr7:23391160C>T	ENST00000258729.3	-	6	803	c.447G>A	c.(445-447)ttG>ttA	p.L149L	IGF2BP3_ENST00000491719.1_5'UTR	NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	149	RRM 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						AGGCTACTTTCAAGGTGAAAT	0.527													19	43					0	0	1	0	0	T	23391160	C	T	23391160	2	4	40	1	0	0	0	0	0	0	0	1	7618	825	29	3		3	IGF2BP3	7	23391160	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	18038821	23391160	135747503	24	3812										
SUMF2	25870	broad.mit.edu	37	chr7	56140699	56140699	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tgtctttatagggattttgtCagggagaaaaagtatcggac	12	4	2	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr7:56140699C>G	ENST00000434526.2	+	3	322	c.291C>G	c.(289-291)gtC>gtG	p.V97V	SUMF2_ENST00000437307.2_Silent_p.V78V|SUMF2_ENST00000275607.9_5'UTR|SUMF2_ENST00000413756.1_Silent_p.V78V|SUMF2_ENST00000342190.6_Silent_p.V97V|SUMF2_ENST00000395436.2_Silent_p.V97V|SUMF2_ENST00000395435.2_Silent_p.V97V	NM_001042469.1|NM_015411.2	NP_001035934.2|NP_056226.2	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2	78						endoplasmic reticulum lumen	metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	14	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGGATTTTGTCAGGGAGAAAA	0.478													10	25					0	0	1	0	0	G	56140699	C	G	56140699	2	3	40	1	0	0	0	0	0	0	0	1	15441	813	29	2		2	SUMF2	7	56140699	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	32749539	56140699	102997964	25	3813										
AGPAT6	137964	broad.mit.edu	37	chr8	41467297	41467297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tgacattttctacttttgccGgaaaggaatggagaccatta	9	7	1	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr8:41467297G>A	ENST00000396987.3	+	4	1286	c.359G>A	c.(358-360)cGg>cAg	p.R120Q	RP11-360L9.8_ENST00000581909.1_RNA	NM_178819.3	NP_848934.1	Q86UL3	GPAT4_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 6	120					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			TACTTTTGCCGGAAAGGAATG	0.443													121	50					0	0	1	0	0	A	41467297	G	A	41467297	3	1	40	1	0	0	0	0	1	0	0	0	388	1116	39	1	369	1	AGPAT6	8	41467297	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		41467297	104896725	26	3814										
FAM135B	51059	broad.mit.edu	37	chr8	139151238	139151238	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	aaaccactgacctgttttttGgcttagttggtagaggaaac	10	7	0	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr8:139151238G>T	ENST00000395297.1	-	18	4062	c.3892C>A	c.(3892-3894)Caa>Aaa	p.Q1298K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1298										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCTGTTTTTTGGCTTAGTTGG	0.438										HNSCC(54;0.14)			16	22					5.01169e-05	5.07678e-05	1	1	0	T	139151238	G	T	139151238	3	4	40	1	0	0	0	0	1	0	0	0	5480	1357	47	5	340	5	FAM135B	8	139151238	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	97683941	139151238	7212784	27	3815										
EPPK1	83481	broad.mit.edu	37	chr8	144940732	144940732	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ggctggtccttggcgggcacCaggacgcccgcgatgcagct	16	14	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr8:144940732C>T	ENST00000525985.1	-	2	6761	c.6690G>A	c.(6688-6690)ctG>ctA	p.L2230L				P58107	EPIPL_HUMAN	epiplakin 1	2230						cytoplasm|cytoskeleton	protein binding|structural molecule activity	p.L2230L(1)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCGGGCACCAGGACGCCCG	0.687													6	151					0	0	1	0	0	T	144940732	C	T	144940732	2	4	40	1	0	0	0	0	0	0	0	1	5218	581	21	3		3	EPPK1	8	144940732	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	5789494	144940732	1423290	28	3816										
DENND4C	55667	broad.mit.edu	37	chr9	19316786	19316786	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	catatctcagaccaatcacaGaggctccttcaaataaagcc	5	13	3	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:19316786G>A	ENST00000380432.2	+	8	1081	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	DENND4C_ENST00000307015.9_5'UTR|DENND4C_ENST00000434457.2_Missense_Mutation_p.E586K|DENND4C_ENST00000602925.1_Missense_Mutation_p.E586K	NM_017925.4	NP_060395.5	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	350	dDENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						ACCAATCACAGAGGCTCCTTC	0.373													44	15					0	0	1	0	0	A	19316786	G	A	19316786	3	1	40	1	0	0	0	0	1	0	0	0	4463	943	33	3	1078	3	DENND4C	9	19316786	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		19316786	121896645	29	3817										
CNTNAP3	79937	broad.mit.edu	37	chr9	39133037	39133037	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ccccgcgcccgctgcgtacgCgaaggacacagccgagcgcg	14	18	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:39133037C>G	ENST00000297668.6	-	13	2045	c.1972G>C	c.(1972-1974)Gcg>Ccg	p.A658P	CNTNAP3_ENST00000377659.1_Missense_Mutation_p.A657P|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.A564P|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.A570P|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.A657P	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	658	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GCTGCGTACGCGAAGGACACA	0.776													3	6					0	0	1	0	0	G	39133037	C	G	39133037	3	3	40	1	0	0	0	0	1	0	0	0	3671	768	27	5	1942	5	CNTNAP3	9	39133037	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	19816251	39133037	102080394	30	3818										
ZCCHC6	79670	broad.mit.edu	37	chr9	88937264	88937264	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	acactggatacagacttgatCtaagatatttaaaaacttgg	7	6	1	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:88937264C>A	ENST00000277141.6	-	15	3295	c.871G>T	c.(871-873)Gat>Tat	p.D291Y	ZCCHC6_ENST00000375963.3_Missense_Mutation_p.D1002Y|ZCCHC6_ENST00000375960.2_Intron|ZCCHC6_ENST00000375961.2_Missense_Mutation_p.D1002Y			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1002					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						CAGACTTGATCTAAGATATTT	0.343													18	8					3.51602e-12	3.75684e-12	1	1	0	A	88937264	C	A	88937264	3	1	40	1	0	0	0	0	1	0	0	0	17649	913	32	2	1539	2	ZCCHC6	9	88937264	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	49804227	88937264	52276167	31	3819										
TEX10	54881	broad.mit.edu	37	chr9	103109336	103109336	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tcttaagcaatatgctgctaCggccagtaattagagctggg	11	8	1	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:103109336C>T	ENST00000374902.4	-	3	709	c.533G>A	c.(532-534)cGt>cAt	p.R178H	TEX10_ENST00000535814.1_Missense_Mutation_p.R181H|TEX10_ENST00000537512.1_Missense_Mutation_p.R113H	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	178						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TATGCTGCTACGGCCAGTAAT	0.413													18	9					0	0	1	0	0	T	103109336	C	T	103109336	3	4	40	1	0	0	0	0	1	0	0	0	15830	536	19	1	2308	1	TEX10	9	103109336	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	14172072	103109336	38104095	32	3820										
CCBL1	883	broad.mit.edu	37	chr9	131600040	131600040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	atttgccggccagctccatgGggtccagctgccagttgctg	13	13	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:131600040G>A	ENST00000436267.2	-	8	922	c.773C>T	c.(772-774)cCc>cTc	p.P258L	CCBL1_ENST00000483599.1_5'UTR|CCBL1_ENST00000320665.6_Missense_Mutation_p.P114L|CCBL1_ENST00000302586.3_Missense_Mutation_p.P164L			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	164					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CAGCTCCATGGGGTCCAGCTG	0.597													46	6					0	0	1	0	0	A	131600040	G	A	131600040	3	1	40	1	0	0	0	0	1	0	0	0	2750	1232	43	3	809	3	CCBL1	9	131600040	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	28490704	131600040	9613391	33	3821										
SLC16A12	387700	broad.mit.edu	37	chr10	91198855	91198855	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	atgccacttcctgacatggcGataccataagcaagggcttt	9	11	0	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:91198855G>A	ENST00000341233.4	-	6	834	c.444C>T	c.(442-444)atC>atT	p.I148I	SLC16A12_ENST00000371790.4_Silent_p.I178I	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	148						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						CTGACATGGCGATACCATAAG	0.498													20	140					0	0	1	0	0	A	91198855	G	A	91198855	2	1	40	1	0	0	0	0	0	0	0	1	14459	1048	37	1		1	SLC16A12	10	91198855	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		91198855	44335892	34	3822										
CRTAC1	55118	broad.mit.edu	37	chr10	99696031	99696031	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tcccctgccggtcccgcagcGcgtagtagggtgagctgcgc	15	15	0	1	rs80014629	byFrequency	TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:99696031G>A	ENST00000370597.3	-	3	672	c.317C>T	c.(316-318)gCg>gTg	p.A106V	CRTAC1_ENST00000370591.2_Missense_Mutation_p.A106V|CRTAC1_ENST00000298819.4_Missense_Mutation_p.A106V	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	106						proteinaceous extracellular matrix	calcium ion binding	p.A106V(1)		autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GTCCCGCAGCGCGTAGTAGGG	0.617													28	44					0	0	1	0	0	A	99696031	G	A	99696031	3	1	40	1	0	0	0	0	1	0	0	0	3919	1087	38	1	1720	1	CRTAC1	10	99696031	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	8497176	99696031	35838716	35	3823										
ARCN1	372	broad.mit.edu	37	chr11	118454048	118454050	+	In_Frame_Del	DEL	AGA	AGA	-													0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	agaaatggattctcatgaggAgaaggtgttcagagccgtca							TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr11:118454048_118454050delAGA	ENST00000359415.4	+	4	710_712	c.545_547delAGA	c.(544-549)gag>g	p.EK182del	ARCN1_ENST00000392859.3_In_Frame_Del_p.EK53del|ARCN1_ENST00000264028.4_In_Frame_Del_p.EK141del|ARCN1_ENST00000534182.2_Intron			P48444	COPD_HUMAN	archain 1	141					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol				endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|urinary_tract(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TCTCATGAGGAGAAGGTGTTCAG	0.404													17	25	---	---	---	---						-	118454050	AGA	-	118454048	7	5	40	1	0	1	0	1	0	0	0	0	839	304	11	0	432	0	ARCN1	11	118454048	In_Frame_Del	DEL	AGA	TCGA-NA-A4QW-01A-11D-A28R-08		118454048	16552468	36	3824										
B4GALNT3	283358	broad.mit.edu	37	chr12	644395	644395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gaacattccagctgtggatcCacacctccagttctaccatc	6	15	1	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr12:644395C>T	ENST00000266383.5	+	2	246	c.233C>T	c.(232-234)cCa>cTa	p.P78L		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	78						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GCTGTGGATCCACACCTCCAG	0.597													6	29					0	0	1	0	0	T	644395	C	T	644395	3	4	40	1	0	0	0	0	1	0	0	0	1266	594	21	3	239	3	B4GALNT3	12	644395	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		644395	133207500	37	3825										
MTMR6	9107	broad.mit.edu	37	chr13	25848322	25848322	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gtcaagtaattttacttgttCgacctaaaagaaaaaaagat	6	5	1	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr13:25848322C>T	ENST00000381801.5	-	2	789	c.28G>A	c.(28-30)Gaa>Aaa	p.E10K	MTMR6_ENST00000540661.1_Missense_Mutation_p.E10K	NM_004685.3	NP_004676.3	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	10						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TTTACTTGTTCGACCTAAAAG	0.313													22	8					0	0	1	0	0	T	25848322	C	T	25848322	3	4	40	1	0	0	0	0	1	0	0	0	9994	893	31	1	1889	1	MTMR6	13	25848322	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		25848322	89321556	38	3826										
MYCBP2	23077	broad.mit.edu	37	chr13	77792029	77792029	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	attaaaagtactgccgtatgGttgctgcctgcagtgacttg	11	8	0	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr13:77792029G>C	ENST00000407578.2	-	21	3269	c.3003C>G	c.(3001-3003)aaC>aaG	p.N1001K	MYCBP2_ENST00000357337.6_Missense_Mutation_p.N963K|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Missense_Mutation_p.N963K	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	963					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGCCGTATGGTTGCTGCCTG	0.378													25	85					0	0	1	0	0	C	77792029	G	C	77792029	3	2	40	1	0	0	0	0	1	0	0	0	10065	1252	44	5	11285	5	MYCBP2	13	77792029	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	51943707	77792029	37377849	39	3827										
SLC10A2	6555	broad.mit.edu	37	chr13	103710664	103710664	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cagagtcgacccacattttgGtatagataaggaggcacagc	11	9	0	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr13:103710664G>A	ENST00000245312.3	-	2	1042	c.446C>T	c.(445-447)aCc>aTc	p.T149I		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	149					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CCACATTTTGGTATAGATAAG	0.483													13	75					0	0	1	0	0	A	103710664	G	A	103710664	3	1	40	1	0	0	0	0	1	0	0	0	14428	1261	44	3	620	3	SLC10A2	13	103710664	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	25918635	103710664	11459214	40	3828										
OR4K14	122740	broad.mit.edu	37	chr14	20483158	20483158	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	atgtccaggaaagctaggttCcccagcaggaagtacatagg	12	9	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr14:20483158C>T	ENST00000305045.2	-	1	194	c.195G>A	c.(193-195)ggG>ggA	p.G65G		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AAGCTAGGTTCCCCAGCAGGA	0.483													15	59					0	0	1	0	0	T	20483158	C	T	20483158	2	4	40	1	0	0	0	0	0	0	0	1	11116	842	30	3		3	OR4K14	14	20483158	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		20483158	86866382	41	3829										
TTLL5	23093	broad.mit.edu	37	chr14	76232491	76232491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cattagataatgaagatgaaGaacaggaggcttcccaggag	12	6	0	5			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr14:76232491G>A	ENST00000298832.9	+	20	2000	c.1795G>A	c.(1795-1797)Gaa>Aaa	p.E599K	TTLL5_ENST00000555422.1_3'UTR|TTLL5_ENST00000554510.1_Missense_Mutation_p.E108K|TTLL5_ENST00000557636.1_Missense_Mutation_p.E613K|TTLL5_ENST00000556893.1_Missense_Mutation_p.E150K	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	599					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGAAGATGAAGAACAGGAGGC	0.403													12	19					0	0	1	0	0	A	76232491	G	A	76232491	3	1	40	1	0	0	0	0	1	0	0	0	16791	943	33	3	1869	3	TTLL5	14	76232491	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	55749333	76232491	31117049	42	3830										
DYNC1H1	1778	broad.mit.edu	37	chr14	102506745	102506745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ttgcaaaggttcaggcagacGaggtgattgttctcttgaat	12	6	2	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr14:102506745G>A	ENST00000360184.4	+	63	12027	c.11863G>A	c.(11863-11865)Gag>Aag	p.E3955K	RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3955					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TCAGGCAGACGAGGTGATTGT	0.512													20	33					0	0	1	0	0	A	102506745	G	A	102506745	3	1	40	1	0	0	0	0	1	0	0	0	4867	1059	37	1	12113	1	DYNC1H1	14	102506745	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	26274254	102506745	4842795	43	3831										
TLN2	83660	broad.mit.edu	37	chr15	62942335	62942335	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gacccgaggaaagggatttgGctggaagcgggcagaacact	16	8	0	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr15:62942335G>T	ENST00000561311.1	+	4	419	c.189G>T	c.(187-189)tgG>tgT	p.W63C	TLN2_ENST00000306829.6_Missense_Mutation_p.W63C			Q9Y4G6	TLN2_HUMAN	talin 2	63					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AAGGGATTTGGCTGGAAGCGG	0.478													40	6					1.30998e-17	1.43914e-17	1	1	0	T	62942335	G	T	62942335	3	4	40	1	0	0	0	0	1	0	0	0	16007	1212	42	5	195	5	TLN2	15	62942335	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		62942335	39589057	44	3832										
MAN2C1	4123	broad.mit.edu	37	chr15	75653473	75653473	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cccccatccccaaagccaaaGaggaaggcactgtggttggc	11	14	0	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr15:75653473G>C	ENST00000565683.1	-	12	1385	c.1374C>G	c.(1372-1374)ctC>ctG	p.L458L	MAN2C1_ENST00000563622.1_Silent_p.L359L|MAN2C1_ENST00000267978.5_Silent_p.L458L|MAN2C1_ENST00000569482.1_Silent_p.L458L	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	458					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CAAAGCCAAAGAGGAAGGCAC	0.647													12	3					0	0	1	0	0	C	75653473	G	C	75653473	2	2	40	1	0	0	0	0	0	0	0	1	9267	929	33	2		2	MAN2C1	15	75653473	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	12711138	75653473	26877919	45	3833										
RPL3L	6123	broad.mit.edu	37	chr16	1995899	1995899	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cccttcagcatgacgaagtcGttgttcacttccccgtagtg	9	13	2	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr16:1995899G>A	ENST00000268661.7	-	8	1078	c.984C>T	c.(982-984)aaC>aaT	p.N328N		NM_005061.2	NP_005052.1	Q92901	RL3L_HUMAN	ribosomal protein L3-like	328					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						TGACGAAGTCGTTGTTCACTT	0.612													22	43					0	0	1	0	0	A	1995899	G	A	1995899	2	1	40	1	0	0	0	0	0	0	0	1	13645	1136	40	1		1	RPL3L	16	1995899	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		1995899	88358854	46	3834										
POLR2A	5430	broad.mit.edu	37	chr17	7414885	7414885	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ccccgtacgcaccacgtccaAtgacattgtggagatcttca	8	14	2	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:7414885A>G	ENST00000322644.6	+	24	4478	c.4079A>G	c.(4078-4080)aAt>aGt	p.N1360S		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1360					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ACCACGTCCAATGACATTGTG	0.592													15	3					0	0	1	0	0	G	7414885	A	G	7414885	3	3	40	1	0	0	0	0	1	0	0	0	12261	101	4	4	4173	4	POLR2A	17	7414885	Missense_Mutation	SNP	A	TCGA-NA-A4QW-01A-11D-A28R-08		7414885	73780325	47	3835										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	6					0	0	1	0	0	T	7577538	C	T	7577538	3	4	40	1	0	0	0	0	1	0	0	0	16441	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	162653	7577538	73617672	48	3836										
XYLT2	64132	broad.mit.edu	37	chr17	48431783	48431783	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tctcagggaagatgagccccGgcatccagtgggatgagagc	15	10	1	3	rs148860176	byFrequency	TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:48431783G>A	ENST00000017003.2	+	3	692	c.643G>A	c.(643-645)Ggc>Agc	p.G215S	XYLT2_ENST00000507602.1_Missense_Mutation_p.G215S	NM_022167.2	NP_071450.2	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	215					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(2)|urinary_tract(1)	12	Breast(11;7.18e-19)					GATGAGCCCCGGCATCCAGTG	0.667													33	17					0	0	1	0	0	A	48431783	G	A	48431783	3	1	40	1	0	0	0	0	1	0	0	0	17523	1116	39	1	653	1	XYLT2	17	48431783	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	40854245	48431783	32763427	49	3837										
PPM1E	22843	broad.mit.edu	37	chr17	57057477	57057477	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gaggcagtgaaagttgtgtcCgaccacctgaaagagaataa	12	7	0	3	rs140315231		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:57057477C>T	ENST00000308249.2	+	7	1482	c.1353C>T	c.(1351-1353)tcC>tcT	p.S451S		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	460	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			AAGTTGTGTCCGACCACCTGA	0.502													13	40					0	0	1	0	0	T	57057477	C	T	57057477	2	4	40	1	0	0	0	0	0	0	0	1	12386	639	23	1		1	PPM1E	17	57057477	Silent	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	8625694	57057477	24137733	50	3838										
FAM20A	54757	broad.mit.edu	37	chr17	66538939	66538955	+	Splice_Site	DEL	AAGTCCAGAATCCTGCA	AAGTCCAGAATCCTGCA	-													0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ctgttggcggcacccgtcggAagtccagaatcctgcaagag							TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:66538939_66538955delAAGTCCAGAATCCTGCA	ENST00000592554.1	-	6	1535_1546	c.812_splice	c.e6-1	p.R273_splice	PRKAR1A_ENST00000588188.2_Intron|FAM20A_ENST00000226094.5_5'UTR	NM_001243746.1|NM_017565.3	NP_001230675.1|NP_060035.2	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	273						extracellular region				cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(1)	9	Breast(10;1.64e-13)					CACCCGTCGGAAGTCCAGAATCCTGCAAGAGAGGAAG	0.521													30	45	---	---	---	---						-	66538955	AAGTCCAGAATCCTGCA	-	66538939	8	5	40	1	0	1	0	1	0	0	1	0	5568	246	9	0	825	0	FAM20A	17	66538939	Splice_Site	DEL	AAGTCCAGAATCCTGCA	TCGA-NA-A4QW-01A-11D-A28R-08	9481462	66538939	14656271	51	3839										
DCXR	51181	broad.mit.edu	37	chr17	79994778	79994778	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ctccaggaagggctgcagcaGggcgacagcggcgttgttca	16	11	1	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:79994778G>A	ENST00000306869.2	-	3	311	c.262C>T	c.(262-264)Ctg>Ttg	p.L88L	DCXR_ENST00000584318.1_Intron	NM_001195218.1|NM_016286.3	NP_001182147.1|NP_057370.1	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	88					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity			kidney(1)|lung(3)	4	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGCTGCAGCAGGGCGACAGCG	0.687													17	14					0	0	1	0	0	A	79994778	G	A	79994778	2	1	40	1	0	0	0	0	0	0	0	1	4342	991	35	3		3	DCXR	17	79994778	Silent	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	13455839	79994778	1200432	52	3840										
SERPINB10	5273	broad.mit.edu	37	chr18	61585320	61585320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tgcgatatatggagagaaaaCgtatgcatttcacaatgtaa	9	5	1	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr18:61585320C>T	ENST00000238508.3	+	4	415	c.356C>T	c.(355-357)aCg>aTg	p.T119M		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10									p.T119M(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				GGAGAGAAAACGTATGCATTT	0.348													14	5					0	0	1	0	0	T	61585320	C	T	61585320	3	4	40	1	0	0	0	0	1	0	0	0	14150	536	19	1	366	1	SERPINB10	18	61585320	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		61585320	16491928	53	3841										
DHPS	1725	broad.mit.edu	37	chr19	12792434	12792434	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	gcttggaagccggtggtgccGaaggcctccagcagtgcgcg	17	12	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:12792434G>C	ENST00000210060.7	-	1	282	c.147C>G	c.(145-147)ttC>ttG	p.F49L	DHPS_ENST00000351660.5_Missense_Mutation_p.F49L	NM_001930.3	NP_001921.1	P49366	DHYS_HUMAN	deoxyhypusine synthase	49					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8					Sulfadoxine(DB01299)	CGGTGGTGCCGAAGGCCTCCA	0.632													44	8					0	0	1	0	0	C	12792434	G	C	12792434	3	2	40	1	0	0	0	0	1	0	0	0	4513	1049	37	2	998	2	DHPS	19	12792434	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		12792434	46336549	54	3842										
OR7A5	26659	broad.mit.edu	37	chr19	14938184	14938184	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	atgtctttattcctcagactAtagataaaggggttcagcat	8	7	3	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:14938184A>G	ENST00000322301.3	-	2	957	c.870T>C	c.(868-870)taT>taC	p.Y290Y	OR7A5_ENST00000601611.1_Intron|OR7A5_ENST00000594432.1_Silent_p.Y290Y			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y290Y(2)		breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						TCCTCAGACTATAGATAAAGG	0.478													4	91					0	0	1	0	0	G	14938184	A	G	14938184	2	3	40	1	0	0	0	0	0	0	0	1	11262	456	16	4		4	OR7A5	19	14938184	Silent	SNP	A	TCGA-NA-A4QW-01A-11D-A28R-08	2145750	14938184	44190799	55	3843										
ATP4A	495	broad.mit.edu	37	chr19	36051399	36051399	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ccaccttgcagccctgggccGccaggatgcggatgtcggcg	15	15	0	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:36051399G>A	ENST00000262623.3	-	6	681	c.653C>T	c.(652-654)gCg>gTg	p.A218V		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	218					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding	p.A218V(1)		breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GCCCTGGGCCGCCAGGATGCG	0.637													57	100					0	0	1	0	0	A	36051399	G	A	36051399	3	1	40	1	0	0	0	0	1	0	0	0	1144	1087	38	1	2522	1	ATP4A	19	36051399	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	21113215	36051399	23077584	56	3844										
ZFP14	57677	broad.mit.edu	37	chr19	36832073	36832073	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ctcaccggtgtgaagtttgtGatgtcgaataagatgtgcac	12	7	1	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:36832073G>A	ENST00000270001.7	-	5	770	c.655C>T	c.(655-657)Cac>Tac	p.H219Y		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TGAAGTTTGTGATGTCGAATA	0.443													30	144					0	0	1	0	0	A	36832073	G	A	36832073	3	1	40	1	0	0	0	0	1	0	0	0	17696	1290	45	3	950	3	ZFP14	19	36832073	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	780674	36832073	22296910	57	3845										
ZNF781	163115	broad.mit.edu	37	chr19	38160916	38160916	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tatgttgggtaaggtgggcaCgctttctaaagggctttcca	13	7	1	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:38160916C>T	ENST00000358582.4	-	4	882	c.134G>A	c.(133-135)cGt>cAt	p.R45H	ZNF781_ENST00000590008.1_Missense_Mutation_p.R45H|ZFP30_ENST00000586732.1_Intron	NM_152605.3	NP_689818.2	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						AAGGTGGGCACGCTTTCTAAA	0.383													127	98					0	0	1	0	0	T	38160916	C	T	38160916	3	4	40	1	0	0	0	0	1	0	0	0	18202	536	19	1	853	1	ZNF781	19	38160916	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	1328843	38160916	20968067	58	3846										
CKM	1158	broad.mit.edu	37	chr19	45811690	45811690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ctgcagccctacgcagaagcGgcggaaaacctccttcatgt	10	14	1	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:45811690G>A	ENST00000221476.3	-	6	928	c.754C>T	c.(754-756)Cgc>Tgc	p.R252C		NM_001824.4	NP_001815.2	P06732	KCRM_HUMAN	creatine kinase, muscle	252	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(3)|prostate(2)|skin(2)	17		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	ACGCAGAAGCGGCGGAAAACC	0.597													11	46					0	0	1	0	0	A	45811690	G	A	45811690	3	1	40	1	0	0	0	0	1	0	0	0	3471	1116	39	1	403	1	CKM	19	45811690	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	7650774	45811690	13317293	59	3847										
NOSIP	0	broad.mit.edu	37	chr19	50062164	50062164	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tccccatcaccttcatctgcCgggcaatctccttcttctgg	6	17	6	0			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:50062164C>T	ENST00000391853.3	-	5	399	c.248G>A	c.(247-249)cGg>cAg	p.R83Q	NOSIP_ENST00000596358.1_Missense_Mutation_p.R83Q|NOSIP_ENST00000339093.3_Missense_Mutation_p.R83Q	NM_015953.3	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	83					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		CTTCATCTGCCGGGCAATCTC	0.562													15	428					0	0	1	0	0	T	50062164	C	T	50062164	3	4	40	1	0	0	0	0	1	0	0	0	10591	652	23	1	681	1	NOSIP	19	50062164	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08	4250474	50062164	9066819	60	3848										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715983	52715983	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	tgacacccccatggtgcggcGggccgcagcctccaagctgg	14	16	0	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:52715983G>A	ENST00000322088.6	+	5	606	c.548G>A	c.(547-549)cGg>cAg	p.R183Q	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.R128Q|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.R4Q	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	183	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183Q(10)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ATGGTGCGGCGGGCCGCAGCC	0.617			Mis		clear cell ovarian carcinoma								91	12					0	0	1	0	0	A	52715983	G	A	52715983	3	1	40	1	0	0	0	0	1	0	0	0	12430	1116	39	1	566	1	PPP2R1A	19	52715983	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	2653819	52715983	6413000	61	3849										
TGM6	343641	broad.mit.edu	37	chr20	2411210	2411210	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ggagagaagcttctggtggaGaaggacattactctagagga	15	5	2	3			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr20:2411210G>T	ENST00000202625.2	+	11	1858	c.1797G>T	c.(1795-1797)gaG>gaT	p.E599D	TGM6_ENST00000381423.1_Missense_Mutation_p.E599D	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	599					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	TTCTGGTGGAGAAGGACATTA	0.502													24	23					6.36457e-07	6.53206e-07	1	1	0	T	2411210	G	T	2411210	3	4	40	1	0	0	0	0	1	0	0	0	15893	933	33	2	1839	2	TGM6	20	2411210	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08		2411210	60614310	62	3850										
ATRN	8455	broad.mit.edu	37	chr20	3614997	3614997	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	ctggtggctgctgtggtttgGaagatcaaacaaagttgttg	14	5	1	1			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr20:3614997G>C	ENST00000262919.5	+	26	3971	c.3903G>C	c.(3901-3903)tgG>tgC	p.W1301C		NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	1301					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTGGTTTGGAAGATCAAAC	0.458													11	66					0	0	1	0	0	C	3614997	G	C	3614997	3	2	40	1	0	0	0	0	1	0	0	0	1204	1183	41	2	4027	2	ATRN	20	3614997	Missense_Mutation	SNP	G	TCGA-NA-A4QW-01A-11D-A28R-08	1203787	3614997	59410523	63	3851										
DIP2A	23181	broad.mit.edu	37	chr21	47961709	47961709	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	cacctccaagaaaagcagtcCtgtcgatgaacggtctaagt	9	11	1	2			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr21:47961709C>A	ENST00000318711.7	+	18	2263	c.2080C>A	c.(2080-2082)Ctg>Atg	p.L694M	DIP2A_ENST00000427143.2_Missense_Mutation_p.L629M|DIP2A_ENST00000417564.2_Missense_Mutation_p.L693M|DIP2A_ENST00000400274.1_Missense_Mutation_p.L689M|DIP2A_ENST00000457905.3_Missense_Mutation_p.L693M|DIP2A_ENST00000435722.3_Missense_Mutation_p.L693M|DIP2A_ENST00000466639.1_Missense_Mutation_p.L650M	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	693					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		AAAAGCAGTCCTGTCGATGAA	0.488													19	31					1.56452e-12	1.6949e-12	1	1	0	A	47961709	C	A	47961709	3	1	40	1	0	0	0	0	1	0	0	0	4555	680	24	5	2147	5	DIP2A	21	47961709	Missense_Mutation	SNP	C	TCGA-NA-A4QW-01A-11D-A28R-08		47961709	168186	64	3852										
TXN2	25828	broad.mit.edu	37	chr22	36872876	36872876	+	Frame_Shift_Del	DEL	C	C	-													0.169230769230769	11	0.695576666179527	1.6253562877665	3.62011173184358	1.23613571331244	0.428307982231794	1	0	accatcttctctaacctcggCcccaggatcttgcagggtcc							TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr22:36872876delC	ENST00000216185.2	-	3	757	c.291delG	c.(289-291)ggfs	p.G97fs	TXN2_ENST00000416967.1_5'UTR|TXN2_ENST00000403313.1_Frame_Shift_Del_p.G97fs|TXN2_ENST00000487725.1_5'UTR			Q99757	THIOM_HUMAN	thioredoxin 2	97	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity			breast(1)|lung(1)|prostate(1)	3						CTAACCTCGGCCCCAGGATCT	0.547													57	147	---	---	---	---						-	36872876	C	-	36872876	7	5	40	1	0	1	0	1	0	0	0	0	16852	726	26	0	217	0	TXN2	22	36872876	Frame_Shift_Del	DEL	C	TCGA-NA-A4QW-01A-11D-A28R-08		36872876	14431690	65	3853										
FUCA1	2517	broad.mit.edu	37	chr1	24186288	24186288	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	gaagtcatataatcacatacCttgacagggctgtcattgta	8	8	3	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr1:24186288C>T	ENST00000374479.3	-	4	775	c.768_splice	c.e4+1	p.K256_splice		NM_000147.4	NP_000138.2	P04066	FUCO_HUMAN	fucosidase, alpha-L- 1, tissue	256					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		AATCACATACCTTGACAGGGC	0.413													8	27					0	0	1	0	0	T	24186288	C	T	24186288	5	4	41	1	0	0	0	0	0	0	1	0	6128	695	24	3	652	3	FUCA1	1	24186288	Splice_Site	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		24186288	225064333	1	3854										
C2orf16	84226	broad.mit.edu	37	chr2	27799908	27799908	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tttcaataccaatttatcacGccacagaatcttcagaaatg	4	10	4	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr2:27799908G>A	ENST00000408964.2	+	1	520	c.469G>A	c.(469-471)Gcc>Acc	p.A157T		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	157										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AATTTATCACGCCACAGAATC	0.403													14	63					0	0	1	0	0	A	27799908	G	A	27799908	3	1	41	1	0	0	0	0	1	0	0	0	2171	1087	38	1	471	1	C2orf16	2	27799908	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08		27799908	215399465	2	3855										
TTN	7273	broad.mit.edu	37	chr2	179478877	179478877	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	agatgtactctttattggggAttaatttggtggccttgaag	12	4	1	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr2:179478877A>T	ENST00000589042.1	-	262	49471	c.49247T>A	c.(49246-49248)aTc>aAc	p.I16416N	TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.I13848N|TTN_ENST00000342175.6_Missense_Mutation_p.I7543N|TTN_ENST00000591111.1_Missense_Mutation_p.I14775N|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.I7476N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I7351N|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14775	Ig-like 100.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTATTGGGGATTAATTTGGT	0.433													8	8					0	0	1	0	0	T	179478877	A	T	179478877	3	4	41	1	0	0	0	0	1	0	0	0	16796	333	12	4	58850	4	TTN	2	179478877	Missense_Mutation	SNP	A	TCGA-NA-A4QX-01A-11D-A28R-08	151678969	179478877	63720496	3	3856										
TSEN2	80746	broad.mit.edu	37	chr3	12531437	12531437	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttccgtgctgaaatgattaaCaacaatgtgattgtgaggaa	10	5	0	4			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr3:12531437C>T	ENST00000444864.1	+	2	525	c.138C>T	c.(136-138)aaC>aaT	p.N46N	TSEN2_ENST00000415684.1_Silent_p.N46N|TSEN2_ENST00000402228.3_Silent_p.N46N|TSEN2_ENST00000314571.7_Silent_p.N46N|TSEN2_ENST00000284995.6_Silent_p.N46N|TSEN2_ENST00000454502.2_Silent_p.N46N|TSEN2_ENST00000383797.5_Silent_p.N46N	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	46					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						AAATGATTAACAACAATGTGA	0.443													39	52					0	0	1	0	0	T	12531437	C	T	12531437	2	4	41	1	0	0	0	0	0	0	0	1	16672	477	17	3		3	TSEN2	3	12531437	Silent	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		12531437	185490993	4	3857										
SCN10A	6336	broad.mit.edu	37	chr3	38738892	38738892	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tggcttcatcttcattttgtAttgagctagatgtcctcatg	8	8	4	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr3:38738892A>G	ENST00000449082.2	-	27	5818	c.5819T>C	c.(5818-5820)aTa>aCa	p.I1940T		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1940					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTCATTTTGTATTGAGCTAGA	0.478													24	64					0	0	1	0	0	G	38738892	A	G	38738892	3	3	41	1	0	0	0	0	1	0	0	0	13965	449	16	4	55	4	SCN10A	3	38738892	Missense_Mutation	SNP	A	TCGA-NA-A4QX-01A-11D-A28R-08	26207455	38738892	159283538	5	3858										
TIGIT	201633	broad.mit.edu	37	chr3	114014628	114014628	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tcaccctccagtcgctgaccGtgaacgatacaggggagtac	11	13	1	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr3:114014628G>A	ENST00000481065.1	+	3	3114	c.499G>A	c.(499-501)Gtg>Atg	p.V167M	TIGIT_ENST00000383671.3_Missense_Mutation_p.V100M|TIGIT_ENST00000486257.1_Missense_Mutation_p.V100M			Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	100					negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(1)	17						GTCGCTGACCGTGAACGATAC	0.567													42	49					0	0	1	0	0	A	114014628	G	A	114014628	3	1	41	1	0	0	0	0	1	0	0	0	15961	1145	40	1	304	1	TIGIT	3	114014628	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	75275736	114014628	84007802	6	3859										
COL6A6	131873	broad.mit.edu	37	chr3	130284093	130284093	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttctccccgaactgggaaggCctatactggagctgccatca	10	13	2	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr3:130284093C>T	ENST00000358511.6	+	3	948	c.917C>T	c.(916-918)gCc>gTc	p.A306V	COL6A6_ENST00000453409.2_Missense_Mutation_p.A306V	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	306	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen		p.A306D(1)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ACTGGGAAGGCCTATACTGGA	0.478													49	69					0	0	1	0	0	T	130284093	C	T	130284093	3	4	41	1	0	0	0	0	1	0	0	0	3726	739	26	3	927	3	COL6A6	3	130284093	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08	16269465	130284093	67738337	7	3860										
FBXW7	0	broad.mit.edu	37	chr4	153247288	153247288	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tgccatcatattgaacacagCggactgctgcaacatgaccc	8	13	1	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr4:153247288C>A	ENST00000281708.4	-	10	2743	c.1514G>T	c.(1513-1515)cGc>cTc	p.R505L	FBXW7_ENST00000603548.1_Missense_Mutation_p.R505L|FBXW7_ENST00000603841.1_Missense_Mutation_p.R505L|FBXW7_ENST00000393956.3_Missense_Mutation_p.R329L|FBXW7_ENST00000263981.5_Missense_Mutation_p.R425L|FBXW7_ENST00000296555.5_Missense_Mutation_p.R387L	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	505			R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R505L(7)|p.R505H(5)|p.R266L(1)|p.R266H(1)|p.?(1)|p.R505P(1)|p.R425H(1)|p.R425L(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TTGAACACAGCGGACTGCTGC	0.468			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								17	47					4.14922e-12	4.55402e-12	1	1	0	A	153247288	C	A	153247288	3	1	41	1	0	0	0	0	1	0	0	0	5801	768	27	5	621	5	FBXW7	4	153247288	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		153247288	37906988	8	3861										
SLC1A3	6507	broad.mit.edu	37	chr5	36686177	36686177	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ctgcctgcagggatcgcctcCggaccaccaccaacgtactg	10	17	0	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr5:36686177C>T	ENST00000265113.4	+	10	1911	c.1435C>T	c.(1435-1437)Cgg>Tgg	p.R479W	SLC1A3_ENST00000381918.3_Missense_Mutation_p.R434W|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	479					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	GGATCGCCTCCGGACCACCAC	0.552													30	85					0	0	1	0	0	T	36686177	C	T	36686177	3	4	41	1	0	0	0	0	1	0	0	0	14487	643	23	1	1486	1	SLC1A3	5	36686177	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		36686177	144229083	9	3862										
PIK3R1	5295	broad.mit.edu	37	chr5	67589579	67589596	+	In_Frame_Del	DEL	AAATTACATGAATATAAC	AAATTACATGAATATAAC	-													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	atattgaagctgtagggaaaAaattacatgaatataacact					rs17852841		TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr5:67589579_67589596delAAATTACATGAATATAAC	ENST00000521381.1	+	11	1958_1975	c.1342_1359delAAATTACATGAATATAAC	c.(1342-1359)del	p.KLHEYN448del	PIK3R1_ENST00000523872.1_In_Frame_Del_p.KLHEYN85del|PIK3R1_ENST00000521657.1_In_Frame_Del_p.KLHEYN448del|PIK3R1_ENST00000336483.5_In_Frame_Del_p.KLHEYN178del|PIK3R1_ENST00000396611.1_In_Frame_Del_p.KLHEYN448del|PIK3R1_ENST00000274335.5_In_Frame_Del_p.KLHEYN448del|PIK3R1_ENST00000320694.8_In_Frame_Del_p.KLHEYN148del	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	448					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.N453_T454insN(3)|p.H450_E451del(2)|p.L449fs*3(1)|p.Y152N(1)|p.T454_D464del(1)|p.Y452_Q455>SGGSRIK(1)|p.L449S(1)|p.?(1)|p.G446_Y452>VI(1)|p.Y452N(1)|p.T454_Q455>Q(1)|p.E451_Y452del(1)|p.E451_Y452delEY(1)|p.K448_L449>I(1)|p.Y182N(1)|p.453_454insN(1)|p.0?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TGTAGGGAAAAAATTACATGAATATAACACTCAGTTTC	0.266			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			8	25	---	---	---	---						-	67589596	AAATTACATGAATATAAC	-	67589579	7	5	41	1	0	1	0	1	0	0	0	0	11965	15	1	0	1510	0	PIK3R1	5	67589579	In_Frame_Del	DEL	AAATTACATGAATATAAC	TCGA-NA-A4QX-01A-11D-A28R-08	30903402	67589579	113325681	10	3863										
PCDHB10	0	broad.mit.edu	37	chr5	140573707	140573707	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	acgaggccctgcaggctttcGagttccgcgtgggcgccaca	14	14	0	0	rs17844576		TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr5:140573707G>T	ENST00000239446.4	+	1	1766	c.1582G>T	c.(1582-1584)Gag>Tag	p.E528*		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		528	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGCTTTCGAGTTCCGCGT	0.692													21	328					1.55795e-14	1.75269e-14	1	1	0	T	140573707	G	T	140573707	4	4	41	1	0	0	0	0	0	1	0	0	11581	1059	37	2	1584	2	PCDHB10	5	140573707	Nonsense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	72984128	140573707	40341553	11	3864										
PCDHB11	0	broad.mit.edu	37	chr5	140580929	140580929	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	acgaggccctgcaggctttcGacttccgcgtgggcgccaca	13	15	0	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr5:140580929G>T	ENST00000354757.3	+	1	1582	c.1582G>T	c.(1582-1584)Gac>Tac	p.D528Y	PCDHB11_ENST00000536699.1_Missense_Mutation_p.D163Y	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		528	Cadherin 5.		D -> E (in dbSNP:rs799834).		calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGCTTTCGACTTCCGCGT	0.677													6	198					1.12685e-05	1.17926e-05	1	1	0	T	140580929	G	T	140580929	3	4	41	1	0	0	0	0	1	0	0	0	11582	1058	37	2	1584	2	PCDHB11	5	140580929	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	7222	140580929	40334331	12	3865										
NEDD9	4739	broad.mit.edu	37	chr6	11201242	11201242	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tggtttgtttagaggctctcActaagaaataggacacttgc	10	7	1	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr6:11201242A>T	ENST00000379433.5	-	3	639	c.497T>A	c.(496-498)gTg>gAg	p.V166E	NEDD9_ENST00000379446.5_Intron|NEDD9_ENST00000504387.1_Intron|RP3-510L9.1_ENST00000500636.2_RNA	NM_182966.3	NP_892011.2	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	0	Interacts strongly with spindle- regulatory protein D1M1.				actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			AGAGGCTCTCACTAAGAAATA	0.428													4	102					0	0	1	0	0	T	11201242	A	T	11201242	3	4	41	1	0	0	0	0	1	0	0	0	10359	159	6	4	2097	4	NEDD9	6	11201242	Missense_Mutation	SNP	A	TCGA-NA-A4QX-01A-11D-A28R-08		11201242	159913825	13	3866										
FTSJ2	29960	broad.mit.edu	37	chr7	2274828	2274828	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	cacttctgatgactctttccTgctggcttcaggtttgatga	9	10	3	4			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr7:2274828T>C	ENST00000242257.8	-	3	698	c.670A>G	c.(670-672)Agg>Ggg	p.R224G	FTSJ2_ENST00000440306.2_3'UTR|FTSJ2_ENST00000407040.1_Missense_Mutation_p.R130G|FTSJ2_ENST00000486040.1_5'UTR	NM_013393.1	NP_037525.1	Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	224					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		GACTCTTTCCTGCTGGCTTCA	0.468													34	63					0	0	1	0	0	C	2274828	T	C	2274828	3	2	41	1	0	0	0	0	1	0	0	0	6122	1579	55	4	74	4	FTSJ2	7	2274828	Missense_Mutation	SNP	T	TCGA-NA-A4QX-01A-11D-A28R-08		2274828	156863835	14	3867										
FAM188B	84182	broad.mit.edu	37	chr7	30921881	30921881	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	catcctctttagcctgcagcCggggctcctgcgtgactgga	12	14	1	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr7:30921881C>T	ENST00000265299.6	+	16	2134	c.2057C>T	c.(2056-2058)cCg>cTg	p.P686L	INMT-FAM188B_ENST00000458257.1_3'UTR|AQP1_ENST00000509504.1_Missense_Mutation_p.P149L|AQP1_ENST00000434909.2_Missense_Mutation_p.P32L	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	686										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCCTGCAGCCGGGGCTCCTG	0.592													33	40					0	0	1	0	0	T	30921881	C	T	30921881	3	4	41	1	0	0	0	0	1	0	0	0	5545	652	23	1	2119	1	FAM188B	7	30921881	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08	28647053	30921881	128216782	15	3868										
NCF1	653361	broad.mit.edu	37	chr7	74197924	74197924	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ggatcccagcgtccttcctcGagcccctggacagtcctgac	10	17	0	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr7:74197924G>C	ENST00000289473.4	+	7	701	c.631G>C	c.(631-633)Gag>Cag	p.E211Q	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	211	Asp/Glu-rich (highly acidic).|SH3 1.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						GTCCTTCCTCGAGCCCCTGGA	0.637													15	55					0	0	1	0	0	C	74197924	G	C	74197924	3	2	41	1	0	0	0	0	1	0	0	0	10262	1059	37	2	657	2	NCF1	7	74197924	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	43276043	74197924	84940739	16	3869										
SLC25A13	10165	broad.mit.edu	37	chr7	95775911	95775911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ggtcccgcacgacagacagaGcactgactcgaggaccagtg	13	13	0	3			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr7:95775911G>A	ENST00000416240.2	-	14	1602	c.1412C>T	c.(1411-1413)gCt>gTt	p.A471V	SLC25A13_ENST00000542654.1_Missense_Mutation_p.A362V|SLC25A13_ENST00000265631.5_Missense_Mutation_p.A470V	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	470					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GACAGACAGAGCACTGACTCG	0.433													73	129					0	0	1	0	0	A	95775911	G	A	95775911	3	1	41	1	0	0	0	0	1	0	0	0	14529	971	34	3	638	3	SLC25A13	7	95775911	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	21577987	95775911	63362752	17	3870										
OCM2	4951	broad.mit.edu	37	chr7	97617777	97617777	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ctggtcgttgtctatgaaccGgaaaacatccttcacctgac	8	12	2	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr7:97617777G>A	ENST00000257627.4	-	2	236	c.145C>T	c.(145-147)Cgg>Tgg	p.R49W	OCM2_ENST00000473987.2_5'UTR	NM_006188.3	NP_006179.2	P0CE71	OCM2_HUMAN	oncomodulin 2	49	EF-hand 1.						calcium ion binding			lung(4)	4						TCTATGAACCGGAAAACATCC	0.507													36	62					0	0	1	0	0	A	97617777	G	A	97617777	3	1	41	1	0	0	0	0	1	0	0	0	10869	1115	39	1	196	1	OCM2	7	97617777	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	1841866	97617777	61520886	18	3871										
HIATL1	84641	broad.mit.edu	37	chr9	97218544	97218544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tgatgtgggcagcagggaccGtggctgccatgtccagcatc	15	11	0	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr9:97218544G>A	ENST00000375344.3	+	10	1320	c.1051G>A	c.(1051-1053)Gtg>Atg	p.V351M	HIATL1_ENST00000428393.2_Intron	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	351					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				AGCAGGGACCGTGGCTGCCAT	0.562													29	25					0	0	1	0	0	A	97218544	G	A	97218544	3	1	41	1	0	0	0	0	1	0	0	0	7138	1145	40	1	1089	1	HIATL1	9	97218544	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08		97218544	43994887	19	3872										
CTBP2	1488	broad.mit.edu	37	chr10	126692042	126692042	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	cgggggtgcagggggccgttCatgatctgggggcggatacc	20	9	2	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr10:126692042C>T	ENST00000309035.6	-	2	1828	c.1698G>A	c.(1696-1698)atG>atA	p.M566I	CTBP2_ENST00000411419.2_Missense_Mutation_p.M26I|CTBP2_ENST00000337195.5_Missense_Mutation_p.M26I|CTBP2_ENST00000334808.6_Missense_Mutation_p.M94I|CTBP2_ENST00000531469.1_Missense_Mutation_p.M26I|CTBP2_ENST00000494626.2_Missense_Mutation_p.M26I	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	26					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GGGGGCCGTTCATGATCTGGG	0.687													9	14					0	0	1	0	0	T	126692042	C	T	126692042	3	4	41	1	0	0	0	0	1	0	0	0	4022	826	29	3	1291	3	CTBP2	10	126692042	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		126692042	8842705	20	3873										
HEATR5A	25938	broad.mit.edu	37	chr14	31817004	31817004	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	caaagtataaaggattccaaTacaagaatttaggtgttgag	9	4	0	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr14:31817004T>C	ENST00000543095.2	-	19	3002	c.2818A>G	c.(2818-2820)Att>Gtt	p.I940V	HEATR5A_ENST00000389961.3_Missense_Mutation_p.I934V|HEATR5A_ENST00000439348.1_Missense_Mutation_p.I934V|HEATR5A_ENST00000404677.3_Missense_Mutation_p.I940V|HEATR5A_ENST00000439727.1_Missense_Mutation_p.I647V	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	934							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AGGATTCCAATACAAGAATTT	0.428													10	7					0	0	1	0	0	C	31817004	T	C	31817004	3	2	41	1	0	0	0	0	1	0	0	0	7071	1406	49	4	3394	4	HEATR5A	14	31817004	Missense_Mutation	SNP	T	TCGA-NA-A4QX-01A-11D-A28R-08		31817004	75532536	21	3874										
CKMT1B	1159	broad.mit.edu	37	chr15	43891378	43891378	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	gagctggtgcaactggtcatCgatggagtaaactatttgat	12	6	1	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr15:43891378C>T	ENST00000300283.6	+	10	1553	c.1161C>T	c.(1159-1161)atC>atT	p.I387I	CKMT1B_ENST00000441322.1_Silent_p.I387I	NM_020990.3	NP_066270.1	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B	387	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			large_intestine(1)|lung(3)|skin(1)	5		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	AACTGGTCATCGATGGAGTAA	0.473													74	66					0	0	1	0	0	T	43891378	C	T	43891378	2	4	41	1	0	0	0	0	0	0	0	1	3473	874	31	1		1	CKMT1B	15	43891378	Silent	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		43891378	58640014	22	3875										
CHD2	1106	broad.mit.edu	37	chr15	93524635	93524635	+	Missense_Mutation	SNP	G	G	T													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tttgcggttggctgaaacgaGagagaatgaagtgtcaacaa							TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr15:93524635G>T	ENST00000394196.4	+	24	4082	c.3014G>T	c.(3013-3015)aGa>aTa	p.R1005I	CHD2_ENST00000557381.1_Missense_Mutation_p.R1005I	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1005	Glu-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GCTGAAACGAGAGAGAATGAA	0.373													3	10					1	1	1	1	0	T	93524635	G	T	93524635	3	4	41	1	0	0	0	0	1	0	0	0	3347	942	33	2	3108	2	CHD2	15	93524635	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	49633257	93524635	9006757	23	3876	16	2								
CHD2	1106	broad.mit.edu	37	chr15	93524636	93524636	+	Missense_Mutation	SNP	A	A	T													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttgcggttggctgaaacgagAgagaatgaagtgtcaacaag							TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr15:93524636A>T	ENST00000394196.4	+	24	4083	c.3015A>T	c.(3013-3015)agA>agT	p.R1005S	CHD2_ENST00000557381.1_Missense_Mutation_p.R1005S	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1005	Glu-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTGAAACGAGAGAGAATGAAG	0.368													3	11					0	0	1	0	0	T	93524636	A	T	93524636	3	4	41	1	0	0	0	0	1	0	0	0	3347	301	11	4	3109	4	CHD2	15	93524636	Missense_Mutation	SNP	A	TCGA-NA-A4QX-01A-11D-A28R-08	1	93524636	9006756	24	3877	16	2								
DNASE1	1773	broad.mit.edu	37	chr16	3707025	3707025	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	agggagtttgccattgttccCctgcatgcggccccggggga	15	12	0	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr16:3707025C>T	ENST00000246949.5	+	6	3671	c.462C>T	c.(460-462)ccC>ccT	p.P154P	DNASE1_ENST00000414110.2_Intron|DNASE1_ENST00000407479.1_Silent_p.P154P	NM_005223.3	NP_005214.2	P24855	DNAS1_HUMAN	deoxyribonuclease I	154			P -> A (in allele DNASE1*3; dbSNP:rs1799891).		apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity			lung(1)	1		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	CCATTGTTCCCCTGCATGCGG	0.602													6	33					0	0	1	0	0	T	3707025	C	T	3707025	2	4	41	1	0	0	0	0	0	0	0	1	4687	610	22	3		3	DNASE1	16	3707025	Silent	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		3707025	86647728	25	3878										
IGSF6	10261	broad.mit.edu	37	chr16	21658474	21658476	+	In_Frame_Del	DEL	CCT	CCT	-													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ctcttaccaccagtgtggtcCctcctcctgtctgtttagct							TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr16:21658474_21658476delCCT	ENST00000268389.4	-	2	466_468	c.405_407delAGG	c.(403-408)ggg>gg	p.GG135del	METTL9_ENST00000396014.4_Intron|METTL9_ENST00000358154.3_Intron	NM_005849.3	NP_005840.2	O95976	IGSF6_HUMAN	immunoglobulin superfamily, member 6	135					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(48;0.066)		CAGTGTGGTCCCTCCTCCTGTCT	0.468													36	77	---	---	---	---						-	21658476	CCT	-	21658474	7	5	41	1	0	1	0	1	0	0	0	0	7646	623	22	0	338	0	IGSF6	16	21658474	In_Frame_Del	DEL	CCT	TCGA-NA-A4QX-01A-11D-A28R-08	17951449	21658474	68696279	26	3879										
NFATC3	4775	broad.mit.edu	37	chr16	68200785	68200785	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttgaaactccgcaattcagaTatagaacttcgaaaaggaga	8	7	1	4			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr16:68200785T>C	ENST00000349223.5	+	5	1865	c.1641T>C	c.(1639-1641)gaT>gaC	p.D547D	NFATC3_ENST00000575270.1_Silent_p.D547D|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Silent_p.D547D|NFATC3_ENST00000329524.4_Silent_p.D547D	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	547	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GCAATTCAGATATAGAACTTC	0.333													13	20					0	0	1	0	0	C	68200785	T	C	68200785	2	2	41	1	0	0	0	0	0	0	0	1	10410	1403	49	4		4	NFATC3	16	68200785	Silent	SNP	T	TCGA-NA-A4QX-01A-11D-A28R-08	46542311	68200785	22153968	27	3880										
TP53	7157	broad.mit.edu	37	chr17	7578402	7578403	+	Frame_Shift_Ins	INS	-	-	T													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	agcagcgctcatggtgggggINScagcgcctcacaacctccgt							TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr17:7578402_7578403insT	ENST00000420246.2	-	5	659_660	c.527_528insA	c.(526-528)tccfs	p.S176fs	TP53_ENST00000445888.2_Frame_Shift_Ins_p.S176fs|TP53_ENST00000413465.2_Frame_Shift_Ins_p.S176fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.S176fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.S176fs|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000359597.4_Frame_Shift_Ins_p.S176fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	176	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|CP -> FS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(129)|p.C176Y(63)|p.C176*(12)|p.C176W(11)|p.C83F(9)|p.C44F(9)|p.C176S(8)|p.0?(8)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C44Y(3)|p.H178fs*69(3)|p.C83Y(3)|p.R175_E180delRCPHHE(3)|p.C83*(2)|p.V173fs*59(2)|p.C44*(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.P177fs*4(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*3(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGGTGGGGGCAGCGCCTCAC	0.649		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	10	---	---	---	---						T	7578403	-	T	7578402	7	5	41	1	0	1	1	0	0	0	0	0	16441	1195	42	0	770	0	TP53	17	7578402	Frame_Shift_Ins	INS	-	TCGA-NA-A4QX-01A-11D-A28R-08		7578402	73616808	28	3881										
MYO15A	51168	broad.mit.edu	37	chr17	18023599	18023599	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	gggaaggagaagctggaggtGcccctgccaccctctctgga	15	12	1	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr17:18023599G>A	ENST00000205890.5	+	2	1823	c.1485G>A	c.(1483-1485)gtG>gtA	p.V495V		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	495	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					AGCTGGAGGTGCCCCTGCCAC	0.642													34	8					0	0	1	0	0	A	18023599	G	A	18023599	2	1	41	1	0	0	0	0	0	0	0	1	10110	1306	46	3		3	MYO15A	17	18023599	Silent	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	10445197	18023599	63171611	29	3882										
CACNA1A	773	broad.mit.edu	37	chr19	13338336	13338336	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	acatgtccaggtaaggcatgCggcccctggcagcaccgaaa	12	13	0	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr19:13338336C>T	ENST00000360228.5	-	37	5533	c.5534G>A	c.(5533-5535)cGc>cAc	p.R1845H	CACNA1A_ENST00000573710.2_Intron	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1846					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GTAAGGCATGCGGCCCCTGGC	0.493													4	64					0	0	1	0	0	T	13338336	C	T	13338336	3	4	41	1	0	0	0	0	1	0	0	0	2556	768	27	1	2030	1	CACNA1A	19	13338336	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		13338336	45790647	30	3883										
ATP4A	495	broad.mit.edu	37	chr19	36054349	36054351	+	In_Frame_Del	DEL	CTT	CTT	-													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttgccacccccgccacccgcCttcttcttcttgctcatctt							TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr19:36054349_36054351delCTT	ENST00000262623.3	-	2	119_121	c.91_93delAAG	c.(91-93)del	p.K31del		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	31					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGCCACCCGCCTTCTTCTTCTTG	0.601													9	1171	---	---	---	---						-	36054351	CTT	-	36054349	7	5	41	1	0	1	0	1	0	0	0	0	1144	680	24	0	3098	0	ATP4A	19	36054349	In_Frame_Del	DEL	CTT	TCGA-NA-A4QX-01A-11D-A28R-08	22716013	36054349	23074634	31	3884										
ZNF573	126231	broad.mit.edu	37	chr19	38230644	38230644	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ctaaaggccctcccacactcCtgacattcatacggcttccc	5	18	1	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr19:38230644C>T	ENST00000339503.4	-	8	1074	c.573G>A	c.(571-573)caG>caA	p.Q191Q	ZNF573_ENST00000392138.1_Silent_p.Q162Q|ZNF573_ENST00000590414.2_Silent_p.Q249Q|ZNF573_ENST00000357309.3_Silent_p.Q161Q|ZNF573_ENST00000536220.1_Silent_p.Q161Q	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TCCCACACTCCTGACATTCAT	0.428													37	371					0	0	1	0	0	T	38230644	C	T	38230644	2	4	41	1	0	0	0	0	0	0	0	1	18061	680	24	3		3	ZNF573	19	38230644	Silent	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08	2176295	38230644	20898339	32	3885										
RASGRP4	115727	broad.mit.edu	37	chr19	38910572	38910572	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tcccccgtctccaagtggtcGaaaagcaaggacactttgcg	10	13	1	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr19:38910572G>T	ENST00000454404.2	-	6	804	c.591C>A	c.(589-591)ttC>ttA	p.F197L	RASGRP4_ENST00000587753.1_Missense_Mutation_p.F197L|RASGRP4_ENST00000426920.2_Missense_Mutation_p.F197L|RASGRP4_ENST00000293062.9_Missense_Mutation_p.F197L|RASGRP4_ENST00000433821.2_Missense_Mutation_p.F197L|RASGRP4_ENST00000587738.1_Missense_Mutation_p.F197L|RASGRP4_ENST00000586305.1_Missense_Mutation_p.F183L	NM_001146205.1|NM_170604.2	NP_001139677.1|NP_733749.1	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4	197					activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|prostate(3)|skin(1)	23	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCAAGTGGTCGAAAAGCAAGG	0.652													6	131					0.00116845	0.001195	1	1	0	T	38910572	G	T	38910572	3	4	41	1	0	0	0	0	1	0	0	0	13128	1049	37	2	1478	2	RASGRP4	19	38910572	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	679928	38910572	20218411	33	3886										
PPP2R1A	5518	broad.mit.edu	37	chr19	52716212	52716212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	cctctcctctccctaggactCggtgcggctgctggcggtgg	14	15	2	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr19:52716212C>T	ENST00000322088.6	+	6	714	c.656C>T	c.(655-657)tCg>tTg	p.S219L	PPP2R1A_ENST00000462990.1_Missense_Mutation_p.S40L|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S164L	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	219	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CCCTAGGACTCGGTGCGGCTG	0.647			Mis		clear cell ovarian carcinoma								130	38					0	0	1	0	0	T	52716212	C	T	52716212	3	4	41	1	0	0	0	0	1	0	0	0	12430	893	31	1	678	1	PPP2R1A	19	52716212	Missense_Mutation	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08	13805640	52716212	6412771	34	3887										
ZNF211	0	broad.mit.edu	37	chr19	58152473	58152476	+	Frame_Shift_Del	DEL	CAAA	CAAA	-													0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttctccatcaagacgccactCaaacaggggagaagccaaat							TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr19:58152473_58152476delCAAA	ENST00000544273.1	+	5	982_985	c.655_658delCAAA	c.(655-660)cafs	p.QT219fs	ZNF211_ENST00000299871.5_Frame_Shift_Del_p.QT272fs|ZNF211_ENST00000541801.1_Frame_Shift_Del_p.QT198fs|ZNF211_ENST00000347302.3_Frame_Shift_Del_p.QT207fs|ZNF211_ENST00000420680.1_Frame_Shift_Del_p.QT211fs|ZNF211_ENST00000391703.3_Frame_Shift_Del_p.QT146fs|ZNF211_ENST00000254182.7_Frame_Shift_Del_p.QT198fs|ZNF211_ENST00000240731.4_Frame_Shift_Del_p.QT220fs			Q13398	ZN211_HUMAN	zinc finger protein 211	207						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGACGCCACTCAAACAGGGGAGAA	0.471													22	42	---	---	---	---						-	58152476	CAAA	-	58152473	7	5	41	1	0	1	0	1	0	0	0	0	17824	827	29	0	672	0	ZNF211	19	58152473	Frame_Shift_Del	DEL	CAAA	TCGA-NA-A4QX-01A-11D-A28R-08	5436261	58152473	976510	35	3888										
SYNJ1	8867	broad.mit.edu	37	chr21	34053869	34053869	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ctgattgaatcaccattcacGgaccacattgaccgaaaaac	6	12	2	3			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chr21:34053869G>A	ENST00000382499.2	-	11	1406	c.1407C>T	c.(1405-1407)tcC>tcT	p.S469S	SYNJ1_ENST00000322229.7_Silent_p.S430S|SYNJ1_ENST00000433931.2_Silent_p.S469S|SYNJ1_ENST00000382491.3_Silent_p.S430S|SYNJ1_ENST00000357345.3_Silent_p.S430S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	430							inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding	p.S430S(1)		breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						CACCATTCACGGACCACATTG	0.398													22	60					0	0	1	0	0	A	34053869	G	A	34053869	2	1	41	1	0	0	0	0	0	0	0	1	15508	1103	39	1		1	SYNJ1	21	34053869	Silent	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08		34053869	14076026	36	3889										
SCML2	10389	broad.mit.edu	37	chrX	18338512	18338512	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	agtgtctttaagaggaacatCggccaggaggatgtattcat	12	6	2	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chrX:18338512C>A	ENST00000251900.4	-	6	585	c.426G>T	c.(424-426)ccG>ccT	p.P142P		NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	142					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					AGAGGAACATCGGCCAGGAGG	0.333													7	15					5.18039e-06	5.55042e-06	1	1	0	A	18338512	C	A	18338512	2	1	41	1	0	0	0	0	0	0	0	1	13963	871	31	2		2	SCML2	23	18338512	Silent	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08		18338512	136932048	37	3890										
SHROOM4	57477	broad.mit.edu	37	chrX	50351176	50351176	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	aaaagctagtcttggaatgaGccatttccctgcaaaacatc	7	10	1	1	rs149034742		TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chrX:50351176G>A	ENST00000376020.2	-	6	2991	c.2966C>T	c.(2965-2967)gCt>gTt	p.A989V	SHROOM4_ENST00000289292.7_Missense_Mutation_p.A989V|SHROOM4_ENST00000460112.3_Missense_Mutation_p.A873V	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	989					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CTTGGAATGAGCCATTTCCCT	0.408													10	13					0	0	1	0	0	A	50351176	G	A	50351176	3	1	41	1	0	0	0	0	1	0	0	0	14350	971	34	3	1531	3	SHROOM4	23	50351176	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	32012664	50351176	104919384	38	3891										
ZC3H12B	340554	broad.mit.edu	37	chrX	64719785	64719785	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttatgcctccagatgatccaTtaggacgccacggcccaagc	9	14	0	2			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chrX:64719785T>C	ENST00000338957.4	+	4	1073	c.1006T>C	c.(1006-1008)Tta>Cta	p.L336L	ZC3H12B_ENST00000423889.3_Silent_p.L325L	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	325							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGATGATCCATTAGGACGCCA	0.438													62	87					0	0	1	0	0	C	64719785	T	C	64719785	2	2	41	1	0	0	0	0	0	0	0	1	17620	1490	52	4		4	ZC3H12B	23	64719785	Silent	SNP	T	TCGA-NA-A4QX-01A-11D-A28R-08	14368609	64719785	90550775	39	3892										
IDH3G	3421	broad.mit.edu	37	chrX	153051890	153051890	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	ttattggcgatactcttgccGgtgttcctcgtagcctgggg	13	10	1	0			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chrX:153051890G>A	ENST00000370092.3	-	11	1124	c.939C>T	c.(937-939)acC>acT	p.T313T	IDH3G_ENST00000370093.1_Silent_p.T313T|IDH3G_ENST00000427365.2_Silent_p.T255T|IDH3G_ENST00000217901.5_Silent_p.T313T	NM_174869.2	NP_777358.1	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma	313					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|prostate(1)	17	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	TACTCTTGCCGGTGTTCCTCG	0.612													6	6					0	0	1	0	0	A	153051890	G	A	153051890	2	1	41	1	0	0	0	0	0	0	0	1	7541	1103	39	1		1	IDH3G	23	153051890	Silent	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	88332105	153051890	2218670	40	3893										
TAZ	6901	broad.mit.edu	37	chrX	153649045	153649045	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	tcagtgccctgcctgtactcGagcggctccgggcggagaac	14	14	1	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chrX:153649045G>C	ENST00000299328.5	+	10	1037	c.748G>C	c.(748-750)Gag>Cag	p.E250Q	TAZ_ENST00000351413.4_Missense_Mutation_p.E236Q|TAZ_ENST00000369790.4_Missense_Mutation_p.E206Q|TAZ_ENST00000350743.4_Missense_Mutation_p.E220Q|TAZ_ENST00000369776.4_Missense_Mutation_p.E220Q|TAZ_ENST00000498029.1_3'UTR	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin	250					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCTGTACTCGAGCGGCTCCG	0.647													20	81					0	0	1	0	0	C	153649045	G	C	153649045	3	2	41	1	0	0	0	0	1	0	0	0	15652	1059	37	2	786	2	TAZ	23	153649045	Missense_Mutation	SNP	G	TCGA-NA-A4QX-01A-11D-A28R-08	597155	153649045	1621515	41	3894										
SLC10A3	8273	broad.mit.edu	37	chrX	153716854	153716854	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.024390243902439	1	1	0.386306846576712	0	0.423097974822113	1	1	0	agctggatgtggagtggggcCagcccagccaggcctgagtg	18	10	0	1			TCGA-NA-A4QX-01A-11D-A28R-08	TCGA-NA-A4QX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3d2e39c3-47c6-4241-85b5-17f7793a3afe	f8a81e5f-712b-4863-b8c6-679ccccfb81f	g.chrX:153716854C>T	ENST00000263512.4	-	2	924	c.426G>A	c.(424-426)ctG>ctA	p.L142L	SLC10A3_ENST00000393587.4_Silent_p.L142L|SLC10A3_ENST00000393586.1_Silent_p.L197L|SLC10A3_ENST00000369649.4_Intron	NM_019848.3	NP_062822.1	P09131	P3_HUMAN	solute carrier family 10, member 3	142					organic anion transport	integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGAGTGGGGCCAGCCCAGCCA	0.612													43	70					0	0	1	0	0	T	153716854	C	T	153716854	2	4	41	1	0	0	0	0	0	0	0	1	14429	581	21	3		3	SLC10A3	23	153716854	Silent	SNP	C	TCGA-NA-A4QX-01A-11D-A28R-08	67809	153716854	1553706	42	3895										
MYOM3	127294	broad.mit.edu	37	chr1	24417411	24417411	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tagctctgaccttcgacgagGccttggattgggcaccgaca	12	12	1	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:24417411G>A	ENST00000330966.7	-	12	1473	c.1311C>T	c.(1309-1311)ggC>ggT	p.G437G	MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Silent_p.G436G|MYOM3_ENST00000374434.3_Silent_p.G436G			Q5VTT5	MYOM3_HUMAN	myomesin 3	436	Fibronectin type-III 1.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTTCGACGAGGCCTTGGATTG	0.637													58	96					0	0	1	0	0	A	24417411	G	A	24417411	2	1	42	1	0	0	0	0	0	0	0	1	10140	1190	42	3		3	MYOM3	1	24417411	Silent	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		24417411	224833210	1	3896										
ARID1A	8289	broad.mit.edu	37	chr1	27106580	27106580	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggaaaacaccttggttacacTcgccaacatctcggggcagt	10	12	1	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:27106580T>G	ENST00000324856.7	+	20	6562	c.6191T>G	c.(6190-6192)cTc>cGc	p.L2064R	ARID1A_ENST00000374152.2_Missense_Mutation_p.L1681R|ARID1A_ENST00000457599.2_Missense_Mutation_p.L1847R|ARID1A_ENST00000540690.1_Missense_Mutation_p.L392R	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2064					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TTGGTTACACTCGCCAACATC	0.557			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								86	104					0	0	1	0	0	G	27106580	T	G	27106580	3	3	42	1	0	0	0	0	1	0	0	0	910	1551	54	4	6269	4	ARID1A	1	27106580	Missense_Mutation	SNP	T	TCGA-NA-A4QY-01A-11D-A28R-08	2689169	27106580	222144041	2	3897										
IQCC	55721	broad.mit.edu	37	chr1	32671482	32671482	+	Frame_Shift_Del	DEL	G	G	-													0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	caaccgcgctgaggaaagctGggacccacggactccctgcc							TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:32671482delG	ENST00000537469.1	+	1	247	c.200delG	c.(199-201)tgfs	p.W67fs	IQCC_ENST00000291358.6_Intron|RP4-622L5.7_ENST00000373604.4_RNA|RP4-622L5.7_ENST00000421616.1_RNA	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	328										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GAGGAAAGCTGGGACCCACGG	0.657													2	4	---	---	---	---						-	32671482	G	-	32671482	7	5	42	1	0	1	0	1	0	0	0	0	7847	1357	47	0	202	0	IQCC	1	32671482	Frame_Shift_Del	DEL	G	TCGA-NA-A4QY-01A-11D-A28R-08	5564902	32671482	216579139	3	3898										
GRIK3	2899	broad.mit.edu	37	chr1	37291395	37291395	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gccttctctcgaacatgggtGatggtcaggggggccacggc	16	11	2	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:37291395G>C	ENST00000373091.3	-	11	1579	c.1563C>G	c.(1561-1563)atC>atG	p.I521M	GRIK3_ENST00000373093.4_Missense_Mutation_p.I521M	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	521					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GAACATGGGTGATGGTCAGGG	0.542													8	131					0	0	1	0	0	C	37291395	G	C	37291395	3	2	42	1	0	0	0	0	1	0	0	0	6815	1280	45	2	1220	2	GRIK3	1	37291395	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	4619913	37291395	211959226	4	3899										
HPCAL4	51440	broad.mit.edu	37	chr1	40148381	40148381	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gttcatgcgcatcatgatcaCggtgcccaccatcttgtaga	9	12	4	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:40148381C>T	ENST00000372844.3	-	4	794	c.403G>A	c.(403-405)Gtg>Atg	p.V135M		NM_016257.2	NP_057341.1	Q9UM19	HPCL4_HUMAN	hippocalcin like 4	135					central nervous system development	intracellular	calcium ion binding			breast(1)|central_nervous_system(1)|lung(5)|stomach(1)	8	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ATCATGATCACGGTGCCCACC	0.562													32	57					0	0	1	0	0	T	40148381	C	T	40148381	3	4	42	1	0	0	0	0	1	0	0	0	7371	536	19	1	176	1	HPCAL4	1	40148381	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	2856986	40148381	209102240	5	3900										
TRIM17	51127	broad.mit.edu	37	chr1	228595913	228595913	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggtctgtgtctatcctttcaCccacatggtcactgtggaga	10	11	4	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:228595913C>T	ENST00000366697.2	-	6	2379	c.1423G>A	c.(1423-1425)Gtg>Atg	p.V475M	TRIM17_ENST00000366698.2_Missense_Mutation_p.V475M|RP11-245P10.4_ENST00000436779.1_RNA|TRIM17_ENST00000295033.3_Missense_Mutation_p.V475M			Q9Y577	TRI17_HUMAN	tripartite motif containing 17	475	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				TATCCTTTCACCCACATGGTC	0.617													23	124					0	0	1	0	0	T	228595913	C	T	228595913	3	4	42	1	0	0	0	0	1	0	0	0	16553	507	18	3	14	3	TRIM17	1	228595913	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	188447532	228595913	20654708	6	3901										
URB2	9816	broad.mit.edu	37	chr1	229763491	229763492	+	Frame_Shift_Ins	INS	-	-	G													0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tttctcaccagtgctttcttINSccaaataaagaacaagtaag							TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr1:229763491_229763492insG	ENST00000258243.2	+	2	247_248	c.111_112insG	c.(109-114)ctcaaafs	p.K38fs		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	38						nucleolus		p.P38T(1)		breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						AGTGCTTTCTTCCAAATAAAGA	0.307													14	68	---	---	---	---						G	229763492	-	G	229763491	7	5	42	1	0	1	1	0	0	0	0	0	17084	1770	62	0	113	0	URB2	1	229763491	Frame_Shift_Ins	INS	-	TCGA-NA-A4QY-01A-11D-A28R-08	1167578	229763491	19487130	7	3902										
SMC6	79677	broad.mit.edu	37	chr2	17912350	17912350	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	aaattcaccaattacctggaTgttaaaatgatcaagaattg	6	6	2	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr2:17912350T>C	ENST00000448223.2	-	7	807	c.538A>G	c.(538-540)Atc>Gtc	p.I180V	SMC6_ENST00000402989.1_Missense_Mutation_p.I180V|SMC6_ENST00000351948.4_Missense_Mutation_p.I180V|SMC6_ENST00000381272.4_Missense_Mutation_p.I206V	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	180					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ATTACCTGGATGTTAAAATGA	0.343													3	39					0	0	1	0	0	C	17912350	T	C	17912350	3	2	42	1	0	0	0	0	1	0	0	0	14840	1464	51	4	2825	4	SMC6	2	17912350	Missense_Mutation	SNP	T	TCGA-NA-A4QY-01A-11D-A28R-08		17912350	225287023	8	3903										
NT5C1B	93034	broad.mit.edu	37	chr2	18765801	18765801	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggccaggggcgcgagcagctCgggttcttctcgtagaacga	16	11	2	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr2:18765801C>T	ENST00000304081.4	-	4	802	c.702G>A	c.(700-702)ccG>ccA	p.P234P	NT5C1B_ENST00000600945.1_Silent_p.P294P|NT5C1B-RDH14_ENST00000532967.1_Silent_p.P294P|NT5C1B_ENST00000359846.2_Silent_p.P294P	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GCGAGCAGCTCGGGTTCTTCT	0.687													13	14					0	0	1	0	0	T	18765801	C	T	18765801	2	4	42	1	0	0	0	0	0	0	0	1	10733	871	31	1		1	NT5C1B	2	18765801	Silent	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	853451	18765801	224433572	9	3904										
ARID5A	10865	broad.mit.edu	37	chr2	97215506	97215506	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ccagttaacctgtggaagatCtacaaagcagtggagaagct	11	8	1	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr2:97215506C>G	ENST00000454558.2	+	4	1249	c.72C>G	c.(70-72)atC>atG	p.I24M	ARID5A_ENST00000357485.3_Missense_Mutation_p.I92M			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	92					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						TGTGGAAGATCTACAAAGCAG	0.602													32	56					0	0	1	0	0	G	97215506	C	G	97215506	3	3	42	1	0	0	0	0	1	0	0	0	918	903	32	2	290	2	ARID5A	2	97215506	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	78449705	97215506	145983867	10	3905										
CCDC141	285025	broad.mit.edu	37	chr2	179737016	179737016	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	aggtacacttcatttttcacAtctaatatctcgttctcttt	3	10	5	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr2:179737016A>C	ENST00000420890.2	-	13	2040	c.1923T>G	c.(1921-1923)gaT>gaG	p.D641E	CCDC141_ENST00000295723.5_Missense_Mutation_p.D66E	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	66							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CATTTTTCACATCTAATATCT	0.368													14	31					0	0	1	0	0	C	179737016	A	C	179737016	3	2	42	1	0	0	0	0	1	0	0	0	2793	214	8	4	2473	4	CCDC141	2	179737016	Missense_Mutation	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08	82521510	179737016	63462357	11	3906										
CLASP2	23122	broad.mit.edu	37	chr3	33552148	33552148	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cattttgattgcagccagatTaattgggtagtctgcagttt	10	6	1	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr3:33552148T>A	ENST00000399362.4	-	37	4593	c.4240A>T	c.(4240-4242)Aat>Tat	p.N1414Y	CLASP2_ENST00000359576.5_Missense_Mutation_p.N1406Y|CLASP2_ENST00000307312.7_Missense_Mutation_p.N896Y|CLASP2_ENST00000461133.3_Missense_Mutation_p.N1174Y|CLASP2_ENST00000539981.1_3'UTR|CLASP2_ENST00000480013.1_Missense_Mutation_p.N1194Y|CLASP2_ENST00000468888.2_Missense_Mutation_p.N1415Y	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	1416										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						GCAGCCAGATTAATTGGGTAG	0.438													7	14					0	0	1	0	0	A	33552148	T	A	33552148	3	1	42	1	0	0	0	0	1	0	0	0	3478	1754	61	4	313	4	CLASP2	3	33552148	Missense_Mutation	SNP	T	TCGA-NA-A4QY-01A-11D-A28R-08		33552148	164470282	12	3907										
DHX30	22907	broad.mit.edu	37	chr3	47889849	47889849	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cttgagaacctggtgctgcaAgcgaaaatccacatgcctga	10	11	0	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr3:47889849A>G	ENST00000446256.2	+	16	2921	c.2349A>G	c.(2347-2349)caA>caG	p.Q783Q	DHX30_ENST00000445061.1_Silent_p.Q822Q|DHX30_ENST00000348968.4_Silent_p.Q794Q|DHX30_ENST00000457607.1_Silent_p.Q850Q	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	822	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TGGTGCTGCAAGCGAAAATCC	0.632													24	43					0	0	1	0	0	G	47889849	A	G	47889849	2	3	42	1	0	0	0	0	0	0	0	1	4532	69	3	4		4	DHX30	3	47889849	Silent	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08	14337701	47889849	150132581	13	3908										
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			266	32					0	0	1	0	0	G	178952085	A	G	178952085	3	3	42	1	0	0	0	0	1	0	0	0	11960	217	8	4	3218	4	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08	131062236	178952085	19070345	14	3909										
HTT	3064	broad.mit.edu	37	chr4	3225847	3225847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tcctgtcccttctctgtctcCggctactacaggtacctgag	8	15	2	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr4:3225847C>T	ENST00000355072.5	+	56	7899	c.7754C>T	c.(7753-7755)cCg>cTg	p.P2585L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2585					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TCTCTGTCTCCGGCTACTACA	0.512													42	135					0	0	1	0	0	T	3225847	C	T	3225847	3	4	42	1	0	0	0	0	1	0	0	0	7500	652	23	1	7976	1	HTT	4	3225847	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		3225847	187928429	15	3910										
EGFLAM	133584	broad.mit.edu	37	chr5	38451444	38451444	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggatcaagatcaaatgtgttCatgaggtttaaaacaactgc	9	6	3	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr5:38451444C>T	ENST00000322350.5	+	19	2917	c.2571C>T	c.(2569-2571)ttC>ttT	p.F857F	EGFLAM_ENST00000506135.1_5'UTR|EGFLAM_ENST00000354891.3_Silent_p.F865F|EGFLAM_ENST00000397202.2_Silent_p.F223F|EGFLAM_ENST00000514476.1_5'UTR|EGFLAM_ENST00000397210.3_5'UTR|EGFLAM_ENST00000336740.6_Silent_p.F623F	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	865	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CAAATGTGTTCATGAGGTTTA	0.468													46	111					0	0	1	0	0	T	38451444	C	T	38451444	2	4	42	1	0	0	0	0	0	0	0	1	4992	825	29	3		3	EGFLAM	5	38451444	Silent	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		38451444	142463816	16	3911										
GRM4	2914	broad.mit.edu	37	chr6	34101204	34101204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggaggaaggcatccaggggcCgtaaaggctgaggagcaggc	19	8	0	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr6:34101204C>T	ENST00000374181.3	-	1	239	c.70G>A	c.(70-72)Ggc>Agc	p.G24S	GRM4_ENST00000538487.1_Missense_Mutation_p.G24S|GRM4_ENST00000374177.3_Intron	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	24					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	ATCCAGGGGCCGTAAAGGCTG	0.612													27	22					0	0	1	0	0	T	34101204	C	T	34101204	3	4	42	1	0	0	0	0	1	0	0	0	6839	652	23	1	2708	1	GRM4	6	34101204	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		34101204	137013863	17	3912										
DST	667	broad.mit.edu	37	chr6	56391251	56391251	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gcgctcattgtcctcagctaCcattttctcaagtccttctc	5	15	4	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr6:56391251C>T	ENST00000370754.5	-	69	17943	c.17944G>A	c.(17944-17946)Gta>Ata	p.V5982I	DST_ENST00000370769.4_Missense_Mutation_p.V5804I|DST_ENST00000340834.4_5'UTR|DST_ENST00000370788.2_Missense_Mutation_p.V3607I|DST_ENST00000361203.3_Missense_Mutation_p.V5693I|DST_ENST00000421834.2_Missense_Mutation_p.V3716I|DST_ENST00000244364.6_Missense_Mutation_p.V3390I|DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Missense_Mutation_p.V5478I			Q03001	DYST_HUMAN	dystonin	5802					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCCTCAGCTACCATTTTCTCA	0.498													29	63					0	0	1	0	0	T	56391251	C	T	56391251	3	4	42	1	0	0	0	0	1	0	0	0	4809	507	18	3	5487	3	DST	6	56391251	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	22290047	56391251	114723816	18	3913										
SMAP1	60682	broad.mit.edu	37	chr6	71501409	71501409	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cagatttcctcctctgatgcTcctcttcagcctttggtatc	6	14	3	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr6:71501409T>A	ENST00000370455.3	+	5	680	c.432T>A	c.(430-432)gcT>gcA	p.A144A	SMAP1_ENST00000370452.3_Intron|SMAP1_ENST00000316999.5_Intron	NM_001044305.1	NP_001037770.1	Q8IYB5	SMAP1_HUMAN	small ArfGAP 1	144					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						CCTCTGATGCTCCTCTTCAGC	0.403													30	35					0	0	1	0	0	A	71501409	T	A	71501409	2	1	42	1	0	0	0	0	0	0	0	1	14819	1538	54	4		4	SMAP1	6	71501409	Silent	SNP	T	TCGA-NA-A4QY-01A-11D-A28R-08	15110158	71501409	99613658	19	3914										
INHBA	3624	broad.mit.edu	37	chr7	41729399	41729399	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	aggggctatggccccgcatgCggtagtggttgatgactgtt	16	8	0	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr7:41729399C>T	ENST00000242208.4	-	3	1376	c.1130G>A	c.(1129-1131)cGc>cAc	p.R377H	INHBA_ENST00000442711.1_Missense_Mutation_p.R377H|INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	377				RMR -> AC (in Ref. 7; CAA51163).	cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity	p.R377H(1)		biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GCCCCGCATGCGGTAGTGGTT	0.547										TSP Lung(11;0.080)			60	80					0	0	1	0	0	T	41729399	C	T	41729399	3	4	42	1	0	0	0	0	1	0	0	0	7784	768	27	1	154	1	INHBA	7	41729399	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		41729399	117409264	20	3915										
ZNF479	90827	broad.mit.edu	37	chr7	57188629	57188629	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	atttgaaaatttaccaaagaCtttgacatatttatgagtct	5	5	1	4			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr7:57188629C>G	ENST00000331162.4	-	5	763	c.493G>C	c.(493-495)Gtc>Ctc	p.V165L		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TTACCAAAGACTTTGACATAT	0.308													9	19					0	0	1	0	0	G	57188629	C	G	57188629	3	3	42	1	0	0	0	0	1	0	0	0	17989	565	20	5	1085	5	ZNF479	7	57188629	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	15459230	57188629	101950034	21	3916										
TBL2	26608	broad.mit.edu	37	chr7	72988397	72988397	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tgcgatcatctgcacaggtaGccaggtatttgccattgctg	11	10	2	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr7:72988397G>T	ENST00000305632.5	-	3	558	c.317C>A	c.(316-318)gCt>gAt	p.A106D	TBL2_ENST00000452475.1_Missense_Mutation_p.A106D|TBL2_ENST00000459913.1_5'UTR|TBL2_ENST00000432538.1_Missense_Mutation_p.A70D	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	106										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGCACAGGTAGCCAGGTATTT	0.577													13	50					2.27111e-07	2.30403e-07	1	1	0	T	72988397	G	T	72988397	3	4	42	1	0	0	0	0	1	0	0	0	15701	971	34	5	1046	5	TBL2	7	72988397	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	15799768	72988397	86150266	22	3917										
MET	0	broad.mit.edu	37	chr7	116340188	116340188	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggggtgttcgcacaaagcaaGccagattctgccgaaccaat	11	11	1	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr7:116340188G>T	ENST00000397752.3	+	2	1250	c.1050G>T	c.(1048-1050)aaG>aaT	p.K350N	MET_ENST00000318493.6_Missense_Mutation_p.K350N|MET_ENST00000436117.2_Missense_Mutation_p.K350N	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	350	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CACAAAGCAAGCCAGATTCTG	0.473			Mis		"papillary renal, head-neck squamous cell "	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				25	29					2.27525e-19	2.41315e-19	1	1	0	T	116340188	G	T	116340188	3	4	42	1	0	0	0	0	1	0	0	0	9534	962	34	5	1052	5	MET	7	116340188	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	43351791	116340188	42798475	23	3918										
DOCK5	80005	broad.mit.edu	37	chr8	25167977	25167977	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cctcacccaggttcagaagaAtttttcacacttggttgata	7	10	3	3	rs139621203	byFrequency	TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr8:25167977A>T	ENST00000276440.7	+	13	1291	c.1247A>T	c.(1246-1248)aAt>aTt	p.N416I		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	416						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GTTCAGAAGAATTTTTCACAC	0.423													15	17					0	0	1	0	0	T	25167977	A	T	25167977	3	4	42	1	0	0	0	0	1	0	0	0	4717	101	4	4	1297	4	DOCK5	8	25167977	Missense_Mutation	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08		25167977	121196045	24	3919										
UNC5D	137970	broad.mit.edu	37	chr8	35583958	35583958	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	aaataaaatgccctacatccAaaatctgtcatcactcccca	2	14	3	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr8:35583958A>G	ENST00000287272.2	+	9	1405	c.1385A>G	c.(1384-1386)cAa>cGa	p.Q462R	UNC5D_ENST00000449677.1_Missense_Mutation_p.Q107R|UNC5D_ENST00000453357.2_Missense_Mutation_p.Q526R|UNC5D_ENST00000420357.1_Missense_Mutation_p.Q464R|UNC5D_ENST00000416672.1_Missense_Mutation_p.Q536R|UNC5D_ENST00000404895.2_Missense_Mutation_p.Q531R			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	531					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCTACATCCAAAATCTGTCA	0.468													26	40					0	0	1	0	0	G	35583958	A	G	35583958	3	3	42	1	0	0	0	0	1	0	0	0	17054	130	5	4	1630	4	UNC5D	8	35583958	Missense_Mutation	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08	10415981	35583958	110780064	25	3920										
ZFAT	57623	broad.mit.edu	37	chr8	135524778	135524778	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cgctgcctgtgtcccttgaaCgtcttcttcggcctctgtga	10	14	3	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr8:135524778C>T	ENST00000520727.1	-	15	3564	c.3265G>A	c.(3265-3267)Gtt>Att	p.V1089I	ZFAT_ENST00000520214.1_Missense_Mutation_p.V1089I|ZFAT_ENST00000429442.2_Missense_Mutation_p.V1089I|ZFAT_ENST00000523399.1_Missense_Mutation_p.V1039I|ZFAT_ENST00000377838.3_Missense_Mutation_p.V1101I|ZFAT_ENST00000520356.1_Intron	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GTCCCTTGAACGTCTTCTTCG	0.532													55	321					0	0	1	0	0	T	135524778	C	T	135524778	3	4	42	1	0	0	0	0	1	0	0	0	17689	536	19	1	442	1	ZFAT	8	135524778	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	99940820	135524778	10839244	26	3921										
ADAMTS13	11093	broad.mit.edu	37	chr9	136305578	136305578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	agtacagagtggccctcaccGaggaccggctgccccgcctg	13	16	1	1	rs34569244		TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr9:136305578G>A	ENST00000371929.3	+	16	2344	c.1900G>A	c.(1900-1902)Gag>Aag	p.E634K	ADAMTS13_ENST00000536611.1_Missense_Mutation_p.E306K|ADAMTS13_ENST00000355699.2_Missense_Mutation_p.E634K|ADAMTS13_ENST00000356589.2_Missense_Mutation_p.E603K|ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000371916.1_3'UTR	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	634	Spacer.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GGCCCTCACCGAGGACCGGCT	0.647													19	24					0	0	1	0	0	A	136305578	G	A	136305578	3	1	42	1	0	0	0	0	1	0	0	0	257	1059	37	1	1962	1	ADAMTS13	9	136305578	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		136305578	4907853	27	3922										
KIAA1217	56243	broad.mit.edu	37	chr10	24762746	24762746	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tgcctctcctcacagagtcaGtgacctgaggatgatagaca	10	11	3	5			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr10:24762746G>A	ENST00000376451.2	+	2	850	c.590G>A	c.(589-591)aGt>aAt	p.S197N	KIAA1217_ENST00000430453.2_Missense_Mutation_p.S400N|KIAA1217_ENST00000307544.6_Missense_Mutation_p.S197N|KIAA1217_ENST00000396445.1_Missense_Mutation_p.S197N|KIAA1217_ENST00000396446.1_Missense_Mutation_p.S197N|KIAA1217_ENST00000376454.3_Missense_Mutation_p.S479N|KIAA1217_ENST00000458595.1_Missense_Mutation_p.S479N|KIAA1217_ENST00000376462.1_Missense_Mutation_p.S399N|KIAA1217_ENST00000376452.3_Missense_Mutation_p.S479N			Q5T5P2	SKT_HUMAN	KIAA1217	479					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CACAGAGTCAGTGACCTGAGG	0.542													25	95					0	0	1	0	0	A	24762746	G	A	24762746	3	1	42	1	0	0	0	0	1	0	0	0	8257	1029	36	3	1458	3	KIAA1217	10	24762746	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		24762746	110772001	28	3923										
DNMBP	23268	broad.mit.edu	37	chr10	101715317	101715317	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gctgggcgagagggtcgcacCaccaagggtggtgcaggttt	18	9	0	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr10:101715317C>G	ENST00000342239.3	-	4	2005	c.1914G>C	c.(1912-1914)gtG>gtC	p.V638V	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Silent_p.V638V			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	638	Pro-rich.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AGGGTCGCACCACCAAGGGTG	0.597													8	59					0	0	1	0	0	G	101715317	C	G	101715317	2	3	42	1	0	0	0	0	0	0	0	1	4701	581	21	5		5	DNMBP	10	101715317	Silent	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	76952571	101715317	33819430	29	3924										
DOCK1	1793	broad.mit.edu	37	chr10	128785806	128785806	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	caacatgaaacagtcatcccGggtgacctccccctcatcca	6	17	2	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr10:128785806G>A	ENST00000280333.6	+	5	358	c.249G>A	c.(247-249)ccG>ccA	p.P83P		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	83					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CAGTCATCCCGGGTGACCTCC	0.507													7	10					0	0	1	0	0	A	128785806	G	A	128785806	2	1	42	1	0	0	0	0	0	0	0	1	4711	1103	39	1		1	DOCK1	10	128785806	Silent	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	27070489	128785806	6748941	30	3925										
SLC17A6	57084	broad.mit.edu	37	chr11	22396405	22396405	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	aagcagattctttcaactacGacagtgagaaagatcatgaa	8	7	3	4	rs117003321		TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr11:22396405G>A	ENST00000263160.3	+	9	1583	c.1146G>A	c.(1144-1146)acG>acA	p.T382T		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	382					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						TTTCAACTACGACAGTGAGAA	0.368													40	108					0	0	1	0	0	A	22396405	G	A	22396405	2	1	42	1	0	0	0	0	0	0	0	1	14475	1045	37	1		1	SLC17A6	11	22396405	Silent	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		22396405	112610111	31	3926										
SUV420H1	51111	broad.mit.edu	37	chr11	67926336	67926336	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tggtccctctggctccttatCttttttaatgggcaaatttt	7	9	2	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr11:67926336C>G	ENST00000304363.4	-	11	1830	c.1477G>C	c.(1477-1479)Gat>Cat	p.D493H		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						GGCTCCTTATCTTTTTTAATG	0.478													45	44					0	0	1	0	0	G	67926336	C	G	67926336	3	3	42	1	0	0	0	0	1	0	0	0	15469	913	32	2	1184	2	SUV420H1	11	67926336	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	45529931	67926336	67080180	32	3927										
PGR	5241	broad.mit.edu	37	chr11	100999426	100999427	+	Frame_Shift_Ins	INS	-	-	C													0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggagggctgggttggctctgINScccgggacctgagggcgcca							TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr11:100999426_100999427insC	ENST00000325455.5	-	1	1828_1829	c.375_376insG	c.(373-378)ggagagfs	p.E126fs	PGR_ENST00000263463.5_Frame_Shift_Ins_p.E126fs|PGR_ENST00000534013.1_Intron	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	126	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	GGTTGGCTCTGCCCGGGACCTG	0.653													7	8	---	---	---	---						C	100999427	-	C	100999426	7	5	42	1	0	1	1	0	0	0	0	0	11852	1328	46	0	2457	0	PGR	11	100999426	Frame_Shift_Ins	INS	-	TCGA-NA-A4QY-01A-11D-A28R-08	33073090	100999426	34007090	33	3928										
CARKD	55739	broad.mit.edu	37	chr13	111287884	111287884	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tcagccaagccctgggcaacGtgacggtggtccagaaagga	14	11	1	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr13:111287884G>A	ENST00000309957.2	+	8	735	c.721G>A	c.(721-723)Gtg>Atg	p.V241M	CARKD_ENST00000458711.2_Missense_Mutation_p.V110M|CARKD_ENST00000470164.2_3'UTR|CARKD_ENST00000424185.2_Missense_Mutation_p.V131M	NM_001242881.1|NM_018210.3	NP_001229810.1|NP_060680.2	Q8IW45	CARKD_HUMAN	carbohydrate kinase domain containing	241	YjeF C-terminal.									NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	15						CCTGGGCAACGTGACGGTGGT	0.592													28	212					0	0	1	0	0	A	111287884	G	A	111287884	3	1	42	1	0	0	0	0	1	0	0	0	2672	1145	40	1	751	1	CARKD	13	111287884	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		111287884	3881994	34	3929										
MCF2L	23263	broad.mit.edu	37	chr13	113750979	113750979	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gcagctcaggtaaggcccacGtgccccgagcccacccgtga	12	17	1	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr13:113750979G>A	ENST00000375608.3	+	30	3452	c.3394G>A	c.(3394-3396)Gtg>Atg	p.V1132M	MCF2L_ENST00000442652.2_Missense_Mutation_p.V1132M|MCF2L_ENST00000375601.3_Intron|MCF2L_ENST00000423482.2_Intron|MCF2L_ENST00000397030.1_3'UTR|MCF2L_ENST00000535094.2_Intron|MCF2L_ENST00000434480.2_Missense_Mutation_p.V1108M|MCF2L_ENST00000375604.2_Intron			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	1132					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TAAGGCCCACGTGCCCCGAGC	0.741													5	15					0	0	1	0	0	A	113750979	G	A	113750979	3	1	42	1	0	0	0	0	1	0	0	0	9428	1160	40	1		1	MCF2L	13	113750979	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	2463095	113750979	1418899	35	3930										
SEC11A	23478	broad.mit.edu	37	chr15	85259282	85259282	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cttgttcatccgccgcacatCgtccaaaaagtctagagaca	7	13	2	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr15:85259282C>T	ENST00000268220.7	-	1	665	c.25G>A	c.(25-27)Gat>Aat	p.D9N	SEC11A_ENST00000560266.1_Missense_Mutation_p.D9N|SEC11A_ENST00000558134.1_Missense_Mutation_p.D9N|SEC11A_ENST00000455959.3_5'UTR	NM_014300.2	NP_055115.1	P67812	SC11A_HUMAN	SEC11 homolog A (S. cerevisiae)	9					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	protein binding|serine-type peptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(143;0.199)			CGCCGCACATCGTCCAAAAAG	0.642													8	15					0	0	1	0	0	T	85259282	C	T	85259282	3	4	42	1	0	0	0	0	1	0	0	0	14031	884	31	1	538	1	SEC11A	15	85259282	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		85259282	17272110	36	3931										
KLHL25	64410	broad.mit.edu	37	chr15	86312852	86312852	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	atagcggctagaggcggccaGcacggcacggtgacagggga	18	10	0	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr15:86312852G>C	ENST00000337975.5	-	2	464	c.190C>G	c.(190-192)Ctg>Gtg	p.L64V	KLHL25_ENST00000559131.1_Intron|KLHL25_ENST00000536947.1_Missense_Mutation_p.L64V	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	64	BTB.					cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						GAGGCGGCCAGCACGGCACGG	0.627													14	33					0	0	1	0	0	C	86312852	G	C	86312852	3	2	42	1	0	0	0	0	1	0	0	0	8422	962	34	5	1583	5	KLHL25	15	86312852	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	1053570	86312852	16218540	37	3932										
CRTC3	64784	broad.mit.edu	37	chr15	91073323	91073323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	catggccgcctcgccgggctCgggcagcgccaacccgcgga	15	18	0	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr15:91073323C>T	ENST00000420329.2	+	1	167	c.20C>T	c.(19-21)tCg>tTg	p.S7L	CRTC3_ENST00000560098.1_Missense_Mutation_p.S7L|CRTC3_ENST00000268184.6_Missense_Mutation_p.S7L	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	7	Required for interaction with HTLV-1 TAX.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			TCGCCGGGCTCGGGCAGCGCC	0.721			T	MAML2	salivary gland mucoepidermoid								5	3					0	0	1	0	0	T	91073323	C	T	91073323	3	4	42	1	0	0	0	0	1	0	0	0	3924	893	31	1	22	1	CRTC3	15	91073323	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	4760471	91073323	11458069	38	3933										
CRTC3	64784	broad.mit.edu	37	chr15	91172709	91172709	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	tggccctgaagcacatcaagGtttcagcagacagctgtctt	10	11	3	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr15:91172709G>A	ENST00000420329.2	+	11	1358	c.1211G>A	c.(1210-1212)gGt>gAt	p.G404D	CRTC3_ENST00000268184.6_Missense_Mutation_p.G404D|RP11-387D10.2_ENST00000559531.1_RNA	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	404					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			GCACATCAAGGTTTCAGCAGA	0.572			T	MAML2	salivary gland mucoepidermoid								46	95					0	0	1	0	0	A	91172709	G	A	91172709	3	1	42	1	0	0	0	0	1	0	0	0	3924	1261	44	3	1253	3	CRTC3	15	91172709	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	99386	91172709	11358683	39	3934										
HCFC1R1	54985	broad.mit.edu	37	chr16	3073870	3073870	+	Frame_Shift_Del	DEL	C	C	-													0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggcgtccaggccccaagtcaCccccaaggcggcccgcggga							TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr16:3073870delC	ENST00000248089.3	-	1	377	c.73delG	c.(73-75)tgfs	p.V25fs	HCFC1R1_ENST00000396916.1_Frame_Shift_Del_p.V25fs|HCFC1R1_ENST00000574151.1_Frame_Shift_Del_p.V25fs|HCFC1R1_ENST00000574980.1_Frame_Shift_Del_p.V25fs|HCFC1R1_ENST00000572355.1_Intron|HCFC1R1_ENST00000354679.3_Frame_Shift_Del_p.V25fs	NM_017885.2	NP_060355.1	Q9NWW0	HPIP_HUMAN	host cell factor C1 regulator 1 (XPO1 dependent)	25						cytoplasm|nucleus				breast(1)|large_intestine(1)|upper_aerodigestive_tract(1)	3						CCCCAAGTCACCCCCAAGGCG	0.701													2	4	---	---	---	---						-	3073870	C	-	3073870	7	5	42	1	0	1	0	1	0	0	0	0	7032	507	18	0	359	0	HCFC1R1	16	3073870	Frame_Shift_Del	DEL	C	TCGA-NA-A4QY-01A-11D-A28R-08		3073870	87280883	40	3935										
TP53	7157	broad.mit.edu	37	chr17	7577141	7577141	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gcacctcaaagctgttccgtCccagtagattaccactactc	6	15	1	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr17:7577141C>A	ENST00000420246.2	-	8	929	c.797G>T	c.(796-798)gGa>gTa	p.G266V	TP53_ENST00000445888.2_Missense_Mutation_p.G266V|TP53_ENST00000455263.2_Missense_Mutation_p.G266V|TP53_ENST00000359597.4_Missense_Mutation_p.G266V|TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.G266V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	266	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		G -> A (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(50)|p.G266V(42)|p.0?(8)|p.?(3)|p.G266fs*79(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGTTCCGTCCCAGTAGATT	0.517		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	4					0.0135373	0.0135373	1	1	0	A	7577141	C	A	7577141	3	1	42	1	0	0	0	0	1	0	0	0	16441	855	30	2	489	2	TP53	17	7577141	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		7577141	73618069	41	3936										
USP43	124739	broad.mit.edu	37	chr17	9631744	9631744	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	acctgcctctcactgtgatgCcttcagtggagcatgagaaa	10	11	2	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr17:9631744C>T	ENST00000570827.2	+	15	2950	c.1876C>T	c.(1876-1878)Cct>Tct	p.P626S	USP43_ENST00000285199.6_Missense_Mutation_p.P937S|USP43_ENST00000570475.1_Missense_Mutation_p.P932S			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	937					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						CACTGTGATGCCTTCAGTGGA	0.537													6	8					0	0	1	0	0	T	9631744	C	T	9631744	3	4	42	1	0	0	0	0	1	0	0	0	17133	739	26	3	2867	3	USP43	17	9631744	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	2054603	9631744	71563466	42	3937										
SUPT6H	6830	broad.mit.edu	37	chr17	27009799	27009799	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gcagtttggggagaacctgcGggatagctaccagcggcacg	16	10	0	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr17:27009799G>T	ENST00000314616.6	+	14	1935	c.1652G>T	c.(1651-1653)cGg>cTg	p.R551L	SUPT6H_ENST00000347486.4_Missense_Mutation_p.R551L	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	551					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					GAGAACCTGCGGGATAGCTAC	0.557													24	84					4.26978e-12	4.46096e-12	1	1	0	T	27009799	G	T	27009799	3	4	42	1	0	0	0	0	1	0	0	0	15455	1116	39	5	1702	5	SUPT6H	17	27009799	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	17378055	27009799	54185411	43	3938										
CRHR1	1394	broad.mit.edu	37	chr17	43907499	43907499	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	aacatcatccactggaacctCatctccgccttcatcctgcg	5	17	4	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr17:43907499C>A	ENST00000314537.5	+	6	699	c.474C>A	c.(472-474)ctC>ctA	p.L158L	CRHR1_ENST00000352855.5_Silent_p.L118L|CRHR1_ENST00000293493.7_5'UTR|CRHR1_ENST00000398285.3_Silent_p.L187L|CRHR1_ENST00000577353.1_Silent_p.L158L|CRHR1_ENST00000339069.5_Silent_p.L57L	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	187					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		ACTGGAACCTCATCTCCGCCT	0.622													86	97					5.70515e-31	6.144e-31	1	1	0	A	43907499	C	A	43907499	2	1	42	1	0	0	0	0	0	0	0	1	3894	813	29	2		2	CRHR1	17	43907499	Silent	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	16897700	43907499	37287711	44	3939										
SAMD4B	55095	broad.mit.edu	37	chr19	39869208	39869208	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	accagttacctccagctcatCgaaaagtgcctgactcatga	7	13	2	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr19:39869208C>T	ENST00000314471.6	+	11	2544	c.1509C>T	c.(1507-1509)atC>atT	p.I503I	SAMD4B_ENST00000598913.1_Silent_p.I503I|SAMD4B_ENST00000596368.1_Intron	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	503							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCCAGCTCATCGAAAAGTGCC	0.572													12	67					0	0	1	0	0	T	39869208	C	T	39869208	2	4	42	1	0	0	0	0	0	0	0	1	13873	874	31	1		1	SAMD4B	19	39869208	Silent	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		39869208	19259775	45	3940										
PVRL2	5819	broad.mit.edu	37	chr19	45368618	45368632	+	In_Frame_Del	DEL	TTCCTGGACTGTACA	TTCCTGGACTGTACA	-													0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gtgccacctgctgccacctgTtcctggactgtacatctccc							TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr19:45368618_45368632delTTCCTGGACTGTACA	ENST00000252483.5	+	2	179_193	c.179_193delTTCCTGGACTGTACA	c.(178-195)gtc>g	p.VPGLYI60del	PVRL2_ENST00000252485.4_In_Frame_Del_p.VPGLYI60del	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	60	Ig-like V-type.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CTGCCACCTGTTCCTGGACTGTACATCTCCCTGGT	0.656													19	71	---	---	---	---						-	45368632	TTCCTGGACTGTACA	-	45368618	7	5	42	1	0	1	0	1	0	0	0	0	12891	1725	60	0	185	0	PVRL2	19	45368618	In_Frame_Del	DEL	TTCCTGGACTGTACA	TCGA-NA-A4QY-01A-11D-A28R-08	5499410	45368618	13760365	46	3941										
ZNF808	388558	broad.mit.edu	37	chr19	53057634	53057634	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cttacaagtgtaatgagtgtCgcaagaccttcagccgcagg	11	10	1	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr19:53057634C>T	ENST00000359798.4	+	5	1645	c.1465C>T	c.(1465-1467)Cgc>Tgc	p.R489C		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TAATGAGTGTCGCAAGACCTT	0.433													37	128					0	0	1	0	0	T	53057634	C	T	53057634	3	4	42	1	0	0	0	0	1	0	0	0	18220	884	31	1	1475	1	ZNF808	19	53057634	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	7689016	53057634	6071349	47	3942										
TRMT6	51605	broad.mit.edu	37	chr20	5919371	5919371	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gatgacttcgatctggcaaaAcctaatcaagacagaaaaga	8	8	2	4			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr20:5919371A>C	ENST00000203001.2	-	11	1434	c.1302_splice	c.e11-1	p.V435_splice	TRMT6_ENST00000453074.2_Splice_Site_p.V265_splice|TRMT6_ENST00000473131.1_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	435					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						ATCTGGCAAAACCTAATCAAG	0.418													14	75					0	0	1	0	0	C	5919371	A	C	5919371	5	2	42	1	0	0	0	0	0	0	1	0	16628	57	2	4	193	4	TRMT6	20	5919371	Splice_Site	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08		5919371	57106149	48	3943										
PWP2	5822	broad.mit.edu	37	chr21	45544547	45544547	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cgtgtgcatctaccacgtccGtgagcagattctcatgaaga	10	11	2	4	rs144635092	byFrequency	TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr21:45544547G>A	ENST00000291576.7	+	15	2031	c.1904G>A	c.(1903-1905)cGt>cAt	p.R635H		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	635						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		TACCACGTCCGTGAGCAGATT	0.602													6	60					0	0	1	0	0	A	45544547	G	A	45544547	3	1	42	1	0	0	0	0	1	0	0	0	12895	1145	40	1	1962	1	PWP2	21	45544547	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		45544547	2585348	49	3944										
CLTCL1	8218	broad.mit.edu	37	chr22	19196494	19196494	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ggtcgtcccctctgatatagGagttgatggcttccttcacc	10	12	2	2			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr22:19196494G>C	ENST00000263200.10	-	21	3452	c.3380C>G	c.(3379-3381)tCc>tGc	p.S1127C	CLTCL1_ENST00000353891.5_Missense_Mutation_p.S1127C|CLTCL1_ENST00000427926.1_Missense_Mutation_p.S1127C	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1127	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TCTGATATAGGAGTTGATGGC	0.547			T	?	ALCL								16	7					0	0	1	0	0	C	19196494	G	C	19196494	3	2	42	1	0	0	0	0	1	0	0	0	3590	1174	41	2	1590	2	CLTCL1	22	19196494	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08		19196494	32108072	50	3945										
ARVCF	421	broad.mit.edu	37	chr22	19961226	19961226	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cagagcgatggcgacggcgcGcaccaccttgtcggtctcag	14	14	1	1			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr22:19961226G>A	ENST00000263207.3	-	13	2470	c.2179C>T	c.(2179-2181)Cgc>Tgc	p.R727C	ARVCF_ENST00000401994.1_Missense_Mutation_p.R664C|ARVCF_ENST00000344269.3_Missense_Mutation_p.R664C|ARVCF_ENST00000406522.1_Missense_Mutation_p.R658C|ARVCF_ENST00000406259.1_Missense_Mutation_p.R721C	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	727					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					GCGACGGCGCGCACCACCTTG	0.667													31	134					0	0	1	0	0	A	19961226	G	A	19961226	3	1	42	1	0	0	0	0	1	0	0	0	1002	1087	38	1	737	1	ARVCF	22	19961226	Missense_Mutation	SNP	G	TCGA-NA-A4QY-01A-11D-A28R-08	764732	19961226	31343340	51	3946										
EWSR1	2130	broad.mit.edu	37	chr22	29695296	29695296	+	Frame_Shift_Del	DEL	C	C	-													0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	gccccaaagcctgaaggcttCctcccgccaccctttccgcc							TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chr22:29695296delC	ENST00000397938.2	+	15	1972	c.1653delC	c.(1651-1653)ttfs	p.F551fs	EWSR1_ENST00000332035.6_Frame_Shift_Del_p.F495fs|EWSR1_ENST00000414183.2_Frame_Shift_Del_p.F556fs|EWSR1_ENST00000332050.6_Frame_Shift_Del_p.F478fs|EWSR1_ENST00000406548.1_Frame_Shift_Del_p.F550fs|EWSR1_ENST00000331029.7_Frame_Shift_Del_p.F513fs	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTGAAGGCTTCCTCCCGCCAC	0.522			T	"FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"	"Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"								85	132	---	---	---	---						-	29695296	C	-	29695296	7	5	42	1	0	1	0	1	0	0	0	0	5323	854	30	0	1828	0	EWSR1	22	29695296	Frame_Shift_Del	DEL	C	TCGA-NA-A4QY-01A-11D-A28R-08	9734070	29695296	21609270	52	3947										
GAGE2A	729447	broad.mit.edu	37	chrX	49355893	49355893	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	ctgcagctgctcaggagggaCaggatgagggagcatctgca	16	9	2	1	rs147803166	by1000genomes	TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chrX:49355893C>G	ENST00000362097.1	+	3	258	c.175C>G	c.(175-177)Cag>Gag	p.Q59E		NM_001127212.1	NP_001120684.1			G antigen 2A									p.Q59E(8)		endometrium(4)	4	Ovarian(276;0.236)					TCAGGAGGGACAGGATGAGGG	0.562													6	686					0	0	1	0	0	G	49355893	C	G	49355893	3	3	42	1	0	0	0	0	1	0	0	0	6225	479	17	5	1282	5	GAGE2A	23	49355893	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08		49355893	105914667	53	3948										
BMP15	9210	broad.mit.edu	37	chrX	50659329	50659329	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	accctttccaaatcagcttcCgccagctgggttgggatcac	9	14	2	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chrX:50659329C>T	ENST00000252677.3	+	2	901	c.901C>T	c.(901-903)Cgc>Tgc	p.R301C		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	301					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					AATCAGCTTCCGCCAGCTGGG	0.498													77	65					0	0	1	0	0	T	50659329	C	T	50659329	3	4	42	1	0	0	0	0	1	0	0	0	1457	652	23	1	907	1	BMP15	23	50659329	Missense_Mutation	SNP	C	TCGA-NA-A4QY-01A-11D-A28R-08	1303436	50659329	104611231	54	3949										
MAMLD1	10046	broad.mit.edu	37	chrX	149639635	149639635	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0727272727272727	4	1	0.786763338910578	2.4340490797546	0.259631901840491	0.523809523809524	1	0	cactgccaccttgcagctgcAgcagcagcagcagcaacagc	10	16	0	0			TCGA-NA-A4QY-01A-11D-A28R-08	TCGA-NA-A4QY-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	488e827e-d912-4b2e-9e0e-f0d442548c4f	a8ed63a8-ba8a-49c1-bf64-00388e7eb226	g.chrX:149639635A>T	ENST00000370401.2	+	4	2100	c.1790A>T	c.(1789-1791)cAg>cTg	p.Q597L	MAMLD1_ENST00000432680.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000455522.2_Missense_Mutation_p.Q78L|MAMLD1_ENST00000426613.2_Missense_Mutation_p.Q572L|MAMLD1_ENST00000262858.5_Missense_Mutation_p.Q597L			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	597	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					TTgcagctgcagcagcagcag	0.607													5	164					0	0	1	0	0	T	149639635	A	T	149639635	3	4	42	1	0	0	0	0	1	0	0	0	9257	188	7	4	1800	4	MAMLD1	23	149639635	Missense_Mutation	SNP	A	TCGA-NA-A4QY-01A-11D-A28R-08	98980306	149639635	5630925	55	3950										
HP1BP3	50809	broad.mit.edu	37	chr1	21100010	21100010	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gaagccatcggtgtttgtttCtgggccctggctagctggct	14	10	1	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:21100010C>A	ENST00000312239.5	-	5	583	c.444G>T	c.(442-444)caG>caT	p.Q148H	HP1BP3_ENST00000375003.2_5'UTR	NM_016287.3	NP_057371.2	Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	148					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GTGTTTGTTTCTGGGCCCTGG	0.423													17	44					4.75885e-15	5.77407e-15	1	1	0	A	21100010	C	A	21100010	3	1	43	1	0	0	0	0	1	0	0	0	7368	912	32	2	1253	2	HP1BP3	1	21100010	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		21100010	228150611	1	3951										
LYPLA2	11313	broad.mit.edu	37	chr1	24120731	24120731	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cagggcggggccctgtccctCtacacggccctcacctgccc	11	20	2	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:24120731C>G	ENST00000400061.1	+	7	434	c.313C>G	c.(313-315)Cta>Gta	p.L105V	LYPLA2_ENST00000374514.3_Silent_p.L129L|LYPLA2_ENST00000495365.1_3'UTR|LYPLA2_ENST00000374505.2_Missense_Mutation_p.L105V|LYPLA2_ENST00000374501.1_Silent_p.L62L|LYPLA2_ENST00000374503.3_Silent_p.L129L|LYPLA2_ENST00000374502.3_Silent_p.L129L			O95372	LYPA2_HUMAN	lysophospholipase II	0					fatty acid metabolic process	cytoplasm	hydrolase activity			endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		CCCTGTCCCTCTACACGGCCC	0.701													4	25					0	0	1	0	0	G	24120731	C	G	24120731	3	3	43	1	0	0	0	0	1	0	0	0	9162	900	32	2	413	2	LYPLA2	1	24120731	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	3020721	24120731	225129890	2	3952										
IPP	3652	broad.mit.edu	37	chr1	46184897	46184898	+	Frame_Shift_Del	DEL	AC	AC	-													0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aaagcatagatagccccataAcacacacacactcctaagcc							TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:46184897_46184898delAC	ENST00000396478.3	-	6	1265_1266	c.1163_1164delGT	c.(1162-1164)tfs	p.C388fs		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	388						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TAGCCCCATAACACACACACAC	0.347													7	68	---	---	---	---						-	46184898	AC	-	46184897	7	5	43	1	0	1	0	1	0	0	0	0	7843	41	2	0	708	0	IPP	1	46184897	Frame_Shift_Del	DEL	AC	TCGA-NA-A4R0-01A-11D-A28R-08	22064166	46184897	203065724	3	3953										
TARS2	80222	broad.mit.edu	37	chr1	150478148	150478148	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ccctcagccggagaatccgcCgggcccagcttgcccactac	10	19	1	1	rs146012895		TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:150478148C>A	ENST00000369064.3	+	17	2009	c.1975C>A	c.(1975-1977)Cgg>Agg	p.R659R	TARS2_ENST00000606933.1_Silent_p.R577R|TARS2_ENST00000369054.2_Silent_p.R529R	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	659					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GAGAATCCGCCGGGCCCAGCT	0.557													5	98					0.000602214	0.000622744	1	1	0	A	150478148	C	A	150478148	2	1	43	1	0	0	0	0	0	0	0	1	15616	643	23	5		5	TARS2	1	150478148	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	104293251	150478148	98772473	4	3954										
C1orf43	25912	broad.mit.edu	37	chr1	154186393	154186393	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggtacgaatggcatccagagCtttcatcctatacagatagt	9	9	1	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:154186393C>G	ENST00000368521.5	-	4	514	c.316G>C	c.(316-318)Gct>Cct	p.A106P	C1orf43_ENST00000350592.3_Missense_Mutation_p.A72P|C1orf43_ENST00000362076.4_Intron|C1orf43_ENST00000368516.1_Missense_Mutation_p.A72P|C1orf43_ENST00000368519.1_Intron|C1orf43_ENST00000368518.1_Missense_Mutation_p.A106P	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	106						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					GCATCCAGAGCTTTCATCCTA	0.488													32	103					0	0	1	0	0	G	154186393	C	G	154186393	3	3	43	1	0	0	0	0	1	0	0	0	2054	797	28	5	461	5	C1orf43	1	154186393	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	3708245	154186393	95064228	5	3955										
FCRL3	115352	broad.mit.edu	37	chr1	157665945	157665945	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	agaacatgcagctctgccaaCagggaacgctgggtctttct	11	11	3	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:157665945C>A	ENST00000368184.3	-	7	1308	c.1017G>T	c.(1015-1017)ctG>ctT	p.L339L	FCRL3_ENST00000368186.5_Silent_p.L339L|RP11-367J7.3_ENST00000453692.1_RNA|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	339	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GCTCTGCCAACAGGGAACGCT	0.522													22	65					3.5997e-14	4.31017e-14	1	1	0	A	157665945	C	A	157665945	2	1	43	1	0	0	0	0	0	0	0	1	5828	465	17	5		5	FCRL3	1	157665945	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	3479552	157665945	91584676	6	3956										
PYCR2	29920	broad.mit.edu	37	chr1	226109286	226109286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ccccgagttggattgccaggCgccgtggcaaacccatcttc	11	15	1	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr1:226109286C>T	ENST00000343818.6	-	5	747	c.599G>A	c.(598-600)cGc>cAc	p.R200H	RP4-559A3.7_ENST00000432920.2_Missense_Mutation_p.R126H|PYCR2_ENST00000478402.1_5'UTR	NM_013328.2	NP_037460.2	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member 2	200					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity			kidney(1)|lung(3)	4	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	GATTGCCAGGCGCCGTGGCAA	0.572													25	46					0	0	1	0	0	T	226109286	C	T	226109286	3	4	43	1	0	0	0	0	1	0	0	0	12907	768	27	1	375	1	PYCR2	1	226109286	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	68443341	226109286	23141335	7	3957										
RNF181	51255	broad.mit.edu	37	chr2	85822893	85822893	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aaggctgggcagccatggcgTcctatttcgatgaacacgac	12	11	0	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr2:85822893T>C	ENST00000441634.1	+	1	46	c.7T>C	c.(7-9)Tcc>Ccc	p.S3P	RNF181_ENST00000306368.4_Missense_Mutation_p.S3P			Q9P0P0	RN181_HUMAN	ring finger protein 181	3							ligase activity|zinc ion binding			lung(1)|stomach(1)	2						AGCCATGGCGTCCTATTTCGA	0.642													6	41					0	0	1	0	0	C	85822893	T	C	85822893	3	2	43	1	0	0	0	0	1	0	0	0	13516	1667	58	4	9	4	RNF181	2	85822893	Missense_Mutation	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08		85822893	157376480	8	3958										
GLI2	2736	broad.mit.edu	37	chr2	121732502	121732502	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	acagcgacctcttttcagggCcaggtgtctggacacggctc	12	13	3	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr2:121732502C>A	ENST00000452319.1	+	9	1245	c.1185C>A	c.(1183-1185)ggC>ggA	p.G395G	GLI2_ENST00000435313.2_Intron|GLI2_ENST00000361492.4_Silent_p.G395G|GLI2_ENST00000314490.11_Silent_p.G67G			P10070	GLI2_HUMAN	GLI family zinc finger 2	395					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CTTTTCAGGGCCAGGTGTCTG	0.567													15	72					3.35478e-16	4.12547e-16	1	1	0	A	121732502	C	A	121732502	2	1	43	1	0	0	0	0	0	0	0	1	6479	726	26	5		5	GLI2	2	121732502	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	35909609	121732502	121466871	9	3959										
PLA2R1	0	broad.mit.edu	37	chr2	160801542	160801542	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ctgtgtctggcttccgaatgCcccagtttgactggtctgtg	12	11	2	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr2:160801542C>A	ENST00000283243.7	-	28	4225	c.4019G>T	c.(4018-4020)gGc>gTc	p.G1340V		NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	1340	C-type lectin 8.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						CTTCCGAATGCCCCAGTTTGA	0.433													13	35					7.03913e-09	7.90815e-09	1	1	0	A	160801542	C	A	160801542	3	1	43	1	0	0	0	0	1	0	0	0	12057	739	26	5	384	5	PLA2R1	2	160801542	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	39069040	160801542	82397831	10	3960										
WNT7A	7476	broad.mit.edu	37	chr3	13896248	13896248	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gtacaggcagctgtgatggcGtgggccacgccggcggcaat	17	11	0	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr3:13896248G>A	ENST00000285018.4	-	3	655	c.351C>T	c.(349-351)caC>caT	p.H117H		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	117					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						CTGTGATGGCGTGGGCCACGC	0.642													21	93					0	0	1	0	0	A	13896248	G	A	13896248	2	1	43	1	0	0	0	0	0	0	0	1	17453	1136	40	1		1	WNT7A	3	13896248	Silent	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08		13896248	184126182	11	3961										
SCN10A	6336	broad.mit.edu	37	chr3	38798315	38798315	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tagaaagatcccaggaagatTacgagcacaaaaaagatcat	8	7	1	4			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr3:38798315T>G	ENST00000449082.2	-	9	1139	c.1140A>C	c.(1138-1140)gtA>gtC	p.V380V		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	380					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCAGGAAGATTACGAGCACAA	0.463													18	140					0	0	1	0	0	G	38798315	T	G	38798315	2	3	43	1	0	0	0	0	0	0	0	1	13965	1741	61	4		4	SCN10A	3	38798315	Silent	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	24902067	38798315	159224115	12	3962										
SEC61A1	29927	broad.mit.edu	37	chr3	127786361	127786361	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tggctccgtgttagaagaccCggtccatgcagttgtataca	11	10	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr3:127786361C>T	ENST00000243253.3	+	10	1257	c.1073C>T	c.(1072-1074)cCg>cTg	p.P358L	SEC61A1_ENST00000424880.2_Missense_Mutation_p.P238L|SEC61A1_ENST00000483956.1_3'UTR|RUVBL1_ENST00000464873.1_Intron|SEC61A1_ENST00000464451.1_Missense_Mutation_p.P364L	NM_013336.3	NP_037468.1	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit (S. cerevisiae)	358					protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|prostate(4)	21						TTAGAAGACCCGGTCCATGCA	0.512													14	96					0	0	1	0	0	T	127786361	C	T	127786361	3	4	43	1	0	0	0	0	1	0	0	0	14053	652	23	1	1111	1	SEC61A1	3	127786361	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	88988046	127786361	70236069	13	3963										
PIK3CA	5290	broad.mit.edu	37	chr3	178936092	178936092	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tcctctctctgaaatcactgAgcaggagaaagattttctat	7	9	4	4	rs121913274		TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr3:178936092A>C	ENST00000263967.3	+	10	1791	c.1634A>C	c.(1633-1635)gAg>gCg	p.E545A		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545A(96)|p.E545G(78)|p.E545V(4)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAATCACTGAGCAGGAGAAA	0.353	E545A(AGS_STOMACH)|E545G(KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			7	19					0	0	1	0	0	C	178936092	A	C	178936092	3	2	43	1	0	0	0	0	1	0	0	0	11960	304	11	4	1668	4	PIK3CA	3	178936092	Missense_Mutation	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08	51149731	178936092	19086338	14	3964										
KLB	152831	broad.mit.edu	37	chr4	39408897	39408897	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	atggaaaaggaccttctataTgggatcatttcatccacaca	7	9	3	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr4:39408897T>C	ENST00000257408.4	+	1	425	c.328T>C	c.(328-330)Tgg>Cgg	p.W110R		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	110	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						ACCTTCTATATGGGATCATTT	0.413													16	43					0	0	1	0	0	C	39408897	T	C	39408897	3	2	43	1	0	0	0	0	1	0	0	0	8374	1464	51	4	330	4	KLB	4	39408897	Missense_Mutation	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08		39408897	151745379	15	3965										
PRDM8	56978	broad.mit.edu	37	chr4	81123265	81123265	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aagaccagcagcagcagcagCaggaggcacctttaggcccg	13	13	0	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr4:81123265C>G	ENST00000339711.4	+	10	1880	c.649C>G	c.(649-651)Cag>Gag	p.Q217E	PRDM8_ENST00000415738.2_Missense_Mutation_p.Q217E|PRDM8_ENST00000504452.1_Missense_Mutation_p.Q217E	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	217	Gly-rich.|Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcagcagcagcagGAGGCACC	0.672											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	90					0	0	1	0	0	G	81123265	C	G	81123265	3	3	43	1	0	0	0	0	1	0	0	0	12513	711	25	5	659	5	PRDM8	4	81123265	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	41714368	81123265	110031011	16	3966										
ENPEP	2028	broad.mit.edu	37	chr4	111430866	111430866	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggagaactggggactcatcaCgtacagagaaacgaacctgc	12	10	2	2	rs151125401		TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr4:111430866C>T	ENST00000265162.5	+	5	1439	c.1097C>T	c.(1096-1098)aCg>aTg	p.T366M		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	366					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GGACTCATCACGTACAGAGAA	0.453													15	90					0	0	1	0	0	T	111430866	C	T	111430866	3	4	43	1	0	0	0	0	1	0	0	0	5156	536	19	1	1115	1	ENPEP	4	111430866	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	30307601	111430866	79723410	17	3967										
HAPLN1	1404	broad.mit.edu	37	chr5	82940357	82940357	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gcattgcaccagtccagcccGccccgccaggcgtcgtacag	11	18	0	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr5:82940357G>A	ENST00000274341.4	-	4	1450	c.600C>T	c.(598-600)ggC>ggT	p.G200G		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	200	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		AGTCCAGCCCGCCCCGCCAGG	0.622													16	50					0	0	1	0	0	A	82940357	G	A	82940357	2	1	43	1	0	0	0	0	0	0	0	1	6994	1074	38	1		1	HAPLN1	5	82940357	Silent	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08		82940357	97974903	18	3968										
PCDHA7	0	broad.mit.edu	37	chr5	140214339	140214339	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ccatgtggacgtggaggtgaAggacattaacgacaaccctc	12	10	0	1	rs61730624		TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr5:140214339A>G	ENST00000525929.1	+	1	371	c.371A>G	c.(370-372)aAg>aGg	p.K124R	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.K124R|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGAGGTGAAGGACATTAAC	0.607													20	227					0	0	1	0	0	G	140214339	A	G	140214339	3	3	43	1	0	0	0	0	1	0	0	0	11575	72	3	4	373	4	PCDHA7	5	140214339	Missense_Mutation	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08	57273982	140214339	40700921	19	3969										
PCDHGA6	0	broad.mit.edu	37	chr5	140754980	140754980	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tcatctctctaaatgtggcaGacaccaacgacaacccgccc	6	16	3	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr5:140754980G>A	ENST00000517434.1	+	1	1330	c.1330G>A	c.(1330-1332)Gac>Aac	p.D444N	PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATGTGGCAGACACCAACGA	0.498													23	161					0	0	1	0	0	A	140754980	G	A	140754980	3	1	43	1	0	0	0	0	1	0	0	0	11604	942	33	3	1332	3	PCDHGA6	5	140754980	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	540641	140754980	40160280	20	3970										
UST	10090	broad.mit.edu	37	chr6	149395011	149395011	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gactgtgacggtgaagaagaCtgtcccctctcctgaggctg	13	11	1	5			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr6:149395011C>A	ENST00000367463.4	+	8	1083	c.980C>A	c.(979-981)aCt>aAt	p.T327N	UST_ENST00000466695.1_3'UTR	NM_005715.2	NP_005706.1	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	327					protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(2)	12		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		GTGAAGAAGACTGTCCCCTCT	0.527													17	39					4.7546e-09	5.40836e-09	1	1	0	A	149395011	C	A	149395011	3	1	43	1	0	0	0	0	1	0	0	0	17152	565	20	5	1010	5	UST	6	149395011	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		149395011	21720056	21	3971										
IGFBP1	3484	broad.mit.edu	37	chr7	45928490	45928490	+	Frame_Shift_Del	DEL	G	G	-													0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggcgactgcacgctgcgcccGgggactcagttgccgcgcgc							TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr7:45928490delG	ENST00000275525.3	+	1	535	c.239delG	c.(238-240)cgfs	p.R80fs	IGFBP1_ENST00000457280.1_Frame_Shift_Del_p.R80fs|IGFBP1_ENST00000468955.1_Frame_Shift_Del_p.R80fs	NM_000596.2	NP_000587.1	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	80	IGFBP N-terminal.					extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						CGCTGCGCCCGGGGACTCAGT	0.756													2	4	---	---	---	---						-	45928490	G	-	45928490	7	5	43	1	0	1	0	1	0	0	0	0	7621	1116	39	0	241	0	IGFBP1	7	45928490	Frame_Shift_Del	DEL	G	TCGA-NA-A4R0-01A-11D-A28R-08		45928490	113210173	22	3972										
POM121L12	285877	broad.mit.edu	37	chr7	53103788	53103788	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gcccggtgaccatcgggatcGcgccccctgagcgtcaggag	15	15	1	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr7:53103788G>A	ENST00000408890.4	+	1	440	c.424G>A	c.(424-426)Gcg>Acg	p.A142T		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	142										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CATCGGGATCGCGCCCCCTGA	0.721													10	49					0	0	1	0	0	A	53103788	G	A	53103788	3	1	43	1	0	0	0	0	1	0	0	0	12288	1087	38	1	426	1	POM121L12	7	53103788	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	7175298	53103788	106034875	23	3973										
CLDN4	1364	broad.mit.edu	37	chr7	73245572	73245572	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggtaatgggcatcgcgctggCcgtcctgggctggctggccg	18	12	0	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr7:73245572C>G	ENST00000435050.1	+	2	2721	c.41C>G	c.(40-42)gCc>gGc	p.A14G	CLDN4_ENST00000340958.2_Missense_Mutation_p.A14G|CLDN4_ENST00000431918.1_Missense_Mutation_p.A14G			O14493	CLD4_HUMAN	claudin 4	14					calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity			kidney(2)|lung(4)|urinary_tract(1)	7		Lung NSC(55;0.159)				ATCGCGCTGGCCGTCCTGGGC	0.657													8	99					0	0	1	0	0	G	73245572	C	G	73245572	3	3	43	1	0	0	0	0	1	0	0	0	3510	739	26	5	43	5	CLDN4	7	73245572	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	20141784	73245572	85893091	24	3974										
RSBN1L	222194	broad.mit.edu	37	chr7	77378907	77378907	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ctaactgatgttgaagatcaAgcagccaaaggcatcctaaa	8	9	1	3			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr7:77378907A>G	ENST00000334955.7	+	3	897	c.870A>G	c.(868-870)caA>caG	p.Q290Q	RSBN1L_ENST00000445288.1_Silent_p.Q20Q	NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	290						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTGAAGATCAAGCAGCCAAAG	0.368													10	73					0	0	1	0	0	G	77378907	A	G	77378907	2	3	43	1	0	0	0	0	0	0	0	1	13748	69	3	4		4	RSBN1L	7	77378907	Silent	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08	4133335	77378907	81759756	25	3975										
PDIA4	9601	broad.mit.edu	37	chr7	148718139	148718139	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gcatcatttaggaccaagacTccattttcttccttaacttc	4	12	2	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr7:148718139T>C	ENST00000286091.4	-	2	421	c.189A>G	c.(187-189)ggA>ggG	p.G63G		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	63	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			GGACCAAGACTCCATTTTCTT	0.418													7	22					0	0	1	0	0	C	148718139	T	C	148718139	2	2	43	1	0	0	0	0	0	0	0	1	11716	1538	54	4		4	PDIA4	7	148718139	Silent	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	71339232	148718139	10420524	26	3976										
PXDNL	137902	broad.mit.edu	37	chr8	52320810	52320810	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aataagccgcggagaagagcCtctgggtcagctcaggactg	14	10	3	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr8:52320810C>A	ENST00000356297.4	-	17	3474	c.3374G>T	c.(3373-3375)aGg>aTg	p.R1125M	PXDNL_ENST00000543296.1_Missense_Mutation_p.R1125M	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1125					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGAGAAGAGCCTCTGGGTCAG	0.577													27	99					1.2476e-16	1.55523e-16	1	1	0	A	52320810	C	A	52320810	3	1	43	1	0	0	0	0	1	0	0	0	12899	681	24	5	1045	5	PXDNL	8	52320810	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		52320810	94043212	27	3977										
STK3	6788	broad.mit.edu	37	chr8	99539092	99539092	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cttattcttgaagtcttgctTatcaaagtagtccatgaaag	7	7	3	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr8:99539092T>C	ENST00000523601.1	-	12	1678	c.1279A>G	c.(1279-1281)Aag>Gag	p.K427E	STK3_ENST00000419617.2_Missense_Mutation_p.K399E	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	399					apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		AAGTCTTGCTTATCAAAGTAG	0.363													20	60					0	0	1	0	0	C	99539092	T	C	99539092	3	2	43	1	0	0	0	0	1	0	0	0	15350	1763	61	4	288	4	STK3	8	99539092	Missense_Mutation	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	47218282	99539092	46824930	28	3978										
ZFAT	57623	broad.mit.edu	37	chr8	135521992	135521992	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ccgtggggtccagtcggtcgCcttaagaggaagaagcaaag	15	9	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr8:135521992C>T	ENST00000520727.1	-	16	3625	c.3325_splice	c.e16-1	p.G1109_splice	ZFAT_ENST00000520356.1_Intron|ZFAT_ENST00000520214.1_Splice_Site_p.G1109_splice|ZFAT_ENST00000377838.3_Splice_Site_p.G1121_splice|ZFAT_ENST00000429442.2_Splice_Site_p.G1109_splice|ZFAT_ENST00000523399.1_Splice_Site_p.G1059_splice	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	1121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CAGTCGGTCGCCTTAAGAGGA	0.587													26	144					0	0	1	0	0	T	135521992	C	T	135521992	5	4	43	1	0	0	0	0	0	0	1	0	17689	753	26	3	377	3	ZFAT	8	135521992	Splice_Site	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	35982900	135521992	10842030	29	3979										
ZNF462	58499	broad.mit.edu	37	chr9	109691937	109691937	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ctcacacttgaacattcacaAtgaggaattccagaagcgtg	8	10	2	3			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr9:109691937A>G	ENST00000277225.5	+	3	6033	c.5744A>G	c.(5743-5745)aAt>aGt	p.N1915S	ZNF462_ENST00000457913.1_Missense_Mutation_p.N1915S|ZNF462_ENST00000441147.2_Missense_Mutation_p.N760S			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1915					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AACATTCACAATGAGGAATTC	0.493													17	47					0	0	1	0	0	G	109691937	A	G	109691937	3	3	43	1	0	0	0	0	1	0	0	0	17982	101	4	4	5750	4	ZNF462	9	109691937	Missense_Mutation	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08		109691937	31521494	30	3980										
OR1L8	138881	broad.mit.edu	37	chr9	125330723	125330723	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gagtcccaggaggataaactCggagacactgctggtgtggt	15	8	0	1	rs143007621		TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr9:125330723C>T	ENST00000304865.2	-	1	115	c.34G>A	c.(34-36)Gag>Aag	p.E12K		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						AGGATAAACTCGGAGACACTG	0.458													4	61					0	0	1	0	0	T	125330723	C	T	125330723	3	4	43	1	0	0	0	0	1	0	0	0	11014	893	31	1	899	1	OR1L8	9	125330723	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	15638786	125330723	15882708	31	3981										
MYO3A	53904	broad.mit.edu	37	chr10	26434431	26434431	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggagacccaaaagaatggaaCttagttttggaattcaccat	9	7	1	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr10:26434431C>A	ENST00000265944.5	+	22	2639	c.2473C>A	c.(2473-2475)Ctt>Att	p.L825I	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	825	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AAGAATGGAACTTAGTTTTGG	0.328													5	29					4.096e-09	4.77867e-09	1	1	0	A	26434431	C	A	26434431	3	1	43	1	0	0	0	0	1	0	0	0	10123	565	20	5	2551	5	MYO3A	10	26434431	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		26434431	109100316	32	3982										
PCDH15	65217	broad.mit.edu	37	chr10	55943228	55943228	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	atgacactgtccccaggtctCatgtctgtataaacatacac	6	12	2	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr10:55943228C>T	ENST00000373965.2	-	14	1981	c.1587G>A	c.(1585-1587)atG>atA	p.M529I	PCDH15_ENST00000395430.1_Missense_Mutation_p.M522I|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.M522I|PCDH15_ENST00000395432.2_Missense_Mutation_p.M485I|PCDH15_ENST00000414778.1_Missense_Mutation_p.M527I|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.M500I|PCDH15_ENST00000395438.1_Missense_Mutation_p.M522I|PCDH15_ENST00000437009.1_Missense_Mutation_p.M522I|PCDH15_ENST00000361849.3_Missense_Mutation_p.M522I|PCDH15_ENST00000409834.1_Missense_Mutation_p.M133I|PCDH15_ENST00000373955.1_Missense_Mutation_p.M522I|PCDH15_ENST00000395445.1_Missense_Mutation_p.M529I|PCDH15_ENST00000395446.1_Missense_Mutation_p.M522I|PCDH15_ENST00000373957.3_Missense_Mutation_p.M500I	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	522	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CCCCAGGTCTCATGTCTGTAT	0.378										HNSCC(58;0.16)			4	59					0	0	1	0	0	T	55943228	C	T	55943228	3	4	43	1	0	0	0	0	1	0	0	0	11557	826	29	3	6004	3	PCDH15	10	55943228	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	29508797	55943228	79591519	33	3983										
COX15	1355	broad.mit.edu	37	chr10	101491747	101491747	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggcgctgccctaggagccagGagcggcagatactgcctccc	14	15	0	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr10:101491747G>A	ENST00000370483.5	-	1	110	c.60C>T	c.(58-60)ctC>ctT	p.L20L	CUTC_ENST00000493385.1_Intron|COX15_ENST00000016171.5_Silent_p.L20L	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	20					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		TAGGAGCCAGGAGCGGCAGAT	0.612													5	15					0	0	1	0	0	A	101491747	G	A	101491747	2	1	43	1	0	0	0	0	0	0	0	1	3787	1161	41	3		3	COX15	10	101491747	Silent	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	45548519	101491747	34043000	34	3984										
PYGM	5837	broad.mit.edu	37	chr11	64519437	64519437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ggaggcagttgaggagctgtCgtttatattcgtgaatccgc	14	7	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr11:64519437C>T	ENST00000164139.3	-	14	2125	c.1727G>A	c.(1726-1728)cGa>cAa	p.R576Q	PYGM_ENST00000377432.3_Missense_Mutation_p.R488Q|PYGM_ENST00000462303.1_5'UTR	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	576					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding	p.R576Q(1)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GAGGAGCTGTCGTTTATATTC	0.517													9	83					0	0	1	0	0	T	64519437	C	T	64519437	3	4	43	1	0	0	0	0	1	0	0	0	12913	884	31	1	829	1	PYGM	11	64519437	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		64519437	70487079	35	3985										
TRPC6	7225	broad.mit.edu	37	chr11	101362360	101362360	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cgtgatcaccactctggagcGtttcaacatccccattcaga	7	14	4	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr11:101362360G>A	ENST00000344327.3	-	3	1479	c.1055C>T	c.(1054-1056)aCg>aTg	p.T352M	TRPC6_ENST00000532133.1_Missense_Mutation_p.T352M|TRPC6_ENST00000348423.4_Intron|TRPC6_ENST00000360497.4_Missense_Mutation_p.T352M	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	352					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ACTCTGGAGCGTTTCAACATC	0.438													26	61					0	0	1	0	0	A	101362360	G	A	101362360	3	1	43	1	0	0	0	0	1	0	0	0	16643	1145	40	1	1784	1	TRPC6	11	101362360	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	36842923	101362360	33644156	36	3986										
KRT76	51350	broad.mit.edu	37	chr12	53162588	53162588	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cagacttgtagccacttcctCcagaagtctggatgctgcca	9	13	1	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr12:53162588C>A	ENST00000332411.2	-	9	1879	c.1826G>T	c.(1825-1827)gGa>gTa	p.G609V		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	609	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCCACTTCCTCCAGAAGTCTG	0.582													15	95					4.7546e-09	5.40836e-09	1	1	0	A	53162588	C	A	53162588	3	1	43	1	0	0	0	0	1	0	0	0	8531	855	30	2	94	2	KRT76	12	53162588	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		53162588	80689307	37	3987										
NACA	4666	broad.mit.edu	37	chr12	57111096	57111096	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ttgggggagagaggaatcacTgctggggaagtggggtcccc	19	7	1	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr12:57111096T>C	ENST00000454682.1	-	3	4499	c.4218A>G	c.(4216-4218)gcA>gcG	p.A1406A	NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						GAGGAATCACTGCTGGGGAAG	0.597			T	BCL6	NHL								12	26					0	0	1	0	0	C	57111096	T	C	57111096	2	2	43	1	0	0	0	0	0	0	0	1	10180	1567	55	4		4	NACA	12	57111096	Silent	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	3948508	57111096	76740799	38	3988										
MARS	4141	broad.mit.edu	37	chr12	57882857	57882857	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cctgtcttgcagctggatagCggcaactacctcttctccac	8	15	3	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr12:57882857C>T	ENST00000262027.5	+	2	299	c.165C>T	c.(163-165)agC>agT	p.S55S	MARS_ENST00000447721.2_Intron|MARS_ENST00000315473.5_5'UTR	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	55					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	AGCTGGATAGCGGCAACTACC	0.483													11	78					0	0	1	0	0	T	57882857	C	T	57882857	2	4	43	1	0	0	0	0	0	0	0	1	9365	767	27	1		1	MARS	12	57882857	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	771761	57882857	75969038	39	3989										
PXN	5829	broad.mit.edu	37	chr12	120652778	120652778	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	acgaagtgctcggggtgccaCgtcttccccatggcggtcac	13	14	2	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr12:120652778C>T	ENST00000397506.3	-	6	1617	c.564G>A	c.(562-564)acG>acA	p.T188T	PXN_ENST00000424649.2_Silent_p.T342T|PXN_ENST00000228307.7_Silent_p.T376T|PXN_ENST00000267257.7_Silent_p.T390T|PXN_ENST00000538144.1_5'UTR|PXN_ENST00000536957.1_Silent_p.T374T|PXN_ENST00000458477.2_Silent_p.T209T			P49023	PAXI_HUMAN	paxillin	376					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGGGTGCCACGTCTTCCCCA	0.642													5	29					0	0	1	0	0	T	120652778	C	T	120652778	2	4	43	1	0	0	0	0	0	0	0	1	12903	523	19	1		1	PXN	12	120652778	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	62769921	120652778	13199117	40	3990										
FANCM	57697	broad.mit.edu	37	chr14	45636162	45636162	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tgtttttacagatttataatCagagtcagtccaacaaaaga	6	6	2	3			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr14:45636162C>A	ENST00000267430.5	+	11	1883	c.1798C>A	c.(1798-1800)Cag>Aag	p.Q600K	FANCM_ENST00000556036.1_Missense_Mutation_p.Q600K|FANCM_ENST00000542564.2_Missense_Mutation_p.Q574K	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	600	Helicase C-terminal.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GATTTATAATCAGAGTCAGTC	0.279								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				13	41					4.3838e-07	4.86495e-07	1	1	0	A	45636162	C	A	45636162	3	1	43	1	0	0	0	0	1	0	0	0	5703	827	29	2	1840	2	FANCM	14	45636162	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		45636162	61713378	41	3991										
NDN	4692	broad.mit.edu	37	chr15	23931765	23931765	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tctctggcgccgcggcccttCacgtagatgaggctcaggat	13	13	3	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr15:23931765C>G	ENST00000331837.4	-	1	685	c.600G>C	c.(598-600)gtG>gtC	p.V200V		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	200	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CGCGGCCCTTCACGTAGATGA	0.662									Prader-Willi syndrome				12	46					0	0	1	0	0	G	23931765	C	G	23931765	2	3	43	1	0	0	0	0	0	0	0	1	10293	813	29	2		2	NDN	15	23931765	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		23931765	78599627	42	3992										
NEDD4	4734	broad.mit.edu	37	chr15	56209012	56209012	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cttctggctgcaaagtgcaaTcgtaagctttgtgccatttg	10	9	1	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr15:56209012T>A	ENST00000508342.1	-	1	317	c.18A>T	c.(16-18)cgA>cgT	p.R6R	NEDD4_ENST00000506154.1_Silent_p.R6R|NEDD4_ENST00000435532.3_Intron|NEDD4_ENST00000338963.2_Silent_p.R6R			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	6					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CAAAGTGCAATCGTAAGCTTT	0.443													11	101					0	0	1	0	0	A	56209012	T	A	56209012	2	1	43	1	0	0	0	0	0	0	0	1	10356	1422	50	4		4	NEDD4	15	56209012	Silent	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	32277247	56209012	46322380	43	3993										
GLCE	26035	broad.mit.edu	37	chr15	69553589	69553589	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aaaaacaagcctaatgactgGactgtgccaaagggctgctt	10	9	0	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr15:69553589G>C	ENST00000261858.2	+	4	978	c.750G>C	c.(748-750)tgG>tgC	p.W250C	GLCE_ENST00000559500.1_3'UTR|GLCE_ENST00000559420.2_Missense_Mutation_p.W186C	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	250					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						CTAATGACTGGACTGTGCCAA	0.393													17	88					0	0	1	0	0	C	69553589	G	C	69553589	3	2	43	1	0	0	0	0	1	0	0	0	6473	1183	41	2	756	2	GLCE	15	69553589	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	13344577	69553589	32977803	44	3994										
ANKS3	124401	broad.mit.edu	37	chr16	4750876	4750876	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	accgccattctgttctcctaGcagcgcctggcacgtcatat	8	15	3	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr16:4750876G>A	ENST00000450067.2	-	7	1071	c.761C>T	c.(760-762)gCt>gTt	p.A254V	ANKS3_ENST00000446014.2_Intron|ANKS3_ENST00000585773.1_Intron|ANKS3_ENST00000304283.4_Intron			Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	0										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						TGTTCTCCTAGCAGCGCCTGG	0.577													21	136					0	0	1	0	0	A	4750876	G	A	4750876	3	1	43	1	0	0	0	0	1	0	0	0	684	986	34	3		3	ANKS3	16	4750876	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08		4750876	85603877	45	3995										
DCTN5	84516	broad.mit.edu	37	chr16	23654275	23654275	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ttttccgttgttttcttttaGgcatctgggaacaaagtcag	9	7	3	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr16:23654275G>C	ENST00000300087.2	+	2	199		c.e2-1		DCTN5_ENST00000568589.1_Splice_Site|DCTN5_ENST00000568272.1_Splice_Site|DCTN5_ENST00000563998.1_Splice_Site	NM_001199743.1|NM_032486.3	NP_001186672.1|NP_115875.1	Q9BTE1	DCTN5_HUMAN	dynactin 5 (p25)							centrosome	transferase activity			endometrium(2)|lung(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	10				GBM - Glioblastoma multiforme(48;0.0156)		TTTTCTTTTAGGCATCTGGGA	0.443													15	78					0	0	1	0	0	C	23654275	G	C	23654275	5	2	43	1	0	0	0	0	0	0	1	0	4333	1014	35	5	54	5	DCTN5	16	23654275	Splice_Site	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	18903399	23654275	66700478	46	3996										
KIFC3	3801	broad.mit.edu	37	chr16	57795055	57795055	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tcaggttggtgaactcggtcGtgcgattagtgtggccaaac	14	8	1	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr16:57795055G>C	ENST00000379655.4	-	15	2158	c.1901C>G	c.(1900-1902)aCg>aGg	p.T634R	KIFC3_ENST00000562903.1_Missense_Mutation_p.T495R|KIFC3_ENST00000465878.2_Missense_Mutation_p.T495R|KIFC3_ENST00000421376.2_Missense_Mutation_p.T495R|KIFC3_ENST00000539578.1_Missense_Mutation_p.T576R|KIFC3_ENST00000543930.1_Missense_Mutation_p.T492R|KIFC3_ENST00000541240.1_Missense_Mutation_p.T656R|KIFC3_ENST00000445690.2_Missense_Mutation_p.T634R|KIFC3_ENST00000540079.2_Missense_Mutation_p.T532R	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	634	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				GAACTCGGTCGTGCGATTAGT	0.632													11	85					0	0	1	0	0	C	57795055	G	C	57795055	3	2	43	1	0	0	0	0	1	0	0	0	8355	1145	40	5	629	5	KIFC3	16	57795055	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	34140780	57795055	32559698	47	3997										
ANKRD11	29123	broad.mit.edu	37	chr16	89351378	89351378	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gcggcagagctcccgtgagaCgaggtggaggaggcagagag	20	8	0	3			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr16:89351378C>A	ENST00000301030.4	-	9	2032	c.1572G>T	c.(1570-1572)tcG>tcT	p.S524S	ANKRD11_ENST00000378330.2_Silent_p.S524S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	524	Ser-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCCCGTGAGACGAGGTGGAGG	0.622													4	68					0.000602214	0.000622744	1	1	0	A	89351378	C	A	89351378	2	1	43	1	0	0	0	0	0	0	0	1	635	523	19	5		5	ANKRD11	16	89351378	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	31556323	89351378	1003375	48	3998										
TP53	7157	broad.mit.edu	37	chr17	7578265	7578265	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gcaaatttccttccactcggAtaagatgctgaggaggggcc	12	10	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr17:7578265A>G	ENST00000420246.2	-	6	716	c.584T>C	c.(583-585)aTc>aCc	p.I195T	TP53_ENST00000359597.4_Missense_Mutation_p.I195T|TP53_ENST00000269305.4_Missense_Mutation_p.I195T|TP53_ENST00000413465.2_Missense_Mutation_p.I195T|TP53_ENST00000445888.2_Missense_Mutation_p.I195T|TP53_ENST00000455263.2_Missense_Mutation_p.I195T|TP53_ENST00000574684.1_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	195	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		I -> F (in sporadic cancers; somatic mutation).|I -> L (in a sporadic cancer; somatic mutation).|I -> N (in sporadic cancers; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in a sporadic cancer; somatic mutation).|I -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I195T(69)|p.I195N(12)|p.I195S(10)|p.0?(8)|p.I195fs*14(5)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.I102S(2)|p.I102T(2)|p.I63T(2)|p.I63S(2)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.I102fs*14(1)|p.I195fs*12(1)|p.I195fs*50(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I63fs*14(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCCACTCGGATAAGATGCTG	0.552		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	39					0	0	1	0	0	G	7578265	A	G	7578265	3	3	43	1	0	0	0	0	1	0	0	0	16441	333	12	4	710	4	TP53	17	7578265	Missense_Mutation	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08		7578265	73616945	49	3999										
BZRAP1	9256	broad.mit.edu	37	chr17	56386441	56386441	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gctgcttccaccaactaatcCaggcatgtcttccaggcagt	8	14	1	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr17:56386441C>T	ENST00000355701.3	-	22	5062	c.4192G>A	c.(4192-4194)Gga>Aga	p.G1398R	BZRAP1_ENST00000268893.6_Missense_Mutation_p.G1338R|BZRAP1_ENST00000343736.4_Missense_Mutation_p.G1398R	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1398						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCAACTAATCCAGGCATGTCT	0.652													46	104					0	0	1	0	0	T	56386441	C	T	56386441	3	4	43	1	0	0	0	0	1	0	0	0	1580	603	21	3	1421	3	BZRAP1	17	56386441	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	48808176	56386441	24808769	50	4000										
AXIN2	8313	broad.mit.edu	37	chr17	63533589	63533591	+	In_Frame_Del	DEL	TGG	TGG	-													0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ccttggtcttggggacggcaTggtggtggatgtagtggtgg							TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr17:63533589_63533591delTGG	ENST00000307078.5	-	6	1876_1878	c.1563_1565delCCA	c.(1561-1566)cat>ca	p.HH521del	AXIN2_ENST00000375702.5_In_Frame_Del_p.HH521del	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	521					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GGGGACGGCATGGTGGTGGATGT	0.655									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				7	94	---	---	---	---						-	63533591	TGG	-	63533589	7	5	43	1	0	1	0	1	0	0	0	0	1235	1464	51	0	990	0	AXIN2	17	63533589	In_Frame_Del	DEL	TGG	TCGA-NA-A4R0-01A-11D-A28R-08	7147148	63533589	17661621	51	4001										
SMAD4	4089	broad.mit.edu	37	chr18	48573424	48573425	+	Frame_Shift_Del	DEL	AT	AT	-													0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aaaacttgaacaaatggacaAtatgtctattacgaatacac							TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr18:48573424_48573425delAT	ENST00000342988.3	+	2	546_547	c.8_9delAT	c.(7-9)afs	p.N3fs	RP11-729L2.2_ENST00000588256.1_3'UTR|SMAD4_ENST00000452201.2_Frame_Shift_Del_p.N3fs|SMAD4_ENST00000398417.2_Frame_Shift_Del_p.N3fs|RP11-729L2.2_ENST00000590722.2_3'UTR|SMAD4_ENST00000588745.1_Frame_Shift_Del_p.N3fs	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	3					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(5)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CAAATGGACAATATGTCTATTA	0.356													11	20	---	---	---	---						-	48573425	AT	-	48573424	7	5	43	1	0	1	0	1	0	0	0	0	14813	101	4	0	10	0	SMAD4	18	48573424	Frame_Shift_Del	DEL	AT	TCGA-NA-A4R0-01A-11D-A28R-08		48573424	29503824	52	4002										
CILP2	148113	broad.mit.edu	37	chr19	19654969	19654969	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tggacgctgtccgggtcttgCcttttgatcctcgaggtgcc	13	12	1	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr19:19654969C>G	ENST00000586018.1	+	8	1735	c.1633C>G	c.(1633-1635)Cct>Gct	p.P545A	CILP2_ENST00000291495.4_Missense_Mutation_p.P539A			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	539						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity	p.P539S(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CCGGGTCTTGCCTTTTGATCC	0.602													16	90					0	0	1	0	0	G	19654969	C	G	19654969	3	3	43	1	0	0	0	0	1	0	0	0	3452	739	26	5	1645	5	CILP2	19	19654969	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		19654969	39474014	53	4003										
ZNF567	163081	broad.mit.edu	37	chr19	37210154	37210154	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ctgagtactaaacaagagacTactcatcctgaagtcaaatc	6	10	2	3			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr19:37210154T>C	ENST00000585696.1	+	3	1665	c.435T>C	c.(433-435)acT>acC	p.T145T	ZNF567_ENST00000588311.1_Silent_p.T145T|ZNF567_ENST00000536254.2_Silent_p.T176T|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000392163.2_Silent_p.T145T|ZNF567_ENST00000360729.4_Silent_p.T145T			Q8N184	ZN567_HUMAN	zinc finger protein 567	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AACAAGAGACTACTCATCCTG	0.368													12	46					0	0	1	0	0	C	37210154	T	C	37210154	2	2	43	1	0	0	0	0	0	0	0	1	18054	1509	53	4		4	ZNF567	19	37210154	Silent	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	17555185	37210154	21918829	54	4004										
ZNF383	163087	broad.mit.edu	37	chr19	37734477	37734477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	atctgagaattcacactggtGaaaagccctataactgtaag	8	8	2	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr19:37734477G>A	ENST00000589413.1	+	8	1922	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	ZNF383_ENST00000352998.3_Missense_Mutation_p.E447K|ZNF383_ENST00000590503.1_Missense_Mutation_p.E447K			Q8NA42	ZN383_HUMAN	zinc finger protein 383	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)	15			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCACACTGGTGAAAAGCCCTA	0.348													66	54					0	0	1	0	0	A	37734477	G	A	37734477	3	1	43	1	0	0	0	0	1	0	0	0	17930	1291	45	3	1353	3	ZNF383	19	37734477	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	524323	37734477	21394506	55	4005										
SUPT5H	6829	broad.mit.edu	37	chr19	39955456	39955456	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	agcccctgcagatcaagtcaGtagtggcaccagagcatgtg	12	11	2	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr19:39955456G>A	ENST00000599117.1	+	12	1010	c.643G>A	c.(643-645)Gta>Ata	p.V215I	SUPT5H_ENST00000359191.6_Missense_Mutation_p.V211I|SUPT5H_ENST00000598725.1_Missense_Mutation_p.V215I|SUPT5H_ENST00000402194.2_Missense_Mutation_p.V211I|SUPT5H_ENST00000432763.2_Missense_Mutation_p.V215I			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	215	Interaction with SUPT4H1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GATCAAGTCAGTAGTGGCACC	0.572													7	181					0	0	1	0	0	A	39955456	G	A	39955456	3	1	43	1	0	0	0	0	1	0	0	0	15454	1029	36	3	681	3	SUPT5H	19	39955456	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	2220979	39955456	19173527	56	4006										
FCGBP	8857	broad.mit.edu	37	chr19	40374023	40374023	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	gctgtgttcctggcacaccaCgactttacccacatggcacg	9	15	0	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr19:40374023C>T	ENST00000221347.6	-	26	12062	c.12055G>A	c.(12055-12057)Gtg>Atg	p.V4019M		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4019	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCACACCACGACTTTACCC	0.642													4	24					0	0	1	0	0	T	40374023	C	T	40374023	3	4	43	1	0	0	0	0	1	0	0	0	5810	536	19	1	4206	1	FCGBP	19	40374023	Missense_Mutation	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08	418567	40374023	18754960	57	4007										
CYP2F1	1572	broad.mit.edu	37	chr19	41628015	41628015	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ctccccgggacttcatccagTgcttcctcaccaagatggca	8	16	2	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr19:41628015T>A	ENST00000331105.2	+	6	871	c.799T>A	c.(799-801)Tgc>Agc	p.C267S		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	267					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.C267R(2)		central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CTTCATCCAGTGCTTCCTCAC	0.572													15	18					0	0	1	0	0	A	41628015	T	A	41628015	3	1	43	1	0	0	0	0	1	0	0	0	4194	1696	59	4	817	4	CYP2F1	19	41628015	Missense_Mutation	SNP	T	TCGA-NA-A4R0-01A-11D-A28R-08	1253992	41628015	17500968	58	4008										
ARFGEF2	10564	broad.mit.edu	37	chr20	47605195	47605195	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	attgcaaccaaatctactaaGcagagtaaggtctaatggca	8	8	2	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr20:47605195G>A	ENST00000371917.4	+	18	2529	c.2529G>A	c.(2527-2529)aaG>aaA	p.K843K		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	843					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AATCTACTAAGCAGAGTAAGG	0.323													14	64					0	0	1	0	0	A	47605195	G	A	47605195	2	1	43	1	0	0	0	0	0	0	0	1	850	962	34	3		3	ARFGEF2	20	47605195	Silent	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08		47605195	15420325	59	4009										
PHACTR3	116154	broad.mit.edu	37	chr20	58348375	58348375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cctccagcatgaagagtgccGacccttccctccggggccag	11	17	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr20:58348375G>A	ENST00000371015.1	+	6	1260	c.793G>A	c.(793-795)Gac>Aac	p.D265N	PHACTR3_ENST00000541461.1_Missense_Mutation_p.D224N|PHACTR3_ENST00000359926.3_Missense_Mutation_p.D262N|PHACTR3_ENST00000355648.4_Missense_Mutation_p.D224N|PHACTR3_ENST00000395636.2_Missense_Mutation_p.D224N|PHACTR3_ENST00000361300.4_Missense_Mutation_p.D154N|PHACTR3_ENST00000395639.4_Missense_Mutation_p.D154N	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	265						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GAAGAGTGCCGACCCTTCCCT	0.627													5	162					0	0	1	0	0	A	58348375	G	A	58348375	3	1	43	1	0	0	0	0	1	0	0	0	11858	1058	37	1	815	1	PHACTR3	20	58348375	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	10743180	58348375	4677145	60	4010										
PICK1	9463	broad.mit.edu	37	chr22	38470949	38470949	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cgactgctacgcagtgctgcGggatgccgacgtcttcccca	12	15	1	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chr22:38470949G>A	ENST00000404072.3	+	13	1405	c.1058G>A	c.(1057-1059)cGg>cAg	p.R353Q	PICK1_ENST00000356976.3_Missense_Mutation_p.R353Q	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1	353	AH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					GCAGTGCTGCGGGATGCCGAC	0.617													28	36					0	0	1	0	0	A	38470949	G	A	38470949	3	1	43	1	0	0	0	0	1	0	0	0	11928	1116	39	1	1104	1	PICK1	22	38470949	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08		38470949	12833617	61	4011										
WWC3	55841	broad.mit.edu	37	chrX	10066584	10066584	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	acaagacttgtagaccgagtCagacttaattggcaatatga	9	7	1	4			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:10066584C>A	ENST00000380861.4	+	8	1087	c.696C>A	c.(694-696)gtC>gtA	p.V232V	WWC3_ENST00000454666.1_Silent_p.V232V	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	232										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						TAGACCGAGTCAGACTTAATT	0.368													8	26					0.000274275	0.000290221	1	1	0	A	10066584	C	A	10066584	2	1	43	1	0	0	0	0	0	0	0	1	17472	813	29	2		2	WWC3	23	10066584	Silent	SNP	C	TCGA-NA-A4R0-01A-11D-A28R-08		10066584	145203976	62	4012										
HUWE1	10075	broad.mit.edu	37	chrX	53574727	53574727	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cgtggcagcaaccagggctgGagcagaagtgacaggggtgg	19	8	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:53574727G>T	ENST00000342160.3	-	67	11000	c.10543C>A	c.(10543-10545)Cca>Aca	p.P3515T	HUWE1_ENST00000474288.1_5'UTR|HUWE1_ENST00000262854.6_Missense_Mutation_p.P3515T			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3515	Thr-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ACCAGGGCTGGAGCAGAAGTG	0.592													8	29					1.12685e-05	1.22075e-05	1	1	0	T	53574727	G	T	53574727	3	4	43	1	0	0	0	0	1	0	0	0	7504	1174	41	2	2649	2	HUWE1	23	53574727	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	43508143	53574727	101695833	63	4013										
HUWE1	10075	broad.mit.edu	37	chrX	53575115	53575115	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	aataagtcccagaagtctgtGcaaatgccactgctggagga	11	9	1	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:53575115G>A	ENST00000342160.3	-	67	10612	c.10155C>T	c.(10153-10155)tgC>tgT	p.C3385C	HUWE1_ENST00000262854.6_Silent_p.C3385C			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3385					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AGAAGTCTGTGCAAATGCCAC	0.532													5	19					0	0	1	0	0	A	53575115	G	A	53575115	2	1	43	1	0	0	0	0	0	0	0	1	7504	1311	46	3		3	HUWE1	23	53575115	Silent	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	388	53575115	101695445	64	4014										
NXF5	55998	broad.mit.edu	37	chrX	101092527	101092527	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cggtctggtaccacatgtccAccaggatggaggtgaagtca	13	10	2	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:101092527A>T	ENST00000537026.1	-	15	1378	c.1019T>A	c.(1018-1020)gTg>gAg	p.V340E	NXF5_ENST00000473265.2_Missense_Mutation_p.V340E|NXF5_ENST00000361708.2_Missense_Mutation_p.V340E	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	340	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						CCACATGTCCACCAGGATGGA	0.562													51	176					0	0	1	0	0	T	101092527	A	T	101092527	3	4	43	1	0	0	0	0	1	0	0	0	10833	159	6	4	86	4	NXF5	23	101092527	Missense_Mutation	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08	47517412	101092527	54178033	65	4015										
COL4A6	1288	broad.mit.edu	37	chrX	107408631	107408631	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	tctaggcctggtcgcccgggGtcaccaggctgtcctgctat	13	14	2	0			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:107408631G>T	ENST00000394872.2	-	38	4011	c.3780C>A	c.(3778-3780)gaC>gaA	p.D1260E	COL4A6_ENST00000372216.4_Missense_Mutation_p.D1260E|COL4A6_ENST00000334504.7_Missense_Mutation_p.D1259E|COL4A6_ENST00000545689.1_Missense_Mutation_p.D1235E|COL4A6_ENST00000538570.1_Missense_Mutation_p.D1235E			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1260	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						GTCGCCCGGGGTCACCAGGCT	0.557									Alport syndrome with Diffuse Leiomyomatosis				30	126					3.1745e-13	3.75168e-13	1	1	0	T	107408631	G	T	107408631	3	4	43	1	0	0	0	0	1	0	0	0	3718	1252	44	5	1327	5	COL4A6	23	107408631	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	6316104	107408631	47861929	66	4016										
KLHL13	90293	broad.mit.edu	37	chrX	117054245	117054245	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	cactagcagatgccatcatgActctatgcacagggaaagca	9	11	2	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:117054245A>G	ENST00000371876.1	-	2	2597	c.176T>C	c.(175-177)gTc>gCc	p.V59A	KLHL13_ENST00000371882.1_Missense_Mutation_p.V59A|KLHL13_ENST00000469946.1_Missense_Mutation_p.V59A|KLHL13_ENST00000545703.1_Missense_Mutation_p.V68A|KLHL13_ENST00000540167.1_Missense_Mutation_p.V94A|KLHL13_ENST00000262820.3_Missense_Mutation_p.V110A|KLHL13_ENST00000539496.1_Missense_Mutation_p.V113A|KLHL13_ENST00000541812.1_Missense_Mutation_p.V94A|KLHL13_ENST00000371878.1_Missense_Mutation_p.V59A			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	110					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TGCCATCATGACTCTATGCAC	0.418													27	95					0	0	1	0	0	G	117054245	A	G	117054245	3	3	43	1	0	0	0	0	1	0	0	0	8411	275	10	4	1658	4	KLHL13	23	117054245	Missense_Mutation	SNP	A	TCGA-NA-A4R0-01A-11D-A28R-08	9645614	117054245	38216315	67	4017										
RHOXF1	158800	broad.mit.edu	37	chrX	119249749	119249749	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	ctcaggcagtagaacacggtGtcgtggacgagcgaacgcgc	15	11	1	1			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:119249749G>T	ENST00000217999.2	-	1	98	c.24C>A	c.(22-24)gaC>gaA	p.D8E	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	8					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						AGAACACGGTGTCGTGGACGA	0.607													21	77					8.34094e-07	9.14488e-07	1	1	0	T	119249749	G	T	119249749	3	4	43	1	0	0	0	0	1	0	0	0	13396	1368	48	5	542	5	RHOXF1	23	119249749	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	2195504	119249749	36020811	68	4018										
MAGEA11	4110	broad.mit.edu	37	chrX	148798278	148798278	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0869565217391304	6	1	1.42450980392157	1.79382716049383	1.29155555555556	0.619909502262444	1	0	accggcaggtgcccggcactGatcctgcatgctatgagttc	12	13	0	2			TCGA-NA-A4R0-01A-11D-A28R-08	TCGA-NA-A4R0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec89bdc8-d603-4989-a40b-1a113e74c6dd	a8070b85-a83f-4ac4-a7de-05934dc2af36	g.chrX:148798278G>A	ENST00000355220.5	+	5	1234	c.1132G>A	c.(1132-1134)Gat>Aat	p.D378N	MAGEA11_ENST00000333104.4_Missense_Mutation_p.D349N	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	378	MAGE.					cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GCCCGGCACTGATCCTGCATG	0.557													60	227					0	0	1	0	0	A	148798278	G	A	148798278	3	1	43	1	0	0	0	0	1	0	0	0	9210	1290	45	3	1159	3	MAGEA11	23	148798278	Missense_Mutation	SNP	G	TCGA-NA-A4R0-01A-11D-A28R-08	29548529	148798278	6472282	69	4019										
ATAD3C	219293	broad.mit.edu	37	chr1	1391260	1391260	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tacaggcacatcctgctgtaCgggccaccaggcaccgggaa	12	14	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:1391260C>T	ENST00000378785.2	+	6	1523	c.528C>T	c.(526-528)taC>taT	p.Y176Y		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	176							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCCTGCTGTACGGGCCACCAG	0.627													19	31					0	0	1	0	0	T	1391260	C	T	1391260	2	4	44	1	0	0	0	0	0	0	0	1	1074	547	19	1		1	ATAD3C	1	1391260	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		1391260	247859361	1	4020										
SSU72	29101	broad.mit.edu	37	chr1	1500071	1500071	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtgcactgcacagggtgacaCgcctcctgtgcccgagccac	12	16	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:1500071C>T	ENST00000359060.4	-	2	332	c.306G>A	c.(304-306)gcG>gcA	p.A102A	SSU72_ENST00000291386.3_Intron			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CAGGGTGACACGCCTCCTGTG	0.562													53	59					0	0	1	0	0	T	1500071	C	T	1500071	2	4	44	1	0	0	0	0	0	0	0	1	15257	551	19	1		1	SSU72	1	1500071	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	108811	1500071	247750550	2	4021										
GNB1	2782	broad.mit.edu	37	chr1	1747258	1747258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcccccgcagtgtcctcctcGtgcgcatttggattcttccc	9	17	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:1747258G>A	ENST00000378609.4	-	5	471	c.140C>T	c.(139-141)aCg>aTg	p.T47M		NM_002074.3	NP_002065.1	P62873	GBB1_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1	47					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	12	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		TGTCCTCCTCGTGCGCATTTG	0.488													11	29					0	0	1	0	0	A	1747258	G	A	1747258	3	1	44	1	0	0	0	0	1	0	0	0	6556	1145	40	1	910	1	GNB1	1	1747258	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	247187	1747258	247503363	3	4022										
TMEM201	199953	broad.mit.edu	37	chr1	9661177	9661177	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttgcagaacttctcctccgcCgtgaagtccccggtccaggt	10	15	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:9661177C>T	ENST00000340305.5	+	5	630	c.621C>T	c.(619-621)gcC>gcT	p.A207A	TMEM201_ENST00000377376.4_Silent_p.A207A|TMEM201_ENST00000340381.6_Silent_p.A207A	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	207						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		TCTCCTCCGCCGTGAAGTCCC	0.652													37	121					0	0	1	0	0	T	9661177	C	T	9661177	2	4	44	1	0	0	0	0	0	0	0	1	16185	639	23	1		1	TMEM201	1	9661177	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	7913919	9661177	239589444	4	4023										
PADI1	29943	broad.mit.edu	37	chr1	17570624	17570624	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctggagcctctgggcctgcaCtgcatcttcattgatgacta	10	12	3	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:17570624C>T	ENST00000375471.4	+	16	1970	c.1878C>T	c.(1876-1878)caC>caT	p.H626H	PADI1_ENST00000536552.1_Silent_p.H97H|PADI1_ENST00000537499.1_Silent_p.H183H|PADI1_ENST00000460293.1_3'UTR|PADI1_ENST00000413717.2_Silent_p.H141H	NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	626					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	TGGGCCTGCACTGCATCTTCA	0.597													39	38					0	0	1	0	0	T	17570624	C	T	17570624	2	4	44	1	0	0	0	0	0	0	0	1	11423	564	20	3		3	PADI1	1	17570624	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	7909447	17570624	231679997	5	4024										
EPHA8	2046	broad.mit.edu	37	chr1	22928123	22928123	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcacccttccttcacagggaCgtgcgcgccctgggcatcac	11	17	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:22928123C>T	ENST00000166244.3	+	17	2979	c.2907C>T	c.(2905-2907)gaC>gaT	p.D969D		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	969	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTCACAGGGACGTGCGCGCCC	0.697													5	10					0	0	1	0	0	T	22928123	C	T	22928123	2	4	44	1	0	0	0	0	0	0	0	1	5201	535	19	1		1	EPHA8	1	22928123	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	5357499	22928123	226322498	6	4025										
CLIC4	25932	broad.mit.edu	37	chr1	25140694	25140694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttgaggaatttcttgaagaaGtcttatgccctcccaagtga	9	8	2	4			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:25140694G>A	ENST00000374379.4	+	3	489	c.292G>A	c.(292-294)Gtc>Atc	p.V98I	CLIC4_ENST00000497755.1_3'UTR	NM_013943.2	NP_039234.1	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	98	Required for insertion into the membrane (Probable).				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity			large_intestine(3)|lung(2)|skin(1)	6		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		TCTTGAAGAAGTCTTATGCCC	0.403													46	32					0	0	1	0	0	A	25140694	G	A	25140694	3	1	44	1	0	0	0	0	1	0	0	0	3551	1029	36	3	302	3	CLIC4	1	25140694	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	2212571	25140694	224109927	7	4026										
AIM1L	55057	broad.mit.edu	37	chr1	26669268	26669268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gacaaccctccttagggagcCgatgccttggggactccact	11	14	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:26669268C>T	ENST00000527815.1	-	4	608	c.559G>A	c.(559-561)Ggc>Agc	p.G187S	AIM1L_ENST00000308182.5_Missense_Mutation_p.G16S	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	16	Beta/gamma crystallin 'Greek key' 4.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CTTAGGGAGCCGATGCCTTGG	0.597													105	112					0	0	1	0	0	T	26669268	C	T	26669268	3	4	44	1	0	0	0	0	1	0	0	0	428	652	23	1	1868	1	AIM1L	1	26669268	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	1528574	26669268	222581353	8	4027										
GJB3	2707	broad.mit.edu	37	chr1	35250835	35250835	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctctctggcatggcttcaatAtgccgcgcctggtgcagtgt	12	12	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:35250835A>G	ENST00000373366.2	+	2	1087	c.472A>G	c.(472-474)Atg>Gtg	p.M158V	RP1-34M23.5_ENST00000542839.1_RNA|GJB3_ENST00000373362.3_Missense_Mutation_p.M158V	NM_024009.2	NP_076872.1	O75712	CXB3_HUMAN	gap junction protein, beta 3, 31kDa	158					cell communication	connexon complex|integral to membrane	gap junction channel activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|prostate(3)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TGGCTTCAATATGCCGCGCCT	0.552													69	60					0	0	1	0	0	G	35250835	A	G	35250835	3	3	44	1	0	0	0	0	1	0	0	0	6450	449	16	4	474	4	GJB3	1	35250835	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	8581567	35250835	213999786	9	4028										
LRRC41	10489	broad.mit.edu	37	chr1	46751419	46751421	+	In_Frame_Del	DEL	AGA	AGA	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcccgtttgtatgaggatgtAgaagaagaggcagaggaggt							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:46751419_46751421delAGA	ENST00000343304.6	-	4	1393_1395	c.1108_1110delTCT	c.(1108-1110)del	p.S370del	LRRC41_ENST00000472710.1_5'UTR	NM_006369.4	NP_006360.3	Q15345	LRC41_HUMAN	leucine rich repeat containing 41	370										breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					ATGAGGATGTAGAAGAAGAGGCA	0.606													26	122	---	---	---	---						-	46751421	AGA	-	46751419	7	5	44	1	0	1	0	1	0	0	0	0	9043	407	15	0	1356	0	LRRC41	1	46751419	In_Frame_Del	DEL	AGA	TCGA-NA-A4R1-01A-11D-A28R-08	11500584	46751419	202499202	10	4029										
LRRC7	57554	broad.mit.edu	37	chr1	70225900	70225900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcctggagatgaccaccaaaCggaaaatcatcggccgtctg	11	12	2	2	rs150507629		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:70225900C>T	ENST00000310961.5	+	4	446	c.28C>T	c.(28-30)Cgg>Tgg	p.R10W	LRRC7_ENST00000370958.1_Missense_Mutation_p.R43W|LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.R5W			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	5						centrosome|focal adhesion|nucleolus	protein binding	p.R5W(2)|p.R43W(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GACCACCAAACGGAAAATCAT	0.458													21	20					0	0	1	0	0	T	70225900	C	T	70225900	3	4	44	1	0	0	0	0	1	0	0	0	9064	527	19	1	15	1	LRRC7	1	70225900	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	23474481	70225900	179024721	11	4030										
PTBP2	58155	broad.mit.edu	37	chr1	97217025	97217025	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ggcagtgttctcagtagtccGaactctaatatgagcagcat	10	9	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:97217025G>A	ENST00000236228.6	+	3	166	c.84G>A	c.(82-84)ccG>ccA	p.P28P	PTBP2_ENST00000482253.1_Intron|PTBP2_ENST00000426398.2_Silent_p.P28P|PTBP2_ENST00000394184.3_Silent_p.P39P|PTBP2_ENST00000541987.1_5'UTR|PTBP2_ENST00000370198.1_Silent_p.P28P|PTBP2_ENST00000370197.1_Silent_p.P28P	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	28							nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TCAGTAGTCCGAACTCTAATA	0.348													75	76					0	0	1	0	0	A	97217025	G	A	97217025	2	1	44	1	0	0	0	0	0	0	0	1	12774	1045	37	1		1	PTBP2	1	97217025	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	26991125	97217025	152033596	12	4031										
PDE4DIP	9659	broad.mit.edu	37	chr1	145075040	145075040	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctgcatggcctccatccagCcatcaggcagggctccagct	10	17	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:145075040C>A	ENST00000369345.4	-	2	468	c.254G>T	c.(253-255)gGc>gTc	p.G85V	PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000369348.3_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCCATCCAGCCATCAGGCAG	0.502			T	PDGFRB	MPD								6	47					0.00116845	0.00118836	1	1	0	A	145075040	C	A	145075040	3	1	44	1	0	0	0	0	1	0	0	0	11689	754	26	5		5	PDE4DIP	1	145075040	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	47858015	145075040	104175581	13	4032										
INSRR	3645	broad.mit.edu	37	chr1	156823762	156823762	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gctcctggttcttctccacaCgcacagccccacgcagcacg	8	19	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:156823762C>T	ENST00000368195.3	-	2	815	c.419G>A	c.(418-420)cGt>cAt	p.R140H	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	140					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTTCTCCACACGCACAGCCCC	0.627													19	22					0	0	1	0	0	T	156823762	C	T	156823762	3	4	44	1	0	0	0	0	1	0	0	0	7817	536	19	1	3557	1	INSRR	1	156823762	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	11748722	156823762	92426859	14	4033										
TADA1	117143	broad.mit.edu	37	chr1	166829507	166829507	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tgccaaaggcatatttaaaaTgaccatctcgtaaccgataa	6	9	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:166829507T>C	ENST00000367874.4	-	6	701	c.608A>G	c.(607-609)cAt>cGt	p.H203R	TADA1_ENST00000467021.1_5'UTR	NM_053053.3	NP_444281.1	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1	203					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	11						ATATTTAAAATGACCATCTCG	0.358													23	23					0	0	1	0	0	C	166829507	T	C	166829507	3	2	44	1	0	0	0	0	1	0	0	0	15565	1464	51	4	411	4	TADA1	1	166829507	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	10005745	166829507	82421114	15	4034										
PAPPA2	60676	broad.mit.edu	37	chr1	176709279	176709279	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcctcccgcattggtctttcGgctcccagtaactgcatctc	7	16	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:176709279G>A	ENST00000367662.3	+	14	5262	c.4098G>A	c.(4096-4098)tcG>tcA	p.S1366S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1366					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.S1366S(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGGTCTTTCGGCTCCCAGTA	0.507													33	32					0	0	1	0	0	A	176709279	G	A	176709279	2	1	44	1	0	0	0	0	0	0	0	1	11479	1103	39	1		1	PAPPA2	1	176709279	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	9879772	176709279	72541342	16	4035										
NCF2	4688	broad.mit.edu	37	chr1	183532665	183532665	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gctgagtcttcatgactaccGtgtacttgtagtgcaccttg	10	10	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:183532665G>A	ENST00000413720.1	-	11	1221	c.947C>T	c.(946-948)aCg>aTg	p.T316M	NCF2_ENST00000367535.3_Missense_Mutation_p.T361M|NCF2_ENST00000469280.1_5'UTR|NCF2_ENST00000418089.1_Missense_Mutation_p.T280M|NCF2_ENST00000367536.1_Missense_Mutation_p.T361M	NM_001190794.1	NP_001177723.1	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	361					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30						CATGACTACCGTGTACTTGTA	0.547													69	85					0	0	1	0	0	A	183532665	G	A	183532665	3	1	44	1	0	0	0	0	1	0	0	0	10263	1145	40	1	514	1	NCF2	1	183532665	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	6823386	183532665	65717956	17	4036										
FAM5C	0	broad.mit.edu	37	chr1	190067975	190067975	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tttcatctcgagatcttgcaGgtcagtttcaaagccaatat	7	9	5	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:190067975G>A	ENST00000367462.3	-	8	1705	c.1474C>T	c.(1474-1476)Ctg>Ttg	p.L492L	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.L390L	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		492						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGATCTTGCAGGTCAGTTTCA	0.512													29	136					0	0	1	0	0	A	190067975	G	A	190067975	2	1	44	1	0	0	0	0	0	0	0	1	5628	991	35	3		3	FAM5C	1	190067975	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	6535310	190067975	59182646	18	4037										
RASSF5	83593	broad.mit.edu	37	chr1	206711576	206711576	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcagcaggagggtttatcccGggacagaccctctccagaaa	11	12	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:206711576G>A	ENST00000338603.2	+	2	590	c.533G>A	c.(532-534)cGg>cAg	p.R178Q	RASSF5_ENST00000367117.3_Missense_Mutation_p.R178Q|RASSF5_ENST00000355294.4_Missense_Mutation_p.R178Q	NM_182663.2	NP_872604.1	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family member 5	178					apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	8	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GGTTTATCCCGGGACAGACCC	0.567													134	87					0	0	1	0	0	A	206711576	G	A	206711576	3	1	44	1	0	0	0	0	1	0	0	0	13140	1116	39	1	539	1	RASSF5	1	206711576	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	16643601	206711576	42539045	19	4038										
NSL1	25936	broad.mit.edu	37	chr1	212964879	212964879	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	actggtcccgtacccactgcGcatctcgcagagcgggctcc	11	17	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:212964879G>A	ENST00000366977.3	-	1	245	c.227C>T	c.(226-228)gCg>gTg	p.A76V	NSL1_ENST00000473995.1_5'UTR|NSL1_ENST00000366975.6_Missense_Mutation_p.A76V|NSL1_ENST00000422588.2_Missense_Mutation_p.A76V|NSL1_ENST00000366976.1_Missense_Mutation_p.A76V|NSL1_ENST00000366978.1_5'UTR	NM_015471.3	NP_056286.3	Q96IY1	NSL1_HUMAN	NSL1, MIS12 kinetochore complex component	76					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		TACCCACTGCGCATCTCGCAG	0.582													5	236					0	0	1	0	0	A	212964879	G	A	212964879	3	1	44	1	0	0	0	0	1	0	0	0	10720	1087	38	1	731	1	NSL1	1	212964879	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	6253303	212964879	36285742	20	4039										
OBSCN	84033	broad.mit.edu	37	chr1	228547520	228547520	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctgtatgtgacggaggccgaGgcccactctccagctctgcc	12	15	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:228547520G>A	ENST00000284548.11	+	81	19001	c.18927G>A	c.(18925-18927)gaG>gaA	p.E6309E	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366709.4_Silent_p.E3428E|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000570156.2_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7132					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGGAGGCCGAGGCCCACTCTC	0.682													5	11					0	0	1	0	0	A	228547520	G	A	228547520	2	1	44	1	0	0	0	0	0	0	0	1	10859	991	35	3		3	OBSCN	1	228547520	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	15582641	228547520	20703101	21	4040										
CYP1B1	1545	broad.mit.edu	37	chr2	38301893	38301893	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcggggtcgtcgtggctgtaGcggcagccgaaacacacggc	16	12	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:38301893G>A	ENST00000260630.3	-	2	1040	c.639C>T	c.(637-639)cgC>cgT	p.R213R	CYP1B1_ENST00000494864.1_Intron|CYP1B1_ENST00000407341.1_Silent_p.R213R	NM_000104.3	NP_000095.2	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B, polypeptide 1	213					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	13		all_hematologic(82;0.21)			Estrone(DB00655)	CGTGGCTGTAGCGGCAGCCGA	0.701													4	14					0	0	1	0	0	A	38301893	G	A	38301893	2	1	44	1	0	0	0	0	0	0	0	1	4174	958	34	3		3	CYP1B1	2	38301893	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		38301893	204897480	22	4041										
LHCGR	3973	broad.mit.edu	37	chr2	48925846	48925846	+	Frame_Shift_Del	DEL	T	T	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aatgtttctcttgatggcaaTttttttagagaataggatga							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:48925846delT	ENST00000294954.7	-	9	795	c.774delA	c.(772-774)aafs	p.K258fs	LHCGR_ENST00000405626.1_Frame_Shift_Del_p.K258fs|LHCGR_ENST00000403273.1_Frame_Shift_Del_p.K258fs|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000401907.1_Frame_Shift_Del_p.K258fs|LHCGR_ENST00000344775.3_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	258					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TTGATGGCAATTTTTTTAGAG	0.453													14	42	---	---	---	---						-	48925846	T	-	48925846	7	5	44	1	0	1	0	1	0	0	0	0	8801	1490	52	0	1337	0	LHCGR	2	48925846	Frame_Shift_Del	DEL	T	TCGA-NA-A4R1-01A-11D-A28R-08	10623953	48925846	194273527	23	4042										
NRXN1	9378	broad.mit.edu	37	chr2	51254739	51254739	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tccgttgaggcacaccccgcCctcgccctcctcgcccgcct	8	23	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:51254739C>A	ENST00000404971.1	-	2	2012	c.673G>T	c.(673-675)Ggc>Tgc	p.G225C	NRXN1_ENST00000405472.3_Missense_Mutation_p.G225C|NRXN1_ENST00000401669.2_Missense_Mutation_p.G225C|NRXN1_ENST00000402717.3_Missense_Mutation_p.G225C|NRXN1_ENST00000406859.3_Missense_Mutation_p.G225C|NRXN1_ENST00000405581.1_Missense_Mutation_p.G225C|NRXN1_ENST00000406316.2_Missense_Mutation_p.G225C	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	225	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CACACCCCGCCCTCGCCCTCC	0.716													7	8					0.00198382	0.00200623	1	1	0	A	51254739	C	A	51254739	3	1	44	1	0	0	0	0	1	0	0	0	10712	623	22	5	4325	5	NRXN1	2	51254739	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	2328893	51254739	191944634	24	4043										
TEKT4	150483	broad.mit.edu	37	chr2	95537621	95537621	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gagcgactgcaggacacgcaCagctggaagtcggagctgca	15	11	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:95537621C>T	ENST00000295201.4	+	1	434	c.297C>T	c.(295-297)caC>caT	p.H99H	AC097374.2_ENST00000568768.1_RNA|TEKT4_ENST00000427593.2_Silent_p.H99H	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	99					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						AGGACACGCACAGCTGGAAGT	0.687													3	16					0	0	1	0	0	T	95537621	C	T	95537621	2	4	44	1	0	0	0	0	0	0	0	1	15813	477	17	3		3	TEKT4	2	95537621	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	44282882	95537621	147661752	25	4044										
PTPN18	26469	broad.mit.edu	37	chr2	131116491	131116491	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctgacggcgtgtgctccaccGtggccggcagtcggccagag	16	14	0	2	rs11892325	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:131116491G>A	ENST00000175756.5	+	2	246	c.145G>A	c.(145-147)Gtg>Atg	p.V49M	PTPN18_ENST00000347849.3_Intron|PTPN18_ENST00000420717.1_3'UTR	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	49	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					GTGCTCCACCGTGGCCGGCAG	0.627													44	68					0	0	1	0	0	A	131116491	G	A	131116491	3	1	44	1	0	0	0	0	1	0	0	0	12833	1145	40	1	151	1	PTPN18	2	131116491	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	35578870	131116491	112082882	26	4045										
KYNU	8942	broad.mit.edu	37	chr2	143718291	143718291	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agtggggtgcatttttacacTggacagcactttaatattcc	9	8	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:143718291T>C	ENST00000264170.4	+	8	939	c.681T>C	c.(679-681)acT>acC	p.T227T	KYNU_ENST00000409512.1_Silent_p.T227T|KYNU_ENST00000375773.2_Silent_p.T227T	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	227					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ATTTTTACACTGGACAGCACT	0.428													14	56					0	0	1	0	0	C	143718291	T	C	143718291	2	2	44	1	0	0	0	0	0	0	0	1	8625	1567	55	4		4	KYNU	2	143718291	Silent	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	12601800	143718291	99481082	27	4046										
NEUROD1	4760	broad.mit.edu	37	chr2	182543459	182543459	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcctctgcgttcatggtttcGaggtcgtcctccttcttgtc	9	13	3	0	rs116321775	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:182543459G>A	ENST00000295108.3	-	2	586	c.129C>T	c.(127-129)ctC>ctT	p.L43L	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	43					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCATGGTTTCGAGGTCGTCCT	0.582													28	15					0	0	1	0	0	A	182543459	G	A	182543459	2	1	44	1	0	0	0	0	0	0	0	1	10394	1045	37	1		1	NEUROD1	2	182543459	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	38825168	182543459	60655914	28	4047										
SH3BP4	23677	broad.mit.edu	37	chr2	235950972	235950972	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	acccaaccctgccccggtggCcctgcagctgtgggggaagc	14	16	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:235950972C>T	ENST00000409212.1	+	4	2066	c.1559C>T	c.(1558-1560)gCc>gTc	p.A520V	SH3BP4_ENST00000344528.4_Missense_Mutation_p.A520V|SH3BP4_ENST00000392011.2_Missense_Mutation_p.A520V			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	520					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GCCCCGGTGGCCCTGCAGCTG	0.567													12	47					0	0	1	0	0	T	235950972	C	T	235950972	3	4	44	1	0	0	0	0	1	0	0	0	14299	739	26	3	1565	3	SH3BP4	2	235950972	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	53407513	235950972	7248401	29	4048										
PASK	23178	broad.mit.edu	37	chr2	242078093	242078093	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctctggaaagcgacccaggtCgagaccctctccacgggctc	11	16	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:242078093C>T	ENST00000403638.3	-	5	808	c.717G>A	c.(715-717)tcG>tcA	p.S239S	PASK_ENST00000539818.1_Silent_p.S23S|PASK_ENST00000405260.1_Silent_p.S239S|PASK_ENST00000544142.1_Silent_p.S53S|PASK_ENST00000234040.4_Silent_p.S239S|PASK_ENST00000358649.4_Silent_p.S239S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	239					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CGACCCAGGTCGAGACCCTCT	0.602													32	50					0	0	1	0	0	T	242078093	C	T	242078093	2	4	44	1	0	0	0	0	0	0	0	1	11518	871	31	1		1	PASK	2	242078093	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	6127121	242078093	1121280	30	4049										
DLEC1	9940	broad.mit.edu	37	chr3	38139340	38139340	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ggaacgtcagccagctcccaGccacatggcgcatgaaggag	13	13	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:38139340G>A	ENST00000308059.6	+	18	2692	c.2671G>A	c.(2671-2673)Gcc>Acc	p.A891T	DLEC1_ENST00000452631.2_Missense_Mutation_p.A891T|DLEC1_ENST00000346219.3_Missense_Mutation_p.A891T			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	891					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCAGCTCCCAGCCACATGGCG	0.597													37	0					0	0	1	0	0	A	38139340	G	A	38139340	3	1	44	1	0	0	0	0	1	0	0	0	4580	971	34	3	2741	3	DLEC1	3	38139340	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		38139340	159883090	31	4050										
MAGI1	9223	broad.mit.edu	37	chr3	65342632	65342632	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttgggttgtctgctatactcTctgctgcctttcggatccct	9	12	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:65342632T>C	ENST00000402939.2	-	23	3809	c.3810A>G	c.(3808-3810)agA>agG	p.R1270R	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1299					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TGCTATACTCTCTGCTGCCTT	0.587													31	83					0	0	1	0	0	C	65342632	T	C	65342632	2	2	44	1	0	0	0	0	0	0	0	1	9239	1548	54	4		4	MAGI1	3	65342632	Silent	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	27203292	65342632	132679798	32	4051										
TMF1	7110	broad.mit.edu	37	chr3	69093748	69093748	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cattcagaaattcaactgtcTggataaggcgaatacataaa	7	7	3	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:69093748T>C	ENST00000543976.1	-	3	1603		c.e3-2		CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA|TMF1_ENST00000398559.2_Splice_Site|CTD-2013N24.2_ENST00000596274.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000601735.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TTCAACTGTCTGGATAAGGCG	0.348													6	19					0	0	1	0	0	C	69093748	T	C	69093748	5	2	44	1	0	0	0	0	0	0	1	0	16287	1594	55	4	1995	4	TMF1	3	69093748	Splice_Site	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	3751116	69093748	128928682	33	4052										
KALRN	8997	broad.mit.edu	37	chr3	124157839	124157840	+	Frame_Shift_Ins	INS	-	-	C													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cagagatcgaccatgtcattINScccctcatcagcaaacattt							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:124157839_124157840insC	ENST00000360013.3	+	18	3274_3275	c.3147_3148insC	c.(3145-3150)atccctfs	p.IP1049fs	KALRN_ENST00000240874.3_Frame_Shift_Ins_p.IP1049fs|KALRN_ENST00000460856.1_Frame_Shift_Ins_p.IP1040fs	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1049					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						ACCATGTCATTCCCCTCATCAG	0.525													24	27	---	---	---	---						C	124157840	-	C	124157839	7	5	44	1	0	1	1	0	0	0	0	0	8018	1771	62	0	3217	0	KALRN	3	124157839	Frame_Shift_Ins	INS	-	TCGA-NA-A4R1-01A-11D-A28R-08	55064091	124157839	73864591	34	4053										
HTR3E	285242	broad.mit.edu	37	chr3	183818194	183818194	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttttatcacgggcgaccccaCgccctgccttggggcccctc	10	18	1	0	rs142990158	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:183818194C>T	ENST00000335304.2	+	1	228	c.34C>T	c.(34-36)Cgc>Tgc	p.R12C	HTR3E_ENST00000440596.2_Missense_Mutation_p.R12C|HTR3E_ENST00000415389.2_Intron|HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000436361.2_Missense_Mutation_p.R12C|HTR3E_ENST00000425359.2_Intron	NM_182589.2|NM_198314.2	NP_872395.2|NP_938056.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	0						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GGCGACCCCACGCCCTGCCTT	0.478													50	58					0	0	1	0	0	T	183818194	C	T	183818194	3	4	44	1	0	0	0	0	1	0	0	0	7491	536	19	1	36	1	HTR3E	3	183818194	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	59660355	183818194	14204236	35	4054										
LPP	4026	broad.mit.edu	37	chr3	188590444	188590444	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctttcaggaaatttgccccgCgatgttctgtgtgcaaggag	12	9	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:188590444C>T	ENST00000312675.4	+	10	1849	c.1603C>T	c.(1603-1605)Cga>Tga	p.R535*	LPP_ENST00000543006.1_Nonsense_Mutation_p.R535*	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	535	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		ATTTGCCCCGCGATGTTCTGT	0.527			T	"HMGA2, MLL, C12orf9"	"lipoma, leukemia"								46	2					0	0	1	0	0	T	188590444	C	T	188590444	4	4	44	1	0	0	0	0	0	1	0	0	8967	760	27	1	1633	1	LPP	3	188590444	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	4772250	188590444	9431986	36	4055										
SORCS2	57537	broad.mit.edu	37	chr4	7725501	7725501	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tacgtgaaccttacactgacCggggagcccatccggcaccg	11	15	0	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:7725501C>T	ENST00000507866.2	+	19	2611	c.2502C>T	c.(2500-2502)acC>acT	p.T834T	SORCS2_ENST00000329016.9_Silent_p.T662T	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	834	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						TTACACTGACCGGGGAGCCCA	0.612													32	4					0	0	1	0	0	T	7725501	C	T	7725501	2	4	44	1	0	0	0	0	0	0	0	1	14984	639	23	1		1	SORCS2	4	7725501	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		7725501	183428775	37	4056										
SULT1B1	27284	broad.mit.edu	37	chr4	70620807	70620807	+	Frame_Shift_Del	DEL	T	T	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctgatttaggataagtggcTatcacaatgtcatctggtct							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:70620807delT	ENST00000310613.2	-	2	426	c.129delA	c.(127-129)atfs	p.I43fs		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	43					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						GATAAGTGGCTATCACAATGT	0.408													64	49	---	---	---	---						-	70620807	T	-	70620807	7	5	44	1	0	1	0	1	0	0	0	0	15431	1512	53	0	789	0	SULT1B1	4	70620807	Frame_Shift_Del	DEL	T	TCGA-NA-A4R1-01A-11D-A28R-08	62895306	70620807	120533469	38	4057										
METTL14	57721	broad.mit.edu	37	chr4	119621741	119621741	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttgatgagattgcagcacctCgatcatttatttttctctgg	8	8	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:119621741C>T	ENST00000388822.4	+	8	849	c.682C>T	c.(682-684)Cga>Tga	p.R228*	METTL14_ENST00000506780.1_Nonsense_Mutation_p.R190*			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	228						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						TGCAGCACCTCGATCATTTAT	0.338													24	31					0	0	1	0	0	T	119621741	C	T	119621741	4	4	44	1	0	0	0	0	0	1	0	0	9547	876	31	1	712	1	METTL14	4	119621741	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	49000934	119621741	71532535	39	4058										
FGB	2244	broad.mit.edu	37	chr4	155487137	155487137	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atgctggaggctgtcttcacGctgacccagacctggtgggt	14	11	2	2	rs121909620		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:155487137G>A	ENST00000302068.4	+	2	355	c.292G>A	c.(292-294)Gct>Act	p.A98T	FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	98			A -> T (in Naples and Milano-2; associated with defective thrombin binding and thrombophilia).|Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CTGTCTTCACGCTGACCCAGA	0.537													26	25					0	0	1	0	0	A	155487137	G	A	155487137	3	1	44	1	0	0	0	0	1	0	0	0	5863	1087	38	1	298	1	FGB	4	155487137	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	35865396	155487137	35667139	40	4059										
FAT1	2195	broad.mit.edu	37	chr4	187509884	187509884	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gacacgtcagagcaggaggcGgtggaggcgtacacagacat	16	9	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:187509884G>A	ENST00000441802.2	-	27	13838	c.13629C>T	c.(13627-13629)acC>acT	p.T4543T		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4543					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGCAGGAGGCGGTGGAGGCGT	0.597										HNSCC(5;0.00058)			14	1					0	0	1	0	0	A	187509884	G	A	187509884	2	1	44	1	0	0	0	0	0	0	0	1	5721	1103	39	1		1	FAT1	4	187509884	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	32022747	187509884	3644392	41	4060										
PAPD7	11044	broad.mit.edu	37	chr5	6742670	6742670	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	catcagctttaacatggagaCgggcgtccgggcagcggagt	15	10	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:6742670C>T	ENST00000230859.6	+	5	455	c.326C>T	c.(325-327)aCg>aTg	p.T109M		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	109					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AACATGGAGACGGGCGTCCGG	0.468													26	22					0	0	1	0	0	T	6742670	C	T	6742670	3	4	44	1	0	0	0	0	1	0	0	0	11472	536	19	1	340	1	PAPD7	5	6742670	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		6742670	174172590	42	4061										
CTNND2	1501	broad.mit.edu	37	chr5	10981913	10981913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtttgatgtcttcagcgggcGcaccataagaattcctatac	9	10	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:10981913G>A	ENST00000304623.8	-	21	3578	c.3389C>T	c.(3388-3390)gCg>gTg	p.A1130V	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.A793V|CTNND2_ENST00000511377.1_Missense_Mutation_p.A1039V|CTNND2_ENST00000359640.2_Missense_Mutation_p.A1072V|CTNND2_ENST00000458100.2_Missense_Mutation_p.A697V	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1130					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TTCAGCGGGCGCACCATAAGA	0.343													21	57					0	0	1	0	0	A	10981913	G	A	10981913	3	1	44	1	0	0	0	0	1	0	0	0	4044	1087	38	1	296	1	CTNND2	5	10981913	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	4239243	10981913	169933347	43	4062										
CHD1	1105	broad.mit.edu	37	chr5	98192247	98192247	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agtctgagtgatacctataaTccctggaagatttatggtgc	10	7	1	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:98192247T>C	ENST00000284049.3	-	35	5119	c.4970A>G	c.(4969-4971)gAt>gGt	p.D1657G		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1657					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATACCTATAATCCCTGGAAGA	0.458													12	27					0	0	1	0	0	C	98192247	T	C	98192247	3	2	44	1	0	0	0	0	1	0	0	0	3345	1435	50	4	166	4	CHD1	5	98192247	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	87210334	98192247	82723013	44	4063										
C5orf15	56951	broad.mit.edu	37	chr5	133292586	133292586	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttggtaatcttcaaagaaggCattgcctcattaacattctg	7	8	4	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:133292586C>T	ENST00000231512.3	-	3	964	c.762G>A	c.(760-762)atG>atA	p.M254I		NM_020199.2	NP_064584.1	Q8NC54	KCT2_HUMAN	chromosome 5 open reading frame 15	254						integral to membrane				endometrium(2)|large_intestine(1)|lung(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TCAAAGAAGGCATTGCCTCAT	0.338													11	52					0	0	1	0	0	T	133292586	C	T	133292586	3	4	44	1	0	0	0	0	1	0	0	0	2298	710	25	3	39	3	C5orf15	5	133292586	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	35100339	133292586	47622674	45	4064										
SIL1	64374	broad.mit.edu	37	chr5	138456752	138456752	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agggcctgccactcatgcgtCgggtggaacacctccaggac	13	14	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:138456752C>T	ENST00000394817.2	-	3	355	c.216G>A	c.(214-216)ccG>ccA	p.P72P	SIL1_ENST00000265195.5_Silent_p.P72P|SIL1_ENST00000509534.1_Silent_p.P79P	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor	72	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACTCATGCGTCGGGTGGAACA	0.547									Marinesco-Sjgren syndrome				81	50					0	0	1	0	0	T	138456752	C	T	138456752	2	4	44	1	0	0	0	0	0	0	0	1	14375	871	31	1		1	SIL1	5	138456752	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	5164166	138456752	42458508	46	4065										
CD14	929	broad.mit.edu	37	chr5	140011859	140011859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtgcggcgcacacgcctgtgGgcgtctccattcctgtgttg	14	13	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:140011859G>A	ENST00000302014.6	-	2	1339	c.710C>T	c.(709-711)cCc>cTc	p.P237L	CD14_ENST00000401743.2_Missense_Mutation_p.P237L	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	237					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGCCTGTGGGCGTCTCCAT	0.657													22	76					0	0	1	0	0	A	140011859	G	A	140011859	3	1	44	1	0	0	0	0	1	0	0	0	2986	1232	43	3	421	3	CD14	5	140011859	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	1555107	140011859	40903401	47	4066										
PCDHA6	0	broad.mit.edu	37	chr5	140209479	140209479	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cgcgcagttgacgccgactcAggctacaacgcgtggctttc	12	14	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:140209479A>G	ENST00000529310.1	+	1	1917	c.1803A>G	c.(1801-1803)tcA>tcG	p.S601S	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCGACTCAGGCTACAACG	0.662													5	215					0	0	1	0	0	G	140209479	A	G	140209479	2	3	44	1	0	0	0	0	0	0	0	1	11574	175	7	4		4	PCDHA6	5	140209479	Silent	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	197620	140209479	40705781	48	4067										
PCDHB5	0	broad.mit.edu	37	chr5	140515250	140515250	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aaagagctcttgcagcttgaTataaagaccggcaatttgct	9	8	1	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:140515250T>A	ENST00000231134.5	+	1	451	c.234T>A	c.(232-234)gaT>gaA	p.D78E		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		78	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAGCTTGATATAAAGACCG	0.502													37	59					0	0	1	0	0	A	140515250	T	A	140515250	3	1	44	1	0	0	0	0	1	0	0	0	11591	1403	49	4	236	4	PCDHB5	5	140515250	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	305771	140515250	40400010	49	4068										
NSD1	64324	broad.mit.edu	37	chr5	176721178	176721178	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gctctccaaaaaagctctggCagggacttgtcagaggccat	11	11	3	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:176721178C>A	ENST00000439151.2	+	23	6854	c.6809C>A	c.(6808-6810)gCa>gAa	p.A2270E	NSD1_ENST00000347982.4_Missense_Mutation_p.A2001E|NSD1_ENST00000361032.4_Missense_Mutation_p.A2167E|NSD1_ENST00000354179.4_Missense_Mutation_p.A2001E	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2270	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AAAGCTCTGGCAGGGACTTGT	0.532			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			104	109					1.53058e-52	1.7017e-52	1	1	0	A	176721178	C	A	176721178	3	1	44	1	0	0	0	0	1	0	0	0	10716	710	25	5	6895	5	NSD1	5	176721178	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	36205928	176721178	4194082	50	4069										
SLC25A27	9481	broad.mit.edu	37	chr6	46623609	46623609	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ccctggatctcacaaaaactCgactccaaatgcaaggagaa	7	12	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:46623609C>T	ENST00000371347.5	+	2	388	c.136C>T	c.(136-138)Cga>Tga	p.R46*	SLC25A27_ENST00000452689.2_5'UTR|SLC25A27_ENST00000411689.2_Nonsense_Mutation_p.R46*	NM_001204051.1|NM_004277.4	NP_001190980.1|NP_004268.3	O95847	UCP4_HUMAN	solute carrier family 25, member 27	46					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane				central_nervous_system(1)|kidney(1)|lung(4)|prostate(1)|urinary_tract(1)	8			Lung(136;0.192)			CACAAAAACTCGACTCCAAAT	0.458													31	32					0	0	1	0	0	T	46623609	C	T	46623609	4	4	44	1	0	0	0	0	0	1	0	0	14544	876	31	1	142	1	SLC25A27	6	46623609	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		46623609	124491458	51	4070										
TULP4	56995	broad.mit.edu	37	chr6	158900985	158900985	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctctgctcctacctctccaCtgccttcatccccaccatca	2	22	4	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:158900985C>T	ENST00000367097.3	+	7	2586	c.1229C>T	c.(1228-1230)aCt>aTt	p.T410I	TULP4_ENST00000367094.2_Missense_Mutation_p.T410I	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	410	SOCS box.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TACCTCTCCACTGCCTTCATC	0.637													11	31					0	0	1	0	0	T	158900985	C	T	158900985	3	4	44	1	0	0	0	0	1	0	0	0	16837	565	20	3	1255	3	TULP4	6	158900985	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	112277376	158900985	12214082	52	4071										
TULP4	56995	broad.mit.edu	37	chr6	158923254	158923254	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	acagcagcacccccgcccccTctgccgcccccacagccccc	6	27	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:158923254T>C	ENST00000367097.3	+	13	3916	c.2559T>C	c.(2557-2559)ccT>ccC	p.P853P	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	853					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCCCGCCCCCTCTGCCGCCCC	0.652													3	8					0	0	1	0	0	C	158923254	T	C	158923254	2	2	44	1	0	0	0	0	0	0	0	1	16837	1538	54	4		4	TULP4	6	158923254	Silent	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	22269	158923254	12191813	53	4072										
NUDCD3	23386	broad.mit.edu	37	chr7	44530146	44530146	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcctggacgttgcccacgtgCtgcaggatgcccaaaagggc	13	13	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:44530146C>T	ENST00000355451.6	-	1	333	c.54G>A	c.(52-54)caG>caA	p.Q18Q		NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	18										endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						TGCCCACGTGCTGCAGGATGC	0.622													15	6					0	0	1	0	0	T	44530146	C	T	44530146	2	4	44	1	0	0	0	0	0	0	0	1	10771	796	28	3		3	NUDCD3	7	44530146	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		44530146	114608517	54	4073										
BAZ1B	9031	broad.mit.edu	37	chr7	72907249	72907249	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tggcgatctacgtgctctgtCatctagtcaaatcatagaaa	8	9	6	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:72907249C>T	ENST00000339594.4	-	5	912	c.574G>A	c.(574-576)Gac>Aac	p.D192N	BAZ1B_ENST00000404251.1_Missense_Mutation_p.D192N	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	192	Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CGTGCTCTGTCATCTAGTCAA	0.348													23	10					0	0	1	0	0	T	72907249	C	T	72907249	3	4	44	1	0	0	0	0	1	0	0	0	1328	826	29	3	3937	3	BAZ1B	7	72907249	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	28377103	72907249	86231414	55	4074										
ZNF804B	219578	broad.mit.edu	37	chr7	88963258	88963258	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agaagattcaattggcattcAtgcttcattctctaaatcta	5	8	5	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:88963258A>G	ENST00000333190.4	+	4	1571	c.962A>G	c.(961-963)cAt>cGt	p.H321R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	321						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATTGGCATTCATGCTTCATTC	0.328										HNSCC(36;0.09)			14	32					0	0	1	0	0	G	88963258	A	G	88963258	3	3	44	1	0	0	0	0	1	0	0	0	18219	217	8	4	976	4	ZNF804B	7	88963258	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	16056009	88963258	70175405	56	4075										
AKAP9	10142	broad.mit.edu	37	chr7	91714219	91714219	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aaggccgaggagaagaaagtGaaagtgcaacagattccttt	12	6	0	4			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:91714219G>A	ENST00000359028.2	+	35	9034	c.8809G>A	c.(8809-8811)Gaa>Aaa	p.E2937K	AKAP9_ENST00000358100.2_Intron|AKAP9_ENST00000356239.3_Missense_Mutation_p.E2933K			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2937					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAAGAAAGTGAAAGTGCAAC	0.368			T	BRAF	papillary thyroid								51	106					0	0	1	0	0	A	91714219	G	A	91714219	3	1	44	1	0	0	0	0	1	0	0	0	456	1291	45	3	8935	3	AKAP9	7	91714219	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	2750961	91714219	67424444	57	4076										
ANKIB1	54467	broad.mit.edu	37	chr7	91936913	91936914	+	Frame_Shift_Ins	INS	-	-	A													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctattgatgctgttgataacINSaaaaaaaacacacccttgca							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:91936913_91936914insA	ENST00000265742.3	+	3	805_806	c.429_430insA	c.(427-432)aaaaaafs	p.KK143fs		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	143							protein binding|zinc ion binding	p.N146fs*12(2)		cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGTTGATAACAAAAAAAACAC	0.361													17	46	---	---	---	---						A	91936914	-	A	91936913	7	5	44	1	0	1	1	0	0	0	0	0	626	477	17	0	435	0	ANKIB1	7	91936913	Frame_Shift_Ins	INS	-	TCGA-NA-A4R1-01A-11D-A28R-08	222694	91936913	67201750	58	4077										
TRRAP	8295	broad.mit.edu	37	chr7	98581955	98581955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gctacctccagctggcaggcGtcatgggcaaaaacgagtgc	13	12	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:98581955G>A	ENST00000359863.4	+	60	9483	c.9274G>A	c.(9274-9276)Gtc>Atc	p.V3092I	TRRAP_ENST00000446306.3_Missense_Mutation_p.V3063I|TRRAP_ENST00000355540.3_Missense_Mutation_p.V3063I	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3092	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCTGGCAGGCGTCATGGGCAA	0.498													54	126					0	0	1	0	0	A	98581955	G	A	98581955	3	1	44	1	0	0	0	0	1	0	0	0	16661	1145	40	1	9417	1	TRRAP	7	98581955	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	6645042	98581955	60556708	59	4078										
SLC26A3	1811	broad.mit.edu	37	chr7	107417136	107417136	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gttcttccaatattagccagCgtgctgcattttggactgta	9	9	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:107417136C>T	ENST00000340010.5	-	14	1714	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	SLC26A3_ENST00000422236.2_Silent_p.T475T	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	510					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TATTAGCCAGCGTGCTGCATT	0.333													5	71					0	0	1	0	0	T	107417136	C	T	107417136	2	4	44	1	0	0	0	0	0	0	0	1	14572	755	27	1		1	SLC26A3	7	107417136	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	8835181	107417136	51721527	60	4079										
MDFIC	29969	broad.mit.edu	37	chr7	114562639	114562641	+	In_Frame_Del	DEL	GAG	GAG	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gctaactttccggggcggaaGaggaggaggaggaggaggaa							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:114562639_114562641delGAG	ENST00000257724.3	+	1	431_433	c.168_170delGAG	c.(166-171)aag>aa	p.KR56del	MDFIC_ENST00000448022.1_5'UTR|MDFIC_ENST00000393486.1_5'UTR			Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	0					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						CGGGGCggaagaggaggaggagg	0.709											OREG0003787	type=REGULATORY REGION|Gene=MDFIC|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	2	4	---	---	---	---						-	114562641	GAG	-	114562639	7	5	44	1	0	1	0	1	0	0	0	0	9454	933	33	0	170	0	MDFIC	7	114562639	In_Frame_Del	DEL	GAG	TCGA-NA-A4R1-01A-11D-A28R-08	7145503	114562639	44576024	61	4080										
NUP205	23165	broad.mit.edu	37	chr7	135304341	135304341	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gatagttgcttcacctcaccTcctcctgaagagaacccatt	6	14	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:135304341T>C	ENST00000285968.6	+	29	4160	c.4134T>C	c.(4132-4134)ccT>ccC	p.P1378P		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1378					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TCACCTCACCTCCTCCTGAAG	0.438													7	51					0	0	1	0	0	C	135304341	T	C	135304341	2	2	44	1	0	0	0	0	0	0	0	1	10806	1538	54	4		4	NUP205	7	135304341	Silent	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	20741702	135304341	23834322	62	4081										
OR2A14	135941	broad.mit.edu	37	chr7	143826872	143826872	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctacttgcgcatcctggccGccatcttgaggatccagtct	9	15	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:143826872G>A	ENST00000408899.2	+	1	722	c.667G>A	c.(667-669)Gcc>Acc	p.A223T		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					CATCCTGGCCGCCATCTTGAG	0.607													5	296					0	0	1	0	0	A	143826872	G	A	143826872	3	1	44	1	0	0	0	0	1	0	0	0	11023	1087	38	1	669	1	OR2A14	7	143826872	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	8522531	143826872	15311791	63	4082										
HR	55806	broad.mit.edu	37	chr8	21986672	21986672	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtgcccttcaggaagctgggCgtactctccatcactctcct	9	15	4	0	rs148136587		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:21986672C>T	ENST00000381418.4	-	2	1492	c.12G>A	c.(10-12)acG>acA	p.T4T	HR_ENST00000312841.8_Silent_p.T4T	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	4							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGAAGCTGGGCGTACTCTCCA	0.632													48	62					0	0	1	0	0	T	21986672	C	T	21986672	2	4	44	1	0	0	0	0	0	0	0	1	7387	755	27	1		1	HR	8	21986672	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		21986672	124377350	64	4083										
ADAM9	8754	broad.mit.edu	37	chr8	38865443	38865443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atctttcttcttatgaaattAtaactccttggagattaact	4	7	3	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:38865443A>G	ENST00000487273.2	+	2	214	c.136A>G	c.(136-138)Ata>Gta	p.I46V	ADAM9_ENST00000481513.1_Missense_Mutation_p.I46V|ADAM9_ENST00000466936.1_Missense_Mutation_p.I46V	NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	46				Missing (in Ref. 2; no nucleotide entry).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			TTATGAAATTATAACTCCTTG	0.318													20	21					0	0	1	0	0	G	38865443	A	G	38865443	3	3	44	1	0	0	0	0	1	0	0	0	252	449	16	4	142	4	ADAM9	8	38865443	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	16878771	38865443	107498579	65	4084										
SLC20A2	6575	broad.mit.edu	37	chr8	42275340	42275340	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atcacacatatggaaggatcCcatacatgagaagagccatg	9	9	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:42275340C>A	ENST00000342228.3	-	11	2309	c.1940G>T	c.(1939-1941)gGg>gTg	p.G647V	SLC20A2_ENST00000520179.1_Missense_Mutation_p.G647V|SLC20A2_ENST00000520262.1_Missense_Mutation_p.G647V	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	647					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGGAAGGATCCCATACATGAG	0.552													14	56					1.49906e-05	1.56007e-05	1	1	0	A	42275340	C	A	42275340	3	1	44	1	0	0	0	0	1	0	0	0	14493	623	22	5	22	5	SLC20A2	8	42275340	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	3409897	42275340	104088682	66	4085										
ERMP1	79956	broad.mit.edu	37	chr9	5787228	5787228	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tccttcagagcatccagttgAggggatctcttgtcttcccc	9	13	3	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:5787228A>G	ENST00000339450.5	-	15	2720	c.2631T>C	c.(2629-2631)ccT>ccC	p.P877P	ERMP1_ENST00000543230.1_3'UTR|ERMP1_ENST00000214893.5_5'UTR|ERMP1_ENST00000381506.3_3'UTR	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	877					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		CATCCAGTTGAGGGGATCTCT	0.473													20	26					0	0	1	0	0	G	5787228	A	G	5787228	2	3	44	1	0	0	0	0	0	0	0	1	5264	291	11	4		4	ERMP1	9	5787228	Silent	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08		5787228	135426203	67	4086										
BNC2	54796	broad.mit.edu	37	chr9	16419174	16419174	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tgtacattttgtggcaaatgTtgcacatgatcccaccattg	8	9	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:16419174T>C	ENST00000380672.4	-	7	3170	c.3113A>G	c.(3112-3114)aAc>aGc	p.N1038S	BNC2_ENST00000380667.2_Missense_Mutation_p.N971S|BNC2_ENST00000545497.1_Missense_Mutation_p.N943S	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	1038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GTGGCAAATGTTGCACATGAT	0.512													22	29					0	0	1	0	0	C	16419174	T	C	16419174	3	2	44	1	0	0	0	0	1	0	0	0	1474	1725	60	4	190	4	BNC2	9	16419174	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	10631946	16419174	124794257	68	4087										
SLC24A2	25769	broad.mit.edu	37	chr9	19786016	19786016	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	acccatttttctacttggacGttgaatttcatgaaaaccac	5	10	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:19786016G>A	ENST00000341998.2	-	1	910	c.849C>T	c.(847-849)aaC>aaT	p.N283N	SLC24A2_ENST00000286344.3_Silent_p.N283N	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	283					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		CTACTTGGACGTTGAATTTCA	0.408													37	54					0	0	1	0	0	A	19786016	G	A	19786016	2	1	44	1	0	0	0	0	0	0	0	1	14520	1136	40	1		1	SLC24A2	9	19786016	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	3366842	19786016	121427415	69	4088										
RASEF	158158	broad.mit.edu	37	chr9	85615415	85615415	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tgccttcactaacagaccctTggggcttccagtctaagacg	9	13	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:85615415T>C	ENST00000376447.3	-	11	1768	c.1508A>G	c.(1507-1509)cAa>cGa	p.Q503R		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	503					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						AACAGACCCTTGGGGCTTCCA	0.443													4	22					0	0	1	0	0	C	85615415	T	C	85615415	3	2	44	1	0	0	0	0	1	0	0	0	13119	1812	63	4	742	4	RASEF	9	85615415	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	65829399	85615415	55598016	70	4089										
FANCC	2176	broad.mit.edu	37	chr9	97912337	97912337	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	taataagtgggacacaaactCgtgacagggacgccactcgc	11	11	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:97912337C>T	ENST00000289081.3	-	7	808	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	FANCC_ENST00000375305.1_Missense_Mutation_p.R185Q	NM_000136.2	NP_000127.2	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	185					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)|skin(1)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(62;0.138)				GACACAAACTCGTGACAGGGA	0.473			"D, Mis, N, F, S"			"AML, leukemia"		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	8					0	0	1	0	0	T	97912337	C	T	97912337	3	4	44	1	0	0	0	0	1	0	0	0	5696	884	31	1	1158	1	FANCC	9	97912337	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	12296922	97912337	43301094	71	4090										
UAP1L1	91373	broad.mit.edu	37	chr9	139972957	139972957	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ccgcgcctcccttgcaggtaCgtcatgaccagcgagttcac	10	16	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:139972957C>T	ENST00000409858.3	+	3	530	c.498C>T	c.(496-498)taC>taT	p.Y166Y	UAP1L1_ENST00000476184.1_3'UTR|UAP1L1_ENST00000360271.3_Silent_p.Y43Y	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	166							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CTTGCAGGTACGTCATGACCA	0.667													13	18					0	0	1	0	0	T	139972957	C	T	139972957	2	4	44	1	0	0	0	0	0	0	0	1	16886	547	19	1		1	UAP1L1	9	139972957	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	42060620	139972957	1240474	72	4091										
ZEB1	6935	broad.mit.edu	37	chr10	31815734	31815734	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gaaagcgcttctcacactctGggtcttattctcaacacatg	7	12	4	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:31815734G>A	ENST00000446923.2	+	9	3260	c.2869G>A	c.(2869-2871)Ggg>Agg	p.G957R	ZEB1_ENST00000320985.10_Missense_Mutation_p.G973R|ZEB1_ENST00000560721.2_Missense_Mutation_p.G953R|ZEB1_ENST00000361642.5_Missense_Mutation_p.G974R|ZEB1_ENST00000542815.3_Missense_Mutation_p.G906R	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	973					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.G973W(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CTCACACTCTGGGTCTTATTC	0.443													32	0					0	0	1	0	0	A	31815734	G	A	31815734	3	1	44	1	0	0	0	0	1	0	0	0	17680	1348	47	3	2965	3	ZEB1	10	31815734	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		31815734	103719013	73	4092										
ARHGAP12	94134	broad.mit.edu	37	chr10	32197365	32197366	+	Frame_Shift_Ins	INS	-	-	A													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gacagtctgaccttgattatINSaactgggtccaaaattctga							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:32197365_32197366insA	ENST00000375250.5	-	3	659_660	c.418_419insT	c.(418-420)taafs	p.*140fs	ARHGAP12_ENST00000311380.4_Frame_Shift_Ins_p.*140fs|ARHGAP12_ENST00000396144.4_Frame_Shift_Ins_p.*140fs|ARHGAP12_ENST00000344936.2_Frame_Shift_Ins_p.*140fs|ARHGAP12_ENST00000375245.4_Frame_Shift_Ins_p.*140fs	NM_001270696.1	NP_001257625.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	140					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				ACCTTGATTATAACTGGGTCCA	0.421													57	4	---	---	---	---						A	32197366	-	A	32197365	7	5	44	1	0	1	1	0	0	0	0	0	862	1406	49	0	2193	0	ARHGAP12	10	32197365	Frame_Shift_Ins	INS	-	TCGA-NA-A4R1-01A-11D-A28R-08	381631	32197365	103337382	74	4093										
TFAM	7019	broad.mit.edu	37	chr10	60154714	60154714	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	attcagcatgctaaagaggaCgaaactcgttatcataatga	8	7	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:60154714C>T	ENST00000487519.1	+	7	1147	c.621C>T	c.(619-621)gaC>gaT	p.D207D	TFAM_ENST00000373899.3_3'UTR|TFAM_ENST00000373895.3_Silent_p.D175D	NM_003201.1	NP_003192.1	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial	207					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						CTAAAGAGGACGAAACTCGTT	0.289													3	1					0	0	1	0	0	T	60154714	C	T	60154714	2	4	44	1	0	0	0	0	0	0	0	1	15845	535	19	1		1	TFAM	10	60154714	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	27957349	60154714	75380033	75	4094										
ANK3	288	broad.mit.edu	37	chr10	61829384	61829384	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tttcattttctaatccctgaCaactggtcatcaccgcttct	4	13	5	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:61829384C>A	ENST00000280772.1	-	37	11446	c.11255G>T	c.(11254-11256)tGt>tTt	p.C3752F	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3752					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TAATCCCTGACAACTGGTCAT	0.398													54	6					1.46156e-29	1.61493e-29	1	1	0	A	61829384	C	A	61829384	3	1	44	1	0	0	0	0	1	0	0	0	618	478	17	5	2219	5	ANK3	10	61829384	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	1674670	61829384	73705363	76	4095										
PTEN	5728	broad.mit.edu	37	chr10	89717672	89717672	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctccaattcaggacccacaCgacgggaagacaagttcatg	9	13	2	1	rs121909219		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:89717672C>T	ENST00000371953.3	+	7	2054	c.697C>T	c.(697-699)Cga>Tga	p.R233*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(77)|p.0?(37)|p.R55fs*1(5)|p.R233fs*10(3)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423	R233*(HEC59_ENDOMETRIUM)|R233*(JHUEM1_ENDOMETRIUM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)	31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			40	1					0	0	1	0	0	T	89717672	C	T	89717672	4	4	44	1	0	0	0	0	0	1	0	0	12786	528	19	1	723	1	PTEN	10	89717672	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	27888288	89717672	45817075	77	4096										
KNDC1	85442	broad.mit.edu	37	chr10	135000063	135000063	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gacttcacaccccagccaggGgccagcagaggcccctgcag	12	17	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:135000063G>A	ENST00000304613.3	+	6	1232	c.1211G>A	c.(1210-1212)gGg>gAg	p.G404E	KNDC1_ENST00000368572.2_Missense_Mutation_p.G404E|KNDC1_ENST00000368571.2_Missense_Mutation_p.G339E			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	404					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCCAGCCAGGGGCCAGCAGAG	0.662													38	2					0	0	1	0	0	A	135000063	G	A	135000063	3	1	44	1	0	0	0	0	1	0	0	0	8468	1232	43	3	1233	3	KNDC1	10	135000063	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	45282391	135000063	534684	78	4097										
CDHR5	53841	broad.mit.edu	37	chr11	619490	619490	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcacctctgcgtagaaggctCccgcctgtgccagtgtggtg	14	13	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:619490C>A	ENST00000358353.3	-	12	1599	c.1277G>T	c.(1276-1278)gGa>gTa	p.G426V	CDHR5_ENST00000397542.2_Missense_Mutation_p.G426V|CDHR5_ENST00000349570.7_Missense_Mutation_p.G426V			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	426	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GTAGAAGGCTCCCGCCTGTGC	0.607													45	2					6.18754e-15	6.67211e-15	1	1	0	A	619490	C	A	619490	3	1	44	1	0	0	0	0	1	0	0	0	3144	855	30	2	1280	2	CDHR5	11	619490	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		619490	134387026	79	4098										
MUC2	4583	broad.mit.edu	37	chr11	1083268	1083268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	caagtgctcctgttaccaccGcggtctctacctggaggcgg	12	14	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:1083268G>A	ENST00000441003.2	+	16	2195	c.2168G>A	c.(2167-2169)cGc>cAc	p.R723H	MUC2_ENST00000359061.5_Missense_Mutation_p.R723H	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	723						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGTTACCACCGCGGTCTCTAC	0.682													6	11					0	0	1	0	0	A	1083268	G	A	1083268	3	1	44	1	0	0	0	0	1	0	0	0	10022	1087	38	1	2230	1	MUC2	11	1083268	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	463778	1083268	133923248	80	4099										
COPB1	1315	broad.mit.edu	37	chr11	14481798	14481798	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	attggttgactttaatatgtGctgtaagtagtcatttaaat	8	3	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:14481798G>A	ENST00000249923.3	-	20	2902	c.2602C>T	c.(2602-2604)Cac>Tac	p.H868Y	COPB1_ENST00000439561.2_Missense_Mutation_p.H868Y	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	868					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TTTAATATGTGCTGTAAGTAG	0.358													14	0					0	0	1	0	0	A	14481798	G	A	14481798	3	1	44	1	0	0	0	0	1	0	0	0	3751	1319	46	3	271	3	COPB1	11	14481798	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	13398530	14481798	120524718	81	4100										
ATL3	25923	broad.mit.edu	37	chr11	63438805	63438805	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gccactcgctgaggggacaaCatggagcctccgccttcaaa	11	14	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:63438805C>T	ENST00000332645.4	-	2	158	c.159G>A	c.(157-159)atG>atA	p.M53I	ATL3_ENST00000535789.1_5'UTR|ATL3_ENST00000538786.1_Intron|ATL3_ENST00000398868.3_Start_Codon_SNP_p.M1I			Q6DD88	ATLA3_HUMAN	atlastin GTPase 3	1					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						GAGGGGACAACATGGAGCCTC	0.687													3	17					0	0	1	0	0	T	63438805	C	T	63438805	3	4	44	1	0	0	0	0	1	0	0	0	1107	478	17	3	1674	3	ATL3	11	63438805	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	48957007	63438805	71567711	82	4101										
AIP	9049	broad.mit.edu	37	chr11	67254583	67254583	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	catcattggcaagaagttcaAgctgcctgtgtgggagacca	12	9	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:67254583A>G	ENST00000279146.3	+	2	324	c.206A>G	c.(205-207)aAg>aGg	p.K69R		NM_003977.2	NP_003968.2	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	69	PPIase FKBP-type.				protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(2)	7						AAGAAGTTCAAGCTGCCTGTG	0.592									Familial Isolated Pituitary Adenoma				70	102					0	0	1	0	0	G	67254583	A	G	67254583	3	3	44	1	0	0	0	0	1	0	0	0	432	72	3	4	212	4	AIP	11	67254583	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	3815778	67254583	67751933	83	4102										
MYO7A	4647	broad.mit.edu	37	chr11	76877132	76877132	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gaagaaccgagacaccctgcAtggggacattatccagctgg	12	11	0	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:76877132A>G	ENST00000409709.3	+	15	1993	c.1721A>G	c.(1720-1722)cAt>cGt	p.H574R	MYO7A_ENST00000458637.2_Missense_Mutation_p.H574R|MYO7A_ENST00000409893.1_Missense_Mutation_p.H574R|MYO7A_ENST00000409619.2_Missense_Mutation_p.H563R	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	574	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GACACCCTGCATGGGGACATT	0.562													10	33					0	0	1	0	0	G	76877132	A	G	76877132	3	3	44	1	0	0	0	0	1	0	0	0	10129	217	8	4	1775	4	MYO7A	11	76877132	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	9622549	76877132	58129384	84	4103										
DNAJC14	85406	broad.mit.edu	37	chr12	56221932	56221932	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gagagattcttcatcatcatAttcctcttccaactcatctt	3	12	7	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:56221932A>G	ENST00000357606.3	-	3	800	c.511T>C	c.(511-513)Tat>Cat	p.Y171H	DNAJC14_ENST00000317287.5_Missense_Mutation_p.Y171H|DNAJC14_ENST00000317269.3_Missense_Mutation_p.Y171H			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	171					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						TCATCATCATATTCCTCTTCC	0.502													40	42					0	0	1	0	0	G	56221932	A	G	56221932	3	3	44	1	0	0	0	0	1	0	0	0	4660	449	16	4	1621	4	DNAJC14	12	56221932	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08		56221932	77629963	85	4104										
USP15	9958	broad.mit.edu	37	chr12	62786091	62786091	+	Frame_Shift_Del	DEL	A	A	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtgtggagtataaacctcctAaaaaaccctttgtgaaatta							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:62786091delA	ENST00000280377.5	+	18	2402	c.2344delA	c.(2344-2346)aafs	p.K783fs	USP15_ENST00000393654.3_Frame_Shift_Del_p.K758fs|USP15_ENST00000353364.3_Frame_Shift_Del_p.K754fs	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	783					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TAAACCTCCTAAAAAACCCTT	0.303													13	0	---	---	---	---						-	62786091	A	-	62786091	7	5	44	1	0	1	0	1	0	0	0	0	17105	363	13	0	2323	0	USP15	12	62786091	Frame_Shift_Del	DEL	A	TCGA-NA-A4R1-01A-11D-A28R-08	6564159	62786091	71065804	86	4105										
APAF1	317	broad.mit.edu	37	chr12	99053108	99053108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtctccgcattctgatgcttCgcaaacacccaaggtaccga	8	14	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:99053108C>T	ENST00000357310.1	+	5	1274	c.697C>T	c.(697-699)Cgc>Tgc	p.R233C	APAF1_ENST00000359972.2_Missense_Mutation_p.R222C|APAF1_ENST00000333991.1_Missense_Mutation_p.R233C|APAF1_ENST00000549007.1_Missense_Mutation_p.R233C|APAF1_ENST00000339433.3_Missense_Mutation_p.R233C|APAF1_ENST00000550527.1_Missense_Mutation_p.R222C|APAF1_ENST00000547045.1_Missense_Mutation_p.R233C|APAF1_ENST00000552268.1_Missense_Mutation_p.R233C|APAF1_ENST00000551964.1_Missense_Mutation_p.R233C	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	233	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TCTGATGCTTCGCAAACACCC	0.453													12	10					0	0	1	0	0	T	99053108	C	T	99053108	3	4	44	1	0	0	0	0	1	0	0	0	751	884	31	1	711	1	APAF1	12	99053108	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	36267017	99053108	34798787	87	4106										
TCTN1	79600	broad.mit.edu	37	chr12	111064170	111064170	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atttttttaattttcaggggCgacagccagttttgtagtca	9	6	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:111064170C>T	ENST00000551590.1	+	3	501	c.345C>T	c.(343-345)ggC>ggT	p.G115G	TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000471804.2_Silent_p.G115G|TCTN1_ENST00000397659.4_Silent_p.G115G|TCTN1_ENST00000377654.3_5'UTR|TCTN1_ENST00000550703.2_Silent_p.G115G|TCTN1_ENST00000397655.3_Silent_p.G115G			Q2MV58	TECT1_HUMAN	tectonic family member 1	115					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						ttttCAGGGGCGACAGCCAGT	0.318													5	1					0	0	1	0	0	T	111064170	C	T	111064170	2	4	44	1	0	0	0	0	0	0	0	1	15780	755	27	1		1	TCTN1	12	111064170	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	12011062	111064170	22787725	88	4107										
RHOF	54509	broad.mit.edu	37	chr12	122231493	122231494	+	Frame_Shift_Del	DEL	CC	CC	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cgatcttcagctccttcctgCccggaccgggggcggcggtc							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:122231493_122231494delCC	ENST00000267205.2	-	1	674_675	c.46_47delGG	c.(46-48)cfs	p.G16fs	RP11-347I19.3_ENST00000545544.1_RNA	NM_019034.2	NP_061907.2	Q9HBH0	RHOF_HUMAN	ras homolog family member F (in filopodia)	16					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			large_intestine(1)|lung(1)|ovary(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CTCCTTCCTGCCCGGACCGGGG	0.733													2	4	---	---	---	---						-	122231494	CC	-	122231493	7	5	44	1	0	1	0	1	0	0	0	0	13387	739	26	0	608	0	RHOF	12	122231493	Frame_Shift_Del	DEL	CC	TCGA-NA-A4R1-01A-11D-A28R-08	11167323	122231493	11620402	89	4108										
LRRC43	254050	broad.mit.edu	37	chr12	122672355	122672355	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cacaacaaacttctaggcccCttggaaagtctctacgtcac	6	14	3	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:122672355C>A	ENST00000339777.4	+	4	658	c.630C>A	c.(628-630)ccC>ccA	p.P210P	LRRC43_ENST00000425921.1_Silent_p.P25P	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	210										NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		TTCTAGGCCCCTTGGAAAGTC	0.562													25	12					1.55811e-20	1.69031e-20	1	1	0	A	122672355	C	A	122672355	2	1	44	1	0	0	0	0	0	0	0	1	9045	668	24	5		5	LRRC43	12	122672355	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	440862	122672355	11179540	90	4109										
POLE	5426	broad.mit.edu	37	chr12	133225985	133225985	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ggaccatcccggatggccccGggcctgagcacaccctctgc	12	18	1	1	rs116482376	by1000genomes	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:133225985G>A	ENST00000320574.5	-	31	3955	c.3912C>T	c.(3910-3912)ccC>ccT	p.P1304P	POLE_ENST00000535270.1_Silent_p.P1277P	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1304					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGATGGCCCCGGGCCTGAGCA	0.662								DNA polymerases (catalytic subunits)					34	38					0	0	1	0	0	A	133225985	G	A	133225985	2	1	44	1	0	0	0	0	0	0	0	1	12243	1103	39	1		1	POLE	12	133225985	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	10553630	133225985	625910	91	4110										
LATS2	26524	broad.mit.edu	37	chr13	21562146	21562147	+	Frame_Shift_Del	DEL	CT	CT	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gagtagctcttgatgcgtgaCtctctcttctcttcgtctct							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:21562146_21562147delCT	ENST00000382592.4	-	4	2177_2178	c.1772_1773delAG	c.(1771-1773)gfs	p.E591fs	LATS2_ENST00000542899.1_Frame_Shift_Del_p.E591fs	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	591					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TGATGCGTGACTCTCTCTTCTC	0.515													89	105	---	---	---	---						-	21562147	CT	-	21562146	7	5	44	1	0	1	0	1	0	0	0	0	8685	564	20	0	1513	0	LATS2	13	21562146	Frame_Shift_Del	DEL	CT	TCGA-NA-A4R1-01A-11D-A28R-08		21562146	93607732	92	4111										
PABPC3	5042	broad.mit.edu	37	chr13	25670421	25670421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tgactgaggcgatgctctacGagaagttcagcccggcaggg	15	10	2	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:25670421G>A	ENST00000281589.3	+	1	122	c.85G>A	c.(85-87)Gag>Aag	p.E29K		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	29	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GATGCTCTACGAGAAGTTCAG	0.627													55	55					0	0	1	0	0	A	25670421	G	A	25670421	3	1	44	1	0	0	0	0	1	0	0	0	11411	1059	37	1	87	1	PABPC3	13	25670421	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	4108275	25670421	89499457	93	4112										
RB1	5925	broad.mit.edu	37	chr13	48953760	48953760	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttggagttcgcttgtattacCgagtaatggaatccatgctt	10	7	0	0	rs121913302		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:48953760C>T	ENST00000267163.4	+	14	1501	c.1363C>T	c.(1363-1365)Cga>Tga	p.R455*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	455	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)|p.R455*(7)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTGTATTACCGAGTAATGGA	0.358		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			2	0					0	0	1	0	0	T	48953760	C	T	48953760	4	4	44	1	0	0	0	0	0	1	0	0	13149	644	23	1	1417	1	RB1	13	48953760	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	23283339	48953760	66216118	94	4113										
DIS3	22894	broad.mit.edu	37	chr13	73346315	73346315	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	acctccaaatttccattttcGagttctcgacaatgtagagc	6	11	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:73346315G>A	ENST00000377767.4	-	10	1585	c.1485C>T	c.(1483-1485)ctC>ctT	p.L495L	DIS3_ENST00000545453.1_Silent_p.L333L|DIS3_ENST00000377780.4_Silent_p.L465L	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	495					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TTCCATTTTCGAGTTCTCGAC	0.363										Multiple Myeloma(4;0.011)			19	20					0	0	1	0	0	A	73346315	G	A	73346315	2	1	44	1	0	0	0	0	0	0	0	1	4563	1045	37	1		1	DIS3	13	73346315	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	24392555	73346315	41823563	95	4114										
ACIN1	22985	broad.mit.edu	37	chr14	23530753	23530753	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cgggggtgggggtggggggtGcaggggccgtggtattccct	24	7	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:23530753G>A	ENST00000262710.1	-	17	3679	c.3352C>T	c.(3352-3354)Cac>Tac	p.H1118Y	ACIN1_ENST00000397341.3_Missense_Mutation_p.H360Y|ACIN1_ENST00000605057.1_Missense_Mutation_p.H1060Y|ACIN1_ENST00000457657.1_Missense_Mutation_p.H1078Y|ACIN1_ENST00000557515.1_Missense_Mutation_p.H359Y|ACIN1_ENST00000338631.6_Missense_Mutation_p.H391Y|ACIN1_ENST00000357481.2_Missense_Mutation_p.H360Y|ACIN1_ENST00000555053.1_Missense_Mutation_p.H1105Y	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1118	Pro-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGTGGGGGGTGCAGGGGCCGT	0.662													6	6					0	0	1	0	0	A	23530753	G	A	23530753	3	1	44	1	0	0	0	0	1	0	0	0	142	1319	46	3	685	3	ACIN1	14	23530753	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		23530753	83818787	96	4115										
MYH7	4625	broad.mit.edu	37	chr14	23891485	23891485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctccagcttccgcttcgctCgctccaggtccatgcgcacc	8	20	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:23891485C>T	ENST00000355349.3	-	25	3311	c.3149G>A	c.(3148-3150)cGa>cAa	p.R1050Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1050					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCGCTTCGCTCGCTCCAGGTC	0.577													25	23					0	0	1	0	0	T	23891485	C	T	23891485	3	4	44	1	0	0	0	0	1	0	0	0	10086	884	31	1	2722	1	MYH7	14	23891485	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	360732	23891485	83458055	97	4116										
NYNRIN	57523	broad.mit.edu	37	chr14	24885925	24885925	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctgaagccctacacacacaCggctgtggcccaggtgctgc	11	16	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:24885925C>T	ENST00000382554.3	+	9	5288	c.4970C>T	c.(4969-4971)aCg>aTg	p.T1657M		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1657	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TACACACACACGGCTGTGGCC	0.602													22	22					0	0	1	0	0	T	24885925	C	T	24885925	3	4	44	1	0	0	0	0	1	0	0	0	10843	536	19	1	5000	1	NYNRIN	14	24885925	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	994440	24885925	82463615	98	4117										
FAM179B	23116	broad.mit.edu	37	chr14	45481246	45481246	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttcttctgcaaagaaaaaaaTttctcatattgctgaacaaa	4	7	3	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:45481246T>A	ENST00000361462.2	+	7	3389	c.3206T>A	c.(3205-3207)aTt>aAt	p.I1069N	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Missense_Mutation_p.I1069N|FAM179B_ENST00000382233.2_Missense_Mutation_p.N991K			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1069	Ser-rich.						binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						AAGAAAAAAATTTCTCATATT	0.294													4	44					0	0	1	0	0	A	45481246	T	A	45481246	3	1	44	1	0	0	0	0	1	0	0	0	5535	1493	52	4	3232	4	FAM179B	14	45481246	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	20595321	45481246	61868294	99	4118										
WDHD1	11169	broad.mit.edu	37	chr14	55429738	55429738	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	acctgggttgctgtcaattcGgctgccttctctacagccag	10	13	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:55429738G>A	ENST00000360586.3	-	19	2528	c.2463C>T	c.(2461-2463)gcC>gcT	p.A821A	WDHD1_ENST00000420358.2_Silent_p.A698A|WDHD1_ENST00000421192.1_Silent_p.A698A|WDHD1_ENST00000359167.4_Silent_p.A339A	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	821						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						CTGTCAATTCGGCTGCCTTCT	0.383													12	13					0	0	1	0	0	A	55429738	G	A	55429738	2	1	44	1	0	0	0	0	0	0	0	1	17330	1103	39	1		1	WDHD1	14	55429738	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	9948492	55429738	51919802	100	4119										
SPTB	6710	broad.mit.edu	37	chr14	65270419	65270419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ccatgttctccaggtgtacaCgctgctccttgaggaactgg	11	12	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:65270419C>T	ENST00000389722.3	-	3	433	c.380G>A	c.(379-381)cGt>cAt	p.R127H	SPTB_ENST00000556626.1_Missense_Mutation_p.R127H|SPTB_ENST00000542895.1_Missense_Mutation_p.R127H|SPTB_ENST00000389720.3_Missense_Mutation_p.R127H|SPTB_ENST00000389721.5_Missense_Mutation_p.R127H	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	127	Actin-binding.|CH 1.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CAGGTGTACACGCTGCTCCTT	0.607													13	43					0	0	1	0	0	T	65270419	C	T	65270419	3	4	44	1	0	0	0	0	1	0	0	0	15173	536	19	1	6807	1	SPTB	14	65270419	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	9840681	65270419	42079121	101	4120										
DLST	1743	broad.mit.edu	37	chr14	75359578	75359578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cggctgaagctcctgctgctGcagccccaaaagcagaacct	10	15	0	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:75359578G>A	ENST00000334220.4	+	8	545	c.484G>A	c.(484-486)Gca>Aca	p.A162T	DLST_ENST00000555190.1_3'UTR|DLST_ENST00000334212.6_Missense_Mutation_p.A76T	NM_001933.4	NP_001924.2	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	162					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(234;0.00698)		TCCTGCTGCTGCAGCCCCAAA	0.572													26	39					0	0	1	0	0	A	75359578	G	A	75359578	3	1	44	1	0	0	0	0	1	0	0	0	4597	1319	46	3	514	3	DLST	14	75359578	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	10089159	75359578	31989962	102	4121										
KLC1	3831	broad.mit.edu	37	chr14	104124027	104124027	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agaaactgcagaagagtgagCagtctgtggctcaactggag	14	7	2	4			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:104124027C>T	ENST00000389744.4	+	3	675	c.406C>T	c.(406-408)Cag>Tag	p.Q136*	KLC1_ENST00000555836.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000347839.6_Nonsense_Mutation_p.Q136*|RP11-73M18.2_ENST00000472726.2_Nonsense_Mutation_p.Q308*|KLC1_ENST00000452929.2_Nonsense_Mutation_p.Q136*|KLC1_ENST00000348520.6_Nonsense_Mutation_p.Q136*|KLC1_ENST00000553286.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000554280.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000557575.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000334553.6_Nonsense_Mutation_p.Q136*|KLC1_ENST00000445352.4_Nonsense_Mutation_p.Q136*|KLC1_ENST00000380038.3_Nonsense_Mutation_p.Q136*|KLC1_ENST00000246489.7_Nonsense_Mutation_p.Q136*|KLC1_ENST00000557450.1_Nonsense_Mutation_p.Q136*			Q07866	KLC1_HUMAN	kinesin light chain 1	136					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				GAAGAGTGAGCAGTCTGTGGC	0.507													27	74					0	0	1	0	0	T	104124027	C	T	104124027	4	4	44	1	0	0	0	0	0	1	0	0	8375	711	25	3	412	3	KLC1	14	104124027	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	28764449	104124027	3225513	103	4122										
FMN1	342184	broad.mit.edu	37	chr15	33261469	33261469	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctttcacagggcttgaggaaGgtctctctgtctgtctggac	12	10	5	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:33261469G>T	ENST00000334528.9	-	4	1763	c.1764C>A	c.(1762-1764)acC>acA	p.T588T	FMN1_ENST00000559047.1_Silent_p.T811T|FMN1_ENST00000561249.1_Silent_p.T713T	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	811	Mediates interaction with alpha-catenin (By similarity).|Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GCTTGAGGAAGGTCTCTCTGT	0.473													5	190					0.000602214	0.000615979	1	1	0	T	33261469	G	T	33261469	2	4	44	1	0	0	0	0	0	0	0	1	5981	987	35	5		5	FMN1	15	33261469	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		33261469	69269923	104	4123										
LTK	4058	broad.mit.edu	37	chr15	41796335	41796336	+	Frame_Shift_Ins	INS	-	-	G													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gactcagttcctggggctgtINSgggggtcttaggcactccaa							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:41796335_41796336insG	ENST00000263800.6	-	20	2549_2550	c.2453_2454insC	c.(2452-2454)ccafs	p.P818fs	LTK_ENST00000355166.5_Frame_Shift_Ins_p.P757fs|LTK_ENST00000561619.1_Frame_Shift_Ins_p.P516fs|LTK_ENST00000453182.2_Frame_Shift_Ins_p.P688fs	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	818					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCTGGGGCTGTGGGGGTCTTAG	0.604										TSP Lung(18;0.14)			20	20	---	---	---	---						G	41796336	-	G	41796335	7	5	44	1	0	1	1	0	0	0	0	0	9124	1683	59	0	144	0	LTK	15	41796335	Frame_Shift_Ins	INS	-	TCGA-NA-A4R1-01A-11D-A28R-08	8534866	41796335	60735057	105	4124										
TGM5	9333	broad.mit.edu	37	chr15	43544969	43544969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cctcctacctgtgcacatgaCggcagcaaagacccagcatt	8	15	0	2	rs144575810	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:43544969C>T	ENST00000220420.5	-	6	857	c.850G>A	c.(850-852)Gtc>Atc	p.V284I	TGM5_ENST00000349114.4_Missense_Mutation_p.V202I	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	284					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GTGCACATGACGGCAGCAAAG	0.587													102	2					0	0	1	0	0	T	43544969	C	T	43544969	3	4	44	1	0	0	0	0	1	0	0	0	15892	536	19	1	1344	1	TGM5	15	43544969	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	1748634	43544969	58986423	106	4125										
TGM7	116179	broad.mit.edu	37	chr15	43574783	43574783	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atcctggtgggagatctttcCggatcatccagcactcattc	9	12	3	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:43574783C>T	ENST00000452443.2	-	8	1044	c.1040G>A	c.(1039-1041)cGg>cAg	p.R347Q		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	347					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GAGATCTTTCCGGATCATCCA	0.552													3	2					0	0	1	0	0	T	43574783	C	T	43574783	3	4	44	1	0	0	0	0	1	0	0	0	15894	652	23	1	1116	1	TGM7	15	43574783	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	29814	43574783	58956609	107	4126										
AKAP13	11214	broad.mit.edu	37	chr15	86122535	86122535	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gattgtggagtaaagggcacGgaaggcctttcgtcctgtgg	16	7	0	0	rs140888795		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:86122535G>A	ENST00000394518.2	+	7	1331	c.1236G>A	c.(1234-1236)acG>acA	p.T412T	RP11-815J21.2_ENST00000561409.1_RNA|AKAP13_ENST00000361243.2_Silent_p.T412T	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	412					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TAAAGGGCACGGAAGGCCTTT	0.512													42	44					0	0	1	0	0	A	86122535	G	A	86122535	2	1	44	1	0	0	0	0	0	0	0	1	446	1103	39	1		1	AKAP13	15	86122535	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	42547752	86122535	16408857	108	4127										
AKAP13	11214	broad.mit.edu	37	chr15	86259071	86259071	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtcctcctggtggatgaaacCgctaccaccccaatatttgc	8	14	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:86259071C>T	ENST00000394518.2	+	20	5747	c.5652C>T	c.(5650-5652)acC>acT	p.T1884T	AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Silent_p.T1888T|AKAP13_ENST00000394510.2_Silent_p.T129T	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1884					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TGGATGAAACCGCTACCACCC	0.517													14	47					0	0	1	0	0	T	86259071	C	T	86259071	2	4	44	1	0	0	0	0	0	0	0	1	446	639	23	1		1	AKAP13	15	86259071	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	136536	86259071	16272321	109	4128										
HAGHL	84264	broad.mit.edu	37	chr16	778930	778930	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ccgccgcggcaagagggtggGgggggagggaacaggcttcg	22	9	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:778930G>T	ENST00000341413.4	+	7	916	c.635G>T	c.(634-636)gGg>gTg	p.G212V	HAGHL_ENST00000564537.1_3'UTR|HAGHL_ENST00000549114.1_3'UTR|HAGHL_ENST00000564545.1_3'UTR|HAGHL_ENST00000561546.1_Intron|HAGHL_ENST00000389703.3_Intron			Q6PII5	HAGHL_HUMAN	hydroxyacylglutathione hydrolase-like	212							hydrolase activity|metal ion binding			lung(3)	3		Hepatocellular(780;0.00335)				AAGAGGGTGGGGGGGGAGGGA	0.652													4	2					0.000602214	0.000615979	1	1	0	T	778930	G	T	778930	3	4	44	1	0	0	0	0	1	0	0	0	6986	1232	43	5	657	5	HAGHL	16	778930	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		778930	89575823	110	4129										
CACNA1H	8912	broad.mit.edu	37	chr16	1270130	1270130	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cgctccccacggcccgccagCgtccgcactcgtaagcatac	9	20	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:1270130C>T	ENST00000348261.5	+	35	6446	c.6198C>T	c.(6196-6198)agC>agT	p.S2066S	CACNA1H_ENST00000358590.4_Silent_p.S2060S|CACNA1H_ENST00000565831.1_Silent_p.S2060S	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2066					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGCCCGCCAGCGTCCGCACTC	0.721													16	4					0	0	1	0	0	T	1270130	C	T	1270130	2	4	44	1	0	0	0	0	0	0	0	1	2563	767	27	1		1	CACNA1H	16	1270130	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	491200	1270130	89084623	111	4130										
PTX4	390667	broad.mit.edu	37	chr16	1536186	1536186	+	Frame_Shift_Del	DEL	G	G	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	cccagcacgagggaccctccGggggggatctcatagccctc					rs148668779		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:1536186delG	ENST00000447419.2	-	3	1216	c.1191delC	c.(1189-1191)ccfs	p.P397fs	PTX4_ENST00000440447.2_3'UTR|PTX4_ENST00000293922.1_Frame_Shift_Del_p.P392fs			Q96A99	PTX4_HUMAN	pentraxin 4, long	397	Pentaxin.					extracellular region	metal ion binding	p.G393fs*57(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GGGACCCTCCGGGGGGGATCT	0.667													30	47	---	---	---	---						-	1536186	G	-	1536186	7	5	44	1	0	1	0	1	0	0	0	0	12874	1103	39	0	248	0	PTX4	16	1536186	Frame_Shift_Del	DEL	G	TCGA-NA-A4R1-01A-11D-A28R-08	266056	1536186	88818567	112	4131										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1817236	1817236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcatggctgttgtgtacgacCgcgtgtggtgtggctacaag	16	8	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:1817236C>T	ENST00000250894.4	+	26	3329	c.3172C>T	c.(3172-3174)Cgc>Tgc	p.R1058C	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.R1052C	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	1058					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						TGTGTACGACCGCGTGTGGTG	0.627													46	122					0	0	1	0	0	T	1817236	C	T	1817236	3	4	44	1	0	0	0	0	1	0	0	0	9335	652	23	1	3290	1	MAPK8IP3	16	1817236	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	281050	1817236	88537517	113	4132										
CREBBP	1387	broad.mit.edu	37	chr16	3900479	3900479	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gagatccattcatgacttgcGcctgcccttgtgaagcctga	10	12	1	4			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:3900479G>A	ENST00000262367.5	-	2	1426	c.617C>T	c.(616-618)gCg>gTg	p.A206V	CREBBP_ENST00000382070.3_Missense_Mutation_p.A206V	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	206					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CATGACTTGCGCCTGCCCTTG	0.552			"T, N, F, Mis, O"	"MLL, MORF, RUNXBP2"	"ALL, AML, DLBCL, B-NHL "		Rubinstein-Taybi syndrome						27	48					0	0	1	0	0	A	3900479	G	A	3900479	3	1	44	1	0	0	0	0	1	0	0	0	3884	1087	38	1	6831	1	CREBBP	16	3900479	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	2083243	3900479	86454274	114	4133										
XYLT1	64131	broad.mit.edu	37	chr16	17292083	17292083	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ccttacctgatggggtagtcGgccgcactcaggttgatgaa	13	10	1	3	rs149300797		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:17292083G>A	ENST00000261381.6	-	5	1359	c.1275C>T	c.(1273-1275)gcC>gcT	p.A425A		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	425					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGGGGTAGTCGGCCGCACTCA	0.622													11	66					0	0	1	0	0	A	17292083	G	A	17292083	2	1	44	1	0	0	0	0	0	0	0	1	17522	1103	39	1		1	XYLT1	16	17292083	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	13391604	17292083	73062670	115	4134										
USP31	57478	broad.mit.edu	37	chr16	23080502	23080502	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gaccagagagcgggggcaggCggtccccttgtgctgaatgt	17	10	0	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:23080502C>T	ENST00000219689.7	-	16	2923	c.2924G>A	c.(2923-2925)cGc>cAc	p.R975H	USP31_ENST00000567975.1_Missense_Mutation_p.R268H	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	975	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.R975H(1)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		CGGGGGCAGGCGGTCCCCTTG	0.517													40	52					0	0	1	0	0	T	23080502	C	T	23080502	3	4	44	1	0	0	0	0	1	0	0	0	17121	768	27	1	1138	1	USP31	16	23080502	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	5788419	23080502	67274251	116	4135										
PRPF8	10594	broad.mit.edu	37	chr17	1582969	1582969	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agcgtaggttgaagggccgcGgggcccagagcagggcaatg	19	9	0	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:1582969G>A	ENST00000572621.1	-	8	1488	c.1223C>T	c.(1222-1224)cCg>cTg	p.P408L	PRPF8_ENST00000304992.6_Missense_Mutation_p.P408L			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	408						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GAAGGGCCGCGGGGCCCAGAG	0.572													97	5					0	0	1	0	0	A	1582969	G	A	1582969	3	1	44	1	0	0	0	0	1	0	0	0	12626	1116	39	1	5924	1	PRPF8	17	1582969	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		1582969	79612241	117	4136										
CXCL16	58191	broad.mit.edu	37	chr17	4638656	4638656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atcctactgggagggtggggCgctgagtggactgcaaggtg	19	7	0	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:4638656C>T	ENST00000293778.6	-	4	928	c.506G>A	c.(505-507)cGc>cAc	p.R169H	CXCL16_ENST00000574412.1_Missense_Mutation_p.R169H|CXCL16_ENST00000576153.1_5'UTR	NM_022059.2	NP_071342.2	Q9H2A7	CXL16_HUMAN	chemokine (C-X-C motif) ligand 16	150					lymphocyte chemotaxis|positive regulation of cell growth|positive regulation of cell migration|receptor-mediated endocytosis|response to interferon-gamma|response to tumor necrosis factor	extracellular space|integral to membrane|plasma membrane	chemokine activity|low-density lipoprotein receptor activity|scavenger receptor activity			large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5						GAGGGTGGGGCGCTGAGTGGA	0.597													3	24					0	0	1	0	0	T	4638656	C	T	4638656	3	4	44	1	0	0	0	0	1	0	0	0	4106	768	27	1	323	1	CXCL16	17	4638656	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	3055687	4638656	76556554	118	4137										
TP53	7157	broad.mit.edu	37	chr17	7577534	7577534	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtgatgatggtgaggatgggCctccggttcatgccgcccat	15	10	1	3	rs28934571		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:7577534C>A	ENST00000420246.2	-	7	879	c.747G>T	c.(745-747)agG>agT	p.R249S	TP53_ENST00000455263.2_Missense_Mutation_p.R249S|TP53_ENST00000413465.2_Missense_Mutation_p.R249S|TP53_ENST00000445888.2_Missense_Mutation_p.R249S|TP53_ENST00000269305.4_Missense_Mutation_p.R249S|TP53_ENST00000359597.4_Missense_Mutation_p.R249S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	249	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in a sporadic cancer; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in sporadic cancers; somatic mutation; dbSNP:rs28934571).|R -> T (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(348)|p.0?(8)|p.R249R(5)|p.?(5)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R249_P250>SS(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*14(1)|p.R249_T256delRPILTIIT(1)|p.P250fs*14(1)|p.R249_I251delRPI(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAGGATGGGCCTCCGGTTCA	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	1					7.33628e-21	8.0564e-21	1	1	0	A	7577534	C	A	7577534	3	1	44	1	0	0	0	0	1	0	0	0	16441	738	26	5	543	5	TP53	17	7577534	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	2938878	7577534	73617676	119	4138										
SRCIN1	80725	broad.mit.edu	37	chr17	36707584	36707584	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atgtccttggcactgtactgGgtcagggctgcccgcttctc	12	13	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:36707584G>T	ENST00000264659.7	-	15	2993	c.2769C>A	c.(2767-2769)acC>acA	p.T923T	SRCIN1_ENST00000578925.1_Silent_p.T957T|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	795					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						CACTGTACTGGGTCAGGGCTG	0.617													20	20					1.96292e-10	2.07907e-10	1	1	0	T	36707584	G	T	36707584	2	4	44	1	0	0	0	0	0	0	0	1	15191	1219	43	5		5	SRCIN1	17	36707584	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	29130050	36707584	44487626	120	4139										
HELZ	9931	broad.mit.edu	37	chr17	65134211	65134211	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tccttcttaactcttctacaCgttccaccacttcaaacacc	1	17	4	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:65134211C>T	ENST00000358691.5	-	22	2955	c.2789G>A	c.(2788-2790)cGt>cAt	p.R930H	HELZ_ENST00000580168.1_Missense_Mutation_p.R931H	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTCTTCTACACGTTCCACCAC	0.368													48	2					0	0	1	0	0	T	65134211	C	T	65134211	3	4	44	1	0	0	0	0	1	0	0	0	7089	536	19	1	3087	1	HELZ	17	65134211	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	28426627	65134211	16060999	121	4140										
ATP5H	10476	broad.mit.edu	37	chr17	73036197	73036197	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aactacttacatcttcttttTcttcggcatccacctgggca	5	13	3	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:73036197T>C	ENST00000301587.4	-	4	328	c.281A>G	c.(280-282)gAa>gGa	p.E94G	KCTD2_ENST00000581589.1_Intron|ATP5H_ENST00000344546.4_Intron|KCTD2_ENST00000584767.1_Intron	NM_006356.2	NP_006347.1	O75947	ATP5H_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	94					ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			lung(1)|skin(1)	2	all_lung(278;0.226)					ATCTTCTTTTTCTTCGGCATC	0.408													124	80					0	0	1	0	0	C	73036197	T	C	73036197	3	2	44	1	0	0	0	0	1	0	0	0	1155	1783	62	4	216	4	ATP5H	17	73036197	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	7901986	73036197	8159013	122	4141										
KIAA0195	9772	broad.mit.edu	37	chr17	73492436	73492436	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	acgccaccagcatcagcatgGcccaggcctcggatggcctt	11	16	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:73492436G>A	ENST00000314256.7	+	24	3521	c.3127G>A	c.(3127-3129)Gcc>Acc	p.A1043T	KIAA0195_ENST00000579208.1_Missense_Mutation_p.A694T|KIAA0195_ENST00000375248.5_Missense_Mutation_p.A1053T	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1043					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CATCAGCATGGCCCAGGCCTC	0.617													15	131					0	0	1	0	0	A	73492436	G	A	73492436	3	1	44	1	0	0	0	0	1	0	0	0	8201	1203	42	3	3217	3	KIAA0195	17	73492436	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	456239	73492436	7702774	123	4142										
TYMS	7298	broad.mit.edu	37	chr18	672902	672902	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcccaaagctcaggattcttCgaaaagttgagaaaattgat	8	7	2	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:672902C>T	ENST00000323274.10	+	7	986	c.847C>T	c.(847-849)Cga>Tga	p.R283*	TYMS_ENST00000323250.5_Nonsense_Mutation_p.R200*|TYMS_ENST00000323224.7_Nonsense_Mutation_p.R249*|ENOSF1_ENST00000383578.3_3'UTR|TYMS_ENST00000581920.1_3'UTR|ENOSF1_ENST00000319815.6_3'UTR	NM_001071.2	NP_001062.1	P04818	TYSY_HUMAN	thymidylate synthetase	283					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity	p.R283*(1)		endometrium(1)|large_intestine(3)|lung(2)|urinary_tract(2)	8					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	CAGGATTCTTCGAAAAGTTGA	0.393													36	37					0	0	1	0	0	T	672902	C	T	672902	4	4	44	1	0	0	0	0	0	1	0	0	16873	876	31	1	873	1	TYMS	18	672902	Nonsense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08		672902	77404346	124	4143										
DSC2	1824	broad.mit.edu	37	chr18	28651725	28651725	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aatgaagtgacactagacatGccaagtctatctctcactgt	7	10	3	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:28651725G>A	ENST00000280904.6	-	13	2414	c.1971C>T	c.(1969-1971)ggC>ggT	p.G657G	DSC2_ENST00000251081.6_Silent_p.G657G	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	657	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CACTAGACATGCCAAGTCTAT	0.413													14	16					0	0	1	0	0	A	28651725	G	A	28651725	2	1	44	1	0	0	0	0	0	0	0	1	4792	1306	46	3		3	DSC2	18	28651725	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	27978823	28651725	49425523	125	4144										
ALPK2	115701	broad.mit.edu	37	chr18	56274661	56274661	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttataccaagttacctctggCttgggctgacctgacaataa	8	10	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:56274661C>T	ENST00000361673.3	-	3	333	c.120G>A	c.(118-120)aaG>aaA	p.K40K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	40	Ig-like 1.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTACCTCTGGCTTGGGCTGAC	0.348													16	18					0	0	1	0	0	T	56274661	C	T	56274661	2	4	44	1	0	0	0	0	0	0	0	1	541	796	28	3		3	ALPK2	18	56274661	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	27622936	56274661	21802587	126	4145										
SMARCA4	6597	broad.mit.edu	37	chr19	11141533	11141534	+	Frame_Shift_Del	DEL	TG	TG	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aacctccagtcggcagacacTgtgatcatttttgacagcga							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:11141533_11141534delTG	ENST00000358026.2	+	25	3794_3795	c.3510_3511delTG	c.(3508-3513)actgfs	p.TV1170fs	SMARCA4_ENST00000590574.1_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000541122.2_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000429416.3_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000444061.3_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000450717.3_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000589677.1_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000344626.4_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000413806.3_Frame_Shift_Del_p.TV1170fs	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1170	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGGCAGACACTGTGATCATTTT	0.599			"F, N, Mis"		NSCLC								9	1	---	---	---	---						-	11141534	TG	-	11141533	7	5	44	1	0	1	0	1	0	0	0	0	14823	1567	55	0	3604	0	SMARCA4	19	11141533	Frame_Shift_Del	DEL	TG	TCGA-NA-A4R1-01A-11D-A28R-08		11141533	47987450	127	4146										
ZNF536	9745	broad.mit.edu	37	chr19	31040264	31040264	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	caagcccaggaccccttggcGggcctgccaaagccggagcg	14	16	0	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:31040264G>A	ENST00000355537.3	+	4	3885	c.3738G>A	c.(3736-3738)gcG>gcA	p.A1246A		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.A1246A(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACCCCTTGGCGGGCCTGCCAA	0.632													36	20					0	0	1	0	0	A	31040264	G	A	31040264	2	1	44	1	0	0	0	0	0	0	0	1	18030	1103	39	1		1	ZNF536	19	31040264	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	19898731	31040264	28088719	128	4147										
FCGBP	8857	broad.mit.edu	37	chr19	40368843	40368843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tgaaatccgcccgtcggccaCggagacaggcaaggctgtga	14	12	0	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:40368843C>T	ENST00000221347.6	-	28	12512	c.12505G>A	c.(12505-12507)Gtg>Atg	p.V4169M		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4169	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCGTCGGCCACGGAGACAGGC	0.617													28	320					0	0	1	0	0	T	40368843	C	T	40368843	3	4	44	1	0	0	0	0	1	0	0	0	5810	536	19	1	3748	1	FCGBP	19	40368843	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	9328579	40368843	18760140	129	4148										
ZNF574	64763	broad.mit.edu	37	chr19	42584536	42584536	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcgttttcaccgtccttaccGcctgctcatgcaccgctacc	7	18	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:42584536G>A	ENST00000600245.1	+	2	2433	c.1778G>A	c.(1777-1779)cGc>cAc	p.R593H	ZNF574_ENST00000222339.7_Missense_Mutation_p.R683H|ZNF574_ENST00000359044.4_Missense_Mutation_p.R593H			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				CGTCCTTACCGCCTGCTCATG	0.612													41	86					0	0	1	0	0	A	42584536	G	A	42584536	3	1	44	1	0	0	0	0	1	0	0	0	18062	1087	38	1	1780	1	ZNF574	19	42584536	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	2215693	42584536	16544447	130	4149										
PRKD2	25865	broad.mit.edu	37	chr19	47207822	47207822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	agtggccactggccagagacGtggatgacaggcgccgtttg	16	10	0	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:47207822G>A	ENST00000433867.1	-	5	1073	c.596C>T	c.(595-597)aCg>aTg	p.T199M	PRKD2_ENST00000595515.1_Missense_Mutation_p.T199M|PRKD2_ENST00000600194.1_Missense_Mutation_p.T42M|PRKD2_ENST00000601806.1_Missense_Mutation_p.T42M|PRKD2_ENST00000291281.4_Missense_Mutation_p.T199M	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	199					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GGCCAGAGACGTGGATGACAG	0.667											OREG0025578	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	79					0	0	1	0	0	A	47207822	G	A	47207822	3	1	44	1	0	0	0	0	1	0	0	0	12570	1145	40	1	2100	1	PRKD2	19	47207822	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	4623286	47207822	11921161	131	4150										
BCAT2	587	broad.mit.edu	37	chr19	49303509	49303509	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gagccaggggcggaagaggcGcacctgctggtctttgcctt	16	11	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:49303509G>A	ENST00000402551.1	-	5	846	c.226C>T	c.(226-228)Cgc>Tgc	p.R76C	BCAT2_ENST00000545387.2_Missense_Mutation_p.R24C|BCAT2_ENST00000598162.1_Missense_Mutation_p.R116C|BCAT2_ENST00000597011.1_Missense_Mutation_p.R76C|BCAT2_ENST00000316273.6_Missense_Mutation_p.R116C|BCAT2_ENST00000599246.1_Missense_Mutation_p.R24C			O15382	BCAT2_HUMAN	branched chain amino-acid transaminase 2, mitochondrial	116						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	12		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	CGGAAGAGGCGCACCTGCTGG	0.657													19	99					0	0	1	0	0	A	49303509	G	A	49303509	3	1	44	1	0	0	0	0	1	0	0	0	1353	1087	38	1	864	1	BCAT2	19	49303509	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	2095687	49303509	9825474	132	4151										
MYBPC2	4606	broad.mit.edu	37	chr19	50963425	50963425	+	Frame_Shift_Del	DEL	A	A	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	atttcgtccagaaagcagacAaaaaaaccatggtgagagag							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:50963425delA	ENST00000357701.5	+	24	2971	c.2920delA	c.(2920-2922)aafs	p.K975fs		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	975	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GAAAGCAGACAAAAAAACCAT	0.592													7	23	---	---	---	---						-	50963425	A	-	50963425	7	5	44	1	0	1	0	1	0	0	0	0	10059	131	5	0	3014	0	MYBPC2	19	50963425	Frame_Shift_Del	DEL	A	TCGA-NA-A4R1-01A-11D-A28R-08	1659916	50963425	8165558	133	4152										
FPR3	2359	broad.mit.edu	37	chr19	52327267	52327267	+	Frame_Shift_Del	DEL	A	A	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ggtctcagtcgccatgagagAaaaatggccttttggctcat							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:52327267delA	ENST00000339223.4	+	2	445	c.266delA	c.(265-267)gafs	p.E89fs	FPR3_ENST00000595991.1_Frame_Shift_Del_p.E89fs	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	89					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						GCCATGAGAGAAAAATGGCCT	0.458													56	231	---	---	---	---						-	52327267	A	-	52327267	7	5	44	1	0	1	0	1	0	0	0	0	6073	246	9	0	268	0	FPR3	19	52327267	Frame_Shift_Del	DEL	A	TCGA-NA-A4R1-01A-11D-A28R-08	1363842	52327267	6801716	134	4153										
ZNF83	55769	broad.mit.edu	37	chr19	53116462	53116462	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	catttgaaaggtttctctccAgtgtgaattttccgatgatg	9	7	1	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:53116462A>G	ENST00000597597.1	-	2	3609	c.1356T>C	c.(1354-1356)acT>acC	p.T452T	ZNF83_ENST00000601257.1_Intron|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000544146.1_Silent_p.T452T|ZNF83_ENST00000541777.2_Silent_p.T452T|ZNF83_ENST00000536937.1_Silent_p.T452T|ZNF83_ENST00000545872.1_Silent_p.T452T|ZNF83_ENST00000301096.3_Silent_p.T452T|ZNF83_ENST00000391789.4_Silent_p.T424T			P51522	ZNF83_HUMAN	zinc finger protein 83	452						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		GTTTCTCTCCAGTGTGAATTT	0.388													41	211					0	0	1	0	0	G	53116462	A	G	53116462	2	3	44	1	0	0	0	0	0	0	0	1	18229	175	7	4		4	ZNF83	19	53116462	Silent	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	789195	53116462	6012521	135	4154										
ZNF71	58491	broad.mit.edu	37	chr19	57133398	57133398	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ctacgcgtgcggggactgcgGcaaggccttcagccagaaca	14	13	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:57133398G>A	ENST00000328070.6	+	3	977	c.743G>A	c.(742-744)gGc>gAc	p.G248D		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	248						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGGGACTGCGGCAAGGCCTTC	0.662													44	86					0	0	1	0	0	A	57133398	G	A	57133398	3	1	44	1	0	0	0	0	1	0	0	0	18169	1203	42	3	745	3	ZNF71	19	57133398	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	4016936	57133398	1995585	136	4155										
FOXA2	3170	broad.mit.edu	37	chr20	22563241	22563241	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ttgaaggagagcgagtggcgGatggagttctgccagcgctg	18	7	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:22563241G>C	ENST00000419308.2	-	2	823	c.621C>G	c.(619-621)atC>atG	p.I207M	FOXA2_ENST00000377115.4_Missense_Mutation_p.I207M|FOXA2_ENST00000319993.4_Missense_Mutation_p.I213M	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	207					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					GCGAGTGGCGGATGGAGTTCT	0.617													61	30					0	0	1	0	0	C	22563241	G	C	22563241	3	2	44	1	0	0	0	0	1	0	0	0	6022	1164	41	2	756	2	FOXA2	20	22563241	Missense_Mutation	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08		22563241	40462279	137	4156										
HNF4A	3172	broad.mit.edu	37	chr20	43043173	43043173	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tcccccgtctccgggatcaaCggcgacattcgggcgaagaa	12	14	2	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:43043173C>T	ENST00000316099.3	+	5	608	c.519C>T	c.(517-519)aaC>aaT	p.N173N	HNF4A_ENST00000415691.1_Silent_p.N173N|HNF4A_ENST00000443598.2_Silent_p.N173N|HNF4A_ENST00000457232.1_Silent_p.N151N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	173					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCGGGATCAACGGCGACATTC	0.582													25	47					0	0	1	0	0	T	43043173	C	T	43043173	2	4	44	1	0	0	0	0	0	0	0	1	7293	535	19	1		1	HNF4A	20	43043173	Silent	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	20479932	43043173	19982347	138	4157										
TUBB1	81027	broad.mit.edu	37	chr20	57599552	57599552	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ggtggctgtctgcgacatccCgccccgggggctgagcatgg	17	13	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:57599552C>T	ENST00000217133.1	+	4	1339	c.1070C>T	c.(1069-1071)cCg>cTg	p.P357L		NM_030773.3	NP_110400.1	Q9H4B7	TBB1_HUMAN	tubulin, beta 1 class VI	357					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|skin(2)	16	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	TGCGACATCCCGCCCCGGGGG	0.552													32	48					0	0	1	0	0	T	57599552	C	T	57599552	3	4	44	1	0	0	0	0	1	0	0	0	16814	652	23	1	1084	1	TUBB1	20	57599552	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	14556379	57599552	5425968	139	4158										
CDH26	60437	broad.mit.edu	37	chr20	58587675	58587675	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtggaggggccccatccctcAgctctctggccagcttggaa	13	14	2	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:58587675A>G	ENST00000348616.4	+	18	2689	c.2389A>G	c.(2389-2391)Agc>Ggc	p.S797G	CDH26_ENST00000244049.3_Missense_Mutation_p.S89G|CDH26_ENST00000497614.1_3'UTR|CDH26_ENST00000350849.6_Missense_Mutation_p.S130G|CDH26_ENST00000244047.5_Intron	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	256					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCCATCCCTCAGCTCTCTGGC	0.537													65	35					0	0	1	0	0	G	58587675	A	G	58587675	3	3	44	1	0	0	0	0	1	0	0	0	3132	188	7	4	2481	4	CDH26	20	58587675	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	988123	58587675	4437845	140	4159										
CHRNA4	1137	broad.mit.edu	37	chr20	61981956	61981956	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gtgatcttctcgccacactcGgagggcaggtagaagaccag	13	11	2	3			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:61981956G>A	ENST00000370263.4	-	5	1028	c.807C>T	c.(805-807)tcC>tcT	p.S269S	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	269					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGCCACACTCGGAGGGCAGGT	0.602													20	83					0	0	1	0	0	A	61981956	G	A	61981956	2	1	44	1	0	0	0	0	0	0	0	1	3407	1103	39	1		1	CHRNA4	20	61981956	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	3394281	61981956	1043564	141	4160										
BAGE2	85319	broad.mit.edu	37	chr21	11066363	11066363	+	RNA	DEL	T	T	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aatgaagcagagaggttaaaTttccttgttcaagtccatag					rs151040810		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr21:11066363delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agaggttaaatttccttgttc	0.294													3	6	---	---	---	---						-	11066363	T	-	11066363	6	5	44	0	1	1	0	1	0	0	0	0	1290	1508	52	0		0	BAGE2	21	11066363	RNA	DEL	T	TCGA-NA-A4R1-01A-11D-A28R-08		11066363	37063532	142	4161										
PFKL	5211	broad.mit.edu	37	chr21	45733884	45733885	+	Frame_Shift_Ins	INS	-	-	TG													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ggacggctgggagaacttcaINStgtgtgagaggctgggtgag							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr21:45733884_45733885insTG	ENST00000403390.1	+	8	868_869	c.868_869insTG	c.(868-870)gtgfs	p.V290fs	PFKL_ENST00000496824.1_3'UTR|PFKL_ENST00000349048.4_Frame_Shift_Ins_p.V243fs			P17858	K6PL_HUMAN	phosphofructokinase, liver	243					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GGAGAACTTCATGTGTGAGAGG	0.668													15	10	---	---	---	---						TG	45733885	-	TG	45733884	7	5	44	1	0	1	1	0	0	0	0	0	11811	217	8	0	753	0	PFKL	21	45733884	Frame_Shift_Ins	INS	-	TCGA-NA-A4R1-01A-11D-A28R-08	34667521	45733884	2396011	143	4162										
MICAL3	57553	broad.mit.edu	37	chr22	18324556	18324556	+	Frame_Shift_Del	DEL	C	C	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aggctcttagggccgtgtggCgggtgggcgccctgcagccc							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr22:18324556delC	ENST00000414725.2	-	20	2916	c.2917delG	c.(2917-2919)ccfs	p.A973fs	MICAL3_ENST00000383094.3_Frame_Shift_Del_p.A945fs|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000441493.2_Intron|MICAL3_ENST00000207726.7_Frame_Shift_Del_p.A973fs			Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	0	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		ggccgtgtggcgggtGGGCGC	0.662													2	4	---	---	---	---						-	18324556	C	-	18324556	7	5	44	1	0	1	0	1	0	0	0	0	9618	783	27	0		0	MICAL3	22	18324556	Frame_Shift_Del	DEL	C	TCGA-NA-A4R1-01A-11D-A28R-08		18324556	32980010	144	4163										
YY2	404281	broad.mit.edu	37	chrX	21875706	21875707	+	Frame_Shift_Ins	INS	-	-	A													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tattaacgcatgtgaagaccINSaaaaacaacccgtgaaaagg							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:21875706_21875707insA	ENST00000429584.2	+	1	1602_1603	c.1104_1105insA	c.(1102-1107)acaaaafs	p.TK368fs	MBTPS2_ENST00000365779.2_Intron|MBTPS2_ENST00000379484.5_Intron|MBTPS2_ENST00000465888.1_3'UTR	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	368	Mediates transcriptional repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						ATGTGAAGACCAAAAACAACCC	0.47													117	165	---	---	---	---						A	21875707	-	A	21875706	7	5	44	1	0	1	1	0	0	0	0	0	17568	581	21	0	1106	0	YY2	23	21875706	Frame_Shift_Ins	INS	-	TCGA-NA-A4R1-01A-11D-A28R-08		21875706	133394854	145	4164										
PHF16	0	broad.mit.edu	37	chrX	46913859	46913859	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gcagagctgggtatgcccacGctagctgtggactttatcta	12	10	1	1	rs140782937	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:46913859G>A	ENST00000218343.4	+	9	1570	c.1272G>A	c.(1270-1272)acG>acA	p.T424T	PHF16_ENST00000397189.1_Silent_p.T424T	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		424					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						GTATGCCCACGCTAGCTGTGG	0.493													15	68					0	0	1	0	0	A	46913859	G	A	46913859	2	1	44	1	0	0	0	0	0	0	0	1	11874	1074	38	1		1	PHF16	23	46913859	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	25038153	46913859	108356701	146	4165										
KIF4A	24137	broad.mit.edu	37	chrX	69607079	69607079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	aggatgctctccagaaacaaCgggaggttgcagataagcgg	14	8	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:69607079C>T	ENST00000374403.3	+	20	2246	c.2164C>T	c.(2164-2166)Cgg>Tgg	p.R722W	KIF4A_ENST00000374388.3_Missense_Mutation_p.R722W	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	722	Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						CCAGAAACAACGGGAGGTTGC	0.438													3	6					0	0	1	0	0	T	69607079	C	T	69607079	3	4	44	1	0	0	0	0	1	0	0	0	8344	527	19	1	2238	1	KIF4A	23	69607079	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	22693220	69607079	85663481	147	4166										
MED12	9968	broad.mit.edu	37	chrX	70344032	70344032	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	accctcgaagtgagagtgagCgggtggaattctttaactta	12	7	1	2			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:70344032C>T	ENST00000333646.6	+	13	1967	c.1768C>T	c.(1768-1770)Cgg>Tgg	p.R590W	MED12_ENST00000374080.3_Missense_Mutation_p.R590W|MED12_ENST00000374102.1_Missense_Mutation_p.R590W	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	590					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TGAGAGTGAGCGGGTGGAATT	0.473			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						22	29					0	0	1	0	0	T	70344032	C	T	70344032	3	4	44	1	0	0	0	0	1	0	0	0	9477	759	27	1	1818	1	MED12	23	70344032	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	736953	70344032	84926528	148	4167										
TMSB15B	286527	broad.mit.edu	37	chrX	103219162	103219162	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	caaaactgaagaaaactaatActgaagaaaaaaatactctt	4	6	1	4			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:103219162A>G	ENST00000567181.1	+	2	139	c.67A>G	c.(67-69)Act>Gct	p.T23A	TMSB15B_ENST00000569577.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000436583.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000563257.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000540220.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000419165.1_Missense_Mutation_p.T23A			P0CG34	TB15A_HUMAN	thymosin beta 15B	23					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding			skin(1)	1						GAAAACTAATACTGAAGAAAA	0.353													37	34					0	0	1	0	0	G	103219162	A	G	103219162	3	3	44	1	0	0	0	0	1	0	0	0	16315	391	14	4	69	4	TMSB15B	23	103219162	Missense_Mutation	SNP	A	TCGA-NA-A4R1-01A-11D-A28R-08	32875130	103219162	52051398	149	4168										
AMOT	154796	broad.mit.edu	37	chrX	112035202	112035202	+	Frame_Shift_Del	DEL	T	T	-													0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	tgtcaacgtacacttgcttcTttttcagctggaaatccatg							TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:112035202delT	ENST00000371959.3	-	6	1783	c.1784delA	c.(1783-1785)agfs	p.K596fs	AMOT_ENST00000371958.1_Frame_Shift_Del_p.K364fs|AMOT_ENST00000304758.1_Frame_Shift_Del_p.K187fs|AMOT_ENST00000524145.1_Frame_Shift_Del_p.K596fs|AMOT_ENST00000371962.1_Frame_Shift_Del_p.K364fs	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	596					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						CACTTGCTTCTTTTTCAGCTG	0.473													18	68	---	---	---	---						-	112035202	T	-	112035202	7	5	44	1	0	1	0	1	0	0	0	0	578	1609	56	0	1494	0	AMOT	23	112035202	Frame_Shift_Del	DEL	T	TCGA-NA-A4R1-01A-11D-A28R-08	8816040	112035202	43235358	150	4169										
MAGEA3	4102	broad.mit.edu	37	chrX	151935381	151935381	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	taacatgcaggatcactgccGgggacctgccggtactccag	12	13	1	0			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:151935381G>A	ENST00000393902.3	-	3	1353	c.786C>T	c.(784-786)ccC>ccT	p.P262P	MAGEA3_ENST00000370278.3_Silent_p.P262P			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	262	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					GATCACTGCCGGGGACCTGCC	0.527													59	179					0	0	1	0	0	A	151935381	G	A	151935381	2	1	44	1	0	0	0	0	0	0	0	1	9214	1103	39	1		1	MAGEA3	23	151935381	Silent	SNP	G	TCGA-NA-A4R1-01A-11D-A28R-08	39900179	151935381	3335179	151	4170										
MECP2	4204	broad.mit.edu	37	chrX	153296733	153296733	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	ccccggcctctgccagttccTggagctttgggagatttggg	14	12	1	1			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:153296733T>C	ENST00000407218.1	-	5	622	c.437A>G	c.(436-438)cAg>cGg	p.Q146R	MECP2_ENST00000303391.6_Silent_p.P182P|MECP2_ENST00000453960.2_Silent_p.P194P			P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	63	MBD.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAGTTCCTGGAGCTTTGG	0.602													5	213					0	0	1	0	0	C	153296733	T	C	153296733	3	2	44	1	0	0	0	0	1	0	0	0	9472	1567	55	4	918	4	MECP2	23	153296733	Missense_Mutation	SNP	T	TCGA-NA-A4R1-01A-11D-A28R-08	1361352	153296733	1973827	152	4171										
F8	2157	broad.mit.edu	37	chrX	154157053	154157053	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0130718954248366	2	1	0.171645194390605	0	0.173414732477106	0.333333333333333	1	0	gatctgactgaagagtagtaCgagttatttcccgttgatgg	12	6	1	4			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:154157053C>T	ENST00000360256.4	-	14	5212	c.5012G>A	c.(5011-5013)cGt>cAt	p.R1671H		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1671					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAGAGTAGTACGAGTTATTTC	0.408													42	43					0	0	1	0	0	T	154157053	C	T	154157053	3	4	44	1	0	0	0	0	1	0	0	0	5378	536	19	1	2123	1	F8	23	154157053	Missense_Mutation	SNP	C	TCGA-NA-A4R1-01A-11D-A28R-08	860320	154157053	1113507	153	4172										
ARID1A	8289	broad.mit.edu	37	chr1	27100870	27100870	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ggccctcctgccaagcggcaCgaaggggagatgtacagcgt	15	12	0	1	rs149908828	byFrequency	TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:27100870C>G	ENST00000324856.7	+	18	4523	c.4152C>G	c.(4150-4152)caC>caG	p.H1384Q	ARID1A_ENST00000374152.2_Missense_Mutation_p.H1001Q|ARID1A_ENST00000457599.2_Intron|ARID1A_ENST00000540690.1_Intron	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1384	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAAGCGGCACGAAGGGGAGA	0.597			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								3	37					0	0	1	0	0	G	27100870	C	G	27100870	3	3	45	1	0	0	0	0	1	0	0	0	910	535	19	5	4222	5	ARID1A	1	27100870	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		27100870	222149751	1	4173										
ZMYM1	79830	broad.mit.edu	37	chr1	35580612	35580612	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttattcagcatggtcttcacAgtaatattccttgtctctca	5	10	5	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:35580612A>G	ENST00000373330.1	+	11	3355	c.3181A>G	c.(3181-3183)Agt>Ggt	p.S1061G	ZMYM1_ENST00000359858.4_Missense_Mutation_p.S1061G|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	1061						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGGTCTTCACAGTAATATTCC	0.363													39	51					0	0	1	0	0	G	35580612	A	G	35580612	3	3	45	1	0	0	0	0	1	0	0	0	17756	188	7	4	3215	4	ZMYM1	1	35580612	Missense_Mutation	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08	8479742	35580612	213670009	2	4174										
COL24A1	255631	broad.mit.edu	37	chr1	86210421	86210421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	gttatctcgtgtgccaagagGattcttgatgctgtgcaata	11	7	2	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:86210421G>A	ENST00000370571.2	-	57	4966	c.4600C>T	c.(4600-4602)Cct>Tct	p.P1534S	COL24A1_ENST00000436319.1_Missense_Mutation_p.P1513S	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1534	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTGCCAAGAGGATTCTTGATG	0.393													16	37					0	0	1	0	0	A	86210421	G	A	86210421	3	1	45	1	0	0	0	0	1	0	0	0	3706	1174	41	3	560	3	COL24A1	1	86210421	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	50629809	86210421	163040200	3	4175										
FLG	2312	broad.mit.edu	37	chr1	152278698	152278698	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgtcctggctcacactggaTccctggcgcctgcttctcct	9	17	2	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:152278698T>G	ENST00000368799.1	-	3	8699	c.8664A>C	c.(8662-8664)ggA>ggC	p.G2888G	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2888	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCACACTGGATCCCTGGCGCC	0.567									Ichthyosis				106	325					0	0	1	0	0	G	152278698	T	G	152278698	2	3	45	1	0	0	0	0	0	0	0	1	5954	1422	50	4		4	FLG	1	152278698	Silent	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	66068277	152278698	96971923	4	4176										
FLG	2312	broad.mit.edu	37	chr1	152284533	152284533	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgtcctggctaacactggaTccctggcgcctgcttgtcct	10	15	0	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:152284533T>G	ENST00000368799.1	-	3	2864	c.2829A>C	c.(2827-2829)ggA>ggC	p.G943G	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	943	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAACACTGGATCCCTGGCGCC	0.567									Ichthyosis				10	454					0	0	1	0	0	G	152284533	T	G	152284533	2	3	45	1	0	0	0	0	0	0	0	1	5954	1422	50	4		4	FLG	1	152284533	Silent	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	5835	152284533	96966088	5	4177										
FLG2	388698	broad.mit.edu	37	chr1	152325750	152325750	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gagtgcacttcactgtcactGgactcactgtggccagatcc	10	13	3	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:152325750G>A	ENST00000388718.5	-	3	4584	c.4512C>T	c.(4510-4512)tcC>tcT	p.S1504S	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1504							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTGTCACTGGACTCACTGT	0.502													95	212					0	0	1	0	0	A	152325750	G	A	152325750	2	1	45	1	0	0	0	0	0	0	0	1	5955	1335	47	3		3	FLG2	1	152325750	Silent	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	41217	152325750	96924871	6	4178										
GPATCH2	55105	broad.mit.edu	37	chr1	217793423	217793423	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttttacctttctcctcctgcGcagagttctattcccaacat	4	14	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr1:217793423G>A	ENST00000366935.3	-	2	585	c.475C>T	c.(475-477)Cgc>Tgc	p.R159C	GPATCH2_ENST00000366934.3_Missense_Mutation_p.R159C	NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	159						intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		CTCCTCCTGCGCAGAGTTCTA	0.473													37	32					0	0	1	0	0	A	217793423	G	A	217793423	3	1	45	1	0	0	0	0	1	0	0	0	6630	1087	38	1	1147	1	GPATCH2	1	217793423	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	65467673	217793423	31457198	7	4179										
NCKAP5	344148	broad.mit.edu	37	chr2	133541232	133541232	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtggggtcccaagtgtttggCgaggagaggttttggggaca	19	5	0	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr2:133541232C>G	ENST00000409261.1	-	14	3525	c.3152G>C	c.(3151-3153)cGc>cCc	p.R1051P	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.R1051P|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1051							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AAGTGTTTGGCGAGGAGAGGT	0.557													33	47					0	0	1	0	0	G	133541232	C	G	133541232	3	3	45	1	0	0	0	0	1	0	0	0	10269	768	27	5	2605	5	NCKAP5	2	133541232	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		133541232	109658141	8	4180										
LCT	3938	broad.mit.edu	37	chr2	136567176	136567176	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cgccttcaatctgataagcgGaagaggacacgccccacaga	10	13	2	3			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr2:136567176G>T	ENST00000264162.2	-	8	2751	c.2741C>A	c.(2740-2742)tCc>tAc	p.S914Y		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	914	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTGATAAGCGGAAGAGGACAC	0.517													4	117					0.00909568	0.00909568	1	1	0	T	136567176	G	T	136567176	3	4	45	1	0	0	0	0	1	0	0	0	8731	1174	41	2	3082	2	LCT	2	136567176	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	3025944	136567176	106632197	9	4181										
LRP1B	53353	broad.mit.edu	37	chr2	142237984	142237984	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccctgacaatgtactccttcGtcatacccatctgggcagtc	7	15	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr2:142237984G>C	ENST00000389484.3	-	3	1295	c.324C>G	c.(322-324)gaC>gaG	p.D108E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	108	LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTACTCCTTCGTCATACCCAT	0.408										TSP Lung(27;0.18)			11	16					0	0	1	0	0	C	142237984	G	C	142237984	3	2	45	1	0	0	0	0	1	0	0	0	8999	1136	40	5	13831	5	LRP1B	2	142237984	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	5670808	142237984	100961389	10	4182										
ACVR1	90	broad.mit.edu	37	chr2	158594952	158594952	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgagaaactggcattcttacCgggtctgagaaccatctgtt	10	9	3	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr2:158594952C>T	ENST00000263640.3	-	10	1824	c.1395_splice	c.e10+1	p.P465_splice	ACVR1_ENST00000410057.2_Splice_Site_p.P465_splice|ACVR1_ENST00000409283.2_Splice_Site_p.P465_splice|ACVR1_ENST00000434821.1_Splice_Site_p.P465_splice	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	465	Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	GCATTCTTACCGGGTCTGAGA	0.433													21	80					0	0	1	0	0	T	158594952	C	T	158594952	5	4	45	1	0	0	0	0	0	0	1	0	219	666	23	1	142	1	ACVR1	2	158594952	Splice_Site	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08	16356968	158594952	84604421	11	4183										
LRP2	4036	broad.mit.edu	37	chr2	170025162	170025162	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cgaacatagtagcctggcagTatgcaccatcaggaaagcgt	11	10	1	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr2:170025162T>C	ENST00000263816.3	-	61	11807	c.11522A>G	c.(11521-11523)tAc>tGc	p.Y3841C		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3841	LDL-receptor class A 34.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGCCTGGCAGTATGCACCATC	0.428													3	30					0	0	1	0	0	C	170025162	T	C	170025162	3	2	45	1	0	0	0	0	1	0	0	0	9000	1638	57	4	2521	4	LRP2	2	170025162	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	11430210	170025162	73174211	12	4184										
DOCK10	55619	broad.mit.edu	37	chr2	225639777	225639777	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccttttcctcaaagaacggcGtcacataggtcacctggatg	9	12	3	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr2:225639777G>A	ENST00000409592.3	-	52	5953	c.5840C>T	c.(5839-5841)aCg>aTg	p.T1947M	DOCK10_ENST00000258390.7_Missense_Mutation_p.T1953M			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1953	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AAAGAACGGCGTCACATAGGT	0.493													15	23					0	0	1	0	0	A	225639777	G	A	225639777	3	1	45	1	0	0	0	0	1	0	0	0	4712	1145	40	1	722	1	DOCK10	2	225639777	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	55614615	225639777	17559596	13	4185										
LZTFL1	54585	broad.mit.edu	37	chr3	45877083	45877083	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	caagttcaaattttattaccGgttttcaagttcagagatgt	7	6	3	1	rs17856737		TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr3:45877083G>A	ENST00000296135.6	-	3	496	c.323_splice	c.e3+1	p.R108_splice	LZTFL1_ENST00000539217.1_Splice_Site_p.R104_splice|LZTFL1_ENST00000536047.1_Splice_Site_p.R91_splice|LZTFL1_ENST00000490463.1_5'UTR	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	108				R -> Q (in Ref. 4; AAH25988).						endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TTTTATTACCGGTTTTCAAGT	0.398													24	36					0	0	1	0	0	A	45877083	G	A	45877083	5	1	45	1	0	0	0	0	0	0	1	0	9181	1130	39	1	609	1	LZTFL1	3	45877083	Splice_Site	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		45877083	152145347	14	4186										
LEPREL1	55214	broad.mit.edu	37	chr3	189681862	189681862	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cagatgagaagctgatcatgCgcccacattttggttttata	9	8	1	3			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr3:189681862C>A	ENST00000319332.5	-	14	2116	c.1919G>T	c.(1918-1920)cGc>cTc	p.R640L	LEPREL1_ENST00000427335.2_Missense_Mutation_p.R459L	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	640	Fe2OG dioxygenase.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GCTGATCATGCGCCCACATTT	0.463													32	46					1.74807e-11	1.8413e-11	1	1	0	A	189681862	C	A	189681862	3	1	45	1	0	0	0	0	1	0	0	0	8768	768	27	5	215	5	LEPREL1	3	189681862	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08	143804779	189681862	8340568	15	4187										
SEC24B	10427	broad.mit.edu	37	chr4	110384637	110384637	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acagctatcagccatccatcGccacttccacctctaccatc	3	19	2	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr4:110384637G>A	ENST00000265175.5	+	2	769	c.714G>A	c.(712-714)tcG>tcA	p.S238S	SEC24B_ENST00000399100.2_Silent_p.S238S|SEC24B_ENST00000504968.2_Silent_p.S269S	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	238					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		GCCATCCATCGCCACTTCCAC	0.458													4	123					0	0	1	0	0	A	110384637	G	A	110384637	2	1	45	1	0	0	0	0	0	0	0	1	14048	1074	38	1		1	SEC24B	4	110384637	Silent	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		110384637	80769639	16	4188										
EGF	1950	broad.mit.edu	37	chr4	110866382	110866382	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccacttggtgaactgaaagtAgtgcatccacttgcacaacc	8	12	0	2	rs146585233	byFrequency	TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr4:110866382A>C	ENST00000265171.5	+	5	1336	c.891A>C	c.(889-891)gtA>gtC	p.V297V	EGF_ENST00000503392.1_Silent_p.V297V|EGF_ENST00000509793.1_Silent_p.V297V	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	297					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AACTGAAAGTAGTGCATCCAC	0.463													15	15					0	0	1	0	0	C	110866382	A	C	110866382	2	2	45	1	0	0	0	0	0	0	0	1	4988	407	15	4		4	EGF	4	110866382	Silent	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08	481745	110866382	80287894	17	4189										
PDGFRB	5159	broad.mit.edu	37	chr5	149498363	149498363	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aagcagcaccagctgggagaAggggggccgaatctcaaact	14	10	1	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr5:149498363A>T	ENST00000261799.4	-	21	3320	c.2851T>A	c.(2851-2853)Ttc>Atc	p.F951I		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	951	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGCTGGGAGAAGGGGGGCCGA	0.577			T	"ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"	"MPD, AML, CMML, CML"								26	96					0	0	1	0	0	T	149498363	A	T	149498363	3	4	45	1	0	0	0	0	1	0	0	0	11708	72	3	4	481	4	PDGFRB	5	149498363	Missense_Mutation	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08		149498363	31416897	18	4190										
IER3	8870	broad.mit.edu	37	chr6	30711931	30711931	+	Frame_Shift_Del	DEL	T	T	-													0	0	1	0	0	0	1	1	0	gagcagcagaaagagaagccTtttggctgggttcggttcct							TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr6:30711931delT	ENST00000376377.2	-	1	394	c.365delA	c.(364-366)agfs	p.K122fs	IER3_ENST00000259874.5_Frame_Shift_Del_p.R85fs			P46695	IEX1_HUMAN	immediate early response 3	0					anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding			NS(1)	1						AAGAGAAGCCTTTTGGCTGGG	0.627													95	113	---	---	---	---						-	30711931	T	-	30711931	7	5	45	1	0	1	0	1	0	0	0	0	7549	1608	56	0	221	0	IER3	6	30711931	Frame_Shift_Del	DEL	T	TCGA-NA-A5I1-01A-21D-A28R-08		30711931	140403136	19	4191										
DNAH8	1769	broad.mit.edu	37	chr6	38942307	38942307	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tttacactccactgtgcaggTaactgcagaaagcagttttc	8	10	0	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr6:38942307T>C	ENST00000359357.3	+	83	12437		c.e83+2		DNAH8_ENST00000441566.1_Splice_Site					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACTGTGCAGGTAACTGCAGAA	0.483													4	58					0	0	1	0	0	C	38942307	T	C	38942307	5	2	45	1	0	0	0	0	0	0	1	0	4634	1652	57	4	12507	4	DNAH8	6	38942307	Splice_Site	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	8230376	38942307	132172760	20	4192										
GOPC	57120	broad.mit.edu	37	chr6	117890850	117890850	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cgcatctatcagcaggttgcCccggatggatctcagagatg	12	11	3	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr6:117890850C>T	ENST00000535237.1	-	7	1191	c.962G>A	c.(961-963)gGg>gAg	p.G321E	GOPC_ENST00000467125.1_5'UTR|DCBLD1_ENST00000296955.8_3'UTR|GOPC_ENST00000368498.2_Missense_Mutation_p.G321E|GOPC_ENST00000052569.6_Missense_Mutation_p.G313E					golgi-associated PDZ and coiled-coil motif containing										GOPC/ROS1(14)	endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		AGCAGGTTGCCCCGGATGGAT	0.458			O	ROS1	glioblastoma								4	180					0	0	1	0	0	T	117890850	C	T	117890850	3	4	45	1	0	0	0	0	1	0	0	0	6611	623	22	3	438	3	GOPC	6	117890850	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08	78948543	117890850	53224217	21	4193										
CARD11	84433	broad.mit.edu	37	chr7	2987238	2987238	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgatcttggatggcagcataGgggcattaagcacttcatct	11	8	3	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr7:2987238G>A	ENST00000396946.4	-	3	594	c.191C>T	c.(190-192)cCt>cTt	p.P64L		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	64	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TGGCAGCATAGGGGCATTAAG	0.537			Mis		DLBCL								36	58					0	0	1	0	0	A	2987238	G	A	2987238	3	1	45	1	0	0	0	0	1	0	0	0	2663	1000	35	3	3365	3	CARD11	7	2987238	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		2987238	156151425	22	4194										
EPDR1	54749	broad.mit.edu	37	chr7	37989841	37989841	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctatacagtcaaggattgctAtcctgtccaggaaaccttta	7	10	1	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr7:37989841A>G	ENST00000199448.4	+	3	897	c.518A>G	c.(517-519)tAt>tGt	p.Y173C	EPDR1_ENST00000425345.1_Missense_Mutation_p.Y112C|EPDR1_ENST00000423717.1_3'UTR|EPDR1_ENST00000476620.1_Missense_Mutation_p.Y71C|EPDR1_ENST00000559325.1_Missense_Mutation_p.Y293C	NM_017549.4	NP_060019.2	Q9UM22	EPDR1_HUMAN	ependymin related 1	173					cell-matrix adhesion	extracellular region	calcium ion binding	p.Y293C(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						AAGGATTGCTATCCTGTCCAG	0.383													11	13					0	0	1	0	0	G	37989841	A	G	37989841	3	3	45	1	0	0	0	0	1	0	0	0	5191	449	16	4	888	4	EPDR1	7	37989841	Missense_Mutation	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08	35002603	37989841	121148822	23	4195										
MEPCE	56257	broad.mit.edu	37	chr7	100028470	100028470	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	accagcagcagcaggcagccGgagggagtgagagtcacccc	15	13	1	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr7:100028470G>A	ENST00000310512.2	+	1	1217	c.829G>A	c.(829-831)Gga>Aga	p.G277R	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	277							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAGGCAGCCGGAGGGAGTGA	0.662													4	154					0	0	1	0	0	A	100028470	G	A	100028470	3	1	45	1	0	0	0	0	1	0	0	0	9526	1117	39	1	831	1	MEPCE	7	100028470	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	62038629	100028470	59110193	24	4196										
CLCN1	1180	broad.mit.edu	37	chr7	143049003	143049003	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ggagctggccgacatcttgcAgggccccagcctgcgatcca	13	15	1	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr7:143049003A>T	ENST00000343257.2	+	23	2999	c.2912A>T	c.(2911-2913)cAg>cTg	p.Q971L		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	971					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GACATCTTGCAGGGCCCCAGC	0.637													48	10					0	0	1	0	0	T	143049003	A	T	143049003	3	4	45	1	0	0	0	0	1	0	0	0	3485	188	7	4	3002	4	CLCN1	7	143049003	Missense_Mutation	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08	43020533	143049003	16089660	25	4197										
TRPS1	7227	broad.mit.edu	37	chr8	116430678	116430678	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aaaacaccggagcctctacgCctctgaaacaggggaaaaaa	9	11	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr8:116430678C>A	ENST00000395715.3	-	6	3280	c.2703G>T	c.(2701-2703)agG>agT	p.R901S	TRPS1_ENST00000520276.1_Missense_Mutation_p.R892S|TRPS1_ENST00000519076.1_Missense_Mutation_p.R642S|TRPS1_ENST00000220888.5_Missense_Mutation_p.R888S	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	888			T -> P (in TRPS3; severe).		negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R888R(2)|p.R901R(2)		autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGCCTCTACGCCTCTGAAACA	0.473									Langer-Giedion syndrome				6	181					2.7689e-08	2.87819e-08	1	1	0	A	116430678	C	A	116430678	3	1	45	1	0	0	0	0	1	0	0	0	16653	738	26	5	1189	5	TRPS1	8	116430678	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		116430678	29933344	26	4198										
DOCK8	81704	broad.mit.edu	37	chr9	368135	368135	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gatgctagcaatgcgatgccGgtaaggagggaaacgaacat	14	7	0	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr9:368135G>A	ENST00000432829.2	+	15	1909	c.1593_splice	c.e15+1	p.P531_splice	DOCK8_ENST00000382331.1_5'UTR|DOCK8_ENST00000469391.1_Splice_Site_p.P531_splice|DOCK8_ENST00000382329.1_Silent_p.P11P|DOCK8_ENST00000453981.1_Splice_Site_p.P599_splice	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	599	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ATGCGATGCCGGTAAGGAGGG	0.478													5	87					0	0	1	0	0	A	368135	G	A	368135	5	1	45	1	0	0	0	0	0	0	1	0	4720	1130	39	1	1855	1	DOCK8	9	368135	Splice_Site	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		368135	140845296	27	4199										
PFKP	5214	broad.mit.edu	37	chr10	3162118	3162118	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cctggagctgtcagccgcccGggagaagcacgaggagttct	15	12	2	1	rs140443512		TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr10:3162118G>C	ENST00000381075.2	+	18	1765	c.1541G>C	c.(1540-1542)cGg>cCg	p.R514P	PFKP_ENST00000381125.4_Missense_Mutation_p.R522P	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	522					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		TCAGCCGCCCGGGAGAAGCAC	0.632											OREG0019976	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	77					0	0	1	0	0	C	3162118	G	C	3162118	3	2	45	1	0	0	0	0	1	0	0	0	11813	1116	39	5	1627	5	PFKP	10	3162118	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		3162118	132372629	28	4200										
OR51A2	401667	broad.mit.edu	37	chr11	4976601	4976601	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tgacatgatcaggaggactgAggactccagtactgagaatc	12	8	1	4			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr11:4976601A>G	ENST00000380371.1	-	1	342	c.343T>C	c.(343-345)Tca>Cca	p.S115P	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGAGGACTGAGGACTCCAGT	0.453													4	68					0	0	1	0	0	G	4976601	A	G	4976601	3	3	45	1	0	0	0	0	1	0	0	0	11133	304	11	4	600	4	OR51A2	11	4976601	Missense_Mutation	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08		4976601	130029915	29	4201										
NLRP10	338322	broad.mit.edu	37	chr11	7984813	7984813	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acaggttcatgaccttcaagCccttgaggacaactttcaca	7	12	3	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr11:7984813C>T	ENST00000328600.2	-	1	391	c.230G>A	c.(229-231)gGc>gAc	p.G77D		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	77	DAPIN.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GACCTTCAAGCCCTTGAGGAC	0.542													35	4					0	0	1	0	0	T	7984813	C	T	7984813	3	4	45	1	0	0	0	0	1	0	0	0	10518	739	26	3	1745	3	NLRP10	11	7984813	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08	3008212	7984813	127021703	30	4202										
INSC	387755	broad.mit.edu	37	chr11	15260618	15260618	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	acgggaggccgtgcggctcaGctgtgagtggtgctttctgg	18	9	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr11:15260618G>C	ENST00000379554.3	+	11	1578	c.1532G>C	c.(1531-1533)aGc>aCc	p.S511T	INSC_ENST00000379556.3_Missense_Mutation_p.S464T|INSC_ENST00000525218.1_Missense_Mutation_p.S422T|INSC_ENST00000530161.1_Missense_Mutation_p.S464T|INSC_ENST00000424273.1_Missense_Mutation_p.S422T|INSC_ENST00000447214.2_3'UTR|INSC_ENST00000528567.1_Missense_Mutation_p.S464T	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	511					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						GTGCGGCTCAGCTGTGAGTGG	0.617													16	19					0	0	1	0	0	C	15260618	G	C	15260618	3	2	45	1	0	0	0	0	1	0	0	0	7807	971	34	5	1574	5	INSC	11	15260618	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	7275805	15260618	119745898	31	4203										
AHNAK	79026	broad.mit.edu	37	chr11	62291941	62291941	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttaatgtcaccttccaacttGggcccagagacatcaacatc	6	13	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr11:62291941G>C	ENST00000378024.4	-	5	10222	c.9948C>G	c.(9946-9948)ccC>ccG	p.P3316P	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3316					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTCCAACTTGGGCCCAGAGA	0.443													26	22					0	0	1	0	0	C	62291941	G	C	62291941	2	2	45	1	0	0	0	0	0	0	0	1	411	1335	47	5		5	AHNAK	11	62291941	Silent	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	47031323	62291941	72714575	32	4204										
UNC93B1	81622	broad.mit.edu	37	chr11	67763096	67763096	+	Frame_Shift_Del	DEL	T	T	-													0	0	1	0	0	0	1	1	0	actcactgctgagtccagtcTtgttcagggcactgcccaca							TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr11:67763096delT	ENST00000227471.2	-	10	1425	c.1346delA	c.(1345-1347)agfs	p.K449fs	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	450					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											GAGTCCAGTCTTGTTCAGGGC	0.602													2	4	---	---	---	---						-	67763096	T	-	67763096	7	5	45	1	0	1	0	1	0	0	0	0	17056	1609	56	0	456	0	UNC93B1	11	67763096	Frame_Shift_Del	DEL	T	TCGA-NA-A5I1-01A-21D-A28R-08	5471155	67763096	67243420	33	4205										
APOBEC1	339	broad.mit.edu	37	chr12	7805124	7805124	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	atccatgtgccaaaaaagccGagctacgtagatcactagag	9	10	1	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr12:7805124G>A	ENST00000229304.4	-	3	372	c.352C>T	c.(352-354)Cgg>Tgg	p.R118W		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	118					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CAAAAAAGCCGAGCTACGTAG	0.483													31	30					0	0	1	0	0	A	7805124	G	A	7805124	3	1	45	1	0	0	0	0	1	0	0	0	784	1057	37	1	370	1	APOBEC1	12	7805124	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		7805124	126046771	34	4206										
ITGA7	3679	broad.mit.edu	37	chr12	56078974	56078976	+	In_Frame_Del	DEL	CTC	CTC	-													0	0	1	0	0	0	1	1	0	ctcaggatggtgcccgtcttCtcctccttgaactgctgtcg							TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr12:56078974_56078976delCTC	ENST00000257879.6	-	25	3495_3497	c.3280_3282delGAG	c.(3280-3282)del	p.E1094del	ITGA7_ENST00000257880.7_3'UTR|ITGA7_ENST00000553804.1_In_Frame_Del_p.E1098del|ITGA7_ENST00000452168.2_In_Frame_Del_p.E1001del|ITGA7_ENST00000394230.2_3'UTR|ITGA7_ENST00000394229.2_3'UTR|ITGA7_ENST00000347027.6_In_Frame_Del_p.E1088del|ITGA7_ENST00000555728.1_In_Frame_Del_p.E1138del	NM_002206.2	NP_002197.2	Q13683	ITA7_HUMAN	integrin, alpha 7	1138					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TGCCCGTCTTCTCCTCCTTGAAC	0.645													33	43	---	---	---	---						-	56078976	CTC	-	56078974	7	5	45	1	0	1	0	1	0	0	0	0	7924	912	32	0	135	0	ITGA7	12	56078974	In_Frame_Del	DEL	CTC	TCGA-NA-A5I1-01A-21D-A28R-08	48273850	56078974	77772921	35	4207										
ANKRD52	283373	broad.mit.edu	37	chr12	56638535	56638535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttgatgctgcagcagcatccGgagcccagagacattgtccg	12	12	0	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr12:56638535G>A	ENST00000267116.7	-	24	2744	c.2623C>T	c.(2623-2625)Cgg>Tgg	p.R875W		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	875							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						AGCAGCATCCGGAGCCCAGAG	0.607													37	104					0	0	1	0	0	A	56638535	G	A	56638535	3	1	45	1	0	0	0	0	1	0	0	0	672	1115	39	1	627	1	ANKRD52	12	56638535	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	559561	56638535	77213360	36	4208										
PTPRB	0	broad.mit.edu	37	chr12	70963618	70963618	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctgtgcctgaatgccgacacCgtgtaggaatcaacgtctcc	10	13	2	1	rs61757802		TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr12:70963618C>A	ENST00000334414.6	-	14	3515	c.3471G>T	c.(3469-3471)acG>acT	p.T1157T	PTPRB_ENST00000538708.1_Silent_p.T939T|PTPRB_ENST00000550358.1_Silent_p.T1069T|PTPRB_ENST00000551525.1_Silent_p.T1156T|PTPRB_ENST00000550857.1_Silent_p.T849T|PTPRB_ENST00000451516.2_Silent_p.T849T|PTPRB_ENST00000261266.5_Silent_p.T939T	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	939	Fibronectin type-III 13.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGCCGACACCGTGTAGGAAT	0.517													19	33					8.10497e-08	8.31549e-08	1	1	0	A	70963618	C	A	70963618	2	1	45	1	0	0	0	0	0	0	0	1	12847	639	23	5		5	PTPRB	12	70963618	Silent	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08	14325083	70963618	62888277	37	4209										
TDRD9	122402	broad.mit.edu	37	chr14	104491922	104491922	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tggttgaagtgggacactttTggggatacaggattgatgaa	15	3	0	3			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr14:104491922T>G	ENST00000409874.4	+	26	2788	c.2740T>G	c.(2740-2742)Tgg>Ggg	p.W914G	TDRD9_ENST00000339063.5_Missense_Mutation_p.W914G	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	914					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				GGGACACTTTTGGGGATACAG	0.443													19	44					0	0	1	0	0	G	104491922	T	G	104491922	3	3	45	1	0	0	0	0	1	0	0	0	15794	1812	63	4	2842	4	TDRD9	14	104491922	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08		104491922	2857618	38	4210										
AHNAK2	113146	broad.mit.edu	37	chr14	105416359	105416359	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0	0	1	0	0	0	1	1	0	tcacatccttgtcggccaggGacaggtcaccctccagccgc	10	17	2	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr14:105416359G>C	ENST00000333244.5	-	7	5548	c.5429C>G	c.(5428-5430)tCc>tGc	p.S1810C	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1810						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCGGCCAGGGACAGGTCACC	0.617													9	632					0	0	1	0	0	C	105416359	G	C	105416359	3	2	45	1	0	0	0	0	1	0	0	0	412	1174	41	2	11962	2	AHNAK2	14	105416359	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	924437	105416359	1933181	39	4211										
SCNN1B	0	broad.mit.edu	37	chr16	23366760	23366760	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gtagagatgagctaccccggCgagcagatgatcctggcctg	14	11	0	4	rs148125384		TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr16:23366760C>G	ENST00000343070.2	+	4	902	c.726C>G	c.(724-726)ggC>ggG	p.G242G	SCNN1B_ENST00000307331.5_Silent_p.G287G|SCNN1B_ENST00000568085.1_Silent_p.G242G|SCNN1B_ENST00000568923.1_Silent_p.G215G	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	242					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	GCTACCCCGGCGAGCAGATGA	0.617													37	3					0	0	1	0	0	G	23366760	C	G	23366760	2	3	45	1	0	0	0	0	0	0	0	1	13981	755	27	5		5	SCNN1B	16	23366760	Silent	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		23366760	66987993	40	4212										
CNOT1	23019	broad.mit.edu	37	chr16	58565875	58565875	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gccacaccttctgctgtggcGtatgtgccagcattcttgca	10	13	2	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr16:58565875G>C	ENST00000317147.5	-	42	6496	c.6164C>G	c.(6163-6165)aCg>aGg	p.T2055R	CNOT1_ENST00000245138.4_Missense_Mutation_p.T906R|CNOT1_ENST00000569240.1_Missense_Mutation_p.T2050R	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2055					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CTGCTGTGGCGTATGTGCCAG	0.423													34	4					0	0	1	0	0	C	58565875	G	C	58565875	3	2	45	1	0	0	0	0	1	0	0	0	3640	1145	40	5	998	5	CNOT1	16	58565875	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	35199115	58565875	31788878	41	4213										
LRRC36	55282	broad.mit.edu	37	chr16	67404868	67404868	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tctgtatgccacaacccattTcaacagtgaccctgctgtac	6	14	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr16:67404868T>A	ENST00000329956.6	+	9	1236	c.1217T>A	c.(1216-1218)tTc>tAc	p.F406Y	LRRC36_ENST00000563189.1_Missense_Mutation_p.F285Y|LRRC36_ENST00000541146.1_5'UTR|LRRC36_ENST00000435835.3_Missense_Mutation_p.F285Y|LRRC36_ENST00000290940.7_Missense_Mutation_p.F138Y	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	406										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		ACAACCCATTTCAACAGTGAC	0.473													148	7					0	0	1	0	0	A	67404868	T	A	67404868	3	1	45	1	0	0	0	0	1	0	0	0	9034	1783	62	4	1279	4	LRRC36	16	67404868	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	8838993	67404868	22949885	42	4214										
SLC16A13	201232	broad.mit.edu	37	chr17	6941536	6941536	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cctgttatttctctcgccgaCgatccctggccaccgggctg	10	16	1	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr17:6941536C>G	ENST00000308027.6	+	3	717	c.409C>G	c.(409-411)Cga>Gga	p.R137G		NM_201566.2	NP_963860.1	Q7RTY0	MOT13_HUMAN	solute carrier family 16, member 13	137						integral to membrane|plasma membrane	symporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						CTCTCGCCGACGATCCCTGGC	0.597													44	7					0	0	1	0	0	G	6941536	C	G	6941536	3	3	45	1	0	0	0	0	1	0	0	0	14460	528	19	5	419	5	SLC16A13	17	6941536	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		6941536	74253674	43	4215										
DHX8	1659	broad.mit.edu	37	chr17	41582141	41582141	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aaagacccagatgtcaatccTtgagcagagggagagcctgc	12	10	1	5			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr17:41582141T>A	ENST00000262415.3	+	12	1748	c.1676T>A	c.(1675-1677)cTt>cAt	p.L559H	DHX8_ENST00000540306.1_Missense_Mutation_p.L559H	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	559						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ATGTCAATCCTTGAGCAGAGG	0.473													163	71					0	0	1	0	0	A	41582141	T	A	41582141	3	1	45	1	0	0	0	0	1	0	0	0	4543	1609	56	4	1722	4	DHX8	17	41582141	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	34640605	41582141	39613069	44	4216										
SPOP	8405	broad.mit.edu	37	chr17	47696599	47696599	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aagaggagaacatttacccaTagctttggtttcttctccct	7	10	2	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr17:47696599T>C	ENST00000393331.3	-	6	819	c.349A>G	c.(349-351)Atg>Gtg	p.M117V	SPOP_ENST00000347630.2_Missense_Mutation_p.M117V|SPOP_ENST00000504102.1_Missense_Mutation_p.M117V|SPOP_ENST00000503676.1_Missense_Mutation_p.M117V|SPOP_ENST00000393328.2_Missense_Mutation_p.M117V	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	117	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.M117V(2)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CATTTACCCATAGCTTTGGTT	0.413										Prostate(2;0.17)			26	41					0	0	1	0	0	C	47696599	T	C	47696599	3	2	45	1	0	0	0	0	1	0	0	0	15139	1406	49	4	803	4	SPOP	17	47696599	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	6114458	47696599	33498611	45	4217										
ITGA3	3675	broad.mit.edu	37	chr17	48165680	48165680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ccagccgtcagagacagagaGgctgaccgacgactactgag	13	12	1	4			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr17:48165680G>A	ENST00000320031.8	+	25	3467	c.3137G>A	c.(3136-3138)aGg>aAg	p.R1046K	ITGA3_ENST00000007722.7_Intron	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	1046					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						GAGACAGAGAGGCTGACCGAC	0.697													7	7					0	0	1	0	0	A	48165680	G	A	48165680	3	1	45	1	0	0	0	0	1	0	0	0	7920	1000	35	3	3235	3	ITGA3	17	48165680	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	469081	48165680	33029530	46	4218										
DNAH17	8632	broad.mit.edu	37	chr17	76490147	76490147	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gccgctgcccgcattcccgaCgatgaacacggagtggcgga	14	14	0	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr17:76490147C>T	ENST00000389840.5	-	41	6461	c.6337G>A	c.(6337-6339)Gtc>Atc	p.V2113I	DNAH17_ENST00000585328.1_Missense_Mutation_p.V2122I|RP11-559N14.5_ENST00000585969.1_RNA|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCATTCCCGACGATGAACACG	0.662													11	5					0	0	1	0	0	T	76490147	C	T	76490147	3	4	45	1	0	0	0	0	1	0	0	0	4629	536	19	1	7173	1	DNAH17	17	76490147	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08	28324467	76490147	4705063	47	4219										
DTNA	1837	broad.mit.edu	37	chr18	32428344	32428344	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctggcagcagagtcctcttcGtctgtaagtagttggagtaa	12	8	2	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr18:32428344G>C	ENST00000283365.9	+	13	1530	c.1179G>C	c.(1177-1179)tcG>tcC	p.S393S	DTNA_ENST00000597674.1_Silent_p.S72S|DTNA_ENST00000269191.6_Silent_p.S450S|DTNA_ENST00000591182.1_Silent_p.S98S|DTNA_ENST00000556414.3_Silent_p.S102S|DTNA_ENST00000599844.1_Silent_p.S72S|DTNA_ENST00000598334.1_Silent_p.S390S|DTNA_ENST00000601125.1_Silent_p.S72S|DTNA_ENST00000348997.5_Silent_p.S447S|DTNA_ENST00000598142.1_Silent_p.S393S|DTNA_ENST00000399097.3_Silent_p.S98S|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000598774.1_Silent_p.S393S|DTNA_ENST00000597599.1_Silent_p.S390S|DTNA_ENST00000444659.1_Silent_p.S450S|DTNA_ENST00000595022.1_Silent_p.S390S|DTNA_ENST00000399121.5_Silent_p.S390S|DTNA_ENST00000269190.7_Silent_p.S451S|DTNA_ENST00000399113.3_Silent_p.S450S|DTNA_ENST00000269192.7_Silent_p.S159S	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	450					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						AGTCCTCTTCGTCTGTAAGTA	0.428													16	13					0	0	1	0	0	C	32428344	G	C	32428344	2	2	45	1	0	0	0	0	0	0	0	1	4814	1132	40	5		5	DTNA	18	32428344	Silent	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		32428344	45648904	48	4220										
PDCD5	9141	broad.mit.edu	37	chr19	33077794	33077794	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	aaggtttaatagaaatccttAaaaaagtaagccaacaaaca	5	6	0	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr19:33077794A>T	ENST00000590247.1	+	5	483	c.289A>T	c.(289-291)Aaa>Taa	p.K97*	PDCD5_ENST00000379316.3_Intron|PDCD5_ENST00000586035.1_Nonsense_Mutation_p.K59*|PDCD5_ENST00000592786.1_Nonstop_Mutation_p.*66L	NM_004708.3	NP_004699.1	O14737	PDCD5_HUMAN	programmed cell death 5	97					apoptosis|induction of apoptosis	cytoplasm|nucleus	DNA binding			breast(1)|large_intestine(2)|lung(1)|ovary(1)	5	Esophageal squamous(110;0.137)					AGAAATCCTTAAAAAAGTAAG	0.323													25	53					0	0	1	0	0	T	33077794	A	T	33077794	4	4	45	1	0	0	0	0	0	1	0	0	11668	363	13	4	307	4	PDCD5	19	33077794	Nonsense_Mutation	SNP	A	TCGA-NA-A5I1-01A-21D-A28R-08		33077794	26051189	49	4221										
SULT2A1	6822	broad.mit.edu	37	chr19	48382317	48382317	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttcagctcctcataactcagTaacaggaagtttttctcctc	5	12	4	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr19:48382317T>A	ENST00000222002.3	-	4	682	c.543A>T	c.(541-543)ttA>ttT	p.L181F		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	181					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		CATAACTCAGTAACAGGAAGT	0.463													20	186					0	0	1	0	0	A	48382317	T	A	48382317	3	1	45	1	0	0	0	0	1	0	0	0	15436	1635	57	4	326	4	SULT2A1	19	48382317	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	15304523	48382317	10746666	50	4222										
HSPBP1	23640	broad.mit.edu	37	chr19	55789014	55789014	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	gggggaagcggggtacctgcGgcattgtccatgttctcaca	15	10	1	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr19:55789014G>A	ENST00000255631.5	-	4	721	c.411C>T	c.(409-411)gcC>gcT	p.A137A	HSPBP1_ENST00000433386.2_Silent_p.A137A|HSPBP1_ENST00000376343.3_Silent_p.A137A|HSPBP1_ENST00000587922.1_Silent_p.A137A	NM_001130106.1|NM_012267.4	NP_001123578.1|NP_036399.3	Q9NZL4	HPBP1_HUMAN	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	140					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGGTACCTGCGGCATTGTCCA	0.672													7	16					0	0	1	0	0	A	55789014	G	A	55789014	2	1	45	1	0	0	0	0	0	0	0	1	7469	1103	39	1		1	HSPBP1	19	55789014	Silent	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	7406697	55789014	3339969	51	4223										
CTCFL	140690	broad.mit.edu	37	chr20	56093864	56093864	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tttaaagggtttctcatgagTatgtttatagcgcctgtgtc	10	6	1	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr20:56093864T>C	ENST00000426658.2	-	4	1670	c.1009A>G	c.(1009-1011)Act>Gct	p.T337A	CTCFL_ENST00000481655.1_5'UTR|CTCFL_ENST00000371196.2_Missense_Mutation_p.T337A|CTCFL_ENST00000422109.2_Missense_Mutation_p.T337A|CTCFL_ENST00000502686.2_Missense_Mutation_p.T75A|CTCFL_ENST00000432255.2_Missense_Mutation_p.T337A|CTCFL_ENST00000423479.2_Missense_Mutation_p.T337A|CTCFL_ENST00000433949.2_Missense_Mutation_p.T337A|CTCFL_ENST00000243914.3_Missense_Mutation_p.T337A|CTCFL_ENST00000422869.2_Missense_Mutation_p.T337A|CTCFL_ENST00000539382.1_Missense_Mutation_p.T132A|CTCFL_ENST00000429804.2_Missense_Mutation_p.T337A			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	337					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TTCTCATGAGTATGTTTATAG	0.458													65	53					0	0	1	0	0	C	56093864	T	C	56093864	3	2	45	1	0	0	0	0	1	0	0	0	4025	1638	57	4	1010	4	CTCFL	20	56093864	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08		56093864	6931656	52	4224										
COL20A1	57642	broad.mit.edu	37	chr20	61959791	61959791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cctggggtcccctggcacccGcagcaaggccctggttcctg	13	17	0	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr20:61959791G>A	ENST00000422202.1	+	33	3829	c.3761G>A	c.(3760-3762)cGc>cAc	p.R1254H	COL20A1_ENST00000435874.1_Missense_Mutation_p.R1254H|COL20A1_ENST00000358894.6_Missense_Mutation_p.R1241H|COL20A1_ENST00000326996.6_Missense_Mutation_p.R1273H			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1241					cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CCTGGCACCCGCAGCAAGGCC	0.662													13	21					0	0	1	0	0	A	61959791	G	A	61959791	3	1	45	1	0	0	0	0	1	0	0	0	3702	1087	38	1	3794	1	COL20A1	20	61959791	Missense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	5865927	61959791	1065729	53	4225										
KRTAP10-7	386675	broad.mit.edu	37	chr21	46021513	46021513	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cacctgctgcgtgcccgtccCctcctgctgcgcccccacct	8	23	0	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr21:46021513C>A	ENST00000380102.2	+	1	1017	c.992C>A	c.(991-993)cCc>cAc	p.P331H	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	331	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						GTGCCCGTCCCCTCCTGCTGC	0.721													11	154					6.40141e-05	6.48348e-05	1	1	0	A	46021513	C	A	46021513	3	1	45	1	0	0	0	0	1	0	0	0	8556	623	22	5	983	5	KRTAP10-7	21	46021513	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		46021513	2108382	54	4226										
P2RX6	9127	broad.mit.edu	37	chr22	21377577	21377577	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ctcccaggtccaatgccttgGagacctgggaccccacctat	9	16	0	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chr22:21377577G>T	ENST00000413302.2	+	7	800	c.652G>T	c.(652-654)Gag>Tag	p.E218*	P2RX6_ENST00000401443.1_Nonsense_Mutation_p.E192*|P2RX6_ENST00000402329.3_3'UTR|P2RX6_ENST00000443995.3_Nonsense_Mutation_p.E165*|P2RX6_ENST00000336296.2_Nonsense_Mutation_p.E208*			O15547	P2RX6_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 6	218					muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity										CAATGCCTTGGAGACCTGGGA	0.562													90	10					5.92634e-42	6.41343e-42	1	1	0	T	21377577	G	T	21377577	4	4	45	1	0	0	0	0	0	1	0	0	11390	1175	41	2	678	2	P2RX6	22	21377577	Nonsense_Mutation	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08		21377577	29926989	55	4227										
ACE2	59272	broad.mit.edu	37	chrX	15609873	15609873	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tcatttttcaagaccacataCtcttcatataatggcctcag	4	11	5	1			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chrX:15609873C>A	ENST00000427411.1	-	5	762	c.546G>T	c.(544-546)gaG>gaT	p.E182D	ACE2_ENST00000252519.3_Missense_Mutation_p.E182D	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	182					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	AGACCACATACTCTTCATATA	0.463													184	221					5.92754e-76	6.50383e-76	1	1	0	A	15609873	C	A	15609873	3	1	45	1	0	0	0	0	1	0	0	0	137	564	20	5	1931	5	ACE2	23	15609873	Missense_Mutation	SNP	C	TCGA-NA-A5I1-01A-21D-A28R-08		15609873	139660687	56	4228										
IRS4	8471	broad.mit.edu	37	chrX	107976057	107976057	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	cttgggctccccttactgctTcggcatcagcagcattagca	9	14	1	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chrX:107976057T>A	ENST00000372129.2	-	1	3594	c.3518A>T	c.(3517-3519)gAa>gTa	p.E1173V		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	1173	Ala-rich.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CCTTACTGCTTCGGCATCAGC	0.637													106	134					0	0	1	0	0	A	107976057	T	A	107976057	3	1	45	1	0	0	0	0	1	0	0	0	7885	1783	62	4	259	4	IRS4	23	107976057	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	92366184	107976057	47294503	57	4229										
MBNL3	55796	broad.mit.edu	37	chrX	131573526	131573526	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	tggcaaactcttggtggatgGgcaaacttgcaatctgcatc	11	9	2	0			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chrX:131573526G>T	ENST00000370857.3	-	1	179	c.114C>A	c.(112-114)gcC>gcA	p.A38A	MBNL3_ENST00000370844.1_5'UTR|MBNL3_ENST00000370839.3_Silent_p.A38A|MBNL3_ENST00000370853.3_Silent_p.A38A			Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	38					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					TTGGTGGATGGGCAAACTTGC	0.433													42	172					4.14481e-20	4.42486e-20	1	1	0	T	131573526	G	T	131573526	2	4	45	1	0	0	0	0	0	0	0	1	9404	1219	43	5		5	MBNL3	23	131573526	Silent	SNP	G	TCGA-NA-A5I1-01A-21D-A28R-08	23597469	131573526	23697034	58	4230										
TFDP3	51270	broad.mit.edu	37	chrX	132351648	132351648	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	1	0	ttgttgaagttcagactgttTctgctttattctttcaagtc	7	7	4	2			TCGA-NA-A5I1-01A-21D-A28R-08	TCGA-NA-A5I1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6b5f737c-f956-4cac-8f07-b58b22dca4dc	c63a2da8-53fa-4e7e-bb63-eaf1db77c9cb	g.chrX:132351648T>G	ENST00000310125.4	-	1	728	c.640A>C	c.(640-642)Aaa>Caa	p.K214Q		NM_016521.2	NP_057605.3	Q5H9I0	TFDP3_HUMAN	transcription factor Dp family, member 3	214	DCB1 (By similarity).|Involved in negatively regulating E2F activity.					transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(1)|lung(8)|ovary(1)|prostate(2)	19	Acute lymphoblastic leukemia(192;0.000127)					TCAGACTGTTTCTGCTTTATT	0.458													6	120					0	0	1	0	0	G	132351648	T	G	132351648	3	3	45	1	0	0	0	0	1	0	0	0	15858	1792	62	4	581	4	TFDP3	23	132351648	Missense_Mutation	SNP	T	TCGA-NA-A5I1-01A-21D-A28R-08	778122	132351648	22918912	59	4231										
ARID1A	8289	broad.mit.edu	37	chr1	27106465	27106465	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	acaagcacccagaacggaagCaggcaccactaacttatgaa	8	12	0	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:27106465C>T	ENST00000324856.7	+	20	6447	c.6076C>T	c.(6076-6078)Cag>Tag	p.Q2026*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q1643*|ARID1A_ENST00000540690.1_Nonsense_Mutation_p.Q354*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q1809*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2026					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q2026*(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGAACGGAAGCAGGCACCACT	0.542			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								47	48					0	0	1	0	0	T	27106465	C	T	27106465	4	4	46	1	0	0	0	0	0	1	0	0	910	711	25	3	6154	3	ARID1A	1	27106465	Nonsense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		27106465	222144156	1	4232										
LRRC7	57554	broad.mit.edu	37	chr1	70291497	70291497	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aattattgaagccagtgtcaAtcccatttctaagtgagtat	7	7	2	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:70291497A>T	ENST00000310961.5	+	6	807	c.389A>T	c.(388-390)aAt>aTt	p.N130I	LRRC7_ENST00000035383.5_Missense_Mutation_p.N125I|LRRC7_ENST00000370958.1_Missense_Mutation_p.N163I|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	125						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GCCAGTGTCAATCCCATTTCT	0.269													4	12					0	0	1	0	0	T	70291497	A	T	70291497	3	4	46	1	0	0	0	0	1	0	0	0	9064	101	4	4	384	4	LRRC7	1	70291497	Missense_Mutation	SNP	A	TCGA-ND-A4W6-01A-11D-A28R-08	43185032	70291497	178959124	2	4233										
RAP1A	5906	broad.mit.edu	37	chr1	112234017	112234017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gctagtggtccttggttcagGaggcgttgggaagtctgctc	16	8	2	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:112234017G>A	ENST00000369709.3	+	2	214	c.35G>A	c.(34-36)gGa>gAa	p.G12E	RAP1A_ENST00000436150.2_Missense_Mutation_p.G12E|RAP1A_ENST00000356415.1_Missense_Mutation_p.G12E|RAP1A_ENST00000545460.1_Missense_Mutation_p.G12E|RAP1A_ENST00000494982.1_3'UTR	NM_002884.2	NP_002875.1	P62834	RAP1A_HUMAN	RAP1A, member of RAS oncogene family	12					activation of MAPKK activity|blood coagulation|energy reserve metabolic process|nerve growth factor receptor signaling pathway|regulation of insulin secretion	cytosol|plasma membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(81;6.79e-06)|all_epithelial(167;2.42e-05)|all_lung(203;0.000105)|Lung NSC(277;0.00021)		Lung(183;0.0183)|Colorectal(144;0.0418)|LUSC - Lung squamous cell carcinoma(189;0.0966)|all cancers(265;0.098)|Epithelial(280;0.0981)|COAD - Colon adenocarcinoma(174;0.141)		CTTGGTTCAGGAGGCGTTGGG	0.368													16	13					0	0	1	0	0	A	112234017	G	A	112234017	3	1	46	1	0	0	0	0	1	0	0	0	13086	1174	41	3	37	3	RAP1A	1	112234017	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	41942520	112234017	137016604	3	4234										
HMGCS2	3158	broad.mit.edu	37	chr1	120302610	120302610	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	acagaccaccatggcataacGacctgtaaagagaaacaaga	8	10	0	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:120302610G>A	ENST00000369406.3	-	3	611	c.562C>T	c.(562-564)Cgt>Tgt	p.R188C	HMGCS2_ENST00000544913.2_Intron|HMGCS2_ENST00000476640.1_5'UTR	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	188					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		ATGGCATAACGACCTGTAAAG	0.488													4	24					0	0	1	0	0	A	120302610	G	A	120302610	3	1	46	1	0	0	0	0	1	0	0	0	7273	1058	37	1	992	1	HMGCS2	1	120302610	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	8068593	120302610	128948011	4	4235										
ECM1	1893	broad.mit.edu	37	chr1	150485731	150485731	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	agaaattaaccttcatcaatGatctgtgtggtccccgacgt	8	10	3	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:150485731G>A	ENST00000369047.4	+	10	1536	c.1411G>A	c.(1411-1413)Gat>Aat	p.D471N	ECM1_ENST00000369049.4_Missense_Mutation_p.D498N|ECM1_ENST00000346569.6_Missense_Mutation_p.D346N|ECM1_ENST00000470432.1_3'UTR	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	471					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTTCATCAATGATCTGTGTGG	0.478													13	74					0	0	1	0	0	A	150485731	G	A	150485731	3	1	46	1	0	0	0	0	1	0	0	0	4923	1290	45	3	1449	3	ECM1	1	150485731	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	30183121	150485731	98764890	5	4236										
TCHH	7062	broad.mit.edu	37	chr1	152080396	152080396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	attttctgtcgcgctcctggCggcgcagctgctgttcttcc	11	14	2	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:152080396C>T	ENST00000368804.1	-	2	5296	c.5297G>A	c.(5296-5298)cGc>cAc	p.R1766H		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1766	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGCTCCTGGCGGCGCAGCTG	0.587													19	82					0	0	1	0	0	T	152080396	C	T	152080396	3	4	46	1	0	0	0	0	1	0	0	0	15759	768	27	1	538	1	TCHH	1	152080396	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	1594665	152080396	97170225	6	4237										
B4GALT3	8703	broad.mit.edu	37	chr1	161143778	161143778	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ggcagtcccactcttcatcaCgcagggcctctcgcacccca	8	19	4	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:161143778C>T	ENST00000319769.5	-	5	773	c.551G>A	c.(550-552)cGt>cAt	p.R184H	B4GALT3_ENST00000470882.1_5'UTR|PPOX_ENST00000535223.1_Intron|B4GALT3_ENST00000367998.1_Missense_Mutation_p.R184H|PPOX_ENST00000495483.1_Intron|PPOX_ENST00000432542.2_Intron	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	184					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	CTCTTCATCACGCAGGGCCTC	0.527													40	37					0	0	1	0	0	T	161143778	C	T	161143778	3	4	46	1	0	0	0	0	1	0	0	0	1270	536	19	1	646	1	B4GALT3	1	161143778	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	9063382	161143778	88106843	7	4238										
CACNA1E	777	broad.mit.edu	37	chr1	181702803	181702803	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ctcctgcatcacggccaacaCggacaaggccaccaccgaga	9	17	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:181702803C>T	ENST00000526775.1	+	20	3287	c.3122C>T	c.(3121-3123)aCg>aTg	p.T1041M	CACNA1E_ENST00000367567.4_Missense_Mutation_p.T667M|CACNA1E_ENST00000358338.5_Missense_Mutation_p.T992M|CACNA1E_ENST00000360108.3_Missense_Mutation_p.T1041M|CACNA1E_ENST00000357570.5_Missense_Mutation_p.T1011M|CACNA1E_ENST00000367573.2_Missense_Mutation_p.T1060M|CACNA1E_ENST00000367570.1_Missense_Mutation_p.T1060M	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1060					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACGGCCAACACGGACAAGGCC	0.642													5	15					0	0	1	0	0	T	181702803	C	T	181702803	3	4	46	1	0	0	0	0	1	0	0	0	2560	536	19	1	3261	1	CACNA1E	1	181702803	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	20559025	181702803	67547818	8	4239										
DSTYK	25778	broad.mit.edu	37	chr1	205126443	205126443	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tcacgatggacaagtccctgGctgtgcaggaagcggattcc	13	11	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:205126443G>A	ENST00000367162.3	-	10	2340	c.2310C>T	c.(2308-2310)agC>agT	p.S770S	DSTYK_ENST00000367161.3_Silent_p.S770S|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	770	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						CAAGTCCCTGGCTGTGCAGGA	0.488													22	34					0	0	1	0	0	A	205126443	G	A	205126443	2	1	46	1	0	0	0	0	0	0	0	1	4811	1194	42	3		3	DSTYK	1	205126443	Silent	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	23423640	205126443	44124178	9	4240										
DYRK3	8444	broad.mit.edu	37	chr1	206821770	206821770	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ttaacaggacagcctctcttCcctggagaggatgaaggaga	12	9	1	3	rs146045931		TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:206821770C>T	ENST00000367106.1	+	4	1640	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F	DYRK3_ENST00000367109.2_Silent_p.F409F|DYRK3_ENST00000367108.3_Silent_p.F389F|DYRK3_ENST00000489878.1_Intron			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	409	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			AGCCTCTCTTCCCTGGAGAGG	0.488													46	121					0	0	1	0	0	T	206821770	C	T	206821770	2	4	46	1	0	0	0	0	0	0	0	1	4883	854	30	3		3	DYRK3	1	206821770	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	1695327	206821770	42428851	10	4241										
ITPKB	3707	broad.mit.edu	37	chr1	226923851	226923851	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cactctgtcggagagctgccAacgccccccgcccacggggg	13	18	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:226923851A>T	ENST00000429204.1	-	2	1636	c.1309T>A	c.(1309-1311)Tgg>Agg	p.W437R	ITPKB_ENST00000366784.1_Missense_Mutation_p.W437R|ITPKB_ENST00000272117.3_Missense_Mutation_p.W437R	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	437							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				GAGAGCTGCCAACGCCCCCCG	0.706													5	46					0	0	1	0	0	T	226923851	A	T	226923851	3	4	46	1	0	0	0	0	1	0	0	0	7961	130	5	4	1559	4	ITPKB	1	226923851	Missense_Mutation	SNP	A	TCGA-ND-A4W6-01A-11D-A28R-08	20102081	226923851	22326770	11	4242										
OBSCN	84033	broad.mit.edu	37	chr1	228481947	228481947	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gagctgagcaaggcggcaccGgtggagtggaggaaggggca	21	7	0	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr1:228481947G>A	ENST00000570156.2	+	47	12587	c.12513G>A	c.(12511-12513)ccG>ccA	p.P4171P	OBSCN_ENST00000422127.1_Silent_p.P3742P|OBSCN_ENST00000366709.4_Silent_p.P861P|OBSCN_ENST00000284548.11_Silent_p.P3742P|OBSCN_ENST00000359599.6_Silent_p.P2589P|OBSCN_ENST00000366707.4_Silent_p.P861P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3214	Ig-like 43.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCGGCACCGGTGGAGTGGA	0.627													38	152					0	0	1	0	0	A	228481947	G	A	228481947	2	1	46	1	0	0	0	0	0	0	0	1	10859	1103	39	1		1	OBSCN	1	228481947	Silent	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	1558096	228481947	20768674	12	4243										
APOB	338	broad.mit.edu	37	chr2	21229150	21229150	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ttggaagtgccctgcagcttCactgaagaccgtgtgctctt	11	11	2	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr2:21229150C>A	ENST00000233242.1	-	26	10717	c.10590G>T	c.(10588-10590)gtG>gtT	p.V3530V		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3530					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCTGCAGCTTCACTGAAGACC	0.443													67	68					3.13743e-37	3.52273e-37	1	1	0	A	21229150	C	A	21229150	2	1	46	1	0	0	0	0	0	0	0	1	782	813	29	2		2	APOB	2	21229150	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		21229150	221970223	13	4244										
NRXN1	9378	broad.mit.edu	37	chr2	51254756	51254756	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cgccctcgccctcctcgcccGcctcgcacgggcttcccccg	9	25	0	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr2:51254756G>A	ENST00000404971.1	-	2	1995	c.656C>T	c.(655-657)gCg>gTg	p.A219V	NRXN1_ENST00000406316.2_Missense_Mutation_p.A219V|NRXN1_ENST00000402717.3_Missense_Mutation_p.A219V|NRXN1_ENST00000401669.2_Missense_Mutation_p.A219V|NRXN1_ENST00000406859.3_Missense_Mutation_p.A219V|NRXN1_ENST00000405581.1_Missense_Mutation_p.A219V|NRXN1_ENST00000405472.3_Missense_Mutation_p.A219V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	219	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTCCTCGCCCGCCTCGCACGG	0.716													5	15					0	0	1	0	0	A	51254756	G	A	51254756	3	1	46	1	0	0	0	0	1	0	0	0	10712	1087	38	1	4342	1	NRXN1	2	51254756	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	30025606	51254756	191944617	14	4245										
SLC39A10	57181	broad.mit.edu	37	chr2	196573523	196573523	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ggcatttacttgctatttatCattgaacactgcattagaat	6	7	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr2:196573523C>T	ENST00000409086.3	+	5	1805	c.1530C>T	c.(1528-1530)atC>atT	p.I510I	SLC39A10_ENST00000359634.5_Silent_p.I510I|SLC39A10_ENST00000541054.1_Silent_p.I60I	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	510					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TGCTATTTATCATTGAACACT	0.284													17	41					0	0	1	0	0	T	196573523	C	T	196573523	2	4	46	1	0	0	0	0	0	0	0	1	14667	816	29	3		3	SLC39A10	2	196573523	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	145318767	196573523	46625850	15	4246										
USP19	10869	broad.mit.edu	37	chr3	49154288	49154288	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cgggaggcactgctttctctCctgccaaaggggctaaattc	11	12	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr3:49154288C>G	ENST00000453664.1	-	7	1286	c.968G>C	c.(967-969)gGa>gCa	p.G323A	USP19_ENST00000417901.1_Missense_Mutation_p.G333A|USP19_ENST00000434032.2_Missense_Mutation_p.G333A|USP19_ENST00000398888.2_Missense_Mutation_p.G232A|USP19_ENST00000398896.1_Missense_Mutation_p.G38A|USP19_ENST00000398898.2_Missense_Mutation_p.G270A|USP19_ENST00000398892.3_Missense_Mutation_p.G270A	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	232	CS 2.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGCTTTCTCTCCTGCCAAAGG	0.552													6	42					0	0	1	0	0	G	49154288	C	G	49154288	3	3	46	1	0	0	0	0	1	0	0	0	17109	855	30	2	3345	2	USP19	3	49154288	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		49154288	148868142	16	4247										
BSN	8927	broad.mit.edu	37	chr3	49662661	49662661	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	catcaccctactccgtccctCagatcgccccccttcccagc	4	23	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr3:49662661C>G	ENST00000296452.4	+	2	592	c.478C>G	c.(478-480)Cag>Gag	p.Q160E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	160					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTCCGTCCCTCAGATCGCCCC	0.627													48	39					0	0	1	0	0	G	49662661	C	G	49662661	3	3	46	1	0	0	0	0	1	0	0	0	1532	827	29	2	484	2	BSN	3	49662661	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	508373	49662661	148359769	17	4248										
PIK3CA	5290	broad.mit.edu	37	chr3	178937422	178937422	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aggctatggaacttctggacTgtaattacccagatcctatg	9	9	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr3:178937422T>C	ENST00000263967.3	+	12	1967	c.1810T>C	c.(1810-1812)Tgt>Cgt	p.C604R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	604	PI3K helical.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.C604R(2)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACTTCTGGACTGTAATTACCC	0.368		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			7	16					0	0	1	0	0	C	178937422	T	C	178937422	3	2	46	1	0	0	0	0	1	0	0	0	11960	1580	55	4	1852	4	PIK3CA	3	178937422	Missense_Mutation	SNP	T	TCGA-ND-A4W6-01A-11D-A28R-08	129274761	178937422	19085008	18	4249										
MFN1	55669	broad.mit.edu	37	chr3	179095162	179095162	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	caatgacagatgaaatttgtCgactgtctgttttggttgat	10	5	1	4			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr3:179095162C>T	ENST00000471841.1	+	12	1381	c.1255C>T	c.(1255-1257)Cga>Tga	p.R419*	MFN1_ENST00000280653.7_Nonsense_Mutation_p.R419*|MFN1_ENST00000263969.5_Nonsense_Mutation_p.R419*	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	419					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TGAAATTTGTCGACTGTCTGT	0.234													8	49					0	0	1	0	0	T	179095162	C	T	179095162	4	4	46	1	0	0	0	0	0	1	0	0	9572	876	31	1	1297	1	MFN1	3	179095162	Nonsense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	157740	179095162	18927268	19	4250										
MUC4	4585	broad.mit.edu	37	chr3	195511283	195511283	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	acctgtggatgctgaggaagCgtcggtgacaggaagagggg	19	6	0	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr3:195511283C>T	ENST00000463781.3	-	2	7627	c.7168G>A	c.(7168-7170)Gct>Act	p.A2390T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.A2390T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	148					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.A2390T(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCTGAGGAAGCGTCGGTGACA	0.592													3	10					0	0	1	0	0	T	195511283	C	T	195511283	3	4	46	1	0	0	0	0	1	0	0	0	10025	768	27	1		1	MUC4	3	195511283	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	16416121	195511283	2511147	20	4251										
EPHA5	2044	broad.mit.edu	37	chr4	66361138	66361138	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ttgtgggtggatcagactctCtcctgaaataatccttttca	8	9	3	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr4:66361138C>T	ENST00000273854.3	-	4	1634	c.1034G>A	c.(1033-1035)aGa>aAa	p.R345K	EPHA5_ENST00000511294.1_Missense_Mutation_p.R345K|EPHA5_ENST00000354839.4_Missense_Mutation_p.R345K|EPHA5_ENST00000432638.2_Intron	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	345	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ATCAGACTCTCTCCTGAAATA	0.473										TSP Lung(17;0.13)			30	83					0	0	1	0	0	T	66361138	C	T	66361138	3	4	46	1	0	0	0	0	1	0	0	0	5198	913	32	3	2139	3	EPHA5	4	66361138	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		66361138	124793138	21	4252										
RASGEF1B	153020	broad.mit.edu	37	chr4	82348927	82348927	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ggcagctcccatgtgttaaaCtctgcctaagaggctcgacc	10	13	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr4:82348927C>G	ENST00000509081.1	-	14	1635	c.1414G>C	c.(1414-1416)Gtt>Ctt	p.V472L	RASGEF1B_ENST00000264400.2_Missense_Mutation_p.V473L|RASGEF1B_ENST00000335927.7_Missense_Mutation_p.V431L			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	473					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						ATGTGTTAAACTCTGCCTAAG	0.468													5	21					0	0	1	0	0	G	82348927	C	G	82348927	3	3	46	1	0	0	0	0	1	0	0	0	13121	565	20	5	8	5	RASGEF1B	4	82348927	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	15987789	82348927	108805349	22	4253										
CYP2U1	113612	broad.mit.edu	37	chr4	108866752	108866752	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgtatatgtcgctgaaccccGatgtacaaggtaattaatag	9	7	0	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr4:108866752G>A	ENST00000332884.6	+	2	1392	c.1117G>A	c.(1117-1119)Gat>Aat	p.D373N	RP11-286E11.1_ENST00000513071.1_RNA|CYP2U1_ENST00000508453.1_Missense_Mutation_p.D164N	NM_183075.2	NP_898898.1	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U, polypeptide 1	373					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|large_intestine(2)|lung(4)|skin(2)|urinary_tract(1)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		GCTGAACCCCGATGTACAAGG	0.408													9	61					0	0	1	0	0	A	108866752	G	A	108866752	3	1	46	1	0	0	0	0	1	0	0	0	4198	1058	37	1	1123	1	CYP2U1	4	108866752	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	26517825	108866752	82287524	23	4254										
YTHDC2	64848	broad.mit.edu	37	chr5	112876758	112876758	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gcagagaactgttctaaatgTgactgatgagtatgacttac	10	6	1	5			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr5:112876758T>C	ENST00000161863.4	+	9	1517	c.1304T>C	c.(1303-1305)gTg>gCg	p.V435A	YTHDC2_ENST00000515883.1_Missense_Mutation_p.V435A	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	435							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		GTTCTAAATGTGACTGATGAG	0.403													7	59					0	0	1	0	0	C	112876758	T	C	112876758	3	2	46	1	0	0	0	0	1	0	0	0	17556	1696	59	4	1338	4	YTHDC2	5	112876758	Missense_Mutation	SNP	T	TCGA-ND-A4W6-01A-11D-A28R-08		112876758	68038502	24	4255										
PCDHB5	0	broad.mit.edu	37	chr5	140516678	140516678	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gtgctggtgctggacgccaaCgacaactcgcccttcgtgct	12	14	0	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr5:140516678C>T	ENST00000231134.5	+	1	1879	c.1662C>T	c.(1660-1662)aaC>aaT	p.N554N		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		554	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGACGCCAACGACAACTCGC	0.716													8	147					0	0	1	0	0	T	140516678	C	T	140516678	2	4	46	1	0	0	0	0	0	0	0	1	11591	535	19	1		1	PCDHB5	5	140516678	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	27639920	140516678	40398582	25	4256										
PCDHGA2	0	broad.mit.edu	37	chr5	140719629	140719629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgaagactctcttccaggaaCcataattgggctttttaatg	8	8	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr5:140719629C>T	ENST00000394576.2	+	1	1091	c.1091C>T	c.(1090-1092)aCc>aTc	p.T364I	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCAGGAACCATAATTGGG	0.438													11	78					0	0	1	0	0	T	140719629	C	T	140719629	3	4	46	1	0	0	0	0	1	0	0	0	11600	507	18	3	1093	3	PCDHGA2	5	140719629	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	202951	140719629	40195631	26	4257										
CD74	972	broad.mit.edu	37	chr5	149782827	149782827	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	acttgggcctgaatgaacccGggtggacagcagggatgtgg	17	8	0	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr5:149782827G>A	ENST00000009530.7	-	7	675	c.674C>T	c.(673-675)cCg>cTg	p.P225L	CD74_ENST00000353334.6_Intron|CD74_ENST00000524315.1_Intron|CD74_ENST00000377795.3_Intron			P04233	HG2A_HUMAN	CD74 molecule, major histocompatibility complex, class II invariant chain	225	Thyroglobulin type-1.				antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAATGAACCCGGGTGGACAGC	0.577			T	ROS1	NSCLC								22	180					0	0	1	0	0	A	149782827	G	A	149782827	3	1	46	1	0	0	0	0	1	0	0	0	3057	1116	39	1	228	1	CD74	5	149782827	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	9063198	149782827	31132433	27	4258										
GABRA6	2559	broad.mit.edu	37	chr5	161113261	161113261	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aaaatgccctagggaaactcGaagttgaaggcaacttctac	9	9	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr5:161113261G>T	ENST00000523217.1	+	2	306	c.64G>T	c.(64-66)Gaa>Taa	p.E22*	GABRA6_ENST00000274545.5_Nonsense_Mutation_p.E22*|GABRA6_ENST00000522269.1_3'UTR	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	22					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGGGAAACTCGAAGTTGAAGG	0.478										TCGA Ovarian(5;0.080)			20	42					1.01871e-10	1.10504e-10	1	1	0	T	161113261	G	T	161113261	4	4	46	1	0	0	0	0	0	1	0	0	6199	1059	37	2	70	2	GABRA6	5	161113261	Nonsense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	11330434	161113261	19801999	28	4259										
GRM4	2914	broad.mit.edu	37	chr6	34003773	34003773	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gcagctgcagcgagatgaggCtgaaggtgatggccagctgt	17	8	0	4			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:34003773C>T	ENST00000374181.3	-	8	2283	c.2114G>A	c.(2113-2115)aGc>aAc	p.S705N	GRM4_ENST00000545715.1_Missense_Mutation_p.S397N|GRM4_ENST00000538487.1_Missense_Mutation_p.S705N|GRM4_ENST00000544773.1_Missense_Mutation_p.S536N|GRM4_ENST00000535756.1_Missense_Mutation_p.S572N|GRM4_ENST00000455714.2_Missense_Mutation_p.S565N|GRM4_ENST00000374177.3_Missense_Mutation_p.S589N	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	705					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CGAGATGAGGCTGAAGGTGAT	0.637													21	120					0	0	1	0	0	T	34003773	C	T	34003773	3	4	46	1	0	0	0	0	1	0	0	0	6839	797	28	3	636	3	GRM4	6	34003773	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		34003773	137111294	29	4260										
PTCRA	171558	broad.mit.edu	37	chr6	42890923	42890923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gcaatggcagtgcactggatGccttcacctatggcccttcc	10	14	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:42890923G>A	ENST00000304672.1	+	2	298	c.217G>A	c.(217-219)Gcc>Acc	p.A73T	PTCRA_ENST00000446507.1_Intron|PTCRA_ENST00000441198.1_Missense_Mutation_p.A48T	NM_001243168.1|NM_138296.2	NP_001230097.1|NP_612153.2	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha	73						integral to membrane	receptor activity			large_intestine(2)|lung(4)|ovary(2)	8	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			TGCACTGGATGCCTTCACCTA	0.602													16	134					0	0	1	0	0	A	42890923	G	A	42890923	3	1	46	1	0	0	0	0	1	0	0	0	12783	1319	46	3	223	3	PTCRA	6	42890923	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	8887150	42890923	128224144	30	4261										
DST	667	broad.mit.edu	37	chr6	56484250	56484250	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aaattgttcttttagatgatCtgattttctctggcagattt	7	5	3	4			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:56484250C>T	ENST00000370765.6	-	23	4689	c.4582G>A	c.(4582-4584)Gat>Aat	p.D1528N	DST_ENST00000370754.5_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	5205					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTAGATGATCTGATTTTCTC	0.313													15	26					0	0	1	0	0	T	56484250	C	T	56484250	3	4	46	1	0	0	0	0	1	0	0	0	4809	913	32	3	15821	3	DST	6	56484250	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	13593327	56484250	114630817	31	4262										
MAP3K5	4217	broad.mit.edu	37	chr6	136879965	136879965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tcaagcattttaagtcatcaCgtgtaacatagtagagaaca	7	7	3	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:136879965C>T	ENST00000359015.4	-	29	4397	c.4037G>A	c.(4036-4038)cGt>cAt	p.R1346H	MAP3K5_ENST00000355845.4_Missense_Mutation_p.R593H	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	1346					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TAAGTCATCACGTGTAACATA	0.333													18	42					0	0	1	0	0	T	136879965	C	T	136879965	3	4	46	1	0	0	0	0	1	0	0	0	9302	536	19	1	95	1	MAP3K5	6	136879965	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	80395715	136879965	34235102	32	4263										
PLEKHG1	57480	broad.mit.edu	37	chr6	151130354	151130354	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aagaatgagcggacgctcttCctcttcgacaagctgctgct	10	12	2	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:151130354C>A	ENST00000367328.1	+	9	1338	c.1026C>A	c.(1024-1026)ttC>ttA	p.F342L	PLEKHG1_ENST00000358517.2_Missense_Mutation_p.F342L	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	342	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GGACGCTCTTCCTCTTCGACA	0.562													8	99					1.26484e-09	1.34917e-09	1	1	0	A	151130354	C	A	151130354	3	1	46	1	0	0	0	0	1	0	0	0	12115	854	30	2	1052	2	PLEKHG1	6	151130354	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	14250389	151130354	19984713	33	4264										
SYNE1	23345	broad.mit.edu	37	chr6	152749391	152749391	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ccgtctgtctctccttcgccCtccttaggatgtcctcgtat	7	16	2	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:152749391C>G	ENST00000367255.5	-	37	5526	c.4925G>C	c.(4924-4926)aGg>aCg	p.R1642T	SYNE1_ENST00000367253.4_Missense_Mutation_p.R1642T|SYNE1_ENST00000265368.4_Missense_Mutation_p.R1642T|SYNE1_ENST00000423061.1_Missense_Mutation_p.R1649T|SYNE1_ENST00000341594.5_Missense_Mutation_p.R1712T|SYNE1_ENST00000448038.1_Missense_Mutation_p.R1649T	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1642					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCTTCGCCCTCCTTAGGAT	0.532										HNSCC(10;0.0054)			40	196					0	0	1	0	0	G	152749391	C	G	152749391	3	3	46	1	0	0	0	0	1	0	0	0	15501	681	24	5	21981	5	SYNE1	6	152749391	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	1619037	152749391	18365676	34	4265										
SYNE1	23345	broad.mit.edu	37	chr6	152831401	152831401	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gatcttggtggtcaccttccGtttacttggtgggctgggag	15	8	2	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:152831401G>A	ENST00000367255.5	-	8	1109	c.508C>T	c.(508-510)Cgg>Tgg	p.R170W	SYNE1_ENST00000367253.4_Missense_Mutation_p.R170W|SYNE1_ENST00000265368.4_Missense_Mutation_p.R170W|SYNE1_ENST00000423061.1_Missense_Mutation_p.R177W|SYNE1_ENST00000341594.5_Missense_Mutation_p.R170W|SYNE1_ENST00000413186.2_Missense_Mutation_p.R170W|SYNE1_ENST00000466159.2_Missense_Mutation_p.R170W|SYNE1_ENST00000448038.1_Missense_Mutation_p.R177W|SYNE1_ENST00000367248.3_Missense_Mutation_p.R177W	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	170	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.R170W(7)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTCACCTTCCGTTTACTTGGT	0.483										HNSCC(10;0.0054)			37	48					0	0	1	0	0	A	152831401	G	A	152831401	3	1	46	1	0	0	0	0	1	0	0	0	15501	1144	40	1	26514	1	SYNE1	6	152831401	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	82010	152831401	18283666	35	4266										
C6orf70	0	broad.mit.edu	37	chr6	170181480	170181480	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ctggtggcttacaccagttaCgaaaagaacaagtggaatga	11	7	0	2	rs151319719	byFrequency	TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr6:170181480C>T	ENST00000588451.1	+	17	2013	c.1500C>T	c.(1498-1500)taC>taT	p.Y500Y	C6orf70_ENST00000366772.2_Silent_p.Y589Y|C6orf70_ENST00000418781.3_Silent_p.Y563Y|C6orf70_ENST00000366773.3_Silent_p.Y636Y|C6orf70_ENST00000392095.4_Silent_p.Y510Y			Q5T6L9	CF070_HUMAN		636						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		ACACCAGTTACGAAAAGAACA	0.323													8	19					0	0	1	0	0	T	170181480	C	T	170181480	2	4	46	1	0	0	0	0	0	0	0	1	2385	547	19	1		1	C6orf70	6	170181480	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	17350079	170181480	933587	36	4267										
FERD3L	222894	broad.mit.edu	37	chr7	19184880	19184880	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgggtcccccaaggagacccCgggtgcgaagtcgcagagga	16	12	0	2	rs145435922		TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr7:19184880C>T	ENST00000275461.3	-	1	164	c.106G>A	c.(106-108)Ggg>Agg	p.G36R	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	36			G -> R (in a colorectal cancer sample; somatic mutation).		negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.G36R(1)		breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						AAGGAGACCCCGGGTGCGAAG	0.657													4	43					0	0	1	0	0	T	19184880	C	T	19184880	3	4	46	1	0	0	0	0	1	0	0	0	5848	652	23	1	398	1	FERD3L	7	19184880	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		19184880	139953783	37	4268										
CREB5	9586	broad.mit.edu	37	chr7	28547289	28547289	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgcgaggaggtgggcctcttCagcgagctggactgctccct	15	12	2	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr7:28547289C>T	ENST00000357727.2	+	4	615	c.225C>T	c.(223-225)ttC>ttT	p.F75F	CREB5_ENST00000396299.2_Silent_p.F42F|CREB5_ENST00000396300.2_Silent_p.F68F|CREB5_ENST00000409603.1_Silent_p.F42F	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	75					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						TGGGCCTCTTCAGCGAGCTGG	0.542													78	104					0	0	1	0	0	T	28547289	C	T	28547289	2	4	46	1	0	0	0	0	0	0	0	1	3883	825	29	3		3	CREB5	7	28547289	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	9362409	28547289	130591374	38	4269										
HGF	3082	broad.mit.edu	37	chr7	81388026	81388026	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	acctttgttttcatagaggtCaaattcatggccaaattctt	6	8	4	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr7:81388026C>G	ENST00000222390.5	-	3	575	c.349G>C	c.(349-351)Gac>Cac	p.D117H	HGF_ENST00000444829.2_Missense_Mutation_p.D117H|HGF_ENST00000457544.2_Missense_Mutation_p.D117H|HGF_ENST00000354224.6_Missense_Mutation_p.D117H|HGF_ENST00000453411.1_Missense_Mutation_p.D117H|HGF_ENST00000423064.2_Missense_Mutation_p.D117H|HGF_ENST00000453018.1_Missense_Mutation_p.D14H	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	117	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TCATAGAGGTCAAATTCATGG	0.348													16	13					0	0	1	0	0	G	81388026	C	G	81388026	3	3	46	1	0	0	0	0	1	0	0	0	7125	826	29	2	1921	2	HGF	7	81388026	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	52840737	81388026	77750637	39	4270										
PCLO	27445	broad.mit.edu	37	chr7	82584377	82584377	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ccatctaccgatccattgtaCgtgtcttctactaaagattc	5	12	3	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr7:82584377C>T	ENST00000423517.2	-	5	6229	c.5892G>A	c.(5890-5892)acG>acA	p.T1964T	PCLO_ENST00000333891.8_Silent_p.T1964T	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1895					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATCCATTGTACGTGTCTTCTA	0.383													9	48					0	0	1	0	0	T	82584377	C	T	82584377	2	4	46	1	0	0	0	0	0	0	0	1	11629	523	19	1		1	PCLO	7	82584377	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	1196351	82584377	76554286	40	4271										
PCLO	27445	broad.mit.edu	37	chr7	82584412	82584412	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	agattcataaatataatcctCtattagcatcccaccataca	2	11	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr7:82584412C>G	ENST00000423517.2	-	5	6194	c.5857G>C	c.(5857-5859)Gag>Cag	p.E1953Q	PCLO_ENST00000333891.8_Missense_Mutation_p.E1953Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1884					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATATAATCCTCTATTAGCATC	0.368													5	47					0	0	1	0	0	G	82584412	C	G	82584412	3	3	46	1	0	0	0	0	1	0	0	0	11629	922	32	2	9672	2	PCLO	7	82584412	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	35	82584412	76554251	41	4272										
LMTK2	22853	broad.mit.edu	37	chr7	97736519	97736521	+	In_Frame_Del	DEL	GCT	GCT	-													0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ccgccggcgttgcggcggagGctgctgctgctgctgctggt							TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr7:97736519_97736521delGCT	ENST00000297293.5	+	1	323_325	c.30_32delGCT	c.(28-33)agg>ag	p.RL10del		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	10					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TGCGGCGGAGGCTGCTGCTGCTG	0.764													3	3	---	---	---	---						-	97736521	GCT	-	97736519	7	5	46	1	0	1	0	1	0	0	0	0	8899	1194	42	0	32	0	LMTK2	7	97736519	In_Frame_Del	DEL	GCT	TCGA-ND-A4W6-01A-11D-A28R-08	15152107	97736519	61402144	42	4273										
CHRNA2	0	broad.mit.edu	37	chr8	27321250	27321250	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tcttgctgttgtaggtgcccGtggcattgacgatggcccac	13	11	1	1	rs140350483	byFrequency	TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr8:27321250G>A	ENST00000407991.1	-	6	1318	c.710C>T	c.(709-711)aCg>aTg	p.T237M	CHRNA2_ENST00000240132.2_Missense_Mutation_p.T222M|CHRNA2_ENST00000520933.2_Missense_Mutation_p.T237M	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	237						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GTAGGTGCCCGTGGCATTGAC	0.592													29	35					0	0	1	0	0	A	27321250	G	A	27321250	3	1	46	1	0	0	0	0	1	0	0	0	3405	1145	40	1	887	1	CHRNA2	8	27321250	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		27321250	119042772	43	4274										
XKR4	114786	broad.mit.edu	37	chr8	56435862	56435862	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ttcacagcggcagcttccctCgtgtccctggcctgggcctt	11	16	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr8:56435862C>T	ENST00000327381.5	+	3	1129	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	343						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCTTCCCTCGTGTCCCTGG	0.572													35	10					0	0	1	0	0	T	56435862	C	T	56435862	2	4	46	1	0	0	0	0	0	0	0	1	17492	871	31	1		1	XKR4	8	56435862	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	29114612	56435862	89928160	44	4275										
PABPC1	26986	broad.mit.edu	37	chr8	101727709	101727709	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ccaaacttgccaaagagatcCttaaggcgctcatcatccat	6	13	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr8:101727709C>A	ENST00000318607.5	-	4	1752	c.624G>T	c.(622-624)aaG>aaT	p.K208N	PABPC1_ENST00000519596.1_5'UTR|PABPC1_ENST00000522387.1_Missense_Mutation_p.K176N|PABPC1_ENST00000519004.1_Missense_Mutation_p.K163N	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	208	CSDE1-binding.|RRM 3.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CAAAGAGATCCTTAAGGCGCT	0.353													8	89					1.26484e-09	1.34917e-09	1	1	0	A	101727709	C	A	101727709	3	1	46	1	0	0	0	0	1	0	0	0	11409	680	24	5	1330	5	PABPC1	8	101727709	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	45291847	101727709	44636313	45	4276										
LRRC24	441381	broad.mit.edu	37	chr8	145749618	145749618	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cccgctagagcctggtcctcCagcagctcaatgctgttttc	9	15	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr8:145749618C>G	ENST00000529415.2	-	4	600	c.483G>C	c.(481-483)ctG>ctC	p.L161L	LRRC14_ENST00000528528.1_Intron|LRRC24_ENST00000533758.1_Silent_p.L158L|LRRC14_ENST00000292524.1_3'UTR			Q50LG9	LRC24_HUMAN	leucine rich repeat containing 24	161						integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCTGGTCCTCCAGCAGCTCAA	0.617													11	173					0	0	1	0	0	G	145749618	C	G	145749618	2	3	46	1	0	0	0	0	0	0	0	1	9023	581	21	5		5	LRRC24	8	145749618	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	44021909	145749618	614404	46	4277										
FRMPD1	22844	broad.mit.edu	37	chr9	37745756	37745756	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ggcaagatatagcccctaggGacagccctgagtgggtctgt	14	10	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr9:37745756G>T	ENST00000539465.1	+	16	4320	c.3727G>T	c.(3727-3729)Gac>Tac	p.D1243Y	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.D1243Y			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1243						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AGCCCCTAGGGACAGCCCTGA	0.512													44	60					3.66854e-30	4.08325e-30	1	1	0	T	37745756	G	T	37745756	3	4	46	1	0	0	0	0	1	0	0	0	6091	1174	41	2	3785	2	FRMPD1	9	37745756	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		37745756	103467675	47	4278										
KLF6	1316	broad.mit.edu	37	chr10	3822356	3822356	+	Frame_Shift_Del	DEL	T	T	-													0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gtgctttcggaagtgcctggTtaactcatcacttcttgcaa							TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr10:3822356delT	ENST00000497571.1	-	3	1002	c.742delA	c.(742-744)ccfs	p.T248fs	KLF6_ENST00000173785.4_5'UTR|KLF6_ENST00000542957.1_Intron	NM_001160124.1|NM_001300.5	NP_001153596.1|NP_001291.3	Q99612	KLF6_HUMAN	Kruppel-like factor 6	248					B cell differentiation	nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				Colorectal(1;0.238)		AAGTGCCTGGTTAACTCATCA	0.552													40	44	---	---	---	---						-	3822356	T	-	3822356	7	5	46	1	0	1	0	1	0	0	0	0	8392	1725	60	0	117	0	KLF6	10	3822356	Frame_Shift_Del	DEL	T	TCGA-ND-A4W6-01A-11D-A28R-08		3822356	131712391	48	4279										
CTNNA3	29119	broad.mit.edu	37	chr10	67862963	67862963	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ctggtgtgactgcggacctcGtgttcctcttcaaggtcaga	12	11	3	2	rs147760277	byFrequency	TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr10:67862963G>A	ENST00000433211.1	-	14	2103	c.1929C>T	c.(1927-1929)caC>caT	p.H643H	CTNNA3_ENST00000373744.4_Silent_p.H643H	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	643					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TGCGGACCTCGTGTTCCTCTT	0.458													25	16					0	0	1	0	0	A	67862963	G	A	67862963	2	1	46	1	0	0	0	0	0	0	0	1	4038	1136	40	1		1	CTNNA3	10	67862963	Silent	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	64040607	67862963	67671784	49	4280										
CTBP2	1488	broad.mit.edu	37	chr10	126716241	126716241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ccccagaggccgcagggactCggcgttctcccaggggccct	14	17	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr10:126716241C>T	ENST00000309035.6	-	1	218	c.88G>A	c.(88-90)Gag>Aag	p.E30K	CTBP2_ENST00000337195.5_Intron|CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000494626.2_Intron|CTBP2_ENST00000411419.2_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding	p.E30K(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CGCAGGGACTCGGCGTTCTCC	0.587													4	26					0	0	1	0	0	T	126716241	C	T	126716241	3	4	46	1	0	0	0	0	1	0	0	0	4022	893	31	1	2905	1	CTBP2	10	126716241	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	58853278	126716241	8818506	50	4281										
OR52W1	120787	broad.mit.edu	37	chr11	6221330	6221330	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	acttgctgctgccacctgccCtcaaccccctcatctatggg	7	18	3	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:6221330C>A	ENST00000311352.2	+	1	955	c.877C>A	c.(877-879)Ctc>Atc	p.L293I		NM_001005178.1	NP_001005178.1	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)	11		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCACCTGCCCTCAACCCCCT	0.532													5	297					0.217242	0.218953	1	1	0	A	6221330	C	A	6221330	3	1	46	1	0	0	0	0	1	0	0	0	11179	681	24	5	879	5	OR52W1	11	6221330	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		6221330	128785186	51	4282										
OR5L1	219437	broad.mit.edu	37	chr11	55579557	55579557	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ctgttcctggtggccactttGaatgagagtgttaccatcat	10	9	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:55579557G>A	ENST00000333973.2	+	1	704	c.615G>A	c.(613-615)ttG>ttA	p.L205L		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGGCCACTTTGAATGAGAGTG	0.468													16	104					0	0	1	0	0	A	55579557	G	A	55579557	2	1	46	1	0	0	0	0	0	0	0	1	11216	1281	45	3		3	OR5L1	11	55579557	Silent	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	49358227	55579557	79426959	52	4283										
NRXN2	9379	broad.mit.edu	37	chr11	64374750	64374750	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gggccttctctttcaccaccGccccattgctctgggccgag	10	17	3	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:64374750G>A	ENST00000265459.6	-	23	5518	c.5057C>T	c.(5056-5058)gCg>gTg	p.A1686V	NRXN2_ENST00000377559.3_Missense_Mutation_p.A1616V|NRXN2_ENST00000301894.2_Missense_Mutation_p.A640V|NRXN2_ENST00000409571.1_Missense_Mutation_p.A1679V|NRXN2_ENST00000377551.1_Missense_Mutation_p.A1686V	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1686					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TTTCACCACCGCCCCATTGCT	0.582													9	29					0	0	1	0	0	A	64374750	G	A	64374750	3	1	46	1	0	0	0	0	1	0	0	0	10713	1087	38	1	85	1	NRXN2	11	64374750	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	8795193	64374750	70631766	53	4284										
GAL3ST3	89792	broad.mit.edu	37	chr11	65810819	65810819	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cgaacatggcggccggctcgCgcaggatggtgacatagacg	16	11	0	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:65810819C>T	ENST00000312006.4	-	3	736	c.455G>A	c.(454-456)cGc>cAc	p.R152H	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.R152H	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	152					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GGCCGGCTCGCGCAGGATGGT	0.697													7	22					0	0	1	0	0	T	65810819	C	T	65810819	3	4	46	1	0	0	0	0	1	0	0	0	6238	768	27	1	844	1	GAL3ST3	11	65810819	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	1436069	65810819	69195697	54	4285										
LRP5	4041	broad.mit.edu	37	chr11	68170953	68170953	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	atttctgccgtcctgcaggtGatcaatgttgatgggacgaa	12	8	2	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:68170953G>A	ENST00000294304.7	+	8	1693	c.1587G>A	c.(1585-1587)gtG>gtA	p.V529V		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	529	Beta-propeller 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TCCTGCAGGTGATCAATGTTG	0.592													10	40					0	0	1	0	0	A	68170953	G	A	68170953	2	1	46	1	0	0	0	0	0	0	0	1	9004	1277	45	3		3	LRP5	11	68170953	Silent	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	2360134	68170953	66835563	55	4286										
FAT3	120114	broad.mit.edu	37	chr11	92523240	92523240	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gaagccacagatagagatgaGaagcacaagctgagctacac	11	9	0	4			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:92523240G>C	ENST00000298047.6	+	7	4484	c.4467G>C	c.(4465-4467)gaG>gaC	p.E1489D	FAT3_ENST00000525166.1_Missense_Mutation_p.E1339D|FAT3_ENST00000409404.2_Missense_Mutation_p.E1489D			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1489	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATAGAGATGAGAAGCACAAGC	0.493										TCGA Ovarian(4;0.039)			42	114					0	0	1	0	0	C	92523240	G	C	92523240	3	2	46	1	0	0	0	0	1	0	0	0	5723	933	33	2	4493	2	FAT3	11	92523240	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	24352287	92523240	42483276	56	4287										
PUS3	83480	broad.mit.edu	37	chr11	125765618	125765618	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	agcagcagcattagcctcctCttttacattaaagtcctcgg	7	12	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr11:125765618C>G	ENST00000227474.3	-	3	542	c.445G>C	c.(445-447)Gag>Cag	p.E149Q	PUS3_ENST00000530811.1_Missense_Mutation_p.E149Q|HYLS1_ENST00000425380.2_Intron|HYLS1_ENST00000356438.3_Intron|HYLS1_ENST00000526028.1_Intron	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597.3	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	149						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		TTAGCCTCCTCTTTTACATTA	0.493													26	69					0	0	1	0	0	G	125765618	C	G	125765618	3	3	46	1	0	0	0	0	1	0	0	0	12883	922	32	2	1008	2	PUS3	11	125765618	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	33242378	125765618	9240898	57	4288										
FGF6	2251	broad.mit.edu	37	chr12	4554486	4554486	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgcagtagagcctccgctgcCgcttgatccccaccaaatag	9	15	0	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr12:4554486C>T	ENST00000228837.2	-	1	294	c.251G>A	c.(250-252)cGg>cAg	p.R84Q		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	84					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			CCTCCGCTGCCGCTTGATCCC	0.652													35	79					0	0	1	0	0	T	4554486	C	T	4554486	3	4	46	1	0	0	0	0	1	0	0	0	5888	652	23	1	387	1	FGF6	12	4554486	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		4554486	129297409	58	4289										
LRP1	4035	broad.mit.edu	37	chr12	57581077	57581077	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ctccgtggaaggcctggcctAtcaccgtggctgggacactc	13	14	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr12:57581077A>G	ENST00000243077.3	+	42	7335	c.6869A>G	c.(6868-6870)tAt>tGt	p.Y2290C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2290					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCTGGCCTATCACCGTGGC	0.637													26	42					0	0	1	0	0	G	57581077	A	G	57581077	3	3	46	1	0	0	0	0	1	0	0	0	8995	449	16	4	7035	4	LRP1	12	57581077	Missense_Mutation	SNP	A	TCGA-ND-A4W6-01A-11D-A28R-08	53026591	57581077	76270818	59	4290										
OS9	10956	broad.mit.edu	37	chr12	58113962	58113962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	atcaggatctgactgtcctcGagatgaaacgggaaaaccca	10	10	2	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr12:58113962G>A	ENST00000315970.7	+	13	1722	c.1681G>A	c.(1681-1683)Gag>Aag	p.E561K	OS9_ENST00000413095.2_Intron|OS9_ENST00000257966.8_Intron|OS9_ENST00000551035.1_Intron|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000389142.5_Intron|OS9_ENST00000552285.1_Intron|OS9_ENST00000439210.2_Intron|OS9_ENST00000435406.2_Intron|OS9_ENST00000389146.6_Missense_Mutation_p.E546K	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	561					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GACTGTCCTCGAGATGAAACG	0.602													39	85					0	0	1	0	0	A	58113962	G	A	58113962	3	1	46	1	0	0	0	0	1	0	0	0	11318	1059	37	1	1731	1	OS9	12	58113962	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	532885	58113962	75737933	60	4291										
TPH2	121278	broad.mit.edu	37	chr12	72338371	72338371	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cactgttttcaacagagctaGaggatgtgccctggttccct	10	11	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr12:72338371G>C	ENST00000333850.3	+	4	586	c.445G>C	c.(445-447)Gag>Cag	p.E149Q	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	149					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	AACAGAGCTAGAGGATGTGCC	0.433													20	76					0	0	1	0	0	C	72338371	G	C	72338371	3	2	46	1	0	0	0	0	1	0	0	0	16462	943	33	2	459	2	TPH2	12	72338371	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	14224409	72338371	61513524	61	4292										
USPL1	10208	broad.mit.edu	37	chr13	31233271	31233271	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gatgtttcccagaacacacaTctgagacaggaccataatta	7	10	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr13:31233271T>C	ENST00000255304.4	+	9	3399	c.3057T>C	c.(3055-3057)caT>caC	p.H1019H		NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	1019					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AGAACACACATCTGAGACAGG	0.418													14	80					0	0	1	0	0	C	31233271	T	C	31233271	2	2	46	1	0	0	0	0	0	0	0	1	17151	1432	50	4		4	USPL1	13	31233271	Silent	SNP	T	TCGA-ND-A4W6-01A-11D-A28R-08		31233271	83936607	62	4293										
PARP2	10038	broad.mit.edu	37	chr14	20818779	20818779	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgtttggatgagatggggccGaggtaatgatttttattgag	15	2	0	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr14:20818779G>A	ENST00000527915.1	+	5	463	c.458G>A	c.(457-459)cGa>cAa	p.R153Q	PARP2_ENST00000250416.5_Missense_Mutation_p.R153Q|PARP2_ENST00000429687.3_Missense_Mutation_p.R140Q			Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase 2	153					protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	15	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		AGATGGGGCCGAGGTAATGAT	0.413								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					8	52					0	0	1	0	0	A	20818779	G	A	20818779	3	1	46	1	0	0	0	0	1	0	0	0	11507	1058	37	1	476	1	PARP2	14	20818779	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		20818779	86530761	63	4294										
JPH4	84502	broad.mit.edu	37	chr14	24040296	24040296	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gggggcaggggctcttcatcCtccccctcctcctctcgaag	11	17	3	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr14:24040296C>T	ENST00000397118.3	-	6	2546	c.1644G>A	c.(1642-1644)gaG>gaA	p.E548E	JPH4_ENST00000356300.4_Silent_p.E548E|JPH4_ENST00000544177.1_Silent_p.E213E	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	548					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GCTCTTCATCCTCCCCCTCCT	0.672													65	61					0	0	1	0	0	T	24040296	C	T	24040296	2	4	46	1	0	0	0	0	0	0	0	1	8006	680	24	3		3	JPH4	14	24040296	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	3221517	24040296	83309244	64	4295										
AKAP6	9472	broad.mit.edu	37	chr14	33292748	33292748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	agaaaggcaaaagggaaaacCgaatgtgacttcaaaggtat	11	5	1	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr14:33292748C>T	ENST00000280979.4	+	13	5899	c.5729C>T	c.(5728-5730)cCg>cTg	p.P1910L	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1910					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAGGGAAAACCGAATGTGACT	0.343													7	26					0	0	1	0	0	T	33292748	C	T	33292748	3	4	46	1	0	0	0	0	1	0	0	0	452	652	23	1	5775	1	AKAP6	14	33292748	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	9252452	33292748	74056792	65	4296										
C14orf79	122616	broad.mit.edu	37	chr14	105455303	105455303	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	attctcagctatgagaacatTttaaagtgtgcttttcaaga	7	6	2	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr14:105455303T>G	ENST00000547315.1	+	2	1086	c.447T>G	c.(445-447)atT>atG	p.I149M	C14orf79_ENST00000550614.1_5'UTR|C14orf79_ENST00000549584.1_3'UTR	NM_174891.3	NP_777551.2	Q96F83	CN079_HUMAN	chromosome 14 open reading frame 79	149										breast(1)|endometrium(1)|lung(1)	3		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00326)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0181)			ATGAGAACATTTTAAAGTGTG	0.373													6	32					0	0	1	0	0	G	105455303	T	G	105455303	3	3	46	1	0	0	0	0	1	0	0	0	1786	1829	64	4	453	4	C14orf79	14	105455303	Missense_Mutation	SNP	T	TCGA-ND-A4W6-01A-11D-A28R-08	72162555	105455303	1894237	66	4297										
PLA2G4D	283748	broad.mit.edu	37	chr15	42374009	42374009	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ccttaccagccctctgccttGagctgcagcctcactcctgg	8	18	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr15:42374009G>C	ENST00000290472.3	-	10	901	c.807C>G	c.(805-807)ctC>ctG	p.L269L		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	269					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CCTCTGCCTTGAGCTGCAGCC	0.587													57	83					0	0	1	0	0	C	42374009	G	C	42374009	2	2	46	1	0	0	0	0	0	0	0	1	12051	1277	45	2		2	PLA2G4D	15	42374009	Silent	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		42374009	60157383	67	4298										
PRTG	283659	broad.mit.edu	37	chr15	55931950	55931950	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ggcctcctccagtgcaggaaGatggaagatgaggtgttagc	15	8	0	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr15:55931950G>C	ENST00000389286.4	-	13	2261	c.2214C>G	c.(2212-2214)atC>atG	p.I738M		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	738	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGTGCAGGAAGATGGAAGATG	0.488													43	42					0	0	1	0	0	C	55931950	G	C	55931950	3	2	46	1	0	0	0	0	1	0	0	0	12686	932	33	2	1270	2	PRTG	15	55931950	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	13557941	55931950	46599442	68	4299										
ALG1	56052	broad.mit.edu	37	chr16	5122951	5122951	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gggatcattctcatttttcaGactccaaaccccatgatgag	7	11	3	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr16:5122951G>T	ENST00000588623.1	+	3	975		c.e3-1		ALG1_ENST00000544428.1_Splice_Site|ALG1_ENST00000262374.5_Splice_Site			Q9BT22	ALG1_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase						dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(90;0.0164)				TCATTTTTCAGACTCCAAACC	0.438													6	75					0.00198382	0.00206446	1	1	0	T	5122951	G	T	5122951	5	4	46	1	0	0	0	0	0	0	1	0	507	956	33	2	214	2	ALG1	16	5122951	Splice_Site	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		5122951	85231802	69	4300										
CDH16	1014	broad.mit.edu	37	chr16	66944333	66944333	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gggagggcacaggggcaagaGtcagggctggggcaggaggg	24	6	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr16:66944333G>C	ENST00000299752.4	-	15	2190	c.1997C>G	c.(1996-1998)aCt>aGt	p.T666S	CDH16_ENST00000565796.1_Intron|CDH16_ENST00000394055.3_Missense_Mutation_p.T644S|CDH16_ENST00000570262.1_Missense_Mutation_p.T586S|CDH16_ENST00000568632.1_Missense_Mutation_p.T569S	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	666	Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		AGGGGCAAGAGTCAGGGCTGG	0.637													50	35					0	0	1	0	0	C	66944333	G	C	66944333	3	2	46	1	0	0	0	0	1	0	0	0	3123	1029	36	5	508	5	CDH16	16	66944333	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	61821382	66944333	23410420	70	4301										
AP1G1	164	broad.mit.edu	37	chr16	71823359	71823359	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cggatggtccggatcagctcCcgcaatctgatgggggctgg	16	11	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr16:71823359C>A	ENST00000299980.4	-	2	465	c.24G>T	c.(22-24)cgG>cgT	p.R8R	AP1G1_ENST00000569748.1_Silent_p.R8R|AP1G1_ENST00000433195.2_Silent_p.R31R|AP1G1_ENST00000423132.2_Silent_p.R8R|AP1G1_ENST00000393512.3_Silent_p.R8R|AP1G1_ENST00000570297.1_5'UTR	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	8					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				GGATCAGCTCCCGCAATCTGA	0.453													12	26					6.53275e-17	7.20855e-17	1	1	0	A	71823359	C	A	71823359	2	1	46	1	0	0	0	0	0	0	0	1	728	610	22	5		5	AP1G1	16	71823359	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	4879026	71823359	18531394	71	4302										
TP53	7157	broad.mit.edu	37	chr17	7577559	7577559	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ggttcatgccgcccatgcagGaactgttacacatgtagttg	11	10	1	0	rs28934573		TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:7577559G>T	ENST00000420246.2	-	7	854	c.722C>A	c.(721-723)tCc>tAc	p.S241Y	TP53_ENST00000455263.2_Missense_Mutation_p.S241Y|TP53_ENST00000445888.2_Missense_Mutation_p.S241Y|TP53_ENST00000359597.4_Missense_Mutation_p.S241Y|TP53_ENST00000269305.4_Missense_Mutation_p.S241Y|TP53_ENST00000413465.2_Missense_Mutation_p.S241Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	24					4.22769e-11	4.62517e-11	1	1	0	T	7577559	G	T	7577559	3	4	46	1	0	0	0	0	1	0	0	0	16441	1174	41	2	568	2	TP53	17	7577559	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		7577559	73617651	72	4303										
MYH2	4620	broad.mit.edu	37	chr17	10432392	10432392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cctcctccagctcctcaatgCgggcctgggaatggtggaaa	12	13	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:10432392C>T	ENST00000245503.5	-	27	3743	c.3359G>A	c.(3358-3360)cGc>cAc	p.R1120H	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.R1120H|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1120					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTCCTCAATGCGGGCCTGGGA	0.532													35	19					0	0	1	0	0	T	10432392	C	T	10432392	3	4	46	1	0	0	0	0	1	0	0	0	10082	768	27	1	2522	1	MYH2	17	10432392	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	2854833	10432392	70762818	73	4304										
TMUB2	79089	broad.mit.edu	37	chr17	42268225	42268225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cctagtatttgggatgtatgGacgataaggacataggaaga	13	4	0	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:42268225G>A	ENST00000319511.6	+	3	1549	c.899G>A	c.(898-900)gGa>gAa	p.G300E	TMUB2_ENST00000587989.1_Missense_Mutation_p.G320E|TMUB2_ENST00000538716.2_Missense_Mutation_p.G320E|TMUB2_ENST00000446571.3_Missense_Mutation_p.G263E|TMUB2_ENST00000357984.3_Missense_Mutation_p.G300E|TMUB2_ENST00000590235.1_3'UTR|TMUB2_ENST00000589785.1_Missense_Mutation_p.G300E|TMUB2_ENST00000592825.1_3'UTR|TMUB2_ENST00000587172.1_3'UTR|TMUB2_ENST00000589184.1_3'UTR	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	320						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GGGATGTATGGACGATAAGGA	0.527													44	112					0	0	1	0	0	A	42268225	G	A	42268225	3	1	46	1	0	0	0	0	1	0	0	0	16324	1174	41	3	969	3	TMUB2	17	42268225	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	31835833	42268225	38926985	74	4305										
SLC16A5	9121	broad.mit.edu	37	chr17	73096220	73096220	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gtctccctgggcatcaccctCtggccgctgctctcccgcta	9	19	4	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:73096220C>T	ENST00000450736.2	+	4	877	c.462C>T	c.(460-462)ctC>ctT	p.L154L	SLC16A5_ENST00000538213.2_Silent_p.L194L|SLC16A5_ENST00000580123.1_Silent_p.L154L|SLC16A5_ENST00000329783.4_Silent_p.L154L			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	154					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GCATCACCCTCTGGCCGCTGC	0.647													13	45					0	0	1	0	0	T	73096220	C	T	73096220	2	4	46	1	0	0	0	0	0	0	0	1	14465	900	32	3		3	SLC16A5	17	73096220	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	30827995	73096220	8098990	75	4306			1	8		5	5	4009	C		9.428719e-10
SLC16A5	9121	broad.mit.edu	37	chr17	73096514	73096514	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	atgtggtccgtcctgggcttCccactgccacaagtcttcct	9	15	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:73096514C>T	ENST00000450736.2	+	4	1171	c.756C>T	c.(754-756)ttC>ttT	p.F252F	SLC16A5_ENST00000538213.2_Silent_p.F292F|SLC16A5_ENST00000580123.1_Silent_p.F252F|SLC16A5_ENST00000329783.4_Silent_p.F252F			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	252					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity	p.F252L(2)		central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TCCTGGGCTTCCCACTGCCAC	0.607													17	52					0	0	1	0	0	T	73096514	C	T	73096514	2	4	46	1	0	0	0	0	0	0	0	1	14465	854	30	3		3	SLC16A5	17	73096514	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	294	73096514	8098696	76	4307			1	8		5	5	4009	C		9.428719e-10
SLC16A5	9121	broad.mit.edu	37	chr17	73096694	73096694	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tacctgttcagcctggcactCctgctcaatgggctcactaa	8	14	3	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:73096694C>G	ENST00000450736.2	+	4	1351	c.936C>G	c.(934-936)ctC>ctG	p.L312L	SLC16A5_ENST00000538213.2_Silent_p.L352L|SLC16A5_ENST00000580123.1_Silent_p.L312L|SLC16A5_ENST00000329783.4_Silent_p.L312L			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	312					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GCCTGGCACTCCTGCTCAATG	0.612													26	113					0	0	1	0	0	G	73096694	C	G	73096694	2	3	46	1	0	0	0	0	0	0	0	1	14465	842	30	2		2	SLC16A5	17	73096694	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	180	73096694	8098516	77	4308			1	8		5	5	4009	C		9.428719e-10
SLC16A5	9121	broad.mit.edu	37	chr17	73096839	73096839	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tggacatcgtccccatggatCagttccccagagccctggga	11	14	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:73096839C>T	ENST00000450736.2	+	4	1496	c.1081C>T	c.(1081-1083)Cag>Tag	p.Q361*	SLC16A5_ENST00000538213.2_Nonsense_Mutation_p.Q401*|SLC16A5_ENST00000580123.1_Nonsense_Mutation_p.Q361*|SLC16A5_ENST00000329783.4_Nonsense_Mutation_p.Q361*			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	361					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	CCCCATGGATCAGTTCCCCAG	0.627													15	49					0	0	1	0	0	T	73096839	C	T	73096839	4	4	46	1	0	0	0	0	0	1	0	0	14465	827	29	3	1091	3	SLC16A5	17	73096839	Nonsense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	145	73096839	8098371	78	4309			1	8		5	5	4009	C		9.428719e-10
SLC16A5	9121	broad.mit.edu	37	chr17	73100228	73100228	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gccctggagcgggatcttttCttggaagccaaagacggtcc	13	11	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr17:73100228C>G	ENST00000450736.2	+	5	1732	c.1317C>G	c.(1315-1317)ttC>ttG	p.F439L	SLC16A5_ENST00000538213.2_Missense_Mutation_p.F479L|SLC16A5_ENST00000580123.1_Missense_Mutation_p.F439L|SLC16A5_ENST00000329783.4_Missense_Mutation_p.F439L			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	439					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GGGATCTTTTCTTGGAAGCCA	0.572													15	65					0	0	1	0	0	G	73100228	C	G	73100228	3	3	46	1	0	0	0	0	1	0	0	0	14465	912	32	2	1331	2	SLC16A5	17	73100228	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	3389	73100228	8094982	79	4310			1	8		5	5	4009	C		9.428719e-10
SERPINB8	5271	broad.mit.edu	37	chr18	61654204	61654204	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ttttccttcccagattaaagCtggaggagagttatgacttg	10	7	0	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr18:61654204C>T	ENST00000397985.2	+	7	1073	c.817C>T	c.(817-819)Ctg>Ttg	p.L273L	SERPINB8_ENST00000542677.1_Silent_p.L91L|SERPINB8_ENST00000493661.1_Intron|SERPINB8_ENST00000353706.2_Silent_p.L273L	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	273					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				CAGATTAAAGCTGGAGGAGAG	0.398													19	53					0	0	1	0	0	T	61654204	C	T	61654204	2	4	46	1	0	0	0	0	0	0	0	1	14160	796	28	3		3	SERPINB8	18	61654204	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		61654204	16423044	80	4311										
AKAP8	10270	broad.mit.edu	37	chr19	15472610	15472610	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tgacgccgcttctcaattttCttatttctgtttacaatgta	5	9	3	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr19:15472610C>G	ENST00000269701.2	-	11	1386	c.1326G>C	c.(1324-1326)aaG>aaC	p.K442N		NM_005858.3	NP_005849.1	O43823	AKAP8_HUMAN	A kinase (PRKA) anchor protein 8	442					signal transduction	nuclear matrix				breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)	26						TCTCAATTTTCTTATTTCTGT	0.453													26	21					0	0	1	0	0	G	15472610	C	G	15472610	3	3	46	1	0	0	0	0	1	0	0	0	454	912	32	2	768	2	AKAP8	19	15472610	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		15472610	43656373	81	4312										
ZNF283	284349	broad.mit.edu	37	chr19	44352095	44352095	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gtcgtggctatcacctttctCaacatcagaaaatccatact	5	12	3	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr19:44352095C>T	ENST00000324461.7	+	7	1639	c.1342C>T	c.(1342-1344)Caa>Taa	p.Q448*	ZNF283_ENST00000588797.1_Nonsense_Mutation_p.Q309*	NM_181845.1	NP_862828.1	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8		Prostate(69;0.0352)				TCACCTTTCTCAACATCAGAA	0.393													39	58					0	0	1	0	0	T	44352095	C	T	44352095	4	4	46	1	0	0	0	0	0	1	0	0	17877	827	29	3	1356	3	ZNF283	19	44352095	Nonsense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	28879485	44352095	14776888	82	4313										
ZNF749	388567	broad.mit.edu	37	chr19	57953359	57953359	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	caatgtgatgttggagaactTtgcgcttttgtcatcagtag	11	6	2	2			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr19:57953359T>A	ENST00000334181.4	+	2	372	c.122T>A	c.(121-123)tTt>tAt	p.F41Y	AC004076.9_ENST00000596831.1_Intron	NM_001023561.2	NP_001018855.2	O43361	ZN749_HUMAN	zinc finger protein 749	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|lung(3)|prostate(1)	13		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TTGGAGAACTTTGCGCTTTTG	0.458													9	224					0	0	1	0	0	A	57953359	T	A	57953359	3	1	46	1	0	0	0	0	1	0	0	0	18180	1841	64	4	128	4	ZNF749	19	57953359	Missense_Mutation	SNP	T	TCGA-ND-A4W6-01A-11D-A28R-08	13601264	57953359	1175624	83	4314										
PREX1	57580	broad.mit.edu	37	chr20	47269915	47269915	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	ttaccagggcctcttcgcgcCgactccggaatgcctggaag	12	14	1	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr20:47269915C>T	ENST00000396220.1	-	20	2352	c.2330G>A	c.(2329-2331)cGg>cAg	p.R777Q	PREX1_ENST00000371941.3_Missense_Mutation_p.R777Q			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	777					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCTTCGCGCCGACTCCGGAA	0.582													65	118					0	0	1	0	0	T	47269915	C	T	47269915	3	4	46	1	0	0	0	0	1	0	0	0	12527	652	23	1	2733	1	PREX1	20	47269915	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		47269915	15755605	84	4315										
SLCO4A1	28231	broad.mit.edu	37	chr20	61288206	61288206	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tcatcacctccctggagcgcCgctatgacctgcacagctac	8	17	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr20:61288206C>T	ENST00000217159.1	+	2	605	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.R134C	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	134					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CCTGGAGCGCCGCTATGACCT	0.612													7	71					0	0	1	0	0	T	61288206	C	T	61288206	3	4	46	1	0	0	0	0	1	0	0	0	14783	652	23	1	402	1	SLCO4A1	20	61288206	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	14018291	61288206	1737314	85	4316										
TPTE	7179	broad.mit.edu	37	chr21	10921996	10921996	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aaccatagttcctgttctatCtagaaaagaaaagaagttag	7	6	2	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr21:10921996C>T	ENST00000298232.7	-	17	1341		c.e17-1		TPTE_ENST00000361285.4_Splice_Site|TPTE_ENST00000342420.5_Splice_Site|TPTE_ENST00000415664.2_Splice_Site	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTGTTCTATCTAGAAAAGAA	0.313													15	41					0	0	1	0	0	T	10921996	C	T	10921996	5	4	46	1	0	0	0	0	0	0	1	0	16490	927	32	3	656	3	TPTE	21	10921996	Splice_Site	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		10921996	37207899	86	4317										
BAGE2	85319	broad.mit.edu	37	chr21	11093134	11093135	+	RNA	INS	-	-	C													0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	catttatctgttctcccctaINSccccccacaacgctatctac					rs141935972		TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr21:11093134_11093135insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTCTCCCCTACCCCCCACAAC	0.401													7	10	---	---	---	---						C	11093135	-	C	11093134	6	5	46	0	1	1	1	0	0	0	0	0	1290	406	14	0		0	BAGE2	21	11093134	RNA	INS	-	TCGA-ND-A4W6-01A-11D-A28R-08	171138	11093134	37036761	87	4318										
TRPM2	7226	broad.mit.edu	37	chr21	45811363	45811363	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	tcccgagcgcccggcttgcgCgcccgcggcgccccgcctgc	14	22	0	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr21:45811363C>T	ENST00000397928.1	+	11	2094	c.1649C>T	c.(1648-1650)gCg>gTg	p.A550V	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.A550V|TRPM2_ENST00000397932.2_Missense_Mutation_p.A550V|TRPM2_ENST00000300481.9_Intron	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	550						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCGGCTTgcgcgcccgcggcg	0.687													12	19					0	0	1	0	0	T	45811363	C	T	45811363	3	4	46	1	0	0	0	0	1	0	0	0	16646	768	27	1	1691	1	TRPM2	21	45811363	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	34718229	45811363	2318532	88	4319										
LZTR1	8216	broad.mit.edu	37	chr22	21344752	21344752	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	cgggacaagatgtttgtattCtctgggcaaagcggagccaa	13	8	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr22:21344752C>G	ENST00000215739.8	+	8	1088	c.729C>G	c.(727-729)ttC>ttG	p.F243L	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Missense_Mutation_p.F224L	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	243					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGTTTGTATTCTCTGGGCAAA	0.567													92	29					0	0	1	0	0	G	21344752	C	G	21344752	3	3	46	1	0	0	0	0	1	0	0	0	9182	912	32	2	759	2	LZTR1	22	21344752	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08		21344752	29959814	89	4320										
CABIN1	23523	broad.mit.edu	37	chr22	24561546	24561546	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gtcctggcgcagcgggccttCatcctcactgtgaaggtgct	13	13	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chr22:24561546C>T	ENST00000398319.2	+	31	5344	c.4959C>T	c.(4957-4959)ttC>ttT	p.F1653F	CABIN1_ENST00000263119.5_Silent_p.F1653F|CABIN1_ENST00000337989.7_Silent_p.F78F|CABIN1_ENST00000405822.2_Silent_p.F1574F	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1653					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AGCGGGCCTTCATCCTCACTG	0.602													27	9					0	0	1	0	0	T	24561546	C	T	24561546	2	4	46	1	0	0	0	0	0	0	0	1	2546	825	29	3		3	CABIN1	22	24561546	Silent	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	3216794	24561546	26743020	90	4321										
ZC4H2	55906	broad.mit.edu	37	chrX	64141740	64141740	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	gtcggagttcctccacatggGccatcttctcctgtagcaga	10	13	2	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chrX:64141740G>A	ENST00000545618.1	-	3	730	c.167C>T	c.(166-168)gCc>gTc	p.A56V	ZC4H2_ENST00000337990.2_Missense_Mutation_p.A38V|ZC4H2_ENST00000374839.3_Missense_Mutation_p.A61V|ZC4H2_ENST00000488608.1_5'UTR|ZC4H2_ENST00000447788.2_Missense_Mutation_p.A61V			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	61							metal ion binding|protein binding			endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CTCCACATGGGCCATCTTCTC	0.507													7	20					0	0	1	0	0	A	64141740	G	A	64141740	3	1	46	1	0	0	0	0	1	0	0	0	17636	1203	42	3	527	3	ZC4H2	23	64141740	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08		64141740	91128820	91	4322										
HDAC8	55869	broad.mit.edu	37	chrX	71684476	71684476	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	agacacttgccaattcccacTggagtcatgttaaaggagca	9	10	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chrX:71684476T>C	ENST00000373573.3	-	8	1184	c.843A>G	c.(841-843)ccA>ccG	p.P281P	HDAC8_ENST00000373589.4_Silent_p.P190P|HDAC8_ENST00000429103.2_Silent_p.P86P|HDAC8_ENST00000373583.1_Intron	NM_018486.2	NP_060956.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	281	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	CAATTCCCACTGGAGTCATGT	0.448													16	84					0	0	1	0	0	C	71684476	T	C	71684476	2	2	46	1	0	0	0	0	0	0	0	1	7053	1567	55	4		4	HDAC8	23	71684476	Silent	SNP	T	TCGA-ND-A4W6-01A-11D-A28R-08	7542736	71684476	83586084	92	4323										
TAF7L	54457	broad.mit.edu	37	chrX	100531442	100531442	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	atcctcatcctcatcctcatCttcatcatcctcatcctcat	0	18	8	0			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chrX:100531442C>G	ENST00000372907.3	-	10	1035	c.1024G>C	c.(1024-1026)Gat>Cat	p.D342H	TAF7L_ENST00000356784.1_Missense_Mutation_p.D256H|TAF7L_ENST00000324762.6_Intron|TAF7L_ENST00000372905.2_Intron	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	342	Glu-rich.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						tcatcctcatcttcatcatcc	0.418													30	36					0	0	1	0	0	G	100531442	C	G	100531442	3	3	46	1	0	0	0	0	1	0	0	0	15589	913	32	2	380	2	TAF7L	23	100531442	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	28846966	100531442	54739118	93	4324										
RNF128	79589	broad.mit.edu	37	chrX	105937564	105937564	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	aaaaattcaaacagcgggcaGaagaaatgctgatgctgttg	11	6	1	3			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chrX:105937564G>A	ENST00000324342.3	+	1	497	c.332G>A	c.(331-333)aGa>aAa	p.R111K		NM_024539.3	NP_078815.3	Q8TEB7	RN128_HUMAN	ring finger protein 128, E3 ubiquitin protein ligase	137	PA.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						ACAGCGGGCAGAAGAAATGCT	0.383													13	25					0	0	1	0	0	A	105937564	G	A	105937564	3	1	46	1	0	0	0	0	1	0	0	0	13487	942	33	3	334	3	RNF128	23	105937564	Missense_Mutation	SNP	G	TCGA-ND-A4W6-01A-11D-A28R-08	5406122	105937564	49332996	94	4325										
MAGEC2	51438	broad.mit.edu	37	chrX	141290899	141290899	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.263157894736842	25	0.000204598430030377	2.58020425005158	4.82362394535958	1.80520471894518	1	1	15	attcataatatggaggagaaCtgtggggcacctcccgatac	11	9	1	1			TCGA-ND-A4W6-01A-11D-A28R-08	TCGA-ND-A4W6-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72a15de6-7832-4e02-a888-999ad45192ad	6ef05129-3199-4859-9ae4-e0b4d7558fd5	g.chrX:141290899C>G	ENST00000247452.3	-	3	1222	c.875G>C	c.(874-876)aGt>aCt	p.S292T		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	292	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TGGAGGAGAACTGTGGGGCAC	0.498										HNSCC(46;0.14)			24	59					0	0	1	0	0	G	141290899	C	G	141290899	3	3	46	1	0	0	0	0	1	0	0	0	9230	565	20	5	250	5	MAGEC2	23	141290899	Missense_Mutation	SNP	C	TCGA-ND-A4W6-01A-11D-A28R-08	35353335	141290899	13979661	95	4326										
ARHGEF10L	55160	broad.mit.edu	37	chr1	17966763	17966763	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cccctgagcaagatttcctgGgtcaacaggttacatttggc	10	11	1	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:17966763G>T	ENST00000361221.3	+	21	2397	c.2238G>T	c.(2236-2238)tgG>tgT	p.W746C	ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.W707C|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.W707C|ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.W449C|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.W741C|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.W519C	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	746					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AGATTTCCTGGGTCAACAGGT	0.572													12	0					2.27111e-07	2.52038e-07	1	1	0	T	17966763	G	T	17966763	3	4	47	1	0	0	0	0	1	0	0	0	892	1241	43	5	2316	5	ARHGEF10L	1	17966763	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		17966763	231283858	1	4327										
CYP4X1	260293	broad.mit.edu	37	chr1	47495700	47495700	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	atggagaagcttgaggaaatTattgaaaaataccctcgtgc	10	6	0	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:47495700T>C	ENST00000371901.3	+	2	466	c.216T>C	c.(214-216)atT>atC	p.I72I	CYP4X1_ENST00000538609.1_Silent_p.I71I	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	72						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						TTGAGGAAATTATTGAAAAAT	0.418													33	40					0	0	1	0	0	C	47495700	T	C	47495700	2	2	47	1	0	0	0	0	0	0	0	1	4216	1742	61	4		4	CYP4X1	1	47495700	Silent	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08	29528937	47495700	201754921	2	4328										
NRD1	4898	broad.mit.edu	37	chr1	52258048	52258048	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gcatctcctttatgcacttaCcacaagcagctccataagcg	6	14	1	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:52258048C>A	ENST00000354831.7	-	27	3217		c.e27+1		NRD1_ENST00000352171.7_Splice_Site|NRD1_ENST00000539524.1_Splice_Site|NRD1_ENST00000485608.1_Splice_Site	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)						cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TATGCACTTACCACAAGCAGC	0.502													14	23					1.15088e-07	1.30912e-07	1	1	0	A	52258048	C	A	52258048	5	1	47	1	0	0	0	0	0	0	1	0	10692	521	18	5	659	5	NRD1	1	52258048	Splice_Site	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	4762348	52258048	196992573	3	4329										
PCSK9	255738	broad.mit.edu	37	chr1	55527145	55527145	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cagtgcgtgggccacagggaGgccagcatccacgcttcctg	14	14	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:55527145G>A	ENST00000302118.5	+	11	2069	c.1779G>A	c.(1777-1779)gaG>gaA	p.E593E	PCSK9_ENST00000490692.1_3'UTR|PCSK9_ENST00000543384.1_3'UTR	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	593					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GCCACAGGGAGGCCAGCATCC	0.652													9	8					0	0	1	0	0	A	55527145	G	A	55527145	2	1	47	1	0	0	0	0	0	0	0	1	11652	991	35	3		3	PCSK9	1	55527145	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	3269097	55527145	193723476	4	4330										
ASTN1	460	broad.mit.edu	37	chr1	176838076	176838076	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cccggtgtaaggtgggggaaCccagatccaggagggtgttg	18	8	0	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:176838076C>A	ENST00000367654.2	-	22	3588	c.3575G>T	c.(3574-3576)gGt>gTt	p.G1192V	ASTN1_ENST00000367657.3_Missense_Mutation_p.G1184V|ASTN1_ENST00000424564.2_Missense_Mutation_p.G1184V|ASTN1_ENST00000361833.2_Missense_Mutation_p.G1184V			O14525	ASTN1_HUMAN	astrotactin 1	1192					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGTGGGGGAACCCAGATCCAG	0.512													29	46					8.58068e-18	1.00108e-17	1	1	0	A	176838076	C	A	176838076	3	1	47	1	0	0	0	0	1	0	0	0	1063	507	18	5	345	5	ASTN1	1	176838076	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	121310931	176838076	72412545	5	4331										
SUSD4	55061	broad.mit.edu	37	chr1	223402701	223402701	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cgggtggcagacgaaatctcCgtgactcaccattggaggta	13	10	2	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:223402701C>T	ENST00000343846.3	-	5	1387	c.754G>A	c.(754-756)Gga>Aga	p.G252R	SUSD4_ENST00000478605.1_Intron|SUSD4_ENST00000454695.2_Missense_Mutation_p.G92R|SUSD4_ENST00000366878.4_Missense_Mutation_p.G252R			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	252	Sushi 4.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		ACGAAATCTCCGTGACTCACC	0.532													3	27					0	0	1	0	0	T	223402701	C	T	223402701	3	4	47	1	0	0	0	0	1	0	0	0	15465	661	23	1	734	1	SUSD4	1	223402701	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	46564625	223402701	25847920	6	4332										
EFCAB2	84288	broad.mit.edu	37	chr1	245246946	245246946	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tttagattcagctaaacgtgGgtttcttactaaggacgagc	10	7	2	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:245246946G>T	ENST00000366522.2	+	7	878	c.737G>T	c.(736-738)gGg>gTg	p.G246V	EFCAB2_ENST00000487845.1_3'UTR|EFCAB2_ENST00000447569.2_Missense_Mutation_p.G110V|EFCAB2_ENST00000366523.1_Missense_Mutation_p.G110V			Q5VUJ9	EFCB2_HUMAN	EF-hand calcium binding domain 2	246	EF-hand 2.						calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|stomach(2)	13	all_cancers(71;2.93e-06)|all_epithelial(71;2.13e-05)|all_lung(81;0.0337)|Lung NSC(105;0.0472)|Ovarian(71;0.0584)|Breast(184;0.0716)|all_neural(11;0.0982)		OV - Ovarian serous cystadenocarcinoma(106;0.015)			GCTAAACGTGGGTTTCTTACT	0.294													4	2					0.00024832	0.000265848	1	1	0	T	245246946	G	T	245246946	3	4	47	1	0	0	0	0	1	0	0	0	4960	1232	43	5	351	5	EFCAB2	1	245246946	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	21844245	245246946	4003675	7	4333										
ZC3H6	376940	broad.mit.edu	37	chr2	113089467	113089467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ggttatgaaggattcacatgCatcaaagggtgcccctcact	10	10	3	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:113089467C>T	ENST00000409871.1	+	12	3373	c.2972C>T	c.(2971-2973)gCa>gTa	p.A991V	ZC3H6_ENST00000343936.4_Missense_Mutation_p.A991V	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	991							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						GATTCACATGCATCAAAGGGT	0.473													15	18					0	0	1	0	0	T	113089467	C	T	113089467	3	4	47	1	0	0	0	0	1	0	0	0	17629	710	25	3	3018	3	ZC3H6	2	113089467	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08		113089467	130109906	8	4334										
SCN3A	6328	broad.mit.edu	37	chr2	166019317	166019317	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tctttaccgactggatcaggGcccccacaatggtctttaaa	8	12	3	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:166019317G>A	ENST00000360093.3	-	8	1207	c.716C>T	c.(715-717)gCc>gTc	p.A239V	SCN3A_ENST00000283254.7_Missense_Mutation_p.A239V|SCN3A_ENST00000409101.3_Missense_Mutation_p.A239V	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	239						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CTGGATCAGGGCCCCCACAAT	0.453													39	80					0	0	1	0	0	A	166019317	G	A	166019317	3	1	47	1	0	0	0	0	1	0	0	0	13971	1203	42	3	5370	3	SCN3A	2	166019317	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	52929850	166019317	77180056	9	4335										
FAM171B	165215	broad.mit.edu	37	chr2	187615972	187615972	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agtttctcttcctcttctacGtctgaatgatataagtgcag	7	9	4	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:187615972G>A	ENST00000304698.5	+	5	1039	c.836G>A	c.(835-837)cGt>cAt	p.R279H		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	279						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CCTCTTCTACGTCTGAATGAT	0.363													9	27					0	0	1	0	0	A	187615972	G	A	187615972	3	1	47	1	0	0	0	0	1	0	0	0	5520	1145	40	1	854	1	FAM171B	2	187615972	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	21596655	187615972	55583401	10	4336										
PLCL1	5334	broad.mit.edu	37	chr2	198950127	198950127	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cattgcaaatgagtacccagAggattttgttaattataata	7	5	0	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:198950127A>T	ENST00000428675.1	+	2	2284	c.1886A>T	c.(1885-1887)gAg>gTg	p.E629V	PLCL1_ENST00000437704.2_Missense_Mutation_p.E531V	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	629	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GAGTACCCAGAGGATTTTGTT	0.368													7	24					0	0	1	0	0	T	198950127	A	T	198950127	3	4	47	1	0	0	0	0	1	0	0	0	12086	304	11	4	1892	4	PLCL1	2	198950127	Missense_Mutation	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08	11334155	198950127	44249246	11	4337										
ZNF142	7701	broad.mit.edu	37	chr2	219508021	219508021	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tcgggggagcagagtccccaTtgctcaacggggacacatca	13	12	2	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:219508021T>C	ENST00000411696.2	-	7	3997	c.3218A>G	c.(3217-3219)aAt>aGt	p.N1073S	ZNF142_ENST00000449707.1_Missense_Mutation_p.N1073S			P52746	ZN142_HUMAN	zinc finger protein 142	1073					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGAGTCCCCATTGCTCAACGG	0.602													11	50					0	0	1	0	0	C	219508021	T	C	219508021	3	2	47	1	0	0	0	0	1	0	0	0	17788	1493	52	4	1857	4	ZNF142	2	219508021	Missense_Mutation	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08	20557894	219508021	23691352	12	4338										
KAT2B	8850	broad.mit.edu	37	chr3	20082165	20082165	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ctgcagcgggcacggccgaaGgaccgggaggcggtggctcg	20	12	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:20082165G>T	ENST00000263754.4	+	1	651	c.196G>T	c.(196-198)Gga>Tga	p.G66*		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	66					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						CACGGCCGAAGGACCGGGAGG	0.746													5	17					5.9392e-07	6.51165e-07	1	1	0	T	20082165	G	T	20082165	4	4	47	1	0	0	0	0	0	1	0	0	8025	1001	35	5	198	5	KAT2B	3	20082165	Nonsense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		20082165	177940265	13	4339										
TRIM71	131405	broad.mit.edu	37	chr3	32933116	32933116	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agctgtggaccaggaagggcGcatcattgtggcggattcca	15	9	1	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:32933116G>A	ENST00000383763.4	+	4	2483	c.2420G>A	c.(2419-2421)cGc>cAc	p.R807H		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	807					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAGGAAGGGCGCATCATTGTG	0.597													4	116					0	0	1	0	0	A	32933116	G	A	32933116	3	1	47	1	0	0	0	0	1	0	0	0	16604	1087	38	1	2434	1	TRIM71	3	32933116	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	12850951	32933116	165089314	14	4340										
SCN11A	11280	broad.mit.edu	37	chr3	38949535	38949535	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ccttttcttattaccaaagaGctttctcttttttggggtaa	6	8	2	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:38949535G>C	ENST00000302328.3	-	10	1576	c.1378C>G	c.(1378-1380)Ctc>Gtc	p.L460V	SCN11A_ENST00000456224.3_Missense_Mutation_p.L460V|SCN11A_ENST00000444237.2_Missense_Mutation_p.L460V|SCN11A_ENST00000450244.1_Missense_Mutation_p.L460V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	460					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTACCAAAGAGCTTTCTCTTT	0.393													32	42					0	0	1	0	0	C	38949535	G	C	38949535	3	2	47	1	0	0	0	0	1	0	0	0	13966	971	34	5	4065	5	SCN11A	3	38949535	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	6016419	38949535	159072895	15	4341										
PARP14	54625	broad.mit.edu	37	chr3	122420030	122420030	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gaaagctgccctaccaccacGtgatccatgcagtggggccc	11	15	0	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:122420030G>A	ENST00000474629.2	+	6	2895	c.2629G>A	c.(2629-2631)Gtg>Atg	p.V877M		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	877	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		CTACCACCACGTGATCCATGC	0.577													10	46					0	0	1	0	0	A	122420030	G	A	122420030	3	1	47	1	0	0	0	0	1	0	0	0	11504	1145	40	1	2651	1	PARP14	3	122420030	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	83470495	122420030	75602400	16	4342										
SMC4	10051	broad.mit.edu	37	chr3	160137275	160137275	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gaagtagggggaaagtccttGatgcaataattcaagaaaaa	11	4	1	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:160137275G>C	ENST00000357388.3	+	12	2252	c.1801G>C	c.(1801-1803)Gat>Cat	p.D601H	SMC4_ENST00000344722.5_Missense_Mutation_p.D601H|SMC4_ENST00000469762.1_Missense_Mutation_p.D576H|SMC4_ENST00000462787.1_Missense_Mutation_p.D601H|SMC4_ENST00000360111.2_Missense_Mutation_p.D601H|RP11-432B6.3_ENST00000483754.1_Intron	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	601	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAAAGTCCTTGATGCAATAAT	0.338													66	39					0	0	1	0	0	C	160137275	G	C	160137275	3	2	47	1	0	0	0	0	1	0	0	0	14838	1290	45	2	1843	2	SMC4	3	160137275	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	37717245	160137275	37885155	17	4343										
EIF4G1	1981	broad.mit.edu	37	chr3	184046479	184046480	+	Frame_Shift_Ins	INS	-	-	TACCTAGCGGA													0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	acatcccccacgtgtggctcINStacctagcggaactggtaac							TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:184046479_184046480insTACCTAGCGGA	ENST00000342981.4	+	26	4431_4432	c.4017_4018insTACCTAGCGGA	c.(4015-4020)ctacctfs	p.P1340fs	EIF4G1_ENST00000392537.2_Frame_Shift_Ins_p.P1252fs|EIF4G1_ENST00000434061.2_Frame_Shift_Ins_p.P1144fs|EIF4G1_ENST00000435046.2_Frame_Shift_Ins_p.P1143fs|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000352767.3_Frame_Shift_Ins_p.P1346fs|EIF4G1_ENST00000411531.1_Frame_Shift_Ins_p.P1300fs|EIF4G1_ENST00000414031.1_Frame_Shift_Ins_p.P1299fs|EIF4G1_ENST00000382330.3_Frame_Shift_Ins_p.P1346fs|EIF4G1_ENST00000350481.5_Frame_Shift_Ins_p.P1175fs|EIF4G1_ENST00000424196.1_Frame_Shift_Ins_p.P1346fs|EIF4G1_ENST00000441154.1_Frame_Shift_Ins_p.P1176fs|EIF4G1_ENST00000319274.6_Frame_Shift_Ins_p.P1339fs|EIF4G1_ENST00000346169.2_Frame_Shift_Ins_p.P1339fs|EIF4G1_ENST00000427845.1_Frame_Shift_Ins_p.P1253fs	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1339	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity	p.L1338L(1)		central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACGTGTGGCTCTACCTAGCGGA	0.525													12	284	---	---	---	---						TACCTAGCGGA	184046480	-	TACCTAGCGGA	184046479	7	5	47	1	0	1	1	0	0	0	0	0	5064	900	32	0	4112	0	EIF4G1	3	184046479	Frame_Shift_Ins	INS	-	TCGA-ND-A4WA-01A-12D-A28R-08	23909204	184046479	13975951	18	4344										
OSTN	344901	broad.mit.edu	37	chr3	190967905	190967905	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	accggctttcaaattccagaGgctaattgattccaattgtg	8	9	1	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:190967905G>A	ENST00000339051.1	+	3	397	c.397G>A	c.(397-399)Ggc>Agc	p.G133S	OSTN_ENST00000445281.1_Intron	NM_198184.1	NP_937827.1	P61366	OSTN_HUMAN	osteocrin	133					cell differentiation|multicellular organismal development|ossification		hormone activity			kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|skin(2)	13	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		AAATTCCAGAGGCTAATTGAT	0.368													43	60					0	0	1	0	0	A	190967905	G	A	190967905	3	1	47	1	0	0	0	0	1	0	0	0	11345	1000	35	3	407	3	OSTN	3	190967905	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	6921426	190967905	7054525	19	4345										
IL2	3558	broad.mit.edu	37	chr4	123374885	123374885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ctttagttccagaactattaCgttgatattgctgattaagt	7	6	0	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:123374885C>T	ENST00000226730.4	-	3	615	c.331G>A	c.(331-333)Gta>Ata	p.V111I		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	111					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity	p.V111L(1)		endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		AGAACTATTACGTTGATATTG	0.353			T	TNFRSF17	intestinal T-cell lymphoma								16	18					0	0	1	0	0	T	123374885	C	T	123374885	3	4	47	1	0	0	0	0	1	0	0	0	7709	536	19	1	138	1	IL2	4	123374885	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08		123374885	67779391	20	4346										
LARP1B	55132	broad.mit.edu	37	chr4	129128488	129128488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cacagtctattgacccaaaaCttcaggaatacctctgtagt	6	11	3	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:129128488C>T	ENST00000326639.6	+	19	2708	c.2497C>T	c.(2497-2499)Ctt>Ttt	p.L833F	LARP1B_ENST00000264584.5_Missense_Mutation_p.L774F|LARP1B_ENST00000354456.3_Missense_Mutation_p.L252F|LARP1B_ENST00000506199.1_3'UTR|LARP1B_ENST00000441387.1_3'UTR	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	833							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TGACCCAAAACTTCAGGAATA	0.313													10	9					0	0	1	0	0	T	129128488	C	T	129128488	3	4	47	1	0	0	0	0	1	0	0	0	8667	565	20	3	2697	3	LARP1B	4	129128488	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	5753603	129128488	62025788	21	4347										
MTNR1A	4543	broad.mit.edu	37	chr4	187455100	187455100	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gatcctaggcaccatgctggCggggtcagaggccacggcca	15	13	1	1	rs148793802		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:187455100C>T	ENST00000307161.5	-	2	997	c.796G>A	c.(796-798)Gcc>Acc	p.A266T	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	266					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	ACCATGCTGGCGGGGTCAGAG	0.507													39	49					0	0	1	0	0	T	187455100	C	T	187455100	3	4	47	1	0	0	0	0	1	0	0	0	9998	768	27	1	260	1	MTNR1A	4	187455100	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	58326612	187455100	3699176	22	4348										
SLC12A7	10723	broad.mit.edu	37	chr5	1093658	1093658	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gtggcagtaccttggcctccCgccgccggctctcctcgtcc	11	19	1	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr5:1093658C>A	ENST00000264930.5	-	3	375	c.332G>T	c.(331-333)cGg>cTg	p.R111L		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	111					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CTTGGCCTCCCGCCGCCGGCT	0.662													4	1					0.00909568	0.00930008	1	1	0	A	1093658	C	A	1093658	3	1	47	1	0	0	0	0	1	0	0	0	14442	652	23	5	3007	5	SLC12A7	5	1093658	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08		1093658	179821602	23	4349										
ADCY2	108	broad.mit.edu	37	chr5	7709333	7709333	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ctcaccccaagggagaacgaCggagcccccagcatctcttc	9	17	2	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr5:7709333C>T	ENST00000338316.4	+	10	1500	c.1411C>T	c.(1411-1413)Cgg>Tgg	p.R471W	RP11-711G10.1_ENST00000514105.2_RNA|ADCY2_ENST00000537121.1_Missense_Mutation_p.R291W	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	471					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGGAGAACGACGGAGCCCCCA	0.587													15	24					0	0	1	0	0	T	7709333	C	T	7709333	3	4	47	1	0	0	0	0	1	0	0	0	293	527	19	1	1449	1	ADCY2	5	7709333	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	6615675	7709333	173205927	24	4350										
SQSTM1	8878	broad.mit.edu	37	chr5	179251284	179251284	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	actggagcccacgtcctcctCgtgcaggggaggcccgccct	13	17	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr5:179251284C>T	ENST00000389805.4	+	4	812	c.634C>T	c.(634-636)Cgt>Tgt	p.R212C	SQSTM1_ENST00000402874.3_Missense_Mutation_p.R128C|SQSTM1_ENST00000360718.5_Missense_Mutation_p.R128C|SQSTM1_ENST00000376929.3_Missense_Mutation_p.R128C|SQSTM1_ENST00000510187.1_Missense_Mutation_p.R212C	NM_003900.4	NP_003891.1	Q13501	SQSTM_HUMAN	sequestosome 1	212	Interaction with GABRR3 (By similarity).|LIM protein-binding (LB).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACGTCCTCCTCGTGCAGGGGA	0.622													19	29					0	0	1	0	0	T	179251284	C	T	179251284	3	4	47	1	0	0	0	0	1	0	0	0	15185	884	31	1	648	1	SQSTM1	5	179251284	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	171541951	179251284	1663976	25	4351										
HIST1H3G	8355	broad.mit.edu	37	chr6	26271424	26271424	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cgttggaaaggcaacttgcgGatcagcagctcagtcgactt	12	10	2	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:26271424G>A	ENST00000305910.3	-	1	188	c.189C>T	c.(187-189)atC>atT	p.I63I		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	63					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						GCAACTTGCGGATCAGCAGCT	0.617													49	96					0	0	1	0	0	A	26271424	G	A	26271424	2	1	47	1	0	0	0	0	0	0	0	1	7201	1164	41	3		3	HIST1H3G	6	26271424	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		26271424	144843643	26	4352										
ICK	22858	broad.mit.edu	37	chr6	52884097	52884097	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ccaaaccaaagtctgcaattTtcacaagttctggtcccatg	6	12	3	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:52884097T>G	ENST00000356971.3	-	7	908	c.419A>C	c.(418-420)aAa>aCa	p.K140T	ICK_ENST00000350082.5_Missense_Mutation_p.K140T	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	140	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					GTCTGCAATTTTCACAAGTTC	0.388													8	27					0	0	1	0	0	G	52884097	T	G	52884097	3	3	47	1	0	0	0	0	1	0	0	0	7527	1841	64	4	1515	4	ICK	6	52884097	Missense_Mutation	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08	26612673	52884097	118230970	27	4353										
MICAL1	64780	broad.mit.edu	37	chr6	109775014	109775014	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gcgccagctccacagcgaccCgcagcccgcaaggtccagca	11	19	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:109775014C>T	ENST00000368952.4	-	3	640	c.350G>A	c.(349-351)cGg>cAg	p.R117Q	MICAL1_ENST00000358577.3_Missense_Mutation_p.R98Q|MICAL1_ENST00000358807.3_Missense_Mutation_p.R98Q			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	98					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CACAGCGACCCGCAGCCCGCA	0.657													66	35					0	0	1	0	0	T	109775014	C	T	109775014	3	4	47	1	0	0	0	0	1	0	0	0	9616	652	23	1	3002	1	MICAL1	6	109775014	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	56890917	109775014	61340053	28	4354										
FABP7	2173	broad.mit.edu	37	chr6	123102370	123102370	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	acaattctccattcttccttGtttttttctcctctccgcac	2	15	4	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:123102370G>T	ENST00000356535.4	+	3	415	c.379G>T	c.(379-381)Gtt>Ttt	p.V127F	FABP7_ENST00000368444.3_Intron			O15540	FABP7_HUMAN	fatty acid binding protein 7, brain	0	Fatty acid binding.				negative regulation of cell proliferation	cytoplasm	lipid binding|transporter activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5				GBM - Glioblastoma multiforme(226;0.226)	Alpha-Linolenic Acid(DB00132)|gamma-Homolinolenic acid(DB00154)|Icosapent(DB00159)	ATTCTTCCTTGTTTTTTTCTC	0.398													3	19					1	1	1	1	0	T	123102370	G	T	123102370	3	4	47	1	0	0	0	0	1	0	0	0	5393	1392	48	5		5	FABP7	6	123102370	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	13327356	123102370	48012697	29	4355										
SEMA3D	223117	broad.mit.edu	37	chr7	84628909	84628909	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	atctgttcgcagtactggtcGaggctgaagtttgggctgct	14	8	1	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr7:84628909G>A	ENST00000284136.6	-	17	2224	c.2181C>T	c.(2179-2181)ctC>ctT	p.L727L	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	727					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AGTACTGGTCGAGGCTGAAGT	0.512													20	42					0	0	1	0	0	A	84628909	G	A	84628909	2	1	47	1	0	0	0	0	0	0	0	1	14080	1045	37	1		1	SEMA3D	7	84628909	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		84628909	74509754	30	4356										
PKHD1L1	93035	broad.mit.edu	37	chr8	110457553	110457553	+	Frame_Shift_Del	DEL	A	A	-													0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ttagtgttgtggtgggaagtAaaggcttggctctgggaaac							TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr8:110457553delA	ENST00000378402.5	+	38	5559	c.5455delA	c.(5455-5457)aafs	p.K1819fs		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1819	IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGTGGGAAGTAAAGGCTTGGC	0.478										HNSCC(38;0.096)			20	50	---	---	---	---						-	110457553	A	-	110457553	7	5	47	1	0	1	0	1	0	0	0	0	12019	363	13	0	5605	0	PKHD1L1	8	110457553	Frame_Shift_Del	DEL	A	TCGA-ND-A4WA-01A-12D-A28R-08		110457553	35906469	31	4357										
OR51E2	81285	broad.mit.edu	37	chr11	4703777	4703777	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agaaagaggtacatcggagcGtgcaggctgcgttccgtcct	14	10	0	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr11:4703777G>A	ENST00000396950.3	-	2	404	c.165C>T	c.(163-165)caC>caT	p.H55H		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		ACATCGGAGCGTGCAGGCTGC	0.517													6	77					0	0	1	0	0	A	4703777	G	A	4703777	2	1	47	1	0	0	0	0	0	0	0	1	11142	1136	40	1		1	OR51E2	11	4703777	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		4703777	130302739	32	4358										
ABCC8	6833	broad.mit.edu	37	chr11	17419890	17419890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ggggaatagcacttgccattCggacttccagccatctgttg	11	11	1	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr11:17419890C>T	ENST00000302539.4	-	30	3877	c.3752G>A	c.(3751-3753)cGa>cAa	p.R1251Q	ABCC8_ENST00000389817.3_Missense_Mutation_p.R1250Q	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1250	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity	p.R1250Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACTTGCCATTCGGACTTCCAG	0.542													24	17					0	0	1	0	0	T	17419890	C	T	17419890	3	4	47	1	0	0	0	0	1	0	0	0	58	884	31	1	1036	1	ABCC8	11	17419890	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	12716113	17419890	117586626	33	4359										
CLEC12A	160364	broad.mit.edu	37	chr12	10132100	10132100	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	aatagccaccaaattatgtcGtgagctatatagcaaagaac	7	8	0	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr12:10132100G>A	ENST00000304361.4	+	3	538	c.356G>A	c.(355-357)cGt>cAt	p.R119H	CLEC12A_ENST00000434319.2_Missense_Mutation_p.R119H|CLEC12A_ENST00000355690.4_Missense_Mutation_p.R129H|CLEC12A_ENST00000350667.4_Missense_Mutation_p.R86H	NM_138337.5|NM_201623.3	NP_612210.4|NP_963917.2	Q5QGZ9	CL12A_HUMAN	C-type lectin domain family 12, member A	119						integral to membrane|plasma membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	16						AAATTATGTCGTGAGCTATAT	0.343													14	9					0	0	1	0	0	A	10132100	G	A	10132100	3	1	47	1	0	0	0	0	1	0	0	0	3520	1145	40	1	366	1	CLEC12A	12	10132100	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		10132100	123719795	34	4360										
PXN	5829	broad.mit.edu	37	chr12	120660787	120660787	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ggtgaaggctcagctgatttCtgcttgttggggaagctttg	15	6	2	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr12:120660787C>G	ENST00000536957.1	-	4	841	c.366G>C	c.(364-366)caG>caC	p.Q122H	PXN_ENST00000424649.2_Missense_Mutation_p.Q124H|PXN_ENST00000267257.7_Missense_Mutation_p.Q124H|PXN_ENST00000458477.2_5'UTR|PXN_ENST00000228307.7_Missense_Mutation_p.Q124H|PXN_ENST00000538144.1_5'UTR			P49023	PAXI_HUMAN	paxillin	124					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCTGATTTCTGCTTGTTGG	0.522													25	28					0	0	1	0	0	G	120660787	C	G	120660787	3	3	47	1	0	0	0	0	1	0	0	0	12903	912	32	2	1439	2	PXN	12	120660787	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	110528687	120660787	13191108	35	4361										
TMEM132D	121256	broad.mit.edu	37	chr12	129822360	129822360	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cctcgtaggaggcgccatccGcactggagagaagacacaga	13	12	0	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr12:129822360G>A	ENST00000422113.2	-	4	1444	c.1118C>T	c.(1117-1119)gCg>gTg	p.A373V		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	373						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGCGCCATCCGCACTGGAGAG	0.592													89	13					0	0	1	0	0	A	129822360	G	A	129822360	3	1	47	1	0	0	0	0	1	0	0	0	16106	1087	38	1	2205	1	TMEM132D	12	129822360	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	9161573	129822360	4029535	36	4362										
FREM2	341640	broad.mit.edu	37	chr13	39262004	39262004	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tggtactggaggtggaggtgGtcttcacccagctggaggtt	17	7	2	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr13:39262004G>T	ENST00000280481.7	+	1	739	c.523G>T	c.(523-525)Gtc>Ttc	p.V175F		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	175					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGTGGAGGTGGTCTTCACCCA	0.677													5	6					0.000602214	0.000637227	1	1	0	T	39262004	G	T	39262004	3	4	47	1	0	0	0	0	1	0	0	0	6079	1261	44	5	525	5	FREM2	13	39262004	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		39262004	75907874	37	4363										
GALC	2581	broad.mit.edu	37	chr14	88411975	88411975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gtctctggttgagaacttggCgtagcgtgaagtgatgctcg	15	7	1	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr14:88411975C>T	ENST00000261304.2	-	14	1698	c.1592G>A	c.(1591-1593)cGc>cAc	p.R531H	GALC_ENST00000393568.4_Missense_Mutation_p.R508H|GALC_ENST00000393569.2_Missense_Mutation_p.R505H|GALC_ENST00000544807.2_Missense_Mutation_p.R475H	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	531			R -> C (in GLD).|R -> H (in GLD; infantile; significant reduction of activity).		carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GAGAACTTGGCGTAGCGTGAA	0.408													24	28					0	0	1	0	0	T	88411975	C	T	88411975	3	4	47	1	0	0	0	0	1	0	0	0	6240	768	27	1	481	1	GALC	14	88411975	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08		88411975	18937565	38	4364										
TUBGCP5	114791	broad.mit.edu	37	chr15	22848945	22848945	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gtttcgactccaggagttcaTtgatgaagtcatgggacaca	11	8	2	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr15:22848945T>C	ENST00000283645.4	+	10	1122	c.992T>C	c.(991-993)aTt>aCt	p.I331T	TUBGCP5_ENST00000559846.1_3'UTR|TUBGCP5_ENST00000453949.2_Missense_Mutation_p.I331T	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	331					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CAGGAGTTCATTGATGAAGTC	0.458													20	21					0	0	1	0	0	C	22848945	T	C	22848945	3	2	47	1	0	0	0	0	1	0	0	0	16830	1493	52	4	1030	4	TUBGCP5	15	22848945	Missense_Mutation	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08		22848945	79682447	39	4365										
KIAA0430	9665	broad.mit.edu	37	chr16	15729877	15729877	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cattctggagtgaagatgcaGactggaaagcaaaccctgac	11	9	1	4			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr16:15729877G>A	ENST00000396368.3	-	3	673	c.467C>T	c.(466-468)tCt>tTt	p.S156F	KIAA0430_ENST00000548025.1_Missense_Mutation_p.S156F|KIAA0430_ENST00000602337.1_Missense_Mutation_p.S156F|KIAA0430_ENST00000540441.2_Missense_Mutation_p.S156F|KIAA0430_ENST00000344181.3_5'UTR|KIAA0430_ENST00000551742.1_Missense_Mutation_p.S156F	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	155						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TGAAGATGCAGACTGGAAAGC	0.512													13	155					0	0	1	0	0	A	15729877	G	A	15729877	3	1	47	1	0	0	0	0	1	0	0	0	8218	942	33	3	4864	3	KIAA0430	16	15729877	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		15729877	74624876	40	4366										
UMOD	7369	broad.mit.edu	37	chr16	20352470	20352470	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cattgctactgggtgtggcaTagcagttggtcatgagcagt	14	7	1	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr16:20352470T>G	ENST00000396134.2	-	8	1742	c.1619A>C	c.(1618-1620)tAt>tCt	p.Y540S	UMOD_ENST00000302509.4_Missense_Mutation_p.Y507S|UMOD_ENST00000396142.2_Missense_Mutation_p.Y507S|UMOD_ENST00000570689.1_Missense_Mutation_p.Y507S|UMOD_ENST00000570331.1_5'UTR|UMOD_ENST00000396138.4_Missense_Mutation_p.Y556S|UMOD_ENST00000424589.1_Missense_Mutation_p.Y540S	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	507	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GGGTGTGGCATAGCAGTTGGT	0.542													16	25					0	0	1	0	0	G	20352470	T	G	20352470	3	3	47	1	0	0	0	0	1	0	0	0	17038	1406	49	4	422	4	UMOD	16	20352470	Missense_Mutation	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08	4622593	20352470	70002283	41	4367										
TUFM	7284	broad.mit.edu	37	chr16	28855116	28855116	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agtcagggagaacatgacagGcatgaagtgggacacaaagg	15	6	1	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr16:28855116G>T	ENST00000313511.3	-	9	1273	c.1135C>A	c.(1135-1137)Cct>Act	p.P379T		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	376						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						AACATGACAGGCATGAAGTGG	0.577													14	19					9.31168e-06	1.00877e-05	1	1	0	T	28855116	G	T	28855116	3	4	47	1	0	0	0	0	1	0	0	0	16832	1203	42	5	240	5	TUFM	16	28855116	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	8502646	28855116	61499637	42	4368										
CA10	56934	broad.mit.edu	37	chr17	50008357	50008357	+	Frame_Shift_Del	DEL	C	C	-													0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tatggtggcttaccttcctgCcccccgtgttgatgcgaaga							TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:50008357delC	ENST00000451037.2	-	3	1212	c.272delG	c.(271-273)gcfs	p.G91fs	CA10_ENST00000285273.4_Frame_Shift_Del_p.G91fs|CA10_ENST00000340813.6_Frame_Shift_Del_p.G97fs|CA10_ENST00000442502.2_Frame_Shift_Del_p.G91fs|CA10_ENST00000570565.1_Frame_Shift_Del_p.G16fs	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	91					brain development			p.G91V(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TACCTTCCTGCCCCCCGTGTT	0.493													8	406	---	---	---	---						-	50008357	C	-	50008357	7	5	47	1	0	1	0	1	0	0	0	0	2529	739	26	0	742	0	CA10	17	50008357	Frame_Shift_Del	DEL	C	TCGA-ND-A4WA-01A-12D-A28R-08		50008357	31186853	43	4369										
MRC2	9902	broad.mit.edu	37	chr17	60758178	60758178	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	caggccgacgggaatggctgCgcttccaggaggccgagtac	16	12	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:60758178C>T	ENST00000303375.5	+	17	2893	c.2491C>T	c.(2491-2493)Cgc>Tgc	p.R831C		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	831					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGAATGGCTGCGCTTCCAGGA	0.726													13	39					0	0	1	0	0	T	60758178	C	T	60758178	3	4	47	1	0	0	0	0	1	0	0	0	9806	768	27	1	2557	1	MRC2	17	60758178	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	10749821	60758178	20437032	44	4370										
TK1	7083	broad.mit.edu	37	chr17	76171208	76171209	+	Frame_Shift_Del	DEL	CG	CG	-													0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	caccgccgtcagcttcaccaCgctctcggccagcggcacca							TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:76171208_76171209delCG	ENST00000588734.1	-	6	673_674	c.435_436delCG	c.(433-438)agtgfs	p.SV145fs	TK1_ENST00000590430.1_3'UTR|TK1_ENST00000405273.1_Frame_Shift_Del_p.SV145fs|TK1_ENST00000590862.1_Frame_Shift_Del_p.SV145fs|TK1_ENST00000301634.7_Frame_Shift_Del_p.SV145fs			P04183	KITH_HUMAN	thymidine kinase 1, soluble	145					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding			endometrium(1)|large_intestine(1)|urinary_tract(2)	4			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			AGCTTCACCACGCTCTCGGCCA	0.614													21	80	---	---	---	---						-	76171209	CG	-	76171208	7	5	47	1	0	1	0	1	0	0	0	0	15991	536	19	0	276	0	TK1	17	76171208	Frame_Shift_Del	DEL	CG	TCGA-ND-A4WA-01A-12D-A28R-08	15413030	76171208	5024002	45	4371										
C1QTNF1	114897	broad.mit.edu	37	chr17	77042776	77042776	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tcaacatcactatcttgaaaGgtcagatggctgcaaagaca	8	9	4	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:77042776G>A	ENST00000339142.2	+	4	850	c.295_splice	c.e4+1	p.G99_splice	C1QTNF1_ENST00000583904.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000581774.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000580454.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000580474.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000354124.3_Splice_Site_p.G109_splice|C1QTNF1_ENST00000578229.1_Splice_Site_p.G17_splice|C1QTNF1_ENST00000392445.2_Splice_Site_p.G99_splice|C1QTNF1_ENST00000311661.4_Splice_Site_p.G17_splice|C1QTNF1_ENST00000579760.1_Splice_Site_p.G99_splice	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	99	Collagen-like.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			TATCTTGAAAGGTCAGATGGC	0.627											OREG0024791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	110					0	0	1	0	0	A	77042776	G	A	77042776	5	1	47	1	0	0	0	0	0	0	1	0	1975	1014	35	3	301	3	C1QTNF1	17	77042776	Splice_Site	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	871568	77042776	4152434	46	4372										
RNMT	8731	broad.mit.edu	37	chr18	13741541	13741541	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gacaaatttcgtgacccacaAatgtgttttgacatctgcag	8	9	1	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr18:13741541A>G	ENST00000383314.2	+	7	1065	c.825A>G	c.(823-825)caA>caG	p.Q275Q	RNMT_ENST00000589866.1_Silent_p.Q275Q|RNMT_ENST00000543302.2_Silent_p.Q275Q|RNMT_ENST00000535051.1_Silent_p.Q33Q|RNMT_ENST00000592764.1_Silent_p.Q275Q|RNMT_ENST00000262173.3_Silent_p.Q275Q			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	275					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GTGACCCACAAATGTGTTTTG	0.348													11	31					0	0	1	0	0	G	13741541	A	G	13741541	2	3	47	1	0	0	0	0	0	0	0	1	13557	11	1	4		4	RNMT	18	13741541	Silent	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08		13741541	64335707	47	4373										
C3	718	broad.mit.edu	37	chr19	6678426	6678426	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gccatgatgtactcgtcaaaGtcattggacagctgaacctt	9	10	2	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:6678426G>A	ENST00000245907.6	-	39	4763	c.4671C>T	c.(4669-4671)gaC>gaT	p.D1557D	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1557	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTCGTCAAAGTCATTGGACA	0.582													14	12					0	0	1	0	0	A	6678426	G	A	6678426	2	1	47	1	0	0	0	0	0	0	0	1	2218	1020	36	3		3	C3	19	6678426	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08		6678426	52450557	48	4374										
AKAP8L	26993	broad.mit.edu	37	chr19	15512057	15512057	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cgggagccgcccgggaaggcGcccccacctcgcatgccctg	14	19	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:15512057G>A	ENST00000397410.4	-	5	784	c.720C>T	c.(718-720)ggC>ggT	p.G240G	AKAP8L_ENST00000595136.1_5'UTR|AKAP8L_ENST00000595465.1_Silent_p.G179G	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	240						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						CCGGGAAGGCGCCCCCACCTC	0.642													60	79					0	0	1	0	0	A	15512057	G	A	15512057	2	1	47	1	0	0	0	0	0	0	0	1	455	1074	38	1		1	AKAP8L	19	15512057	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	8833631	15512057	43616926	49	4375										
ZNF585B	92285	broad.mit.edu	37	chr19	37677126	37677126	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tcccacagtgaccacatttaTaaggtttctctccagtatga	6	11	1	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:37677126T>A	ENST00000532828.2	-	5	1564	c.1313A>T	c.(1312-1314)tAt>tTt	p.Y438F	ZNF585B_ENST00000531805.1_Missense_Mutation_p.Y383F|ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000312908.5_Missense_Mutation_p.Y26F|CTC-454I21.3_ENST00000585860.2_Intron	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACCACATTTATAAGGTTTCTC	0.378													15	169					0	0	1	0	0	A	37677126	T	A	37677126	3	1	47	1	0	0	0	0	1	0	0	0	18074	1406	49	4	1000	4	ZNF585B	19	37677126	Missense_Mutation	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08	22165069	37677126	21451857	50	4376										
ARHGAP35	2909	broad.mit.edu	37	chr19	47424918	47424918	+	Frame_Shift_Del	DEL	T	T	-													0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tcgagccatcttacagcctgTttcgagaagacacatcactg							TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:47424918delT	ENST00000404338.3	+	1	2986	c.2986delT	c.(2986-2988)ttfs	p.F996fs		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	996					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										TTACAGCCTGTTTCGAGAAGA	0.483													16	41	---	---	---	---						-	47424918	T	-	47424918	7	5	47	1	0	1	0	1	0	0	0	0	6835	1725	60	0	2988	0	ARHGAP35	19	47424918	Frame_Shift_Del	DEL	T	TCGA-ND-A4WA-01A-12D-A28R-08	9747792	47424918	11704065	51	4377										
ZNF473	25888	broad.mit.edu	37	chr19	50549834	50549834	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	acgaatgcgggaaaacgttcCgtcagagctcatgcctttct	10	11	3	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:50549834C>T	ENST00000595661.1	+	6	2629	c.2134C>T	c.(2134-2136)Cgt>Tgt	p.R712C	ZNF473_ENST00000445728.3_Missense_Mutation_p.R700C|ZNF473_ENST00000270617.3_Missense_Mutation_p.R712C|ZNF473_ENST00000391821.2_Missense_Mutation_p.R712C|ZNF473_ENST00000601364.1_Intron|CTD-2126E3.3_ENST00000599410.1_RNA|CTD-2126E3.3_ENST00000599914.1_RNA			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	712					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GAAAACGTTCCGTCAGAGCTC	0.502													28	53					0	0	1	0	0	T	50549834	C	T	50549834	3	4	47	1	0	0	0	0	1	0	0	0	17987	652	23	1	2148	1	ZNF473	19	50549834	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	3124916	50549834	8579149	52	4378										
ZNF615	284370	broad.mit.edu	37	chr19	52496399	52496399	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agtctttcctgtgtgaaatcGctgatgttgtatgaggcatg	12	6	1	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:52496399G>A	ENST00000602063.1	-	6	2279	c.1930C>T	c.(1930-1932)Cga>Tga	p.R644*	ZNF615_ENST00000376716.5_Nonsense_Mutation_p.R644*|ZNF615_ENST00000594083.1_Nonsense_Mutation_p.R655*|ZNF615_ENST00000391795.3_Nonsense_Mutation_p.R649*|ZNF615_ENST00000598071.1_Nonsense_Mutation_p.R655*			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GTGTGAAATCGCTGATGTTGT	0.383													89	44					0	0	1	0	0	A	52496399	G	A	52496399	4	1	47	1	0	0	0	0	0	1	0	0	18096	1095	38	1	269	1	ZNF615	19	52496399	Nonsense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	1946565	52496399	6632584	53	4379										
KIR2DL1	3802	broad.mit.edu	37	chr19	55284834	55284834	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cacccaggtcgcctggtgaaAtcagaagagacagtcatcct	10	12	2	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:55284834A>G	ENST00000336077.6	+	3	160	c.120A>G	c.(118-120)aaA>aaG	p.K40K	KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000541392.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Silent_p.K40K|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	40					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		GCCTGGTGAAATCAGAAGAGA	0.493													6	222					0	0	1	0	0	G	55284834	A	G	55284834	2	3	47	1	0	0	0	0	0	0	0	1	8358	98	4	4		4	KIR2DL1	19	55284834	Silent	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08	2788435	55284834	3844149	54	4380										
BAGE2	85319	broad.mit.edu	37	chr21	11058340	11058340	+	RNA	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	atcgctgaaaggggtaaaggAgagaaatctctttataaaac	10	5	1	2	rs28617310	by1000genomes	TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363													4	80					0	0	1	0	0	C	11058340	A	C	11058340	1	2	47	0	1	0	0	0	0	0	0	0	1290	319	11	4		4	BAGE2	21	11058340	RNA	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08		11058340	37071555	55	4381										
BAGE2	85319	broad.mit.edu	37	chr21	11098920	11098920	+	RNA	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gcagctcagcgggagataccAgagaccctaaactggcgtga	13	11	1	3	rs78230864		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr21:11098920A>G	ENST00000470054.1	-	0	5									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gggagataccagagaccctaa	0.572													6	21					0	0	1	0	0	G	11098920	A	G	11098920	1	3	47	0	1	0	0	0	0	0	0	0	1290	203	7	4		4	BAGE2	21	11098920	RNA	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08	40580	11098920	37030975	56	4382										
RRP1	8568	broad.mit.edu	37	chr21	45217427	45217427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agctgaccaaagtgggcgccGaggaggtgaggctgggctcc	18	10	0	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr21:45217427G>A	ENST00000497547.1	+	6	664	c.547G>A	c.(547-549)Gag>Aag	p.E183K	RRP1_ENST00000471909.1_3'UTR	NM_003683.5	NP_003674.1	P56182	RRP1_HUMAN	ribosomal RNA processing 1	183					rRNA processing	nucleolus|preribosome, small subunit precursor				central_nervous_system(1)|kidney(1)|lung(4)|stomach(2)	8				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		AGTGGGCGCCGAGGAGGTGAG	0.637													35	34					0	0	1	0	0	A	45217427	G	A	45217427	3	1	47	1	0	0	0	0	1	0	0	0	13736	1059	37	1	569	1	RRP1	21	45217427	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	34118507	45217427	2912468	57	4383										
PRKX	5613	broad.mit.edu	37	chrX	3631199	3631200	+	Frame_Shift_Del	DEL	GG	GG	-													0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ggcgacagcgcctcagggctGgggcagagcgcgggcgcccc							TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:3631199_3631200delGG	ENST00000262848.5	-	1	449_450	c.95_96delCC	c.(94-96)cfs	p.P32fs		NM_005044.4	NP_005035.1	P51817	PRKX_HUMAN	protein kinase, X-linked	32							ATP binding|cAMP-dependent protein kinase activity			kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(2)	12		all_lung(23;0.000396)|Lung NSC(23;0.00123)				CCTCAGGGCTGGGGCAGAGCGC	0.757													2	4	---	---	---	---						-	3631200	GG	-	3631199	7	5	47	1	0	1	0	1	0	0	0	0	12578	1335	47	0	1012	0	PRKX	23	3631199	Frame_Shift_Del	DEL	GG	TCGA-ND-A4WA-01A-12D-A28R-08		3631199	151639361	58	4384										
NHS	4810	broad.mit.edu	37	chrX	17750472	17750472	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tgcagccagcagcagccgctAcagtgtccgctgccggctgt	13	15	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:17750472A>G	ENST00000380060.3	+	8	5119	c.4781A>G	c.(4780-4782)tAc>tGc	p.Y1594C	NHS_ENST00000398097.3_Missense_Mutation_p.Y1438C	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1594						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					AGCAGCCGCTACAGTGTCCGC	0.592													64	50					0	0	1	0	0	G	17750472	A	G	17750472	3	3	47	1	0	0	0	0	1	0	0	0	10457	391	14	4	4916	4	NHS	23	17750472	Missense_Mutation	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08	14119273	17750472	137520088	59	4385										
FAM47B	170062	broad.mit.edu	37	chrX	34962328	34962328	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cttcaacgtagacacacatcGagaaaactccgtgacttcaa	6	12	2	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:34962328G>A	ENST00000329357.5	+	1	1416	c.1380G>A	c.(1378-1380)tcG>tcA	p.S460S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	460										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GACACACATCGAGAAAACTCC	0.468													44	55					0	0	1	0	0	A	34962328	G	A	34962328	2	1	47	1	0	0	0	0	0	0	0	1	5605	1045	37	1		1	FAM47B	23	34962328	Silent	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	17211856	34962328	120308232	60	4386										
USP11	8237	broad.mit.edu	37	chrX	47101057	47101057	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ttaatcgggtgaagaagaagGagtatgtggagctgtgcgat	16	3	0	3			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:47101057G>T	ENST00000377107.2	+	9	1492	c.1138G>T	c.(1138-1140)Gag>Tag	p.E380*	USP11_ENST00000218348.3_Nonsense_Mutation_p.E423*			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	423					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						GAAGAAGAAGGAGTATGTGGA	0.567													23	23					1.9806e-07	2.22512e-07	1	1	0	T	47101057	G	T	47101057	4	4	47	1	0	0	0	0	0	1	0	0	17101	1175	41	2	1301	2	USP11	23	47101057	Nonsense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	12138729	47101057	108169503	61	4387										
SLC7A3	84889	broad.mit.edu	37	chrX	70147405	70147405	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	tgtggatccgagcaagtacaCggaacaggaggccatcctct	12	11	1	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:70147405C>T	ENST00000374299.3	-	7	1256	c.1112G>A	c.(1111-1113)cGt>cAt	p.R371H	SLC7A3_ENST00000298085.4_Missense_Mutation_p.R371H			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	371					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGCAAGTACACGGAACAGGAG	0.587													12	30					0	0	1	0	0	T	70147405	C	T	70147405	3	4	47	1	0	0	0	0	1	0	0	0	14752	536	19	1	771	1	SLC7A3	23	70147405	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	23046348	70147405	85123155	62	4388										
ATP7A	538	broad.mit.edu	37	chrX	77298882	77298882	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	agtcaagaggattcggataaAttttgtctttgctctaattt	8	5	3	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:77298882A>C	ENST00000341514.6	+	21	4228	c.4073A>C	c.(4072-4074)aAt>aCt	p.N1358T	ATP7A_ENST00000350425.4_Missense_Mutation_p.N361T|ATP7A_ENST00000343533.5_Missense_Mutation_p.N1280T	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1358					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						ATTCGGATAAATTTTGTCTTT	0.343													32	53					0	0	1	0	0	C	77298882	A	C	77298882	3	2	47	1	0	0	0	0	1	0	0	0	1188	101	4	4	4151	4	ATP7A	23	77298882	Missense_Mutation	SNP	A	TCGA-ND-A4WA-01A-12D-A28R-08	7151477	77298882	77971678	63	4389										
RPS6KA6	27330	broad.mit.edu	37	chrX	83359667	83359667	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	atctaccatcatcaaagaccTacaaaagaacgcagttttaa	4	10	3	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:83359667T>A	ENST00000262752.2	-	17	1463		c.e17-2		RPS6KA6_ENST00000543399.1_Splice_Site|RPS6KA6_ENST00000495332.1_Splice_Site	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ATCAAAGACCTACAAAAGAAC	0.294													10	13					0	0	1	0	0	A	83359667	T	A	83359667	5	1	47	1	0	0	0	0	0	0	1	0	13706	1536	53	4	807	4	RPS6KA6	23	83359667	Splice_Site	SNP	T	TCGA-ND-A4WA-01A-12D-A28R-08	6060785	83359667	71910893	64	4390										
PCDH11X	27328	broad.mit.edu	37	chrX	91090729	91090729	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ccggagatgtgccactgattCgaattgaagaggatactggt	13	7	0	4			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:91090729C>T	ENST00000373094.1	+	1	1071	c.226C>T	c.(226-228)Cga>Tga	p.R76*	PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000395337.2_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000504220.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000361724.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.R76*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	76	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GCCACTGATTCGAATTGAAGA	0.443													52	102					0	0	1	0	0	T	91090729	C	T	91090729	4	4	47	1	0	0	0	0	0	1	0	0	11554	876	31	1	228	1	PCDH11X	23	91090729	Nonsense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	7731062	91090729	64179831	65	4391										
CSTF2	1478	broad.mit.edu	37	chrX	100079128	100079128	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	gaaaattctgcatcgccagaCaaatatcccaacgctgattg	7	11	1	2			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:100079128C>A	ENST00000415585.2	+	6	606	c.584C>A	c.(583-585)aCa>aAa	p.T195K	CSTF2_ENST00000372972.2_Missense_Mutation_p.T195K|CSTF2_ENST00000486615.1_Intron			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	195	Interactions with CSTF3 and SYMPK.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						CATCGCCAGACAAATATCCCA	0.473													30	84					2.80507e-11	3.23116e-11	1	1	0	A	100079128	C	A	100079128	3	1	47	1	0	0	0	0	1	0	0	0	4009	478	17	5	606	5	CSTF2	23	100079128	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	8988399	100079128	55191432	66	4392										
TREX2	11219	broad.mit.edu	37	chrX	152710335	152710335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	cctcggctgagtgggctgcgCttggctctgcccggaagtag	16	12	1	1			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:152710335C>T	ENST00000330912.2	-	13	2104	c.554G>A	c.(553-555)aGc>aAc	p.S185N	TREX2_ENST00000370231.2_Missense_Mutation_p.S185N|TREX2_ENST00000393862.2_Missense_Mutation_p.S185N|TREX2_ENST00000370232.1_Missense_Mutation_p.S228N|TREX2_ENST00000414588.1_Missense_Mutation_p.S227N|TREX2_ENST00000338525.2_Missense_Mutation_p.S185N|TREX2_ENST00000334497.2_Missense_Mutation_p.S228N|TREX2_ENST00000402951.1_Missense_Mutation_p.S228N			Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	228					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(2)	11	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGGGCTGCGCTTGGCTCTGC	0.736								Editing and processing nucleases					12	4					0	0	1	0	0	T	152710335	C	T	152710335	3	4	47	1	0	0	0	0	1	0	0	0	16537	797	28	3	159	3	TREX2	23	152710335	Missense_Mutation	SNP	C	TCGA-ND-A4WA-01A-12D-A28R-08	52631207	152710335	2560225	67	4393										
FLNA	0	broad.mit.edu	37	chrX	153590696	153590696	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0441176470588235	3	1	0.645250040459621	5.30538922155689	0.234061289186333	1	1	0	ctcggatggggctggtgggcGtggcctgcaggcagtgggag	22	8	0	0			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:153590696G>A	ENST00000422373.1	-	18	2818	c.2570C>T	c.(2569-2571)aCg>aTg	p.T857M	FLNA_ENST00000369850.3_Missense_Mutation_p.T857M|FLNA_ENST00000344736.4_Missense_Mutation_p.T857M|FLNA_ENST00000360319.4_Missense_Mutation_p.T857M	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	857					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTGGTGGGCGTGGCCTGCAG	0.637													34	85					0	0	1	0	0	A	153590696	G	A	153590696	3	1	47	1	0	0	0	0	1	0	0	0	5965	1145	40	1	5497	1	FLNA	23	153590696	Missense_Mutation	SNP	G	TCGA-ND-A4WA-01A-12D-A28R-08	880361	153590696	1679864	68	4394										
CPSF3L	54973	broad.mit.edu	37	chr1	1248900	1248900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccctcaccatgttcttttCgtttccggcccatttccgga	7	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:1248900C>T	ENST00000540437.1	-	12	1503	c.1048G>A	c.(1048-1050)Gaa>Aaa	p.E350K	CPSF3L_ENST00000419704.1_Missense_Mutation_p.E243K|CPSF3L_ENST00000421495.2_Missense_Mutation_p.E86K|CPSF3L_ENST00000435064.1_Missense_Mutation_p.E344K|CPSF3L_ENST00000545578.1_Missense_Mutation_p.E315K|CPSF3L_ENST00000462432.1_5'UTR|CPSF3L_ENST00000450926.2_Missense_Mutation_p.E322K|CPSF3L_ENST00000411962.1_Missense_Mutation_p.E246K	NM_001256456.1	NP_001243385.1	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor 3-like	344						Golgi apparatus|nucleus	hydrolase activity			endometrium(4)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(3)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		ATGTTCTTTTCGTTTCCGGCC	0.592													25	36					0	0	1	0	0	T	1248900	C	T	1248900	3	4	48	1	0	0	0	0	1	0	0	0	3850	893	31	1	804	1	CPSF3L	1	1248900	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		1248900	248001721	1	4395										
TAS1R3	83756	broad.mit.edu	37	chr1	1268175	1268175	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccccgcgcaggaccccgtgAagccctggcaggtgagcccg	15	17	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:1268175A>C	ENST00000339381.5	+	3	1296	c.1264A>C	c.(1264-1266)Aag>Cag	p.K422Q		NM_152228.1	NP_689414.1	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	422					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GGACCCCGTGAAGCCCTGGCA	0.672													13	24					0	0	1	0	0	C	1268175	A	C	1268175	3	2	48	1	0	0	0	0	1	0	0	0	15620	247	9	4	1274	4	TAS1R3	1	1268175	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	19275	1268175	247982446	2	4396										
DVL1	1855	broad.mit.edu	37	chr1	1284285	1284285	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccgactgacccgaagtccTggtccatggacttaaagaag	12	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:1284285T>C	ENST00000378888.5	-	1	445	c.161A>G	c.(160-162)cAg>cGg	p.Q54R	DVL1_ENST00000378891.5_Missense_Mutation_p.Q54R			O14640	DVL1_HUMAN	dishevelled segment polarity protein 1	54	DIX.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCGAAGTCCTGGTCCATGGA	0.706													11	9					0	0	1	0	0	C	1284285	T	C	1284285	3	2	48	1	0	0	0	0	1	0	0	0	4861	1580	55	4	1911	4	DVL1	1	1284285	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	16110	1284285	247966336	3	4397										
TP73	7161	broad.mit.edu	37	chr1	3624317	3624317	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaccactttgaggtcactTtccagcagtccagcacggcc	8	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:3624317T>G	ENST00000378295.4	+	4	546	c.391T>G	c.(391-393)Ttc>Gtc	p.F131V	TP73_ENST00000603362.1_Missense_Mutation_p.F131V|TP73_ENST00000346387.4_Missense_Mutation_p.F131V|TP73_ENST00000378290.4_Missense_Mutation_p.F60V|TP73_ENST00000604479.1_Missense_Mutation_p.F131V|TP73_ENST00000604074.1_Missense_Mutation_p.F131V|TP73_ENST00000378280.1_Missense_Mutation_p.F82V|TP73_ENST00000378285.1_Missense_Mutation_p.F82V|TP73_ENST00000378288.4_Missense_Mutation_p.F82V|TP73_ENST00000357733.3_Missense_Mutation_p.F131V|TP73_ENST00000354437.4_Missense_Mutation_p.F131V	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	131	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		TGAGGTCACTTTCCAGCAGTC	0.662													6	71					0	0	1	0	0	G	3624317	T	G	3624317	3	3	48	1	0	0	0	0	1	0	0	0	16453	1841	64	4	444	4	TP73	1	3624317	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2340032	3624317	245626304	4	4398										
CCDC27	148870	broad.mit.edu	37	chr1	3680364	3680364	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgctgcagaaggagctccgAgagcggaggcagcagctaca	15	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:3680364A>G	ENST00000294600.2	+	8	1500	c.1416A>G	c.(1414-1416)cgA>cgG	p.R472R		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	472										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGGAGCTCCGAGAGCGGAGGC	0.567													34	43					0	0	1	0	0	G	3680364	A	G	3680364	2	3	48	1	0	0	0	0	0	0	0	1	2820	291	11	4		4	CCDC27	1	3680364	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	56047	3680364	245570257	5	4399										
CHD5	26038	broad.mit.edu	37	chr1	6190375	6190375	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaggaggaagcagaactgCtgggccccgggggctgaaaa	18	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:6190375C>A	ENST00000262450.3	-	22	3375	c.3276G>T	c.(3274-3276)caG>caT	p.Q1092H	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1092	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGCAGAACTGCTGGGCCCCGG	0.612													22	39					3.8784e-16	5.13982e-16	1	1	0	A	6190375	C	A	6190375	3	1	48	1	0	0	0	0	1	0	0	0	3350	796	28	5	2668	5	CHD5	1	6190375	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2510011	6190375	243060246	6	4400										
CHD5	26038	broad.mit.edu	37	chr1	6202593	6202593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgcagccagttgaggccctCcagctggtacgggtgcagtg	16	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:6202593C>T	ENST00000262450.3	-	14	2215	c.2116G>A	c.(2116-2118)Gag>Aag	p.E706K	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	706					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTGAGGCCCTCCAGCTGGTAC	0.627													34	61					0	0	1	0	0	T	6202593	C	T	6202593	3	4	48	1	0	0	0	0	1	0	0	0	3350	864	30	3	3860	3	CHD5	1	6202593	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12218	6202593	243048028	7	4401										
CHD5	26038	broad.mit.edu	37	chr1	6228304	6228304	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggctccacagggaaaaagTcatcgaaggcttcaagacca	11	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:6228304T>C	ENST00000262450.3	-	2	212	c.113A>G	c.(112-114)gAc>gGc	p.D38G	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	38					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGGGAAAAAGTCATCGAAGGC	0.493													55	120					0	0	1	0	0	C	6228304	T	C	6228304	3	2	48	1	0	0	0	0	1	0	0	0	3350	1667	58	4	5911	4	CHD5	1	6228304	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	25711	6228304	243022317	8	4402										
ICMT	23463	broad.mit.edu	37	chr1	6294539	6294539	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatagtgtagggaaaaatcCtacagtggctgtggggatgc	14	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:6294539C>A	ENST00000362035.3	-	3	345	c.317G>T	c.(316-318)aGg>aTg	p.R106M	ICMT_ENST00000343813.5_Intron			O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	0					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity			NS(1)|endometrium(2)	3	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GGGAAAAATCCTACAGTGGCT	0.468													3	9					0.00024832	0.000265255	1	1	0	A	6294539	C	A	6294539	3	1	48	1	0	0	0	0	1	0	0	0	7528	696	24	5		5	ICMT	1	6294539	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	66235	6294539	242956082	9	4403										
GPR153	387509	broad.mit.edu	37	chr1	6314737	6314737	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagagaccctcattccactCgaagtcggggcgctgccgcc	12	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:6314737C>T	ENST00000377893.2	-	2	488	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_207370.2	NP_997253.2	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	77						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|liver(1)|lung(7)|skin(1)	14	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		TCATTCCACTCGAAGTCGGGG	0.617													48	106					0	0	1	0	0	T	6314737	C	T	6314737	3	4	48	1	0	0	0	0	1	0	0	0	6698	893	31	1	1620	1	GPR153	1	6314737	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	20198	6314737	242935884	10	4404										
DNAJC11	55735	broad.mit.edu	37	chr1	6712926	6712926	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgaagttactcgtctgagcGcaaagttaatggaacctcct	9	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:6712926G>A	ENST00000377577.5	-	6	716	c.593C>T	c.(592-594)gCg>gTg	p.A198V	DNAJC11_ENST00000377573.5_Missense_Mutation_p.A108V|DNAJC11_ENST00000542246.1_Missense_Mutation_p.A160V|DNAJC11_ENST00000349363.6_Missense_Mutation_p.A160V|DNAJC11_ENST00000294401.7_Missense_Mutation_p.A198V	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	198					protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCGTCTGAGCGCAAAGTTAAT	0.463													32	47					0	0	1	0	0	A	6712926	G	A	6712926	3	1	48	1	0	0	0	0	1	0	0	0	4657	1087	38	1	1130	1	DNAJC11	1	6712926	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	398189	6712926	242537695	11	4405										
UTS2	10911	broad.mit.edu	37	chr1	7910941	7910941	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatctgtagaagggaagctcTttctagctcctccggagtta	10	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:7910941T>G	ENST00000377516.2	-	3	465	c.145A>C	c.(145-147)Aga>Cga	p.R49R	UTS2_ENST00000361696.5_Silent_p.R49R|UTS2_ENST00000054668.5_Silent_p.R64R			O95399	UTS2_HUMAN	urotensin 2	49					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity			kidney(1)|lung(4)|urinary_tract(1)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		AGGGAAGCTCTTTCTAGCTCC	0.438													26	53					0	0	1	0	0	G	7910941	T	G	7910941	2	3	48	1	0	0	0	0	0	0	0	1	17163	1617	56	4		4	UTS2	1	7910941	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1198015	7910941	241339680	12	4406										
H6PD	9563	broad.mit.edu	37	chr1	9324611	9324611	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtggccaacagcagcttcGacctggtgctgctgggcatg	15	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:9324611G>A	ENST00000377403.2	+	5	2361	c.2059G>A	c.(2059-2061)Gac>Aac	p.D687N	H6PD_ENST00000602477.1_Missense_Mutation_p.D698N	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	687	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CAGCAGCTTCGACCTGGTGCT	0.667													46	77					0	0	1	0	0	A	9324611	G	A	9324611	3	1	48	1	0	0	0	0	1	0	0	0	6976	1058	37	1	2073	1	H6PD	1	9324611	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1413670	9324611	239926010	13	4407										
CLSTN1	22883	broad.mit.edu	37	chr1	9811693	9811693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaggacttctccttgaacaCgggcgcgtactcattcacgt	10	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:9811693C>T	ENST00000377298.4	-	5	1279	c.487G>A	c.(487-489)Gtg>Atg	p.V163M	CLSTN1_ENST00000361311.4_Missense_Mutation_p.V153M|CLSTN1_ENST00000377288.3_Missense_Mutation_p.V163M	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	163	Cadherin 1.				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		TCCTTGAACACGGGCGCGTAC	0.507													12	26					0	0	1	0	0	T	9811693	C	T	9811693	3	4	48	1	0	0	0	0	1	0	0	0	3584	536	19	1	2518	1	CLSTN1	1	9811693	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	487082	9811693	239438928	14	4408										
KIF1B	23095	broad.mit.edu	37	chr1	10318596	10318596	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaccgtgtgtacaatgacAttggcaaggaaatgctctta	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:10318596A>C	ENST00000377086.1	+	4	431	c.229A>C	c.(229-231)Att>Ctt	p.I77L	KIF1B_ENST00000263934.6_Missense_Mutation_p.I77L|KIF1B_ENST00000377081.1_Missense_Mutation_p.I77L|KIF1B_ENST00000377083.1_Missense_Mutation_p.I77L|KIF1B_ENST00000377093.4_Missense_Mutation_p.I77L			O60333	KIF1B_HUMAN	kinesin family member 1B	77	Kinesin-motor.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GTACAATGACATTGGCAAGGA	0.373													5	74					0	0	1	0	0	C	10318596	A	C	10318596	3	2	48	1	0	0	0	0	1	0	0	0	8325	217	8	4	239	4	KIF1B	1	10318596	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	506903	10318596	238932025	15	4409										
UBIAD1	29914	broad.mit.edu	37	chr1	11346072	11346072	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcccttgagagacagtttCgaagccaggccttcaacaaa	8	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:11346072C>T	ENST00000376810.5	+	2	1227	c.901C>T	c.(901-903)Cga>Tga	p.R301*	UBIAD1_ENST00000376804.2_Intron	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	301					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GAGACAGTTTCGAAGCCAGGC	0.567													59	123					0	0	1	0	0	T	11346072	C	T	11346072	4	4	48	1	0	0	0	0	0	1	0	0	16945	876	31	1	907	1	UBIAD1	1	11346072	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1027476	11346072	237904549	16	4410										
MAD2L2	10459	broad.mit.edu	37	chr1	11735151	11735151	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagctcacctttaaaatgtcCgacgtcatggtttttagtgg	9	8	2	0	rs141637184	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:11735151C>T	ENST00000235310.3	-	10	1510	c.582G>A	c.(580-582)tcG>tcA	p.S194S	MAD2L2_ENST00000376669.5_Silent_p.S207S|MAD2L2_ENST00000376672.1_Silent_p.S207S|MAD2L2_ENST00000376667.3_Silent_p.S194S|MAD2L2_ENST00000376692.4_Silent_p.S194S			Q9UI95	MD2L2_HUMAN	MAD2 mitotic arrest deficient-like 2 (yeast)	194	HORMA.|Mediates interaction with ipaB.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding			kidney(1)|large_intestine(1)|lung(2)|ovary(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTAAAATGTCCGACGTCATGG	0.552								DNA polymerases (catalytic subunits)					11	45					0	0	1	0	0	T	11735151	C	T	11735151	2	4	48	1	0	0	0	0	0	0	0	1	9195	639	23	1		1	MAD2L2	1	11735151	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	389079	11735151	237515470	17	4411										
CLCN6	1185	broad.mit.edu	37	chr1	11888619	11888619	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggagccacattcaactgTctgaacaagaggcttgcaaa	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:11888619T>C	ENST00000346436.6	+	12	1111	c.1059T>C	c.(1057-1059)tgT>tgC	p.C353C	CLCN6_ENST00000376496.3_Silent_p.C353C|CLCN6_ENST00000312413.6_Intron|CLCN6_ENST00000376487.3_Silent_p.C331C|CLCN6_ENST00000376492.3_Intron	NM_001286.3	NP_001277.1	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	353					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CATTCAACTGTCTGAACAAGA	0.542													101	189					0	0	1	0	0	C	11888619	T	C	11888619	2	2	48	1	0	0	0	0	0	0	0	1	3490	1673	58	4		4	CLCN6	1	11888619	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	153468	11888619	237362002	18	4412										
VPS13D	55187	broad.mit.edu	37	chr1	12337274	12337274	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatgtctcaatgggtagcaCgtttgacatgaatggttctc	10	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:12337274C>T	ENST00000358136.3	+	19	3759	c.3629C>T	c.(3628-3630)aCg>aTg	p.T1210M	VPS13D_ENST00000356315.4_Missense_Mutation_p.T1210M	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1210					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ATGGGTAGCACGTTTGACATG	0.413													23	110					0	0	1	0	0	T	12337274	C	T	12337274	3	4	48	1	0	0	0	0	1	0	0	0	17251	536	19	1	3699	1	VPS13D	1	12337274	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	448655	12337274	236913347	19	4413										
VPS13D	55187	broad.mit.edu	37	chr1	12414216	12414216	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaatgccaattaatgggaCgctgaaacctggcaaggagg	14	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:12414216C>T	ENST00000358136.3	+	47	9747	c.9617C>T	c.(9616-9618)aCg>aTg	p.T3206M	VPS13D_ENST00000356315.4_Missense_Mutation_p.T3181M	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3205					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ATTAATGGGACGCTGAAACCT	0.438													32	40					0	0	1	0	0	T	12414216	C	T	12414216	3	4	48	1	0	0	0	0	1	0	0	0	17251	536	19	1	9799	1	VPS13D	1	12414216	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	76942	12414216	236836405	20	4414										
PRAMEF2	65122	broad.mit.edu	37	chr1	12921510	12921510	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagatcttcaccccacttcGggctgagctgatgtgtacac	11	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:12921510G>A	ENST00000240189.2	+	4	1388	c.1301G>A	c.(1300-1302)cGg>cAg	p.R434Q		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	434								p.R434L(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCCACTTCGGGCTGAGCTG	0.552													72	61					0	0	1	0	0	A	12921510	G	A	12921510	3	1	48	1	0	0	0	0	1	0	0	0	12483	1116	39	1	1311	1	PRAMEF2	1	12921510	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	507294	12921510	236329111	21	4415										
PRDM2	7799	broad.mit.edu	37	chr1	14106775	14106775	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccactggatttatccagcGgtgtcaaacagaaggctgag	12	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:14106775G>A	ENST00000235372.7	+	8	3341	c.2485G>A	c.(2485-2487)Ggt>Agt	p.G829S	PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000343137.4_Missense_Mutation_p.G628S|PRDM2_ENST00000413440.1_Missense_Mutation_p.G628S|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000311066.5_Missense_Mutation_p.G829S	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	829						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TTTATCCAGCGGTGTCAAACA	0.463													21	60					0	0	1	0	0	A	14106775	G	A	14106775	3	1	48	1	0	0	0	0	1	0	0	0	12509	1116	39	1	2511	1	PRDM2	1	14106775	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1185265	14106775	235143846	22	4416										
CELA2A	63036	broad.mit.edu	37	chr1	15789927	15789927	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaaccccgtctccctcaccGacaagatccagctggcctgc	7	19	2	1	rs140151330	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:15789927G>A	ENST00000359621.4	+	5	428	c.403G>A	c.(403-405)Gac>Aac	p.D135N		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	135	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CTCCCTCACCGACAAGATCCA	0.602													38	94					0	0	1	0	0	A	15789927	G	A	15789927	3	1	48	1	0	0	0	0	1	0	0	0	3233	1058	37	1	421	1	CELA2A	1	15789927	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1683152	15789927	233460694	23	4417										
RSC1A1	6248	broad.mit.edu	37	chr1	15987116	15987116	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagaaacatttatggaaatCgatacagctcaacagtccct	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:15987116C>T	ENST00000345034.1	+	1	753	c.753C>T	c.(751-753)atC>atT	p.I251I	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	251					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTATGGAAATCGATACAGCTC	0.418													18	54					0	0	1	0	0	T	15987116	C	T	15987116	2	4	48	1	0	0	0	0	0	0	0	1	13749	874	31	1		1	RSC1A1	1	15987116	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	197189	15987116	233263505	24	4418										
RSC1A1	6248	broad.mit.edu	37	chr1	15987291	15987291	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attccatttccactcaggatTtacagcccccagaaactaat	4	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:15987291T>G	ENST00000345034.1	+	1	928	c.928T>G	c.(928-930)Tta>Gta	p.L310V	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	310					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACTCAGGATTTACAGCCCCC	0.393													31	30					0	0	1	0	0	G	15987291	T	G	15987291	3	3	48	1	0	0	0	0	1	0	0	0	13749	1838	64	4	930	4	RSC1A1	1	15987291	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	175	15987291	233263330	25	4419										
NBPF1	55672	broad.mit.edu	37	chr1	16892261	16892261	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatccagtgagtcctgcaaGacttcaggctctactgcctc	8	14	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:16892261G>T	ENST00000430580.2	-	27	3818	c.2931C>A	c.(2929-2931)gtC>gtA	p.V977V		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	977	NBPF 6.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGTCCTGCAAGACTTCAGGCT	0.498													8	740					7.48243e-07	8.49459e-07	1	1	0	T	16892261	G	T	16892261	2	4	48	1	0	0	0	0	0	0	0	1	10239	929	33	2		2	NBPF1	1	16892261	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	904970	16892261	232358360	26	4420										
NBPF1	55672	broad.mit.edu	37	chr1	16918352	16918352	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagatcttactgtatttcttCtgtcggttggccaggaagcc	10	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:16918352C>A	ENST00000430580.2	-	7	1052	c.165G>T	c.(163-165)caG>caT	p.Q55H		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	55						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGTATTTCTTCTGTCGGTTGG	0.433													27	642					3.93418e-24	5.51393e-24	1	1	0	A	16918352	C	A	16918352	3	1	48	1	0	0	0	0	1	0	0	0	10239	912	32	2	3351	2	NBPF1	1	16918352	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	26091	16918352	232332269	27	4421										
PADI1	29943	broad.mit.edu	37	chr1	17567222	17567222	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccagctcttcttcctgaaAaacttctacgcggaagcctt	6	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:17567222A>C	ENST00000375471.4	+	15	1817	c.1725A>C	c.(1723-1725)aaA>aaC	p.K575N	PADI1_ENST00000413717.2_Intron|PADI1_ENST00000537499.1_Missense_Mutation_p.K132N|PADI1_ENST00000460293.1_3'UTR|PADI1_ENST00000536552.1_Missense_Mutation_p.K46N	NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	575					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	TCTTCCTGAAAAACTTCTACG	0.577													52	75					0	0	1	0	0	C	17567222	A	C	17567222	3	2	48	1	0	0	0	0	1	0	0	0	11423	11	1	4	1783	4	PADI1	1	17567222	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	648870	17567222	231683399	28	4422										
RCC2	55920	broad.mit.edu	37	chr1	17740182	17740182	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catagccaccaaagccccagGagaagactcgcttctgggag	11	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:17740182G>T	ENST00000375436.4	-	9	1245	c.1058C>A	c.(1057-1059)tCc>tAc	p.S353Y	AC004824.1_ENST00000583469.1_RNA|RCC2_ENST00000375433.3_Missense_Mutation_p.S353Y	NM_018715.3	NP_061185.1	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	353					cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle				breast(2)|endometrium(1)|kidney(3)|large_intestine(7)|lung(4)	17		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		AAAGCCCCAGGAGAAGACTCG	0.577													10	121					4.68919e-08	5.48405e-08	1	1	0	T	17740182	G	T	17740182	3	4	48	1	0	0	0	0	1	0	0	0	13225	1174	41	2	530	2	RCC2	1	17740182	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	172960	17740182	231510439	29	4423										
ARHGEF10L	55160	broad.mit.edu	37	chr1	17961057	17961057	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccaggcctgccaaccacaGgtacgtggttcagggggctc	13	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:17961057G>T	ENST00000361221.3	+	17	1904	c.1745_splice	c.e17+1	p.R582_splice	ARHGEF10L_ENST00000375420.3_Splice_Site_p.R340_splice|ARHGEF10L_ENST00000469726.1_Intron|ARHGEF10L_ENST00000375415.1_Splice_Site_p.R543_splice|ARHGEF10L_ENST00000434513.1_Intron|ARHGEF10L_ENST00000452522.1_Splice_Site_p.R543_splice|ARHGEF10L_ENST00000167825.4_Intron|ARHGEF10L_ENST00000375408.3_Intron	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	582					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GCCAACCACAGGTACGTGGTT	0.622													9	100					0.00448238	0.00465112	1	1	0	T	17961057	G	T	17961057	5	4	48	1	0	0	0	0	0	0	1	0	892	1014	35	5	1807	5	ARHGEF10L	1	17961057	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	220875	17961057	231289564	30	4424										
UBR4	23352	broad.mit.edu	37	chr1	19470546	19470546	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcctgggccttaggactcGaattagagcttgtttacaag	11	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:19470546G>A	ENST00000375267.2	-	55	8110	c.8107C>T	c.(8107-8109)Cga>Tga	p.R2703*	UBR4_ENST00000375226.2_Nonsense_Mutation_p.R2714*|UBR4_ENST00000375217.2_Nonsense_Mutation_p.R2731*|UBR4_ENST00000375254.3_Nonsense_Mutation_p.R2703*			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2703					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CTTAGGACTCGAATTAGAGCT	0.438													37	69					0	0	1	0	0	A	19470546	G	A	19470546	4	1	48	1	0	0	0	0	0	1	0	0	16964	1066	37	1	7652	1	UBR4	1	19470546	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1509489	19470546	229780075	31	4425										
UBR4	23352	broad.mit.edu	37	chr1	19477235	19477235	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctccttagtcttgccataAatttttacagcatctatcat	4	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:19477235A>C	ENST00000375267.2	-	49	7269	c.7266T>G	c.(7264-7266)atT>atG	p.I2422M	UBR4_ENST00000375226.2_Missense_Mutation_p.I2422M|UBR4_ENST00000375217.2_Missense_Mutation_p.I2422M|UBR4_ENST00000375254.3_Missense_Mutation_p.I2422M			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2422					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding	p.I2422I(1)		breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCTTGCCATAAATTTTTACAG	0.488													115	210					0	0	1	0	0	C	19477235	A	C	19477235	3	2	48	1	0	0	0	0	1	0	0	0	16964	10	1	4	8517	4	UBR4	1	19477235	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6689	19477235	229773386	32	4426										
AKR7L	246181	broad.mit.edu	37	chr1	19593790	19593790	+	RNA	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggcagcctgagccacaatGagcttagatgaagtagttgg	14	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:19593790G>T	ENST00000420396.2	-	0	802				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						GAGCCACAATGAGCTTAGATG	0.507													16	69					9.16793e-09	1.08598e-08	1	1	0	T	19593790	G	T	19593790	1	4	48	0	1	0	0	0	0	0	0	0	474	1305	45	2		2	AKR7L	1	19593790	RNA	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	116555	19593790	229656831	33	4427										
EIF4G3	8672	broad.mit.edu	37	chr1	21212755	21212755	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttttggcttggcttccagGcattttctgcctttttcagg	10	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:21212755G>A	ENST00000602326.1	-	17	2796	c.2213C>T	c.(2212-2214)gCc>gTc	p.A738V	EIF4G3_ENST00000374935.3_Missense_Mutation_p.A452V|EIF4G3_ENST00000400422.1_Missense_Mutation_p.A732V|EIF4G3_ENST00000374937.3_Missense_Mutation_p.A738V|EIF4G3_ENST00000536266.1_Missense_Mutation_p.A336V|EIF4G3_ENST00000264211.8_Missense_Mutation_p.A732V|EIF4G3_ENST00000537738.1_Missense_Mutation_p.A222V	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	732	eIF3/EIF4A-binding (By similarity).				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGGCTTCCAGGCATTTTCTGC	0.418													15	152					0	0	1	0	0	A	21212755	G	A	21212755	3	1	48	1	0	0	0	0	1	0	0	0	5066	1203	42	3	2638	3	EIF4G3	1	21212755	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1618965	21212755	228037866	34	4428										
EPHA8	2046	broad.mit.edu	37	chr1	22919928	22919928	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcatcctggagtatgagatCaagtactacgagaaggtacc	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:22919928C>A	ENST00000166244.3	+	6	1497	c.1425C>A	c.(1423-1425)atC>atA	p.I475I		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	475	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGTATGAGATCAAGTACTACG	0.652													12	5					0.00010058	0.000108553	1	1	0	A	22919928	C	A	22919928	2	1	48	1	0	0	0	0	0	0	0	1	5201	816	29	2		2	EPHA8	1	22919928	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1707173	22919928	226330693	35	4429										
EPHB2	2048	broad.mit.edu	37	chr1	23219473	23219473	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatctatgtcttccaggtgCgggcacgcaccgtggcaggt	13	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:23219473C>T	ENST00000400191.3	+	7	1543	c.1525C>T	c.(1525-1527)Cgg>Tgg	p.R509W	EPHB2_ENST00000374632.3_Missense_Mutation_p.R509W|EPHB2_ENST00000374627.1_Missense_Mutation_p.R504W|EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374630.3_Missense_Mutation_p.R509W	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	509	Fibronectin type-III 2.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CTTCCAGGTGCGGGCACGCAC	0.607													37	69					0	0	1	0	0	T	23219473	C	T	23219473	3	4	48	1	0	0	0	0	1	0	0	0	5203	759	27	1	1551	1	EPHB2	1	23219473	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	299545	23219473	226031148	36	4430										
KDM1A	23028	broad.mit.edu	37	chr1	23408000	23408000	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcatggaaaacataagtgaCgatgtgattgttggccgatg	12	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:23408000C>T	ENST00000400181.4	+	19	2336	c.2232C>T	c.(2230-2232)gaC>gaT	p.D744D	KDM1A_ENST00000356634.3_Silent_p.D720D|KDM1A_ENST00000542151.1_Silent_p.D744D|RP1-184J9.2_ENST00000427154.1_RNA	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	720	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						ACATAAGTGACGATGTGATTG	0.483													31	43					0	0	1	0	0	T	23408000	C	T	23408000	2	4	48	1	0	0	0	0	0	0	0	1	8165	535	19	1		1	KDM1A	1	23408000	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	188527	23408000	225842621	37	4431										
TCEA3	6920	broad.mit.edu	37	chr1	23743807	23743807	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttctggcttccagtctgaAcactcaagccctttttcctt	6	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:23743807A>T	ENST00000450454.2	-	4	421	c.315T>A	c.(313-315)tgT>tgA	p.C105*	TCEA3_ENST00000461794.1_Nonsense_Mutation_p.C68*|TCEA3_ENST00000374601.3_Nonsense_Mutation_p.C105*	NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	105					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TCCAGTCTGAACACTCAAGcc	0.473													8	70					0	0	1	0	0	T	23743807	A	T	23743807	4	4	48	1	0	0	0	0	0	1	0	0	15728	41	2	4	763	4	TCEA3	1	23743807	Nonsense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	335807	23743807	225506814	38	4432										
TCEB3	6924	broad.mit.edu	37	chr1	24077751	24077751	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggccacagcaatgcctttcAggacagactcggggccagcc	12	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:24077751A>C	ENST00000418390.2	+	4	1005	c.734A>C	c.(733-735)cAg>cCg	p.Q245P		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	245					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AATGCCTTTCAGGACAGACTC	0.542											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	90					0	0	1	0	0	C	24077751	A	C	24077751	3	2	48	1	0	0	0	0	1	0	0	0	15740	188	7	4	748	4	TCEB3	1	24077751	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	333944	24077751	225172870	39	4433										
CNR2	1269	broad.mit.edu	37	chr1	24201065	24201065	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatctctggaatctggccacGgagtgattttcccatcagcc	10	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:24201065G>A	ENST00000536471.1	-	3	1301	c.1043C>T	c.(1042-1044)cCg>cTg	p.P348L	CNR2_ENST00000374472.4_Missense_Mutation_p.P348L			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	348					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	ATCTGGCCACGGAGTGATTTT	0.507													40	76					0	0	1	0	0	A	24201065	G	A	24201065	3	1	48	1	0	0	0	0	1	0	0	0	3655	1116	39	1	43	1	CNR2	1	24201065	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	123314	24201065	225049556	40	4434										
MYOM3	127294	broad.mit.edu	37	chr1	24388592	24388592	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgatcaccactctccagacGtttgtctctgaatgtgaggg	10	12	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:24388592G>A	ENST00000330966.7	-	33	3949	c.3787C>T	c.(3787-3789)Cgt>Tgt	p.R1263C	MYOM3_ENST00000374434.3_Missense_Mutation_p.R1260C|MYOM3_ENST00000338909.5_Missense_Mutation_p.R153C|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1260										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTCTCCAGACGTTTGTCTCTG	0.512													35	81					0	0	1	0	0	A	24388592	G	A	24388592	3	1	48	1	0	0	0	0	1	0	0	0	10140	1145	40	1	555	1	MYOM3	1	24388592	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	187527	24388592	224862029	41	4435										
RHD	6007	broad.mit.edu	37	chr1	25599130	25599130	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattctcctcttctatttttTtacccactatgacgcttcct	2	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:25599130T>G	ENST00000328664.4	+	1	247	c.92T>G	c.(91-93)tTt>tGt	p.F31C	RHD_ENST00000417538.2_Missense_Mutation_p.F31C|RHD_ENST00000454452.2_Missense_Mutation_p.F31C|RHD_ENST00000568195.1_Missense_Mutation_p.F31C|RHD_ENST00000357542.4_Missense_Mutation_p.F31C|RHD_ENST00000342055.5_Missense_Mutation_p.F31C|RHD_ENST00000423253.1_3'UTR|RHD_ENST00000423810.2_Missense_Mutation_p.F31C	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	31						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTCTATTTTTTTACCCACTAT	0.527													4	85					0	0	1	0	0	G	25599130	T	G	25599130	3	3	48	1	0	0	0	0	1	0	0	0	13376	1841	64	4	94	4	RHD	1	25599130	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1210538	25599130	223651491	42	4436										
TMEM57	55219	broad.mit.edu	37	chr1	25783143	25783143	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctggattgtcttctttctaGtattgggtaccctgtggtaa	11	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:25783143G>A	ENST00000374343.4	+	5	652		c.e5-1		TMEM57_ENST00000399766.3_Intron|TMEM57_ENST00000470035.1_Intron|TMEM57_ENST00000399763.3_Intron	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57							axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part				breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCTTTCTAGTATTGGGTAC	0.363													11	35					0	0	1	0	0	A	25783143	G	A	25783143	5	1	48	1	0	0	0	0	0	0	1	0	16243	1043	36	3	491	3	TMEM57	1	25783143	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	184013	25783143	223467478	43	4437										
MAN1C1	57134	broad.mit.edu	37	chr1	26085155	26085155	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatccctgcacttggaattCttacacctcactgaactctc	6	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:26085155C>A	ENST00000374332.4	+	6	1332	c.1002C>A	c.(1000-1002)ttC>ttA	p.F334L	MAN1C1_ENST00000473891.1_3'UTR|MAN1C1_ENST00000374329.1_Missense_Mutation_p.F105L|MAN1C1_ENST00000263979.3_Missense_Mutation_p.F154L	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	334					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		ACTTGGAATTCTTACACCTCA	0.587													25	58					5.45024e-15	7.15042e-15	1	1	0	A	26085155	C	A	26085155	3	1	48	1	0	0	0	0	1	0	0	0	9262	912	32	2	1024	2	MAN1C1	1	26085155	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	302012	26085155	223165466	44	4438										
UBXN11	91544	broad.mit.edu	37	chr1	26612003	26612003	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctggagctctgagggaaaGaagccatccaatatgtctcg	12	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:26612003G>A	ENST00000314675.7	-	6	523	c.444C>T	c.(442-444)ttC>ttT	p.F148F	UBXN11_ENST00000374217.2_Silent_p.F235F|UBXN11_ENST00000374221.3_Silent_p.F268F|UBXN11_ENST00000374222.1_Silent_p.F268F|UBXN11_ENST00000535108.1_Silent_p.F110F|UBXN11_ENST00000436301.2_Silent_p.F193F|UBXN11_ENST00000374223.1_Silent_p.F25F|UBXN11_ENST00000357089.4_Silent_p.F235F	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	268						cytoplasm|cytoskeleton				endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						CTGAGGGAAAGAAGCCATCCA	0.587											OREG0013265	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	18					0	0	1	0	0	A	26612003	G	A	26612003	2	1	48	1	0	0	0	0	0	0	0	1	16972	933	33	3		3	UBXN11	1	26612003	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	526848	26612003	222638618	45	4439										
ARID1A	8289	broad.mit.edu	37	chr1	27099430	27099430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacctctgacatgatggggCgcatgtcctatgagccaaat	10	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:27099430C>T	ENST00000324856.7	+	14	4038	c.3667C>T	c.(3667-3669)Cgc>Tgc	p.R1223C	ARID1A_ENST00000457599.2_Missense_Mutation_p.R1223C|ARID1A_ENST00000374152.2_Missense_Mutation_p.R840C	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1223					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.M1220fs*9(1)|p.M1220fs*2(1)|p.R1223C(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CATGATGGGGCGCATGTCCTA	0.473			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								22	29					0	0	1	0	0	T	27099430	C	T	27099430	3	4	48	1	0	0	0	0	1	0	0	0	910	768	27	1	3721	1	ARID1A	1	27099430	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	487427	27099430	222151191	46	4440										
ARID1A	8289	broad.mit.edu	37	chr1	27100374	27100374	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccagcagactacaatgtaTcaacagcaacagcaggtgag	10	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:27100374T>G	ENST00000324856.7	+	17	4457	c.4086T>G	c.(4084-4086)taT>taG	p.Y1362*	ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Y1362*|ARID1A_ENST00000540690.1_De_novo_Start_OutOfFrame|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Y979*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1362	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTACAATGTATCAACAGCAAC	0.488			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								76	128					0	0	1	0	0	G	27100374	T	G	27100374	4	3	48	1	0	0	0	0	0	1	0	0	910	1442	50	4	4152	4	ARID1A	1	27100374	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	944	27100374	222150247	47	4441										
MAP3K6	9064	broad.mit.edu	37	chr1	27683511	27683511	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctcctacccggtcctagcAcacccagggctgcccgcaca	8	21	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:27683511A>G	ENST00000374040.3	-	23	3589	c.3329T>C	c.(3328-3330)gTg>gCg	p.V1110A	MAP3K6_ENST00000493901.1_Missense_Mutation_p.V1118A|MAP3K6_ENST00000357582.2_Missense_Mutation_p.V1118A			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	1118					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGGTCCTAGCACACCCAGGGC	0.662													14	29					0	0	1	0	0	G	27683511	A	G	27683511	3	3	48	1	0	0	0	0	1	0	0	0	9303	159	6	4	537	4	MAP3K6	1	27683511	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	583137	27683511	221567110	48	4442										
FGR	2268	broad.mit.edu	37	chr1	27941062	27941062	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtcgcggtgaatgtagttCatgcgttccatgtaggccat	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:27941062C>A	ENST00000374005.3	-	11	1416	c.1128G>T	c.(1126-1128)atG>atT	p.M376I	FGR_ENST00000545953.1_Missense_Mutation_p.M310I|FGR_ENST00000399173.1_Missense_Mutation_p.M376I|FGR_ENST00000374004.1_Missense_Mutation_p.M376I	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	376	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GAATGTAGTTCATGCGTTCCA	0.592													11	17					0.00829132	0.00855608	1	1	0	A	27941062	C	A	27941062	3	1	48	1	0	0	0	0	1	0	0	0	5906	826	29	2	473	2	FGR	1	27941062	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	257551	27941062	221309559	49	4443										
PPP1R8	5511	broad.mit.edu	37	chr1	28167551	28167551	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcactttcttgggtcacattCggttggaacctcacaagcct	9	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:28167551C>T	ENST00000311772.5	+	4	356	c.298C>T	c.(298-300)Cgg>Tgg	p.R100W	PPP1R8_ENST00000236412.7_Intron|PPP1R8_ENST00000373931.4_5'UTR	NM_014110.4	NP_054829.2	Q12972	PP1R8_HUMAN	protein phosphatase 1, regulatory subunit 8	100	FHA.|Interaction with CDC5L, SF3B1 and MELK.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding			breast(2)|cervix(1)|endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		GGGTCACATTCGGTTGGAACC	0.478													38	78					0	0	1	0	0	T	28167551	C	T	28167551	3	4	48	1	0	0	0	0	1	0	0	0	12425	875	31	1	312	1	PPP1R8	1	28167551	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	226489	28167551	221083070	50	4444										
TRNAU1AP	54952	broad.mit.edu	37	chr1	28897731	28897731	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagtcagatgtacagttatAgctacaaccagtattatcag	7	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:28897731A>G	ENST00000373830.3	+	7	600	c.574A>G	c.(574-576)Agc>Ggc	p.S192G		NM_017846.4	NP_060316.1	Q9NX07	TSAP1_HUMAN	tRNA selenocysteine 1 associated protein 1	192	Tyr-rich.				selenocysteine incorporation	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(2)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	8						GTACAGTTATAGCTACAACCA	0.428													28	37					0	0	1	0	0	G	28897731	A	G	28897731	3	3	48	1	0	0	0	0	1	0	0	0	16632	420	15	4	600	4	TRNAU1AP	1	28897731	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	730180	28897731	220352890	51	4445										
MECR	51102	broad.mit.edu	37	chr1	29533290	29533290	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctacctggctgcagttgctcGaagtccatcaacatcctgta	8	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:29533290G>A	ENST00000373791.3	-	4	678	c.306C>T	c.(304-306)ttC>ttT	p.F102F	MECR_ENST00000489248.1_5'UTR|MECR_ENST00000263702.6_Silent_p.F178F	NM_001024732.1|NM_016011.2	NP_001019903.1|NP_057095.2	Q9BV79	MECR_HUMAN	mitochondrial trans-2-enoyl-CoA reductase	178					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)	11		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		GCAGTTGCTCGAAGTCCATCA	0.592													24	52					0	0	1	0	0	A	29533290	G	A	29533290	2	1	48	1	0	0	0	0	0	0	0	1	9473	1049	37	1		1	MECR	1	29533290	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	635559	29533290	219717331	52	4446										
MATN1	4146	broad.mit.edu	37	chr1	31194488	31194488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggccccacgtccagcgactCgatgacctgggacaggaata	13	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:31194488C>T	ENST00000373765.4	-	2	240	c.205G>A	c.(205-207)Gag>Aag	p.E69K	MATN1-AS1_ENST00000414763.1_RNA|MATN1-AS1_ENST00000454613.1_RNA|MATN1-AS1_ENST00000414532.2_RNA	NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	69	VWFA 1.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAGCGACTCGATGACCTGG	0.602													47	102					0	0	1	0	0	T	31194488	C	T	31194488	3	4	48	1	0	0	0	0	1	0	0	0	9382	893	31	1	1313	1	MATN1	1	31194488	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1661198	31194488	218056133	53	4447										
LAPTM5	7805	broad.mit.edu	37	chr1	31212746	31212746	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaggagatagtccatgatTtgcagggacaggaagggcag	15	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:31212746T>C	ENST00000294507.3	-	4	371	c.297A>G	c.(295-297)caA>caG	p.Q99Q		NM_006762.2	NP_006753.1	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	99					transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		AGTCCATGATTTGCAGGGACA	0.612													19	36					0	0	1	0	0	C	31212746	T	C	31212746	2	2	48	1	0	0	0	0	0	0	0	1	8664	1838	64	4		4	LAPTM5	1	31212746	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	18258	31212746	218037875	54	4448										
ZCCHC17	51538	broad.mit.edu	37	chr1	31810034	31810034	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcccaggtctggtccatcGaactcatatgtcatcctgtc	9	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:31810034G>A	ENST00000373714.1	+	4	398	c.137G>A	c.(136-138)cGa>cAa	p.R46Q	RP11-266K22.2_ENST00000430143.1_RNA|ZCCHC17_ENST00000479629.1_3'UTR|ZCCHC17_ENST00000422613.2_Missense_Mutation_p.R22Q|ZCCHC17_ENST00000344147.5_Missense_Mutation_p.R46Q|ZCCHC17_ENST00000546109.1_Missense_Mutation_p.R38Q			Q9NP64	NO40_HUMAN	zinc finger, CCHC domain containing 17	46	S1 motif.					nucleolus	RNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)		CTGGTCCATCGAACTCATATG	0.438													33	51					0	0	1	0	0	A	31810034	G	A	31810034	3	1	48	1	0	0	0	0	1	0	0	0	17643	1058	37	1	147	1	ZCCHC17	1	31810034	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	597288	31810034	217440587	55	4449										
TMEM39B	55116	broad.mit.edu	37	chr1	32566248	32566248	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgtgatgtcattgcaagaGaaagctattttcagtatttc	8	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:32566248G>T	ENST00000427288.1	+	9	1456	c.976G>T	c.(976-978)Gaa>Taa	p.E326*	TMEM39B_ENST00000373634.4_Intron|TMEM39B_ENST00000336294.5_Intron|TMEM39B_ENST00000487305.1_Intron			Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	0						integral to membrane				endometrium(2)|kidney(1)|lung(5)|ovary(1)|prostate(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CATTGCAAGAGAAAGCTATTT	0.512													9	15					0.0477658	0.0484551	1	1	0	T	32566248	G	T	32566248	4	4	48	1	0	0	0	0	0	1	0	0	16221	957	33	2		2	TMEM39B	1	32566248	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	756214	32566248	216684373	56	4450										
ZBTB8A	653121	broad.mit.edu	37	chr1	33060820	33060820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatctaagtagccattttcGaacagtatgtatgatttttt	6	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:33060820G>A	ENST00000373510.4	+	4	1218	c.989G>A	c.(988-990)cGa>cAa	p.R330Q	RP1-27O5.3_ENST00000480336.1_3'UTR|ZBTB8A_ENST00000316459.4_Missense_Mutation_p.R330Q	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						AGCCATTTTCGAACAGTATGT	0.383													56	33					0	0	1	0	0	A	33060820	G	A	33060820	3	1	48	1	0	0	0	0	1	0	0	0	17614	1058	37	1	995	1	ZBTB8A	1	33060820	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	494572	33060820	216189801	57	4451										
KIAA1522	57648	broad.mit.edu	37	chr1	33237828	33237828	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggccaccccaggccccaaaGaagtcacctaaggctccccc	8	20	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:33237828G>T	ENST00000401073.2	+	6	3118	c.3048G>T	c.(3046-3048)aaG>aaT	p.K1016N	KIAA1522_ENST00000373480.1_Missense_Mutation_p.K957N|KIAA1522_ENST00000373481.3_Missense_Mutation_p.K968N|KIAA1522_ENST00000294521.3_Intron	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	957										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGCCCCAAAGAAGTCACCTA	0.672													28	53					1.42536e-11	1.77514e-11	1	1	0	T	33237828	G	T	33237828	3	4	48	1	0	0	0	0	1	0	0	0	8279	933	33	2	3070	2	KIAA1522	1	33237828	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	177008	33237828	216012793	58	4452										
PHC2	1912	broad.mit.edu	37	chr1	33796962	33796962	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactcacctctttgcacaagCcatggaacagaagcgcttgg	9	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:33796962C>T	ENST00000257118.5	-	11	2043	c.1990G>A	c.(1990-1992)Gct>Act	p.A664T	PHC2_ENST00000373418.3_Missense_Mutation_p.A129T|PHC2_ENST00000485928.1_5'UTR|PHC2_ENST00000431992.1_Missense_Mutation_p.A635T|PHC2_ENST00000419414.2_Missense_Mutation_p.A665T|PHC2_ENST00000373416.1_Missense_Mutation_p.A129T|PHC2_ENST00000373422.3_Missense_Mutation_p.A270T	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	664					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TTTGCACAAGCCATGGAACAG	0.547													33	85					0	0	1	0	0	T	33796962	C	T	33796962	3	4	48	1	0	0	0	0	1	0	0	0	11864	739	26	3	602	3	PHC2	1	33796962	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	559134	33796962	215453659	59	4453										
CSMD2	114784	broad.mit.edu	37	chr1	34006219	34006219	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacccctccaggcaggcataAgtcacacttgagccccacat	7	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:34006219A>C	ENST00000373381.4	-	60	9713	c.9537T>G	c.(9535-9537)acT>acG	p.T3179T		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3155	Sushi 25.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCAGGCATAAGTCACACTTG	0.597													38	65					0	0	1	0	0	C	34006219	A	C	34006219	2	2	48	1	0	0	0	0	0	0	0	1	3970	59	3	4		4	CSMD2	1	34006219	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	209257	34006219	215244402	60	4454										
CSMD2	114784	broad.mit.edu	37	chr1	34166245	34166245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctaaaaactcccagcaaaCgggcggagttgttgttgcca	12	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:34166245C>T	ENST00000373381.4	-	23	3781	c.3605G>A	c.(3604-3606)cGt>cAt	p.R1202H	CSMD2_ENST00000373380.1_Missense_Mutation_p.R75H|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1162	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TCCCAGCAAACGGGCGGAGTT	0.498													26	51					0	0	1	0	0	T	34166245	C	T	34166245	3	4	48	1	0	0	0	0	1	0	0	0	3970	536	19	1	7166	1	CSMD2	1	34166245	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	160026	34166245	215084376	61	4455										
GJA4	2701	broad.mit.edu	37	chr1	35259970	35259970	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgacgagcaatcagatttCgagtgtaacacggcccagcc	12	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:35259970C>T	ENST00000342280.4	+	2	244	c.156C>T	c.(154-156)ttC>ttT	p.F52F		NM_002060.2	NP_002051.2	P35212	CXA4_HUMAN	gap junction protein, alpha 4, 37kDa	52					cell-cell junction assembly	integral to plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(4)|stomach(1)	14		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AATCAGATTTCGAGTGTAACA	0.597													48	91					0	0	1	0	0	T	35259970	C	T	35259970	2	4	48	1	0	0	0	0	0	0	0	1	6444	883	31	1		1	GJA4	1	35259970	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1093725	35259970	213990651	62	4456										
ZMYM6	9204	broad.mit.edu	37	chr1	35476172	35476172	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtattcatcagagcaattCttgccacaaaacagaaacat	5	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:35476172C>A	ENST00000357182.4	-	10	1595	c.1368G>T	c.(1366-1368)aaG>aaT	p.K456N	ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000373340.2_Missense_Mutation_p.K456N|ZMYM6_ENST00000487874.1_Missense_Mutation_p.K456N	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	456					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CAGAGCAATTCTTGCCACAAA	0.368													25	59					5.35047e-06	5.94462e-06	1	1	0	A	35476172	C	A	35476172	3	1	48	1	0	0	0	0	1	0	0	0	17761	912	32	2	2637	2	ZMYM6	1	35476172	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	216202	35476172	213774449	63	4457										
ZMYM4	9202	broad.mit.edu	37	chr1	35836059	35836059	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagttccagccacagctgttCgagtttcctgttctggttgt	10	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:35836059C>T	ENST00000314607.6	+	7	1092	c.1012C>T	c.(1012-1014)Cga>Tga	p.R338*	ZMYM4_ENST00000482131.1_3'UTR|ZMYM4_ENST00000373297.2_Nonsense_Mutation_p.R338*	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	338					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CACAGCTGTTCGAGTTTCCTG	0.458													18	32					0	0	1	0	0	T	35836059	C	T	35836059	4	4	48	1	0	0	0	0	0	1	0	0	17759	876	31	1	1038	1	ZMYM4	1	35836059	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	359887	35836059	213414562	64	4458										
KIAA0319L	79932	broad.mit.edu	37	chr1	35972481	35972481	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcatctgcagtttggaatTtttttaaaaacaccagcatg	6	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:35972481T>G	ENST00000325722.3	-	3	632	c.398A>C	c.(397-399)aAa>aCa	p.K133T		NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	133						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGTTTGGAATTTTTTTAAAAA	0.512													34	54					0	0	1	0	0	G	35972481	T	G	35972481	3	3	48	1	0	0	0	0	1	0	0	0	8210	1841	64	4	2827	4	KIAA0319L	1	35972481	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	136422	35972481	213278140	65	4459										
CLSPN	63967	broad.mit.edu	37	chr1	36214035	36214035	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagctgaccaaactggctcGaaatagcccaggggaaggag	14	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:36214035G>A	ENST00000251195.5	-	13	2539	c.2443C>T	c.(2443-2445)Cga>Tga	p.R815*	CLSPN_ENST00000373220.3_Nonsense_Mutation_p.R751*|CLSPN_ENST00000520551.1_Nonsense_Mutation_p.R762*|CLSPN_ENST00000318121.3_Nonsense_Mutation_p.R815*			Q9HAW4	CLSPN_HUMAN	claspin	815					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAACTGGCTCGAAATAGCCCA	0.468													54	92					0	0	1	0	0	A	36214035	G	A	36214035	4	1	48	1	0	0	0	0	0	1	0	0	3583	1066	37	1	1628	1	CLSPN	1	36214035	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	241554	36214035	213036586	66	4460										
GRIK3	2899	broad.mit.edu	37	chr1	37325529	37325529	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacttctccacaatggccgaGacgtgtgggttgtccacatt	10	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:37325529G>A	ENST00000373091.3	-	6	892	c.876C>T	c.(874-876)gtC>gtT	p.V292V	GRIK3_ENST00000373093.4_Silent_p.V292V	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	292					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CAATGGCCGAGACGTGTGGGT	0.587													36	65					0	0	1	0	0	A	37325529	G	A	37325529	2	1	48	1	0	0	0	0	0	0	0	1	6815	929	33	3		3	GRIK3	1	37325529	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1111494	37325529	211925092	67	4461										
DNALI1	7802	broad.mit.edu	37	chr1	38025037	38025037	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagacttaaagctgcagcagCggcaggccagggaaacaggc	14	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:38025037C>T	ENST00000296218.7	+	3	413	c.403C>T	c.(403-405)Cgg>Tgg	p.R135W	DNALI1_ENST00000541606.1_Intron	NM_003462.3	NP_003453.2	O14645	IDLC_HUMAN	dynein, axonemal, light intermediate chain 1	113					cellular component movement|single fertilization	axonemal dynein complex	microtubule motor activity			breast(1)|kidney(1)|large_intestine(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCTGCAGCAGCGGCAGGCCAG	0.592													21	35					0	0	1	0	0	T	38025037	C	T	38025037	3	4	48	1	0	0	0	0	1	0	0	0	4686	759	27	1	413	1	DNALI1	1	38025037	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	699508	38025037	211225584	68	4462										
GNL2	29889	broad.mit.edu	37	chr1	38034732	38034732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattttaccaaagttctgccGaactcgtgtgagaatctgct	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:38034732G>A	ENST00000373062.3	-	13	1686	c.1588C>T	c.(1588-1590)Cgg>Tgg	p.R530W	GNL2_ENST00000462812.1_5'UTR	NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	530					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding	p.R530W(1)		breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				AAGTTCTGCCGAACTCGTGTG	0.468													33	45					0	0	1	0	0	A	38034732	G	A	38034732	3	1	48	1	0	0	0	0	1	0	0	0	6577	1057	37	1	623	1	GNL2	1	38034732	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9695	38034732	211215889	69	4463										
YRDC	79693	broad.mit.edu	37	chr1	38272619	38272619	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagccaagtcttgcataaaAgcatgatcaggaatccgaat	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:38272619A>C	ENST00000373044.2	-	3	538	c.534T>G	c.(532-534)gcT>gcG	p.A178A		NM_024640.3	NP_078916.3	Q86U90	YRDC_HUMAN	yrdC N(6)-threonylcarbamoyltransferase domain containing	178	YrdC-like.				negative regulation of transport	membrane|mitochondrion				lung(2)|upper_aerodigestive_tract(1)	3	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTTGCATAAAAGCATGATCAG	0.488													30	51					0	0	1	0	0	C	38272619	A	C	38272619	2	2	48	1	0	0	0	0	0	0	0	1	17553	59	3	4		4	YRDC	1	38272619	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	237887	38272619	210978002	70	4464										
MTF1	4520	broad.mit.edu	37	chr1	38304324	38304324	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttttcccctgtatgagttCgaatgtgcttcctcagatca	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:38304324C>T	ENST00000373036.4	-	4	892	c.752G>A	c.(751-753)cGa>cAa	p.R251Q		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	251						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding	p.R251Q(1)		endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGTATGAGTTCGAATGTGCTT	0.438													19	46					0	0	1	0	0	T	38304324	C	T	38304324	3	4	48	1	0	0	0	0	1	0	0	0	9969	884	31	1	1541	1	MTF1	1	38304324	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31705	38304324	210946297	71	4465										
GJA9	81025	broad.mit.edu	37	chr1	39340703	39340703	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaagttcttttccaaatatTttatgagtgtctttgttatt	5	4	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:39340703T>C	ENST00000454994.2	-	2	1344	c.1068A>G	c.(1066-1068)aaA>aaG	p.K356K	GJA9_ENST00000360786.3_Silent_p.K356K|RP5-864K19.4_ENST00000443161.1_RNA|MYCBP_ENST00000489803.1_5'UTR|GJA9_ENST00000357771.3_Silent_p.K356K|RP5-864K19.4_ENST00000456813.1_RNA|RP5-864K19.4_ENST00000433671.2_RNA			P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	356					cell communication	connexon complex|integral to membrane				breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTCCAAATATTTTATGAGTGT	0.338													11	33					0	0	1	0	0	C	39340703	T	C	39340703	2	2	48	1	0	0	0	0	0	0	0	1	6447	1838	64	4		4	GJA9	1	39340703	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1036379	39340703	209909918	72	4466										
RHBDL2	54933	broad.mit.edu	37	chr1	39358897	39358897	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaatcatttcttgaaaattCttaaaaagagataaataata	5	3	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:39358897C>A	ENST00000289248.2	-	6	1618		c.e6-1		RHBDL2_ENST00000538156.1_Splice_Site|RP5-864K19.4_ENST00000433671.2_RNA|RHBDL2_ENST00000372985.3_Splice_Site|RHBDL2_ENST00000372990.1_Splice_Site			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CTTGAAAATTCTTAAAAAGAG	0.323													7	21					0.00198382	0.00207034	1	1	0	A	39358897	C	A	39358897	5	1	48	1	0	0	0	0	0	0	1	0	13371	927	32	2	314	2	RHBDL2	1	39358897	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18194	39358897	209891724	73	4467										
MACF1	23499	broad.mit.edu	37	chr1	39798397	39798397	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcctgagttccagttttcttCtcagaacaaagaatatcccg	7	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:39798397C>A	ENST00000564288.1	+	37	6914	c.6137C>A	c.(6136-6138)tCt>tAt	p.S2046Y	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.S2051Y|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.S486Y|MACF1_ENST00000567887.1_Missense_Mutation_p.S2083Y			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2051					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGTTTTCTTCTCAGAACAAA	0.433													18	59					5.01169e-05	5.45927e-05	1	1	0	A	39798397	C	A	39798397	3	1	48	1	0	0	0	0	1	0	0	0	9189	913	32	2	6228	2	MACF1	1	39798397	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	439500	39798397	209452224	74	4468										
MACF1	23499	broad.mit.edu	37	chr1	39800329	39800329	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctagaagcccaggcaaataCtggtggaatcatagatactg	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:39800329C>G	ENST00000564288.1	+	37	8846	c.8069C>G	c.(8068-8070)aCt>aGt	p.T2690S	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.T2695S|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.T1130S|MACF1_ENST00000567887.1_Missense_Mutation_p.T2727S			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2695					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGGCAAATACTGGTGGAATC	0.428													18	24					0	0	1	0	0	G	39800329	C	G	39800329	3	3	48	1	0	0	0	0	1	0	0	0	9189	565	20	5	8160	5	MACF1	1	39800329	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1932	39800329	209450292	75	4469										
MACF1	23499	broad.mit.edu	37	chr1	39801373	39801373	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaatgggattttctattaCttttaaaattgaagagtcct	7	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:39801373C>A	ENST00000564288.1	+	37	9890	c.9113C>A	c.(9112-9114)aCt>aAt	p.T3038N	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.T3043N|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.T1478N|MACF1_ENST00000567887.1_Missense_Mutation_p.T3075N			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3043					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTTCTATTACTTTTAAAATT	0.373													18	36					1.02788e-11	1.28326e-11	1	1	0	A	39801373	C	A	39801373	3	1	48	1	0	0	0	0	1	0	0	0	9189	565	20	5	9204	5	MACF1	1	39801373	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1044	39801373	209449248	76	4470										
KIAA0754	643314	broad.mit.edu	37	chr1	39878370	39878370	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctaaatatttttccagaGaaacaagttaccaaggctgg	7	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:39878370G>T	ENST00000530275.1	+	1	2220	c.2025G>T	c.(2023-2025)gaG>gaT	p.E675D	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000289893.4_Intron|MACF1_ENST00000567887.1_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	675										central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTTTCCAGAGAAACAAGTTA	0.453													6	38					0.0215528	0.0219788	1	1	0	T	39878370	G	T	39878370	3	4	48	1	0	0	0	0	1	0	0	0	8233	933	33	2	2435	2	KIAA0754	1	39878370	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	76997	39878370	209372251	77	4471										
NT5C1A	84618	broad.mit.edu	37	chr1	40131262	40131262	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttagtcatgaggacgatgtCgaagacgtcctcactatcag	11	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40131262C>T	ENST00000235628.1	-	3	363	c.364G>A	c.(364-366)Gac>Aac	p.D122N		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	122					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGGACGATGTCGAAGACGTCC	0.577													12	27					0	0	1	0	0	T	40131262	C	T	40131262	3	4	48	1	0	0	0	0	1	0	0	0	10732	884	31	1	758	1	NT5C1A	1	40131262	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	252892	40131262	209119359	78	4472										
PPIE	10450	broad.mit.edu	37	chr1	40207070	40207070	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttgcttttgttgaatttGagttggcagaggtgagagtc	14	3	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40207070G>T	ENST00000324379.5	+	3	182	c.163G>T	c.(163-165)Gag>Tag	p.E55*	PPIE_ENST00000480169.1_3'UTR|PPIE_ENST00000372830.1_Nonsense_Mutation_p.E55*|PPIE_ENST00000356511.2_Nonsense_Mutation_p.E55*|PPIE_ENST00000470213.1_Nonsense_Mutation_p.E55*	NM_006112.3	NP_006103.1	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E (cyclophilin E)	55	RRM.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding			kidney(3)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	9	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TGTTGAATTTGAGTTGGCAGA	0.383													23	36					9.04412e-07	1.02139e-06	1	1	0	T	40207070	G	T	40207070	4	4	48	1	0	0	0	0	0	1	0	0	12370	1291	45	2	173	2	PPIE	1	40207070	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	75808	40207070	209043551	79	4473										
TRIT1	54802	broad.mit.edu	37	chr1	40319675	40319675	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaactttccagagcagagaTtcaatgtaataattggttcc	8	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40319675T>G	ENST00000316891.5	-	3	395	c.381A>C	c.(379-381)gaA>gaC	p.E127D	TRIT1_ENST00000545233.1_Intron|TRIT1_ENST00000491865.1_Intron|TRIT1_ENST00000441669.2_Intron|TRIT1_ENST00000537440.1_Intron|TRIT1_ENST00000544981.1_Missense_Mutation_p.E127D|TRIT1_ENST00000541099.1_Intron|TRIT1_ENST00000537223.1_Intron|TRIT1_ENST00000372818.1_Missense_Mutation_p.E127D	NM_017646.4	NP_060116.2	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1	127					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			breast(1)|large_intestine(5)|liver(1)|lung(3)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(1)	15	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGAGCAGAGATTCAATGTAAT	0.363													18	40					0	0	1	0	0	G	40319675	T	G	40319675	3	3	48	1	0	0	0	0	1	0	0	0	16620	1490	52	4	1058	4	TRIT1	1	40319675	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	112605	40319675	208930946	80	4474										
RLF	6018	broad.mit.edu	37	chr1	40701803	40701803	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggactggaaaactttaaaaCgacactgccaccaactttta	7	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40701803C>T	ENST00000372771.4	+	8	1456	c.1429C>T	c.(1429-1431)Cga>Tga	p.R477*		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	477					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AACTTTAAAACGACACTGCCA	0.398													33	52					0	0	1	0	0	T	40701803	C	T	40701803	4	4	48	1	0	0	0	0	0	1	0	0	13440	528	19	1	1459	1	RLF	1	40701803	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	382128	40701803	208548818	81	4475										
RLF	6018	broad.mit.edu	37	chr1	40705776	40705776	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacttaacattaagtaattCttcacagtccagtaatgatt	5	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40705776C>A	ENST00000372771.4	+	8	5429	c.5402C>A	c.(5401-5403)tCt>tAt	p.S1801Y		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1801					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TTAAGTAATTCTTCACAGTCC	0.358													39	48					4.92203e-23	6.86763e-23	1	1	0	A	40705776	C	A	40705776	3	1	48	1	0	0	0	0	1	0	0	0	13440	913	32	2	5432	2	RLF	1	40705776	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3973	40705776	208544845	82	4476										
TMCO2	127391	broad.mit.edu	37	chr1	40717052	40717052	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagaaggaagtggtctccGaattcaagacaataataatc	8	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40717052G>A	ENST00000372766.3	+	2	428	c.335G>A	c.(334-336)cGa>cAa	p.R112Q	TMCO2_ENST00000468258.1_3'UTR	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	112						integral to membrane		p.R112Q(1)		kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			AGTGGTCTCCGAATTCAAGAC	0.368													28	44					0	0	1	0	0	A	40717052	G	A	40717052	3	1	48	1	0	0	0	0	1	0	0	0	16055	1058	37	1	341	1	TMCO2	1	40717052	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11276	40717052	208533569	83	4477										
COL9A2	1298	broad.mit.edu	37	chr1	40775941	40775941	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaagattcacttaccgtctCtcccttgggccctgccatgc	7	17	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:40775941C>T	ENST00000372748.3	-	14	829	c.733G>A	c.(733-735)Gag>Aag	p.E245K		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	245	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CTTACCGTCTCTCCCTTGGGC	0.562													5	69					0	0	1	0	0	T	40775941	C	T	40775941	3	4	48	1	0	0	0	0	1	0	0	0	3731	922	32	3	1412	3	COL9A2	1	40775941	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	58889	40775941	208474680	84	4478										
SCMH1	22955	broad.mit.edu	37	chr1	41541092	41541092	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttctcagtattcacatcGgaggcaggatagggattctt	12	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:41541092G>A	ENST00000402904.2	-	9	1115	c.747C>T	c.(745-747)tcC>tcT	p.S249S	SCMH1_ENST00000372597.1_Silent_p.S202S|SCMH1_ENST00000361191.5_Silent_p.S188S|SCMH1_ENST00000337495.5_Silent_p.S259S|SCMH1_ENST00000326197.7_Silent_p.S249S|SCMH1_ENST00000372596.1_Silent_p.S188S|SCMH1_ENST00000456518.2_Silent_p.S91S|SCMH1_ENST00000397171.2_Silent_p.S188S|SCMH1_ENST00000397174.2_Silent_p.S229S|SCMH1_ENST00000372595.1_Silent_p.S188S|SCMH1_ENST00000361705.3_Silent_p.S202S	NM_001031694.2	NP_001026864.1	Q96GD3	SCMH1_HUMAN	sex comb on midleg homolog 1 (Drosophila)	249					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				TATTCACATCGGAGGCAGGAT	0.512													32	49					0	0	1	0	0	A	41541092	G	A	41541092	2	1	48	1	0	0	0	0	0	0	0	1	13961	1103	39	1		1	SCMH1	1	41541092	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	765151	41541092	207709529	85	4479										
FOXJ3	22887	broad.mit.edu	37	chr1	42744276	42744276	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcatcagatttttggatggCtgctctcatggtgagctgtg	13	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:42744276C>T	ENST00000372572.1	-	5	423	c.112G>A	c.(112-114)Gcc>Acc	p.A38T	FOXJ3_ENST00000361346.1_Missense_Mutation_p.A38T|FOXJ3_ENST00000361776.1_Missense_Mutation_p.A38T|FOXJ3_ENST00000372573.1_Missense_Mutation_p.A38T|FOXJ3_ENST00000545068.1_Missense_Mutation_p.A38T	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	38					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTTTGGATGGCTGCTCTCATG	0.433													8	115					0	0	1	0	0	T	42744276	C	T	42744276	3	4	48	1	0	0	0	0	1	0	0	0	6046	797	28	3	1800	3	FOXJ3	1	42744276	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1203184	42744276	206506345	86	4480										
RIMKLA	284716	broad.mit.edu	37	chr1	42875737	42875737	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacgatgtgccctacctgttCcagaagtacgtgaaggagtc	11	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:42875737C>T	ENST00000431473.3	+	4	693	c.564C>T	c.(562-564)ttC>ttT	p.F188F		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	188	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						CCTACCTGTTCCAGAAGTACG	0.512													7	119					0	0	1	0	0	T	42875737	C	T	42875737	2	4	48	1	0	0	0	0	0	0	0	1	13416	854	30	3		3	RIMKLA	1	42875737	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	131461	42875737	206374884	87	4481										
CCDC30	728621	broad.mit.edu	37	chr1	43031966	43031966	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttaaaatgtttgctttaGcatccatcatctggagaaaa	6	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:43031966G>T	ENST00000428554.2	+	13	1818		c.e13-1		CCDC30_ENST00000507855.1_Splice_Site|CCDC30_ENST00000342022.4_Splice_Site|CCDC30_ENST00000340612.4_Splice_Site|CCDC30_ENST00000390640.4_Splice_Site			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						GTTTGCTTTAGCATCCATCAT	0.383													9	10					2.52707e-12	3.18246e-12	1	1	0	T	43031966	G	T	43031966	5	4	48	1	0	0	0	0	0	0	1	0	2824	985	34	5	693	5	CCDC30	1	43031966	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	156229	43031966	206218655	88	4482										
CCDC30	728621	broad.mit.edu	37	chr1	43076678	43076678	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaaccaggaattgtcagaGaagctatctaagctacagca	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:43076678G>T	ENST00000428554.2	+	17	2556	c.1413G>T	c.(1411-1413)gaG>gaT	p.E471D	CCDC30_ENST00000507855.1_Missense_Mutation_p.E260D|CCDC30_ENST00000342022.4_Missense_Mutation_p.E471D|CCDC30_ENST00000340612.4_Missense_Mutation_p.E471D|CCDC30_ENST00000390640.4_Missense_Mutation_p.E260D			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	471										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						AATTGTCAGAGAAGCTATCTA	0.368													15	44					7.93312e-07	8.98086e-07	1	1	0	T	43076678	G	T	43076678	3	4	48	1	0	0	0	0	1	0	0	0	2824	933	33	2	1447	2	CCDC30	1	43076678	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	44712	43076678	206173943	89	4483										
PPIH	10465	broad.mit.edu	37	chr1	43124947	43124947	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttcagatgtgtttgacttCtttgcctgctccagaggggt	12	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:43124947C>A	ENST00000372549.1	+	2	238	c.102C>A	c.(100-102)ttC>ttA	p.F34L	PPIH_ENST00000455203.2_5'UTR|PPIH_ENST00000372550.1_5'UTR|PPIH_ENST00000304979.3_Intron			O43447	PPIH_HUMAN	peptidylprolyl isomerase H (cyclophilin H)	0	PPIase cyclophilin-type.				protein complex assembly|protein folding	cytoplasm|nuclear speck|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|ribonucleoprotein binding			endometrium(1)|large_intestine(1)|lung(2)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)			L-Proline(DB00172)	TGTTTGACTTCTTTGCCTGCT	0.478													47	94					4.10826e-27	5.81883e-27	1	1	0	A	43124947	C	A	43124947	3	1	48	1	0	0	0	0	1	0	0	0	12373	928	32	2		2	PPIH	1	43124947	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	48269	43124947	206125674	90	4484										
CLDN19	149461	broad.mit.edu	37	chr1	43205521	43205521	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggggcctaccgtccagggCgagcagcgagtcgtagagct	16	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:43205521C>T	ENST00000539749.1	-	1	404	c.214G>A	c.(214-216)Gcc>Acc	p.A72T	CLDN19_ENST00000372539.3_Missense_Mutation_p.A72T|CLDN19_ENST00000296387.1_Missense_Mutation_p.A72T	NM_001185117.1	NP_001172046.1	Q8N6F1	CLD19_HUMAN	claudin 19	72					calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding			breast(2)|large_intestine(1)|lung(2)|skin(1)	6	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCGTCCAGGGCGAGCAGCGAG	0.637													8	16					0	0	1	0	0	T	43205521	C	T	43205521	3	4	48	1	0	0	0	0	1	0	0	0	3503	768	27	1	596	1	CLDN19	1	43205521	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80574	43205521	206045100	91	4485										
SLC6A9	6536	broad.mit.edu	37	chr1	44474151	44474151	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtccagtacaccggcgcagTcatgcgtgttccaggggtta	13	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:44474151T>C	ENST00000372310.3	-	5	629	c.464A>G	c.(463-465)gAc>gGc	p.D155G	SLC6A9_ENST00000357730.2_Missense_Mutation_p.D174G|SLC6A9_ENST00000372307.3_Missense_Mutation_p.D90G|SLC6A9_ENST00000360584.2_Missense_Mutation_p.D228G|SLC6A9_ENST00000537678.1_Missense_Mutation_p.D90G|SLC6A9_ENST00000372306.3_Missense_Mutation_p.D155G|SLC6A9_ENST00000475075.2_Missense_Mutation_p.D44G	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	228						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	ACCGGCGCAGTCATGCGTGTT	0.592													38	67					0	0	1	0	0	C	44474151	T	C	44474151	3	2	48	1	0	0	0	0	1	0	0	0	14745	1667	58	4	1477	4	SLC6A9	1	44474151	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1268630	44474151	204776470	92	4486										
UROD	7389	broad.mit.edu	37	chr1	45481017	45481017	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggtcccccaggaggagatCgggcagttggtgaagcagat	16	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:45481017C>T	ENST00000246337.4	+	10	1070	c.951C>T	c.(949-951)atC>atT	p.I317I	UROD_ENST00000494399.1_3'UTR	NM_000374.4	NP_000365.3	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	317						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGGAGGAGATCGGGCAGTTGG	0.532									Porphyria Cutanea Tarda, Type II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	23					0	0	1	0	0	T	45481017	C	T	45481017	2	4	48	1	0	0	0	0	0	0	0	1	17088	874	31	1		1	UROD	1	45481017	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1006866	45481017	203769604	93	4487										
TESK2	10420	broad.mit.edu	37	chr1	45811195	45811195	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatcttgtcatccagtgagcTtagtcgcttcaccccaggtg	10	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:45811195T>G	ENST00000372086.3	-	11	1433	c.1033A>C	c.(1033-1035)Agc>Cgc	p.S345R	TESK2_ENST00000538496.1_Missense_Mutation_p.S262R|TESK2_ENST00000341771.6_Missense_Mutation_p.S316R|TESK2_ENST00000486676.1_5'UTR|TESK2_ENST00000372084.1_Missense_Mutation_p.S316R	NM_007170.2	NP_009101.2	Q96S53	TESK2_HUMAN	testis-specific kinase 2	345					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	32	Acute lymphoblastic leukemia(166;0.155)					TCCAGTGAGCTTAGTCGCTTC	0.488													22	30					0	0	1	0	0	G	45811195	T	G	45811195	3	3	48	1	0	0	0	0	1	0	0	0	15826	1609	56	4	686	4	TESK2	1	45811195	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	330178	45811195	203439426	94	4488										
TESK2	10420	broad.mit.edu	37	chr1	45812447	45812447	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcatcatagtccagcccgAaattctgtggatgggtatgg	12	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:45812447A>G	ENST00000372086.3	-	9	1197	c.797T>C	c.(796-798)tTc>tCc	p.F266S	TESK2_ENST00000538496.1_Missense_Mutation_p.F183S|TESK2_ENST00000341771.6_Intron|TESK2_ENST00000486676.1_5'UTR|TESK2_ENST00000372084.1_Intron	NM_007170.2	NP_009101.2	Q96S53	TESK2_HUMAN	testis-specific kinase 2	266	Protein kinase.				actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	32	Acute lymphoblastic leukemia(166;0.155)					GTCCAGCCCGAAATTCTGTGG	0.502													12	18					0	0	1	0	0	G	45812447	A	G	45812447	3	3	48	1	0	0	0	0	1	0	0	0	15826	246	9	4	930	4	TESK2	1	45812447	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1252	45812447	203438174	95	4489										
MAST2	23139	broad.mit.edu	37	chr1	46290212	46290212	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgacaactgagtcaggatgaTtgtaagttatggagaggaaa	13	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:46290212T>G	ENST00000361297.2	+	2	568	c.285T>G	c.(283-285)gaT>gaG	p.D95E	MAST2_ENST00000372009.2_Missense_Mutation_p.D95E	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	95					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GTCAGGATGATTGTAAGTTAT	0.398													45	89					0	0	1	0	0	G	46290212	T	G	46290212	3	3	48	1	0	0	0	0	1	0	0	0	9374	1490	52	4	291	4	MAST2	1	46290212	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	477765	46290212	202960409	96	4490										
CYP4B1	1580	broad.mit.edu	37	chr1	47279612	47279612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctactaccttgcagtcagcGatctcactctgttgatgcag	9	12	3	1	rs139750942		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:47279612G>A	ENST00000271153.4	+	6	685	c.649G>A	c.(649-651)Gat>Aat	p.D217N	CYP4B1_ENST00000452782.2_Missense_Mutation_p.D55N|CYP4B1_ENST00000371923.4_Missense_Mutation_p.D218N|CYP4B1_ENST00000371919.4_Missense_Mutation_p.D203N			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	217					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TGCAGTCAGCGATCTCACTCT	0.567													58	102					0	0	1	0	0	A	47279612	G	A	47279612	3	1	48	1	0	0	0	0	1	0	0	0	4208	1058	37	1	674	1	CYP4B1	1	47279612	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	989400	47279612	201971009	97	4491										
CYP4Z1	199974	broad.mit.edu	37	chr1	47534420	47534420	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccagactatgccaagattCtcctgaaaagacaaggtaaa	7	10	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:47534420C>A	ENST00000334194.3	+	2	307	c.304C>A	c.(304-306)Ctc>Atc	p.L102I		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	102						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						TGCCAAGATTCTCCTGAAAAG	0.478													24	63					7.87624e-14	1.01695e-13	1	1	0	A	47534420	C	A	47534420	3	1	48	1	0	0	0	0	1	0	0	0	4217	913	32	2	310	2	CYP4Z1	1	47534420	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	254808	47534420	201716201	98	4492										
BEND5	79656	broad.mit.edu	37	chr1	49208353	49208353	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggagcggggtaataggacGacgtatttgcttcctcactg	13	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:49208353G>A	ENST00000371833.3	-	4	922	c.836C>T	c.(835-837)tCg>tTg	p.S279L	AGBL4_ENST00000371838.1_Intron|AGBL4_ENST00000371839.1_Intron|BEND5_ENST00000476096.1_Intron	NM_024603.2	NP_078879.2	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	279										large_intestine(5)|lung(2)|skin(1)	8						GTAATAGGACGACGTATTTGC	0.483													35	51					0	0	1	0	0	A	49208353	G	A	49208353	3	1	48	1	0	0	0	0	1	0	0	0	1399	1059	37	1	441	1	BEND5	1	49208353	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1673933	49208353	200042268	99	4493										
RNF11	26994	broad.mit.edu	37	chr1	51735705	51735705	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctgactgaagaggaacaAattaggatagctcaaagaat	10	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:51735705A>C	ENST00000242719.3	+	2	687	c.201A>C	c.(199-201)caA>caC	p.Q67H	RNF11_ENST00000494873.1_Intron	NM_014372.4	NP_055187.1	Q9Y3C5	RNF11_HUMAN	ring finger protein 11	67					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	DNA binding|protein binding|zinc ion binding	p.0?(2)		large_intestine(1)	1						AAGAGGAACAAATTAGGATAG	0.408													30	40					0	0	1	0	0	C	51735705	A	C	51735705	3	2	48	1	0	0	0	0	1	0	0	0	13475	11	1	4	207	4	RNF11	1	51735705	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2527352	51735705	197514916	100	4494										
NRD1	4898	broad.mit.edu	37	chr1	52271205	52271205	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgcagatttctgtatcaaCggtgaaattagatggaaacg	11	6	2	3	rs113829213	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:52271205C>T	ENST00000354831.7	-	21	2532	c.2343G>A	c.(2341-2343)ccG>ccA	p.P781P	NRD1_ENST00000352171.7_Silent_p.P713P|NRD1_ENST00000539524.1_Silent_p.P649P|NRD1_ENST00000544028.1_Silent_p.P581P|NRD1_ENST00000485608.1_5'UTR	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	712					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TCTGTATCAACGGTGAAATTA	0.289													15	18					0	0	1	0	0	T	52271205	C	T	52271205	2	4	48	1	0	0	0	0	0	0	0	1	10692	523	19	1		1	NRD1	1	52271205	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	535500	52271205	196979416	101	4495										
ZFYVE9	9372	broad.mit.edu	37	chr1	52704252	52704252	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcactacagaattccttaAtatgacagagcatttctctg	7	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:52704252A>C	ENST00000287727.3	+	4	1335	c.1163A>C	c.(1162-1164)aAt>aCt	p.N388T	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.N388T|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.N388T|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.N388T	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	388					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GAATTCCTTAATATGACAGAG	0.373													31	51					0	0	1	0	0	C	52704252	A	C	52704252	3	2	48	1	0	0	0	0	1	0	0	0	17728	101	4	4	1169	4	ZFYVE9	1	52704252	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	433047	52704252	196546369	102	4496										
ZFYVE9	9372	broad.mit.edu	37	chr1	52704608	52704608	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcagtaacagaagaaaaaGaaatagaggaaagcaagtca	9	4	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:52704608G>T	ENST00000287727.3	+	4	1691	c.1519G>T	c.(1519-1521)Gaa>Taa	p.E507*	ZFYVE9_ENST00000361625.1_Nonsense_Mutation_p.E507*|ZFYVE9_ENST00000357206.2_Nonsense_Mutation_p.E507*|ZFYVE9_ENST00000371591.1_Nonsense_Mutation_p.E507*	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	507					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AGAAGAAAAAGAAATAGAGGA	0.388													12	47					0.00010058	0.000108553	1	1	0	T	52704608	G	T	52704608	4	4	48	1	0	0	0	0	0	1	0	0	17728	943	33	2	1525	2	ZFYVE9	1	52704608	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	356	52704608	196546013	103	4497										
ZCCHC11	23318	broad.mit.edu	37	chr1	52981573	52981573	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catagtatactttttcaagtCgaaagatgtgatctctttct	6	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:52981573C>T	ENST00000371544.3	-	3	1134	c.872G>A	c.(871-873)cGa>cAa	p.R291Q	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.R291Q|ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000355809.4_Missense_Mutation_p.R291Q	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	291					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TTTTTCAAGTCGAAAGATGTG	0.363													24	43					0	0	1	0	0	T	52981573	C	T	52981573	3	4	48	1	0	0	0	0	1	0	0	0	17638	884	31	1	4177	1	ZCCHC11	1	52981573	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	276965	52981573	196269048	104	4498										
ZCCHC11	23318	broad.mit.edu	37	chr1	52981592	52981592	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgaaagatgtgatctctttCtaagcgttcttctgcttgtt	8	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:52981592C>A	ENST00000371544.3	-	3	1115	c.853G>T	c.(853-855)Gaa>Taa	p.E285*	ZCCHC11_ENST00000257177.4_Nonsense_Mutation_p.E285*|ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000355809.4_Nonsense_Mutation_p.E285*	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	285					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TGATCTCTTTCTAAGCGTTCT	0.393													25	45					1.42536e-11	1.77514e-11	1	1	0	A	52981592	C	A	52981592	4	1	48	1	0	0	0	0	0	1	0	0	17638	922	32	2	4196	2	ZCCHC11	1	52981592	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19	52981592	196269029	105	4499										
ZCCHC11	23318	broad.mit.edu	37	chr1	52991830	52991830	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttctcaatttcttttacGgatttatcatttctagcttt	4	8	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:52991830G>A	ENST00000371544.3	-	2	385	c.123C>T	c.(121-123)tcC>tcT	p.S41S	ZCCHC11_ENST00000257177.4_Silent_p.S41S|ZCCHC11_ENST00000355809.4_Silent_p.S41S	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	41					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TTTCTTTTACGGATTTATCAT	0.274													9	27					0	0	1	0	0	A	52991830	G	A	52991830	2	1	48	1	0	0	0	0	0	0	0	1	17638	1103	39	1		1	ZCCHC11	1	52991830	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10238	52991830	196258791	106	4500										
ZYG11B	79699	broad.mit.edu	37	chr1	53237447	53237447	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcgaaggacatttgaagGttagactttaaaaatgtatt	10	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:53237447G>A	ENST00000294353.6	+	3	1096		c.e3+1		ZYG11B_ENST00000443756.2_Splice_Site|ZYG11B_ENST00000545132.1_Splice_Site	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator								protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						ACATTTGAAGGTTAGACTTTA	0.363													8	71					0	0	1	0	0	A	53237447	G	A	53237447	5	1	48	1	0	0	0	0	0	0	1	0	18292	1275	44	3	962	3	ZYG11B	1	53237447	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	245617	53237447	196013174	107	4501										
GLIS1	148979	broad.mit.edu	37	chr1	54060081	54060081	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagacaggggataggggggCggcaggccctgctggtgagg	22	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:54060081C>T	ENST00000312233.2	-	3	1061	c.495G>A	c.(493-495)ccG>ccA	p.P165P		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	165					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GATAGGGGGGCGGCAGGCCCT	0.682													7	27					0	0	1	0	0	T	54060081	C	T	54060081	2	4	48	1	0	0	0	0	0	0	0	1	6486	755	27	1		1	GLIS1	1	54060081	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	822634	54060081	195190540	108	4502										
SSBP3	23648	broad.mit.edu	37	chr1	54717490	54717490	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgtcgtgtgggatccataGaattgggcagcaatggctgt	15	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:54717490G>T	ENST00000371320.3	-	8	961	c.551C>A	c.(550-552)tCt>tAt	p.S184Y	SSBP3_ENST00000417664.2_Missense_Mutation_p.S74Y|SSBP3_ENST00000371319.3_Missense_Mutation_p.S157Y|SSBP3_ENST00000357475.4_Missense_Mutation_p.S164Y|SSBP3_ENST00000326956.7_5'UTR	NM_145716.2	NP_663768.1	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3	184	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	11						GGGATCCATAGAATTGGGCAG	0.622													7	25					0.0293803	0.0299069	1	1	0	T	54717490	G	T	54717490	3	4	48	1	0	0	0	0	1	0	0	0	15236	942	33	2	659	2	SSBP3	1	54717490	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	657409	54717490	194533131	109	4503										
PCSK9	255738	broad.mit.edu	37	chr1	55523792	55523792	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatccacttctctgccaaaGatgtcatcaatgaggcctgg	9	11	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:55523792G>T	ENST00000302118.5	+	8	1554	c.1264G>T	c.(1264-1266)Gat>Tat	p.D422Y	PCSK9_ENST00000490692.1_3'UTR|PCSK9_ENST00000543384.1_Missense_Mutation_p.D222Y	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	422	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						CTCTGCCAAAGATGTCATCAA	0.622													22	59					1.96895e-08	2.32153e-08	1	1	0	T	55523792	G	T	55523792	3	4	48	1	0	0	0	0	1	0	0	0	11652	942	33	2	1294	2	PCSK9	1	55523792	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	806302	55523792	193726829	110	4504										
USP24	23358	broad.mit.edu	37	chr1	55567292	55567292	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcatatacagctgctggaAgactgcattcatataacaag	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:55567292A>G	ENST00000294383.6	-	43	5109	c.5110T>C	c.(5110-5112)Ttc>Ctc	p.F1704L	USP24_ENST00000407756.1_Missense_Mutation_p.F1544L	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1704					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						AGCTGCTGGAAGACTGCATTC	0.443													4	17					0	0	1	0	0	G	55567292	A	G	55567292	3	3	48	1	0	0	0	0	1	0	0	0	17114	72	3	4	2856	4	USP24	1	55567292	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	43500	55567292	193683329	111	4505										
USP24	23358	broad.mit.edu	37	chr1	55567320	55567320	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatataacaagttgcaccAccatttctcagccccacaaa	3	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:55567320A>G	ENST00000294383.6	-	43	5081	c.5082T>C	c.(5080-5082)ggT>ggC	p.G1694G	USP24_ENST00000407756.1_Silent_p.G1534G	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1694					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						AAGTTGCACCACCATTTCTCA	0.458													4	19					0	0	1	0	0	G	55567320	A	G	55567320	2	3	48	1	0	0	0	0	0	0	0	1	17114	146	6	4		4	USP24	1	55567320	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	28	55567320	193683301	112	4506										
USP24	23358	broad.mit.edu	37	chr1	55613398	55613398	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggccacagcagctgcaagcCgatgacaagcgatcaaactt	10	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:55613398C>T	ENST00000294383.6	-	18	2041	c.2042G>A	c.(2041-2043)cGg>cAg	p.R681Q	USP24_ENST00000407756.1_Missense_Mutation_p.R521Q	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	681					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						AGCTGCAAGCCGATGACAAGC	0.458													7	15					0	0	1	0	0	T	55613398	C	T	55613398	3	4	48	1	0	0	0	0	1	0	0	0	17114	652	23	1	6024	1	USP24	1	55613398	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	46078	55613398	193637223	113	4507										
USP24	23358	broad.mit.edu	37	chr1	55624553	55624553	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacaaatgaaaaacttacttCtttgagagaattcatcttag	5	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:55624553C>A	ENST00000294383.6	-	10	1224	c.1225G>T	c.(1225-1227)Gaa>Taa	p.E409*	USP24_ENST00000407756.1_Nonsense_Mutation_p.E297*	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	409					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						AAACTTACTTCTTTGAGAGAA	0.348													5	11					0.000602214	0.000636035	1	1	0	A	55624553	C	A	55624553	4	1	48	1	0	0	0	0	0	1	0	0	17114	922	32	2	6873	2	USP24	1	55624553	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11155	55624553	193626068	114	4508										
C8B	732	broad.mit.edu	37	chr1	57415369	57415369	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attttctctgtgacattgcgTtcaaaatctgagtatgattc	7	7	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:57415369T>C	ENST00000543257.1	-	7	1133	c.567A>G	c.(565-567)gaA>gaG	p.E189E	C8B_ENST00000371237.4_Silent_p.E241E|C8B_ENST00000535057.1_Silent_p.E179E	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	241	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGACATTGCGTTCAAAATCTG	0.333													10	20					0	0	1	0	0	C	57415369	T	C	57415369	2	2	48	1	0	0	0	0	0	0	0	1	2433	1722	60	4		4	C8B	1	57415369	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1790816	57415369	191835252	115	4509										
C8B	732	broad.mit.edu	37	chr1	57425735	57425735	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgtggtccaagaggaccaActagacagctcacaatcaat	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:57425735A>G	ENST00000543257.1	-	3	617	c.51T>C	c.(49-51)agT>agC	p.S17S	C8B_ENST00000371237.4_Silent_p.S69S|C8B_ENST00000494324.1_Intron|C8B_ENST00000535057.1_5'UTR	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	69					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex		p.S69R(1)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						AAGAGGACCAACTAGACAGCT	0.507													17	46					0	0	1	0	0	G	57425735	A	G	57425735	2	3	48	1	0	0	0	0	0	0	0	1	2433	40	2	4		4	C8B	1	57425735	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	10366	57425735	191824886	116	4510										
MYSM1	114803	broad.mit.edu	37	chr1	59147640	59147640	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcctctaccatttggcaaGaatgaaaaagcatttcatta	5	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:59147640G>T	ENST00000472487.1	-	8	1115	c.1076C>A	c.(1075-1077)tCt>tAt	p.S359Y	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	359					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					CATTTGGCAAGAATGAAAAAG	0.368													20	32					2.4624e-09	2.95225e-09	1	1	0	T	59147640	G	T	59147640	3	4	48	1	0	0	0	0	1	0	0	0	10148	942	33	2	1462	2	MYSM1	1	59147640	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1721905	59147640	190102981	117	4511										
MYSM1	114803	broad.mit.edu	37	chr1	59160818	59160818	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacaataaggccattctctgTtctccaagatgaatcaagat	6	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:59160818T>C	ENST00000472487.1	-	2	169	c.130A>G	c.(130-132)Aca>Gca	p.T44A		NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	44					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					CCATTCTCTGTTCTCCAAGAT	0.274													8	9					0	0	1	0	0	C	59160818	T	C	59160818	3	2	48	1	0	0	0	0	1	0	0	0	10148	1725	60	4	2432	4	MYSM1	1	59160818	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	13178	59160818	190089803	118	4512										
INADL	10207	broad.mit.edu	37	chr1	62350017	62350017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatcaacaccaagcgacacGagttatttccaaggcctcag	7	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:62350017G>A	ENST00000371158.2	+	22	3182	c.3068G>A	c.(3067-3069)cGa>cAa	p.R1023Q	INADL_ENST00000316485.6_Missense_Mutation_p.R1023Q	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1023					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CAAGCGACACGAGTTATTTCC	0.413													33	69					0	0	1	0	0	A	62350017	G	A	62350017	3	1	48	1	0	0	0	0	1	0	0	0	7774	1058	37	1	3150	1	INADL	1	62350017	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3189199	62350017	186900604	119	4513										
L1TD1	54596	broad.mit.edu	37	chr1	62676247	62676247	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagaactctgcacacagaaGaactaacatccaaagaagca	6	11	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:62676247G>T	ENST00000498273.1	+	4	2096	c.1801G>T	c.(1801-1803)Gaa>Taa	p.E601*		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	601										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						GCACACAGAAGAACTAACATC	0.348													11	21					2.80697e-09	3.36108e-09	1	1	0	T	62676247	G	T	62676247	4	4	48	1	0	0	0	0	0	1	0	0	8627	943	33	2	1807	2	L1TD1	1	62676247	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	326230	62676247	186574374	120	4514										
KANK4	163782	broad.mit.edu	37	chr1	62703978	62703978	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagggacctgccctgctccgCgtgggctctcagaagcccag	13	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:62703978C>A	ENST00000371153.4	-	10	3337	c.2959G>T	c.(2959-2961)Gcg>Tcg	p.A987S	KANK4_ENST00000317477.4_Missense_Mutation_p.A125S|KANK4_ENST00000371150.1_Missense_Mutation_p.A343S|KANK4_ENST00000354381.3_Missense_Mutation_p.A359S	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	987			A -> V (in dbSNP:rs34591898).							NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CCCTGCTCCGCGTGGGCTCTC	0.577													21	31					7.41877e-09	8.8016e-09	1	1	0	A	62703978	C	A	62703978	3	1	48	1	0	0	0	0	1	0	0	0	8022	768	27	5	32	5	KANK4	1	62703978	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	27731	62703978	186546643	121	4515										
KANK4	163782	broad.mit.edu	37	chr1	62739628	62739628	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaactccagctctcgaattCtttgctccctagctttgatt	6	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:62739628C>A	ENST00000371153.4	-	3	1526	c.1148G>T	c.(1147-1149)aGa>aTa	p.R383I	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	383										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CTCTCGAATTCTTTGCTCCCT	0.537													38	80					6.29468e-14	8.13866e-14	1	1	0	A	62739628	C	A	62739628	3	1	48	1	0	0	0	0	1	0	0	0	8022	913	32	2	1871	2	KANK4	1	62739628	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	35650	62739628	186510993	122	4516										
DOCK7	85440	broad.mit.edu	37	chr1	63128788	63128788	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagatctgcttcctaacttCggctgccaccgttctacaat	8	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:63128788C>T	ENST00000251157.5	-	2	85	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	DOCK7_ENST00000404627.2_Missense_Mutation_p.E18K|DOCK7_ENST00000340370.5_Missense_Mutation_p.E18K	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	18					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TTCCTAACTTCGGCTGCCACC	0.358													28	64					0	0	1	0	0	T	63128788	C	T	63128788	3	4	48	1	0	0	0	0	1	0	0	0	4719	893	31	1	6469	1	DOCK7	1	63128788	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	389160	63128788	186121833	123	4517										
ALG6	29929	broad.mit.edu	37	chr1	63894714	63894714	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaaaagacttctgaagaaGaactgcagttgaaatccttt	8	6	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:63894714G>T	ENST00000371108.4	+	14	1548	c.1243G>T	c.(1243-1245)Gaa>Taa	p.E415*	ALG6_ENST00000263440.4_Nonsense_Mutation_p.E417*|ALG6_ENST00000494765.1_3'UTR	NM_013339.3	NP_037471.2	Q9Y672	ALG6_HUMAN	ALG6, alpha-1,3-glucosyltransferase	415					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						TTCTGAAGAAGAACTGCAGTT	0.313													8	8					1.06961e-07	1.24214e-07	1	1	0	T	63894714	G	T	63894714	4	4	48	1	0	0	0	0	0	1	0	0	518	943	33	2	1293	2	ALG6	1	63894714	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	765926	63894714	185355907	124	4518										
ITGB3BP	23421	broad.mit.edu	37	chr1	63955791	63955791	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtgcttttgctcttcagaActtgtgggagaagcaaatag	11	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:63955791A>G	ENST00000371092.3	-	4	324	c.264T>C	c.(262-264)agT>agC	p.S88S	ITGB3BP_ENST00000271002.10_Silent_p.S49S|ITGB3BP_ENST00000283568.8_Silent_p.S49S	NM_001206739.1	NP_001193668.1	Q13352	CENPR_HUMAN	integrin beta 3 binding protein (beta3-endonexin)	49					apoptosis|cell adhesion|CenH3-containing nucleosome assembly at centromere|induction of apoptosis by extracellular signals|mitotic prometaphase|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome, centromeric region|cytosol|membrane fraction|nucleoplasm	protein C-terminus binding|signal transducer activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9						GCTCTTCAGAACTTGTGGGAG	0.328													7	47					0	0	1	0	0	G	63955791	A	G	63955791	2	3	48	1	0	0	0	0	0	0	0	1	7939	40	2	4		4	ITGB3BP	1	63955791	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	61077	63955791	185294830	125	4519										
ROR1	4919	broad.mit.edu	37	chr1	64605808	64605808	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagctgccttcactatgatTggcacttccagtcacttatc	6	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:64605808T>C	ENST00000371079.1	+	6	1002	c.627T>C	c.(625-627)atT>atC	p.I209I	RP11-24J23.2_ENST00000424995.1_RNA|ROR1_ENST00000545203.1_5'UTR|ROR1_ENST00000371080.1_Silent_p.I209I|ROR1_ENST00000482426.1_3'UTR	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	209	FZ.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						TCACTATGATTGGCACTTCCA	0.438													14	22					0	0	1	0	0	C	64605808	T	C	64605808	2	2	48	1	0	0	0	0	0	0	0	1	13577	1800	63	4		4	ROR1	1	64605808	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	650017	64605808	184644813	126	4520										
SGIP1	84251	broad.mit.edu	37	chr1	67109320	67109320	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagattaaaccattgcaatCtaaagacattcttaagaatg	5	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:67109320C>T	ENST00000371037.4	+	7	454	c.377C>T	c.(376-378)tCt>tTt	p.S126F	SGIP1_ENST00000371035.3_Missense_Mutation_p.S83F|SGIP1_ENST00000371036.3_Missense_Mutation_p.S101F|SGIP1_ENST00000371039.1_Missense_Mutation_p.S102F|SGIP1_ENST00000237247.6_Missense_Mutation_p.S130F|SGIP1_ENST00000468286.1_3'UTR	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	126					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CCATTGCAATCTAAAGACATT	0.373													32	67					0	0	1	0	0	T	67109320	C	T	67109320	3	4	48	1	0	0	0	0	1	0	0	0	14259	913	32	3	403	3	SGIP1	1	67109320	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2503512	67109320	182141301	127	4521										
SGIP1	84251	broad.mit.edu	37	chr1	67199467	67199467	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgccaataccaaggaattCtgggtaaacatgccaaattt	8	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:67199467C>A	ENST00000371037.4	+	21	2012	c.1935C>A	c.(1933-1935)ttC>ttA	p.F645L	SGIP1_ENST00000371035.3_Missense_Mutation_p.F435L|SGIP1_ENST00000371036.3_Missense_Mutation_p.F447L|SGIP1_ENST00000371039.1_Missense_Mutation_p.F448L|SGIP1_ENST00000237247.6_Missense_Mutation_p.F676L|SGIP1_ENST00000435165.2_Missense_Mutation_p.F150L	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	645					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CCAAGGAATTCTGGGTAAACA	0.348													21	36					3.62473e-10	4.42315e-10	1	1	0	A	67199467	C	A	67199467	3	1	48	1	0	0	0	0	1	0	0	0	14259	912	32	2	2017	2	SGIP1	1	67199467	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	90147	67199467	182051154	128	4522										
MIER1	57708	broad.mit.edu	37	chr1	67423799	67423799	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggttatggtagtactgttCgactacctgaagaagatgag	12	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:67423799C>T	ENST00000357692.2	+	6	546	c.289C>T	c.(289-291)Cga>Tga	p.R97*	MIER1_ENST00000355356.3_Nonsense_Mutation_p.R80*|MIER1_ENST00000371016.1_Nonsense_Mutation_p.R97*|MIER1_ENST00000371014.1_Nonsense_Mutation_p.R133*|MIER1_ENST00000371018.3_Nonsense_Mutation_p.R97*|MIER1_ENST00000479067.1_3'UTR|MIER1_ENST00000355977.6_Nonsense_Mutation_p.R17*|MIER1_ENST00000401042.3_Nonsense_Mutation_p.R80*|MIER1_ENST00000401041.1_Nonsense_Mutation_p.R133*	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	104	Glu-rich.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						TAGTACTGTTCGACTACCTga	0.388													21	33					0	0	1	0	0	T	67423799	C	T	67423799	4	4	48	1	0	0	0	0	0	1	0	0	9627	876	31	1	492	1	MIER1	1	67423799	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	224332	67423799	181826822	129	4523										
IL23R	149233	broad.mit.edu	37	chr1	67724382	67724382	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacactggatataaaccccaAatttcaaattttctgcctga	4	10	2	1	rs139858085		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:67724382A>G	ENST00000347310.5	+	11	1632	c.1461A>G	c.(1459-1461)caA>caG	p.Q487Q	IL23R_ENST00000371002.1_3'UTR|IL23R_ENST00000473881.1_3'UTR|IL23R_ENST00000395227.1_Silent_p.Q232Q	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	487					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						ATAAACCCCAAATTTCAAATT	0.388													21	50					0	0	1	0	0	G	67724382	A	G	67724382	2	3	48	1	0	0	0	0	0	0	0	1	7719	11	1	4		4	IL23R	1	67724382	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	300583	67724382	181526239	130	4524										
LRRC7	57554	broad.mit.edu	37	chr1	70505121	70505121	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactgagtcccagttcctgaAaaggaatggcaggtatgaag	13	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:70505121A>C	ENST00000310961.5	+	22	3933	c.3515A>C	c.(3514-3516)aAa>aCa	p.K1172T	LRRC7_ENST00000415775.2_Missense_Mutation_p.K451T|LRRC7_ENST00000035383.5_Missense_Mutation_p.K1167T			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1167						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CAGTTCCTGAAAAGGAATGGC	0.512													23	58					0	0	1	0	0	C	70505121	A	C	70505121	3	2	48	1	0	0	0	0	1	0	0	0	9064	14	1	4	3574	4	LRRC7	1	70505121	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2780739	70505121	178745500	131	4525										
ANKRD13C	81573	broad.mit.edu	37	chr1	70742520	70742520	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggtgtaagagactgtcttCgaatcggctgccaaaaaaaa	11	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:70742520C>T	ENST00000370944.4	-	10	1536	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	ANKRD13C_ENST00000464236.1_5'UTR|ANKRD13C_ENST00000262346.6_Missense_Mutation_p.R373Q	NM_030816.4	NP_110443.3	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	408					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	19						AGACTGTCTTCGAATCGGCTG	0.313													22	29					0	0	1	0	0	T	70742520	C	T	70742520	3	4	48	1	0	0	0	0	1	0	0	0	639	884	31	1	418	1	ANKRD13C	1	70742520	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	237399	70742520	178508101	132	4526										
NEGR1	257194	broad.mit.edu	37	chr1	72058522	72058522	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaagaggcaggctcgcattGgttgtgcctagcttgttggc	14	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:72058522G>A	ENST00000357731.4	-	6	1157	c.918C>T	c.(916-918)acC>acT	p.T306T	NEGR1_ENST00000306821.3_Silent_p.T178T|NEGR1_ENST00000434200.1_Silent_p.T260T	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	306	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GGCTCGCATTGGTTGTGCCTA	0.463													28	47					0	0	1	0	0	A	72058522	G	A	72058522	2	1	48	1	0	0	0	0	0	0	0	1	10363	1335	47	3		3	NEGR1	1	72058522	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1316002	72058522	177192099	133	4527										
LRRIQ3	127255	broad.mit.edu	37	chr1	74649284	74649284	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacttcacaaaaacaaaatCtttttgaccttctcttatgt	3	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:74649284C>A	ENST00000354431.4	-	2	276	c.85G>T	c.(85-87)Gat>Tat	p.D29Y	LRRIQ3_ENST00000370909.2_Missense_Mutation_p.D29Y|LRRIQ3_ENST00000370911.3_Missense_Mutation_p.D29Y|LRRIQ3_ENST00000395089.1_Missense_Mutation_p.D29Y	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	29										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						aaaacaAAATCTTTTTGACCT	0.333													9	10					0.00621372	0.0064192	1	1	0	A	74649284	C	A	74649284	3	1	48	1	0	0	0	0	1	0	0	0	9074	913	32	2	1817	2	LRRIQ3	1	74649284	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2590762	74649284	174601337	134	4528										
FPGT	8790	broad.mit.edu	37	chr1	74670325	74670325	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcatccttctagtttgacGataggtaccacacatggagt	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:74670325G>A	ENST00000370898.2	+	4	631	c.594G>A	c.(592-594)acG>acA	p.T198T	FPGT_ENST00000370894.4_Intron|FPGT_ENST00000534056.1_Intron|FPGT-TNNI3K_ENST00000370895.1_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT_ENST00000524915.1_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron|TNNI3K_ENST00000370893.1_Intron	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						CTAGTTTGACGATAGGTACCA	0.373													12	29					0	0	1	0	0	A	74670325	G	A	74670325	2	1	48	1	0	0	0	0	0	0	0	1	6070	1045	37	1		1	FPGT	1	74670325	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	21041	74670325	174580296	135	4529										
C1orf173	127254	broad.mit.edu	37	chr1	75039084	75039084	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctccattgcttctttcttCtccagtgtatacgttttttg	5	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:75039084C>A	ENST00000326665.5	-	14	2528	c.2310G>T	c.(2308-2310)gaG>gaT	p.E770D	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	770	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTTCTTTCTTCTCCAGTGTAT	0.463													5	78					1.23904e-05	1.36503e-05	1	1	0	A	75039084	C	A	75039084	3	1	48	1	0	0	0	0	1	0	0	0	2027	912	32	2	2286	2	C1orf173	1	75039084	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	368759	75039084	174211537	136	4530										
ST6GALNAC3	256435	broad.mit.edu	37	chr1	77094422	77094422	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cataggtttatcactgaaaaGaaagtgtttgctaaatgggc	10	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:77094422G>T	ENST00000328299.3	+	5	997	c.849G>T	c.(847-849)aaG>aaT	p.K283N		NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	283					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						TCACTGAAAAGAAAGTGTTTG	0.388													28	49					7.41945e-09	8.8016e-09	1	1	0	T	77094422	G	T	77094422	3	4	48	1	0	0	0	0	1	0	0	0	15280	933	33	2	881	2	ST6GALNAC3	1	77094422	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2055338	77094422	172156199	137	4531										
ST6GALNAC5	81849	broad.mit.edu	37	chr1	77509986	77509986	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattgaccagacagagtgtgTcatccgcatgaatgacgccc	11	11	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:77509986T>C	ENST00000477717.1	+	3	594	c.359T>C	c.(358-360)gTc>gCc	p.V120A		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	120					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						ACAGAGTGTGTCATCCGCATG	0.612													4	57					0	0	1	0	0	C	77509986	T	C	77509986	3	2	48	1	0	0	0	0	1	0	0	0	15282	1667	58	4	369	4	ST6GALNAC5	1	77509986	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	415564	77509986	171740635	138	4532										
AK5	26289	broad.mit.edu	37	chr1	77752766	77752766	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccaggaaaagaagaccttAcctccactaaatggaggaca	9	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:77752766A>T	ENST00000344720.5	+	2	1149	c.123A>T	c.(121-123)ttA>ttT	p.L41F	AK5_ENST00000354567.2_Missense_Mutation_p.L67F|AK5_ENST00000317704.4_3'UTR	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	67					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						AGAAGACCTTACCTCCACTAA	0.363													5	61					0	0	1	0	0	T	77752766	A	T	77752766	3	4	48	1	0	0	0	0	1	0	0	0	440	388	14	4	207	4	AK5	1	77752766	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	242780	77752766	171497855	139	4533										
NEXN	91624	broad.mit.edu	37	chr1	78392235	78392235	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagtacgaggaagataaaaGaataagatatgaagaacaac	9	4	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:78392235G>T	ENST00000330010.8	+	6	731	c.434G>T	c.(433-435)aGa>aTa	p.R145I	NEXN_ENST00000457030.1_Missense_Mutation_p.R195I|NEXN_ENST00000334785.7_Missense_Mutation_p.R209I	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	209	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAAGATAAAAGAATAAGATAT	0.299													10	59					4.68919e-08	5.48405e-08	1	1	0	T	78392235	G	T	78392235	3	4	48	1	0	0	0	0	1	0	0	0	10401	942	33	2	648	2	NEXN	1	78392235	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	639469	78392235	170858386	140	4534										
NEXN	91624	broad.mit.edu	37	chr1	78401572	78401572	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaactgatcaaattaaaaaGgagtggctctattcaagcta	8	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:78401572G>T	ENST00000330010.8	+	10	1421	c.1124G>T	c.(1123-1125)aGg>aTg	p.R375M	NEXN_ENST00000480732.1_3'UTR|NEXN_ENST00000457030.1_Missense_Mutation_p.R425M|NEXN_ENST00000334785.7_Missense_Mutation_p.R439M	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	439	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		AAATTAAAAAGGAGTGGCTCT	0.313													13	19					7.03913e-09	8.36985e-09	1	1	0	T	78401572	G	T	78401572	3	4	48	1	0	0	0	0	1	0	0	0	10401	1000	35	5	1354	5	NEXN	1	78401572	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9337	78401572	170849049	141	4535										
NEXN	91624	broad.mit.edu	37	chr1	78401718	78401718	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaaagagcgagaagctgaaAattttcatgaggtatattac	9	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:78401718A>C	ENST00000330010.8	+	10	1567	c.1270A>C	c.(1270-1272)Aat>Cat	p.N424H	NEXN_ENST00000480732.1_3'UTR|NEXN_ENST00000457030.1_Missense_Mutation_p.N474H|NEXN_ENST00000334785.7_Missense_Mutation_p.N488H	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	488	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		AGAAGCTGAAAATTTTCATGA	0.294													14	25					0	0	1	0	0	C	78401718	A	C	78401718	3	2	48	1	0	0	0	0	1	0	0	0	10401	14	1	4	1500	4	NEXN	1	78401718	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	146	78401718	170848903	142	4536										
DNAJB4	11080	broad.mit.edu	37	chr1	78479068	78479068	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccaaacggatgaagatttCtcgaaaaaggctaaacgctg	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:78479068C>A	ENST00000370763.5	+	2	802	c.545C>A	c.(544-546)tCt>tAt	p.S182Y	GIPC2_ENST00000476882.1_Intron|DNAJB4_ENST00000487931.1_3'UTR	NM_007034.3	NP_008965.2	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	182					protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						ATGAAGATTTCTCGAAAAAGG	0.403													27	52					3.73808e-20	5.11168e-20	1	1	0	A	78479068	C	A	78479068	3	1	48	1	0	0	0	0	1	0	0	0	4649	913	32	2	551	2	DNAJB4	1	78479068	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	77350	78479068	170771553	143	4537										
LPHN2	23266	broad.mit.edu	37	chr1	82447575	82447575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctttttattaatgaggagaCtattgtgatggcatatctct	9	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:82447575C>T	ENST00000370728.1	+	21	3830	c.3185C>T	c.(3184-3186)aCt>aTt	p.T1062I	LPHN2_ENST00000359929.3_Missense_Mutation_p.T1049I|LPHN2_ENST00000271029.4_Missense_Mutation_p.T1077I|LPHN2_ENST00000335786.5_Missense_Mutation_p.T1062I|LPHN2_ENST00000370727.1_Missense_Mutation_p.T1077I|LPHN2_ENST00000370730.1_Missense_Mutation_p.T1062I|LPHN2_ENST00000370713.1_Missense_Mutation_p.T1049I|LPHN2_ENST00000370715.1_Missense_Mutation_p.T1049I|LPHN2_ENST00000370725.1_Missense_Mutation_p.T1077I|LPHN2_ENST00000370717.2_Missense_Mutation_p.T1077I|LPHN2_ENST00000319517.6_Missense_Mutation_p.T1049I|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000394879.1_Missense_Mutation_p.T1064I|LPHN2_ENST00000370723.1_Missense_Mutation_p.T1064I|LPHN2_ENST00000370721.1_Missense_Mutation_p.T987I			O95490	LPHN2_HUMAN	latrophilin 2	1062					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AATGAGGAGACTATTGTGATG	0.398													40	78					0	0	1	0	0	T	82447575	C	T	82447575	3	4	48	1	0	0	0	0	1	0	0	0	8960	565	20	3	3208	3	LPHN2	1	82447575	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3968507	82447575	166803046	144	4538										
TTLL7	79739	broad.mit.edu	37	chr1	84386806	84386806	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcgattttcatgttcttctCgtgagatctgctttcgtact	8	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:84386806C>T	ENST00000260505.8	-	12	1705	c.1328G>A	c.(1327-1329)cGa>cAa	p.R443Q	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	443					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ATGTTCTTCTCGTGAGATCTG	0.323													22	33					0	0	1	0	0	T	84386806	C	T	84386806	3	4	48	1	0	0	0	0	1	0	0	0	16793	884	31	1	1375	1	TTLL7	1	84386806	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1939231	84386806	164863815	145	4539										
TTLL7	79739	broad.mit.edu	37	chr1	84403608	84403608	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtaaaccatttgatggaaCgtttgctgcctttgttctca	8	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:84403608C>T	ENST00000260505.8	-	8	1192	c.815G>A	c.(814-816)cGt>cAt	p.R272H	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	272	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTTGATGGAACGTTTGCTGCC	0.368													8	86					0	0	1	0	0	T	84403608	C	T	84403608	3	4	48	1	0	0	0	0	1	0	0	0	16793	536	19	1	1904	1	TTLL7	1	84403608	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16802	84403608	164847013	146	4540										
LPAR3	23566	broad.mit.edu	37	chr1	85331550	85331550	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcctgtgttaaacatcaggAatacataggcaattccagcg	10	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:85331550A>C	ENST00000440886.1	-	1	292	c.254T>G	c.(253-255)tTc>tGc	p.F85C	LPAR3_ENST00000370611.3_Missense_Mutation_p.F85C|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	85					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						AAACATCAGGAATACATAGGC	0.463													82	124					0	0	1	0	0	C	85331550	A	C	85331550	3	2	48	1	0	0	0	0	1	0	0	0	8950	246	9	4	815	4	LPAR3	1	85331550	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	927942	85331550	163919071	147	4541										
BCL10	8915	broad.mit.edu	37	chr1	85736388	85736388	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttctgtgttttttctcgccGaatagattcaacaagggtgt	10	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:85736388G>A	ENST00000370580.1	-	2	996	c.259C>T	c.(259-261)Cgg>Tgg	p.R87W		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	87	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		TTTTCTCGCCGAATAGATTCA	0.353			T	IGH@	MALT								19	33					0	0	1	0	0	A	85736388	G	A	85736388	3	1	48	1	0	0	0	0	1	0	0	0	1360	1057	37	1	450	1	BCL10	1	85736388	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	404838	85736388	163514233	148	4542										
ODF2L	57489	broad.mit.edu	37	chr1	86826116	86826116	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcagtagtcacctgagttTtatacatttcaataagggtt	8	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:86826116T>G	ENST00000359242.3	-	12	1528	c.1247A>C	c.(1246-1248)aAa>aCa	p.K416T	ODF2L_ENST00000370567.1_Missense_Mutation_p.K387T|ODF2L_ENST00000370566.3_Missense_Mutation_p.K387T|ODF2L_ENST00000524695.1_5'UTR|ODF2L_ENST00000317336.7_Missense_Mutation_p.K416T|ODF2L_ENST00000394731.1_Missense_Mutation_p.K256T|ODF2L_ENST00000294678.2_Missense_Mutation_p.K387T	NM_001007022.2	NP_001007023.2	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like	416						centrosome				endometrium(2)|kidney(2)|large_intestine(10)|lung(6)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	24				all cancers(265;0.0313)|Epithelial(280;0.0611)		CACCTGAGTTTTATACATTTC	0.294													9	22					0	0	1	0	0	G	86826116	T	G	86826116	3	3	48	1	0	0	0	0	1	0	0	0	10875	1841	64	4	867	4	ODF2L	1	86826116	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1089728	86826116	162424505	149	4543										
CLCA1	1179	broad.mit.edu	37	chr1	86951095	86951095	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaaaatcaaaaatgcaatCtccgaagcacatgggaagtg	9	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:86951095C>A	ENST00000234701.3	+	7	1156	c.805C>A	c.(805-807)Ctc>Atc	p.L269I	CLCA1_ENST00000394711.1_Missense_Mutation_p.L269I			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	269					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AAAATGCAATCTCCGAAGCAC	0.378													30	51					5.45727e-16	7.22369e-16	1	1	0	A	86951095	C	A	86951095	3	1	48	1	0	0	0	0	1	0	0	0	3480	913	32	2	827	2	CLCA1	1	86951095	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	124979	86951095	162299526	150	4544										
CLCA4	22802	broad.mit.edu	37	chr1	87031554	87031554	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacaaaacataaagtgcaatTttagaagtacatgggaggtg	10	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:87031554T>A	ENST00000370563.3	+	6	847	c.805T>A	c.(805-807)Ttt>Att	p.F269I	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	269						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AAAGTGCAATTTTAGAAGTAC	0.343													25	34					0	0	1	0	0	A	87031554	T	A	87031554	3	1	48	1	0	0	0	0	1	0	0	0	3482	1841	64	4	827	4	CLCA4	1	87031554	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	80459	87031554	162219067	151	4545										
CLCA4	22802	broad.mit.edu	37	chr1	87036850	87036850	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcaagttcttgtattgatGaagtgaaacaaagtggggcc	12	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:87036850G>T	ENST00000370563.3	+	8	1315	c.1273G>T	c.(1273-1275)Gaa>Taa	p.E425*	CLCA4_ENST00000263723.5_Nonsense_Mutation_p.E138*|CLCA4_ENST00000496322.1_3'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	425	VWFA.					apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTGTATTGATGAAGTGAAACA	0.433													38	83					3.33393e-15	4.38315e-15	1	1	0	T	87036850	G	T	87036850	4	4	48	1	0	0	0	0	0	1	0	0	3482	1291	45	2	1303	2	CLCA4	1	87036850	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5296	87036850	162213771	152	4546										
PKN2	5586	broad.mit.edu	37	chr1	89271369	89271369	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctaggtatgtgtctgagaTtttaagcatctcttatacaa	8	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:89271369T>G	ENST00000316005.7	+	11	2050	c.1691T>G	c.(1690-1692)aTt>aGt	p.I564S	PKN2_ENST00000370521.3_Intron|PKN2_ENST00000370513.5_Intron|PKN2_ENST00000544045.1_Intron|PKN2_ENST00000370505.3_Intron			Q16513	PKN2_HUMAN	protein kinase N2	0					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GTGTCTGAGATTTTAAGCATC	0.433													9	13					0	0	1	0	0	G	89271369	T	G	89271369	3	3	48	1	0	0	0	0	1	0	0	0	12027	1508	52	4		4	PKN2	1	89271369	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2234519	89271369	159979252	153	4547										
RBMXL1	494115	broad.mit.edu	37	chr1	89449102	89449102	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaactcatgttaaaattCatggaatatccaccatcatc	5	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:89449102C>A	ENST00000399794.2	-	3	1123	c.408G>T	c.(406-408)atG>atT	p.M136I	RBMXL1_ENST00000321792.5_Missense_Mutation_p.M136I|CCBL2_ENST00000370491.3_Intron|RBMXL1_ENST00000413769.1_5'UTR|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000260508.4_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	136							nucleotide binding|RNA binding										TGTTAAAATTCATGGAATATC	0.517													45	85					1.41504e-22	1.969e-22	1	1	0	A	89449102	C	A	89449102	3	1	48	1	0	0	0	0	1	0	0	0	13204	826	29	2	768	2	RBMXL1	1	89449102	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	177733	89449102	159801519	154	4548										
GBP3	2635	broad.mit.edu	37	chr1	89476677	89476677	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagccccctggtttcgaataAattcccgccttcacttcttc	5	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:89476677A>C	ENST00000370481.4	-	8	1492	c.1272T>G	c.(1270-1272)atT>atG	p.I424M		NM_018284.2	NP_060754.2	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	424						integral to membrane	GTP binding|GTPase activity			breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		GTTTCGAATAAATTCCCGCCT	0.413													86	128					0	0	1	0	0	C	89476677	A	C	89476677	3	2	48	1	0	0	0	0	1	0	0	0	6314	10	1	4	531	4	GBP3	1	89476677	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	27575	89476677	159773944	155	4549										
GBP1	2633	broad.mit.edu	37	chr1	89523768	89523768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctacttgttgcacaaattCggggtccagctcttcatctt	8	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:89523768C>T	ENST00000370473.4	-	6	1000	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	261					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TGCACAAATTCGGGGTCCAGC	0.458													58	127					0	0	1	0	0	T	89523768	C	T	89523768	3	4	48	1	0	0	0	0	1	0	0	0	6312	893	31	1	1021	1	GBP1	1	89523768	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47091	89523768	159726853	156	4550										
GBP2	2634	broad.mit.edu	37	chr1	89585912	89585912	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcccatgctattgtacacGaaggtgctgctcaggaggat	12	9	1	0	rs148121752		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:89585912G>A	ENST00000370466.3	-	4	646	c.378C>T	c.(376-378)ttC>ttT	p.F126F		NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	126					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TATTGTACACGAAGGTGCTGC	0.458													29	69					0	0	1	0	0	A	89585912	G	A	89585912	2	1	48	1	0	0	0	0	0	0	0	1	6313	1049	37	1		1	GBP2	1	89585912	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	62144	89585912	159664709	157	4551										
GBP2	2634	broad.mit.edu	37	chr1	89587645	89587645	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggcaagttgatctctggaGccatgtccagggtgttgttc	13	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:89587645G>A	ENST00000370466.3	-	2	273	c.5C>T	c.(4-6)gCt>gTt	p.A2V		NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	2					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		GATCTCTGGAGCCATGTCCAG	0.443													32	65					0	0	1	0	0	A	89587645	G	A	89587645	3	1	48	1	0	0	0	0	1	0	0	0	6313	971	34	3	1810	3	GBP2	1	89587645	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1733	89587645	159662976	158	4552										
LRRC8B	23507	broad.mit.edu	37	chr1	90048689	90048689	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccatccttcacaagtgcttCgattctccatggaccacccg	7	16	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:90048689C>T	ENST00000330947.2	+	5	840	c.480C>T	c.(478-480)ttC>ttT	p.F160F	LRRC8B_ENST00000358200.4_Silent_p.F160F|LRRC8B_ENST00000439853.1_Silent_p.F160F	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	160						integral to membrane		p.F160F(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		ACAAGTGCTTCGATTCTCCAT	0.527													44	76					0	0	1	0	0	T	90048689	C	T	90048689	2	4	48	1	0	0	0	0	0	0	0	1	9066	883	31	1		1	LRRC8B	1	90048689	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	461044	90048689	159201932	159	4553										
ZNF644	84146	broad.mit.edu	37	chr1	91383672	91383672	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagcattttcttcttgcttCcagatcttgaccttgatttc	5	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:91383672C>T	ENST00000370440.1	-	5	3945	c.3728G>A	c.(3727-3729)gGa>gAa	p.G1243E	ZNF644_ENST00000347275.5_Missense_Mutation_p.G21E|ZNF644_ENST00000361321.5_Missense_Mutation_p.G21E|ZNF644_ENST00000337393.5_Missense_Mutation_p.G1243E|ZNF644_ENST00000467231.1_5'UTR			Q9H582	ZN644_HUMAN	zinc finger protein 644	1243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G1243A(1)		breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CTTCTTGCTTCCAGATCTTGA	0.358													16	16					0	0	1	0	0	T	91383672	C	T	91383672	3	4	48	1	0	0	0	0	1	0	0	0	18116	855	30	3	263	3	ZNF644	1	91383672	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1334983	91383672	157866949	160	4554										
ZNF644	84146	broad.mit.edu	37	chr1	91404618	91404618	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaatttaatgaactagcttCttcttttttgaaatgcacag	6	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:91404618C>A	ENST00000370440.1	-	3	2510	c.2293G>T	c.(2293-2295)Gaa>Taa	p.E765*	ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000337393.5_Nonsense_Mutation_p.E765*|ZNF644_ENST00000467231.1_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	765					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		GAACTAGCTTCTTCTTTTTTG	0.343													24	41					1.36565e-18	1.85171e-18	1	1	0	A	91404618	C	A	91404618	4	1	48	1	0	0	0	0	0	1	0	0	18116	922	32	2	1706	2	ZNF644	1	91404618	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	20946	91404618	157846003	161	4555										
HFM1	164045	broad.mit.edu	37	chr1	91845729	91845729	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttgttatagctagttcaAacactacagtttttccagaa	5	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:91845729A>G	ENST00000370425.3	-	8	1036	c.938T>C	c.(937-939)tTt>tCt	p.F313S	HFM1_ENST00000370424.3_5'UTR|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	313	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AGCTAGTTCAAACACTACAGT	0.284													20	34					0	0	1	0	0	G	91845729	A	G	91845729	3	3	48	1	0	0	0	0	1	0	0	0	7123	14	1	4	3497	4	HFM1	1	91845729	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	441111	91845729	157404892	162	4556										
CDC7	8317	broad.mit.edu	37	chr1	91967372	91967372	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttaaaaaaaaacgagcaGaattttaaacttgcaggtac	6	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:91967372G>T	ENST00000428239.1	+	2	358	c.99G>T	c.(97-99)caG>caT	p.Q33H	CDC7_ENST00000497611.1_3'UTR|CDC7_ENST00000234626.6_Missense_Mutation_p.Q33H|CDC7_ENST00000430031.2_Missense_Mutation_p.Q33H	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	33					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		AAAACGAGCAGAATTTTAAAC	0.393													4	69					0.150653	0.151842	1	1	0	T	91967372	G	T	91967372	3	4	48	1	0	0	0	0	1	0	0	0	3106	933	33	2	101	2	CDC7	1	91967372	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	121643	91967372	157283249	163	4557										
BRDT	676	broad.mit.edu	37	chr1	92467660	92467660	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgcatccatctggtgataGtgacacaacgatgttagaat	10	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:92467660G>T	ENST00000370389.2	+	16	3047	c.2123G>T	c.(2122-2124)aGt>aTt	p.S708I	BRDT_ENST00000402388.1_Missense_Mutation_p.S781I|BRDT_ENST00000394530.3_Missense_Mutation_p.S735I|BRDT_ENST00000399546.2_Missense_Mutation_p.S781I|BRDT_ENST00000362005.3_Missense_Mutation_p.S781I	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	781					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		TCTGGTGATAGTGACACAACG	0.338													6	26					0.00307968	0.00320271	1	1	0	T	92467660	G	T	92467660	3	4	48	1	0	0	0	0	1	0	0	0	1510	1029	36	5	2400	5	BRDT	1	92467660	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	500288	92467660	156782961	164	4558										
GLMN	11146	broad.mit.edu	37	chr1	92756986	92756986	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaacttacctttaccaataAatcaaagatcaaaaaataaa	1	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:92756986A>C	ENST00000370360.3	-	4	355	c.274T>G	c.(274-276)Tta>Gta	p.L92V	GLMN_ENST00000534881.1_Missense_Mutation_p.L92V	NM_053274.2	NP_444504.1	Q92990	GLMN_HUMAN	glomulin, FKBP associated protein	92					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	17		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TTTACCAATAAATCAAAGATC	0.308									Multiple Glomus Tumors (of the Skin), Familial				22	8					0	0	1	0	0	C	92756986	A	C	92756986	3	2	48	1	0	0	0	0	1	0	0	0	6489	11	1	4	1574	4	GLMN	1	92756986	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	289326	92756986	156493635	165	4559										
MTF2	22823	broad.mit.edu	37	chr1	93581174	93581174	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctattgtggaggccctggaGagtaagtaaatacagttatg	13	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:93581174G>A	ENST00000370298.4	+	6	920	c.632_splice	c.e6+1	p.D211_splice	MTF2_ENST00000471953.1_3'UTR|MTF2_ENST00000545708.1_Splice_Site_p.D109_splice|MTF2_ENST00000540243.1_Splice_Site_p.D109_splice|MTF2_ENST00000370303.4_Splice_Site_p.D211_splice	NM_001164392.1|NM_007358.3	NP_001157864.1|NP_031384.1	Q9Y483	MTF2_HUMAN	metal response element binding transcription factor 2	211						nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		AGGCCCTGGAGAGTAAGTAAA	0.383													4	51					0	0	1	0	0	A	93581174	G	A	93581174	5	1	48	1	0	0	0	0	0	0	1	0	9970	956	33	3	653	3	MTF2	1	93581174	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	824188	93581174	155669447	166	4560										
BCAR3	8412	broad.mit.edu	37	chr1	94027904	94027904	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgattgacttgtgcacctTtgctgccccatagcaatcgc	8	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:94027904T>C	ENST00000370244.1	-	14	2660	c.2372A>G	c.(2371-2373)aAa>aGa	p.K791R	BCAR3_ENST00000260502.6_Missense_Mutation_p.K791R|BCAR3_ENST00000370247.3_Missense_Mutation_p.K700R|BCAR3_ENST00000539242.1_Missense_Mutation_p.K467R|BCAR3_ENST00000370243.1_Missense_Mutation_p.K791R	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	791	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TTGTGCACCTTTGCTGCCCCA	0.388													33	49					0	0	1	0	0	C	94027904	T	C	94027904	3	2	48	1	0	0	0	0	1	0	0	0	1347	1841	64	4	109	4	BCAR3	1	94027904	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	446730	94027904	155222717	167	4561										
BCAR3	8412	broad.mit.edu	37	chr1	94032978	94032978	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttcaaaagtcacagcctgGcgctccattaacgtcacaag	7	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:94032978G>A	ENST00000370244.1	-	13	2445	c.2157C>T	c.(2155-2157)cgC>cgT	p.R719R	BCAR3_ENST00000260502.6_Silent_p.R719R|BCAR3_ENST00000370247.3_Silent_p.R628R|BCAR3_ENST00000539242.1_Silent_p.R395R|BCAR3_ENST00000370243.1_Silent_p.R719R	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	719	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TCACAGCCTGGCGCTCCATTA	0.483													8	53					0	0	1	0	0	A	94032978	G	A	94032978	2	1	48	1	0	0	0	0	0	0	0	1	1347	1190	42	3		3	BCAR3	1	94032978	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5074	94032978	155217643	168	4562										
DNTTIP2	30836	broad.mit.edu	37	chr1	94342350	94342350	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcacttgcttttatggggcTctttttgttgttattccatc	8	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:94342350T>G	ENST00000436063.2	-	2	1198	c.1141A>C	c.(1141-1143)Agc>Cgc	p.S381R	DNTTIP2_ENST00000460191.1_5'UTR	NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTTATGGGGCTCTTTTTGTTG	0.393													41	105					0	0	1	0	0	G	94342350	T	G	94342350	3	3	48	1	0	0	0	0	1	0	0	0	4709	1551	54	4	1153	4	DNTTIP2	1	94342350	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	309372	94342350	154908271	169	4563										
ABCA4	24	broad.mit.edu	37	chr1	94528743	94528743	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttcacgtggggtggtagaGagctggtccagggatacatg	16	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:94528743G>T	ENST00000370225.3	-	12	1771	c.1685C>A	c.(1684-1686)tCt>tAt	p.S562Y	ABCA4_ENST00000535735.1_Missense_Mutation_p.S562Y	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	562					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGGTGGTAGAGAGCTGGTCCA	0.493													49	101					2.52991e-16	3.36543e-16	1	1	0	T	94528743	G	T	94528743	3	4	48	1	0	0	0	0	1	0	0	0	34	942	33	2	5292	2	ABCA4	1	94528743	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	186393	94528743	154721878	170	4564										
TMEM56	148534	broad.mit.edu	37	chr1	95657239	95657239	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggcttcatgtattccgtgTatggaacagaaccctacata	8	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:95657239T>C	ENST00000370203.4	+	7	898	c.607T>C	c.(607-609)Tat>Cat	p.Y203H	RP11-57H12.3_ENST00000419846.1_RNA|RP11-57H12.3_ENST00000421762.1_RNA|RP11-57H12.6_ENST00000604534.1_Intron	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	203	TLC.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		GTATTCCGTGTATGGAACAGA	0.393													45	73					0	0	1	0	0	C	95657239	T	C	95657239	3	2	48	1	0	0	0	0	1	0	0	0	16242	1638	57	4	629	4	TMEM56	1	95657239	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1128496	95657239	153593382	171	4565										
DPYD	1806	broad.mit.edu	37	chr1	98015142	98015142	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatttgtgaatgtaccaagAagcttgctttccatcattca	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:98015142A>G	ENST00000370192.3	-	12	1598	c.1498T>C	c.(1498-1500)Tct>Cct	p.S500P		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	500					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ATGTACCAAGAAGCTTGCTTT	0.388													20	28					0	0	1	0	0	G	98015142	A	G	98015142	3	3	48	1	0	0	0	0	1	0	0	0	4771	246	9	4	1627	4	DPYD	1	98015142	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2357903	98015142	151235479	172	4566										
SNX7	51375	broad.mit.edu	37	chr1	99161227	99161227	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactatttagccagaaaataAatttgatagataaaatatct	4	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:99161227A>C	ENST00000370189.5	+	6	965	c.601A>C	c.(601-603)Aat>Cat	p.N201H	SNX7_ENST00000306121.3_Missense_Mutation_p.N265H|SNX7_ENST00000529992.1_Missense_Mutation_p.N210H			Q9UNH6	SNX7_HUMAN	sorting nexin 7	201					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		CCAGAAAATAAATTTGATAGA	0.338													6	54					0	0	1	0	0	C	99161227	A	C	99161227	3	2	48	1	0	0	0	0	1	0	0	0	14960	14	1	4	811	4	SNX7	1	99161227	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1146085	99161227	150089394	173	4567										
LPPR5	0	broad.mit.edu	37	chr1	99418684	99418684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttggatggaaaggtttttCgggctctcatgatgagatct	12	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:99418684C>T	ENST00000370188.3	-	3	923	c.563G>A	c.(562-564)cGa>cAa	p.R188Q	LPPR5_ENST00000263177.4_Missense_Mutation_p.R188Q	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		188						integral to membrane	hydrolase activity										AAAGGTTTTTCGGGCTCTCAT	0.418													23	34					0	0	1	0	0	T	99418684	C	T	99418684	3	4	48	1	0	0	0	0	1	0	0	0	8972	884	31	1	418	1	LPPR5	1	99418684	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	257457	99418684	149831937	174	4568										
LPPR4	0	broad.mit.edu	37	chr1	99771407	99771407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacagaaggcatcctcaaccGaaaccacagagatgctagct	8	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:99771407G>A	ENST00000370185.3	+	7	1630	c.1133G>A	c.(1132-1134)cGa>cAa	p.R378Q	LPPR4_ENST00000370184.1_Missense_Mutation_p.R220Q|LPPR4_ENST00000457765.1_Missense_Mutation_p.R320Q	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		378							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ATCCTCAACCGAAACCACAGA	0.458													26	51					0	0	1	0	0	A	99771407	G	A	99771407	3	1	48	1	0	0	0	0	1	0	0	0	8971	1058	37	1	1159	1	LPPR4	1	99771407	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	352723	99771407	149479214	175	4569										
LPPR4	0	broad.mit.edu	37	chr1	99771601	99771601	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcctctatggattccgctCgatcaaagcagctcctcacc	7	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:99771601C>T	ENST00000370185.3	+	7	1824	c.1327C>T	c.(1327-1329)Cga>Tga	p.R443*	LPPR4_ENST00000370184.1_Nonsense_Mutation_p.R285*|LPPR4_ENST00000457765.1_Nonsense_Mutation_p.R385*	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		443							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GGATTCCGCTCGATCAAAGCA	0.498													4	86					0	0	1	0	0	T	99771601	C	T	99771601	4	4	48	1	0	0	0	0	0	1	0	0	8971	876	31	1	1353	1	LPPR4	1	99771601	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	194	99771601	149479020	176	4570										
SLC35A3	23443	broad.mit.edu	37	chr1	100480922	100480922	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatggagaactggtatcaaaGaatggattttttcagggata	12	3	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:100480922G>T	ENST00000370155.3	+	6	1091	c.699G>T	c.(697-699)aaG>aaT	p.K233N	SLC35A3_ENST00000465289.1_Intron|SLC35A3_ENST00000427993.2_Missense_Mutation_p.K233N|SLC35A3_ENST00000370156.3_3'UTR|SLC35A3_ENST00000370153.1_Missense_Mutation_p.K275N	NM_012243.1	NP_036375.1	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3	233					UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity			biliary_tract(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	11		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		TGGTATCAAAGAATGGATTTT	0.299													12	25					7.03913e-09	8.36985e-09	1	1	0	T	100480922	G	T	100480922	3	4	48	1	0	0	0	0	1	0	0	0	14626	933	33	2	717	2	SLC35A3	1	100480922	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	709321	100480922	148769699	177	4571										
SASS6	163786	broad.mit.edu	37	chr1	100575956	100575956	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaactcagacagtctgttTtgtagctggtggatgttttg	11	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:100575956T>C	ENST00000287482.5	-	8	893	c.753A>G	c.(751-753)caA>caG	p.Q251Q	SASS6_ENST00000462159.1_5'UTR|SASS6_ENST00000535161.1_Silent_p.Q84Q	NM_194292.1	NP_919268.1	Q6UVJ0	SAS6_HUMAN	spindle assembly 6 homolog (C. elegans)	251					centriole replication	centriole				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	19		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		ACAGTCTGTTTTGTAGCTGGT	0.353													4	48					0	0	1	0	0	C	100575956	T	C	100575956	2	2	48	1	0	0	0	0	0	0	0	1	13902	1838	64	4		4	SASS6	1	100575956	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	95034	100575956	148674665	178	4572										
GPR88	54112	broad.mit.edu	37	chr1	101004646	101004646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactcctgtattcgggcctgGccatcgggggcacgctggcc	14	15	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:101004646G>A	ENST00000315033.4	+	2	563	c.124G>A	c.(124-126)Gcc>Acc	p.A42T		NM_022049.2	NP_071332.2	Q9GZN0	GPR88_HUMAN	G protein-coupled receptor 88	42						integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|skin(1)	3		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		TTCGGGCCTGGCCATCGGGGG	0.657													5	12					0	0	1	0	0	A	101004646	G	A	101004646	3	1	48	1	0	0	0	0	1	0	0	0	6756	1203	42	3	126	3	GPR88	1	101004646	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	428690	101004646	148245975	179	4573										
S1PR1	1901	broad.mit.edu	37	chr1	101704898	101704898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcccgcccagtggtttctgCgggaagggagtatgtttgtg	15	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:101704898C>T	ENST00000305352.6	+	2	733	c.358C>T	c.(358-360)Cgg>Tgg	p.R120W	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	120					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						GTGGTTTCTGCGGGAAGGGAG	0.552											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	53					0	0	1	0	0	T	101704898	C	T	101704898	3	4	48	1	0	0	0	0	1	0	0	0	13844	759	27	1	360	1	S1PR1	1	101704898	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	700252	101704898	147545723	180	4574										
S1PR1	1901	broad.mit.edu	37	chr1	101705191	101705191	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actctgcttctgctctccatCgtcattctgtactgcagaat	6	13	5	1	rs139640364		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:101705191C>T	ENST00000305352.6	+	2	1026	c.651C>T	c.(649-651)atC>atT	p.I217I		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	217					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						TGCTCTCCATCGTCATTCTGT	0.567													45	84					0	0	1	0	0	T	101705191	C	T	101705191	2	4	48	1	0	0	0	0	0	0	0	1	13844	874	31	1		1	S1PR1	1	101705191	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	293	101705191	147545430	181	4575										
COL11A1	1301	broad.mit.edu	37	chr1	103548435	103548435	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcagtatctgagcctttaGaattctttctgtttgtgcaa	8	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:103548435G>T	ENST00000358392.2	-	2	517	c.200C>A	c.(199-201)tCt>tAt	p.S67Y	COL11A1_ENST00000370096.3_Missense_Mutation_p.S67Y|COL11A1_ENST00000512756.1_Missense_Mutation_p.S67Y|COL11A1_ENST00000353414.4_Missense_Mutation_p.S67Y	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	67	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGAGCCTTTAGAATTCTTTCT	0.358													20	50					1.22574e-08	1.45102e-08	1	1	0	T	103548435	G	T	103548435	3	4	48	1	0	0	0	0	1	0	0	0	3690	942	33	2	5641	2	COL11A1	1	103548435	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1843244	103548435	145702186	182	4576										
PRPF38B	55119	broad.mit.edu	37	chr1	109238722	109238722	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattttgcctgttatacaaaTtatttaccctgaagttaact	4	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:109238722T>G	ENST00000370021.1	+	4	707	c.70T>G	c.(70-72)Tta>Gta	p.L24V	PRPF38B_ENST00000370025.4_Missense_Mutation_p.L135V|PRPF38B_ENST00000467302.1_3'UTR|PRPF38B_ENST00000370022.5_Missense_Mutation_p.L135V			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	135					mRNA processing|RNA splicing	spliceosomal complex				NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		GTTATACAAATTATTTACCCT	0.363													4	47					0	0	1	0	0	G	109238722	T	G	109238722	3	3	48	1	0	0	0	0	1	0	0	0	12619	1490	52	4	413	4	PRPF38B	1	109238722	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5690287	109238722	140011899	183	4577										
PRPF38B	55119	broad.mit.edu	37	chr1	109242061	109242061	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggatagaagggacagggatCgagaaagagagaaagaaaat	16	2	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:109242061C>T	ENST00000370021.1	+	7	1364	c.727C>T	c.(727-729)Cga>Tga	p.R243*	PRPF38B_ENST00000370025.4_Nonsense_Mutation_p.R354*			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	354					mRNA processing|RNA splicing	spliceosomal complex				NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		ggacagggatcgagaaagaga	0.468													6	48					0	0	1	0	0	T	109242061	C	T	109242061	4	4	48	1	0	0	0	0	0	1	0	0	12619	876	31	1	1082	1	PRPF38B	1	109242061	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3339	109242061	140008560	184	4578										
AKNAD1	254268	broad.mit.edu	37	chr1	109394800	109394800	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgagttctggggtttgttCttttggccaagaattcttat	11	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:109394800C>A	ENST00000370001.3	-	2	755	c.487G>T	c.(487-489)Gaa>Taa	p.E163*	AKNAD1_ENST00000369995.3_Nonsense_Mutation_p.E163*|AKNAD1_ENST00000357393.4_Intron|AKNAD1_ENST00000369994.1_Nonsense_Mutation_p.E163*	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	163										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						GGGGTTTGTTCTTTTGGCCAA	0.408													23	43					1.55469e-16	2.07108e-16	1	1	0	A	109394800	C	A	109394800	4	1	48	1	0	0	0	0	0	1	0	0	461	922	32	2	2083	2	AKNAD1	1	109394800	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	152739	109394800	139855821	185	4579										
WDR47	22911	broad.mit.edu	37	chr1	109556458	109556458	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaccttcaggaataaaaatCttacatgctggggctcatct	7	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:109556458C>A	ENST00000400794.3	-	4	465	c.332G>T	c.(331-333)aGa>aTa	p.R111I	WDR47_ENST00000357672.3_Intron|WDR47_ENST00000369962.3_Intron|WDR47_ENST00000369965.4_Intron|WDR47_ENST00000361054.3_Intron			O94967	WDR47_HUMAN	WD repeat domain 47	109										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GAATAAAAATCTTACATGCTG	0.368													19	33					8.34094e-07	9.42356e-07	1	1	0	A	109556458	C	A	109556458	3	1	48	1	0	0	0	0	1	0	0	0	17359	913	32	2	2499	2	WDR47	1	109556458	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	161658	109556458	139694163	186	4580										
CELSR2	1952	broad.mit.edu	37	chr1	109815829	109815829	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggccccctggccaggagacTttgggaccacagcaaaagag	13	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:109815829T>G	ENST00000271332.3	+	32	8441	c.8380T>G	c.(8380-8382)Ttt>Gtt	p.F2794V	CELSR2_ENST00000498157.1_3'UTR	NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2794					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCCAGGAGACTTTGGGACCAC	0.652													4	70					0	0	1	0	0	G	109815829	T	G	109815829	3	3	48	1	0	0	0	0	1	0	0	0	3244	1609	56	4	8506	4	CELSR2	1	109815829	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	259371	109815829	139434792	187	4581										
GNAT2	2780	broad.mit.edu	37	chr1	110155430	110155430	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagcatcctcctgcagcttCttttctagctccttggacct	6	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:110155430C>A	ENST00000351050.3	-	1	249	c.63G>T	c.(61-63)aaG>aaT	p.K21N		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	21					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		CCTGCAGCTTCTTTTCTAGCT	0.527													42	70					1.67305e-13	2.14637e-13	1	1	0	A	110155430	C	A	110155430	3	1	48	1	0	0	0	0	1	0	0	0	6553	912	32	2	1033	2	GNAT2	1	110155430	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	339601	110155430	139095191	188	4582										
AMPD2	271	broad.mit.edu	37	chr1	110163640	110163640	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggttgcctagacaacatgaGaaatcgtggccagggcctct	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:110163640G>T	ENST00000256578.3	+	1	365	c.5G>T	c.(4-6)aGa>aTa	p.R2I	AMPD2_ENST00000528667.1_Missense_Mutation_p.R2I|AMPD2_ENST00000526301.1_Intron|AMPD2_ENST00000342115.4_Intron	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	2					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GACAACATGAGAAATCGTGGC	0.647													10	14					0.00010058	0.000108553	1	1	0	T	110163640	G	T	110163640	3	4	48	1	0	0	0	0	1	0	0	0	582	942	33	2	21	2	AMPD2	1	110163640	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8210	110163640	139086981	189	4583										
SLC16A4	9122	broad.mit.edu	37	chr1	110921888	110921888	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcctttatctttaataccaGaattgttctcacttttgata	4	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:110921888G>A	ENST00000369779.4	-	6	866	c.617C>T	c.(616-618)tCt>tTt	p.S206F	SLC16A4_ENST00000437429.2_Missense_Mutation_p.S96F|SLC16A4_ENST00000472422.2_Missense_Mutation_p.S158F|SLC16A4_ENST00000369781.4_Intron|SLC16A4_ENST00000541986.1_Missense_Mutation_p.S144F|SLC16A4_ENST00000497687.1_5'UTR	NM_001201547.1|NM_004696.2	NP_001188476.1|NP_004687.1	O15374	MOT5_HUMAN	solute carrier family 16, member 4	206						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(2)|ovary(3)|prostate(1)|stomach(2)	16		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	TTTAATACCAGAATTGTTCTC	0.423													11	33					0	0	1	0	0	A	110921888	G	A	110921888	3	1	48	1	0	0	0	0	1	0	0	0	14464	942	33	3	862	3	SLC16A4	1	110921888	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	758248	110921888	138328733	190	4584										
KCNA10	3744	broad.mit.edu	37	chr1	111060320	111060320	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgccttcagtgtttgcccgaGgatctgcagccccttggagt	12	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:111060320G>T	ENST00000369771.2	-	1	1477	c.1090C>A	c.(1090-1092)Ctc>Atc	p.L364I		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	364						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GTTTGCCCGAGGATCTGCAGC	0.557													53	91					2.0833e-19	2.83573e-19	1	1	0	T	111060320	G	T	111060320	3	4	48	1	0	0	0	0	1	0	0	0	8045	1000	35	5	449	5	KCNA10	1	111060320	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	138432	111060320	138190301	191	4585										
KCNA3	3738	broad.mit.edu	37	chr1	111216263	111216263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccgcatggacgccttcagcGtttgcccgaggatctgcagc	12	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:111216263G>A	ENST00000369769.2	-	1	1392	c.1169C>T	c.(1168-1170)aCg>aTg	p.T390M		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	390				T -> S (in Ref. 5; AAA36425).		voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGCCTTCAGCGTTTGCCCGAG	0.587													50	81					0	0	1	0	0	A	111216263	G	A	111216263	3	1	48	1	0	0	0	0	1	0	0	0	8047	1145	40	1	562	1	KCNA3	1	111216263	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	155943	111216263	138034358	192	4586										
KCNA3	3738	broad.mit.edu	37	chr1	111216610	111216610	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgctgttgccggctgcttcGaatgagtcctgcgacgtcga	14	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:111216610G>A	ENST00000369769.2	-	1	1045	c.822C>T	c.(820-822)ttC>ttT	p.F274F		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	274						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGGCTGCTTCGAATGAGTCCT	0.612													4	91					0	0	1	0	0	A	111216610	G	A	111216610	2	1	48	1	0	0	0	0	0	0	0	1	8047	1049	37	1		1	KCNA3	1	111216610	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	347	111216610	138034011	193	4587										
KCNA3	3738	broad.mit.edu	37	chr1	111216954	111216954	+	Missense_Mutation	SNP	G	G	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccggactgatagtagtagaGgatggcgtcgaagctgggcc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:111216954G>T	ENST00000369769.2	-	1	701	c.478C>A	c.(478-480)Ctc>Atc	p.L160I		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	160						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGTAGTAGAGGATGGCGTCG	0.647													53	102					1.11015e-26	1.57159e-26	1	1	0	T	111216954	G	T	111216954	3	4	48	1	0	0	0	0	1	0	0	0	8047	1000	35	5	1253	5	KCNA3	1	111216954	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	344	111216954	138033667	194	4588	17	2								
KCNA3	3738	broad.mit.edu	37	chr1	111216964	111216964	+	Silent	SNP	G	G	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtagtagaggatggcgtcGaagctgggccggttgcggtc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:111216964G>A	ENST00000369769.2	-	1	691	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	156						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGATGGCGTCGAAGCTGGGCC	0.642													53	107					0	0	1	0	0	A	111216964	G	A	111216964	2	1	48	1	0	0	0	0	0	0	0	1	8047	1049	37	1		1	KCNA3	1	111216964	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10	111216964	138033657	195	4589	17	2								
KCND3	3752	broad.mit.edu	37	chr1	112329633	112329633	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctaaagttggaaacaatcAcagggactggcagggcaatg	14	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:112329633A>C	ENST00000369697.1	-	2	1271	c.1202T>G	c.(1201-1203)gTg>gGg	p.V401G	KCND3_ENST00000302127.4_Missense_Mutation_p.V401G|KCND3_ENST00000315987.2_Missense_Mutation_p.V401G			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	401						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGAAACAATCACAGGGACTGG	0.542													34	41					0	0	1	0	0	C	112329633	A	C	112329633	3	2	48	1	0	0	0	0	1	0	0	0	8063	159	6	4	789	4	KCND3	1	112329633	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1112669	112329633	136920988	196	4590										
WNT2B	7482	broad.mit.edu	37	chr1	113057506	113057506	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccttgcaggtacattgggGcactgggggcacgagtgatc	16	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:113057506G>A	ENST00000369684.4	+	2	678	c.193G>A	c.(193-195)Gca>Aca	p.A65T	WNT2B_ENST00000478360.1_3'UTR|WNT2B_ENST00000369686.4_Missense_Mutation_p.A46T|WNT2B_ENST00000256640.5_5'UTR	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B	65					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACATTGGGGCACTGGGGGC	0.562													38	59					0	0	1	0	0	A	113057506	G	A	113057506	3	1	48	1	0	0	0	0	1	0	0	0	17446	1203	42	3	332	3	WNT2B	1	113057506	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	727873	113057506	136193115	197	4591										
WNT2B	7482	broad.mit.edu	37	chr1	113063068	113063068	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtacggtgcaaggaatgcagAaatactgtggacgtccatac	12	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:113063068A>C	ENST00000369684.4	+	5	1598	c.1113A>C	c.(1111-1113)agA>agC	p.R371S	WNT2B_ENST00000369686.4_Missense_Mutation_p.R352S|WNT2B_ENST00000256640.5_Missense_Mutation_p.R279S	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B	371					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGGAATGCAGAAATACTGTGG	0.532													11	41					0	0	1	0	0	C	113063068	A	C	113063068	3	2	48	1	0	0	0	0	1	0	0	0	17446	243	9	4	1264	4	WNT2B	1	113063068	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5562	113063068	136187553	198	4592										
PTPN22	26191	broad.mit.edu	37	chr1	114372580	114372580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaccacttacaatcttcatCggcaagaaagaaggactcta	6	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:114372580C>T	ENST00000359785.5	-	17	2260	c.2125G>A	c.(2125-2127)Gat>Aat	p.D709N	PTPN22_ENST00000538253.1_Missense_Mutation_p.D465N|PTPN22_ENST00000525799.1_Missense_Mutation_p.D582N|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000528414.1_Missense_Mutation_p.D654N|PTPN22_ENST00000420377.2_Missense_Mutation_p.D709N	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	709					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAATCTTCATCGGCAAGAAAG	0.353													9	20					0	0	1	0	0	T	114372580	C	T	114372580	3	4	48	1	0	0	0	0	1	0	0	0	12838	884	31	1	318	1	PTPN22	1	114372580	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1309512	114372580	134878041	199	4593										
AP4B1	10717	broad.mit.edu	37	chr1	114438410	114438410	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggatgaagttttaggaagCtctgggtcacaacgctctgc	12	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:114438410C>T	ENST00000369569.1	-	9	2041	c.1761G>A	c.(1759-1761)gaG>gaA	p.E587E	AP4B1_ENST00000256658.4_Silent_p.E587E|AP4B1-AS1_ENST00000419536.1_RNA|AP4B1_ENST00000369567.1_Silent_p.E419E|AP4B1_ENST00000462591.1_5'UTR	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	587					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTTAGGAAGCTCTGGGTCAC	0.453													14	31					0	0	1	0	0	T	114438410	C	T	114438410	2	4	48	1	0	0	0	0	0	0	0	1	747	796	28	3		3	AP4B1	1	114438410	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	65830	114438410	134812211	200	4594										
DCLRE1B	64858	broad.mit.edu	37	chr1	114450763	114450763	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcccgacaagaagctgcccAccagattgtccagctcattc	7	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:114450763A>G	ENST00000369563.3	+	3	934	c.488A>G	c.(487-489)cAc>cGc	p.H163R	DCLRE1B_ENST00000466480.1_3'UTR	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	163					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAGCTGCCCACCAGATTGTC	0.458								Other identified genes with known or suspected DNA repair function					5	108					0	0	1	0	0	G	114450763	A	G	114450763	3	3	48	1	0	0	0	0	1	0	0	0	4318	159	6	4	498	4	DCLRE1B	1	114450763	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	12353	114450763	134799858	201	4595										
TRIM33	51592	broad.mit.edu	37	chr1	114964082	114964082	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgggtggaatatctggcagCgatggaaggttttctggatt	15	4	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:114964082C>T	ENST00000358465.2	-	11	2120	c.2037G>A	c.(2035-2037)tcG>tcA	p.S679S	TRIM33_ENST00000369543.2_Silent_p.S679S|TRIM33_ENST00000450349.2_Silent_p.S287S	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	679					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TATCTGGCAGCGATGGAAGGT	0.403			T	RET	papillary thyroid								21	64					0	0	1	0	0	T	114964082	C	T	114964082	2	4	48	1	0	0	0	0	0	0	0	1	16567	755	27	1		1	TRIM33	1	114964082	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	513319	114964082	134286539	202	4596										
NRAS	4893	broad.mit.edu	37	chr1	115256514	115256514	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatgtattggtctctcatgGcactgtactcttcttgtcca	7	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:115256514G>A	ENST00000369535.4	-	3	450	c.197C>T	c.(196-198)gCc>gTc	p.A66V		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	66					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity			NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCTCTCATGGCACTGTACTC	0.443		50	Mis		"melanoma, MM, AML, thyroid"				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			39	73					0	0	1	0	0	A	115256514	G	A	115256514	3	1	48	1	0	0	0	0	1	0	0	0	10687	1203	42	3	384	3	NRAS	1	115256514	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	292432	115256514	133994107	203	4597										
SYCP1	6847	broad.mit.edu	37	chr1	115487508	115487508	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataggttgagaaagcaaaaGtaatagctgatgaagcagta	12	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:115487508G>T	ENST00000369522.3	+	25	2299	c.2059G>T	c.(2059-2061)Gta>Tta	p.V687L	SYCP1_ENST00000369518.1_Missense_Mutation_p.V687L	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	687					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAAGCAAAAGTAATAGCTGA	0.264													6	18					3.59834e-05	3.93264e-05	1	1	0	T	115487508	G	T	115487508	3	4	48	1	0	0	0	0	1	0	0	0	15487	1029	36	5	2153	5	SYCP1	1	115487508	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	230994	115487508	133763113	204	4598										
IGSF3	3321	broad.mit.edu	37	chr1	117150700	117150700	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctggcggaggtggtagatCttcagcacaaagacactgtc	12	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:117150700C>A	ENST00000369486.3	-	5	1851	c.1086G>T	c.(1084-1086)aaG>aaT	p.K362N	IGSF3_ENST00000369483.1_Missense_Mutation_p.K362N|IGSF3_ENST00000318837.6_Missense_Mutation_p.K362N	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	362	Ig-like C2-type 3.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGTGGTAGATCTTCAGCACAA	0.542													31	92					7.61001e-30	1.08524e-29	1	1	0	A	117150700	C	A	117150700	3	1	48	1	0	0	0	0	1	0	0	0	7644	912	32	2	2590	2	IGSF3	1	117150700	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1663192	117150700	132099921	205	4599										
CD101	9398	broad.mit.edu	37	chr1	117552698	117552698	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatatacgcagcgggtgcgAagcggagacgtctacgtgga	16	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:117552698A>G	ENST00000256652.4	+	2	328	c.270A>G	c.(268-270)cgA>cgG	p.R90R	CD101_ENST00000369470.1_Silent_p.R90R	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	90	Ig-like C2-type 1.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	p.R90R(1)		NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGCGGGTGCGAAGCGGAGACG	0.532													22	28					0	0	1	0	0	G	117552698	A	G	117552698	2	3	48	1	0	0	0	0	0	0	0	1	2984	233	9	4		4	CD101	1	117552698	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	401998	117552698	131697923	206	4600										
CD101	9398	broad.mit.edu	37	chr1	117554504	117554504	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgttctgtgaggcaacgGaatggattcaggatccagat	13	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:117554504G>A	ENST00000256652.4	+	3	815	c.757G>A	c.(757-759)Gaa>Aaa	p.E253K	CD101_ENST00000369470.1_Missense_Mutation_p.E253K	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	253	Ig-like C2-type 2.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGAGGCAACGGAATGGATTCA	0.493													11	25					0	0	1	0	0	A	117554504	G	A	117554504	3	1	48	1	0	0	0	0	1	0	0	0	2984	1175	41	3	767	3	CD101	1	117554504	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1806	117554504	131696117	207	4601										
MAN1A2	10905	broad.mit.edu	37	chr1	118042105	118042105	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctccgtccagaagtaattGaaacctattggtacctatgg	8	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:118042105G>T	ENST00000356554.3	+	11	2341	c.1606G>T	c.(1606-1608)Gaa>Taa	p.E536*		NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	536					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AGAAGTAATTGAAACCTATTG	0.453													14	29					0.0202918	0.0207569	1	1	0	T	118042105	G	T	118042105	4	4	48	1	0	0	0	0	0	1	0	0	9260	1291	45	2	1648	2	MAN1A2	1	118042105	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	487601	118042105	131208516	208	4602										
MAN1A2	10905	broad.mit.edu	37	chr1	118045593	118045593	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcttgctgaaacattaaaGtaagtatatagctttaaaaa	5	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:118045593G>T	ENST00000356554.3	+	12	2528		c.e12+1			NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2						N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AAACATTAAAGTAAGTATATA	0.333													8	7					5.18039e-06	5.75679e-06	1	1	0	T	118045593	G	T	118045593	5	4	48	1	0	0	0	0	0	0	1	0	9260	1043	36	5	1840	5	MAN1A2	1	118045593	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3488	118045593	131205028	209	4603										
SPAG17	200162	broad.mit.edu	37	chr1	118530745	118530745	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctccatgtcttttcaaaGaaatctttaccaaatgtgtc	4	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:118530745G>T	ENST00000336338.5	-	39	5669	c.5604C>A	c.(5602-5604)ttC>ttA	p.F1868L		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1868						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCTTTTCAAAGAAATCTTTAC	0.363													4	10					0.150653	0.151842	1	1	0	T	118530745	G	T	118530745	3	4	48	1	0	0	0	0	1	0	0	0	15034	933	33	2	1107	2	SPAG17	1	118530745	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	485152	118530745	130719876	210	4604										
HSD3B2	3284	broad.mit.edu	37	chr1	119964880	119964880	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaagtgtccgaggtcaattCtattacatctcagatgacac	7	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:119964880C>A	ENST00000543831.1	+	4	1005	c.756C>A	c.(754-756)ttC>ttA	p.F252L	HSD3B2_ENST00000369416.3_Missense_Mutation_p.F252L	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	252					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GAGGTCAATTCTATTACATCT	0.527													31	51					5.60225e-13	7.13348e-13	1	1	0	A	119964880	C	A	119964880	3	1	48	1	0	0	0	0	1	0	0	0	7431	912	32	2	766	2	HSD3B2	1	119964880	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1434135	119964880	129285741	211	4605										
ADAM30	11085	broad.mit.edu	37	chr1	120437706	120437706	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgatctttctgacactcctcTgtggaaccacagtcacattc	6	14	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:120437706T>C	ENST00000369400.1	-	1	1412	c.1254A>G	c.(1252-1254)acA>acG	p.T418T		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	418	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GACACTCCTCTGTGGAACCAC	0.433													9	134					0	0	1	0	0	C	120437706	T	C	120437706	2	2	48	1	0	0	0	0	0	0	0	1	247	1567	55	4		4	ADAM30	1	120437706	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	472826	120437706	128812915	212	4606										
FAM72B	653820	broad.mit.edu	37	chr1	120846067	120846067	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgcaacaacggacacttCtggatgtttcacagccaggc	9	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:120846067C>A	ENST00000369390.3	+	3	1132	c.303C>A	c.(301-303)ttC>ttA	p.F101L	FAM72B_ENST00000355228.4_Missense_Mutation_p.F61L|FAM72B_ENST00000471903.2_3'UTR	NM_001100910.1	NP_001094380.1	Q86X60	FA72B_HUMAN	family with sequence similarity 72, member B	101										large_intestine(1)|lung(2)	3	all_neural(166;0.181)	all_lung(203;7.27e-05)|Lung NSC(69;0.000389)|all_epithelial(167;0.068)		Lung(183;0.0327)|LUSC - Lung squamous cell carcinoma(189;0.19)		ACGGACACTTCTGGATGTTTC	0.378													82	128					1.69331e-39	2.44455e-39	1	1	0	A	120846067	C	A	120846067	3	1	48	1	0	0	0	0	1	0	0	0	5649	912	32	2	313	2	FAM72B	1	120846067	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	408361	120846067	128404554	213	4607										
FCGR1B	2210	broad.mit.edu	37	chr1	120927161	120927161	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggccccctggggctccttCcggtgcaccccttcctgcag	12	18	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:120927161C>T	ENST00000369384.4	-	5	861	c.819G>A	c.(817-819)cgG>cgA	p.R273R	RP11-439A17.9_ENST00000457996.1_RNA|RP11-439A17.10_ENST00000426275.1_RNA|FCGR1B_ENST00000369383.4_Silent_p.R181R	NM_001017986.3	NP_001017986.1	Q92637	FCGRB_HUMAN	Fc fragment of IgG, high affinity Ib, receptor (CD64)	273					interferon-gamma-mediated signaling pathway	integral to membrane|plasma membrane	IgG binding|immunoglobulin receptor activity			breast(1)|endometrium(1)|lung(2)	4	all_neural(166;0.181)	all_lung(203;7.27e-05)|Lung NSC(69;0.000389)|all_epithelial(167;0.068)		Lung(183;0.0327)|LUSC - Lung squamous cell carcinoma(189;0.19)		GGGGCTCCTTCCGGTGCACCC	0.542													16	39					0	0	1	0	0	T	120927161	C	T	120927161	2	4	48	1	0	0	0	0	0	0	0	1	5812	842	30	3		3	FCGR1B	1	120927161	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	81094	120927161	128323460	214	4608										
PDE4DIP	9659	broad.mit.edu	37	chr1	144879545	144879545	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaggaccatttccttgaggCtgttgtgctcctcacactct	8	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:144879545C>T	ENST00000369359.4	-	30	4351	c.4313G>A	c.(4312-4314)aGc>aAc	p.S1438N	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1302N|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1302N|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S1258N|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1438N			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1302					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCCTTGAGGCTGTTGTGCTC	0.527			T	PDGFRB	MPD								10	86					0	0	1	0	0	T	144879545	C	T	144879545	3	4	48	1	0	0	0	0	1	0	0	0	11689	797	28	3	3207	3	PDE4DIP	1	144879545	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23952384	144879545	104371076	215	4609										
PDE4DIP	9659	broad.mit.edu	37	chr1	145075802	145075802	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgagcccggcgggacgcgcGacagcagcagccaaagtcgc	16	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:145075802G>A	ENST00000369359.4	-	1	99	c.61C>T	c.(61-63)Cgc>Tgc	p.R21C	PDE4DIP_ENST00000369348.3_Missense_Mutation_p.R21C|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R21C|PDE4DIP_ENST00000369345.4_Missense_Mutation_p.R21C			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGGGACGCGCGACAGCAGCAG	0.697			T	PDGFRB	MPD								8	117					0	0	1	0	0	A	145075802	G	A	145075802	3	1	48	1	0	0	0	0	1	0	0	0	11689	1058	37	1	8751	1	PDE4DIP	1	145075802	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	196257	145075802	104174819	216	4610										
ANKRD35	148741	broad.mit.edu	37	chr1	145562646	145562646	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggccccagcatccccccaAgtggccgctctggagcaaga	11	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:145562646A>G	ENST00000355594.4	+	10	2421	c.2334A>G	c.(2332-2334)caA>caG	p.Q778Q		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	778										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATCCCCCCAAGTGGCCGCTC	0.627													7	5					0	0	1	0	0	G	145562646	A	G	145562646	2	3	48	1	0	0	0	0	0	0	0	1	659	69	3	4		4	ANKRD35	1	145562646	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	486844	145562646	103687975	217	4611										
GPR89A	653519	broad.mit.edu	37	chr1	145765393	145765393	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgtgctaatagcaggacAatgacattggaggacttact	10	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:145765393A>G	ENST00000313835.9	-	13	1280	c.1137T>C	c.(1135-1137)atT>atC	p.I379I	GPR89A_ENST00000462900.2_Silent_p.I354I|GPR89A_ENST00000534502.1_Silent_p.I354I|GPR89A_ENST00000454423.3_Silent_p.I259I			B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A	379				I -> T (in Ref. 6; BAD96943).	intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity			breast(1)|large_intestine(3)|lung(1)|skin(1)	6	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			ATAGCAGGACAATGACATTGG	0.338													37	165					0	0	1	0	0	G	145765393	A	G	145765393	2	3	48	1	0	0	0	0	0	0	0	1	6757	126	5	4		4	GPR89A	1	145765393	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	202747	145765393	103485228	218	4612										
OTUD7B	56957	broad.mit.edu	37	chr1	149943146	149943146	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgacgtagctgttcaaaaTcactgagggcggcattcaca	10	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:149943146T>G	ENST00000369135.3	-	3	413	c.119A>C	c.(118-120)gAt>gCt	p.D40A	OTUD7B_ENST00000479905.1_5'UTR	NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	40					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CTGTTCAAAATCACTGAGGGC	0.473													5	64					0	0	1	0	0	G	149943146	T	G	149943146	3	3	48	1	0	0	0	0	1	0	0	0	11365	1435	50	4	2452	4	OTUD7B	1	149943146	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4177753	149943146	99307475	219	4613										
ANP32E	81611	broad.mit.edu	37	chr1	150193064	150193064	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctcgaagacctccttcttCttaaagagtggaaagaaaaa	7	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:150193064C>A	ENST00000314136.8	-	7	1106		c.e7-1		ANP32E_ENST00000369119.3_Splice_Site|ANP32E_ENST00000369115.2_Splice_Site|ANP32E_ENST00000533654.1_Splice_Site|ANP32E_ENST00000436748.2_Splice_Site|ANP32E_ENST00000369114.5_Intron|ANP32E_ENST00000369116.4_Splice_Site	NM_001136478.2|NM_030920.3	NP_001129950.1|NP_112182.1	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E							cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity			breast(3)|endometrium(3)|lung(7)|skin(1)|urinary_tract(1)	15	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTCCTTCTTCTTAAAGAGTG	0.383													42	95					7.63091e-17	1.01921e-16	1	1	0	A	150193064	C	A	150193064	5	1	48	1	0	0	0	0	0	0	1	0	703	927	32	2	74	2	ANP32E	1	150193064	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	249918	150193064	99057557	220	4614										
C1orf54	79630	broad.mit.edu	37	chr1	150248154	150248154	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttctcctctgcagatgaCtttagtgcagatttcaccat	6	11	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:150248154C>A	ENST00000369102.1	+	5	905	c.135C>A	c.(133-135)gaC>gaA	p.D45E	C1orf54_ENST00000369099.3_Missense_Mutation_p.D45E|C1orf54_ENST00000369098.3_Missense_Mutation_p.D45E			Q8WWF1	CA054_HUMAN	chromosome 1 open reading frame 54	45						extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGCAGATGACTTTAGTGCAG	0.333													7	15					0.00307968	0.00320271	1	1	0	A	150248154	C	A	150248154	3	1	48	1	0	0	0	0	1	0	0	0	2060	564	20	5	145	5	C1orf54	1	150248154	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	55090	150248154	99002467	221	4615										
HORMAD1	84072	broad.mit.edu	37	chr1	150672634	150672634	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttccgattttctttggaaGattttactggttgatttcca	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:150672634G>T	ENST00000368993.2	-	14	1163	c.1058C>A	c.(1057-1059)tCt>tAt	p.S353Y	HORMAD1_ENST00000322343.7_Missense_Mutation_p.S346Y|HORMAD1_ENST00000361824.2_Missense_Mutation_p.S353Y|HORMAD1_ENST00000368995.4_Missense_Mutation_p.S273Y			Q86X24	HORM1_HUMAN	HORMA domain containing 1	353					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTTTGGAAGATTTTACTGG	0.323													12	23					0.105934	0.10725	1	1	0	T	150672634	G	T	150672634	3	4	48	1	0	0	0	0	1	0	0	0	7326	942	33	2	134	2	HORMAD1	1	150672634	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	424480	150672634	98577987	222	4616										
ANXA9	8416	broad.mit.edu	37	chr1	150959104	150959104	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgacagctactctggaatCattgactataatctggcaga	9	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:150959104C>A	ENST00000368947.4	+	9	1055	c.579C>A	c.(577-579)atC>atA	p.I193I		NM_003568.2	NP_003559.2	O76027	ANXA9_HUMAN	annexin A9	193					cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(4)|skin(2)	8	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACTCTGGAATCATTGACTATA	0.502													36	59					2.40579e-17	3.22781e-17	1	1	0	A	150959104	C	A	150959104	2	1	48	1	0	0	0	0	0	0	0	1	721	816	29	2		2	ANXA9	1	150959104	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	286470	150959104	98291517	223	4617										
FAM63A	55793	broad.mit.edu	37	chr1	150973025	150973025	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaaaatcagagacgcctgTgaatcgcacattgacatcca	7	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:150973025T>C	ENST00000361936.5	-	6	1597	c.643A>G	c.(643-645)Aca>Gca	p.T215A	FAM63A_ENST00000470877.1_Intron|FAM63A_ENST00000312210.5_Missense_Mutation_p.T73A|FAM63A_ENST00000493834.2_Missense_Mutation_p.T120A|FAM63A_ENST00000361738.6_Missense_Mutation_p.T263A	NM_018379.4	NP_060849.2	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	215							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGACGCCTGTGAATCGCACA	0.483													37	64					0	0	1	0	0	C	150973025	T	C	150973025	3	2	48	1	0	0	0	0	1	0	0	0	5630	1696	59	4	790	4	FAM63A	1	150973025	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	13921	150973025	98277596	224	4618										
SEMA6C	10500	broad.mit.edu	37	chr1	151108986	151108986	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatccagactcctctgctcCttgaacttgccctcaaaccc	4	19	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:151108986C>A	ENST00000341697.3	-	12	2735	c.1044G>T	c.(1042-1044)aaG>aaT	p.K348N				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	348	Sema.					integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCTCTGCTCCTTGAACTTGC	0.567													77	145					5.02462e-34	7.21672e-34	1	1	0	A	151108986	C	A	151108986	3	1	48	1	0	0	0	0	1	0	0	0	14094	680	24	5	1880	5	SEMA6C	1	151108986	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	135961	151108986	98141635	225	4619										
VPS72	6944	broad.mit.edu	37	chr1	151158378	151158378	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaaagtcagagtccacttCgtcctctgtgtctgactggt	10	11	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:151158378C>T	ENST00000354473.4	-	2	202	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	VPS72_ENST00000496809.1_5'UTR	NM_001271087.1|NM_005997.1	NP_001258016.1|NP_005988.1	Q15906	VPS72_HUMAN	vacuolar protein sorting 72 homolog (S. cerevisiae)	56	Asp/Glu-rich (acidic).				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	14	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGTCCACTTCGTCCTCTGTG	0.517													17	57					0	0	1	0	0	T	151158378	C	T	151158378	3	4	48	1	0	0	0	0	1	0	0	0	17276	893	31	1	948	1	VPS72	1	151158378	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	49392	151158378	98092243	226	4620										
SNX27	81609	broad.mit.edu	37	chr1	151611416	151611416	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaggtggtggacctgattCgagcaggcgagaaggaattg	17	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:151611416C>T	ENST00000368843.3	+	2	484	c.364C>T	c.(364-366)Cga>Tga	p.R122*	SNX27_ENST00000368838.1_Nonsense_Mutation_p.R29*|SNX27_ENST00000458013.2_Nonsense_Mutation_p.R122*	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	122	PDZ.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGACCTGATTCGAGCAGGCGA	0.483													27	36					0	0	1	0	0	T	151611416	C	T	151611416	4	4	48	1	0	0	0	0	0	1	0	0	14950	876	31	1	370	1	SNX27	1	151611416	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	453038	151611416	97639205	227	4621										
SNX27	81609	broad.mit.edu	37	chr1	151633298	151633298	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaatacgagtaattggtgAgagtgacatcatgcaggaat	11	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:151633298A>C	ENST00000368843.3	+	4	881	c.761A>C	c.(760-762)gAg>gCg	p.E254A	SNX27_ENST00000368838.1_Missense_Mutation_p.E161A|SNX27_ENST00000458013.2_Missense_Mutation_p.E254A	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	254	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTAATTGGTGAGAGTGACATC	0.348													9	50					0	0	1	0	0	C	151633298	A	C	151633298	3	2	48	1	0	0	0	0	1	0	0	0	14950	304	11	4	775	4	SNX27	1	151633298	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	21882	151633298	97617323	228	4622										
TCHHL1	126637	broad.mit.edu	37	chr1	152057988	152057988	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctgaattgtcctcatctaGactttctaacagagtattct	7	9	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152057988G>A	ENST00000368806.1	-	3	2234	c.2170C>T	c.(2170-2172)Cta>Tta	p.L724L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	724							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCCTCATCTAGACTTTCTAAC	0.448													28	70					0	0	1	0	0	A	152057988	G	A	152057988	2	1	48	1	0	0	0	0	0	0	0	1	15760	933	33	3		3	TCHHL1	1	152057988	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	424690	152057988	97192633	229	4623										
TCHH	7062	broad.mit.edu	37	chr1	152085512	152085512	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccattactgtcaagatccaGaagttccaggatcagatcta	7	11	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152085512G>T	ENST00000368804.1	-	2	180	c.181C>A	c.(181-183)Ctg>Atg	p.L61M		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	61	EF-hand 2.|S-100-like.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAAGATCCAGAAGTTCCAGG	0.408													16	24					2.23348e-06	2.50077e-06	1	1	0	T	152085512	G	T	152085512	3	4	48	1	0	0	0	0	1	0	0	0	15759	933	33	2	5654	2	TCHH	1	152085512	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	27524	152085512	97165109	230	4624										
TCHH	7062	broad.mit.edu	37	chr1	152086435	152086435	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacccgaagcacagctccaAattccctttcaaggaggttc	7	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152086435A>C	ENST00000368804.1	-	1	121	c.122T>G	c.(121-123)tTt>tGt	p.F41C		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	41	EF-hand 1.|S-100-like.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACAGCTCCAAATTCCCTTTC	0.403													9	54					0	0	1	0	0	C	152086435	A	C	152086435	3	2	48	1	0	0	0	0	1	0	0	0	15759	14	1	4	5717	4	TCHH	1	152086435	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	923	152086435	97164186	231	4625										
HRNR	388697	broad.mit.edu	37	chr1	152193031	152193031	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatgcttactatagccagaGgactgtcctgagccagactc	9	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152193031G>T	ENST00000368801.2	-	3	1149	c.1074C>A	c.(1072-1074)tcC>tcA	p.S358S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	358					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATAGCCAGAGGACTGTCCTG	0.547													53	139					7.77372e-23	1.08358e-22	1	1	0	T	152193031	G	T	152193031	2	4	48	1	0	0	0	0	0	0	0	1	7399	987	35	5		5	HRNR	1	152193031	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	106596	152193031	97057590	232	4626										
FLG	2312	broad.mit.edu	37	chr1	152275493	152275493	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgccctcagattgataatGataagaactagaactgtgag	10	6	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152275493G>T	ENST00000368799.1	-	3	11904	c.11869C>A	c.(11869-11871)Cat>Aat	p.H3957N	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3957					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGATAATGATAAGAACTA	0.428									Ichthyosis				38	50					6.70999e-13	8.51699e-13	1	1	0	T	152275493	G	T	152275493	3	4	48	1	0	0	0	0	1	0	0	0	5954	1290	45	2	320	2	FLG	1	152275493	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	82462	152275493	96975128	233	4627										
FLG	2312	broad.mit.edu	37	chr1	152283914	152283914	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagtgcctggagctgtctcGtgcctgctcgtggtgggatc	16	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152283914G>A	ENST00000368799.1	-	3	3483	c.3448C>T	c.(3448-3450)Cga>Tga	p.R1150*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1150	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTGTCTCGTGCCTGCTCG	0.597									Ichthyosis				7	488					0	0	1	0	0	A	152283914	G	A	152283914	4	1	48	1	0	0	0	0	0	1	0	0	5954	1153	40	1	8741	1	FLG	1	152283914	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8421	152283914	96966707	234	4628										
FLG2	388698	broad.mit.edu	37	chr1	152329831	152329831	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagttccccttgagtgcccaGaactatatccatgctcctct	6	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152329831G>T	ENST00000388718.5	-	3	503	c.431C>A	c.(430-432)tCt>tAt	p.S144Y	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	144	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGTGCCCAGAACTATATCC	0.463													53	108					6.56871e-35	9.43686e-35	1	1	0	T	152329831	G	T	152329831	3	4	48	1	0	0	0	0	1	0	0	0	5955	942	33	2	6748	2	FLG2	1	152329831	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	45917	152329831	96920790	235	4629										
KPRP	448834	broad.mit.edu	37	chr1	152733586	152733586	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctggggcccaaatccagttCcatacccaggagacctaggc	11	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152733586C>A	ENST00000368773.1	+	2	1580	c.1522C>A	c.(1522-1524)Cca>Aca	p.P508T	KPRP_ENST00000606109.1_Missense_Mutation_p.P508T	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	508	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAATCCAGTTCCATACCCAGG	0.632													28	60					2.41591e-17	3.2383e-17	1	1	0	A	152733586	C	A	152733586	3	1	48	1	0	0	0	0	1	0	0	0	8478	855	30	2	1524	2	KPRP	1	152733586	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	403755	152733586	96517035	236	4630										
LCE1E	353135	broad.mit.edu	37	chr1	152759805	152759805	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcagagccagcagcagtgCcagccccctcccaagtgcac	10	18	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:152759805C>T	ENST00000368770.3	+	2	83	c.30C>T	c.(28-30)tgC>tgT	p.C10C	LCE1E_ENST00000368771.1_Silent_p.C10C	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	10	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCAGCAGTGCCAGCCCCctc	0.597													6	229					0	0	1	0	0	T	152759805	C	T	152759805	2	4	48	1	0	0	0	0	0	0	0	1	8701	747	26	3		3	LCE1E	1	152759805	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	26219	152759805	96490816	237	4631										
SPRR2D	6703	broad.mit.edu	37	chr1	153012694	153012694	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactgctgaggtgggcagggCtgtggacactttggtgatgg	18	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:153012694C>T	ENST00000368757.1	-	2	409	c.129G>A	c.(127-129)caG>caA	p.Q43Q	SPRR2D_ENST00000368756.1_Silent_p.Q43Q|SPRR2D_ENST00000368758.3_Silent_p.Q43Q|SPRR2D_ENST00000360379.3_Silent_p.Q43Q			P22532	SPR2D_HUMAN	small proline-rich protein 2D	43	3 X 9 AA tandem repeats of P-K-C-P-[EQ]- P-C-P-[PS].				keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTGGGCAGGGCTGTGGACACT	0.617													25	176					0	0	1	0	0	T	153012694	C	T	153012694	2	4	48	1	0	0	0	0	0	0	0	1	15154	796	28	3		3	SPRR2D	1	153012694	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	252889	153012694	96237927	238	4632										
SNAPIN	23557	broad.mit.edu	37	chr1	153632005	153632005	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctacttaatgcccggcgacGcgttgtcttggttaacaaca	10	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:153632005G>A	ENST00000368685.5	+	3	362	c.272G>A	c.(271-273)cGc>cAc	p.R91H	SNAPIN_ENST00000478558.1_3'UTR	NM_012437.5	NP_036569.1	O95295	SNAPN_HUMAN	SNAP-associated protein	91					intracellular protein transport|synaptic vesicle exocytosis	BLOC-1 complex|cell junction|perinuclear region of cytoplasm|synaptic vesicle membrane|synaptosome	SNARE binding	p.R91L(1)		lung(3)	3	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCCGGCGACGCGTTGTCTTG	0.443													26	47					0	0	1	0	0	A	153632005	G	A	153632005	3	1	48	1	0	0	0	0	1	0	0	0	14892	1087	38	1	282	1	SNAPIN	1	153632005	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	619311	153632005	95618616	239	4633										
NUP210L	91181	broad.mit.edu	37	chr1	154098814	154098814	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctacctggtaaatgatggaGgtcagggatgcatttattac	11	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:154098814G>T	ENST00000368559.3	-	10	1382	c.1311C>A	c.(1309-1311)acC>acA	p.T437T	NUP210L_ENST00000271854.3_Silent_p.T437T	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	437						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AAATGATGGAGGTCAGGGATG	0.393													21	64					7.45023e-12	9.31775e-12	1	1	0	T	154098814	G	T	154098814	2	4	48	1	0	0	0	0	0	0	0	1	10808	987	35	5		5	NUP210L	1	154098814	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	466809	154098814	95151807	240	4634										
KCNN3	3782	broad.mit.edu	37	chr1	154841560	154841560	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatcaccataacaacaattCcaaacatcccaaaaatcaga	1	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:154841560C>A	ENST00000271915.3	-	1	1196	c.881G>T	c.(880-882)gGa>gTa	p.G294V		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	299						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			AACAACAATTCCAAACATCCC	0.433													39	100					6.33695e-27	8.97322e-27	1	1	0	A	154841560	C	A	154841560	3	1	48	1	0	0	0	0	1	0	0	0	8123	855	30	2	1368	2	KCNN3	1	154841560	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	742746	154841560	94409061	241	4635										
ADAM15	8751	broad.mit.edu	37	chr1	155023920	155023920	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgcgggcagccctctgcctTcctggccgctcccaaatata	10	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:155023920T>C	ENST00000356955.2	+	1	159	c.58T>C	c.(58-60)Tcc>Ccc	p.S20P	ADAM15_ENST00000368413.1_Missense_Mutation_p.S20P|ADAM15_ENST00000531455.1_Missense_Mutation_p.S20P|ADAM15_ENST00000368412.3_Missense_Mutation_p.S20P|ADAM15_ENST00000447332.3_Missense_Mutation_p.S20P|ADAM15_ENST00000359280.4_Missense_Mutation_p.S20P|ADAM15_ENST00000368410.2_Missense_Mutation_p.S20P|ADAM15_ENST00000271836.6_Missense_Mutation_p.S20P|ADAM15_ENST00000360674.4_Missense_Mutation_p.S20P|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000355956.2_Missense_Mutation_p.S20P|ADAM15_ENST00000449910.2_Missense_Mutation_p.S20P	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	20					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCCTCTGCCTTCCTGGCCGCT	0.701													5	7					0	0	1	0	0	C	155023920	T	C	155023920	3	2	48	1	0	0	0	0	1	0	0	0	236	1783	62	4	60	4	ADAM15	1	155023920	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	182360	155023920	94226701	242	4636										
HCN3	57657	broad.mit.edu	37	chr1	155252476	155252476	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcttctatccctgtggatTacatcttcctagtggtggag	9	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:155252476T>G	ENST00000368358.3	+	2	561	c.553T>G	c.(553-555)Tac>Gac	p.Y185D	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	185						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCCTGTGGATTACATCTTCCT	0.597													22	54					0	0	1	0	0	G	155252476	T	G	155252476	3	3	48	1	0	0	0	0	1	0	0	0	7038	1754	61	4	559	4	HCN3	1	155252476	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	228556	155252476	93998145	243	4637										
YY1AP1	55249	broad.mit.edu	37	chr1	155631027	155631027	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcattagacgattaaggaAgtccttgatattctctcaga	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:155631027A>C	ENST00000405763.3	-	9	1491	c.1481T>G	c.(1480-1482)cTt>cGt	p.L494R	YY1AP1_ENST00000347088.5_Intron|YY1AP1_ENST00000355499.4_Intron|YY1AP1_ENST00000407221.1_Intron|YY1AP1_ENST00000404643.1_Intron|YY1AP1_ENST00000359205.5_Intron|YY1AP1_ENST00000368340.5_Intron|YY1AP1_ENST00000311573.5_Intron|YY1AP1_ENST00000368330.2_Intron|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000535662.1_Intron|YY1AP1_ENST00000368339.5_Intron|YY1AP1_ENST00000361831.5_Intron|YY1AP1_ENST00000295566.4_Intron|MSTO1_ENST00000538143.1_Intron					YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CGATTAAGGAAGTCCTTGATA	0.453													15	30					0	0	1	0	0	C	155631027	A	C	155631027	3	2	48	1	0	0	0	0	1	0	0	0	17567	87	3	4		4	YY1AP1	1	155631027	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	378551	155631027	93619594	244	4638										
SMG5	23381	broad.mit.edu	37	chr1	156222291	156222291	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagcaaatccaggccatcGatcactggtgggcaaggtag	12	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:156222291G>A	ENST00000361813.5	-	19	2811	c.2667C>T	c.(2665-2667)atC>atT	p.I889I	SMG5_ENST00000368267.4_Intron	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	889	PINc.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					CCAGGCCATCGATCACTGGTG	0.527													15	28					0	0	1	0	0	A	156222291	G	A	156222291	2	1	48	1	0	0	0	0	0	0	0	1	14849	1048	37	1		1	SMG5	1	156222291	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	591264	156222291	93028330	245	4639										
GPATCH4	54865	broad.mit.edu	37	chr1	156565382	156565382	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacctttccttcttgatgtcGccttttcttcttcttgcttt	5	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:156565382G>A	ENST00000368232.4	-	8	868	c.736C>T	c.(736-738)Cga>Tga	p.R246*	GPATCH4_ENST00000438976.2_Nonsense_Mutation_p.R251*	NM_015590.3|NM_182679.2	NP_056405.2|NP_872620.1	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4	246						intracellular	nucleic acid binding			autonomic_ganglia(1)|breast(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(3)|stomach(1)	17	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCTTGATGTCGCCTTTTCTTC	0.458													5	195					0	0	1	0	0	A	156565382	G	A	156565382	4	1	48	1	0	0	0	0	0	1	0	0	6632	1095	38	1	380	1	GPATCH4	1	156565382	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	343091	156565382	92685239	246	4640										
NES	10763	broad.mit.edu	37	chr1	156642319	156642319	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagagtcttcagtgactctTgaatctcctctcccagagac	7	14	5	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:156642319T>C	ENST00000368223.3	-	4	1793	c.1661A>G	c.(1660-1662)cAa>cGa	p.Q554R		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	554	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGTGACTCTTGAATCTCCTC	0.433													22	33					0	0	1	0	0	C	156642319	T	C	156642319	3	2	48	1	0	0	0	0	1	0	0	0	10383	1812	63	4	3208	4	NES	1	156642319	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	76937	156642319	92608302	247	4641										
ISG20L2	81875	broad.mit.edu	37	chr1	156697363	156697363	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcctccgcttcttgacaaAatttcggtgcttggcatttc	9	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:156697363A>C	ENST00000313146.6	-	1	864	c.82T>G	c.(82-84)Ttt>Gtt	p.F28V	ISG20L2_ENST00000368219.1_Missense_Mutation_p.F28V	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	28					ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTCTTGACAAAATTTCGGTGC	0.468													46	61					0	0	1	0	0	C	156697363	A	C	156697363	3	2	48	1	0	0	0	0	1	0	0	0	7898	14	1	4	991	4	ISG20L2	1	156697363	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	55044	156697363	92553258	248	4642										
ARHGEF11	9826	broad.mit.edu	37	chr1	156928929	156928929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttcgctgttccgcaggcGcgagtctgtagtgggagatc	14	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:156928929G>A	ENST00000368194.3	-	16	2327	c.1288C>T	c.(1288-1290)Cgc>Tgc	p.R430C	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.R390C	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	390	RGSL.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTCCGCAGGCGCGAGTCTGTA	0.572													11	13					0	0	1	0	0	A	156928929	G	A	156928929	3	1	48	1	0	0	0	0	1	0	0	0	893	1087	38	1	3504	1	ARHGEF11	1	156928929	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	231566	156928929	92321692	249	4643										
ARHGEF11	9826	broad.mit.edu	37	chr1	157014242	157014242	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaacttgaagatagaatcCtttctcctccagctctcagg	6	14	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:157014242C>A	ENST00000368194.3	-	0	920				ARHGEF11_ENST00000361409.2_De_novo_Start_OutOfFrame	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11						actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGATAGAATCCTTTCTCCTCC	0.498													3	8					0.004672	0.00483628	1	1	0	A	157014242	C	A	157014242	1	1	48	1	0	0	0	0	0	0	0	0	893	696	24	5		5	ARHGEF11	1	157014242	Translation_Start_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	85313	157014242	92236379	250	4644										
FCRL3	115352	broad.mit.edu	37	chr1	157659642	157659642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagcagcagcagcaaggaCgaggatgctgagcaccagcc	14	12	0	1	rs145354138	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:157659642C>T	ENST00000368184.3	-	10	2047	c.1756G>A	c.(1756-1758)Gtc>Atc	p.V586I	FCRL3_ENST00000368186.5_Missense_Mutation_p.V586I|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	586						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GCAGCAAGGACGAGGATGCTG	0.567													24	36					0	0	1	0	0	T	157659642	C	T	157659642	3	4	48	1	0	0	0	0	1	0	0	0	5828	536	19	1	472	1	FCRL3	1	157659642	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	645400	157659642	91590979	251	4645										
FCRL3	115352	broad.mit.edu	37	chr1	157667524	157667524	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcctataagcagtacaatGatatttgctattatccctgg	6	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:157667524G>T	ENST00000368184.3	-	5	775	c.484C>A	c.(484-486)Cat>Aat	p.H162N	FCRL3_ENST00000368186.5_Missense_Mutation_p.H162N|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	162	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GCAGTACAATGATATTTGCTA	0.338													28	42					4.43304e-23	6.18842e-23	1	1	0	T	157667524	G	T	157667524	3	4	48	1	0	0	0	0	1	0	0	0	5828	1290	45	2	1764	2	FCRL3	1	157667524	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7882	157667524	91583097	252	4646										
KIRREL	55243	broad.mit.edu	37	chr1	158064879	158064879	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcactcggactacggccagcGattccagcagcgcatgcaga	12	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158064879G>A	ENST00000368172.1	+	11	1697	c.1685G>A	c.(1684-1686)cGa>cAa	p.R562Q	KIRREL_ENST00000359209.6_Missense_Mutation_p.R748Q|KIRREL_ENST00000360089.4_Missense_Mutation_p.R584Q|KIRREL_ENST00000392272.2_Missense_Mutation_p.R645Q|KIRREL_ENST00000416935.2_Missense_Mutation_p.R648Q|KIRREL_ENST00000368173.3_Missense_Mutation_p.R764Q			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	748						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					TACGGCCAGCGATTCCAGCAG	0.607													11	20					0	0	1	0	0	A	158064879	G	A	158064879	3	1	48	1	0	0	0	0	1	0	0	0	8366	1058	37	1	2301	1	KIRREL	1	158064879	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	397355	158064879	91185742	253	4647										
CD1A	909	broad.mit.edu	37	chr1	158225933	158225933	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgccatatccagtggctggGaatatggccaagcatttctg	11	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158225933G>A	ENST00000289429.5	+	3	998	c.465G>A	c.(463-465)ggG>ggA	p.G155G		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	155					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex		p.G155G(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CAGTGGCTGGGAATATGGCCA	0.443													29	61					0	0	1	0	0	A	158225933	G	A	158225933	2	1	48	1	0	0	0	0	0	0	0	1	2996	1161	41	3		3	CD1A	1	158225933	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	161054	158225933	91024688	254	4648										
CD1C	911	broad.mit.edu	37	chr1	158263087	158263087	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgtgttatggtttaagaaGcactggtgagttttttgtat	11	3	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158263087G>A	ENST00000368170.3	+	5	1254	c.975G>A	c.(973-975)aaG>aaA	p.K325K		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	325					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					GGTTTAAGAAGCACTGGTGAG	0.393													18	85					0	0	1	0	0	A	158263087	G	A	158263087	2	1	48	1	0	0	0	0	0	0	0	1	2998	962	34	3		3	CD1C	1	158263087	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37154	158263087	90987534	255	4649										
OR10T2	128360	broad.mit.edu	37	chr1	158368397	158368397	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcagactgtagacaagaGgattaagtaagggagtaacc	11	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158368397G>T	ENST00000334438.1	-	1	859	c.860C>A	c.(859-861)cCt>cAt	p.P287H		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P287H(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					GTAGACAAGAGGATTAAGTAA	0.433													12	23					1.52009e-12	1.92208e-12	1	1	0	T	158368397	G	T	158368397	3	4	48	1	0	0	0	0	1	0	0	0	10966	1000	35	5	86	5	OR10T2	1	158368397	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	105310	158368397	90882224	256	4650										
OR10X1	128367	broad.mit.edu	37	chr1	158548750	158548750	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttcccatcattcttctaaAagcatttttcatgtccttat	3	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158548750A>C	ENST00000368150.1	-	1	939	c.940T>G	c.(940-942)Ttt>Gtt	p.F314V		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					ATTCTTCTAAAAGCATTTTTC	0.433													14	108					0	0	1	0	0	C	158548750	A	C	158548750	3	2	48	1	0	0	0	0	1	0	0	0	10969	14	1	4	35	4	OR10X1	1	158548750	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	180353	158548750	90701871	257	4651										
OR10X1	128367	broad.mit.edu	37	chr1	158549183	158549183	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctctgtaagagagataaaGaagcctgcagtgcaagcaga	12	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158549183G>T	ENST00000368150.1	-	1	506	c.507C>A	c.(505-507)ttC>ttA	p.F169L		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F169F(1)		breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					GAGAGATAAAGAAGCCTGCAG	0.468													23	25					7.41877e-09	8.8016e-09	1	1	0	T	158549183	G	T	158549183	3	4	48	1	0	0	0	0	1	0	0	0	10969	933	33	2	468	2	OR10X1	1	158549183	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	433	158549183	90701438	258	4652										
SPTA1	6708	broad.mit.edu	37	chr1	158582729	158582729	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcaggaaagcagtatagtCctccagtgagacatagccct	9	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158582729C>T	ENST00000368148.3	-	51	7192	c.7012G>A	c.(7012-7014)Gac>Aac	p.D2338N	SPTA1_ENST00000368147.3_Missense_Mutation_p.D2335N	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2338	EF-hand 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GCAGTATAGTCCTCCAGTGAG	0.468													17	33					0	0	1	0	0	T	158582729	C	T	158582729	3	4	48	1	0	0	0	0	1	0	0	0	15171	855	30	3	255	3	SPTA1	1	158582729	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	33546	158582729	90667892	259	4653										
SPTA1	6708	broad.mit.edu	37	chr1	158605732	158605732	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccaactctttgagcttctcCcagtgttcaacaaactgagc	7	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158605732C>A	ENST00000368148.3	-	38	5583	c.5403G>T	c.(5401-5403)tgG>tgT	p.W1801C	SPTA1_ENST00000368147.3_Missense_Mutation_p.W1801C	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1801					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.W1801C(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGAGCTTCTCCCAGTGTTCAA	0.522													42	88					1.59361e-14	2.07668e-14	1	1	0	A	158605732	C	A	158605732	3	1	48	1	0	0	0	0	1	0	0	0	15171	624	22	5	1916	5	SPTA1	1	158605732	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23003	158605732	90644889	260	4654										
OR6N2	81442	broad.mit.edu	37	chr1	158747230	158747230	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacaactccaagaaggaaaGaacactgacaaagtggtaca	8	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:158747230G>T	ENST00000339258.1	-	1	195	c.196C>A	c.(196-198)Ctt>Att	p.L66I		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					AAGAAGGAAAGAACACTGACA	0.438													9	195					0.00621372	0.0064192	1	1	0	T	158747230	G	T	158747230	3	4	48	1	0	0	0	0	1	0	0	0	11253	942	33	2	760	2	OR6N2	1	158747230	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	141498	158747230	90503391	261	4655										
FCER1A	2205	broad.mit.edu	37	chr1	159277721	159277721	+	Nonstop_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccaaaccccaaaaacaactGatataattactcaagaaata	3	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:159277721G>T	ENST00000368115.1	+	6	872	c.773G>T	c.(772-774)tGa>tTa	p.*258L	FCER1A_ENST00000368114.1_Nonstop_Mutation_p.*225L	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	0						integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	AAAAACAACTGATATAATTAC	0.378													10	22					0.0692343	0.0701576	1	1	0	T	159277721	G	T	159277721	4	4	48	1	0	0	0	0	0	0	0	0	5806	1285	45	2	791	2	FCER1A	1	159277721	Nonstop_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	530491	159277721	89972900	262	4656										
OR10J5	127385	broad.mit.edu	37	chr1	159505559	159505559	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatgaggctcaaaagcattCgtggcacaatgaccagtgtg	11	8	1	2	rs146863607		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:159505559C>T	ENST00000334857.2	-	1	283	c.239G>A	c.(238-240)cGa>cAa	p.R80Q		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R80Q(1)		kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					CAAAAGCATTCGTGGCACAAT	0.428													41	70					0	0	1	0	0	T	159505559	C	T	159505559	3	4	48	1	0	0	0	0	1	0	0	0	10959	884	31	1	692	1	OR10J5	1	159505559	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	227838	159505559	89745062	263	4657										
ATP1A2	477	broad.mit.edu	37	chr1	160106452	160106452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctactgggaatccgcctcGactgggatgaccggaccatg	14	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:160106452G>A	ENST00000361216.3	+	19	2745	c.2656G>A	c.(2656-2658)Gac>Aac	p.D886N	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.D886N	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	886					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AATCCGCCTCGACTGGGATGA	0.557													43	69					0	0	1	0	0	A	160106452	G	A	160106452	3	1	48	1	0	0	0	0	1	0	0	0	1128	1058	37	1	2730	1	ATP1A2	1	160106452	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	600893	160106452	89144169	264	4658										
ATP1A4	480	broad.mit.edu	37	chr1	160124942	160124942	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattctgtaagcaactgttCggaggcttctccctcctact	7	12	2	0	rs140019547	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:160124942C>T	ENST00000368081.4	+	3	786	c.315C>T	c.(313-315)ttC>ttT	p.F105F		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	105					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.F105F(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCAACTGTTCGGAGGCTTCT	0.512													27	53					0	0	1	0	0	T	160124942	C	T	160124942	2	4	48	1	0	0	0	0	0	0	0	1	1130	883	31	1		1	ATP1A4	1	160124942	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18490	160124942	89125679	265	4659										
PEX19	5824	broad.mit.edu	37	chr1	160252876	160252876	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatagttcctggaaaaacttCtcttgggaagcgaagagggc	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:160252876C>A	ENST00000368072.5	-	3	225	c.204G>T	c.(202-204)gaG>gaT	p.E68D	DCAF8_ENST00000556710.1_5'UTR|PEX19_ENST00000532508.1_5'UTR|PEX19_ENST00000440949.3_5'UTR	NM_001193644.1|NM_002857.3	NP_001180573.1|NP_002848.1			peroxisomal biogenesis factor 19											cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)	11	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGAAAAACTTCTCTTGGGAAG	0.542													25	45					1.37878e-21	1.90629e-21	1	1	0	A	160252876	C	A	160252876	3	1	48	1	0	0	0	0	1	0	0	0	11791	912	32	2	719	2	PEX19	1	160252876	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	127934	160252876	88997745	266	4660										
COPA	1314	broad.mit.edu	37	chr1	160276964	160276964	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaactcaccgaatgcatccGatctaggacagcaaaccgat	7	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:160276964G>A	ENST00000241704.7	-	14	1520	c.1291C>T	c.(1291-1293)Cgg>Tgg	p.R431W	COPA_ENST00000368069.3_Missense_Mutation_p.R431W	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	431					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity	p.R431W(1)		central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAATGCATCCGATCTAGGACA	0.478													77	128					0	0	1	0	0	A	160276964	G	A	160276964	3	1	48	1	0	0	0	0	1	0	0	0	3750	1057	37	1	2490	1	COPA	1	160276964	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24088	160276964	88973657	267	4661										
CD84	8832	broad.mit.edu	37	chr1	160519727	160519727	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttatcagcaaactgcacttCggaataaactgtgttcactg	7	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:160519727C>T	ENST00000368054.3	-	6	936	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K	CD84_ENST00000368051.3_Missense_Mutation_p.R268Q|CD84_ENST00000368048.3_Missense_Mutation_p.E312K|CD84_ENST00000311224.4_Missense_Mutation_p.E318K|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000534968.1_Missense_Mutation_p.E187K	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	318					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AACTGCACTTCGGAATAAACT	0.517													25	46					0	0	1	0	0	T	160519727	C	T	160519727	3	4	48	1	0	0	0	0	1	0	0	0	3064	893	31	1	93	1	CD84	1	160519727	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	242763	160519727	88730894	268	4662										
CD48	962	broad.mit.edu	37	chr1	160651093	160651093	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaattatgtggcataaggGtggtttcaagcacactgttc	11	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:160651093G>A	ENST00000368046.3	-	3	638	c.551C>T	c.(550-552)aCc>aTc	p.T184I	RP11-404F10.2_ENST00000443928.2_RNA|RP11-404F10.2_ENST00000588034.1_RNA	NM_001778.3	NP_001769.2	P09326	CD48_HUMAN	CD48 molecule	184	Ig-like C2-type 2.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGCATAAGGGTGGTTTCAAG	0.498													36	87					0	0	1	0	0	A	160651093	G	A	160651093	3	1	48	1	0	0	0	0	1	0	0	0	3042	1261	44	3	188	3	CD48	1	160651093	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	131366	160651093	88599528	269	4663										
FCRLB	127943	broad.mit.edu	37	chr1	161697300	161697300	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgtggaccttctgctccgaGaaatgcagctgctcaaaggc	11	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:161697300G>T	ENST00000367948.2	+	8	1344	c.1129G>T	c.(1129-1131)Gaa>Taa	p.E377*	FCRLB_ENST00000336830.5_3'UTR|FCRLB_ENST00000392158.1_Nonsense_Mutation_p.E377*|FCRLB_ENST00000367946.3_3'UTR|FCRLB_ENST00000367944.3_3'UTR|FCRLB_ENST00000367945.1_3'UTR|FCRLB_ENST00000495397.1_3'UTR			Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	377						endoplasmic reticulum				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|skin(1)	17	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TCTGCTCCGAGAAATGCAGCT	0.677													30	59					8.16721e-17	1.09032e-16	1	1	0	T	161697300	G	T	161697300	4	4	48	1	0	0	0	0	0	1	0	0	5833	943	33	2	1151	2	FCRLB	1	161697300	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1046207	161697300	87553321	270	4664										
ATF6	22926	broad.mit.edu	37	chr1	161882144	161882144	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaagaccaaaaatgtcaaTtgtgttaccagcaataaaca	5	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:161882144T>G	ENST00000367942.3	+	15	1845	c.1778T>G	c.(1777-1779)aTt>aGt	p.I593S		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	593					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			AAAATGTCAATTGTGTTACCA	0.328													10	29					0	0	1	0	0	G	161882144	T	G	161882144	3	3	48	1	0	0	0	0	1	0	0	0	1083	1493	52	4	1836	4	ATF6	1	161882144	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	184844	161882144	87368477	271	4665										
UAP1	6675	broad.mit.edu	37	chr1	162536047	162536047	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccagtcttctcaccaaaaGaatgtggatgcacgaatgga	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:162536047G>T	ENST00000271469.3	+	2	491	c.189G>T	c.(187-189)aaG>aaT	p.K63N	UAP1_ENST00000367925.1_Missense_Mutation_p.K63N|UAP1_ENST00000367924.1_Missense_Mutation_p.K63N|UAP1_ENST00000367926.4_Missense_Mutation_p.K63N			Q16222	UAP1_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1	63					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			breast(2)|cervix(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)|skin(2)|stomach(1)	22	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CTCACCAAAAGAATGTGGATG	0.478													14	15					1.41608e-15	1.86784e-15	1	1	0	T	162536047	G	T	162536047	3	4	48	1	0	0	0	0	1	0	0	0	16885	933	33	2	191	2	UAP1	1	162536047	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	653903	162536047	86714574	272	4666										
PBX1	5087	broad.mit.edu	37	chr1	164761784	164761784	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacagacccccagctgatgCggctggacaacatgctgtta	10	14	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:164761784C>T	ENST00000420696.2	+	3	507	c.319C>T	c.(319-321)Cgg>Tgg	p.R107W	PBX1_ENST00000367897.1_Missense_Mutation_p.R107W|PBX1_ENST00000401534.1_Missense_Mutation_p.R107W|PBX1_ENST00000560641.1_Missense_Mutation_p.R2W|PBX1_ENST00000559240.1_Missense_Mutation_p.R107W|PBX1_ENST00000540246.1_Missense_Mutation_p.R2W|PBX1_ENST00000540236.1_Missense_Mutation_p.R107W	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	107					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						CCAGCTGATGCGGCTGGACAA	0.627			T	"TCF3, EWSR1"	"pre B-ALL, myoepithelioma"								23	26					0	0	1	0	0	T	164761784	C	T	164761784	3	4	48	1	0	0	0	0	1	0	0	0	11538	759	27	1	329	1	PBX1	1	164761784	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2225737	164761784	84488837	273	4667										
UCK2	7371	broad.mit.edu	37	chr1	165860500	165860500	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcattctcaaaacactcaaAgaaatcactgaagggaaaac	5	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:165860500A>C	ENST00000367879.4	+	3	600	c.297A>C	c.(295-297)aaA>aaC	p.K99N	UCK2_ENST00000372212.4_Missense_Mutation_p.K99N	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	99					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					AAACACTCAAAGAAATCACTG	0.403													14	40					0	0	1	0	0	C	165860500	A	C	165860500	3	2	48	1	0	0	0	0	1	0	0	0	16983	69	3	4	307	4	UCK2	1	165860500	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1098716	165860500	83390121	274	4668										
MAEL	84944	broad.mit.edu	37	chr1	166974561	166974561	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatctaccaacaaaaatttCtcaaggagccctctaagact	6	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:166974561C>A	ENST00000367872.4	+	8	1016	c.772C>A	c.(772-774)Ctc>Atc	p.L258I	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.L227I	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	258					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						ACAAAAATTTCTCAAGGAGCC	0.398													14	18					1.52009e-12	1.92208e-12	1	1	0	A	166974561	C	A	166974561	3	1	48	1	0	0	0	0	1	0	0	0	9199	913	32	2	802	2	MAEL	1	166974561	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1114061	166974561	82276060	275	4669										
MAEL	84944	broad.mit.edu	37	chr1	166985488	166985488	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatgaagaaaatgatattcTcttctgtgctttagctgttt	8	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:166985488T>C	ENST00000367872.4	+	9	1119	c.875T>C	c.(874-876)cTc>cCc	p.L292P	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.L261P	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	292					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						AATGATATTCTCTTCTGTGCT	0.348													4	55					0	0	1	0	0	C	166985488	T	C	166985488	3	2	48	1	0	0	0	0	1	0	0	0	9199	1551	54	4	909	4	MAEL	1	166985488	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	10927	166985488	82265133	276	4670										
MAEL	84944	broad.mit.edu	37	chr1	166991017	166991017	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagcaatatccacaaattCtccaactgtgacacttcact	3	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:166991017C>A	ENST00000367872.4	+	12	1474	c.1230C>A	c.(1228-1230)ttC>ttA	p.F410L	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.F379L	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	410					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						TCCACAAATTCTCCAACTGTG	0.403													33	47					4.4194e-11	5.4833e-11	1	1	0	A	166991017	C	A	166991017	3	1	48	1	0	0	0	0	1	0	0	0	9199	912	32	2	1276	2	MAEL	1	166991017	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5529	166991017	82259604	277	4671										
ADCY10	55811	broad.mit.edu	37	chr1	167817657	167817657	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaccacttgtgaggtgacaGacttcttcactttccttatc	6	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:167817657G>T	ENST00000367848.1	-	19	2600	c.2103C>A	c.(2101-2103)gtC>gtA	p.V701V	ADCY10_ENST00000545172.1_Silent_p.V640V|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.V793V			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	793					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding	p.V793V(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TGAGGTGACAGACTTCTTCAC	0.433													7	45					5.18039e-06	5.75679e-06	1	1	0	T	167817657	G	T	167817657	2	4	48	1	0	0	0	0	0	0	0	1	292	929	33	2		2	ADCY10	1	167817657	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	826640	167817657	81432964	278	4672										
ADCY10	55811	broad.mit.edu	37	chr1	167844384	167844384	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctacccagcaaagggtaatCctcctttctgttgcagatga	8	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:167844384C>T	ENST00000367848.1	-	13	1668	c.1171G>A	c.(1171-1173)Gat>Aat	p.D391N	ADCY10_ENST00000545172.1_Missense_Mutation_p.D330N|ADCY10_ENST00000367851.4_Missense_Mutation_p.D483N			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	483	Guanylate cyclase 2.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding	p.D483N(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AAAGGGTAATCCTCCTTTCTG	0.393													20	37					0	0	1	0	0	T	167844384	C	T	167844384	3	4	48	1	0	0	0	0	1	0	0	0	292	855	30	3	3469	3	ADCY10	1	167844384	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	26727	167844384	81406237	279	4673										
DCAF6	55827	broad.mit.edu	37	chr1	167944083	167944083	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaggttttgacaacaattCgttcagggcaccgagcaaac	9	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:167944083C>T	ENST00000367840.3	+	4	362	c.268C>T	c.(268-270)Cgt>Tgt	p.R90C	DCAF6_ENST00000312263.6_Missense_Mutation_p.R90C|DCAF6_ENST00000432587.2_Missense_Mutation_p.R59C|DCAF6_ENST00000470919.1_3'UTR|DCAF6_ENST00000367843.3_Missense_Mutation_p.R90C	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	90					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						GACAACAATTCGTTCAGGGCA	0.313													26	32					0	0	1	0	0	T	167944083	C	T	167944083	3	4	48	1	0	0	0	0	1	0	0	0	4298	884	31	1	282	1	DCAF6	1	167944083	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	99699	167944083	81306538	280	4674										
XCL2	6846	broad.mit.edu	37	chr1	168513198	168513198	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagggccaggatgagaagtCtcatggctgaggtcccgctg	17	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:168513198C>A	ENST00000367819.2	-	1	37	c.5G>T	c.(4-6)aGa>aTa	p.R2I		NM_003175.3	NP_003166.1	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2	2					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			large_intestine(1)|lung(6)|ovary(1)	8	all_hematologic(923;0.215)					GATGAGAAGTCTCATGGCTGA	0.522													20	48					7.41877e-09	8.8016e-09	1	1	0	A	168513198	C	A	168513198	3	1	48	1	0	0	0	0	1	0	0	0	17483	913	32	2	351	2	XCL2	1	168513198	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	569115	168513198	80737423	281	4675										
F5	2153	broad.mit.edu	37	chr1	169511762	169511762	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgttcttgacttttgaattCtccagcaccaagtgaaagta	7	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:169511762C>A	ENST00000367796.3	-	13	2782	c.2581G>T	c.(2581-2583)Gaa>Taa	p.E861*	F5_ENST00000367797.3_Nonsense_Mutation_p.E856*			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	856	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTTTTGAATTCTCCAGCACCA	0.448													72	108					6.5469e-37	9.42237e-37	1	1	0	A	169511762	C	A	169511762	4	1	48	1	0	0	0	0	0	1	0	0	5376	922	32	2	4160	2	F5	1	169511762	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	998564	169511762	79738859	282	4676										
F5	2153	broad.mit.edu	37	chr1	169529841	169529841	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccccgagttgaaatcctcGatcagattttcatgggagta	10	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:169529841G>A	ENST00000367796.3	-	4	738	c.537C>T	c.(535-537)atC>atT	p.I179I	F5_ENST00000546081.1_Silent_p.I42I|F5_ENST00000367797.3_Silent_p.I179I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	179	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGAAATCCTCGATCAGATTTT	0.458													37	68					0	0	1	0	0	A	169529841	G	A	169529841	2	1	48	1	0	0	0	0	0	0	0	1	5376	1048	37	1		1	F5	1	169529841	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	18079	169529841	79720780	283	4677										
SELP	6403	broad.mit.edu	37	chr1	169578790	169578790	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtcccaagttatcacaccGaactatatcggctcctctca	5	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:169578790G>A	ENST00000263686.6	-	8	1322	c.1285C>T	c.(1285-1287)Cgg>Tgg	p.R429W	SELP_ENST00000367792.2_Missense_Mutation_p.R367W|SELP_ENST00000367794.2_Missense_Mutation_p.R367W|SELP_ENST00000367788.2_Missense_Mutation_p.R367W|SELP_ENST00000367791.2_Intron|SELP_ENST00000367793.2_Missense_Mutation_p.R367W|SELP_ENST00000367786.2_Missense_Mutation_p.R367W|SELP_ENST00000458599.2_Missense_Mutation_p.R367W	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	429	Sushi 4.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TTATCACACCGAACTATATCG	0.488													24	45					0	0	1	0	0	A	169578790	G	A	169578790	3	1	48	1	0	0	0	0	1	0	0	0	14072	1057	37	1	1243	1	SELP	1	169578790	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	48949	169578790	79671831	284	4678										
SELP	6403	broad.mit.edu	37	chr1	169582846	169582846	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattcacattctggcccataGaatccagggtaacaggagca	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:169582846G>T	ENST00000263686.6	-	4	604	c.567C>A	c.(565-567)ttC>ttA	p.F189L	SELP_ENST00000367792.2_Missense_Mutation_p.F189L|SELP_ENST00000367794.2_Missense_Mutation_p.F189L|SELP_ENST00000367788.2_Missense_Mutation_p.F189L|SELP_ENST00000367791.2_Missense_Mutation_p.F189L|SELP_ENST00000367793.2_Missense_Mutation_p.F189L|SELP_ENST00000367786.2_Missense_Mutation_p.F189L|SELP_ENST00000458599.2_Missense_Mutation_p.F189L	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	189	EGF-like.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CTGGCCCATAGAATCCAGGGT	0.448													4	77					0.00909568	0.00935351	1	1	0	T	169582846	G	T	169582846	3	4	48	1	0	0	0	0	1	0	0	0	14072	933	33	2	1977	2	SELP	1	169582846	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4056	169582846	79667775	285	4679										
C1orf112	55732	broad.mit.edu	37	chr1	169776949	169776949	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggcagagccttaagcaccAgtccataataaaaagccagt	8	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:169776949A>G	ENST00000286031.6	+	8	1281	c.581A>G	c.(580-582)cAg>cGg	p.Q194R	C1orf112_ENST00000413811.2_Missense_Mutation_p.Q165R|C1orf112_ENST00000359326.4_Missense_Mutation_p.Q194R|C1orf112_ENST00000456684.1_Missense_Mutation_p.Q252R|C1orf112_ENST00000498289.1_3'UTR	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	194										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTAAGCACCAGTCCATAATA	0.348													24	35					0	0	1	0	0	G	169776949	A	G	169776949	3	3	48	1	0	0	0	0	1	0	0	0	1998	188	7	4	603	4	C1orf112	1	169776949	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	194103	169776949	79473672	286	4680										
GORAB	92344	broad.mit.edu	37	chr1	170508562	170508562	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttccgagtcatttcactctCacctcccccgttggtgatgg	8	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:170508562C>T	ENST00000367763.3	+	2	368	c.348C>T	c.(346-348)ctC>ctT	p.L116L	GORAB_ENST00000465717.1_3'UTR|GORAB_ENST00000367762.1_Silent_p.L116L	NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	116						Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						ATTTCACTCTCACCTCCCCCG	0.468													23	53					0	0	1	0	0	T	170508562	C	T	170508562	2	4	48	1	0	0	0	0	0	0	0	1	6612	813	29	3		3	GORAB	1	170508562	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	731613	170508562	78742059	287	4681										
PRRX1	5396	broad.mit.edu	37	chr1	170633455	170633455	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaccctgcaggcgaaaaaGaacttctccgtcagtcacct	8	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:170633455G>A	ENST00000239461.6	+	1	409	c.96G>A	c.(94-96)aaG>aaA	p.K32K	PRRX1_ENST00000367760.3_Silent_p.K32K|PRRX1_ENST00000497230.2_Silent_p.K32K	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	32						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGGCGAAAAAGAACTTCTCCG	0.667													4	30					0	0	1	0	0	A	170633455	G	A	170633455	2	1	48	1	0	0	0	0	0	0	0	1	12661	933	33	3		3	PRRX1	1	170633455	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	124893	170633455	78617166	288	4682										
PIGC	5279	broad.mit.edu	37	chr1	172411565	172411565	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccagataaccacaaaaacAcaaacactgcacagctgctg	5	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:172411565A>G	ENST00000367728.1	-	1	1661	c.198T>C	c.(196-198)tgT>tgC	p.C66C	PIGC_ENST00000344529.4_Silent_p.C66C|PIGC_ENST00000484368.1_Intron|PIGC_ENST00000258324.1_Silent_p.C66C|C1orf105_ENST00000367727.4_Intron			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	66					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						CCACAAAAACACAAACACTGC	0.478													48	112					0	0	1	0	0	G	172411565	A	G	172411565	2	3	48	1	0	0	0	0	0	0	0	1	11933	157	6	4		4	PIGC	1	172411565	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1778110	172411565	76839056	289	4683										
PIGC	5279	broad.mit.edu	37	chr1	172411630	172411630	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagcccaatattggtattTccgagcatggatgtttttcc	8	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:172411630T>C	ENST00000367728.1	-	1	1596	c.133A>G	c.(133-135)Aaa>Gaa	p.K45E	PIGC_ENST00000344529.4_Missense_Mutation_p.K45E|PIGC_ENST00000484368.1_Intron|PIGC_ENST00000258324.1_Missense_Mutation_p.K45E|C1orf105_ENST00000367727.4_Intron			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	45					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						TATTGGTATTTCCGAGCATGG	0.488													61	106					0	0	1	0	0	C	172411630	T	C	172411630	3	2	48	1	0	0	0	0	1	0	0	0	11933	1792	62	4	764	4	PIGC	1	172411630	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	65	172411630	76838991	290	4684										
FASLG	356	broad.mit.edu	37	chr1	172633520	172633520	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggagctgaggaaagtggcCcatttaacaggtctgtatct	12	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:172633520C>T	ENST00000367721.2	+	3	625	c.441C>T	c.(439-441)gcC>gcT	p.A147A	FASLG_ENST00000340030.3_3'UTR	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	147					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GGAAAGTGGCCCATTTAACAG	0.428													4	26					0	0	1	0	0	T	172633520	C	T	172633520	2	4	48	1	0	0	0	0	0	0	0	1	5714	610	22	3		3	FASLG	1	172633520	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	221890	172633520	76617101	291	4685										
TNFSF18	8995	broad.mit.edu	37	chr1	173020022	173020022	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttaaaggcatattttccaaGtggctcaaacacatttttgg	7	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173020022G>T	ENST00000404377.3	-	1	81	c.81C>A	c.(79-81)caC>caA	p.H27Q	TNFSF18_ENST00000239468.2_Missense_Mutation_p.H5Q|RP1-15D23.2_ENST00000432694.1_RNA	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	27					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						TATTTTCCAAGTGGCTCAAAC	0.383													16	15					0.000308642	0.000328443	1	1	0	T	173020022	G	T	173020022	3	4	48	1	0	0	0	0	1	0	0	0	16368	1020	36	5	530	5	TNFSF18	1	173020022	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	386502	173020022	76230599	292	4686										
TNFSF4	7292	broad.mit.edu	37	chr1	173155898	173155898	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaagtagcccttcagggaGatgagataaaacccatcaca	10	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173155898G>A	ENST00000281834.3	-	3	445	c.309C>T	c.(307-309)atC>atT	p.I103I	TNFSF4_ENST00000367718.1_Silent_p.I53I	NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	103					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						CCTTCAGGGAGATGAGATAAA	0.458													26	29					0	0	1	0	0	A	173155898	G	A	173155898	2	1	48	1	0	0	0	0	0	0	0	1	16369	932	33	3		3	TNFSF4	1	173155898	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	135876	173155898	76094723	293	4687										
KLHL20	27252	broad.mit.edu	37	chr1	173726179	173726179	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgatccacagaccaatgaAtggagaatggtggcttcaat	10	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173726179A>C	ENST00000209884.4	+	7	1168	c.1032A>C	c.(1030-1032)gaA>gaC	p.E344D	KLHL20_ENST00000546011.1_Missense_Mutation_p.E155D	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	344					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						AGACCAATGAATGGAGAATGG	0.458													7	101					0	0	1	0	0	C	173726179	A	C	173726179	3	2	48	1	0	0	0	0	1	0	0	0	8417	98	4	4	1054	4	KLHL20	1	173726179	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	570281	173726179	75524442	294	4688										
DARS2	55157	broad.mit.edu	37	chr1	173794441	173794441	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaaggaccacccaaccgaTctggggttctctctacagaa	9	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173794441T>C	ENST00000361951.4	+	1	801	c.74T>C	c.(73-75)aTc>aCc	p.I25T	DARS2_ENST00000239457.5_5'UTR	NM_018122.4	NP_060592.2	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	25					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			breast(4)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	30					L-Aspartic Acid(DB00128)	ACCCAACCGATCTGGGGTTCT	0.473													19	51					0	0	1	0	0	C	173794441	T	C	173794441	3	2	48	1	0	0	0	0	1	0	0	0	4266	1435	50	4	76	4	DARS2	1	173794441	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	68262	173794441	75456180	295	4689										
SERPINC1	462	broad.mit.edu	37	chr1	173873151	173873151	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttggggtttagcgaacggCcagcaatcacaacagcggta	13	9	1	0	rs121909566		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173873151C>T	ENST00000367698.3	-	7	1389	c.1271G>A	c.(1270-1272)gGc>gAc	p.G424D		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	424			G -> D (in AT3D; type-II; Stockholm).		blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	TAGCGAACGGCCAGCAATCAC	0.463													25	42					0	0	1	0	0	T	173873151	C	T	173873151	3	4	48	1	0	0	0	0	1	0	0	0	14162	739	26	3	127	3	SERPINC1	1	173873151	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	78710	173873151	75377470	296	4690										
SERPINC1	462	broad.mit.edu	37	chr1	173881126	173881126	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatctgatcagatgttttCtcagatatggtgtcaaactt	9	6	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173881126C>A	ENST00000367698.3	-	3	553	c.435G>T	c.(433-435)gaG>gaT	p.E145D	SERPINC1_ENST00000494024.1_5'UTR	NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	145					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CAGATGTTTTCTCAGATATGG	0.428													31	48					9.65021e-13	1.22324e-12	1	1	0	A	173881126	C	A	173881126	3	1	48	1	0	0	0	0	1	0	0	0	14162	912	32	2	979	2	SERPINC1	1	173881126	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7975	173881126	75369495	297	4691										
RC3H1	149041	broad.mit.edu	37	chr1	173910505	173910505	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttgcttttcatgtccagaGaacactggttttcctttgaa	8	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173910505G>T	ENST00000367696.2	-	19	3500	c.3149C>A	c.(3148-3150)tCt>tAt	p.S1050Y	RC3H1_ENST00000367694.2_Missense_Mutation_p.S1041Y|RC3H1_ENST00000258349.4_Missense_Mutation_p.S1050Y			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	1050					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						CATGTCCAGAGAACACTGGTT	0.363													21	45					7.45023e-12	9.31775e-12	1	1	0	T	173910505	G	T	173910505	3	4	48	1	0	0	0	0	1	0	0	0	13217	942	33	2	260	2	RC3H1	1	173910505	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29379	173910505	75340116	298	4692										
RC3H1	149041	broad.mit.edu	37	chr1	173962048	173962048	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccaaactgatgggctttcGaattgtttcgtcgaaagtct	9	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:173962048G>A	ENST00000367696.2	-	2	427	c.76C>T	c.(76-78)Cga>Tga	p.R26*	RC3H1_ENST00000367694.2_Nonsense_Mutation_p.R26*|RC3H1_ENST00000258349.4_Nonsense_Mutation_p.R26*			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	26					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						ATGGGCTTTCGAATTGTTTCG	0.473													6	77					0	0	1	0	0	A	173962048	G	A	173962048	4	1	48	1	0	0	0	0	0	1	0	0	13217	1066	37	1	3401	1	RC3H1	1	173962048	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	51543	173962048	75288573	299	4693										
RABGAP1L	9910	broad.mit.edu	37	chr1	174219751	174219751	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttggaggtaaaagaagacGatggaaaaggaaactttagg	13	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:174219751G>T	ENST00000251507.4	+	6	1030	c.856G>T	c.(856-858)Gat>Tat	p.D286Y	RABGAP1L_ENST00000357444.6_Missense_Mutation_p.D249Y|RABGAP1L_ENST00000367689.3_5'UTR	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	286					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						AAAAGAAGACGATGGAAAAGG	0.383													15	49					1.3612e-06	1.53357e-06	1	1	0	T	174219751	G	T	174219751	3	4	48	1	0	0	0	0	1	0	0	0	13016	1058	37	2	874	2	RABGAP1L	1	174219751	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	257703	174219751	75030870	300	4694										
GPR52	9293	broad.mit.edu	37	chr1	174417471	174417471	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctccactgttacatcattaTactaccagctatttcattca	3	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:174417471T>C	ENST00000367685.2	+	1	260	c.222T>C	c.(220-222)taT>taC	p.Y74Y	RABGAP1L_ENST00000357444.6_Intron|RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	74						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						TACATCATTATACTACCAGCT	0.418													52	76					0	0	1	0	0	C	174417471	T	C	174417471	2	2	48	1	0	0	0	0	0	0	0	1	6737	1413	49	4		4	GPR52	1	174417471	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	197720	174417471	74833150	301	4695										
RFWD2	64326	broad.mit.edu	37	chr1	176132020	176132020	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttactgcttccagttgtttCttcttctgcactagtaactc	5	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:176132020C>A	ENST00000367669.3	-	5	1261	c.747G>T	c.(745-747)aaG>aaT	p.K249N	RFWD2_ENST00000308769.8_Missense_Mutation_p.K245N	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	249					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						CCAGTTGTTTCTTCTTCTGCA	0.338													11	21					0.000673444	0.000709932	1	1	0	A	176132020	C	A	176132020	3	1	48	1	0	0	0	0	1	0	0	0	13311	912	32	2	1512	2	RFWD2	1	176132020	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1714549	176132020	73118601	302	4696										
RFWD2	64326	broad.mit.edu	37	chr1	176132999	176132999	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacctcttttcctcaaatctTtgcttctgtttaagaatgag	5	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:176132999T>G	ENST00000367669.3	-	4	1108	c.594A>C	c.(592-594)caA>caC	p.Q198H	RFWD2_ENST00000308769.8_Missense_Mutation_p.Q198H	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	198					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						CCTCAAATCTTTGCTTCTGTT	0.284													9	23					0	0	1	0	0	G	176132999	T	G	176132999	3	3	48	1	0	0	0	0	1	0	0	0	13311	1838	64	4	1669	4	RFWD2	1	176132999	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	979	176132999	73117622	303	4697										
ASTN1	460	broad.mit.edu	37	chr1	176903403	176903403	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctggatgtaatggttgccGaactggtccaacagcgccac	11	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:176903403G>A	ENST00000367654.2	-	16	2593	c.2580C>T	c.(2578-2580)ttC>ttT	p.F860F	ASTN1_ENST00000361833.2_Silent_p.F852F|ASTN1_ENST00000367657.3_Silent_p.F852F|ASTN1_ENST00000424564.2_Silent_p.F852F			O14525	ASTN1_HUMAN	astrotactin 1	860					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						AATGGTTGCCGAACTGGTCCA	0.542													25	32					0	0	1	0	0	A	176903403	G	A	176903403	2	1	48	1	0	0	0	0	0	0	0	1	1063	1049	37	1		1	ASTN1	1	176903403	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	770404	176903403	72347218	304	4698										
ASTN1	460	broad.mit.edu	37	chr1	177030254	177030254	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcagctcctcttctgccGactcatgttggggttcttca	8	14	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:177030254G>A	ENST00000367654.2	-	2	444	c.431C>T	c.(430-432)tCg>tTg	p.S144L	ASTN1_ENST00000361833.2_Missense_Mutation_p.S144L|ASTN1_ENST00000367657.3_Missense_Mutation_p.S144L|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.S144L			O14525	ASTN1_HUMAN	astrotactin 1	144					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CTCTTCTGCCGACTCATGTTG	0.507													47	88					0	0	1	0	0	A	177030254	G	A	177030254	3	1	48	1	0	0	0	0	1	0	0	0	1063	1059	37	1	3545	1	ASTN1	1	177030254	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	126851	177030254	72220367	305	4699										
ANGPTL1	9068	broad.mit.edu	37	chr1	178834092	178834092	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaagaggtaactcaccttCattgatgaaagttaccggtg	10	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:178834092C>A	ENST00000234816.2	-	3	1267	c.820G>T	c.(820-822)Gaa>Taa	p.E274*	RALGPS2_ENST00000367635.3_Intron|ANGPTL1_ENST00000367629.1_Nonsense_Mutation_p.E274*|RALGPS2_ENST00000367634.2_Intron|RALGPS2_ENST00000324778.4_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	274	Fibrinogen C-terminal.					extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						AACTCACCTTCATTGATGAAA	0.393													12	39					1.08611e-07	1.25818e-07	1	1	0	A	178834092	C	A	178834092	4	1	48	1	0	0	0	0	0	1	0	0	609	835	29	2	671	2	ANGPTL1	1	178834092	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1803838	178834092	70416529	306	4700										
RALGPS2	55103	broad.mit.edu	37	chr1	178875917	178875917	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggataattttaggaaattCgtacaagtttcaagctggca	9	5	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:178875917C>T	ENST00000367635.3	+	19	1975	c.1637C>T	c.(1636-1638)tCg>tTg	p.S546L	RALGPS2_ENST00000367634.2_Missense_Mutation_p.S520L|RALGPS2_ENST00000324778.4_Missense_Mutation_p.S511L	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	546	PH.|Required for stimulation of nucleotide exchange by RALA (By similarity).				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding	p.S546L(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TTAGGAAATTCGTACAAGTTT	0.333													12	22					0	0	1	0	0	T	178875917	C	T	178875917	3	4	48	1	0	0	0	0	1	0	0	0	13069	893	31	1	1707	1	RALGPS2	1	178875917	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	41825	178875917	70374704	307	4701										
TDRD5	163589	broad.mit.edu	37	chr1	179564769	179564769	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attactcacaaaaggtaaaaTttttacccagccatttagaa	4	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:179564769T>A	ENST00000444136.1	+	4	897	c.647T>A	c.(646-648)aTt>aAt	p.I216N	TDRD5_ENST00000367614.1_Missense_Mutation_p.I216N|TDRD5_ENST00000294848.8_Missense_Mutation_p.I216N	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	216	Lotus/OST-HTH 2.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						AAAGGTAAAATTTTTACCCAG	0.408													8	34					0	0	1	0	0	A	179564769	T	A	179564769	3	1	48	1	0	0	0	0	1	0	0	0	15791	1493	52	4	657	4	TDRD5	1	179564769	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	688852	179564769	69685852	308	4702										
TDRD5	163589	broad.mit.edu	37	chr1	179599930	179599930	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaagagcaactatcaccaaAaaaattaggcttcttaaatg	5	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:179599930A>C	ENST00000444136.1	+	7	1251	c.1001A>C	c.(1000-1002)aAa>aCa	p.K334T	TDRD5_ENST00000367614.1_Missense_Mutation_p.K334T|TDRD5_ENST00000294848.8_Missense_Mutation_p.K334T	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	334	Lotus/OST-HTH 3.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CTATCACCAAAAAAATTAGGC	0.328													16	34					0	0	1	0	0	C	179599930	A	C	179599930	3	2	48	1	0	0	0	0	1	0	0	0	15791	14	1	4	1023	4	TDRD5	1	179599930	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	35161	179599930	69650691	309	4703										
TOR1AIP1	26092	broad.mit.edu	37	chr1	179869292	179869292	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtccaacagaaggtcaatttCtctgaagaaggtattttact	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:179869292C>T	ENST00000435319.3	+	4	833	c.642C>T	c.(640-642)ttC>ttT	p.F214F	TOR1AIP1_ENST00000474875.1_3'UTR|TOR1AIP1_ENST00000271583.3_Silent_p.F215F	NM_001267578.1|NM_015602.3	NP_001254507.1|NP_056417.2	Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1	214						integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						AGGTCAATTTCTCTGAAGAAG	0.279													12	9					0	0	1	0	0	T	179869292	C	T	179869292	2	4	48	1	0	0	0	0	0	0	0	1	16432	912	32	3		3	TOR1AIP1	1	179869292	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	269362	179869292	69381329	310	4704										
CACNA1E	777	broad.mit.edu	37	chr1	181702655	181702655	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccccctagtcctgccccatCctgagctggaagtggggaag	12	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:181702655C>A	ENST00000526775.1	+	20	3139	c.2974C>A	c.(2974-2976)Cct>Act	p.P992T	CACNA1E_ENST00000358338.5_Missense_Mutation_p.P943T|CACNA1E_ENST00000367570.1_Missense_Mutation_p.P1011T|CACNA1E_ENST00000367573.2_Missense_Mutation_p.P1011T|CACNA1E_ENST00000360108.3_Missense_Mutation_p.P992T|CACNA1E_ENST00000357570.5_Missense_Mutation_p.P962T|CACNA1E_ENST00000367567.4_Missense_Mutation_p.P618T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1011					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCTGCCCCATCCTGAGCTGGA	0.627													12	25					5.50884e-06	6.10489e-06	1	1	0	A	181702655	C	A	181702655	3	1	48	1	0	0	0	0	1	0	0	0	2560	855	30	2	3113	2	CACNA1E	1	181702655	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1833363	181702655	67547966	311	4705										
CACNA1E	777	broad.mit.edu	37	chr1	181724489	181724489	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctcttcaagggaaagttCttttattgcacggacagttc	9	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:181724489C>A	ENST00000526775.1	+	27	4053	c.3888C>A	c.(3886-3888)ttC>ttA	p.F1296L	CACNA1E_ENST00000358338.5_Missense_Mutation_p.F1247L|CACNA1E_ENST00000367570.1_Missense_Mutation_p.F1315L|CACNA1E_ENST00000367573.2_Missense_Mutation_p.F1315L|CACNA1E_ENST00000360108.3_Missense_Mutation_p.F1296L|CACNA1E_ENST00000357570.5_Missense_Mutation_p.F1266L|CACNA1E_ENST00000367567.4_Missense_Mutation_p.F922L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1315					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.F1315L(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGGAAAGTTCTTTTATTGCA	0.448													69	115					2.165e-29	3.08197e-29	1	1	0	A	181724489	C	A	181724489	3	1	48	1	0	0	0	0	1	0	0	0	2560	912	32	2	4055	2	CACNA1E	1	181724489	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	21834	181724489	67526132	312	4706										
CACNA1E	777	broad.mit.edu	37	chr1	181727969	181727969	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaccatggtgttttccctgGaatgtgtcctgaaggtcatc	10	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:181727969G>T	ENST00000526775.1	+	31	4678	c.4513G>T	c.(4513-4515)Gaa>Taa	p.E1505*	CACNA1E_ENST00000358338.5_Nonsense_Mutation_p.E1456*|CACNA1E_ENST00000367570.1_Nonsense_Mutation_p.E1524*|CACNA1E_ENST00000367573.2_Nonsense_Mutation_p.E1524*|CACNA1E_ENST00000360108.3_Nonsense_Mutation_p.E1505*|CACNA1E_ENST00000357570.5_Nonsense_Mutation_p.E1475*|CACNA1E_ENST00000367567.4_Nonsense_Mutation_p.E1131*	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1524					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GTTTTCCCTGGAATGTGTCCT	0.478													22	37					0.000375601	0.000399622	1	1	0	T	181727969	G	T	181727969	4	4	48	1	0	0	0	0	0	1	0	0	2560	1175	41	2	4696	2	CACNA1E	1	181727969	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3480	181727969	67522652	313	4707										
DHX9	1660	broad.mit.edu	37	chr1	182821465	182821465	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggacctcttcctccacatcTggctctcaaagcaggtaagg	9	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:182821465T>G	ENST00000367549.3	+	4	460	c.350T>G	c.(349-351)cTg>cGg	p.L117R		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	117	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						CCTCCACATCTGGCTCTCAAA	0.468													12	23					0	0	1	0	0	G	182821465	T	G	182821465	3	3	48	1	0	0	0	0	1	0	0	0	4544	1580	55	4	360	4	DHX9	1	182821465	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1093496	182821465	66429156	314	4708										
DHX9	1660	broad.mit.edu	37	chr1	182848417	182848417	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgacaccagagatgttccGaacaccattgcatgaaattg	8	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:182848417G>A	ENST00000367549.3	+	21	2494	c.2384G>A	c.(2383-2385)cGa>cAa	p.R795Q	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	795	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GAGATGTTCCGAACACCATTG	0.398													22	65					0	0	1	0	0	A	182848417	G	A	182848417	3	1	48	1	0	0	0	0	1	0	0	0	4544	1058	37	1	2462	1	DHX9	1	182848417	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	26952	182848417	66402204	315	4709										
LAMC1	3915	broad.mit.edu	37	chr1	183102561	183102561	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatgaacaagcgaagaacaTctcacaggatctggaaaaac	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:183102561T>C	ENST00000258341.4	+	22	3982	c.3725T>C	c.(3724-3726)aTc>aCc	p.I1242T		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	1242	Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGAAGAACATCTCACAGGAT	0.443													45	91					0	0	1	0	0	C	183102561	T	C	183102561	3	2	48	1	0	0	0	0	1	0	0	0	8652	1435	50	4	3811	4	LAMC1	1	183102561	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	254144	183102561	66148060	316	4710										
SMG7	9887	broad.mit.edu	37	chr1	183502819	183502819	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttttttcaagtgtcttttCttggcatcctgtgcaagtgt	8	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:183502819C>A	ENST00000367537.3	+	11	1297	c.1102C>A	c.(1102-1104)Ctt>Att	p.L368I	SMG7_ENST00000507469.1_Missense_Mutation_p.L339I|SMG7_ENST00000347615.2_Missense_Mutation_p.L339I|SMG7_ENST00000515829.2_Missense_Mutation_p.L339I|SMG7_ENST00000508461.1_Missense_Mutation_p.L297I|SMG7_ENST00000456731.2_Missense_Mutation_p.L297I			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	339					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						AGTGTCTTTTCTTGGCATCCT	0.383													16	21					2.32078e-09	2.7896e-09	1	1	0	A	183502819	C	A	183502819	3	1	48	1	0	0	0	0	1	0	0	0	14851	913	32	2	1053	2	SMG7	1	183502819	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	400258	183502819	65747802	317	4711										
FAM129A	116496	broad.mit.edu	37	chr1	184787866	184787866	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacgtacttcactgaatcccGagctcactggtcccatgagc	8	15	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:184787866G>A	ENST00000367511.3	-	9	1272	c.1079C>T	c.(1078-1080)tCg>tTg	p.S360L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	360					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane		p.S360*(1)		autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						ACTGAATCCCGAGCTCACTGG	0.542													22	157					0	0	1	0	0	A	184787866	G	A	184787866	3	1	48	1	0	0	0	0	1	0	0	0	5467	1059	37	1	1731	1	FAM129A	1	184787866	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1285047	184787866	64462755	318	4712										
RNF2	6045	broad.mit.edu	37	chr1	185069003	185069003	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttagctttagaagaacttcGaagcaaaggtgaatcaaacc	9	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:185069003G>A	ENST00000367510.3	+	6	1106	c.818G>A	c.(817-819)cGa>cAa	p.R273Q	RNF2_ENST00000367509.4_Missense_Mutation_p.R201Q	NM_007212.3	NP_009143.1	Q99496	RING2_HUMAN	ring finger protein 2	273					histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(3)|endometrium(2)|large_intestine(4)|lung(3)|skin(2)	14		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		GAAGAACTTCGAAGCAAAGGT	0.393													27	52					0	0	1	0	0	A	185069003	G	A	185069003	3	1	48	1	0	0	0	0	1	0	0	0	13523	1058	37	1	836	1	RNF2	1	185069003	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	281137	185069003	64181618	319	4713										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185278208	185278208	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaaatttaacgtgagaaaTtccatgaggatcactatcac	6	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:185278208T>G	ENST00000367498.3	-	4	830	c.208A>C	c.(208-210)Att>Ctt	p.I70L	IVNS1ABP_ENST00000367497.1_Missense_Mutation_p.I70L|IVNS1ABP_ENST00000459929.1_5'UTR|IVNS1ABP_ENST00000392007.3_5'UTR	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	70	BTB.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						ACGTGAGAAATTCCATGAGGA	0.378													11	21					0	0	1	0	0	G	185278208	T	G	185278208	3	3	48	1	0	0	0	0	1	0	0	0	7973	1493	52	4	1768	4	IVNS1ABP	1	185278208	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	209205	185278208	63972413	320	4714										
HMCN1	83872	broad.mit.edu	37	chr1	185970453	185970453	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccagtaattaaagataaaGaacaagttacaaatgtgtcg	7	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:185970453G>T	ENST00000271588.4	+	27	4322	c.4093G>T	c.(4093-4095)Gaa>Taa	p.E1365*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.E1365*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1365	Ig-like C2-type 11.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TAAAGATAAAGAACAAGTTAC	0.343													17	35					1.99824e-07	2.29918e-07	1	1	0	T	185970453	G	T	185970453	4	4	48	1	0	0	0	0	0	1	0	0	7260	943	33	2	4199	2	HMCN1	1	185970453	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	692245	185970453	63280168	321	4715										
HMCN1	83872	broad.mit.edu	37	chr1	186055441	186055441	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtggtgaacaatttcatctCtttgacctgtgaggtctctg	10	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:186055441C>A	ENST00000271588.4	+	58	9177	c.8948C>A	c.(8947-8949)tCt>tAt	p.S2983Y	HMCN1_ENST00000367492.2_Missense_Mutation_p.S2983Y	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2983	Ig-like C2-type 28.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AATTTCATCTCTTTGACCTGT	0.413													18	29					1.99824e-07	2.29918e-07	1	1	0	A	186055441	C	A	186055441	3	1	48	1	0	0	0	0	1	0	0	0	7260	913	32	2	9178	2	HMCN1	1	186055441	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	84988	186055441	63195180	322	4716										
PRG4	10216	broad.mit.edu	37	chr1	186275466	186275466	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagtaaaagataacaagaaGaacagaactaaaaagaaacc	6	7	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:186275466G>T	ENST00000445192.2	+	7	660	c.615G>T	c.(613-615)aaG>aaT	p.K205N	PRG4_ENST00000367483.4_Missense_Mutation_p.K164N|PRG4_ENST00000367485.4_Missense_Mutation_p.K112N|PRG4_ENST00000367484.3_Missense_Mutation_p.K164N|PRG4_ENST00000367486.3_Missense_Mutation_p.K162N	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	205					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ATAACAAGAAGAACAGAACTA	0.343													49	97					2.56175e-15	3.37031e-15	1	1	0	T	186275466	G	T	186275466	3	4	48	1	0	0	0	0	1	0	0	0	12532	933	33	2	637	2	PRG4	1	186275466	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	220025	186275466	62975155	323	4717										
TPR	7175	broad.mit.edu	37	chr1	186321228	186321228	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttccttttccttcttcaaAttttctgctcttacctaaac	1	12	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:186321228A>C	ENST00000367478.3	-	19	2645	c.2349T>G	c.(2347-2349)aaT>aaG	p.N783K	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	783					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CCTTCTTCAAATTTTCTGCTC	0.308			T	NTRK1	papillary thyroid								6	44					0	0	1	0	0	C	186321228	A	C	186321228	3	2	48	1	0	0	0	0	1	0	0	0	16476	98	4	4	4874	4	TPR	1	186321228	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	45762	186321228	62929393	324	4718										
OCLM	10896	broad.mit.edu	37	chr1	186370207	186370207	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatccaccattattgttaaaGatttaccttagcagacacat	4	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:186370207G>T	ENST00000574641.1	+	1	504	c.30G>T	c.(28-30)aaG>aaT	p.K10N	C1orf27_ENST00000432021.3_Intron|C1orf27_ENST00000367470.3_Intron|C1orf27_ENST00000419367.3_Intron|C1orf27_ENST00000287859.6_Intron	NM_022375.3	NP_071770.1	Q9Y5M6	TISR_HUMAN	oculomedin	10					visual perception												TATTGTTAAAGATTTACCTTA	0.338													31	54					9.65963e-10	1.17364e-09	1	1	0	T	186370207	G	T	186370207	3	4	48	1	0	0	0	0	1	0	0	0	10866	933	33	2	32	2	OCLM	1	186370207	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	48979	186370207	62880414	325	4719										
PDC	5132	broad.mit.edu	37	chr1	186415580	186415580	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgctgactcgttcctttGaatctttgccattcctactc	5	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:186415580G>T	ENST00000391997.2	-	3	278	c.191C>A	c.(190-192)tCa>tAa	p.S64*	PDC_ENST00000456239.2_Nonsense_Mutation_p.S12*|PDC_ENST00000340129.5_Nonsense_Mutation_p.S64*|PDC_ENST00000497198.1_Nonsense_Mutation_p.S12*	NM_002597.4	NP_002588.3	P20941	PHOS_HUMAN	phosducin	64					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		TCGTTCCTTTGAATCTTTGCC	0.338													18	27					0.000566183	0.00059967	1	1	0	T	186415580	G	T	186415580	4	4	48	1	0	0	0	0	0	1	0	0	11660	1294	45	2	557	2	PDC	1	186415580	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	45373	186415580	62835041	326	4720										
FAM5C	0	broad.mit.edu	37	chr1	190129925	190129925	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccagttgttcataacggcGctgaaaattagaatccattg	8	9	1	2	rs147790033		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:190129925G>A	ENST00000367462.3	-	7	1288	c.1057C>T	c.(1057-1059)Cgc>Tgc	p.R353C	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.R251C	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		353						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TCATAACGGCGCTGAAAATTA	0.353													46	44					0	0	1	0	0	A	190129925	G	A	190129925	3	1	48	1	0	0	0	0	1	0	0	0	5628	1087	38	1	1251	1	FAM5C	1	190129925	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3714345	190129925	59120696	327	4721										
UCHL5	51377	broad.mit.edu	37	chr1	192993056	192993056	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatggccattaaattaaatCgaatttcaccttcactgtac	4	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:192993056C>T	ENST00000367452.4	-	8	1048	c.278G>A	c.(277-279)cGa>cAa	p.R93Q	UCHL5_ENST00000367455.3_Missense_Mutation_p.R217Q|UCHL5_ENST00000367451.4_Missense_Mutation_p.R244Q|UCHL5_ENST00000367448.1_Missense_Mutation_p.R217Q|UCHL5_ENST00000367454.1_Missense_Mutation_p.R217Q|UCHL5_ENST00000530098.2_Missense_Mutation_p.R93Q|UCHL5_ENST00000367449.1_Missense_Mutation_p.R217Q			Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	217					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(1)|lung(9)|ovary(1)	19						TAAATTAAATCGAATTTCACC	0.333													8	18					0	0	1	0	0	T	192993056	C	T	192993056	3	4	48	1	0	0	0	0	1	0	0	0	16981	884	31	1	355	1	UCHL5	1	192993056	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2863131	192993056	56257565	328	4722										
TROVE2	6738	broad.mit.edu	37	chr1	193053858	193053858	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatttcacattagatatgatTtaaccataagcagcagcacg	6	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:193053858T>G	ENST00000432079.1	+	8	1357	c.789T>G	c.(787-789)atT>atG	p.I263M	TROVE2_ENST00000367443.1_Intron|TROVE2_ENST00000400968.2_Missense_Mutation_p.I538M|TROVE2_ENST00000367445.3_Intron|TROVE2_ENST00000416058.2_Missense_Mutation_p.I263M|TROVE2_ENST00000367444.3_Intron|TROVE2_ENST00000367441.1_Missense_Mutation_p.I538M|TROVE2_ENST00000367446.3_Missense_Mutation_p.I538M|TROVE2_ENST00000460715.2_3'UTR			P10155	RO60_HUMAN	TROVE domain family, member 2	538	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						TAGATATGATTTAACCATAAG	0.418													10	43					0	0	1	0	0	G	193053858	T	G	193053858	3	3	48	1	0	0	0	0	1	0	0	0	16636	1829	64	4	1644	4	TROVE2	1	193053858	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	60802	193053858	56196763	329	4723										
CDC73	79577	broad.mit.edu	37	chr1	193119493	193119493	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tataacagatacgatcaggaAagattcaaaggaaaagaagg	10	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:193119493A>C	ENST00000367435.3	+	9	1072	c.888A>C	c.(886-888)gaA>gaC	p.E296D		NM_024529.4	NP_078805.3	Q6P1J9	CDC73_HUMAN	cell division cycle 73	296					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(14)|ovary(1)|pancreas(1)|parathyroid(51)|skin(1)|upper_aerodigestive_tract(1)	87						ACGATCAGGAAAGATTCAAAG	0.383													10	26					0	0	1	0	0	C	193119493	A	C	193119493	3	2	48	1	0	0	0	0	1	0	0	0	3107	11	1	4	922	4	CDC73	1	193119493	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	65635	193119493	56131128	330	4724										
CFHR5	81494	broad.mit.edu	37	chr1	196977765	196977765	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatatcatcaccaccattTcgagcaatctgtcaggaagg	8	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:196977765T>G	ENST00000367414.5	+	10	1790	c.1734T>G	c.(1732-1734)ttT>ttG	p.F578L	CFHR5_ENST00000256785.4_Missense_Mutation_p.F554L	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	554					complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						CACCACCATTTCGAGCAATCT	0.353													20	44					0	0	1	0	0	G	196977765	T	G	196977765	3	3	48	1	0	0	0	0	1	0	0	0	3310	1780	62	4	1700	4	CFHR5	1	196977765	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3858272	196977765	52272856	331	4725										
F13B	2165	broad.mit.edu	37	chr1	197008508	197008508	+	Nonstop_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctttctgccattcatttCtatgttcttaagggttcttg	6	10	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197008508C>A	ENST00000367412.1	-	12	2029	c.1986G>T	c.(1984-1986)taG>taT	p.*662Y		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	0					blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						CCATTCATTTCTATGTTCTTA	0.313													10	123					2.80697e-09	3.36108e-09	1	1	0	A	197008508	C	A	197008508	4	1	48	1	0	0	0	0	0	0	0	0	5369	924	32	2	3	2	F13B	1	197008508	Nonstop_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30743	197008508	52242113	332	4726										
ASPM	259266	broad.mit.edu	37	chr1	197073886	197073886	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttgggcttgaaagcaccGaaatcttttctgaatgataa	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197073886G>A	ENST00000367409.4	-	18	4751	c.4495C>T	c.(4495-4497)Cgg>Tgg	p.R1499W	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1499					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TGAAAGCACCGAAATCTTTTC	0.313													12	23					0	0	1	0	0	A	197073886	G	A	197073886	3	1	48	1	0	0	0	0	1	0	0	0	1055	1057	37	1	5982	1	ASPM	1	197073886	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65378	197073886	52176735	333	4727										
ASPM	259266	broad.mit.edu	37	chr1	197099114	197099114	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaggattccaaagtaggcGattcagaataaacatagcca	8	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197099114G>A	ENST00000367409.4	-	8	2816	c.2560C>T	c.(2560-2562)Cgc>Tgc	p.R854C	ASPM_ENST00000367408.1_Missense_Mutation_p.R104C|ASPM_ENST00000294732.7_Missense_Mutation_p.R854C	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	854					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CAAAGTAGGCGATTCAGAATA	0.403													32	51					0	0	1	0	0	A	197099114	G	A	197099114	3	1	48	1	0	0	0	0	1	0	0	0	1055	1058	37	1	7957	1	ASPM	1	197099114	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25228	197099114	52151507	334	4728										
ASPM	259266	broad.mit.edu	37	chr1	197111684	197111684	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgagcaactgaagctgttgtCgaagagggtgttacctcgtt	13	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197111684C>T	ENST00000367409.4	-	3	1954	c.1698G>A	c.(1696-1698)tcG>tcA	p.S566S	ASPM_ENST00000294732.7_Silent_p.S566S	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	566					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						AAGCTGTTGTCGAAGAGGGTG	0.348													20	50					0	0	1	0	0	T	197111684	C	T	197111684	2	4	48	1	0	0	0	0	0	0	0	1	1055	871	31	1		1	ASPM	1	197111684	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12570	197111684	52138937	335	4729										
ZBTB41	360023	broad.mit.edu	37	chr1	197128599	197128599	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctagcatttgttcaggtcGaactgggtgaactatatttg	10	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197128599G>A	ENST00000367405.4	-	10	2688	c.2620C>T	c.(2620-2622)Cga>Tga	p.R874*	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	874					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						TGTTCAGGTCGAACTGGGTGA	0.408													38	98					0	0	1	0	0	A	197128599	G	A	197128599	4	1	48	1	0	0	0	0	0	1	0	0	17601	1066	37	1	113	1	ZBTB41	1	197128599	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16915	197128599	52122022	336	4730										
CRB1	23418	broad.mit.edu	37	chr1	197390754	197390754	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcgaaagctcctactccacTtgaaagtgatcaatcaatat	6	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197390754T>C	ENST00000367400.3	+	6	1931	c.1796T>C	c.(1795-1797)cTt>cCt	p.L599P	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.L487P|CRB1_ENST00000543483.1_Intron|CRB1_ENST00000535699.1_Missense_Mutation_p.L530P|CRB1_ENST00000538660.1_Missense_Mutation_p.L599P|CRB1_ENST00000544212.1_Missense_Mutation_p.L80P	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	599	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCTACTCCACTTGAAAGTGAT	0.438													27	72					0	0	1	0	0	C	197390754	T	C	197390754	3	2	48	1	0	0	0	0	1	0	0	0	3871	1609	56	4	1818	4	CRB1	1	197390754	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	262155	197390754	51859867	337	4731										
CRB1	23418	broad.mit.edu	37	chr1	197446978	197446978	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtggaaatgtggaacttgaTgccaccccctgcaatggaga	12	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197446978T>C	ENST00000367400.3	+	12	4325	c.4190T>C	c.(4189-4191)aTg>aCg	p.M1397T	CRB1_ENST00000367399.2_Missense_Mutation_p.M1285T|CRB1_ENST00000535699.1_Missense_Mutation_p.M1373T|CRB1_ENST00000538660.1_Missense_Mutation_p.M861T|CRB1_ENST00000544212.1_Missense_Mutation_p.M878T	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1397					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGGAACTTGATGCCACCCCCT	0.522													26	41					0	0	1	0	0	C	197446978	T	C	197446978	3	2	48	1	0	0	0	0	1	0	0	0	3871	1464	51	4	4236	4	CRB1	1	197446978	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	56224	197446978	51803643	338	4732										
DENND1B	163486	broad.mit.edu	37	chr1	197704925	197704925	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcagataagctggactgtcCtctacagaaagaagcacaaa	10	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:197704925C>A	ENST00000235453.4	-	0	120				DENND1B_ENST00000367396.3_Intron|DENND1B_ENST00000477581.1_5'UTR			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						CTGGACTGTCCTCTACAGAAA	0.468													9	23					1.12685e-05	1.24509e-05	1	1	0	A	197704925	C	A	197704925	1	1	48	1	0	0	0	0	0	0	0	0	4455	696	24	5		5	DENND1B	1	197704925	Translation_Start_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	257947	197704925	51545696	339	4733										
NEK7	140609	broad.mit.edu	37	chr1	198231762	198231762	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatcaaagaaatagatcttCttaaggtaattaatgaactg	7	5	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:198231762C>A	ENST00000367385.4	+	4	598	c.256C>A	c.(256-258)Ctt>Att	p.L86I	NEK7_ENST00000538004.1_Missense_Mutation_p.L86I	NM_133494.2	NP_598001.1	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	86	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21						AATAGATCTTCTTAAGGTAAT	0.279													20	41					4.54149e-19	6.16979e-19	1	1	0	A	198231762	C	A	198231762	3	1	48	1	0	0	0	0	1	0	0	0	10375	913	32	2	266	2	NEK7	1	198231762	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	526837	198231762	51018859	340	4734										
PTPRC	5788	broad.mit.edu	37	chr1	198682092	198682092	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttaacaggtccaggagaGcctcagattattttttgtag	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:198682092G>A	ENST00000367376.2	+	12	1347	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E	PTPRC_ENST00000352140.3_Silent_p.E344E|PTPRC_ENST00000594404.1_Silent_p.E231E|PTPRC_ENST00000442510.2_Silent_p.E394E|PTPRC_ENST00000348564.6_Silent_p.E233E	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	392	Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GTCCAGGAGAGCCTCAGATTA	0.318													16	39					0	0	1	0	0	A	198682092	G	A	198682092	2	1	48	1	0	0	0	0	0	0	0	1	12848	962	34	3		3	PTPRC	1	198682092	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	450330	198682092	50568529	341	4735										
NR5A2	2494	broad.mit.edu	37	chr1	200017907	200017907	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaactctcttctccattgtCgagtgggccaggagtagtat	10	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:200017907C>T	ENST00000367362.3	+	5	1317	c.1071C>T	c.(1069-1071)gtC>gtT	p.V357V	NR5A2_ENST00000544748.1_Silent_p.V285V|NR5A2_ENST00000236914.3_Silent_p.V311V	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	357	Ligand-binding.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					TCTCCATTGTCGAGTGGGCCA	0.458													43	82					0	0	1	0	0	T	200017907	C	T	200017907	2	4	48	1	0	0	0	0	0	0	0	1	10683	871	31	1		1	NR5A2	1	200017907	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1335815	200017907	49232714	342	4736										
CACNA1S	779	broad.mit.edu	37	chr1	201046078	201046078	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgatgagggcttggggaaaGttgtcaaagttgctgcgccg	16	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:201046078G>A	ENST00000362061.3	-	12	2023	c.1797C>T	c.(1795-1797)aaC>aaT	p.N599N	CACNA1S_ENST00000367338.3_Silent_p.N599N	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	599					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTTGGGGAAAGTTGTCAAAGT	0.532													40	95					0	0	1	0	0	A	201046078	G	A	201046078	2	1	48	1	0	0	0	0	0	0	0	1	2565	1020	36	3		3	CACNA1S	1	201046078	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1028171	201046078	48204543	343	4737										
IGFN1	91156	broad.mit.edu	37	chr1	201185815	201185815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagtataccttccgagtgCgggctgtgacctcagagggg	16	9	1	2	rs35669472		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:201185815C>T	ENST00000335211.4	+	16	9659	c.9529C>T	c.(9529-9531)Cgg>Tgg	p.R3177W	IGFN1_ENST00000295591.8_Missense_Mutation_p.R337W	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1									p.R3177W(2)|p.R337W(2)		autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTTCCGAGTGCGGGCTGTGAC	0.647													26	59					0	0	1	0	0	T	201185815	C	T	201185815	3	4	48	1	0	0	0	0	1	0	0	0	7633	759	27	1	9587	1	IGFN1	1	201185815	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	139737	201185815	48064806	344	4738										
SHISA4	149345	broad.mit.edu	37	chr1	201860581	201860581	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccagtatacccatacccCcaggaccccaaagctggccc	7	19	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:201860581C>A	ENST00000362011.6	+	4	719	c.432C>A	c.(430-432)ccC>ccA	p.P144P	SHISA4_ENST00000464117.1_3'UTR	NM_198149.2	NP_937792.2	Q96DD7	SHSA4_HUMAN	shisa family member 4	144	Pro-rich.					integral to membrane				kidney(1)|lung(4)	5						ACCCATACCCCCAGGACCCCA	0.587													62	81					1.95512e-22	2.71716e-22	1	1	0	A	201860581	C	A	201860581	2	1	48	1	0	0	0	0	0	0	0	1	14336	610	22	5		5	SHISA4	1	201860581	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	674766	201860581	47390040	345	4739										
LGR6	59352	broad.mit.edu	37	chr1	202278292	202278292	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccttctccaaggacagttTcccaaaactgaggtgaggga	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:202278292T>C	ENST00000367278.3	+	15	1483	c.1394T>C	c.(1393-1395)tTc>tCc	p.F465S	LGR6_ENST00000255432.7_Missense_Mutation_p.F413S|LGR6_ENST00000439764.2_Missense_Mutation_p.F326S	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	465						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						AAGGACAGTTTCCCAAAACTG	0.587													25	43					0	0	1	0	0	C	202278292	T	C	202278292	3	2	48	1	0	0	0	0	1	0	0	0	8797	1783	62	4	1599	4	LGR6	1	202278292	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	417711	202278292	46972329	346	4740										
KDM5B	10765	broad.mit.edu	37	chr1	202711856	202711856	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcatcctgtgtgactaggcGaaggtgtcgcaaaagatcat	12	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:202711856G>A	ENST00000367265.3	-	17	3565	c.2401C>T	c.(2401-2403)Cgc>Tgc	p.R801C	KDM5B_ENST00000367264.2_Missense_Mutation_p.R837C	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	801					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GTGACTAGGCGAAGGTGTCGC	0.443													38	79					0	0	1	0	0	A	202711856	G	A	202711856	3	1	48	1	0	0	0	0	1	0	0	0	8176	1058	37	1	2277	1	KDM5B	1	202711856	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	433564	202711856	46538765	347	4741										
TMEM183A	92703	broad.mit.edu	37	chr1	202985262	202985262	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccccagcacattaaagaaTtccaaagtaagtgagaattt	6	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:202985262T>G	ENST00000367242.3	+	5	782	c.702T>G	c.(700-702)aaT>aaG	p.N234K	TMEM183A_ENST00000468449.1_3'UTR	NM_001079809.1|NM_138391.4	NP_001073277.1|NP_612400.3			transmembrane protein 183A											endometrium(1)|large_intestine(2)|lung(1)|skin(3)	7			BRCA - Breast invasive adenocarcinoma(75;0.18)			CATTAAAGAATTCCAAAGTAA	0.458													49	68					0	0	1	0	0	G	202985262	T	G	202985262	3	3	48	1	0	0	0	0	1	0	0	0	16161	1490	52	4	720	4	TMEM183A	1	202985262	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	273406	202985262	46265359	348	4742										
CHIT1	1118	broad.mit.edu	37	chr1	203188819	203188819	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggccagcatccctccttcCttggtgaaggggcctggagt	13	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:203188819C>A	ENST00000367229.1	-	8	922	c.888G>T	c.(886-888)aaG>aaT	p.K296N	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Missense_Mutation_p.K277N|CHIT1_ENST00000535569.1_Missense_Mutation_p.K287N	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	296					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TCCCTCCTTCCTTGGTGAAGG	0.587													24	49					2.70639e-06	3.02606e-06	1	1	0	A	203188819	C	A	203188819	3	1	48	1	0	0	0	0	1	0	0	0	3368	680	24	5	528	5	CHIT1	1	203188819	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	203557	203188819	46061802	349	4743										
ATP2B4	493	broad.mit.edu	37	chr1	203691694	203691694	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accattgtttttaacaccttCgtgctgatgcagctcttcaa	6	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:203691694C>T	ENST00000357681.5	+	18	4024	c.2901C>T	c.(2899-2901)ttC>ttT	p.F967F	ATP2B4_ENST00000391954.2_Silent_p.F967F|ATP2B4_ENST00000367218.3_Silent_p.F967F|ATP2B4_ENST00000367219.3_Silent_p.F955F|ATP2B4_ENST00000341360.2_Silent_p.F967F	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	967					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TTAACACCTTCGTGCTGATGC	0.448													25	58					0	0	1	0	0	T	203691694	C	T	203691694	2	4	48	1	0	0	0	0	0	0	0	1	1141	883	31	1		1	ATP2B4	1	203691694	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	502875	203691694	45558927	350	4744										
ZC3H11A	9877	broad.mit.edu	37	chr1	203799314	203799314	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaaagaaaatgaaggaaaAatctaagaagcaaggtggta	11	3	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:203799314A>C	ENST00000545588.1	+	7	4510	c.683A>C	c.(682-684)aAa>aCa	p.K228T	ZC3H11A_ENST00000367212.3_Missense_Mutation_p.K228T|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.K228T|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.K228T|ZC3H11A_ENST00000367214.1_Missense_Mutation_p.K228T	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	228							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGAAGGAAAAATCTAAGAAG	0.348													38	62					0	0	1	0	0	C	203799314	A	C	203799314	3	2	48	1	0	0	0	0	1	0	0	0	17618	14	1	4	705	4	ZC3H11A	1	203799314	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	107620	203799314	45451307	351	4745										
PPP1R15B	84919	broad.mit.edu	37	chr1	204379610	204379610	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaggggtgggtaaatcttgCcccttgttagcctgttgaag	13	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:204379610C>T	ENST00000367188.4	-	1	1309	c.930G>A	c.(928-930)ggG>ggA	p.G310G	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	310					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			GTAAATCTTGCCCCTTGTTAG	0.522													27	191					0	0	1	0	0	T	204379610	C	T	204379610	2	4	48	1	0	0	0	0	0	0	0	1	12412	726	26	3		3	PPP1R15B	1	204379610	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	580296	204379610	44871011	352	4746										
PIK3C2B	5287	broad.mit.edu	37	chr1	204438067	204438067	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgccatagcgggaggcataGgtgcgggggggcacctgagg	20	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:204438067G>T	ENST00000367187.3	-	3	1420	c.864C>A	c.(862-864)acC>acA	p.T288T	PIK3C2B_ENST00000424712.2_Silent_p.T288T	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	288	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGGAGGCATAGGTGCGGGGGG	0.617													47	96					3.77016e-25	5.30521e-25	1	1	0	T	204438067	G	T	204438067	2	4	48	1	0	0	0	0	0	0	0	1	11957	987	35	5		5	PIK3C2B	1	204438067	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58457	204438067	44812554	353	4747										
SLC45A3	85414	broad.mit.edu	37	chr1	205632665	205632665	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcccagatgaagggccggCggcggccatagcgtccacgc	16	14	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:205632665C>T	ENST00000367145.3	-	3	549	c.254G>A	c.(253-255)cGc>cAc	p.R85H		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	85					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			GAAGGGCCGGCGGCGGCCATA	0.647			T	"ETV1, ETV5, ELK4, ERG"	prostate								12	35					0	0	1	0	0	T	205632665	C	T	205632665	3	4	48	1	0	0	0	0	1	0	0	0	14696	768	27	1	1419	1	SLC45A3	1	205632665	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1194598	205632665	43617956	354	4748										
C4BPA	722	broad.mit.edu	37	chr1	207297270	207297270	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatctatcttattcagattTttcttaattggctcaaccac	4	9	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:207297270T>G	ENST00000367070.3	+	5	626	c.432T>G	c.(430-432)ttT>ttG	p.F144L		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	144	Sushi 2.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TATTCAGATTTTTCTTAATTG	0.343													8	7					0	0	1	0	0	G	207297270	T	G	207297270	3	3	48	1	0	0	0	0	1	0	0	0	2264	1838	64	4	446	4	C4BPA	1	207297270	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1664605	207297270	41953351	355	4749										
CD55	1604	broad.mit.edu	37	chr1	207495831	207495831	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtacaaatgtgaagaaagcTttgtgaaaattcctggcgag	11	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:207495831T>G	ENST00000367064.3	+	2	463	c.205T>G	c.(205-207)Ttt>Gtt	p.F69V	CD55_ENST00000314754.8_Missense_Mutation_p.F69V|CD55_ENST00000367065.5_Missense_Mutation_p.F69V|CD55_ENST00000391920.4_Missense_Mutation_p.F69V|CD55_ENST00000391921.4_Missense_Mutation_p.F69V|CD55_ENST00000367067.4_Missense_Mutation_p.F69V|CD55_ENST00000367062.4_Missense_Mutation_p.F69V|CD55_ENST00000367063.2_Missense_Mutation_p.F69V	NM_000574.3	NP_000565.1	P08174	DAF_HUMAN	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	69	Sushi 1.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16					Chloramphenicol(DB00446)	TGAAGAAAGCTTTGTGAAAAT	0.448													11	49					0	0	1	0	0	G	207495831	T	G	207495831	3	3	48	1	0	0	0	0	1	0	0	0	3046	1609	56	4	211	4	CD55	1	207495831	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	198561	207495831	41754790	356	4750										
CR2	1380	broad.mit.edu	37	chr1	207648459	207648459	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcccacaatgacatagtgTatgttgactgcaatcctggc	8	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:207648459T>C	ENST00000367057.3	+	14	2803	c.2614T>C	c.(2614-2616)Tat>Cat	p.Y872H	CR2_ENST00000458541.2_Missense_Mutation_p.Y786H|CR2_ENST00000367058.3_Missense_Mutation_p.Y813H|CR2_ENST00000367059.3_Missense_Mutation_p.Y813H	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	938	Sushi 14.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGACATAGTGTATGTTGACTG	0.438													40	53					0	0	1	0	0	C	207648459	T	C	207648459	3	2	48	1	0	0	0	0	1	0	0	0	3865	1638	57	4	2668	4	CR2	1	207648459	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	152628	207648459	41602162	357	4751										
PLXNA2	5362	broad.mit.edu	37	chr1	208269408	208269408	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagttgtaaaacttgaactCggtgctgacaaatatcttcc	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:208269408C>T	ENST00000367033.3	-	8	2705	c.1948G>A	c.(1948-1950)Gag>Aag	p.E650K		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	650					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		AACTTGAACTCGGTGCTGACA	0.483													115	254					0	0	1	0	0	T	208269408	C	T	208269408	3	4	48	1	0	0	0	0	1	0	0	0	12167	893	31	1	3836	1	PLXNA2	1	208269408	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	620949	208269408	40981213	358	4752										
LAMB3	3914	broad.mit.edu	37	chr1	209799080	209799080	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctcggatctgctcaatcTtactctttgcatctaggatc	7	12	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:209799080T>G	ENST00000391911.1	-	13	2278	c.1889A>C	c.(1888-1890)aAg>aCg	p.K630T	LAMB3_ENST00000356082.4_Missense_Mutation_p.K630T|LAMB3_ENST00000367030.3_Missense_Mutation_p.K630T	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	630	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTGCTCAATCTTACTCTTTGC	0.612													31	65					0	0	1	0	0	G	209799080	T	G	209799080	3	3	48	1	0	0	0	0	1	0	0	0	8650	1609	56	4	1669	4	LAMB3	1	209799080	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1529672	209799080	39451541	359	4753										
LAMB3	3914	broad.mit.edu	37	chr1	209803245	209803245	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggggtcaaagtgacatgtCtctgagtgcccattgcagtc	13	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:209803245C>A	ENST00000391911.1	-	9	1358	c.969G>T	c.(967-969)gaG>gaT	p.E323D	LAMB3_ENST00000356082.4_Missense_Mutation_p.E323D|LAMB3_ENST00000367030.3_Missense_Mutation_p.E323D	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	323	Laminin EGF-like 2.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity	p.E323D(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGTGACATGTCTCTGAGTGCC	0.557													29	57					1.39806e-14	1.82523e-14	1	1	0	A	209803245	C	A	209803245	3	1	48	1	0	0	0	0	1	0	0	0	8650	912	32	2	2605	2	LAMB3	1	209803245	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4165	209803245	39447376	360	4754										
TRAF3IP3	80342	broad.mit.edu	37	chr1	209933532	209933532	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccaggtggggaagacgctgAggatccaacagagagagcag	17	8	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:209933532A>G	ENST00000367024.1	+	3	664	c.148A>G	c.(148-150)Agg>Ggg	p.R50G	TRAF3IP3_ENST00000010338.4_Missense_Mutation_p.R50G|TRAF3IP3_ENST00000367025.3_Missense_Mutation_p.R50G|TRAF3IP3_ENST00000400959.3_Missense_Mutation_p.R50G|TRAF3IP3_ENST00000367026.3_Missense_Mutation_p.R50G			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	50						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GAAGACGCTGAGGATCCAACA	0.597													14	31					0	0	1	0	0	G	209933532	A	G	209933532	3	3	48	1	0	0	0	0	1	0	0	0	16502	295	11	4	150	4	TRAF3IP3	1	209933532	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	130287	209933532	39317089	361	4755										
IRF6	3664	broad.mit.edu	37	chr1	209974599	209974599	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttaccttaaaaatggtatTttcctcttcttgttgagggc	7	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:209974599T>G	ENST00000367021.3	-	3	332	c.160A>C	c.(160-162)Aat>Cat	p.N54H	IRF6_ENST00000542854.1_Intron	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	54					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		AAAATGGTATTTTCCTCTTCT	0.428										HNSCC(57;0.16)			38	67					0	0	1	0	0	G	209974599	T	G	209974599	3	3	48	1	0	0	0	0	1	0	0	0	7877	1841	64	4	1271	4	IRF6	1	209974599	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	41067	209974599	39276022	362	4756										
SYT14	255928	broad.mit.edu	37	chr1	210187141	210187141	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaattcacaagataaaatTtgtaagtatcgtattgctgc	7	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:210187141T>G	ENST00000537238.1	+	4	502	c.112_splice	c.e4+1	p.I37_splice	SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000422431.1_Splice_Site_p.I120_splice|SYT14_ENST00000367019.1_Splice_Site_p.I75_splice|SYT14_ENST00000367015.1_Splice_Site_p.I37_splice|SYT14_ENST00000534859.1_Splice_Site_p.I75_splice|SYT14_ENST00000399639.2_Splice_Site_p.I75_splice|SYT14_ENST00000472886.1_Splice_Site_p.I75_splice	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	75						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		AAGATAAAATTTGTAAGTATC	0.294													6	57					0	0	1	0	0	G	210187141	T	G	210187141	5	3	48	1	0	0	0	0	0	0	1	0	15526	1855	64	4	374	4	SYT14	1	210187141	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	212542	210187141	39063480	363	4757										
SYT14	255928	broad.mit.edu	37	chr1	210267762	210267762	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttctccccatctgtcatgtAcaccctcagaaattggggac	8	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:210267762A>G	ENST00000537238.1	+	6	815	c.424A>G	c.(424-426)Aca>Gca	p.T142A	SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000422431.1_Missense_Mutation_p.T225A|SYT14_ENST00000367019.1_Missense_Mutation_p.T180A|SYT14_ENST00000367015.1_Missense_Mutation_p.T142A|SYT14_ENST00000534859.1_Missense_Mutation_p.T180A|SYT14_ENST00000399639.2_Missense_Mutation_p.T180A|SYT14_ENST00000472886.1_Missense_Mutation_p.T180A	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	180						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		TCTGTCATGTACACCCTCAGA	0.473													21	44					0	0	1	0	0	G	210267762	A	G	210267762	3	3	48	1	0	0	0	0	1	0	0	0	15526	391	14	4	695	4	SYT14	1	210267762	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	80621	210267762	38982859	364	4758										
NEK2	4751	broad.mit.edu	37	chr1	211847747	211847747	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aataatccgatcatagtaacGaacgatgtttggatgtttca	8	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:211847747G>A	ENST00000366999.4	-	2	343	c.205C>T	c.(205-207)Cgt>Tgt	p.R69C	NEK2_ENST00000366998.3_Missense_Mutation_p.R69C|NEK2_ENST00000540251.1_Missense_Mutation_p.R26C	NM_002497.3	NP_002488.1	P51955	NEK2_HUMAN	NIMA-related kinase 2	69	Protein kinase.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		TCATAGTAACGAACGATGTTT	0.403													12	21					0	0	1	0	0	A	211847747	G	A	211847747	3	1	48	1	0	0	0	0	1	0	0	0	10370	1058	37	1	1160	1	NEK2	1	211847747	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1579985	211847747	37402874	365	4759										
ATF3	467	broad.mit.edu	37	chr1	212792760	212792760	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagattgaggagctcaagAacgagaagcagcatttgata	11	7	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:212792760A>C	ENST00000341491.4	+	4	674	c.409A>C	c.(409-411)Aac>Cac	p.N137H	ATF3_ENST00000366987.2_Missense_Mutation_p.N137H|ATF3_ENST00000366985.1_Missense_Mutation_p.N80H|ATF3_ENST00000492118.1_3'UTR|ATF3_ENST00000366983.1_3'UTR	NM_001040619.2|NM_001206488.2|NM_001674.3	NP_001035709.1|NP_001193417.2|NP_001665.1	P18847	ATF3_HUMAN	activating transcription factor 3	137	Leucine-zipper.					nucleolus	identical protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6				OV - Ovarian serous cystadenocarcinoma(81;0.00628)|all cancers(67;0.0097)|GBM - Glioblastoma multiforme(131;0.0388)|Epithelial(68;0.0933)		GGAGCTCAAGAACGAGAAGCA	0.502													40	65					0	0	1	0	0	C	212792760	A	C	212792760	3	2	48	1	0	0	0	0	1	0	0	0	1080	246	9	4	483	4	ATF3	1	212792760	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	945013	212792760	36457861	366	4760										
FLVCR1	28982	broad.mit.edu	37	chr1	213062579	213062579	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctctgtgtctggatgtTtataggcatcatattaacag	8	6	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:213062579T>G	ENST00000366971.4	+	8	1703	c.1505T>G	c.(1504-1506)tTt>tGt	p.F502C	FLVCR1_ENST00000483790.1_3'UTR	NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	502					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		GTCTGGATGTTTATAGGCATC	0.368													11	49					0	0	1	0	0	G	213062579	T	G	213062579	3	3	48	1	0	0	0	0	1	0	0	0	5977	1841	64	4	1535	4	FLVCR1	1	213062579	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	269819	213062579	36188042	367	4761										
RPS6KC1	26750	broad.mit.edu	37	chr1	213414614	213414614	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatcaaaaaatagccccatgGaattctttaggatagacagt	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:213414614G>T	ENST00000366960.3	+	11	1945	c.1795G>T	c.(1795-1797)Gaa>Taa	p.E599*	RPS6KC1_ENST00000543470.1_Nonsense_Mutation_p.E387*|RPS6KC1_ENST00000366959.3_Nonsense_Mutation_p.E587*|RPS6KC1_ENST00000543354.1_Nonsense_Mutation_p.E302*|RPS6KC1_ENST00000490299.1_3'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	599					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TAGCCCCATGGAATTCTTTAG	0.418													17	27					0.000566183	0.00059967	1	1	0	T	213414614	G	T	213414614	4	4	48	1	0	0	0	0	0	1	0	0	13709	1175	41	2	1837	2	RPS6KC1	1	213414614	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	352035	213414614	35836007	368	4762										
PROX1	5629	broad.mit.edu	37	chr1	214171528	214171528	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagcaccgccgaagggctCtccttgtcgctcataaagtc	9	16	2	0	rs35176368		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:214171528C>A	ENST00000366958.4	+	2	2258	c.1650C>A	c.(1648-1650)ctC>ctA	p.L550L	PROX1_ENST00000498508.2_Silent_p.L550L|PROX1_ENST00000435016.1_Silent_p.L550L|PROX1_ENST00000261454.4_Silent_p.L550L	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	550					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CCGAAGGGCTCTCCTTGTCGC	0.517													38	83					2.2871e-25	3.22072e-25	1	1	0	A	214171528	C	A	214171528	2	1	48	1	0	0	0	0	0	0	0	1	12611	900	32	2		2	PROX1	1	214171528	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	756914	214171528	35079093	369	4763										
KCTD3	51133	broad.mit.edu	37	chr1	215751415	215751415	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctttttcatggttacttgCccccaccaggtattttcact	5	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:215751415C>T	ENST00000259154.4	+	6	682	c.388C>T	c.(388-390)Ccc>Tcc	p.P130S		NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	130						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TGGTTACTTGCCCCCACCAGG	0.343													8	60					0	0	1	0	0	T	215751415	C	T	215751415	3	4	48	1	0	0	0	0	1	0	0	0	8153	739	26	3	410	3	KCTD3	1	215751415	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1579887	215751415	33499206	370	4764										
KCTD3	51133	broad.mit.edu	37	chr1	215793542	215793542	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttccagactattaatttgaAcagaaatgtagaaagagctg	8	6	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:215793542A>C	ENST00000259154.4	+	18	2324	c.2030A>C	c.(2029-2031)aAc>aCc	p.N677T	KCTD3_ENST00000495537.1_3'UTR	NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	677						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		ATTAATTTGAACAGAAATGTA	0.418													26	28					0	0	1	0	0	C	215793542	A	C	215793542	3	2	48	1	0	0	0	0	1	0	0	0	8153	43	2	4	2100	4	KCTD3	1	215793542	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	42127	215793542	33457079	371	4765										
USH2A	7399	broad.mit.edu	37	chr1	215802207	215802207	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagtgagttgtccatcaaGactttcttgtcttgaatgtc	8	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:215802207G>T	ENST00000366943.2	-	72	15926	c.15540C>A	c.(15538-15540)gtC>gtA	p.V5180V	USH2A_ENST00000307340.3_Silent_p.V5156V			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5156					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTCCATCAAGACTTTCTTGT	0.502										HNSCC(13;0.011)			33	51					6.90743e-12	8.65044e-12	1	1	0	T	215802207	G	T	215802207	2	4	48	1	0	0	0	0	0	0	0	1	17095	929	33	2		2	USH2A	1	215802207	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8665	215802207	33448414	372	4766										
USH2A	7399	broad.mit.edu	37	chr1	215820898	215820898	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaaactgatccactcggaAgccgtactgcccacctcgtt	9	14	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:215820898A>C	ENST00000366943.2	-	67	15143	c.14757T>G	c.(14755-14757)gcT>gcG	p.A4919A	USH2A_ENST00000307340.3_Silent_p.A4919A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4919	Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCACTCGGAAGCCGTACTGC	0.547										HNSCC(13;0.011)			4	56					0	0	1	0	0	C	215820898	A	C	215820898	2	2	48	1	0	0	0	0	0	0	0	1	17095	59	3	4		4	USH2A	1	215820898	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	18691	215820898	33429723	373	4767										
ESRRG	2104	broad.mit.edu	37	chr1	216680421	216680421	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcagcatcttgccagctcGacgagggtcttccatgtgct	10	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:216680421G>A	ENST00000391890.3	-	9	1706	c.1189C>T	c.(1189-1191)Cga>Tga	p.R397*	ESRRG_ENST00000408911.3_Nonsense_Mutation_p.R413*|ESRRG_ENST00000366938.2_Nonsense_Mutation_p.R390*|ESRRG_ENST00000360012.3_Nonsense_Mutation_p.R390*|ESRRG_ENST00000487276.1_Nonsense_Mutation_p.R390*|ESRRG_ENST00000493748.1_Nonsense_Mutation_p.R390*|ESRRG_ENST00000463665.1_Nonsense_Mutation_p.R351*|ESRRG_ENST00000366940.2_Nonsense_Mutation_p.R390*|ESRRG_ENST00000359162.2_Nonsense_Mutation_p.R390*|ESRRG_ENST00000366937.1_Nonsense_Mutation_p.R425*|ESRRG_ENST00000493603.1_Nonsense_Mutation_p.R390*|ESRRG_ENST00000361525.3_Nonsense_Mutation_p.R390*|ESRRG_ENST00000361395.2_Nonsense_Mutation_p.R390*	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	413					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TTGCCAGCTCGACGAGGGTCT	0.502													18	34					0	0	1	0	0	A	216680421	G	A	216680421	4	1	48	1	0	0	0	0	0	1	0	0	5290	1066	37	1	143	1	ESRRG	1	216680421	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	859523	216680421	32570200	374	4768										
RRP15	51018	broad.mit.edu	37	chr1	218475894	218475894	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaagaaagactagagaaaaTaaaacaggtatgttccacca	8	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:218475894T>G	ENST00000366932.3	+	2	428	c.398T>G	c.(397-399)aTa>aGa	p.I133R	RRP15_ENST00000491428.1_3'UTR	NM_016052.3	NP_057136.2	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog (S. cerevisiae)	133						mitochondrion|nucleolus	protein binding		ACBD6/RRP15(2)	NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		CTAGAGAAAATAAAACAGGTA	0.348													8	110					0	0	1	0	0	G	218475894	T	G	218475894	3	3	48	1	0	0	0	0	1	0	0	0	13738	1406	49	4	404	4	RRP15	1	218475894	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1795473	218475894	30774727	375	4769										
RAB3GAP2	25782	broad.mit.edu	37	chr1	220386308	220386308	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatcactatatttccattTtgctgtaagaattaagatat	4	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:220386308T>C	ENST00000358951.2	-	4	423	c.307A>G	c.(307-309)Aaa>Gaa	p.K103E		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	103					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		TATTTCCATTTTGCTGTAAGA	0.299													14	14					0	0	1	0	0	C	220386308	T	C	220386308	3	2	48	1	0	0	0	0	1	0	0	0	12987	1850	64	4	4002	4	RAB3GAP2	1	220386308	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1910414	220386308	28864313	376	4770										
DUSP10	11221	broad.mit.edu	37	chr1	221879708	221879708	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgggctgaggtagcaagctCgaggccgcggatgcgccgcc	17	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:221879708C>T	ENST00000366899.3	-	3	1150	c.912G>A	c.(910-912)tcG>tcA	p.S304S	DUSP10_ENST00000323825.3_5'UTR|DUSP10_ENST00000544095.1_5'UTR|DUSP10_ENST00000468085.1_5'UTR	NM_007207.4	NP_009138.1	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10	304					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			NS(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(131;0.0103)		GTAGCAAGCTCGAGGCCGCGG	0.592													50	98					0	0	1	0	0	T	221879708	C	T	221879708	2	4	48	1	0	0	0	0	0	0	0	1	4836	871	31	1		1	DUSP10	1	221879708	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1493400	221879708	27370913	377	4771										
HHIPL2	79802	broad.mit.edu	37	chr1	222696106	222696106	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattcttgctgcttgtaggaGaagccagcttcttggaggag	13	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:222696106G>T	ENST00000343410.6	-	9	2070	c.2012C>A	c.(2011-2013)tCt>tAt	p.S671Y	HHIPL2_ENST00000473144.1_5'UTR	NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	671					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		GCTTGTAGGAGAAGCCAGCTT	0.532													88	165					3.49128e-24	4.89562e-24	1	1	0	T	222696106	G	T	222696106	3	4	48	1	0	0	0	0	1	0	0	0	7134	942	33	2	166	2	HHIPL2	1	222696106	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	816398	222696106	26554515	378	4772										
DISP1	84976	broad.mit.edu	37	chr1	223177256	223177256	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaactgagaaaccaaacattCttttaccagactgatgaaca	5	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:223177256C>A	ENST00000284476.6	+	8	2681	c.2517C>A	c.(2515-2517)ttC>ttA	p.F839L		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	839					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		ACCAAACATTCTTTTACCAGA	0.453													15	45					6.31663e-08	7.35827e-08	1	1	0	A	223177256	C	A	223177256	3	1	48	1	0	0	0	0	1	0	0	0	4567	912	32	2	2543	2	DISP1	1	223177256	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	481150	223177256	26073365	379	4773										
TLR5	7100	broad.mit.edu	37	chr1	223285114	223285114	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggttcgctgtaaggttgatCtttggcaaagtcactagttt	11	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:223285114C>A	ENST00000540964.1	-	4	1721	c.1260G>T	c.(1258-1260)aaG>aaT	p.K420N	TLR5_ENST00000342210.6_Missense_Mutation_p.K420N			O60602	TLR5_HUMAN	toll-like receptor 5	420			Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		TAAGGTTGATCTTTGGCAAAG	0.408													29	62					1.2476e-16	1.66396e-16	1	1	0	A	223285114	C	A	223285114	3	1	48	1	0	0	0	0	1	0	0	0	16013	912	32	2	1320	2	TLR5	1	223285114	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	107858	223285114	25965507	380	4774										
SUSD4	55061	broad.mit.edu	37	chr1	223402693	223402693	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaggccgcgggtggcagacGaaatctccgtgactcaccat	12	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:223402693G>T	ENST00000343846.3	-	5	1395	c.762C>A	c.(760-762)ttC>ttA	p.F254L	SUSD4_ENST00000366878.4_Missense_Mutation_p.F254L|SUSD4_ENST00000454695.2_Missense_Mutation_p.F94L|SUSD4_ENST00000478605.1_Intron			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	254	Sushi 4.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GGTGGCAGACGAAATCTCCGT	0.527													20	24					2.94398e-08	3.45884e-08	1	1	0	T	223402693	G	T	223402693	3	4	48	1	0	0	0	0	1	0	0	0	15465	1049	37	2	726	2	SUSD4	1	223402693	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	117579	223402693	25847928	381	4775										
DEGS1	8560	broad.mit.edu	37	chr1	224377638	224377638	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtagatattcctaccgatTttgagggctggttcttctgt	10	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:224377638T>G	ENST00000323699.4	+	2	608	c.442T>G	c.(442-444)Ttt>Gtt	p.F148V	DEGS1_ENST00000391877.3_Missense_Mutation_p.F148V|DEGS1_ENST00000465848.1_3'UTR	NM_003676.3	NP_003667.1	O15121	DEGS1_HUMAN	delta(4)-desaturase, sphingolipid 1	148					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity			breast(1)|kidney(3)|large_intestine(2)|lung(4)	10	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		TCCTACCGATTTTGAGGGCTG	0.428													16	114					0	0	1	0	0	G	224377638	T	G	224377638	3	3	48	1	0	0	0	0	1	0	0	0	4450	1841	64	4	448	4	DEGS1	1	224377638	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	974945	224377638	24872983	382	4776										
NVL	4931	broad.mit.edu	37	chr1	224482015	224482015	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctaggcatatttctcggtCgaaccttcccgcacgtctca	7	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:224482015C>T	ENST00000281701.6	-	12	1538	c.1279G>A	c.(1279-1281)Gac>Aac	p.D427N	NVL_ENST00000361463.3_Missense_Mutation_p.D321N|NVL_ENST00000469075.1_Missense_Mutation_p.D336N|NVL_ENST00000482491.1_Missense_Mutation_p.D151N|NVL_ENST00000391875.2_Missense_Mutation_p.D321N|NVL_ENST00000340871.4_Missense_Mutation_p.D238N	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	427						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		ATTTCTCGGTCGAACCTTCCC	0.453													20	47					0	0	1	0	0	T	224482015	C	T	224482015	3	4	48	1	0	0	0	0	1	0	0	0	10827	884	31	1	1339	1	NVL	1	224482015	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	104377	224482015	24768606	383	4777										
ITPKB	3707	broad.mit.edu	37	chr1	226924334	226924334	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtaggagagccccttttgtCaatttccatagctgtgggtg	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:226924334C>A	ENST00000429204.1	-	2	1153	c.826G>T	c.(826-828)Gac>Tac	p.D276Y	ITPKB_ENST00000272117.3_Missense_Mutation_p.D276Y|ITPKB_ENST00000366784.1_Missense_Mutation_p.D276Y	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	276							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CCCCTTTTGTCAATTTCCATA	0.587													27	47					6.32553e-13	8.04352e-13	1	1	0	A	226924334	C	A	226924334	3	1	48	1	0	0	0	0	1	0	0	0	7961	826	29	2	2042	2	ITPKB	1	226924334	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2442319	226924334	22326287	384	4778										
WNT9A	7483	broad.mit.edu	37	chr1	228111950	228111950	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtacttaaggttgtctccGcagcccccccactgccaggc	9	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:228111950G>A	ENST00000272164.5	-	3	514	c.504C>T	c.(502-504)tgC>tgT	p.C168C	WNT9A_ENST00000497852.1_Intron	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	168					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				GGTTGTCTCCGCAGCCCCCCC	0.627													73	107					0	0	1	0	0	A	228111950	G	A	228111950	2	1	48	1	0	0	0	0	0	0	0	1	17457	1079	38	1		1	WNT9A	1	228111950	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1187616	228111950	21138671	385	4779										
URB2	9816	broad.mit.edu	37	chr1	229771072	229771072	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggacatcaggagtcagattGaggccatgttccgaggaggg	17	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:229771072G>T	ENST00000258243.2	+	4	848	c.712G>T	c.(712-714)Gag>Tag	p.E238*		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	238						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GAGTCAGATTGAGGCCATGTT	0.602													4	84					0.00909568	0.00935351	1	1	0	T	229771072	G	T	229771072	4	4	48	1	0	0	0	0	0	1	0	0	17084	1291	45	2	722	2	URB2	1	229771072	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1659122	229771072	19479549	386	4780										
URB2	9816	broad.mit.edu	37	chr1	229773496	229773496	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcttcaagcaaacaattaGaaaatcagaacccccagggc	7	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:229773496G>A	ENST00000258243.2	+	4	3272	c.3136G>A	c.(3136-3138)Gaa>Aaa	p.E1046K		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1046						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						CAAACAATTAGAAAATCAGAA	0.483													22	38					0	0	1	0	0	A	229773496	G	A	229773496	3	1	48	1	0	0	0	0	1	0	0	0	17084	943	33	3	3146	3	URB2	1	229773496	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2424	229773496	19477125	387	4781										
CAPN9	10753	broad.mit.edu	37	chr1	230891101	230891101	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaaatcgtgaaaaacccaGaattcattcttggaggggcc	11	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:230891101G>T	ENST00000354537.1	+	2	314	c.232G>T	c.(232-234)Gaa>Taa	p.E78*	CAPN9_ENST00000366666.2_Intron|CAPN9_ENST00000271971.2_Nonsense_Mutation_p.E78*|RP11-99J16__A.2_ENST00000412344.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	78	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GAAAAACCCAGAATTCATTCT	0.537													15	43					1.5739e-10	1.93697e-10	1	1	0	T	230891101	G	T	230891101	4	4	48	1	0	0	0	0	0	1	0	0	2650	943	33	2	238	2	CAPN9	1	230891101	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1117605	230891101	18359520	388	4782										
CAPN9	10753	broad.mit.edu	37	chr1	230907779	230907779	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtaagcttccgaggccagaGaatcgagctcatccgaatcc	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:230907779G>A	ENST00000354537.1	+	7	891	c.809G>A	c.(808-810)aGa>aAa	p.R270K	CAPN9_ENST00000366666.2_Missense_Mutation_p.R207K|CAPN9_ENST00000271971.2_Missense_Mutation_p.R270K|RP11-99J16__A.2_ENST00000412344.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	270	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CGAGGCCAGAGAATCGAGCTC	0.537													10	68					0	0	1	0	0	A	230907779	G	A	230907779	3	1	48	1	0	0	0	0	1	0	0	0	2650	942	33	3	835	3	CAPN9	1	230907779	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16678	230907779	18342842	389	4783										
CAPN9	10753	broad.mit.edu	37	chr1	230928177	230928177	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccacatggcacagaccagCggcaatgggaagctggagtt	13	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:230928177C>T	ENST00000354537.1	+	15	1732	c.1650C>T	c.(1648-1650)agC>agT	p.S550S	CAPN9_ENST00000480004.1_3'UTR|RP11-99J16__A.2_ENST00000452640.1_RNA|CAPN9_ENST00000366666.2_Silent_p.S513S|CAPN9_ENST00000271971.2_Silent_p.S576S|RP11-99J16__A.2_ENST00000428480.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	576	Domain IV.|EF-hand 1.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CACAGACCAGCGGCAATGGGA	0.562													35	96					0	0	1	0	0	T	230928177	C	T	230928177	2	4	48	1	0	0	0	0	0	0	0	1	2650	767	27	1		1	CAPN9	1	230928177	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	20398	230928177	18322444	390	4784										
TTC13	79573	broad.mit.edu	37	chr1	231061365	231061365	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctgtacttcaggcttatAactctcaaaattctgatgta	5	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:231061365A>C	ENST00000366661.4	-	13	1493	c.1486T>G	c.(1486-1488)Tat>Gat	p.Y496D	TTC13_ENST00000414259.1_Missense_Mutation_p.Y443D|TTC13_ENST00000366662.4_Missense_Mutation_p.Y443D	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	496							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TCAGGCTTATAACTCTCAAAA	0.403													31	54					0	0	1	0	0	C	231061365	A	C	231061365	3	2	48	1	0	0	0	0	1	0	0	0	16741	362	13	4	1140	4	TTC13	1	231061365	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	133188	231061365	18189256	391	4785										
SIPA1L2	57568	broad.mit.edu	37	chr1	232619691	232619691	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctttgcaataaaggatccCgatcttgtgctgaaagctca	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:232619691C>T	ENST00000366630.1	-	5	2186	c.1828G>A	c.(1828-1830)Ggg>Agg	p.G610R	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.G610R			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	610	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TAAAGGATCCCGATCTTGTGC	0.428													6	60					0	0	1	0	0	T	232619691	C	T	232619691	3	4	48	1	0	0	0	0	1	0	0	0	14384	652	23	1	3412	1	SIPA1L2	1	232619691	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1558326	232619691	16630930	392	4786										
SIPA1L2	57568	broad.mit.edu	37	chr1	232649870	232649870	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagtaaggacaactaaggaCgaggtcgttacttttcccat	9	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:232649870C>T	ENST00000366630.1	-	2	1574	c.1216G>A	c.(1216-1218)Gtc>Atc	p.V406I	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.V406I			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	406					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CAACTAAGGACGAGGTCGTTA	0.527													58	130					0	0	1	0	0	T	232649870	C	T	232649870	3	4	48	1	0	0	0	0	1	0	0	0	14384	536	19	1	4036	1	SIPA1L2	1	232649870	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30179	232649870	16600751	393	4787										
LYST	1130	broad.mit.edu	37	chr1	235878565	235878565	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaagtgaagcacagtgccGctattggaatagtgggagcc	15	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:235878565G>A	ENST00000389794.3	-	42	9894	c.9720C>T	c.(9718-9720)agC>agT	p.S3240S	LYST_ENST00000473037.1_5'UTR|LYST_ENST00000389793.2_Silent_p.S3240S			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3240	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCACAGTGCCGCTATTGGAAT	0.463													24	37					0	0	1	0	0	A	235878565	G	A	235878565	2	1	48	1	0	0	0	0	0	0	0	1	9173	1078	38	1		1	LYST	1	235878565	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3228695	235878565	13372056	394	4788										
LYST	1130	broad.mit.edu	37	chr1	235972297	235972297	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atattcaatatatgctgctgAaaatttttcagtgctggcaa	7	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:235972297A>G	ENST00000389794.3	-	5	1995	c.1821T>C	c.(1819-1821)ttT>ttC	p.F607F	LYST_ENST00000536965.1_Silent_p.F607F|LYST_ENST00000389793.2_Silent_p.F607F			Q99698	LYST_HUMAN	lysosomal trafficking regulator	607					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TATGCTGCTGAAAATTTTTCA	0.333													37	71					0	0	1	0	0	G	235972297	A	G	235972297	2	3	48	1	0	0	0	0	0	0	0	1	9173	243	9	4		4	LYST	1	235972297	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	93732	235972297	13278324	395	4789										
HEATR1	55127	broad.mit.edu	37	chr1	236734928	236734928	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgttgagcagacaactaaGaattaattgtttggtgtatt	10	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:236734928G>T	ENST00000366582.3	-	27	3880	c.3766C>A	c.(3766-3768)Ctt>Att	p.L1256I	HEATR1_ENST00000366581.2_Missense_Mutation_p.L1175I	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1256					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AGACAACTAAGAATTAATTGT	0.373													8	22					0.000157383	0.000169016	1	1	0	T	236734928	G	T	236734928	3	4	48	1	0	0	0	0	1	0	0	0	7067	942	33	2	2744	2	HEATR1	1	236734928	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	762631	236734928	12515693	396	4790										
HEATR1	55127	broad.mit.edu	37	chr1	236748338	236748338	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttaccactgcagtaatgAcactttcaagcttctttatt	4	11	2	1	rs141347838	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:236748338A>C	ENST00000366582.3	-	17	2342	c.2228T>G	c.(2227-2229)gTc>gGc	p.V743G	HEATR1_ENST00000366581.2_Missense_Mutation_p.V743G	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	743					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGCAGTAATGACACTTTCAAG	0.388													3	27					0	0	1	0	0	C	236748338	A	C	236748338	3	2	48	1	0	0	0	0	1	0	0	0	7067	275	10	4	4322	4	HEATR1	1	236748338	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	13410	236748338	12502283	397	4791										
RYR2	6262	broad.mit.edu	37	chr1	237604646	237604646	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatgtaggggtgagaaaaGaagtagatggcatgggaaca	17	2	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237604646G>T	ENST00000366574.2	+	13	1350	c.1033G>T	c.(1033-1035)Gaa>Taa	p.E345*	RYR2_ENST00000360064.6_Nonsense_Mutation_p.E343*|RYR2_ENST00000542537.1_Nonsense_Mutation_p.E329*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	345					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTGAGAAAAGAAGTAGATGG	0.388													20	40					1.64113e-05	1.80518e-05	1	1	0	T	237604646	G	T	237604646	4	4	48	1	0	0	0	0	0	1	0	0	13820	943	33	2	1083	2	RYR2	1	237604646	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	856308	237604646	11645975	398	4792										
RYR2	6262	broad.mit.edu	37	chr1	237670013	237670013	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttttgtaaattttagatcGtgttgcctcctcatctagaa	6	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237670013G>A	ENST00000366574.2	+	23	2934	c.2617G>A	c.(2617-2619)Gtg>Atg	p.V873M	RYR2_ENST00000360064.6_Missense_Mutation_p.V871M|RYR2_ENST00000542537.1_Missense_Mutation_p.V857M	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	873	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTTTAGATCGTGTTGCCTCC	0.368													8	17					0	0	1	0	0	A	237670013	G	A	237670013	3	1	48	1	0	0	0	0	1	0	0	0	13820	1145	40	1	2707	1	RYR2	1	237670013	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65367	237670013	11580608	399	4793										
RYR2	6262	broad.mit.edu	37	chr1	237756916	237756916	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagttactctaggagatgaAaaaggaaaagtgcatgaaag	11	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237756916A>C	ENST00000366574.2	+	33	4733	c.4416A>C	c.(4414-4416)gaA>gaC	p.E1472D	RYR2_ENST00000360064.6_Missense_Mutation_p.E1470D|RYR2_ENST00000542537.1_Missense_Mutation_p.E1456D	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1472	4 X approximate repeats.|B30.2/SPRY 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAGGAGATGAAAAAGGAAAAG	0.378													17	35					0	0	1	0	0	C	237756916	A	C	237756916	3	2	48	1	0	0	0	0	1	0	0	0	13820	11	1	4	4546	4	RYR2	1	237756916	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	86903	237756916	11493705	400	4794										
RYR2	6262	broad.mit.edu	37	chr1	237870481	237870481	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacagccctgaactcagaGcacatgaacacacttctagg	8	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237870481G>A	ENST00000366574.2	+	68	10130	c.9813G>A	c.(9811-9813)gaG>gaA	p.E3271E	RYR2_ENST00000360064.6_Silent_p.E3269E|RYR2_ENST00000542537.1_Silent_p.E3255E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3271					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGAACTCAGAGCACATGAACA	0.483													15	18					0	0	1	0	0	A	237870481	G	A	237870481	2	1	48	1	0	0	0	0	0	0	0	1	13820	962	34	3		3	RYR2	1	237870481	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	113565	237870481	11380140	401	4795										
RYR2	6262	broad.mit.edu	37	chr1	237895444	237895444	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcggacagctttaacagaGaaatggtatggttgggaggg	16	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237895444G>T	ENST00000366574.2	+	78	11351	c.11034G>T	c.(11032-11034)gaG>gaT	p.E3678D	RYR2_ENST00000360064.6_Missense_Mutation_p.E3676D|RYR2_ENST00000542537.1_Missense_Mutation_p.E3662D	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3678					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTTAACAGAGAAATGGTATG	0.443													8	43					0.000274275	0.000292037	1	1	0	T	237895444	G	T	237895444	3	4	48	1	0	0	0	0	1	0	0	0	13820	933	33	2	11344	2	RYR2	1	237895444	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24963	237895444	11355177	402	4796										
RYR2	6262	broad.mit.edu	37	chr1	237961430	237961430	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggacttcagtgatgccagaGaaaagaagaagccaaagaaa	11	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237961430G>T	ENST00000366574.2	+	97	14367	c.14050G>T	c.(14050-14052)Gaa>Taa	p.E4684*	RYR2_ENST00000360064.6_Nonsense_Mutation_p.E4690*|RYR2_ENST00000542537.1_Nonsense_Mutation_p.E4668*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4684					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGATGCCAGAGAAAAGAAGAA	0.433													7	12					0.0477658	0.0484551	1	1	0	T	237961430	G	T	237961430	4	4	48	1	0	0	0	0	0	1	0	0	13820	943	33	2	14436	2	RYR2	1	237961430	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65986	237961430	11289191	403	4797										
RYR2	6262	broad.mit.edu	37	chr1	237972271	237972271	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtggcattcaattttttccGaaaattctacaataaaagtg	7	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:237972271G>A	ENST00000366574.2	+	100	14686	c.14369G>A	c.(14368-14370)cGa>cAa	p.R4790Q	RYR2_ENST00000360064.6_Missense_Mutation_p.R4796Q|RYR2_ENST00000542537.1_Missense_Mutation_p.R4774Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4790					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R4788Q(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AATTTTTTCCGAAAATTCTAC	0.353													61	103					0	0	1	0	0	A	237972271	G	A	237972271	3	1	48	1	0	0	0	0	1	0	0	0	13820	1058	37	1	14767	1	RYR2	1	237972271	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10841	237972271	11278350	404	4798										
FMN2	56776	broad.mit.edu	37	chr1	240341335	240341335	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccaccatccaaacctcccGatgaggaacacaggctcgag	10	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:240341335G>A	ENST00000319653.9	+	3	2127	c.1897G>A	c.(1897-1899)Gat>Aat	p.D633N	RP11-567G24.3_ENST00000444308.1_RNA|RP11-567G24.3_ENST00000412311.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	633					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.D776N(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAAACCTCCCGATGAGGAACA	0.483													6	51					0	0	1	0	0	A	240341335	G	A	240341335	3	1	48	1	0	0	0	0	1	0	0	0	5982	1058	37	1	1907	1	FMN2	1	240341335	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2369064	240341335	8909286	405	4799										
FMN2	56776	broad.mit.edu	37	chr1	240492401	240492401	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagtcagacgaactcgaaaAaatagaaaagcatggccgat	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:240492401A>C	ENST00000319653.9	+	9	4471	c.4241A>C	c.(4240-4242)aAa>aCa	p.K1414T	FMN2_ENST00000545751.1_Missense_Mutation_p.K10T	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1414	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAACTCGAAAAAATAGAAAAG	0.393													28	50					0	0	1	0	0	C	240492401	A	C	240492401	3	2	48	1	0	0	0	0	1	0	0	0	5982	14	1	4	4275	4	FMN2	1	240492401	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	151066	240492401	8758220	406	4800										
FMN2	56776	broad.mit.edu	37	chr1	240635744	240635744	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaataaaaccaagacatgaCtctggaattgtaagtattac	6	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:240635744C>T	ENST00000319653.9	+	17	5363	c.5133C>T	c.(5131-5133)gaC>gaT	p.D1711D	FMN2_ENST00000496950.1_3'UTR|FMN2_ENST00000543681.1_Silent_p.D31D|FMN2_ENST00000545751.1_Silent_p.D307D|AL646016.1_ENST00000596886.1_Intron	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1711					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAAGACATGACTCTGGAATTG	0.274													5	28					0	0	1	0	0	T	240635744	C	T	240635744	2	4	48	1	0	0	0	0	0	0	0	1	5982	564	20	3		3	FMN2	1	240635744	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	143343	240635744	8614877	407	4801										
RGS7	6000	broad.mit.edu	37	chr1	240966271	240966271	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacgtgggtatgaatcacttTtcatcagtttgtaaatgtgc	9	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:240966271T>G	ENST00000366565.1	-	16	1673	c.1292A>C	c.(1291-1293)aAa>aCa	p.K431T	RGS7_ENST00000366564.1_Missense_Mutation_p.K431T|RGS7_ENST00000348120.2_Missense_Mutation_p.K378T|RGS7_ENST00000401882.1_Missense_Mutation_p.K378T|RGS7_ENST00000407727.1_Missense_Mutation_p.K431T|RGS7_ENST00000446183.2_Missense_Mutation_p.K347T|RGS7_ENST00000366562.4_Missense_Mutation_p.K431T|RGS7_ENST00000331110.7_Missense_Mutation_p.K405T|RGS7_ENST00000366563.1_Missense_Mutation_p.K431T	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	431	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TGAATCACTTTTCATCAGTTT	0.358													25	44					0	0	1	0	0	G	240966271	T	G	240966271	3	3	48	1	0	0	0	0	1	0	0	0	13359	1841	64	4	183	4	RGS7	1	240966271	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	330527	240966271	8284350	408	4802										
PLD5	200150	broad.mit.edu	37	chr1	242264056	242264056	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgttcttttgtagcacaaGcattctctctttccagatca	5	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:242264056G>T	ENST00000442594.2	-	10	1501	c.992C>A	c.(991-993)gCt>gAt	p.A331D	PLD5_ENST00000427495.1_Missense_Mutation_p.A361D|PLD5_ENST00000536534.1_Missense_Mutation_p.A423D	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	423						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TGTAGCACAAGCATTCTCTCT	0.393													25	39					1.66031e-10	2.0393e-10	1	1	0	T	242264056	G	T	242264056	3	4	48	1	0	0	0	0	1	0	0	0	12096	971	34	5	350	5	PLD5	1	242264056	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1297785	242264056	6986565	409	4803										
KIF26B	55083	broad.mit.edu	37	chr1	245849741	245849741	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggttcccggaaactcctgtCgatgatgagcagcaggcagc	14	11	0	2	rs146698496	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:245849741C>T	ENST00000366518.4	+	9	2417	c.2313C>T	c.(2311-2313)gtC>gtT	p.V771V	KIF26B_ENST00000407071.2_Silent_p.V1152V			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1152					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAACTCCTGTCGATGATGAGC	0.587													34	70					0	0	1	0	0	T	245849741	C	T	245849741	2	4	48	1	0	0	0	0	0	0	0	1	8336	871	31	1		1	KIF26B	1	245849741	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3585685	245849741	3400880	410	4804										
OR2W5	0	broad.mit.edu	37	chr1	247654907	247654907	+	RNA	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctaaactccttcatcatgTgtcctcagacgatgcagctc	6	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:247654907T>C	ENST00000522351.1	+	0	538							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CTTCATCATGTGTCCTCAGAC	0.572													39	65					0	0	1	0	0	C	247654907	T	C	247654907	1	2	48	0	1	0	0	0	0	0	0	0	11081	1696	59	4		4	OR2W5	1	247654907	RNA	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1805166	247654907	1595714	411	4805										
OR2C3	81472	broad.mit.edu	37	chr1	247695252	247695252	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctggtatccacacaagccaGttgcataatgaggggcatct	11	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:247695252G>T	ENST00000366487.3	-	2	923	c.562C>A	c.(562-564)Ctg>Atg	p.L188M	GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000366490.3_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ACACAAGCCAGTTGCATAATG	0.547													15	28					2.31682e-05	2.54096e-05	1	1	0	T	247695252	G	T	247695252	3	4	48	1	0	0	0	0	1	0	0	0	11040	1020	36	5	404	5	OR2C3	1	247695252	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40345	247695252	1555369	412	4806										
OR6F1	343169	broad.mit.edu	37	chr1	247875278	247875278	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatctttgatagaggtgcgGacgtgaaggaaaactgtgga	15	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:247875278G>A	ENST00000302084.2	-	1	827	c.780C>T	c.(778-780)gtC>gtT	p.V260V	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TAGAGGTGCGGACGTGAAGGA	0.527													6	92					0	0	1	0	0	A	247875278	G	A	247875278	2	1	48	1	0	0	0	0	0	0	0	1	11247	1161	41	3		3	OR6F1	1	247875278	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	180026	247875278	1375343	413	4807										
OR6F1	343169	broad.mit.edu	37	chr1	247875344	247875344	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgcgaggagcacgtggaGaaggctttgctccggccact	15	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:247875344G>T	ENST00000302084.2	-	1	761	c.714C>A	c.(712-714)ttC>ttA	p.F238L	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGCACGTGGAGAAGGCTTTGC	0.522													18	120					8.34094e-07	9.42356e-07	1	1	0	T	247875344	G	T	247875344	3	4	48	1	0	0	0	0	1	0	0	0	11247	933	33	2	216	2	OR6F1	1	247875344	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	66	247875344	1375277	414	4808										
OR1C1	26188	broad.mit.edu	37	chr1	247921674	247921674	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggaagtcccagaaggacgAattccctgacaactgttaga	10	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:247921674A>G	ENST00000408896.2	-	1	308	c.35T>C	c.(34-36)tTc>tCc	p.F12S		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CAGAAGGACGAATTCCCTGAC	0.408													4	33					0	0	1	0	0	G	247921674	A	G	247921674	3	3	48	1	0	0	0	0	1	0	0	0	10999	246	9	4	911	4	OR1C1	1	247921674	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	46330	247921674	1328947	415	4809										
OR14A16	284532	broad.mit.edu	37	chr1	247978588	247978588	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagcaatcagacccccataCagccaagacacagtggctct	7	15	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:247978588C>T	ENST00000357627.1	-	1	443	c.444G>A	c.(442-444)ctG>ctA	p.L148L		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						GACCCCCATACAGCCAAGACA	0.502													43	95					0	0	1	0	0	T	247978588	C	T	247978588	2	4	48	1	0	0	0	0	0	0	0	1	10992	465	17	3		3	OR14A16	1	247978588	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	56914	247978588	1272033	416	4810										
OR2W3	343171	broad.mit.edu	37	chr1	248059536	248059536	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccttggtgtttatcctgctCtcttacagctacattgtgag	8	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248059536C>T	ENST00000537741.1	+	3	905	c.648C>T	c.(646-648)ctC>ctT	p.L216L	OR2W3_ENST00000360358.3_Silent_p.L216L			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TTATCCTGCTCTCTTACAGCT	0.582													6	168					0	0	1	0	0	T	248059536	C	T	248059536	2	4	48	1	0	0	0	0	0	0	0	1	11080	900	32	3		3	OR2W3	1	248059536	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80948	248059536	1191085	417	4811										
OR2W3	343171	broad.mit.edu	37	chr1	248059822	248059822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggggaagagagagctaGgaaaggagtaaaggcatctc	15	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248059822G>A	ENST00000537741.1	+	3	1191	c.934G>A	c.(934-936)Gga>Aga	p.G312R	OR2W3_ENST00000360358.3_Missense_Mutation_p.G312R			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGAGAGCTAGGAAAGGAGTA	0.542													9	25					0	0	1	0	0	A	248059822	G	A	248059822	3	1	48	1	0	0	0	0	1	0	0	0	11080	1001	35	3	936	3	OR2W3	1	248059822	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	286	248059822	1190799	418	4812										
OR2L8	391190	broad.mit.edu	37	chr1	248113023	248113023	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaatgctcaaccccatcatCtatagcctgaggaacaagga	7	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248113023C>A	ENST00000357191.3	+	1	864	c.864C>A	c.(862-864)atC>atA	p.I288I	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACCCCATCATCTATAGCCTGA	0.498													8	88					0.000274275	0.000292037	1	1	0	A	248113023	C	A	248113023	2	1	48	1	0	0	0	0	0	0	0	1	11056	903	32	2		2	OR2L8	1	248113023	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53201	248113023	1137598	419	4813										
OR2L13	284521	broad.mit.edu	37	chr1	248262683	248262683	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcagaaagttttcatggaGaaatggaatcacacttcaaa	8	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248262683G>T	ENST00000366478.2	+	3	343	c.6G>T	c.(4-6)gaG>gaT	p.E2D	OR2L13_ENST00000358120.2_Missense_Mutation_p.E2D	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TTTTCATGGAGAAATGGAATC	0.333													21	35					7.41877e-09	8.8016e-09	1	1	0	T	248262683	G	T	248262683	3	4	48	1	0	0	0	0	1	0	0	0	11053	933	33	2	8	2	OR2L13	1	248262683	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	149660	248262683	987938	420	4814										
OR2M2	391194	broad.mit.edu	37	chr1	248343661	248343661	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttatgaccgctatattgCtatttgccaccctctaagat	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248343661C>A	ENST00000359682.2	+	1	374	c.374C>A	c.(373-375)gCt>gAt	p.A125D		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CGCTATATTGCTATTTGCCAC	0.393													12	265					2.27111e-07	2.60515e-07	1	1	0	A	248343661	C	A	248343661	3	1	48	1	0	0	0	0	1	0	0	0	11057	797	28	5	376	5	OR2M2	1	248343661	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80978	248343661	906960	421	4815										
OR2M3	127062	broad.mit.edu	37	chr1	248366810	248366810	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtggacttatgactgccttTtcctggatcctgggctctac	10	11	1	1	rs150518305	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248366810T>C	ENST00000456743.1	+	1	479	c.441T>C	c.(439-441)ttT>ttC	p.F147F		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGACTGCCTTTTCCTGGATCC	0.453													7	217					0	0	1	0	0	C	248366810	T	C	248366810	2	2	48	1	0	0	0	0	0	0	0	1	11058	1838	64	4		4	OR2M3	1	248366810	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23149	248366810	883811	422	4816										
OR2M4	26245	broad.mit.edu	37	chr1	248402359	248402359	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggcattgatggaaaatatTtccatggttctcctcatcta	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248402359T>G	ENST00000306687.1	+	1	129	c.129T>G	c.(127-129)atT>atG	p.I43M		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGAAAATATTTCCATGGTTC	0.483													43	83					0	0	1	0	0	G	248402359	T	G	248402359	3	3	48	1	0	0	0	0	1	0	0	0	11059	1829	64	4	131	4	OR2M4	1	248402359	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	35549	248402359	848262	423	4817										
OR2T12	127064	broad.mit.edu	37	chr1	248458370	248458370	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagaagaagtgatcgatctCgtgtgcaccgcaatatggga	13	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248458370C>T	ENST00000317996.1	-	1	510	c.511G>A	c.(511-513)Gag>Aag	p.E171K		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E171K(1)		endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TGATCGATCTCGTGTGCACCG	0.562													33	80					0	0	1	0	0	T	248458370	C	T	248458370	3	4	48	1	0	0	0	0	1	0	0	0	11066	893	31	1	454	1	OR2T12	1	248458370	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	56011	248458370	792251	424	4818										
OR2T1	26696	broad.mit.edu	37	chr1	248569685	248569685	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttccactattgtgcctaaGatgctggttaattacctgct	7	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248569685G>T	ENST00000366474.1	+	1	390	c.390G>T	c.(388-390)aaG>aaT	p.K130N		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K130N(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGTGCCTAAGATGCTGGTTA	0.453													45	100					2.35958e-20	3.23214e-20	1	1	0	T	248569685	G	T	248569685	3	4	48	1	0	0	0	0	1	0	0	0	11063	933	33	2	392	2	OR2T1	1	248569685	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	111315	248569685	680936	425	4819										
OR2T5	401993	broad.mit.edu	37	chr1	248651994	248651994	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctctacttagtgtggtcatCtttgtggttttcctgaaggc	11	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr1:248651994C>A	ENST00000366473.2	+	1	110	c.105C>A	c.(103-105)atC>atA	p.I35I		NM_001004697.1	NP_001004697.1	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T, member 5	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(2)|pancreas(1)|skin(2)	9	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGTGGTCATCTTTGTGGTTT	0.488													23	90					2.05212e-20	2.81235e-20	1	1	0	A	248651994	C	A	248651994	2	1	48	1	0	0	0	0	0	0	0	1	11075	903	32	2		2	OR2T5	1	248651994	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	82309	248651994	598627	426	4820										
SH3YL1	26751	broad.mit.edu	37	chr2	218858	218858	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaatgccagtttgacctcGaagttttccttcccaccaat	5	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:218858G>A	ENST00000403657.1	-	12	2832	c.637C>T	c.(637-639)Cga>Tga	p.R213*	SH3YL1_ENST00000403712.2_Nonsense_Mutation_p.R309*|SH3YL1_ENST00000405430.1_Nonsense_Mutation_p.R328*|SH3YL1_ENST00000415006.2_Nonsense_Mutation_p.R232*|SH3YL1_ENST00000403658.1_Nonsense_Mutation_p.R213*|SH3YL1_ENST00000356150.5_Nonsense_Mutation_p.R328*|SH3YL1_ENST00000468321.1_5'UTR			Q96HL8	SH3Y1_HUMAN	SH3 and SYLF domain containing 1	328										large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	7	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		GTTTGACCTCGAAGTTTTCCT	0.358													18	26					0	0	1	0	0	A	218858	G	A	218858	4	1	48	1	0	0	0	0	0	1	0	0	14317	1066	37	1	50	1	SH3YL1	2	218858	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		218858	242980515	427	4821										
SNTG2	54221	broad.mit.edu	37	chr2	1263164	1263164	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcacattcgattgggtgcGagcagaaaggacctatcacc	12	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:1263164G>A	ENST00000308624.5	+	13	1157	c.1028G>A	c.(1027-1029)cGa>cAa	p.R343Q	SNTG2_ENST00000407292.1_Missense_Mutation_p.R216Q	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	343	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GATTGGGTGCGAGCAGAAAGG	0.388													15	35					0	0	1	0	0	A	1263164	G	A	1263164	3	1	48	1	0	0	0	0	1	0	0	0	14928	1058	37	1	1078	1	SNTG2	2	1263164	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1044306	1263164	241936209	428	4822										
MYT1L	23040	broad.mit.edu	37	chr2	1906946	1906946	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtcgtaactgttgtattcAaacgaggtcttggaatattt	9	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:1906946A>G	ENST00000399161.2	-	14	2685	c.1938T>C	c.(1936-1938)ttT>ttC	p.F646F	MYT1L_ENST00000428368.2_Silent_p.F644F	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	646					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGTTGTATTCAAACGAGGTCT	0.483													10	63					0	0	1	0	0	G	1906946	A	G	1906946	2	3	48	1	0	0	0	0	0	0	0	1	10154	127	5	4		4	MYT1L	2	1906946	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	643782	1906946	241292427	429	4823										
RPS7	6201	broad.mit.edu	37	chr2	3628443	3628443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctcacgggcaaggatgttAattttgaattcccagagttt	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:3628443A>G	ENST00000304921.5	+	7	720	c.556A>G	c.(556-558)Aat>Gat	p.N186D	RPS7_ENST00000406376.1_Missense_Mutation_p.N186D|RPS7_ENST00000403564.1_Missense_Mutation_p.N186D	NM_001011.3	NP_001002.1	P62081	RS7_HUMAN	ribosomal protein S7	186					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome			endometrium(1)|lung(2)|urinary_tract(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		CAAGGATGTTAATTTTGAATT	0.303													8	22					0	0	1	0	0	G	3628443	A	G	3628443	3	3	48	1	0	0	0	0	1	0	0	0	13711	362	13	4	578	4	RPS7	2	3628443	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1721497	3628443	239570930	430	4824										
ALLC	55821	broad.mit.edu	37	chr2	3727581	3727581	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaagcagcaaacttggaaGaaggtgcgttaggaaccact	11	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:3727581G>T	ENST00000252505.3	+	5	457	c.295G>T	c.(295-297)Gaa>Taa	p.E99*		NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	118							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		AAACTTGGAAGAAGGTGCGTT	0.547										HNSCC(21;0.051)			39	48					4.92203e-23	6.86763e-23	1	1	0	T	3727581	G	T	3727581	4	4	48	1	0	0	0	0	0	1	0	0	530	943	33	2	309	2	ALLC	2	3727581	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	99138	3727581	239471792	431	4825										
ALLC	55821	broad.mit.edu	37	chr2	3729237	3729237	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actacagataaactaccagaAatcccagaaagaggaaccag	7	10	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:3729237A>T	ENST00000252505.3	+	6	474	c.312A>T	c.(310-312)gaA>gaT	p.E104D		NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	123							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		AACTACCAGAAATCCCAGAAA	0.443										HNSCC(21;0.051)			12	16					0	0	1	0	0	T	3729237	A	T	3729237	3	4	48	1	0	0	0	0	1	0	0	0	530	11	1	4	330	4	ALLC	2	3729237	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1656	3729237	239470136	432	4826										
RSAD2	91543	broad.mit.edu	37	chr2	7030405	7030405	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgaagaatttgaaagattCttggagcgccacaaagaagt	11	5	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:7030405C>T	ENST00000382040.3	+	4	973	c.837C>T	c.(835-837)ttC>ttT	p.F279F	RSAD2_ENST00000541728.1_Silent_p.F172F	NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	279					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		TTGAAAGATTCTTGGAGCGCC	0.393													19	35					0	0	1	0	0	T	7030405	C	T	7030405	2	4	48	1	0	0	0	0	0	0	0	1	13746	912	32	3		3	RSAD2	2	7030405	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3301168	7030405	236168968	433	4827										
KIDINS220	57498	broad.mit.edu	37	chr2	8871069	8871069	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaattccctccatctcatcGaaattttgattggctctgtt	5	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:8871069G>A	ENST00000256707.3	-	30	5278	c.5097C>T	c.(5095-5097)ttC>ttT	p.F1699F	KIDINS220_ENST00000418530.1_Silent_p.F1600F|KIDINS220_ENST00000473731.1_Silent_p.F1680F|KIDINS220_ENST00000427284.1_Silent_p.F1680F	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1699					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCATCTCATCGAAATTTTGAT	0.468													25	31					0	0	1	0	0	A	8871069	G	A	8871069	2	1	48	1	0	0	0	0	0	0	0	1	8312	1049	37	1		1	KIDINS220	2	8871069	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1840664	8871069	234328304	434	4828										
ADAM17	6868	broad.mit.edu	37	chr2	9676860	9676860	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgaagaagtcctgccattTtacagtgtactcgctttcgt	9	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:9676860T>G	ENST00000310823.3	-	3	510	c.328A>C	c.(328-330)Aaa>Caa	p.K110Q	ADAM17_ENST00000497134.1_Missense_Mutation_p.K110Q	NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	110					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TCCTGCCATTTTACAGTGTAC	0.418													28	48					0	0	1	0	0	G	9676860	T	G	9676860	3	3	48	1	0	0	0	0	1	0	0	0	237	1850	64	4	2214	4	ADAM17	2	9676860	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	805791	9676860	233522513	435	4829										
TAF1B	9014	broad.mit.edu	37	chr2	10050892	10050892	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatagcttaacttgccacgTggtaaaaatgactggaatgg	11	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:10050892T>C	ENST00000263663.5	+	10	1171	c.983T>C	c.(982-984)gTg>gCg	p.V328A	TAF1B_ENST00000396242.3_Missense_Mutation_p.V73A	NM_005680.2	NP_005671.2	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	328					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ACTTGCCACGTGGTAAAAATG	0.343													4	53					0	0	1	0	0	C	10050892	T	C	10050892	3	2	48	1	0	0	0	0	1	0	0	0	15576	1696	59	4	1021	4	TAF1B	2	10050892	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	374032	10050892	233148481	436	4830										
GRHL1	29841	broad.mit.edu	37	chr2	10104055	10104055	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagaagcttcaaaatcacttCgacagaagccaggagacagt	9	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:10104055C>T	ENST00000324907.9	+	6	923	c.787C>T	c.(787-789)Cga>Tga	p.R263*	GRHL1_ENST00000324883.5_Nonsense_Mutation_p.R74*|GRHL1_ENST00000405379.2_Nonsense_Mutation_p.R263*	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	263					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		AAAATCACTTCGACAGAAGCC	0.438													11	31					0	0	1	0	0	T	10104055	C	T	10104055	4	4	48	1	0	0	0	0	0	1	0	0	6803	876	31	1	809	1	GRHL1	2	10104055	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53163	10104055	233095318	437	4831										
ODC1	4953	broad.mit.edu	37	chr2	10582167	10582167	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgtctgttcctttaatacaAttttcttggcaatgatatta	5	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:10582167A>C	ENST00000234111.4	-	9	1394	c.884T>G	c.(883-885)aTt>aGt	p.I295S	ODC1_ENST00000405333.1_Missense_Mutation_p.I295S	NM_002539.1	NP_002530.1	P11926	DCOR_HUMAN	ornithine decarboxylase 1	295					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			NS(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(3)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	CTTTAATACAATTTTCTTGGC	0.398													9	61					0	0	1	0	0	C	10582167	A	C	10582167	3	2	48	1	0	0	0	0	1	0	0	0	10872	101	4	4	517	4	ODC1	2	10582167	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	478112	10582167	232617206	438	4832										
NOL10	79954	broad.mit.edu	37	chr2	10712246	10712246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgacttcaggtgtccggccGaacgacggagtcttttcctt	11	11	2	1	rs142436125		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:10712246G>A	ENST00000345985.3	-	20	1978	c.1868C>T	c.(1867-1869)tCg>tTg	p.S623L	NOL10_ENST00000542668.1_Missense_Mutation_p.S623L|NOL10_ENST00000538384.1_Missense_Mutation_p.S647L|NOL10_ENST00000381685.5_Missense_Mutation_p.S673L	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	673						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		GTGTCCGGCCGAACGACGGAG	0.483													53	84					0	0	1	0	0	A	10712246	G	A	10712246	3	1	48	1	0	0	0	0	1	0	0	0	10566	1059	37	1	52	1	NOL10	2	10712246	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	130079	10712246	232487127	439	4833										
NOL10	79954	broad.mit.edu	37	chr2	10729370	10729370	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcatcatctgaactctccGaactttctgcatcacttggt	5	12	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:10729370G>A	ENST00000345985.3	-	18	1603	c.1493C>T	c.(1492-1494)tCg>tTg	p.S498L	NOL10_ENST00000542668.1_Missense_Mutation_p.S498L|AC092687.5_ENST00000414538.1_RNA|NOL10_ENST00000538384.1_Missense_Mutation_p.S522L|NOL10_ENST00000381685.5_Missense_Mutation_p.S548L	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	548						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TGAACTCTCCGAACTTTCTGC	0.493													18	44					0	0	1	0	0	A	10729370	G	A	10729370	3	1	48	1	0	0	0	0	1	0	0	0	10566	1059	37	1	435	1	NOL10	2	10729370	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17124	10729370	232470003	440	4834										
ROCK2	9475	broad.mit.edu	37	chr2	11337450	11337450	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcatctgcagttcaattcGaatctggctctcttcagcta	7	11	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:11337450G>A	ENST00000315872.6	-	27	3752	c.3304C>T	c.(3304-3306)Cga>Tga	p.R1102*	ROCK2_ENST00000401753.1_Nonsense_Mutation_p.R859*	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1102					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AGTTCAATTCGAATCTGGCTC	0.368													16	33					0	0	1	0	0	A	11337450	G	A	11337450	4	1	48	1	0	0	0	0	0	1	0	0	13569	1066	37	1	890	1	ROCK2	2	11337450	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	608080	11337450	231861923	441	4835										
ROCK2	9475	broad.mit.edu	37	chr2	11364495	11364495	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctttgcatgtttggaaatTtctgcatcttcagggaaaca	8	7	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:11364495T>G	ENST00000315872.6	-	7	1408	c.960A>C	c.(958-960)gaA>gaC	p.E320D	ROCK2_ENST00000401753.1_Missense_Mutation_p.E77D	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	320	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTTTGGAAATTTCTGCATCTT	0.323													29	36					0	0	1	0	0	G	11364495	T	G	11364495	3	3	48	1	0	0	0	0	1	0	0	0	13569	1838	64	4	3314	4	ROCK2	2	11364495	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	27045	11364495	231834878	442	4836										
NBAS	51594	broad.mit.edu	37	chr2	15555741	15555741	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctaaagttactaaatattCttttaatagctcattagcca	4	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:15555741C>A	ENST00000281513.5	-	25	2891	c.2866G>T	c.(2866-2868)Gaa>Taa	p.E956*	NBAS_ENST00000441750.1_Intron	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	956										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						ACTAAATATTCTTTTAATAGC	0.368													24	41					1.55469e-16	2.07108e-16	1	1	0	A	15555741	C	A	15555741	4	1	48	1	0	0	0	0	0	1	0	0	10233	922	32	2	4361	2	NBAS	2	15555741	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4191246	15555741	227643632	443	4837										
FAM49A	81553	broad.mit.edu	37	chr2	16740730	16740730	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcacaactattcttacatCgatcttggatgtcttgcaga	6	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:16740730C>T	ENST00000381323.3	-	10	1055	c.835G>A	c.(835-837)Gat>Aat	p.D279N	FAM49A_ENST00000406434.1_Missense_Mutation_p.D279N|FAM49A_ENST00000355549.2_Missense_Mutation_p.D279N	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	279						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			ATTCTTACATCGATCTTGGAT	0.483													39	45					0	0	1	0	0	T	16740730	C	T	16740730	3	4	48	1	0	0	0	0	1	0	0	0	5610	884	31	1	148	1	FAM49A	2	16740730	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1184989	16740730	226458643	444	4838										
RDH14	57665	broad.mit.edu	37	chr2	18736896	18736896	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtatttataaagtttggaaGaaactaccacaatcctgctg	7	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:18736896G>T	ENST00000381249.3	-	2	679	c.572C>A	c.(571-573)tCt>tAt	p.S191Y	NT5C1B-RDH14_ENST00000532967.1_3'UTR|RDH14_ENST00000468071.1_5'UTR	NM_020905.3	NP_065956.1			retinol dehydrogenase 14 (all-trans/9-cis/11-cis)											breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)					AAGTTTGGAAGAAACTACCAC	0.418													8	54					0.0381472	0.0387537	1	1	0	T	18736896	G	T	18736896	3	4	48	1	0	0	0	0	1	0	0	0	13244	942	33	2	442	2	RDH14	2	18736896	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1996166	18736896	224462477	445	4839										
NT5C1B	93034	broad.mit.edu	37	chr2	18764226	18764226	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataagtcctgttcatcaggaTatagatcacggagtctagca	9	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:18764226T>C	ENST00000304081.4	-	6	1029	c.929A>G	c.(928-930)tAt>tGt	p.Y310C	NT5C1B_ENST00000359846.2_Missense_Mutation_p.Y370C|NT5C1B_ENST00000600945.1_Missense_Mutation_p.Y370C|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.Y370C	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TTCATCAGGATATAGATCACG	0.463													9	35					0	0	1	0	0	C	18764226	T	C	18764226	3	2	48	1	0	0	0	0	1	0	0	0	10733	1406	49	4	739	4	NT5C1B	2	18764226	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	27330	18764226	224435147	446	4840										
MATN3	4148	broad.mit.edu	37	chr2	20200270	20200270	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaatgatgggaccctgttCtgtcattcacacaaatgtgc	8	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:20200270C>A	ENST00000407540.3	-	5	1162	c.1100G>T	c.(1099-1101)aGa>aTa	p.R367I	MATN3_ENST00000421259.2_Missense_Mutation_p.R325I|AC079145.4_ENST00000416575.1_RNA	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	367	EGF-like 3.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding	p.R367K(1)		central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGACCCTGTTCTGTCATTCAC	0.388													10	24					2.74318e-10	3.35981e-10	1	1	0	A	20200270	C	A	20200270	3	1	48	1	0	0	0	0	1	0	0	0	9384	913	32	2	376	2	MATN3	2	20200270	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1436044	20200270	222999103	447	4841										
APOB	338	broad.mit.edu	37	chr2	21225596	21225596	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaaccattatggactttcGaatatacctgggacagtacc	8	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:21225596G>A	ENST00000233242.1	-	29	12825	c.12698C>T	c.(12697-12699)tCg>tTg	p.S4233L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4233					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGGACTTTCGAATATACCTG	0.413													16	39					0	0	1	0	0	A	21225596	G	A	21225596	3	1	48	1	0	0	0	0	1	0	0	0	782	1059	37	1	997	1	APOB	2	21225596	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1025326	21225596	221973777	448	4842										
APOB	338	broad.mit.edu	37	chr2	21230633	21230633	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgggctgaaaagaaaagaGaatttttcaaagttccaata	9	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:21230633G>T	ENST00000233242.1	-	26	9234	c.9107C>A	c.(9106-9108)tCt>tAt	p.S3036Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3036					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.S3036Y(1)		NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAAGAAAAGAGAATTTTTCAA	0.408													14	32					0.00244969	0.00255607	1	1	0	T	21230633	G	T	21230633	3	4	48	1	0	0	0	0	1	0	0	0	782	942	33	2	4600	2	APOB	2	21230633	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5037	21230633	221968740	449	4843										
ATAD2B	54454	broad.mit.edu	37	chr2	23980445	23980445	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactggtcctccagaagaatCttttgttcagaactacattt	7	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:23980445C>A	ENST00000238789.5	-	25	4264	c.3921G>T	c.(3919-3921)aaG>aaT	p.K1307N	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1307							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGAAGAATCTTTTGTTCAG	0.383													8	129					0.00621372	0.0064192	1	1	0	A	23980445	C	A	23980445	3	1	48	1	0	0	0	0	1	0	0	0	1071	912	32	2	471	2	ATAD2B	2	23980445	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2749812	23980445	219218928	450	4844										
ATAD2B	54454	broad.mit.edu	37	chr2	23980888	23980889	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatttggtgtcttcttcatcINStttttttaaattattaactt							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:23980888_23980889insT	ENST00000238789.5	-	25	3820_3821	c.3477_3478insA	c.(3475-3480)aaatgafs	p.*1160fs	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1160							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTCTTCATCTTTTTTTAAAT	0.386													11	37	---	---	---	---						T	23980889	-	T	23980888	7	5	48	1	0	1	1	0	0	0	0	0	1071	913	32	0	914	0	ATAD2B	2	23980888	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	443	23980888	219218485	451	4845										
C2orf44	80304	broad.mit.edu	37	chr2	24261807	24261807	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtgaagagtcttctgagcGctgtcccaaatataagaatg	10	8	2	4	rs151169389	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:24261807G>A	ENST00000295148.4	-	2	615	c.558C>T	c.(556-558)agC>agT	p.S186S	C2orf44_ENST00000406895.3_Silent_p.S186S	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	186							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTCTGAGCGCTGTCCCAAA	0.557			T	ALK	NSCLC								10	37					0	0	1	0	0	A	24261807	G	A	24261807	2	1	48	1	0	0	0	0	0	0	0	1	2182	1078	38	1		1	C2orf44	2	24261807	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	280919	24261807	218937566	452	4846										
ITSN2	50618	broad.mit.edu	37	chr2	24509172	24509172	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttctttaagtctttggcatAattcttccttttctaatgat	5	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:24509172A>C	ENST00000355123.4	-	16	2215	c.1772T>G	c.(1771-1773)tTa>tGa	p.L591*	ITSN2_ENST00000361999.3_Nonsense_Mutation_p.L591*|ITSN2_ENST00000406921.3_Nonsense_Mutation_p.L591*	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	591					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTTGGCATAATTCTTCCTT	0.308													4	33					0	0	1	0	0	C	24509172	A	C	24509172	4	2	48	1	0	0	0	0	0	1	0	0	7970	372	13	4	3472	4	ITSN2	2	24509172	Nonsense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	247365	24509172	218690201	453	4847										
DNAJC27	51277	broad.mit.edu	37	chr2	25194715	25194715	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcggcgttgcccatggagAtgactttgatgcggagagac	14	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:25194715A>G	ENST00000264711.2	-	1	248	c.59T>C	c.(58-60)aTc>aCc	p.I20T	DNAJC27-AS1_ENST00000451291.1_RNA|DNAJC27-AS1_ENST00000421904.1_RNA	NM_001198559.1|NM_016544.2	NP_001185488.1|NP_057628.1	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	20					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						GCCCATGGAGATGACTTTGAT	0.677													11	17					0	0	1	0	0	G	25194715	A	G	25194715	3	3	48	1	0	0	0	0	1	0	0	0	4672	333	12	4	790	4	DNAJC27	2	25194715	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	685543	25194715	218004658	454	4848										
POMC	5443	broad.mit.edu	37	chr2	25387575	25387575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcaccagccacgcacttCcatggaggcctgaagcagca	11	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:25387575C>T	ENST00000405623.1	-	2	522	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	POMC_ENST00000264708.3_Missense_Mutation_p.E23K|POMC_ENST00000395826.2_Missense_Mutation_p.E23K|POMC_ENST00000380794.1_Missense_Mutation_p.E23K			P01189	COLI_HUMAN	proopiomelanocortin	23					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	CCACGCACTTCCATGGAGGCC	0.617													31	65					0	0	1	0	0	T	25387575	C	T	25387575	3	4	48	1	0	0	0	0	1	0	0	0	12289	864	30	3	744	3	POMC	2	25387575	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	192860	25387575	217811798	455	4849										
ASXL2	55252	broad.mit.edu	37	chr2	25966456	25966456	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagctgctggcaaagtgctcGagggtggagctgatccagca	15	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:25966456G>A	ENST00000435504.4	-	13	3043	c.2750C>T	c.(2749-2751)tCg>tTg	p.S917L	ASXL2_ENST00000336112.4_Missense_Mutation_p.S889L|ASXL2_ENST00000272341.4_Intron|ASXL2_ENST00000404843.1_Intron			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	917					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAAAGTGCTCGAGGGTGGAGC	0.473													51	101					0	0	1	0	0	A	25966456	G	A	25966456	3	1	48	1	0	0	0	0	1	0	0	0	1066	1059	37	1	1561	1	ASXL2	2	25966456	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	578881	25966456	217232917	456	4850										
ASXL2	55252	broad.mit.edu	37	chr2	26022301	26022301	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctccttgttgctgccaccaTcactgctgctgctgctgttc	8	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:26022301T>C	ENST00000435504.4	-	5	649	c.356A>G	c.(355-357)gAt>gGt	p.D119G	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000336112.4_Missense_Mutation_p.D91G|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	119	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGCCACCATCACTGCTGCT	0.478													13	90					0	0	1	0	0	C	26022301	T	C	26022301	3	2	48	1	0	0	0	0	1	0	0	0	1066	1435	50	4	3987	4	ASXL2	2	26022301	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	55845	26022301	217177072	457	4851										
KHK	3795	broad.mit.edu	37	chr2	27315234	27315234	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatggcagcgcggaggcaacGcgtccaactcctgcaccgtt	13	14	0	0	rs104893644		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27315234G>A	ENST00000260599.6	+	2	640	c.127G>A	c.(127-129)Gcg>Acg	p.A43T	KHK_ENST00000260598.5_Missense_Mutation_p.A43T|KHK_ENST00000490823.1_3'UTR	NM_000221.2	NP_000212.1	P50053	KHK_HUMAN	ketohexokinase (fructokinase)	43			A -> T (in FRUCT).		fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGGAGGCAACGCGTCCAACTC	0.612													25	37					0	0	1	0	0	A	27315234	G	A	27315234	3	1	48	1	0	0	0	0	1	0	0	0	8190	1087	38	1	133	1	KHK	2	27315234	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1292933	27315234	215884139	458	4852										
CGREF1	10669	broad.mit.edu	37	chr2	27324190	27324190	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtgcacctcaaagtcattTtgggtgttcttagactccag	9	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27324190T>C	ENST00000402394.1	-	6	1177	c.909A>G	c.(907-909)caA>caG	p.Q303Q	CGREF1_ENST00000260595.5_Silent_p.Q286Q|CGREF1_ENST00000405600.1_Silent_p.Q303Q|CGREF1_ENST00000404694.3_Silent_p.Q425Q|CGREF1_ENST00000312734.4_Silent_p.Q303Q|CGREF1_ENST00000402550.1_Intron|CGREF1_ENST00000452318.2_Intron	NM_006569.5	NP_006560.3	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	286					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAAAGTCATTTTGGGTGTTCT	0.532													69	139					0	0	1	0	0	C	27324190	T	C	27324190	2	2	48	1	0	0	0	0	0	0	0	1	3327	1838	64	4		4	CGREF1	2	27324190	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8956	27324190	215875183	459	4853										
SLC5A6	8884	broad.mit.edu	37	chr2	27430447	27430447	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accacatagtccatgatggaGaaggtagacatgcccacgct	10	11	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27430447G>T	ENST00000310574.3	-	3	545	c.72C>A	c.(70-72)ttC>ttA	p.F24L	SLC5A6_ENST00000408041.1_Missense_Mutation_p.F24L	NM_021095.2	NP_066918.2	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	24					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(3)|prostate(1)|skin(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	CCATGATGGAGAAGGTAGACA	0.567													20	48					3.51602e-12	4.42195e-12	1	1	0	T	27430447	G	T	27430447	3	4	48	1	0	0	0	0	1	0	0	0	14723	933	33	2	1895	2	SLC5A6	2	27430447	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	106257	27430447	215768926	460	4854										
GTF3C2	2976	broad.mit.edu	37	chr2	27551727	27551727	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacccaaacggtgccttttCgaggagcagtgaagtaggcc	12	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27551727C>T	ENST00000359541.2	-	15	2540	c.2111G>A	c.(2110-2112)cGa>cAa	p.R704Q	GTF3C2_ENST00000264720.3_Missense_Mutation_p.R704Q			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	704						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGCCTTTTCGAGGAGCAGT	0.403													13	26					0	0	1	0	0	T	27551727	C	T	27551727	3	4	48	1	0	0	0	0	1	0	0	0	6913	884	31	1	644	1	GTF3C2	2	27551727	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	121280	27551727	215647646	461	4855										
GTF3C2	2976	broad.mit.edu	37	chr2	27565787	27565787	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agattctggccgatctaggtCttttgacaacttcagcagca	9	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27565787C>A	ENST00000359541.2	-	3	904	c.475G>T	c.(475-477)Gac>Tac	p.D159Y	GTF3C2_ENST00000264720.3_Missense_Mutation_p.D159Y			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	159						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGATCTAGGTCTTTTGACAAC	0.552													33	51					1.99505e-19	2.71627e-19	1	1	0	A	27565787	C	A	27565787	3	1	48	1	0	0	0	0	1	0	0	0	6913	913	32	2	2328	2	GTF3C2	2	27565787	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	14060	27565787	215633586	462	4856										
IFT172	26160	broad.mit.edu	37	chr2	27700448	27700448	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcattttcaaagaaatacTtctcattgccaccagatcct	3	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27700448T>G	ENST00000260570.3	-	12	1302	c.1199A>C	c.(1198-1200)aAg>aCg	p.K400T	IFT172_ENST00000359466.6_Missense_Mutation_p.K400T|IFT172_ENST00000416524.2_Missense_Mutation_p.K379T	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	400					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					AAAGAAATACTTCTCATTGCC	0.403													16	30					0	0	1	0	0	G	27700448	T	G	27700448	3	3	48	1	0	0	0	0	1	0	0	0	7600	1609	56	4	4198	4	IFT172	2	27700448	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	134661	27700448	215498925	463	4857										
IFT172	26160	broad.mit.edu	37	chr2	27708255	27708255	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctggtttggtggagaatTtatctctccgttctccatgt	10	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27708255T>G	ENST00000260570.3	-	2	258	c.155A>C	c.(154-156)aAa>aCa	p.K52T	IFT172_ENST00000359466.6_Missense_Mutation_p.K52T|IFT172_ENST00000416524.2_Missense_Mutation_p.K31T	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	52					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GGTGGAGAATTTATCTCTCCG	0.453													49	66					0	0	1	0	0	G	27708255	T	G	27708255	3	3	48	1	0	0	0	0	1	0	0	0	7600	1841	64	4	5282	4	IFT172	2	27708255	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7807	27708255	215491118	464	4858										
FNDC4	64838	broad.mit.edu	37	chr2	27716803	27716803	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacagatcctcacctgggcTtgaactgtttgaaggtagcc	11	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27716803T>G	ENST00000264703.3	-	4	839	c.448A>C	c.(448-450)Agc>Cgc	p.S150R		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	150						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					TCACCTGGGCTTGAACTGTTT	0.562													23	54					0	0	1	0	0	G	27716803	T	G	27716803	3	3	48	1	0	0	0	0	1	0	0	0	6003	1609	56	4	272	4	FNDC4	2	27716803	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8548	27716803	215482570	465	4859										
GCKR	2646	broad.mit.edu	37	chr2	27728635	27728635	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaggtggaagtgccaccaaGattctgctggaaaccctgtt	11	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:27728635G>T	ENST00000264717.2	+	10	864	c.801G>T	c.(799-801)aaG>aaT	p.K267N	GCKR_ENST00000424318.2_Missense_Mutation_p.K77N	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	267	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					GTGCCACCAAGATTCTGCTGG	0.542													34	67					9.78485e-24	1.37003e-23	1	1	0	T	27728635	G	T	27728635	3	4	48	1	0	0	0	0	1	0	0	0	6333	933	33	2	839	2	GCKR	2	27728635	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11832	27728635	215470738	466	4860										
FOSL2	2355	broad.mit.edu	37	chr2	28626994	28626994	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattccgggtagatatgccTggctcaggcagtgcattcat	11	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:28626994T>C	ENST00000264716.4	+	2	986	c.123T>C	c.(121-123)ccT>ccC	p.P41P	FOSL2_ENST00000460736.1_3'UTR|FOSL2_ENST00000545753.1_Silent_p.P2P|FOSL2_ENST00000379619.1_Silent_p.P16P	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	41					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					TAGATATGCCTGGCTCAGGCA	0.463													9	103					0	0	1	0	0	C	28626994	T	C	28626994	2	2	48	1	0	0	0	0	0	0	0	1	6020	1567	55	4		4	FOSL2	2	28626994	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	898359	28626994	214572379	467	4861										
PPP1CB	5500	broad.mit.edu	37	chr2	29001835	29001835	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tataaaatcaaatatccagaGaacttctttctcttaagagg	5	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:29001835G>T	ENST00000395366.2	+	3	617	c.345G>T	c.(343-345)gaG>gaT	p.E115D	PPP1CB_ENST00000296122.6_Missense_Mutation_p.E115D|PPP1CB_ENST00000358506.2_Missense_Mutation_p.E115D	NM_002709.2	NP_002700.1	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta isozyme	115					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					AATATCCAGAGAACTTCTTTC	0.343													14	30					4.3838e-07	4.998e-07	1	1	0	T	29001835	G	T	29001835	3	4	48	1	0	0	0	0	1	0	0	0	12398	933	33	2	355	2	PPP1CB	2	29001835	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	374841	29001835	214197538	468	4862										
C2orf71	388939	broad.mit.edu	37	chr2	29294728	29294728	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggggaaagataggtgctaaGggcttccagcctatgcccat	14	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:29294728G>T	ENST00000331664.5	-	1	2399	c.2400C>A	c.(2398-2400)ccC>ccA	p.P800P		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	800					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TAGGTGCTAAGGGCTTCCAGC	0.542													37	71					4.65686e-17	6.22576e-17	1	1	0	T	29294728	G	T	29294728	2	4	48	1	0	0	0	0	0	0	0	1	2205	987	35	5		5	C2orf71	2	29294728	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	292893	29294728	213904645	469	4863										
CAPN13	92291	broad.mit.edu	37	chr2	30957322	30957322	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtccccattgtacctgtattCtctatggccttccacaagtc	6	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:30957322C>A	ENST00000295055.8	-	19	1967	c.1791G>T	c.(1789-1791)gaG>gaT	p.E597D	CAPN13_ENST00000534090.2_Missense_Mutation_p.E597D	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	597					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TACCTGTATTCTCTATGGCCT	0.552													12	19					3.07112e-06	3.42433e-06	1	1	0	A	30957322	C	A	30957322	3	1	48	1	0	0	0	0	1	0	0	0	2644	912	32	2	234	2	CAPN13	2	30957322	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1662594	30957322	212242051	470	4864										
NLRC4	58484	broad.mit.edu	37	chr2	32449775	32449775	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatccatcactgctcacacGatttcccgccaaattcaact	3	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:32449775G>A	ENST00000404025.2	-	10	3330	c.2842C>T	c.(2842-2844)Cgt>Tgt	p.R948C	NLRC4_ENST00000360906.5_Missense_Mutation_p.R948C|NLRC4_ENST00000402280.1_Missense_Mutation_p.R948C|NLRC4_ENST00000342905.6_Missense_Mutation_p.R283C			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	948					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTGCTCACACGATTTCCCGCC	0.363													19	42					0	0	1	0	0	A	32449775	G	A	32449775	3	1	48	1	0	0	0	0	1	0	0	0	10515	1058	37	1	236	1	NLRC4	2	32449775	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1492453	32449775	210749598	471	4865										
NLRC4	58484	broad.mit.edu	37	chr2	32475335	32475335	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttttcacactttgcaaaGattcctgtctccagagaggc	8	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:32475335G>T	ENST00000404025.2	-	5	2086	c.1598C>A	c.(1597-1599)tCt>tAt	p.S533Y	NLRC4_ENST00000360906.5_Missense_Mutation_p.S533Y|NLRC4_ENST00000402280.1_Missense_Mutation_p.S533Y|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	533					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ACTTTGCAAAGATTCCTGTCT	0.463													26	44					8.24728e-16	1.09065e-15	1	1	0	T	32475335	G	T	32475335	3	4	48	1	0	0	0	0	1	0	0	0	10515	942	33	2	1500	2	NLRC4	2	32475335	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25560	32475335	210724038	472	4866										
NLRC4	58484	broad.mit.edu	37	chr2	32476392	32476392	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccccagagcatggcaattcGctgcagcagagtggacttgc	13	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:32476392G>A	ENST00000404025.2	-	5	1029	c.541C>T	c.(541-543)Cga>Tga	p.R181*	NLRC4_ENST00000360906.5_Nonsense_Mutation_p.R181*|NLRC4_ENST00000402280.1_Nonsense_Mutation_p.R181*|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	181	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ATGGCAATTCGCTGCAGCAGA	0.572													25	51					0	0	1	0	0	A	32476392	G	A	32476392	4	1	48	1	0	0	0	0	0	1	0	0	10515	1095	38	1	2557	1	NLRC4	2	32476392	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1057	32476392	210722981	473	4867										
BIRC6	57448	broad.mit.edu	37	chr2	32640478	32640478	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccggattctgagaagtggAactctgtgtttcccaagcct	10	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:32640478A>G	ENST00000421745.2	+	10	2253	c.2119A>G	c.(2119-2121)Aac>Gac	p.N707D		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	707					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TGAGAAGTGGAACTCTGTGTT	0.473													16	21					0	0	1	0	0	G	32640478	A	G	32640478	3	3	48	1	0	0	0	0	1	0	0	0	1437	246	9	4	2157	4	BIRC6	2	32640478	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	164086	32640478	210558895	474	4868										
LTBP1	4052	broad.mit.edu	37	chr2	33413754	33413754	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacaggccagaagacaaaaGaagctcaaccaggccaatcc	8	13	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:33413754G>T	ENST00000404816.2	+	7	1890	c.1537G>T	c.(1537-1539)Gaa>Taa	p.E513*	LTBP1_ENST00000404525.1_Nonsense_Mutation_p.E187*|LTBP1_ENST00000402934.1_Nonsense_Mutation_p.E187*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.E187*|LTBP1_ENST00000354476.3_Nonsense_Mutation_p.E513*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.E187*|LTBP1_ENST00000418533.2_Nonsense_Mutation_p.E187*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	513					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GAAGACAAAAGAAGCTCAACC	0.483													37	60					1.26612e-14	1.65413e-14	1	1	0	T	33413754	G	T	33413754	4	4	48	1	0	0	0	0	0	1	0	0	9117	943	33	2	1618	2	LTBP1	2	33413754	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	773276	33413754	209785619	475	4869										
CRIM1	51232	broad.mit.edu	37	chr2	36744477	36744477	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcatttcccagatgacttTgtggtgcagaagccagagct	11	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:36744477T>A	ENST00000280527.2	+	12	2365	c.1998T>A	c.(1996-1998)ttT>ttA	p.F666L		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	666					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CAGATGACTTTGTGGTGCAGA	0.458													26	37					0	0	1	0	0	A	36744477	T	A	36744477	3	1	48	1	0	0	0	0	1	0	0	0	3896	1809	63	4	2044	4	CRIM1	2	36744477	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3330723	36744477	206454896	476	4870										
STRN	6801	broad.mit.edu	37	chr2	37121137	37121137	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagagcttcttttgtatctcGatcttcaccgctgtcaggca	8	11	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37121137G>A	ENST00000263918.4	-	7	843	c.835C>T	c.(835-837)Cga>Tga	p.R279*	STRN_ENST00000379213.2_Nonsense_Mutation_p.R267*	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	279					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TTTGTATCTCGATCTTCACCG	0.383													8	61					0	0	1	0	0	A	37121137	G	A	37121137	4	1	48	1	0	0	0	0	0	1	0	0	15384	1066	37	1	1555	1	STRN	2	37121137	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	376660	37121137	206078236	477	4871										
HEATR5B	54497	broad.mit.edu	37	chr2	37235920	37235920	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacagtcgtcatcatcatcGtcagtatttttaattgctct	5	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37235920G>A	ENST00000233099.5	-	28	4451	c.4356C>T	c.(4354-4356)gaC>gaT	p.D1452D	HEATR5B_ENST00000354531.2_Silent_p.D1452D	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1452							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				CATCATCATCGTCAGTATTTT	0.378													55	88					0	0	1	0	0	A	37235920	G	A	37235920	2	1	48	1	0	0	0	0	0	0	0	1	7072	1136	40	1		1	HEATR5B	2	37235920	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	114783	37235920	205963453	478	4872										
HEATR5B	54497	broad.mit.edu	37	chr2	37268371	37268371	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcctattccaccaacataacGatgcaaacaaccaagagcca	5	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37268371G>A	ENST00000233099.5	-	19	2856	c.2761C>T	c.(2761-2763)Cgt>Tgt	p.R921C	HEATR5B_ENST00000354531.2_Missense_Mutation_p.R921C	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	921							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				CCAACATAACGATGCAAACAA	0.433													32	43					0	0	1	0	0	A	37268371	G	A	37268371	3	1	48	1	0	0	0	0	1	0	0	0	7072	1058	37	1	3526	1	HEATR5B	2	37268371	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	32451	37268371	205931002	479	4873										
HEATR5B	54497	broad.mit.edu	37	chr2	37287862	37287862	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcttgggcagatggtaacGaacgacagatggtcctagcc	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37287862G>A	ENST00000233099.5	-	12	1806	c.1711C>T	c.(1711-1713)Cgt>Tgt	p.R571C	HEATR5B_ENST00000354531.2_Missense_Mutation_p.R571C	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	571							binding	p.R571C(1)		breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				AGATGGTAACGAACGACAGAT	0.418													31	38					0	0	1	0	0	A	37287862	G	A	37287862	3	1	48	1	0	0	0	0	1	0	0	0	7072	1058	37	1	4604	1	HEATR5B	2	37287862	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19491	37287862	205911511	480	4874										
EIF2AK2	5610	broad.mit.edu	37	chr2	37374085	37374085	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accttcaccttctggaaattCtcttccatctattataactt	2	12	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37374085C>A	ENST00000233057.4	-	4	473	c.151G>T	c.(151-153)Gaa>Taa	p.E51*	EIF2AK2_ENST00000395127.2_Nonsense_Mutation_p.E51*|EIF2AK2_ENST00000405334.1_Nonsense_Mutation_p.E51*	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	51	DRBM 1.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				TCTGGAAATTCTCTTCCATCT	0.323													6	18					0.217242	0.218251	1	1	0	A	37374085	C	A	37374085	4	1	48	1	0	0	0	0	0	1	0	0	5023	922	32	2	1560	2	EIF2AK2	2	37374085	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	86223	37374085	205825288	481	4875										
CEBPZ	10153	broad.mit.edu	37	chr2	37455758	37455758	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgaggctggggtttcaaaGaatattcattgctgtactcc	10	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37455758G>T	ENST00000234170.5	-	2	723	c.578C>A	c.(577-579)tCt>tAt	p.S193Y		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	193					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.S193Y(1)		breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				GGGTTTCAAAGAATATTCATT	0.368													28	60					1.88708e-17	2.5355e-17	1	1	0	T	37455758	G	T	37455758	3	4	48	1	0	0	0	0	1	0	0	0	3226	942	33	2	2646	2	CEBPZ	2	37455758	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	81673	37455758	205743615	482	4876										
PRKD3	23683	broad.mit.edu	37	chr2	37487503	37487503	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaaacatacattccaggtTtacaatcccaggatggtgca	7	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37487503T>G	ENST00000379066.1	-	15	2671	c.1909A>C	c.(1909-1911)Aac>Cac	p.N637H	PRKD3_ENST00000234179.2_Missense_Mutation_p.N637H			O94806	KPCD3_HUMAN	protein kinase D3	637	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				CATTCCAGGTTTACAATCCCA	0.383													12	13					0	0	1	0	0	G	37487503	T	G	37487503	3	3	48	1	0	0	0	0	1	0	0	0	12571	1841	64	4	783	4	PRKD3	2	37487503	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	31745	37487503	205711870	483	4877										
QPCT	25797	broad.mit.edu	37	chr2	37586751	37586751	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagcgaattcagaggcttcAggctgactgggtcttggaaa	14	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:37586751A>C	ENST00000338415.3	+	3	454	c.296A>C	c.(295-297)cAg>cCg	p.Q99P	QPCT_ENST00000537448.1_Missense_Mutation_p.Q50P	NM_012413.3	NP_036545.1	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase	99					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|stomach(2)	17		Ovarian(717;0.051)|all_hematologic(82;0.21)				CAGAGGCTTCAGGCTGACTGG	0.398													19	29					0	0	1	0	0	C	37586751	A	C	37586751	3	2	48	1	0	0	0	0	1	0	0	0	12925	188	7	4	306	4	QPCT	2	37586751	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	99248	37586751	205612622	484	4878										
DHX57	90957	broad.mit.edu	37	chr2	39055483	39055483	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagaaagcaattagcttaccGattactacgtctgttgttga	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:39055483G>A	ENST00000295373.6	-	14	2764	c.2639_splice	c.e14+1	p.R880_splice		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	880	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TTAGCTTACCGATTACTACGT	0.388													10	23					0	0	1	0	0	A	39055483	G	A	39055483	5	1	48	1	0	0	0	0	0	0	1	0	4541	1072	37	1	1566	1	DHX57	2	39055483	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1468732	39055483	204143890	485	4879										
DHX57	90957	broad.mit.edu	37	chr2	39095357	39095357	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgattcactgaagatacaaAagtcatctccatcatcccat	4	11	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:39095357A>C	ENST00000295373.6	-	2	317	c.191T>G	c.(190-192)tTt>tGt	p.F64C		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	64							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				GAAGATACAAAAGTCATCTCC	0.468													24	72					0	0	1	0	0	C	39095357	A	C	39095357	3	2	48	1	0	0	0	0	1	0	0	0	4541	14	1	4	4061	4	DHX57	2	39095357	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	39874	39095357	204104016	486	4880										
MAP4K3	8491	broad.mit.edu	37	chr2	39499439	39499439	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttaccttggcagtattctgTcagggagtttgtgtgctgga	13	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:39499439T>C	ENST00000263881.3	-	26	2282	c.1958A>G	c.(1957-1959)gAc>gGc	p.D653G	MAP4K3_ENST00000437545.1_Missense_Mutation_p.D569G|MAP4K3_ENST00000536018.1_Missense_Mutation_p.D206G|MAP4K3_ENST00000341681.5_Missense_Mutation_p.D632G	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	653	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				CAGTATTCTGTCAGGGAGTTT	0.368													8	36					0	0	1	0	0	C	39499439	T	C	39499439	3	2	48	1	0	0	0	0	1	0	0	0	9310	1667	58	4	762	4	MAP4K3	2	39499439	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	404082	39499439	203699934	487	4881										
SLC8A1	6546	broad.mit.edu	37	chr2	40366764	40366764	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaagtgcatcacgtaatcGaaacaggagggcagcttctc	11	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:40366764G>A	ENST00000406785.1	-	7	2403	c.2214C>T	c.(2212-2214)ttC>ttT	p.F738F	SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1_ENST00000408028.2_Silent_p.F766F|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000405901.3_Silent_p.F769F|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000405269.1_Silent_p.F738F|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1_ENST00000403092.1_Silent_p.F774F|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1_ENST00000402441.1_Silent_p.F738F|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1_ENST00000406391.2_Silent_p.F738F|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1_ENST00000332839.4_Silent_p.F774F|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Silent_p.F769F|SLC8A1_ENST00000542024.1_Silent_p.F738F			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	774					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCACGTAATCGAAACAGGAGG	0.502													46	86					0	0	1	0	0	A	40366764	G	A	40366764	2	1	48	1	0	0	0	0	0	0	0	1	14760	1049	37	1		1	SLC8A1	2	40366764	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	867325	40366764	202832609	488	4882										
SLC8A1	6546	broad.mit.edu	37	chr2	40401859	40401859	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcttaccaaacaggtatttTccttcattaaaagcaaataa	4	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:40401859T>C	ENST00000403092.1	-	6	1989	c.1954_splice	c.e6-1	p.G652_splice	SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1_ENST00000408028.2_Splice_Site_p.G644_splice|SLC8A1_ENST00000406785.1_Intron|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000405901.3_Intron|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000405269.1_Intron|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1_ENST00000402441.1_Intron|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1_ENST00000406391.2_Intron|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1_ENST00000332839.4_Splice_Site_p.G652_splice|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Intron|SLC8A1_ENST00000542024.1_Intron			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	652					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACAGGTATTTTCCTTCATTAA	0.274													7	22					0	0	1	0	0	C	40401859	T	C	40401859	5	2	48	1	0	0	0	0	0	0	1	0	14760	1797	62	4	989	4	SLC8A1	2	40401859	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	35095	40401859	202797514	489	4883										
SLC8A1	6546	broad.mit.edu	37	chr2	40655715	40655715	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttatatggaacgataacaTttcctcgagctccagatgtt	7	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:40655715T>C	ENST00000406785.1	-	2	1895	c.1706A>G	c.(1705-1707)aAt>aGt	p.N569S	SLC8A1_ENST00000408028.2_Missense_Mutation_p.N569S|SLC8A1_ENST00000405901.3_Missense_Mutation_p.N569S|SLC8A1_ENST00000405269.1_Missense_Mutation_p.N569S|SLC8A1_ENST00000403092.1_Missense_Mutation_p.N569S|SLC8A1_ENST00000402441.1_Missense_Mutation_p.N569S|SLC8A1_ENST00000406391.2_Missense_Mutation_p.N569S|SLC8A1_ENST00000332839.4_Missense_Mutation_p.N569S|SLC8A1_ENST00000542756.1_Missense_Mutation_p.N569S|SLC8A1_ENST00000542024.1_Missense_Mutation_p.N569S			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	569	Calx-beta 2.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AACGATAACATTTCCTCGAGC	0.453													20	63					0	0	1	0	0	C	40655715	T	C	40655715	3	2	48	1	0	0	0	0	1	0	0	0	14760	1493	52	4	1363	4	SLC8A1	2	40655715	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	253856	40655715	202543658	490	4884										
THADA	63892	broad.mit.edu	37	chr2	43797628	43797628	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttataaagtacctgagaacTttcctgtatcctacaaaaca	4	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:43797628T>G	ENST00000403856.1	-	15	2233	c.2086A>C	c.(2086-2088)Agt>Cgt	p.S696R	THADA_ENST00000405006.4_Missense_Mutation_p.S696R|THADA_ENST00000330266.7_Missense_Mutation_p.S406R|THADA_ENST00000415080.2_Missense_Mutation_p.S406R|THADA_ENST00000405975.2_Missense_Mutation_p.S696R|THADA_ENST00000404790.1_Missense_Mutation_p.S696R|THADA_ENST00000402360.2_Missense_Mutation_p.S696R			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	696							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ACCTGAGAACTTTCCTGTATC	0.363													10	23					0	0	1	0	0	G	43797628	T	G	43797628	3	3	48	1	0	0	0	0	1	0	0	0	15899	1609	56	4	3875	4	THADA	2	43797628	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3141913	43797628	199401745	491	4885										
THADA	63892	broad.mit.edu	37	chr2	43798951	43798951	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttcttccatggaaacaatTtctgtgctccgattactttc	5	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:43798951T>G	ENST00000403856.1	-	14	2106	c.1959A>C	c.(1957-1959)gaA>gaC	p.E653D	THADA_ENST00000405006.4_Missense_Mutation_p.E653D|THADA_ENST00000330266.7_Missense_Mutation_p.E363D|THADA_ENST00000415080.2_Missense_Mutation_p.E363D|THADA_ENST00000405975.2_Missense_Mutation_p.E653D|THADA_ENST00000404790.1_Missense_Mutation_p.E653D|THADA_ENST00000402360.2_Missense_Mutation_p.E653D			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	653							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TGGAAACAATTTCTGTGCTCC	0.358													39	60					0	0	1	0	0	G	43798951	T	G	43798951	3	3	48	1	0	0	0	0	1	0	0	0	15899	1838	64	4	4006	4	THADA	2	43798951	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1323	43798951	199400422	492	4886										
DYNC2LI1	51626	broad.mit.edu	37	chr2	44021614	44021614	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggacgttttctcttgttctCgttctggatctttcaaaacc	7	10	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:44021614C>T	ENST00000260605.8	+	6	439	c.339C>T	c.(337-339)ctC>ctT	p.L113L	DYNC2LI1_ENST00000489222.2_3'UTR|DYNC2LI1_ENST00000398823.2_3'UTR|DYNC2LI1_ENST00000443170.3_5'UTR|DYNC2LI1_ENST00000406852.3_Silent_p.L113L|DYNC2LI1_ENST00000605786.1_Silent_p.L113L	NM_001193464.1|NM_016008.3	NP_001180393.1|NP_057092.2	Q8TCX1	DC2L1_HUMAN	dynein, cytoplasmic 2, light intermediate chain 1	113						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|skin(1)	26		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTCTTGTTCTCGTTCTGGATC	0.333													8	23					0	0	1	0	0	T	44021614	C	T	44021614	2	4	48	1	0	0	0	0	0	0	0	1	4873	871	31	1		1	DYNC2LI1	2	44021614	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	222663	44021614	199177759	493	4887										
ABCG8	64241	broad.mit.edu	37	chr2	44073297	44073297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgatatctccccacaggtgGacctggcctctcaggtccct	9	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:44073297G>A	ENST00000272286.2	+	3	259	c.169G>A	c.(169-171)Gac>Aac	p.D57N		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	57	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CCCACAGGTGGACCTGGCCTC	0.547													28	35					0	0	1	0	0	A	44073297	G	A	44073297	3	1	48	1	0	0	0	0	1	0	0	0	72	1174	41	3	179	3	ABCG8	2	44073297	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	51683	44073297	199126076	494	4888										
LRPPRC	10128	broad.mit.edu	37	chr2	44170828	44170828	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaattcaattaacttacttTtccaagtgtacagtgaccaa	4	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:44170828T>G	ENST00000260665.7	-	23	2559	c.2502A>C	c.(2500-2502)gaA>gaC	p.E834D		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	834					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TAACTTACTTTTCCAAGTGTA	0.338													10	51					0	0	1	0	0	G	44170828	T	G	44170828	3	3	48	1	0	0	0	0	1	0	0	0	9009	1838	64	4	1746	4	LRPPRC	2	44170828	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	97531	44170828	199028545	495	4889										
LRPPRC	10128	broad.mit.edu	37	chr2	44187698	44187698	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaaatgataatacaaagtCtaagttcccatttgctgctt	5	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:44187698C>A	ENST00000260665.7	-	13	1621	c.1564G>T	c.(1564-1566)Gac>Tac	p.D522Y	LRPPRC_ENST00000409946.1_Missense_Mutation_p.D522Y	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	522					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AATACAAAGTCTAAGTTCCCA	0.363													7	57					1.12685e-05	1.24509e-05	1	1	0	A	44187698	C	A	44187698	3	1	48	1	0	0	0	0	1	0	0	0	9009	913	32	2	2724	2	LRPPRC	2	44187698	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16870	44187698	199011675	496	4890										
SRBD1	55133	broad.mit.edu	37	chr2	45620089	45620089	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttcaactgtttacctgttCgaaagtcaaagctttcaggc	8	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:45620089C>T	ENST00000263736.4	-	20	2755	c.2693G>A	c.(2692-2694)cGa>cAa	p.R898Q	SRBD1_ENST00000535761.1_Missense_Mutation_p.R417Q|SRBD1_ENST00000490133.1_5'UTR	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	898					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TTTACCTGTTCGAAAGTCAAA	0.413													41	74					0	0	1	0	0	T	45620089	C	T	45620089	3	4	48	1	0	0	0	0	1	0	0	0	15188	884	31	1	302	1	SRBD1	2	45620089	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1432391	45620089	197579284	497	4891										
SRBD1	55133	broad.mit.edu	37	chr2	45645642	45645642	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctctcgccattcaataAtatttttggccctgttggca	6	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:45645642A>C	ENST00000263736.4	-	18	2257	c.2195T>G	c.(2194-2196)aTt>aGt	p.I732S	SRBD1_ENST00000535761.1_Missense_Mutation_p.I251S|SRBD1_ENST00000490133.1_5'UTR	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	732					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CCATTCAATAATATTTTTGGC	0.388													23	40					0	0	1	0	0	C	45645642	A	C	45645642	3	2	48	1	0	0	0	0	1	0	0	0	15188	101	4	4	808	4	SRBD1	2	45645642	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	25553	45645642	197553731	498	4892										
PIGF	5281	broad.mit.edu	37	chr2	46842208	46842208	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttccaatattgagaagttCtccaagaagagtgatggaat	10	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:46842208C>A	ENST00000281382.6	-	2	266	c.96G>T	c.(94-96)gaG>gaT	p.E32D	PIGF_ENST00000306465.4_Missense_Mutation_p.E32D|PIGF_ENST00000495933.1_5'UTR	NM_002643.3	NP_002634.1	Q07326	PIGF_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class F	32					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	ethanolaminephosphotransferase activity			breast(1)|endometrium(1)|lung(1)|stomach(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TTGAGAAGTTCTCCAAGAAGA	0.343													30	62					1.06801e-11	1.33247e-11	1	1	0	A	46842208	C	A	46842208	3	1	48	1	0	0	0	0	1	0	0	0	11934	912	32	2	662	2	PIGF	2	46842208	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1196566	46842208	196357165	499	4893										
CRIPT	9419	broad.mit.edu	37	chr2	46851312	46851312	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgtttcaggcatctgtgcGatgtgtggaaaaaaggtttt	12	4	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:46851312G>A	ENST00000238892.3	+	5	384	c.252G>A	c.(250-252)gcG>gcA	p.A84A	CRIPT_ENST00000486447.1_3'UTR	NM_014171.4	NP_054890.1	Q9P021	CRIPT_HUMAN	cysteine-rich PDZ-binding protein	84						cell junction|cytoplasm|dendritic spine				kidney(1)|large_intestine(1)|lung(2)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GCATCTGTGCGATGTGTGGAA	0.328													10	37					0	0	1	0	0	A	46851312	G	A	46851312	2	1	48	1	0	0	0	0	0	0	0	1	3901	1045	37	1		1	CRIPT	2	46851312	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9104	46851312	196348061	500	4894										
SOCS5	0	broad.mit.edu	37	chr2	46986192	46986192	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagcagaactgtaggaagtCgctctctaagacagaggttg	12	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:46986192C>T	ENST00000306503.5	+	2	695	c.523C>T	c.(523-525)Cgc>Tgc	p.R175C	SOCS5_ENST00000394861.2_Missense_Mutation_p.R175C	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	175					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TGTAGGAAGTCGCTCTCTAAG	0.458													22	56					0	0	1	0	0	T	46986192	C	T	46986192	3	4	48	1	0	0	0	0	1	0	0	0	14970	884	31	1	525	1	SOCS5	2	46986192	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	134880	46986192	196213181	501	4895										
MSH6	2956	broad.mit.edu	37	chr2	48026710	48026710	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttacagtgtgctggaaggtGatccctctgagaactacagt	11	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:48026710G>T	ENST00000234420.4	+	4	1740	c.1588G>T	c.(1588-1590)Gat>Tat	p.D530Y	MSH6_ENST00000538136.1_Missense_Mutation_p.D228Y|FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Missense_Mutation_p.D400Y	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	530					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GCTGGAAGGTGATCCCTCTGA	0.428			"Mis, N, F, S"		colorectal	"colorectal, endometrial, ovarian"		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				26	42					9.04412e-07	1.02139e-06	1	1	0	T	48026710	G	T	48026710	3	4	48	1	0	0	0	0	1	0	0	0	9922	1290	45	2	1602	2	MSH6	2	48026710	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1040518	48026710	195172663	502	4896										
LHCGR	3973	broad.mit.edu	37	chr2	48914916	48914916	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacttcaaggtggattgagAaggcttatttgatccagtga	11	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:48914916A>T	ENST00000294954.7	-	11	2041	c.2020T>A	c.(2020-2022)Tct>Act	p.S674T	LHCGR_ENST00000344775.3_Missense_Mutation_p.S612T|LHCGR_ENST00000405626.1_Missense_Mutation_p.S647T|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000401907.1_3'UTR|LHCGR_ENST00000403273.1_3'UTR	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	674					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTGGATTGAGAAGGCTTATTT	0.428													20	80					0	0	1	0	0	T	48914916	A	T	48914916	3	4	48	1	0	0	0	0	1	0	0	0	8801	246	9	4	83	4	LHCGR	2	48914916	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	888206	48914916	194284457	503	4897										
LHCGR	3973	broad.mit.edu	37	chr2	48915866	48915866	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctaaggaagtcatagcccAtaatatcttcacagggatta	7	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:48915866A>G	ENST00000294954.7	-	11	1091	c.1070T>C	c.(1069-1071)aTg>aCg	p.M357T	LHCGR_ENST00000344775.3_Missense_Mutation_p.M295T|LHCGR_ENST00000405626.1_Missense_Mutation_p.M330T|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000401907.1_Intron|LHCGR_ENST00000403273.1_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	357					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTCATAGCCCATAATATCTTC	0.428													39	51					0	0	1	0	0	G	48915866	A	G	48915866	3	3	48	1	0	0	0	0	1	0	0	0	8801	217	8	4	1033	4	LHCGR	2	48915866	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	950	48915866	194283507	504	4898										
FSHR	0	broad.mit.edu	37	chr2	49195948	49195948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttttttaagttgtaagtcGacctggccctcagcttctta	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:49195948G>A	ENST00000406846.2	-	9	862	c.743C>T	c.(742-744)tCg>tTg	p.S248L	FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000304421.4_Missense_Mutation_p.S222L|FSHR_ENST00000346173.3_Intron|FSHR_ENST00000541117.1_5'UTR	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	248					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding	p.S248*(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GTTGTAAGTCGACCTGGCCCT	0.443									Gonadal Dysgenesis, 46 XX				10	41					0	0	1	0	0	A	49195948	G	A	49195948	3	1	48	1	0	0	0	0	1	0	0	0	6107	1059	37	1	1352	1	FSHR	2	49195948	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	280082	49195948	194003425	505	4899										
NRXN1	9378	broad.mit.edu	37	chr2	50724487	50724487	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaccctttaactaattcaaCcacaataaagtcatttccat	1	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:50724487C>T	ENST00000404971.1	-	15	4322	c.2983G>A	c.(2983-2985)Gtt>Att	p.V995I	NRXN1_ENST00000405472.3_Missense_Mutation_p.V947I|NRXN1_ENST00000406859.3_Missense_Mutation_p.V955I|NRXN1_ENST00000401669.2_Missense_Mutation_p.V955I|NRXN1_ENST00000402717.3_Missense_Mutation_p.V947I|NRXN1_ENST00000406316.2_Missense_Mutation_p.V955I|NRXN1_ENST00000331040.5_5'UTR	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	955	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTAATTCAACCACAATAAAG	0.338													4	37					0	0	1	0	0	T	50724487	C	T	50724487	3	4	48	1	0	0	0	0	1	0	0	0	10712	507	18	3	1963	3	NRXN1	2	50724487	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1528539	50724487	192474886	506	4900										
SPTBN1	0	broad.mit.edu	37	chr2	54858519	54858519	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacatcaagaacgagatcgAcaactacgaggaggactacc	10	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:54858519A>G	ENST00000333896.5	+	15	3681	c.3296A>G	c.(3295-3297)gAc>gGc	p.D1099G	SPTBN1_ENST00000356805.4_Missense_Mutation_p.D1112G	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1112					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AACGAGATCGACAACTACGAG	0.587													46	95					0	0	1	0	0	G	54858519	A	G	54858519	3	3	48	1	0	0	0	0	1	0	0	0	15174	275	10	4	3506	4	SPTBN1	2	54858519	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4134032	54858519	188340854	507	4901										
CCDC88A	55704	broad.mit.edu	37	chr2	55561822	55561822	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatgcttgcacacttcaaaGattctacattccttcgcagt	5	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:55561822G>T	ENST00000436346.1	-	15	2976	c.2135C>A	c.(2134-2136)tCt>tAt	p.S712Y	AC012358.8_ENST00000594078.1_RNA|AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000599352.1_RNA|CCDC88A_ENST00000336838.6_Missense_Mutation_p.S712Y|CCDC88A_ENST00000263630.8_Missense_Mutation_p.S712Y|CCDC88A_ENST00000413716.2_Missense_Mutation_p.S712Y|AC012358.8_ENST00000599475.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	712					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						ACACTTCAAAGATTCTACATT	0.378													17	34					2.48551e-13	3.17925e-13	1	1	0	T	55561822	G	T	55561822	3	4	48	1	0	0	0	0	1	0	0	0	2883	942	33	2	3552	2	CCDC88A	2	55561822	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	703303	55561822	187637551	508	4902										
CCDC88A	55704	broad.mit.edu	37	chr2	55646215	55646215	+	Translation_Start_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaaaaatttcgttctccaTtttacagagtatgtatttga	6	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:55646215T>C	ENST00000436346.1	-	1	842	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	CCDC88A_ENST00000471947.1_5'UTR|CCDC88A_ENST00000263630.8_Start_Codon_SNP_p.M1V|CCDC88A_ENST00000413716.2_Start_Codon_SNP_p.M1V|CCDC88A_ENST00000336838.6_Start_Codon_SNP_p.M1V	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TCGTTCTCCATTTTACAGAGT	0.388													13	22					0	0	1	0	0	C	55646215	T	C	55646215	1	2	48	1	0	0	0	0	0	0	0	0	2883	1493	52	4		4	CCDC88A	2	55646215	Translation_Start_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	84393	55646215	187553158	509	4903										
EFEMP1	2202	broad.mit.edu	37	chr2	56102133	56102133	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctgggggcacatacatgaGaatttcccaggttcattgac	10	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:56102133G>T	ENST00000394555.2	-	8	1383	c.948C>A	c.(946-948)ttC>ttA	p.F316L	EFEMP1_ENST00000424836.2_Missense_Mutation_p.F178L|EFEMP1_ENST00000394554.1_Missense_Mutation_p.F316L|EFEMP1_ENST00000355426.3_Missense_Mutation_p.F316L	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	316	EGF-like 5; calcium-binding (Potential).|Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACATACATGAGAATTTCCCAG	0.383													23	26					7.33628e-21	1.00811e-20	1	1	0	T	56102133	G	T	56102133	3	4	48	1	0	0	0	0	1	0	0	0	4967	933	33	2	549	2	EFEMP1	2	56102133	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	455918	56102133	187097240	510	4904										
BCL11A	53335	broad.mit.edu	37	chr2	60689471	60689471	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtagattcttaatccatgAgtgttctgtgcgtgttgcaa	10	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:60689471A>G	ENST00000335712.6	-	4	803	c.576T>C	c.(574-576)acT>acC	p.T192T	BCL11A_ENST00000358510.4_Silent_p.T158T|BCL11A_ENST00000537768.1_Silent_p.T40T|BCL11A_ENST00000359629.5_Silent_p.T192T|BCL11A_ENST00000538214.1_Silent_p.T158T|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Silent_p.T192T	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	192	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TTAATCCATGAGTGTTCTGTG	0.488			T	IGH@	B-CLL								15	50					0	0	1	0	0	G	60689471	A	G	60689471	2	3	48	1	0	0	0	0	0	0	0	1	1361	291	11	4		4	BCL11A	2	60689471	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4587338	60689471	182509902	511	4905										
REL	5966	broad.mit.edu	37	chr2	61118857	61118857	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagataattgaacaacccaGgcagaggggaatgcgtttta	12	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:61118857G>A	ENST00000295025.7	+	2	370	c.50G>A	c.(49-51)aGg>aAg	p.R17K	REL_ENST00000394479.3_Missense_Mutation_p.R17K	NM_002908.2	NP_002899.1	Q04864	REL_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog	17	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(3)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	16	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			GAACAACCCAGGCAGAGGGGA	0.418			A		Hodgkin Lymphoma								31	44					0	0	1	0	0	A	61118857	G	A	61118857	3	1	48	1	0	0	0	0	1	0	0	0	13266	1000	35	3	56	3	REL	2	61118857	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	429386	61118857	182080516	512	4906										
PUS10	150962	broad.mit.edu	37	chr2	61189976	61189976	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttacttaaggaaatcctctTcctttatcttattcaaggct	4	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:61189976T>C	ENST00000316752.6	-	9	1034	c.773A>G	c.(772-774)gAa>gGa	p.E258G	PUS10_ENST00000407787.1_Missense_Mutation_p.E258G	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	258					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			GAAATCCTCTTCCTTTATCTT	0.313													7	5					0	0	1	0	0	C	61189976	T	C	61189976	3	2	48	1	0	0	0	0	1	0	0	0	12882	1783	62	4	856	4	PUS10	2	61189976	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	71119	61189976	182009397	513	4907										
KIAA1841	84542	broad.mit.edu	37	chr2	61331021	61331021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggaccacatggttacacttCgtgatcaaggtgaaggcgga	14	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:61331021C>T	ENST00000402291.1	+	13	1640	c.1399C>T	c.(1399-1401)Cgt>Tgt	p.R467C	KIAA1841_ENST00000356719.2_Missense_Mutation_p.R467C|KIAA1841_ENST00000295031.5_Missense_Mutation_p.R467C|KIAA1841_ENST00000453873.1_Missense_Mutation_p.R467C	NM_001129993.1	NP_001123465.1	Q6NSI8	K1841_HUMAN	KIAA1841	467										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			GGTTACACTTCGTGATCAAGG	0.418													14	20					0	0	1	0	0	T	61331021	C	T	61331021	3	4	48	1	0	0	0	0	1	0	0	0	8302	884	31	1	1441	1	KIAA1841	2	61331021	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	141045	61331021	181868352	514	4908										
USP34	9736	broad.mit.edu	37	chr2	61415812	61415812	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctcatcactgctaacacGccgccttttaatgggagttg	8	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:61415812G>A	ENST00000398571.2	-	80	10142	c.10066C>T	c.(10066-10068)Cgt>Tgt	p.R3356C		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3356					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			CTGCTAACACGCCGCCTTTTA	0.478													21	20					0	0	1	0	0	A	61415812	G	A	61415812	3	1	48	1	0	0	0	0	1	0	0	0	17124	1087	38	1	578	1	USP34	2	61415812	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	84791	61415812	181783561	515	4909										
USP34	9736	broad.mit.edu	37	chr2	61575414	61575414	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attatgaccatgatcatcgtCttcatcttcctctttgaggg	7	10	5	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:61575414C>A	ENST00000398571.2	-	15	1952	c.1876G>T	c.(1876-1878)Gac>Tac	p.D626Y		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	626					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TGATCATCGTCTTCATCTTCC	0.488													22	37					4.35082e-09	5.20082e-09	1	1	0	A	61575414	C	A	61575414	3	1	48	1	0	0	0	0	1	0	0	0	17124	913	32	2	9028	2	USP34	2	61575414	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	159602	61575414	181623959	516	4910										
XPO1	7514	broad.mit.edu	37	chr2	61717829	61717829	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgattagggagtaacatgTacttttctatcaagtgttct	8	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:61717829T>C	ENST00000401558.2	-	17	2697	c.1970A>G	c.(1969-1971)tAc>tGc	p.Y657C	XPO1_ENST00000404992.2_Missense_Mutation_p.Y657C|XPO1_ENST00000406957.1_Missense_Mutation_p.Y657C	NM_003400.3	NP_003391.1	O14980	XPO1_HUMAN	exportin 1 (CRM1 homolog, yeast)	657	Necessary for HTLV-1 Rex-mediated mRNA export.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			GAGTAACATGTACTTTTCTAT	0.353			Mis		CLL								11	60					0	0	1	0	0	C	61717829	T	C	61717829	3	2	48	1	0	0	0	0	1	0	0	0	17504	1638	57	4	1281	4	XPO1	2	61717829	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	142415	61717829	181481544	517	4911										
FAM161A	84140	broad.mit.edu	37	chr2	62063239	62063239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctcatcctttccttttcgCtctttctaaaattaaagaaa	2	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:62063239C>T	ENST00000404929.1	-	5	1768	c.1757G>A	c.(1756-1758)aGc>aAc	p.S586N	FAM161A_ENST00000405894.3_Missense_Mutation_p.S530N	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	540					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTCCTTTTCGCTCTTTCTAAA	0.308													4	107					0	0	1	0	0	T	62063239	C	T	62063239	3	4	48	1	0	0	0	0	1	0	0	0	5502	797	28	3	405	3	FAM161A	2	62063239	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	345410	62063239	181136134	518	4912										
CCT4	10575	broad.mit.edu	37	chr2	62112207	62112207	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctaatagcatcagcaaccGctgcagatgggggggaaaaa	12	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:62112207G>A	ENST00000394440.3	-	2	424	c.127_splice	c.e2-1	p.A43_splice	AC107081.5_ENST00000425779.1_RNA|CCT4_ENST00000544079.1_Splice_Site_p.A43_splice|CCT4_ENST00000544185.1_5'UTR|CCT4_ENST00000538252.1_5'UTR	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	43					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			ATCAGCAACCGCTGCAGATGG	0.393													6	37					0	0	1	0	0	A	62112207	G	A	62112207	5	1	48	1	0	0	0	0	0	0	1	0	2977	1101	38	1	1543	1	CCT4	2	62112207	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	48968	62112207	181087166	519	4913										
UGP2	7360	broad.mit.edu	37	chr2	64083494	64083494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagttccaagaagtcattcGgcaagagctagaattatctg	9	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:64083494G>A	ENST00000337130.5	+	2	550	c.74G>A	c.(73-75)cGg>cAg	p.R25Q	UGP2_ENST00000487469.1_Intron|UGP2_ENST00000445915.2_Missense_Mutation_p.R34Q|UGP2_ENST00000394417.2_Missense_Mutation_p.R14Q|UGP2_ENST00000467648.2_Missense_Mutation_p.R14Q	NM_006759.3	NP_006750.3	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2	25				R -> L (in Ref. 1).	glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)	18						GAAGTCATTCGGCAAGAGCTA	0.398													57	112					0	0	1	0	0	A	64083494	G	A	64083494	3	1	48	1	0	0	0	0	1	0	0	0	17002	1116	39	1	80	1	UGP2	2	64083494	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1971287	64083494	179115879	520	4914										
AFTPH	54812	broad.mit.edu	37	chr2	64779068	64779068	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaaagtttctctccaggaGattttagaactaatatgaat	7	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:64779068G>T	ENST00000422803.1	+	2	774	c.460G>T	c.(460-462)Gat>Tat	p.D154Y	AFTPH_ENST00000409933.1_Missense_Mutation_p.D154Y|AFTPH_ENST00000238856.4_Missense_Mutation_p.D154Y|AFTPH_ENST00000238855.7_Missense_Mutation_p.D154Y			Q6ULP2	AFTIN_HUMAN	aftiphilin	154					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						CTCTCCAGGAGATTTTAGAAC	0.388													16	38					3.45872e-05	3.78815e-05	1	1	0	T	64779068	G	T	64779068	3	4	48	1	0	0	0	0	1	0	0	0	363	942	33	2	462	2	AFTPH	2	64779068	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	695574	64779068	178420305	521	4915										
SLC1A4	6509	broad.mit.edu	37	chr2	65231096	65231096	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgatcacagtatgcaaccGattataaagtcgtgacccag	8	10	1	2	rs140402535		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:65231096G>A	ENST00000234256.3	+	3	823	c.580G>A	c.(580-582)Gat>Aat	p.D194N	SLC1A4_ENST00000493121.1_3'UTR|SLC1A4_ENST00000531327.1_5'UTR	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	194					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	GTATGCAACCGATTATAAAGT	0.408													4	32					0	0	1	0	0	A	65231096	G	A	65231096	3	1	48	1	0	0	0	0	1	0	0	0	14488	1058	37	1	590	1	SLC1A4	2	65231096	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	452028	65231096	177968277	522	4916										
ETAA1	54465	broad.mit.edu	37	chr2	67630550	67630550	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattacataatatagttcccGaaatagataatgctacaaaa	4	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:67630550G>A	ENST00000272342.5	+	5	866	c.736G>A	c.(736-738)Gaa>Aaa	p.E246K	ETAA1_ENST00000462772.1_Intron	NM_019002.3	NP_061875.2	Q9NY74	ETAA1_HUMAN	Ewing tumor-associated antigen 1	246						cytoplasm|nucleus				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	33						TATAGTTCCCGAAATAGATAA	0.313													25	52					0	0	1	0	0	A	67630550	G	A	67630550	3	1	48	1	0	0	0	0	1	0	0	0	5295	1059	37	1	754	1	ETAA1	2	67630550	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2399454	67630550	175568823	523	4917										
PLEK	5341	broad.mit.edu	37	chr2	68607896	68607896	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accaaacagcaggaccacttCttccaggcagccttcctgga	8	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:68607896C>A	ENST00000234313.7	+	3	419	c.240C>A	c.(238-240)ttC>ttA	p.F80L		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	80	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGGACCACTTCTTCCAGGCAG	0.463													62	102					6.2918e-36	9.04828e-36	1	1	0	A	68607896	C	A	68607896	3	1	48	1	0	0	0	0	1	0	0	0	12100	912	32	2	250	2	PLEK	2	68607896	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	977346	68607896	174591477	524	4918										
PLEK	5341	broad.mit.edu	37	chr2	68613778	68613778	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcagtggatggaactgctgAaaaccctttcctggacaacc	10	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:68613778A>G	ENST00000234313.7	+	5	796	c.617A>G	c.(616-618)gAa>gGa	p.E206G		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	206	DEP.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GGAACTGCTGAAAACCCTTTC	0.507													34	64					0	0	1	0	0	G	68613778	A	G	68613778	3	3	48	1	0	0	0	0	1	0	0	0	12100	246	9	4	635	4	PLEK	2	68613778	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5882	68613778	174585595	525	4919										
PLEK	5341	broad.mit.edu	37	chr2	68622924	68622924	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtggatcagagccatccaGatggcctcccgaactgggaa	13	11	1	2	rs149225658	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:68622924G>A	ENST00000234313.7	+	9	1208	c.1029G>A	c.(1027-1029)caG>caA	p.Q343Q		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	343	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GAGCCATCCAGATGGCCTCCC	0.537													16	41					0	0	1	0	0	A	68622924	G	A	68622924	2	1	48	1	0	0	0	0	0	0	0	1	12100	933	33	3		3	PLEK	2	68622924	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9146	68622924	174576449	526	4920										
BMP10	27302	broad.mit.edu	37	chr2	69093648	69093648	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgaggaatggacacattGaagaggagggggtattttcg	17	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:69093648G>T	ENST00000295379.1	-	2	548	c.390C>A	c.(388-390)ttC>ttA	p.F130L		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	130					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						TGGACACATTGAAGAGGAGGG	0.453													17	25					6.94344e-10	8.4399e-10	1	1	0	T	69093648	G	T	69093648	3	4	48	1	0	0	0	0	1	0	0	0	1456	1281	45	2	888	2	BMP10	2	69093648	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	470724	69093648	174105725	527	4921										
NFU1	27247	broad.mit.edu	37	chr2	69633160	69633160	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaggagcacgtaccgtattCtagtatctaacaattcctta	7	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:69633160C>A	ENST00000410022.2	-	6	744	c.539G>T	c.(538-540)aGa>aTa	p.R180I	NFU1_ENST00000462320.1_Missense_Mutation_p.R39I|NFU1_ENST00000471185.1_5'UTR|NFU1_ENST00000303698.3_Missense_Mutation_p.R156I|NFU1_ENST00000394305.1_Missense_Mutation_p.R39I	NM_001002755.2	NP_001002755.1	Q9UMS0	NFU1_HUMAN	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	180	NifU.				iron-sulfur cluster assembly	cytosol|mitochondrion|nucleus	4 iron, 4 sulfur cluster binding|iron ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	7						GTACCGTATTCTAGTATCTAA	0.323													12	27					0.000978159	0.00102903	1	1	0	A	69633160	C	A	69633160	3	1	48	1	0	0	0	0	1	0	0	0	10432	913	32	2	237	2	NFU1	2	69633160	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	539512	69633160	173566213	528	4922										
TIA1	7072	broad.mit.edu	37	chr2	70441492	70441492	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgcttacttaaatccttgCtggttccatgcctggccata	7	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:70441492C>A	ENST00000433529.2	-	12	1233	c.1023G>T	c.(1021-1023)caG>caT	p.Q341H	TIA1_ENST00000445587.1_Intron|TIA1_ENST00000415783.2_Missense_Mutation_p.Q330H|TIA1_ENST00000282574.4_Missense_Mutation_p.Q340H|C2orf42_ENST00000470096.1_Intron	NM_022173.2	NP_071505.2	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein	341					apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	17						TAAATCCTTGCTGGTTCCATG	0.378													14	21					6.72482e-11	8.31618e-11	1	1	0	A	70441492	C	A	70441492	3	1	48	1	0	0	0	0	1	0	0	0	15946	796	28	5	145	5	TIA1	2	70441492	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	808332	70441492	172757881	529	4923										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360050	71360050	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaagagggattggcatcaAagttcacttctttaacaaaa	7	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71360050A>C	ENST00000244230.2	+	2	464	c.112A>C	c.(112-114)Aag>Cag	p.K38Q	MPHOSPH10_ENST00000498451.2_Missense_Mutation_p.K38Q|MPHOSPH10_ENST00000468427.1_3'UTR	NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	38					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						ATTGGCATCAAAGTTCACTTC	0.313													10	30					0	0	1	0	0	C	71360050	A	C	71360050	3	2	48	1	0	0	0	0	1	0	0	0	9773	15	1	4	118	4	MPHOSPH10	2	71360050	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	918558	71360050	171839323	530	4924										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360080	71360080	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttaacaaaagtgctttatGactttaataaaatattagag	5	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71360080G>T	ENST00000244230.2	+	2	494	c.142G>T	c.(142-144)Gac>Tac	p.D48Y	MPHOSPH10_ENST00000498451.2_Missense_Mutation_p.D48Y|MPHOSPH10_ENST00000468427.1_3'UTR	NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	48					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						AGTGCTTTATGACTTTAATAA	0.338													15	27					6.31663e-08	7.35827e-08	1	1	0	T	71360080	G	T	71360080	3	4	48	1	0	0	0	0	1	0	0	0	9773	1290	45	2	148	2	MPHOSPH10	2	71360080	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30	71360080	171839293	531	4925										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360500	71360500	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacagcagagcaaggtgcaaAacaaaggacagggaaaacca	11	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71360500A>C	ENST00000244230.2	+	2	914	c.562A>C	c.(562-564)Aac>Cac	p.N188H	MPHOSPH10_ENST00000498451.2_Missense_Mutation_p.N188H	NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	188					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						CAAGGTGCAAAACAAAGGACA	0.388													23	58					0	0	1	0	0	C	71360500	A	C	71360500	3	2	48	1	0	0	0	0	1	0	0	0	9773	14	1	4	568	4	MPHOSPH10	2	71360500	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	420	71360500	171838873	532	4926										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71368389	71368389	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatgtagtacgtaaagaaAaacctaaagaggatgcatat	9	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71368389A>C	ENST00000244230.2	+	7	1688	c.1336A>C	c.(1336-1338)Aaa>Caa	p.K446Q		NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	446					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						ACGTAAAGAAAAACCTAAAGA	0.343													55	107					0	0	1	0	0	C	71368389	A	C	71368389	3	2	48	1	0	0	0	0	1	0	0	0	9773	15	1	4	1362	4	MPHOSPH10	2	71368389	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7889	71368389	171830984	533	4927										
ZNF638	27332	broad.mit.edu	37	chr2	71654320	71654320	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttaaagaagagcttaattTtgttactgttgatgaagttg	9	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71654320T>G	ENST00000409544.1	+	24	5951	c.5321T>G	c.(5320-5322)tTt>tGt	p.F1774C	ZNF638_ENST00000409407.1_Missense_Mutation_p.F714C|ZNF638_ENST00000264447.4_Missense_Mutation_p.F1774C|ZNF638_ENST00000355812.3_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1774					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GAGCTTAATTTTGTTACTGTT	0.373													35	64					0	0	1	0	0	G	71654320	T	G	71654320	3	3	48	1	0	0	0	0	1	0	0	0	18111	1841	64	4	5411	4	ZNF638	2	71654320	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	285931	71654320	171545053	534	4928										
DYSF	8291	broad.mit.edu	37	chr2	71801397	71801397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggctggaagttccacctcGagtaccgcaagacagatgcc	11	12	0	2	rs144599077		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71801397G>A	ENST00000258104.3	+	30	3521	c.3244G>A	c.(3244-3246)Gag>Aag	p.E1082K	DYSF_ENST00000409582.3_Missense_Mutation_p.E1099K|DYSF_ENST00000410041.1_Missense_Mutation_p.E1100K|DYSF_ENST00000413539.2_Missense_Mutation_p.E1113K|DYSF_ENST00000409744.1_Missense_Mutation_p.E1069K|DYSF_ENST00000429174.2_Missense_Mutation_p.E1082K|DYSF_ENST00000409762.1_Missense_Mutation_p.E1099K|DYSF_ENST00000409651.1_Missense_Mutation_p.E1114K|DYSF_ENST00000410020.3_Missense_Mutation_p.E1100K|DYSF_ENST00000409366.1_Missense_Mutation_p.E1083K|DYSF_ENST00000394120.2_Missense_Mutation_p.E1083K	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1082	Arg-rich.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GTTCCACCTCGAGTACCGCAA	0.662													56	108					0	0	1	0	0	A	71801397	G	A	71801397	3	1	48	1	0	0	0	0	1	0	0	0	4885	1059	37	1	3554	1	DYSF	2	71801397	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	147077	71801397	171397976	535	4929										
DYSF	8291	broad.mit.edu	37	chr2	71825739	71825739	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaccagagccagaagacggTggtggtgaagaacaccctta	13	10	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:71825739T>C	ENST00000258104.3	+	33	3843	c.3566T>C	c.(3565-3567)gTg>gCg	p.V1189A	DYSF_ENST00000409582.3_Missense_Mutation_p.V1206A|DYSF_ENST00000410041.1_Missense_Mutation_p.V1207A|DYSF_ENST00000413539.2_Missense_Mutation_p.V1220A|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000409744.1_Missense_Mutation_p.V1176A|DYSF_ENST00000429174.2_Missense_Mutation_p.V1189A|DYSF_ENST00000409762.1_Missense_Mutation_p.V1206A|DYSF_ENST00000409651.1_Missense_Mutation_p.V1221A|DYSF_ENST00000410020.3_Missense_Mutation_p.V1207A|DYSF_ENST00000409366.1_Missense_Mutation_p.V1190A|DYSF_ENST00000394120.2_Missense_Mutation_p.V1190A	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1189	C2 4.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CAGAAGACGGTGGTGGTGAAG	0.607													13	55					0	0	1	0	0	C	71825739	T	C	71825739	3	2	48	1	0	0	0	0	1	0	0	0	4885	1696	59	4	3888	4	DYSF	2	71825739	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	24342	71825739	171373634	536	4930										
EXOC6B	23233	broad.mit.edu	37	chr2	72740314	72740314	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtgccatttcccacagttCatcaatgtaggctctattta	6	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:72740314C>A	ENST00000272427.6	-	11	1244	c.1114G>T	c.(1114-1116)Gaa>Taa	p.E372*	EXOC6B_ENST00000410104.1_Nonsense_Mutation_p.E372*	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	372					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						TCCCACAGTTCATCAATGTAG	0.408													21	30					6.33239e-15	8.29613e-15	1	1	0	A	72740314	C	A	72740314	4	1	48	1	0	0	0	0	0	1	0	0	5336	835	29	2	1369	2	EXOC6B	2	72740314	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	914575	72740314	170459059	537	4931										
EXOC6B	23233	broad.mit.edu	37	chr2	72945368	72945368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaccatcaccttgcagaatCgatagtggcttacttgaggc	9	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:72945368C>T	ENST00000272427.6	-	6	663	c.533G>A	c.(532-534)cGa>cAa	p.R178Q	EXOC6B_ENST00000410104.1_Missense_Mutation_p.R178Q	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	178					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						CTTGCAGAATCGATAGTGGCT	0.433													21	38					0	0	1	0	0	T	72945368	C	T	72945368	3	4	48	1	0	0	0	0	1	0	0	0	5336	884	31	1	1970	1	EXOC6B	2	72945368	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	205054	72945368	170254005	538	4932										
ALMS1	7840	broad.mit.edu	37	chr2	73675274	73675274	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgatactctcaaccaaaaGacattagcagatactcatct	4	11	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:73675274G>T	ENST00000264448.6	+	8	1728	c.1617G>T	c.(1615-1617)aaG>aaT	p.K539N	ALMS1_ENST00000409009.1_Missense_Mutation_p.K497N|ALMS1_ENST00000377715.1_Missense_Mutation_p.K539N	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	539	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TCAACCAAAAGACATTAGCAG	0.428													31	44					1.08312e-15	1.43e-15	1	1	0	T	73675274	G	T	73675274	3	4	48	1	0	0	0	0	1	0	0	0	531	933	33	2	1647	2	ALMS1	2	73675274	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	729906	73675274	169524099	539	4933										
ALMS1	7840	broad.mit.edu	37	chr2	73679645	73679645	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacataaagagaaactcaaGatttcaactgtgcatatacc	5	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:73679645G>T	ENST00000264448.6	+	8	6099	c.5988G>T	c.(5986-5988)aaG>aaT	p.K1996N	ALMS1_ENST00000409009.1_Missense_Mutation_p.K1954N|ALMS1_ENST00000377715.1_Missense_Mutation_p.K1996N	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1996	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						AGAAACTCAAGATTTCAACTG	0.413													17	102					9.7654e-05	0.000105618	1	1	0	T	73679645	G	T	73679645	3	4	48	1	0	0	0	0	1	0	0	0	531	933	33	2	6018	2	ALMS1	2	73679645	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4371	73679645	169519728	540	4934										
NAT8	9027	broad.mit.edu	37	chr2	73868634	73868634	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagtaagagtatgagggttCgaggcagcttcagcaattgc	13	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:73868634C>T	ENST00000272425.3	-	2	271	c.122G>A	c.(121-123)cGa>cAa	p.R41Q		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	41					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						TATGAGGGTTCGAGGCAGCTT	0.622													51	71					0	0	1	0	0	T	73868634	C	T	73868634	3	4	48	1	0	0	0	0	1	0	0	0	10226	884	31	1	565	1	NAT8	2	73868634	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	188989	73868634	169330739	541	4935										
DUSP11	8446	broad.mit.edu	37	chr2	73989834	73989834	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataggagagtctggagtaaTtataaggataccaccttctt	10	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:73989834T>G	ENST00000272444.3	-	9	1129	c.1088A>C	c.(1087-1089)aAt>aCt	p.N363T	DUSP11_ENST00000480948.1_5'UTR	NM_003584.2	NP_003575.2	O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	316					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						TCTGGAGTAATTATAAGGATA	0.502													8	73					0	0	1	0	0	G	73989834	T	G	73989834	3	3	48	1	0	0	0	0	1	0	0	0	4837	1493	52	4	49	4	DUSP11	2	73989834	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	121200	73989834	169209539	542	4936										
DUSP11	8446	broad.mit.edu	37	chr2	74000942	74000942	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaccattatctttattttCtttcaaaaacccattaacag	1	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:74000942C>A	ENST00000443070.1	-	4	564	c.559G>T	c.(559-561)Gaa>Taa	p.E187*	DUSP11_ENST00000377706.4_Nonsense_Mutation_p.E140*|DUSP11_ENST00000480948.1_5'UTR|DUSP11_ENST00000272444.3_Nonsense_Mutation_p.E187*			O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	140	Tyrosine-protein phosphatase.				RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						TCTTTATTTTCTTTCAAAAAC	0.328													39	62					2.6416e-12	3.32596e-12	1	1	0	A	74000942	C	A	74000942	4	1	48	1	0	0	0	0	0	1	0	0	4837	922	32	2	598	2	DUSP11	2	74000942	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11108	74000942	169198431	543	4937										
C2orf78	388960	broad.mit.edu	37	chr2	74043300	74043300	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgatatgaaaactggattCtcttcctccaggaccctggg	9	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:74043300C>A	ENST00000409561.1	+	3	2071	c.1950C>A	c.(1948-1950)ttC>ttA	p.F650L		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	650										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						AAACTGGATTCTCTTCCTCCA	0.512													19	61					1.15919e-05	1.28007e-05	1	1	0	A	74043300	C	A	74043300	3	1	48	1	0	0	0	0	1	0	0	0	2209	912	32	2	1960	2	C2orf78	2	74043300	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	42358	74043300	169156073	544	4938										
SLC4A5	57835	broad.mit.edu	37	chr2	74458402	74458402	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagacagagattcccgtcagGatgaagacgatgatgccggt	13	8	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:74458402G>T	ENST00000423644.1	-	24	3026	c.2629C>A	c.(2629-2631)Cct>Act	p.P877T	SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000394019.2_Silent_p.I936I|SLC4A5_ENST00000377632.1_Silent_p.I936I|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377634.4_Silent_p.I936I|SLC4A5_ENST00000358683.4_Silent_p.I834I|SLC4A5_ENST00000357822.5_Silent_p.I936I|SLC4A5_ENST00000346834.4_Silent_p.I936I|SLC4A5_ENST00000359484.4_Silent_p.I834I			Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	23						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TTCCCGTCAGGATGAAGACGA	0.557													21	50					5.26018e-13	6.70247e-13	1	1	0	T	74458402	G	T	74458402	3	4	48	1	0	0	0	0	1	0	0	0	14711	1164	41	2	633	2	SLC4A5	2	74458402	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	415102	74458402	168740971	545	4939										
SLC4A5	57835	broad.mit.edu	37	chr2	74477584	74477584	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatgtggaagccatcataGaagtcacttgggaaccaggg	13	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:74477584G>T	ENST00000394019.2	-	17	1936	c.1539C>A	c.(1537-1539)ttC>ttA	p.F513L	SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.F513L|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000377634.4_Missense_Mutation_p.F513L|SLC4A5_ENST00000358683.4_Missense_Mutation_p.F449L|SLC4A5_ENST00000357822.5_Missense_Mutation_p.F513L|SLC4A5_ENST00000346834.4_Missense_Mutation_p.F513L|SLC4A5_ENST00000423644.1_Missense_Mutation_p.F513L|SLC4A5_ENST00000359484.4_Missense_Mutation_p.F449L	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	513						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGCCATCATAGAAGTCACTTG	0.532											OREG0014716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	146					3.30226e-22	4.58371e-22	1	1	0	T	74477584	G	T	74477584	3	4	48	1	0	0	0	0	1	0	0	0	14711	933	33	2	1934	2	SLC4A5	2	74477584	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19182	74477584	168721789	546	4940										
WBP1	23559	broad.mit.edu	37	chr2	74687176	74687176	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggttcactgcttgaccttCgtgagtgacttgatgccctg	11	12	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:74687176C>T	ENST00000393972.3	+	4	654	c.451_splice	c.e4+1	p.R151_splice	WBP1_ENST00000409737.1_Splice_Site_p.R114_splice|WBP1_ENST00000494741.1_3'UTR|WBP1_ENST00000233615.2_Splice_Site_p.R117_splice			Q96G27	WBP1_HUMAN	WW domain binding protein 1	117							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						GCTTGACCTTCGTGAGTGACT	0.527													27	69					0	0	1	0	0	T	74687176	C	T	74687176	5	4	48	1	0	0	0	0	0	0	1	0	17316	898	31	1	359	1	WBP1	2	74687176	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	209592	74687176	168512197	547	4941										
MOGS	7841	broad.mit.edu	37	chr2	74688986	74688986	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctagctctggggcccagtGcagctcatccaggctctctg	11	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:74688986G>A	ENST00000233616.4	-	4	2092	c.1930C>T	c.(1930-1932)Cac>Tac	p.H644Y	MOGS_ENST00000452063.2_Missense_Mutation_p.H538Y|MOGS_ENST00000409065.1_3'UTR	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	644					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						GGGGCCCAGTGCAGCTCATCC	0.637													23	58					0	0	1	0	0	A	74688986	G	A	74688986	3	1	48	1	0	0	0	0	1	0	0	0	9745	1319	46	3	587	3	MOGS	2	74688986	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1810	74688986	168510387	548	4942										
TACR1	6869	broad.mit.edu	37	chr2	75425876	75425876	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttcgtcactgtcctcattCttttgtgggctaagatgatc	9	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:75425876C>A	ENST00000305249.4	-	1	950	c.185G>T	c.(184-186)aGa>aTa	p.R62I	TACR1_ENST00000409848.3_Missense_Mutation_p.R62I	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	62					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TGTCCTCATTCTTTTGTGGGC	0.522													17	38					4.7546e-09	5.67505e-09	1	1	0	A	75425876	C	A	75425876	3	1	48	1	0	0	0	0	1	0	0	0	15561	913	32	2	1062	2	TACR1	2	75425876	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	736890	75425876	167773497	549	4943										
MRPL19	9801	broad.mit.edu	37	chr2	75882241	75882241	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaaacgctgggaacgtccaAattttaatattaaaggaatc	7	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:75882241A>C	ENST00000393909.2	+	6	734	c.709A>C	c.(709-711)Aat>Cat	p.N237H	MRPL19_ENST00000358788.6_Intron|MRPL19_ENST00000409374.1_Missense_Mutation_p.N237H	NM_014763.3	NP_055578.2	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19	237					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(6)	8						GGAACGTCCAAATTTTAATAT	0.323													18	20					0	0	1	0	0	C	75882241	A	C	75882241	3	2	48	1	0	0	0	0	1	0	0	0	9832	14	1	4	731	4	MRPL19	2	75882241	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	456365	75882241	167317132	550	4944										
CTNNA2	1496	broad.mit.edu	37	chr2	80646632	80646632	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctggaaaccaatgttccttTgctagttctcattgaggctg	9	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:80646632T>C	ENST00000466387.1	+	13	1920	c.1196T>C	c.(1195-1197)tTg>tCg	p.L399S	CTNNA2_ENST00000402739.4_Missense_Mutation_p.L399S|CTNNA2_ENST00000496558.1_Missense_Mutation_p.L399S|CTNNA2_ENST00000361291.4_Missense_Mutation_p.L433S|CTNNA2_ENST00000541047.1_Missense_Mutation_p.L399S|CTNNA2_ENST00000540488.1_Missense_Mutation_p.L399S|CTNNA2_ENST00000343114.3_Missense_Mutation_p.L78S			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	399					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AATGTTCCTTTGCTAGTTCTC	0.393													24	51					0	0	1	0	0	C	80646632	T	C	80646632	3	2	48	1	0	0	0	0	1	0	0	0	4037	1821	63	4	1018	4	CTNNA2	2	80646632	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4764391	80646632	162552741	551	4945										
CTNNA2	1496	broad.mit.edu	37	chr2	80874726	80874726	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagctggacagtgccacatCgcttatccaggcagctaaaa	9	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:80874726C>T	ENST00000466387.1	+	22	3171	c.2447C>T	c.(2446-2448)tCg>tTg	p.S816L	CTNNA2_ENST00000402739.4_Missense_Mutation_p.S864L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.S816L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.S850L|CTNNA2_ENST00000541047.1_Missense_Mutation_p.S816L|CTNNA2_ENST00000540488.1_Missense_Mutation_p.S771L|CTNNA2_ENST00000343114.3_Missense_Mutation_p.S495L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	864					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AGTGCCACATCGCTTATCCAG	0.448													33	69					0	0	1	0	0	T	80874726	C	T	80874726	3	4	48	1	0	0	0	0	1	0	0	0	4037	893	31	1	2305	1	CTNNA2	2	80874726	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	228094	80874726	162324647	552	4946										
KCMF1	56888	broad.mit.edu	37	chr2	85255047	85255047	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgtttaaaaggaaattttCgaggtcgcagatataagtgt	10	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:85255047C>T	ENST00000409785.3	+	2	411	c.52C>T	c.(52-54)Cga>Tga	p.R18*		NM_020122.4	NP_064507.3	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	18						intracellular	ligase activity|zinc ion binding			ovary(3)	3						AGGAAATTTTCGAGGTCGCAG	0.353													12	17					0	0	1	0	0	T	85255047	C	T	85255047	4	4	48	1	0	0	0	0	0	1	0	0	8043	876	31	1	58	1	KCMF1	2	85255047	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4380321	85255047	157944326	553	4947										
GNLY	10578	broad.mit.edu	37	chr2	85924740	85924740	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagagttacccagggcctcGtggccggagaaactgcccag	13	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:85924740G>A	ENST00000409696.3	+	5	604	c.322G>A	c.(322-324)Gtg>Atg	p.V108M	GNLY_ENST00000524600.1_Missense_Mutation_p.V150M|GNLY_ENST00000263863.4_Missense_Mutation_p.V123M	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	123	Saposin B-type.				cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						CCAGGGCCTCGTGGCCGGAGA	0.567													22	38					0	0	1	0	0	A	85924740	G	A	85924740	3	1	48	1	0	0	0	0	1	0	0	0	6580	1145	40	1	392	1	GNLY	2	85924740	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	669693	85924740	157274633	554	4948										
PROM2	150696	broad.mit.edu	37	chr2	95950732	95950732	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagtataccaacaagctaCggcaggagttgcagagcctg	11	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:95950732C>T	ENST00000317620.9	+	15	1877	c.1744C>T	c.(1744-1746)Cgg>Tgg	p.R582W	PROM2_ENST00000317668.4_Missense_Mutation_p.R582W|PROM2_ENST00000542147.1_Intron|PROM2_ENST00000403131.2_Missense_Mutation_p.R582W	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	582						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						CAACAAGCTACGGCAGGAGTT	0.627													8	9					0	0	1	0	0	T	95950732	C	T	95950732	3	4	48	1	0	0	0	0	1	0	0	0	12607	527	19	1	1802	1	PROM2	2	95950732	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10025992	95950732	147248641	555	4949										
GPAT2	150763	broad.mit.edu	37	chr2	96690545	96690545	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatgcttgaagagcagcagCgttgccataatggccgtgct	13	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:96690545C>T	ENST00000434632.1	-	15	1863	c.1404G>A	c.(1402-1404)acG>acA	p.T468T	GPAT2_ENST00000453542.1_Silent_p.T397T|GPAT2_ENST00000359548.4_Silent_p.T468T|GPAT2_ENST00000377137.3_Silent_p.T468T			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	468					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						AGAGCAGCAGCGTTGCCATAA	0.657													80	166					0	0	1	0	0	T	96690545	C	T	96690545	2	4	48	1	0	0	0	0	0	0	0	1	6628	755	27	1		1	GPAT2	2	96690545	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	739813	96690545	146508828	556	4950										
ADRA2B	151	broad.mit.edu	37	chr2	96780585	96780585	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgggcggcacaggatcctcCggaaggcacggcggaagtcc	16	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:96780585C>T	ENST00000409345.3	-	1	1399	c.1304G>A	c.(1303-1305)cGg>cAg	p.R435Q		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	438					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CAGGATCCTCCGGAAGGCACG	0.632													13	17					0	0	1	0	0	T	96780585	C	T	96780585	3	4	48	1	0	0	0	0	1	0	0	0	337	652	23	1	43	1	ADRA2B	2	96780585	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	90040	96780585	146418788	557	4951										
STARD7	56910	broad.mit.edu	37	chr2	96858113	96858113	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggtaaaactcacctcatcAaatgacttgtggggacggat	11	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:96858113A>G	ENST00000337288.5	-	6	1220	c.837T>C	c.(835-837)ttT>ttC	p.F279F	STARD7_ENST00000462501.1_5'UTR	NM_020151.3	NP_064536.2	Q9NQZ5	STAR7_HUMAN	StAR-related lipid transfer (START) domain containing 7	279	START.					mitochondrion				endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|stomach(2)	14						TCACCTCATCAAATGACTTGT	0.488													40	75					0	0	1	0	0	G	96858113	A	G	96858113	2	3	48	1	0	0	0	0	0	0	0	1	15317	127	5	4		4	STARD7	2	96858113	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	77528	96858113	146341260	558	4952										
LMAN2L	81562	broad.mit.edu	37	chr2	97373532	97373532	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggggttctctccactgTcagttcaaacaacttcaagg	8	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:97373532T>C	ENST00000264963.4	-	7	845	c.823A>G	c.(823-825)Aca>Gca	p.T275A	LMAN2L_ENST00000537039.1_Missense_Mutation_p.T137A|LMAN2L_ENST00000534882.1_Missense_Mutation_p.T130A|LMAN2L_ENST00000426463.2_Missense_Mutation_p.T141A|LMAN2L_ENST00000377079.4_Missense_Mutation_p.T286A	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	275					ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						CTCTCCACTGTCAGTTCAAAC	0.453													24	67					0	0	1	0	0	C	97373532	T	C	97373532	3	2	48	1	0	0	0	0	1	0	0	0	8879	1667	58	4	231	4	LMAN2L	2	97373532	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	515419	97373532	145825841	559	4953										
LMAN2L	81562	broad.mit.edu	37	chr2	97405653	97405653	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaacgtttgacccgccccgActtgctgtggcccctgccca	10	18	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:97405653A>G	ENST00000264963.4	-	1	147	c.125T>C	c.(124-126)gTc>gCc	p.V42A	LMAN2L_ENST00000377079.4_Missense_Mutation_p.V42A|LMAN2L_ENST00000426463.2_5'UTR|LMAN2L_ENST00000537039.1_5'UTR|LMAN2L_ENST00000534882.1_5'UTR	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	42					ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						ACCCGCCCCGACTTGCTGTGG	0.632													37	67					0	0	1	0	0	G	97405653	A	G	97405653	3	3	48	1	0	0	0	0	1	0	0	0	8879	275	10	4	990	4	LMAN2L	2	97405653	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	32121	97405653	145793720	560	4954										
ANKRD36B	57730	broad.mit.edu	37	chr2	98169646	98169646	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attacctgtcccagatttttCtccatcctttatttctgtgg	5	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:98169646C>A	ENST00000443455.1	-	0	1368							Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B																		CCAGATTTTTCTCCATCCTTT	0.358													12	18					5.50884e-06	6.10489e-06	1	1	0	A	98169646	C	A	98169646	1	1	48	0	1	0	0	0	0	0	0	0	660	922	32	2		2	ANKRD36B	2	98169646	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	763993	98169646	145029727	561	4955										
ACTR1B	10120	broad.mit.edu	37	chr2	98277092	98277092	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccagccatcacccgcatgTgcttcggccgcccgacactg	9	19	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:98277092T>C	ENST00000289228.5	-	3	347	c.131A>G	c.(130-132)cAc>cGc	p.H44R		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	44						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						CACCCGCATGTGCTTCGGCCG	0.597													39	77					0	0	1	0	0	C	98277092	T	C	98277092	3	2	48	1	0	0	0	0	1	0	0	0	210	1696	59	4	1035	4	ACTR1B	2	98277092	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	107446	98277092	144922281	562	4956										
VWA3B	200403	broad.mit.edu	37	chr2	98928336	98928336	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggccactgaaagaagcGgacacgcaggattccagaga	12	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:98928336G>A	ENST00000477737.1	+	27	3780	c.3576G>A	c.(3574-3576)gcG>gcA	p.A1192A	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1192										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGAAAGAAGCGGACACGCAGG	0.602													7	17					0	0	1	0	0	A	98928336	G	A	98928336	2	1	48	1	0	0	0	0	0	0	0	1	17300	1103	39	1		1	VWA3B	2	98928336	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	651244	98928336	144271037	563	4957										
CNGA3	1261	broad.mit.edu	37	chr2	99006196	99006196	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccgctggctgaccgccatCgccctgcctgtcttctataa	8	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:99006196C>T	ENST00000393504.1	+	6	942	c.525C>T	c.(523-525)atC>atT	p.I175I	CNGA3_ENST00000409937.1_Silent_p.I179I|CNGA3_ENST00000436404.2_Silent_p.I157I|CNGA3_ENST00000272602.2_Silent_p.I175I	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	175					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						TGACCGCCATCGCCCTGCCTG	0.557													48	84					0	0	1	0	0	T	99006196	C	T	99006196	2	4	48	1	0	0	0	0	0	0	0	1	3621	874	31	1		1	CNGA3	2	99006196	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	77860	99006196	144193177	564	4958										
UNC50	25972	broad.mit.edu	37	chr2	99227280	99227280	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgctggacatgggattctTtgagacaataaagcttctcc	10	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:99227280T>C	ENST00000409975.1	+	2	1504	c.374T>C	c.(373-375)tTt>tCt	p.F125S	UNC50_ENST00000357765.2_Missense_Mutation_p.F108S|UNC50_ENST00000409347.1_Missense_Mutation_p.F125S			Q53HI1	UNC50_HUMAN	unc-50 homolog (C. elegans)	108					protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding			breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)	10						ATGGGATTCTTTGAGACAATA	0.398													4	143					0	0	1	0	0	C	99227280	T	C	99227280	3	2	48	1	0	0	0	0	1	0	0	0	17049	1841	64	4	329	4	UNC50	2	99227280	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	221084	99227280	143972093	565	4959										
MGAT4A	11320	broad.mit.edu	37	chr2	99294911	99294911	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctttcaaagcaaggaattCtcgttgataagcaatcagtt	7	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:99294911C>A	ENST00000393487.1	-	3	431	c.118G>T	c.(118-120)Gaa>Taa	p.E40*	MGAT4A_ENST00000264968.2_Nonsense_Mutation_p.E40*|MGAT4A_ENST00000409391.1_Nonsense_Mutation_p.E40*	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	40					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						GCAAGGAATTCTCGTTGATAA	0.338													15	24					1.05317e-09	1.27574e-09	1	1	0	A	99294911	C	A	99294911	4	1	48	1	0	0	0	0	0	1	0	0	9594	922	32	2	1647	2	MGAT4A	2	99294911	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67631	99294911	143904462	566	4960										
TXNDC9	10190	broad.mit.edu	37	chr2	99944079	99944079	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagtctctttcactagggAtttctctgtattccccatgt	6	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:99944079A>G	ENST00000264255.3	-	3	482	c.227T>C	c.(226-228)aTc>aCc	p.I76T	TXNDC9_ENST00000409434.1_Missense_Mutation_p.I76T	NM_005783.3	NP_005774.2	O14530	TXND9_HUMAN	thioredoxin domain containing 9	76	Thioredoxin.				cell redox homeostasis		protein binding			lung(1)	1						TTCACTAGGGATTTCTCTGTA	0.388													12	27					0	0	1	0	0	G	99944079	A	G	99944079	3	3	48	1	0	0	0	0	1	0	0	0	16863	333	12	4	465	4	TXNDC9	2	99944079	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	649168	99944079	143255294	567	4961										
REV1	51455	broad.mit.edu	37	chr2	100019523	100019523	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttcttcttgtttcttttCttttctttcactgctgcctt	3	10	6	0	rs1046340		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:100019523C>A	ENST00000258428.3	-	20	3441	c.3213G>T	c.(3211-3213)aaG>aaT	p.K1071N	REV1_ENST00000393445.3_Missense_Mutation_p.K1070N|REV1_ENST00000465835.1_5'UTR	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	1071					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						tgtttcttttcttttctttCA	0.383								Direct reversal of damage					10	22					0.335167	0.336004	1	1	0	A	100019523	C	A	100019523	3	1	48	1	0	0	0	0	1	0	0	0	13290	912	32	2	558	2	REV1	2	100019523	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	75444	100019523	143179850	568	4962										
AFF3	3899	broad.mit.edu	37	chr2	100194797	100194797	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctgaacttacatatcatcGaagacaagtttctgcctctt	6	10	4	2	rs142157056	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:100194797G>A	ENST00000317233.4	-	17	3145	c.2910C>T	c.(2908-2910)ttC>ttT	p.F970F	AFF3_ENST00000409236.1_Silent_p.F970F|AFF3_ENST00000409579.1_Silent_p.F995F|AFF3_ENST00000356421.2_Silent_p.F995F	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	970					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						ACATATCATCGAAGACAAGTT	0.542													65	126					0	0	1	0	0	A	100194797	G	A	100194797	2	1	48	1	0	0	0	0	0	0	0	1	357	1049	37	1		1	AFF3	2	100194797	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	175274	100194797	143004576	569	4963										
AFF3	3899	broad.mit.edu	37	chr2	100199424	100199424	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggggtgagatgggcgaccGaagcattttttcatttttat	13	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:100199424G>A	ENST00000317233.4	-	16	2864	c.2629C>T	c.(2629-2631)Cgg>Tgg	p.R877W	AFF3_ENST00000409236.1_Missense_Mutation_p.R877W|AFF3_ENST00000409579.1_Missense_Mutation_p.R902W|AFF3_ENST00000356421.2_Missense_Mutation_p.R902W	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	877					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						ATGGGCGACCGAAGCATTTTT	0.403													22	37					0	0	1	0	0	A	100199424	G	A	100199424	3	1	48	1	0	0	0	0	1	0	0	0	357	1057	37	1	1087	1	AFF3	2	100199424	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4627	100199424	142999949	570	4964										
AFF3	3899	broad.mit.edu	37	chr2	100210589	100210589	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggctgggctggcaaacgtCggggactttcccacagtcct	13	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:100210589C>T	ENST00000317233.4	-	14	1769	c.1534G>A	c.(1534-1536)Gac>Aac	p.D512N	AFF3_ENST00000409236.1_Missense_Mutation_p.D512N|AFF3_ENST00000409579.1_Missense_Mutation_p.D537N|AFF3_ENST00000356421.2_Missense_Mutation_p.D537N	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	512					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGGCAAACGTCGGGGACTTTC	0.547													61	120					0	0	1	0	0	T	100210589	C	T	100210589	3	4	48	1	0	0	0	0	1	0	0	0	357	884	31	1	2190	1	AFF3	2	100210589	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11165	100210589	142988784	571	4965										
LONRF2	164832	broad.mit.edu	37	chr2	100917219	100917219	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaattttcatgcacatttgCtgtagctgaaaacagcactt	6	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:100917219C>T	ENST00000393437.3	-	4	1591	c.952G>A	c.(952-954)Gca>Aca	p.A318T	LONRF2_ENST00000409647.1_Missense_Mutation_p.A75T	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2	318					proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						TGCACATTTGCTGTAGCTGAA	0.353													11	23					0	0	1	0	0	T	100917219	C	T	100917219	3	4	48	1	0	0	0	0	1	0	0	0	8939	797	28	3	1348	3	LONRF2	2	100917219	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	706630	100917219	142282154	572	4966										
CHST10	9486	broad.mit.edu	37	chr2	101010188	101010188	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaatttatccttaaatgcaGaaataagtctttcgaaggga	7	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:101010188G>A	ENST00000264249.3	-	7	975	c.590C>T	c.(589-591)tCt>tTt	p.S197F	CHST10_ENST00000542617.1_Missense_Mutation_p.S245F|CHST10_ENST00000409701.1_Missense_Mutation_p.S197F	NM_004854.4	NP_004845.1	O43529	CHSTA_HUMAN	carbohydrate sulfotransferase 10	197					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						CTTAAATGCAGAAATAAGTCT	0.393													30	57					0	0	1	0	0	A	101010188	G	A	101010188	3	1	48	1	0	0	0	0	1	0	0	0	3420	942	33	3	484	3	CHST10	2	101010188	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	92969	101010188	142189185	573	4967										
IL1R2	7850	broad.mit.edu	37	chr2	102626170	102626170	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaacctgacatggcataaaAatgactctgctaggacggtc	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:102626170A>C	ENST00000332549.3	+	3	443	c.214A>C	c.(214-216)Aat>Cat	p.N72H	IL1R2_ENST00000393414.2_Missense_Mutation_p.N72H|IL1R2_ENST00000441002.1_Missense_Mutation_p.N72H	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	72	Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	ATGGCATAAAAATGACTCTGC	0.612													90	147					0	0	1	0	0	C	102626170	A	C	102626170	3	2	48	1	0	0	0	0	1	0	0	0	7702	14	1	4	220	4	IL1R2	2	102626170	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1615982	102626170	140573203	574	4968										
SLC9A4	389015	broad.mit.edu	37	chr2	103121726	103121726	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatagaatcacagcctgcGcagtaacaatgaaaaagtac	7	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:103121726G>A	ENST00000295269.4	+	4	1451	c.994G>A	c.(994-996)Gca>Aca	p.A332T		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	332					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CACAGCCTGCGCAGTAACAAT	0.483													9	22					0	0	1	0	0	A	103121726	G	A	103121726	3	1	48	1	0	0	0	0	1	0	0	0	14770	1087	38	1	1008	1	SLC9A4	2	103121726	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	495556	103121726	140077647	575	4969										
SLC9A4	389015	broad.mit.edu	37	chr2	103141567	103141567	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatccgccgccagaacaccTtaagggagagcatgaggaaa	12	10	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:103141567T>G	ENST00000295269.4	+	10	2360	c.1903T>G	c.(1903-1905)Tta>Gta	p.L635V		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	635					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CCAGAACACCTTAAGGGAGAG	0.512													83	116					0	0	1	0	0	G	103141567	T	G	103141567	3	3	48	1	0	0	0	0	1	0	0	0	14770	1606	56	4	1941	4	SLC9A4	2	103141567	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	19841	103141567	140057806	576	4970										
FHL2	2274	broad.mit.edu	37	chr2	106002940	106002940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcttgccaaagagagattCgttgcaatggtggcagtcaa	11	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:106002940C>T	ENST00000409177.1	-	2	503	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	FHL2_ENST00000393353.3_Missense_Mutation_p.E12K|FHL2_ENST00000393352.3_Missense_Mutation_p.E12K|FHL2_ENST00000322142.8_Missense_Mutation_p.E12K|FHL2_ENST00000344213.4_Missense_Mutation_p.E122K|FHL2_ENST00000607522.1_Missense_Mutation_p.E12K|FHL2_ENST00000358129.4_Missense_Mutation_p.E12K|FHL2_ENST00000336660.5_Missense_Mutation_p.E12K|FHL2_ENST00000408995.1_Missense_Mutation_p.E12K|FHL2_ENST00000409807.1_Missense_Mutation_p.E12K			Q14192	FHL2_HUMAN	four and a half LIM domains 2	12	LIM zinc-binding 2.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9						AAGAGAGATTCGTTGCAATGG	0.498													25	64					0	0	1	0	0	T	106002940	C	T	106002940	3	4	48	1	0	0	0	0	1	0	0	0	5911	893	31	1	825	1	FHL2	2	106002940	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2861373	106002940	137196433	577	4971										
UXS1	80146	broad.mit.edu	37	chr2	106713223	106713223	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttttgatgtctggttttCttttctgtgggtcatcctgg	10	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:106713223C>A	ENST00000283148.7	-	14	1194	c.1097G>T	c.(1096-1098)aGa>aTa	p.R366I	UXS1_ENST00000540130.1_Missense_Mutation_p.R304I|UXS1_ENST00000409501.3_Missense_Mutation_p.R361I|UXS1_ENST00000409032.1_Missense_Mutation_p.R193I	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	361					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						GTCTGGTTTTCTTTTCTGTGG	0.488													3	6					0.004672	0.00483628	1	1	0	A	106713223	C	A	106713223	3	1	48	1	0	0	0	0	1	0	0	0	17168	913	32	2	188	2	UXS1	2	106713223	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	710283	106713223	136486150	578	4972										
SLC5A7	60482	broad.mit.edu	37	chr2	108614432	108614432	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgttcagctcttttgcatttTtgtagggctggtaagtggga	13	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:108614432T>G	ENST00000264047.2	+	5	863	c.587T>G	c.(586-588)tTt>tGt	p.F196C	SLC5A7_ENST00000409059.1_Missense_Mutation_p.F196C|SLC5A7_ENST00000540517.1_Missense_Mutation_p.F91C	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	196					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	TTTTGCATTTTTGTAGGGCTG	0.398													27	52					0	0	1	0	0	G	108614432	T	G	108614432	3	3	48	1	0	0	0	0	1	0	0	0	14724	1841	64	4	601	4	SLC5A7	2	108614432	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1901209	108614432	134584941	579	4973										
SULT1C2	6819	broad.mit.edu	37	chr2	108921632	108921632	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtgtctatttcagtggtTtggggttcctggtttgacca	12	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:108921632T>G	ENST00000326853.5	+	7	993	c.540T>G	c.(538-540)gtT>gtG	p.V180V	SULT1C2_ENST00000437390.2_Silent_p.V183V|SULT1C2_ENST00000409880.1_Silent_p.V132V|SULT1C2_ENST00000251481.6_Silent_p.V169V	NM_176825.2	NP_789795.1	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 2	169					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20						TTTCAGTGGTTTGGGGTTCCT	0.428													43	65					0	0	1	0	0	G	108921632	T	G	108921632	2	3	48	1	0	0	0	0	0	0	0	1	15432	1828	64	4		4	SULT1C2	2	108921632	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	307200	108921632	134277741	580	4974										
GCC2	9648	broad.mit.edu	37	chr2	109086776	109086776	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttgtagaacaagtagtaAatgaaaaagtcaaacactta	6	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:109086776A>C	ENST00000309863.6	+	6	1705	c.991A>C	c.(991-993)Aat>Cat	p.N331H		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	331					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ACAAGTAGTAAATGAAAAAGT	0.289													19	40					0	0	1	0	0	C	109086776	A	C	109086776	3	2	48	1	0	0	0	0	1	0	0	0	6325	14	1	4	1013	4	GCC2	2	109086776	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	165144	109086776	134112597	581	4975										
GCC2	9648	broad.mit.edu	37	chr2	109098819	109098819	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctaatgccaaattattagAagtacagattttagaagtcc	7	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:109098819A>G	ENST00000309863.6	+	11	3971	c.3257A>G	c.(3256-3258)gAa>gGa	p.E1086G		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1086					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AAATTATTAGAAGTACAGATT	0.328													17	28					0	0	1	0	0	G	109098819	A	G	109098819	3	3	48	1	0	0	0	0	1	0	0	0	6325	246	9	4	3299	4	GCC2	2	109098819	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	12043	109098819	134100554	582	4976										
RANBP2	5903	broad.mit.edu	37	chr2	109381241	109381241	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattggtgactccaaagaaaGaaggtcactgggattgtagt	12	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:109381241G>A	ENST00000283195.6	+	20	4372	c.4246G>A	c.(4246-4248)Gaa>Aaa	p.E1416K		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	1416					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TCCAAAGAAAGAAGGTCACTG	0.398													26	59					0	0	1	0	0	A	109381241	G	A	109381241	3	1	48	1	0	0	0	0	1	0	0	0	13079	943	33	3	4324	3	RANBP2	2	109381241	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	282422	109381241	133818132	583	4977										
EDAR	10913	broad.mit.edu	37	chr2	109513452	109513452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggactccacagcatccagccGctcaatctgcaccagttttg	8	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:109513452G>A	ENST00000409271.1	-	12	1797	c.1354C>T	c.(1354-1356)Cgg>Tgg	p.R452W	EDAR_ENST00000376651.1_Missense_Mutation_p.R452W|EDAR_ENST00000258443.2_Missense_Mutation_p.R420W			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	420					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						GCATCCAGCCGCTCAATCTGC	0.572													8	14					0	0	1	0	0	A	109513452	G	A	109513452	3	1	48	1	0	0	0	0	1	0	0	0	4931	1086	38	1	92	1	EDAR	2	109513452	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	132211	109513452	133685921	584	4978										
NPHP1	4867	broad.mit.edu	37	chr2	110881402	110881402	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctcatttcacccaagaagTcataggtctgctctgaaagg	8	10	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:110881402T>C	ENST00000316534.4	-	20	2241	c.2168A>G	c.(2167-2169)gAc>gGc	p.D723G	NPHP1_ENST00000417665.1_Missense_Mutation_p.D701G|NPHP1_ENST00000393272.3_Missense_Mutation_p.D722G|NPHP1_ENST00000445609.2_Missense_Mutation_p.D667G|NPHP1_ENST00000355301.4_Missense_Mutation_p.D604G			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	722					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						ACCCAAGAAGTCATAGGTCTG	0.493													13	59					0	0	1	0	0	C	110881402	T	C	110881402	3	2	48	1	0	0	0	0	1	0	0	0	10625	1667	58	4	37	4	NPHP1	2	110881402	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1367950	110881402	132317971	585	4979										
ANAPC1	64682	broad.mit.edu	37	chr2	112621315	112621315	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactgggtgatgaggttgagCgactctggctgtgaatggag	18	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:112621315C>T	ENST00000341068.3	-	9	1761	c.989G>A	c.(988-990)cGc>cAc	p.R330H		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	330					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						TGAGGTTGAGCGACTCTGGCT	0.473													26	45					0	0	1	0	0	T	112621315	C	T	112621315	3	4	48	1	0	0	0	0	1	0	0	0	594	768	27	1	5005	1	ANAPC1	2	112621315	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1739913	112621315	130578058	586	4980										
MERTK	10461	broad.mit.edu	37	chr2	112779123	112779123	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggatcgccatagaaagtCttgcagaccgagtctacaca	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:112779123C>A	ENST00000295408.4	+	17	2571	c.2314C>A	c.(2314-2316)Ctt>Att	p.L772I	MERTK_ENST00000421804.2_Missense_Mutation_p.L772I|MERTK_ENST00000409780.1_Missense_Mutation_p.L596I			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	772	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CATAGAAAGTCTTGCAGACCG	0.458													18	70					5.35267e-07	6.09026e-07	1	1	0	A	112779123	C	A	112779123	3	1	48	1	0	0	0	0	1	0	0	0	9528	913	32	2	2380	2	MERTK	2	112779123	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	157808	112779123	130420250	587	4981										
ZC3H8	84524	broad.mit.edu	37	chr2	112991726	112991726	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcctttcaagaaaatattTacaaatttgttttcccttgc	3	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:112991726T>G	ENST00000409573.1	-	5	721	c.592A>C	c.(592-594)Aaa>Caa	p.K198Q	ZC3H8_ENST00000272570.5_Missense_Mutation_p.K198Q			Q8N5P1	ZC3H8_HUMAN	zinc finger CCCH-type containing 8	198					apoptosis|negative regulation of T cell differentiation in thymus|negative regulation of transcription, DNA-dependent|positive regulation of thymocyte apoptosis|response to antibiotic|T cell homeostasis	nucleus	RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	7						AGAAAATATTTACAAATTTGT	0.308													6	6					0	0	1	0	0	G	112991726	T	G	112991726	3	3	48	1	0	0	0	0	1	0	0	0	17632	1763	61	4	299	4	ZC3H8	2	112991726	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	212603	112991726	130207647	588	4982										
ZC3H6	376940	broad.mit.edu	37	chr2	113079393	113079393	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaccagggagacaactgtaAattttcccatgatgatctaa	7	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:113079393A>C	ENST00000409871.1	+	8	1438	c.1037A>C	c.(1036-1038)aAa>aCa	p.K346T	ZC3H6_ENST00000343936.4_Missense_Mutation_p.K346T	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	346							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						GACAACTGTAAATTTTCCCAT	0.308													5	7					0	0	1	0	0	C	113079393	A	C	113079393	3	2	48	1	0	0	0	0	1	0	0	0	17629	14	1	4	1067	4	ZC3H6	2	113079393	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	87667	113079393	130119980	589	4983										
ZC3H6	376940	broad.mit.edu	37	chr2	113082687	113082687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctccctgcagtgcaaagaGctctttttgtaagacttact	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:113082687G>A	ENST00000409871.1	+	11	2400	c.1999G>A	c.(1999-2001)Gct>Act	p.A667T	ZC3H6_ENST00000343936.4_Missense_Mutation_p.A667T	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	667							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						AGTGCAAAGAGCTCTTTTTGT	0.517													16	37					0	0	1	0	0	A	113082687	G	A	113082687	3	1	48	1	0	0	0	0	1	0	0	0	17629	971	34	3	2041	3	ZC3H6	2	113082687	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3294	113082687	130116686	590	4984										
POLR1B	84172	broad.mit.edu	37	chr2	113308539	113308539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgttgaactttatttaccGaaaagaactgttctttcttc	5	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:113308539G>A	ENST00000263331.5	+	5	1302	c.722G>A	c.(721-723)cGa>cAa	p.R241Q	POLR1B_ENST00000417433.2_Missense_Mutation_p.R185Q|POLR1B_ENST00000409894.3_Missense_Mutation_p.R241Q|POLR1B_ENST00000541869.1_Missense_Mutation_p.R279Q|POLR1B_ENST00000537335.1_Missense_Mutation_p.R30Q	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	241					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						TTTATTTACCGAAAAGAACTG	0.378													20	82					0	0	1	0	0	A	113308539	G	A	113308539	3	1	48	1	0	0	0	0	1	0	0	0	12257	1058	37	1	740	1	POLR1B	2	113308539	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	225852	113308539	129890834	591	4985										
IL1A	3552	broad.mit.edu	37	chr2	113537171	113537171	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattcaggatgaattcgtatTtgatgatcctcataaagttg	8	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:113537171T>G	ENST00000263339.3	-	5	547	c.392A>C	c.(391-393)aAa>aCa	p.K131T		NM_000575.3	NP_000566.3	P01583	IL1A_HUMAN	interleukin 1, alpha	131					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			breast(2)|large_intestine(1)|lung(9)	12						GAATTCGTATTTGATGATCCT	0.403													14	24					0	0	1	0	0	G	113537171	T	G	113537171	3	3	48	1	0	0	0	0	1	0	0	0	7693	1841	64	4	435	4	IL1A	2	113537171	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	228632	113537171	129662202	592	4986										
IL1B	3553	broad.mit.edu	37	chr2	113590973	113590973	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcaaagatgaagggaaaGaaggtgctcaggtcattctc	11	7	5	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:113590973G>T	ENST00000263341.2	-	4	489	c.279C>A	c.(277-279)ttC>ttA	p.F93L	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	93					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	TGAAGGGAAAGAAGGTGCTCA	0.532													36	51					2.09667e-21	2.89385e-21	1	1	0	T	113590973	G	T	113590973	3	4	48	1	0	0	0	0	1	0	0	0	7694	933	33	2	546	2	IL1B	2	113590973	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53802	113590973	129608400	593	4987										
PSD4	23550	broad.mit.edu	37	chr2	113940100	113940100	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctcaacctgtacttgggaGacagcctggagccccaccca	9	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:113940100G>A	ENST00000245796.6	+	2	262	c.67G>A	c.(67-69)Gac>Aac	p.D23N	PSD4_ENST00000441564.2_Missense_Mutation_p.D23N|PSD4_ENST00000465917.1_3'UTR	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	23					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GTACTTGGGAGACAGCCTGGA	0.607													22	52					0	0	1	0	0	A	113940100	G	A	113940100	3	1	48	1	0	0	0	0	1	0	0	0	12697	942	33	3	69	3	PSD4	2	113940100	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	349127	113940100	129259273	594	4988										
DPP10	57628	broad.mit.edu	37	chr2	116548868	116548868	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctttctttaaaagaacttCctttacagttgtcccttccc	3	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:116548868C>A	ENST00000410059.1	+	19	2116	c.1636C>A	c.(1636-1638)Cct>Act	p.P546T	DPP10_ENST00000310323.8_Missense_Mutation_p.P539T|DPP10_ENST00000393147.2_Missense_Mutation_p.P550T|DPP10_ENST00000409163.1_Missense_Mutation_p.P496T	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	546					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AAAAGAACTTCCTTTACAGTT	0.313													11	31					3.27435e-08	3.83577e-08	1	1	0	A	116548868	C	A	116548868	3	1	48	1	0	0	0	0	1	0	0	0	4753	855	30	2	1881	2	DPP10	2	116548868	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2608768	116548868	126650505	595	4989										
DPP10	57628	broad.mit.edu	37	chr2	116598356	116598356	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccaacactcagcagaatTaatcaagcacctaataaaag	4	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:116598356T>G	ENST00000410059.1	+	25	2693	c.2213T>G	c.(2212-2214)tTa>tGa	p.L738*	DPP10_ENST00000310323.8_Nonsense_Mutation_p.L731*|DPP10_ENST00000393147.2_Nonsense_Mutation_p.L742*|DPP10_ENST00000409163.1_Nonsense_Mutation_p.L688*	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	738					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TCAGCAGAATTAATCAAGCAC	0.328													7	35					0	0	1	0	0	G	116598356	T	G	116598356	4	3	48	1	0	0	0	0	0	1	0	0	4753	1764	61	4	2482	4	DPP10	2	116598356	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	49488	116598356	126601017	596	4990										
CCDC93	54520	broad.mit.edu	37	chr2	118705682	118705682	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaccaaacaacacttactCgacaatgtgctttaaattcc	4	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:118705682C>T	ENST00000376300.2	-	15	1360	c.1224_splice	c.e15+1	p.R408_splice	CCDC93_ENST00000319432.5_Splice_Site_p.R407_splice	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	408								p.R408L(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						AACACTTACTCGACAATGTGC	0.398													70	124					0	0	1	0	0	T	118705682	C	T	118705682	5	4	48	1	0	0	0	0	0	0	1	0	2892	898	31	1	712	1	CCDC93	2	118705682	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2107326	118705682	124493691	597	4991										
CCDC93	54520	broad.mit.edu	37	chr2	118731517	118731517	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcggacacaatctgcttgatCtcagcagagcagagtcccac	9	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:118731517C>A	ENST00000376300.2	-	11	992	c.855G>T	c.(853-855)gaG>gaT	p.E285D	CCDC93_ENST00000319432.5_Missense_Mutation_p.E284D|CCDC93_ENST00000460781.1_5'UTR	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	285										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						TCTGCTTGATCTCAGCAGAGC	0.552													8	11					2.17888e-05	2.39107e-05	1	1	0	A	118731517	C	A	118731517	3	1	48	1	0	0	0	0	1	0	0	0	2892	912	32	2	1096	2	CCDC93	2	118731517	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	25835	118731517	124467856	598	4992										
INSIG2	51141	broad.mit.edu	37	chr2	118864481	118864481	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatataatggtgtttaccagTaagtattaatccttcaattt	5	5	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:118864481T>C	ENST00000245787.4	+	4	742		c.e4+2		INSIG2_ENST00000485520.1_Splice_Site	NM_016133.2	NP_057217.2	Q9Y5U4	INSI2_HUMAN	insulin induced gene 2						ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						TGTTTACCAGTAAGTATTAAT	0.358													9	88					0	0	1	0	0	C	118864481	T	C	118864481	5	2	48	1	0	0	0	0	0	0	1	0	7809	1652	57	4	548	4	INSIG2	2	118864481	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	132964	118864481	124334892	599	4993										
RALB	5899	broad.mit.edu	37	chr2	121043504	121043504	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttatagaaagaaagtggttCttgatggggaagaagttcag	14	2	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:121043504C>A	ENST00000272519.5	+	3	439	c.169C>A	c.(169-171)Ctt>Att	p.L57I	RALB_ENST00000420510.1_Missense_Mutation_p.L57I|RALB_ENST00000474855.2_Missense_Mutation_p.L79I|RALB_ENST00000404963.3_Missense_Mutation_p.L78I|RALB_ENST00000470417.1_Intron	NM_002881.2	NP_002872.1	P11234	RALB_HUMAN	v-ral simian leukemia viral oncogene homolog B	57					apoptosis|cell cycle|cytokinesis|nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of exocyst assembly|regulation of exocyst localization	cytosol|midbody|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(154;0.122)				GAAAGTGGTTCTTGATGGGGA	0.418													17	40					1.33834e-09	1.61283e-09	1	1	0	A	121043504	C	A	121043504	3	1	48	1	0	0	0	0	1	0	0	0	13062	913	32	2	175	2	RALB	2	121043504	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2179023	121043504	122155869	600	4994										
RALB	5899	broad.mit.edu	37	chr2	121043521	121043521	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcttgatggggaagaagtTcagatagatattctggacac	12	5	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:121043521T>G	ENST00000272519.5	+	3	456	c.186T>G	c.(184-186)gtT>gtG	p.V62V	RALB_ENST00000420510.1_Silent_p.V62V|RALB_ENST00000474855.2_Silent_p.V84V|RALB_ENST00000404963.3_Silent_p.V83V|RALB_ENST00000470417.1_Intron	NM_002881.2	NP_002872.1	P11234	RALB_HUMAN	v-ral simian leukemia viral oncogene homolog B	62					apoptosis|cell cycle|cytokinesis|nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of exocyst assembly|regulation of exocyst localization	cytosol|midbody|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(154;0.122)				GGGAAGAAGTTCAGATAGATA	0.413													14	38					0	0	1	0	0	G	121043521	T	G	121043521	2	3	48	1	0	0	0	0	0	0	0	1	13062	1770	62	4		4	RALB	2	121043521	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	17	121043521	122155852	601	4995										
GLI2	2736	broad.mit.edu	37	chr2	121736119	121736119	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagtacatgctggtggtgcAcatgcggcgacacacgggcg	16	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:121736119A>G	ENST00000452319.1	+	10	1538	c.1478A>G	c.(1477-1479)cAc>cGc	p.H493R	GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.H493R|GLI2_ENST00000314490.11_Missense_Mutation_p.H165R			P10070	GLI2_HUMAN	GLI family zinc finger 2	493					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CTGGTGGTGCACATGCGGCGA	0.652													17	125					0	0	1	0	0	G	121736119	A	G	121736119	3	3	48	1	0	0	0	0	1	0	0	0	6479	159	6	4	1512	4	GLI2	2	121736119	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	692598	121736119	121463254	602	4996										
GLI2	2736	broad.mit.edu	37	chr2	121745903	121745903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctgagccagctgcaggagCgccgcgacagctccaccagc	13	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:121745903C>T	ENST00000452319.1	+	14	2473	c.2413C>T	c.(2413-2415)Cgc>Tgc	p.R805C	GLI2_ENST00000361492.4_Missense_Mutation_p.R805C|GLI2_ENST00000314490.11_Missense_Mutation_p.R477C			P10070	GLI2_HUMAN	GLI family zinc finger 2	805	Ser-rich.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GCTGCAGGAGCGCCGCGACAG	0.736													7	10					0	0	1	0	0	T	121745903	C	T	121745903	3	4	48	1	0	0	0	0	1	0	0	0	6479	768	27	1	2463	1	GLI2	2	121745903	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9784	121745903	121453470	603	4997										
CLASP1	23332	broad.mit.edu	37	chr2	122120867	122120867	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactcttaacgccagtgctcGaattgaatgctagaatacaa	7	9	1	2	rs145127425	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:122120867G>A	ENST00000263710.4	-	37	4476	c.4087C>T	c.(4087-4089)Cga>Tga	p.R1363*	CLASP1_ENST00000409078.3_Nonsense_Mutation_p.R1296*|CLASP1_ENST00000541859.1_Nonsense_Mutation_p.R1080*|CLASP1_ENST00000397587.3_Nonsense_Mutation_p.R1303*|CLASP1_ENST00000455322.2_Nonsense_Mutation_p.R1319*|CLASP1_ENST00000545861.1_Nonsense_Mutation_p.R1070*|CLASP1_ENST00000541377.1_Nonsense_Mutation_p.R1302*	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1363	Interaction with CLIP2 (By similarity).|Interaction with PHLDB2 and RSN.|Localization to kinetochores.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding	p.R1363*(2)		NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					GCCAGTGCTCGAATTGAATGC	0.468													8	27					0	0	1	0	0	A	122120867	G	A	122120867	4	1	48	1	0	0	0	0	0	1	0	0	3477	1066	37	1	545	1	CLASP1	2	122120867	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	374964	122120867	121078506	604	4998										
MYO7B	4648	broad.mit.edu	37	chr2	128347738	128347738	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctggaccagctgatgaaAatcctgaccaactgccagcc	8	14	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:128347738A>C	ENST00000389524.4	+	16	1979	c.1926A>C	c.(1924-1926)aaA>aaC	p.K642N	MYO7B_ENST00000428314.1_Missense_Mutation_p.K642N|MYO7B_ENST00000409816.2_Missense_Mutation_p.K642N			Q6PIF6	MYO7B_HUMAN	myosin VIIB	642	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGCTGATGAAAATCCTGACCA	0.512													11	21					0	0	1	0	0	C	128347738	A	C	128347738	3	2	48	1	0	0	0	0	1	0	0	0	10130	11	1	4	1984	4	MYO7B	2	128347738	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6226871	128347738	114851635	605	4999										
SAP130	79595	broad.mit.edu	37	chr2	128783864	128783864	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaggaaactgttgagaactCatttccacctgtagtacata	8	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:128783864C>A	ENST00000357702.5	-	2	212	c.81G>T	c.(79-81)atG>atT	p.M27I	SAP130_ENST00000259234.6_Start_Codon_SNP_p.M1I|SAP130_ENST00000259235.3_Missense_Mutation_p.M27I	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	27					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		GTTGAGAACTCATTTCCACCT	0.423													20	48					4.35082e-09	5.20082e-09	1	1	0	A	128783864	C	A	128783864	3	1	48	1	0	0	0	0	1	0	0	0	13882	826	29	2	3250	2	SAP130	2	128783864	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	436126	128783864	114415509	606	5000										
TUBA3E	112714	broad.mit.edu	37	chr2	130951526	130951526	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccatctgattggctggctCgaagcaggcattggtgatct	13	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:130951526C>T	ENST00000312988.7	-	4	989	c.889G>A	c.(889-891)Gag>Aag	p.E297K		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	297					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					TTGGCTGGCTCGAAGCAGGCA	0.597													75	131					0	0	1	0	0	T	130951526	C	T	130951526	3	4	48	1	0	0	0	0	1	0	0	0	16809	893	31	1	471	1	TUBA3E	2	130951526	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2167662	130951526	112247847	607	5001										
POTEE	445582	broad.mit.edu	37	chr2	132020932	132020932	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctttgtttacttagctttCtcttagttgtaagaaagaaa	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:132020932C>A	ENST00000356920.5	+	15	1998	c.1904C>A	c.(1903-1905)tCt>tAt	p.S635Y	PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	635							ATP binding										ACTTAGCTTTCTCTTAGTTGT	0.323													6	15					1.12685e-05	1.24509e-05	1	1	0	A	132020932	C	A	132020932	3	1	48	1	0	0	0	0	1	0	0	0	12310	913	32	2	1962	2	POTEE	2	132020932	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1069406	132020932	111178441	608	5002										
GPR39	2863	broad.mit.edu	37	chr2	133402871	133402871	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtgtcctcgcagcagtttCggcgggtgttcgtgcaggtg	17	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:133402871C>T	ENST00000329321.3	+	2	1523	c.1054C>T	c.(1054-1056)Cgg>Tgg	p.R352W	GPR39_ENST00000470071.1_3'UTR|LYPD1_ENST00000397463.2_3'UTR	NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	352						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GCAGCAGTTTCGGCGGGTGTT	0.632													21	48					0	0	1	0	0	T	133402871	C	T	133402871	3	4	48	1	0	0	0	0	1	0	0	0	6732	875	31	1	1060	1	GPR39	2	133402871	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1381939	133402871	109796502	609	5003										
NCKAP5	344148	broad.mit.edu	37	chr2	133547778	133547778	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgtatttagttggtgttCctgaaaaagcaggacagctc	10	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:133547778C>T	ENST00000409261.1	-	13	1283	c.909_splice	c.e13-1	p.E304_splice	NCKAP5_ENST00000317721.6_Splice_Site_p.E304_splice|NCKAP5_ENST00000409213.1_Splice_Site_p.E304_splice|NCKAP5_ENST00000405974.3_Splice_Site_p.E304_splice	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	304							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AGTTGGTGTTCCTGAAAAAGC	0.483													4	16					0	0	1	0	0	T	133547778	C	T	133547778	5	4	48	1	0	0	0	0	0	0	1	0	10269	869	30	3	4851	3	NCKAP5	2	133547778	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	144907	133547778	109651595	610	5004										
MGAT5	4249	broad.mit.edu	37	chr2	135099273	135099273	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggagtgatttaattacatCtctgtacttactgggccatg	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:135099273C>A	ENST00000409645.1	+	8	1172	c.920C>A	c.(919-921)tCt>tAt	p.S307Y	MGAT5_ENST00000281923.2_Missense_Mutation_p.S307Y			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	307					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		TTAATTACATCTCTGTACTTA	0.398													6	35					8.12818e-05	8.79784e-05	1	1	0	A	135099273	C	A	135099273	3	1	48	1	0	0	0	0	1	0	0	0	9597	913	32	2	946	2	MGAT5	2	135099273	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1551495	135099273	108100100	611	5005										
ZRANB3	84083	broad.mit.edu	37	chr2	135965024	135965024	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttctaatgggagctttgAagtccaggtagcatacagaa	11	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:135965024A>G	ENST00000401392.1	-	19	3195	c.2983T>C	c.(2983-2985)Tca>Cca	p.S995P	ZRANB3_ENST00000536680.1_Missense_Mutation_p.S995P|ZRANB3_ENST00000412849.1_5'UTR|ZRANB3_ENST00000264159.6_Missense_Mutation_p.S997P			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	997						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		GGGAGCTTTGAAGTCCAGGTA	0.378													13	123					0	0	1	0	0	G	135965024	A	G	135965024	3	3	48	1	0	0	0	0	1	0	0	0	18265	246	9	4	262	4	ZRANB3	2	135965024	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	865751	135965024	107234349	612	5006										
ZRANB3	84083	broad.mit.edu	37	chr2	135988495	135988495	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatgctgtttttctttttcGaactaggaaaagcaaacagt	7	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:135988495G>A	ENST00000401392.1	-	13	1754	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F	ZRANB3_ENST00000536680.1_Silent_p.F514F|ZRANB3_ENST00000412849.1_5'UTR|ZRANB3_ENST00000264159.6_Silent_p.F514F			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	514						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		TTTCTTTTTCGAACTAGGAAA	0.323													9	8					0	0	1	0	0	A	135988495	G	A	135988495	2	1	48	1	0	0	0	0	0	0	0	1	18265	1049	37	1		1	ZRANB3	2	135988495	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23471	135988495	107210878	613	5007										
MCM6	4175	broad.mit.edu	37	chr2	136598517	136598517	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtgagctcaattagaacaTgatcctgtgaaacacaaata	9	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:136598517T>C	ENST00000264156.2	-	17	2414	c.2354A>G	c.(2353-2355)cAt>cGt	p.H785R		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	785					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	AATTAGAACATGATCCTGTGA	0.423													21	28					0	0	1	0	0	C	136598517	T	C	136598517	3	2	48	1	0	0	0	0	1	0	0	0	9440	1464	51	4	115	4	MCM6	2	136598517	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	610022	136598517	106600856	614	5008										
DARS	1615	broad.mit.edu	37	chr2	136673886	136673886	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcttagagttggctccaaaAatttgaatggctcacatggg	11	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:136673886A>C	ENST00000264161.4	-	11	1231	c.1016T>G	c.(1015-1017)tTt>tGt	p.F339C	DARS_ENST00000537273.1_Missense_Mutation_p.F239C	NM_001349.2	NP_001340.2	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	339					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(2)	15				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	TGGCTCCAAAAATTTGAATGG	0.363													6	67					0	0	1	0	0	C	136673886	A	C	136673886	3	2	48	1	0	0	0	0	1	0	0	0	4265	14	1	4	513	4	DARS	2	136673886	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	75369	136673886	106525487	615	5009										
LRP1B	53353	broad.mit.edu	37	chr2	141081612	141081612	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatataatcttcaaagatatCgatcctatgtggatgtaata	6	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:141081612C>T	ENST00000389484.3	-	81	13335	c.12364G>A	c.(12364-12366)Gat>Aat	p.D4122N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4122					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAAAGATATCGATCCTATGT	0.303										TSP Lung(27;0.18)			11	21					0	0	1	0	0	T	141081612	C	T	141081612	3	4	48	1	0	0	0	0	1	0	0	0	8999	884	31	1	1479	1	LRP1B	2	141081612	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4407726	141081612	102117761	616	5010										
LRP1B	53353	broad.mit.edu	37	chr2	141128753	141128753	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacaatatattttacctcatCtgaaccatcagcacaatcat	2	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:141128753C>A	ENST00000389484.3	-	70	11841	c.10870G>T	c.(10870-10872)Gat>Tat	p.D3624Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3624	LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		tttaCCTCATCTGAACCATCA	0.299										TSP Lung(27;0.18)			8	10					0.00448238	0.00465112	1	1	0	A	141128753	C	A	141128753	3	1	48	1	0	0	0	0	1	0	0	0	8999	913	32	2	3017	2	LRP1B	2	141128753	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47141	141128753	102070620	617	5011										
LRP1B	53353	broad.mit.edu	37	chr2	141298598	141298598	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctgcaggaacaattcactCtcccattgggagttaaaagg	9	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:141298598C>A	ENST00000389484.3	-	45	8428	c.7457G>T	c.(7456-7458)aGa>aTa	p.R2486I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2486					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAATTCACTCTCCCATTGGG	0.403										TSP Lung(27;0.18)			28	56					3.65163e-15	4.79858e-15	1	1	0	A	141298598	C	A	141298598	3	1	48	1	0	0	0	0	1	0	0	0	8999	913	32	2	6530	2	LRP1B	2	141298598	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	169845	141298598	101900775	618	5012										
LRP1B	53353	broad.mit.edu	37	chr2	141607716	141607716	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttccgttaataaaagctcGtttaatggtttgtgttttaa	8	4	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:141607716G>A	ENST00000389484.3	-	29	5865	c.4894C>T	c.(4894-4896)Cga>Tga	p.R1632*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1632					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATAAAAGCTCGTTTAATGGTT	0.338										TSP Lung(27;0.18)			26	42					0	0	1	0	0	A	141607716	G	A	141607716	4	1	48	1	0	0	0	0	0	1	0	0	8999	1153	40	1	9157	1	LRP1B	2	141607716	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	309118	141607716	101591657	619	5013										
LRP1B	53353	broad.mit.edu	37	chr2	141641477	141641477	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccatctagtttggccacttCgatttggtccagattgctgt	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:141641477C>T	ENST00000389484.3	-	25	5049	c.4078G>A	c.(4078-4080)Gaa>Aaa	p.E1360K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1360					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGCCACTTCGATTTGGTCC	0.498										TSP Lung(27;0.18)			35	56					0	0	1	0	0	T	141641477	C	T	141641477	3	4	48	1	0	0	0	0	1	0	0	0	8999	893	31	1	9989	1	LRP1B	2	141641477	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	33761	141641477	101557896	620	5014										
KYNU	8942	broad.mit.edu	37	chr2	143798010	143798010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccacagatctttaagcaagCgacaatgaaggcattgcgga	10	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:143798010C>T	ENST00000264170.4	+	13	1313	c.1055C>T	c.(1054-1056)gCg>gTg	p.A352V	KYNU_ENST00000409512.1_Missense_Mutation_p.A352V	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	352					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTAAGCAAGCGACAATGAAG	0.338													12	22					0	0	1	0	0	T	143798010	C	T	143798010	3	4	48	1	0	0	0	0	1	0	0	0	8625	768	27	1	1127	1	KYNU	2	143798010	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2156533	143798010	99401363	621	5015										
MBD5	0	broad.mit.edu	37	chr2	149220204	149220204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggttaaaacatacctgcttaCtgatggaacatgcaagtgtg	10	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:149220204C>T	ENST00000407073.1	+	7	1164	c.167C>T	c.(166-168)aCt>aTt	p.T56I	MBD5_ENST00000404807.1_Missense_Mutation_p.T56I	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	56	MBD.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TACCTGCTTACTGATGGAACA	0.353													12	41					0	0	1	0	0	T	149220204	C	T	149220204	3	4	48	1	0	0	0	0	1	0	0	0	9396	565	20	3	173	3	MBD5	2	149220204	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5422194	149220204	93979169	622	5016										
MBD5	0	broad.mit.edu	37	chr2	149226980	149226980	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagtggtattaaggttccaCccaggtcaccaaggtcaaca	9	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:149226980C>T	ENST00000407073.1	+	9	2465	c.1468C>T	c.(1468-1470)Ccc>Tcc	p.P490S	MBD5_ENST00000404807.1_Missense_Mutation_p.P490S	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	490						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TAAGGTTCCACCCAGGTCACC	0.493													11	67					0	0	1	0	0	T	149226980	C	T	149226980	3	4	48	1	0	0	0	0	1	0	0	0	9396	507	18	3	1482	3	MBD5	2	149226980	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6776	149226980	93972393	623	5017										
KIF5C	3800	broad.mit.edu	37	chr2	149679780	149679780	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggtttacaatgcatgtgcGaagcaaattgtcaaaggtaa	10	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:149679780G>A	ENST00000435030.1	+	2	569	c.201G>A	c.(199-201)gcG>gcA	p.A67A				O60282	KIF5C_HUMAN	kinesin family member 5C	67	Kinesin-motor.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		ATGCATGTGCGAAGCAAATTG	0.413													15	20					0	0	1	0	0	A	149679780	G	A	149679780	2	1	48	1	0	0	0	0	0	0	0	1	8348	1045	37	1		1	KIF5C	2	149679780	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	452800	149679780	93519593	624	5018										
KIF5C	3800	broad.mit.edu	37	chr2	149793854	149793854	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacgaattgcccatgatatCtttgaccatatctactccat	4	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:149793854C>A	ENST00000435030.1	+	4	716	c.348C>A	c.(346-348)atC>atA	p.I116I	KIF5C_ENST00000414838.2_Silent_p.I21I			O60282	KIF5C_HUMAN	kinesin family member 5C	116	Kinesin-motor.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.I116I(1)|p.I19I(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CCCATGATATCTTTGACCATA	0.493													3	6					0.115264	0.116507	1	1	0	A	149793854	C	A	149793854	2	1	48	1	0	0	0	0	0	0	0	1	8348	903	32	2		2	KIF5C	2	149793854	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	114074	149793854	93405519	625	5019										
KIF5C	3800	broad.mit.edu	37	chr2	149818500	149818500	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagagctaagaccatcaaGaatacagtctctgtgaacct	7	12	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:149818500G>T	ENST00000435030.1	+	11	1352	c.984G>T	c.(982-984)aaG>aaT	p.K328N	KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000397413.1_Missense_Mutation_p.K96N|KIF5C_ENST00000414838.2_Missense_Mutation_p.K233N			O60282	KIF5C_HUMAN	kinesin family member 5C	328	Kinesin-motor.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		AGACCATCAAGAATACAGTCT	0.358													29	50					9.65021e-13	1.22324e-12	1	1	0	T	149818500	G	T	149818500	3	4	48	1	0	0	0	0	1	0	0	0	8348	933	33	2	948	2	KIF5C	2	149818500	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24646	149818500	93380873	626	5020										
RBM43	375287	broad.mit.edu	37	chr2	152107545	152107545	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacttcaaggtatctcgaacTtaattgttcacatgcccttt	6	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152107545T>G	ENST00000331426.5	-	4	1100	c.949A>C	c.(949-951)Agt>Cgt	p.S317R		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	317							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TATCTCGAACTTAATTGTTCA	0.343													13	29					0	0	1	0	0	G	152107545	T	G	152107545	3	3	48	1	0	0	0	0	1	0	0	0	13188	1609	56	4	128	4	RBM43	2	152107545	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2289045	152107545	91091828	627	5021										
RBM43	375287	broad.mit.edu	37	chr2	152107614	152107614	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttccaaaataaatgtctCttttctaagctttaagtaaa	3	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152107614C>A	ENST00000331426.5	-	4	1031	c.880G>T	c.(880-882)Gag>Tag	p.E294*		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	294							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		ATAAATGTCTCTTTTCTAAGC	0.348													14	23					1.05317e-09	1.27574e-09	1	1	0	A	152107614	C	A	152107614	4	1	48	1	0	0	0	0	0	1	0	0	13188	922	32	2	197	2	RBM43	2	152107614	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	69	152107614	91091759	628	5022										
RIF1	55183	broad.mit.edu	37	chr2	152273332	152273332	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttttaggtatccagtatAattgattcattagaaatact	6	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152273332A>C	ENST00000243326.4	+	5	903	c.420A>C	c.(418-420)atA>atC	p.I140I	RIF1_ENST00000433166.2_Silent_p.I140I|RIF1_ENST00000428287.2_Silent_p.I140I|RIF1_ENST00000453091.2_Silent_p.I140I|RIF1_ENST00000444746.2_Silent_p.I140I|RIF1_ENST00000430328.2_Silent_p.I140I			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	140					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TATCCAGTATAATTGATTCAT	0.289													23	29					0	0	1	0	0	C	152273332	A	C	152273332	2	2	48	1	0	0	0	0	0	0	0	1	13408	352	13	4		4	RIF1	2	152273332	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	165718	152273332	90926041	629	5023										
RIF1	55183	broad.mit.edu	37	chr2	152303026	152303026	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggtggcaacagcagaagaGaacttgtgctgtgaggaact	14	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152303026G>T	ENST00000243326.4	+	19	2664	c.2181G>T	c.(2179-2181)gaG>gaT	p.E727D	RIF1_ENST00000428287.2_Missense_Mutation_p.E727D|RIF1_ENST00000453091.2_Missense_Mutation_p.E727D|RIF1_ENST00000444746.2_Missense_Mutation_p.E727D|RIF1_ENST00000430328.2_Missense_Mutation_p.E727D			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	727					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CAGCAGAAGAGAACTTGTGCT	0.408													23	46					1.10513e-12	1.40022e-12	1	1	0	T	152303026	G	T	152303026	3	4	48	1	0	0	0	0	1	0	0	0	13408	933	33	2	2255	2	RIF1	2	152303026	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29694	152303026	90896347	630	5024										
RIF1	55183	broad.mit.edu	37	chr2	152320659	152320659	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatcaaactagaagagcatCtcagggtttgctttccagca	9	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152320659C>A	ENST00000243326.4	+	29	5108	c.4625C>A	c.(4624-4626)tCt>tAt	p.S1542Y	RIF1_ENST00000428287.2_Missense_Mutation_p.S1542Y|RIF1_ENST00000453091.2_Missense_Mutation_p.S1542Y|RIF1_ENST00000444746.2_Missense_Mutation_p.S1542Y|RIF1_ENST00000430328.2_Missense_Mutation_p.S1542Y			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1542					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AGAAGAGCATCTCAGGGTTTG	0.428													18	37					6.94344e-10	8.4399e-10	1	1	0	A	152320659	C	A	152320659	3	1	48	1	0	0	0	0	1	0	0	0	13408	913	32	2	4739	2	RIF1	2	152320659	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17633	152320659	90878714	631	5025										
RIF1	55183	broad.mit.edu	37	chr2	152325056	152325056	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctaaatttaagagctcaaaGaagtgtttagtaagaagtgc	9	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152325056G>T	ENST00000243326.4	+	31	7299	c.6816G>T	c.(6814-6816)aaG>aaT	p.K2272N	RIF1_ENST00000428287.2_Intron|RIF1_ENST00000453091.2_Intron|RIF1_ENST00000444746.2_Missense_Mutation_p.K2272N|RIF1_ENST00000430328.2_Intron			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	2272	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AGAGCTCAAAGAAGTGTTTAG	0.358													7	53					0.000157383	0.000169016	1	1	0	T	152325056	G	T	152325056	3	4	48	1	0	0	0	0	1	0	0	0	13408	933	33	2	6938	2	RIF1	2	152325056	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4397	152325056	90874317	632	5026										
NEB	4703	broad.mit.edu	37	chr2	152534175	152534175	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggatgttgcctgtacttCttttcattcagagcatcacc	7	11	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152534175C>A	ENST00000397345.3	-	34	3880	c.3678G>T	c.(3676-3678)aaG>aaT	p.K1226N	NEB_ENST00000603639.1_Missense_Mutation_p.K1226N|NEB_ENST00000604864.1_Missense_Mutation_p.K1226N|NEB_ENST00000409198.1_Missense_Mutation_p.K1226N|NEB_ENST00000172853.10_Missense_Mutation_p.K1226N|NEB_ENST00000427231.2_Missense_Mutation_p.K1226N	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	1226					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCCTGTACTTCTTTTCATTCA	0.458													49	101					4.18559e-23	5.84444e-23	1	1	0	A	152534175	C	A	152534175	3	1	48	1	0	0	0	0	1	0	0	0	10348	912	32	2	22604	2	NEB	2	152534175	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	209119	152534175	90665198	633	5027										
NEB	4703	broad.mit.edu	37	chr2	152554096	152554096	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaacagtatcgagcttgaAtttgggggtctcgcagtaat	12	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152554096A>G	ENST00000397345.3	-	14	1421	c.1219T>C	c.(1219-1221)Ttc>Ctc	p.F407L	NEB_ENST00000603639.1_Missense_Mutation_p.F407L|NEB_ENST00000604864.1_Missense_Mutation_p.F407L|NEB_ENST00000409198.1_Missense_Mutation_p.F407L|NEB_ENST00000172853.10_Missense_Mutation_p.F407L|NEB_ENST00000427231.2_Missense_Mutation_p.F407L	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	407					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCGAGCTTGAATTTGGGGGTC	0.328													23	32					0	0	1	0	0	G	152554096	A	G	152554096	3	3	48	1	0	0	0	0	1	0	0	0	10348	101	4	4	25143	4	NEB	2	152554096	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	19921	152554096	90645277	634	5028										
NEB	4703	broad.mit.edu	37	chr2	152574022	152574022	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgctgttcagcgagaccttTtttgtaggcaacctgatgaa	10	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152574022T>G	ENST00000397345.3	-	10	932	c.730A>C	c.(730-732)Aaa>Caa	p.K244Q	NEB_ENST00000603639.1_Missense_Mutation_p.K244Q|NEB_ENST00000604864.1_Missense_Mutation_p.K244Q|NEB_ENST00000409198.1_Missense_Mutation_p.K244Q|NEB_ENST00000172853.10_Missense_Mutation_p.K244Q|NEB_ENST00000427231.2_Missense_Mutation_p.K244Q	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	244					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCGAGACCTTTTTTGTAGGCA	0.353													6	29					0	0	1	0	0	G	152574022	T	G	152574022	3	3	48	1	0	0	0	0	1	0	0	0	10348	1850	64	4	25648	4	NEB	2	152574022	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	19926	152574022	90625351	635	5029										
CACNB4	785	broad.mit.edu	37	chr2	152695763	152695763	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgatctcggctatgctgaGaactggaagacaagcggttc	12	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152695763G>T	ENST00000360283.6	-	13	1591	c.1334C>A	c.(1333-1335)tCt>tAt	p.S445Y	CACNB4_ENST00000427385.1_Missense_Mutation_p.S460Y|CACNB4_ENST00000539935.1_Missense_Mutation_p.S478Y|CACNB4_ENST00000397327.2_Missense_Mutation_p.S431Y|CACNB4_ENST00000534999.1_Missense_Mutation_p.S444Y|CACNB4_ENST00000201943.5_Missense_Mutation_p.S416Y			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	478					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GCTATGCTGAGAACTGGAAGA	0.463													10	23					2.74318e-10	3.35981e-10	1	1	0	T	152695763	G	T	152695763	3	4	48	1	0	0	0	0	1	0	0	0	2573	942	33	2	133	2	CACNB4	2	152695763	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	121741	152695763	90503610	636	5030										
CACNB4	785	broad.mit.edu	37	chr2	152739811	152739811	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgctgttctctctcctgtCgaattgcttcccggtcctct	7	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:152739811C>T	ENST00000360283.6	-	2	376	c.119G>A	c.(118-120)cGa>cAa	p.R40Q	CACNB4_ENST00000427385.1_Missense_Mutation_p.R56Q|CACNB4_ENST00000475848.1_5'UTR|CACNB4_ENST00000539935.1_Missense_Mutation_p.R74Q|CACNB4_ENST00000397327.2_Missense_Mutation_p.R27Q|CACNB4_ENST00000534999.1_Missense_Mutation_p.R40Q|CACNB4_ENST00000201943.5_Missense_Mutation_p.R74Q			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	74					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	TCTCTCCTGTCGAATTGCTTC	0.498													28	74					0	0	1	0	0	T	152739811	C	T	152739811	3	4	48	1	0	0	0	0	1	0	0	0	2573	884	31	1	1389	1	CACNB4	2	152739811	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	44048	152739811	90459562	637	5031										
FMNL2	114793	broad.mit.edu	37	chr2	153497338	153497338	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcaaagaggcagcagcaaGagttaattgcagaattaaga	10	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:153497338G>A	ENST00000288670.9	+	25	3446	c.3079G>A	c.(3079-3081)Gag>Aag	p.E1027K	FMNL2_ENST00000475377.2_Missense_Mutation_p.E402K	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	1027					actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GCAGCAGCAAGAGTTAATTGC	0.378													8	14					0	0	1	0	0	A	153497338	G	A	153497338	3	1	48	1	0	0	0	0	1	0	0	0	5984	943	33	3	3177	3	FMNL2	2	153497338	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	757527	153497338	89702035	638	5032										
GALNT13	114805	broad.mit.edu	37	chr2	155306999	155306999	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacaaaatggtgcctacaaTgcaggactgtagtggaagca	12	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:155306999T>G	ENST00000392825.3	+	13	2174	c.1607T>G	c.(1606-1608)aTg>aGg	p.M536R	AC009227.2_ENST00000434635.1_RNA|GALNT13_ENST00000409237.1_3'UTR	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	536	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						GTGCCTACAATGCAGGACTGT	0.448													11	30					0	0	1	0	0	G	155306999	T	G	155306999	3	3	48	1	0	0	0	0	1	0	0	0	6250	1464	51	4	1649	4	GALNT13	2	155306999	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1809661	155306999	87892374	639	5033										
GALNT5	11227	broad.mit.edu	37	chr2	158142583	158142583	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtttccaaaagttcggattCttcgcctcaaagagagacat	8	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:158142583C>A	ENST00000259056.4	+	3	2163	c.1678C>A	c.(1678-1680)Ctt>Att	p.L560I		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	560	Catalytic subdomain A.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						AGTTCGGATTCTTCGCCTCAA	0.358													14	32					1.52009e-12	1.92208e-12	1	1	0	A	158142583	C	A	158142583	3	1	48	1	0	0	0	0	1	0	0	0	6255	913	32	2	1688	2	GALNT5	2	158142583	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2835584	158142583	85056790	640	5034										
WDSUB1	151525	broad.mit.edu	37	chr2	160112755	160112755	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgtaagattcaacagttCttttccatcaatgttattca	4	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:160112755C>A	ENST00000409990.3	-	9	1340	c.1084G>T	c.(1084-1086)Gaa>Taa	p.E362*	WDSUB1_ENST00000358147.4_Nonsense_Mutation_p.E270*|WDSUB1_ENST00000409124.1_Nonsense_Mutation_p.E362*|WDSUB1_ENST00000392796.3_Nonsense_Mutation_p.E362*|WDSUB1_ENST00000359774.4_Nonsense_Mutation_p.E362*	NM_001128213.1	NP_001121685.1	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain containing 1	362	SAM.					ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|prostate(1)|stomach(3)	16						TTCAACAGTTCTTTTCCATCA	0.338													10	26					1.33987e-11	1.67053e-11	1	1	0	A	160112755	C	A	160112755	4	1	48	1	0	0	0	0	0	1	0	0	17400	922	32	2	358	2	WDSUB1	2	160112755	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1970172	160112755	83086618	641	5035										
BAZ2B	29994	broad.mit.edu	37	chr2	160289317	160289317	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatcatcttcctcatcttcTtcttcatcatcttcctcttc	0	16	11	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:160289317T>G	ENST00000392783.2	-	9	2346	c.1851A>C	c.(1849-1851)gaA>gaC	p.E617D	BAZ2B_ENST00000392782.1_Missense_Mutation_p.E615D|BAZ2B_ENST00000355831.2_Missense_Mutation_p.E617D|BAZ2B_ENST00000343439.5_Missense_Mutation_p.E615D	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	617	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						cctcatcttcttcttcatcat	0.333													9	18					0	0	1	0	0	G	160289317	T	G	160289317	3	3	48	1	0	0	0	0	1	0	0	0	1330	1606	56	4	4771	4	BAZ2B	2	160289317	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	176562	160289317	82910056	642	5036										
FAP	2191	broad.mit.edu	37	chr2	163076364	163076364	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaaatttaaacacttactAatttactcccaacaggcgac	3	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:163076364A>G	ENST00000188790.4	-	7	692	c.486_splice	c.e7+1	p.L162_splice	FAP_ENST00000443424.1_Splice_Site_p.L137_splice	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	162					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.L162*(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						AACACTTACTAATTTACTCCC	0.328													8	20					0	0	1	0	0	G	163076364	A	G	163076364	5	3	48	1	0	0	0	0	0	0	1	0	5705	376	13	4	1877	4	FAP	2	163076364	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2787047	163076364	80123009	643	5037										
KCNH7	90134	broad.mit.edu	37	chr2	163374665	163374665	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaatttgaacccaaaaaatTtccctataaatggagacagg	8	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:163374665T>G	ENST00000332142.5	-	4	566	c.467A>C	c.(466-468)aAa>aCa	p.K156T	KCNH7_ENST00000328032.4_Missense_Mutation_p.K156T|KCNH7_ENST00000477019.1_5'UTR	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	156					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CCCAAAAAATTTCCCTATAAA	0.368													15	26					0	0	1	0	0	G	163374665	T	G	163374665	3	3	48	1	0	0	0	0	1	0	0	0	8080	1841	64	4	3241	4	KCNH7	2	163374665	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	298301	163374665	79824708	644	5038										
COBLL1	22837	broad.mit.edu	37	chr2	165551180	165551180	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctccggagaaggcagcaTatccctttctgcctctttat	8	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:165551180T>C	ENST00000375458.2	-	11	2943	c.2722A>G	c.(2722-2724)Atg>Gtg	p.M908V	COBLL1_ENST00000409184.3_Missense_Mutation_p.M946V|COBLL1_ENST00000342193.4_Missense_Mutation_p.M946V|COBLL1_ENST00000194871.6_Missense_Mutation_p.M1013V|COBLL1_ENST00000392717.2_Missense_Mutation_p.M984V	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	984										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						GAAGGCAGCATATCCCTTTCT	0.468													13	29					0	0	1	0	0	C	165551180	T	C	165551180	3	2	48	1	0	0	0	0	1	0	0	0	3677	1406	49	4	676	4	COBLL1	2	165551180	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2176515	165551180	77648193	645	5039										
COBLL1	22837	broad.mit.edu	37	chr2	165551579	165551579	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgtttggatggcagtttCtttcacattctcatgagtgt	9	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:165551579C>A	ENST00000375458.2	-	11	2544	c.2323G>T	c.(2323-2325)Gaa>Taa	p.E775*	COBLL1_ENST00000409184.3_Nonsense_Mutation_p.E813*|COBLL1_ENST00000342193.4_Nonsense_Mutation_p.E813*|COBLL1_ENST00000194871.6_Nonsense_Mutation_p.E880*|COBLL1_ENST00000392717.2_Nonsense_Mutation_p.E851*	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	851										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						ATGGCAGTTTCTTTCACATTC	0.418													36	58					2.20474e-14	2.87106e-14	1	1	0	A	165551579	C	A	165551579	4	1	48	1	0	0	0	0	0	1	0	0	3677	922	32	2	1075	2	COBLL1	2	165551579	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	399	165551579	77647794	646	5040										
SCN3A	6328	broad.mit.edu	37	chr2	166020945	166020945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccagttccatggatcacGaagaaacgtaaaatcttcta	7	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:166020945G>A	ENST00000360093.3	-	6	1050	c.559C>T	c.(559-561)Cgt>Tgt	p.R187C	SCN3A_ENST00000409101.3_Missense_Mutation_p.R187C|SCN3A_ENST00000283254.7_Missense_Mutation_p.R187C	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	187						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CATGGATCACGAAGAAACGTA	0.373													12	33					0	0	1	0	0	A	166020945	G	A	166020945	3	1	48	1	0	0	0	0	1	0	0	0	13971	1058	37	1	5631	1	SCN3A	2	166020945	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	469366	166020945	77178428	647	5041										
SCN2A	6326	broad.mit.edu	37	chr2	166165696	166165696	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgtaacagaatttgtaaaCctaggcaatgtttcagctct	7	7	2	1	rs2228981		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:166165696C>T	ENST00000357398.3	+	6	917	c.627C>T	c.(625-627)aaC>aaT	p.N209N	SCN2A_ENST00000375437.2_Intron|SCN2A_ENST00000283256.6_Intron|SCN2A_ENST00000375427.2_Silent_p.N209N			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	209					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AATTTGTAAACCTAGGCAATG	0.348													5	21					0	0	1	0	0	T	166165696	C	T	166165696	2	4	48	1	0	0	0	0	0	0	0	1	13969	506	18	3		3	SCN2A	2	166165696	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	144751	166165696	77033677	648	5042										
SCN1A	6323	broad.mit.edu	37	chr2	166848303	166848303	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcagctgcaaactgagataAtttttcaaattccatgaact	6	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:166848303A>C	ENST00000423058.2	-	26	5499	c.5482T>G	c.(5482-5484)Tta>Gta	p.L1828V	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.L1800V|SCN1A_ENST00000375405.3_Missense_Mutation_p.L1817V|SCN1A_ENST00000303395.4_Missense_Mutation_p.L1828V	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1828						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AACTGAGATAATTTTTCAAAT	0.468													48	78					0	0	1	0	0	C	166848303	A	C	166848303	3	2	48	1	0	0	0	0	1	0	0	0	13967	98	4	4	551	4	SCN1A	2	166848303	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	682607	166848303	76351070	649	5043										
SCN1A	6323	broad.mit.edu	37	chr2	166866290	166866290	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagctcttagtgtcctgagaGatttgatggctccaagttct	11	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:166866290G>T	ENST00000423058.2	-	20	3958	c.3941C>A	c.(3940-3942)tCt>tAt	p.S1314Y	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.S1286Y|SCN1A_ENST00000375405.3_Missense_Mutation_p.S1303Y|SCN1A_ENST00000303395.4_Missense_Mutation_p.S1314Y	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1314						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGTCCTGAGAGATTTGATGGC	0.383													16	25					1.37285e-15	1.81125e-15	1	1	0	T	166866290	G	T	166866290	3	4	48	1	0	0	0	0	1	0	0	0	13967	942	33	2	2116	2	SCN1A	2	166866290	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17987	166866290	76333083	650	5044										
SCN1A	6323	broad.mit.edu	37	chr2	166897798	166897798	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcattggatagtgctccatGgccatgaaaagagtatttaa	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:166897798G>T	ENST00000423058.2	-	13	2375	c.2358C>A	c.(2356-2358)gcC>gcA	p.A786A	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000409050.1_Silent_p.A758A|SCN1A_ENST00000375405.3_Silent_p.A775A|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000303395.4_Silent_p.A786A	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	786						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGTGCTCCATGGCCATGAAAA	0.383													19	42					1.33834e-09	1.61283e-09	1	1	0	T	166897798	G	T	166897798	2	4	48	1	0	0	0	0	0	0	0	1	13967	1335	47	5		5	SCN1A	2	166897798	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	31508	166897798	76301575	651	5045										
SCN1A	6323	broad.mit.edu	37	chr2	166911148	166911148	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttcaaaaaaggcacttacGcaaatgtaatgacagtgaaa	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:166911148G>A	ENST00000423058.2	-	4	619	c.602_splice	c.e4+1	p.A201_splice	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000409050.1_Splice_Site_p.A201_splice|SCN1A_ENST00000375405.3_Splice_Site_p.A201_splice|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000303395.4_Splice_Site_p.A201_splice	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	201						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGGCACTTACGCAAATGTAAT	0.343													10	27					0	0	1	0	0	A	166911148	G	A	166911148	5	1	48	1	0	0	0	0	0	0	1	0	13967	1101	38	1	5519	1	SCN1A	2	166911148	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13350	166911148	76288225	652	5046										
SCN9A	6335	broad.mit.edu	37	chr2	167056352	167056352	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggacacaaaatacgtttcAatcaaatcagctagaaacat	7	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:167056352A>C	ENST00000375387.4	-	27	5140	c.4800T>G	c.(4798-4800)atT>atG	p.I1600M	SCN9A_ENST00000409672.1_Missense_Mutation_p.I1588M|SCN9A_ENST00000409435.1_Missense_Mutation_p.I1599M|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Missense_Mutation_p.I1600M			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1599						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AATACGTTTCAATCAAATCAG	0.408													11	100					0	0	1	0	0	C	167056352	A	C	167056352	3	2	48	1	0	0	0	0	1	0	0	0	13978	126	5	4	1173	4	SCN9A	2	167056352	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	145204	167056352	76143021	653	5047										
SCN9A	6335	broad.mit.edu	37	chr2	167149755	167149755	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcacctgttggtaaaggtTttcccagtaatcttgggtca	9	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:167149755T>G	ENST00000375387.4	-	9	1436	c.1096A>C	c.(1096-1098)Aac>Cac	p.N366H	SCN9A_ENST00000409672.1_Missense_Mutation_p.N365H|SCN9A_ENST00000409435.1_Missense_Mutation_p.N365H|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Missense_Mutation_p.N366H			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	365						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGGTAAAGGTTTTCCCAGTAA	0.408													5	8					0	0	1	0	0	G	167149755	T	G	167149755	3	3	48	1	0	0	0	0	1	0	0	0	13978	1841	64	4	4916	4	SCN9A	2	167149755	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	93403	167149755	76049618	654	5048										
SCN7A	6332	broad.mit.edu	37	chr2	167284347	167284347	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccaataaaacacttaaacCaattgttctctacaatcttg	3	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:167284347C>A	ENST00000409855.1	-	17	2930	c.2804G>T	c.(2803-2805)tGg>tTg	p.W935L		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	935					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ACACTTAAACCAATTGTTCTC	0.448													16	17					2.23348e-06	2.50077e-06	1	1	0	A	167284347	C	A	167284347	3	1	48	1	0	0	0	0	1	0	0	0	13976	595	21	5	2280	5	SCN7A	2	167284347	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	134592	167284347	75915026	655	5049										
XIRP2	129446	broad.mit.edu	37	chr2	168099780	168099780	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtttgaaacccaacccatCgacacacttggggcttattc	7	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168099780C>T	ENST00000409195.1	+	9	1967	c.1878C>T	c.(1876-1878)atC>atT	p.I626I	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.I626I|XIRP2_ENST00000409273.1_Silent_p.I404I	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	451					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CCCAACCCATCGACACACTTG	0.448													8	47					0	0	1	0	0	T	168099780	C	T	168099780	2	4	48	1	0	0	0	0	0	0	0	1	17489	874	31	1		1	XIRP2	2	168099780	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	815433	168099780	75099593	656	5050										
XIRP2	129446	broad.mit.edu	37	chr2	168101562	168101563	+	Frame_Shift_Ins	INS	-	-	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagttcagaggaagttttgINSaaaaagatcaaaaccttaaa							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168101562_168101563insA	ENST00000409195.1	+	9	3749_3750	c.3660_3661insA	c.(3658-3663)ttaaaafs	p.LK1220fs	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Ins_p.LK998fs|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Frame_Shift_Ins_p.LK1220fs|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1045					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGAAGTTTTGAAAAAGATCAA	0.312													7	30	---	---	---	---						A	168101563	-	A	168101562	7	5	48	1	0	1	1	0	0	0	0	0	17489	1281	45	0	3690	0	XIRP2	2	168101562	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	1782	168101562	75097811	657	5051										
XIRP2	129446	broad.mit.edu	37	chr2	168102751	168102751	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaacctactttccaaaaggGactgtactgaaagagagatt	9	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168102751G>A	ENST00000409195.1	+	9	4938	c.4849G>A	c.(4849-4851)Gac>Aac	p.D1617N	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D1617N|XIRP2_ENST00000409273.1_Missense_Mutation_p.D1395N	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1442					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTCCAAAAGGGACTGTACTGA	0.333													13	23					0	0	1	0	0	A	168102751	G	A	168102751	3	1	48	1	0	0	0	0	1	0	0	0	17489	1174	41	3	4879	3	XIRP2	2	168102751	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1189	168102751	75096622	658	5052										
XIRP2	129446	broad.mit.edu	37	chr2	168103196	168103196	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaacaactccacacagagtCaaatgaaacactgacagcta	6	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168103196C>A	ENST00000409195.1	+	9	5383	c.5294C>A	c.(5293-5295)tCa>tAa	p.S1765*	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Nonsense_Mutation_p.S1765*|XIRP2_ENST00000409273.1_Nonsense_Mutation_p.S1543*	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1590					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CACACAGAGTCAAATGAAACA	0.403													21	37					1.2644e-06	1.4261e-06	1	1	0	A	168103196	C	A	168103196	4	1	48	1	0	0	0	0	0	1	0	0	17489	838	29	2	5324	2	XIRP2	2	168103196	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	445	168103196	75096177	659	5053										
XIRP2	129446	broad.mit.edu	37	chr2	168103954	168103954	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaaagaactgaggttaatCttccaaaagcccccaaaggc	8	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168103954C>A	ENST00000409195.1	+	9	6141	c.6052C>A	c.(6052-6054)Ctt>Att	p.L2018I	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.L2018I|XIRP2_ENST00000409273.1_Missense_Mutation_p.L1796I	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1843					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGAGGTTAATCTTCCAAAAGC	0.438													18	35					2.35188e-11	2.92451e-11	1	1	0	A	168103954	C	A	168103954	3	1	48	1	0	0	0	0	1	0	0	0	17489	913	32	2	6082	2	XIRP2	2	168103954	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	758	168103954	75095419	660	5054										
XIRP2	129446	broad.mit.edu	37	chr2	168106676	168106676	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagattacacagaacaaatCtttcttttcctctgtgaaag	6	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168106676C>A	ENST00000409195.1	+	9	8863	c.8774C>A	c.(8773-8775)tCt>tAt	p.S2925Y	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.S2925Y|XIRP2_ENST00000409273.1_Missense_Mutation_p.S2703Y	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2750					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CAGAACAAATCTTTCTTTTCC	0.378													29	53					1.38854e-25	1.95732e-25	1	1	0	A	168106676	C	A	168106676	3	1	48	1	0	0	0	0	1	0	0	0	17489	913	32	2	8804	2	XIRP2	2	168106676	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2722	168106676	75092697	661	5055										
XIRP2	129446	broad.mit.edu	37	chr2	168107532	168107532	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggttccaattgtagagaaGaggtctgaaatcatcatgtc	10	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168107532G>A	ENST00000409195.1	+	9	9719	c.9630G>A	c.(9628-9630)aaG>aaA	p.K3210K	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.K3210K|XIRP2_ENST00000409273.1_Silent_p.K2988K	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3035					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTGTAGAGAAGAGGTCTGAAA	0.458													35	64					0	0	1	0	0	A	168107532	G	A	168107532	2	1	48	1	0	0	0	0	0	0	0	1	17489	933	33	3		3	XIRP2	2	168107532	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	856	168107532	75091841	662	5056										
XIRP2	129446	broad.mit.edu	37	chr2	168114449	168114449	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaaatccaaaggaaattatGatgaaggttttggacataag	9	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:168114449G>T	ENST00000409728.1	+	11	1581	c.1492G>T	c.(1492-1494)Gat>Tat	p.D498Y	XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.D498Y|XIRP2_ENST00000409605.1_Missense_Mutation_p.D243Y|XIRP2_ENST00000409043.1_Missense_Mutation_p.D465Y|XIRP2_ENST00000409756.2_Missense_Mutation_p.D465Y|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409273.1_3'UTR	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGAAATTATGATGAAGGTTT	0.328													26	30					3.28513e-13	4.19729e-13	1	1	0	T	168114449	G	T	168114449	3	4	48	1	0	0	0	0	1	0	0	0	17489	1290	45	2	10810	2	XIRP2	2	168114449	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6917	168114449	75084924	663	5057										
ABCB11	8647	broad.mit.edu	37	chr2	169820792	169820792	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaccaggtaagaaagctgaGacttggagcgttgccggatg	15	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:169820792G>T	ENST00000263817.6	-	18	2226	c.2102C>A	c.(2101-2103)tCt>tAt	p.S701Y		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	701					bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AGAAAGCTGAGACTTGGAGCG	0.463													3	4					0.014758	0.015099	1	1	0	T	169820792	G	T	169820792	3	4	48	1	0	0	0	0	1	0	0	0	42	942	33	2	1907	2	ABCB11	2	169820792	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1706343	169820792	73378581	664	5058										
ABCB11	8647	broad.mit.edu	37	chr2	169828434	169828434	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcttccattgttgcatcttCtctgccatagcgaatatttt	6	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:169828434C>A	ENST00000263817.6	-	14	1685	c.1561G>T	c.(1561-1563)Gaa>Taa	p.E521*		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	521	ABC transporter 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GTTGCATCTTCTCTGCCATAG	0.473													16	41					6.31663e-08	7.35827e-08	1	1	0	A	169828434	C	A	169828434	4	1	48	1	0	0	0	0	0	1	0	0	42	922	32	2	2464	2	ABCB11	2	169828434	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7642	169828434	73370939	665	5059										
LRP2	4036	broad.mit.edu	37	chr2	170002290	170002290	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgagttgatgaaagattcGaacttgagtgagccaagggt	13	5	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170002290G>A	ENST00000263816.3	-	70	13240	c.12955C>T	c.(12955-12957)Cga>Tga	p.R4319*		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4319					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGAAAGATTCGAACTTGAGTG	0.363													8	53					0	0	1	0	0	A	170002290	G	A	170002290	4	1	48	1	0	0	0	0	0	1	0	0	9000	1066	37	1	1052	1	LRP2	2	170002290	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	173856	170002290	73197083	666	5060										
LRP2	4036	broad.mit.edu	37	chr2	170042459	170042459	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggacgacaggaacaataGaaactggttaaggtgtctgt	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170042459G>T	ENST00000263816.3	-	50	9684	c.9399C>A	c.(9397-9399)ttC>ttA	p.F3133L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3133	EGF-like 11.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGGAACAATAGAAACTGGTTA	0.443													25	30					4.72057e-08	5.51616e-08	1	1	0	T	170042459	G	T	170042459	3	4	48	1	0	0	0	0	1	0	0	0	9000	933	33	2	4688	2	LRP2	2	170042459	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40169	170042459	73156914	667	5061										
LRP2	4036	broad.mit.edu	37	chr2	170063458	170063458	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgatacgaatccttgcaaTtatatctaaagaatcatcaa	4	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170063458T>G	ENST00000263816.3	-	39	7057	c.6772A>C	c.(6772-6774)Att>Ctt	p.I2258L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2258					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCCTTGCAATTATATCTAAA	0.433													45	86					0	0	1	0	0	G	170063458	T	G	170063458	3	3	48	1	0	0	0	0	1	0	0	0	9000	1493	52	4	7359	4	LRP2	2	170063458	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	20999	170063458	73135915	668	5062										
LRP2	4036	broad.mit.edu	37	chr2	170081836	170081836	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacctcgattgactgagttCtaggattggtagaataaagg	11	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170081836C>A	ENST00000263816.3	-	33	5807	c.5522G>T	c.(5521-5523)aGa>aTa	p.R1841I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1841					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGACTGAGTTCTAGGATTGGT	0.388													10	36					0.00621372	0.0064192	1	1	0	A	170081836	C	A	170081836	3	1	48	1	0	0	0	0	1	0	0	0	9000	913	32	2	8633	2	LRP2	2	170081836	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18378	170081836	73117537	669	5063										
LRP2	4036	broad.mit.edu	37	chr2	170094769	170094769	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggtgacactgtcggcaatAattttgttctgacttgccac	10	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170094769A>C	ENST00000263816.3	-	27	4623	c.4338T>G	c.(4336-4338)atT>atG	p.I1446M		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1446					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGTCGGCAATAATTTTGTTCT	0.383													11	26					0	0	1	0	0	C	170094769	A	C	170094769	3	2	48	1	0	0	0	0	1	0	0	0	9000	358	13	4	9841	4	LRP2	2	170094769	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	12933	170094769	73104604	670	5064										
LRP2	4036	broad.mit.edu	37	chr2	170135978	170135978	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaatttaccatatctatgCggttgaccttggtttccact	6	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170135978C>T	ENST00000263816.3	-	12	1754	c.1469G>A	c.(1468-1470)cGc>cAc	p.R490H	LRP2_ENST00000443831.1_Missense_Mutation_p.R490H	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	490					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATATCTATGCGGTTGACCTT	0.428													29	40					0	0	1	0	0	T	170135978	C	T	170135978	3	4	48	1	0	0	0	0	1	0	0	0	9000	768	27	1	12770	1	LRP2	2	170135978	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	41209	170135978	73063395	671	5065										
PPIG	9360	broad.mit.edu	37	chr2	170487452	170487452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaacatcggaaaaattcccGaaaacacaagaaagaaaaga	7	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170487452G>A	ENST00000260970.3	+	10	936	c.716G>A	c.(715-717)cGa>cAa	p.R239Q	PPIG_ENST00000482772.1_3'UTR|PPIG_ENST00000462903.1_Missense_Mutation_p.R239Q|PPIG_ENST00000448752.2_Missense_Mutation_p.R239Q|PPIG_ENST00000409714.3_Missense_Mutation_p.R224Q	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	239	Arg/Lys-rich (basic).				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity	p.R239Q(1)		NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AAAAATTCCCGAAAACACAAG	0.333													12	17					0	0	1	0	0	A	170487452	G	A	170487452	3	1	48	1	0	0	0	0	1	0	0	0	12372	1058	37	1	746	1	PPIG	2	170487452	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	351474	170487452	72711921	672	5066										
PHOSPHO2	493911	broad.mit.edu	37	chr2	170557600	170557600	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaactacgtgattcttatcGaaaaggattttggacagaat	9	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170557600G>A	ENST00000359744.3	+	4	507	c.119G>A	c.(118-120)cGa>cAa	p.R40Q	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Intron	NM_001008489.3|NM_001199285.1|NM_001199286.1|NM_001199288.1	NP_001008489.1|NP_001186214.1|NP_001186215.1|NP_001186217.1	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	40							metal ion binding|pyridoxal phosphatase activity	p.R40Q(1)		breast(1)|large_intestine(1)|lung(6)|skin(2)	10						GATTCTTATCGAAAAGGATTT	0.363													24	36					0	0	1	0	0	A	170557600	G	A	170557600	3	1	48	1	0	0	0	0	1	0	0	0	11904	1058	37	1	121	1	PHOSPHO2	2	170557600	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	70148	170557600	72641773	673	5067										
KLHL23	151230	broad.mit.edu	37	chr2	170591663	170591663	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagtgtccttcaggcataAttttccattgtcaccgagcc	7	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170591663A>C	ENST00000392647.2	+	2	383	c.139A>C	c.(139-141)Att>Ctt	p.I47L	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Missense_Mutation_p.I47L	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	47	BTB.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						TTCAGGCATAATTTTCCATTG	0.343													31	54					0	0	1	0	0	C	170591663	A	C	170591663	3	2	48	1	0	0	0	0	1	0	0	0	8420	101	4	4	141	4	KLHL23	2	170591663	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	34063	170591663	72607710	674	5068										
UBR3	130507	broad.mit.edu	37	chr2	170843295	170843295	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattagttgtactgttacaaGcatcctcaggtaaaatcaaa	7	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:170843295G>A	ENST00000272793.5	+	25	3825	c.3775G>A	c.(3775-3777)Gca>Aca	p.A1259T	UBR3_ENST00000392631.1_Missense_Mutation_p.A80T|UBR3_ENST00000418381.1_Missense_Mutation_p.A1259T			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1259					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						ACTGTTACAAGCATCCTCAGG	0.353													28	35					0	0	1	0	0	A	170843295	G	A	170843295	3	1	48	1	0	0	0	0	1	0	0	0	16963	971	34	3	3873	3	UBR3	2	170843295	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	251632	170843295	72356078	675	5069										
MYO3B	140469	broad.mit.edu	37	chr2	171248036	171248036	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttttttttcaggagagaGaaaaattttcatatatttta	5	3	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:171248036G>T	ENST00000334231.6	+	15	1611	c.1611G>T	c.(1609-1611)gaG>gaT	p.E537D	MYO3B_ENST00000408978.4_Missense_Mutation_p.E528D|MYO3B_ENST00000409044.3_Missense_Mutation_p.E528D|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	528	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TCAGGAGAGAGAAAAATTTTC	0.323													8	9					0.0381472	0.0387537	1	1	0	T	171248036	G	T	171248036	3	4	48	1	0	0	0	0	1	0	0	0	10124	933	33	2	1642	2	MYO3B	2	171248036	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	404741	171248036	71951337	676	5070										
SP5	389058	broad.mit.edu	37	chr2	171573092	171573092	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctcgtacccctacgagttCtcgccggtcaagatgctgcc	9	17	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:171573092C>A	ENST00000375281.3	+	2	537	c.375C>A	c.(373-375)ttC>ttA	p.F125L		NM_001003845.2	NP_001003845.1	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|lung(1)|prostate(1)	5						CCTACGAGTTCTCGCCGGTCA	0.726													10	34					3.86212e-05	4.21111e-05	1	1	0	A	171573092	C	A	171573092	3	1	48	1	0	0	0	0	1	0	0	0	15020	912	32	2	381	2	SP5	2	171573092	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	325056	171573092	71626281	677	5071										
GAD1	2571	broad.mit.edu	37	chr2	171715386	171715386	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccagacagccctcaacgaCgggaaaagctacacaaggta	10	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:171715386C>T	ENST00000358196.3	+	16	2144	c.1594C>T	c.(1594-1596)Cgg>Tgg	p.R532W		NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	532			R -> Q (in dbSNP:rs769402).		glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCCTCAACGACGGGAAAAGCT	0.453													11	27					0	0	1	0	0	T	171715386	C	T	171715386	3	4	48	1	0	0	0	0	1	0	0	0	6213	527	19	1	1693	1	GAD1	2	171715386	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	142294	171715386	71483987	678	5072										
RAPGEF4	11069	broad.mit.edu	37	chr2	173866010	173866010	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagattctgttttaaatgaCtttattatgatgcactgtgt	7	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:173866010C>T	ENST00000264111.6	+	17	1780	c.1593C>T	c.(1591-1593)gaC>gaT	p.D531D	RAPGEF4_ENST00000409036.1_Silent_p.D532D|RAPGEF4_ENST00000540783.1_Silent_p.D379D|RAPGEF4_ENST00000539331.1_Silent_p.D379D|RAPGEF4_ENST00000397087.3_Silent_p.D388D|RAPGEF4_ENST00000538974.1_Silent_p.D361D|RAPGEF4_ENST00000397081.3_Silent_p.D532D|RAPGEF4_ENST00000535187.1_Silent_p.D312D			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	532	N-terminal Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTTTAAATGACTTTATTATGA	0.383													13	51					0	0	1	0	0	T	173866010	C	T	173866010	2	4	48	1	0	0	0	0	0	0	0	1	13097	564	20	3		3	RAPGEF4	2	173866010	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2150624	173866010	69333363	679	5073										
OLA1	29789	broad.mit.edu	37	chr2	174987962	174987963	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagattaaccaagtagaccaINSttggttttgaagtcaaaaat							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:174987962_174987963insT	ENST00000284719.3	-	7	919_920	c.673_674insA	c.(673-675)ggtfs	p.G225fs	OLA1_ENST00000344357.5_Frame_Shift_Ins_p.G67fs|OLA1_ENST00000392560.2_5'UTR|OLA1_ENST00000428402.2_Frame_Shift_Ins_p.G225fs|OLA1_ENST00000409546.1_Frame_Shift_Ins_p.G245fs	NM_013341.3	NP_037473.3	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1	225					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						CAAGTAGACCATTGGTTTTGAA	0.317													8	10	---	---	---	---						T	174987963	-	T	174987962	7	5	48	1	0	1	1	0	0	0	0	0	10897	217	8	0	536	0	OLA1	2	174987962	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	1121952	174987962	68211411	680	5074										
CIR1	9541	broad.mit.edu	37	chr2	175215392	175215392	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatacttctaaattacctgaGaagtttctgtttttgtttgg	7	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175215392G>A	ENST00000342016.3	-	9	765	c.673C>T	c.(673-675)Ctc>Ttc	p.L225F	CIR1_ENST00000362053.5_3'UTR	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	225	Interaction with RP9 (By similarity).|Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						AATTACCTGAGAAGTTTCTGT	0.328													5	16					0	0	1	0	0	A	175215392	G	A	175215392	3	1	48	1	0	0	0	0	1	0	0	0	3454	942	33	3	687	3	CIR1	2	175215392	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	227430	175215392	67983981	681	5075										
SCRN3	79634	broad.mit.edu	37	chr2	175265748	175265748	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagagctgatacagctgaAaaagccctcaatgtcattgt	9	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175265748A>G	ENST00000272732.6	+	4	454	c.372A>G	c.(370-372)gaA>gaG	p.E124E	SCRN3_ENST00000409673.3_Silent_p.E117E	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	124					proteolysis		dipeptidase activity	p.E124D(1)|p.E117D(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			ATACAGCTGAAAAAGCCCTCA	0.323													17	16					0	0	1	0	0	G	175265748	A	G	175265748	2	3	48	1	0	0	0	0	0	0	0	1	13993	11	1	4		4	SCRN3	2	175265748	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	50356	175265748	67933625	682	5076										
SCRN3	79634	broad.mit.edu	37	chr2	175289296	175289296	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgaagatctagttaaaaaGaaatcacattttaagcctga	6	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175289296G>T	ENST00000272732.6	+	7	1093	c.1011G>T	c.(1009-1011)aaG>aaT	p.K337N	SCRN3_ENST00000409673.3_Missense_Mutation_p.K330N|SCRN3_ENST00000548921.1_3'UTR	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	337					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TAGTTAAAAAGAAATCACATT	0.328													9	27					3.09899e-07	3.54467e-07	1	1	0	T	175289296	G	T	175289296	3	4	48	1	0	0	0	0	1	0	0	0	13993	933	33	2	1033	2	SCRN3	2	175289296	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23548	175289296	67910077	683	5077										
GPR155	151556	broad.mit.edu	37	chr2	175300922	175300922	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttggagagtgtttgcattAatagcaggaggactctgttc	13	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175300922A>C	ENST00000392552.2	-	16	2773	c.2535T>G	c.(2533-2535)atT>atG	p.I845M	GPR155_ENST00000392551.2_Missense_Mutation_p.I845M|GPR155_ENST00000295500.4_Missense_Mutation_p.I845M	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	845					intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						TGTTTGCATTAATAGCAGGAG	0.423													6	98					0	0	1	0	0	C	175300922	A	C	175300922	3	2	48	1	0	0	0	0	1	0	0	0	6699	358	13	4	81	4	GPR155	2	175300922	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	11626	175300922	67898451	684	5078										
GPR155	151556	broad.mit.edu	37	chr2	175306891	175306891	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatgtttatctaatccaaaGattccaaaggaaataaatcc	4	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175306891G>T	ENST00000392552.2	-	14	2368	c.2130C>A	c.(2128-2130)atC>atA	p.I710I	GPR155_ENST00000392551.2_Silent_p.I710I|GPR155_ENST00000459996.1_5'UTR|GPR155_ENST00000295500.4_Silent_p.I710I	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	710					intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						CTAATCCAAAGATTCCAAAGG	0.279													11	39					3.07112e-06	3.42433e-06	1	1	0	T	175306891	G	T	175306891	2	4	48	1	0	0	0	0	0	0	0	1	6699	932	33	2		2	GPR155	2	175306891	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5969	175306891	67892482	685	5079										
CHRNA1	1134	broad.mit.edu	37	chr2	175622306	175622306	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgctcacttgttatagagaAcaaggtctgggcgccagatc	11	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175622306A>G	ENST00000348749.5	-	4	409	c.332T>C	c.(331-333)gTt>gCt	p.V111A	CHRNA1_ENST00000409542.1_Intron|CHRNA1_ENST00000409323.1_Missense_Mutation_p.V111A|CHRNA1_ENST00000409219.1_Missense_Mutation_p.V111A|CHRNA1_ENST00000261007.5_Missense_Mutation_p.V136A|AC018890.6_ENST00000442996.1_RNA	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	136					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						GTTATAGAGAACAAGGTCTGG	0.488													8	19					0	0	1	0	0	G	175622306	A	G	175622306	3	3	48	1	0	0	0	0	1	0	0	0	3403	43	2	4	1065	4	CHRNA1	2	175622306	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	315415	175622306	67577067	686	5080										
CHN1	1123	broad.mit.edu	37	chr2	175664856	175664856	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaaaaatttaaaataaaatGtcttcgtttttgataagcag	5	3	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:175664856G>T	ENST00000409900.3	-	13	1681	c.1368C>A	c.(1366-1368)gaC>gaA	p.D456E	CHN1_ENST00000409597.1_Missense_Mutation_p.D272E|CHN1_ENST00000295497.7_Missense_Mutation_p.D331E|CHN1_ENST00000409156.3_Missense_Mutation_p.D430E|CHN1_ENST00000488080.1_5'UTR	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	456	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			aaaataaaatGTCTTCGTTTT	0.358			T	TAF15	extraskeletal myxoid chondrosarcoma								5	14					0.0215528	0.0219788	1	1	0	T	175664856	G	T	175664856	3	4	48	1	0	0	0	0	1	0	0	0	3384	1368	48	5	15	5	CHN1	2	175664856	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42550	175664856	67534517	687	5081										
HOXD13	3239	broad.mit.edu	37	chr2	176959355	176959355	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacaagcggcggcgtatctCggctgctacgaacctatctg	13	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:176959355C>T	ENST00000392539.3	+	2	929	c.929C>T	c.(928-930)tCg>tTg	p.S310L		NM_000523.3	NP_000514.2	P35453	HXD13_HUMAN	homeobox D13	310					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		CGGCGTATCTCGGCTGCTACG	0.448			T	NUP98	AML*								17	41					0	0	1	0	0	T	176959355	C	T	176959355	3	4	48	1	0	0	0	0	1	0	0	0	7362	893	31	1	935	1	HOXD13	2	176959355	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1294499	176959355	66240018	688	5082										
PDE11A	50940	broad.mit.edu	37	chr2	178740621	178740621	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcactgcactttggggacatCaattcaaaggatttggtaaa	10	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:178740621C>A	ENST00000286063.5	-	5	1649	c.1332G>T	c.(1330-1332)ttG>ttT	p.L444F	PDE11A_ENST00000449286.2_Missense_Mutation_p.L86F|PDE11A_ENST00000389683.3_5'UTR|PDE11A_ENST00000358450.4_Missense_Mutation_p.L194F|PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000409504.1_Missense_Mutation_p.L86F	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	444	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTGGGGACATCAATTCAAAGG	0.388									Primary Pigmented Nodular Adrenocortical Disease, Familial				17	39					2.4624e-09	2.95225e-09	1	1	0	A	178740621	C	A	178740621	3	1	48	1	0	0	0	0	1	0	0	0	11677	825	29	2	1533	2	PDE11A	2	178740621	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1781266	178740621	64458752	689	5083										
PDE11A	50940	broad.mit.edu	37	chr2	178936534	178936534	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaaggtcattggagatatCtttgaccaattccagaaaga	9	7	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:178936534C>A	ENST00000286063.5	-	1	948	c.631G>T	c.(631-633)Gat>Tat	p.D211Y	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	211					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTGGAGATATCTTTGACCAAT	0.478									Primary Pigmented Nodular Adrenocortical Disease, Familial				37	70					7.04047e-22	9.7605e-22	1	1	0	A	178936534	C	A	178936534	3	1	48	1	0	0	0	0	1	0	0	0	11677	913	32	2	2250	2	PDE11A	2	178936534	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	195913	178936534	64262839	690	5084										
OSBPL6	114880	broad.mit.edu	37	chr2	179248854	179248854	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacccagtccttggggagaCttatgaatgcattagagaag	11	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179248854C>A	ENST00000190611.4	+	18	2340	c.1964C>A	c.(1963-1965)aCt>aAt	p.T655N	OSBPL6_ENST00000409045.3_Missense_Mutation_p.T624N|OSBPL6_ENST00000359685.3_Missense_Mutation_p.T619N|OSBPL6_ENST00000409631.1_Missense_Mutation_p.T619N|OSBPL6_ENST00000392505.2_Missense_Mutation_p.T680N|OSBPL6_ENST00000315022.2_Missense_Mutation_p.T659N	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	655					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CTTGGGGAGACTTATGAATGC	0.453													98	215					1.35424e-50	1.96665e-50	1	1	0	A	179248854	C	A	179248854	3	1	48	1	0	0	0	0	1	0	0	0	11327	565	20	5	2148	5	OSBPL6	2	179248854	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	312320	179248854	63950519	691	5085										
OSBPL6	114880	broad.mit.edu	37	chr2	179253834	179253834	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatggagaagtaaccatcaGaaataccaaaagcagtgttt	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179253834G>T	ENST00000190611.4	+	21	2631	c.2255G>T	c.(2254-2256)aGa>aTa	p.R752I	OSBPL6_ENST00000409045.3_Missense_Mutation_p.R721I|OSBPL6_ENST00000359685.3_Missense_Mutation_p.R716I|OSBPL6_ENST00000409631.1_Missense_Mutation_p.R716I|OSBPL6_ENST00000392505.2_Missense_Mutation_p.R777I|OSBPL6_ENST00000315022.2_Missense_Mutation_p.R756I	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	752					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GTAACCATCAGAAATACCAAA	0.353													19	31					1.33834e-09	1.61283e-09	1	1	0	T	179253834	G	T	179253834	3	4	48	1	0	0	0	0	1	0	0	0	11327	942	33	2	2451	2	OSBPL6	2	179253834	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4980	179253834	63945539	692	5086										
PRKRA	8575	broad.mit.edu	37	chr2	179306381	179306381	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatattactaaatttggcaaGaaatttctcagcagcattcc	5	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179306381G>T	ENST00000325748.4	-	6	765	c.565C>A	c.(565-567)Ctt>Att	p.L189I	PRKRA_ENST00000438687.3_Missense_Mutation_p.L76I|PRKRA_ENST00000432031.2_Missense_Mutation_p.L178I|PRKRA_ENST00000487082.1_Missense_Mutation_p.L164I	NM_003690.4	NP_003681.1	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double stranded RNA dependent activator	189	DRBM 2.|Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			AATTTGGCAAGAAATTTCTCA	0.348													8	70					0.000157383	0.000169016	1	1	0	T	179306381	G	T	179306381	3	4	48	1	0	0	0	0	1	0	0	0	12575	942	33	2	388	2	PRKRA	2	179306381	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	52547	179306381	63892992	693	5087										
TTN	7273	broad.mit.edu	37	chr2	179399554	179399554	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaatattatgactgtgtaAaaactgaagtgcttcacaga	7	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179399554A>C	ENST00000589042.1	-	358	102012	c.101788T>G	c.(101788-101790)Tta>Gta	p.L33930V	TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.L25057V|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.L24990V|TTN_ENST00000342992.6_Missense_Mutation_p.L31362V|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.L24865V|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.L32289V|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000589391.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32289							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGACTGTGTAAAAACTGAAGT	0.343													16	40					0	0	1	0	0	C	179399554	A	C	179399554	3	2	48	1	0	0	0	0	1	0	0	0	16796	11	1	4	6211	4	TTN	2	179399554	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	93173	179399554	63799819	694	5088										
TTN	7273	broad.mit.edu	37	chr2	179407401	179407401	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccttaccaagaatgataaCtttaatggtttctgaagtag	7	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179407401C>A	ENST00000589042.1	-	348	97404	c.97180G>T	c.(97180-97182)Gtt>Ttt	p.V32394F	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V23521F|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V23454F|TTN_ENST00000342992.6_Missense_Mutation_p.V29826F|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V23329F|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V30753F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30753	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAATGATAACTTTAATGGTT	0.338													46	94					3.7052e-28	5.25987e-28	1	1	0	A	179407401	C	A	179407401	3	1	48	1	0	0	0	0	1	0	0	0	16796	565	20	5	10859	5	TTN	2	179407401	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7847	179407401	63791972	695	5089										
TTN	7273	broad.mit.edu	37	chr2	179441428	179441428	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcacccatcgcaggcttttCttttctctcctttctacatg	4	15	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179441428C>A	ENST00000589042.1	-	325	69767	c.69543G>T	c.(69541-69543)aaG>aaT	p.K23181N	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K14308N|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K14241N|TTN_ENST00000342992.6_Missense_Mutation_p.K20613N|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K14116N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K21540N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21540	Fibronectin type-III 68.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGGCTTTTCTTTTCTCTCC	0.453													59	100					2.3441e-25	3.30017e-25	1	1	0	A	179441428	C	A	179441428	3	1	48	1	0	0	0	0	1	0	0	0	16796	912	32	2	38588	2	TTN	2	179441428	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34027	179441428	63757945	696	5090										
TTN	7273	broad.mit.edu	37	chr2	179444820	179444820	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcactgtagaccaggatttCctctctgcatcacgtttttg	8	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179444820C>T	ENST00000589042.1	-	318	67418	c.67194G>A	c.(67192-67194)agG>agA	p.R22398R	RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Silent_p.R13525R|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.R13458R|TTN_ENST00000342992.6_Silent_p.R19830R|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Silent_p.R13333R|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Silent_p.R20757R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20757	Ig-like 116.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCAGGATTTCCTCTCTGCAT	0.438													28	50					0	0	1	0	0	T	179444820	C	T	179444820	2	4	48	1	0	0	0	0	0	0	0	1	16796	854	30	3		3	TTN	2	179444820	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3392	179444820	63754553	697	5091										
TTN	7273	broad.mit.edu	37	chr2	179457181	179457181	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaagaataaattccaccatCttcatgggcagcattacgaa	6	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179457181C>T	ENST00000589042.1	-	301	59775	c.59551G>A	c.(59551-59553)Gat>Aat	p.D19851N	TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D10978N|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D10911N|TTN_ENST00000342992.6_Missense_Mutation_p.D17283N|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D10786N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D18210N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18210	Ig-like 110.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCCACCATCTTCATGGGCA	0.373													41	91					0	0	1	0	0	T	179457181	C	T	179457181	3	4	48	1	0	0	0	0	1	0	0	0	16796	913	32	3	48676	3	TTN	2	179457181	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12361	179457181	63742192	698	5092										
TTN	7273	broad.mit.edu	37	chr2	179464378	179464378	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctgcgagactgcggaatAactaaagtgcaagtatcatc	9	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179464378A>G	ENST00000589042.1	-	289	56474	c.56250T>C	c.(56248-56250)gtT>gtC	p.V18750V	TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Silent_p.V9877V|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.V9810V|TTN_ENST00000342992.6_Silent_p.V16182V|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Silent_p.V9685V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Silent_p.V17109V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17109	Fibronectin type-III 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGCGGAATAACTAAAGTGC	0.438													50	89					0	0	1	0	0	G	179464378	A	G	179464378	2	3	48	1	0	0	0	0	0	0	0	1	16796	349	13	4		4	TTN	2	179464378	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7197	179464378	63734995	699	5093										
TTN	7273	broad.mit.edu	37	chr2	179466399	179466399	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttacccatgactttaactCtgcaatttgcagtcttttgt	5	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179466399C>T	ENST00000589042.1	-	286	55642	c.55418G>A	c.(55417-55419)aGa>aAa	p.R18473K	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R9600K|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R9533K|TTN_ENST00000342992.6_Missense_Mutation_p.R15905K|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R9408K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R16832K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16832	Ig-like 106.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTTTAACTCTGCAATTTGC	0.333													19	46					0	0	1	0	0	T	179466399	C	T	179466399	3	4	48	1	0	0	0	0	1	0	0	0	16796	913	32	3	52583	3	TTN	2	179466399	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2021	179466399	63732974	700	5094										
TTN	7273	broad.mit.edu	37	chr2	179471898	179471898	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtctctattggttgtctccAagtatgcatcttggcatctt	8	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179471898A>G	ENST00000589042.1	-	278	53655	c.53431T>C	c.(53431-53433)Tgg>Cgg	p.W17811R	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.W8938R|TTN_ENST00000359218.5_Missense_Mutation_p.W8871R|TTN_ENST00000342992.6_Missense_Mutation_p.W15243R|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.W8746R|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.W16170R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16170	Ig-like 104.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTGTCTCCAAGTATGCATC	0.393													4	115					0	0	1	0	0	G	179471898	A	G	179471898	3	3	48	1	0	0	0	0	1	0	0	0	16796	130	5	4	54602	4	TTN	2	179471898	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5499	179471898	63727475	701	5095										
TTN	7273	broad.mit.edu	37	chr2	179478500	179478500	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatgttgtgtcctttactgGcatcttattgcatctaaccc	7	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179478500G>A	ENST00000589042.1	-	263	49734	c.49510C>T	c.(49510-49512)Cca>Tca	p.P16504S	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P7631S|TTN_ENST00000359218.5_Missense_Mutation_p.P7564S|TTN_ENST00000342992.6_Missense_Mutation_p.P13936S|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P7439S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P14863S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14863	Fibronectin type-III 19.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTTACTGGCATCTTATTG	0.413													36	81					0	0	1	0	0	A	179478500	G	A	179478500	3	1	48	1	0	0	0	0	1	0	0	0	16796	1203	42	3	58583	3	TTN	2	179478500	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6602	179478500	63720873	702	5096										
TTN	7273	broad.mit.edu	37	chr2	179498763	179498763	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagttgctgtttcaccttCttttactgtttgatcttcaa	5	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179498763C>A	ENST00000589042.1	-	231	42687	c.42463G>T	c.(42463-42465)Gaa>Taa	p.E14155*	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.E5282*|TTN_ENST00000359218.5_Nonsense_Mutation_p.E5215*|TTN_ENST00000342992.6_Nonsense_Mutation_p.E11587*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.E5090*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.E12514*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12514	Fibronectin type-III 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCACCTTCTTTTACTGTT	0.358													27	58					3.01185e-09	3.60563e-09	1	1	0	A	179498763	C	A	179498763	4	1	48	1	0	0	0	0	0	1	0	0	16796	922	32	2	65758	2	TTN	2	179498763	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	20263	179498763	63700610	703	5097										
TTN	7273	broad.mit.edu	37	chr2	179517234	179517234	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaggagccgctggcactttCttttcaggaacaacttcttt	10	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179517234C>A	ENST00000589042.1	-	202	39302	c.39078G>T	c.(39076-39078)aaG>aaT	p.K13026N	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.K10592N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K11519N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11380	Ig-like 86.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGCACTTTCTTTTCAGGAA	0.378													49	103					4.86159e-25	6.8376e-25	1	1	0	A	179517234	C	A	179517234	3	1	48	1	0	0	0	0	1	0	0	0	16796	912	32	2	68837	2	TTN	2	179517234	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18471	179517234	63682139	704	5098										
TTN	7273	broad.mit.edu	37	chr2	179542573	179542573	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctcttcaggaacaatttCttcttcaaatagaacttcct	3	11	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179542573C>A	ENST00000589042.1	-	146	34290	c.34066G>T	c.(34066-34068)Gaa>Taa	p.E11356*	TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Nonsense_Mutation_p.E10112*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.E11039*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11039	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E10112*(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAACAATTTCTTCTTCAAAT	0.408													36	60					2.09667e-21	2.89385e-21	1	1	0	A	179542573	C	A	179542573	4	1	48	1	0	0	0	0	0	1	0	0	16796	922	32	2	70331	2	TTN	2	179542573	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	25339	179542573	63656800	705	5099										
TTN	7273	broad.mit.edu	37	chr2	179565931	179565931	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaaccacaggagggatttCtgaagaaaataaatgccgtt	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179565931C>T	ENST00000589042.1	-	111	30823		c.e111-1		TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Splice_Site|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Splice_Site	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAGGGATTTCTGAAGAAAAT	0.363													30	61					0	0	1	0	0	T	179565931	C	T	179565931	5	4	48	1	0	0	0	0	0	0	1	0	16796	927	32	3	73939	3	TTN	2	179565931	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23358	179565931	63633442	706	5100										
TTN	7273	broad.mit.edu	37	chr2	179568878	179568878	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagtgtttcacgcaccttcGattctgagttctgctgaagt	9	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179568878G>A	ENST00000589042.1	-	106	30443	c.30219C>T	c.(30217-30219)atC>atT	p.I10073I	TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.I8829I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Silent_p.I9756I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9756	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACGCACCTTCGATTCTGAGTT	0.468													6	117					0	0	1	0	0	A	179568878	G	A	179568878	2	1	48	1	0	0	0	0	0	0	0	1	16796	1048	37	1		1	TTN	2	179568878	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2947	179568878	63630495	707	5101										
TTN	7273	broad.mit.edu	37	chr2	179571456	179571456	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaacttttgcaatgaaggtCgcagtggtttctaaggaata	10	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179571456C>T	ENST00000589042.1	-	102	29369	c.29145G>A	c.(29143-29145)gcG>gcA	p.A9715A	TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.A8471A|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Silent_p.A9398A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9398	Ig-like 78.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATGAAGGTCGCAGTGGTTT	0.353													23	34					0	0	1	0	0	T	179571456	C	T	179571456	2	4	48	1	0	0	0	0	0	0	0	1	16796	871	31	1		1	TTN	2	179571456	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2578	179571456	63627917	708	5102										
TTN	7273	broad.mit.edu	37	chr2	179584511	179584511	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actctaatgcaaaaggatttCcagtagtgacagtcatgggt	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179584511C>T	ENST00000589042.1	-	82	23932	c.23708G>A	c.(23707-23709)gGa>gAa	p.G7903E	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G6659E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G7586E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7586	Ig-like 61.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAAGGATTTCCAGTAGTGAC	0.408													10	18					0	0	1	0	0	T	179584511	C	T	179584511	3	4	48	1	0	0	0	0	1	0	0	0	16796	855	30	3	80945	3	TTN	2	179584511	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13055	179584511	63614862	709	5103										
TTN	7273	broad.mit.edu	37	chr2	179585127	179585127	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaacctttgaacttgacagAgcaagaacacgtgtcacttc	7	11	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179585127A>G	ENST00000589042.1	-	80	23586	c.23362T>C	c.(23362-23364)Tct>Cct	p.S7788P	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.S6544P|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S7471P	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7471	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTTGACAGAGCAAGAACAC	0.408													19	53					0	0	1	0	0	G	179585127	A	G	179585127	3	3	48	1	0	0	0	0	1	0	0	0	16796	304	11	4	81299	4	TTN	2	179585127	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	616	179585127	63614246	710	5104										
TTN	7273	broad.mit.edu	37	chr2	179588843	179588843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccagtatttttcagtcttCgtgtgaaagagggaggaact	11	7	2	2	rs148072021	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179588843C>T	ENST00000589042.1	-	73	21367	c.21143G>A	c.(21142-21144)cGa>cAa	p.R7048Q	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.R5804Q|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R6731Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6731	Ig-like 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R5804L(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGTCTTCGTGTGAAAGA	0.418													9	15					0	0	1	0	0	T	179588843	C	T	179588843	3	4	48	1	0	0	0	0	1	0	0	0	16796	884	31	1	83546	1	TTN	2	179588843	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3716	179588843	63610530	711	5105										
TTN	7273	broad.mit.edu	37	chr2	179592343	179592343	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatcgtagtacaagagtcGctaccaacatcattggtaac	7	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179592343G>A	ENST00000589042.1	-	68	20186	c.19962C>T	c.(19960-19962)agC>agT	p.S6654S	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.S5410S|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Silent_p.S6337S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6337	Ig-like 48.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAAGAGTCGCTACCAACAT	0.413													52	156					0	0	1	0	0	A	179592343	G	A	179592343	2	1	48	1	0	0	0	0	0	0	0	1	16796	1078	38	1		1	TTN	2	179592343	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3500	179592343	63607030	712	5106										
TTN	7273	broad.mit.edu	37	chr2	179594290	179594290	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctctctgataaaggtggggGgttctaaagattcaaaagga	13	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179594290G>A	ENST00000589042.1	-	64	18817	c.18593C>T	c.(18592-18594)cCc>cTc	p.P6198L	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.P4954L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P5881L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5881	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGGTGGGGGGTTCTAAAGA	0.458													22	50					0	0	1	0	0	A	179594290	G	A	179594290	3	1	48	1	0	0	0	0	1	0	0	0	16796	1232	43	3	86132	3	TTN	2	179594290	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1947	179594290	63605083	713	5107										
TTN	7273	broad.mit.edu	37	chr2	179595004	179595004	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttaaaccactttattgtCatgggtgcagtgccacccac	7	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179595004C>A	ENST00000589042.1	-	62	18347	c.18123G>T	c.(18121-18123)atG>atT	p.M6041I	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.M4797I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.M5724I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5724	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTTATTGTCATGGGTGCAG	0.478													7	18					8.12818e-05	8.79784e-05	1	1	0	A	179595004	C	A	179595004	3	1	48	1	0	0	0	0	1	0	0	0	16796	826	29	2	86610	2	TTN	2	179595004	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	714	179595004	63604369	714	5108										
TTN	7273	broad.mit.edu	37	chr2	179596285	179596285	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggagggagctggtactctcGatcttctttatgaaggatgg	14	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179596285G>A	ENST00000589042.1	-	59	17432	c.17208C>T	c.(17206-17208)atC>atT	p.I5736I	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.I4492I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Silent_p.I5419I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5419	Ig-like 38.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTACTCTCGATCTTCTTTA	0.448													9	30					0	0	1	0	0	A	179596285	G	A	179596285	2	1	48	1	0	0	0	0	0	0	0	1	16796	1048	37	1		1	TTN	2	179596285	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1281	179596285	63603088	715	5109										
TTN	7273	broad.mit.edu	37	chr2	179596486	179596486	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcacccgacactggtattCgccagcatctgcagctacaa	9	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179596486C>T	ENST00000589042.1	-	58	17340	c.17116G>A	c.(17116-17118)Gaa>Aaa	p.E5706K	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E4462K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E5389K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5389	Ig-like 38.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E4462K(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGGTATTCGCCAGCATCT	0.488													41	85					0	0	1	0	0	T	179596486	C	T	179596486	3	4	48	1	0	0	0	0	1	0	0	0	16796	893	31	1	87633	1	TTN	2	179596486	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	201	179596486	63602887	716	5110										
TTN	7273	broad.mit.edu	37	chr2	179600640	179600640	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgtgtttgttttctgcgtCggaaatcctccagttaggtg	11	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179600640C>T	ENST00000589042.1	-	50	14757	c.14533G>A	c.(14533-14535)Gac>Aac	p.D4845N	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.D3601N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D4528N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4528	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D3601N(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCTGCGTCGGAAATCCTC	0.438													17	46					0	0	1	0	0	T	179600640	C	T	179600640	3	4	48	1	0	0	0	0	1	0	0	0	16796	884	31	1	90248	1	TTN	2	179600640	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4154	179600640	63598733	717	5111										
TTN	7273	broad.mit.edu	37	chr2	179604701	179604701	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctccaccttttcaatatttCttagccactcagagaaaaga	4	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179604701C>A	ENST00000589042.1	-	48	13483	c.13259G>T	c.(13258-13260)aGa>aTa	p.R4420I	TTN_ENST00000342175.6_Missense_Mutation_p.R4249I|TTN_ENST00000359218.5_Missense_Mutation_p.R4182I|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R4057I|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R4103I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4103	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R4249I(1)|p.R4182I(1)|p.R4057I(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAATATTTCTTAGCCACTC	0.473													34	47					9.17885e-22	1.27125e-21	1	1	0	A	179604701	C	A	179604701	3	1	48	1	0	0	0	0	1	0	0	0	16796	913	32	2	91530	2	TTN	2	179604701	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4061	179604701	63594672	718	5112										
TTN	7273	broad.mit.edu	37	chr2	179605938	179605938	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctgctttacagatatagaGgccactgtcttccctctgag	8	12	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179605938G>A	ENST00000589042.1	-	48	12246	c.12022C>T	c.(12022-12024)Ctc>Ttc	p.L4008F	TTN_ENST00000342175.6_Missense_Mutation_p.L3837F|TTN_ENST00000359218.5_Missense_Mutation_p.L3770F|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.L3645F|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.L3691F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3691							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGATATAGAGGCCACTGTCT	0.458													27	62					0	0	1	0	0	A	179605938	G	A	179605938	3	1	48	1	0	0	0	0	1	0	0	0	16796	1000	35	3	92767	3	TTN	2	179605938	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1237	179605938	63593435	719	5113										
TTN	7273	broad.mit.edu	37	chr2	179613073	179613073	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttttctccaccatagttCtatttgaaagctcttgactg	5	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179613073C>T	ENST00000360870.5	-	46	14276	c.14054G>A	c.(14053-14055)aGa>aAa	p.R4685K	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	800	Ig-like 27.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCATAGTTCTATTTGAAAG	0.328													26	46					0	0	1	0	0	T	179613073	C	T	179613073	3	4	48	1	0	0	0	0	1	0	0	0	16796	913	32	3	96243	3	TTN	2	179613073	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7135	179613073	63586300	720	5114										
TTN	7273	broad.mit.edu	37	chr2	179629268	179629268	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctaccttccactgagagtGaagctgatgttgtggcaaca	10	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179629268G>T	ENST00000589042.1	-	42	10198	c.9974C>A	c.(9973-9975)tCa>tAa	p.S3325*	TTN_ENST00000342175.6_Nonsense_Mutation_p.S3279*|TTN_ENST00000359218.5_Nonsense_Mutation_p.S3279*|TTN_ENST00000342992.6_Nonsense_Mutation_p.S3325*|TTN_ENST00000360870.5_Nonsense_Mutation_p.S3325*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.S3279*|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.S3325*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3050	Ig-like 19.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGAGAGTGAAGCTGATGT	0.433													34	71					7.11191e-15	9.30872e-15	1	1	0	T	179629268	G	T	179629268	4	4	48	1	0	0	0	0	0	1	0	0	16796	1294	45	2	101298	2	TTN	2	179629268	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16195	179629268	63570105	721	5115										
TTN	7273	broad.mit.edu	37	chr2	179631267	179631267	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaattgatttcaatgccatCtttataccagtgggcatcaa	7	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179631267C>A	ENST00000589042.1	-	41	9768	c.9544G>T	c.(9544-9546)Gat>Tat	p.D3182Y	TTN_ENST00000342175.6_Missense_Mutation_p.D3136Y|TTN_ENST00000359218.5_Missense_Mutation_p.D3136Y|TTN_ENST00000342992.6_Missense_Mutation_p.D3182Y|TTN_ENST00000360870.5_Missense_Mutation_p.D3182Y|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D3136Y|TTN_ENST00000591111.1_Missense_Mutation_p.D3182Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2917							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAATGCCATCTTTATACCAG	0.393													20	26					2.94398e-08	3.45884e-08	1	1	0	A	179631267	C	A	179631267	3	1	48	1	0	0	0	0	1	0	0	0	16796	913	32	2	101732	2	TTN	2	179631267	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1999	179631267	63568106	722	5116										
TTN	7273	broad.mit.edu	37	chr2	179639177	179639177	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacttctatgtcctgaagttCtttcacaaactcaacaactg	4	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179639177C>A	ENST00000589042.1	-	30	7038	c.6814G>T	c.(6814-6816)Gaa>Taa	p.E2272*	TTN_ENST00000342175.6_Nonsense_Mutation_p.E2226*|TTN_ENST00000359218.5_Nonsense_Mutation_p.E2226*|TTN_ENST00000342992.6_Nonsense_Mutation_p.E2272*|TTN_ENST00000360870.5_Nonsense_Mutation_p.E2272*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.E2226*|TTN-AS1_ENST00000584485.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.E2272*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1996	Ig-like 12.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTGAAGTTCTTTCACAAAC	0.348													13	18					0.000151284	0.00016287	1	1	0	A	179639177	C	A	179639177	4	1	48	1	0	0	0	0	0	1	0	0	16796	922	32	2	104506	2	TTN	2	179639177	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7910	179639177	63560196	723	5117										
TTN	7273	broad.mit.edu	37	chr2	179640269	179640269	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttttgtaccattcacattCggggtctggtttccccacga	8	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179640269C>T	ENST00000589042.1	-	28	6546	c.6322G>A	c.(6322-6324)Gaa>Aaa	p.E2108K	TTN_ENST00000342175.6_Missense_Mutation_p.E2062K|TTN_ENST00000359218.5_Missense_Mutation_p.E2062K|TTN_ENST00000342992.6_Missense_Mutation_p.E2108K|TTN_ENST00000360870.5_Missense_Mutation_p.E2108K|TTN_ENST00000460472.2_Missense_Mutation_p.E2062K|TTN_ENST00000591111.1_Missense_Mutation_p.E2108K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1871	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTCACATTCGGGGTCTGGT	0.473													23	31					0	0	1	0	0	T	179640269	C	T	179640269	3	4	48	1	0	0	0	0	1	0	0	0	16796	893	31	1	105006	1	TTN	2	179640269	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1092	179640269	63559104	724	5118										
TTN	7273	broad.mit.edu	37	chr2	179645959	179645959	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaatcaccagcttgcattCaccggtttgtttgttgtaac	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179645959C>A	ENST00000589042.1	-	21	3636	c.3412G>T	c.(3412-3414)Gaa>Taa	p.E1138*	TTN_ENST00000342175.6_Nonsense_Mutation_p.E1092*|TTN_ENST00000359218.5_Nonsense_Mutation_p.E1092*|TTN_ENST00000342992.6_Nonsense_Mutation_p.E1138*|TTN_ENST00000360870.5_Nonsense_Mutation_p.E1138*|TTN_ENST00000460472.2_Nonsense_Mutation_p.E1092*|TTN_ENST00000591111.1_Nonsense_Mutation_p.E1138*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1138	Ig-like 4.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTTGCATTCACCGGTTTGT	0.348													7	28					1.26484e-09	1.52852e-09	1	1	0	A	179645959	C	A	179645959	4	1	48	1	0	0	0	0	0	1	0	0	16796	835	29	2	107944	2	TTN	2	179645959	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5690	179645959	63553414	725	5119										
TTN	7273	broad.mit.edu	37	chr2	179654773	179654773	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctacctcttgatactaaatCttgttctttgactttgggtg	7	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179654773C>T	ENST00000589042.1	-	12	2094	c.1870G>A	c.(1870-1872)Gat>Aat	p.D624N	TTN_ENST00000342175.6_Missense_Mutation_p.D578N|TTN_ENST00000359218.5_Missense_Mutation_p.D578N|TTN_ENST00000342992.6_Missense_Mutation_p.D624N|TTN_ENST00000360870.5_Missense_Mutation_p.D624N|TTN_ENST00000460472.2_Missense_Mutation_p.D578N|TTN_ENST00000591111.1_Missense_Mutation_p.D624N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	624							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATACTAAATCTTGTTCTTTG	0.348													27	39					0	0	1	0	0	T	179654773	C	T	179654773	3	4	48	1	0	0	0	0	1	0	0	0	16796	913	32	3	109522	3	TTN	2	179654773	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8814	179654773	63544600	726	5120										
TTN	7273	broad.mit.edu	37	chr2	179664562	179664562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaaaataccttttcaattCgggtttgtcttgattctgag	8	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:179664562C>T	ENST00000589042.1	-	5	883	c.659G>A	c.(658-660)cGa>cAa	p.R220Q	TTN_ENST00000342175.6_Missense_Mutation_p.R220Q|TTN_ENST00000359218.5_Missense_Mutation_p.R220Q|TTN_ENST00000342992.6_Missense_Mutation_p.R220Q|TTN_ENST00000360870.5_Missense_Mutation_p.R220Q|TTN_ENST00000460472.2_Missense_Mutation_p.R220Q|TTN_ENST00000591111.1_Missense_Mutation_p.R220Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	220							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R220P(6)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTCAATTCGGGTTTGTCT	0.403													18	31					0	0	1	0	0	T	179664562	C	T	179664562	3	4	48	1	0	0	0	0	1	0	0	0	16796	884	31	1	110761	1	TTN	2	179664562	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9789	179664562	63534811	727	5121										
CWC22	57703	broad.mit.edu	37	chr2	180835565	180835565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagactcatgcagaatgtttCgaaggcgttcaaatatagct	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:180835565C>T	ENST00000410053.3	-	10	1258	c.959G>A	c.(958-960)cGa>cAa	p.R320Q	CWC22_ENST00000295749.6_Missense_Mutation_p.R320Q	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	320	MIF4G.					catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						CAGAATGTTTCGAAGGCGTTC	0.308													24	41					0	0	1	0	0	T	180835565	C	T	180835565	3	4	48	1	0	0	0	0	1	0	0	0	4091	884	31	1	1811	1	CWC22	2	180835565	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1171003	180835565	62363808	728	5122										
CWC22	57703	broad.mit.edu	37	chr2	180838374	180838374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatataccttgtcatttcttCgatagccttttcgaaaatta	4	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:180838374C>T	ENST00000410053.3	-	7	1036	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	CWC22_ENST00000295749.6_Missense_Mutation_p.R246Q	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	246	MIF4G.					catalytic step 2 spliceosome	protein binding|RNA binding	p.R246Q(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						GTCATTTCTTCGATAGCCTTT	0.313													8	14					0	0	1	0	0	T	180838374	C	T	180838374	3	4	48	1	0	0	0	0	1	0	0	0	4091	884	31	1	2045	1	CWC22	2	180838374	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2809	180838374	62360999	729	5123										
ITGA4	3676	broad.mit.edu	37	chr2	182339888	182339888	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttttattttattcagacTtgtgggcatagatggaaaaa	8	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:182339888T>G	ENST00000397033.2	+	4	859	c.429T>G	c.(427-429)acT>acG	p.T143T	ITGA4_ENST00000478440.1_Intron|ITGA4_ENST00000339307.4_Silent_p.T143T	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	143					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TTATTCAGACTTGTGGGCATA	0.408													9	48					0	0	1	0	0	G	182339888	T	G	182339888	2	3	48	1	0	0	0	0	0	0	0	1	7921	1596	56	4		4	ITGA4	2	182339888	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1501514	182339888	60859485	730	5124										
ITGA4	3676	broad.mit.edu	37	chr2	182339943	182339943	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaatgaaaataagctccccActggtggttgctatggagtg	12	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:182339943A>G	ENST00000397033.2	+	4	914	c.484A>G	c.(484-486)Act>Gct	p.T162A	ITGA4_ENST00000478440.1_Intron|ITGA4_ENST00000339307.4_Missense_Mutation_p.T162A	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	162					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TAAGCTCCCCACTGGTGGTTG	0.373													29	49					0	0	1	0	0	G	182339943	A	G	182339943	3	3	48	1	0	0	0	0	1	0	0	0	7921	159	6	4	498	4	ITGA4	2	182339943	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	55	182339943	60859430	731	5125										
ITGA4	3676	broad.mit.edu	37	chr2	182350655	182350655	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacctcgttggaagtgacaaAtatgctgcaagatttgggga	12	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:182350655A>G	ENST00000397033.2	+	10	1519	c.1089A>G	c.(1087-1089)aaA>aaG	p.K363K		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	363					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity	p.K363N(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAAGTGACAAATATGCTGCAA	0.368													27	44					0	0	1	0	0	G	182350655	A	G	182350655	2	3	48	1	0	0	0	0	0	0	0	1	7921	98	4	4		4	ITGA4	2	182350655	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	10712	182350655	60848718	732	5126										
ITGA4	3676	broad.mit.edu	37	chr2	182350666	182350666	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtgacaaatatgctgcaaGatttggggaatctatagtta	10	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:182350666G>A	ENST00000397033.2	+	10	1530	c.1100G>A	c.(1099-1101)aGa>aAa	p.R367K		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	367					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TATGCTGCAAGATTTGGGGAA	0.363													26	48					0	0	1	0	0	A	182350666	G	A	182350666	3	1	48	1	0	0	0	0	1	0	0	0	7921	942	33	3	1138	3	ITGA4	2	182350666	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11	182350666	60848707	733	5127										
CERKL	0	broad.mit.edu	37	chr2	182412416	182412416	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccataatgctgacattcaaGaactgaccctggatcatttg	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:182412416G>A	ENST00000410087.3	-	10	1297	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	CERKL_ENST00000339098.5_Silent_p.F425F|CERKL_ENST00000374969.2_Silent_p.F286F|CERKL_ENST00000374970.2_Silent_p.F330F|CERKL_ENST00000479558.1_5'UTR|CERKL_ENST00000409440.3_Silent_p.F381F	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	425					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TGACATTCAAGAACTGACCCT	0.403													47	90					0	0	1	0	0	A	182412416	G	A	182412416	2	1	48	1	0	0	0	0	0	0	0	1	3290	933	33	3		3	CERKL	2	182412416	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	61750	182412416	60786957	734	5128										
SSFA2	6744	broad.mit.edu	37	chr2	182767184	182767184	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcagaaggactccttcgaAatggaagaggtaggtaaaaa	12	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:182767184A>C	ENST00000431877.2	+	8	1583	c.1404A>C	c.(1402-1404)gaA>gaC	p.E468D	SSFA2_ENST00000320370.7_Missense_Mutation_p.E468D|SSFA2_ENST00000428267.2_Missense_Mutation_p.E315D|SSFA2_ENST00000409001.1_Missense_Mutation_p.E468D	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	468						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ACTCCTTCGAAATGGAAGAGG	0.368													27	34					0	0	1	0	0	C	182767184	A	C	182767184	3	2	48	1	0	0	0	0	1	0	0	0	15238	11	1	4	1434	4	SSFA2	2	182767184	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	354768	182767184	60432189	735	5129										
PDE1A	0	broad.mit.edu	37	chr2	183051307	183051307	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttggctctactatgaaatCgatgaaacctacaaaagcca	7	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:183051307C>T	ENST00000435564.1	-	12	1464	c.1264G>A	c.(1264-1266)Gat>Aat	p.D422N	PDE1A_ENST00000351439.5_Missense_Mutation_p.D406N|PDE1A_ENST00000346717.4_Missense_Mutation_p.D388N|PDE1A_ENST00000536095.1_Missense_Mutation_p.D318N|PDE1A_ENST00000456212.1_Missense_Mutation_p.D422N|PDE1A_ENST00000410103.1_Missense_Mutation_p.D422N|PDE1A_ENST00000409365.1_Missense_Mutation_p.D406N|PDE1A_ENST00000358139.2_Missense_Mutation_p.D422N|PDE1A_ENST00000331935.6_Missense_Mutation_p.D422N	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	422	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.D422N(2)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ACTATGAAATCGATGAAACCT	0.353													7	34					0	0	1	0	0	T	183051307	C	T	183051307	3	4	48	1	0	0	0	0	1	0	0	0	11679	884	31	1	433	1	PDE1A	2	183051307	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	284123	183051307	60148066	736	5130										
PDE1A	0	broad.mit.edu	37	chr2	183070763	183070763	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgattctcaaggacagagCgatcattatacaaaatggca	10	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:183070763C>T	ENST00000435564.1	-	8	1054	c.854G>A	c.(853-855)cGc>cAc	p.R285H	PDE1A_ENST00000351439.5_Missense_Mutation_p.R269H|PDE1A_ENST00000346717.4_Missense_Mutation_p.R251H|PDE1A_ENST00000536095.1_Missense_Mutation_p.R181H|PDE1A_ENST00000456212.1_Missense_Mutation_p.R285H|PDE1A_ENST00000410103.1_Missense_Mutation_p.R285H|PDE1A_ENST00000409365.1_Missense_Mutation_p.R269H|PDE1A_ENST00000358139.2_Missense_Mutation_p.R285H|PDE1A_ENST00000331935.6_Missense_Mutation_p.R285H	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	285	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AAGGACAGAGCGATCATTATA	0.358													14	22					0	0	1	0	0	T	183070763	C	T	183070763	3	4	48	1	0	0	0	0	1	0	0	0	11679	768	27	1	859	1	PDE1A	2	183070763	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19456	183070763	60128610	737	5131										
DNAJC10	54431	broad.mit.edu	37	chr2	183621136	183621136	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagtctggatggttgatttCtattctccgtggtgtcatcc	11	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:183621136C>A	ENST00000264065.6	+	18	2164	c.1749C>A	c.(1747-1749)ttC>ttA	p.F583L		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	583	Thioredoxin 3.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGGTTGATTTCTATTCTCCGT	0.388													9	41					3.09899e-07	3.54467e-07	1	1	0	A	183621136	C	A	183621136	3	1	48	1	0	0	0	0	1	0	0	0	4656	912	32	2	1811	2	DNAJC10	2	183621136	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	550373	183621136	59578237	738	5132										
DNAJC10	54431	broad.mit.edu	37	chr2	183621186	183621186	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttaatgccagaatggaaaaGaatggcccgggtatagtaaa	11	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:183621186G>T	ENST00000264065.6	+	18	2214	c.1799G>T	c.(1798-1800)aGa>aTa	p.R600I		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	600	Thioredoxin 3.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GAATGGAAAAGAATGGCCCGG	0.338													21	31					4.35082e-09	5.20082e-09	1	1	0	T	183621186	G	T	183621186	3	4	48	1	0	0	0	0	1	0	0	0	4656	942	33	2	1861	2	DNAJC10	2	183621186	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	50	183621186	59578187	739	5133										
NCKAP1	10787	broad.mit.edu	37	chr2	183821229	183821229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgagaagtcaaatattctCgtggggtaaaggtatgttcc	12	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:183821229C>T	ENST00000360982.2	-	21	2890	c.2132G>A	c.(2131-2133)cGa>cAa	p.R711Q	NCKAP1_ENST00000361354.3_Missense_Mutation_p.R705Q	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	705					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CAAATATTCTCGTGGGGTAAA	0.333													25	36					0	0	1	0	0	T	183821229	C	T	183821229	3	4	48	1	0	0	0	0	1	0	0	0	10267	884	31	1	1320	1	NCKAP1	2	183821229	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	200043	183821229	59378144	740	5134										
NCKAP1	10787	broad.mit.edu	37	chr2	183845983	183845983	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtttttacctgcacgagttCattgaggacaacagcatcaa	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:183845983C>A	ENST00000360982.2	-	14	2106	c.1348G>T	c.(1348-1350)Gaa>Taa	p.E450*	NCKAP1_ENST00000361354.3_Nonsense_Mutation_p.E444*	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	444					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGCACGAGTTCATTGAGGACA	0.383													23	39					3.62473e-10	4.42315e-10	1	1	0	A	183845983	C	A	183845983	4	1	48	1	0	0	0	0	0	1	0	0	10267	835	29	2	2132	2	NCKAP1	2	183845983	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	24754	183845983	59353390	741	5135										
ZNF804A	91752	broad.mit.edu	37	chr2	185798421	185798421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaggaaaaggcactccaacGcctgcacaagctggctgagc	11	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:185798421G>A	ENST00000302277.6	+	3	941	c.347G>A	c.(346-348)cGc>cAc	p.R116H		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	116						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GCACTCCAACGCCTGCACAAG	0.403													15	24					0	0	1	0	0	A	185798421	G	A	185798421	3	1	48	1	0	0	0	0	1	0	0	0	18218	1087	38	1	357	1	ZNF804A	2	185798421	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1952438	185798421	57400952	742	5136										
FSIP2	401024	broad.mit.edu	37	chr2	186672466	186672466	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taactccacatcagtgtgtgGaagttgaaaacatcgttgaa	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:186672466G>A	ENST00000343098.5	+	17	18700	c.18700G>A	c.(18700-18702)Gaa>Aaa	p.E6234K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6145K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TCAGTGTGTGGAAGTTGAAAA	0.398													8	54					0	0	1	0	0	A	186672466	G	A	186672466	3	1	48	1	0	0	0	0	1	0	0	0	6109	1175	41	3	18766	3	FSIP2	2	186672466	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	874045	186672466	56526907	743	5137										
ITGAV	3685	broad.mit.edu	37	chr2	187516777	187516777	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattttaaatcaagacaataAaacctgctcactgcctggaa	5	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:187516777A>C	ENST00000261023.3	+	15	1740	c.1466A>C	c.(1465-1467)aAa>aCa	p.K489T	AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000433736.2_Missense_Mutation_p.K443T|ITGAV_ENST00000374907.3_Missense_Mutation_p.K453T	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	489					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		CAAGACAATAAAACCTGCTCA	0.388													4	11					0	0	1	0	0	C	187516777	A	C	187516777	3	2	48	1	0	0	0	0	1	0	0	0	7931	14	1	4	1575	4	ITGAV	2	187516777	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	844311	187516777	55682596	744	5138										
ZSWIM2	151112	broad.mit.edu	37	chr2	187702145	187702145	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtttgctagagtttttgaAttcctccaaaatcagtttta	6	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:187702145A>C	ENST00000295131.2	-	5	670	c.631T>G	c.(631-633)Ttc>Gtc	p.F211V		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	211					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GAGTTTTTGAATTCCTCCAAA	0.393													25	39					0	0	1	0	0	C	187702145	A	C	187702145	3	2	48	1	0	0	0	0	1	0	0	0	18280	101	4	4	1290	4	ZSWIM2	2	187702145	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	185368	187702145	55497228	745	5139										
TFPI	7035	broad.mit.edu	37	chr2	188331683	188331683	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacatatttttaacaaaaaTttcttcatatgctattttca	1	7	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:188331683T>G	ENST00000233156.3	-	8	1189	c.895A>C	c.(895-897)Att>Ctt	p.I299L	TFPI_ENST00000392365.1_Missense_Mutation_p.I299L|AC007319.1_ENST00000453517.1_RNA|AC007319.1_ENST00000412276.1_RNA	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	299					blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	TTAACAAAAATTTCTTCATAT	0.249													8	15					0	0	1	0	0	G	188331683	T	G	188331683	3	3	48	1	0	0	0	0	1	0	0	0	15867	1493	52	4	23	4	TFPI	2	188331683	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	629538	188331683	54867690	746	5140										
TFPI	7035	broad.mit.edu	37	chr2	188343453	188343453	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagaaagaacatggatgcatGaatgcagaaggcgttcagaa	12	5	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:188343453G>T	ENST00000409676.1	-	8	970	c.706C>A	c.(706-708)Cat>Aat	p.H236N	TFPI_ENST00000392365.1_Intron|AC007319.1_ENST00000453517.1_RNA|AC007319.1_ENST00000412276.1_RNA|TFPI_ENST00000339091.4_Missense_Mutation_p.H236N|TFPI_ENST00000233156.3_Intron			P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0	BPTI/Kunitz inhibitor 3.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	ATGGATGCATGAATGCAGAAG	0.353													11	16					0.0692343	0.0701576	1	1	0	T	188343453	G	T	188343453	3	4	48	1	0	0	0	0	1	0	0	0	15867	1290	45	2	348	2	TFPI	2	188343453	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11770	188343453	54855920	747	5141										
TFPI	7035	broad.mit.edu	37	chr2	188361697	188361697	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atataaattcttcgcactgtCgagtgaaaatattgaagaaa	7	5	1	3	rs137865208		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:188361697C>T	ENST00000233156.3	-	3	524	c.230G>A	c.(229-231)cGa>cAa	p.R77Q	TFPI_ENST00000392365.1_Missense_Mutation_p.R77Q|TFPI_ENST00000409676.1_Missense_Mutation_p.R77Q|AC007319.1_ENST00000453517.1_RNA|AC007319.1_ENST00000412276.1_RNA|TFPI_ENST00000339091.4_Missense_Mutation_p.R77Q	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	77	BPTI/Kunitz inhibitor 1.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	TTCGCACTGTCGAGTGAAAAT	0.378													16	36					0	0	1	0	0	T	188361697	C	T	188361697	3	4	48	1	0	0	0	0	1	0	0	0	15867	884	31	1	840	1	TFPI	2	188361697	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18244	188361697	54837676	748	5142										
GULP1	51454	broad.mit.edu	37	chr2	189452618	189452618	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagaaccttttgacccatTtaactgtggagcagcagatt	9	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:189452618T>G	ENST00000409580.1	+	12	1499	c.785T>G	c.(784-786)tTt>tGt	p.F262C	GULP1_ENST00000409609.1_Missense_Mutation_p.F262C|GULP1_ENST00000409830.1_Missense_Mutation_p.F262C|GULP1_ENST00000409843.1_Missense_Mutation_p.F262C|GULP1_ENST00000359135.3_Missense_Mutation_p.F262C|GULP1_ENST00000409805.1_Missense_Mutation_p.F159C			Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing 1	262					apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			TTTGACCCATTTAACTGTGGA	0.368													17	36					0	0	1	0	0	G	189452618	T	G	189452618	3	3	48	1	0	0	0	0	1	0	0	0	6941	1841	64	4	819	4	GULP1	2	189452618	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1090921	189452618	53746755	749	5143										
ANKAR	150709	broad.mit.edu	37	chr2	190554573	190554573	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacactttgagaagaaaaaaGatatcagaagagggatagga	11	3	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:190554573G>T	ENST00000520309.1	+	3	1010	c.922G>T	c.(922-924)Gat>Tat	p.D308Y	ANKAR_ENST00000438402.2_Missense_Mutation_p.D308Y|ANKAR_ENST00000313581.4_Missense_Mutation_p.D308Y|ANKAR_ENST00000281412.6_Missense_Mutation_p.D72Y|ANKAR_ENST00000431575.2_Missense_Mutation_p.D237Y|ANKAR_ENST00000461516.1_3'UTR	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	308						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GAAGAAAAAAGATATCAGAAG	0.284													23	42					3.5997e-14	4.67138e-14	1	1	0	T	190554573	G	T	190554573	3	4	48	1	0	0	0	0	1	0	0	0	619	942	33	2	928	2	ANKAR	2	190554573	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1101955	190554573	52644800	750	5144										
MSTN	2660	broad.mit.edu	37	chr2	190922365	190922365	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgacctctaaaaacggattCtgtttgaaaaggaaagaaca	8	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:190922365C>T	ENST00000260950.4	-	3	880		c.e3-1		C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin						muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			AAAACGGATTCTGTTTGAAAA	0.358													13	43					0	0	1	0	0	T	190922365	C	T	190922365	5	4	48	1	0	0	0	0	0	0	1	0	9940	927	32	3	384	3	MSTN	2	190922365	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	367792	190922365	52277008	751	5145										
MYO1B	4430	broad.mit.edu	37	chr2	192225402	192225402	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaacagccaagaggtgaaaGaaacttccatgtgttctatc	8	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:192225402G>T	ENST00000392318.3	+	8	855	c.608G>T	c.(607-609)aGa>aTa	p.R203I	MYO1B_ENST00000304164.4_Missense_Mutation_p.R203I|MYO1B_ENST00000339514.4_Missense_Mutation_p.R203I|MYO1B_ENST00000392316.1_Missense_Mutation_p.R203I	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	203	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			AGAGGTGAAAGAAACTTCCAT	0.398													39	94					1.47244e-24	2.06782e-24	1	1	0	T	192225402	G	T	192225402	3	4	48	1	0	0	0	0	1	0	0	0	10116	942	33	2	634	2	MYO1B	2	192225402	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1303037	192225402	50973971	752	5146										
SLC39A10	57181	broad.mit.edu	37	chr2	196545041	196545041	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaacaaacttgggccttgGagagagaaaagtagttgaga	12	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:196545041G>A	ENST00000409086.3	+	2	550	c.275G>A	c.(274-276)gGa>gAa	p.G92E	SLC39A10_ENST00000359634.5_Missense_Mutation_p.G92E|SLC39A10_ENST00000541054.1_Intron	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	92					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TTGGGCCTTGGAGAGAGAAAA	0.338													37	43					0	0	1	0	0	A	196545041	G	A	196545041	3	1	48	1	0	0	0	0	1	0	0	0	14667	1174	41	3	277	3	SLC39A10	2	196545041	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4319639	196545041	46654332	753	5147										
DNAH7	56171	broad.mit.edu	37	chr2	196722256	196722256	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atattgtccttgtcatattcAtgaagtgactgcagaaacct	7	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:196722256A>G	ENST00000312428.6	-	44	8359	c.8259T>C	c.(8257-8259)caT>caC	p.H2753H		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2753	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TGTCATATTCATGAAGTGACT	0.368													4	48					0	0	1	0	0	G	196722256	A	G	196722256	2	3	48	1	0	0	0	0	0	0	0	1	4633	214	8	4		4	DNAH7	2	196722256	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	177215	196722256	46477117	754	5148										
DNAH7	56171	broad.mit.edu	37	chr2	196825183	196825183	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgccttttcaagagaatattCtttgctagctgcttcactaa	6	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:196825183C>A	ENST00000312428.6	-	18	2792	c.2692G>T	c.(2692-2694)Gaa>Taa	p.E898*		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	898	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGAGAATATTCTTTGCTAGCT	0.393													33	77					4.74835e-14	6.14782e-14	1	1	0	A	196825183	C	A	196825183	4	1	48	1	0	0	0	0	0	1	0	0	4633	922	32	2	9574	2	DNAH7	2	196825183	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	102927	196825183	46374190	755	5149										
DNAH7	56171	broad.mit.edu	37	chr2	196834764	196834764	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctccaaatgaataaaattCttctgattgcttagcataac	4	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:196834764C>A	ENST00000312428.6	-	17	2213	c.2113G>T	c.(2113-2115)Gaa>Taa	p.E705*		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	705	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GAATAAAATTCTTCTGATTGC	0.338													10	33					3.86212e-05	4.21111e-05	1	1	0	A	196834764	C	A	196834764	4	1	48	1	0	0	0	0	0	1	0	0	4633	922	32	2	10157	2	DNAH7	2	196834764	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9581	196834764	46364609	756	5150										
DNAH7	56171	broad.mit.edu	37	chr2	196912086	196912086	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacaacttacataatgacatTaacaagagtacttctaaagt	4	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:196912086T>C	ENST00000312428.6	-	5	488	c.388A>G	c.(388-390)Aat>Gat	p.N130D	DNAH7_ENST00000410072.1_Missense_Mutation_p.N130D	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	130	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATAATGACATTAACAAGAGTA	0.378													12	52					0	0	1	0	0	C	196912086	T	C	196912086	3	2	48	1	0	0	0	0	1	0	0	0	4633	1754	61	4	11930	4	DNAH7	2	196912086	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	77322	196912086	46287287	757	5151										
STK17B	9262	broad.mit.edu	37	chr2	197002227	197002227	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtaatgagtcatcgaaacGaaatcttttggaaaccatgc	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:197002227G>A	ENST00000263955.4	-	8	1349	c.1063C>T	c.(1063-1065)Cgt>Tgt	p.R355C	STK17B_ENST00000409228.1_Missense_Mutation_p.R355C	NM_004226.3	NP_004217.1	O94768	ST17B_HUMAN	serine/threonine kinase 17b	355					apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(10)	15			OV - Ovarian serous cystadenocarcinoma(117;0.141)			TCATCGAAACGAAATCTTTTG	0.373													17	44					0	0	1	0	0	A	197002227	G	A	197002227	3	1	48	1	0	0	0	0	1	0	0	0	15346	1058	37	1	59	1	STK17B	2	197002227	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	90141	197002227	46197146	758	5152										
HECW2	57520	broad.mit.edu	37	chr2	197183699	197183699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaggagctgtcagcgcattCcaggtcactctctccctcag	10	15	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:197183699C>T	ENST00000260983.2	-	9	2097	c.1915G>A	c.(1915-1917)Gaa>Aaa	p.E639K	HECW2_ENST00000409111.1_Missense_Mutation_p.E283K	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	639					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCAGCGCATTCCAGGTCACTC	0.587													12	31					0	0	1	0	0	T	197183699	C	T	197183699	3	4	48	1	0	0	0	0	1	0	0	0	7083	864	30	3	2887	3	HECW2	2	197183699	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	181472	197183699	46015674	759	5153										
HECW2	57520	broad.mit.edu	37	chr2	197208479	197208479	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcccagaagttggctggaGaattctcatctagaaaaacc	8	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:197208479G>T	ENST00000260983.2	-	3	484	c.302C>A	c.(301-303)tCt>tAt	p.S101Y	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	101					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GTTGGCTGGAGAATTCTCATC	0.378													57	77					2.17126e-26	3.07221e-26	1	1	0	T	197208479	G	T	197208479	3	4	48	1	0	0	0	0	1	0	0	0	7083	942	33	2	4524	2	HECW2	2	197208479	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24780	197208479	45990894	760	5154										
GTF3C3	9330	broad.mit.edu	37	chr2	197639893	197639893	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctgtctgatattttgtctCtcgatactttaataagataa	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:197639893C>T	ENST00000263956.3	-	13	1867	c.1778G>A	c.(1777-1779)aGa>aAa	p.R593K		NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	593						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TATTTTGTCTCTCGATACTTT	0.343													10	19					0	0	1	0	0	T	197639893	C	T	197639893	3	4	48	1	0	0	0	0	1	0	0	0	6914	913	32	3	906	3	GTF3C3	2	197639893	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	431414	197639893	45559480	761	5155										
ANKRD44	91526	broad.mit.edu	37	chr2	197954686	197954686	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacttacccgatgataacaActttctgcagcagtcagagt	7	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:197954686A>G	ENST00000328737.2	-	11	1172	c.1096T>C	c.(1096-1098)Ttg>Ctg	p.L366L	ANKRD44_ENST00000409153.1_Silent_p.L391L|ANKRD44_ENST00000337207.5_Silent_p.L366L|ANKRD44_ENST00000450567.1_Silent_p.L366L|ANKRD44_ENST00000282272.8_Silent_p.L383L|ANKRD44_ENST00000539527.1_Silent_p.L319L			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	391							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GATGATAACAACTTTCTGCAG	0.458													20	47					0	0	1	0	0	G	197954686	A	G	197954686	2	3	48	1	0	0	0	0	0	0	0	1	666	40	2	4		4	ANKRD44	2	197954686	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	314793	197954686	45244687	762	5156										
HSPD1	3329	broad.mit.edu	37	chr2	198359410	198359411	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgacaccctttcttccaacINSttttttcattgcatcagaga							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:198359410_198359411insT	ENST00000388968.3	-	5	843_844	c.576_577insA	c.(574-579)aattggfs	p.NW192fs	HSPD1_ENST00000345042.2_Frame_Shift_Ins_p.NW192fs	NM_002156.4	NP_002147.2	P10809	CH60_HUMAN	heat shock 60kDa protein 1 (chaperonin)	192					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(7)|skin(1)	17			Epithelial(96;0.225)			TTTCTTCCAACTTTTTTCATTG	0.327													15	38	---	---	---	---						T	198359411	-	T	198359410	7	5	48	1	0	1	1	0	0	0	0	0	7471	565	20	0	1176	0	HSPD1	2	198359410	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	404724	198359410	44839963	763	5157										
PLCL1	5334	broad.mit.edu	37	chr2	198950849	198950849	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagaatggggaagaaagttCgggaatataccatgctcagg	14	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:198950849C>T	ENST00000428675.1	+	2	3006	c.2608C>T	c.(2608-2610)Cgg>Tgg	p.R870W	PLCL1_ENST00000437704.2_Missense_Mutation_p.R772W	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	870					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GAAGAAAGTTCGGGAATATAC	0.418													16	43					0	0	1	0	0	T	198950849	C	T	198950849	3	4	48	1	0	0	0	0	1	0	0	0	12086	875	31	1	2614	1	PLCL1	2	198950849	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	591439	198950849	44248524	764	5158										
SATB2	23314	broad.mit.edu	37	chr2	200193516	200193516	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctcatcctggtagatgcGatctcgctccacttctggca	8	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:200193516G>A	ENST00000443023.1	-	7	2579	c.1114C>T	c.(1114-1116)Cgc>Tgc	p.R372C	RP11-486F17.1_ENST00000489557.2_RNA|SATB2_ENST00000417098.1_Missense_Mutation_p.R431C|SATB2_ENST00000428695.1_Missense_Mutation_p.R313C|SATB2_ENST00000260926.5_Missense_Mutation_p.R431C|SATB2_ENST00000457245.1_Missense_Mutation_p.R431C			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	431						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGTAGATGCGATCTCGCTCC	0.562													13	21					0	0	1	0	0	A	200193516	G	A	200193516	3	1	48	1	0	0	0	0	1	0	0	0	13906	1058	37	1	926	1	SATB2	2	200193516	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1242667	200193516	43005857	765	5159										
SGOL2	151246	broad.mit.edu	37	chr2	201434523	201434523	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatcaactcaggataattCggaagtgttatttcttaaag	7	5	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:201434523C>T	ENST00000357799.4	+	6	709	c.611C>T	c.(610-612)tCg>tTg	p.S204L	SGOL2_ENST00000409203.3_Missense_Mutation_p.S204L	NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	204					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						CAGGATAATTCGGAAGTGTTA	0.318													16	53					0	0	1	0	0	T	201434523	C	T	201434523	3	4	48	1	0	0	0	0	1	0	0	0	14270	893	31	1	629	1	SGOL2	2	201434523	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1241007	201434523	41764850	766	5160										
SGOL2	151246	broad.mit.edu	37	chr2	201436810	201436810	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaccaaagataatggaaatTtatgtgattatgggacccac	8	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:201436810T>G	ENST00000357799.4	+	7	1839	c.1741T>G	c.(1741-1743)Tta>Gta	p.L581V		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	581					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TAATGGAAATTTATGTGATTA	0.328													24	52					0	0	1	0	0	G	201436810	T	G	201436810	3	3	48	1	0	0	0	0	1	0	0	0	14270	1838	64	4	1763	4	SGOL2	2	201436810	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2287	201436810	41762563	767	5161										
SGOL2	151246	broad.mit.edu	37	chr2	201437472	201437472	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacctgcttgtcaaaatgaTtcaaaaataggtaagaagcc	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:201437472T>G	ENST00000357799.4	+	7	2501	c.2403T>G	c.(2401-2403)gaT>gaG	p.D801E		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	801					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						GTCAAAATGATTCAAAAATAG	0.348													13	59					0	0	1	0	0	G	201437472	T	G	201437472	3	3	48	1	0	0	0	0	1	0	0	0	14270	1490	52	4	2425	4	SGOL2	2	201437472	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	662	201437472	41761901	768	5162										
SGOL2	151246	broad.mit.edu	37	chr2	201437691	201437691	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatcaaagataatggaaaTttatgtgattatgacaccca	6	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:201437691T>G	ENST00000357799.4	+	7	2720	c.2622T>G	c.(2620-2622)aaT>aaG	p.N874K		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	874					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						ATAATGGAAATTTATGTGATT	0.308													6	70					0	0	1	0	0	G	201437691	T	G	201437691	3	3	48	1	0	0	0	0	1	0	0	0	14270	1490	52	4	2644	4	SGOL2	2	201437691	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	219	201437691	41761682	769	5163										
CFLAR	8837	broad.mit.edu	37	chr2	202025201	202025201	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggctatgaagtccagaaAttcttgcatctcagtatgca	9	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202025201A>T	ENST00000309955.2	+	9	1355	c.840A>T	c.(838-840)aaA>aaT	p.K280N	CFLAR_ENST00000423241.2_Missense_Mutation_p.K280N|CFLAR_ENST00000479953.2_Missense_Mutation_p.K184N|CFLAR_ENST00000340870.5_Missense_Mutation_p.K280N|CFLAR_ENST00000443227.1_Missense_Mutation_p.K184N|CFLAR_ENST00000457277.1_Missense_Mutation_p.K280N|CFLAR_ENST00000355558.4_Intron|CFLAR_ENST00000341582.6_Missense_Mutation_p.K245N	NM_003879.5	NP_003870.4	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator	280	Caspase.|Interaction with TRAF1 and TRAF2.|Interaction with caspase-3.|Interaction with caspase-8 propeptide.|Interaction with caspase-8 subunits p18 and p10.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|stomach(1)	13						AAGTCCAGAAATTCTTGCATC	0.478													52	96					0	0	1	0	0	T	202025201	A	T	202025201	3	4	48	1	0	0	0	0	1	0	0	0	3314	98	4	4	934	4	CFLAR	2	202025201	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	587510	202025201	41174172	770	5164										
CASP8	841	broad.mit.edu	37	chr2	202131412	202131412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgaaggagctgctcttccGaattaatagactggatttgc	10	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202131412G>A	ENST00000358485.4	+	2	576	c.380G>A	c.(379-381)cGa>cAa	p.R127Q	CASP8_ENST00000264274.9_Missense_Mutation_p.R68Q|CASP8_ENST00000264275.5_Missense_Mutation_p.R68Q|CASP8_ENST00000323492.7_Missense_Mutation_p.R68Q|CASP8_ENST00000432109.2_Missense_Mutation_p.R68Q|CASP8_ENST00000392266.3_Missense_Mutation_p.R68Q|CASP8_ENST00000392258.3_Missense_Mutation_p.R68Q|CASP8_ENST00000392259.2_Missense_Mutation_p.R68Q	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	68	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						CTGCTCTTCCGAATTAATAGA	0.453										HNSCC(4;0.00038)			13	32					0	0	1	0	0	A	202131412	G	A	202131412	3	1	48	1	0	0	0	0	1	0	0	0	2695	1058	37	1	386	1	CASP8	2	202131412	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	106211	202131412	41067961	771	5165										
CASP8	841	broad.mit.edu	37	chr2	202137360	202137360	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttatttctcctcctcttaGaacctgctggatattttcat	4	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202137360G>T	ENST00000358485.4	+	4	784		c.e4-1		CASP8_ENST00000264274.9_Splice_Site|CASP8_ENST00000264275.5_Splice_Site|CASP8_ENST00000323492.7_Splice_Site|CASP8_ENST00000432109.2_Splice_Site|CASP8_ENST00000392266.3_Splice_Site|CASP8_ENST00000392258.3_Splice_Site|CASP8_ENST00000392259.2_Splice_Site	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase						activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						CCTCCTCTTAGAACCTGCTGG	0.408										HNSCC(4;0.00038)			41	73					6.2361e-21	8.5756e-21	1	1	0	T	202137360	G	T	202137360	5	4	48	1	0	0	0	0	0	0	1	0	2695	956	33	2	702	2	CASP8	2	202137360	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5948	202137360	41062013	772	5166										
ALS2CR12	130540	broad.mit.edu	37	chr2	202154232	202154232	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatggtgtgcttatacttttCttcagtttcagcaaacttgg	8	7	3	0	rs149980324	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202154232C>A	ENST00000405148.2	-	14	1602	c.1159G>T	c.(1159-1161)Gaa>Taa	p.E387*	ALS2CR12_ENST00000286190.5_Nonsense_Mutation_p.E387*|ALS2CR12_ENST00000392257.3_Nonsense_Mutation_p.E364*|ALS2CR12_ENST00000439709.1_Nonsense_Mutation_p.E364*	NM_139163.2	NP_631902.2	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	387					regulation of GTPase activity		protein binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)	21						TTATACTTTTCTTCAGTTTCA	0.418													24	68					9.39395e-14	1.21013e-13	1	1	0	A	202154232	C	A	202154232	4	1	48	1	0	0	0	0	0	1	0	0	549	922	32	2	186	2	ALS2CR12	2	202154232	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16872	202154232	41045141	773	5167										
TRAK2	66008	broad.mit.edu	37	chr2	202257694	202257694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtagggccagatctactacGaagttcctttatttcttctt	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202257694G>A	ENST00000332624.3	-	10	1479	c.1051C>T	c.(1051-1053)Cgt>Tgt	p.R351C		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	351				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						GATCTACTACGAAGTTCCTTT	0.388													15	8					0	0	1	0	0	A	202257694	G	A	202257694	3	1	48	1	0	0	0	0	1	0	0	0	16510	1058	37	1	1721	1	TRAK2	2	202257694	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	103462	202257694	40941679	774	5168										
TRAK2	66008	broad.mit.edu	37	chr2	202263032	202263032	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagcaatggagacgattcGaagtaactcatctttcttgc	9	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202263032G>A	ENST00000332624.3	-	6	954	c.526C>T	c.(526-528)Cga>Tga	p.R176*	TRAK2_ENST00000430254.1_Nonsense_Mutation_p.R176*	NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	176						early endosome|plasma membrane	GABA receptor binding	p.R176*(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						GAGACGATTCGAAGTAACTCA	0.383													20	39					0	0	1	0	0	A	202263032	G	A	202263032	4	1	48	1	0	0	0	0	0	1	0	0	16510	1066	37	1	2262	1	TRAK2	2	202263032	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5338	202263032	40936341	775	5169										
MPP4	58538	broad.mit.edu	37	chr2	202510068	202510068	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaatcacatgatcaaaaaaTtggccaaactgagtttccat	5	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202510068T>C	ENST00000409474.3	-	22	1986	c.1779A>G	c.(1777-1779)caA>caG	p.Q593Q	MPP4_ENST00000428900.2_Silent_p.Q569Q|MPP4_ENST00000447335.2_Silent_p.Q586Q|MPP4_ENST00000315506.7_Silent_p.Q549Q|MPP4_ENST00000359962.5_Silent_p.Q593Q|MPP4_ENST00000396886.3_Silent_p.Q518Q|MPP4_ENST00000409143.1_Silent_p.Q535Q	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	593	Guanylate kinase-like.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GATCAAAAAATTGGCCAAACT	0.418													19	30					0	0	1	0	0	C	202510068	T	C	202510068	2	2	48	1	0	0	0	0	0	0	0	1	9784	1490	52	4		4	MPP4	2	202510068	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	247036	202510068	40689305	776	5170										
MPP4	58538	broad.mit.edu	37	chr2	202510091	202510091	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccaaactgagtttccattcTttgggctaaattttccatct	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:202510091T>A	ENST00000409474.3	-	22	1963	c.1756A>T	c.(1756-1758)Aga>Tga	p.R586*	MPP4_ENST00000428900.2_Nonsense_Mutation_p.R562*|MPP4_ENST00000447335.2_Nonsense_Mutation_p.R579*|MPP4_ENST00000315506.7_Nonsense_Mutation_p.R542*|MPP4_ENST00000359962.5_Nonsense_Mutation_p.R586*|MPP4_ENST00000396886.3_Nonsense_Mutation_p.R511*|MPP4_ENST00000409143.1_Nonsense_Mutation_p.R528*	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	586	Guanylate kinase-like.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GTTTCCATTCTTTGGGCTAAA	0.378													5	35					0	0	1	0	0	A	202510091	T	A	202510091	4	1	48	1	0	0	0	0	0	1	0	0	9784	1617	56	4	161	4	MPP4	2	202510091	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23	202510091	40689282	777	5171										
BMPR2	659	broad.mit.edu	37	chr2	203379620	203379620	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttcttataggagaccgtaAacaaggtcttcacagtatga	9	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:203379620A>G	ENST00000374580.4	+	5	1078	c.539A>G	c.(538-540)aAa>aGa	p.K180R	BMPR2_ENST00000374574.2_Missense_Mutation_p.K180R	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	180					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						GGAGACCGTAAACAAGGTCTT	0.343													15	21					0	0	1	0	0	G	203379620	A	G	203379620	3	3	48	1	0	0	0	0	1	0	0	0	1470	14	1	4	557	4	BMPR2	2	203379620	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	869529	203379620	39819753	778	5172										
ICA1L	130026	broad.mit.edu	37	chr2	203653775	203653775	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaattccttctcaaaatcttCtccttccaatgaatctacag	3	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:203653775C>A	ENST00000392237.2	-	12	1178	c.1021G>T	c.(1021-1023)Gaa>Taa	p.E341*	ICA1L_ENST00000358299.2_Nonsense_Mutation_p.E341*	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	341										breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCAAAATCTTCTCCTTCCAAT	0.368													15	55					2.32078e-09	2.7896e-09	1	1	0	A	203653775	C	A	203653775	4	1	48	1	0	0	0	0	0	1	0	0	7521	922	32	2	439	2	ICA1L	2	203653775	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	274155	203653775	39545598	779	5173										
NBEAL1	65065	broad.mit.edu	37	chr2	204013739	204013739	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttgtggagccatttaatcGaaaagcacgccaagagaacc	10	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:204013739G>A	ENST00000449802.1	+	33	5576	c.5243G>A	c.(5242-5244)cGa>cAa	p.R1748Q		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1748							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CCATTTAATCGAAAAGCACGC	0.343													22	38					0	0	1	0	0	A	204013739	G	A	204013739	3	1	48	1	0	0	0	0	1	0	0	0	10235	1058	37	1	5369	1	NBEAL1	2	204013739	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	359964	204013739	39185634	780	5174										
CYP20A1	57404	broad.mit.edu	37	chr2	204154520	204154520	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgctttgtgaaactgttcGaactgccaaactgactccag	9	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:204154520G>A	ENST00000356079.4	+	10	1127	c.1004G>A	c.(1003-1005)cGa>cAa	p.R335Q	CYP20A1_ENST00000461371.1_3'UTR|CYP20A1_ENST00000429815.2_Missense_Mutation_p.R343Q	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	335						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						GAAACTGTTCGAACTGCCAAA	0.323													23	26					0	0	1	0	0	A	204154520	G	A	204154520	3	1	48	1	0	0	0	0	1	0	0	0	4175	1058	37	1	1042	1	CYP20A1	2	204154520	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	140781	204154520	39044853	781	5175										
EEF1B2	1933	broad.mit.edu	37	chr2	207024682	207024682	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctttctgctgctccccaGctctcggatacagccgacac	7	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207024682G>A	ENST00000236957.5	+	2	100		c.e2-1		EEF1B2_ENST00000392221.1_5'UTR|EEF1B2_ENST00000392222.2_5'UTR	NM_021121.3	NP_066944.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2							cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CTGCTCCCCAGCTCTCGGATA	0.567													47	86					0	0	1	0	0	A	207024682	G	A	207024682	5	1	48	1	0	0	0	0	0	0	1	0	4951	985	34	3		3	EEF1B2	2	207024682	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2870162	207024682	36174691	782	5176										
ZDBF2	57683	broad.mit.edu	37	chr2	207170663	207170663	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcccaaatgattgttaaaGaaataagtcttcagaatgca	6	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207170663G>T	ENST00000374423.3	+	5	1797	c.1411G>T	c.(1411-1413)Gaa>Taa	p.E471*		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	471							nucleic acid binding|zinc ion binding	p.E471*(2)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GATTGTTAAAGAAATAAGTCT	0.333													9	23					0.000274275	0.000292037	1	1	0	T	207170663	G	T	207170663	4	4	48	1	0	0	0	0	0	1	0	0	17656	943	33	2	1421	2	ZDBF2	2	207170663	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	145981	207170663	36028710	783	5177										
ZDBF2	57683	broad.mit.edu	37	chr2	207173411	207173411	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcttcaaaaacctgtcaaaGaaataaatctttggaaggaa	7	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207173411G>T	ENST00000374423.3	+	5	4545	c.4159G>T	c.(4159-4161)Gaa>Taa	p.E1387*		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1387							nucleic acid binding|zinc ion binding	p.E1387K(2)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ACCTGTCAAAGAAATAAATCT	0.353													14	20					6.31663e-08	7.35827e-08	1	1	0	T	207173411	G	T	207173411	4	4	48	1	0	0	0	0	0	1	0	0	17656	943	33	2	4169	2	ZDBF2	2	207173411	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2748	207173411	36025962	784	5178										
ZDBF2	57683	broad.mit.edu	37	chr2	207174556	207174556	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcctcaagaaactgttaaGaaaagacacccttgtaagaa	7	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207174556G>T	ENST00000374423.3	+	5	5690	c.5304G>T	c.(5302-5304)aaG>aaT	p.K1768N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1768							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AAACTGTTAAGAAAAGACACC	0.423													11	22					0.000978159	0.00102903	1	1	0	T	207174556	G	T	207174556	3	4	48	1	0	0	0	0	1	0	0	0	17656	933	33	2	5314	2	ZDBF2	2	207174556	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1145	207174556	36024817	785	5179										
ADAM23	8745	broad.mit.edu	37	chr2	207414845	207414845	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtggtatatttgaagaaatGaaatatttggaacttatgat	9	2	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207414845G>T	ENST00000264377.3	+	9	1222	c.894G>T	c.(892-894)atG>atT	p.M298I	ADAM23_ENST00000374415.3_Missense_Mutation_p.M298I|ADAM23_ENST00000374416.1_Missense_Mutation_p.M298I	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	298					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TTGAAGAAATGAAATATTTGG	0.303													6	16					0.0215528	0.0219788	1	1	0	T	207414845	G	T	207414845	3	4	48	1	0	0	0	0	1	0	0	0	244	1290	45	2	928	2	ADAM23	2	207414845	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	240289	207414845	35784528	786	5180										
DYTN	391475	broad.mit.edu	37	chr2	207575305	207575305	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttctataaatggaattctCaatactattaagagcatctg	6	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207575305C>T	ENST00000452335.2	-	2	153	c.37G>A	c.(37-39)Gag>Aag	p.E13K		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	13						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		ATGGAATTCTCAATACTATTA	0.323													9	6					0	0	1	0	0	T	207575305	C	T	207575305	3	4	48	1	0	0	0	0	1	0	0	0	4887	835	29	3	1743	3	DYTN	2	207575305	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	160460	207575305	35624068	787	5181										
CPO	130749	broad.mit.edu	37	chr2	207827337	207827337	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaagtaaccacccagaaaTggtgagtccatagcaccaag	8	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:207827337T>C	ENST00000272852.3	+	7	822	c.777_splice	c.e7+1	p.M259_splice		NM_173077.2	NP_775100.1	Q8IVL8	CBPO_HUMAN	carboxypeptidase O	259					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		CACCCAGAAATGGTGAGTCCA	0.443													26	41					0	0	1	0	0	C	207827337	T	C	207827337	5	2	48	1	0	0	0	0	0	0	1	0	3843	1478	51	4	802	4	CPO	2	207827337	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	252032	207827337	35372036	788	5182										
CCNYL1	151195	broad.mit.edu	37	chr2	208591568	208591568	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattttttttattcttagtgCgagaaaagaggaagagcaac	9	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:208591568C>T	ENST00000295414.3	+	3	509	c.298C>T	c.(298-300)Cga>Tga	p.R100*	CCNYL1_ENST00000392209.3_Nonsense_Mutation_p.R30*|CCNYL1_ENST00000339882.5_Nonsense_Mutation_p.R100*			Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1	100					regulation of cyclin-dependent protein kinase activity		protein kinase binding			endometrium(1)|large_intestine(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)		ATTCTTAGTGCGAGAAAAGAG	0.299													32	65					0	0	1	0	0	T	208591568	C	T	208591568	4	4	48	1	0	0	0	0	0	1	0	0	2959	760	27	1	308	1	CCNYL1	2	208591568	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	764231	208591568	34607805	789	5183										
PIKFYVE	200576	broad.mit.edu	37	chr2	209182661	209182661	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccaagaacattgcacataAaaaggtaatgtgattcagtt	7	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:209182661A>C	ENST00000264380.4	+	16	2236	c.2078A>C	c.(2077-2079)aAa>aCa	p.K693T		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	693					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						ATTGCACATAAAAAGGTAATG	0.378													21	36					0	0	1	0	0	C	209182661	A	C	209182661	3	2	48	1	0	0	0	0	1	0	0	0	11971	14	1	4	2147	4	PIKFYVE	2	209182661	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	591093	209182661	34016712	790	5184										
MAP2	4133	broad.mit.edu	37	chr2	210557675	210557675	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagcctccaactccaaaaGaacaaaaggactggttcatc	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:210557675G>T	ENST00000360351.4	+	7	1287	c.781G>T	c.(781-783)Gaa>Taa	p.E261*	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000447185.1_Nonsense_Mutation_p.E257*|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	261					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AACTCCAAAAGAACAAAAGGA	0.498													24	57					1.10923e-09	1.34134e-09	1	1	0	T	210557675	G	T	210557675	4	4	48	1	0	0	0	0	0	1	0	0	9284	943	33	2	795	2	MAP2	2	210557675	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1375014	210557675	32641698	791	5185										
MAP2	4133	broad.mit.edu	37	chr2	210560590	210560590	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatctgaaccagcagagatTcagagtgaggaagaagagat	13	5	2	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:210560590T>G	ENST00000360351.4	+	7	4202	c.3696T>G	c.(3694-3696)atT>atG	p.I1232M	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.I1228M|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1232					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CAGCAGAGATTCAGAGTGAGG	0.478													24	36					0	0	1	0	0	G	210560590	T	G	210560590	3	3	48	1	0	0	0	0	1	0	0	0	9284	1771	62	4	3710	4	MAP2	2	210560590	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2915	210560590	32638783	792	5186										
CPS1	1373	broad.mit.edu	37	chr2	211469846	211469846	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcctttgctatgaccaaccaAattctggtggagaagtcagt	10	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:211469846A>G	ENST00000233072.5	+	17	2053	c.1857A>G	c.(1855-1857)caA>caG	p.Q619Q	CPS1_ENST00000430249.2_Silent_p.Q625Q|CPS1_ENST00000451903.2_Silent_p.Q168Q	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	619	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGACCAACCAAATTCTGGTGG	0.398													10	25					0	0	1	0	0	G	211469846	A	G	211469846	2	3	48	1	0	0	0	0	0	0	0	1	3846	11	1	4		4	CPS1	2	211469846	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	909256	211469846	31729527	793	5187										
ERBB4	2066	broad.mit.edu	37	chr2	213403311	213403311	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtccaaatggcatatccccCtttcgggcacgcggaggaga	12	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:213403311C>A	ENST00000342788.4	-	0	254				ERBB4_ENST00000436443.1_De_novo_Start_OutOfFrame	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4						cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GCATATCCCCCTTTCGGGCAC	0.667										TSP Lung(8;0.080)			15	22					1.05317e-09	1.27574e-09	1	1	0	A	213403311	C	A	213403311	1	1	48	1	0	0	0	0	0	0	0	0	5237	696	24	5		5	ERBB4	2	213403311	Translation_Start_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1933465	213403311	29796062	794	5188										
BARD1	580	broad.mit.edu	37	chr2	215632245	215632245	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cataggaaagtaacagcttgActatatccacatgcccattc	6	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:215632245A>G	ENST00000260947.4	-	6	1663	c.1529T>C	c.(1528-1530)gTc>gCc	p.V510A	BARD1_ENST00000449967.2_Missense_Mutation_p.V366A	NM_000465.2	NP_000456.2	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	510					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TAACAGCTTGACTATATCCAC	0.408									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				11	29					0	0	1	0	0	G	215632245	A	G	215632245	3	3	48	1	0	0	0	0	1	0	0	0	1310	275	10	4	828	4	BARD1	2	215632245	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2228934	215632245	27567128	795	5189										
ABCA12	26154	broad.mit.edu	37	chr2	215868969	215868969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcaatagttcaacagcatCgagtcccacggagaacttta	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:215868969C>T	ENST00000272895.7	-	20	2866	c.2647G>A	c.(2647-2649)Gat>Aat	p.D883N	ABCA12_ENST00000389661.4_Missense_Mutation_p.D565N	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	883					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCAACAGCATCGAGTCCCACG	0.333													9	18					0	0	1	0	0	T	215868969	C	T	215868969	3	4	48	1	0	0	0	0	1	0	0	0	30	884	31	1	5276	1	ABCA12	2	215868969	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	236724	215868969	27330404	796	5190										
ABCA12	26154	broad.mit.edu	37	chr2	215884496	215884496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagattcacaaagaagttCggtcaagtttcgaagttgag	10	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:215884496C>T	ENST00000272895.7	-	12	1531	c.1312G>A	c.(1312-1314)Gaa>Aaa	p.E438K	ABCA12_ENST00000389661.4_Missense_Mutation_p.E120K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	438					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CAAAGAAGTTCGGTCAAGTTT	0.368													13	33					0	0	1	0	0	T	215884496	C	T	215884496	3	4	48	1	0	0	0	0	1	0	0	0	30	893	31	1	6643	1	ABCA12	2	215884496	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15527	215884496	27314877	797	5191										
VIL1	7429	broad.mit.edu	37	chr2	219296879	219296879	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctacctcatcggcgagaaGcagcattacctgctctacgt	8	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:219296879G>A	ENST00000248444.5	+	12	1402	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K	VIL1_ENST00000392114.2_Silent_p.K127K	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	438	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCGGCGAGAAGCAGCATTACC	0.572													18	28					0	0	1	0	0	A	219296879	G	A	219296879	2	1	48	1	0	0	0	0	0	0	0	1	17223	962	34	3		3	VIL1	2	219296879	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3412383	219296879	23902494	798	5192										
USP37	57695	broad.mit.edu	37	chr2	219330886	219330886	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtctttagttatctcagtAaaactggcaggatctgagga	10	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:219330886A>C	ENST00000258399.3	-	21	2725	c.2313T>G	c.(2311-2313)ttT>ttG	p.F771L	USP37_ENST00000415516.1_Missense_Mutation_p.F677L|USP37_ENST00000418019.1_Missense_Mutation_p.F771L|USP37_ENST00000454775.1_Missense_Mutation_p.F771L	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	771					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TTATCTCAGTAAAACTGGCAG	0.378													14	40					0	0	1	0	0	C	219330886	A	C	219330886	3	2	48	1	0	0	0	0	1	0	0	0	17127	359	13	4	650	4	USP37	2	219330886	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	34007	219330886	23868487	799	5193										
PLCD4	84812	broad.mit.edu	37	chr2	219487377	219487377	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctctcttgcaggcagcagAcacgtcccagtctggaaccc	9	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:219487377A>G	ENST00000450993.2	+	6	887	c.548A>G	c.(547-549)gAc>gGc	p.D183G	PLCD4_ENST00000417849.1_Missense_Mutation_p.D183G|PLCD4_ENST00000432688.1_Missense_Mutation_p.D183G	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	183	EF-hand 2.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CAGGCAGCAGACACGTCCCAG	0.373													9	26					0	0	1	0	0	G	219487377	A	G	219487377	3	3	48	1	0	0	0	0	1	0	0	0	12080	275	10	4	566	4	PLCD4	2	219487377	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	156491	219487377	23711996	800	5194										
CCDC108	255101	broad.mit.edu	37	chr2	219900213	219900213	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tactggtacctgtacttcatCttctggagtttcaaggatcg	9	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:219900213C>A	ENST00000341552.5	-	5	614	c.531G>T	c.(529-531)aaG>aaT	p.K177N	CCDC108_ENST00000295729.2_Missense_Mutation_p.K112N|CCDC108_ENST00000324264.6_Missense_Mutation_p.K112N|CCDC108_ENST00000409865.3_Missense_Mutation_p.K166N|CCDC108_ENST00000441968.1_Missense_Mutation_p.K177N|CCDC108_ENST00000410037.1_Missense_Mutation_p.K112N|CCDC108_ENST00000453220.1_Missense_Mutation_p.K177N	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	177						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTACTTCATCTTCTGGAGTT	0.468													27	52					4.7796e-09	5.70246e-09	1	1	0	A	219900213	C	A	219900213	3	1	48	1	0	0	0	0	1	0	0	0	2761	912	32	2	5518	2	CCDC108	2	219900213	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	412836	219900213	23299160	801	5195										
SLC23A3	151295	broad.mit.edu	37	chr2	220026863	220026863	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctgggcttctgaggcattCgagcctcttgggcagtgaaa	13	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:220026863C>T	ENST00000455516.2	-	12	1672	c.1625G>A	c.(1624-1626)cGa>cAa	p.R542Q	SLC23A3_ENST00000396775.3_3'UTR|SLC23A3_ENST00000295738.7_Missense_Mutation_p.R417Q|SLC23A3_ENST00000409878.3_Missense_Mutation_p.R534Q	NM_001144890.1	NP_001138362.1	Q6PIS1	S23A3_HUMAN	solute carrier family 23, member 3	534					transmembrane transport	integral to membrane	protein binding|transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	11		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGAGGCATTCGAGCCTCTTG	0.567													10	56					0	0	1	0	0	T	220026863	C	T	220026863	3	4	48	1	0	0	0	0	1	0	0	0	14518	884	31	1	235	1	SLC23A3	2	220026863	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	126650	220026863	23172510	802	5196										
SLC4A3	6508	broad.mit.edu	37	chr2	220501573	220501573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcactcattttcatctacGagaccttctacaagctctac	3	14	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:220501573G>A	ENST00000358055.3	+	16	3024	c.2512G>A	c.(2512-2514)Gag>Aag	p.E838K	SLC4A3_ENST00000373760.2_Missense_Mutation_p.E838K|SLC4A3_ENST00000373762.3_Missense_Mutation_p.E865K|SLC4A3_ENST00000273063.6_Missense_Mutation_p.E865K|SLC4A3_ENST00000317151.3_Missense_Mutation_p.E838K			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	838	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTTCATCTACGAGACCTTCTA	0.582													37	90					0	0	1	0	0	A	220501573	G	A	220501573	3	1	48	1	0	0	0	0	1	0	0	0	14709	1059	37	1	2651	1	SLC4A3	2	220501573	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	474710	220501573	22697800	803	5197										
SLC4A3	6508	broad.mit.edu	37	chr2	220502517	220502517	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgcaagttcaggaacagccGcttcctggggggcaaggtgc	16	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:220502517G>A	ENST00000358055.3	+	17	3262	c.2750G>A	c.(2749-2751)cGc>cAc	p.R917H	SLC4A3_ENST00000373760.2_Missense_Mutation_p.R917H|SLC4A3_ENST00000373762.3_Missense_Mutation_p.R944H|SLC4A3_ENST00000273063.6_Missense_Mutation_p.R944H|SLC4A3_ENST00000317151.3_Missense_Mutation_p.R917H			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	917	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGAACAGCCGCTTCCTGGGG	0.622													22	45					0	0	1	0	0	A	220502517	G	A	220502517	3	1	48	1	0	0	0	0	1	0	0	0	14709	1087	38	1	2893	1	SLC4A3	2	220502517	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	944	220502517	22696856	804	5198										
EPHA4	2043	broad.mit.edu	37	chr2	222307707	222307707	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttgccaggcactttgagaCgcccactgcatacctcacca	7	16	2	1	rs147566564		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:222307707C>T	ENST00000281821.2	-	11	1957	c.1916G>A	c.(1915-1917)cGt>cAt	p.R639H	EPHA4_ENST00000409938.1_Missense_Mutation_p.R639H|EPHA4_ENST00000409854.1_Missense_Mutation_p.R639H|EPHA4_ENST00000392071.4_Missense_Mutation_p.R588H	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	639	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CACTTTGAGACGCCCACTGCA	0.448													16	44					0	0	1	0	0	T	222307707	C	T	222307707	3	4	48	1	0	0	0	0	1	0	0	0	5197	536	19	1	1072	1	EPHA4	2	222307707	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1805190	222307707	20891666	805	5199										
FARSB	10056	broad.mit.edu	37	chr2	223513464	223513464	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatccaatacatacaatttCatcaagctccagaccaaatt	2	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:223513464C>A	ENST00000281828.6	-	2	372	c.109G>T	c.(109-111)Gaa>Taa	p.E37*	FARSB_ENST00000536361.1_5'UTR	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	37					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	CATACAATTTCATCAAGCTCC	0.299													21	55					4.30721e-22	5.97715e-22	1	1	0	A	223513464	C	A	223513464	4	1	48	1	0	0	0	0	0	1	0	0	5712	835	29	2	1724	2	FARSB	2	223513464	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1205757	223513464	19685909	806	5200										
MRPL44	65080	broad.mit.edu	37	chr2	224822309	224822309	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggattccgcgccgccttccgCttccagaaggagttagagcg	13	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:224822309C>A	ENST00000258383.3	+	1	189	c.120C>A	c.(118-120)cgC>cgA	p.R40R		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	40					RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		CCGCCTTCCGCTTCCAGAAGG	0.692													10	35					2.17888e-05	2.39107e-05	1	1	0	A	224822309	C	A	224822309	2	1	48	1	0	0	0	0	0	0	0	1	9856	784	28	5		5	MRPL44	2	224822309	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1308845	224822309	18377064	807	5201										
DOCK10	55619	broad.mit.edu	37	chr2	225662652	225662652	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcaaagacccttttcatcAatgaattttgacagtcacat	4	9	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:225662652A>G	ENST00000409592.3	-	42	4636	c.4523T>C	c.(4522-4524)tTg>tCg	p.L1508S	DOCK10_ENST00000258390.7_Missense_Mutation_p.L1514S			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1514							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CCTTTTCATCAATGAATTTTG	0.368													22	27					0	0	1	0	0	G	225662652	A	G	225662652	3	3	48	1	0	0	0	0	1	0	0	0	4712	131	5	4	2079	4	DOCK10	2	225662652	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	840343	225662652	17536721	808	5202										
DOCK10	55619	broad.mit.edu	37	chr2	225668910	225668910	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgggtggactgcacaaatTtaaatgcagcagcaattttt	9	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:225668910T>G	ENST00000409592.3	-	39	4282	c.4169A>C	c.(4168-4170)aAa>aCa	p.K1390T	DOCK10_ENST00000258390.7_Missense_Mutation_p.K1396T			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1396							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTGCACAAATTTAAATGCAGC	0.373													7	19					0	0	1	0	0	G	225668910	T	G	225668910	3	3	48	1	0	0	0	0	1	0	0	0	4712	1841	64	4	2445	4	DOCK10	2	225668910	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	6258	225668910	17530463	809	5203										
DOCK10	55619	broad.mit.edu	37	chr2	225672668	225672668	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaatgaatgcttagccattAgattttttaggacagctaaa	7	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:225672668A>C	ENST00000409592.3	-	32	3640	c.3527T>G	c.(3526-3528)cTa>cGa	p.L1176R	DOCK10_ENST00000258390.7_Missense_Mutation_p.L1182R			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1182							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTTAGCCATTAGATTTTTTAG	0.423													4	10					0	0	1	0	0	C	225672668	A	C	225672668	3	2	48	1	0	0	0	0	1	0	0	0	4712	420	15	4	3115	4	DOCK10	2	225672668	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3758	225672668	17526705	810	5204										
DOCK10	55619	broad.mit.edu	37	chr2	225761087	225761087	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccactgggaactataaaatTtacaagcctgaaagaaagaa	8	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:225761087T>G	ENST00000409592.3	-	4	436	c.323A>C	c.(322-324)aAa>aCa	p.K108T	DOCK10_ENST00000474102.1_5'UTR|DOCK10_ENST00000258390.7_Missense_Mutation_p.K114T			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	114							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ACTATAAAATTTACAAGCCTG	0.383													7	13					0	0	1	0	0	G	225761087	T	G	225761087	3	3	48	1	0	0	0	0	1	0	0	0	4712	1841	64	4	6431	4	DOCK10	2	225761087	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	88419	225761087	17438286	811	5205										
MFF	56947	broad.mit.edu	37	chr2	228207487	228207487	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagatcagattctgccccaaGaaataaaatttcaaggttcc	6	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:228207487G>T	ENST00000353339.3	+	7	986	c.545G>T	c.(544-546)aGa>aTa	p.R182I	MFF_ENST00000354503.6_Intron|MFF_ENST00000304593.9_Intron|MFF_ENST00000524634.1_Intron|MFF_ENST00000349901.7_Intron|MFF_ENST00000337110.7_Missense_Mutation_p.R156I|MFF_ENST00000409616.1_Intron|MFF_ENST00000476924.1_Intron|MFF_ENST00000392059.1_Missense_Mutation_p.R182I|MFF_ENST00000409565.1_Intron	NM_001277061.1	NP_001263990.1	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	182						integral to membrane|mitochondrial outer membrane				breast(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(4)|stomach(2)	21						TCTGCCCCAAGAAATAAAATT	0.348													16	56					4.7546e-09	5.67505e-09	1	1	0	T	228207487	G	T	228207487	3	4	48	1	0	0	0	0	1	0	0	0	9568	942	33	2	563	2	MFF	2	228207487	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2446400	228207487	14991886	812	5206										
MFF	56947	broad.mit.edu	37	chr2	228221712	228221712	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcacttagataatcaaacTaaatagacgtctacaacttc	3	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:228221712T>C	ENST00000353339.3	+	11	1349	c.908T>C	c.(907-909)cTa>cCa	p.L303P	MFF_ENST00000354503.6_Missense_Mutation_p.L179P|MFF_ENST00000304593.9_Missense_Mutation_p.L252P|MFF_ENST00000524634.1_Missense_Mutation_p.L50P|MFF_ENST00000349901.7_Missense_Mutation_p.L199P|MFF_ENST00000337110.7_Missense_Mutation_p.L204P|MFF_ENST00000409616.1_Missense_Mutation_p.L199P|MFF_ENST00000476924.1_3'UTR|MFF_ENST00000392059.1_Missense_Mutation_p.L303P|MFF_ENST00000409565.1_Missense_Mutation_p.L179P	NM_001277061.1	NP_001263990.1	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	303						integral to membrane|mitochondrial outer membrane				breast(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(4)|stomach(2)	21						ATAATCAAACTAAATAGACGT	0.308													6	109					0	0	1	0	0	C	228221712	T	C	228221712	3	2	48	1	0	0	0	0	1	0	0	0	9568	1522	53	4	942	4	MFF	2	228221712	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	14225	228221712	14977661	813	5207										
AGFG1	3267	broad.mit.edu	37	chr2	228416723	228416723	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgcccacaggattcggcaCtcctgctccctacagtcttc	7	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:228416723C>A	ENST00000310078.7	+	11	1687	c.1427C>A	c.(1426-1428)aCt>aAt	p.T476N	AGFG1_ENST00000373671.3_Missense_Mutation_p.T436N|AGFG1_ENST00000409979.2_Missense_Mutation_p.T500N|AGFG1_ENST00000409315.1_Missense_Mutation_p.T455N|AGFG1_ENST00000409171.1_Missense_Mutation_p.T476N	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	476					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						GGATTCGGCACTCCTGCTCCC	0.507													5	110					0.217242	0.218251	1	1	0	A	228416723	C	A	228416723	3	1	48	1	0	0	0	0	1	0	0	0	377	565	20	5	1545	5	AGFG1	2	228416723	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	195011	228416723	14782650	814	5208										
SPHKAP	80309	broad.mit.edu	37	chr2	228858265	228858265	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttacttaatcatgggagaaGatggcatgctttcctgataa	9	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:228858265G>T	ENST00000392056.3	-	9	4752	c.4706C>A	c.(4705-4707)tCt>tAt	p.S1569Y	SPHKAP_ENST00000344657.5_Intron	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1569						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATGGGAGAAGATGGCATGCT	0.423													3	5					0.115264	0.116507	1	1	0	T	228858265	G	T	228858265	3	4	48	1	0	0	0	0	1	0	0	0	15103	942	33	2	412	2	SPHKAP	2	228858265	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	441542	228858265	14341108	815	5209										
SPHKAP	80309	broad.mit.edu	37	chr2	228884217	228884217	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatctggactctgaacaacGacgattttggggagctcatt	10	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:228884217G>A	ENST00000392056.3	-	7	1399	c.1353C>T	c.(1351-1353)gtC>gtT	p.V451V	SPHKAP_ENST00000344657.5_Silent_p.V451V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	451						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTGAACAACGACGATTTTGG	0.507													26	58					0	0	1	0	0	A	228884217	G	A	228884217	2	1	48	1	0	0	0	0	0	0	0	1	15103	1045	37	1		1	SPHKAP	2	228884217	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25952	228884217	14315156	816	5210										
DNER	92737	broad.mit.edu	37	chr2	230411675	230411675	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccttacctctgacggcttCgtggtgcattttccttttcc	7	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:230411675C>T	ENST00000341772.4	-	5	1115	c.981G>A	c.(979-981)acG>acA	p.T327T		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	327	EGF-like 3.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CTGACGGCTTCGTGGTGCATT	0.453													45	80					0	0	1	0	0	T	230411675	C	T	230411675	2	4	48	1	0	0	0	0	0	0	0	1	4694	871	31	1		1	DNER	2	230411675	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1527458	230411675	12787698	817	5211										
TRIP12	9320	broad.mit.edu	37	chr2	230642058	230642058	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcttgttcaagtcttttCttctgtctgacaatgtcttc	5	9	7	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:230642058C>A	ENST00000283943.5	-	36	5455	c.5277G>T	c.(5275-5277)aaG>aaT	p.K1759N	TRIP12_ENST00000389045.3_Missense_Mutation_p.K1489N|TRIP12_ENST00000389044.4_Missense_Mutation_p.K1807N	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1759					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CAAGTCTTTTCTTCTGTCTGA	0.378													50	64					3.19319e-46	4.62646e-46	1	1	0	A	230642058	C	A	230642058	3	1	48	1	0	0	0	0	1	0	0	0	16616	912	32	2	725	2	TRIP12	2	230642058	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	230383	230642058	12557315	818	5212										
TRIP12	9320	broad.mit.edu	37	chr2	230670526	230670526	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcattgatttgctgcataGaattaaaatcaatagtataa	5	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:230670526G>T	ENST00000389045.3	-	15	1607	c.1535C>A	c.(1534-1536)tCt>tAt	p.S512Y	TRIP12_ENST00000283943.5_Intron|TRIP12_ENST00000389044.4_Intron|TRIP12_ENST00000543084.1_Intron			Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	784					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TTGCTGCATAGAATTAAAATC	0.428													4	13					0.00909568	0.00935351	1	1	0	T	230670526	G	T	230670526	3	4	48	1	0	0	0	0	1	0	0	0	16616	957	33	2		2	TRIP12	2	230670526	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	28468	230670526	12528847	819	5213										
NCL	4691	broad.mit.edu	37	chr2	232322392	232322392	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccacctctatagtcttgaTtttgacctttctctccagta	4	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:232322392T>G	ENST00000322723.4	-	9	1649	c.1409A>C	c.(1408-1410)aAt>aCt	p.N470T		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	470					angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ATAGTCTTGATTTTGACCTTT	0.418													38	61					0	0	1	0	0	G	232322392	T	G	232322392	3	3	48	1	0	0	0	0	1	0	0	0	10272	1493	52	4	747	4	NCL	2	232322392	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1651866	232322392	10876981	820	5214										
COPS7B	64708	broad.mit.edu	37	chr2	232660931	232660931	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagggcaagctggaccagcGaaaccagctgctggaagtgg	15	11	0	0	rs147144693		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:232660931G>A	ENST00000373608.3	+	5	550	c.443G>A	c.(442-444)cGa>cAa	p.R148Q	COPS7B_ENST00000410024.1_Missense_Mutation_p.R148Q|COPS7B_ENST00000410017.1_Missense_Mutation_p.R148Q|COPS7B_ENST00000409295.1_Missense_Mutation_p.R114Q|COPS7B_ENST00000409091.1_Missense_Mutation_p.R41Q|COPS7B_ENST00000350033.3_Missense_Mutation_p.R148Q			Q9H9Q2	CSN7B_HUMAN	COP9 signalosome subunit 7B	148	PCI.				cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)	8		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CTGGACCAGCGAAACCAGCTG	0.483													31	33					0	0	1	0	0	A	232660931	G	A	232660931	3	1	48	1	0	0	0	0	1	0	0	0	3762	1058	37	1	457	1	COPS7B	2	232660931	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	338539	232660931	10538442	821	5215										
EFHD1	80303	broad.mit.edu	37	chr2	233498584	233498584	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgccgacgcggagctgagcgCccagctgagccggcggctgg	18	15	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:233498584C>T	ENST00000264059.3	+	1	647	c.170C>T	c.(169-171)gCc>gTc	p.A57V	EFHD1_ENST00000409613.1_Intron	NM_025202.3	NP_079478.1	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	57							calcium ion binding|protein binding			NS(1)|breast(1)|large_intestine(2)|lung(3)	7		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		GAGCTGAGCGCCCAGCTGAGC	0.771													5	9					0	0	1	0	0	T	233498584	C	T	233498584	3	4	48	1	0	0	0	0	1	0	0	0	4974	739	26	3	172	3	EFHD1	2	233498584	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	837653	233498584	9700789	822	5216										
UGT1A10	0	broad.mit.edu	37	chr2	234545624	234545624	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctggatccttttgatacCtgtggcttaattgttgctaa	8	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:234545624C>A	ENST00000344644.5	+	1	525	c.456C>A	c.(454-456)acC>acA	p.T152T	UGT1A10_ENST00000373445.1_Silent_p.T152T|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		CTTTTGATACCTGTGGCTTAA	0.408													39	91					7.61001e-30	1.08524e-29	1	1	0	A	234545624	C	A	234545624	2	1	48	1	0	0	0	0	0	0	0	1	17004	668	24	5		5	UGT1A10	2	234545624	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1047040	234545624	8653749	823	5217										
UGT1A9	0	broad.mit.edu	37	chr2	234580906	234580906	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgaagtatatattctctatTaatgggttcatacaatgaca	6	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:234580906T>G	ENST00000354728.4	+	1	408	c.326T>G	c.(325-327)tTa>tGa	p.L109*	UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TATTCTCTATTAATGGGTTCA	0.338													11	74					0	0	1	0	0	G	234580906	T	G	234580906	4	3	48	1	0	0	0	0	0	1	0	0	17011	1764	61	4	328	4	UGT1A9	2	234580906	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	35282	234580906	8618467	824	5218										
UGT1A5	0	broad.mit.edu	37	chr2	234621645	234621645	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttctgctgagatggccaCaggactccaggttcccctgc	12	14	1	1	rs150697955		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:234621645C>G	ENST00000373414.3	+	1	8	c.8C>G	c.(7-9)aCa>aGa	p.T3R	UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GAGATGGCCACAGGACTCCAG	0.587													29	56					0	0	1	0	0	G	234621645	C	G	234621645	3	3	48	1	0	0	0	0	1	0	0	0	17007	478	17	5	10	5	UGT1A5	2	234621645	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	40739	234621645	8577728	825	5219										
TRPM8	79054	broad.mit.edu	37	chr2	234878372	234878372	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaatggtatggagagattTcccgagacaccaagaactgg	12	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:234878372T>C	ENST00000324695.4	+	16	2099	c.2059T>C	c.(2059-2061)Tcc>Ccc	p.S687P	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	687						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGGAGAGATTTCCCGAGACAC	0.398													28	65					0	0	1	0	0	C	234878372	T	C	234878372	3	2	48	1	0	0	0	0	1	0	0	0	16652	1783	62	4	2117	4	TRPM8	2	234878372	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	256727	234878372	8321001	826	5220										
SH3BP4	23677	broad.mit.edu	37	chr2	235951498	235951498	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcgggtcaggctccggggCcagctgtggaccaaggagtg	19	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:235951498C>T	ENST00000409212.1	+	4	2592	c.2085C>T	c.(2083-2085)ggC>ggT	p.G695G	SH3BP4_ENST00000392011.2_Silent_p.G695G|SH3BP4_ENST00000344528.4_Silent_p.G695G			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	695					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GGCTCCGGGGCCAGCTGTGGA	0.652													8	85					0	0	1	0	0	T	235951498	C	T	235951498	2	4	48	1	0	0	0	0	0	0	0	1	14299	726	26	3		3	SH3BP4	2	235951498	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1073126	235951498	7247875	827	5221										
SH3BP4	23677	broad.mit.edu	37	chr2	235962357	235962357	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgaaaaaccccatcaccaAgcgctggaagcacctcactg	8	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:235962357A>C	ENST00000409212.1	+	6	3296	c.2789A>C	c.(2788-2790)aAg>aCg	p.K930T	SH3BP4_ENST00000392011.2_Missense_Mutation_p.K930T|SH3BP4_ENST00000344528.4_Missense_Mutation_p.K930T			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	930					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CCCATCACCAAGCGCTGGAAG	0.577													39	179					0	0	1	0	0	C	235962357	A	C	235962357	3	2	48	1	0	0	0	0	1	0	0	0	14299	72	3	4	2803	4	SH3BP4	2	235962357	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	10859	235962357	7237016	828	5222										
AGAP1	116987	broad.mit.edu	37	chr2	236792005	236792005	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagggcatgctgttgaagcGaagtggcaaatcgttgaata	14	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:236792005G>A	ENST00000409538.1	+	10	2358	c.1862G>A	c.(1861-1863)cGa>cAa	p.R621Q	AGAP1_ENST00000428334.2_Missense_Mutation_p.R195Q|AGAP1_ENST00000304032.7_Missense_Mutation_p.R356Q|AGAP1_ENST00000336665.5_Missense_Mutation_p.R356Q			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	356	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding	p.R356Q(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CTGTTGAAGCGAAGTGGCAAA	0.388													17	31					0	0	1	0	0	A	236792005	G	A	236792005	3	1	48	1	0	0	0	0	1	0	0	0	365	1058	37	1	1105	1	AGAP1	2	236792005	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	829648	236792005	6407368	829	5223										
COL6A3	1293	broad.mit.edu	37	chr2	238268776	238268776	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctggaaaccttgagtgccGttcacaccaggcggaccacg	11	15	1	1	rs34390834	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:238268776G>A	ENST00000295550.4	-	17	6689	c.6237C>T	c.(6235-6237)aaC>aaT	p.N2079N	COL6A3_ENST00000353578.4_Silent_p.N1873N|COL6A3_ENST00000347401.3_Silent_p.N1878N|COL6A3_ENST00000472056.1_Silent_p.N1472N|COL6A3_ENST00000346358.4_Silent_p.N1879N|COL6A3_ENST00000409809.1_Silent_p.N1873N	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2079	Collagen-like 1.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTTGAGTGCCGTTCACACCAG	0.612													20	31					0	0	1	0	0	A	238268776	G	A	238268776	2	1	48	1	0	0	0	0	0	0	0	1	3724	1136	40	1		1	COL6A3	2	238268776	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1476771	238268776	4930597	830	5224										
COL6A3	1293	broad.mit.edu	37	chr2	238277715	238277715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggggccgatgttgagtcttCgaacaatcctgctaacaaaa	10	9	1	1	rs138676768		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:238277715C>T	ENST00000295550.4	-	10	4843	c.4391G>A	c.(4390-4392)cGa>cAa	p.R1464Q	COL6A3_ENST00000353578.4_Missense_Mutation_p.R1258Q|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1263Q|COL6A3_ENST00000472056.1_Missense_Mutation_p.R857Q|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1264Q|COL6A3_ENST00000409809.1_Missense_Mutation_p.R1258Q	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1464	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTTGAGTCTTCGAACAATCCT	0.478													7	30					0	0	1	0	0	T	238277715	C	T	238277715	3	4	48	1	0	0	0	0	1	0	0	0	3724	884	31	1	5282	1	COL6A3	2	238277715	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8939	238277715	4921658	831	5225										
COL6A3	1293	broad.mit.edu	37	chr2	238285704	238285704	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgccagcagacttcacaaaAatgtacctctgtgcatagtc	7	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:238285704A>C	ENST00000295550.4	-	7	3233	c.2781T>G	c.(2779-2781)atT>atG	p.I927M	COL6A3_ENST00000392003.2_Missense_Mutation_p.I520M|COL6A3_ENST00000353578.4_Missense_Mutation_p.I721M|COL6A3_ENST00000347401.3_Missense_Mutation_p.I726M|COL6A3_ENST00000472056.1_Missense_Mutation_p.I320M|COL6A3_ENST00000392004.3_Missense_Mutation_p.I721M|COL6A3_ENST00000346358.4_Missense_Mutation_p.I727M|COL6A3_ENST00000409809.1_Missense_Mutation_p.I721M	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	927	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACTTCACAAAAATGTACCTCT	0.537													8	80					0	0	1	0	0	C	238285704	A	C	238285704	3	2	48	1	0	0	0	0	1	0	0	0	3724	10	1	4	6951	4	COL6A3	2	238285704	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7989	238285704	4913669	832	5226										
LRRFIP1	9208	broad.mit.edu	37	chr2	238662113	238662113	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaggcggcagtacgaagaGaaaaacaaagtaagcattag	11	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:238662113G>T	ENST00000244815.5	+	7	813	c.573G>T	c.(571-573)gaG>gaT	p.E191D	LRRFIP1_ENST00000308482.9_Missense_Mutation_p.E343D|LRRFIP1_ENST00000392000.4_Missense_Mutation_p.E215D|LRRFIP1_ENST00000289175.6_Missense_Mutation_p.E159D	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	215					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		AGTACGAAGAGAAAAACAAAG	0.438													17	60					3.32936e-07	3.80431e-07	1	1	0	T	238662113	G	T	238662113	3	4	48	1	0	0	0	0	1	0	0	0	9071	933	33	2	1157	2	LRRFIP1	2	238662113	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	376409	238662113	4537260	833	5227										
RBM44	375316	broad.mit.edu	37	chr2	238725726	238725726	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttcctgatgatgactggaAttcttcgacactagagcaaa	8	8	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:238725726A>C	ENST00000316997.4	+	3	299	c.167A>C	c.(166-168)aAt>aCt	p.N56T	RBM44_ENST00000444524.2_Intron|RBM44_ENST00000409864.1_Missense_Mutation_p.N56T	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	55							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		GATGACTGGAATTCTTCGACA	0.308													15	40					0	0	1	0	0	C	238725726	A	C	238725726	3	2	48	1	0	0	0	0	1	0	0	0	13189	101	4	4	173	4	RBM44	2	238725726	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	63613	238725726	4473647	834	5228										
KLHL30	377007	broad.mit.edu	37	chr2	239049878	239049878	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggccttcctgcgagagaaCtttgaggctgtggcacgtga	15	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:239049878C>A	ENST00000409223.1	+	2	590	c.483C>A	c.(481-483)aaC>aaA	p.N161K	KLHL30_ENST00000305959.4_Missense_Mutation_p.N143K			Q0D2K2	KLH30_HUMAN	kelch-like family member 30	161	BACK.									lung(4)	4		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TGCGAGAGAACTTTGAGGCTG	0.642													4	27					0.00024832	0.000265255	1	1	0	A	239049878	C	A	239049878	3	1	48	1	0	0	0	0	1	0	0	0	8426	564	20	5	485	5	KLHL30	2	239049878	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	324152	239049878	4149495	835	5229										
ILKAP	80895	broad.mit.edu	37	chr2	239093869	239093869	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgcaaattctgtgcagcaAattttgaggctcgaattcct	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:239093869A>C	ENST00000254654.3	-	6	660	c.485T>G	c.(484-486)tTt>tGt	p.F162C		NM_030768.2	NP_110395.1	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated serine/threonine phosphatase	162	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		CTGTGCAGCAAATTTTGAGGC	0.353													12	16					0	0	1	0	0	C	239093869	A	C	239093869	3	2	48	1	0	0	0	0	1	0	0	0	7757	14	1	4	721	4	ILKAP	2	239093869	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	43991	239093869	4105504	836	5230										
PER2	8864	broad.mit.edu	37	chr2	239174207	239174207	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgggtggttgtaaaaattCtcttttcaggaggaattcta	10	4	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:239174207C>A	ENST00000254657.3	-	9	1271	c.992G>T	c.(991-993)aGa>aTa	p.R331I	PER2_ENST00000254658.3_Missense_Mutation_p.R331I|PER2_ENST00000355768.2_Missense_Mutation_p.R331I|PER2_ENST00000440245.1_Missense_Mutation_p.R331I	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	331	PAS 2.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGTAAAAATTCTCTTTTCAGG	0.358													19	41					2.27731e-05	2.49859e-05	1	1	0	A	239174207	C	A	239174207	3	1	48	1	0	0	0	0	1	0	0	0	11776	913	32	2	2835	2	PER2	2	239174207	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80338	239174207	4025166	837	5231										
MYEOV2	150678	broad.mit.edu	37	chr2	241066116	241066116	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctgtcttcgctgacctctCgcctgcttcttgtggttctg	10	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:241066116C>T	ENST00000307266.3	-	5	622	c.623G>A	c.(622-624)cGa>cAa	p.R208Q		NM_138336.1	NP_612209.1	Q8WXC6	MYOV2_HUMAN	myeloma overexpressed 2	0										breast(1)|lung(5)|pancreas(1)	7		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		GCTGACCTCTCGCCTGCTTCT	0.478													27	87					0	0	1	0	0	T	241066116	C	T	241066116	3	4	48	1	0	0	0	0	1	0	0	0	10073	884	31	1	139	1	MYEOV2	2	241066116	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1891909	241066116	2133257	838	5232										
KIF1A	547	broad.mit.edu	37	chr2	241660374	241660374	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccttcaaccagagaggggcAagtggaggagggggtgagag	19	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:241660374A>G	ENST00000498729.2	-	45	5071	c.4825T>C	c.(4825-4827)Tgc>Cgc	p.C1609R	KIF1A_ENST00000320389.7_Missense_Mutation_p.C1508R	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1508	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AGAGAGGGGCAAGTGGAGGAG	0.647													9	11					0	0	1	0	0	G	241660374	A	G	241660374	3	3	48	1	0	0	0	0	1	0	0	0	8324	130	5	4	570	4	KIF1A	2	241660374	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	594258	241660374	1538999	839	5233										
KIF1A	547	broad.mit.edu	37	chr2	241661294	241661294	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatgtgtgcgtgagcaggCgcaagcactgtggacagagc	16	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:241661294C>T	ENST00000498729.2	-	44	4919	c.4673G>A	c.(4672-4674)cGc>cAc	p.R1558H	KIF1A_ENST00000320389.7_Missense_Mutation_p.R1457H	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1457					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CGTGAGCAGGCGCAAGCACTG	0.647													11	18					0	0	1	0	0	T	241661294	C	T	241661294	3	4	48	1	0	0	0	0	1	0	0	0	8324	768	27	1	726	1	KIF1A	2	241661294	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	920	241661294	1538079	840	5234										
PASK	23178	broad.mit.edu	37	chr2	242066686	242066686	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgggactggagcttcagaAtcttcgcaggaagcaaatgg	14	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:242066686A>C	ENST00000403638.3	-	10	1735	c.1644T>G	c.(1642-1644)gaT>gaG	p.D548E	PASK_ENST00000544142.1_Missense_Mutation_p.D362E|PASK_ENST00000539818.1_Missense_Mutation_p.D332E|PASK_ENST00000234040.4_Missense_Mutation_p.D548E|PASK_ENST00000405260.1_Missense_Mutation_p.D548E|PASK_ENST00000358649.4_Missense_Mutation_p.D548E	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	548					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GAGCTTCAGAATCTTCGCAGG	0.572													93	148					0	0	1	0	0	C	242066686	A	C	242066686	3	2	48	1	0	0	0	0	1	0	0	0	11518	98	4	4	2363	4	PASK	2	242066686	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	405392	242066686	1132687	841	5235										
PASK	23178	broad.mit.edu	37	chr2	242079418	242079418	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagcttctggccaatcaggTcctggctgctgtaccccagg	12	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:242079418T>C	ENST00000403638.3	-	4	573	c.482A>G	c.(481-483)gAc>gGc	p.D161G	PASK_ENST00000544142.1_Intron|PASK_ENST00000539818.1_Intron|PASK_ENST00000234040.4_Missense_Mutation_p.D161G|PASK_ENST00000405260.1_Missense_Mutation_p.D161G|PASK_ENST00000358649.4_Missense_Mutation_p.D161G	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	161	PAS 1.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCCAATCAGGTCCTGGCTGCT	0.587													14	20					0	0	1	0	0	C	242079418	T	C	242079418	3	2	48	1	0	0	0	0	1	0	0	0	11518	1667	58	4	3549	4	PASK	2	242079418	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	12732	242079418	1119955	842	5236										
PASK	23178	broad.mit.edu	37	chr2	242079939	242079939	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagagaagcaaatacctcTgtggtcttggcatccaccgt	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:242079939T>G	ENST00000403638.3	-	3	517	c.426A>C	c.(424-426)acA>acC	p.T142T	PASK_ENST00000544142.1_Intron|PASK_ENST00000539818.1_Intron|PASK_ENST00000234040.4_Silent_p.T142T|PASK_ENST00000405260.1_Silent_p.T142T|PASK_ENST00000358649.4_Silent_p.T142T	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	142	PAS 1.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CAAATACCTCTGTGGTCTTGG	0.498													4	10					0	0	1	0	0	G	242079939	T	G	242079939	2	3	48	1	0	0	0	0	0	0	0	1	11518	1567	55	4		4	PASK	2	242079939	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	521	242079939	1119434	843	5237										
SEPT2	4735	broad.mit.edu	37	chr2	242274562	242274562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatcaggtctaggaaaatCgactctcataaacagcctat	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:242274562C>T	ENST00000391973.2	+	4	680	c.152C>T	c.(151-153)tCg>tTg	p.S51L	SEPT2_ENST00000391971.2_Missense_Mutation_p.S51L|SEPT2_ENST00000401990.1_Missense_Mutation_p.S51L|SEPT2_ENST00000360051.3_Missense_Mutation_p.S51L|SEPT2_ENST00000402092.2_Missense_Mutation_p.S51L|SEPT2_ENST00000407971.1_Missense_Mutation_p.S11L	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	51					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		CTAGGAAAATCGACTCTCATA	0.363													8	8					0	0	1	0	0	T	242274562	C	T	242274562	3	4	48	1	0	0	0	0	1	0	0	0	14117	893	31	1	162	1	SEPT2	2	242274562	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	194623	242274562	924811	844	5238										
PDCD1	5133	broad.mit.edu	37	chr2	242795030	242795030	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtttagcacgaagctctccGatgtgttggagaagctgcag	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr2:242795030G>A	ENST00000334409.5	-	2	248	c.179C>T	c.(178-180)tCg>tTg	p.S60L		NM_005018.2	NP_005009.2	Q15116	PDCD1_HUMAN	programmed cell death 1	60	Ig-like V-type.				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			endometrium(1)|lung(2)|ovary(1)|prostate(3)|skin(1)	8		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GAAGCTCTCCGATGTGTTGGA	0.657													14	26					0	0	1	0	0	A	242795030	G	A	242795030	3	1	48	1	0	0	0	0	1	0	0	0	11661	1059	37	1	703	1	PDCD1	2	242795030	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	520468	242795030	404343	845	5239										
CHL1	10752	broad.mit.edu	37	chr3	391106	391106	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaggggagagaaacaaaaGaaaattatggcaagactttg	11	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:391106G>T	ENST00000256509.2	+	10	1555	c.913G>T	c.(913-915)Gaa>Taa	p.E305*	CHL1_ENST00000397491.2_Nonsense_Mutation_p.E289*	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	289	Ig-like C2-type 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGAAACAAAAGAAAATTATGG	0.383													18	35					1.99824e-07	2.29918e-07	1	1	0	T	391106	G	T	391106	4	4	48	1	0	0	0	0	0	1	0	0	3371	943	33	2	943	2	CHL1	3	391106	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		391106	197631324	846	5240										
CHL1	10752	broad.mit.edu	37	chr3	424189	424189	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatttgaaggaaacaaagaaGagcctggaaggtgggaggaa	15	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:424189G>T	ENST00000256509.2	+	18	2653	c.2011G>T	c.(2011-2013)Gag>Tag	p.E671*	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Nonsense_Mutation_p.E655*	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	655	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAACAAAGAAGAGCCTGGAAG	0.373													30	86					1.30988e-24	1.84044e-24	1	1	0	T	424189	G	T	424189	4	4	48	1	0	0	0	0	0	1	0	0	3371	943	33	2	2073	2	CHL1	3	424189	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	33083	424189	197598241	847	5241										
CNTN4	152330	broad.mit.edu	37	chr3	3097838	3097838	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatctggggcttccacttcGaatgcatgtacgctgtcagc	12	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:3097838G>A	ENST00000397461.1	+	24	3399	c.3015G>A	c.(3013-3015)tcG>tcA	p.S1005S	CNTN4_ENST00000397459.2_Silent_p.S677S|CNTN4_ENST00000418658.1_Silent_p.S1005S|CNTN4_ENST00000427331.1_Silent_p.S1005S|CNTN4_ENST00000358480.3_Silent_p.S786S|CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000448906.2_Silent_p.S677S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	1005					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CTTCCACTTCGAATGCATGTA	0.463													12	30					0	0	1	0	0	A	3097838	G	A	3097838	2	1	48	1	0	0	0	0	0	0	0	1	3666	1045	37	1		1	CNTN4	3	3097838	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2673649	3097838	194924592	848	5242										
ITPR1	3708	broad.mit.edu	37	chr3	4854917	4854917	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctctcctgcacccagagaAggtaggacctcctaactgta	8	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:4854917A>C	ENST00000302640.8	+	56	7865	c.7516_splice	c.e56+1	p.E2505_splice	ITPR1_ENST00000357086.4_Splice_Site_p.E2472_splice|ITPR1_ENST00000544951.1_Splice_Site_p.E483_splice|ITPR1_ENST00000463980.1_3'UTR|ITPR1_ENST00000354582.6_Splice_Site_p.E2505_splice|ITPR1_ENST00000456211.2_Splice_Site_p.E2457_splice|ITPR1_ENST00000443694.2_Splice_Site_p.E2505_splice|ITPR1_ENST00000423119.2_Splice_Site_p.E2472_splice	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2520	Interaction with ERP44 (By similarity).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CACCCAGAGAAGGTAGGACCT	0.517													8	79					0	0	1	0	0	C	4854917	A	C	4854917	5	2	48	1	0	0	0	0	0	0	1	0	7963	86	3	4	7778	4	ITPR1	3	4854917	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1757079	4854917	193167513	849	5243										
EDEM1	9695	broad.mit.edu	37	chr3	5255095	5255095	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgtggatgagcatcttcGggaattgccatggaaggaat	13	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:5255095G>A	ENST00000256497.4	+	11	1905	c.1772G>A	c.(1771-1773)cGg>cAg	p.R591Q		NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	591					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GAGCATCTTCGGGAATTGCCA	0.473													9	19					0	0	1	0	0	A	5255095	G	A	5255095	3	1	48	1	0	0	0	0	1	0	0	0	4937	1116	39	1	1814	1	EDEM1	3	5255095	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	400178	5255095	192767335	850	5244										
GRM7	2917	broad.mit.edu	37	chr3	7494314	7494314	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaggagagaattggaaaaGattccaactatgagcaggag	13	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:7494314G>T	ENST00000486284.1	+	6	1469	c.1195G>T	c.(1195-1197)Gat>Tat	p.D399Y	GRM7_ENST00000402647.2_Missense_Mutation_p.D399Y|GRM7_ENST00000357716.4_Missense_Mutation_p.D399Y|GRM7_ENST00000403881.1_Missense_Mutation_p.D399Y|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000389336.4_Missense_Mutation_p.D399Y	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	399					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.D399Y(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AATTGGAAAAGATTCCAACTA	0.433													11	51					3.07112e-06	3.42433e-06	1	1	0	T	7494314	G	T	7494314	3	4	48	1	0	0	0	0	1	0	0	0	6842	942	33	2	1217	2	GRM7	3	7494314	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2239219	7494314	190528116	851	5245										
GRM7	2917	broad.mit.edu	37	chr3	7620981	7620981	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attggattcactatgtacacGacatgtatagtatggcttgc	9	7	1	0	rs117160055		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:7620981G>A	ENST00000486284.1	+	8	2662	c.2388G>A	c.(2386-2388)acG>acA	p.T796T	GRM7_ENST00000402647.2_Silent_p.T796T|GRM7_ENST00000357716.4_Silent_p.T796T|GRM7_ENST00000403881.1_Silent_p.T796T|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000389336.4_Silent_p.T796T	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	796					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CTATGTACACGACATGTATAG	0.403													15	20					0	0	1	0	0	A	7620981	G	A	7620981	2	1	48	1	0	0	0	0	0	0	0	1	6842	1045	37	1		1	GRM7	3	7620981	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	126667	7620981	190401449	852	5246										
OXTR	5021	broad.mit.edu	37	chr3	8809319	8809319	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaagacggcccagcagtcGaagacgccgtcagccacctc	11	15	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:8809319G>A	ENST00000316793.3	-	3	1179	c.555C>T	c.(553-555)ttC>ttT	p.F185F	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	185					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	CCCAGCAGTCGAAGACGCCGT	0.662													43	54					0	0	1	0	0	A	8809319	G	A	8809319	2	1	48	1	0	0	0	0	0	0	0	1	11384	1049	37	1		1	OXTR	3	8809319	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1188338	8809319	189213111	853	5247										
RAD18	56852	broad.mit.edu	37	chr3	8981263	8981263	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggctttccttcttctcttCgcgtgataaacagctgtcta	8	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:8981263C>T	ENST00000264926.2	-	6	795	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K		NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	227					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		TTCTTCTCTTCGCGTGATAAA	0.403								Rad6 pathway					12	46					0	0	1	0	0	T	8981263	C	T	8981263	3	4	48	1	0	0	0	0	1	0	0	0	13031	893	31	1	840	1	RAD18	3	8981263	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	171944	8981263	189041167	854	5248										
SETD5	55209	broad.mit.edu	37	chr3	9489440	9489440	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggccccggccgaagagtcGaatttctcggtacaggacca	12	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:9489440G>A	ENST00000402466.1	+	16	2327	c.1559G>A	c.(1558-1560)cGa>cAa	p.R520Q	SETD5_ENST00000402198.1_Missense_Mutation_p.R618Q|SETD5_ENST00000406341.1_Missense_Mutation_p.R618Q|SETD5_ENST00000407969.1_Missense_Mutation_p.R637Q|SETD5_ENST00000302463.6_Missense_Mutation_p.R520Q|SETD5_ENST00000488236.1_3'UTR			Q9C0A6	SETD5_HUMAN	SET domain containing 5	618								p.R520L(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CCGAAGAGTCGAATTTCTCGG	0.522													46	103					0	0	1	0	0	A	9489440	G	A	9489440	3	1	48	1	0	0	0	0	1	0	0	0	14187	1058	37	1	1903	1	SETD5	3	9489440	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	508177	9489440	188532990	855	5249										
RPUSD3	285367	broad.mit.edu	37	chr3	9883747	9883747	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggcagcactgagaacaaCgtcagctctcctggttttcc	9	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:9883747C>T	ENST00000383820.5	-	4	328	c.327G>A	c.(325-327)acG>acA	p.T109T	TTLL3_ENST00000455274.1_Intron|RPUSD3_ENST00000424438.1_Silent_p.T77T|RPUSD3_ENST00000485705.1_5'UTR|RPUSD3_ENST00000433535.2_Silent_p.T94T	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	109					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					CTGAGAACAACGTCAGCTCTC	0.522													72	94					0	0	1	0	0	T	9883747	C	T	9883747	2	4	48	1	0	0	0	0	0	0	0	1	13719	523	19	1		1	RPUSD3	3	9883747	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	394307	9883747	188138683	856	5250										
TATDN2	9797	broad.mit.edu	37	chr3	10311962	10311962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccttcttccttcaccaccGactatgtcatgtaccctcct	4	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:10311962G>A	ENST00000287652.4	+	4	2147	c.1096G>A	c.(1096-1098)Gac>Aac	p.D366N	RP11-438J1.1_ENST00000450534.1_3'UTR|TATDN2_ENST00000448281.2_Missense_Mutation_p.D366N	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	366						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						CTTCACCACCGACTATGTCAT	0.537													56	93					0	0	1	0	0	A	10311962	G	A	10311962	3	1	48	1	0	0	0	0	1	0	0	0	15648	1058	37	1	1106	1	TATDN2	3	10311962	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	428215	10311962	187710468	857	5251										
SLC6A11	6538	broad.mit.edu	37	chr3	10970992	10970992	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcctagccttgtctgttatCtcctattttctgggcctcgt	7	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:10970992C>A	ENST00000254488.2	+	10	1404	c.1338C>A	c.(1336-1338)atC>atA	p.I446I		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	446					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TGTCTGTTATCTCCTATTTTC	0.567													42	82					8.69298e-16	1.14932e-15	1	1	0	A	10970992	C	A	10970992	2	1	48	1	0	0	0	0	0	0	0	1	14728	903	32	2		2	SLC6A11	3	10970992	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	659030	10970992	187051438	858	5252										
SLC6A1	6529	broad.mit.edu	37	chr3	11064023	11064023	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctccactgtttgaccaggCgcaacatgcatcagatgacg	9	14	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:11064023C>T	ENST00000287766.4	+	7	1004	c.581_splice	c.e7-1	p.R195_splice	SLC6A1_ENST00000536032.1_Splice_Site_p.R17_splice	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	195					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TTTGACCAGGCGCAACATGCA	0.602													13	29					0	0	1	0	0	T	11064023	C	T	11064023	5	4	48	1	0	0	0	0	0	0	1	0	14727	782	27	1	601	1	SLC6A1	3	11064023	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93031	11064023	186958407	859	5253										
TSEN2	80746	broad.mit.edu	37	chr3	12531417	12531417	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctgaaagaattcaagataTtccgtgctgaaatgattaac	7	7	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:12531417T>G	ENST00000444864.1	+	2	505	c.118T>G	c.(118-120)Ttc>Gtc	p.F40V	TSEN2_ENST00000454502.2_Missense_Mutation_p.F40V|TSEN2_ENST00000415684.1_Missense_Mutation_p.F40V|TSEN2_ENST00000402228.3_Missense_Mutation_p.F40V|TSEN2_ENST00000383797.5_Missense_Mutation_p.F40V|TSEN2_ENST00000314571.7_Missense_Mutation_p.F40V|TSEN2_ENST00000284995.6_Missense_Mutation_p.F40V	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	40					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						ATTCAAGATATTCCGTGCTGA	0.448													33	48					0	0	1	0	0	G	12531417	T	G	12531417	3	3	48	1	0	0	0	0	1	0	0	0	16672	1493	52	4	120	4	TSEN2	3	12531417	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1467394	12531417	185491013	860	5254										
TSEN2	80746	broad.mit.edu	37	chr3	12544934	12544934	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctggaatggtttccaacaTggaaggcacagcagggggag	15	8	1	0	rs36084365		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:12544934T>C	ENST00000444864.1	+	5	869	c.482T>C	c.(481-483)aTg>aCg	p.M161T	TSEN2_ENST00000454502.2_Missense_Mutation_p.M161T|TSEN2_ENST00000415684.1_Missense_Mutation_p.M161T|TSEN2_ENST00000402228.3_Missense_Mutation_p.M161T|TSEN2_ENST00000383797.5_Missense_Mutation_p.M161T|TSEN2_ENST00000314571.7_Missense_Mutation_p.M161T|TSEN2_ENST00000284995.6_Missense_Mutation_p.M161T	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	161					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						GTTTCCAACATGGAAGGCACA	0.522													12	44					0	0	1	0	0	C	12544934	T	C	12544934	3	2	48	1	0	0	0	0	1	0	0	0	16672	1464	51	4	496	4	TSEN2	3	12544934	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	13517	12544934	185477496	861	5255										
TSEN2	80746	broad.mit.edu	37	chr3	12571276	12571276	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagttattctgtcattatCgagctagttgatgaccattt	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:12571276C>T	ENST00000444864.1	+	9	1461	c.1074C>T	c.(1072-1074)atC>atT	p.I358I	C3orf83_ENST00000567514.1_Intron|TSEN2_ENST00000454502.2_Silent_p.I325I|TSEN2_ENST00000415684.1_Silent_p.I358I|TSEN2_ENST00000402228.3_Silent_p.I384I|TSEN2_ENST00000383797.5_Silent_p.I367I|TSEN2_ENST00000314571.7_Silent_p.I358I|TSEN2_ENST00000284995.6_Silent_p.I384I	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	384					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						CTGTCATTATCGAGCTAGTTG	0.373													19	34					0	0	1	0	0	T	12571276	C	T	12571276	2	4	48	1	0	0	0	0	0	0	0	1	16672	874	31	1		1	TSEN2	3	12571276	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	26342	12571276	185451154	862	5256										
CAND2	23066	broad.mit.edu	37	chr3	12858428	12858428	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcctgcggaagaaccagcGggctttgcgactggccacac	12	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:12858428G>A	ENST00000456430.2	+	10	2038	c.1997G>A	c.(1996-1998)cGg>cAg	p.R666Q	CAND2_ENST00000295989.5_Missense_Mutation_p.R573Q	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	666					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AAGAACCAGCGGGCTTTGCGA	0.667													43	58					0	0	1	0	0	A	12858428	G	A	12858428	3	1	48	1	0	0	0	0	1	0	0	0	2634	1116	39	1	2035	1	CAND2	3	12858428	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	287152	12858428	185164002	863	5257										
NUP210	23225	broad.mit.edu	37	chr3	13420466	13420466	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgggtaacctagaagcacCttgcatgcgaatacctgaat	10	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:13420466C>A	ENST00000254508.5	-	8	1073	c.991G>T	c.(991-993)Ggt>Tgt	p.G331C		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	331					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CTAGAAGCACCTTGCATGCGA	0.498													28	46					1.5548e-18	2.10666e-18	1	1	0	A	13420466	C	A	13420466	3	1	48	1	0	0	0	0	1	0	0	0	10807	681	24	5	4804	5	NUP210	3	13420466	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	562038	13420466	184601964	864	5258										
TMEM43	79188	broad.mit.edu	37	chr3	14172445	14172445	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacatcattggcgccttaCggacatccaaggtaggtttg	11	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:14172445C>T	ENST00000306077.4	+	3	540	c.286C>T	c.(286-288)Cgg>Tgg	p.R96W		NM_024334.2	NP_077310.1	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	96						endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				breast(1)|cervix(3)|endometrium(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(2)	19						TGGCGCCTTACGGACATCCAA	0.582													12	66					0	0	1	0	0	T	14172445	C	T	14172445	3	4	48	1	0	0	0	0	1	0	0	0	16226	527	19	1	296	1	TMEM43	3	14172445	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	751979	14172445	183849985	865	5259										
C3orf20	84077	broad.mit.edu	37	chr3	14724344	14724344	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcatttctgtaccaaaaGgcatcagaaacatctttgag	8	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:14724344G>T	ENST00000253697.3	+	3	576	c.124G>T	c.(124-126)Ggc>Tgc	p.G42C	C3orf20_ENST00000412910.1_Intron|C3orf20_ENST00000435614.1_Intron	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	42			G -> D (in dbSNP:rs17040154).			cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						TGTACCAAAAGGCATCAGAAA	0.512													26	92					1.16021e-09	1.40238e-09	1	1	0	T	14724344	G	T	14724344	3	4	48	1	0	0	0	0	1	0	0	0	2227	1000	35	5	126	5	C3orf20	3	14724344	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	551899	14724344	183298086	866	5260										
C3orf20	84077	broad.mit.edu	37	chr3	14745900	14745900	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctaccccatgatcttacGaaactacaaggcaaagatgc	6	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:14745900G>A	ENST00000253697.3	+	7	1387	c.935G>A	c.(934-936)cGa>cAa	p.R312Q	C3orf20_ENST00000412910.1_Missense_Mutation_p.R190Q|C3orf20_ENST00000495387.1_3'UTR|C3orf20_ENST00000435614.1_Missense_Mutation_p.R190Q	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	312						cytoplasm|integral to membrane		p.R312Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						ATGATCTTACGAAACTACAAG	0.493													32	51					0	0	1	0	0	A	14745900	G	A	14745900	3	1	48	1	0	0	0	0	1	0	0	0	2227	1058	37	1	953	1	C3orf20	3	14745900	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	21556	14745900	183276530	867	5261										
CAPN7	23473	broad.mit.edu	37	chr3	15275456	15275456	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaactttcagtaaggataAttctttcagaatgctttatc	5	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:15275456A>C	ENST00000253693.2	+	11	1515	c.1262A>C	c.(1261-1263)aAt>aCt	p.N421T		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	421	Calpain catalytic.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						AGTAAGGATAATTCTTTCAGA	0.383													19	32					0	0	1	0	0	C	15275456	A	C	15275456	3	2	48	1	0	0	0	0	1	0	0	0	2649	101	4	4	1304	4	CAPN7	3	15275456	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	529556	15275456	182746974	868	5262										
DPH3	285381	broad.mit.edu	37	chr3	16302288	16302288	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcagcatttaactaattCtttgttggctgaaggggctg	10	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:16302288C>A	ENST00000488423.1	-	3	327	c.232G>T	c.(232-234)Gaa>Taa	p.E78*	DPH3_ENST00000383775.4_Nonsense_Mutation_p.E53*|DPH3_ENST00000285082.4_5'UTR	NM_206831.2	NP_996662.1	Q96FX2	DPH3_HUMAN	diphthamide biosynthesis 3	78					negative regulation of protein secretion|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of binding	cytoplasm|nucleus	metal ion binding|protein binding			large_intestine(2)	2						TTAACTAATTCTTTGTTGGCT	0.413													7	13					0.00307968	0.00320271	1	1	0	A	16302288	C	A	16302288	4	1	48	1	0	0	0	0	0	1	0	0	4748	922	32	2	20	2	DPH3	3	16302288	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1026832	16302288	181720142	869	5263										
DAZL	1618	broad.mit.edu	37	chr3	16633591	16633591	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgagtaacaacagagtttCtcagtctgttctctggatta	8	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:16633591C>A	ENST00000250863.8	-	10	1147	c.860G>T	c.(859-861)aGa>aTa	p.R287I	DAZL_ENST00000399444.2_Missense_Mutation_p.R267I	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	267					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						AACAGAGTTTCTCAGTCTGTT	0.363													36	76					1.47197e-15	1.94065e-15	1	1	0	A	16633591	C	A	16633591	3	1	48	1	0	0	0	0	1	0	0	0	4270	913	32	2	95	2	DAZL	3	16633591	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	331303	16633591	181388839	870	5264										
PLCL2	23228	broad.mit.edu	37	chr3	17052807	17052807	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtgcttgccagcaagtacGccaatgaaaatccaggggac	11	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:17052807G>A	ENST00000418129.2	+	2	2056	c.1591G>A	c.(1591-1593)Gcc>Acc	p.A531T	PLCL2_ENST00000396755.2_Missense_Mutation_p.A531T|PLCL2_ENST00000432376.1_Missense_Mutation_p.A531T	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	657	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						CAGCAAGTACGCCAATGAAAA	0.403													38	78					0	0	1	0	0	A	17052807	G	A	17052807	3	1	48	1	0	0	0	0	1	0	0	0	12087	1087	38	1	1969	1	PLCL2	3	17052807	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	419216	17052807	180969623	871	5265										
TBC1D5	9779	broad.mit.edu	37	chr3	17279903	17279903	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattcaggggagcacctttgGcattggtcctgttaaaaaaa	10	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:17279903G>A	ENST00000253692.7	-	17	3004	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V	TBC1D5_ENST00000446818.2_Missense_Mutation_p.A447V|TBC1D5_ENST00000414318.2_5'UTR|TBC1D5_ENST00000429924.2_Missense_Mutation_p.A399V|TBC1D5_ENST00000429383.4_Missense_Mutation_p.A447V	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	447						intracellular	protein binding|Rab GTPase activator activity	p.A447G(1)		NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						AGCACCTTTGGCATTGGTCCT	0.383													6	18					0	0	1	0	0	A	17279903	G	A	17279903	3	1	48	1	0	0	0	0	1	0	0	0	15682	1203	42	3	1141	3	TBC1D5	3	17279903	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	227096	17279903	180742527	872	5266										
SATB1	6304	broad.mit.edu	37	chr3	18438680	18438680	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttgcttacccatcatatCttttgtcttcttgaaatgtt	4	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:18438680C>A	ENST00000338745.6	-	6	2476	c.742G>T	c.(742-744)Gat>Tat	p.D248Y	TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Missense_Mutation_p.D248Y|SATB1_ENST00000417717.2_Missense_Mutation_p.D248Y	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	248	Nuclear matrix targeting sequence (NMTS).				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding	p.D248Y(1)		NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						CCCATCATATCTTTTGTCTTC	0.368													17	44					9.16793e-09	1.08598e-08	1	1	0	A	18438680	C	A	18438680	3	1	48	1	0	0	0	0	1	0	0	0	13905	913	32	2	1573	2	SATB1	3	18438680	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1158777	18438680	179583750	873	5267										
SGOL1	151648	broad.mit.edu	37	chr3	20219833	20219833	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattccagaggaacatatttCctggttctgttaatgtatta	7	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:20219833C>T	ENST00000412997.1	-	4	697	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	SGOL1_ENST00000442720.1_Missense_Mutation_p.E116K|SGOL1_ENST00000437051.1_Missense_Mutation_p.E116K|SGOL1_ENST00000452020.1_Missense_Mutation_p.E116K|SGOL1_ENST00000383774.1_Missense_Mutation_p.E116K|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1_ENST00000429446.3_Missense_Mutation_p.E116K|SGOL1_ENST00000417364.1_Missense_Mutation_p.E116K|SGOL1_ENST00000421451.1_Missense_Mutation_p.E116K|SGOL1_ENST00000419233.2_Missense_Mutation_p.E116K|SGOL1_ENST00000306698.2_Missense_Mutation_p.E116K|SGOL1_ENST00000425061.1_Missense_Mutation_p.E116K|SGOL1_ENST00000263753.4_Missense_Mutation_p.E116K|SGOL1_ENST00000412868.1_Missense_Mutation_p.E116K|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000443724.1_Missense_Mutation_p.E116K	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	116	Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						GAACATATTTCCTGGTTCTGT	0.313													13	28					0	0	1	0	0	T	20219833	C	T	20219833	3	4	48	1	0	0	0	0	1	0	0	0	14269	864	30	3	1383	3	SGOL1	3	20219833	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1781153	20219833	177802597	874	5268										
ZNF385D	79750	broad.mit.edu	37	chr3	21552454	21552454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttctgcttatttttcatgGcttccagtgctttgagcttc	7	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:21552454G>A	ENST00000281523.2	-	4	856	c.338C>T	c.(337-339)gCc>gTc	p.A113V	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	113						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						ATTTTTCATGGCTTCCAGTGC	0.463													31	53					0	0	1	0	0	A	21552454	G	A	21552454	3	1	48	1	0	0	0	0	1	0	0	0	17934	1203	42	3	869	3	ZNF385D	3	21552454	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1332621	21552454	176469976	875	5269										
NR1D2	9975	broad.mit.edu	37	chr3	24018775	24018775	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggaaactctcattcgtgcActaaggaccttaataatgaa	7	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:24018775A>G	ENST00000312521.4	+	8	1924	c.1605A>G	c.(1603-1605)gcA>gcG	p.A535A	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117.3	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	535					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						TCATTCGTGCACTAAGGACCT	0.388													8	17					0	0	1	0	0	G	24018775	A	G	24018775	2	3	48	1	0	0	0	0	0	0	0	1	10663	146	6	4		4	NR1D2	3	24018775	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2466321	24018775	174003655	876	5270										
TOP2B	7155	broad.mit.edu	37	chr3	25661352	25661352	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagtaaatctaataaattaCcatggaattacaagtaagag	6	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:25661352C>A	ENST00000435706.2	-	23	3250		c.e23+1		TOP2B_ENST00000542520.1_Splice_Site|TOP2B_ENST00000264331.4_Splice_Site			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa						DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						TAATAAATTACCATGGAATTA	0.333													7	11					2.0095e-06	2.25447e-06	1	1	0	A	25661352	C	A	25661352	5	1	48	1	0	0	0	0	0	0	1	0	16426	521	18	5	1872	5	TOP2B	3	25661352	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1642577	25661352	172361078	877	5271										
LRRC3B	116135	broad.mit.edu	37	chr3	26751258	26751258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtgctttcattctgccaGtatgtgtcccaagggctgtc	10	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:26751258G>A	ENST00000396641.2	+	2	687	c.95G>A	c.(94-96)aGt>aAt	p.S32N	LRRC3B_ENST00000417744.1_Missense_Mutation_p.S32N|LRRC3B_ENST00000456208.2_Missense_Mutation_p.S32N	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	32						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						CATTCTGCCAGTATGTGTCCC	0.448													32	34					0	0	1	0	0	A	26751258	G	A	26751258	3	1	48	1	0	0	0	0	1	0	0	0	9040	1029	36	3	97	3	LRRC3B	3	26751258	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1089906	26751258	171271172	878	5272										
EOMES	8320	broad.mit.edu	37	chr3	27760902	27760902	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggtgagttttaatttcccGaatgaaatctcctgtctcat	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:27760902G>A	ENST00000295743.4	-	3	1310	c.1107C>T	c.(1105-1107)ttC>ttT	p.F369F	EOMES_ENST00000449599.1_Silent_p.F369F|EOMES_ENST00000537516.1_Silent_p.F74F|EOMES_ENST00000461503.1_5'UTR			O95936	EOMES_HUMAN	eomesodermin	369					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						TTAATTTCCCGAATGAAATCT	0.418													38	75					0	0	1	0	0	A	27760902	G	A	27760902	2	1	48	1	0	0	0	0	0	0	0	1	5175	1049	37	1		1	EOMES	3	27760902	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1009644	27760902	170261528	879	5273										
RBMS3	27303	broad.mit.edu	37	chr3	30032685	30032685	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaacatgcacctgcatattCttaccaacagtctaagtaag	6	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:30032685C>A	ENST00000434693.2	+	14	1989	c.1289C>A	c.(1288-1290)tCt>tAt	p.S430Y	RBMS3_ENST00000396583.3_Missense_Mutation_p.S428Y|RBMS3_ENST00000273139.9_Missense_Mutation_p.S415Y|RBMS3_ENST00000452462.1_Missense_Mutation_p.S415Y|RBMS3_ENST00000473799.1_3'UTR|RBMS3_ENST00000456853.1_Missense_Mutation_p.S428Y|RBMS3_ENST00000383766.2_Missense_Mutation_p.S413Y|RBMS3_ENST00000383767.2_Missense_Mutation_p.S431Y	NM_001003793.2	NP_001003793.1	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting protein 3	431						cytoplasm	nucleotide binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	11		Ovarian(412;0.0956)				CCTGCATATTCTTACCAACAG	0.478													4	73					2.56e-06	2.86294e-06	1	1	0	A	30032685	C	A	30032685	3	1	48	1	0	0	0	0	1	0	0	0	13201	913	32	2	1389	2	RBMS3	3	30032685	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2271783	30032685	167989745	880	5274										
GADL1	339896	broad.mit.edu	37	chr3	30885949	30885949	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaggctgccttcttcatagAgtaatgacactgaattcaaa	8	8	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:30885949A>C	ENST00000454381.3	-	7	707	c.661T>G	c.(661-663)Tct>Gct	p.S221A	GADL1_ENST00000282538.5_Missense_Mutation_p.S221A			Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	221					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	TTCTTCATAGAGTAATGACAC	0.428													41	64					0	0	1	0	0	C	30885949	A	C	30885949	3	2	48	1	0	0	0	0	1	0	0	0	6219	304	11	4	940	4	GADL1	3	30885949	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	853264	30885949	167136481	881	5275										
DCLK3	85443	broad.mit.edu	37	chr3	36779844	36779844	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggggcttgctactgggttCtggctcccatttccccctcc	12	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:36779844C>A	ENST00000416516.2	-	2	797	c.307G>T	c.(307-309)Gaa>Taa	p.E103*		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	103						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						CTACTGGGTTCTGGCTCCCAT	0.582													60	123					1.13205e-32	1.62219e-32	1	1	0	A	36779844	C	A	36779844	4	1	48	1	0	0	0	0	0	1	0	0	4316	922	32	2	1655	2	DCLK3	3	36779844	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5893895	36779844	161242586	882	5276										
TRANK1	9881	broad.mit.edu	37	chr3	36873394	36873394	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcacagcaccagtgtccgCtcagcctcacccgagaccac	8	18	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:36873394C>T	ENST00000429976.2	-	21	7795	c.7548G>A	c.(7546-7548)gaG>gaA	p.E2516E	TRANK1_ENST00000428977.2_Silent_p.E1966E|TRANK1_ENST00000301807.6_Silent_p.E1966E			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2516					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCAGTGTCCGCTCAGCCTCAC	0.527													42	98					0	0	1	0	0	T	36873394	C	T	36873394	2	4	48	1	0	0	0	0	0	0	0	1	16514	796	28	3		3	TRANK1	3	36873394	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93550	36873394	161149036	883	5277										
TRANK1	9881	broad.mit.edu	37	chr3	36874612	36874612	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcattatcaaaaaatgatcTtttgtttttttctctctcaa	3	7	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:36874612T>G	ENST00000429976.2	-	21	6577	c.6330A>C	c.(6328-6330)aaA>aaC	p.K2110N	TRANK1_ENST00000428977.2_Missense_Mutation_p.K1560N|TRANK1_ENST00000301807.6_Missense_Mutation_p.K1560N			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2110					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAAAATGATCTTTTGTTTTTT	0.418													4	8					0	0	1	0	0	G	36874612	T	G	36874612	3	3	48	1	0	0	0	0	1	0	0	0	16514	1606	56	4	2459	4	TRANK1	3	36874612	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1218	36874612	161147818	884	5278										
TRANK1	9881	broad.mit.edu	37	chr3	36875328	36875328	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttgcactcagatactttgCtgcagcttccaagtaaaact	6	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:36875328C>T	ENST00000429976.2	-	21	5861	c.5614G>A	c.(5614-5616)Gca>Aca	p.A1872T	TRANK1_ENST00000428977.2_Missense_Mutation_p.A1322T|TRANK1_ENST00000301807.6_Missense_Mutation_p.A1322T			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1872					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGATACTTTGCTGCAGCTTCC	0.433													33	65					0	0	1	0	0	T	36875328	C	T	36875328	3	4	48	1	0	0	0	0	1	0	0	0	16514	797	28	3	3175	3	TRANK1	3	36875328	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	716	36875328	161147102	885	5279										
TRANK1	9881	broad.mit.edu	37	chr3	36897168	36897168	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttagaaaagattttatttCtttccaaatcagtgcagggt	7	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:36897168C>A	ENST00000429976.2	-	12	4160	c.3913G>T	c.(3913-3915)Gaa>Taa	p.E1305*	TRANK1_ENST00000428977.2_Nonsense_Mutation_p.E755*|TRANK1_ENST00000301807.6_Nonsense_Mutation_p.E755*			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1305					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GATTTTATTTCTTTCCAAATC	0.458													16	114					2.23348e-06	2.50077e-06	1	1	0	A	36897168	C	A	36897168	4	1	48	1	0	0	0	0	0	1	0	0	16514	922	32	2	4912	2	TRANK1	3	36897168	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	21840	36897168	161125262	886	5280										
TRANK1	9881	broad.mit.edu	37	chr3	36897903	36897903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccagcaatgggcttcctgCctgctcagctttttcccagt	10	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:36897903C>T	ENST00000429976.2	-	12	3425	c.3178G>A	c.(3178-3180)Gca>Aca	p.A1060T	TRANK1_ENST00000428977.2_Missense_Mutation_p.A510T|TRANK1_ENST00000301807.6_Missense_Mutation_p.A510T			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1060					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GGGCTTCCTGCCTGCTCAGCT	0.527													14	25					0	0	1	0	0	T	36897903	C	T	36897903	3	4	48	1	0	0	0	0	1	0	0	0	16514	739	26	3	5647	3	TRANK1	3	36897903	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	735	36897903	161124527	887	5281										
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033157	37033157	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtccttaaaatgtctctcaAattctttttggagacgacag	8	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37033157A>C	ENST00000322716.5	-	1	1638	c.1412T>G	c.(1411-1413)tTt>tGt	p.F471C		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	471						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						ATGTCTCTCAAATTCTTTTTG	0.328													8	14					0	0	1	0	0	C	37033157	A	C	37033157	3	2	48	1	0	0	0	0	1	0	0	0	5212	14	1	4	415	4	EPM2AIP1	3	37033157	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	135254	37033157	160989273	888	5282										
LRRFIP2	9209	broad.mit.edu	37	chr3	37107798	37107798	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctaaggcaggcaatgtattCtttctgtttctctagggcct	9	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37107798C>A	ENST00000421307.1	-	23	1905	c.1483G>T	c.(1483-1485)Gaa>Taa	p.E495*	LRRFIP2_ENST00000396428.2_Intron|LRRFIP2_ENST00000336686.4_Nonsense_Mutation_p.E495*|LRRFIP2_ENST00000354379.4_Intron|LRRFIP2_ENST00000421276.2_Intron|LRRFIP2_ENST00000440230.1_Intron	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	495					Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						GCAATGTATTCTTTCTGTTTC	0.468													28	43					3.90053e-15	5.12206e-15	1	1	0	A	37107798	C	A	37107798	4	1	48	1	0	0	0	0	0	1	0	0	9072	922	32	2	710	2	LRRFIP2	3	37107798	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	74641	37107798	160914632	889	5283										
GOLGA4	2803	broad.mit.edu	37	chr3	37285051	37285051	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacgctgcgccatgttcaagAaactgaagcaaaagatcagc	9	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37285051A>G	ENST00000361924.2	+	1	384	c.10A>G	c.(10-12)Aaa>Gaa	p.K4E	GOLGA4_ENST00000435830.2_3'UTR|GOLGA4_ENST00000444882.1_Missense_Mutation_p.K4E|GOLGA4_ENST00000356847.4_Missense_Mutation_p.K4E|RP11-259K5.2_ENST00000604992.1_RNA	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	4					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CATGTTCAAGAAACTGAAGCA	0.617													21	45					0	0	1	0	0	G	37285051	A	G	37285051	3	3	48	1	0	0	0	0	1	0	0	0	6596	247	9	4	12	4	GOLGA4	3	37285051	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	177253	37285051	160737379	890	5284										
GOLGA4	2803	broad.mit.edu	37	chr3	37365881	37365881	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttggatttggaaacagaaaGaattcttcttaccaaacagg	9	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37365881G>T	ENST00000361924.2	+	14	2878	c.2504G>T	c.(2503-2505)aGa>aTa	p.R835I	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R857I	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	835	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GAAACAGAAAGAATTCTTCTT	0.413													34	83					1.62565e-12	2.05093e-12	1	1	0	T	37365881	G	T	37365881	3	4	48	1	0	0	0	0	1	0	0	0	6596	942	33	2	2628	2	GOLGA4	3	37365881	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	80830	37365881	160656549	891	5285										
GOLGA4	2803	broad.mit.edu	37	chr3	37368058	37368058	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaggatattgaacacaaaGaattggttcagaaacttcaa	7	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37368058G>T	ENST00000361924.2	+	14	5055	c.4681G>T	c.(4681-4683)Gaa>Taa	p.E1561*	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Nonsense_Mutation_p.E1583*	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1561	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding	p.E1561*(2)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TGAACACAAAGAATTGGTTCA	0.308													37	63					2.75727e-19	3.7504e-19	1	1	0	T	37368058	G	T	37368058	4	4	48	1	0	0	0	0	0	1	0	0	6596	943	33	2	4805	2	GOLGA4	3	37368058	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2177	37368058	160654372	892	5286										
C3orf35	339883	broad.mit.edu	37	chr3	37458846	37458846	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagaggttattgtgcgcccGaacttttcacacaagaattg	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37458846G>A	ENST00000328376.5	+	5	1068	c.89G>A	c.(88-90)cGa>cAa	p.R30Q	C3orf35_ENST00000426078.1_Missense_Mutation_p.R30Q|C3orf35_ENST00000481400.1_Intron|C3orf35_ENST00000425932.1_Missense_Mutation_p.R30Q|C3orf35_ENST00000425564.2_Missense_Mutation_p.R30Q|C3orf35_ENST00000452017.2_Missense_Mutation_p.R30Q	NM_178339.2	NP_848029.2	Q8IVJ8	APRG1_HUMAN	chromosome 3 open reading frame 35	30						integral to membrane				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	11						TTGTGCGCCCGAACTTTTCAC	0.433													42	88					0	0	1	0	0	A	37458846	G	A	37458846	3	1	48	1	0	0	0	0	1	0	0	0	2239	1058	37	1	91	1	C3orf35	3	37458846	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	90788	37458846	160563584	893	5287										
ITGA9	3680	broad.mit.edu	37	chr3	37821468	37821468	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgctaaagaagaaagtcgtActatagacatttacatgctg	8	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:37821468A>G	ENST00000264741.5	+	25	2999	c.2743A>G	c.(2743-2745)Act>Gct	p.T915A	AC093415.2_ENST00000438136.1_RNA	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	915					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AGAAAGTCGTACTATAGACAT	0.373													25	48					0	0	1	0	0	G	37821468	A	G	37821468	3	3	48	1	0	0	0	0	1	0	0	0	7926	391	14	4	2841	4	ITGA9	3	37821468	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	362622	37821468	160200962	894	5288										
DLEC1	9940	broad.mit.edu	37	chr3	38163210	38163210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctttgtgagccagcagcGagtccgggaggtctacctga	14	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:38163210G>A	ENST00000308059.6	+	35	4979	c.4958G>A	c.(4957-4959)cGa>cAa	p.R1653Q	DLEC1_ENST00000452631.2_Missense_Mutation_p.R1656Q|DLEC1_ENST00000346219.3_Missense_Mutation_p.R1653Q			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	1653					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AGCCAGCAGCGAGTCCGGGAG	0.632													25	52					0	0	1	0	0	A	38163210	G	A	38163210	3	1	48	1	0	0	0	0	1	0	0	0	4580	1058	37	1	5096	1	DLEC1	3	38163210	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	341742	38163210	159859220	895	5289										
SCN5A	6331	broad.mit.edu	37	chr3	38595795	38595795	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggagaggatgacaaccacGaagtcgaagatattccagct	11	8	0	3	rs141789366	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:38595795G>A	ENST00000413689.1	-	27	4981	c.4788C>T	c.(4786-4788)ttC>ttT	p.F1596F	SCN5A_ENST00000333535.4_Silent_p.F1596F|SCN5A_ENST00000423572.2_Silent_p.F1595F|SCN5A_ENST00000414099.2_Silent_p.F1578F|SCN5A_ENST00000443581.1_Silent_p.F1595F|SCN5A_ENST00000425664.1_Silent_p.F1578F|SCN5A_ENST00000455624.2_Intron|SCN5A_ENST00000451551.2_Silent_p.F1542F|SCN5A_ENST00000450102.2_Silent_p.F1542F|SCN5A_ENST00000449557.2_Silent_p.F1542F|SCN5A_ENST00000464652.1_5'UTR	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1596					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.F1596F(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGACAACCACGAAGTCGAAGA	0.567													28	44					0	0	1	0	0	A	38595795	G	A	38595795	2	1	48	1	0	0	0	0	0	0	0	1	13975	1049	37	1		1	SCN5A	3	38595795	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	432585	38595795	159426635	896	5290										
SCN11A	11280	broad.mit.edu	37	chr3	38936224	38936224	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgaccaggggaatgatgtCtttgctttgtgcagcacagc	12	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:38936224C>T	ENST00000302328.3	-	15	2833	c.2635G>A	c.(2635-2637)Gac>Aac	p.D879N	SCN11A_ENST00000444237.2_Missense_Mutation_p.D879N|SCN11A_ENST00000450244.1_Missense_Mutation_p.D879N|SCN11A_ENST00000456224.3_Missense_Mutation_p.D879N	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	879					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGAATGATGTCTTTGCTTTGT	0.507													24	48					0	0	1	0	0	T	38936224	C	T	38936224	3	4	48	1	0	0	0	0	1	0	0	0	13966	913	32	3	2788	3	SCN11A	3	38936224	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	340429	38936224	159086206	897	5291										
SCN11A	11280	broad.mit.edu	37	chr3	38968336	38968336	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagccagttccatggatctCgaaggaaagaaaactcatcc	8	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:38968336C>T	ENST00000302328.3	-	4	773	c.575G>A	c.(574-576)cGa>cAa	p.R192Q	SCN11A_ENST00000444237.2_Missense_Mutation_p.R192Q|SCN11A_ENST00000450244.1_Missense_Mutation_p.R192Q|SCN11A_ENST00000456224.3_Missense_Mutation_p.R192Q	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	192					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCATGGATCTCGAAGGAAAGA	0.378													56	78					0	0	1	0	0	T	38968336	C	T	38968336	3	4	48	1	0	0	0	0	1	0	0	0	13966	884	31	1	4892	1	SCN11A	3	38968336	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32112	38968336	159054094	898	5292										
SCN11A	11280	broad.mit.edu	37	chr3	38991631	38991631	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagtcttccagaggctttcCtatgagctcacgaggaatgt	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:38991631C>A	ENST00000302328.3	-	1	421	c.223G>T	c.(223-225)Gga>Tga	p.G75*	SCN11A_ENST00000444237.2_Nonsense_Mutation_p.G75*|SCN11A_ENST00000450244.1_Nonsense_Mutation_p.G75*|SCN11A_ENST00000456224.3_Nonsense_Mutation_p.G75*	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	75					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AGAGGCTTTCCTATGAGCTCA	0.562													44	82					2.37825e-27	3.36934e-27	1	1	0	A	38991631	C	A	38991631	4	1	48	1	0	0	0	0	0	1	0	0	13966	690	24	5	5256	5	SCN11A	3	38991631	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23295	38991631	159030799	899	5293										
WDR48	57599	broad.mit.edu	37	chr3	39116403	39116403	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctaagaaaccctgacattCgggtgctaatttgtgaagaa	9	8	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:39116403C>T	ENST00000302313.5	+	8	887	c.859C>T	c.(859-861)Cgg>Tgg	p.R287W	WDR48_ENST00000396258.3_Missense_Mutation_p.R205W|WDR48_ENST00000544962.1_Missense_Mutation_p.R79W|WDR48_ENST00000418020.1_5'UTR	NM_020839.2	NP_065890.1	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	287					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			breast(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CCCTGACATTCGGGTGCTAAT	0.383													16	37					0	0	1	0	0	T	39116403	C	T	39116403	3	4	48	1	0	0	0	0	1	0	0	0	17360	875	31	1	889	1	WDR48	3	39116403	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	124772	39116403	158906027	900	5294										
TTC21A	199223	broad.mit.edu	37	chr3	39159652	39159652	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacatgaccacagtaagttCtttgaagactcagaaggtga	9	7	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:39159652C>A	ENST00000301819.6	+	7	986	c.809C>A	c.(808-810)tCt>tAt	p.S270Y	TTC21A_ENST00000431162.2_Missense_Mutation_p.S270Y|TTC21A_ENST00000440121.1_Intron	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	270							binding	p.S270Y(2)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		ACAGTAAGTTCTTTGAAGACT	0.458													32	57					3.11337e-16	4.1367e-16	1	1	0	A	39159652	C	A	39159652	3	1	48	1	0	0	0	0	1	0	0	0	16748	913	32	2	835	2	TTC21A	3	39159652	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	43249	39159652	158862778	901	5295										
CCR8	1237	broad.mit.edu	37	chr3	39374588	39374588	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctgggtcccattcaacGtggttcttttcctcacttcc	6	13	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:39374588G>A	ENST00000326306.4	+	2	904	c.766G>A	c.(766-768)Gtg>Atg	p.V256M	CCR8_ENST00000545843.1_Missense_Mutation_p.V173M|CCR8_ENST00000414803.1_3'UTR	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	256					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CCCATTCAACGTGGTTCTTTT	0.463													15	29					0	0	1	0	0	A	39374588	G	A	39374588	3	1	48	1	0	0	0	0	1	0	0	0	2969	1145	40	1	768	1	CCR8	3	39374588	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	214936	39374588	158647842	902	5296										
RPSA	3921	broad.mit.edu	37	chr3	39449160	39449160	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacaatgtccggagcccttGatgtcctgcaaatgaaggag	11	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:39449160G>A	ENST00000301821.6	+	2	125	c.16G>A	c.(16-18)Gat>Aat	p.D6N	RPSA_ENST00000443003.1_Missense_Mutation_p.D6N	NM_001012321.1|NM_002295.4	NP_001012321.1|NP_002286.2	P08865	RSSA_HUMAN	ribosomal protein SA	6					cell adhesion|endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly|rRNA export from nucleus|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleus|plasma membrane	protein binding|receptor activity|ribosome binding|structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)		Cggagcccttgatgtcctgca	0.438													24	23					0	0	1	0	0	A	39449160	G	A	39449160	3	1	48	1	0	0	0	0	1	0	0	0	13714	1290	45	3	18	3	RPSA	3	39449160	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	74572	39449160	158573270	903	5297										
ZNF619	285267	broad.mit.edu	37	chr3	40528772	40528772	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaaaatccacactggagaGaaaccatactcatgtgagga	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:40528772G>T	ENST00000447116.2	+	6	1198	c.891G>T	c.(889-891)gaG>gaT	p.E297D	ZNF619_ENST00000314686.5_Missense_Mutation_p.E241D|ZNF619_ENST00000520737.1_3'UTR|ZNF619_ENST00000429348.2_Missense_Mutation_p.E257D|ZNF619_ENST00000522736.1_Missense_Mutation_p.E248D|ZNF619_ENST00000456778.1_Missense_Mutation_p.E213D|ZNF619_ENST00000432264.2_Missense_Mutation_p.E257D|ZNF619_ENST00000521353.1_Missense_Mutation_p.E297D	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	297					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		ACACTGGAGAGAAACCATACT	0.443													20	43					3.99206e-14	5.17458e-14	1	1	0	T	40528772	G	T	40528772	3	4	48	1	0	0	0	0	1	0	0	0	18099	933	33	2	931	2	ZNF619	3	40528772	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1079612	40528772	157493658	904	5298										
ZNF620	253639	broad.mit.edu	37	chr3	40558152	40558152	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccttgactcagcatcagcGaattcacactggggagaagc	11	11	3	2	rs149375136		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:40558152G>A	ENST00000314529.6	+	5	1216	c.1067G>A	c.(1066-1068)cGa>cAa	p.R356Q	ZNF620_ENST00000418905.1_Missense_Mutation_p.R242Q	NM_175888.3	NP_787084.1	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(1)|urinary_tract(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CAGCATCAGCGAATTCACACT	0.473													28	49					0	0	1	0	0	A	40558152	G	A	40558152	3	1	48	1	0	0	0	0	1	0	0	0	18100	1058	37	1	1081	1	ZNF620	3	40558152	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29380	40558152	157464278	905	5299										
ZNF621	285268	broad.mit.edu	37	chr3	40574146	40574146	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaccttatcaatgtaaggaGtgtggcaaagccttcaccca	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:40574146G>A	ENST00000339296.5	+	5	1337	c.885G>A	c.(883-885)gaG>gaA	p.E295E	ZNF621_ENST00000403205.2_Silent_p.E295E|ZNF621_ENST00000310898.1_Intron|ZNF621_ENST00000431278.1_Silent_p.E184E|ZNF621_ENST00000490457.1_Intron	NM_198484.3	NP_940886.1	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		AATGTAAGGAGTGTGGCAAAG	0.423													20	45					0	0	1	0	0	A	40574146	G	A	40574146	2	1	48	1	0	0	0	0	0	0	0	1	18101	1020	36	3		3	ZNF621	3	40574146	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	15994	40574146	157448284	906	5300										
CCDC13	152206	broad.mit.edu	37	chr3	42799615	42799615	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagatttcaaacttgcatttAcctcttctcaaagctatttt	4	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:42799615A>C	ENST00000310232.6	-	2	305		c.e2+1		CCDC13_ENST00000435327.2_Splice_Site	NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13											endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						ACTTGCATTTACCTCTTCTCA	0.483													21	39					0	0	1	0	0	C	42799615	A	C	42799615	5	2	48	1	0	0	0	0	0	0	1	0	2783	405	14	4	1984	4	CCDC13	3	42799615	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2225469	42799615	155222815	907	5301										
SNRK	54861	broad.mit.edu	37	chr3	43344729	43344729	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcgagggtatgatggaaagAttgctggattatatgatctg	14	3	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:43344729A>C	ENST00000296088.7	+	3	338	c.34A>C	c.(34-36)Att>Ctt	p.I12L	SNRK_ENST00000454177.1_Missense_Mutation_p.I12L|SNRK_ENST00000429705.2_Missense_Mutation_p.I12L|SNRK_ENST00000462810.1_3'UTR|SNRK_ENST00000437827.1_Intron	NM_017719.4	NP_060189.3	Q9NRH2	SNRK_HUMAN	SNF related kinase	12					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(5)|prostate(1)|skin(2)|stomach(1)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		TGATGGAAAGATTGCTGGATT	0.398													9	63					0	0	1	0	0	C	43344729	A	C	43344729	3	2	48	1	0	0	0	0	1	0	0	0	14904	333	12	4	36	4	SNRK	3	43344729	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	545114	43344729	154677701	908	5302										
ZNF445	353274	broad.mit.edu	37	chr3	44489458	44489458	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctatactgattcaattcaaGaaatttcttcttagcatggg	6	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44489458G>T	ENST00000425708.2	-	7	2046	c.1705C>A	c.(1705-1707)Ctt>Att	p.L569I	ZNF445_ENST00000396077.2_Missense_Mutation_p.L569I			P59923	ZN445_HUMAN	zinc finger protein 445	569					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TTCAATTCAAGAAATTTCTTC	0.468													32	65					1.62565e-12	2.05093e-12	1	1	0	T	44489458	G	T	44489458	3	4	48	1	0	0	0	0	1	0	0	0	17974	942	33	2	1394	2	ZNF445	3	44489458	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1144729	44489458	153532972	909	5303										
ZNF445	353274	broad.mit.edu	37	chr3	44489996	44489996	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agactattacttcctgatacTtcagagtcttttcctgtcct	5	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44489996T>G	ENST00000425708.2	-	7	1508	c.1167A>C	c.(1165-1167)gaA>gaC	p.E389D	ZNF445_ENST00000396077.2_Missense_Mutation_p.E389D			P59923	ZN445_HUMAN	zinc finger protein 445	389					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E389D(1)		breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TTCCTGATACTTCAGAGTCTT	0.378													29	53					0	0	1	0	0	G	44489996	T	G	44489996	3	3	48	1	0	0	0	0	1	0	0	0	17974	1606	56	4	1932	4	ZNF445	3	44489996	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	538	44489996	153532434	910	5304										
ZNF197	10168	broad.mit.edu	37	chr3	44684747	44684747	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggagaagccatatgaatgtCgagagtgtgggaaaaccttt	14	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44684747C>T	ENST00000396058.1	+	5	2292	c.2125C>T	c.(2125-2127)Cga>Tga	p.R709*	ZNF197_ENST00000383744.4_Intron|ZNF197_ENST00000344387.4_Nonsense_Mutation_p.R709*|RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	709					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ATATGAATGTCGAGAGTGTGG	0.413													41	54					0	0	1	0	0	T	44684747	C	T	44684747	4	4	48	1	0	0	0	0	0	1	0	0	17816	876	31	1	2143	1	ZNF197	3	44684747	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	194751	44684747	153337683	911	5305										
ZNF197	10168	broad.mit.edu	37	chr3	44685303	44685303	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatcttatggtacatcaaaGaatccatactggagagaaac	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44685303G>T	ENST00000396058.1	+	5	2848	c.2681G>T	c.(2680-2682)aGa>aTa	p.R894I	ZNF197_ENST00000383744.4_Intron|ZNF197_ENST00000344387.4_Missense_Mutation_p.R894I|RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	894					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		GTACATCAAAGAATCCATACT	0.358													36	62					4.62619e-21	6.37263e-21	1	1	0	T	44685303	G	T	44685303	3	4	48	1	0	0	0	0	1	0	0	0	17816	942	33	2	2699	2	ZNF197	3	44685303	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	556	44685303	153337127	912	5306										
TGM4	7047	broad.mit.edu	37	chr3	44948523	44948523	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgacaccagattcgtcttCtcagaagtgaatggtgacag	10	8	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44948523C>A	ENST00000296125.4	+	10	1226	c.1158C>A	c.(1156-1158)ttC>ttA	p.F386L		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	386					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GATTCGTCTTCTCAGAAGTGA	0.507													47	69					3.4345e-17	4.60033e-17	1	1	0	A	44948523	C	A	44948523	3	1	48	1	0	0	0	0	1	0	0	0	15891	912	32	2	1196	2	TGM4	3	44948523	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	263220	44948523	153073907	913	5307										
TGM4	7047	broad.mit.edu	37	chr3	44955154	44955154	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacccaagaaatttatcgtCaagttaagttccaaacaagt	7	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44955154C>A	ENST00000296125.4	+	14	2060	c.1992C>A	c.(1990-1992)gtC>gtA	p.V664V		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	664					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	AATTTATCGTCAAGTTAAGTT	0.413											OREG0015520	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	63					0.0381472	0.0387537	1	1	0	A	44955154	C	A	44955154	2	1	48	1	0	0	0	0	0	0	0	1	15891	813	29	2		2	TGM4	3	44955154	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6631	44955154	153067276	914	5308										
ZDHHC3	51304	broad.mit.edu	37	chr3	44986746	44986746	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttcaactgtaaactctcGatgaattctttagtggcatt	8	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:44986746G>A	ENST00000296127.3	-	3	618	c.345C>T	c.(343-345)atC>atT	p.I115I	ZDHHC3_ENST00000342790.4_Silent_p.I149I|ZDHHC3_ENST00000424952.2_Silent_p.I115I	NM_016598.2	NP_057682.1	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3	115						Golgi membrane|integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		GTAAACTCTCGATGAATTCTT	0.527													53	79					0	0	1	0	0	A	44986746	G	A	44986746	2	1	48	1	0	0	0	0	0	0	0	1	17673	1048	37	1		1	ZDHHC3	3	44986746	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	31592	44986746	153035684	915	5309										
LARS2	23395	broad.mit.edu	37	chr3	45537860	45537860	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacactgaccctcataatccAcacaggtaaaacgtccctgc	5	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:45537860A>G	ENST00000415258.1	+	13	1758	c.1617A>G	c.(1615-1617)ccA>ccG	p.P539P	LARS2_ENST00000265537.3_Silent_p.P539P|LARS2_ENST00000414984.1_Silent_p.P496P|LARS2-AS1_ENST00000442534.2_RNA			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	539					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	CTCATAATCCACACAGGTAAA	0.448													49	115					0	0	1	0	0	G	45537860	A	G	45537860	2	3	48	1	0	0	0	0	0	0	0	1	8673	146	6	4		4	LARS2	3	45537860	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	551114	45537860	152484570	916	5310										
SACM1L	22908	broad.mit.edu	37	chr3	45763501	45763501	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctatttaggaattgattCggaaggccatgcagctaact	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:45763501C>T	ENST00000389061.5	+	9	893	c.689C>T	c.(688-690)tCg>tTg	p.S230L	SACM1L_ENST00000418611.1_Missense_Mutation_p.S127L|SACM1L_ENST00000541314.1_Missense_Mutation_p.S169L	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	230	SAC.					Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GGAATTGATTCGGAAGGCCAT	0.353													14	18					0	0	1	0	0	T	45763501	C	T	45763501	3	4	48	1	0	0	0	0	1	0	0	0	13854	893	31	1	723	1	SACM1L	3	45763501	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	225641	45763501	152258929	917	5311										
SLC6A20	54716	broad.mit.edu	37	chr3	45817310	45817310	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacaccaccagccaggccagGaggaggcacagcgccggctc	13	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:45817310G>A	ENST00000358525.4	-	4	640	c.525C>T	c.(523-525)ctC>ctT	p.L175L	SLC6A20_ENST00000353278.4_Silent_p.L175L|SLC6A20_ENST00000456124.2_Silent_p.L175L	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	175					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		GCCAGGCCAGGAGGAGGCACA	0.637													45	47					0	0	1	0	0	A	45817310	G	A	45817310	2	1	48	1	0	0	0	0	0	0	0	1	14738	1161	41	3		3	SLC6A20	3	45817310	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53809	45817310	152205120	918	5312										
CCR3	1232	broad.mit.edu	37	chr3	46307386	46307386	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcatttttgtcatcatggCggtgtttttcattttctgga	9	7	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:46307386C>T	ENST00000357422.2	+	4	1280	c.737C>T	c.(736-738)gCg>gTg	p.A246V	CCR3_ENST00000395940.2_Missense_Mutation_p.A246V|CCR3_ENST00000395942.2_Missense_Mutation_p.A246V|CCR3_ENST00000545097.1_Missense_Mutation_p.A267V|CCR3_ENST00000541018.1_Missense_Mutation_p.A246V			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	246					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		GTCATCATGGCGGTGTTTTTC	0.453													18	31					0	0	1	0	0	T	46307386	C	T	46307386	3	4	48	1	0	0	0	0	1	0	0	0	2964	768	27	1	806	1	CCR3	3	46307386	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	490076	46307386	151715044	919	5313										
CCR5	1234	broad.mit.edu	37	chr3	46415317	46415317	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaagttcagaaactacctCttagtcttcttccaaaagca	6	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:46415317C>A	ENST00000343801.4	+	3	1281	c.924C>A	c.(922-924)ctC>ctA	p.L308L	CCR5_ENST00000445772.1_Silent_p.L308L|RP11-24F11.2_ENST00000451485.1_RNA|CCR5_ENST00000292303.4_Silent_p.L308L	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	308					cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GAAACTACCTCTTAGTCTTCT	0.493													51	83					5.85753e-14	7.57693e-14	1	1	0	A	46415317	C	A	46415317	2	1	48	1	0	0	0	0	0	0	0	1	2966	900	32	2		2	CCR5	3	46415317	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	107931	46415317	151607113	920	5314										
LTF	4057	broad.mit.edu	37	chr3	46497452	46497452	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaccacagccacggcataAtagtgagttcgtggctctgc	10	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:46497452A>C	ENST00000231751.4	-	4	628	c.333T>G	c.(331-333)taT>taG	p.Y111*	LTF_ENST00000426532.2_Nonsense_Mutation_p.Y67*|LTF_ENST00000417439.1_Nonsense_Mutation_p.Y111*	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	111	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CCACGGCATAATAGTGAGTTC	0.537													9	25					0	0	1	0	0	C	46497452	A	C	46497452	4	2	48	1	0	0	0	0	0	1	0	0	9123	108	4	4	1855	4	LTF	3	46497452	Nonsense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	82135	46497452	151524978	921	5315										
PRSS42	339906	broad.mit.edu	37	chr3	46874577	46874577	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagaagggcaaggtcatttCgaatggttgtaactgttgag	15	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:46874577C>T	ENST00000447340.1	-	2	232	c.179G>A	c.(178-180)cGa>cAa	p.R60Q	PRSS42_ENST00000429665.1_Missense_Mutation_p.R164Q			Q7Z5A4	PRS42_HUMAN	protease, serine, 42	164					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	8						AAGGTCATTTCGAATGGTTGT	0.458													26	39					0	0	1	0	0	T	46874577	C	T	46874577	3	4	48	1	0	0	0	0	1	0	0	0	12676	884	31	1	401	1	PRSS42	3	46874577	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	377125	46874577	151147853	922	5316										
SETD2	29072	broad.mit.edu	37	chr3	47103827	47103827	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccaacagcatcccttcctCgttcagttgctaagggaaaa	8	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:47103827C>T	ENST00000409792.3	-	14	6161	c.6119G>A	c.(6118-6120)cGa>cAa	p.R2040Q	SETD2_ENST00000492397.1_5'UTR	NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2040					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATCCCTTCCTCGTTCAGTTGC	0.393			"N, F, S, Mis"		clear cell renal carcinoma								58	116					0	0	1	0	0	T	47103827	C	T	47103827	3	4	48	1	0	0	0	0	1	0	0	0	14184	884	31	1	1607	1	SETD2	3	47103827	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	229250	47103827	150918603	923	5317										
SCAP	22937	broad.mit.edu	37	chr3	47456433	47456433	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggtgacaggccactgtgtCgctgctgctgtacactggag	14	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:47456433C>T	ENST00000265565.5	-	20	3602	c.3190G>A	c.(3190-3192)Gac>Aac	p.D1064N	SCAP_ENST00000545718.1_Missense_Mutation_p.D671N|SCAP_ENST00000441517.2_Missense_Mutation_p.D808N	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	1064	Interaction with SREBF2 (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GCCACTGTGTCGCTGCTGCTG	0.597													4	68					0	0	1	0	0	T	47456433	C	T	47456433	3	4	48	1	0	0	0	0	1	0	0	0	13929	884	31	1	665	1	SCAP	3	47456433	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	352606	47456433	150565997	924	5318										
CSPG5	10675	broad.mit.edu	37	chr3	47618877	47618877	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctcaccatccagtccttcGaagtagtcgatgtcaatgat	7	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:47618877G>A	ENST00000383738.2	-	2	2737	c.639C>T	c.(637-639)ttC>ttT	p.F213F	CSPG5_ENST00000264723.4_Silent_p.F213F|CSPG5_ENST00000456150.1_Silent_p.F75F	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	213					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCAGTCCTTCGAAGTAGTCGA	0.592													14	39					0	0	1	0	0	A	47618877	G	A	47618877	2	1	48	1	0	0	0	0	0	0	0	1	3986	1049	37	1		1	CSPG5	3	47618877	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	162444	47618877	150403553	925	5319										
ZNF589	51385	broad.mit.edu	37	chr3	48310236	48310236	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagctcattaagcaccagaGaattcacacgggggataagc	11	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:48310236G>T	ENST00000354698.3	+	4	1127	c.1055G>T	c.(1054-1056)aGa>aTa	p.R352I	ZNF589_ENST00000412564.1_Intron|ZNF589_ENST00000440261.2_Intron|ZNF589_ENST00000427617.2_Intron	NM_016089.2	NP_057173.2	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	352					regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AAGCACCAGAGAATTCACACG	0.478													25	81					3.6726e-16	4.87283e-16	1	1	0	T	48310236	G	T	48310236	3	4	48	1	0	0	0	0	1	0	0	0	18077	942	33	2	1069	2	ZNF589	3	48310236	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	691359	48310236	149712194	926	5320										
ATRIP	84126	broad.mit.edu	37	chr3	48502155	48502155	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacccagtgccttaaggttTtggtgaaattagccgaaaac	10	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:48502155T>G	ENST00000412052.1	+	8	1885	c.1423T>G	c.(1423-1425)Ttg>Gtg	p.L475V	ATRIP_ENST00000357105.6_Missense_Mutation_p.L441V|ATRIP_ENST00000346691.4_Missense_Mutation_p.L568V|ATRIP_ENST00000320211.3_Missense_Mutation_p.L568V	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	568					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCTTAAGGTTTTGGTGAAATT	0.473								Other conserved DNA damage response genes					22	52					0	0	1	0	0	G	48502155	T	G	48502155	3	3	48	1	0	0	0	0	1	0	0	0	1203	1838	64	4	1732	4	ATRIP	3	48502155	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	191919	48502155	149520275	927	5321										
COL7A1	1294	broad.mit.edu	37	chr3	48630293	48630293	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtcacagggccactggccGctgtccactgtactctcaag	10	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:48630293G>A	ENST00000328333.8	-	6	868	c.761C>T	c.(760-762)gCg>gTg	p.A254V	COL7A1_ENST00000454817.1_Missense_Mutation_p.A254V	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	254	Fibronectin type-III 1.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCACTGGCCGCTGTCCACTG	0.617													14	22					0	0	1	0	0	A	48630293	G	A	48630293	3	1	48	1	0	0	0	0	1	0	0	0	3727	1087	38	1	8525	1	COL7A1	3	48630293	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	128138	48630293	149392137	928	5322										
COL7A1	1294	broad.mit.edu	37	chr3	48630635	48630635	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtcattgacgaagaagaaGaagtcactggtgggctgtga	14	5	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:48630635G>T	ENST00000328333.8	-	5	689	c.582C>A	c.(580-582)ttC>ttA	p.F194L	COL7A1_ENST00000454817.1_Missense_Mutation_p.F194L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	194	Nonhelical region (NC1).|VWFA 1.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGAAGAAGAAGAAGTCACTGG	0.567													9	66					0.000442599	0.00046913	1	1	0	T	48630635	G	T	48630635	3	4	48	1	0	0	0	0	1	0	0	0	3727	933	33	2	8708	2	COL7A1	3	48630635	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	342	48630635	149391795	929	5323										
CELSR3	1951	broad.mit.edu	37	chr3	48699046	48699046	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacgcgtagcaccgcggtgCctgctgcctcattctccggc	11	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:48699046C>T	ENST00000544264.1	-	1	1302	c.1022G>A	c.(1021-1023)gGc>gAc	p.G341D	CELSR3_ENST00000164024.4_Missense_Mutation_p.G341D			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	341	Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CACCGCGGTGCCTGCTGCCTC	0.682													40	75					0	0	1	0	0	T	48699046	C	T	48699046	3	4	48	1	0	0	0	0	1	0	0	0	3245	739	26	3	9056	3	CELSR3	3	48699046	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	68411	48699046	149323384	930	5324										
LAMB2	3913	broad.mit.edu	37	chr3	49160170	49160170	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcacactctggataagttCttgaagttcctggttggcct	9	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:49160170C>A	ENST00000418109.1	-	28	4704	c.4540G>T	c.(4540-4542)Gaa>Taa	p.E1514*	LAMB2_ENST00000305544.4_Nonsense_Mutation_p.E1514*	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1514	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGGATAAGTTCTTGAAGTTCC	0.597													9	122					0.00621372	0.0064192	1	1	0	A	49160170	C	A	49160170	4	1	48	1	0	0	0	0	0	1	0	0	8649	922	32	2	880	2	LAMB2	3	49160170	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	461124	49160170	148862260	931	5325										
DAG1	1605	broad.mit.edu	37	chr3	49570157	49570157	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccgcccacagaagtgcctgAcagggaccctgagaagagca	13	13	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:49570157A>C	ENST00000545947.1	+	6	2935	c.2213A>C	c.(2212-2214)gAc>gCc	p.D738A	DAG1_ENST00000308775.2_Missense_Mutation_p.D738A|DAG1_ENST00000515359.2_Missense_Mutation_p.D738A|DAG1_ENST00000538711.1_Missense_Mutation_p.D738A|DAG1_ENST00000539901.1_Missense_Mutation_p.D738A|DAG1_ENST00000541308.1_Missense_Mutation_p.D738A	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	738					cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAAGTGCCTGACAGGGACCCT	0.592													25	54					0	0	1	0	0	C	49570157	A	C	49570157	3	2	48	1	0	0	0	0	1	0	0	0	4249	275	10	4	2219	4	DAG1	3	49570157	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	409987	49570157	148452273	932	5326										
MON1A	84315	broad.mit.edu	37	chr3	49946481	49946481	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgtgagaatgaagaggcggTcttcctctttgcggatccag	14	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:49946481T>C	ENST00000417270.1	-	7	2351	c.1658A>G	c.(1657-1659)gAc>gGc	p.D553G	MON1A_ENST00000455683.2_Missense_Mutation_p.D480G|CTD-2330K9.3_ENST00000419183.1_Intron|MON1A_ENST00000296473.3_Missense_Mutation_p.D642G			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	545							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GAAGAGGCGGTCTTCCTCTTT	0.582													16	21					0	0	1	0	0	C	49946481	T	C	49946481	3	2	48	1	0	0	0	0	1	0	0	0	9746	1667	58	4	37	4	MON1A	3	49946481	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	376324	49946481	148075949	933	5327										
SLC38A3	10991	broad.mit.edu	37	chr3	50255384	50255384	+	RNA	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccatcatggccttcgccttCgtctgccaccccgaggtgct	9	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:50255384C>T	ENST00000420502.1	+	0	1044							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CCTTCGCCTTCGTCTGCCACC	0.617													12	37					0	0	1	0	0	T	50255384	C	T	50255384	1	4	48	0	1	0	0	0	0	0	0	0	14659	883	31	1		1	SLC38A3	3	50255384	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	308903	50255384	147767046	934	5328										
ZMYND10	51364	broad.mit.edu	37	chr3	50382591	50382591	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagctcctgaatgggctcGccctggctgactgtggcatc	13	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:50382591G>A	ENST00000231749.3	-	2	1437	c.165C>T	c.(163-165)ggC>ggT	p.G55G	ZMYND10_ENST00000360165.3_Silent_p.G55G|ZMYND10-AS1_ENST00000440013.1_RNA	NM_015896.2	NP_056980.2	O75800	ZMY10_HUMAN	zinc finger, MYND-type containing 10	55						cytoplasm	protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|urinary_tract(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GAATGGGCTCGCCCTGGCTGA	0.602										TSP Lung(30;0.18)			7	18					0	0	1	0	0	A	50382591	G	A	50382591	2	1	48	1	0	0	0	0	0	0	0	1	17762	1074	38	1		1	ZMYND10	3	50382591	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	127207	50382591	147639839	935	5329										
DOCK3	1795	broad.mit.edu	37	chr3	51413217	51413217	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccctgttccagcaagtggtCggagcctgcaaaccctgcag	12	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:51413217C>T	ENST00000266037.9	+	51	5474	c.5451C>T	c.(5449-5451)gtC>gtT	p.V1817V		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1817						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.V1817V(1)		breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGCAAGTGGTCGGAGCCTGCA	0.517													28	62					0	0	1	0	0	T	51413217	C	T	51413217	2	4	48	1	0	0	0	0	0	0	0	1	4715	871	31	1		1	DOCK3	3	51413217	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1030626	51413217	146609213	936	5330										
VPRBP	9730	broad.mit.edu	37	chr3	51500889	51500889	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatacactctggatcagctCgacctaccaagagaagaggg	11	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:51500889C>T	ENST00000335891.5	-	3	200	c.191G>A	c.(190-192)cGa>cAa	p.R64Q				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	64					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TGGATCAGCTCGACCTACCAA	0.453													20	21					0	0	1	0	0	T	51500889	C	T	51500889	3	4	48	1	0	0	0	0	1	0	0	0	17244	884	31	1	4253	1	VPRBP	3	51500889	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	87672	51500889	146521541	937	5331										
VPRBP	9730	broad.mit.edu	37	chr3	51517794	51517794	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttttcccactgctccagCagggtagtgagctcagcttt	9	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:51517794C>T	ENST00000335891.5	-	1	60	c.51G>A	c.(49-51)ctG>ctA	p.L17L				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	17					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		ACTGCTCCAGCAGGGTAGTGA	0.393													34	59					0	0	1	0	0	T	51517794	C	T	51517794	2	4	48	1	0	0	0	0	0	0	0	1	17244	697	25	3		3	VPRBP	3	51517794	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16905	51517794	146504636	938	5332										
GRM2	2912	broad.mit.edu	37	chr3	51749334	51749334	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaagagtgtgcagccgggCgaagtctgctgctggctctg	17	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:51749334C>T	ENST00000395052.3	+	4	1779	c.1545C>T	c.(1543-1545)ggC>ggT	p.G515G	GRM2_ENST00000475478.1_3'UTR|GRM2_ENST00000442933.2_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	515					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TGCAGCCGGGCGAAGTCTGCT	0.632													15	20					0	0	1	0	0	T	51749334	C	T	51749334	2	4	48	1	0	0	0	0	0	0	0	1	6837	755	27	1		1	GRM2	3	51749334	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	231540	51749334	146273096	939	5333										
IQCF1	132141	broad.mit.edu	37	chr3	51928930	51928930	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctttattgagaagggaatAcactctgtcacaatgcaagg	9	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:51928930A>G	ENST00000310914.5	-	4	656	c.594T>C	c.(592-594)tgT>tgC	p.C198C		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	198										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGAAGGGAATACACTCTGTCA	0.498													33	55					0	0	1	0	0	G	51928930	A	G	51928930	2	3	48	1	0	0	0	0	0	0	0	1	7850	389	14	4		4	IQCF1	3	51928930	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	179596	51928930	146093500	940	5334										
PPM1M	132160	broad.mit.edu	37	chr3	52283790	52283790	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacgtctctgtgttcgtgaTtcccttgcacagtcagggcc	11	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:52283790T>G	ENST00000323588.4	+	10	1222	c.857T>G	c.(856-858)aTt>aGt	p.I286S	PPM1M_ENST00000296487.4_3'UTR|PPM1M_ENST00000457351.2_Missense_Mutation_p.I447S|PPM1M_ENST00000409502.3_Missense_Mutation_p.I235S			Q96MI6	PPM1M_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1M	0					protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding			prostate(1)|urinary_tract(1)	2				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		GTGTTCGTGATTCCCTTGCAC	0.552													7	39					0	0	1	0	0	G	52283790	T	G	52283790	3	3	48	1	0	0	0	0	1	0	0	0	12393	1493	52	4	887	4	PPM1M	3	52283790	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	354860	52283790	145738640	941	5335										
SEMA3G	56920	broad.mit.edu	37	chr3	52469702	52469702	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgcctagctccagccctgCccagctcttgcccctggcct	8	20	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:52469702C>T	ENST00000231721.2	-	16	2265	c.2266G>A	c.(2266-2268)Gca>Aca	p.A756T		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	756					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		TCCAGCCCTGCCCAGCTCTTG	0.672													9	118					0	0	1	0	0	T	52469702	C	T	52469702	3	4	48	1	0	0	0	0	1	0	0	0	14083	739	26	3	86	3	SEMA3G	3	52469702	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	185912	52469702	145552728	942	5336										
STAB1	23166	broad.mit.edu	37	chr3	52553522	52553522	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgagagcctttcctcagaGaaatgtcaccgccgccgccc	9	15	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:52553522G>T	ENST00000321725.6	+	50	5253	c.5175_splice	c.e50-1	p.R1726_splice		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1726	FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TTTCCTCAGAGAAATGTCACC	0.602													8	88					0.000274275	0.000292037	1	1	0	T	52553522	G	T	52553522	5	4	48	1	0	0	0	0	0	0	1	0	15292	956	33	2	5375	2	STAB1	3	52553522	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	83820	52553522	145468908	943	5337										
PBRM1	55193	broad.mit.edu	37	chr3	52610695	52610695	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaatatgcagctccatctcGaacccatactttttcaattc	3	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:52610695G>A	ENST00000356770.4	-	21	3459	c.3457C>T	c.(3457-3459)Cga>Tga	p.R1153*	SMIM4_ENST00000476842.1_Intron|PBRM1_ENST00000409767.1_Nonsense_Mutation_p.R1200*|PBRM1_ENST00000410007.1_Nonsense_Mutation_p.R1160*|PBRM1_ENST00000409114.3_Nonsense_Mutation_p.R1200*|PBRM1_ENST00000296302.7_Nonsense_Mutation_p.R1185*|PBRM1_ENST00000394830.3_Nonsense_Mutation_p.R1160*|PBRM1_ENST00000409057.1_Nonsense_Mutation_p.R1185*|PBRM1_ENST00000337303.4_Nonsense_Mutation_p.R1185*			Q86U86	PB1_HUMAN	polybromo 1	1185					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.R1185*(3)|p.R1153*(1)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GCTCCATCTCGAACCCATACT	0.338			"Mis, N, F, S, D, O"		"clear cell renal carcinoma, breast"								9	25					0	0	1	0	0	A	52610695	G	A	52610695	4	1	48	1	0	0	0	0	0	1	0	0	11537	1066	37	1	1383	1	PBRM1	3	52610695	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	57173	52610695	145411735	944	5338										
PBRM1	55193	broad.mit.edu	37	chr3	52643768	52643768	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttggccatcatgtgacttcGaattttttccatgtccatgg	9	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:52643768G>A	ENST00000356770.4	-	15	2034	c.2032C>T	c.(2032-2034)Cga>Tga	p.R678*	PBRM1_ENST00000409767.1_Nonsense_Mutation_p.R725*|PBRM1_ENST00000410007.1_Nonsense_Mutation_p.R710*|PBRM1_ENST00000409114.3_Nonsense_Mutation_p.R725*|PBRM1_ENST00000296302.7_Nonsense_Mutation_p.R710*|PBRM1_ENST00000394830.3_Nonsense_Mutation_p.R710*|PBRM1_ENST00000409057.1_Nonsense_Mutation_p.R710*|PBRM1_ENST00000337303.4_Nonsense_Mutation_p.R710*			Q86U86	PB1_HUMAN	polybromo 1	710	Bromo 5.		R -> C.		chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.R710*(2)|p.R678*(1)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATGTGACTTCGAATTTTTTCC	0.438			"Mis, N, F, S, D, O"		"clear cell renal carcinoma, breast"								24	70					0	0	1	0	0	A	52643768	G	A	52643768	4	1	48	1	0	0	0	0	0	1	0	0	11537	1066	37	1	2832	1	PBRM1	3	52643768	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	33073	52643768	145378662	945	5339										
CACNA1D	776	broad.mit.edu	37	chr3	53764549	53764549	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaacactgctcagaaagaaGaagcggaagaaaaggagagg	14	5	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:53764549G>T	ENST00000288139.3	+	17	2480	c.2362G>T	c.(2362-2364)Gaa>Taa	p.E788*	CACNA1D_ENST00000422281.2_Nonsense_Mutation_p.E768*|CACNA1D_ENST00000350061.5_Nonsense_Mutation_p.E768*	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	768					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCAGAAAGAAGAAGCGGAAGA	0.453													15	39					1.05317e-09	1.27574e-09	1	1	0	T	53764549	G	T	53764549	4	4	48	1	0	0	0	0	0	1	0	0	2559	943	33	2	2536	2	CACNA1D	3	53764549	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1120781	53764549	144257881	946	5340										
CACNA1D	776	broad.mit.edu	37	chr3	53783418	53783418	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctttcttcatgatgaacatCtttgtgggctttgtcatcgt	9	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:53783418C>A	ENST00000288139.3	+	28	3616	c.3498C>A	c.(3496-3498)atC>atA	p.I1166I	CACNA1D_ENST00000540742.1_Silent_p.I53I|CACNA1D_ENST00000422281.2_Silent_p.I1146I|CACNA1D_ENST00000350061.5_Silent_p.I1146I	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1146					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TGATGAACATCTTTGTGGGCT	0.413													12	65					1.08611e-07	1.25818e-07	1	1	0	A	53783418	C	A	53783418	2	1	48	1	0	0	0	0	0	0	0	1	2559	903	32	2		2	CACNA1D	3	53783418	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18869	53783418	144239012	947	5341										
ACTR8	93973	broad.mit.edu	37	chr3	53904164	53904164	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtacatcttctttttggtgtCgtcagatgctgaaaagacag	10	7	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:53904164C>T	ENST00000335754.3	-	12	1676	c.1576G>A	c.(1576-1578)Gac>Aac	p.D526N	ACTR8_ENST00000482349.1_Missense_Mutation_p.D415N|ACTR8_ENST00000488802.1_5'UTR|ACTR8_ENST00000231909.7_Missense_Mutation_p.D231N	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	526					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		TTTTTGGTGTCGTCAGATGCT	0.428													20	47					0	0	1	0	0	T	53904164	C	T	53904164	3	4	48	1	0	0	0	0	1	0	0	0	216	884	31	1	306	1	ACTR8	3	53904164	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	120746	53904164	144118266	948	5342										
CACNA2D3	55799	broad.mit.edu	37	chr3	54604114	54604114	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacacttggggatgatgacTtcttcaacataattgctgtg	9	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:54604114T>G	ENST00000474759.1	+	8	919	c.871T>G	c.(871-873)Ttc>Gtc	p.F291V	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.F197V|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.F291V|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.F291V	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	291	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GGATGATGACTTCTTCAACAT	0.443													10	101					0	0	1	0	0	G	54604114	T	G	54604114	3	3	48	1	0	0	0	0	1	0	0	0	2568	1609	56	4	901	4	CACNA2D3	3	54604114	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	699950	54604114	143418316	949	5343										
CACNA2D3	55799	broad.mit.edu	37	chr3	54676264	54676264	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaatacaattggccagatcGaaaggtaagttgatgctgat	10	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:54676264G>A	ENST00000474759.1	+	11	1211	c.1163G>A	c.(1162-1164)cGa>cAa	p.R388Q	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.R294Q|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.R388Q|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.R388Q	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	388	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGGCCAGATCGAAAGGTAAGT	0.463													4	8					0	0	1	0	0	A	54676264	G	A	54676264	3	1	48	1	0	0	0	0	1	0	0	0	2568	1058	37	1	1205	1	CACNA2D3	3	54676264	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	72150	54676264	143346166	950	5344										
ERC2	26059	broad.mit.edu	37	chr3	56468777	56468777	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcctccatatacagctcgatTtgtagcccttcccagagtca	7	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:56468777T>G	ENST00000288221.6	-	2	514	c.259A>C	c.(259-261)Aat>Cat	p.N87H		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	87						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ACAGCTCGATTTGTAGCCCTT	0.502													50	107					0	0	1	0	0	G	56468777	T	G	56468777	3	3	48	1	0	0	0	0	1	0	0	0	5239	1841	64	4	2668	4	ERC2	3	56468777	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1792513	56468777	141553653	951	5345										
ERC2	26059	broad.mit.edu	37	chr3	56468995	56468995	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacgaggggatctggaagggCtaccttccagattggtgatt	14	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:56468995C>T	ENST00000288221.6	-	2	296	c.41G>A	c.(40-42)aGc>aAc	p.S14N		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	14						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCTGGAAGGGCTACCTTCCAG	0.463													7	33					0	0	1	0	0	T	56468995	C	T	56468995	3	4	48	1	0	0	0	0	1	0	0	0	5239	797	28	3	2886	3	ERC2	3	56468995	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	218	56468995	141553435	952	5346										
FAM3D	131177	broad.mit.edu	37	chr3	58639451	58639451	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctgaagctcatgtagcttCgaataaacatccatgtcgtg	9	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:58639451C>T	ENST00000358781.2	-	3	381	c.71G>A	c.(70-72)cGa>cAa	p.R24Q		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	24					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CATGTAGCTTCGAATAAACAT	0.587													36	84					0	0	1	0	0	T	58639451	C	T	58639451	3	4	48	1	0	0	0	0	1	0	0	0	5594	884	31	1	635	1	FAM3D	3	58639451	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2170456	58639451	139382979	953	5347										
CADPS	8618	broad.mit.edu	37	chr3	62423848	62423848	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatcctgagaatggcggacGaaagtcacgtaggcgtcggc	14	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:62423848G>A	ENST00000383710.4	-	28	4057	c.3708C>T	c.(3706-3708)ttC>ttT	p.F1236F	CADPS_ENST00000283269.9_Silent_p.F1197F|CADPS_ENST00000357948.3_Silent_p.F1157F	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1236	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		AATGGCGGACGAAAGTCACGT	0.448													25	40					0	0	1	0	0	A	62423848	G	A	62423848	2	1	48	1	0	0	0	0	0	0	0	1	2588	1049	37	1		1	CADPS	3	62423848	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3784397	62423848	135598582	954	5348										
CADPS	8618	broad.mit.edu	37	chr3	62477118	62477118	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagtggggcaaacaggtcTtgcaggtgtttgtgaaattt	13	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:62477118T>G	ENST00000383710.4	-	21	3271	c.2922A>C	c.(2920-2922)caA>caC	p.Q974H	CADPS_ENST00000283269.9_Missense_Mutation_p.Q984H|CADPS_ENST00000357948.3_Missense_Mutation_p.Q944H	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	974	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CAAACAGGTCTTGCAGGTGTT	0.428													14	83					0	0	1	0	0	G	62477118	T	G	62477118	3	3	48	1	0	0	0	0	1	0	0	0	2588	1606	56	4	1179	4	CADPS	3	62477118	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	53270	62477118	135545312	955	5349										
CADPS	8618	broad.mit.edu	37	chr3	62535683	62535683	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtgactgccccgtggcccGatacatggcctggacccaca	12	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:62535683G>A	ENST00000383710.4	-	11	2210	c.1861C>T	c.(1861-1863)Cgg>Tgg	p.R621W	CADPS_ENST00000283269.9_Missense_Mutation_p.R621W|CADPS_ENST00000357948.3_Missense_Mutation_p.R621W	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	621	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CCCGTGGCCCGATACATGGCC	0.577													40	76					0	0	1	0	0	A	62535683	G	A	62535683	3	1	48	1	0	0	0	0	1	0	0	0	2588	1057	37	1	2353	1	CADPS	3	62535683	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58565	62535683	135486747	956	5350										
PRICKLE2	166336	broad.mit.edu	37	chr3	64084736	64084736	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccaatcatattaagaaatGatacagtttttgctcttctg	5	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:64084736G>T	ENST00000295902.6	-	8	3111	c.2526C>A	c.(2524-2526)atC>atA	p.I842I	RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2_ENST00000564377.1_Silent_p.I898I	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	842						cytoplasm|nuclear membrane	zinc ion binding	p.I842I(1)		breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		ATTAAGAAATGATACAGTTTT	0.433													18	59					0.000958276	0.00100963	1	1	0	T	64084736	G	T	64084736	2	4	48	1	0	0	0	0	0	0	0	1	12538	1280	45	2		2	PRICKLE2	3	64084736	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1549053	64084736	133937694	957	5351										
PRICKLE2	166336	broad.mit.edu	37	chr3	64085004	64085004	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattctgcaaagccaggtccGacacagtcctagggcactgg	11	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:64085004G>A	ENST00000295902.6	-	8	2843	c.2258C>T	c.(2257-2259)tCg>tTg	p.S753L	RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2-AS1_ENST00000476308.1_RNA|PRICKLE2_ENST00000564377.1_Missense_Mutation_p.S809L	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	753						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		AGCCAGGTCCGACACAGTCCT	0.592													26	24					0	0	1	0	0	A	64085004	G	A	64085004	3	1	48	1	0	0	0	0	1	0	0	0	12538	1059	37	1	280	1	PRICKLE2	3	64085004	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	268	64085004	133937426	958	5352										
LRIG1	26018	broad.mit.edu	37	chr3	66434631	66434631	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgacctgtggcagcacattCgaggcgggccatggtggtgg	18	9	0	1	rs140303911		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:66434631C>T	ENST00000383703.3	-	15	2530	c.1927G>A	c.(1927-1929)Gaa>Aaa	p.E643K	SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000496559.2_5'UTR|LRIG1_ENST00000273261.3_Missense_Mutation_p.E619K			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	619	Ig-like C2-type 2.					integral to membrane		p.E619K(1)		NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCAGCACATTCGAGGCGGGCC	0.582													48	100					0	0	1	0	0	T	66434631	C	T	66434631	3	4	48	1	0	0	0	0	1	0	0	0	8988	893	31	1	1450	1	LRIG1	3	66434631	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2349627	66434631	131587799	959	5353										
FAM19A4	151647	broad.mit.edu	37	chr3	68929922	68929922	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttgaggcggacatcagcTtacagcacaccattaacacg	10	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:68929922T>G	ENST00000295569.7	-	3	581	c.89A>C	c.(88-90)aAg>aCg	p.K30T		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	30						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		GGACATCAGCTTACAGCACAC	0.507													25	58					0	0	1	0	0	G	68929922	T	G	68929922	3	3	48	1	0	0	0	0	1	0	0	0	5565	1609	56	4	349	4	FAM19A4	3	68929922	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2495291	68929922	129092508	960	5354										
LMOD3	56203	broad.mit.edu	37	chr3	69171469	69171469	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagcagacaagttggccaaGatttcatcttcattaatctc	6	10	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:69171469G>T	ENST00000420581.2	-	1	248	c.69C>A	c.(67-69)atC>atA	p.I23I	LMOD3_ENST00000489031.1_Silent_p.I23I|LMOD3_ENST00000475434.1_Silent_p.I23I	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	23						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		AGTTGGCCAAGATTTCATCTT	0.403													3	11					0.004672	0.00483628	1	1	0	T	69171469	G	T	69171469	2	4	48	1	0	0	0	0	0	0	0	1	8898	932	33	2		2	LMOD3	3	69171469	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	241547	69171469	128850961	961	5355										
FOXP1	27086	broad.mit.edu	37	chr3	71008510	71008510	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccttcagcttcctctggaTcgaggggctcttctttgacg	11	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:71008510T>C	ENST00000318789.4	-	21	2447	c.1922A>G	c.(1921-1923)gAt>gGt	p.D641G	FOXP1_ENST00000493089.1_Missense_Mutation_p.D640G|FOXP1_ENST00000475937.1_Missense_Mutation_p.D641G|FOXP1_ENST00000498215.1_Missense_Mutation_p.D641G|FOXP1_ENST00000491238.1_Missense_Mutation_p.D643G|FOXP1_ENST00000484350.1_Missense_Mutation_p.D565G|FOXP1_ENST00000468577.1_Missense_Mutation_p.D577G	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	641					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TTCCTCTGGATCGAGGGGCTC	0.498			T	PAX5	ALL								21	45					0	0	1	0	0	C	71008510	T	C	71008510	3	2	48	1	0	0	0	0	1	0	0	0	6059	1435	50	4	115	4	FOXP1	3	71008510	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1837041	71008510	127013920	962	5356										
FOXP1	27086	broad.mit.edu	37	chr3	71021810	71021810	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacacttgtgaagactaagAttatgacgcactgcattctg	8	8	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:71021810A>C	ENST00000318789.4	-	18	2073	c.1548T>G	c.(1546-1548)aaT>aaG	p.N516K	FOXP1_ENST00000493089.1_Missense_Mutation_p.N515K|FOXP1_ENST00000475937.1_Missense_Mutation_p.N516K|FOXP1_ENST00000498215.1_Missense_Mutation_p.N516K|FOXP1_ENST00000491238.1_Missense_Mutation_p.N518K|FOXP1_ENST00000484350.1_Missense_Mutation_p.N440K|FOXP1_ENST00000468577.1_Intron	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	516					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GAAGACTAAGATTATGACGCA	0.378			T	PAX5	ALL								15	22					0	0	1	0	0	C	71021810	A	C	71021810	3	2	48	1	0	0	0	0	1	0	0	0	6059	330	12	4	501	4	FOXP1	3	71021810	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	13300	71021810	127000620	963	5357										
PPP4R2	151987	broad.mit.edu	37	chr3	73114163	73114163	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagtcaaacgacttccagcGaaatttcttcagttatggta	7	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:73114163G>A	ENST00000356692.5	+	8	1052	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	PPP4R2_ENST00000295862.9_Missense_Mutation_p.E211K|PPP4R2_ENST00000394284.3_Missense_Mutation_p.E210K			Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	267					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			breast(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)|urinary_tract(2)	12		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		GACTTCCAGCGAAATTTCTTC	0.448													16	41					0	0	1	0	0	A	73114163	G	A	73114163	3	1	48	1	0	0	0	0	1	0	0	0	12452	1059	37	1	829	1	PPP4R2	3	73114163	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2092353	73114163	124908267	964	5358										
ROBO2	6092	broad.mit.edu	37	chr3	77645854	77645854	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccacgagcttgccagtaaAtaatagcaacagtggcccaa	9	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:77645854A>G	ENST00000461745.1	+	19	3707	c.2807A>G	c.(2806-2808)aAt>aGt	p.N936S	ROBO2_ENST00000332191.8_Missense_Mutation_p.N936S|ROBO2_ENST00000487694.3_Missense_Mutation_p.N952S	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	936					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TTGCCAGTAAATAATAGCAAC	0.418													38	59					0	0	1	0	0	G	77645854	A	G	77645854	3	3	48	1	0	0	0	0	1	0	0	0	13565	101	4	4	2883	4	ROBO2	3	77645854	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4531691	77645854	120376576	965	5359										
EPHA3	2042	broad.mit.edu	37	chr3	89259557	89259557	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggtcttgtgtcaacaattCtaaggaggaagatcctccaa	10	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:89259557C>A	ENST00000336596.2	+	3	926	c.701C>A	c.(700-702)tCt>tAt	p.S234Y	EPHA3_ENST00000494014.1_Missense_Mutation_p.S234Y|EPHA3_ENST00000452448.2_Missense_Mutation_p.S234Y	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	234	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding	p.S234Y(2)		NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTCAACAATTCTAAGGAGGAA	0.488										TSP Lung(6;0.00050)			33	139					1.99505e-19	2.71627e-19	1	1	0	A	89259557	C	A	89259557	3	1	48	1	0	0	0	0	1	0	0	0	5196	913	32	2	711	2	EPHA3	3	89259557	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11613703	89259557	108762873	966	5360										
EPHA3	2042	broad.mit.edu	37	chr3	89478270	89478270	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctaggtaagccagttatgAttgtcacagaatacatggag	10	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:89478270A>C	ENST00000336596.2	+	12	2314	c.2089A>C	c.(2089-2091)Att>Ctt	p.I697L	EPHA3_ENST00000494014.1_Missense_Mutation_p.I697L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	697	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GCCAGTTATGATTGTCACAGA	0.289										TSP Lung(6;0.00050)			15	34					0	0	1	0	0	C	89478270	A	C	89478270	3	2	48	1	0	0	0	0	1	0	0	0	5196	333	12	4	2161	4	EPHA3	3	89478270	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	218713	89478270	108544160	967	5361										
EPHA3	2042	broad.mit.edu	37	chr3	89480399	89480399	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatgggctatgttcaccgaGacctcgctgctcggaacatc	10	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:89480399G>T	ENST00000336596.2	+	13	2461	c.2236G>T	c.(2236-2238)Gac>Tac	p.D746Y	EPHA3_ENST00000494014.1_Missense_Mutation_p.D746Y	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	746	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGTTCACCGAGACCTCGCTGC	0.498										TSP Lung(6;0.00050)			19	31					4.35082e-09	5.20082e-09	1	1	0	T	89480399	G	T	89480399	3	4	48	1	0	0	0	0	1	0	0	0	5196	942	33	2	2312	2	EPHA3	3	89480399	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2129	89480399	108542031	968	5362										
PROS1	5627	broad.mit.edu	37	chr3	93605179	93605179	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatacaagcttggatcattaCcggtttaatgagttcacttt	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:93605179C>T	ENST00000394236.3	-	11	1640		c.e11+1		PROS1_ENST00000407433.1_Splice_Site	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)						leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TGGATCATTACCGGTTTAATG	0.373													12	40					0	0	1	0	0	T	93605179	C	T	93605179	5	4	48	1	0	0	0	0	0	0	1	0	12609	521	18	3	726	3	PROS1	3	93605179	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4124780	93605179	104417251	969	5363										
PROS1	5627	broad.mit.edu	37	chr3	93617309	93617309	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctcacaactcttctgatCttgggcaagtttgaatcctt	6	11	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:93617309C>A	ENST00000394236.3	-	8	1148	c.832G>T	c.(832-834)Gat>Tat	p.D278Y	PROS1_ENST00000407433.1_Missense_Mutation_p.D147Y	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	278	EGF-like 4; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CTCTTCTGATCTTGGGCAAGT	0.383													24	36					1.10923e-09	1.34134e-09	1	1	0	A	93617309	C	A	93617309	3	1	48	1	0	0	0	0	1	0	0	0	12609	913	32	2	1230	2	PROS1	3	93617309	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12130	93617309	104405121	970	5364										
STX19	415117	broad.mit.edu	37	chr3	93733669	93733669	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgtgtcattgtatataaAcatgatttgctgaaaatggc	8	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:93733669A>G	ENST00000315099.2	-	2	701	c.445T>C	c.(445-447)Ttt>Ctt	p.F149L	ARL13B_ENST00000471138.1_Intron|ARL13B_ENST00000535334.1_Intron|ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000486562.1_Intron|ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000394222.3_Intron	NM_001001850.2	NP_001001850.1	Q8N4C7	STX19_HUMAN	syntaxin 19	149					intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity			kidney(2)|large_intestine(2)|lung(4)|prostate(1)	9						TTGTATATAAACATGATTTGC	0.378													6	99					0	0	1	0	0	G	93733669	A	G	93733669	3	3	48	1	0	0	0	0	1	0	0	0	15397	43	2	4	443	4	STX19	3	93733669	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	116360	93733669	104288761	971	5365										
EPHA6	285220	broad.mit.edu	37	chr3	97198185	97198185	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagtcagaagagaagagaaGaaaccacttacagaatgggc	12	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:97198185G>T	ENST00000389672.5	+	9	2089	c.2051G>T	c.(2050-2052)aGa>aTa	p.R684I	EPHA6_ENST00000502694.1_Missense_Mutation_p.R76I|EPHA6_ENST00000514100.1_Missense_Mutation_p.R76I|EPHA6_ENST00000442602.2_Missense_Mutation_p.R50I	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	589	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GAGAAGAGAAGAAACCACTTA	0.333													3	13					0.00909568	0.00935351	1	1	0	T	97198185	G	T	97198185	3	4	48	1	0	0	0	0	1	0	0	0	5199	942	33	2	2153	2	EPHA6	3	97198185	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3464516	97198185	100824245	972	5366										
CRYBG3	131544	broad.mit.edu	37	chr3	97618005	97618005	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgcctaccagcaaaagttCttctgtggagaacaatacat	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:97618005C>A	ENST00000182096.4	+	11	2089	c.2025C>A	c.(2023-2025)ttC>ttA	p.F675L		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						AGCAAAAGTTCTTCTGTGGAG	0.333													20	28					1.33834e-09	1.61283e-09	1	1	0	A	97618005	C	A	97618005	3	1	48	1	0	0	0	0	1	0	0	0	3936	912	32	2	2067	2	CRYBG3	3	97618005	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	419820	97618005	100404425	973	5367										
CRYBG3	131544	broad.mit.edu	37	chr3	97655650	97655650	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatagcttatgaaggatcCaatttcttgggaagacaaat	10	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:97655650C>A	ENST00000182096.4	+	16	2623	c.2559C>A	c.(2557-2559)tcC>tcA	p.S853S	CRYBG3_ENST00000389622.2_Silent_p.S60S|CRYBG3_ENST00000485253.1_3'UTR	NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						ATGAAGGATCCAATTTCTTGG	0.393													14	18					3.35478e-16	4.45534e-16	1	1	0	A	97655650	C	A	97655650	2	1	48	1	0	0	0	0	0	0	0	1	3936	581	21	5		5	CRYBG3	3	97655650	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	37645	97655650	100366780	974	5368										
OR5K1	26339	broad.mit.edu	37	chr3	98188675	98188675	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaaaatgttagagaacttCttttctgagaacaaaaggat	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:98188675C>A	ENST00000332650.5	+	1	352	c.255C>A	c.(253-255)ttC>ttA	p.F85L		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TAGAGAACTTCTTTTCTGAGA	0.433													58	117					2.40265e-35	3.4535e-35	1	1	0	A	98188675	C	A	98188675	3	1	48	1	0	0	0	0	1	0	0	0	11212	912	32	2	257	2	OR5K1	3	98188675	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	533025	98188675	99833755	975	5369										
OR5K1	26339	broad.mit.edu	37	chr3	98188696	98188696	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctgagaacaaaaggatTtccctctatgaatgtgcagt	8	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:98188696T>G	ENST00000332650.5	+	1	373	c.276T>G	c.(274-276)atT>atG	p.I92M		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACAAAAGGATTTCCCTCTATG	0.433													65	109					0	0	1	0	0	G	98188696	T	G	98188696	3	3	48	1	0	0	0	0	1	0	0	0	11212	1829	64	4	278	4	OR5K1	3	98188696	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	21	98188696	99833734	976	5370										
CLDND1	56650	broad.mit.edu	37	chr3	98237781	98237781	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccgggatcaacaaatttCtccatgaactgctcagttag	7	10	3	1	rs141592597	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:98237781C>A	ENST00000503004.1	-	3	1230	c.351G>T	c.(349-351)gaG>gaT	p.E117D	CLDND1_ENST00000510545.1_Missense_Mutation_p.E117D|CLDND1_ENST00000394180.2_Missense_Mutation_p.E117D|CLDND1_ENST00000513287.1_Missense_Mutation_p.E117D|CLDND1_ENST00000394181.2_Missense_Mutation_p.E117D|CLDND1_ENST00000502288.1_Missense_Mutation_p.E22D|CLDND1_ENST00000511081.1_Missense_Mutation_p.E22D|CLDND1_ENST00000508503.1_5'UTR|CLDND1_ENST00000437922.1_Missense_Mutation_p.E140D|CLDND1_ENST00000394185.2_Missense_Mutation_p.E117D|CLDND1_ENST00000341181.6_Missense_Mutation_p.E117D|CLDND1_ENST00000507874.1_Missense_Mutation_p.E117D			Q9NY35	CLDN1_HUMAN	claudin domain containing 1	117						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	9						CAACAAATTTCTCCATGAACT	0.388													5	17					0.000602214	0.000636035	1	1	0	A	98237781	C	A	98237781	3	1	48	1	0	0	0	0	1	0	0	0	3516	912	32	2	422	2	CLDND1	3	98237781	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	49085	98237781	99784649	977	5371										
GPR15	2838	broad.mit.edu	37	chr3	98251633	98251633	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcgtggcagcctttcttgtCtcctggctgcccttcaatac	9	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:98251633C>A	ENST00000284311.3	+	1	891	c.756C>A	c.(754-756)gtC>gtA	p.V252V		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	252						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CCTTTCTTGTCTCCTGGCTGC	0.453													26	53					4.26978e-12	5.35675e-12	1	1	0	A	98251633	C	A	98251633	2	1	48	1	0	0	0	0	0	0	0	1	6694	900	32	2		2	GPR15	3	98251633	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13852	98251633	99770797	978	5372										
GPR128	84873	broad.mit.edu	37	chr3	100352109	100352109	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaatttctttgtattaaagCgggcaatccaatggcagtcc	8	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:100352109C>T	ENST00000273352.3	+	4	603	c.334_splice	c.e4-1	p.A112_splice		NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	112					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						TGTATTAAAGCGGGCAATCCA	0.269													10	15					0	0	1	0	0	T	100352109	C	T	100352109	5	4	48	1	0	0	0	0	0	0	1	0	6680	782	27	1	349	1	GPR128	3	100352109	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2100476	100352109	97670321	979	5373										
IMPG2	50939	broad.mit.edu	37	chr3	100947714	100947714	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaactctcattctctcttGaatttccttaaacaaaaaag	2	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:100947714G>T	ENST00000193391.7	-	18	3827	c.3640C>A	c.(3640-3642)Caa>Aaa	p.Q1214K		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1214	Hyaluronan-binding motif involved in chondroitin sulfate A- and C-binding motif (By similarity).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						ATTCTCTCTTGAATTTCCTTA	0.383													12	23					0.000978159	0.00102903	1	1	0	T	100947714	G	T	100947714	3	4	48	1	0	0	0	0	1	0	0	0	7772	1299	45	2	93	2	IMPG2	3	100947714	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	595605	100947714	97074716	980	5374										
IMPG2	50939	broad.mit.edu	37	chr3	101038599	101038599	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttggtagctagagaaaggtCtgttgattcttcaggcagga	13	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:101038599C>A	ENST00000193391.7	-	2	350	c.163G>T	c.(163-165)Gac>Tac	p.D55Y		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	55					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AGAGAAAGGTCTGTTGATTCT	0.423													7	83					5.18039e-06	5.75679e-06	1	1	0	A	101038599	C	A	101038599	3	1	48	1	0	0	0	0	1	0	0	0	7772	913	32	2	3634	2	IMPG2	3	101038599	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	90885	101038599	96983831	981	5375										
SENP7	57337	broad.mit.edu	37	chr3	101086730	101086730	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgagaatcaggtaaattatTtctaagccttctctttgtct	6	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:101086730T>G	ENST00000394095.2	-	8	975	c.922A>C	c.(922-924)Aat>Cat	p.N308H	SENP7_ENST00000394094.2_Missense_Mutation_p.N243H|SENP7_ENST00000394091.1_Missense_Mutation_p.N144H|SENP7_ENST00000314261.7_Missense_Mutation_p.N242H|SENP7_ENST00000348610.3_Missense_Mutation_p.N275H|SENP7_ENST00000358203.3_Missense_Mutation_p.N144H	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	308					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GGTAAATTATTTCTAAGCCTT	0.328													35	43					0	0	1	0	0	G	101086730	T	G	101086730	3	3	48	1	0	0	0	0	1	0	0	0	14104	1841	64	4	2298	4	SENP7	3	101086730	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	48131	101086730	96935700	982	5376										
ZBTB11	27107	broad.mit.edu	37	chr3	101390793	101390793	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagtacactagttacaaatCttaaagctgactggagagta	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:101390793C>A	ENST00000461821.1	-	2	778	c.575G>T	c.(574-576)aGa>aTa	p.R192I	ZBTB11_ENST00000312938.4_Intron			O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						AGTTACAAATCTTAAAGCTGA	0.378													4	29					0.00909568	0.00935351	1	1	0	A	101390793	C	A	101390793	3	1	48	1	0	0	0	0	1	0	0	0	17582	928	32	2		2	ZBTB11	3	101390793	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	304063	101390793	96631637	983	5377										
CEP97	79598	broad.mit.edu	37	chr3	101451471	101451471	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctaaacctcagagtcctagAtggatatgtgatttctcaga	8	9	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:101451471A>C	ENST00000341893.3	+	6	1453	c.701A>C	c.(700-702)gAt>gCt	p.D234A	CEP97_ENST00000462076.1_3'UTR|CEP97_ENST00000494050.1_Missense_Mutation_p.D234A|CEP97_ENST00000327230.4_Missense_Mutation_p.D234A			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	234	LRRCT.					centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						AGAGTCCTAGATGGATATGTG	0.403													7	20					0	0	1	0	0	C	101451471	A	C	101451471	3	2	48	1	0	0	0	0	1	0	0	0	3285	333	12	4	723	4	CEP97	3	101451471	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	60678	101451471	96570959	984	5378										
ZPLD1	131368	broad.mit.edu	37	chr3	102187875	102187875	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcggggccggttttcttttGaagtgttccgatttgtgaaa	13	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:102187875G>T	ENST00000306176.1	+	8	977	c.877G>T	c.(877-879)Gaa>Taa	p.E293*	ZPLD1_ENST00000491959.1_Nonsense_Mutation_p.E277*|ZPLD1_ENST00000466937.1_Nonsense_Mutation_p.E277*	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	277	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GTTTTCTTTTGAAGTGTTCCG	0.478													16	41					1.3612e-06	1.53357e-06	1	1	0	T	102187875	G	T	102187875	4	4	48	1	0	0	0	0	0	1	0	0	18262	1291	45	2	907	2	ZPLD1	3	102187875	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	736404	102187875	95834555	985	5379										
CBLB	868	broad.mit.edu	37	chr3	105452861	105452861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatgattatacctgccatgCcgtaaggcaagaggtgcaca	10	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:105452861C>T	ENST00000264122.4	-	9	1516	c.1195G>A	c.(1195-1197)Gca>Aca	p.A399T	CBLB_ENST00000405772.1_Missense_Mutation_p.A399T|CBLB_ENST00000403724.1_Missense_Mutation_p.A399T|CBLB_ENST00000394027.3_Missense_Mutation_p.A421T|CBLB_ENST00000545639.1_3'UTR	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	399					cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						ACCTGCCATGCCGTAAGGCAA	0.393			Mis S		AML								15	32					0	0	1	0	0	T	105452861	C	T	105452861	3	4	48	1	0	0	0	0	1	0	0	0	2719	739	26	3	1797	3	CBLB	3	105452861	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3264986	105452861	92569569	986	5380										
CBLB	868	broad.mit.edu	37	chr3	105586436	105586436	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccatctggaattttagttCtttaaaaggcagatttaaaa	7	5	2	1	rs55944080		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:105586436C>T	ENST00000264122.4	-	2	308		c.e2-1		CBLB_ENST00000405772.1_Splice_Site|CBLB_ENST00000403724.1_Splice_Site|CBLB_ENST00000394027.3_Splice_Site|CBLB_ENST00000545639.1_Splice_Site	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase						cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						AATTTTAGTTCTTTAAAAGGC	0.373			Mis S		AML								11	27					0	0	1	0	0	T	105586436	C	T	105586436	5	4	48	1	0	0	0	0	0	0	1	0	2719	927	32	3		3	CBLB	3	105586436	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	133575	105586436	92435994	987	5381										
BBX	56987	broad.mit.edu	37	chr3	107492183	107492183	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcaagagagaagaaaatgTcaaaggagaaatcctcagac	9	6	3	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:107492183T>G	ENST00000415149.2	+	11	1942	c.1615T>G	c.(1615-1617)Tca>Gca	p.S539A	BBX_ENST00000406780.1_Missense_Mutation_p.S539A|BBX_ENST00000402543.1_Missense_Mutation_p.S539A|BBX_ENST00000416476.2_Intron|BBX_ENST00000325805.8_Missense_Mutation_p.S539A	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	539	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GAAGAAAATGTCAAAGGAGAA	0.443													29	53					0	0	1	0	0	G	107492183	T	G	107492183	3	3	48	1	0	0	0	0	1	0	0	0	1341	1667	58	4	1645	4	BBX	3	107492183	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1905747	107492183	90530247	988	5382										
MORC1	27136	broad.mit.edu	37	chr3	108724067	108724067	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctcttctatgtttcttttCtgtcctctacggctcgctga	7	12	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:108724067C>A	ENST00000232603.5	-	19	1945	c.1863G>T	c.(1861-1863)caG>caT	p.Q621H	MORC1_ENST00000483760.1_Missense_Mutation_p.Q600H	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	621					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TGTTTCTTTTCTGTCCTCTAC	0.378													12	26					3.27435e-08	3.83577e-08	1	1	0	A	108724067	C	A	108724067	3	1	48	1	0	0	0	0	1	0	0	0	9749	912	32	2	1131	2	MORC1	3	108724067	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1231884	108724067	89298363	989	5383										
PHLDB2	90102	broad.mit.edu	37	chr3	111603511	111603511	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccgcctcctatcagcagatCgggagccgcaagcatgcctt	10	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:111603511C>T	ENST00000431670.2	+	2	998	c.587C>T	c.(586-588)tCg>tTg	p.S196L	PHLDB2_ENST00000412622.1_Missense_Mutation_p.S196L|PHLDB2_ENST00000393923.3_Missense_Mutation_p.S223L|PHLDB2_ENST00000477695.1_Missense_Mutation_p.S196L|PHLDB2_ENST00000478922.1_Missense_Mutation_p.S196L|PHLDB2_ENST00000393925.3_Missense_Mutation_p.S196L|PHLDB2_ENST00000481953.1_Missense_Mutation_p.S196L	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	196						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						ATCAGCAGATCGGGAGCCGCA	0.562													27	52					0	0	1	0	0	T	111603511	C	T	111603511	3	4	48	1	0	0	0	0	1	0	0	0	11899	893	31	1	674	1	PHLDB2	3	111603511	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2879444	111603511	86418919	990	5384										
PHLDB2	90102	broad.mit.edu	37	chr3	111671466	111671466	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacagcataaagaaggcctCtatctgagtgatactttgcc	8	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:111671466C>A	ENST00000431670.2	+	11	3090	c.2679C>A	c.(2677-2679)ctC>ctA	p.L893L	PHLDB2_ENST00000412622.1_Silent_p.L850L|PHLDB2_ENST00000393923.3_Silent_p.L877L|PHLDB2_ENST00000393925.3_Silent_p.L893L|PHLDB2_ENST00000495180.1_Intron|PHLDB2_ENST00000481953.1_Silent_p.L850L	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	893						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						AAGAAGGCCTCTATCTGAGTG	0.408													36	46					9.8876e-21	1.35804e-20	1	1	0	A	111671466	C	A	111671466	2	1	48	1	0	0	0	0	0	0	0	1	11899	900	32	2		2	PHLDB2	3	111671466	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67955	111671466	86350964	991	5385										
CCDC80	151887	broad.mit.edu	37	chr3	112335658	112335658	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcgggactggaaagtatcGatcagatcaaacacagactt	9	8	2	2	rs141976023		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:112335658G>A	ENST00000206423.3	-	5	3173	c.2220C>T	c.(2218-2220)atC>atT	p.I740I	CCDC80_ENST00000439685.2_Silent_p.I740I	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	740										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GGAAAGTATCGATCAGATCAA	0.388													30	36					0	0	1	0	0	A	112335658	G	A	112335658	2	1	48	1	0	0	0	0	0	0	0	1	2874	1048	37	1		1	CCDC80	3	112335658	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	664192	112335658	85686772	992	5386										
CD200R1L	344807	broad.mit.edu	37	chr3	112545866	112545866	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaactttacggacagactcTtgttgccagtcaaatgggag	10	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:112545866T>G	ENST00000488794.1	-	6	1179	c.590A>C	c.(589-591)aAg>aCg	p.K197T	CD200R1L_ENST00000398214.1_Missense_Mutation_p.K218T|CD200R1L_ENST00000448932.1_Missense_Mutation_p.K197T			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	218	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						GGACAGACTCTTGTTGCCAGT	0.453													25	50					0	0	1	0	0	G	112545866	T	G	112545866	3	3	48	1	0	0	0	0	1	0	0	0	3004	1609	56	4	174	4	CD200R1L	3	112545866	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	210208	112545866	85476564	993	5387										
CD200R1	131450	broad.mit.edu	37	chr3	112693688	112693688	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagccctaggttagcagttCtccaagggcagagcatttct	11	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:112693688C>A	ENST00000471858.1	-	1	249	c.17G>T	c.(16-18)aGa>aTa	p.R6I	CD200R1_ENST00000308611.3_Missense_Mutation_p.R6I|CD200R1_ENST00000490004.1_Missense_Mutation_p.R6I|CD200R1_ENST00000440122.2_Missense_Mutation_p.R6I|CD200R1_ENST00000295863.4_Missense_Mutation_p.R6I	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	6					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity	p.R6I(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						GTTAGCAGTTCTCCAAGGGCA	0.468													16	25					1.33834e-09	1.61283e-09	1	1	0	A	112693688	C	A	112693688	3	1	48	1	0	0	0	0	1	0	0	0	3003	913	32	2	1108	2	CD200R1	3	112693688	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	147822	112693688	85328742	994	5388										
SIDT1	54847	broad.mit.edu	37	chr3	113327383	113327383	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attattccaacttccaattcGgtaattagaacttatatcta	3	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113327383G>A	ENST00000264852.4	+	17	2446	c.1720_splice	c.e17+1	p.D574_splice	SIDT1_ENST00000393830.3_Splice_Site_p.D574_splice|SIDT1_ENST00000463226.1_3'UTR	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	574						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						CTTCCAATTCGGTAATTAGAA	0.423													29	50					0	0	1	0	0	A	113327383	G	A	113327383	5	1	48	1	0	0	0	0	0	0	1	0	14356	1130	39	1	1786	1	SIDT1	3	113327383	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	633695	113327383	84695047	995	5389										
KIAA2018	205717	broad.mit.edu	37	chr3	113374248	113374248	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgggatgagggctggagttCgagtggcactaggctgagta	18	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113374248C>T	ENST00000316407.4	-	7	6691	c.6281G>A	c.(6280-6282)cGa>cAa	p.R2094Q	KIAA2018_ENST00000478658.1_Missense_Mutation_p.R2094Q|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	2094					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GGCTGGAGTTCGAGTGGCACT	0.443													21	50					0	0	1	0	0	T	113374248	C	T	113374248	3	4	48	1	0	0	0	0	1	0	0	0	8309	884	31	1	460	1	KIAA2018	3	113374248	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	46865	113374248	84648182	996	5390										
KIAA2018	205717	broad.mit.edu	37	chr3	113375981	113375981	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgcatctgaacttcctgTtgcagagtcctctgttggtg	10	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113375981T>C	ENST00000316407.4	-	7	4958	c.4548A>G	c.(4546-4548)caA>caG	p.Q1516Q	KIAA2018_ENST00000478658.1_Silent_p.Q1516Q|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1516	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GAACTTCCTGTTGCAGAGTCC	0.483													19	31					0	0	1	0	0	C	113375981	T	C	113375981	2	2	48	1	0	0	0	0	0	0	0	1	8309	1722	60	4		4	KIAA2018	3	113375981	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1733	113375981	84646449	997	5391										
KIAA2018	205717	broad.mit.edu	37	chr3	113379382	113379382	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagtgcttataggaatggTggccttccctactccagggg	13	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113379382T>C	ENST00000316407.4	-	7	1557	c.1147A>G	c.(1147-1149)Acc>Gcc	p.T383A	KIAA2018_ENST00000478658.1_Missense_Mutation_p.T383A|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	383					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ATAGGAATGGTGGCCTTCCCT	0.443													4	60					0	0	1	0	0	C	113379382	T	C	113379382	3	2	48	1	0	0	0	0	1	0	0	0	8309	1696	59	4	5594	4	KIAA2018	3	113379382	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3401	113379382	84643048	998	5392										
GRAMD1C	54762	broad.mit.edu	37	chr3	113627897	113627897	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaactagagtgccatcaaaGtcactggacttgaataaaaa	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113627897G>T	ENST00000358160.4	+	9	1374	c.882G>T	c.(880-882)aaG>aaT	p.K294N	GRAMD1C_ENST00000472026.1_Missense_Mutation_p.K127N|GRAMD1C_ENST00000452134.2_5'UTR|GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000440446.2_Missense_Mutation_p.K89N	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	294						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						TGCCATCAAAGTCACTGGACT	0.333													20	37					1.55795e-14	2.03067e-14	1	1	0	T	113627897	G	T	113627897	3	4	48	1	0	0	0	0	1	0	0	0	6789	1020	36	5	916	5	GRAMD1C	3	113627897	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	248515	113627897	84394533	999	5393										
GRAMD1C	54762	broad.mit.edu	37	chr3	113634593	113634593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaagactttttatcaaccGtatttttcatatcagtgctg	7	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113634593G>A	ENST00000358160.4	+	10	1490	c.998G>A	c.(997-999)cGt>cAt	p.R333H	GRAMD1C_ENST00000472026.1_Missense_Mutation_p.R166H|GRAMD1C_ENST00000452134.2_Missense_Mutation_p.R62H|GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000440446.2_Missense_Mutation_p.R128H	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	333						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						TTTATCAACCGTATTTTTCAT	0.323													10	28					0	0	1	0	0	A	113634593	G	A	113634593	3	1	48	1	0	0	0	0	1	0	0	0	6789	1145	40	1	1036	1	GRAMD1C	3	113634593	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6696	113634593	84387837	1000	5394										
QTRTD1	79691	broad.mit.edu	37	chr3	113789594	113789594	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgatggagaagtatcttgtaAggaagcaacttccataaaaa	9	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:113789594A>C	ENST00000281273.4	+	6	712	c.455A>C	c.(454-456)aAg>aCg	p.K152T	QTRTD1_ENST00000485050.1_Missense_Mutation_p.K164T|QTRTD1_ENST00000479882.1_Missense_Mutation_p.K29T|QTRTD1_ENST00000466050.1_3'UTR|QTRTD1_ENST00000493014.1_Missense_Mutation_p.K46T	NM_024638.3	NP_078914.1	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain containing 1	152					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|skin(2)	10						GTATCTTGTAAGGAAGCAACT	0.483													27	44					0	0	1	0	0	C	113789594	A	C	113789594	3	2	48	1	0	0	0	0	1	0	0	0	12937	72	3	4	469	4	QTRTD1	3	113789594	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	155001	113789594	84232836	1001	5395										
ZBTB20	26137	broad.mit.edu	37	chr3	114057897	114057897	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtggtcgttgaactgctcGatttggtcaaactttgctgg	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:114057897G>A	ENST00000462705.1	-	12	2783	c.1962C>T	c.(1960-1962)atC>atT	p.I654I	ZBTB20_ENST00000357258.3_Silent_p.I654I|ZBTB20_ENST00000474710.1_Silent_p.I727I|ZBTB20_ENST00000393785.2_Silent_p.I654I|ZBTB20_ENST00000481632.1_Silent_p.I654I|ZBTB20_ENST00000471418.1_Silent_p.I654I|ZBTB20_ENST00000464560.1_Silent_p.I654I	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	727					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGAACTGCTCGATTTGGTCAA	0.522													29	63					0	0	1	0	0	A	114057897	G	A	114057897	2	1	48	1	0	0	0	0	0	0	0	1	17587	1048	37	1		1	ZBTB20	3	114057897	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	268303	114057897	83964533	1002	5396										
C3orf30	152405	broad.mit.edu	37	chr3	118865185	118865185	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agataaccacactgctcacaGaatagctgaccagactgccc	7	14	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:118865185G>A	ENST00000295622.1	+	1	189	c.149G>A	c.(148-150)aGa>aAa	p.R50K		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	50										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		ACTGCTCACAGAATAGCTGAC	0.532													20	48					0	0	1	0	0	A	118865185	G	A	118865185	3	1	48	1	0	0	0	0	1	0	0	0	2234	942	33	3	151	3	C3orf30	3	118865185	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4807288	118865185	79157245	1003	5397										
C3orf30	152405	broad.mit.edu	37	chr3	118865848	118865848	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagttaggagaagaagttCtgagaagactgactacagat	12	4	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:118865848C>A	ENST00000295622.1	+	1	852	c.812C>A	c.(811-813)tCt>tAt	p.S271Y		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	271										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		AGAAGAAGTTCTGAGAAGACT	0.488													45	49					2.95478e-19	4.01807e-19	1	1	0	A	118865848	C	A	118865848	3	1	48	1	0	0	0	0	1	0	0	0	2234	913	32	2	814	2	C3orf30	3	118865848	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	663	118865848	79156582	1004	5398										
B4GALT4	8702	broad.mit.edu	37	chr3	118948740	118948740	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtcaagttctaccttcttCgtggatgcttcattagtcag	8	9	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:118948740C>T	ENST00000467604.1	-	3	598	c.207G>A	c.(205-207)acG>acA	p.T69T	B4GALT4_ENST00000359213.3_Silent_p.T69T|B4GALT4_ENST00000483209.1_Silent_p.T69T|B4GALT4_ENST00000460321.1_Intron|B4GALT4-AS1_ENST00000470790.1_RNA|B4GALT4_ENST00000471675.1_Silent_p.T22T|B4GALT4_ENST00000393765.2_Silent_p.T69T			O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4	69					membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(6)|skin(2)|stomach(2)	14				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)	CTACCTTCTTCGTGGATGCTT	0.388													4	42					0	0	1	0	0	T	118948740	C	T	118948740	2	4	48	1	0	0	0	0	0	0	0	1	1271	871	31	1		1	B4GALT4	3	118948740	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	82892	118948740	79073690	1005	5399										
ARHGAP31	57514	broad.mit.edu	37	chr3	119134773	119134773	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagagcgaccatctgggggtTctaagcctttccacaggtca	11	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:119134773T>C	ENST00000264245.4	+	12	4529	c.3997T>C	c.(3997-3999)Tct>Cct	p.S1333P		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1333					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						ATCTGGGGGTTCTAAGCCTTT	0.517													35	90					0	0	1	0	0	C	119134773	T	C	119134773	3	2	48	1	0	0	0	0	1	0	0	0	877	1783	62	4	4043	4	ARHGAP31	3	119134773	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	186033	119134773	78887657	1006	5400										
TMEM39A	55254	broad.mit.edu	37	chr3	119165904	119165904	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattgaggactgaatggcttCgaaagagattgacgagggtc	15	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:119165904C>T	ENST00000319172.5	-	5	956	c.536G>A	c.(535-537)cGa>cAa	p.R179Q	TMEM39A_ENST00000486159.1_Intron	NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	179						integral to membrane		p.R179Q(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		TGAATGGCTTCGAAAGAGATT	0.418													20	30					0	0	1	0	0	T	119165904	C	T	119165904	3	4	48	1	0	0	0	0	1	0	0	0	16220	884	31	1	950	1	TMEM39A	3	119165904	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31131	119165904	78856526	1007	5401										
CD80	941	broad.mit.edu	37	chr3	119256042	119256042	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatacttgatgagacacatGaagctgtggttggttgtcat	11	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:119256042G>T	ENST00000264246.3	-	4	1004	c.642C>A	c.(640-642)ttC>ttA	p.F214L	CD80_ENST00000383668.3_Intron|CD80_ENST00000383669.3_Missense_Mutation_p.F214L|CD80_ENST00000478182.1_Missense_Mutation_p.F214L	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	214	Ig-like C2-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	TGAGACACATGAAGCTGTGGT	0.388													31	66					2.61193e-14	3.39424e-14	1	1	0	T	119256042	G	T	119256042	3	4	48	1	0	0	0	0	1	0	0	0	3060	1281	45	2	236	2	CD80	3	119256042	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	90138	119256042	78766388	1008	5402										
ADPRH	141	broad.mit.edu	37	chr3	119306657	119306657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaactagaatacagaaacCggctggaagagacagctagg	12	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:119306657C>T	ENST00000478399.1	+	4	2411	c.1006C>T	c.(1006-1008)Cgg>Tgg	p.R336W	ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000478927.1_Missense_Mutation_p.R336W|ADPRH_ENST00000465513.1_Missense_Mutation_p.R336W|ADPRH_ENST00000357003.3_Missense_Mutation_p.R336W			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	336					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		ATACAGAAACCGGCTGGAAGA	0.448													24	64					0	0	1	0	0	T	119306657	C	T	119306657	3	4	48	1	0	0	0	0	1	0	0	0	330	643	23	1	1016	1	ADPRH	3	119306657	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	50615	119306657	78715773	1009	5403										
PLA1A	51365	broad.mit.edu	37	chr3	119316770	119316770	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagctcagcgatgcccccaGgtccctgggagagctgcttc	12	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:119316770G>T	ENST00000273371.4	+	1	82	c.10G>T	c.(10-12)Ggt>Tgt	p.G4C	PLA1A_ENST00000495992.1_Missense_Mutation_p.G4C|PLA1A_ENST00000488919.1_5'UTR	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A	4					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GATGCCCCCAGGTCCCTGGGA	0.542													4	14					0.00024832	0.000265255	1	1	0	T	119316770	G	T	119316770	3	4	48	1	0	0	0	0	1	0	0	0	12035	1000	35	5	12	5	PLA1A	3	119316770	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10113	119316770	78705660	1010	5404										
GTF2E1	2960	broad.mit.edu	37	chr3	120469578	120469578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttgatcggaagcaacttcGatcagttttgaataatttaa	8	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:120469578G>A	ENST00000283875.5	+	2	272	c.179G>A	c.(178-180)cGa>cAa	p.R60Q		NM_005513.2	NP_005504.2	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1, alpha 56kDa	60	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)	22				GBM - Glioblastoma multiforme(114;0.159)		AAGCAACTTCGATCAGTTTTG	0.453													23	41					0	0	1	0	0	A	120469578	G	A	120469578	3	1	48	1	0	0	0	0	1	0	0	0	6896	1058	37	1	181	1	GTF2E1	3	120469578	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1152808	120469578	77552852	1011	5405										
POLQ	10721	broad.mit.edu	37	chr3	121207791	121207791	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccatctgttgtattattttCtctgactgagtatccagata	7	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:121207791C>A	ENST00000264233.5	-	16	4115	c.3987G>T	c.(3985-3987)gaG>gaT	p.E1329D		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1329					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		GTATTATTTTCTCTGACTGAG	0.373								DNA polymerases (catalytic subunits)					23	37					1.55795e-14	2.03067e-14	1	1	0	A	121207791	C	A	121207791	3	1	48	1	0	0	0	0	1	0	0	0	12255	912	32	2	3845	2	POLQ	3	121207791	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	738213	121207791	76814639	1012	5406										
GOLGB1	2804	broad.mit.edu	37	chr3	121410023	121410023	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctgtgagacctttattttCtttggtgaccatgagtaatt	9	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:121410023C>A	ENST00000393667.3	-	14	8298	c.8188G>T	c.(8188-8190)Gaa>Taa	p.E2730*	GOLGB1_ENST00000340645.5_Nonsense_Mutation_p.E2725*	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2725					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		CCTTTATTTTCTTTGGTGACC	0.398													61	116					2.50483e-33	3.59302e-33	1	1	0	A	121410023	C	A	121410023	4	1	48	1	0	0	0	0	0	1	0	0	6603	922	32	2	1642	2	GOLGB1	3	121410023	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	202232	121410023	76612407	1013	5407										
GOLGB1	2804	broad.mit.edu	37	chr3	121416558	121416558	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggataataaatttagctgttCtttaagagtcttaatttcaa	6	4	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:121416558C>T	ENST00000393667.3	-	13	2922	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	GOLGB1_ENST00000340645.5_Missense_Mutation_p.E933K	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	933					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TTTAGCTGTTCTTTAAGAGTC	0.348													7	64					0	0	1	0	0	T	121416558	C	T	121416558	3	4	48	1	0	0	0	0	1	0	0	0	6603	922	32	3	7022	3	GOLGB1	3	121416558	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6535	121416558	76605872	1014	5408										
GOLGB1	2804	broad.mit.edu	37	chr3	121448762	121448762	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatccttctgtctaataaTatcttttagctccaccacca	2	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:121448762T>C	ENST00000393667.3	-	3	309	c.199A>G	c.(199-201)Att>Gtt	p.I67V	GOLGB1_ENST00000340645.5_Missense_Mutation_p.I67V|GOLGB1_ENST00000472829.1_5'UTR	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	67					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TGTCTAATAATATCTTTTAGC	0.383													23	33					0	0	1	0	0	C	121448762	T	C	121448762	3	2	48	1	0	0	0	0	1	0	0	0	6603	1406	49	4	9660	4	GOLGB1	3	121448762	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	32204	121448762	76573668	1015	5409										
CASR	846	broad.mit.edu	37	chr3	122002980	122002980	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctcaacctgcagttcctgCtggttttcctctgcaccttc	8	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:122002980C>T	ENST00000498619.1	+	7	2647	c.2209C>T	c.(2209-2211)Ctg>Ttg	p.L737L	CASR_ENST00000490131.1_Silent_p.L727L|CASR_ENST00000296154.5_Silent_p.L727L	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	727					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCAGTTCCTGCTGGTTTTCCT	0.567													18	41					0	0	1	0	0	T	122002980	C	T	122002980	2	4	48	1	0	0	0	0	0	0	0	1	2700	796	28	3		3	CASR	3	122002980	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	554218	122002980	76019450	1016	5410										
FAM162A	26355	broad.mit.edu	37	chr3	122121631	122121631	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttttaggttatgtgaaaGagatgtttcctcatctctaa	8	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:122121631G>T	ENST00000477892.1	+	2	143	c.59G>T	c.(58-60)aGa>aTa	p.R20I	FAM162A_ENST00000232125.5_Missense_Mutation_p.R10I|FAM162A_ENST00000469967.1_Missense_Mutation_p.R20I	NM_014367.3	NP_055182.3	Q96A26	F162A_HUMAN	family with sequence similarity 162, member A	20						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						TTATGTGAAAGAGATGTTTCC	0.373													8	21					0.00307968	0.00320271	1	1	0	T	122121631	G	T	122121631	3	4	48	1	0	0	0	0	1	0	0	0	5504	942	33	2	65	2	FAM162A	3	122121631	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	118651	122121631	75900799	1017	5411										
FAM162A	26355	broad.mit.edu	37	chr3	122121665	122121665	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctaaggcttaccagaagCtctgatttgaagagaataaa	8	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:122121665C>T	ENST00000477892.1	+	2	177	c.93C>T	c.(91-93)agC>agT	p.S31S	FAM162A_ENST00000232125.5_Silent_p.S21S|FAM162A_ENST00000469967.1_Silent_p.S31S	NM_014367.3	NP_055182.3	Q96A26	F162A_HUMAN	family with sequence similarity 162, member A	31						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						TTACCAGAAGCTCTGATTTGA	0.358													15	35					0	0	1	0	0	T	122121665	C	T	122121665	2	4	48	1	0	0	0	0	0	0	0	1	5504	796	28	3		3	FAM162A	3	122121665	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34	122121665	75900765	1018	5412										
PARP9	83666	broad.mit.edu	37	chr3	122255817	122255817	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacatttttcaaactgtttCttttgatctagaagctcttg	5	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:122255817C>A	ENST00000462315.1	-	9	2162	c.1869G>T	c.(1867-1869)aaG>aaT	p.K623N	PARP9_ENST00000492382.1_Missense_Mutation_p.K203N|PARP9_ENST00000360356.2_Missense_Mutation_p.K658N|PARP9_ENST00000477522.2_Missense_Mutation_p.K623N|PARP9_ENST00000471785.1_Missense_Mutation_p.K623N	NM_001146106.1	NP_001139578.1	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	658					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		CAAACTGTTTCTTTTGATCTA	0.353													39	69					1.93745e-38	2.79126e-38	1	1	0	A	122255817	C	A	122255817	3	1	48	1	0	0	0	0	1	0	0	0	11512	912	32	2	655	2	PARP9	3	122255817	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	134152	122255817	75766613	1019	5413										
SEMA5B	54437	broad.mit.edu	37	chr3	122630331	122630331	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatgaggtaggtccggtttCttttacctgcacagtcggtg	13	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:122630331C>A	ENST00000195173.4	-	21	3395	c.3092G>T	c.(3091-3093)aGa>aTa	p.R1031I	SEMA5B_ENST00000357599.3_Intron|SEMA5B_ENST00000451055.2_Intron			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GGTCCGGTTTCTTTTACCTGC	0.607													9	17					1.12685e-05	1.24509e-05	1	1	0	A	122630331	C	A	122630331	3	1	48	1	0	0	0	0	1	0	0	0	14091	928	32	2		2	SEMA5B	3	122630331	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	374514	122630331	75392099	1020	5414										
SEMA5B	54437	broad.mit.edu	37	chr3	122641234	122641234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcaggaagaggcgctgcgCgtcctgcaggctgcgctccg	15	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:122641234C>T	ENST00000195173.4	-	11	1636	c.1333G>A	c.(1333-1335)Gcg>Acg	p.A445T	SEMA5B_ENST00000357599.3_Missense_Mutation_p.A445T|SEMA5B_ENST00000451055.2_Missense_Mutation_p.A499T			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	445	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		AGGCGCTGCGCGTCCTGCAGG	0.701													8	12					0	0	1	0	0	T	122641234	C	T	122641234	3	4	48	1	0	0	0	0	1	0	0	0	14091	768	27	1	2174	1	SEMA5B	3	122641234	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10903	122641234	75381196	1021	5415										
MYLK	4638	broad.mit.edu	37	chr3	123383094	123383094	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctccaccttcatgtgctcGctttcctggatctaggggcg	10	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:123383094G>A	ENST00000360772.3	-	24	4221	c.3843C>T	c.(3841-3843)agC>agT	p.S1281S	MYLK_ENST00000360304.3_Silent_p.S1281S|MYLK_ENST00000475616.1_Silent_p.S1281S|MYLK_ENST00000354792.5_Silent_p.S81S|MYLK_ENST00000346322.5_Silent_p.S1212S|MYLK_ENST00000359169.1_Silent_p.S1281S			Q15746	MYLK_HUMAN	myosin light chain kinase	1281	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity	p.S1281S(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCATGTGCTCGCTTTCCTGGA	0.617													53	93					0	0	1	0	0	A	123383094	G	A	123383094	2	1	48	1	0	0	0	0	0	0	0	1	10103	1078	38	1		1	MYLK	3	123383094	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	741860	123383094	74639336	1022	5416										
KALRN	8997	broad.mit.edu	37	chr3	124141773	124141773	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatgcagagcagactcataAgcggctagagcagtgcctcc	11	12	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:124141773A>C	ENST00000360013.3	+	15	2778	c.2651A>C	c.(2650-2652)aAg>aCg	p.K884T	KALRN_ENST00000240874.3_Missense_Mutation_p.K884T|KALRN_ENST00000460856.1_Missense_Mutation_p.K884T	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	884					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CAGACTCATAAGCGGCTAGAG	0.502													7	78					0	0	1	0	0	C	124141773	A	C	124141773	3	2	48	1	0	0	0	0	1	0	0	0	8018	72	3	4	2709	4	KALRN	3	124141773	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	758679	124141773	73880657	1023	5417										
MUC13	56667	broad.mit.edu	37	chr3	124642454	124642454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgcagcttaacacataacGaattatctgcacagggatca	7	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:124642454G>A	ENST00000311075.3	-	3	592	c.554C>T	c.(553-555)tCg>tTg	p.S185L		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	185	EGF-like 1.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						AACACATAACGAATTATCTGC	0.383													18	43					0	0	1	0	0	A	124642454	G	A	124642454	3	1	48	1	0	0	0	0	1	0	0	0	10018	1059	37	1	1017	1	MUC13	3	124642454	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	500681	124642454	73379976	1024	5418										
HEG1	57493	broad.mit.edu	37	chr3	124720800	124720800	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccaggtcaaatagcgtcAcattggaggccagggaaaag	13	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:124720800A>G	ENST00000311127.4	-	11	3480	c.3413T>C	c.(3412-3414)gTg>gCg	p.V1138A		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	1138						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						AAATAGCGTCACATTGGAGGC	0.502													13	24					0	0	1	0	0	G	124720800	A	G	124720800	3	3	48	1	0	0	0	0	1	0	0	0	7084	159	6	4	760	4	HEG1	3	124720800	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	78346	124720800	73301630	1025	5419										
CCDC37	348807	broad.mit.edu	37	chr3	126137314	126137314	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagcagaaaagaatgtggaGcctgagaacatgagtggcta	13	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:126137314G>A	ENST00000393425.1	+	6	534	c.435G>A	c.(433-435)gaG>gaA	p.E145E	CCDC37_ENST00000505024.1_Silent_p.E145E|CCDC37_ENST00000352312.1_Silent_p.E144E			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	144										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		AGAATGTGGAGCCTGAGAACA	0.612													28	61					0	0	1	0	0	A	126137314	G	A	126137314	2	1	48	1	0	0	0	0	0	0	0	1	2828	962	34	3		3	CCDC37	3	126137314	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1416514	126137314	71885116	1026	5420										
ZXDC	79364	broad.mit.edu	37	chr3	126180490	126180490	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttccttcctgctgcccaActgctcctgggcgagaaggc	12	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:126180490A>G	ENST00000389709.3	-	6	2068	c.2015T>C	c.(2014-2016)gTt>gCt	p.V672A	ZXDC_ENST00000336332.5_Missense_Mutation_p.V672A	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	672	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		CTGCTGCCCAACTGCTCCTGG	0.642													32	60					0	0	1	0	0	G	126180490	A	G	126180490	3	3	48	1	0	0	0	0	1	0	0	0	18291	43	2	4	587	4	ZXDC	3	126180490	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	43176	126180490	71841940	1027	5421										
SEC61A1	29927	broad.mit.edu	37	chr3	127785899	127785899	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaacatccccatcatcctgCagtctgccctggtgtccaac	6	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:127785899C>T	ENST00000243253.3	+	9	1064	c.880C>T	c.(880-882)Cag>Tag	p.Q294*	RUVBL1_ENST00000464873.1_Intron|SEC61A1_ENST00000483956.1_3'UTR|SEC61A1_ENST00000464451.1_Nonsense_Mutation_p.Q300*|SEC61A1_ENST00000424880.2_Nonsense_Mutation_p.Q174*	NM_013336.3	NP_037468.1	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit (S. cerevisiae)	294					protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|prostate(4)	21						CATCATCCTGCAGTCTGCCCT	0.557													18	94					0	0	1	0	0	T	127785899	C	T	127785899	4	4	48	1	0	0	0	0	0	1	0	0	14053	711	25	3	914	3	SEC61A1	3	127785899	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1605409	127785899	70236531	1028	5422										
KIAA1257	57501	broad.mit.edu	37	chr3	128696954	128696954	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggatgttcctggttcgactCttctctgacaatgttggtat	10	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:128696954C>A	ENST00000265068.5	-	5	909	c.742G>T	c.(742-744)Gag>Tag	p.E248*	KIAA1257_ENST00000510149.1_5'UTR|KIAA1257_ENST00000511438.1_Nonsense_Mutation_p.E248*|KIAA1257_ENST00000515659.1_Nonsense_Mutation_p.E136*	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	248										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						TGGTTCGACTCTTCTCTGACA	0.418													11	41					2.27111e-07	2.60515e-07	1	1	0	A	128696954	C	A	128696954	4	1	48	1	0	0	0	0	0	1	0	0	8259	922	32	2	503	2	KIAA1257	3	128696954	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	911055	128696954	69325476	1029	5423										
H1FX	8971	broad.mit.edu	37	chr3	129034193	129034193	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccgccgtcttcttggcctTgccgcctttgtccttcttgg	11	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:129034193T>G	ENST00000333762.4	-	1	927	c.553A>C	c.(553-555)Aag>Cag	p.K185Q		NM_006026.3	NP_006017.1	Q92522	H1X_HUMAN	H1 histone family, member X	185					nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)|ovary(1)|urinary_tract(2)	4						TTCTTGGCCTTGCCGCCTTTG	0.706													11	26					0	0	1	0	0	G	129034193	T	G	129034193	3	3	48	1	0	0	0	0	1	0	0	0	6963	1821	63	4	92	4	H1FX	3	129034193	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	337239	129034193	68988237	1030	5424										
MBD4	8930	broad.mit.edu	37	chr3	129155479	129155479	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgagtctttggctgaacaAaatttgtttatgatgccaga	9	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:129155479A>T	ENST00000429544.2	-	3	1203	c.1008T>A	c.(1006-1008)ttT>ttA	p.F336L	MBD4_ENST00000503197.1_Missense_Mutation_p.F336L|MBD4_ENST00000249910.1_Missense_Mutation_p.F336L|MBD4_ENST00000507208.1_Missense_Mutation_p.F336L|MBD4_ENST00000509587.1_Intron|MBD4_ENST00000393278.2_Intron	NM_001276270.1	NP_001263199.1	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	336					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)	22						TGGCTGAACAAAATTTGTTTA	0.338								Base excision repair (BER), DNA glycosylases					27	52					0	0	1	0	0	T	129155479	A	T	129155479	3	4	48	1	0	0	0	0	1	0	0	0	9395	11	1	4	758	4	MBD4	3	129155479	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	121286	129155479	68866951	1031	5425										
COL6A5	256076	broad.mit.edu	37	chr3	130189741	130189741	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaacaaatatcccaccgaaGatatgaaagccacatgtgtt	6	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:130189741G>T	ENST00000265379.6	+	39	7998	c.7504G>T	c.(7504-7506)Gat>Tat	p.D2502Y	COL6A5_ENST00000432398.2_Missense_Mutation_p.D2502Y			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2502	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						TCCCACCGAAGATATGAAAGC	0.428													10	17					1.33987e-11	1.67053e-11	1	1	0	T	130189741	G	T	130189741	3	4	48	1	0	0	0	0	1	0	0	0	3725	942	33	2	7654	2	COL6A5	3	130189741	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1034262	130189741	67832689	1032	5426										
COL6A6	131873	broad.mit.edu	37	chr3	130279266	130279266	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccatatttctgtgaaccaaGattccggtaaggaaaaactg	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:130279266G>T	ENST00000358511.6	+	1	89	c.58G>T	c.(58-60)Gat>Tat	p.D20Y	COL6A6_ENST00000453409.2_Missense_Mutation_p.D20Y	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	20	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGTGAACCAAGATTCCGGTAA	0.294													16	21					1.99824e-07	2.29918e-07	1	1	0	T	130279266	G	T	130279266	3	4	48	1	0	0	0	0	1	0	0	0	3726	942	33	2	60	2	COL6A6	3	130279266	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	89525	130279266	67743164	1033	5427										
ATP2C1	27032	broad.mit.edu	37	chr3	130698227	130698227	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggagtatcaataaaaatgAttactggagattcacaggag	10	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:130698227A>C	ENST00000510168.1	+	19	2255	c.1705A>C	c.(1705-1707)Att>Ctt	p.I569L	ATP2C1_ENST00000428331.2_Missense_Mutation_p.I569L|ATP2C1_ENST00000504948.1_Missense_Mutation_p.I553L|ATP2C1_ENST00000505330.1_Missense_Mutation_p.I553L|ATP2C1_ENST00000422190.2_Missense_Mutation_p.I569L|ATP2C1_ENST00000508532.1_Missense_Mutation_p.I569L|ATP2C1_ENST00000507488.2_Missense_Mutation_p.I553L|ATP2C1_ENST00000533801.2_Missense_Mutation_p.I564L|ATP2C1_ENST00000393221.4_Missense_Mutation_p.I603L|ATP2C1_ENST00000504381.1_Missense_Mutation_p.I514L|ATP2C1_ENST00000359644.3_Missense_Mutation_p.I569L|ATP2C1_ENST00000513801.1_Missense_Mutation_p.I553L|ATP2C1_ENST00000328560.8_Missense_Mutation_p.I569L			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	569					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	AATAAAAATGATTACTGGAGA	0.383									Hailey-Hailey disease				16	30					0	0	1	0	0	C	130698227	A	C	130698227	3	2	48	1	0	0	0	0	1	0	0	0	1142	333	12	4	1775	4	ATP2C1	3	130698227	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	418961	130698227	67324203	1034	5428										
ACPP	55	broad.mit.edu	37	chr3	132075553	132075553	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtactttgtggagatgtactAtcggaatgagacgcagcacg	13	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:132075553A>G	ENST00000336375.5	+	10	1082	c.992A>G	c.(991-993)tAt>tGt	p.Y331C	ACPP_ENST00000475741.1_Missense_Mutation_p.Y298C|ACPP_ENST00000351273.7_Missense_Mutation_p.Y331C	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	331						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						GAGATGTACTATCGGAATGAG	0.532													53	98					0	0	1	0	0	G	132075553	A	G	132075553	3	3	48	1	0	0	0	0	1	0	0	0	167	449	16	4	1030	4	ACPP	3	132075553	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1377326	132075553	65946877	1035	5429										
DNAJC13	23317	broad.mit.edu	37	chr3	132179159	132179159	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttctcttctctcgtcaaaGaagtttctggaaaacttact	6	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:132179159G>T	ENST00000260818.6	+	14	1763	c.1515G>T	c.(1513-1515)aaG>aaT	p.K505N	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	505							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TCTCGTCAAAGAAGTTTCTGG	0.308													14	18					1.49906e-05	1.64923e-05	1	1	0	T	132179159	G	T	132179159	3	4	48	1	0	0	0	0	1	0	0	0	4659	933	33	2	1565	2	DNAJC13	3	132179159	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	103606	132179159	65843271	1036	5430										
DNAJC13	23317	broad.mit.edu	37	chr3	132218600	132218600	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttacaagaggcatttagtcGctgtgtggctgtcttgactc	12	8	1	2	rs143638513	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:132218600G>A	ENST00000260818.6	+	38	4612	c.4364G>A	c.(4363-4365)cGc>cAc	p.R1455H		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1455							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						GCATTTAGTCGCTGTGTGGCT	0.418													44	121					0	0	1	0	0	A	132218600	G	A	132218600	3	1	48	1	0	0	0	0	1	0	0	0	4659	1087	38	1	4510	1	DNAJC13	3	132218600	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	39441	132218600	65803830	1037	5431										
NPHP3	27031	broad.mit.edu	37	chr3	132403475	132403475	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggagctaatgcacgtctccGaatatctaaagctctttcat	7	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:132403475G>A	ENST00000337331.5	-	24	3579	c.3493C>T	c.(3493-3495)Cgg>Tgg	p.R1165W	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	1165					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding	p.R1165W(1)		NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCACGTCTCCGAATATCTAAA	0.388													16	31					0	0	1	0	0	A	132403475	G	A	132403475	3	1	48	1	0	0	0	0	1	0	0	0	10626	1057	37	1	515	1	NPHP3	3	132403475	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	184875	132403475	65618955	1038	5432										
TMEM108	66000	broad.mit.edu	37	chr3	133099396	133099396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaggacaagccaggccttCgcagagcagcccaggggggt	15	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:133099396C>T	ENST00000515826.1	+	3	964	c.841C>T	c.(841-843)Cgc>Tgc	p.R281C	TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000393130.3_Missense_Mutation_p.R281C|TMEM108_ENST00000321871.6_Missense_Mutation_p.R281C			Q6UXF1	TM108_HUMAN	transmembrane protein 108	281						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GCCAGGCCTTCGCAGAGCAGC	0.647													23	29					0	0	1	0	0	T	133099396	C	T	133099396	3	4	48	1	0	0	0	0	1	0	0	0	16083	884	31	1	847	1	TMEM108	3	133099396	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	695921	133099396	64923034	1039	5433										
TF	7018	broad.mit.edu	37	chr3	133485143	133485143	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtattttgctatagcagtggTgaagaaatcagcttctgacc	10	7	2	3	rs142116896		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:133485143T>C	ENST00000402696.3	+	12	1837	c.1352T>C	c.(1351-1353)gTg>gCg	p.V451A	TF_ENST00000264998.3_Missense_Mutation_p.V324A	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	451	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	ATAGCAGTGGTGAAGAAATCA	0.493													72	100					0	0	1	0	0	C	133485143	T	C	133485143	3	2	48	1	0	0	0	0	1	0	0	0	15844	1696	59	4	1398	4	TF	3	133485143	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	385747	133485143	64537287	1040	5434										
SLCO2A1	6578	broad.mit.edu	37	chr3	133661613	133661613	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctgcagttcaaatagatCttcaagaggaaggggaggga	14	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:133661613C>T	ENST00000310926.4	-	11	1735		c.e11-1		SLCO2A1_ENST00000493729.1_Splice_Site	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1						sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						TCAAATAGATCTTCAAGAGGA	0.517													25	46					0	0	1	0	0	T	133661613	C	T	133661613	5	4	48	1	0	0	0	0	0	0	1	0	14780	927	32	3	486	3	SLCO2A1	3	133661613	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	176470	133661613	64360817	1041	5435										
SLCO2A1	6578	broad.mit.edu	37	chr3	133666229	133666229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgtagagagaaaacaaagCgcttcatgaggattcctcca	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:133666229C>T	ENST00000310926.4	-	9	1439	c.1166G>A	c.(1165-1167)cGc>cAc	p.R389H	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.R313H	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	389					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GAAAACAAAGCGCTTCATGAG	0.512													16	44					0	0	1	0	0	T	133666229	C	T	133666229	3	4	48	1	0	0	0	0	1	0	0	0	14780	768	27	1	789	1	SLCO2A1	3	133666229	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4616	133666229	64356201	1042	5436										
EPHB1	2047	broad.mit.edu	37	chr3	134880997	134880997	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacggcaagttcagtggcaaGatgtgcttccagactctgac	11	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:134880997G>A	ENST00000398015.3	+	7	1930	c.1560G>A	c.(1558-1560)aaG>aaA	p.K520K	EPHB1_ENST00000493838.1_Silent_p.K81K	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	520	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TCAGTGGCAAGATGTGCTTCC	0.567													24	51					0	0	1	0	0	A	134880997	G	A	134880997	2	1	48	1	0	0	0	0	0	0	0	1	5202	933	33	3		3	EPHB1	3	134880997	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1214768	134880997	63141433	1043	5437										
PPP2R3A	5523	broad.mit.edu	37	chr3	135722020	135722020	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgagcctaaatctaaagtCtcttcacccatagaaaaagt	5	10	3	2	rs144470120		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:135722020C>A	ENST00000264977.3	+	2	2297	c.1680C>A	c.(1678-1680)gtC>gtA	p.V560V	PPP2R3A_ENST00000490467.1_Intron	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	560					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AATCTAAAGTCTCTTCACCCA	0.408													21	40					1.96292e-10	2.40731e-10	1	1	0	A	135722020	C	A	135722020	2	1	48	1	0	0	0	0	0	0	0	1	12436	900	32	2		2	PPP2R3A	3	135722020	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	841023	135722020	62300410	1044	5438										
STAG1	10274	broad.mit.edu	37	chr3	136096557	136096557	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgctggcaaacagccaaaAaggatttcaccgttttcctc	7	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:136096557A>C	ENST00000383202.2	-	23	2571	c.2315T>G	c.(2314-2316)tTt>tGt	p.F772C	STAG1_ENST00000236698.5_Missense_Mutation_p.F772C|STAG1_ENST00000434713.2_Missense_Mutation_p.F546C|STAG1_ENST00000536929.1_Missense_Mutation_p.F356C	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	772					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						AACAGCCAAAAAGGATTTCAC	0.368													18	23					0	0	1	0	0	C	136096557	A	C	136096557	3	2	48	1	0	0	0	0	1	0	0	0	15297	14	1	4	1509	4	STAG1	3	136096557	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	374537	136096557	61925873	1045	5439										
STAG1	10274	broad.mit.edu	37	chr3	136221539	136221539	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaatcattttatttctctcGgcttcatattgtctctgggt	6	10	4	0	rs113504457	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:136221539G>A	ENST00000383202.2	-	8	1015	c.759C>T	c.(757-759)gcC>gcT	p.A253A	STAG1_ENST00000236698.5_Silent_p.A253A|STAG1_ENST00000434713.2_Silent_p.A27A	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	253					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding	p.A253A(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TATTTCTCTCGGCTTCATATT	0.383													6	50					0	0	1	0	0	A	136221539	G	A	136221539	2	1	48	1	0	0	0	0	0	0	0	1	15297	1103	39	1		1	STAG1	3	136221539	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	124982	136221539	61800891	1046	5440										
A4GNT	51146	broad.mit.edu	37	chr3	137843320	137843320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcccacacttcatagtagCgcctccactctcgataggag	7	14	2	0	rs142237741		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:137843320C>T	ENST00000236709.3	-	3	1010	c.809G>A	c.(808-810)cGc>cAc	p.R270H		NM_016161.2	NP_057245.1	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	270					protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity	p.R270H(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)	16						TTCATAGTAGCGCCTCCACTC	0.498													25	38					0	0	1	0	0	T	137843320	C	T	137843320	3	4	48	1	0	0	0	0	1	0	0	0	7	768	27	1	217	1	A4GNT	3	137843320	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1621781	137843320	60179110	1047	5441										
DBR1	51163	broad.mit.edu	37	chr3	137881390	137881390	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcaatttttccaatacttCtttcataccttcttctgttg	2	10	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:137881390C>A	ENST00000260803.4	-	8	1129	c.976G>T	c.(976-978)Gaa>Taa	p.E326*	DBR1_ENST00000505015.2_Nonsense_Mutation_p.E92*	NM_016216.3	NP_057300.2	Q9UK59	DBR1_HUMAN	debranching RNA lariats 1	326						nucleus	metal ion binding|RNA lariat debranching enzyme activity			NS(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						TCCAATACTTCTTTCATACCT	0.333													21	46					1.87028e-06	2.10206e-06	1	1	0	A	137881390	C	A	137881390	4	1	48	1	0	0	0	0	0	1	0	0	4281	922	32	2	662	2	DBR1	3	137881390	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	38070	137881390	60141040	1048	5442										
CLSTN2	64084	broad.mit.edu	37	chr3	140123599	140123599	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagatgtgccttttgccatcGacagaaatggtgagtgacct	11	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:140123599G>A	ENST00000458420.3	+	4	818	c.628G>A	c.(628-630)Gac>Aac	p.D210N		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	210	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TTTTGCCATCGACAGAAATGG	0.527										HNSCC(16;0.037)			17	73					0	0	1	0	0	A	140123599	G	A	140123599	3	1	48	1	0	0	0	0	1	0	0	0	3585	1058	37	1	642	1	CLSTN2	3	140123599	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2242209	140123599	57898831	1049	5443										
CLSTN2	64084	broad.mit.edu	37	chr3	140281660	140281660	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcttggcacaggtgtgggCtccatgagccgctatgagca	13	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:140281660C>A	ENST00000458420.3	+	14	2410	c.2220C>A	c.(2218-2220)ggC>ggA	p.G740G		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	740					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CAGGTGTGGGCTCCATGAGCC	0.567										HNSCC(16;0.037)			20	45					3.51602e-12	4.42195e-12	1	1	0	A	140281660	C	A	140281660	2	1	48	1	0	0	0	0	0	0	0	1	3585	784	28	5		5	CLSTN2	3	140281660	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	158061	140281660	57740770	1050	5444										
ZBTB38	253461	broad.mit.edu	37	chr3	141162802	141162802	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcattttctgtcttgaaacTttcatgacctactatatact	4	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:141162802T>G	ENST00000514251.1	+	4	1851	c.1572T>G	c.(1570-1572)acT>acG	p.T524T	ZBTB38_ENST00000441582.2_Silent_p.T524T|ZBTB38_ENST00000321464.5_Silent_p.T525T			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	524					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						GTCTTGAAACTTTCATGACCT	0.383													25	38					0	0	1	0	0	G	141162802	T	G	141162802	2	3	48	1	0	0	0	0	0	0	0	1	17597	1596	56	4		4	ZBTB38	3	141162802	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	881142	141162802	56859628	1051	5445										
ZBTB38	253461	broad.mit.edu	37	chr3	141163404	141163404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acacagcagccagttttcatCggtgatcatgcacagcaatg	9	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:141163404C>T	ENST00000514251.1	+	4	2453	c.2174C>T	c.(2173-2175)tCg>tTg	p.S725L	ZBTB38_ENST00000441582.2_Missense_Mutation_p.S725L|ZBTB38_ENST00000321464.5_Missense_Mutation_p.S726L			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	725					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						CAGTTTTCATCGGTGATCATG	0.502													20	61					0	0	1	0	0	T	141163404	C	T	141163404	3	4	48	1	0	0	0	0	1	0	0	0	17597	893	31	1	2176	1	ZBTB38	3	141163404	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	602	141163404	56859026	1052	5446										
ATP1B3	483	broad.mit.edu	37	chr3	141644523	141644523	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgggacgagttatgttcAaaatcacagcacgtgcatag	10	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:141644523A>C	ENST00000286371.3	+	7	1008	c.820A>C	c.(820-822)Aaa>Caa	p.K274Q	ATP1B3_ENST00000539728.1_3'UTR|ATP1B3_ENST00000484727.1_3'UTR|ATP1B3_ENST00000462082.1_Missense_Mutation_p.K84Q	NM_001679.2	NP_001670.1	P54709	AT1B3_HUMAN	ATPase, Na+/K+ transporting, beta 3 polypeptide	274					ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			cervix(1)|endometrium(1)|lung(2)	4						AGTTATGTTCAAAATCACAGC	0.403													49	110					0	0	1	0	0	C	141644523	A	C	141644523	3	2	48	1	0	0	0	0	1	0	0	0	1133	131	5	4	846	4	ATP1B3	3	141644523	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	481119	141644523	56377907	1053	5447										
ATR	545	broad.mit.edu	37	chr3	142178199	142178199	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttggtagcatacactggcGaagttcttttcctgtcatat	8	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142178199G>A	ENST00000350721.4	-	43	7340	c.7219C>T	c.(7219-7221)Cgc>Tgc	p.R2407C	ATR_ENST00000383101.3_Missense_Mutation_p.R2343C	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2407	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						ATACACTGGCGAAGTTCTTTT	0.383								Other conserved DNA damage response genes					16	28					0	0	1	0	0	A	142178199	G	A	142178199	3	1	48	1	0	0	0	0	1	0	0	0	1202	1058	37	1	735	1	ATR	3	142178199	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	533676	142178199	55844231	1054	5448										
ATR	545	broad.mit.edu	37	chr3	142278191	142278191	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaacaaacttctacagctcTtaagcacttttgtgtaaaaa	4	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142278191T>G	ENST00000350721.4	-	7	1755	c.1634A>C	c.(1633-1635)aAg>aCg	p.K545T	ATR_ENST00000383101.3_Missense_Mutation_p.K481T	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	545					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TCTACAGCTCTTAAGCACTTT	0.373								Other conserved DNA damage response genes					13	28					0	0	1	0	0	G	142278191	T	G	142278191	3	3	48	1	0	0	0	0	1	0	0	0	1202	1609	56	4	6464	4	ATR	3	142278191	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	99992	142278191	55744239	1055	5449										
ATR	545	broad.mit.edu	37	chr3	142281126	142281126	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagagctttacaaatatttCtcacatagaccttcctgact	4	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142281126C>A	ENST00000350721.4	-	4	1239	c.1118G>T	c.(1117-1119)aGa>aTa	p.R373I	ATR_ENST00000383101.3_Missense_Mutation_p.R373I	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	373					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						ACAAATATTTCTCACATAGAC	0.358								Other conserved DNA damage response genes					21	46					5.26018e-13	6.70247e-13	1	1	0	A	142281126	C	A	142281126	3	1	48	1	0	0	0	0	1	0	0	0	1202	913	32	2	6992	2	ATR	3	142281126	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2935	142281126	55741304	1056	5450										
ATR	545	broad.mit.edu	37	chr3	142281164	142281164	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttgtaaagcagattcataCccagctggcacaaatttaag	7	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142281164C>T	ENST00000350721.4	-	4	1201	c.1080G>A	c.(1078-1080)ggG>ggA	p.G360G	ATR_ENST00000383101.3_Silent_p.G360G	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	360					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						CAGATTCATACCCAGCTGGCA	0.398								Other conserved DNA damage response genes					22	44					0	0	1	0	0	T	142281164	C	T	142281164	2	4	48	1	0	0	0	0	0	0	0	1	1202	494	18	3		3	ATR	3	142281164	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	38	142281164	55741266	1057	5451										
PLS1	5357	broad.mit.edu	37	chr3	142395077	142395077	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtaagcatcttatacccaTgaatcccaatgatgatagtc	6	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142395077T>C	ENST00000337777.3	+	5	656	c.443T>C	c.(442-444)aTg>aCg	p.M148T	PLS1_ENST00000457734.2_Missense_Mutation_p.M148T|PLS1_ENST00000497002.1_Missense_Mutation_p.M148T	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	148	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						CTTATACCCATGAATCCCAAT	0.413													34	79					0	0	1	0	0	C	142395077	T	C	142395077	3	2	48	1	0	0	0	0	1	0	0	0	12154	1464	51	4	457	4	PLS1	3	142395077	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	113913	142395077	55627353	1058	5452										
TRPC1	7220	broad.mit.edu	37	chr3	142503722	142503722	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatctcagtttggcagaatCattcacacaccttttatgaa	5	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142503722C>A	ENST00000273482.6	+	6	1426	c.1035C>A	c.(1033-1035)atC>atA	p.I345I	TRPC1_ENST00000476941.1_Silent_p.I379I	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	379					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						TTGGCAGAATCATTCACACAC	0.358													4	27					0.150653	0.151842	1	1	0	A	142503722	C	A	142503722	2	1	48	1	0	0	0	0	0	0	0	1	16638	816	29	2		2	TRPC1	3	142503722	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	108645	142503722	55518708	1059	5453										
PCOLCE2	26577	broad.mit.edu	37	chr3	142548671	142548671	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgaataagaagttcatttCtctcagacacaattggccta	6	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:142548671C>A	ENST00000295992.3	-	6	1034	c.728G>T	c.(727-729)aGa>aTa	p.R243I	PCOLCE2_ENST00000485766.1_Intron	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	243	CUB 2.					extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						AAGTTCATTTCTCTCAGACAC	0.303													29	37					1.2476e-16	1.66396e-16	1	1	0	A	142548671	C	A	142548671	3	1	48	1	0	0	0	0	1	0	0	0	11641	913	32	2	535	2	PCOLCE2	3	142548671	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	44949	142548671	55473759	1060	5454										
SLC9A9	285195	broad.mit.edu	37	chr3	143082376	143082376	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccgagcactctctgctttCgtcatgtttttatccaagtt	7	11	2	0	rs141051651	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:143082376C>T	ENST00000316549.6	-	14	1762	c.1554G>A	c.(1552-1554)acG>acA	p.T518T		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	518					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TCTCTGCTTTCGTCATGTTTT	0.368													20	42					0	0	1	0	0	T	143082376	C	T	143082376	2	4	48	1	0	0	0	0	0	0	0	1	14775	871	31	1		1	SLC9A9	3	143082376	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	533705	143082376	54940054	1061	5455										
CPA3	1359	broad.mit.edu	37	chr3	148583119	148583119	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctcatcctgcctgtgggtTtgattgctaccactcttgca	10	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:148583119T>G	ENST00000296046.3	+	1	77	c.25T>G	c.(25-27)Ttg>Gtg	p.L9V	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	9					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GCCTGTGGGTTTGATTGCTAC	0.468													15	54					0	0	1	0	0	G	148583119	T	G	148583119	3	3	48	1	0	0	0	0	1	0	0	0	3814	1838	64	4	27	4	CPA3	3	148583119	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5500743	148583119	49439311	1062	5456										
HLTF	6596	broad.mit.edu	37	chr3	148756968	148756968	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaattgattcaactcttttCttttgggccatggaaccatc	7	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:148756968C>A	ENST00000310053.5	-	23	2857	c.2664G>T	c.(2662-2664)aaG>aaT	p.K888N	HLTF_ENST00000494055.1_Missense_Mutation_p.K888N|HLTF_ENST00000392912.2_Missense_Mutation_p.K888N|HLTF_ENST00000465259.1_Missense_Mutation_p.K887N	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	888	Helicase C-terminal.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CAACTCTTTTCTTTTGGGCCA	0.373													7	17					0.0381472	0.0387537	1	1	0	A	148756968	C	A	148756968	3	1	48	1	0	0	0	0	1	0	0	0	7255	912	32	2	377	2	HLTF	3	148756968	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	173849	148756968	49265462	1063	5457										
HLTF	6596	broad.mit.edu	37	chr3	148768120	148768120	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaccataataaacataaaAattcaagtgtacatctgatt	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:148768120A>C	ENST00000310053.5	-	15	1709	c.1516T>G	c.(1516-1518)Ttt>Gtt	p.F506V	HLTF_ENST00000494055.1_Missense_Mutation_p.F506V|HLTF_ENST00000392912.2_Missense_Mutation_p.F506V|HLTF_ENST00000465259.1_Missense_Mutation_p.F505V	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	506	Helicase ATP-binding.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TAAACATAAAAATTCAAGTGT	0.303													16	32					0	0	1	0	0	C	148768120	A	C	148768120	3	2	48	1	0	0	0	0	1	0	0	0	7255	14	1	4	1557	4	HLTF	3	148768120	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	11152	148768120	49254310	1064	5458										
PFN2	5217	broad.mit.edu	37	chr3	149686293	149686293	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtcaaaccgttggtaaaGaaaccttcccggtcttttcc	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:149686293G>T	ENST00000239940.7	-	2	429	c.177C>A	c.(175-177)ttC>ttA	p.F59L	PFN2_ENST00000423691.2_Missense_Mutation_p.F59L|PFN2_ENST00000498307.1_Missense_Mutation_p.F10L|PFN2_ENST00000497148.1_Missense_Mutation_p.F10L|PFN2_ENST00000494827.1_Missense_Mutation_p.F10L|PFN2_ENST00000490975.1_Missense_Mutation_p.F59L|PFN2_ENST00000489155.1_Missense_Mutation_p.F10L|PFN2_ENST00000461930.1_3'UTR|PFN2_ENST00000481767.1_Missense_Mutation_p.F10L|PFN2_ENST00000481275.1_Missense_Mutation_p.F10L|PFN2_ENST00000475518.1_Missense_Mutation_p.F10L|PFN2_ENST00000461868.1_Missense_Mutation_p.F59L|PFN2_ENST00000452853.2_Missense_Mutation_p.F59L			P35080	PROF2_HUMAN	profilin 2	59					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CGTTGGTAAAGAAACCTTCCC	0.418													10	159					1.58986e-06	1.78832e-06	1	1	0	T	149686293	G	T	149686293	3	4	48	1	0	0	0	0	1	0	0	0	11815	933	33	2	355	2	PFN2	3	149686293	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	918173	149686293	48336137	1065	5459										
IGSF10	285313	broad.mit.edu	37	chr3	151162927	151162927	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtcactcttctttgtgttCttctgtccatcccaatctga	5	12	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:151162927C>A	ENST00000282466.3	-	4	4841	c.4842G>T	c.(4840-4842)aaG>aaT	p.K1614N		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1614					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTTTGTGTTCTTCTGTCCAT	0.418													33	52					1.99505e-19	2.71627e-19	1	1	0	A	151162927	C	A	151162927	3	1	48	1	0	0	0	0	1	0	0	0	7640	912	32	2	3089	2	IGSF10	3	151162927	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1476634	151162927	46859503	1066	5460										
IGSF10	285313	broad.mit.edu	37	chr3	151165867	151165867	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttggtctttcggggtgacCtgtaatattcttaatgtgcc	10	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:151165867C>A	ENST00000282466.3	-	4	1901	c.1902G>T	c.(1900-1902)caG>caT	p.Q634H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	634	Ig-like C2-type 2.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCGGGGTGACCTGTAATATTC	0.408													18	51					6.94344e-10	8.4399e-10	1	1	0	A	151165867	C	A	151165867	3	1	48	1	0	0	0	0	1	0	0	0	7640	680	24	5	6029	5	IGSF10	3	151165867	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2940	151165867	46856563	1067	5461										
AADACL2	344752	broad.mit.edu	37	chr3	151463410	151463410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatggagtggatcccacccGaatctgcattgcgggagaca	12	10	1	1	rs35364301		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:151463410G>A	ENST00000356517.3	+	4	654	c.545G>A	c.(544-546)cGa>cAa	p.R182Q		NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	182						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GATCCCACCCGAATCTGCATT	0.423													19	81					0	0	1	0	0	A	151463410	G	A	151463410	3	1	48	1	0	0	0	0	1	0	0	0	11	1058	37	1	559	1	AADACL2	3	151463410	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	297543	151463410	46559020	1068	5462										
AADAC	13	broad.mit.edu	37	chr3	151545599	151545599	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaagtcatctcttcaaatTtgttaattggagttccctgc	6	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:151545599T>C	ENST00000232892.6	+	5	965	c.839T>C	c.(838-840)tTt>tCt	p.F280S	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	280					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTCTTCAAATTTGTTAATTGG	0.383													5	60					0	0	1	0	0	C	151545599	T	C	151545599	3	2	48	1	0	0	0	0	1	0	0	0	10	1841	64	4	857	4	AADAC	3	151545599	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	82189	151545599	46476831	1069	5463										
MBNL1	4154	broad.mit.edu	37	chr3	152174096	152174096	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgccagccactgtgtccgcAgcaacaacatctgccacaag	8	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:152174096A>G	ENST00000324196.5	+	5	1637	c.848A>G	c.(847-849)cAg>cGg	p.Q283R	MBNL1_ENST00000324210.5_Silent_p.A346A|MBNL1_ENST00000282488.7_Silent_p.A266A|MBNL1_ENST00000492948.1_Intron|MBNL1_ENST00000463374.1_Silent_p.A352A|MBNL1_ENST00000545754.1_Silent_p.A278A|MBNL1_ENST00000357472.3_Intron|MBNL1_ENST00000485910.1_Silent_p.A266A|MBNL1_ENST00000493459.1_Silent_p.A307A|MBNL1_ENST00000282486.6_Silent_p.A352A|MBNL1_ENST00000355460.2_Silent_p.A334A|MBNL1_ENST00000485509.1_Missense_Mutation_p.Q283R|MBNL1_ENST00000498502.1_Intron	NM_207296.1	NP_997179.1	Q9NR56	MBNL1_HUMAN	muscleblind-like splicing regulator 1	291					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTGTGTCCGCAGCAACAACAT	0.458													86	151					0	0	1	0	0	G	152174096	A	G	152174096	3	3	48	1	0	0	0	0	1	0	0	0	9402	188	7	4	1122	4	MBNL1	3	152174096	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	628497	152174096	45848334	1070	5464										
DHX36	170506	broad.mit.edu	37	chr3	154018402	154018402	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcttcttccaaaacaatgTatcggatgagggcaacaatc	7	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:154018402T>G	ENST00000496811.1	-	11	1522	c.1442A>C	c.(1441-1443)tAc>tCc	p.Y481S	DHX36_ENST00000544526.1_Missense_Mutation_p.Y481S|DHX36_ENST00000329463.5_Missense_Mutation_p.Y481S|DHX36_ENST00000308361.6_Missense_Mutation_p.Y481S	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	481	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CAAAACAATGTATCGGATGAG	0.299													13	24					0	0	1	0	0	G	154018402	T	G	154018402	3	3	48	1	0	0	0	0	1	0	0	0	4537	1638	57	4	1644	4	DHX36	3	154018402	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1844306	154018402	44004028	1071	5465										
DHX36	170506	broad.mit.edu	37	chr3	154018782	154018782	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaataaacttaccttcttCgcagttcccttacataatct	2	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:154018782C>T	ENST00000496811.1	-	10	1432	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	DHX36_ENST00000544526.1_Missense_Mutation_p.R451Q|DHX36_ENST00000329463.5_Missense_Mutation_p.R451Q|DHX36_ENST00000308361.6_Missense_Mutation_p.R451Q	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	451						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTACCTTCTTCGCAGTTCCCT	0.373													36	61					0	0	1	0	0	T	154018782	C	T	154018782	3	4	48	1	0	0	0	0	1	0	0	0	4537	884	31	1	1738	1	DHX36	3	154018782	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	380	154018782	44003648	1072	5466										
GPR149	344758	broad.mit.edu	37	chr3	154146951	154146951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacacggtcagcaccacgcCgagcacctggcccgatcttc	9	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:154146951C>T	ENST00000389740.2	-	1	553	c.454G>A	c.(454-456)Ggc>Agc	p.G152S		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	152						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AGCACCACGCCGAGCACCTGG	0.637													25	48					0	0	1	0	0	T	154146951	C	T	154146951	3	4	48	1	0	0	0	0	1	0	0	0	6693	652	23	1	1757	1	GPR149	3	154146951	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	128169	154146951	43875479	1073	5467										
PLCH1	23007	broad.mit.edu	37	chr3	155199563	155199563	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatactttgagttttgacatCttgaatattgttgaatattt	6	3	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:155199563C>A	ENST00000460012.1	-	23	4519	c.4162G>T	c.(4162-4164)Gat>Tat	p.D1388Y	PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000414191.1_Missense_Mutation_p.D1388Y|PLCH1_ENST00000340059.7_Missense_Mutation_p.D1426Y|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000334686.6_Missense_Mutation_p.D1388Y			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1426					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GTTTTGACATCTTGAATATTG	0.408													27	51					1.04121e-07	1.21041e-07	1	1	0	A	155199563	C	A	155199563	3	1	48	1	0	0	0	0	1	0	0	0	12084	913	32	2	809	2	PLCH1	3	155199563	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1052612	155199563	42822867	1074	5468										
GMPS	8833	broad.mit.edu	37	chr3	155611439	155611439	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactgttcgtgcagtctgaaAttttccccttggaaacacca	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:155611439A>C	ENST00000496455.1	+	2	495	c.160A>C	c.(160-162)Att>Ctt	p.I54L	GMPS_ENST00000295920.7_Intron	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	54	Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCAGTCTGAAATTTTCCCCTT	0.443			T	MLL	AML								13	20					0	0	1	0	0	C	155611439	A	C	155611439	3	2	48	1	0	0	0	0	1	0	0	0	6539	101	4	4	166	4	GMPS	3	155611439	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	411876	155611439	42410991	1075	5469										
GMPS	8833	broad.mit.edu	37	chr3	155652731	155652731	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatatatttggcccaccagTtaaagaacctcctacagatg	6	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:155652731T>C	ENST00000496455.1	+	14	2038	c.1703T>C	c.(1702-1704)gTt>gCt	p.V568A	GMPS_ENST00000295920.7_Missense_Mutation_p.V469A	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	568					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGCCCACCAGTTAAAGAACCT	0.378			T	MLL	AML								19	52					0	0	1	0	0	C	155652731	T	C	155652731	3	2	48	1	0	0	0	0	1	0	0	0	6539	1725	60	4	1757	4	GMPS	3	155652731	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	41292	155652731	42369699	1076	5470										
KCNAB1	7881	broad.mit.edu	37	chr3	156232899	156232899	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctccctaggaagcctattCtgtagcaagacagttcaata	7	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:156232899C>T	ENST00000302490.8	+	10	1572	c.701C>T	c.(700-702)tCt>tTt	p.S234F	KCNAB1_ENST00000389636.5_Missense_Mutation_p.S223F|KCNAB1_ENST00000389634.5_Missense_Mutation_p.S205F|KCNAB1_ENST00000497291.1_3'UTR|KCNAB1_ENST00000471742.1_Missense_Mutation_p.S241F|KCNAB1_ENST00000490337.1_Missense_Mutation_p.S252F	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	252						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GAAGCCTATTCTGTAGCAAGA	0.423													14	49					0	0	1	0	0	T	156232899	C	T	156232899	3	4	48	1	0	0	0	0	1	0	0	0	8052	913	32	3	1264	3	KCNAB1	3	156232899	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	580168	156232899	41789531	1077	5471										
VEPH1	79674	broad.mit.edu	37	chr3	157177906	157177906	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcccacaaaccataaatgCttgatgaaaatacttttaaa	3	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:157177906C>A	ENST00000494677.1	-	5	1115	c.593G>T	c.(592-594)aGc>aTc	p.S198I	VEPH1_ENST00000543418.1_Intron|VEPH1_ENST00000537559.1_Intron|VEPH1_ENST00000468233.1_Missense_Mutation_p.S198I|VEPH1_ENST00000362010.2_Intron|VEPH1_ENST00000392832.2_Intron|VEPH1_ENST00000392833.2_Intron	NM_001167915.1	NP_001161387.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	0						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ACCATAAATGCTTGATGAAAA	0.378													13	41					7.03913e-09	8.36985e-09	1	1	0	A	157177906	C	A	157177906	3	1	48	1	0	0	0	0	1	0	0	0	17213	797	28	5	2074	5	VEPH1	3	157177906	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	945007	157177906	40844524	1078	5472										
VEPH1	79674	broad.mit.edu	37	chr3	157178088	157178088	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttccttgttgcctctgtgGaggaatttcactgcaatggg	12	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:157178088G>A	ENST00000362010.2	-	4	718	c.411C>T	c.(409-411)ctC>ctT	p.L137L	VEPH1_ENST00000543418.1_Silent_p.L137L|VEPH1_ENST00000537559.1_Silent_p.L137L|VEPH1_ENST00000468233.1_Silent_p.L137L|VEPH1_ENST00000494677.1_Silent_p.L137L|VEPH1_ENST00000392832.2_Silent_p.L137L|VEPH1_ENST00000392833.2_Silent_p.L137L	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	137						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TGCCTCTGTGGAGGAATTTCA	0.443													26	57					0	0	1	0	0	A	157178088	G	A	157178088	2	1	48	1	0	0	0	0	0	0	0	1	17213	1161	41	3		3	VEPH1	3	157178088	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	182	157178088	40844342	1079	5473										
IL12A	3592	broad.mit.edu	37	chr3	159708090	159708090	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagggccgtcagcaacatGctccagaaggtgagcctttc	12	12	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:159708090G>T	ENST00000305579.2	+	2	562	c.255G>T	c.(253-255)atG>atT	p.M85I	IL12A_ENST00000466512.1_Missense_Mutation_p.M85I|CTD-2049J23.2_ENST00000497452.1_RNA|IL12A_ENST00000480787.1_Missense_Mutation_p.M85I	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	51					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TCAGCAACATGCTCCAGAAGG	0.592													31	53					1.45844e-13	1.87318e-13	1	1	0	T	159708090	G	T	159708090	3	4	48	1	0	0	0	0	1	0	0	0	7667	1319	46	5	261	5	IL12A	3	159708090	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2530002	159708090	38314340	1080	5474										
SMC4	10051	broad.mit.edu	37	chr3	160120524	160120524	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaatgttattgattctatgCtttttgtgtttggctatcga	8	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:160120524C>A	ENST00000357388.3	+	4	830	c.379C>A	c.(379-381)Ctt>Att	p.L127I	SMC4_ENST00000360111.2_Missense_Mutation_p.L127I|RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000462787.1_Missense_Mutation_p.L127I|SMC4_ENST00000469762.1_Missense_Mutation_p.L102I|SMC4_ENST00000344722.5_Missense_Mutation_p.L127I	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	127					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGATTCTATGCTTTTTGTGTT	0.338													24	45					1.10923e-09	1.34134e-09	1	1	0	A	160120524	C	A	160120524	3	1	48	1	0	0	0	0	1	0	0	0	14838	797	28	5	389	5	SMC4	3	160120524	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	412434	160120524	37901906	1081	5475										
SMC4	10051	broad.mit.edu	37	chr3	160150975	160150975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttgattttaaaaatgtgtCcattgttgcattttatatat	5	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:160150975C>T	ENST00000357388.3	+	23	4143	c.3692C>T	c.(3691-3693)tCc>tTc	p.S1231F	SMC4_ENST00000360111.2_Missense_Mutation_p.S1173F|RP11-432B6.3_ENST00000483754.1_Intron|TRIM59_ENST00000543469.1_3'UTR|SMC4_ENST00000462787.1_Missense_Mutation_p.S1173F|SMC4_ENST00000469762.1_Missense_Mutation_p.S1206F|SMC4_ENST00000344722.5_Missense_Mutation_p.S1231F	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	1231					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAAAATGTGTCCATTGTTGCA	0.343													27	33					0	0	1	0	0	T	160150975	C	T	160150975	3	4	48	1	0	0	0	0	1	0	0	0	14838	855	30	3	3778	3	SMC4	3	160150975	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30451	160150975	37871455	1082	5476										
ARL14	80117	broad.mit.edu	37	chr3	160395267	160395267	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atattaccaccatccctacaAtaggtttcaatgtggaaatg	6	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:160395267A>C	ENST00000320767.2	+	1	320	c.133A>C	c.(133-135)Ata>Cta	p.I45L		NM_025047.2	NP_079323.1	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	45					small GTPase mediated signal transduction	intracellular	GTP binding			lung(6)	6			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			CATCCCTACAATAGGTTTCAA	0.413													24	50					0	0	1	0	0	C	160395267	A	C	160395267	3	2	48	1	0	0	0	0	1	0	0	0	927	101	4	4	135	4	ARL14	3	160395267	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	244292	160395267	37627163	1083	5477										
PPM1L	151742	broad.mit.edu	37	chr3	160786805	160786805	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagcaatgaagaagcagttCgattcatcaaggagcgcttg	11	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:160786805C>T	ENST00000498165.1	+	4	1044	c.943C>T	c.(943-945)Cga>Tga	p.R315*	PPM1L_ENST00000295839.9_Nonsense_Mutation_p.R188*|PPM1L_ENST00000480117.1_3'UTR|PPM1L_ENST00000464260.1_Nonsense_Mutation_p.R136*	NM_139245.2	NP_640338.2	Q5SGD2	PPM1L_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1L	315	PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity	p.R315*(2)|p.R136*(2)		breast(1)|endometrium(1)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AGAAGCAGTTCGATTCATCAA	0.473													23	48					0	0	1	0	0	T	160786805	C	T	160786805	4	4	48	1	0	0	0	0	0	1	0	0	12392	876	31	1	957	1	PPM1L	3	160786805	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	391538	160786805	37235625	1084	5478										
B3GALNT1	8706	broad.mit.edu	37	chr3	160804162	160804162	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaaggacaatgccaacatTttgtcttccttttcagcctc	5	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:160804162T>C	ENST00000392781.2	-	8	1128	c.381A>G	c.(379-381)aaA>aaG	p.K127K	B3GALNT1_ENST00000392780.1_Silent_p.K127K|B3GALNT1_ENST00000417187.1_Intron|B3GALNT1_ENST00000488170.1_Silent_p.K127K|B3GALNT1_ENST00000320474.4_Silent_p.K127K|B3GALNT1_ENST00000392779.2_Silent_p.K127K|B3GALNT1_ENST00000473285.1_Silent_p.K127K	NM_001038628.1	NP_001033717.1	O75752	B3GL1_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	127					protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			ATGCCAACATTTTGTCTTCCT	0.383													23	44					0	0	1	0	0	C	160804162	T	C	160804162	2	2	48	1	0	0	0	0	0	0	0	1	1243	1838	64	4		4	B3GALNT1	3	160804162	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	17357	160804162	37218268	1085	5479										
NMD3	51068	broad.mit.edu	37	chr3	160952642	160952642	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgattcaagtgaggcaaaAggtaatgagagaagatgatg	14	2	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:160952642A>G	ENST00000460469.1	+	5	940	c.486_splice	c.e5+1	p.K162_splice	NMD3_ENST00000472947.1_Splice_Site_p.K162_splice|NMD3_ENST00000478160.1_3'UTR|NMD3_ENST00000351193.2_Splice_Site_p.K162_splice			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	162					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			GTGAGGCAAAAGGTAATGAGA	0.398													28	70					0	0	1	0	0	G	160952642	A	G	160952642	5	3	48	1	0	0	0	0	0	0	1	0	10534	86	3	4	503	4	NMD3	3	160952642	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	148480	160952642	37069788	1086	5480										
SI	6476	broad.mit.edu	37	chr3	164725732	164725732	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggataatttagttcgtcatTtctgcattgattagtagttg	9	4	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:164725732T>G	ENST00000264382.3	-	36	4296	c.4234A>C	c.(4234-4236)Aat>Cat	p.N1412H		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1412	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGTTCGTCATTTCTGCATTGA	0.259										HNSCC(35;0.089)			12	33					0	0	1	0	0	G	164725732	T	G	164725732	3	3	48	1	0	0	0	0	1	0	0	0	14351	1841	64	4	1301	4	SI	3	164725732	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3773090	164725732	33296698	1087	5481										
SI	6476	broad.mit.edu	37	chr3	164737404	164737404	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctacaccagggggttggtCtcttgtgaacattccccaag	10	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:164737404C>T	ENST00000264382.3	-	28	3471	c.3409G>A	c.(3409-3411)Gac>Aac	p.D1137N		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1137	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGGGGTTGGTCTCTTGTGAAC	0.463										HNSCC(35;0.089)			17	42					0	0	1	0	0	T	164737404	C	T	164737404	3	4	48	1	0	0	0	0	1	0	0	0	14351	913	32	3	2158	3	SI	3	164737404	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11672	164737404	33285026	1088	5482										
SI	6476	broad.mit.edu	37	chr3	164739053	164739053	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctccgtcgaatctggatgCcaaaaggattttccttgatt	8	9	2	1	rs121912616	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:164739053C>A	ENST00000264382.3	-	27	3280	c.3218G>T	c.(3217-3219)gGc>gTc	p.G1073V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1073	Sucrase.		G -> D (in CSID).		carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATCTGGATGCCAAAAGGATT	0.343										HNSCC(35;0.089)			34	63					8.88839e-20	1.21309e-19	1	1	0	A	164739053	C	A	164739053	3	1	48	1	0	0	0	0	1	0	0	0	14351	739	26	5	2353	5	SI	3	164739053	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1649	164739053	33283377	1089	5483										
SI	6476	broad.mit.edu	37	chr3	164793787	164793787	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatttccaatccactaaatTtctttcttgccatctaaaaa	2	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:164793787T>G	ENST00000264382.3	-	2	76	c.14A>C	c.(13-15)aAa>aCa	p.K5T		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	5					carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCACTAAATTTCTTTCTTGC	0.269										HNSCC(35;0.089)			23	23					0	0	1	0	0	G	164793787	T	G	164793787	3	3	48	1	0	0	0	0	1	0	0	0	14351	1841	64	4	5657	4	SI	3	164793787	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	54734	164793787	33228643	1090	5484										
SLITRK3	22865	broad.mit.edu	37	chr3	164907717	164907717	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggccatgcattctccttaCttgatgacgaatgtggaatt	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:164907717C>A	ENST00000475390.1	-	2	1345	c.902G>T	c.(901-903)aGt>aTt	p.S301I	SLITRK3_ENST00000241274.3_Missense_Mutation_p.S301I			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	301						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						ATTCTCCTTACTTGATGACGA	0.438										HNSCC(40;0.11)			37	65					3.6622e-26	5.17531e-26	1	1	0	A	164907717	C	A	164907717	3	1	48	1	0	0	0	0	1	0	0	0	14797	565	20	5	2035	5	SLITRK3	3	164907717	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	113930	164907717	33114713	1091	5485										
BCHE	590	broad.mit.edu	37	chr3	165547360	165547360	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatctactcaaaatttcctCggcttttgtgtaattatctc	6	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:165547360C>T	ENST00000264381.3	-	2	1628	c.1462G>A	c.(1462-1464)Gag>Aag	p.E488K	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	488			E -> K (in BChE deficiency).		choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAAATTTCCTCGGCTTTTGTG	0.403													27	43					0	0	1	0	0	T	165547360	C	T	165547360	3	4	48	1	0	0	0	0	1	0	0	0	1356	893	31	1	358	1	BCHE	3	165547360	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	639643	165547360	32475070	1092	5486										
ZBBX	79740	broad.mit.edu	37	chr3	166958694	166958694	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagactgaattttggtatCtcttccagaacagctgaaaa	7	8	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:166958694C>A	ENST00000392766.2	-	21	2630	c.2290G>T	c.(2290-2292)Gat>Tat	p.D764Y	ZBBX_ENST00000455345.2_Missense_Mutation_p.D803Y|ZBBX_ENST00000392767.2_Missense_Mutation_p.D764Y|ZBBX_ENST00000307529.5_Missense_Mutation_p.D803Y|ZBBX_ENST00000392764.1_Missense_Mutation_p.D735Y	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	764						intracellular	zinc ion binding	p.D803N(1)|p.D764N(1)		NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						ATTTTGGTATCTCTTCCAGAA	0.383													18	39					4.35082e-09	5.20082e-09	1	1	0	A	166958694	C	A	166958694	3	1	48	1	0	0	0	0	1	0	0	0	17575	913	32	2	116	2	ZBBX	3	166958694	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1411334	166958694	31063736	1093	5487										
ZBBX	79740	broad.mit.edu	37	chr3	167016237	167016237	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttacttctgcaggctatttCttgtaacaactaagaaacaa	5	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:167016237C>A	ENST00000392766.2	-	18	2075	c.1735G>T	c.(1735-1737)Gaa>Taa	p.E579*	ZBBX_ENST00000455345.2_Nonsense_Mutation_p.E579*|ZBBX_ENST00000392767.2_Nonsense_Mutation_p.E579*|ZBBX_ENST00000307529.5_Nonsense_Mutation_p.E579*|ZBBX_ENST00000392764.1_Nonsense_Mutation_p.E550*	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	579						intracellular	zinc ion binding	p.Q578fs*1(2)		NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CAGGCTATTTCTTGTAACAAC	0.289													20	47					5.26018e-13	6.70247e-13	1	1	0	A	167016237	C	A	167016237	4	1	48	1	0	0	0	0	0	1	0	0	17575	922	32	2	683	2	ZBBX	3	167016237	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	57543	167016237	31006193	1094	5488										
SERPINI2	5276	broad.mit.edu	37	chr3	167185068	167185068	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacttcagtacaaaaaattCttcccctagaaaataatttt	3	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:167185068C>A	ENST00000476257.1	-	4	551	c.253G>T	c.(253-255)Gaa>Taa	p.E85*	SERPINI2_ENST00000264677.4_Nonsense_Mutation_p.E85*|SERPINI2_ENST00000471111.1_Nonsense_Mutation_p.E85*|SERPINI2_ENST00000461846.1_Nonsense_Mutation_p.E85*			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	85					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						ACAAAAAATTCTTCCCCTAGA	0.328													7	18					0.00198382	0.00207034	1	1	0	A	167185068	C	A	167185068	4	1	48	1	0	0	0	0	0	1	0	0	14172	922	32	2	992	2	SERPINI2	3	167185068	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	168831	167185068	30837362	1095	5489										
PDCD10	11235	broad.mit.edu	37	chr3	167414852	167414852	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccgtgaagttaacttccacGctttttttctctaaaatttt	4	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:167414852G>A	ENST00000392750.2	-	5	630	c.213C>T	c.(211-213)agC>agT	p.S71S	PDCD10_ENST00000461494.1_Silent_p.S71S|PDCD10_ENST00000497056.2_Silent_p.S71S|PDCD10_ENST00000473645.2_Silent_p.S71S|PDCD10_ENST00000492396.1_Silent_p.S8S|PDCD10_ENST00000470131.1_Silent_p.S71S|PDCD10_ENST00000487947.2_Silent_p.S71S|PDCD10_ENST00000471885.1_Silent_p.S71S	NM_007217.3	NP_009148.2	Q9BUL8	PDC10_HUMAN	programmed cell death 10	71					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			central_nervous_system(1)|kidney(1)|lung(8)|urinary_tract(2)	12						TAACTTCCACGCTTTTTTTCT	0.333													20	31					0	0	1	0	0	A	167414852	G	A	167414852	2	1	48	1	0	0	0	0	0	0	0	1	11662	1078	38	1		1	PDCD10	3	167414852	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	229784	167414852	30607578	1096	5490										
FNDC3B	64778	broad.mit.edu	37	chr3	171830294	171830294	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgtcacaatgatgatgaccGaccaaatccctctggaactg	8	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:171830294G>A	ENST00000336824.4	+	2	124	c.25G>A	c.(25-27)Gac>Aac	p.D9N	FNDC3B_ENST00000392699.1_Missense_Mutation_p.D9N|FNDC3B_ENST00000415807.2_Missense_Mutation_p.D9N|FNDC3B_ENST00000421757.1_Missense_Mutation_p.D9N|FNDC3B_ENST00000423424.1_Missense_Mutation_p.D9N|FNDC3B_ENST00000416957.1_Missense_Mutation_p.D9N	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	9						endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GATGATGACCGACCAAATCCC	0.493													17	36					0	0	1	0	0	A	171830294	G	A	171830294	3	1	48	1	0	0	0	0	1	0	0	0	6002	1058	37	1	27	1	FNDC3B	3	171830294	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4415442	171830294	26192136	1097	5491										
TBL1XR1	79718	broad.mit.edu	37	chr3	176769356	176769356	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccattttttgcagatccTtgttggctggctgcagctgc	10	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:176769356T>G	ENST00000430069.1	-	5	622	c.363A>C	c.(361-363)caA>caC	p.Q121H	TBL1XR1_ENST00000457928.2_Missense_Mutation_p.Q121H			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	121					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TTGCAGATCCTTGTTGGCTGG	0.448													30	53					0	0	1	0	0	G	176769356	T	G	176769356	3	3	48	1	0	0	0	0	1	0	0	0	15699	1606	56	4	1229	4	TBL1XR1	3	176769356	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4939062	176769356	21253074	1098	5492										
ZMAT3	64393	broad.mit.edu	37	chr3	178742906	178742906	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgccggaattccatctcttCgccagctccaacattacaca	5	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:178742906C>T	ENST00000311417.2	-	6	1510	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K	ZMAT3_ENST00000432729.1_Missense_Mutation_p.E256K	NM_022470.3	NP_071915.1	Q9HA38	ZMAT3_HUMAN	zinc finger, matrin-type 3	257					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(1)|skin(1)	14	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			TCCATCTCTTCGCCAGCTCCA	0.478													30	65					0	0	1	0	0	T	178742906	C	T	178742906	3	4	48	1	0	0	0	0	1	0	0	0	17750	893	31	1	104	1	ZMAT3	3	178742906	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1973550	178742906	19279524	1099	5493										
PIK3CA	5290	broad.mit.edu	37	chr3	178916876	178916876	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attttttgatgaaacaagacGactttgtgaccttcggcttt	8	7	0	4	rs121913287		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:178916876G>A	ENST00000263967.3	+	2	420	c.263G>A	c.(262-264)cGa>cAa	p.R88Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(53)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363	R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SKUT1_SOFT_TISSUE)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			30	46					0	0	1	0	0	A	178916876	G	A	178916876	3	1	48	1	0	0	0	0	1	0	0	0	11960	1058	37	1	265	1	PIK3CA	3	178916876	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	173970	178916876	19105554	1100	5494										
PIK3CA	5290	broad.mit.edu	37	chr3	178916936	178916936	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattgaaccagtaggcaaccGtgaagaaaagatcctcaatc	8	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:178916936G>A	ENST00000263967.3	+	2	480	c.323G>A	c.(322-324)cGt>cAt	p.R108H		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	108	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R108H(11)|p.R108L(2)|p.G106_R108delGNR(2)|p.G106_R108del(2)|p.R108P(1)|p.R108del(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTAGGCAACCGTGAAGAAAAG	0.338		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			20	41					0	0	1	0	0	A	178916936	G	A	178916936	3	1	48	1	0	0	0	0	1	0	0	0	11960	1145	40	1	325	1	PIK3CA	3	178916936	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	60	178916936	19105494	1101	5495										
KCNMB3	27094	broad.mit.edu	37	chr3	178968869	178968869	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacaaaatgaaatcccagtTcagagcttggtgaaaagtcc	8	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:178968869T>C	ENST00000314235.5	-	1	534	c.23A>G	c.(22-24)gAa>gGa	p.E8G	KCNMB3_ENST00000497599.1_Intron|KCNMB3_ENST00000392685.2_5'UTR|KCNMB3_ENST00000485523.1_Intron|KCNMB3_ENST00000349697.2_Intron	NM_014407.3	NP_055222.3	Q9NPA1	KCMB3_HUMAN	potassium large conductance calcium-activated channel, subfamily M beta member 3	8					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity			NS(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			AAATCCCAGTTCAGAGCTTGG	0.403													23	43					0	0	1	0	0	C	178968869	T	C	178968869	3	2	48	1	0	0	0	0	1	0	0	0	8119	1783	62	4	961	4	KCNMB3	3	178968869	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	51933	178968869	19053561	1102	5496										
ZNF639	51193	broad.mit.edu	37	chr3	179051980	179051980	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtttgtgatgactgtgggAaaggcttttcaagtatgcta	12	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:179051980A>G	ENST00000326361.3	+	7	1673	c.1228A>G	c.(1228-1230)Aaa>Gaa	p.K410E	ZNF639_ENST00000496856.1_Missense_Mutation_p.K410E|ZNF639_ENST00000484866.1_Missense_Mutation_p.K410E	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	410	Interaction with CTNNA2.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TGACTGTGGGAAAGGCTTTTC	0.323													7	85					0	0	1	0	0	G	179051980	A	G	179051980	3	3	48	1	0	0	0	0	1	0	0	0	18112	247	9	4	1242	4	ZNF639	3	179051980	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	83111	179051980	18970450	1103	5497										
ACTL6A	86	broad.mit.edu	37	chr3	179294470	179294470	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgcagagaactcttccaaGaaatgaatattgaattggtt	9	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:179294470G>T	ENST00000429709.2	+	7	847	c.634G>T	c.(634-636)Gaa>Taa	p.E212*	ACTL6A_ENST00000450518.2_Nonsense_Mutation_p.E170*|ACTL6A_ENST00000467615.1_3'UTR|ACTL6A_ENST00000392662.1_Nonsense_Mutation_p.E170*	NM_004301.3	NP_004292.1	O96019	ACL6A_HUMAN	actin-like 6A	212					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	21	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			ACTCTTCCAAGAAATGAATAT	0.378													22	56					7.45023e-12	9.31775e-12	1	1	0	T	179294470	G	T	179294470	4	4	48	1	0	0	0	0	0	1	0	0	198	943	33	2	660	2	ACTL6A	3	179294470	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	242490	179294470	18727960	1104	5498										
USP13	8975	broad.mit.edu	37	chr3	179426653	179426653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaaagtggttctttgacaGctctgggggcaacgggcatg	16	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:179426653G>A	ENST00000263966.3	+	6	1184	c.713G>A	c.(712-714)aGc>aAc	p.S238N	USP13_ENST00000496897.1_Missense_Mutation_p.S173N|USP13_ENST00000482333.1_3'UTR	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	238					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TTCTTTGACAGCTCTGGGGGC	0.562													4	104					0	0	1	0	0	A	179426653	G	A	179426653	3	1	48	1	0	0	0	0	1	0	0	0	17103	971	34	3	735	3	USP13	3	179426653	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	132183	179426653	18595777	1105	5499										
TTC14	151613	broad.mit.edu	37	chr3	180324343	180324343	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaaactgtccaactcacaGaaatgcaagaaaatacctct	5	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:180324343G>T	ENST00000412756.2	+	9	1193	c.1124G>T	c.(1123-1125)aGa>aTa	p.R375I	TTC14_ENST00000296015.4_Missense_Mutation_p.R375I|TTC14_ENST00000382584.4_Missense_Mutation_p.R375I	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	375							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CCAACTCACAGAAATGCAAGA	0.378													38	64					4.14481e-20	5.66236e-20	1	1	0	T	180324343	G	T	180324343	3	4	48	1	0	0	0	0	1	0	0	0	16742	942	33	2	1158	2	TTC14	3	180324343	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	897690	180324343	17698087	1106	5500										
CCDC39	339829	broad.mit.edu	37	chr3	180334346	180334346	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataatacggatctcagtattTtcttctatgatatcaactaa	4	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:180334346T>C	ENST00000442201.2	-	18	2663	c.2544A>G	c.(2542-2544)gaA>gaG	p.E848E	CCDC39_ENST00000273654.4_3'UTR|TTC14_ENST00000382584.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	848					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCTCAGTATTTTCTTCTATGA	0.284													4	14					0	0	1	0	0	C	180334346	T	C	180334346	2	2	48	1	0	0	0	0	0	0	0	1	2830	1838	64	4		4	CCDC39	3	180334346	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	10003	180334346	17688084	1107	5501										
CCDC39	339829	broad.mit.edu	37	chr3	180334405	180334405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaaactgtttcatttcacGaagtttgatgtcttgttctt	8	6	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:180334405G>A	ENST00000442201.2	-	18	2604	c.2485C>T	c.(2485-2487)Cgt>Tgt	p.R829C	CCDC39_ENST00000273654.4_3'UTR|TTC14_ENST00000382584.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	829					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTCATTTCACGAAGTTTGATG	0.313													3	5					0	0	1	0	0	A	180334405	G	A	180334405	3	1	48	1	0	0	0	0	1	0	0	0	2830	1058	37	1	352	1	CCDC39	3	180334405	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	59	180334405	17688025	1108	5502										
ATP11B	23200	broad.mit.edu	37	chr3	182591616	182591616	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagactacaagataaagttCgagaaactattgaagcattg	8	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:182591616C>T	ENST00000323116.5	+	19	2325	c.2065C>T	c.(2065-2067)Cga>Tga	p.R689*		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	689					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			AGATAAAGTTCGAGAAACTAT	0.323													17	30					0	0	1	0	0	T	182591616	C	T	182591616	4	4	48	1	0	0	0	0	0	1	0	0	1119	876	31	1	2139	1	ATP11B	3	182591616	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2257211	182591616	15430814	1109	5503										
MCF2L2	23101	broad.mit.edu	37	chr3	182925518	182925518	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctggctgggtttaaatcGaatcaaatccttcattttat	6	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:182925518G>A	ENST00000328913.3	-	23	2887	c.2590C>T	c.(2590-2592)Cga>Tga	p.R864*	MCF2L2_ENST00000473233.1_Nonsense_Mutation_p.R864*	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	864	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGTTTAAATCGAATCAAATCC	0.438													20	44					0	0	1	0	0	A	182925518	G	A	182925518	4	1	48	1	0	0	0	0	0	1	0	0	9429	1066	37	1	786	1	MCF2L2	3	182925518	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	333902	182925518	15096912	1110	5504										
KLHL24	54800	broad.mit.edu	37	chr3	183368270	183368270	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcatgagttttttgacttCtcttcaggatcatcccatgc	8	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:183368270C>A	ENST00000454652.1	+	4	512	c.126C>A	c.(124-126)ttC>ttA	p.F42L	KLHL24_ENST00000242810.6_Missense_Mutation_p.F42L|KLHL24_ENST00000476808.1_Missense_Mutation_p.F42L			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	42						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TTTTTGACTTCTCTTCAGGAT	0.408													20	54					1.33834e-09	1.61283e-09	1	1	0	A	183368270	C	A	183368270	3	1	48	1	0	0	0	0	1	0	0	0	8421	912	32	2	128	2	KLHL24	3	183368270	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	442752	183368270	14654160	1111	5505										
YEATS2	55689	broad.mit.edu	37	chr3	183479328	183479328	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttgcatctatgccacctCtttgcccaattgggagtcac	8	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:183479328C>T	ENST00000305135.5	+	14	1885	c.1690C>T	c.(1690-1692)Ctt>Ttt	p.L564F		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	564					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TATGCCACCTCTTTGCCCAAT	0.413													50	86					0	0	1	0	0	T	183479328	C	T	183479328	3	4	48	1	0	0	0	0	1	0	0	0	17531	913	32	3	1740	3	YEATS2	3	183479328	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	111058	183479328	14543102	1112	5506										
ECE2	9718	broad.mit.edu	37	chr3	183995240	183995240	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaccaaaaccaggccatacTgaagcacctgcttggtgagt	11	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:183995240T>C	ENST00000402825.3	+	4	818	c.818T>C	c.(817-819)cTg>cCg	p.L273P	ECE2_ENST00000404464.3_Missense_Mutation_p.L155P|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Missense_Mutation_p.L126P|ECE2_ENST00000357474.5_Missense_Mutation_p.L201P	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	273	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAGGCCATACTGAAGCACCTG	0.602													20	33					0	0	1	0	0	C	183995240	T	C	183995240	3	2	48	1	0	0	0	0	1	0	0	0	4916	1580	55	4	1396	4	ECE2	3	183995240	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	515912	183995240	14027190	1113	5507										
MAGEF1	64110	broad.mit.edu	37	chr3	184428893	184428893	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcttcggggaccccaagaGaattcatattctggtggatt	11	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:184428893G>T	ENST00000317897.3	-	1	943	c.717C>A	c.(715-717)ttC>ttA	p.F239L		NM_022149.4	NP_071432.2	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	239	MAGE.									breast(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			GACCCCAAGAGAATTCATATT	0.507													19	45					6.94344e-10	8.4399e-10	1	1	0	T	184428893	G	T	184428893	3	4	48	1	0	0	0	0	1	0	0	0	9236	933	33	2	210	2	MAGEF1	3	184428893	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	433653	184428893	13593537	1114	5508										
VPS8	23355	broad.mit.edu	37	chr3	184542494	184542494	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcgaagaagagctgaataAgtctttcaatctagaagctt	10	6	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:184542494A>C	ENST00000437079.3	+	2	245	c.74A>C	c.(73-75)aAg>aCg	p.K25T	VPS8_ENST00000436792.2_Missense_Mutation_p.K25T|VPS8_ENST00000424463.2_Missense_Mutation_p.K25T|VPS8_ENST00000446204.2_Missense_Mutation_p.K25T|VPS8_ENST00000287546.4_Missense_Mutation_p.K25T	NM_001009921.2	NP_001009921.1	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	25							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GAGCTGAATAAGTCTTTCAAT	0.358													8	44					0	0	1	0	0	C	184542494	A	C	184542494	3	2	48	1	0	0	0	0	1	0	0	0	17277	72	3	4	76	4	VPS8	3	184542494	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	113601	184542494	13479936	1115	5509										
TMEM41A	90407	broad.mit.edu	37	chr3	185214663	185214663	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccctgtttgtagaggtaggCgccgcagaagagcaggaaca	15	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:185214663C>T	ENST00000421852.1	-	2	321	c.226G>A	c.(226-228)Gcc>Acc	p.A76T	TMEM41A_ENST00000475480.1_5'UTR|TMEM41A_ENST00000296254.3_Missense_Mutation_p.A76T	NM_080652.3	NP_542383.1	Q96HV5	TM41A_HUMAN	transmembrane protein 41A	76						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TAGAGGTAGGCGCCGCAGAAG	0.587													14	13					0	0	1	0	0	T	185214663	C	T	185214663	3	4	48	1	0	0	0	0	1	0	0	0	16223	768	27	1	584	1	TMEM41A	3	185214663	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	672169	185214663	12807767	1116	5510										
TRA2B	6434	broad.mit.edu	37	chr3	185643396	185643396	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggtataatgccttcgggaGcttcttctggatctagacct	11	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:185643396G>A	ENST00000453386.2	-	3	464	c.189C>T	c.(187-189)agC>agT	p.S63S	TRA2B_ENST00000382191.4_5'UTR	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	63	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						GCCTTCGGGAGCTTCTTCTGG	0.458													15	31					0	0	1	0	0	A	185643396	G	A	185643396	2	1	48	1	0	0	0	0	0	0	0	1	16494	962	34	3		3	TRA2B	3	185643396	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	428733	185643396	12379034	1117	5511										
DGKG	1608	broad.mit.edu	37	chr3	186024714	186024714	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgggtcatattgtttgagGctcccaccctcattaaattc	8	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:186024714G>A	ENST00000265022.3	-	3	659	c.120C>T	c.(118-120)agC>agT	p.S40S	DGKG_ENST00000382164.4_Silent_p.S40S|DGKG_ENST00000344484.4_Silent_p.S40S|DGKG_ENST00000544847.1_Silent_p.S40S	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	40					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	ATTGTTTGAGGCTCCCACCCT	0.383													21	28					0	0	1	0	0	A	186024714	G	A	186024714	2	1	48	1	0	0	0	0	0	0	0	1	4497	1194	42	3		3	DGKG	3	186024714	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	381318	186024714	11997716	1118	5512										
AHSG	197	broad.mit.edu	37	chr3	186331076	186331076	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtggctatagactacatcaAtcaaaaccttccttggggat	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:186331076A>C	ENST00000411641.2	+	1	365	c.146A>C	c.(145-147)aAt>aCt	p.N49T	AHSG_ENST00000273784.5_Missense_Mutation_p.N49T			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	49	Cystatin fetuin-A-type 1.				acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GACTACATCAATCAAAACCTT	0.478													16	37					0	0	1	0	0	C	186331076	A	C	186331076	3	2	48	1	0	0	0	0	1	0	0	0	417	101	4	4	148	4	AHSG	3	186331076	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	306362	186331076	11691354	1119	5513										
KNG1	3827	broad.mit.edu	37	chr3	186460097	186460097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaagaatcttattatttcGatctcactgatggcctttct	6	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:186460097G>A	ENST00000265023.4	+	10	2124	c.1912G>A	c.(1912-1914)Gat>Aat	p.D638N	KNG1_ENST00000287611.2_Intron|KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000354642.2_RNA|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	638					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	TTATTATTTCGATCTCACTGA	0.373													28	46					0	0	1	0	0	A	186460097	G	A	186460097	3	1	48	1	0	0	0	0	1	0	0	0	8469	1058	37	1	1950	1	KNG1	3	186460097	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	129021	186460097	11562333	1120	5514										
RTP4	64108	broad.mit.edu	37	chr3	187089081	187089081	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgagaaattagggcccagtCgagacccagatccactgaac	10	11	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:187089081C>T	ENST00000259030.2	+	2	771	c.661C>T	c.(661-663)Cga>Tga	p.R221*		NM_022147.2	NP_071430.2	Q96DX8	RTP4_HUMAN	receptor (chemosensory) transporter protein 4	221					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		AGGGCCCAGTCGAGACCCAGA	0.448													10	44					0	0	1	0	0	T	187089081	C	T	187089081	4	4	48	1	0	0	0	0	0	1	0	0	13787	876	31	1	667	1	RTP4	3	187089081	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	628984	187089081	10933349	1121	5515										
BCL6	604	broad.mit.edu	37	chr3	187451396	187451396	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacaacatcagtcaagatgTctcgactccggagacgatta	9	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:187451396T>C	ENST00000406870.2	-	3	452	c.86A>G	c.(85-87)gAc>gGc	p.D29G	BCL6_ENST00000450123.2_Missense_Mutation_p.D29G|RP11-211G3.3_ENST00000449623.1_Missense_Mutation_p.S72P|BCL6_ENST00000232014.4_Missense_Mutation_p.D29G	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	29					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		AGTCAAGATGTCTCGACTCCG	0.512			"T, Mis"	"IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"	"NHL, CLL"								42	96					0	0	1	0	0	C	187451396	T	C	187451396	3	2	48	1	0	0	0	0	1	0	0	0	1374	1667	58	4	2066	4	BCL6	3	187451396	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	362315	187451396	10571034	1122	5516										
IL1RAP	0	broad.mit.edu	37	chr3	190363530	190363530	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtatcctatgcaaggaatgCggaagaagaagaatttgtat	11	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:190363530C>T	ENST00000412504.2	+	10	1496	c.1244C>T	c.(1243-1245)gCg>gTg	p.A415V	IL1RAP_ENST00000443369.2_Missense_Mutation_p.A415V|IL1RAP_ENST00000072516.3_Missense_Mutation_p.A415V|IL1RAP_ENST00000447382.1_Missense_Mutation_p.A415V|IL1RAP_ENST00000439062.1_Missense_Mutation_p.A415V|IL1RAP_ENST00000317757.3_Missense_Mutation_p.A415V			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	415	TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		GCAAGGAATGCGGAAGAAGAA	0.388													15	18					0	0	1	0	0	T	190363530	C	T	190363530	3	4	48	1	0	0	0	0	1	0	0	0	7703	768	27	1	1298	1	IL1RAP	3	190363530	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2912134	190363530	7658900	1123	5517										
OSTN	344901	broad.mit.edu	37	chr3	190936632	190936632	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaactcttgcttcttgatGaattggtgtccctagaaaat	7	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:190936632G>T	ENST00000445281.1	+	3	266	c.199G>T	c.(199-201)Gaa>Taa	p.E67*	OSTN_ENST00000339051.1_Nonsense_Mutation_p.E67*|OSTN-AS1_ENST00000430375.1_RNA			P61366	OSTN_HUMAN	osteocrin	67					cell differentiation|multicellular organismal development|ossification		hormone activity			kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|skin(2)	13	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		GCTTCTTGATGAATTGGTGTC	0.453													13	30					3.03607e-14	3.94451e-14	1	1	0	T	190936632	G	T	190936632	4	4	48	1	0	0	0	0	0	1	0	0	11345	1291	45	2	205	2	OSTN	3	190936632	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	573102	190936632	7085798	1124	5518										
ATP13A5	344905	broad.mit.edu	37	chr3	193049090	193049090	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggccatggtcacagtatctTttggaggaacctgggagagg	16	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:193049090T>G	ENST00000342358.4	-	12	1400	c.1283A>C	c.(1282-1284)aAa>aCa	p.K428T		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	428					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CACAGTATCTTTTGGAGGAAC	0.542													15	23					0	0	1	0	0	G	193049090	T	G	193049090	3	3	48	1	0	0	0	0	1	0	0	0	1126	1841	64	4	2447	4	ATP13A5	3	193049090	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2112458	193049090	4973340	1125	5519										
ATP13A4	84239	broad.mit.edu	37	chr3	193207521	193207521	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attaatagaaaaactcacctCtctgagatcatatactgtca	4	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:193207521C>A	ENST00000342695.4	-	7	1058	c.736G>T	c.(736-738)Gag>Tag	p.E246*	ATP13A4_ENST00000392443.3_Nonsense_Mutation_p.E246*|ATP13A4_ENST00000295548.3_Nonsense_Mutation_p.E246*	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	246					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AAACTCACCTCTCTGAGATCA	0.318													18	83					1.67942e-08	1.98515e-08	1	1	0	A	193207521	C	A	193207521	4	1	48	1	0	0	0	0	0	1	0	0	1125	922	32	2	2950	2	ATP13A4	3	193207521	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	158431	193207521	4814909	1126	5520										
OPA1	4976	broad.mit.edu	37	chr3	193332780	193332780	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctacgagactcttaaaacttCgctatctcatactaggatcg	6	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:193332780C>T	ENST00000361510.2	+	2	535	c.301C>T	c.(301-303)Cgc>Tgc	p.R101C	OPA1_ENST00000487986.1_3'UTR|OPA1_ENST00000361828.2_Missense_Mutation_p.R101C|OPA1_ENST00000392438.3_Missense_Mutation_p.R101C|OPA1_ENST00000361150.2_Missense_Mutation_p.R101C|OPA1_ENST00000361908.3_Missense_Mutation_p.R101C|OPA1_ENST00000361715.2_Missense_Mutation_p.R101C	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	101					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CTTAAAACTTCGCTATCTCAT	0.413													18	34					0	0	1	0	0	T	193332780	C	T	193332780	3	4	48	1	0	0	0	0	1	0	0	0	10918	884	31	1	307	1	OPA1	3	193332780	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	125259	193332780	4689650	1127	5521										
APOD	347	broad.mit.edu	37	chr3	195300766	195300766	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttccgttttccattagtGagtagttggcctggatgcag	11	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:195300766G>T	ENST00000343267.3	-	3	561	c.200C>A	c.(199-201)tCa>tAa	p.S67*		NM_001647.3	NP_001638.1	P05090	APOD_HUMAN	apolipoprotein D	67					lipid metabolic process	extracellular space	lipid binding|lipid transporter activity|protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		TTCCATTAGTGAGTAGTTGGC	0.512													6	61					0.0293803	0.0299069	1	1	0	T	195300766	G	T	195300766	4	4	48	1	0	0	0	0	0	1	0	0	798	1294	45	2	381	2	APOD	3	195300766	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1967986	195300766	2721664	1128	5522										
MUC4	4585	broad.mit.edu	37	chr3	195481210	195481210	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagccctcgcagtagcggcCgaaggtgcccccgtcacact	13	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:195481210C>T	ENST00000463781.3	-	19	15661	c.15202G>A	c.(15202-15204)Ggc>Agc	p.G5068S	MUC4_ENST00000346145.4_Missense_Mutation_p.G832S|MUC4_ENST00000349607.4_Missense_Mutation_p.G781S|MUC4_ENST00000475231.1_Missense_Mutation_p.G5016S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1825					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CAGTAGCGGCCGAAGGTGCCC	0.657													6	55					0	0	1	0	0	T	195481210	C	T	195481210	3	4	48	1	0	0	0	0	1	0	0	0	10025	652	23	1	1064	1	MUC4	3	195481210	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	180444	195481210	2541220	1129	5523										
MUC4	4585	broad.mit.edu	37	chr3	195505212	195505212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatgggggcagctgtggagCgggtgtgcatggcagtgctg	22	6	0	0	rs141462807	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:195505212C>T	ENST00000463781.3	-	3	13364	c.12905G>A	c.(12904-12906)cGc>cAc	p.R4302H	MUC4_ENST00000346145.4_Missense_Mutation_p.R66H|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.R4302H	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1059					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGCTGTGGAGCGGGTGTGCAT	0.597													23	43					0	0	1	0	0	T	195505212	C	T	195505212	3	4	48	1	0	0	0	0	1	0	0	0	10025	768	27	1	3425	1	MUC4	3	195505212	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	24002	195505212	2517218	1130	5524										
RNF168	165918	broad.mit.edu	37	chr3	196199276	196199276	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttactgatcagtaggcacGactcttcattttctgtctca	6	12	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:196199276G>A	ENST00000318037.3	-	6	1724	c.1130C>T	c.(1129-1131)tCg>tTg	p.S377L		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	377					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		CAGTAGGCACGACTCTTCATT	0.443													39	64					0	0	1	0	0	A	196199276	G	A	196199276	3	1	48	1	0	0	0	0	1	0	0	0	13510	1059	37	1	589	1	RNF168	3	196199276	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	694064	196199276	1823154	1131	5525										
SENP5	205564	broad.mit.edu	37	chr3	196650379	196650379	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actctctaatcgaattatttCattttatgattcccaaggca	4	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr3:196650379C>A	ENST00000323460.5	+	7	2228	c.1979C>A	c.(1978-1980)tCa>tAa	p.S660*	SENP5_ENST00000445299.2_Intron|SENP5_ENST00000419026.1_Nonsense_Mutation_p.S150*	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	660	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		CGAATTATTTCATTTTATGAT	0.333													12	40					2.27111e-07	2.60515e-07	1	1	0	A	196650379	C	A	196650379	4	1	48	1	0	0	0	0	0	1	0	0	14102	838	29	2	2001	2	SENP5	3	196650379	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	451103	196650379	1372051	1132	5526										
ZNF721	170960	broad.mit.edu	37	chr4	435658	435658	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttgccacattctccacaTgtgtagggtttctctccagt	8	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:435658T>C	ENST00000338977.5	-	2	2610	c.2562A>G	c.(2560-2562)acA>acG	p.T854T	ZNF721_ENST00000506646.1_Intron|ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000511833.2_Silent_p.T866T|ZNF721_ENST00000507078.1_Intron					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						ATTCTCCACATGTGTAGGGTT	0.423													20	28					0	0	1	0	0	C	435658	T	C	435658	2	2	48	1	0	0	0	0	0	0	0	1	18175	1451	51	4		4	ZNF721	4	435658	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08		435658	190718618	1133	5527										
ZNF721	170960	broad.mit.edu	37	chr4	436594	436594	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcacatgtgtagggtttCtctccagtatgaattctcct	7	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:436594C>A	ENST00000338977.5	-	2	1674	c.1626G>T	c.(1624-1626)gaG>gaT	p.E542D	ZNF721_ENST00000506646.1_Intron|ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000511833.2_Missense_Mutation_p.E554D|ZNF721_ENST00000507078.1_Intron					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						TGTAGGGTTTCTCTCCAGTAT	0.403													38	67					1.03484e-13	1.33003e-13	1	1	0	A	436594	C	A	436594	3	1	48	1	0	0	0	0	1	0	0	0	18175	912	32	2	1113	2	ZNF721	4	436594	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	936	436594	190717682	1134	5528										
PDE6B	5158	broad.mit.edu	37	chr4	654306	654306	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacatctacgaattccacttCtctgacctggagtgcaccga	8	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:654306C>A	ENST00000255622.6	+	12	1561	c.1518C>A	c.(1516-1518)ttC>ttA	p.F506L	PDE6B_ENST00000496514.1_Missense_Mutation_p.F506L|PDE6B_ENST00000429163.2_Missense_Mutation_p.F227L	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	506					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						AATTCCACTTCTCTGACCTGG	0.592													15	23					1.05317e-09	1.27574e-09	1	1	0	A	654306	C	A	654306	3	1	48	1	0	0	0	0	1	0	0	0	11692	912	32	2	1564	2	PDE6B	4	654306	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	217712	654306	190499970	1135	5529										
SLBP	7884	broad.mit.edu	37	chr4	1698041	1698041	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actatacttcttaaatttatTaggggtcttgggatgaatgc	9	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:1698041T>G	ENST00000489418.1	-	6	883	c.517A>C	c.(517-519)Aat>Cat	p.N173H	SLBP_ENST00000318386.4_Missense_Mutation_p.N180H|SLBP_ENST00000488267.1_Missense_Mutation_p.N138H|SLBP_ENST00000429429.2_Missense_Mutation_p.N134H	NM_006527.2	NP_006518.1	Q14493	SLBP_HUMAN	stem-loop binding protein	173	RNA-binding.				DNA replication involved in S phase|histone mRNA 3'-end processing|mRNA export from nucleus|regulation of S phase|termination of RNA polymerase II transcription	cytosol|histone pre-mRNA 3'end processing complex|nucleoplasm	histone pre-mRNA DCP binding|histone pre-mRNA stem-loop binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)	5		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.0055)			TTAAATTTATTAGGGGTCTTG	0.458													28	97					0	0	1	0	0	G	1698041	T	G	1698041	3	3	48	1	0	0	0	0	1	0	0	0	14426	1754	61	4	307	4	SLBP	4	1698041	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1043735	1698041	189456235	1136	5530										
POLN	353497	broad.mit.edu	37	chr4	2210083	2210083	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tactgtggaattaaacaactTgaaagagtcaatgagctgat	9	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:2210083T>G	ENST00000511885.2	-	5	698	c.345A>C	c.(343-345)tcA>tcC	p.S115S	POLN_ENST00000515357.1_5'UTR|POLN_ENST00000382865.1_Silent_p.S115S			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	115					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TTAAACAACTTGAAAGAGTCA	0.398								DNA polymerases (catalytic subunits)					28	48					0	0	1	0	0	G	2210083	T	G	2210083	2	3	48	1	0	0	0	0	0	0	0	1	12254	1799	63	4		4	POLN	4	2210083	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	512042	2210083	188944193	1137	5531										
HAUS3	79441	broad.mit.edu	37	chr4	2242595	2242595	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccctcaaacaaccagtcaaAgtcttctccattaagattat	4	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:2242595A>C	ENST00000243706.4	-	2	308	c.79T>G	c.(79-81)Ttt>Gtt	p.F27V	POLN_ENST00000515357.1_Intron|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000443786.2_Missense_Mutation_p.F27V|HAUS3_ENST00000506763.1_Missense_Mutation_p.F27V	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	27					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						AACCAGTCAAAGTCTTCTCCA	0.373													8	68					0	0	1	0	0	C	2242595	A	C	2242595	3	2	48	1	0	0	0	0	1	0	0	0	7007	72	3	4	1748	4	HAUS3	4	2242595	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	32512	2242595	188911681	1138	5532										
GRK4	2868	broad.mit.edu	37	chr4	3011413	3011413	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatttagacattacagagTtctaggaaaaggcggatttg	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:3011413T>C	ENST00000398052.4	+	7	918	c.575T>C	c.(574-576)gTt>gCt	p.V192A	GRK4_ENST00000398051.4_Missense_Mutation_p.V160A|GRK4_ENST00000345167.6_Missense_Mutation_p.V160A|GRK4_ENST00000504933.1_Missense_Mutation_p.V192A	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	192	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CATTACAGAGTTCTAGGAAAA	0.443													8	54					0	0	1	0	0	C	3011413	T	C	3011413	3	2	48	1	0	0	0	0	1	0	0	0	6831	1725	60	4	601	4	GRK4	4	3011413	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	768818	3011413	188142863	1139	5533										
HTT	3064	broad.mit.edu	37	chr4	3231768	3231768	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcagctgccgtccttgggaTggtaagtgacaggtggcaca	16	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:3231768T>G	ENST00000355072.5	+	60	8409	c.8265_splice	c.e60+1	p.M2755_splice	HTT_ENST00000513806.1_3'UTR	NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2755					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTCCTTGGGATGGTAAGTGAC	0.627													4	63					0	0	1	0	0	G	3231768	T	G	3231768	5	3	48	1	0	0	0	0	0	0	1	0	7500	1478	51	4	8502	4	HTT	4	3231768	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	220355	3231768	187922508	1140	5534										
HGFAC	3083	broad.mit.edu	37	chr4	3449289	3449289	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacgacggacgtgacgcagAccttcggcatcgagaagtac	13	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:3449289A>C	ENST00000382774.3	+	11	1541	c.1426A>C	c.(1426-1428)Acc>Ccc	p.T476P	HGFAC_ENST00000511533.1_Missense_Mutation_p.T483P	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	476	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CGTGACGCAGACCTTCGGCAT	0.647													123	256					0	0	1	0	0	C	3449289	A	C	3449289	3	2	48	1	0	0	0	0	1	0	0	0	7126	275	10	4	1468	4	HGFAC	4	3449289	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	217521	3449289	187704987	1141	5535										
LRPAP1	4043	broad.mit.edu	37	chr4	3517921	3517921	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaatcaccctgggctcctcGaactctgcaggggaggagca	12	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:3517921G>A	ENST00000500728.2	-	6	902	c.756C>T	c.(754-756)ttC>ttT	p.F252F	LRPAP1_ENST00000296325.5_5'UTR	NM_002337.3	NP_002328.1	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein associated protein 1	252	LDL receptor binding (Potential).				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		TGGGCTCCTCGAACTCTGCAG	0.657													3	4					0	0	1	0	0	A	3517921	G	A	3517921	2	1	48	1	0	0	0	0	0	0	0	1	9008	1049	37	1		1	LRPAP1	4	3517921	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	68632	3517921	187636355	1142	5536										
CYTL1	54360	broad.mit.edu	37	chr4	5018861	5018861	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccagggagaaccctcttaCgtgtatgtccaggtacagcc	10	14	1	1	rs144723757		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:5018861C>T	ENST00000307746.4	-	2	225		c.e2+1			NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1						signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		AACCCTCTTACGTGTATGTCC	0.572													15	30					0	0	1	0	0	T	5018861	C	T	5018861	5	4	48	1	0	0	0	0	0	0	1	0	4231	550	19	1	223	1	CYTL1	4	5018861	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1500940	5018861	186135415	1143	5537										
EVC2	132884	broad.mit.edu	37	chr4	5564756	5564756	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtacaggggccagttcgccaAtgggctccagtgacaggtgt	15	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:5564756A>T	ENST00000310917.2	-	22	4237	c.3506T>A	c.(3505-3507)aTt>aAt	p.I1169N	EVC2_ENST00000344408.5_Missense_Mutation_p.I1249N|EVC2_ENST00000344938.1_Intron	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1249						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CAGTTCGCCAATGGGCTCCAG	0.448													39	96					0	0	1	0	0	T	5564756	A	T	5564756	3	4	48	1	0	0	0	0	1	0	0	0	5314	101	4	4	184	4	EVC2	4	5564756	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	545895	5564756	185589520	1144	5538										
C4orf50	389197	broad.mit.edu	37	chr4	5961108	5961108	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgagtggccctattacatTtctaactccagcggtgattt	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:5961108T>G	ENST00000531445.1	-	7	2293	c.2247A>C	c.(2245-2247)gaA>gaC	p.E749D	C4orf50_ENST00000324058.5_Missense_Mutation_p.E275D			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	275										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						CCTATTACATTTCTAACTCCA	0.448													38	61					0	0	1	0	0	G	5961108	T	G	5961108	3	3	48	1	0	0	0	0	1	0	0	0	2291	1838	64	4	9	4	C4orf50	4	5961108	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	396352	5961108	185193168	1145	5539										
KIAA0232	9778	broad.mit.edu	37	chr4	6843914	6843914	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggctgctgtccagtgtcttCgatctgcttctgatgaagta	11	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:6843914C>T	ENST00000307659.5	+	4	807	c.352C>T	c.(352-354)Cga>Tga	p.R118*	KIAA0232_ENST00000425103.1_Nonsense_Mutation_p.R118*	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	118							ATP binding	p.R118*(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						CCAGTGTCTTCGATCTGCTTC	0.348													23	43					0	0	1	0	0	T	6843914	C	T	6843914	4	4	48	1	0	0	0	0	0	1	0	0	8204	876	31	1	358	1	KIAA0232	4	6843914	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	882806	6843914	184310362	1146	5540										
AFAP1	60312	broad.mit.edu	37	chr4	7844978	7844978	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaccaggtccatggaggccTcctcggagggccactggtgc	15	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:7844978T>C	ENST00000420658.1	-	5	706	c.434A>G	c.(433-435)gAg>gGg	p.E145G	AFAP1_ENST00000382543.3_Missense_Mutation_p.E145G|AFAP1_ENST00000360265.4_Missense_Mutation_p.E145G|AFAP1_ENST00000358461.2_Missense_Mutation_p.E145G	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	145						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CATGGAGGCCTCCTCGGAGGG	0.562													8	25					0	0	1	0	0	C	7844978	T	C	7844978	3	2	48	1	0	0	0	0	1	0	0	0	352	1551	54	4	2066	4	AFAP1	4	7844978	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1001064	7844978	183309298	1147	5541										
CPZ	8532	broad.mit.edu	37	chr4	8621305	8621305	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtggtcctacttcacatcGctgagcacccacaggccacg	10	15	1	1	rs139174553	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:8621305G>A	ENST00000429646.2	+	9	3537	c.744G>A	c.(742-744)tcG>tcA	p.S248S	CPZ_ENST00000382480.2_Silent_p.S503S|CPZ_ENST00000360986.4_Silent_p.S640S|CPZ_ENST00000315782.6_Silent_p.S629S			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	640					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACTTCACATCGCTGAGCACCC	0.706													18	31					0	0	1	0	0	A	8621305	G	A	8621305	2	1	48	1	0	0	0	0	0	0	0	1	3862	1074	38	1		1	CPZ	4	8621305	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	776327	8621305	182532971	1148	5542										
CLNK	116449	broad.mit.edu	37	chr4	10515153	10515153	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatagggcagtatattttCgtgagggctgcagctggctg	14	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:10515153C>T	ENST00000226951.6	-	16	1080	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	CLNK_ENST00000515667.1_Missense_Mutation_p.E19K	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	281					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						AGTATATTTTCGTGAGGGCTG	0.473													4	12					0	0	1	0	0	T	10515153	C	T	10515153	3	4	48	1	0	0	0	0	1	0	0	0	3570	893	31	1	461	1	CLNK	4	10515153	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1893848	10515153	180639123	1149	5543										
FBXL5	26234	broad.mit.edu	37	chr4	15642453	15642453	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagaaaatctcttgtaaaAgcctccaatctctctttcag	6	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:15642453A>C	ENST00000341285.3	-	3	478	c.354T>G	c.(352-354)gcT>gcG	p.A118A	FBXL5_ENST00000412094.2_Silent_p.A101A|FBXL5_ENST00000382358.4_5'UTR	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	118	Hemerythrin-like.				iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						CTCTTGTAAAAGCCTCCAATC	0.279													7	27					0	0	1	0	0	C	15642453	A	C	15642453	2	2	48	1	0	0	0	0	0	0	0	1	5754	59	3	4		4	FBXL5	4	15642453	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5127300	15642453	175511823	1150	5544										
FBXL5	26234	broad.mit.edu	37	chr4	15646324	15646324	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttgttggaaaaattggttTtagaaagctgaataaaaatt	9	1	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:15646324T>G	ENST00000341285.3	-	2	216	c.92A>C	c.(91-93)aAa>aCa	p.K31T	FBXL5_ENST00000412094.2_Intron|FBXL5_ENST00000382358.4_5'UTR	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	31	Hemerythrin-like.				iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						AAAATTGGTTTTAGAAAGCTG	0.303													13	12					0	0	1	0	0	G	15646324	T	G	15646324	3	3	48	1	0	0	0	0	1	0	0	0	5754	1841	64	4	2023	4	FBXL5	4	15646324	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3871	15646324	175507952	1151	5545										
BST1	683	broad.mit.edu	37	chr4	15706562	15706562	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcaaataagaaacagcagaGaaccacctgtgttacacacc	8	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:15706562G>T	ENST00000382346.3	+	2	257	c.208G>T	c.(208-210)Gaa>Taa	p.E70*	BST1_ENST00000265016.4_Intron			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	63					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						AAACAGCAGAGAACCACCTGT	0.403													3	7					1	1	1	1	0	T	15706562	G	T	15706562	4	4	48	1	0	0	0	0	0	1	0	0	1535	957	33	2		2	BST1	4	15706562	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	60238	15706562	175447714	1152	5546										
LAP3	51056	broad.mit.edu	37	chr4	17586709	17586709	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaccagatttgctgaaatTattgagaagaatctcaaaag	7	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:17586709T>G	ENST00000226299.4	+	6	928	c.654T>G	c.(652-654)atT>atG	p.I218M	LAP3_ENST00000606142.1_Missense_Mutation_p.I187M	NM_015907.2	NP_056991.2	P28838	AMPL_HUMAN	leucine aminopeptidase 3	218					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|urinary_tract(1)	20						TTGCTGAAATTATTGAGAAGA	0.473													4	106					0	0	1	0	0	G	17586709	T	G	17586709	3	3	48	1	0	0	0	0	1	0	0	0	8661	1742	61	4	676	4	LAP3	4	17586709	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1880147	17586709	173567567	1153	5547										
DCAF16	54876	broad.mit.edu	37	chr4	17805494	17805494	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtcttagacctatctctcGaagtatatggactggtgtgc	11	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:17805494G>A	ENST00000382247.1	-	3	1331	c.271C>T	c.(271-273)Cga>Tga	p.R91*	DCAF16_ENST00000536863.1_Nonsense_Mutation_p.R91*	NM_017741.3	NP_060211.3	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	91						CUL4 RING ubiquitin ligase complex				cervix(1)|endometrium(1)|lung(2)|ovary(1)	5						CCTATCTCTCGAAGTATATGG	0.448													53	89					0	0	1	0	0	A	17805494	G	A	17805494	4	1	48	1	0	0	0	0	0	1	0	0	4292	1066	37	1	383	1	DCAF16	4	17805494	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	218785	17805494	173348782	1154	5548										
NCAPG	64151	broad.mit.edu	37	chr4	17824682	17824682	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggaaatttgatgacaaaaGaattcataggtcaacaattg	8	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:17824682G>T	ENST00000251496.2	+	8	1371	c.1195G>T	c.(1195-1197)Gaa>Taa	p.E399*		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	399					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		GATGACAAAAGAATTCATAGG	0.323													11	22					0.000673444	0.000709932	1	1	0	T	17824682	G	T	17824682	4	4	48	1	0	0	0	0	0	1	0	0	10253	943	33	2	1225	2	NCAPG	4	17824682	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19188	17824682	173329594	1155	5549										
SLIT2	9353	broad.mit.edu	37	chr4	20525762	20525762	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgccgcctggcaaacaaaaGaattggacagatcaaaagca	9	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:20525762G>T	ENST00000504154.1	+	14	1652	c.1400G>T	c.(1399-1401)aGa>aTa	p.R467I	SLIT2_ENST00000273739.5_Missense_Mutation_p.R471I|SLIT2_ENST00000503823.1_Missense_Mutation_p.R467I|SLIT2_ENST00000503837.1_Missense_Mutation_p.R471I	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	467	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GCAAACAAAAGAATTGGACAG	0.478													45	124					5.78141e-17	7.72733e-17	1	1	0	T	20525762	G	T	20525762	3	4	48	1	0	0	0	0	1	0	0	0	14793	942	33	2	1454	2	SLIT2	4	20525762	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2701080	20525762	170628514	1156	5550										
KCNIP4	80333	broad.mit.edu	37	chr4	20734383	20734383	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttacccatcatatcgtatAttgctttcattatatcaagc	3	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:20734383A>C	ENST00000382148.3	-	6	824	c.488T>G	c.(487-489)aTa>aGa	p.I163R	KCNIP4_ENST00000382152.2_Missense_Mutation_p.I188R|KCNIP4_ENST00000447367.2_Missense_Mutation_p.I154R|KCNIP4_ENST00000509207.1_Missense_Mutation_p.I126R|PACRGL_ENST00000507634.1_Intron|KCNIP4_ENST00000382150.4_Missense_Mutation_p.I167R|KCNIP4_ENST00000359001.5_Missense_Mutation_p.I126R|KCNIP4_ENST00000382149.4_5'UTR	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	188	EF-hand 3.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				CATATCGTATATTGCTTTCAT	0.373													9	19					0	0	1	0	0	C	20734383	A	C	20734383	3	2	48	1	0	0	0	0	1	0	0	0	8085	449	16	4	201	4	KCNIP4	4	20734383	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	208621	20734383	170419893	1157	5551										
KCNIP4	80333	broad.mit.edu	37	chr4	20852208	20852208	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgaagctctttcttggtAaatttgctctgggcttccag	9	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:20852208A>C	ENST00000382148.3	-	2	507	c.171T>G	c.(169-171)ttT>ttG	p.F57L	KCNIP4_ENST00000382152.2_Missense_Mutation_p.F82L|KCNIP4_ENST00000447367.2_Missense_Mutation_p.F48L|KCNIP4_ENST00000509207.1_Missense_Mutation_p.F20L|KCNIP4_ENST00000382150.4_Missense_Mutation_p.F61L|KCNIP4_ENST00000359001.5_Missense_Mutation_p.F20L|KCNIP4_ENST00000382149.4_5'UTR	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	82						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				CTTTCTTGGTAAATTTGCTCT	0.448													29	47					0	0	1	0	0	C	20852208	A	C	20852208	3	2	48	1	0	0	0	0	1	0	0	0	8085	359	13	4	534	4	KCNIP4	4	20852208	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	117825	20852208	170302068	1158	5552										
GPR125	166647	broad.mit.edu	37	chr4	22390389	22390389	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatcctgatgatttatttCgccattttcattggctgcca	7	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:22390389C>T	ENST00000334304.5	-	19	3174	c.2905G>A	c.(2905-2907)Gaa>Aaa	p.E969K	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	969					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity	p.E969K(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TGATTTATTTCGCCATTTTCA	0.438													29	43					0	0	1	0	0	T	22390389	C	T	22390389	3	4	48	1	0	0	0	0	1	0	0	0	6678	893	31	1	1064	1	GPR125	4	22390389	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1538181	22390389	168763887	1159	5553										
PPARGC1A	10891	broad.mit.edu	37	chr4	23815615	23815615	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgaatttataaacataggTagtttggagaattgttcatt	8	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:23815615T>C	ENST00000264867.2	-	8	1610	c.1491A>G	c.(1489-1491)ctA>ctG	p.L497L	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	497					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TAAACATAGGTAGTTTGGAGA	0.453													34	56					0	0	1	0	0	C	23815615	T	C	23815615	2	2	48	1	0	0	0	0	0	0	0	1	12344	1625	57	4		4	PPARGC1A	4	23815615	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1425226	23815615	167338661	1160	5554										
ANAPC4	29945	broad.mit.edu	37	chr4	25418156	25418156	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactcttggtccagctgcctTtgtctttagtatataacagt	8	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:25418156T>C	ENST00000315368.3	+	27	2153	c.2011T>C	c.(2011-2013)Ttg>Ctg	p.L671L	ANAPC4_ENST00000510092.1_Silent_p.L672L	NM_013367.2	NP_037499.2	Q9UJX5	APC4_HUMAN	anaphase promoting complex subunit 4	671					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				CCAGCTGCCTTTGTCTTTAGT	0.358													16	43					0	0	1	0	0	C	25418156	T	C	25418156	2	2	48	1	0	0	0	0	0	0	0	1	600	1838	64	4		4	ANAPC4	4	25418156	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1602541	25418156	165736120	1161	5555										
CCKAR	886	broad.mit.edu	37	chr4	26483533	26483533	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctctgcggaggcggtgtcGtaggcccgccaggcgttggc	18	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:26483533G>A	ENST00000295589.3	-	5	1208	c.1014C>T	c.(1012-1014)taC>taT	p.Y338Y		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	338					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity	p.Y338Y(1)		NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	AGGCGGTGTCGTAGGCCCGCC	0.597													32	73					0	0	1	0	0	A	26483533	G	A	26483533	2	1	48	1	0	0	0	0	0	0	0	1	2900	1140	40	1		1	CCKAR	4	26483533	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1065377	26483533	164670743	1162	5556										
CCKAR	886	broad.mit.edu	37	chr4	26487334	26487334	+	Missense_Mutation	SNP	G	G	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggttgttatttttggtaaaaGgcaccaagttgctataaatg							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:26487334G>T	ENST00000295589.3	-	3	745	c.551C>A	c.(550-552)cCt>cAt	p.P184H		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	184					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	TTTGGTAAAAGGCACCAAGTT	0.433													20	31					2.4624e-09	2.95225e-09	1	1	0	T	26487334	G	T	26487334	3	4	48	1	0	0	0	0	1	0	0	0	2900	1000	35	5	747	5	CCKAR	4	26487334	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3801	26487334	164666942	1163	5557	18	2								
CCKAR	886	broad.mit.edu	37	chr4	26487340	26487340	+	Missense_Mutation	SNP	A	A	G													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttttggtaaaaggcaccAagttgctataaatggggtac							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:26487340A>G	ENST00000295589.3	-	3	739	c.545T>C	c.(544-546)tTg>tCg	p.L182S		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	182					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	AAAAGGCACCAAGTTGCTATA	0.458													16	34					0	0	1	0	0	G	26487340	A	G	26487340	3	3	48	1	0	0	0	0	1	0	0	0	2900	131	5	4	753	4	CCKAR	4	26487340	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6	26487340	164666936	1164	5558	18	2								
STIM2	57620	broad.mit.edu	37	chr4	27003939	27003939	+	Missense_Mutation	SNP	A	A	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgcagaataagacatcaaaAgaacatgttgcaaaaatgat							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:27003939A>T	ENST00000382009.3	+	6	1254	c.987A>T	c.(985-987)aaA>aaT	p.K329N	STIM2_ENST00000412829.2_Missense_Mutation_p.K329N|STIM2_ENST00000467087.1_Missense_Mutation_p.K242N|STIM2_ENST00000465503.1_Missense_Mutation_p.K242N|STIM2_ENST00000467011.1_Missense_Mutation_p.K242N|STIM2_ENST00000237364.5_Missense_Mutation_p.K329N	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	242					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				AGACATCAAAAGAACATGTTG	0.373													10	25					0	0	1	0	0	T	27003939	A	T	27003939	3	4	48	1	0	0	0	0	1	0	0	0	15339	69	3	4	748	4	STIM2	4	27003939	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	516599	27003939	164150337	1165	5559	19	2								
STIM2	57620	broad.mit.edu	37	chr4	27003940	27003940	+	Nonsense_Mutation	SNP	G	G	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcagaataagacatcaaaaGaacatgttgcaaaaatgatg							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:27003940G>T	ENST00000382009.3	+	6	1255	c.988G>T	c.(988-990)Gaa>Taa	p.E330*	STIM2_ENST00000412829.2_Nonsense_Mutation_p.E330*|STIM2_ENST00000467087.1_Nonsense_Mutation_p.E243*|STIM2_ENST00000465503.1_Nonsense_Mutation_p.E243*|STIM2_ENST00000467011.1_Nonsense_Mutation_p.E243*|STIM2_ENST00000237364.5_Nonsense_Mutation_p.E330*	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	243					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding	p.E330*(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				GACATCAAAAGAACATGTTGC	0.373													16	18					3.45872e-05	3.78815e-05	1	1	0	T	27003940	G	T	27003940	4	4	48	1	0	0	0	0	0	1	0	0	15339	943	33	2	749	2	STIM2	4	27003940	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1	27003940	164150336	1166	5560	19	2								
PGM2	55276	broad.mit.edu	37	chr4	37831647	37831647	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtaataaagaagaactacGaaaatgttttggggcccgaa	11	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:37831647G>A	ENST00000381967.4	+	2	243	c.143G>A	c.(142-144)cGa>cAa	p.R48Q	PGM2_ENST00000537241.1_5'UTR|PGM2_ENST00000544359.1_5'UTR	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	48					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						GAAGAACTACGAAAATGTTTT	0.433													22	27					0	0	1	0	0	A	37831647	G	A	37831647	3	1	48	1	0	0	0	0	1	0	0	0	11845	1058	37	1	149	1	PGM2	4	37831647	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10827707	37831647	153322629	1167	5561										
PGM2	55276	broad.mit.edu	37	chr4	37851855	37851855	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttatctgccatgatcaagAaaccattaagaaattatttg	5	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:37851855A>G	ENST00000381967.4	+	12	1563	c.1463A>G	c.(1462-1464)gAa>gGa	p.E488G	PGM2_ENST00000537241.1_Missense_Mutation_p.E328G	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	488			E -> D (in dbSNP:rs10001580).		glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						CATGATCAAGAAACCATTAAG	0.313													5	15					0	0	1	0	0	G	37851855	A	G	37851855	3	3	48	1	0	0	0	0	1	0	0	0	11845	246	9	4	1509	4	PGM2	4	37851855	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	20208	37851855	153302421	1168	5562										
TBC1D1	23216	broad.mit.edu	37	chr4	38046077	38046077	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaaaacaaagcaaagagatCtttaacagagtctttagaaa	7	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:38046077C>A	ENST00000261439.4	+	9	1863	c.1508C>A	c.(1507-1509)tCt>tAt	p.S503Y	TBC1D1_ENST00000508802.1_Missense_Mutation_p.S503Y	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	503						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCAAAGAGATCTTTAACAGAG	0.368													20	50					1.15919e-05	1.28007e-05	1	1	0	A	38046077	C	A	38046077	3	1	48	1	0	0	0	0	1	0	0	0	15653	913	32	2	1538	2	TBC1D1	4	38046077	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	194222	38046077	153108199	1169	5563										
TLR10	81793	broad.mit.edu	37	chr4	38775278	38775278	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcattcttcacccacagaGaatcatgttcactgtatgaa	5	10	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:38775278G>T	ENST00000308973.4	-	4	2539	c.1934C>A	c.(1933-1935)tCt>tAt	p.S645Y	TLR10_ENST00000361424.2_Missense_Mutation_p.S645Y|TLR10_ENST00000508334.1_Missense_Mutation_p.S645Y|TLR10_ENST00000506111.1_Missense_Mutation_p.S645Y	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	645	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						CACCCACAGAGAATCATGTTC	0.403													16	24					0.000422831	0.000449533	1	1	0	T	38775278	G	T	38775278	3	4	48	1	0	0	0	0	1	0	0	0	16009	942	33	2	505	2	TLR10	4	38775278	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	729201	38775278	152378998	1170	5564										
TLR6	10333	broad.mit.edu	37	chr4	38829644	38829644	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccaggaaggtcagttaaaGaattgaaagcaacattgagt	10	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:38829644G>T	ENST00000436693.2	-	2	1570	c.1451C>A	c.(1450-1452)tCt>tAt	p.S484Y	TLR6_ENST00000381950.1_Missense_Mutation_p.S484Y	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	484					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTCAGTTAAAGAATTGAAAGC	0.408													38	55					3.21399e-22	4.46229e-22	1	1	0	T	38829644	G	T	38829644	3	4	48	1	0	0	0	0	1	0	0	0	16014	942	33	2	943	2	TLR6	4	38829644	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	54366	38829644	152324632	1171	5565										
TLR6	10333	broad.mit.edu	37	chr4	38829734	38829734	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgctgtgaagatcaagtAccttgatcctgggaggtaaa	11	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:38829734A>G	ENST00000436693.2	-	2	1480	c.1361T>C	c.(1360-1362)gTa>gCa	p.V454A	TLR6_ENST00000381950.1_Missense_Mutation_p.V454A	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	454					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAGATCAAGTACCTTGATCCT	0.363													38	56					0	0	1	0	0	G	38829734	A	G	38829734	3	3	48	1	0	0	0	0	1	0	0	0	16014	391	14	4	1033	4	TLR6	4	38829734	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	90	38829734	152324542	1172	5566										
RFC1	5981	broad.mit.edu	37	chr4	39313115	39313115	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcttgcctggcatagtccGaatcagattcaacaggccat	8	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:39313115G>A	ENST00000381897.1	-	12	1571	c.1438C>T	c.(1438-1440)Cgg>Tgg	p.R480W	RFC1_ENST00000349703.2_Missense_Mutation_p.R480W	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	480	BRCT.				DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						GGCATAGTCCGAATCAGATTC	0.363													15	19					0	0	1	0	0	A	39313115	G	A	39313115	3	1	48	1	0	0	0	0	1	0	0	0	13295	1057	37	1	2061	1	RFC1	4	39313115	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	483381	39313115	151841161	1173	5567										
LIMCH1	22998	broad.mit.edu	37	chr4	41621302	41621302	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggacttcccatggtgagccGaaatcagcagtgccttttaa	10	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:41621302G>A	ENST00000313860.7	+	8	834	c.780G>A	c.(778-780)ccG>ccA	p.P260P	LIMCH1_ENST00000503057.1_Silent_p.P101P|LIMCH1_ENST00000509277.1_Silent_p.P106P|LIMCH1_ENST00000514096.1_Silent_p.P113P|LIMCH1_ENST00000396595.3_Silent_p.P106P|LIMCH1_ENST00000508501.1_Silent_p.P260P|LIMCH1_ENST00000509638.1_Silent_p.P101P|LIMCH1_ENST00000381753.4_Silent_p.P106P|LIMCH1_ENST00000513024.1_Silent_p.P101P|LIMCH1_ENST00000509454.1_Silent_p.P108P|LIMCH1_ENST00000512632.1_Silent_p.P260P|LIMCH1_ENST00000511496.1_Silent_p.P101P|LIMCH1_ENST00000512946.1_Silent_p.P260P|LIMCH1_ENST00000512820.1_Silent_p.P260P	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	260					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						ATGGTGAGCCGAAATCAGCAG	0.532													97	148					0	0	1	0	0	A	41621302	G	A	41621302	2	1	48	1	0	0	0	0	0	0	0	1	8836	1045	37	1		1	LIMCH1	4	41621302	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2308187	41621302	149532974	1174	5568										
LIMCH1	22998	broad.mit.edu	37	chr4	41691559	41691559	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctaggtctataagtggaaaGaagctgtgctcttcctgtgg	12	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:41691559G>T	ENST00000313860.7	+	25	3084	c.3030G>T	c.(3028-3030)aaG>aaT	p.K1010N	LIMCH1_ENST00000503057.1_Missense_Mutation_p.K1394N|LIMCH1_ENST00000509277.1_Missense_Mutation_p.K843N|LIMCH1_ENST00000514096.1_Missense_Mutation_p.K824N|LIMCH1_ENST00000396595.3_Missense_Mutation_p.K829N|LIMCH1_ENST00000508501.1_Missense_Mutation_p.K983N|LIMCH1_ENST00000381753.4_Missense_Mutation_p.K817N|LIMCH1_ENST00000513024.1_Missense_Mutation_p.K837N|LIMCH1_ENST00000512632.1_Missense_Mutation_p.K907N|LIMCH1_ENST00000511496.1_Missense_Mutation_p.K824N|LIMCH1_ENST00000512946.1_Missense_Mutation_p.K984N|RP11-227F19.5_ENST00000506475.1_RNA|LIMCH1_ENST00000512820.1_Missense_Mutation_p.K996N	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	1010					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TAAGTGGAAAGAAGCTGTGCT	0.388													6	26					0.0215528	0.0219788	1	1	0	T	41691559	G	T	41691559	3	4	48	1	0	0	0	0	1	0	0	0	8836	933	33	2	3156	2	LIMCH1	4	41691559	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	70257	41691559	149462717	1175	5569										
DCAF4L1	285429	broad.mit.edu	37	chr4	41984734	41984734	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaaatgtgtaaggcagtacGaaggtcacgtgaatgagtcc	12	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:41984734G>A	ENST00000333141.5	+	1	1022	c.925G>A	c.(925-927)Gaa>Aaa	p.E309K		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	309										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						AAGGCAGTACGAAGGTCACGT	0.532													40	81					0	0	1	0	0	A	41984734	G	A	41984734	3	1	48	1	0	0	0	0	1	0	0	0	4295	1059	37	1	927	1	DCAF4L1	4	41984734	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	293175	41984734	149169542	1176	5570										
SLC30A9	10463	broad.mit.edu	37	chr4	42024887	42024887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttcgaaaaatcagacgacGaagtccccatgaagatactg	8	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:42024887G>A	ENST00000264451.6	+	5	647	c.467G>A	c.(466-468)cGa>cAa	p.R156Q		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	156					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATCAGACGACGAAGTCCCCAT	0.328													15	25					0	0	1	0	0	A	42024887	G	A	42024887	3	1	48	1	0	0	0	0	1	0	0	0	14616	1058	37	1	485	1	SLC30A9	4	42024887	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40153	42024887	149129389	1177	5571										
GRXCR1	389207	broad.mit.edu	37	chr4	43032511	43032511	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagccctgaagtgtacggCttgcaatgaaaatggtcttc	10	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:43032511C>T	ENST00000399770.2	+	4	827	c.827C>T	c.(826-828)gCt>gTt	p.A276V		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	276					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						AAGTGTACGGCTTGCAATGAA	0.443													49	73					0	0	1	0	0	T	43032511	C	T	43032511	3	4	48	1	0	0	0	0	1	0	0	0	6852	797	28	3	841	3	GRXCR1	4	43032511	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1007624	43032511	148121765	1178	5572										
KCTD8	386617	broad.mit.edu	37	chr4	44176933	44176933	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcttccacacttagcttCtcacagactttctttttgga	4	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:44176933C>T	ENST00000360029.3	-	2	1579	c.1296G>A	c.(1294-1296)gaG>gaA	p.E432E		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	432						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CACTTAGCTTCTCACAGACTT	0.413										HNSCC(17;0.042)			71	125					0	0	1	0	0	T	44176933	C	T	44176933	2	4	48	1	0	0	0	0	0	0	0	1	8158	912	32	3		3	KCTD8	4	44176933	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1144422	44176933	146977343	1179	5573										
GABRA4	2557	broad.mit.edu	37	chr4	46995427	46995427	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagcgatcgcgggtaccttCttggcagaaaccatctttgc	11	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:46995427C>A	ENST00000264318.3	-	1	997	c.15G>T	c.(13-15)aaG>aaT	p.K5N	GABRA4_ENST00000509316.1_5'UTR	NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	5					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CGGGTACCTTCTTGGCAGAAA	0.602													28	50					9.39395e-14	1.21013e-13	1	1	0	A	46995427	C	A	46995427	3	1	48	1	0	0	0	0	1	0	0	0	6197	912	32	2	1685	2	GABRA4	4	46995427	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2818494	46995427	144158849	1180	5574										
CORIN	10699	broad.mit.edu	37	chr4	47655594	47655594	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttcctcatcactgtcatCgtcacagtcggcctggccat	8	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:47655594C>T	ENST00000273857.4	-	13	1818	c.1819G>A	c.(1819-1821)Gat>Aat	p.D607N	CORIN_ENST00000508498.1_Missense_Mutation_p.D468N|CORIN_ENST00000504584.1_Missense_Mutation_p.D570N|CORIN_ENST00000505909.1_Missense_Mutation_p.D570N|CORIN_ENST00000502252.1_Missense_Mutation_p.D540N	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	607	LDL-receptor class A 5.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TCACTGTCATCGTCACAGTCG	0.393													4	53					0	0	1	0	0	T	47655594	C	T	47655594	3	4	48	1	0	0	0	0	1	0	0	0	3775	884	31	1	1349	1	CORIN	4	47655594	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	660167	47655594	143498682	1181	5575										
CNGA1	1259	broad.mit.edu	37	chr4	47939204	47939204	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccacaggtagtcaaaccatTtaataaccctcttttccata	3	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:47939204T>G	ENST00000402813.3	-	10	1656	c.1514A>C	c.(1513-1515)aAa>aCa	p.K505T	CNGA1_ENST00000514170.1_Missense_Mutation_p.K436T|CNGA1_ENST00000544810.1_Missense_Mutation_p.K436T|CNGA1_ENST00000420489.2_Missense_Mutation_p.K436T|CNGA1_ENST00000358519.4_Missense_Mutation_p.K436T			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	436					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						GTCAAACCATTTAATAACCCT	0.348													9	82					0	0	1	0	0	G	47939204	T	G	47939204	3	3	48	1	0	0	0	0	1	0	0	0	3619	1841	64	4	769	4	CNGA1	4	47939204	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	283610	47939204	143215072	1182	5576										
TEC	7006	broad.mit.edu	37	chr4	48139468	48139468	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttcacattcaactagttCatctattgtgcgcagcagat	6	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:48139468C>A	ENST00000381501.3	-	18	2018	c.1861G>T	c.(1861-1863)Gaa>Taa	p.E621*		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	621	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						TCAACTAGTTCATCTATTGTG	0.433													18	25					9.16793e-09	1.08598e-08	1	1	0	A	48139468	C	A	48139468	4	1	48	1	0	0	0	0	0	1	0	0	15800	835	29	2	38	2	TEC	4	48139468	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	200264	48139468	143014808	1183	5577										
TEC	7006	broad.mit.edu	37	chr4	48178116	48178116	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacctgaaatggatacttatTttgacagggaatgacaccat	8	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:48178116T>G	ENST00000381501.3	-	3	383	c.226A>C	c.(226-228)Aat>Cat	p.N76H		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	76	PH.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						GGATACTTATTTTGACAGGGA	0.378													19	37					0	0	1	0	0	G	48178116	T	G	48178116	3	3	48	1	0	0	0	0	1	0	0	0	15800	1841	64	4	1733	4	TEC	4	48178116	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	38648	48178116	142976160	1184	5578										
SPATA18	132671	broad.mit.edu	37	chr4	52948557	52948557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtatattgaaaacagatacCgccgcagctacgactcggat	9	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:52948557C>T	ENST00000295213.4	+	10	1734	c.1360C>T	c.(1360-1362)Cgc>Tgc	p.R454C	SPATA18_ENST00000419395.2_Missense_Mutation_p.R422C	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	454					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AAACAGATACCGCCGCAGCTA	0.413													22	63					0	0	1	0	0	T	52948557	C	T	52948557	3	4	48	1	0	0	0	0	1	0	0	0	15058	652	23	1	1398	1	SPATA18	4	52948557	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4770441	52948557	138205719	1185	5579										
GSX2	170825	broad.mit.edu	37	chr4	54967832	54967832	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactcctggagctggagagaGaattctcttccaacatgtac	9	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:54967832G>T	ENST00000326902.2	+	2	972	c.658G>T	c.(658-660)Gaa>Taa	p.E220*	FIP1L1_ENST00000507166.1_Intron|GSX2_ENST00000548609.1_3'UTR|GSX2_ENST00000503800.1_3'UTR	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	220						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			GCTGGAGAGAGAATTCTCTTC	0.552													26	116					8.24728e-16	1.09065e-15	1	1	0	T	54967832	G	T	54967832	4	4	48	1	0	0	0	0	0	1	0	0	6890	943	33	2	664	2	GSX2	4	54967832	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2019275	54967832	136186444	1186	5580										
KIT	3815	broad.mit.edu	37	chr4	55561832	55561832	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgagatcctggatgaaacGaatgagaataagcagaatga	11	4	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:55561832G>A	ENST00000288135.5	+	2	319	c.222G>A	c.(220-222)acG>acA	p.T74T		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	74	Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.T74T(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGGATGAAACGAATGAGAATA	0.458		1	"Mis, O"		"GIST, AML, TGCT, mastocytosis, mucosal melanoma"	"GIST, epithelioma"	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				26	35					0	0	1	0	0	A	55561832	G	A	55561832	2	1	48	1	0	0	0	0	0	0	0	1	8371	1045	37	1		1	KIT	4	55561832	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	594000	55561832	135592444	1187	5581										
KIT	3815	broad.mit.edu	37	chr4	55594177	55594177	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcatgtttccaattttagCgagtgcccatttgacagaac	8	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:55594177C>T	ENST00000288135.5	+	13	1977	c.1879_splice	c.e13-1	p.P627_splice		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	627	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.P627L(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCAATTTTAGCGAGTGCCCAT	0.433		1	"Mis, O"		"GIST, AML, TGCT, mastocytosis, mucosal melanoma"	"GIST, epithelioma"	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				23	48					0	0	1	0	0	T	55594177	C	T	55594177	5	4	48	1	0	0	0	0	0	0	1	0	8371	782	27	1	1930	1	KIT	4	55594177	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32345	55594177	135560099	1188	5582										
KIT	3815	broad.mit.edu	37	chr4	55602731	55602731	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtatacacgtttgaaagtgAcgtctggtcctatgggattt	11	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:55602731A>G	ENST00000288135.5	+	18	2649	c.2552A>G	c.(2551-2553)gAc>gGc	p.D851G		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	851	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TTTGAAAGTGACGTCTGGTCC	0.408		1	"Mis, O"		"GIST, AML, TGCT, mastocytosis, mucosal melanoma"	"GIST, epithelioma"	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				29	72					0	0	1	0	0	G	55602731	A	G	55602731	3	3	48	1	0	0	0	0	1	0	0	0	8371	275	10	4	2622	4	KIT	4	55602731	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	8554	55602731	135551545	1189	5583										
KDR	3791	broad.mit.edu	37	chr4	55946184	55946184	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctaccggtttgcactccaAtctctatcagctttaaaagt	6	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:55946184A>C	ENST00000263923.4	-	30	4290	c.3995T>G	c.(3994-3996)aTt>aGt	p.I1332S	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1332					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTGCACTCCAATCTCTATCAG	0.522			Mis		"NSCLC, angiosarcoma"					TSP Lung(20;0.16)			44	82					0	0	1	0	0	C	55946184	A	C	55946184	3	2	48	1	0	0	0	0	1	0	0	0	8181	101	4	4	79	4	KDR	4	55946184	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	343453	55946184	135208092	1190	5584										
KDR	3791	broad.mit.edu	37	chr4	55968605	55968605	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcccagatgccgtgcatgaGacttcgatgctttccccaat	8	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:55968605G>T	ENST00000263923.4	-	14	2353	c.2058C>A	c.(2056-2058)gtC>gtA	p.V686V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	686	Ig-like C2-type 7.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCGTGCATGAGACTTCGATGC	0.453			Mis		"NSCLC, angiosarcoma"					TSP Lung(20;0.16)			28	64					9.22233e-05	9.98021e-05	1	1	0	T	55968605	G	T	55968605	2	4	48	1	0	0	0	0	0	0	0	1	8181	929	33	2		2	KDR	4	55968605	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	22421	55968605	135185671	1191	5585										
SRD5A3	79644	broad.mit.edu	37	chr4	56230296	56230296	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatttctgtggctgcacagCttacgaagactcttcgagtg	11	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:56230296C>T	ENST00000264228.4	+	3	648	c.420C>T	c.(418-420)agC>agT	p.S140S	SRD5A3_ENST00000514398.1_3'UTR|SRD5A3-AS1_ENST00000433175.2_RNA	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	140					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GGCTGCACAGCTTACGAAGAC	0.468													42	77					0	0	1	0	0	T	56230296	C	T	56230296	2	4	48	1	0	0	0	0	0	0	0	1	15195	796	28	3		3	SRD5A3	4	56230296	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	261691	56230296	134923980	1192	5586										
SRD5A3	79644	broad.mit.edu	37	chr4	56233805	56233805	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcacggtggttccatattCttgggatgatgatgttcatc	11	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:56233805C>A	ENST00000264228.4	+	4	841	c.613C>A	c.(613-615)Ctt>Att	p.L205I	SRD5A3-AS1_ENST00000510637.1_RNA|SRD5A3-AS1_ENST00000595103.1_RNA|SRD5A3_ENST00000514398.1_Intron|SRD5A3-AS1_ENST00000596289.1_RNA|SRD5A3-AS1_ENST00000596312.1_RNA|SRD5A3-AS1_ENST00000598906.1_RNA|SRD5A3-AS1_ENST00000595734.1_RNA|SRD5A3-AS1_ENST00000433175.2_RNA	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	205					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GTTCCATATTCTTGGGATGAT	0.408													23	42					2.21704e-12	2.79328e-12	1	1	0	A	56233805	C	A	56233805	3	1	48	1	0	0	0	0	1	0	0	0	15195	913	32	2	627	2	SRD5A3	4	56233805	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3509	56233805	134920471	1193	5587										
EXOC1	55763	broad.mit.edu	37	chr4	56730415	56730415	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatcctgaatttgatttacActttgaaaaaatatataaat	3	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:56730415A>G	ENST00000381295.2	+	4	626	c.278A>G	c.(277-279)cAc>cGc	p.H93R	EXOC1_ENST00000346134.7_Missense_Mutation_p.H93R|EXOC1_ENST00000349598.6_Missense_Mutation_p.H93R	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	93					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					TTTGATTTACACTTTGAAAAA	0.289													7	7					0	0	1	0	0	G	56730415	A	G	56730415	3	3	48	1	0	0	0	0	1	0	0	0	5328	159	6	4	288	4	EXOC1	4	56730415	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	496610	56730415	134423861	1194	5588										
EXOC1	55763	broad.mit.edu	37	chr4	56738059	56738059	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacagcaacagcagcgattcAgtgatttgcgagagcttttt	10	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:56738059A>G	ENST00000381295.2	+	8	1357	c.1009A>G	c.(1009-1011)Agt>Ggt	p.S337G	EXOC1_ENST00000346134.7_Missense_Mutation_p.S337G|EXOC1_ENST00000349598.6_Missense_Mutation_p.S337G	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	337					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					GCAGCGATTCAGTGATTTGCG	0.413													25	45					0	0	1	0	0	G	56738059	A	G	56738059	3	3	48	1	0	0	0	0	1	0	0	0	5328	188	7	4	1035	4	EXOC1	4	56738059	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7644	56738059	134416217	1195	5589										
CEP135	9662	broad.mit.edu	37	chr4	56878113	56878113	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acactgagaggagacatcttCgagaaagagtggagctatta	12	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:56878113C>T	ENST00000257287.4	+	21	2888	c.2764C>T	c.(2764-2766)Cga>Tga	p.R922*		NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	922					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					GAGACATCTTCGAGAAAGAGT	0.383													16	42					0	0	1	0	0	T	56878113	C	T	56878113	4	4	48	1	0	0	0	0	0	1	0	0	3269	876	31	1	2842	1	CEP135	4	56878113	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140054	56878113	134276163	1196	5590										
KIAA1211	57482	broad.mit.edu	37	chr4	57180406	57180406	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggaagcagccgagaagagAcgcctagaggagcagaggct	17	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:57180406A>G	ENST00000504228.1	+	6	843	c.738A>G	c.(736-738)agA>agG	p.R246R	KIAA1211_ENST00000264229.6_Silent_p.R246R|KIAA1211_ENST00000541073.1_Silent_p.R239R			Q6ZU35	K1211_HUMAN	KIAA1211	246	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CCGAGAAGAGACGCCTAGAGG	0.612													8	14					0	0	1	0	0	G	57180406	A	G	57180406	2	3	48	1	0	0	0	0	0	0	0	1	8256	272	10	4		4	KIAA1211	4	57180406	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	302293	57180406	133973870	1197	5591										
KIAA1211	57482	broad.mit.edu	37	chr4	57181891	57181891	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctccaaacagagcacggaAgctgaaagcatacgaaaaag	9	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:57181891A>C	ENST00000504228.1	+	6	2328	c.2223A>C	c.(2221-2223)gaA>gaC	p.E741D	KIAA1211_ENST00000264229.6_Missense_Mutation_p.E741D|KIAA1211_ENST00000541073.1_Missense_Mutation_p.E734D			Q6ZU35	K1211_HUMAN	KIAA1211	741										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AGAGCACGGAAGCTGAAAGCA	0.567													37	75					0	0	1	0	0	C	57181891	A	C	57181891	3	2	48	1	0	0	0	0	1	0	0	0	8256	69	3	4	2241	4	KIAA1211	4	57181891	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1485	57181891	133972385	1198	5592										
REST	5978	broad.mit.edu	37	chr4	57797479	57797479	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagcctcctctccgaaaaGataaaaaggaaaagtctaac	6	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:57797479G>T	ENST00000309042.7	+	4	2769	c.2455G>T	c.(2455-2457)Gat>Tat	p.D819Y		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	819					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					TCTCCGAAAAGATAAAAAGGA	0.498													77	117					1.52378e-38	2.19585e-38	1	1	0	T	57797479	G	T	57797479	3	4	48	1	0	0	0	0	1	0	0	0	13285	942	33	2	2465	2	REST	4	57797479	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	615588	57797479	133356797	1199	5593										
POLR2B	5431	broad.mit.edu	37	chr4	57883789	57883789	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggagtttacatcaccaacTtccatgttcgcatggacaca	8	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:57883789T>G	ENST00000381227.1	+	17	2631	c.2218T>G	c.(2218-2220)Ttc>Gtc	p.F740V	POLR2B_ENST00000314595.5_Missense_Mutation_p.F740V|POLR2B_ENST00000431623.2_Missense_Mutation_p.F665V|POLR2B_ENST00000441246.2_Missense_Mutation_p.F733V			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	740					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					CATCACCAACTTCCATGTTCG	0.423													5	15					0	0	1	0	0	G	57883789	T	G	57883789	3	3	48	1	0	0	0	0	1	0	0	0	12262	1609	56	4	2280	4	POLR2B	4	57883789	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	86310	57883789	133270487	1200	5594										
EPHA5	2044	broad.mit.edu	37	chr4	66201816	66201816	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccatggggcttggcagacGatagccttcctctaccgctt	10	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:66201816G>A	ENST00000273854.3	-	16	3286	c.2686C>T	c.(2686-2688)Cgt>Tgt	p.R896C	EPHA5_ENST00000354839.4_Missense_Mutation_p.R874C|EPHA5_ENST00000432638.2_Missense_Mutation_p.R733C|EPHA5_ENST00000511294.1_Missense_Mutation_p.R897C	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	896	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTTGGCAGACGATAGCCTTCC	0.438										TSP Lung(17;0.13)			12	29					0	0	1	0	0	A	66201816	G	A	66201816	3	1	48	1	0	0	0	0	1	0	0	0	5198	1058	37	1	439	1	EPHA5	4	66201816	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8318027	66201816	124952460	1201	5595										
EPHA5	2044	broad.mit.edu	37	chr4	66361152	66361152	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactctctcctgaaataatcCttttcacagacacaagaggt	6	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:66361152C>A	ENST00000273854.3	-	4	1620	c.1020G>T	c.(1018-1020)aaG>aaT	p.K340N	EPHA5_ENST00000354839.4_Missense_Mutation_p.K340N|EPHA5_ENST00000432638.2_Intron|EPHA5_ENST00000511294.1_Missense_Mutation_p.K340N	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	340	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGAAATAATCCTTTTCACAGA	0.463										TSP Lung(17;0.13)			45	80					8.48111e-28	1.20306e-27	1	1	0	A	66361152	C	A	66361152	3	1	48	1	0	0	0	0	1	0	0	0	5198	680	24	5	2153	5	EPHA5	4	66361152	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	159336	66361152	124793124	1202	5596										
UBA6	55236	broad.mit.edu	37	chr4	68530925	68530925	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaaaaaaactgttttaggAgtcttaacttggacagctat	7	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:68530925A>G	ENST00000322244.4	-	10	938	c.879T>C	c.(877-879)acT>acC	p.T293T	UBA6_ENST00000420827.2_Silent_p.T293T	NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	293					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						CTGTTTTAGGAGTCTTAACTT	0.323													4	54					0	0	1	0	0	G	68530925	A	G	68530925	2	3	48	1	0	0	0	0	0	0	0	1	16892	291	11	4		4	UBA6	4	68530925	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2169773	68530925	122623351	1203	5597										
UGT2B15	7366	broad.mit.edu	37	chr4	69535816	69535816	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtgtagccaacagagaatCgaagactgtacagaaagggt	12	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:69535816C>T	ENST00000338206.5	-	1	530	c.521G>A	c.(520-522)cGa>cAa	p.R174Q		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	174				LYSLRFSV -> VYRSRISR (in Ref. 6; AAA83406).	steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										AACAGAGAATCGAAGACTGTA	0.408													14	205					0	0	1	0	0	T	69535816	C	T	69535816	3	4	48	1	0	0	0	0	1	0	0	0	17017	884	31	1	2712	1	UGT2B15	4	69535816	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1004891	69535816	121618460	1204	5598										
UGT2B15	7366	broad.mit.edu	37	chr4	69536087	69536087	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagaatcttccaaataatTtttagttaaagatgtaggat	7	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:69536087T>G	ENST00000338206.5	-	1	259	c.250A>C	c.(250-252)Aat>Cat	p.N84H		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	84					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										TCCAAATAATTTTTAGTTAAA	0.308													52	74					0	0	1	0	0	G	69536087	T	G	69536087	3	3	48	1	0	0	0	0	1	0	0	0	17017	1841	64	4	2983	4	UGT2B15	4	69536087	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	271	69536087	121618189	1205	5599										
UGT2B10	7365	broad.mit.edu	37	chr4	69693266	69693266	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacagtaattaatgatccttCgtgagtagaacaatattttt	7	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:69693266C>T	ENST00000265403.7	+	5	1334	c.1307_splice	c.e5+1	p.S436_splice	UGT2B10_ENST00000458688.2_Splice_Site_p.S352_splice	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	436					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						AATGATCCTTCGTGAGTAGAA	0.388													40	79					0	0	1	0	0	T	69693266	C	T	69693266	5	4	48	1	0	0	0	0	0	0	1	0	17015	898	31	1	1325	1	UGT2B10	4	69693266	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	157179	69693266	121461010	1206	5600										
UGT2B11	10720	broad.mit.edu	37	chr4	70080254	70080254	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcatcattgggatcaaaaaGaatggaagctgaagatgcca	11	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:70080254G>T	ENST00000446444.1	-	1	195	c.187C>A	c.(187-189)Ctt>Att	p.L63I	RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	63					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GGATCAAAAAGAATGGAAGCT	0.388													28	145					4.74835e-14	6.14782e-14	1	1	0	T	70080254	G	T	70080254	3	4	48	1	0	0	0	0	1	0	0	0	17016	942	33	2	1426	2	UGT2B11	4	70080254	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	386988	70080254	121074022	1207	5601										
UGT2B4	7363	broad.mit.edu	37	chr4	70346621	70346621	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgataatttcatagcattctCtttatatctaaacgataagc	4	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:70346621C>A	ENST00000305107.6	-	6	1364	c.1318G>T	c.(1318-1320)Gag>Tag	p.E440*	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_Missense_Mutation_p.K366N|UGT2B4_ENST00000381096.3_Nonsense_Mutation_p.E304*	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	440					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						ATAGCATTCTCTTTATATCTA	0.418													30	74					5.45727e-16	7.22369e-16	1	1	0	A	70346621	C	A	70346621	4	1	48	1	0	0	0	0	0	1	0	0	17020	922	32	2	272	2	UGT2B4	4	70346621	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	266367	70346621	120807655	1208	5602										
AMBN	258	broad.mit.edu	37	chr4	71472354	71472354	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagcaaccatggataccacGatggccccaaactctctgca	8	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:71472354G>A	ENST00000322937.6	+	13	1354	c.1251G>A	c.(1249-1251)acG>acA	p.T417T	AMBN_ENST00000449493.2_Silent_p.T402T	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	417					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			TGGATACCACGATGGCCCCAA	0.512													38	70					0	0	1	0	0	A	71472354	G	A	71472354	2	1	48	1	0	0	0	0	0	0	0	1	559	1045	37	1		1	AMBN	4	71472354	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1125733	71472354	119681922	1209	5603										
ENAM	10117	broad.mit.edu	37	chr4	71507979	71507979	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtaccccaggactaaacaCtgggaacaaccctccagctc	7	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:71507979C>T	ENST00000396073.3	+	9	1117	c.836C>T	c.(835-837)aCt>aTt	p.T279I	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	279					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			GGACTAAACACTGGGAACAAC	0.532													11	75					0	0	1	0	0	T	71507979	C	T	71507979	3	4	48	1	0	0	0	0	1	0	0	0	5140	565	20	3	866	3	ENAM	4	71507979	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	35625	71507979	119646297	1210	5604										
GC	2638	broad.mit.edu	37	chr4	72631284	72631284	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgttccaggccctctttgGtgcagcactcagcagtgcct	10	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:72631284G>T	ENST00000273951.8	-	4	681	c.338C>A	c.(337-339)aCc>aAc	p.T113N	GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Missense_Mutation_p.T132N|GC_ENST00000513476.1_Missense_Mutation_p.T113N	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	113	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GCCCTCTTTGGTGCAGCACTC	0.517													29	64					1.17739e-12	1.49076e-12	1	1	0	T	72631284	G	T	72631284	3	4	48	1	0	0	0	0	1	0	0	0	6321	1261	44	5	1122	5	GC	4	72631284	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1123305	72631284	118522992	1211	5605										
ADAMTS3	9508	broad.mit.edu	37	chr4	73161417	73161417	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacattcgtctaataggttTcggctttttgttggcctcac	9	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:73161417T>C	ENST00000286657.4	-	19	2713	c.2677A>G	c.(2677-2679)Aaa>Gaa	p.K893E		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	893	TSP type-1 2.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTAATAGGTTTCGGCTTTTTG	0.393													8	51					0	0	1	0	0	C	73161417	T	C	73161417	3	2	48	1	0	0	0	0	1	0	0	0	266	1792	62	4	956	4	ADAMTS3	4	73161417	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	530133	73161417	117992859	1212	5606										
ADAMTS3	9508	broad.mit.edu	37	chr4	73188757	73188757	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatcccagcattatcatgcGcaccaggaccacatttatat	5	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:73188757G>A	ENST00000286657.4	-	6	955	c.919C>T	c.(919-921)Cgc>Tgc	p.R307C	RP11-373J21.1_ENST00000503918.1_RNA	NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	307	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATTATCATGCGCACCAGGACC	0.363													43	89					0	0	1	0	0	A	73188757	G	A	73188757	3	1	48	1	0	0	0	0	1	0	0	0	266	1087	38	1	2766	1	ADAMTS3	4	73188757	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	27340	73188757	117965519	1213	5607										
ALB	213	broad.mit.edu	37	chr4	74283943	74283943	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtcgatgaaacatacgttCccaaagagtttaatgctgaa	8	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:74283943C>T	ENST00000295897.4	+	12	1656	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S	ALB_ENST00000415165.2_Missense_Mutation_p.P331S|ALB_ENST00000509063.1_Missense_Mutation_p.P523S|ALB_ENST00000503124.1_Missense_Mutation_p.P373S|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000401494.3_Missense_Mutation_p.P408S	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	523	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AACATACGTTCCCAAAGAGTT	0.428													21	38					0	0	1	0	0	T	74283943	C	T	74283943	3	4	48	1	0	0	0	0	1	0	0	0	483	855	30	3	1613	3	ALB	4	74283943	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1095186	74283943	116870333	1214	5608										
PARM1	25849	broad.mit.edu	37	chr4	75971446	75971446	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actacaacaaccctctgtacGatgactcctaacaatggaat	5	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:75971446G>T	ENST00000307428.7	+	4	1134	c.922G>T	c.(922-924)Gat>Tat	p.D308Y	PARM1_ENST00000513238.1_Missense_Mutation_p.D66Y	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	308					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CCCTCTGTACGATGACTCCTA	0.438													12	19					2.61681e-11	3.25035e-11	1	1	0	T	75971446	G	T	75971446	3	4	48	1	0	0	0	0	1	0	0	0	11498	1058	37	2	936	2	PARM1	4	75971446	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1687503	75971446	115182830	1215	5609										
NUP54	53371	broad.mit.edu	37	chr4	77036593	77036593	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctttatatcttctagatCgtctttaatgatgctaatca	5	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:77036593C>A	ENST00000264883.3	-	12	1590	c.1450G>T	c.(1450-1452)Gat>Tat	p.D484Y	NUP54_ENST00000514987.1_Missense_Mutation_p.D436Y|NUP54_ENST00000458189.2_Missense_Mutation_p.D304Y|NUP54_ENST00000342467.6_Missense_Mutation_p.D268Y	NM_017426.2	NP_059122.2	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	484					carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm		p.D484Y(1)		cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(3)|skin(1)|stomach(1)	19						TCTTCTAGATCGTCTTTAATG	0.333													4	27					0.150653	0.151842	1	1	0	A	77036593	C	A	77036593	3	1	48	1	0	0	0	0	1	0	0	0	10814	884	31	2	77	2	NUP54	4	77036593	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1065147	77036593	114117683	1216	5610										
NUP54	53371	broad.mit.edu	37	chr4	77053689	77053689	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacataccagcaggaggattCtgtaaaagctgtttgatctg	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:77053689C>T	ENST00000264883.3	-	6	1034	c.894G>A	c.(892-894)caG>caA	p.Q298Q	NUP54_ENST00000514987.1_Silent_p.Q250Q|NUP54_ENST00000458189.2_Silent_p.Q118Q|NUP54_ENST00000342467.6_Silent_p.Q118Q	NM_017426.2	NP_059122.2	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	298	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(3)|skin(1)|stomach(1)	19						CAGGAGGATTCTGTAAAAGCT	0.368													49	70					0	0	1	0	0	T	77053689	C	T	77053689	2	4	48	1	0	0	0	0	0	0	0	1	10814	912	32	3		3	NUP54	4	77053689	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17096	77053689	114100587	1217	5611										
SHROOM3	57619	broad.mit.edu	37	chr4	77700186	77700186	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagctgggccaggagcaggtCaagtgtctgctggagagcct	16	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:77700186C>A	ENST00000296043.6	+	11	6800	c.5847C>A	c.(5845-5847)gtC>gtA	p.V1949V	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1949	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			AGGAGCAGGTCAAGTGTCTGC	0.582													44	93					2.01872e-29	2.87446e-29	1	1	0	A	77700186	C	A	77700186	2	1	48	1	0	0	0	0	0	0	0	1	14349	813	29	2		2	SHROOM3	4	77700186	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	646497	77700186	113454090	1218	5612										
CCNI	10983	broad.mit.edu	37	chr4	77969638	77969638	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcttgctgttgtccttggAgaagtctgggcctgggacag	16	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:77969638A>G	ENST00000237654.4	-	7	1444	c.868T>C	c.(868-870)Tcc>Ccc	p.S290P	CCNI_ENST00000537948.1_Missense_Mutation_p.S276P	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	290					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						TTGTCCTTGGAGAAGTCTGGG	0.532													41	60					0	0	1	0	0	G	77969638	A	G	77969638	3	3	48	1	0	0	0	0	1	0	0	0	2948	304	11	4	269	4	CCNI	4	77969638	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	269452	77969638	113184638	1219	5613										
PAQR3	152559	broad.mit.edu	37	chr4	79845024	79845024	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctacctggaaagtaccgCtctgggactttggaaatgta	10	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:79845024C>T	ENST00000512733.1	-	5	993	c.780G>A	c.(778-780)gaG>gaA	p.E260E	PAQR3_ENST00000380645.4_Silent_p.E260E|PAQR3_ENST00000295462.3_3'UTR|PAQR3_ENST00000515541.1_Intron	NM_001040202.1	NP_001035292.1	Q6TCH7	PAQR3_HUMAN	progestin and adipoQ receptor family member III	260						Golgi membrane|integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	8						GAAAGTACCGCTCTGGGACTT	0.368													16	17					0	0	1	0	0	T	79845024	C	T	79845024	2	4	48	1	0	0	0	0	0	0	0	1	11482	796	28	3		3	PAQR3	4	79845024	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1875386	79845024	111309252	1220	5614										
HNRNPD	3184	broad.mit.edu	37	chr4	83280639	83280639	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actaccttatctacactctcCgattctttaaatagcacaaa	2	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:83280639C>T	ENST00000313899.7	-	3	721	c.444G>A	c.(442-444)tcG>tcA	p.S148S	HNRNPD_ENST00000543098.1_Silent_p.S96S|HNRNPD_ENST00000352301.4_Silent_p.S129S|HNRNPD_ENST00000353341.4_Silent_p.S148S|HNRNPD_ENST00000541060.1_Intron	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	148	RRM 1.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						CTACACTCTCCGATTCTTTAA	0.358													23	41					0	0	1	0	0	T	83280639	C	T	83280639	2	4	48	1	0	0	0	0	0	0	0	1	7304	639	23	1		1	HNRNPD	4	83280639	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3435615	83280639	107873637	1221	5615										
THAP9	79725	broad.mit.edu	37	chr4	83839057	83839057	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgacactagcaataatcaAataattaaaggtaagcaaaa	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:83839057A>G	ENST00000302236.5	+	5	1743	c.1692A>G	c.(1690-1692)caA>caG	p.Q564Q	LIN54_ENST00000505905.1_Intron	NM_024672.4	NP_078948.3	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	564							DNA binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(13)|lung(5)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(3)	33		Hepatocellular(203;0.114)				GCAATAATCAAATAATTAAAG	0.348													21	29					0	0	1	0	0	G	83839057	A	G	83839057	2	3	48	1	0	0	0	0	0	0	0	1	15910	11	1	4		4	THAP9	4	83839057	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	558418	83839057	107315219	1222	5616										
WDFY3	23001	broad.mit.edu	37	chr4	85738736	85738736	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctccaaattctcgaaaaaTtccttgaaggaaggagaaaa	7	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:85738736T>G	ENST00000322366.6	-	13	2103	c.1696A>C	c.(1696-1698)Att>Ctt	p.I566L	WDFY3_ENST00000295888.4_Missense_Mutation_p.I566L			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	566						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCTCGAAAAATTCCTTGAAGG	0.378													8	62					0	0	1	0	0	G	85738736	T	G	85738736	3	3	48	1	0	0	0	0	1	0	0	0	17329	1493	52	4	9151	4	WDFY3	4	85738736	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1899679	85738736	105415540	1223	5617										
ARHGAP24	83478	broad.mit.edu	37	chr4	86844806	86844806	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtgttttcacaggaggcGatcgagatcggatgacagca	13	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:86844806G>A	ENST00000395184.1	+	4	740	c.274G>A	c.(274-276)Gat>Aat	p.D92N	ARHGAP24_ENST00000395183.2_5'UTR|ARHGAP24_ENST00000503995.1_Missense_Mutation_p.D92N	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	92	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CACAGGAGGCGATCGAGATCG	0.483													9	23					0	0	1	0	0	A	86844806	G	A	86844806	3	1	48	1	0	0	0	0	1	0	0	0	870	1058	37	1	284	1	ARHGAP24	4	86844806	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1106070	86844806	104309470	1224	5618										
MAPK10	5602	broad.mit.edu	37	chr4	86985420	86985420	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggcagcctatttcttaccGcctccacttcggctgggtca	9	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:86985420G>A	ENST00000395169.3	-	11	1715	c.996_splice	c.e11+1	p.A332_splice	MAPK10_ENST00000449047.2_Splice_Site_p.A225_splice|MAPK10_ENST00000395160.3_Splice_Site_p.A225_splice|MAPK10_ENST00000361569.2_Splice_Site_p.A370_splice|MAPK10_ENST00000395166.1_Splice_Site_p.A332_splice|MAPK10_ENST00000359221.3_Splice_Site_p.A370_splice|MAPK10_ENST00000395157.3_Splice_Site_p.A225_splice|MAPK10_ENST00000395161.2_Splice_Site_p.A370_splice	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	370	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		ATTTCTTACCGCCTCCACTTC	0.433													24	53					0	0	1	0	0	A	86985420	G	A	86985420	5	1	48	1	0	0	0	0	0	0	1	0	9321	1101	38	1	306	1	MAPK10	4	86985420	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	140614	86985420	104168856	1225	5619										
PTPN13	0	broad.mit.edu	37	chr4	87622929	87622929	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacaaaagaaacttcaggtTctgagggaagccatgaatgt	11	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:87622929T>C	ENST00000436978.1	+	7	1650	c.1170T>C	c.(1168-1170)gtT>gtC	p.V390V	PTPN13_ENST00000411767.2_Silent_p.V390V|PTPN13_ENST00000427191.2_Silent_p.V390V|PTPN13_ENST00000511467.1_Silent_p.V390V|PTPN13_ENST00000316707.6_Silent_p.V390V	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	390						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AACTTCAGGTTCTGAGGGAAG	0.358													17	41					0	0	1	0	0	C	87622929	T	C	87622929	2	2	48	1	0	0	0	0	0	0	0	1	12831	1770	62	4		4	PTPN13	4	87622929	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	637509	87622929	103531347	1226	5620										
PTPN13	0	broad.mit.edu	37	chr4	87684331	87684331	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagcagtcaggatcatcaAacaccaaaacaggcatagtt	7	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:87684331A>C	ENST00000436978.1	+	24	4485	c.4005A>C	c.(4003-4005)caA>caC	p.Q1335H	PTPN13_ENST00000411767.2_Missense_Mutation_p.Q1335H|PTPN13_ENST00000427191.2_Missense_Mutation_p.Q1316H|PTPN13_ENST00000511467.1_Missense_Mutation_p.Q1335H|PTPN13_ENST00000316707.6_Missense_Mutation_p.Q1144H	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1335						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGGATCATCAAACACCAAAAC	0.358													26	81					0	0	1	0	0	C	87684331	A	C	87684331	3	2	48	1	0	0	0	0	1	0	0	0	12831	11	1	4	4095	4	PTPN13	4	87684331	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	61402	87684331	103469945	1227	5621										
SLC10A6	345274	broad.mit.edu	37	chr4	87770058	87770058	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaaactggcagagcagtcCcacagcaatgccccagggtc	10	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:87770058C>T	ENST00000273905.6	-	1	358	c.211G>A	c.(211-213)Gga>Aga	p.G71R	SLC10A6_ENST00000505535.1_5'UTR	NM_197965.2	NP_932069.1	Q3KNW5	SOAT_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 6	71						integral to membrane|plasma membrane	bile acid:sodium symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	9		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		CAGAGCAGTCCCACAGCAATG	0.532													19	47					0	0	1	0	0	T	87770058	C	T	87770058	3	4	48	1	0	0	0	0	1	0	0	0	14432	632	22	3	946	3	SLC10A6	4	87770058	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	85727	87770058	103384218	1228	5622										
SLC10A6	345274	broad.mit.edu	37	chr4	87770114	87770114	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagcttccggatctccacgGaacatcccaaagagaacatg	8	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:87770114G>A	ENST00000273905.6	-	1	302	c.155C>T	c.(154-156)tCc>tTc	p.S52F	SLC10A6_ENST00000505535.1_5'UTR	NM_197965.2	NP_932069.1	Q3KNW5	SOAT_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 6	52						integral to membrane|plasma membrane	bile acid:sodium symporter activity	p.S52Y(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	9		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		GATCTCCACGGAACATCCCAA	0.557													10	31					0	0	1	0	0	A	87770114	G	A	87770114	3	1	48	1	0	0	0	0	1	0	0	0	14432	1174	41	3	1002	3	SLC10A6	4	87770114	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	56	87770114	103384162	1229	5623										
AFF1	4299	broad.mit.edu	37	chr4	87967346	87967346	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgacgacagaaacctgcttCgaattagagagaaggaaaga	11	6	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:87967346C>T	ENST00000307808.6	+	2	466	c.46C>T	c.(46-48)Cga>Tga	p.R16*	AFF1_ENST00000544085.1_Intron|AFF1_ENST00000395146.4_Nonsense_Mutation_p.R23*	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	16						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AAACCTGCTTCGAATTAGAGA	0.403													33	67					0	0	1	0	0	T	87967346	C	T	87967346	4	4	48	1	0	0	0	0	0	1	0	0	355	876	31	1	94	1	AFF1	4	87967346	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	197232	87967346	103186930	1230	5624										
SPARCL1	8404	broad.mit.edu	37	chr4	88400658	88400658	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggggtcacactcctcaaaGaaacgggttatgcagtgttc	11	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:88400658G>T	ENST00000418378.1	-	11	2461	c.1890C>A	c.(1888-1890)ttC>ttA	p.F630L	SPARCL1_ENST00000282470.6_Missense_Mutation_p.F630L|SPARCL1_ENST00000503414.1_Missense_Mutation_p.F505L	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	630	EF-hand.				signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		ACTCCTCAAAGAAACGGGTTA	0.463													28	78					2.41591e-17	3.2383e-17	1	1	0	T	88400658	G	T	88400658	3	4	48	1	0	0	0	0	1	0	0	0	15051	933	33	2	112	2	SPARCL1	4	88400658	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	433312	88400658	102753618	1231	5625										
MEPE	56955	broad.mit.edu	37	chr4	88766288	88766288	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagtaaatctcaaaattatTtcacaaatagacagagactg	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:88766288T>C	ENST00000497649.2	+	6	574	c.196T>C	c.(196-198)Ttc>Ctc	p.F66L	MEPE_ENST00000560249.1_5'UTR|MEPE_ENST00000361056.3_Missense_Mutation_p.F90L|MEPE_ENST00000540395.1_5'UTR|MEPE_ENST00000511670.1_3'UTR|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000395102.4_Missense_Mutation_p.F121L|MEPE_ENST00000424957.3_Missense_Mutation_p.F90L			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	90					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TCAAAATTATTTCACAAATAG	0.338													23	42					0	0	1	0	0	C	88766288	T	C	88766288	3	2	48	1	0	0	0	0	1	0	0	0	9527	1841	64	4	278	4	MEPE	4	88766288	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	365630	88766288	102387988	1232	5626										
MEPE	56955	broad.mit.edu	37	chr4	88766449	88766449	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgaccaagaagaatatggCgcagctctcatcagaaataa	8	9	2	4	rs145299039	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:88766449C>T	ENST00000497649.2	+	6	735	c.357C>T	c.(355-357)ggC>ggT	p.G119G	MEPE_ENST00000560249.1_Silent_p.G30G|MEPE_ENST00000361056.3_Silent_p.G143G|MEPE_ENST00000540395.1_Silent_p.G30G|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000395102.4_Silent_p.G174G|MEPE_ENST00000424957.3_Silent_p.G143G			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	143					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AAGAATATGGCGCAGCTCTCA	0.428													29	49					0	0	1	0	0	T	88766449	C	T	88766449	2	4	48	1	0	0	0	0	0	0	0	1	9527	755	27	1		1	MEPE	4	88766449	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	161	88766449	102387827	1233	5627										
ABCG2	9429	broad.mit.edu	37	chr4	89052995	89052995	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacatttgaaattggcaggtCgcggtgctccatttatcaga	10	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:89052995C>T	ENST00000237612.3	-	4	883	c.338G>A	c.(337-339)cGa>cAa	p.R113Q	ABCG2_ENST00000515655.1_Missense_Mutation_p.R113Q	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	113	ABC transporter.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	ATTGGCAGGTCGCGGTGCTCC	0.393													7	24					0	0	1	0	0	T	89052995	C	T	89052995	3	4	48	1	0	0	0	0	1	0	0	0	69	884	31	1	1681	1	ABCG2	4	89052995	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	286546	89052995	102101281	1234	5628										
HERC3	8916	broad.mit.edu	37	chr4	89577136	89577136	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatgttaagtgcccatctcCtgtcaagggttactgggctg	11	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:89577136C>A	ENST00000402738.1	+	9	1258	c.1019C>A	c.(1018-1020)cCt>cAt	p.P340H	HERC3_ENST00000264345.3_Missense_Mutation_p.P340H|HERC3_ENST00000407637.1_Missense_Mutation_p.P340H	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	340					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TGCCCATCTCCTGTCAAGGGT	0.463													23	33					9.95505e-16	1.31587e-15	1	1	0	A	89577136	C	A	89577136	3	1	48	1	0	0	0	0	1	0	0	0	7099	681	24	5	1045	5	HERC3	4	89577136	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	524141	89577136	101577140	1235	5629										
MMRN1	22915	broad.mit.edu	37	chr4	90816089	90816089	+	Translation_Start_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaggattttgtccccaaaTttcacatgagctaccttgct	6	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:90816089T>G	ENST00000394980.1	+	0	286				MMRN1_ENST00000264790.2_De_novo_Start_OutOfFrame			Q13201	MMRN1_HUMAN	multimerin 1						cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGTCCCCAAATTTCACATGAG	0.423													14	26					0	0	1	0	0	G	90816089	T	G	90816089	1	3	48	1	0	0	0	0	0	0	0	0	9718	1508	52	4		4	MMRN1	4	90816089	Translation_Start_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1238953	90816089	100338187	1236	5630										
MMRN1	22915	broad.mit.edu	37	chr4	90816240	90816240	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaactctcagaagactatgCcttctgcttcagttcctcca	7	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:90816240C>T	ENST00000394980.1	+	2	437	c.118C>T	c.(118-120)Cct>Tct	p.P40S	MMRN1_ENST00000264790.2_Missense_Mutation_p.P40S|MMRN1_ENST00000394981.1_Missense_Mutation_p.P40S			Q13201	MMRN1_HUMAN	multimerin 1	40					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GAAGACTATGCCTTCTGCTTC	0.448													23	47					0	0	1	0	0	T	90816240	C	T	90816240	3	4	48	1	0	0	0	0	1	0	0	0	9718	739	26	3	120	3	MMRN1	4	90816240	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	151	90816240	100338036	1237	5631										
MMRN1	22915	broad.mit.edu	37	chr4	90856726	90856726	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttccaatggacaataagaTggacaaaatgagtgagcaac	9	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:90856726T>G	ENST00000394980.1	+	7	2214	c.1895T>G	c.(1894-1896)aTg>aGg	p.M632R	MMRN1_ENST00000508372.1_Missense_Mutation_p.M374R|MMRN1_ENST00000264790.2_Missense_Mutation_p.M632R|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	632					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GACAATAAGATGGACAAAATG	0.358													34	44					0	0	1	0	0	G	90856726	T	G	90856726	3	3	48	1	0	0	0	0	1	0	0	0	9718	1464	51	4	1917	4	MMRN1	4	90856726	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	40486	90856726	100297550	1238	5632										
MMRN1	22915	broad.mit.edu	37	chr4	90857447	90857447	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtctaaagttacccagacGctcataccttattatatttc	5	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:90857447G>A	ENST00000394980.1	+	7	2935	c.2616G>A	c.(2614-2616)acG>acA	p.T872T	MMRN1_ENST00000508372.1_Silent_p.T614T|MMRN1_ENST00000264790.2_Silent_p.T872T|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	872					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTACCCAGACGCTCATACCTT	0.343													10	17					0	0	1	0	0	A	90857447	G	A	90857447	2	1	48	1	0	0	0	0	0	0	0	1	9718	1074	38	1		1	MMRN1	4	90857447	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	721	90857447	100296829	1239	5633										
GRID2	2895	broad.mit.edu	37	chr4	93511403	93511403	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acattttcagtgacgtttgtTgatggcaacaaccctttcca	7	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:93511403T>G	ENST00000282020.4	+	2	468	c.210T>G	c.(208-210)gtT>gtG	p.V70V	GRID2_ENST00000510992.1_Silent_p.V70V|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	70					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGACGTTTGTTGATGGCAACA	0.383													30	67					0	0	1	0	0	G	93511403	T	G	93511403	2	3	48	1	0	0	0	0	0	0	0	1	6812	1799	63	4		4	GRID2	4	93511403	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2653956	93511403	97642873	1240	5634										
GRID2	2895	broad.mit.edu	37	chr4	94344033	94344033	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actacctgggttttaactacGaaatttacgtagcaccggat	8	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:94344033G>A	ENST00000282020.4	+	10	1717	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K	GRID2_ENST00000510992.1_Missense_Mutation_p.E392K	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	487					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.E487Q(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTTTAACTACGAAATTTACGT	0.418													16	33					0	0	1	0	0	A	94344033	G	A	94344033	3	1	48	1	0	0	0	0	1	0	0	0	6812	1059	37	1	1497	1	GRID2	4	94344033	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	832630	94344033	96810243	1241	5635										
SMARCAD1	56916	broad.mit.edu	37	chr4	95158103	95158103	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttttctcgttctgttagTtgattgaatcaacaagcact	6	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:95158103T>G	ENST00000354268.4	+	5	611	c.537_splice	c.e5-1	p.L180_splice	SMARCAD1_ENST00000457823.2_Splice_Site_p.L180_splice			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	180	CUE 1.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GTTCTGTTAGTTGATTGAATC	0.318													13	35					0	0	1	0	0	G	95158103	T	G	95158103	5	3	48	1	0	0	0	0	0	0	1	0	14825	1739	60	4	552	4	SMARCAD1	4	95158103	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	814070	95158103	95996173	1242	5636										
SMARCAD1	56916	broad.mit.edu	37	chr4	95196044	95196044	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtttttaaattctaggttCtcaagaagaacgtaaacaaa	6	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:95196044C>A	ENST00000354268.4	+	14	1809	c.1736C>A	c.(1735-1737)tCt>tAt	p.S579Y	SMARCAD1_ENST00000457823.2_Missense_Mutation_p.S579Y|SMARCAD1_ENST00000509418.1_Missense_Mutation_p.S149Y			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	579	Helicase ATP-binding.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		ATTCTAGGTTCTCAAGAAGAA	0.284													17	23					9.16793e-09	1.08598e-08	1	1	0	A	95196044	C	A	95196044	3	1	48	1	0	0	0	0	1	0	0	0	14825	913	32	2	1786	2	SMARCAD1	4	95196044	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	37941	95196044	95958232	1243	5637										
SMARCAD1	56916	broad.mit.edu	37	chr4	95200129	95200129	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcagttgaggaaaatggcCaatcatcctttattacatcg	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:95200129C>T	ENST00000354268.4	+	19	2419	c.2346C>T	c.(2344-2346)gcC>gcT	p.A782A	SMARCAD1_ENST00000457823.2_Silent_p.A784A|SMARCAD1_ENST00000509418.1_Silent_p.A352A			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	782					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GGAAAATGGCCAATCATCCTT	0.343													7	16					0	0	1	0	0	T	95200129	C	T	95200129	2	4	48	1	0	0	0	0	0	0	0	1	14825	581	21	3		3	SMARCAD1	4	95200129	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4085	95200129	95954147	1244	5638										
SMARCAD1	56916	broad.mit.edu	37	chr4	95201893	95201893	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttagattctggaaaatttCgagttttaggatgcatcttg	9	4	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:95201893C>T	ENST00000354268.4	+	20	2642	c.2569C>T	c.(2569-2571)Cga>Tga	p.R857*	SMARCAD1_ENST00000457823.2_Nonsense_Mutation_p.R859*|SMARCAD1_ENST00000509418.1_Nonsense_Mutation_p.R427*			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	857					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TGGAAAATTTCGAGTTTTAGG	0.308													41	59					0	0	1	0	0	T	95201893	C	T	95201893	4	4	48	1	0	0	0	0	0	1	0	0	14825	876	31	1	2649	1	SMARCAD1	4	95201893	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1764	95201893	95952383	1245	5639										
EIF4E	1977	broad.mit.edu	37	chr4	99823086	99823086	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaacctcctgattagattcCgttttctcctcttctgtagt	6	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:99823086C>T	ENST00000450253.2	-	2	1590	c.66G>A	c.(64-66)acG>acA	p.T22T	EIF4E_ENST00000280892.6_Silent_p.T42T|EIF4E_ENST00000504472.1_5'UTR|EIF4E_ENST00000504432.1_Silent_p.T50T|EIF4E_ENST00000505992.1_Silent_p.T22T	NM_001968.3	NP_001959.1	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	22					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity	p.T22T(2)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)		GATTAGATTCCGTTTTCTCCT	0.388													41	88					0	0	1	0	0	T	99823086	C	T	99823086	2	4	48	1	0	0	0	0	0	0	0	1	5056	639	23	1		1	EIF4E	4	99823086	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4621193	99823086	91331190	1246	5640										
ADH6	130	broad.mit.edu	37	chr4	100129875	100129875	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagaagtctataccagcatCtgtcatatcaaataaaactt	5	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:100129875C>T	ENST00000394897.1	-	6	860	c.778G>A	c.(778-780)Gat>Aat	p.D260N	ADH6_ENST00000394899.2_Missense_Mutation_p.D260N|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.D260N|RP11-696N14.1_ENST00000506454.1_RNA|ADH6_ENST00000407820.2_Missense_Mutation_p.D51N|RP11-696N14.1_ENST00000506160.1_RNA|ADH6_ENST00000504257.1_5'UTR			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	260					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	ATACCAGCATCTGTCATATCA	0.408													81	186					0	0	1	0	0	T	100129875	C	T	100129875	3	4	48	1	0	0	0	0	1	0	0	0	311	913	32	3	369	3	ADH6	4	100129875	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	306789	100129875	91024401	1247	5641										
ADH6	130	broad.mit.edu	37	chr4	100130081	100130081	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcacaggtagaacctggaGtcacctaaacacatacaggc	9	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:100130081G>T	ENST00000394897.1	-	6	654	c.572C>A	c.(571-573)aCt>aAt	p.T191N	ADH6_ENST00000394899.2_Missense_Mutation_p.T191N|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.T191N|RP11-696N14.1_ENST00000506454.1_RNA|ADH6_ENST00000407820.2_5'UTR|RP11-696N14.1_ENST00000506160.1_RNA|ADH6_ENST00000504257.1_5'UTR			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	191					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	AGAACCTGGAGTCACCTAAAC	0.453													22	259					1.28384e-07	1.48174e-07	1	1	0	T	100130081	G	T	100130081	3	4	48	1	0	0	0	0	1	0	0	0	311	1029	36	5	575	5	ADH6	4	100130081	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	206	100130081	91024195	1248	5642										
ADH1B	125	broad.mit.edu	37	chr4	100235062	100235062	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcacttcctgaatgggtttCttgtagtcttgagggttgat	12	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:100235062C>A	ENST00000305046.8	-	6	811	c.744G>T	c.(742-744)aaG>aaT	p.K248N	ADH1B_ENST00000394887.3_Missense_Mutation_p.K208N			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	248					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GAATGGGTTTCTTGTAGTCTT	0.463													103	219					3.22635e-48	4.68053e-48	1	1	0	A	100235062	C	A	100235062	3	1	48	1	0	0	0	0	1	0	0	0	307	912	32	2	399	2	ADH1B	4	100235062	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	104981	100235062	90919214	1249	5643										
ADH1C	126	broad.mit.edu	37	chr4	100257772	100257772	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcccatcaatttccatttCtttggaaagctcccacgtgt	5	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:100257772C>A	ENST00000515683.1	-	0	1616					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	ATTTCCATTTCTTTGGAAAGC	0.348													3	5					6.4e-05	6.95424e-05	1	1	0	A	100257772	C	A	100257772	1	1	48	0	1	0	0	0	0	0	0	0	308	928	32	2		2	ADH1C	4	100257772	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22710	100257772	90896504	1250	5644										
BDH2	56898	broad.mit.edu	37	chr4	104003288	104003288	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctatttcttctgcagttgCgaatcttcccgtcttttgtc	8	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:104003288C>T	ENST00000296424.4	-	9	754	c.634G>A	c.(634-636)Gca>Aca	p.A212T		NM_020139.3	NP_064524.3	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	212					fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|urinary_tract(1)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		TCTGCAGTTGCGAATCTTCCC	0.463													6	14					0	0	1	0	0	T	104003288	C	T	104003288	3	4	48	1	0	0	0	0	1	0	0	0	1389	768	27	1	111	1	BDH2	4	104003288	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3745516	104003288	87150988	1251	5645										
CENPE	1062	broad.mit.edu	37	chr4	104061119	104061119	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcacactttgcatagataAgttttgggcctcaaattgct	7	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:104061119A>C	ENST00000265148.3	-	38	6120	c.6031T>G	c.(6031-6033)Tta>Gta	p.L2011V	CENPE_ENST00000380026.3_Intron	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2011				AQNLSMQSVR -> PNYLCKCE (in Ref. 1; CAA78727).	blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGCATAGATAAGTTTTGGGCC	0.328													14	31					0	0	1	0	0	C	104061119	A	C	104061119	3	2	48	1	0	0	0	0	1	0	0	0	3252	69	3	4	2122	4	CENPE	4	104061119	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	57831	104061119	87093157	1252	5646										
TET2	54790	broad.mit.edu	37	chr4	106158562	106158562	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatccagaattagcaaatTtatcttcagatatgggattt	6	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:106158562T>C	ENST00000305737.2	+	3	3867	c.3463T>C	c.(3463-3465)Tta>Cta	p.L1155L	TET2_ENST00000545826.1_Intron|TET2_ENST00000540549.1_Intron|TET2_ENST00000413648.2_Intron|TET2_ENST00000513237.1_Intron|TET2_ENST00000394764.1_Silent_p.L1155L|TET2_ENST00000380013.4_Intron	NM_017628.4	NP_060098.3	Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	0					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ATTAGCAAATTTATCTTCAGA	0.353			"Mis N, F"		MDS								16	30					0	0	1	0	0	C	106158562	T	C	106158562	2	2	48	1	0	0	0	0	0	0	0	1	15828	1838	64	4		4	TET2	4	106158562	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2097443	106158562	84995714	1253	5647										
NPNT	255743	broad.mit.edu	37	chr4	106879674	106879674	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgaaatatttgaaatagaAagaggagtcagtgcagacga	11	3	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:106879674A>G	ENST00000379987.2	+	9	1422	c.1206A>G	c.(1204-1206)gaA>gaG	p.E402E	NPNT_ENST00000506666.1_Intron|NPNT_ENST00000305572.8_Intron|NPNT_ENST00000453617.2_Silent_p.E419E|NPNT_ENST00000427316.2_Silent_p.E432E|NPNT_ENST00000514622.1_Intron	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	402					cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		TTGAAATAGAAAGAGGAGTCA	0.373													8	20					0	0	1	0	0	G	106879674	A	G	106879674	2	3	48	1	0	0	0	0	0	0	0	1	10637	11	1	4		4	NPNT	4	106879674	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	721112	106879674	84274602	1254	5648										
AIMP1	9255	broad.mit.edu	37	chr4	107252909	107252909	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtttcccgtctggatcttCgaattggttgcatcataact	8	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:107252909C>T	ENST00000394701.4	+	5	585	c.544C>T	c.(544-546)Cga>Tga	p.R182*	AIMP1_ENST00000358008.3_Nonsense_Mutation_p.R158*|AIMP1_ENST00000442366.1_Nonsense_Mutation_p.R158*	NM_001142416.1	NP_001135888.1	Q12904	AIMP1_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	158	Interaction with HSP90B1 (By similarity).|Required for endothelial cell migration.|tRNA-binding.				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding			breast(1)|endometrium(2)|kidney(1)|lung(5)|skin(1)|urinary_tract(1)	11						TCTGGATCTTCGAATTGGTTG	0.413													55	97					0	0	1	0	0	T	107252909	C	T	107252909	4	4	48	1	0	0	0	0	0	1	0	0	430	876	31	1	562	1	AIMP1	4	107252909	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	373235	107252909	83901367	1255	5649										
RPL34	6164	broad.mit.edu	37	chr4	109543322	109543322	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaggttgggaaagcaccaAaatctgcatgtggtgtgtgc	14	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:109543322A>C	ENST00000394668.2	+	3	193	c.127A>C	c.(127-129)Aaa>Caa	p.K43Q	RPL34_ENST00000506397.1_Missense_Mutation_p.K43Q|RPL34_ENST00000394667.3_Missense_Mutation_p.K43Q|RPL34_ENST00000502534.1_Missense_Mutation_p.K43Q|RPL34_ENST00000394665.1_Missense_Mutation_p.K43Q	NM_033625.2	NP_296374.1	P49207	RL34_HUMAN	ribosomal protein L34	43					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			kidney(2)|lung(1)|upper_aerodigestive_tract(1)	4		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000286)		GAAAGCACCAAAATCTGCATG	0.448													15	29					0	0	1	0	0	C	109543322	A	C	109543322	3	2	48	1	0	0	0	0	1	0	0	0	13634	15	1	4	133	4	RPL34	4	109543322	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2290413	109543322	81610954	1256	5650										
EGF	1950	broad.mit.edu	37	chr4	110864438	110864438	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatatagagaaaaatgtttCtggaatggcaataaattgga	9	2	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:110864438C>A	ENST00000265171.5	+	3	801	c.356C>A	c.(355-357)tCt>tAt	p.S119Y	EGF_ENST00000509793.1_Missense_Mutation_p.S119Y|EGF_ENST00000503392.1_Missense_Mutation_p.S119Y|EGF_ENST00000502723.1_3'UTR	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	119					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AAAAATGTTTCTGGAATGGCA	0.264													17	39					3.99206e-14	5.17458e-14	1	1	0	A	110864438	C	A	110864438	3	1	48	1	0	0	0	0	1	0	0	0	4988	913	32	2	366	2	EGF	4	110864438	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1321116	110864438	80289838	1257	5651										
EGF	1950	broad.mit.edu	37	chr4	110865047	110865047	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagcctttatagagcagatCtcgatggtgtgggagtgaag	15	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:110865047C>A	ENST00000265171.5	+	4	1004	c.559C>A	c.(559-561)Ctc>Atc	p.L187I	EGF_ENST00000509793.1_Missense_Mutation_p.L187I|EGF_ENST00000503392.1_Missense_Mutation_p.L187I|EGF_ENST00000502723.1_3'UTR	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	187					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TAGAGCAGATCTCGATGGTGT	0.423													10	34					9.70103e-10	1.17791e-09	1	1	0	A	110865047	C	A	110865047	3	1	48	1	0	0	0	0	1	0	0	0	4988	913	32	2	573	2	EGF	4	110865047	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	609	110865047	80289229	1258	5652										
TIFA	92610	broad.mit.edu	37	chr4	113199456	113199456	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttcgctggaagggagtttCtctctgttaaaacttattga	9	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:113199456C>A	ENST00000361717.2	-	2	398	c.117G>T	c.(115-117)gaG>gaT	p.E39D	TIFA_ENST00000500655.2_Missense_Mutation_p.E39D	NM_052864.2	NP_443096.1	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with forkhead-associated domain	39							protein binding			breast(2)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)	6		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		AAGGGAGTTTCTCTCTGTTAA	0.428													38	62					4.00102e-26	5.65269e-26	1	1	0	A	113199456	C	A	113199456	3	1	48	1	0	0	0	0	1	0	0	0	15953	912	32	2	441	2	TIFA	4	113199456	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2334409	113199456	77954820	1259	5653										
ALPK1	80216	broad.mit.edu	37	chr4	113352752	113352752	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cataataccccaggcattttCttggcccctggtgcagggct	10	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:113352752C>A	ENST00000458497.1	+	11	2328	c.2049C>A	c.(2047-2049)ttC>ttA	p.F683L	ALPK1_ENST00000177648.9_Missense_Mutation_p.F683L|ALPK1_ENST00000504176.2_Missense_Mutation_p.F605L	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	683							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CAGGCATTTTCTTGGCCCCTG	0.498													27	37					6.32553e-13	8.04352e-13	1	1	0	A	113352752	C	A	113352752	3	1	48	1	0	0	0	0	1	0	0	0	540	912	32	2	2083	2	ALPK1	4	113352752	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	153296	113352752	77801524	1260	5654										
NEUROG2	63973	broad.mit.edu	37	chr4	113436535	113436535	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgtcggcgctggatgacaGcggggtcagggccgccaagg	18	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:113436535G>A	ENST00000313341.3	-	2	423	c.97C>T	c.(97-99)Ctg>Ttg	p.L33L		NM_024019.3	NP_076924.1	Q9H2A3	NGN2_HUMAN	neurogenin 2	33					positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			central_nervous_system(1)|large_intestine(3)|lung(6)|skin(2)	12		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		CTGGATGACAGCGGGGTCAGG	0.701													9	26					0	0	1	0	0	A	113436535	G	A	113436535	2	1	48	1	0	0	0	0	0	0	0	1	10399	962	34	3		3	NEUROG2	4	113436535	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	83783	113436535	77717741	1261	5655										
C4orf21	55345	broad.mit.edu	37	chr4	113540667	113540667	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttgtaagtcacaatgttCtcagggtctgccagtatatt	8	8	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:113540667C>T	ENST00000505019.1	-	6	656	c.531G>A	c.(529-531)gaG>gaA	p.E177E	C4orf21_ENST00000445203.2_Silent_p.E146E|C4orf21_ENST00000309071.5_Silent_p.E177E	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	177										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TCACAATGTTCTCAGGGTCTG	0.408													18	33					0	0	1	0	0	T	113540667	C	T	113540667	2	4	48	1	0	0	0	0	0	0	0	1	2269	912	32	3		3	C4orf21	4	113540667	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	104132	113540667	77613609	1262	5656										
ANK2	287	broad.mit.edu	37	chr4	114095638	114095638	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggacaaagttgtggaatatCtgaaggggggcatagacatc	14	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:114095638C>A	ENST00000357077.4	+	2	204	c.151C>A	c.(151-153)Ctg>Atg	p.L51M	ANK2_ENST00000394537.3_Missense_Mutation_p.L51M|ANK2_ENST00000264366.6_Missense_Mutation_p.L51M|ANK2_ENST00000506722.1_Missense_Mutation_p.L30M	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	51					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGTGGAATATCTGAAGGGGGG	0.463													11	22					6.40141e-05	6.95424e-05	1	1	0	A	114095638	C	A	114095638	3	1	48	1	0	0	0	0	1	0	0	0	617	912	32	2	182	2	ANK2	4	114095638	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	554971	114095638	77058638	1263	5657										
ANK2	287	broad.mit.edu	37	chr4	114275856	114275856	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaagagaaaggtaaagttCgggtagaaaaagaaaagggg	14	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:114275856C>T	ENST00000357077.4	+	38	6135	c.6082C>T	c.(6082-6084)Cgg>Tgg	p.R2028W	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.R1995W|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1995					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.R2028W(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGGTAAAGTTCGGGTAGAAAA	0.463													49	74					0	0	1	0	0	T	114275856	C	T	114275856	3	4	48	1	0	0	0	0	1	0	0	0	617	875	31	1	6297	1	ANK2	4	114275856	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	180218	114275856	76878420	1264	5658										
ANK2	287	broad.mit.edu	37	chr4	114275979	114275979	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaatccaaaagaggagttCgtgtttcctccataggagtt	10	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:114275979C>T	ENST00000357077.4	+	38	6258	c.6205C>T	c.(6205-6207)Cgt>Tgt	p.R2069C	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.R2036C|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2036					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGAGGAGTTCGTGTTTCCTC	0.468													9	169					0	0	1	0	0	T	114275979	C	T	114275979	3	4	48	1	0	0	0	0	1	0	0	0	617	884	31	1	6420	1	ANK2	4	114275979	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	123	114275979	76878297	1265	5659										
CAMK2D	817	broad.mit.edu	37	chr4	114680550	114680550	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggaattttcatacatcttCtcaccactgagaatgccccc	5	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:114680550C>T	ENST00000454265.2	-	2	944	c.86G>A	c.(85-87)aGa>aAa	p.R29K	CAMK2D_ENST00000394526.2_Missense_Mutation_p.R29K|CAMK2D_ENST00000509907.1_5'UTR|CAMK2D_ENST00000511664.1_Missense_Mutation_p.R29K|CAMK2D_ENST00000514328.1_Missense_Mutation_p.R29K|CAMK2D_ENST00000296402.5_Missense_Mutation_p.R29K|CAMK2D_ENST00000429180.1_Missense_Mutation_p.R29K|CAMK2D_ENST00000394524.3_Missense_Mutation_p.R29K|CAMK2D_ENST00000515496.1_Missense_Mutation_p.R29K|CAMK2D_ENST00000342666.5_Missense_Mutation_p.R29K|CAMK2D_ENST00000394522.3_Missense_Mutation_p.R29K|CAMK2D_ENST00000505990.1_Missense_Mutation_p.R29K|CAMK2D_ENST00000418639.2_Missense_Mutation_p.R29K|CAMK2D_ENST00000379773.2_Missense_Mutation_p.R29K|CAMK2D_ENST00000508738.1_Missense_Mutation_p.R29K			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	29	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		CATACATCTTCTCACCACTGA	0.328													20	47					0	0	1	0	0	T	114680550	C	T	114680550	3	4	48	1	0	0	0	0	1	0	0	0	2619	913	32	3	1576	3	CAMK2D	4	114680550	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	404571	114680550	76473726	1266	5660										
ARSJ	79642	broad.mit.edu	37	chr4	114824392	114824392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataatggatcggtagtgttCgaaatacctgccaggagctt	12	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:114824392C>T	ENST00000315366.7	-	2	1704	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	ARSJ_ENST00000541197.1_Missense_Mutation_p.E280K	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	280						extracellular region	arylsulfatase activity|metal ion binding	p.E280K(1)		endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		CGGTAGTGTTCGAAATACCTG	0.418													29	36					0	0	1	0	0	T	114824392	C	T	114824392	3	4	48	1	0	0	0	0	1	0	0	0	994	893	31	1	965	1	ARSJ	4	114824392	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	143842	114824392	76329884	1267	5661										
UGT8	7368	broad.mit.edu	37	chr4	115544196	115544196	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagaggccaccatacagtgTtcctcctctctgaaggcaga	10	12	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:115544196T>C	ENST00000310836.6	+	2	682	c.160T>C	c.(160-162)Ttc>Ctc	p.F54L	UGT8_ENST00000394511.3_Missense_Mutation_p.F54L	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	54					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		CCATACAGTGTTCCTCCTCTC	0.488													19	54					0	0	1	0	0	C	115544196	T	C	115544196	3	2	48	1	0	0	0	0	1	0	0	0	17024	1725	60	4	162	4	UGT8	4	115544196	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	719804	115544196	75610080	1268	5662										
NDST4	64579	broad.mit.edu	37	chr4	115792003	115792003	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggaggcagagtttgcaatTtcaggttggtccagctctgc	13	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:115792003T>G	ENST00000264363.2	-	7	2318	c.1640A>C	c.(1639-1641)aAa>aCa	p.K547T		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	547	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AGTTTGCAATTTCAGGTTGGT	0.443													21	32					0	0	1	0	0	G	115792003	T	G	115792003	3	3	48	1	0	0	0	0	1	0	0	0	10304	1841	64	4	1010	4	NDST4	4	115792003	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	247807	115792003	75362273	1269	5663										
SYNPO2	171024	broad.mit.edu	37	chr4	119952573	119952573	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctttgctaaaaggcagtcGagaatggagaagtatgtggt	13	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:119952573G>A	ENST00000307142.4	+	4	2839	c.2643G>A	c.(2641-2643)tcG>tcA	p.S881S	SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Silent_p.S881S|SYNPO2_ENST00000434046.2_Silent_p.S881S	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	881						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						AAAGGCAGTCGAGAATGGAGA	0.552													39	78					0	0	1	0	0	A	119952573	G	A	119952573	2	1	48	1	0	0	0	0	0	0	0	1	15513	1045	37	1		1	SYNPO2	4	119952573	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4160570	119952573	71201703	1270	5664										
SYNPO2	171024	broad.mit.edu	37	chr4	119978690	119978690	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaaagcaaacaagagaccAactccttgggaagcagcagc	11	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:119978690A>C	ENST00000307142.4	+	5	3583	c.3387A>C	c.(3385-3387)ccA>ccC	p.P1129P	SYNPO2_ENST00000448416.2_3'UTR	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	780						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ACAAGAGACCAACTCCTTGGG	0.473													22	59					0	0	1	0	0	C	119978690	A	C	119978690	2	2	48	1	0	0	0	0	0	0	0	1	15513	117	5	4		4	SYNPO2	4	119978690	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	26117	119978690	71175586	1271	5665										
PRDM5	11107	broad.mit.edu	37	chr4	121675763	121675763	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttttactgaatccttttTcacagtaaggacattgatag	6	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:121675763T>C	ENST00000264808.3	-	14	1808	c.1568A>G	c.(1567-1569)gAa>gGa	p.E523G	PRDM5_ENST00000428209.2_Missense_Mutation_p.E492G|PRDM5_ENST00000515109.1_Intron|PRDM5_ENST00000506065.1_5'UTR	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	523					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GAATCCTTTTTCACAGTAAGG	0.378													16	19					0	0	1	0	0	C	121675763	T	C	121675763	3	2	48	1	0	0	0	0	1	0	0	0	12511	1783	62	4	336	4	PRDM5	4	121675763	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1697073	121675763	69478513	1272	5666										
PRDM5	11107	broad.mit.edu	37	chr4	121720877	121720877	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaatttcttcatacattcTtgacaatcaaatatctcatg	2	8	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:121720877T>G	ENST00000264808.3	-	9	1209	c.969A>C	c.(967-969)caA>caC	p.Q323H	PRDM5_ENST00000428209.2_Missense_Mutation_p.Q292H|PRDM5_ENST00000515109.1_Missense_Mutation_p.Q292H	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	323					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TCATACATTCTTGACAATCAA	0.299													10	19					0	0	1	0	0	G	121720877	T	G	121720877	3	3	48	1	0	0	0	0	1	0	0	0	12511	1606	56	4	955	4	PRDM5	4	121720877	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	45114	121720877	69433399	1273	5667										
PRDM5	11107	broad.mit.edu	37	chr4	121742491	121742491	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactgccaaatagaaaatgtTttctccttcctgaaacaaat	4	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:121742491T>G	ENST00000264808.3	-	4	550	c.310A>C	c.(310-312)Aac>Cac	p.N104H	PRDM5_ENST00000428209.2_Missense_Mutation_p.N104H|PRDM5_ENST00000515109.1_Missense_Mutation_p.N104H	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	104	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TAGAAAATGTTTTCTCCTTCC	0.338													25	33					0	0	1	0	0	G	121742491	T	G	121742491	3	3	48	1	0	0	0	0	1	0	0	0	12511	1841	64	4	1634	4	PRDM5	4	121742491	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	21614	121742491	69411785	1274	5668										
TNIP3	79931	broad.mit.edu	37	chr4	122053790	122053790	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttagtgtgtacttctacGgatggactttctttactgag	10	7	2	1	rs142456270		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122053790G>A	ENST00000454328.1	-	13	1201	c.974C>T	c.(973-975)cCg>cTg	p.P325L	TNIP3_ENST00000511909.1_5'UTR|TNIP3_ENST00000507879.1_3'UTR|TNIP3_ENST00000057513.3_Missense_Mutation_p.P325L|TNIP3_ENST00000509841.1_3'UTR			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	325										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						GTACTTCTACGGATGGACTTT	0.408													3	27					0	0	1	0	0	A	122053790	G	A	122053790	3	1	48	1	0	0	0	0	1	0	0	0	16375	1116	39	1	7	1	TNIP3	4	122053790	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	311299	122053790	69100486	1275	5669										
TNIP3	79931	broad.mit.edu	37	chr4	122071311	122071311	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctcatggcagaattccaCtcgagacttcctcaaacagt	6	14	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122071311C>A	ENST00000454328.1	-	8	783	c.556G>T	c.(556-558)Gtg>Ttg	p.V186L	TNIP3_ENST00000507879.1_Missense_Mutation_p.V256L|TNIP3_ENST00000057513.3_Missense_Mutation_p.V186L|TNIP3_ENST00000509841.1_Missense_Mutation_p.V263L			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	186										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						CAGAATTCCACTCGAGACTTC	0.438													18	27					2.5808e-16	3.43231e-16	1	1	0	A	122071311	C	A	122071311	3	1	48	1	0	0	0	0	1	0	0	0	16375	565	20	5	445	5	TNIP3	4	122071311	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17521	122071311	69082965	1276	5670										
TNIP3	79931	broad.mit.edu	37	chr4	122078361	122078361	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcccgcgtgctgaggaatCtttccgcggcgtccagtttc	11	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122078361C>A	ENST00000454328.1	-	6	478	c.251G>T	c.(250-252)aGa>aTa	p.R84I	TNIP3_ENST00000507879.1_Missense_Mutation_p.R154I|TNIP3_ENST00000057513.3_Missense_Mutation_p.R84I|TNIP3_ENST00000509841.1_Missense_Mutation_p.R161I			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	84										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						GCTGAGGAATCTTTCCGCGGC	0.587													85	283					2.56221e-42	3.70845e-42	1	1	0	A	122078361	C	A	122078361	3	1	48	1	0	0	0	0	1	0	0	0	16375	913	32	2	758	2	TNIP3	4	122078361	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7050	122078361	69075915	1277	5671										
EXOSC9	5393	broad.mit.edu	37	chr4	122724127	122724127	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagatgtctaagaaattcGaagtgtatagacactgagtc	10	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122724127G>A	ENST00000512454.1	+	3	507	c.291G>A	c.(289-291)tcG>tcA	p.S97S	EXOSC9_ENST00000379663.3_Silent_p.S113S|EXOSC9_ENST00000509980.1_3'UTR|EXOSC9_ENST00000243498.5_Silent_p.S113S			Q06265	EXOS9_HUMAN	exosome component 9	113	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|urinary_tract(1)	16						TAAGAAATTCGAAGTGTATAG	0.378													11	29					0	0	1	0	0	A	122724127	G	A	122724127	2	1	48	1	0	0	0	0	0	0	0	1	5349	1045	37	1		1	EXOSC9	4	122724127	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	645766	122724127	68430149	1278	5672										
EXOSC9	5393	broad.mit.edu	37	chr4	122728757	122728757	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatgcccatttgtgtcagTtttgcctttttccagcaagg	8	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122728757T>C	ENST00000512454.1	+	5	753	c.537T>C	c.(535-537)agT>agC	p.S179S	EXOSC9_ENST00000379663.3_Silent_p.S195S|EXOSC9_ENST00000509980.1_3'UTR|EXOSC9_ENST00000243498.5_Silent_p.S195S			Q06265	EXOS9_HUMAN	exosome component 9	195	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|urinary_tract(1)	16						TTTGTGTCAGTTTTGCCTTTT	0.368													22	29					0	0	1	0	0	C	122728757	T	C	122728757	2	2	48	1	0	0	0	0	0	0	0	1	5349	1722	60	4		4	EXOSC9	4	122728757	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4630	122728757	68425519	1279	5673										
BBS7	0	broad.mit.edu	37	chr4	122749316	122749316	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaaccatagagtctttcaaGatgtgcaggttgctttttgt	9	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122749316G>T	ENST00000264499.4	-	18	2182	c.1999C>A	c.(1999-2001)Ctt>Att	p.L667I	BBS7_ENST00000506636.1_Missense_Mutation_p.L667I	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	667					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AGTCTTTCAAGATGTGCAGGT	0.398									Bardet-Biedl syndrome				12	84					3.07112e-06	3.42433e-06	1	1	0	T	122749316	G	T	122749316	3	4	48	1	0	0	0	0	1	0	0	0	1339	942	33	2	161	2	BBS7	4	122749316	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	20559	122749316	68404960	1280	5674										
BBS7	0	broad.mit.edu	37	chr4	122756435	122756435	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atactggccttcaattgagcGaatctgattcaacacaaaag	7	9	3	2	rs150743868	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122756435G>A	ENST00000264499.4	-	14	1558	c.1375C>T	c.(1375-1377)Cgc>Tgc	p.R459C	BBS7_ENST00000506636.1_Missense_Mutation_p.R459C	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	459					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TCAATTGAGCGAATCTGATTC	0.358									Bardet-Biedl syndrome				21	29					0	0	1	0	0	A	122756435	G	A	122756435	3	1	48	1	0	0	0	0	1	0	0	0	1339	1058	37	1	801	1	BBS7	4	122756435	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7119	122756435	68397841	1281	5675										
BBS7	0	broad.mit.edu	37	chr4	122765149	122765149	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcaagtaaatctattggaAcatcactctatagtcaatat	4	8	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122765149A>G	ENST00000264499.4	-	12	1421	c.1238T>C	c.(1237-1239)gTt>gCt	p.V413A	BBS7_ENST00000506636.1_Missense_Mutation_p.V413A	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	413					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						ATCTATTGGAACATCACTCTA	0.303									Bardet-Biedl syndrome				5	8					0	0	1	0	0	G	122765149	A	G	122765149	3	3	48	1	0	0	0	0	1	0	0	0	1339	43	2	4	946	4	BBS7	4	122765149	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	8714	122765149	68389127	1282	5676										
BBS7	0	broad.mit.edu	37	chr4	122780322	122780322	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactgagaaagaggtctgagCcagatatgtgcctgagaaca	12	8	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:122780322C>A	ENST00000264499.4	-	5	536	c.353G>T	c.(352-354)gGc>gTc	p.G118V	BBS7_ENST00000506636.1_Missense_Mutation_p.G118V	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	118					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						GAGGTCTGAGCCAGATATGTG	0.318									Bardet-Biedl syndrome				39	53					1.03484e-13	1.33003e-13	1	1	0	A	122780322	C	A	122780322	3	1	48	1	0	0	0	0	1	0	0	0	1339	739	26	5	1859	5	BBS7	4	122780322	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15173	122780322	68373954	1283	5677										
KIAA1109	84162	broad.mit.edu	37	chr4	123140528	123140528	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggaagatgacatgtatatgGattttgaagaggttatctca	12	3	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:123140528G>A	ENST00000264501.4	+	21	2654	c.2281G>A	c.(2281-2283)Gat>Aat	p.D761N	KIAA1109_ENST00000455637.1_Missense_Mutation_p.D761N|KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000388738.3_Missense_Mutation_p.D761N			Q2LD37	K1109_HUMAN	KIAA1109	761					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CATGTATATGGATTTTGAAGA	0.353													4	92					0	0	1	0	0	A	123140528	G	A	123140528	3	1	48	1	0	0	0	0	1	0	0	0	8249	1174	41	3	2355	3	KIAA1109	4	123140528	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	360206	123140528	68013748	1284	5678										
IL21	59067	broad.mit.edu	37	chr4	123534041	123534041	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgaatctttctaggaattCtttgggtggttttttctcat	8	5	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:123534041C>A	ENST00000264497.3	-	4	460	c.403G>T	c.(403-405)Gaa>Taa	p.E135*		NM_001207006.2|NM_021803.3	NP_001193935.1|NP_068575.1	Q9HBE4	IL21_HUMAN	interleukin 21	128					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding	p.E135*(1)		NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(3)	8						TCTAGGAATTCTTTGGGTGGT	0.299													15	24					7.93312e-07	8.98086e-07	1	1	0	A	123534041	C	A	123534041	4	1	48	1	0	0	0	0	0	1	0	0	7713	922	32	2	93	2	IL21	4	123534041	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	393513	123534041	67620235	1285	5679										
SPATA5	166378	broad.mit.edu	37	chr4	123949434	123949434	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatccagagtctttcattCgaatgggtattcagccacct	7	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:123949434C>T	ENST00000274008.3	+	11	2032	c.1963C>T	c.(1963-1965)Cga>Tga	p.R655*	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	655					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						GTCTTTCATTCGAATGGGTAT	0.448													42	69					0	0	1	0	0	T	123949434	C	T	123949434	4	4	48	1	0	0	0	0	0	1	0	0	15066	876	31	1	2005	1	SPATA5	4	123949434	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	415393	123949434	67204842	1286	5680										
SPRY1	10252	broad.mit.edu	37	chr4	124323486	124323486	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctattcagataatccttgctCctgttcacaatcacactgct	4	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:124323486C>T	ENST00000394339.2	+	2	1080	c.740C>T	c.(739-741)tCc>tTc	p.S247F	SPRY1_ENST00000339241.1_Missense_Mutation_p.S247F	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	247	Cys-rich.|SPR.				epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						AATCCTTGCTCCTGTTCACAA	0.458													41	79					0	0	1	0	0	T	124323486	C	T	124323486	3	4	48	1	0	0	0	0	1	0	0	0	15160	855	30	3	742	3	SPRY1	4	124323486	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	374052	124323486	66830790	1287	5681										
ANKRD50	57182	broad.mit.edu	37	chr4	125592847	125592847	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccattatctaataatgtccGaatggaatcctctctttcta	4	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:125592847G>A	ENST00000504087.1	-	4	2622	c.1585C>T	c.(1585-1587)Cgg>Tgg	p.R529W	ANKRD50_ENST00000515641.1_Missense_Mutation_p.R350W	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	529										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						AATAATGTCCGAATGGAATCC	0.418													39	63					0	0	1	0	0	A	125592847	G	A	125592847	3	1	48	1	0	0	0	0	1	0	0	0	671	1057	37	1	2708	1	ANKRD50	4	125592847	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1269361	125592847	65561429	1288	5682										
FAT4	79633	broad.mit.edu	37	chr4	126239028	126239028	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtgaacctgagcgaggagGcgcctccgggaagctatgtg	17	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126239028G>A	ENST00000394329.3	+	1	1475	c.1462G>A	c.(1462-1464)Gcg>Acg	p.A488T		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	488	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAGCGAGGAGGCGCCTCCGGG	0.512											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	29					0	0	1	0	0	A	126239028	G	A	126239028	3	1	48	1	0	0	0	0	1	0	0	0	5724	1203	42	3	1464	3	FAT4	4	126239028	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	646181	126239028	64915248	1289	5683										
FAT4	79633	broad.mit.edu	37	chr4	126240330	126240330	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaagctgtggaccctgatGaaggtgtcaatggcatggta	13	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126240330G>T	ENST00000394329.3	+	1	2777	c.2764G>T	c.(2764-2766)Gaa>Taa	p.E922*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	922	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGACCCTGATGAAGGTGTCAA	0.473													12	31					5.50884e-06	6.10489e-06	1	1	0	T	126240330	G	T	126240330	4	4	48	1	0	0	0	0	0	1	0	0	5724	1291	45	2	2766	2	FAT4	4	126240330	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1302	126240330	64913946	1290	5684										
FAT4	79633	broad.mit.edu	37	chr4	126240857	126240857	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagatgtaaatgataacagAcctctttttaacagtaccaa	6	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126240857A>G	ENST00000394329.3	+	1	3304	c.3291A>G	c.(3289-3291)agA>agG	p.R1097R		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1097	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATGATAACAGACCTCTTTTTA	0.393													18	98					0	0	1	0	0	G	126240857	A	G	126240857	2	3	48	1	0	0	0	0	0	0	0	1	5724	272	10	4		4	FAT4	4	126240857	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	527	126240857	64913419	1291	5685										
FAT4	79633	broad.mit.edu	37	chr4	126336725	126336725	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaataccaatcaggaatttCggatagactctgtcacaggt	9	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126336725C>T	ENST00000394329.3	+	5	6620	c.6607C>T	c.(6607-6609)Cgg>Tgg	p.R2203W	FAT4_ENST00000335110.5_Missense_Mutation_p.R501W	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2203	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCAGGAATTTCGGATAGACTC	0.443													42	94					0	0	1	0	0	T	126336725	C	T	126336725	3	4	48	1	0	0	0	0	1	0	0	0	5724	875	31	1	6625	1	FAT4	4	126336725	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	95868	126336725	64817551	1292	5686										
FAT4	79633	broad.mit.edu	37	chr4	126370224	126370224	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattggaaaacctttcccctCgaaaaatacttactgtttcg	5	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126370224C>T	ENST00000394329.3	+	9	8066	c.8053C>T	c.(8053-8055)Cga>Tga	p.R2685*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.R983*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2685	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCTTTCCCCTCGAAAAATACT	0.343													56	75					0	0	1	0	0	T	126370224	C	T	126370224	4	4	48	1	0	0	0	0	0	1	0	0	5724	876	31	1	8087	1	FAT4	4	126370224	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	33499	126370224	64784052	1293	5687										
FAT4	79633	broad.mit.edu	37	chr4	126370783	126370783	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcaatgacaatgctccaaGatttagcagaacttcctatt	5	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126370783G>A	ENST00000394329.3	+	9	8625	c.8612G>A	c.(8611-8613)aGa>aAa	p.R2871K	FAT4_ENST00000335110.5_Missense_Mutation_p.R1169K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2871	Cadherin 27.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AATGCTCCAAGATTTAGCAGA	0.403													37	40					0	0	1	0	0	A	126370783	G	A	126370783	3	1	48	1	0	0	0	0	1	0	0	0	5724	942	33	3	8646	3	FAT4	4	126370783	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	559	126370783	64783493	1294	5688										
FAT4	79633	broad.mit.edu	37	chr4	126371571	126371571	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatttcttcaggaaatgaaGaaggcatttttgcaatcaat	8	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126371571G>T	ENST00000394329.3	+	9	9413	c.9400G>T	c.(9400-9402)Gaa>Taa	p.E3134*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.E1432*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3134	Cadherin 30.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGGAAATGAAGAAGGCATTTT	0.393													10	38					7.48243e-07	8.49459e-07	1	1	0	T	126371571	G	T	126371571	4	4	48	1	0	0	0	0	0	1	0	0	5724	943	33	2	9434	2	FAT4	4	126371571	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	788	126371571	64782705	1295	5689										
FAT4	79633	broad.mit.edu	37	chr4	126411468	126411468	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagtcagggccctgaagaGatctctctgcctttgtgggc	13	11	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:126411468G>T	ENST00000394329.3	+	17	13504	c.13491G>T	c.(13489-13491)gaG>gaT	p.E4497D	FAT4_ENST00000335110.5_Missense_Mutation_p.E2738D	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4497					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCCCTGAAGAGATCTCTCTGC	0.607													47	74					8.86878e-18	1.19361e-17	1	1	0	T	126411468	G	T	126411468	3	4	48	1	0	0	0	0	1	0	0	0	5724	933	33	2	13557	2	FAT4	4	126411468	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	39897	126411468	64742808	1296	5690										
INTU	27152	broad.mit.edu	37	chr4	128605632	128605632	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttaaaatttatgtatggttCtttagataggtaagtacttc	7	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:128605632C>A	ENST00000335251.5	+	7	1353	c.1250C>A	c.(1249-1251)tCt>tAt	p.S417Y		NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	417										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						ATGTATGGTTCTTTAGATAGG	0.303													8	10					5.4927e-09	6.54492e-09	1	1	0	A	128605632	C	A	128605632	3	1	48	1	0	0	0	0	1	0	0	0	7829	913	32	2	1276	2	INTU	4	128605632	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2194164	128605632	62548644	1297	5691										
PLK4	0	broad.mit.edu	37	chr4	128814548	128814548	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagcttgaaagaggagataaAaatgtatatggaccatgcta	10	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:128814548A>C	ENST00000270861.5	+	11	2571	c.2297A>C	c.(2296-2298)aAa>aCa	p.K766T	PLK4_ENST00000507249.1_Missense_Mutation_p.K705T|PLK4_ENST00000513090.1_Missense_Mutation_p.K734T|PLK4_ENST00000515069.1_Missense_Mutation_p.K688T|PLK4_ENST00000514379.1_Missense_Mutation_p.K725T	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	766					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						GAGGAGATAAAAATGTATATG	0.318													14	41					0	0	1	0	0	C	128814548	A	C	128814548	3	2	48	1	0	0	0	0	1	0	0	0	12145	14	1	4	2339	4	PLK4	4	128814548	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	208916	128814548	62339728	1298	5692										
SLC7A11	23657	broad.mit.edu	37	chr4	139101830	139101830	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catatctgggcatttgtatcGaagataaatcagcccagcaa	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:139101830G>A	ENST00000280612.5	-	10	1510	c.1231C>T	c.(1231-1233)Cga>Tga	p.R411*		NM_014331.3	NP_055146.1	Q9UPY5	XCT_HUMAN	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	411					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	CATTTGTATCGAAGATAAATC	0.438													12	21					0	0	1	0	0	A	139101830	G	A	139101830	4	1	48	1	0	0	0	0	0	1	0	0	14748	1066	37	1	286	1	SLC7A11	4	139101830	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10287282	139101830	52052446	1299	5693										
ELF2	1998	broad.mit.edu	37	chr4	139980462	139980462	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccaatggggttccaacaAtgttaatgcttcctgatcca	8	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:139980462A>C	ENST00000394235.2	-	10	1923	c.1421T>G	c.(1420-1422)aTt>aGt	p.I474S	ELF2_ENST00000379549.2_Missense_Mutation_p.I397S|ELF2_ENST00000265495.4_Missense_Mutation_p.I474S|ELF2_ENST00000358635.3_Missense_Mutation_p.I426S|ELF2_ENST00000515489.1_Intron|ELF2_ENST00000510408.1_Missense_Mutation_p.I414S|ELF2_ENST00000379550.1_Missense_Mutation_p.I486S	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	486					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					GGTTCCAACAATGTTAATGCT	0.473													28	47					0	0	1	0	0	C	139980462	A	C	139980462	3	2	48	1	0	0	0	0	1	0	0	0	5082	101	4	4	328	4	ELF2	4	139980462	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	878632	139980462	51173814	1300	5694										
NAA15	80155	broad.mit.edu	37	chr4	140258010	140258010	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgaaaatagaaaccttgGctatgaaaggattaacattg	8	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:140258010G>T	ENST00000296543.5	+	3	471	c.148G>T	c.(148-150)Gct>Tct	p.A50S	NAA15_ENST00000398947.1_Missense_Mutation_p.A50S	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	50					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AGAAACCTTGGCTATGAAAGG	0.289													35	33					6.29468e-14	8.13866e-14	1	1	0	T	140258010	G	T	140258010	3	4	48	1	0	0	0	0	1	0	0	0	10165	1203	42	5	158	5	NAA15	4	140258010	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	277548	140258010	50896266	1301	5695										
NAA15	80155	broad.mit.edu	37	chr4	140262166	140262166	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggataaagacaatcttcaAatcttaagggacctttcctt	7	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:140262166A>C	ENST00000296543.5	+	4	668	c.345A>C	c.(343-345)caA>caC	p.Q115H	NAA15_ENST00000480277.2_3'UTR|NAA15_ENST00000398947.1_Missense_Mutation_p.Q115H	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	115					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						ACAATCTTCAAATCTTAAGGG	0.363													18	29					0	0	1	0	0	C	140262166	A	C	140262166	3	2	48	1	0	0	0	0	1	0	0	0	10165	11	1	4	359	4	NAA15	4	140262166	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4156	140262166	50892110	1302	5696										
SCOC	0	broad.mit.edu	37	chr4	141302251	141302251	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactgacacaaaaagcaaaaGaaagtaagggattgacaccc	8	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:141302251G>T	ENST00000394203.3	+	4	540	c.362G>T	c.(361-363)aGa>aTa	p.R121I	SCOC_ENST00000394205.3_Missense_Mutation_p.R121I|SCOC_ENST00000502535.1_Missense_Mutation_p.R81I|SCOC_ENST00000512749.1_Missense_Mutation_p.R81I|SCOC_ENST00000338517.4_Missense_Mutation_p.R121I|SCOC_ENST00000506597.1_Missense_Mutation_p.R130I|SCOC_ENST00000394201.3_Missense_Mutation_p.R158I|SCOC_ENST00000506322.1_Missense_Mutation_p.R81I	NM_001153585.1	NP_001147057.1	Q9UIL1	SCOC_HUMAN	short coiled-coil protein	158						Golgi apparatus|nucleus	protein binding			kidney(1)|large_intestine(1)|lung(2)|skin(1)	5	all_hematologic(180;0.162)					AAAAGCAAAAGAAAGTAAGGG	0.333													5	20					0.217242	0.218251	1	1	0	T	141302251	G	T	141302251	3	4	48	1	0	0	0	0	1	0	0	0	13986	942	33	2	561	2	SCOC	4	141302251	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1040085	141302251	49852025	1303	5697										
RNF150	57484	broad.mit.edu	37	chr4	141789419	141789419	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggatttgtcgtttcaaGatttcacttcttcacagtcc	6	10	5	1	rs139463111		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:141789419G>T	ENST00000306799.3	-	7	1840	c.1187C>A	c.(1186-1188)tCt>tAt	p.S396Y	RNF150_ENST00000420921.2_Missense_Mutation_p.S297Y|RNF150_ENST00000379512.2_Missense_Mutation_p.S297Y|RNF150_ENST00000515673.1_Missense_Mutation_p.S438Y	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	438						integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					GTCGTTTCAAGATTTCACTTC	0.468													17	34					2.94398e-08	3.45884e-08	1	1	0	T	141789419	G	T	141789419	3	4	48	1	0	0	0	0	1	0	0	0	13502	942	33	2	7	2	RNF150	4	141789419	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	487168	141789419	49364857	1304	5698										
INPP4B	8821	broad.mit.edu	37	chr4	143159024	143159024	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattttctcttacctgcacaAatcttctttaatgtgaaggg	6	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:143159024A>C	ENST00000513000.1	-	13	1262	c.829T>G	c.(829-831)Ttg>Gtg	p.L277V	INPP4B_ENST00000308502.4_Missense_Mutation_p.L277V|INPP4B_ENST00000509777.1_Missense_Mutation_p.L277V|INPP4B_ENST00000262992.4_Missense_Mutation_p.L277V|INPP4B_ENST00000508116.1_Missense_Mutation_p.L277V	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	277					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TACCTGCACAAATCTTCTTTA	0.284													12	15					0	0	1	0	0	C	143159024	A	C	143159024	3	2	48	1	0	0	0	0	1	0	0	0	7796	11	1	4	2005	4	INPP4B	4	143159024	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1369605	143159024	47995252	1305	5699										
GAB1	2549	broad.mit.edu	37	chr4	144381598	144381598	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactcacacgacagtgaagaGaattatgttcccatgaaccc	8	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:144381598G>T	ENST00000262995.4	+	9	2278	c.1851G>T	c.(1849-1851)gaG>gaT	p.E617D	GAB1_ENST00000505913.1_Missense_Mutation_p.E484D|GAB1_ENST00000262994.4_Missense_Mutation_p.E587D	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	587					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					ACAGTGAAGAGAATTATGTTC	0.438													25	136					7.07758e-08	8.2413e-08	1	1	0	T	144381598	G	T	144381598	3	4	48	1	0	0	0	0	1	0	0	0	6182	933	33	2	1885	2	GAB1	4	144381598	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1222574	144381598	46772678	1306	5700										
OTUD4	54726	broad.mit.edu	37	chr4	146058848	146058848	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatattagacacttcattttCatcttctgaactctcttctt	2	10	6	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:146058848C>A	ENST00000454497.2	-	21	3021	c.2884G>T	c.(2884-2886)Gaa>Taa	p.E962*	OTUD4_ENST00000447906.2_Nonsense_Mutation_p.E1027*|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	1026							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					ACTTCATTTTCATCTTCTGAA	0.408													55	112					1.0331e-37	1.4876e-37	1	1	0	A	146058848	C	A	146058848	4	1	48	1	0	0	0	0	0	1	0	0	11360	835	29	2	269	2	OTUD4	4	146058848	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1677250	146058848	45095428	1307	5701										
TTC29	83894	broad.mit.edu	37	chr4	147830222	147830222	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtcaggtaatggtacaggTaatccagtttatcaggctgc	12	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:147830222T>G	ENST00000513335.1	-	6	633	c.434A>C	c.(433-435)tAc>tCc	p.Y145S	TTC29_ENST00000325106.4_Missense_Mutation_p.Y119S|TTC29_ENST00000398886.4_Missense_Mutation_p.Y145S			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	119							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					ATGGTACAGGTAATCCAGTTT	0.597													13	79					0	0	1	0	0	G	147830222	T	G	147830222	3	3	48	1	0	0	0	0	1	0	0	0	16757	1638	57	4	1107	4	TTC29	4	147830222	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1771374	147830222	43324054	1308	5702										
ARHGAP10	79658	broad.mit.edu	37	chr4	148796274	148796274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcaagtcagtttacagccGaaggctacctgtatgtccag	11	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:148796274G>A	ENST00000336498.3	+	8	1044	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K		NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	269	PH.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GTTTACAGCCGAAGGCTACCT	0.453													5	57					0	0	1	0	0	A	148796274	G	A	148796274	3	1	48	1	0	0	0	0	1	0	0	0	859	1059	37	1	835	1	ARHGAP10	4	148796274	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	966052	148796274	42358002	1309	5703										
NR3C2	0	broad.mit.edu	37	chr4	149181258	149181258	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagatccagtagaaacacttCgtaaagtagagctggggaaa	11	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:149181258C>T	ENST00000355292.3	-	3	2131	c.1769G>A	c.(1768-1770)cGa>cAa	p.R590Q	NR3C2_ENST00000358102.3_Missense_Mutation_p.R590Q|NR3C2_ENST00000511528.1_Missense_Mutation_p.R590Q|NR3C2_ENST00000512865.1_Missense_Mutation_p.R590Q|NR3C2_ENST00000344721.4_Missense_Mutation_p.R590Q|NR3C2_ENST00000342437.4_Missense_Mutation_p.R590Q			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	590	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding	p.R590Q(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	AGAAACACTTCGTAAAGTAGA	0.413													12	31					0	0	1	0	0	T	149181258	C	T	149181258	3	4	48	1	0	0	0	0	1	0	0	0	10678	884	31	1	1213	1	NR3C2	4	149181258	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	384984	149181258	41973018	1310	5704										
DCLK2	166614	broad.mit.edu	37	chr4	151023816	151023816	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagttagtgactgtgattcGaagtggagtgaagcctagaa	13	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:151023816G>A	ENST00000296550.7	+	2	1362	c.608G>A	c.(607-609)cGa>cAa	p.R203Q	DCLK2_ENST00000506325.1_Missense_Mutation_p.R203Q|DCLK2_ENST00000302176.8_Missense_Mutation_p.R203Q	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	203	Doublecortin 2.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					ACTGTGATTCGAAGTGGAGTG	0.438													7	50					0	0	1	0	0	A	151023816	G	A	151023816	3	1	48	1	0	0	0	0	1	0	0	0	4315	1058	37	1	614	1	DCLK2	4	151023816	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1842558	151023816	40130460	1311	5705										
LRBA	987	broad.mit.edu	37	chr4	151765812	151765812	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attaatctgtatacttacctTcgctgcagatttccctaaag	5	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:151765812T>C	ENST00000535741.1	-	27	4932	c.4459A>G	c.(4459-4461)Aag>Gag	p.K1487E	LRBA_ENST00000510413.1_Missense_Mutation_p.K1487E|LRBA_ENST00000507224.1_Missense_Mutation_p.K1487E|LRBA_ENST00000357115.3_Missense_Mutation_p.K1487E			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1487						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ATACTTACCTTCGCTGCAGAT	0.323													15	21					0	0	1	0	0	C	151765812	T	C	151765812	3	2	48	1	0	0	0	0	1	0	0	0	8975	1792	62	4	4260	4	LRBA	4	151765812	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	741996	151765812	39388464	1312	5706										
LRBA	987	broad.mit.edu	37	chr4	151774084	151774084	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaaggttttctttgtgtatTtcaaaagtgacctaggtgaa	10	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:151774084T>G	ENST00000535741.1	-	23	3251	c.2778A>C	c.(2776-2778)gaA>gaC	p.E926D	LRBA_ENST00000510413.1_Missense_Mutation_p.E926D|LRBA_ENST00000507224.1_Missense_Mutation_p.E926D|LRBA_ENST00000357115.3_Missense_Mutation_p.E926D			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	926						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CTTTGTGTATTTCAAAAGTGA	0.313													8	11					0	0	1	0	0	G	151774084	T	G	151774084	3	3	48	1	0	0	0	0	1	0	0	0	8975	1838	64	4	5957	4	LRBA	4	151774084	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8272	151774084	39380192	1313	5707										
LRBA	987	broad.mit.edu	37	chr4	151821337	151821337	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgactgtaccaatgaattcCgtggacagataagtatagag	10	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:151821337C>T	ENST00000535741.1	-	14	2261	c.1788G>A	c.(1786-1788)acG>acA	p.T596T	LRBA_ENST00000510413.1_Silent_p.T596T|LRBA_ENST00000507224.1_Silent_p.T596T|LRBA_ENST00000357115.3_Silent_p.T596T			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	596						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CAATGAATTCCGTGGACAGAT	0.408													14	27					0	0	1	0	0	T	151821337	C	T	151821337	2	4	48	1	0	0	0	0	0	0	0	1	8975	639	23	1		1	LRBA	4	151821337	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47253	151821337	39332939	1314	5708										
FBXW7	0	broad.mit.edu	37	chr4	153244185	153244185	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccaatgtgactaggtttcGaataaattcacccgttttca	6	10	2	1	rs144247898		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:153244185G>A	ENST00000281708.4	-	12	3201	c.1972C>T	c.(1972-1974)Cga>Tga	p.R658*	FBXW7_ENST00000296555.5_Nonsense_Mutation_p.R540*|FBXW7_ENST00000393956.3_Nonsense_Mutation_p.R482*|FBXW7_ENST00000603548.1_Nonsense_Mutation_p.R658*|FBXW7_ENST00000603841.1_Nonsense_Mutation_p.R658*|FBXW7_ENST00000263981.5_Nonsense_Mutation_p.R578*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	658					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R658*(3)|p.R578*(1)|p.?(1)|p.R419*(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTAGGTTTCGAATAAATTCA	0.473			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								54	88					0	0	1	0	0	A	153244185	G	A	153244185	4	1	48	1	0	0	0	0	0	1	0	0	5801	1066	37	1	155	1	FBXW7	4	153244185	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1422848	153244185	37910091	1315	5709										
FBXW7	0	broad.mit.edu	37	chr4	153268137	153268137	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggctggacagatgtaattCggcgtcgttgttgcccttgg	15	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:153268137C>T	ENST00000281708.4	-	4	1900	c.671G>A	c.(670-672)cGa>cAa	p.R224Q	FBXW7_ENST00000296555.5_Missense_Mutation_p.R106Q|FBXW7_ENST00000393956.3_Missense_Mutation_p.R48Q|FBXW7_ENST00000603548.1_Missense_Mutation_p.R224Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R224Q|FBXW7_ENST00000263981.5_Missense_Mutation_p.R144Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	224					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGATGTAATTCGGCGTCGTTG	0.448			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								5	98					0	0	1	0	0	T	153268137	C	T	153268137	3	4	48	1	0	0	0	0	1	0	0	0	5801	884	31	1	1488	1	FBXW7	4	153268137	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23952	153268137	37886139	1316	5710										
MND1	84057	broad.mit.edu	37	chr4	154271250	154271250	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgagtgcagaagaaaagaGaactcgcatgatggaaatat	11	5	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:154271250G>T	ENST00000240488.3	+	2	127	c.38G>T	c.(37-39)aGa>aTa	p.R13I	MND1_ENST00000504860.1_5'UTR|MND1_ENST00000503967.1_3'UTR	NM_001253861.1|NM_032117.3	NP_001240790.1|NP_115493.1	Q9BWT6	MND1_HUMAN	meiotic nuclear divisions 1 homolog (S. cerevisiae)	13					DNA recombination|meiosis	nucleus	DNA binding			large_intestine(2)|lung(1)	3	all_hematologic(180;0.093)					GAAGAAAAGAGAACTCGCATG	0.279													10	39					4.68919e-08	5.48405e-08	1	1	0	T	154271250	G	T	154271250	3	4	48	1	0	0	0	0	1	0	0	0	9723	942	33	2	44	2	MND1	4	154271250	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1003113	154271250	36883026	1317	5711										
TLR2	7097	broad.mit.edu	37	chr4	154625574	154625574	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccatgttactagtattgaaAatcagtaggaatgcaataac	7	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:154625574A>C	ENST00000260010.6	+	1	2923	c.1515A>C	c.(1513-1515)aaA>aaC	p.K505N		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	505					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TAGTATTGAAAATCAGTAGGA	0.378													26	38					0	0	1	0	0	C	154625574	A	C	154625574	3	2	48	1	0	0	0	0	1	0	0	0	16010	11	1	4	1517	4	TLR2	4	154625574	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	354324	154625574	36528702	1318	5712										
DCHS2	54798	broad.mit.edu	37	chr4	155156193	155156193	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatcacctgaaataaagacaGactcttttctaacgtcagcc	6	11	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155156193G>T	ENST00000357232.3	-	25	8245	c.8246C>A	c.(8245-8247)tCt>tAt	p.S2749Y		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2749					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AATAAAGACAGACTCTTTTCT	0.443													18	30					1.99824e-07	2.29918e-07	1	1	0	T	155156193	G	T	155156193	3	4	48	1	0	0	0	0	1	0	0	0	4311	942	33	2	508	2	DCHS2	4	155156193	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	530619	155156193	35998083	1319	5713										
DCHS2	54798	broad.mit.edu	37	chr4	155180752	155180752	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acactgatgcctggtaaatgCtttgttcaaagcatggtgaa	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155180752C>A	ENST00000357232.3	-	20	5368	c.5369G>T	c.(5368-5370)aGc>aTc	p.S1790I		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1790	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTGGTAAATGCTTTGTTCAAA	0.408													33	56					4.74835e-14	6.14782e-14	1	1	0	A	155180752	C	A	155180752	3	1	48	1	0	0	0	0	1	0	0	0	4311	797	28	5	3405	5	DCHS2	4	155180752	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	24559	155180752	35973524	1320	5714										
DCHS2	54798	broad.mit.edu	37	chr4	155253722	155253722	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtccatgtcaatagctgtaAttttgcctattaccccttgg	7	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155253722A>C	ENST00000357232.3	-	9	2140	c.2141T>G	c.(2140-2142)aTt>aGt	p.I714S	DCHS2_ENST00000339452.1_Missense_Mutation_p.I1213S	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	714	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AATAGCTGTAATTTTGCCTAT	0.413													47	70					0	0	1	0	0	C	155253722	A	C	155253722	3	2	48	1	0	0	0	0	1	0	0	0	4311	101	4	4	6773	4	DCHS2	4	155253722	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	72970	155253722	35900554	1321	5715										
DCHS2	54798	broad.mit.edu	37	chr4	155312322	155312322	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttttgttcttacctctgaGatttcacaatggaatttatt	5	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155312322G>T	ENST00000357232.3	-	1	127	c.128C>A	c.(127-129)tCt>tAt	p.S43Y	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	43					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTACCTCTGAGATTTCACAAT	0.323													3	18					0.150653	0.151842	1	1	0	T	155312322	G	T	155312322	3	4	48	1	0	0	0	0	1	0	0	0	4311	942	33	2	8818	2	DCHS2	4	155312322	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58600	155312322	35841954	1322	5716										
FGB	2244	broad.mit.edu	37	chr4	155490690	155490690	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atattggcttggaaatgataAaattagccagcttaccagga	9	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155490690A>C	ENST00000302068.4	+	7	1046	c.983A>C	c.(982-984)aAa>aCa	p.K328T	FGB_ENST00000502545.1_Intron|FGB_ENST00000509493.1_Missense_Mutation_p.K109T	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	328	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GGAAATGATAAAATTAGCCAG	0.358													9	67					0	0	1	0	0	C	155490690	A	C	155490690	3	2	48	1	0	0	0	0	1	0	0	0	5863	14	1	4	1009	4	FGB	4	155490690	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	178368	155490690	35663586	1323	5717										
FGA	2243	broad.mit.edu	37	chr4	155505567	155505567	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tactctgccccttcctctacGgaaccctcaatcagagcatc	5	17	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155505567G>A	ENST00000302053.3	-	6	2388	c.2310C>T	c.(2308-2310)tcC>tcT	p.S770S		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	770	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTCCTCTACGGAACCCTCAA	0.527													38	81					0	0	1	0	0	A	155505567	G	A	155505567	2	1	48	1	0	0	0	0	0	0	0	1	5862	1103	39	1		1	FGA	4	155505567	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	14877	155505567	35648709	1324	5718										
FGA	2243	broad.mit.edu	37	chr4	155507462	155507462	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatacagagctctcagaggtCcagtgcccagcacttccgcg	11	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155507462C>T	ENST00000302053.3	-	5	1197	c.1119G>A	c.(1117-1119)tgG>tgA	p.W373*	FGA_ENST00000403106.3_Nonsense_Mutation_p.W373*	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	373					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCTCAGAGGTCCAGTGCCCAG	0.547													8	111					0	0	1	0	0	T	155507462	C	T	155507462	4	4	48	1	0	0	0	0	0	1	0	0	5862	856	30	3	1533	3	FGA	4	155507462	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1895	155507462	35646814	1325	5719										
FGG	2266	broad.mit.edu	37	chr4	155529776	155529776	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatattgaatccagtttttCttgaaatctacactgccatc	4	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155529776C>A	ENST00000404648.3	-	7	932	c.693G>T	c.(691-693)aaG>aaT	p.K231N	FGG_ENST00000336098.3_Missense_Mutation_p.K231N|FGG_ENST00000407946.1_Missense_Mutation_p.K239N|FGG_ENST00000405164.1_Missense_Mutation_p.K239N	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	231	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCCAGTTTTTCTTGAAATCTA	0.358													12	24					0.00010058	0.000108553	1	1	0	A	155529776	C	A	155529776	3	1	48	1	0	0	0	0	1	0	0	0	5902	912	32	2	699	2	FGG	4	155529776	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22314	155529776	35624500	1326	5720										
FGG	2266	broad.mit.edu	37	chr4	155533543	155533543	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaacataaaaactacttacGaatctttcatctaagatgca	4	8	3	1	rs141554929		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:155533543G>A	ENST00000404648.3	-	2	362	c.123_splice	c.e2+1	p.F41_splice	FGG_ENST00000336098.3_Splice_Site_p.F41_splice|FGG_ENST00000407946.1_Splice_Site_p.F41_splice|FGG_ENST00000405164.1_Splice_Site_p.F41_splice	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	41					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AACTACTTACGAATCTTTCAT	0.338													11	145					0	0	1	0	0	A	155533543	G	A	155533543	5	1	48	1	0	0	0	0	0	0	1	0	5902	1072	37	1	1289	1	FGG	4	155533543	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3767	155533543	35620733	1327	5721										
MAP9	79884	broad.mit.edu	37	chr4	156294345	156294345	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtttcatttttattttgtCtttttcaaattcctcatcct	3	8	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:156294345C>A	ENST00000311277.4	-	4	687	c.424G>T	c.(424-426)Gac>Tac	p.D142Y	MAP9_ENST00000515654.1_Missense_Mutation_p.D142Y|AC097467.2_ENST00000596165.1_RNA|MAP9_ENST00000379248.2_Missense_Mutation_p.D70Y	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	142					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TTTATTTTGTCTTTTTCAAAT	0.318													12	18					3.07112e-06	3.42433e-06	1	1	0	A	156294345	C	A	156294345	3	1	48	1	0	0	0	0	1	0	0	0	9319	913	32	2	1563	2	MAP9	4	156294345	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	760802	156294345	34859931	1328	5722										
RXFP1	59350	broad.mit.edu	37	chr4	159533502	159533502	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacattttatggactaaattCtcttattctcttgtaagtac	4	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:159533502C>A	ENST00000307765.5	+	8	919	c.668C>A	c.(667-669)tCt>tAt	p.S223Y	RXFP1_ENST00000460056.2_Missense_Mutation_p.S142Y|RXFP1_ENST00000343542.5_Missense_Mutation_p.S223Y|RXFP1_ENST00000448688.2_Missense_Mutation_p.S142Y|RXFP1_ENST00000470033.1_Missense_Mutation_p.S190Y	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	223						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding	p.S223Y(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GGACTAAATTCTCTTATTCTC	0.274													3	13					6.4e-05	6.95424e-05	1	1	0	A	159533502	C	A	159533502	3	1	48	1	0	0	0	0	1	0	0	0	13810	913	32	2	698	2	RXFP1	4	159533502	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3239157	159533502	31620774	1329	5723										
ETFDH	2110	broad.mit.edu	37	chr4	159627345	159627345	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtttttaataaaaggactCcatgtaactgaatatgagga	8	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:159627345C>T	ENST00000511912.1	+	11	1622	c.1290C>T	c.(1288-1290)ctC>ctT	p.L430L	ETFDH_ENST00000307738.5_Silent_p.L383L	NM_004453.2	NP_004444.2	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	430					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|prostate(1)|skin(3)	28	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		TAAAAGGACTCCATGTAACTG	0.373													9	22					0	0	1	0	0	T	159627345	C	T	159627345	2	4	48	1	0	0	0	0	0	0	0	1	5299	842	30	3		3	ETFDH	4	159627345	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93843	159627345	31526931	1330	5724										
FSTL5	56884	broad.mit.edu	37	chr4	162841649	162841649	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagtggttttcatagaattCtccgtcagatccacacacag	7	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:162841649C>A	ENST00000306100.5	-	4	752	c.316G>T	c.(316-318)Gaa>Taa	p.E106*	FSTL5_ENST00000379164.4_Nonsense_Mutation_p.E105*|FSTL5_ENST00000536695.1_Nonsense_Mutation_p.E105*|FSTL5_ENST00000427802.2_Nonsense_Mutation_p.E105*	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	106	Kazal-like.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCATAGAATTCTCCGTCAGAT	0.438													17	25					1.67942e-08	1.98515e-08	1	1	0	A	162841649	C	A	162841649	4	1	48	1	0	0	0	0	0	1	0	0	6114	922	32	2	2279	2	FSTL5	4	162841649	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3214304	162841649	28312627	1331	5725										
NPY5R	4889	broad.mit.edu	37	chr4	164272343	164272343	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaaagaccttctcaagaGaaccactccagaatacttcc	5	14	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:164272343G>T	ENST00000515560.1	+	4	2440	c.918G>T	c.(916-918)gaG>gaT	p.E306D	NPY5R_ENST00000506953.1_Missense_Mutation_p.E306D|NPY5R_ENST00000338566.3_Missense_Mutation_p.E306D			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	306					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				CTTCTCAAGAGAACCACTCCA	0.418													16	40					0.000422831	0.000449533	1	1	0	T	164272343	G	T	164272343	3	4	48	1	0	0	0	0	1	0	0	0	10657	933	33	2	920	2	NPY5R	4	164272343	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1430694	164272343	26881933	1332	5726										
ANXA10	11199	broad.mit.edu	37	chr4	169086427	169086427	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataacctccaagaggacattTattcagagacctcaggacac	7	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:169086427T>C	ENST00000359299.3	+	6	616	c.430T>C	c.(430-432)Tat>Cat	p.Y144H		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	144							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AGAGGACATTTATTCAGAGAC	0.333													13	24					0	0	1	0	0	C	169086427	T	C	169086427	3	2	48	1	0	0	0	0	1	0	0	0	709	1754	61	4	452	4	ANXA10	4	169086427	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4814084	169086427	22067849	1333	5727										
DDX60	55601	broad.mit.edu	37	chr4	169201497	169201497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attacataccttcttcacttCggcaatgttctttccaggct	5	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:169201497C>T	ENST00000393743.3	-	14	2258	c.1967G>A	c.(1966-1968)cGa>cAa	p.R656Q		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	656							ATP binding|ATP-dependent helicase activity|RNA binding	p.R656Q(2)		breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTCTTCACTTCGGCAATGTTC	0.363													24	49					0	0	1	0	0	T	169201497	C	T	169201497	3	4	48	1	0	0	0	0	1	0	0	0	4401	884	31	1	3271	1	DDX60	4	169201497	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	115070	169201497	21952779	1334	5728										
DDX60L	91351	broad.mit.edu	37	chr4	169300626	169300626	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgcaagtcctgcaaatttCtttggattaccctttttatt	6	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:169300626C>A	ENST00000511577.1	-	32	4498	c.4251G>T	c.(4249-4251)aaG>aaT	p.K1417N	DDX60L_ENST00000260184.7_Missense_Mutation_p.K1417N			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1417							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTGCAAATTTCTTTGGATTAC	0.318													5	22					0.014758	0.015099	1	1	0	A	169300626	C	A	169300626	3	1	48	1	0	0	0	0	1	0	0	0	4402	912	32	2	897	2	DDX60L	4	169300626	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	99129	169300626	21853650	1335	5729										
DDX60L	91351	broad.mit.edu	37	chr4	169317216	169317216	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccaggaaattaatatatTcagctctatacacttttttt	3	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:169317216T>G	ENST00000511577.1	-	27	3798	c.3551A>C	c.(3550-3552)gAa>gCa	p.E1184A	DDX60L_ENST00000505890.1_Missense_Mutation_p.E1185A|DDX60L_ENST00000260184.7_Missense_Mutation_p.E1184A			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1184							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ATTAATATATTCAGCTCTATA	0.308													10	19					0	0	1	0	0	G	169317216	T	G	169317216	3	3	48	1	0	0	0	0	1	0	0	0	4402	1783	62	4	1617	4	DDX60L	4	169317216	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	16590	169317216	21837060	1336	5730										
GLRA3	8001	broad.mit.edu	37	chr4	175565138	175565138	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggttggggccctttggagtCatgccatcctttgcttgtag	13	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:175565138C>A	ENST00000274093.3	-	10	1696	c.1194G>T	c.(1192-1194)atG>atT	p.M398I	GLRA3_ENST00000340217.5_Missense_Mutation_p.M383I	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	398					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	CCTTTGGAGTCATGCCATCCT	0.473													21	55					3.51602e-12	4.42195e-12	1	1	0	A	175565138	C	A	175565138	3	1	48	1	0	0	0	0	1	0	0	0	6497	826	29	2	204	2	GLRA3	4	175565138	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6247922	175565138	15589138	1337	5731										
SPATA4	132851	broad.mit.edu	37	chr4	177113898	177113898	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgataacctaatgttatCtttaatagacttcgaaactg	5	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:177113898C>A	ENST00000515234.1	-	3	1644	c.49G>T	c.(49-51)Gat>Tat	p.D17Y	SPATA4_ENST00000280191.2_Missense_Mutation_p.D190Y			Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	190					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		CTAATGTTATCTTTAATAGAC	0.368													7	23					0.00198382	0.00207034	1	1	0	A	177113898	C	A	177113898	3	1	48	1	0	0	0	0	1	0	0	0	15065	913	32	2	361	2	SPATA4	4	177113898	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1548760	177113898	14040378	1338	5732										
SPATA4	132851	broad.mit.edu	37	chr4	177114180	177114180	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagctttacaatgaattgtTccatggattagttctttagg	8	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:177114180T>C	ENST00000280191.2	-	3	504	c.396A>G	c.(394-396)ggA>ggG	p.G132G	SPATA4_ENST00000515234.1_5'UTR	NM_144644.2	NP_653245.2	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	132					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		AATGAATTGTTCCATGGATTA	0.284													15	24					0	0	1	0	0	C	177114180	T	C	177114180	2	2	48	1	0	0	0	0	0	0	0	1	15065	1770	62	4		4	SPATA4	4	177114180	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	282	177114180	14040096	1339	5733										
ING2	3622	broad.mit.edu	37	chr4	184431545	184431545	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcactaattaatagtcaaGaattgggagatgaaaaaata	9	3	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:184431545G>T	ENST00000302327.3	+	2	485	c.283G>T	c.(283-285)Gaa>Taa	p.E95*	ING2_ENST00000434682.2_Nonsense_Mutation_p.E55*	NM_001564.2	NP_001555.1	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	95					chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	7		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TAATAGTCAAGAATTGGGAGA	0.368													42	90					1.48646e-12	1.88167e-12	1	1	0	T	184431545	G	T	184431545	4	4	48	1	0	0	0	0	0	1	0	0	7779	943	33	2	289	2	ING2	4	184431545	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7317365	184431545	6722731	1340	5734										
ENPP6	133121	broad.mit.edu	37	chr4	185012528	185012528	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagcagctctgaagttggaTttgaaatctgaaagggaaag	14	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:185012528T>G	ENST00000296741.2	-	8	1266	c.1125A>C	c.(1123-1125)aaA>aaC	p.K375N		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	375					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TGAAGTTGGATTTGAAATCTG	0.507													5	97					0	0	1	0	0	G	185012528	T	G	185012528	3	3	48	1	0	0	0	0	1	0	0	0	5162	1490	52	4	201	4	ENPP6	4	185012528	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	580983	185012528	6141748	1341	5735										
CCDC111	0	broad.mit.edu	37	chr4	185580506	185580506	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatgcaggacgttcatgtaTttgctttggaatgcaaagta	10	5	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:185580506T>C	ENST00000314970.6	+	4	626	c.193T>C	c.(193-195)Ttt>Ctt	p.F65L	CCDC111_ENST00000515774.1_5'UTR|CCDC111_ENST00000512834.1_Missense_Mutation_p.F65L|CCDC111_ENST00000503752.1_Missense_Mutation_p.F65L	NM_152683.2	NP_689896.1	Q96LW4	CC111_HUMAN		65					DNA replication, synthesis of RNA primer		DNA primase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(2)	16		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		CGTTCATGTATTTGCTTTGGA	0.338													28	32					0	0	1	0	0	C	185580506	T	C	185580506	3	2	48	1	0	0	0	0	1	0	0	0	2766	1493	52	4	199	4	CCDC111	4	185580506	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	567978	185580506	5573770	1342	5736										
CCDC111	0	broad.mit.edu	37	chr4	185593505	185593505	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagaggaaagctggacatcGaattcaaagaaactggagag	12	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:185593505G>A	ENST00000314970.6	+	7	1168	c.735G>A	c.(733-735)tcG>tcA	p.S245S	CCDC111_ENST00000515774.1_Silent_p.S116S|CCDC111_ENST00000512834.1_Silent_p.S245S|CCDC111_ENST00000503752.1_Silent_p.S245S	NM_152683.2	NP_689896.1	Q96LW4	CC111_HUMAN		245					DNA replication, synthesis of RNA primer		DNA primase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(2)	16		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		GCTGGACATCGAATTCAAAGA	0.428													32	51					0	0	1	0	0	A	185593505	G	A	185593505	2	1	48	1	0	0	0	0	0	0	0	1	2766	1045	37	1		1	CCDC111	4	185593505	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	12999	185593505	5560771	1343	5737										
ACSL1	2180	broad.mit.edu	37	chr4	185681620	185681620	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgtgccagcttaaatatgTgctttttccggtcgataatt	8	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:185681620T>C	ENST00000515030.1	-	18	1998	c.1673A>G	c.(1672-1674)cAc>cGc	p.H558R	ACSL1_ENST00000437665.3_Missense_Mutation_p.H387R|ACSL1_ENST00000454703.2_Missense_Mutation_p.H387R|ACSL1_ENST00000507295.1_Missense_Mutation_p.H524R|ACSL1_ENST00000513317.1_Missense_Mutation_p.H558R|ACSL1_ENST00000281455.2_Missense_Mutation_p.H558R|ACSL1_ENST00000504342.1_Missense_Mutation_p.H558R			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	558					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTTAAATATGTGCTTTTTCCG	0.463													123	255					0	0	1	0	0	C	185681620	T	C	185681620	3	2	48	1	0	0	0	0	1	0	0	0	177	1696	59	4	439	4	ACSL1	4	185681620	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	88115	185681620	5472656	1344	5738										
ACSL1	2180	broad.mit.edu	37	chr4	185697685	185697685	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccccacacctctggcctcGttccaccagttcactgccgt	6	20	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:185697685G>A	ENST00000515030.1	-	7	1034	c.709C>T	c.(709-711)Cga>Tga	p.R237*	ACSL1_ENST00000437665.3_Nonsense_Mutation_p.R66*|ACSL1_ENST00000504900.1_Nonsense_Mutation_p.R237*|ACSL1_ENST00000454703.2_Nonsense_Mutation_p.R66*|ACSL1_ENST00000507295.1_Nonsense_Mutation_p.R203*|ACSL1_ENST00000513317.1_Nonsense_Mutation_p.R237*|ACSL1_ENST00000281455.2_Nonsense_Mutation_p.R237*|ACSL1_ENST00000504342.1_Nonsense_Mutation_p.R237*			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	237					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTCTGGCCTCGTTCCACCAGT	0.517													28	53					0	0	1	0	0	A	185697685	G	A	185697685	4	1	48	1	0	0	0	0	0	1	0	0	177	1153	40	1	1447	1	ACSL1	4	185697685	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16065	185697685	5456591	1345	5739										
KIAA1430	57587	broad.mit.edu	37	chr4	186111423	186111423	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatgtttttctttcccttTtttggctgctttcaaatatt	4	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:186111423T>G	ENST00000458385.2	-	2	1047	c.928A>C	c.(928-930)Aaa>Caa	p.K310Q	KIAA1430_ENST00000296775.6_Missense_Mutation_p.K310Q|KIAA1430_ENST00000514798.1_Missense_Mutation_p.K310Q	NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430	310										endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		TCTTTCCCTTTTTTGGCTGCT	0.333													12	19					0	0	1	0	0	G	186111423	T	G	186111423	3	3	48	1	0	0	0	0	1	0	0	0	8273	1850	64	4	686	4	KIAA1430	4	186111423	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	413738	186111423	5042853	1346	5740										
CCDC110	256309	broad.mit.edu	37	chr4	186380484	186380484	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaacacactgctcagtaacGgaattaactttggaagtttt	8	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:186380484G>A	ENST00000307588.3	-	6	1332	c.1257C>T	c.(1255-1257)tcC>tcT	p.S419S	CCDC110_ENST00000393540.3_Silent_p.S382S|CCDC110_ENST00000510617.1_Silent_p.S419S	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	419						nucleus		p.S419S(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		GCTCAGTAACGGAATTAACTT	0.318													21	64					0	0	1	0	0	A	186380484	G	A	186380484	2	1	48	1	0	0	0	0	0	0	0	1	2765	1103	39	1		1	CCDC110	4	186380484	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	269061	186380484	4773792	1347	5741										
SORBS2	8470	broad.mit.edu	37	chr4	186535983	186535983	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacaaaaaaccagctgggctAcctttctcagtgacagctcc	7	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:186535983A>G	ENST00000431808.1	-	18	3447		c.e18+1		SORBS2_ENST00000437304.2_Splice_Site|SORBS2_ENST00000393528.3_Splice_Site|SORBS2_ENST00000355634.5_Splice_Site|SORBS2_ENST00000319471.9_Splice_Site|SORBS2_ENST00000284776.7_Splice_Site|SORBS2_ENST00000448662.2_Splice_Site|SORBS2_ENST00000449407.2_Splice_Site|SORBS2_ENST00000498125.1_Splice_Site|SORBS2_ENST00000418609.1_Splice_Site			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2							actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CAGCTGGGCTACCTTTCTCAG	0.418													15	34					0	0	1	0	0	G	186535983	A	G	186535983	5	3	48	1	0	0	0	0	0	0	1	0	14981	405	14	4	437	4	SORBS2	4	186535983	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	155499	186535983	4618293	1348	5742										
CYP4V2	285440	broad.mit.edu	37	chr4	187120134	187120134	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtgagatgatatttcgaaGaataaagatgccctggcttt	11	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:187120134G>T	ENST00000378802.4	+	6	1002	c.698G>T	c.(697-699)aGa>aTa	p.R233I		NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	233					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		ATATTTCGAAGAATAAAGATG	0.373													13	38					0.00316338	0.00328853	1	1	0	T	187120134	G	T	187120134	3	4	48	1	0	0	0	0	1	0	0	0	4215	942	33	2	720	2	CYP4V2	4	187120134	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	584151	187120134	4034142	1349	5743										
KLKB1	3818	broad.mit.edu	37	chr4	187175855	187175855	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattattcaccaaaactataAagtctcagaagggaatcatg	6	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:187175855A>C	ENST00000264690.6	+	12	1614	c.1427A>C	c.(1426-1428)aAa>aCa	p.K476T	KLKB1_ENST00000513864.1_Missense_Mutation_p.K476T	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	476	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CAAAACTATAAAGTCTCAGAA	0.363													24	34					0	0	1	0	0	C	187175855	A	C	187175855	3	2	48	1	0	0	0	0	1	0	0	0	8454	14	1	4	1469	4	KLKB1	4	187175855	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	55721	187175855	3978421	1350	5744										
FAT1	2195	broad.mit.edu	37	chr4	187509932	187509932	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctcgacagcgggcgcctcGaagtgtctttgataccctgg	12	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:187509932G>A	ENST00000441802.2	-	27	13790	c.13581C>T	c.(13579-13581)ttC>ttT	p.F4527F		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4527					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CGGGCGCCTCGAAGTGTCTTT	0.562										HNSCC(5;0.00058)			25	39					0	0	1	0	0	A	187509932	G	A	187509932	2	1	48	1	0	0	0	0	0	0	0	1	5721	1049	37	1		1	FAT1	4	187509932	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	334077	187509932	3644344	1351	5745										
FAT1	2195	broad.mit.edu	37	chr4	187539012	187539012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtggactatcgttgacatCggtgacggtaacatccacaa	11	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:187539012C>T	ENST00000441802.2	-	10	8937	c.8728G>A	c.(8728-8730)Gat>Aat	p.D2910N		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2910	Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCGTTGACATCGGTGACGGTA	0.478										HNSCC(5;0.00058)			12	71					0	0	1	0	0	T	187539012	C	T	187539012	3	4	48	1	0	0	0	0	1	0	0	0	5721	884	31	1	5110	1	FAT1	4	187539012	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29080	187539012	3615264	1352	5746										
FAT1	2195	broad.mit.edu	37	chr4	187542357	187542357	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatcagcatcagctgctcGaatcaccagtgggacattcc	8	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:187542357G>A	ENST00000441802.2	-	10	5592	c.5383C>T	c.(5383-5385)Cga>Tga	p.R1795*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1795	Cadherin 16.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCAGCTGCTCGAATCACCAGT	0.428										HNSCC(5;0.00058)			14	23					0	0	1	0	0	A	187542357	G	A	187542357	4	1	48	1	0	0	0	0	0	1	0	0	5721	1066	37	1	8455	1	FAT1	4	187542357	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3345	187542357	3611919	1353	5747										
TRIML2	205860	broad.mit.edu	37	chr4	189022278	189022278	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcttgattcagaagggtttCtctcaggttcaagtcagata	10	8	5	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:189022278C>A	ENST00000512729.1	-	3	636	c.262G>T	c.(262-264)Gaa>Taa	p.E88*	TRIML2_ENST00000326754.3_Nonsense_Mutation_p.E88*|TRIML2_ENST00000536972.1_Nonsense_Mutation_p.E138*	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	88							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AGAAGGGTTTCTCTCAGGTTC	0.438													13	21					3.27435e-08	3.83577e-08	1	1	0	A	189022278	C	A	189022278	4	1	48	1	0	0	0	0	0	1	0	0	16611	922	32	2	921	2	TRIML2	4	189022278	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1479921	189022278	2131998	1354	5748										
TRIML1	339976	broad.mit.edu	37	chr4	189061694	189061694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgcaggagaaactccagGaaatcctgaatcttttgcgt	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr4:189061694G>A	ENST00000332517.3	+	2	561	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	141					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAAACTCCAGGAAATCCTGAA	0.493													17	35					0	0	1	0	0	A	189061694	G	A	189061694	3	1	48	1	0	0	0	0	1	0	0	0	16610	1175	41	3	427	3	TRIML1	4	189061694	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	39416	189061694	2092582	1355	5749										
SDHA	6389	broad.mit.edu	37	chr5	251454	251454	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaactttttgtgtccccaggAatggtctggaacacggacct	11	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:251454A>G	ENST00000264932.6	+	13	1780	c.1663_splice	c.e13-1	p.G555_splice	SDHA_ENST00000510361.1_Splice_Site_p.G507_splice|SDHA_ENST00000504309.1_Intron	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	555			G -> E (in MT-C2D and CMD1GG).		nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TGTCCCCAGGAATGGTCTGGA	0.607									Familial Paragangliomas				12	27					0	0	1	0	0	G	251454	A	G	251454	5	3	48	1	0	0	0	0	0	0	1	0	14016	260	9	4	1715	4	SDHA	5	251454	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08		251454	180663806	1356	5750										
AHRR	57491	broad.mit.edu	37	chr5	353941	353941	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggccagcctgctgccgttCccgcctgacatcatctccaa	8	18	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:353941C>T	ENST00000316418.5	+	3	215	c.171C>T	c.(169-171)ttC>ttT	p.F57F	AHRR_ENST00000505113.1_Silent_p.F57F|AHRR_ENST00000512529.1_Intron|AHRR_ENST00000515206.1_Silent_p.F53F	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	57	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TGCTGCCGTTCCCGCCTGACA	0.622													20	55					0	0	1	0	0	T	353941	C	T	353941	2	4	48	1	0	0	0	0	0	0	0	1	414	854	30	3		3	AHRR	5	353941	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	102487	353941	180561319	1357	5751										
AHRR	57491	broad.mit.edu	37	chr5	354006	354006	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcagtgtcagttacctccGggtgaagagcttcttccaag	10	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:354006G>A	ENST00000316418.5	+	3	280	c.236G>A	c.(235-237)cGg>cAg	p.R79Q	AHRR_ENST00000505113.1_Missense_Mutation_p.R79Q|AHRR_ENST00000512529.1_Intron|AHRR_ENST00000515206.1_Missense_Mutation_p.R75Q	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	79	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			AGTTACCTCCGGGTGAAGAGC	0.597													22	51					0	0	1	0	0	A	354006	G	A	354006	3	1	48	1	0	0	0	0	1	0	0	0	414	1116	39	1	246	1	AHRR	5	354006	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65	354006	180561254	1358	5752										
SLC12A7	10723	broad.mit.edu	37	chr5	1057651	1057651	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctcctgtacttctcagcGatcagcttctccctggtcca	7	16	3	0	rs139553130		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:1057651G>A	ENST00000264930.5	-	22	3004	c.2961C>T	c.(2959-2961)atC>atT	p.I987I		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	987					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ACTTCTCAGCGATCAGCTTCT	0.612													75	123					0	0	1	0	0	A	1057651	G	A	1057651	2	1	48	1	0	0	0	0	0	0	0	1	14442	1048	37	1		1	SLC12A7	5	1057651	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	703645	1057651	179857609	1359	5753										
SLC6A18	348932	broad.mit.edu	37	chr5	1246126	1246126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagggacgcgcgcccagacaCggacatgcgcccggacacgg	15	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:1246126C>T	ENST00000324642.3	+	12	1943	c.1820C>T	c.(1819-1821)aCg>aTg	p.T607M		NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	607					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGCCCAGACACGGACATGCGC	0.736													3	12					0	0	1	0	0	T	1246126	C	T	1246126	3	4	48	1	0	0	0	0	1	0	0	0	14735	536	19	1	1866	1	SLC6A18	5	1246126	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	188475	1246126	179669134	1360	5754										
SLC6A3	6531	broad.mit.edu	37	chr5	1420693	1420693	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtactcacagacgcctcGcagagccggtagaagtcaac	10	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:1420693G>A	ENST00000270349.9	-	6	1045	c.918C>T	c.(916-918)tgC>tgT	p.C306C	SLC6A3_ENST00000453492.2_Silent_p.C306C	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	306					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CAGACGCCTCGCAGAGCCGGT	0.592													49	88					0	0	1	0	0	A	1420693	G	A	1420693	2	1	48	1	0	0	0	0	0	0	0	1	14739	1079	38	1		1	SLC6A3	5	1420693	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	174567	1420693	179494567	1361	5755										
IRX4	50805	broad.mit.edu	37	chr5	1878497	1878499	+	In_Frame_Del	DEL	GGC	GGC	-													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagtctggctcagggaggtGgcggcggcggcggcggcggt							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:1878497_1878499delGGC	ENST00000505790.1	-	6	1600_1602	c.1144_1146delGCC	c.(1144-1146)del	p.A382del	IRX4_ENST00000231357.2_In_Frame_Del_p.A382del|IRX4_ENST00000513692.1_In_Frame_Del_p.A382del	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	382	Poly-Ala.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		TCAGGGAggtggcggcggcggcg	0.739													2	4	---	---	---	---						-	1878499	GGC	-	1878497	7	5	48	1	0	1	0	1	0	0	0	0	7889	1335	47	0	417	0	IRX4	5	1878497	In_Frame_Del	DEL	GGC	TCGA-ND-A4WC-01A-21D-A28R-08	457804	1878497	179036763	1362	5756										
ADAMTS16	170690	broad.mit.edu	37	chr5	5146327	5146327	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaccatcagcggcggagaaGagcagtgcccgtgtccgagg	16	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:5146327G>T	ENST00000274181.7	+	3	398	c.260G>T	c.(259-261)aGa>aTa	p.R87I	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.R87I|CTD-2297D10.1_ENST00000514848.1_RNA	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	87					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CGGCGGAGAAGAGCAGTGCCC	0.542													18	52					7.07596e-05	7.68259e-05	1	1	0	T	5146327	G	T	5146327	3	4	48	1	0	0	0	0	1	0	0	0	260	942	33	2	270	2	ADAMTS16	5	5146327	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3267830	5146327	175768933	1363	5757										
ADAMTS16	170690	broad.mit.edu	37	chr5	5262810	5262810	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctgctacagagacctgaaGtttcaagtaaatatgtcctt	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:5262810G>T	ENST00000274181.7	+	18	2841	c.2703G>T	c.(2701-2703)aaG>aaT	p.K901N		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	901	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GAGACCTGAAGTTTCAAGTAA	0.502													19	39					3.32936e-07	3.80431e-07	1	1	0	T	5262810	G	T	5262810	3	4	48	1	0	0	0	0	1	0	0	0	260	1020	36	5	2773	5	ADAMTS16	5	5262810	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	116483	5262810	175652450	1364	5758										
NSUN2	54888	broad.mit.edu	37	chr5	6607343	6607343	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctttcttactgccattaTtctctaaatcctcagttgca	3	12	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:6607343T>G	ENST00000264670.6	-	13	1789	c.1478A>C	c.(1477-1479)aAt>aCt	p.N493T	NSUN2_ENST00000539938.1_Missense_Mutation_p.N257T|NSUN2_ENST00000506139.1_Missense_Mutation_p.N458T	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	493						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						ACTGCCATTATTCTCTAAATC	0.438													69	136					0	0	1	0	0	G	6607343	T	G	6607343	3	3	48	1	0	0	0	0	1	0	0	0	10725	1493	52	4	853	4	NSUN2	5	6607343	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1344533	6607343	174307917	1365	5759										
ADCY2	108	broad.mit.edu	37	chr5	7784477	7784477	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctgtctgttttttaataGaccaggcatttggaaagacc	9	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:7784477G>T	ENST00000338316.4	+	19	2473		c.e19-1		ADCY2_ENST00000537121.1_Splice_Site	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TTTTTTAATAGACCAGGCATT	0.393													9	23					3.09899e-07	3.54467e-07	1	1	0	T	7784477	G	T	7784477	5	4	48	1	0	0	0	0	0	0	1	0	293	956	33	2	2458	2	ADCY2	5	7784477	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1177134	7784477	173130783	1366	5760										
ADCY2	108	broad.mit.edu	37	chr5	7817025	7817025	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcaccatggtggagtttgCttttgccctggtagggaagc	15	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:7817025C>A	ENST00000338316.4	+	23	3019	c.2930C>A	c.(2929-2931)gCt>gAt	p.A977D	ADCY2_ENST00000537121.1_Missense_Mutation_p.A797D	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	977					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GTGGAGTTTGCTTTTGCCCTG	0.507											OREG0016499	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	51					5.35267e-07	6.09026e-07	1	1	0	A	7817025	C	A	7817025	3	1	48	1	0	0	0	0	1	0	0	0	293	797	28	5	3020	5	ADCY2	5	7817025	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32548	7817025	173098235	1367	5761										
MTRR	4552	broad.mit.edu	37	chr5	7870968	7870968	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggcaaaggccatcgcagaaGaaatatgtgagcaagctgtg	13	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:7870968G>A	ENST00000264668.2	+	2	172	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K	MTRR_ENST00000440940.2_Missense_Mutation_p.E21K|MTRR_ENST00000502509.1_Intron|MTRR_ENST00000341013.6_Missense_Mutation_p.E21K	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	48	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CATCGCAGAAGAAATATGTGA	0.428													6	62					0	0	1	0	0	A	7870968	G	A	7870968	3	1	48	1	0	0	0	0	1	0	0	0	10008	943	33	3	148	3	MTRR	5	7870968	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53943	7870968	173044292	1368	5762										
MTRR	4552	broad.mit.edu	37	chr5	7873611	7873611	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaacactgccggttgatttCtttgctcacctgcggtatgg	10	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:7873611C>A	ENST00000264668.2	+	3	366	c.336C>A	c.(334-336)ttC>ttA	p.F112L	MTRR_ENST00000440940.2_Missense_Mutation_p.F85L|MTRR_ENST00000502509.1_Intron|MTRR_ENST00000341013.6_Intron	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	112	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CGGTTGATTTCTTTGCTCACC	0.448													30	55					5.77227e-19	7.83808e-19	1	1	0	A	7873611	C	A	7873611	3	1	48	1	0	0	0	0	1	0	0	0	10008	912	32	2	346	2	MTRR	5	7873611	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2643	7873611	173041649	1369	5763										
SEMA5A	9037	broad.mit.edu	37	chr5	9154778	9154778	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttgaggtctgattcagggGtacccgcactttcttaatgg	12	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:9154778G>A	ENST00000382496.5	-	12	1968	c.1303C>T	c.(1303-1305)Ccc>Tcc	p.P435S		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	435	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TGATTCAGGGGTACCCGCACT	0.512													35	54					0	0	1	0	0	A	9154778	G	A	9154778	3	1	48	1	0	0	0	0	1	0	0	0	14090	1261	44	3	1969	3	SEMA5A	5	9154778	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1281167	9154778	171760482	1370	5764										
CTNND2	1501	broad.mit.edu	37	chr5	11018149	11018149	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaggacctgagatgcagcCttgaccacttttggagagtg	13	8	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:11018149C>T	ENST00000304623.8	-	18	3210	c.3021G>A	c.(3019-3021)aaG>aaA	p.K1007K	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Silent_p.K916K|CTNND2_ENST00000458100.2_Silent_p.K574K|CTNND2_ENST00000359640.2_Silent_p.K949K|CTNND2_ENST00000503622.1_Silent_p.K670K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1007					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GAGATGCAGCCTTGACCACTT	0.473													7	35					0	0	1	0	0	T	11018149	C	T	11018149	2	4	48	1	0	0	0	0	0	0	0	1	4044	680	24	3		3	CTNND2	5	11018149	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1863371	11018149	169897111	1371	5765										
DNAH5	1767	broad.mit.edu	37	chr5	13753382	13753382	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttatttttaatccagatcTtgccttgagtctgtggatca	7	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:13753382T>C	ENST00000265104.4	-	63	10936	c.10832A>G	c.(10831-10833)aAg>aGg	p.K3611R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3611	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AATCCAGATCTTGCCTTGAGT	0.368									Kartagener syndrome				21	38					0	0	1	0	0	C	13753382	T	C	13753382	3	2	48	1	0	0	0	0	1	0	0	0	4632	1609	56	4	3110	4	DNAH5	5	13753382	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2735233	13753382	167161878	1372	5766										
DNAH5	1767	broad.mit.edu	37	chr5	13753429	13753429	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagggtaacgagatgccttCgtgacaataattccattttg	9	7	0	2	rs144055129		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:13753429C>T	ENST00000265104.4	-	63	10889	c.10785G>A	c.(10783-10785)acG>acA	p.T3595T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3595	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GAGATGCCTTCGTGACAATAA	0.383									Kartagener syndrome				5	59					0	0	1	0	0	T	13753429	C	T	13753429	2	4	48	1	0	0	0	0	0	0	0	1	4632	871	31	1		1	DNAH5	5	13753429	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47	13753429	167161831	1373	5767										
DNAH5	1767	broad.mit.edu	37	chr5	13766094	13766094	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaactaccaacctgtaagttCtgtaaaaagttccctgcagt	7	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:13766094C>T	ENST00000265104.4	-	59	10196	c.10092G>A	c.(10090-10092)caG>caA	p.Q3364Q	DNAH5_ENST00000504001.3_Intron	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3364	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTGTAAGTTCTGTAAAAAGT	0.408									Kartagener syndrome				45	69					0	0	1	0	0	T	13766094	C	T	13766094	2	4	48	1	0	0	0	0	0	0	0	1	4632	912	32	3		3	DNAH5	5	13766094	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12665	13766094	167149166	1374	5768										
DNAH5	1767	broad.mit.edu	37	chr5	13866373	13866373	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttcctggggcttcaagcCgctagccattggaccattct	11	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:13866373C>T	ENST00000265104.4	-	26	4176	c.4072G>A	c.(4072-4074)Ggc>Agc	p.G1358S	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1358	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGCTTCAAGCCGCTAGCCATT	0.318									Kartagener syndrome				10	12					0	0	1	0	0	T	13866373	C	T	13866373	3	4	48	1	0	0	0	0	1	0	0	0	4632	652	23	1	10018	1	DNAH5	5	13866373	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	100279	13866373	167048887	1375	5769										
DNAH5	1767	broad.mit.edu	37	chr5	13871097	13871097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttgtctcagcagtcagggCgaacttcaagtcagctgtaa	10	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:13871097C>T	ENST00000265104.4	-	24	3717	c.3613G>A	c.(3613-3615)Gcc>Acc	p.A1205T	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1205	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCAGTCAGGGCGAACTTCAAG	0.403									Kartagener syndrome				14	36					0	0	1	0	0	T	13871097	C	T	13871097	3	4	48	1	0	0	0	0	1	0	0	0	4632	768	27	1	10485	1	DNAH5	5	13871097	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4724	13871097	167044163	1376	5770										
FAM105A	54491	broad.mit.edu	37	chr5	14607452	14607452	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcaagcttcctgaaaaacTgctgttttcacaaggttgta	7	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:14607452T>C	ENST00000274217.3	+	6	632	c.512T>C	c.(511-513)cTg>cCg	p.L171P		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	171										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					CCTGAAAAACTGCTGTTTTCA	0.378													23	35					0	0	1	0	0	C	14607452	T	C	14607452	3	2	48	1	0	0	0	0	1	0	0	0	5418	1580	55	4	534	4	FAM105A	5	14607452	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	736355	14607452	166307808	1377	5771										
FAM105B	90268	broad.mit.edu	37	chr5	14690293	14690293	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattgaactatataatgataAagagaaaggaaaggaagtac	9	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:14690293A>T	ENST00000284274.4	+	6	818	c.740A>T	c.(739-741)aAa>aTa	p.K247I		NM_138348.4	NP_612357.4	Q96BN8	F105B_HUMAN	family with sequence similarity 105, member B	247										breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	14	Lung NSC(4;0.00696)					TATAATGATAAAGAGAAAGGA	0.413													16	31					0	0	1	0	0	T	14690293	A	T	14690293	3	4	48	1	0	0	0	0	1	0	0	0	5419	14	1	4	762	4	FAM105B	5	14690293	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	82841	14690293	166224967	1378	5772										
MYO10	4651	broad.mit.edu	37	chr5	16701878	16701878	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctgtttctccagttcacGggtcagttcagcttccttct	7	13	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:16701878G>A	ENST00000513610.1	-	25	3080	c.2626C>T	c.(2626-2628)Cgt>Tgt	p.R876C	MYO10_ENST00000427430.2_Missense_Mutation_p.R233C|MYO10_ENST00000505695.1_Missense_Mutation_p.R215C|MYO10_ENST00000274203.9_Missense_Mutation_p.R233C|MYO10_ENST00000515803.1_Missense_Mutation_p.R215C	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	876					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TCCAGTTCACGGGTCAGTTCA	0.507													15	30					0	0	1	0	0	A	16701878	G	A	16701878	3	1	48	1	0	0	0	0	1	0	0	0	10109	1116	39	1	3618	1	MYO10	5	16701878	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2011585	16701878	164213382	1379	5773										
PRDM9	56979	broad.mit.edu	37	chr5	23522975	23522975	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagacgaagaggcagccaAcaatggatactcctggctgg	13	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:23522975A>G	ENST00000296682.3	+	8	1045	c.863A>G	c.(862-864)aAc>aGc	p.N288S		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	288	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GAGGCAGCCAACAATGGATAC	0.527										HNSCC(3;0.000094)			38	71					0	0	1	0	0	G	23522975	A	G	23522975	3	3	48	1	0	0	0	0	1	0	0	0	12514	43	2	4	889	4	PRDM9	5	23522975	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6821097	23522975	157392285	1380	5774										
CDH10	1008	broad.mit.edu	37	chr5	24509887	24509887	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatgggtgttttctgcttcGactttcagagtataaagtct	9	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:24509887G>A	ENST00000264463.4	-	7	1551	c.1044C>T	c.(1042-1044)gtC>gtT	p.V348V		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	348	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTTCTGCTTCGACTTTCAGAG	0.378										HNSCC(23;0.051)			12	18					0	0	1	0	0	A	24509887	G	A	24509887	2	1	48	1	0	0	0	0	0	0	0	1	3118	1045	37	1		1	CDH10	5	24509887	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	986912	24509887	156405373	1381	5775										
CDH10	1008	broad.mit.edu	37	chr5	24535873	24535873	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgctgtaaatgactctggcGctgttcccatatgaagggtc	11	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:24535873G>A	ENST00000264463.4	-	4	1092	c.585C>T	c.(583-585)agC>agT	p.S195S		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	195	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S195R(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGACTCTGGCGCTGTTCCCAT	0.453										HNSCC(23;0.051)			16	24					0	0	1	0	0	A	24535873	G	A	24535873	2	1	48	1	0	0	0	0	0	0	0	1	3118	1078	38	1		1	CDH10	5	24535873	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25986	24535873	156379387	1382	5776										
PDZD2	23037	broad.mit.edu	37	chr5	32088777	32088777	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacatgacctgctagatgaCgaaaccctgaatcaatacga	8	10	1	4	rs74814525	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:32088777C>T	ENST00000438447.1	+	20	5611	c.5223C>T	c.(5221-5223)gaC>gaT	p.D1741D	PDZD2_ENST00000282493.3_Silent_p.D1741D			O15018	PDZD2_HUMAN	PDZ domain containing 2	1741					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TGCTAGATGACGAAACCCTGA	0.473													32	56					0	0	1	0	0	T	32088777	C	T	32088777	2	4	48	1	0	0	0	0	0	0	0	1	11747	535	19	1		1	PDZD2	5	32088777	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7552904	32088777	148826483	1383	5777										
ZFR	51663	broad.mit.edu	37	chr5	32403220	32403220	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagtacttgccaacaaaatTtattttgggggtagatgttt	9	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:32403220T>A	ENST00000265069.8	-	8	1609	c.1507A>T	c.(1507-1509)Aat>Tat	p.N503Y		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	503					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		CCAACAAAATTTATTTTGGGG	0.418													23	33					0	0	1	0	0	A	32403220	T	A	32403220	3	1	48	1	0	0	0	0	1	0	0	0	17716	1841	64	4	1769	4	ZFR	5	32403220	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	314443	32403220	148512040	1384	5778										
ZFR	51663	broad.mit.edu	37	chr5	32404114	32404114	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattttgagtcccacgagtaGaactgttgctgctgctggta	12	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:32404114G>T	ENST00000265069.8	-	7	1223	c.1121C>A	c.(1120-1122)tCt>tAt	p.S374Y		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	374					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		CCCACGAGTAGAACTGTTGCT	0.423													20	53					0.000132079	0.000142521	1	1	0	T	32404114	G	T	32404114	3	4	48	1	0	0	0	0	1	0	0	0	17716	942	33	2	2159	2	ZFR	5	32404114	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	894	32404114	148511146	1385	5779										
NPR3	4883	broad.mit.edu	37	chr5	32786419	32786419	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatcgggaattacgggaaGattccatcagatcccatttt	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:32786419G>A	ENST00000265074.8	+	8	1937	c.1594G>A	c.(1594-1596)Gat>Aat	p.D532N	NPR3_ENST00000415167.2_Missense_Mutation_p.D531N|NPR3_ENST00000415685.2_Missense_Mutation_p.D315N|NPR3_ENST00000434067.2_Missense_Mutation_p.D316N	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	532					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	ATTACGGGAAGATTCCATCAG	0.413													5	13					0	0	1	0	0	A	32786419	G	A	32786419	3	1	48	1	0	0	0	0	1	0	0	0	10643	942	33	3	1621	3	NPR3	5	32786419	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	382305	32786419	148128841	1386	5780										
TARS	6897	broad.mit.edu	37	chr5	33467054	33467054	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtacattgaataaaaagattCgaaatgcacagttagcacag	8	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:33467054C>T	ENST00000265112.3	+	18	2298	c.1987C>T	c.(1987-1989)Cga>Tga	p.R663*	TARS_ENST00000502553.1_Nonsense_Mutation_p.R663*|TARS_ENST00000455217.2_Nonsense_Mutation_p.R696*|TARS_ENST00000414361.2_Nonsense_Mutation_p.R542*|TARS_ENST00000541634.1_Nonsense_Mutation_p.R559*	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	663					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity	p.R663*(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TAAAAAGATTCGAAATGCACA	0.373													15	32					0	0	1	0	0	T	33467054	C	T	33467054	4	4	48	1	0	0	0	0	0	1	0	0	15615	876	31	1	2057	1	TARS	5	33467054	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	680635	33467054	147448206	1387	5781										
RXFP3	51289	broad.mit.edu	37	chr5	33937052	33937052	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacatcccccgggcagcggCggggcagagagcgcggacac	18	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:33937052C>T	ENST00000330120.3	+	1	562	c.207C>T	c.(205-207)ggC>ggT	p.G69G		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	69						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CGGGCAGCGGCGGGGCAGAGA	0.697													30	44					0	0	1	0	0	T	33937052	C	T	33937052	2	4	48	1	0	0	0	0	0	0	0	1	13812	755	27	1		1	RXFP3	5	33937052	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	469998	33937052	146978208	1388	5782										
AMACR	23600	broad.mit.edu	37	chr5	34005876	34005876	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catacctgacaaagccaaatAgttgatatcgtggccagcta	8	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:34005876A>T	ENST00000335606.6	-	2	464	c.376T>A	c.(376-378)Tat>Aat	p.Y126N	AMACR_ENST00000514195.1_5'UTR|AMACR_ENST00000441713.2_Missense_Mutation_p.Y126N|AMACR_ENST00000502637.1_Missense_Mutation_p.Y126N|AMACR_ENST00000382085.3_Missense_Mutation_p.Y126N|AMACR_ENST00000382072.2_Missense_Mutation_p.Y126N	NM_001167595.1|NM_014324.5	NP_001161067.1|NP_055139.4	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase	126					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	19						AAAGCCAAATAGTTGATATCG	0.388													24	38					0	0	1	0	0	T	34005876	A	T	34005876	3	4	48	1	0	0	0	0	1	0	0	0	558	420	15	4	1118	4	AMACR	5	34005876	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	68824	34005876	146909384	1389	5783										
SPEF2	79925	broad.mit.edu	37	chr5	35763639	35763639	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagaattcctctagttccTcgaatatccatttctctgga	5	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:35763639T>C	ENST00000440995.2	+	26	3621	c.3621T>C	c.(3619-3621)ccT>ccC	p.P1207P	SPEF2_ENST00000356031.3_Silent_p.P1212P|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1212					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTCTAGTTCCTCGAATATCCA	0.333													13	29					0	0	1	0	0	C	35763639	T	C	35763639	2	2	48	1	0	0	0	0	0	0	0	1	15090	1538	54	4		4	SPEF2	5	35763639	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1757763	35763639	145151621	1390	5784										
SPEF2	79925	broad.mit.edu	37	chr5	35771815	35771815	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgcaaataaaaaagtcaaAaaggagccacccaagaaaaa	8	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:35771815A>C	ENST00000440995.2	+	27	3891	c.3891A>C	c.(3889-3891)aaA>aaC	p.K1297N	SPEF2_ENST00000356031.3_Missense_Mutation_p.K1302N|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1302					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAAAGTCAAAAAGGAGCCAC	0.408													3	27					0	0	1	0	0	C	35771815	A	C	35771815	3	2	48	1	0	0	0	0	1	0	0	0	15090	11	1	4	4033	4	SPEF2	5	35771815	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	8176	35771815	145143445	1391	5785										
IL7R	3575	broad.mit.edu	37	chr5	35860991	35860991	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaactggatgactactcattCtcatgctatagccagttgga	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:35860991C>T	ENST00000303115.3	+	2	249	c.120C>T	c.(118-120)ttC>ttT	p.F40F	IL7R_ENST00000343305.4_Silent_p.F40F|IL7R_ENST00000511982.1_Silent_p.F40F|IL7R_ENST00000511031.1_3'UTR|IL7R_ENST00000506850.1_Silent_p.F40F	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	40					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ACTACTCATTCTCATGCTATA	0.423			"Mis, O"		"ALL, ETP ALL"		Severe combined immune deficiency						19	94					0	0	1	0	0	T	35860991	C	T	35860991	2	4	48	1	0	0	0	0	0	0	0	1	7748	912	32	3		3	IL7R	5	35860991	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	89176	35860991	145054269	1392	5786										
CAPSL	133690	broad.mit.edu	37	chr5	35910012	35910012	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaaagttatccagaaattTcctaaatacttgttcctcac	3	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:35910012T>G	ENST00000397367.2	-	4	607	c.481A>C	c.(481-483)Aaa>Caa	p.K161Q	CAPSL_ENST00000397366.1_Missense_Mutation_p.K161Q|CAPSL_ENST00000514524.1_Missense_Mutation_p.K161Q	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	161	EF-hand 4.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TCCAGAAATTTCCTAAATACT	0.368													12	75					0	0	1	0	0	G	35910012	T	G	35910012	3	3	48	1	0	0	0	0	1	0	0	0	2657	1792	62	4	153	4	CAPSL	5	35910012	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	49021	35910012	145005248	1393	5787										
NIPBL	25836	broad.mit.edu	37	chr5	36955610	36955610	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttccatctcctttacctgCtacaactacaaagagccttc	3	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:36955610C>A	ENST00000282516.8	+	3	600	c.101C>A	c.(100-102)gCt>gAt	p.A34D	NIPBL_ENST00000448238.2_Missense_Mutation_p.A34D	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	34					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CCTTTACCTGCTACAACTACA	0.398													15	34					1.33834e-09	1.61283e-09	1	1	0	A	36955610	C	A	36955610	3	1	48	1	0	0	0	0	1	0	0	0	10474	797	28	5	107	5	NIPBL	5	36955610	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1045598	36955610	143959650	1394	5788										
C5orf42	65250	broad.mit.edu	37	chr5	37198935	37198935	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccttctggcgattattttTttcagcttttaaaagaagat	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:37198935T>G	ENST00000274258.7	-	20	3771	c.184A>C	c.(184-186)Aaa>Caa	p.K62Q	C5orf42_ENST00000425232.2_Missense_Mutation_p.K1181Q|C5orf42_ENST00000508244.1_Missense_Mutation_p.K1181Q			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1181										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CGATTATTTTTTTCAGCTTTT	0.368													4	38					0	0	1	0	0	G	37198935	T	G	37198935	3	3	48	1	0	0	0	0	1	0	0	0	2316	1850	64	4	6184	4	C5orf42	5	37198935	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	243325	37198935	143716325	1395	5789										
C9	735	broad.mit.edu	37	chr5	39341372	39341372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcattgtcaccattacaccGaagtcgcatctttatgcatc	6	12	3	0	rs147701327		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:39341372G>A	ENST00000263408.4	-	4	447	c.352C>T	c.(352-354)Cgg>Tgg	p.R118W	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	118	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CCATTACACCGAAGTCGCATC	0.428													34	62					0	0	1	0	0	A	39341372	G	A	39341372	3	1	48	1	0	0	0	0	1	0	0	0	2461	1057	37	1	1359	1	C9	5	39341372	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2142437	39341372	141573888	1396	5790										
DAB2	1601	broad.mit.edu	37	chr5	39392476	39392476	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaattcttaccccagttttCtcatcaattatttttatccc	2	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:39392476C>A	ENST00000320816.6	-	4	788	c.321G>T	c.(319-321)gaG>gaT	p.E107D	DAB2_ENST00000545653.1_Missense_Mutation_p.E107D|DAB2_ENST00000339788.6_Missense_Mutation_p.E107D|DAB2_ENST00000512525.1_5'UTR|DAB2_ENST00000509337.1_Missense_Mutation_p.E107D	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	107	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			CCCCAGTTTTCTCATCAATTA	0.458													10	16					9.70103e-10	1.17791e-09	1	1	0	A	39392476	C	A	39392476	3	1	48	1	0	0	0	0	1	0	0	0	4242	912	32	2	2035	2	DAB2	5	39392476	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	51104	39392476	141522784	1397	5791										
TTC33	23548	broad.mit.edu	37	chr5	40730378	40730378	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattacctgtgatttcatctCgtatagggtagcatcatttg	8	7	3	1	rs144481517	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:40730378C>T	ENST00000337702.4	-	3	441	c.289G>A	c.(289-291)Gag>Aag	p.E97K	TTC33_ENST00000503936.2_Intron	NM_012382.2	NP_036514.1	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	97							binding			NS(1)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|urinary_tract(1)	11						GATTTCATCTCGTATAGGGTA	0.358													19	34					0	0	1	0	0	T	40730378	C	T	40730378	3	4	48	1	0	0	0	0	1	0	0	0	16763	893	31	1	511	1	TTC33	5	40730378	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1337902	40730378	140184882	1398	5792										
C7	730	broad.mit.edu	37	chr5	40959686	40959686	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgttggagaaacgacagaaaGcacacaatgcgaagatgagg	13	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:40959686G>A	ENST00000313164.9	+	12	1984	c.1625G>A	c.(1624-1626)aGc>aAc	p.S542N		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	542	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				ACGACAGAAAGCACACAATGC	0.537													14	22					0	0	1	0	0	A	40959686	G	A	40959686	3	1	48	1	0	0	0	0	1	0	0	0	2391	971	34	3	1671	3	C7	5	40959686	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	229308	40959686	139955574	1399	5793										
PLCXD3	345557	broad.mit.edu	37	chr5	41313764	41313764	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagacatagttgagctttatGacagtgctgataaagtcacc	9	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:41313764G>T	ENST00000377801.3	-	3	995	c.921C>A	c.(919-921)gtC>gtA	p.V307V	PLCXD3_ENST00000328457.3_Silent_p.V307V			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	307					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TGAGCTTTATGACAGTGCTGA	0.448													15	32					7.93312e-07	8.98086e-07	1	1	0	T	41313764	G	T	41313764	2	4	48	1	0	0	0	0	0	0	0	1	12090	1277	45	2		2	PLCXD3	5	41313764	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	354078	41313764	139601496	1400	5794										
PLCXD3	345557	broad.mit.edu	37	chr5	41382489	41382489	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctcctagctggccagtaAaattcattgtctgagtggct	10	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:41382489A>C	ENST00000377801.3	-	2	325	c.251T>G	c.(250-252)tTt>tGt	p.F84C	PLCXD3_ENST00000328457.3_Missense_Mutation_p.F84C			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	84	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						CTGGCCAGTAAAATTCATTGT	0.453													20	31					0	0	1	0	0	C	41382489	A	C	41382489	3	2	48	1	0	0	0	0	1	0	0	0	12090	14	1	4	722	4	PLCXD3	5	41382489	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	68725	41382489	139532771	1401	5795										
OXCT1	5019	broad.mit.edu	37	chr5	41794170	41794170	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctcctagcattgtcagatCgacgtgtccactgagaaaga	10	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:41794170C>T	ENST00000196371.5	-	13	1343	c.1183G>A	c.(1183-1185)Gat>Aat	p.D395N	OXCT1_ENST00000513081.1_5'UTR|OXCT1_ENST00000510634.1_5'UTR|OXCT1_ENST00000512084.1_5'UTR|OXCT1_ENST00000509987.1_Missense_Mutation_p.D209N	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	395					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	ATTGTCAGATCGACGTGTCCA	0.398													9	81					0	0	1	0	0	T	41794170	C	T	41794170	3	4	48	1	0	0	0	0	1	0	0	0	11375	884	31	1	399	1	OXCT1	5	41794170	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	411681	41794170	139121090	1402	5796										
PARP8	79668	broad.mit.edu	37	chr5	50090965	50090965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaatgcctaactctaaagtCgcatagactattgactcgat	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:50090965C>T	ENST00000281631.5	+	12	1300	c.1142C>T	c.(1141-1143)tCg>tTg	p.S381L	PARP8_ENST00000505554.1_Missense_Mutation_p.S360L|PARP8_ENST00000503750.2_Missense_Mutation_p.S381L|PARP8_ENST00000514342.2_Missense_Mutation_p.S134L|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.S381L|PARP8_ENST00000514067.2_Missense_Mutation_p.S381L	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	381						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				ACTCTAAAGTCGCATAGACTA	0.458													27	68					0	0	1	0	0	T	50090965	C	T	50090965	3	4	48	1	0	0	0	0	1	0	0	0	11511	893	31	1	1188	1	PARP8	5	50090965	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8296795	50090965	130824295	1403	5797										
PELO	53918	broad.mit.edu	37	chr5	52096521	52096521	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagtatgtcaagatgggggCttaccacaccatcgagctgg	13	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:52096521C>T	ENST00000274311.2	+	2	1278	c.293C>T	c.(292-294)gCt>gTt	p.A98V	PELO_ENST00000506949.1_Intron|ITGA1_ENST00000504086.1_Intron|ITGA1_ENST00000282588.6_Intron	NM_015946.4	NP_057030.3	Q9BRX2	PELO_HUMAN	pelota homolog (Drosophila)	98					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	11		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				AAGATGGGGGCTTACCACACC	0.582													23	34					0	0	1	0	0	T	52096521	C	T	52096521	3	4	48	1	0	0	0	0	1	0	0	0	11770	797	28	3	295	3	PELO	5	52096521	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2005556	52096521	128818739	1404	5798										
ITGA1	3672	broad.mit.edu	37	chr5	52211328	52211328	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggggatggtaagacactgaAattttttggccagtctatcc	11	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:52211328A>C	ENST00000282588.6	+	15	2350	c.1892A>C	c.(1891-1893)aAa>aCa	p.K631T		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	631					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				AAGACACTGAAATTTTTTGGC	0.423													39	63					0	0	1	0	0	C	52211328	A	C	52211328	3	2	48	1	0	0	0	0	1	0	0	0	7915	14	1	4	1950	4	ITGA1	5	52211328	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	114807	52211328	128703932	1405	5799										
ITGA2	3673	broad.mit.edu	37	chr5	52347299	52347299	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttaacttgaacacatataAaaccaaagaagaaatgattg	6	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:52347299A>C	ENST00000296585.5	+	7	832	c.689A>C	c.(688-690)aAa>aCa	p.K230T		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	230	VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AACACATATAAAACCAAAGAA	0.378													17	30					0	0	1	0	0	C	52347299	A	C	52347299	3	2	48	1	0	0	0	0	1	0	0	0	7918	14	1	4	715	4	ITGA2	5	52347299	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	135971	52347299	128567961	1406	5800										
FST	10468	broad.mit.edu	37	chr5	52780019	52780019	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcttcctctgagcaatatcTctgtgggaatgatggagtca	11	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:52780019T>C	ENST00000396947.3	+	4	783	c.617T>C	c.(616-618)cTc>cCc	p.L206P	FST_ENST00000256759.3_Missense_Mutation_p.L206P	NM_006350.3	NP_006341.1	P19883	FST_HUMAN	follistatin	206	Kazal-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity			breast(1)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|urinary_tract(1)	15		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				GAGCAATATCTCTGTGGGAAT	0.522													24	44					0	0	1	0	0	C	52780019	T	C	52780019	3	2	48	1	0	0	0	0	1	0	0	0	6110	1551	54	4	631	4	FST	5	52780019	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	432720	52780019	128135241	1407	5801										
HSPB3	8988	broad.mit.edu	37	chr5	53751869	53751869	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtccagttcctccctgaaGacatcatcattcagaccttc	6	14	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:53751869G>T	ENST00000302005.1	+	1	425	c.250G>T	c.(250-252)Gac>Tac	p.D84Y		NM_006308.2	NP_006299.1	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	84					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus				breast(1)|large_intestine(4)|prostate(3)	8		Lung NSC(810;0.00104)				CCTCCCTGAAGACATCATCAT	0.537													36	89					1.36161e-19	1.85609e-19	1	1	0	T	53751869	G	T	53751869	3	4	48	1	0	0	0	0	1	0	0	0	7463	942	33	2	252	2	HSPB3	5	53751869	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	971850	53751869	127163391	1408	5802										
GZMK	3003	broad.mit.edu	37	chr5	54329702	54329702	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatctacaccctgttaaccaAgaaataccagacttggatca	5	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:54329702A>C	ENST00000231009.2	+	5	813	c.743A>C	c.(742-744)aAg>aCg	p.K248T	CTD-2313F11.1_ENST00000595218.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	248	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTGTTAACCAAGAAATACCAG	0.423													8	38					0	0	1	0	0	C	54329702	A	C	54329702	3	2	48	1	0	0	0	0	1	0	0	0	6958	72	3	4	761	4	GZMK	5	54329702	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	577833	54329702	126585558	1409	5803										
SKIV2L2	23517	broad.mit.edu	37	chr5	54640967	54640967	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atactgcaatgcaagtgcttCgagatgcaggtgatttggcc	12	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:54640967C>T	ENST00000230640.5	+	10	1305	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	SKIV2L2_ENST00000545714.1_Nonsense_Mutation_p.R250*	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	351					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				GCAAGTGCTTCGAGATGCAGG	0.358													8	18					0	0	1	0	0	T	54640967	C	T	54640967	4	4	48	1	0	0	0	0	0	1	0	0	14414	876	31	1	1089	1	SKIV2L2	5	54640967	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	311265	54640967	126274293	1410	5804										
SLC38A9	153129	broad.mit.edu	37	chr5	54931420	54931420	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgaaggaaatgaagcaaaAaccaggactccaatatagag	11	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:54931420A>C	ENST00000539768.1	-	11	1232	c.1233T>G	c.(1231-1233)gtT>gtG	p.V411V	SLC38A9_ENST00000396865.2_Silent_p.V411V|SLC38A9_ENST00000416547.2_Silent_p.V287V|SLC38A9_ENST00000318672.3_Silent_p.V411V|SLC38A9_ENST00000512595.1_Silent_p.V348V|SLC38A9_ENST00000515629.1_Silent_p.V348V			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	411					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				ATGAAGCAAAAACCAGGACTC	0.388													23	33					0	0	1	0	0	C	54931420	A	C	54931420	2	2	48	1	0	0	0	0	0	0	0	1	14665	1	1	4		4	SLC38A9	5	54931420	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	290453	54931420	125983840	1411	5805										
SLC38A9	153129	broad.mit.edu	37	chr5	54948368	54948368	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actacttacctaggatattaAattttgaaaaaaatgaagga	6	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:54948368A>C	ENST00000539768.1	-	8	940	c.941T>G	c.(940-942)tTt>tGt	p.F314C	SLC38A9_ENST00000396865.2_Missense_Mutation_p.F314C|SLC38A9_ENST00000416547.2_Missense_Mutation_p.F190C|SLC38A9_ENST00000318672.3_Missense_Mutation_p.F314C|SLC38A9_ENST00000512595.1_Missense_Mutation_p.F287C|SLC38A9_ENST00000515629.1_Missense_Mutation_p.F251C			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	314					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				TAGGATATTAAATTTTGAAAA	0.403													6	16					0	0	1	0	0	C	54948368	A	C	54948368	3	2	48	1	0	0	0	0	1	0	0	0	14665	14	1	4	772	4	SLC38A9	5	54948368	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	16948	54948368	125966892	1412	5806										
DDX4	54514	broad.mit.edu	37	chr5	55076927	55076927	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagacgaatgtatgcagcGcactggtggcctttttggtt	12	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:55076927G>A	ENST00000505374.1	+	9	622	c.530G>A	c.(529-531)cGc>cAc	p.R177H	DDX4_ENST00000354991.5_Missense_Mutation_p.R143H|DDX4_ENST00000514278.2_Missense_Mutation_p.R157H|DDX4_ENST00000511853.1_Missense_Mutation_p.R44H|DDX4_ENST00000353507.5_Missense_Mutation_p.R143H	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	177	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGTATGCAGCGCACTGGTGGC	0.338													14	34					0	0	1	0	0	A	55076927	G	A	55076927	3	1	48	1	0	0	0	0	1	0	0	0	4383	1087	38	1	601	1	DDX4	5	55076927	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	128559	55076927	125838333	1413	5807										
DDX4	54514	broad.mit.edu	37	chr5	55081645	55081645	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaggcataaacttcgacaaAtacgacactattcttgtgga	7	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:55081645A>C	ENST00000505374.1	+	13	902	c.810A>C	c.(808-810)aaA>aaC	p.K270N	DDX4_ENST00000354991.5_Missense_Mutation_p.K236N|DDX4_ENST00000514278.2_Missense_Mutation_p.K250N|DDX4_ENST00000511853.1_Missense_Mutation_p.K121N|DDX4_ENST00000353507.5_Missense_Mutation_p.K236N	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	270					multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ACTTCGACAAATACGACACTA	0.428													13	29					0	0	1	0	0	C	55081645	A	C	55081645	3	2	48	1	0	0	0	0	1	0	0	0	4383	98	4	4	897	4	DDX4	5	55081645	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4718	55081645	125833615	1414	5808										
DDX4	54514	broad.mit.edu	37	chr5	55109548	55109548	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaactaagaaaaaagcagatTttattgcaacttttctttgt	5	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:55109548T>G	ENST00000505374.1	+	19	1755	c.1663T>G	c.(1663-1665)Ttt>Gtt	p.F555V	DDX4_ENST00000354991.5_Missense_Mutation_p.F521V|DDX4_ENST00000514278.2_Missense_Mutation_p.F535V|DDX4_ENST00000511853.1_Missense_Mutation_p.F406V|DDX4_ENST00000353507.5_Missense_Mutation_p.F521V	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	555	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				AAAAGCAGATTTTATTGCAAC	0.289													42	61					0	0	1	0	0	G	55109548	T	G	55109548	3	3	48	1	0	0	0	0	1	0	0	0	4383	1841	64	4	1774	4	DDX4	5	55109548	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	27903	55109548	125805712	1415	5809										
IL31RA	133396	broad.mit.edu	37	chr5	55195809	55195809	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatggtactatccagaaagCaacactaacctcacagaaac	5	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:55195809C>T	ENST00000396834.1	+	10	1357	c.861C>T	c.(859-861)agC>agT	p.S287S	IL31RA_ENST00000396836.2_Silent_p.S306S|IL31RA_ENST00000447346.2_Silent_p.S306S|IL31RA_ENST00000490985.1_Silent_p.S164S|IL31RA_ENST00000354961.4_Silent_p.S287S|IL31RA_ENST00000359040.5_Silent_p.S306S|IL31RA_ENST00000297015.3_Silent_p.S164S	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	274	Fibronectin type-III 3.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATCCAGAAAGCAACACTAACC	0.413													47	70					0	0	1	0	0	T	55195809	C	T	55195809	2	4	48	1	0	0	0	0	0	0	0	1	7734	709	25	3		3	IL31RA	5	55195809	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	86261	55195809	125719451	1416	5810										
GPBP1	65056	broad.mit.edu	37	chr5	56545382	56545382	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaggaacatgaagatgaAagccgtgctggctcagagaa	14	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:56545382A>G	ENST00000424459.3	+	10	2285	c.1011A>G	c.(1009-1011)gaA>gaG	p.E337E	GPBP1_ENST00000506184.2_Silent_p.E317E|GPBP1_ENST00000511209.1_Silent_p.E309E|GPBP1_ENST00000514387.2_Silent_p.E146E|GPBP1_ENST00000538707.1_Silent_p.E324E|GPBP1_ENST00000264779.6_Silent_p.E324E|GPBP1_ENST00000454432.2_Silent_p.E337E	NM_022913.3	NP_075064.1	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	19		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		ATGAAGATGAAAGCCGTGCTG	0.373													21	26					0	0	1	0	0	G	56545382	A	G	56545382	2	3	48	1	0	0	0	0	0	0	0	1	6634	11	1	4		4	GPBP1	5	56545382	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1349573	56545382	124369878	1417	5811										
ELOVL7	79993	broad.mit.edu	37	chr5	60053346	60053346	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattactcacaagctgtaatGatgtcaaatattttttccac	4	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:60053346G>T	ENST00000505959.1	-	10	1113	c.587C>A	c.(586-588)tCa>tAa	p.S196*	ELOVL7_ENST00000438340.1_Nonsense_Mutation_p.S209*|ELOVL7_ENST00000508821.1_Nonsense_Mutation_p.S209*|ELOVL7_ENST00000425382.1_Nonsense_Mutation_p.S209*			A1L3X0	ELOV7_HUMAN	ELOVL fatty acid elongase 7	209					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	9		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				AAGCTGTAATGATGTCAAATA	0.353													18	45					1.33834e-09	1.61283e-09	1	1	0	T	60053346	G	T	60053346	4	4	48	1	0	0	0	0	0	1	0	0	5107	1294	45	2	227	2	ELOVL7	5	60053346	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3507964	60053346	120861914	1418	5812										
CENPK	64105	broad.mit.edu	37	chr5	64814413	64814413	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccaaaaggaatcactaatTttgacatatggatcatgtgg	10	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:64814413T>G	ENST00000396679.1	-	11	913	c.699A>C	c.(697-699)aaA>aaC	p.K233N	CENPK_ENST00000514814.1_Missense_Mutation_p.K233N|CENPK_ENST00000510693.1_Missense_Mutation_p.K170N|CENPK_ENST00000508421.1_Missense_Mutation_p.K203N|CENPK_ENST00000506282.2_5'UTR|CENPK_ENST00000242872.3_Missense_Mutation_p.K233N	NM_022145.4	NP_071428.2	Q9BS16	CENPK_HUMAN	centromere protein K	233					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|endometrium(1)|large_intestine(3)|lung(5)	10		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		AATCACTAATTTTGACATATG	0.343													17	34					0	0	1	0	0	G	64814413	T	G	64814413	3	3	48	1	0	0	0	0	1	0	0	0	3257	1838	64	4	114	4	CENPK	5	64814413	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4761067	64814413	116100847	1419	5813										
TRIM23	373	broad.mit.edu	37	chr5	64907456	64907456	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accctggtgttttccatattCtttgcagacacagcacatga	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:64907456C>A	ENST00000231524.9	-	4	990	c.619G>T	c.(619-621)Gaa>Taa	p.E207*	TRIM23_ENST00000274327.7_Nonsense_Mutation_p.E207*|TRIM23_ENST00000381018.3_Nonsense_Mutation_p.E207*	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	207					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		TTTCCATATTCTTTGCAGACA	0.418													24	47					3.08376e-08	3.62155e-08	1	1	0	A	64907456	C	A	64907456	4	1	48	1	0	0	0	0	0	1	0	0	16557	922	32	2	1204	2	TRIM23	5	64907456	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93043	64907456	116007804	1420	5814										
SGTB	54557	broad.mit.edu	37	chr5	65016598	65016598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actttgttcccgtaagaaacGaataactgcataaaccaggt	7	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:65016598G>A	ENST00000381007.4	-	2	272	c.37C>T	c.(37-39)Cgt>Tgt	p.R13C		NM_019072.2	NP_061945.1	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	13							binding			large_intestine(3)|lung(3)|skin(3)	9		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		CGTAAGAAACGAATAACTGCA	0.328													11	23					0	0	1	0	0	A	65016598	G	A	65016598	3	1	48	1	0	0	0	0	1	0	0	0	14279	1058	37	1	917	1	SGTB	5	65016598	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	109142	65016598	115898662	1421	5815										
MAST4	375449	broad.mit.edu	37	chr5	66448468	66448468	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcttctttgttacagataTgtttgctgtttcccctctgg	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:66448468T>C	ENST00000404260.3	+	25	3616	c.3308T>C	c.(3307-3309)aTg>aCg	p.M1103T	MAST4_ENST00000405643.1_Missense_Mutation_p.M921T|MAST4_ENST00000403666.1_Missense_Mutation_p.M911T|MAST4_ENST00000261569.7_Missense_Mutation_p.M906T|MAST4_ENST00000403625.2_Missense_Mutation_p.M1100T			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1103	Ser-rich.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GTTACAGATATGTTTGCTGTT	0.542													41	66					0	0	1	0	0	C	66448468	T	C	66448468	3	2	48	1	0	0	0	0	1	0	0	0	9376	1464	51	4	3527	4	MAST4	5	66448468	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1431870	66448468	114466792	1422	5816										
CD180	4064	broad.mit.edu	37	chr5	66479942	66479942	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagactgagtagtagagttCtgcagaccattgaatataac	10	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:66479942C>T	ENST00000256447.4	-	3	886	c.729G>A	c.(727-729)caG>caA	p.Q243Q		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	243					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TAGTAGAGTTCTGCAGACCAT	0.408													25	43					0	0	1	0	0	T	66479942	C	T	66479942	2	4	48	1	0	0	0	0	0	0	0	1	2994	912	32	3		3	CD180	5	66479942	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31474	66479942	114435318	1423	5817										
OCLN	100506658	broad.mit.edu	37	chr5	68805396	68805396	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgatctttgttaccagtgTtataagatctgaaatgtcca	9	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:68805396T>C	ENST00000355237.2	+	3	915	c.479T>C	c.(478-480)gTt>gCt	p.V160A	OCLN_ENST00000396442.2_Missense_Mutation_p.V160A|OCLN_ENST00000542132.1_Intron|OCLN_ENST00000538151.1_Intron|OCLN_ENST00000380766.2_Missense_Mutation_p.V160A	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	160	MARVEL.				cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GTTACCAGTGTTATAAGATCT	0.438													49	72					0	0	1	0	0	C	68805396	T	C	68805396	3	2	48	1	0	0	0	0	1	0	0	0	10867	1725	60	4	485	4	OCLN	5	68805396	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2325454	68805396	112109864	1424	5818										
CARTPT	9607	broad.mit.edu	37	chr5	71015769	71015769	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgttcccatctatgagaaGaagtatggccaagtccccat	9	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71015769G>T	ENST00000296777.4	+	2	353	c.222G>T	c.(220-222)aaG>aaT	p.K74N	CARTPT_ENST00000513096.1_3'UTR	NM_004291.3	NP_004282.1	Q16568	CART_HUMAN	CART prepropeptide	74					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				large_intestine(1)|lung(2)|ovary(1)	4		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	TCTATGAGAAGAAGTATGGCC	0.498													27	56					7.26314e-15	9.49782e-15	1	1	0	T	71015769	G	T	71015769	3	4	48	1	0	0	0	0	1	0	0	0	2677	933	33	2	228	2	CARTPT	5	71015769	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2210373	71015769	109899491	1425	5819										
MAP1B	4131	broad.mit.edu	37	chr5	71489773	71489773	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgaagaaggggactggaaGaactccaatcttgacagaca	11	9	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71489773G>T	ENST00000296755.7	+	5	889	c.591G>T	c.(589-591)aaG>aaT	p.K197N		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	197						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGGACTGGAAGAACTCCAATC	0.433													30	46					2.70662e-09	3.24368e-09	1	1	0	T	71489773	G	T	71489773	3	4	48	1	0	0	0	0	1	0	0	0	9277	933	33	2	609	2	MAP1B	5	71489773	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	474004	71489773	109425487	1426	5820										
MAP1B	4131	broad.mit.edu	37	chr5	71491766	71491766	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcctcagctggagctaatcGaagacgaagagaaactgaag	12	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71491766G>A	ENST00000296755.7	+	5	2882	c.2584G>A	c.(2584-2586)Gaa>Aaa	p.E862K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	862						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGAGCTAATCGAAGACGAAGA	0.493													9	196					0	0	1	0	0	A	71491766	G	A	71491766	3	1	48	1	0	0	0	0	1	0	0	0	9277	1059	37	1	2602	1	MAP1B	5	71491766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1993	71491766	109423494	1427	5821										
MAP1B	4131	broad.mit.edu	37	chr5	71491928	71491928	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaggagctggagcccgtcGagaagcagggagtagacgac	17	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71491928G>A	ENST00000296755.7	+	5	3044	c.2746G>A	c.(2746-2748)Gag>Aag	p.E916K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	916						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGAGCCCGTCGAGAAGCAGGG	0.502													7	134					0	0	1	0	0	A	71491928	G	A	71491928	3	1	48	1	0	0	0	0	1	0	0	0	9277	1059	37	1	2764	1	MAP1B	5	71491928	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	162	71491928	109423332	1428	5822										
MAP1B	4131	broad.mit.edu	37	chr5	71493698	71493698	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtttctcccacacaaataGatgtcagtcagtttggatct	7	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71493698G>T	ENST00000296755.7	+	5	4814	c.4516G>T	c.(4516-4518)Gat>Tat	p.D1506Y		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1506						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CACACAAATAGATGTCAGTCA	0.428													27	47					1.66031e-10	2.0393e-10	1	1	0	T	71493698	G	T	71493698	3	4	48	1	0	0	0	0	1	0	0	0	9277	942	33	2	4534	2	MAP1B	5	71493698	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1770	71493698	109421562	1429	5823										
MAP1B	4131	broad.mit.edu	37	chr5	71494405	71494405	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcataccccttctcagatCgcttctcctctccaagaaga	5	16	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71494405C>T	ENST00000296755.7	+	5	5521	c.5223C>T	c.(5221-5223)atC>atT	p.I1741I		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1741						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTTCTCAGATCGCTTCTCCTC	0.488													50	80					0	0	1	0	0	T	71494405	C	T	71494405	2	4	48	1	0	0	0	0	0	0	0	1	9277	874	31	1		1	MAP1B	5	71494405	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	707	71494405	109420855	1430	5824										
ZNF366	0	broad.mit.edu	37	chr5	71756207	71756207	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggccaaggtggggaagtCgaggccgcactccacacaga	15	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:71756207C>T	ENST00000318442.5	-	2	1607	c.1117G>A	c.(1117-1119)Gac>Aac	p.D373N		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GTGGGGAAGTCGAGGCCGCAC	0.657													20	35					0	0	1	0	0	T	71756207	C	T	71756207	3	4	48	1	0	0	0	0	1	0	0	0	17926	884	31	1	1133	1	ZNF366	5	71756207	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	261802	71756207	109159053	1431	5825										
TMEM174	134288	broad.mit.edu	37	chr5	72469090	72469090	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggagcagggcagcggccGcttggaggacttccctgtca	15	11	1	0	rs142247362		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:72469090G>A	ENST00000296776.5	+	1	69	c.20G>A	c.(19-21)cGc>cAc	p.R7H		NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	7						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		GGCAGCGGCCGCTTGGAGGAC	0.552													10	148					0	0	1	0	0	A	72469090	G	A	72469090	3	1	48	1	0	0	0	0	1	0	0	0	16149	1087	38	1	22	1	TMEM174	5	72469090	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	712883	72469090	108446170	1432	5826										
GCNT4	51301	broad.mit.edu	37	chr5	74325297	74325297	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacagcctctaatttggaaGcaatgaaaatattggagaag	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:74325297G>T	ENST00000322348.4	-	1	1427	c.566C>A	c.(565-567)gCt>gAt	p.A189D		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	189					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TAATTTGGAAGCAATGAAAAT	0.398													40	66					3.61848e-18	4.89221e-18	1	1	0	T	74325297	G	T	74325297	3	4	48	1	0	0	0	0	1	0	0	0	6342	971	34	5	799	5	GCNT4	5	74325297	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1856207	74325297	106589963	1433	5827										
HMGCR	3156	broad.mit.edu	37	chr5	74655286	74655286	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaagcaagtggtcccacaAatgaagatttatatatcagc	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:74655286A>C	ENST00000287936.4	+	18	2518	c.2362A>C	c.(2362-2364)Aat>Cat	p.N788H	HMGCR_ENST00000511206.1_Missense_Mutation_p.N788H|HMGCR_ENST00000343975.5_Missense_Mutation_p.N735H	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	788	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	TGGTCCCACAAATGAAGATTT	0.408													10	30					0	0	1	0	0	C	74655286	A	C	74655286	3	2	48	1	0	0	0	0	1	0	0	0	7271	14	1	4	2428	4	HMGCR	5	74655286	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	329989	74655286	106259974	1434	5828										
COL4A3BP	10087	broad.mit.edu	37	chr5	74698848	74698848	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagcttcaacagcatcaaaGaactcttcttcattaatcag	5	11	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:74698848G>T	ENST00000380494.5	-	10	1643	c.1350C>A	c.(1348-1350)ttC>ttA	p.F450L	COL4A3BP_ENST00000405807.4_Missense_Mutation_p.F322L|COL4A3BP_ENST00000261415.7_Missense_Mutation_p.F322L	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	322	START.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		CAGCATCAAAGAACTCTTCTT	0.318													13	28					0.00010058	0.000108553	1	1	0	T	74698848	G	T	74698848	3	4	48	1	0	0	0	0	1	0	0	0	3715	933	33	2	944	2	COL4A3BP	5	74698848	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	43562	74698848	106216412	1435	5829										
POLK	51426	broad.mit.edu	37	chr5	74892722	74892722	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctagtctcccaagcaagtCttttaatattgaacactgtc	5	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:74892722C>A	ENST00000241436.4	+	13	2376	c.2204C>A	c.(2203-2205)tCt>tAt	p.S735Y	POLK_ENST00000506928.1_3'UTR|POLK_ENST00000504026.1_Intron|POLK_ENST00000380481.3_Missense_Mutation_p.S645Y|POLK_ENST00000352007.5_Missense_Mutation_p.S537Y|POLK_ENST00000508526.1_Missense_Mutation_p.S537Y	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	735					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		CCAAGCAAGTCTTTTAATATT	0.348								DNA polymerases (catalytic subunits)					15	31					1.37285e-15	1.81125e-15	1	1	0	A	74892722	C	A	74892722	3	1	48	1	0	0	0	0	1	0	0	0	12251	913	32	2	2250	2	POLK	5	74892722	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	193874	74892722	106022538	1436	5830										
IQGAP2	10788	broad.mit.edu	37	chr5	75896636	75896636	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgccatatgttttccaacaGaactacttggcccacgagga	8	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:75896636G>T	ENST00000274364.6	+	11	1368		c.e11-1		IQGAP2_ENST00000379730.3_Splice_Site	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TTTTCCAACAGAACTACTTGG	0.433													12	45					3.07112e-06	3.42433e-06	1	1	0	T	75896636	G	T	75896636	5	4	48	1	0	0	0	0	0	0	1	0	7858	956	33	2	1113	2	IQGAP2	5	75896636	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1003914	75896636	105018624	1437	5831										
IQGAP2	10788	broad.mit.edu	37	chr5	75964567	75964567	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagaacaagtccactaaatTtatggatactgttattttca	5	7	1	1	rs146422169		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:75964567T>C	ENST00000274364.6	+	23	3038	c.2741T>C	c.(2740-2742)tTt>tCt	p.F914S	IQGAP2_ENST00000379730.3_Missense_Mutation_p.F416S|IQGAP2_ENST00000396234.3_Missense_Mutation_p.F410S|IQGAP2_ENST00000502745.1_Missense_Mutation_p.F410S	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	914					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TCCACTAAATTTATGGATACT	0.343													5	25					0	0	1	0	0	C	75964567	T	C	75964567	3	2	48	1	0	0	0	0	1	0	0	0	7858	1841	64	4	2831	4	IQGAP2	5	75964567	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	67931	75964567	104950693	1438	5832										
F2RL1	2150	broad.mit.edu	37	chr5	76115015	76115015	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttccaggaggatgcggaGccccagcgcggcgtggctgc	18	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:76115015G>A	ENST00000296677.4	+	1	214	c.8G>A	c.(7-9)aGc>aAc	p.S3N		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	3					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		AGGATGCGGAGCCCCAGCGCG	0.682													3	13					0	0	1	0	0	A	76115015	G	A	76115015	3	1	48	1	0	0	0	0	1	0	0	0	5372	971	34	3	10	3	F2RL1	5	76115015	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	150448	76115015	104800245	1439	5833										
AGGF1	55109	broad.mit.edu	37	chr5	76344055	76344055	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctgtgttgcagataggatCactctttatcattactgctg	8	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:76344055C>A	ENST00000312916.7	+	7	1653	c.1271C>A	c.(1270-1272)tCa>tAa	p.S424*		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	424					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		CAGATAGGATCACTCTTTATC	0.323													7	84					8.12818e-05	8.79784e-05	1	1	0	A	76344055	C	A	76344055	4	1	48	1	0	0	0	0	0	1	0	0	379	838	29	2	1297	2	AGGF1	5	76344055	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	229040	76344055	104571205	1440	5834										
PDE8B	8622	broad.mit.edu	37	chr5	76645304	76645304	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggtgagctcctgggaaaaGaactcgctgatctgcccaaa	11	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:76645304G>T	ENST00000264917.5	+	8	982	c.937G>T	c.(937-939)Gaa>Taa	p.E313*	PDE8B_ENST00000342343.4_Nonsense_Mutation_p.E293*|PDE8B_ENST00000333194.4_Nonsense_Mutation_p.E313*|PDE8B_ENST00000340978.3_Intron|PDE8B_ENST00000346042.3_Intron	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	313	PAS.				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CCTGGGAAAAGAACTCGCTGA	0.502													30	64					8.58068e-18	1.15595e-17	1	1	0	T	76645304	G	T	76645304	4	4	48	1	0	0	0	0	0	1	0	0	11700	943	33	2	967	2	PDE8B	5	76645304	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	301249	76645304	104269956	1441	5835										
WDR41	55255	broad.mit.edu	37	chr5	76729109	76729109	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatcttcaaagtatagaaAcatctgtaaagaaaattaaa	5	4	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:76729109A>G	ENST00000296679.4	-	13	1606	c.1231T>C	c.(1231-1233)Ttt>Ctt	p.F411L	WDR41_ENST00000414719.2_Missense_Mutation_p.F157L|WDR41_ENST00000507029.1_Missense_Mutation_p.F356L|WDR41_ENST00000512033.1_5'UTR	NM_018268.2	NP_060738.2	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	411										NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)	14		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		AAGTATAGAAACATCTGTAAA	0.388													4	22					0	0	1	0	0	G	76729109	A	G	76729109	3	3	48	1	0	0	0	0	1	0	0	0	17353	43	2	4	152	4	WDR41	5	76729109	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	83805	76729109	104186151	1442	5836										
ARSB	411	broad.mit.edu	37	chr5	78076220	78076220	+	Nonstop_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctagcctccctgaaatcCtacatccaagggccccacac	5	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:78076220C>A	ENST00000264914.4	-	8	2138	c.1602G>T	c.(1600-1602)taG>taT	p.*534Y		NM_000046.3	NP_000037.2	P15848	ARSB_HUMAN	arylsulfatase B	0					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		CCCTGAAATCCTACATCCAAG	0.527													8	78					1.06961e-07	1.24214e-07	1	1	0	A	78076220	C	A	78076220	4	1	48	1	0	0	0	0	0	0	0	0	987	692	24	5	3	5	ARSB	5	78076220	Nonstop_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1347111	78076220	102839040	1443	5837										
DMGDH	29958	broad.mit.edu	37	chr5	78350097	78350097	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccagccagtccgagtcatTtgatatttaaattcatctac	6	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:78350097T>C	ENST00000255189.3	-	4	478	c.450A>G	c.(448-450)caA>caG	p.Q150Q	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	150					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TCCGAGTCATTTGATATTTAA	0.408													15	41					0	0	1	0	0	C	78350097	T	C	78350097	2	2	48	1	0	0	0	0	0	0	0	1	4609	1838	64	4		4	DMGDH	5	78350097	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	273877	78350097	102565163	1444	5838										
BHMT	635	broad.mit.edu	37	chr5	78417160	78417160	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcatggcgtgccccccggCgagtgtgcagtgcgcctggt	16	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:78417160C>T	ENST00000274353.5	+	5	704	c.597C>T	c.(595-597)ggC>ggT	p.G199G	DMGDH_ENST00000520388.1_5'UTR|BHMT_ENST00000524080.1_Intron	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	199	Hcy-binding.		G -> S (in dbSNP:rs59866108).		protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	TGCCCCCCGGCGAGTGTGCAG	0.488													14	76					0	0	1	0	0	T	78417160	C	T	78417160	2	4	48	1	0	0	0	0	0	0	0	1	1424	755	27	1		1	BHMT	5	78417160	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67063	78417160	102498100	1445	5839										
HOMER1	9456	broad.mit.edu	37	chr5	78734966	78734966	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agactgaagatccccgcctgCggattcctttaaaaaaaggg	10	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:78734966C>T	ENST00000334082.6	-	5	1836	c.394G>A	c.(394-396)Gca>Aca	p.A132T	HOMER1_ENST00000535690.1_Intron|HOMER1_ENST00000508576.1_Missense_Mutation_p.A132T|HOMER1_ENST00000282260.6_Intron	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	132					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		TCCCCGCCTGCGGATTCCTTT	0.418													7	50					0	0	1	0	0	T	78734966	C	T	78734966	3	4	48	1	0	0	0	0	1	0	0	0	7318	768	27	1	690	1	HOMER1	5	78734966	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	317806	78734966	102180294	1446	5840										
CMYA5	202333	broad.mit.edu	37	chr5	79028508	79028508	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggagatgaaacatgattCcaaaataacaactacaccta	5	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:79028508C>A	ENST00000446378.2	+	2	3951	c.3920C>A	c.(3919-3921)tCc>tAc	p.S1307Y		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1307						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAACATGATTCCAAAATAACA	0.393													9	18					0.000673444	0.000709932	1	1	0	A	79028508	C	A	79028508	3	1	48	1	0	0	0	0	1	0	0	0	3613	855	30	2	3926	2	CMYA5	5	79028508	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	293542	79028508	101886752	1447	5841										
CMYA5	202333	broad.mit.edu	37	chr5	79028699	79028699	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttaaccagagcagtaaaaGaagaaatcccaacagattca	6	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:79028699G>T	ENST00000446378.2	+	2	4142	c.4111G>T	c.(4111-4113)Gaa>Taa	p.E1371*		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1371						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGCAGTAAAAGAAGAAATCCC	0.383													15	16					3.27435e-08	3.83577e-08	1	1	0	T	79028699	G	T	79028699	4	4	48	1	0	0	0	0	0	1	0	0	3613	943	33	2	4117	2	CMYA5	5	79028699	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	191	79028699	101886561	1448	5842										
CMYA5	202333	broad.mit.edu	37	chr5	79084796	79084796	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttcctcttgtatttagatCtttctctggaatcaaaggac	6	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:79084796C>A	ENST00000446378.2	+	10	11589	c.11558C>A	c.(11557-11559)tCt>tAt	p.S3853Y	CTC-431G16.2_ENST00000421252.2_RNA	NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3853	Fibronectin type-III 2.					perinuclear region of cytoplasm		p.S3853Y(1)		NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GTATTTAGATCTTTCTCTGGA	0.338													24	39					3.5997e-14	4.67138e-14	1	1	0	A	79084796	C	A	79084796	3	1	48	1	0	0	0	0	1	0	0	0	3613	913	32	2	11596	2	CMYA5	5	79084796	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	56097	79084796	101830464	1449	5843										
ZFYVE16	9765	broad.mit.edu	37	chr5	79734320	79734320	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgataaacaaaatacaataGaaaatggcctttctttagga	6	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:79734320G>T	ENST00000338008.5	+	3	1996	c.1816G>T	c.(1816-1818)Gaa>Taa	p.E606*	ZFYVE16_ENST00000505560.1_Nonsense_Mutation_p.E606*|ZFYVE16_ENST00000510158.1_Nonsense_Mutation_p.E606*	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	606					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AAATACAATAGAAAATGGCCT	0.313													37	68					4.65686e-17	6.22576e-17	1	1	0	T	79734320	G	T	79734320	4	4	48	1	0	0	0	0	0	1	0	0	17721	943	33	2	1822	2	ZFYVE16	5	79734320	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	649524	79734320	101180940	1450	5844										
ZCCHC9	84240	broad.mit.edu	37	chr5	80600780	80600780	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaagaaaaaagagtacttAaatgaagatgtgaatggatt	9	1	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:80600780A>C	ENST00000254037.2	+	1	3359	c.204A>C	c.(202-204)ttA>ttC	p.L68F	ZCCHC9_ENST00000380199.5_Missense_Mutation_p.L68F|ZCCHC9_ENST00000438268.2_Missense_Mutation_p.L68F|ZCCHC9_ENST00000506458.1_Intron|ZCCHC9_ENST00000407610.3_Missense_Mutation_p.L68F			Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	68							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)	13		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		AAGAGTACTTAAATGAAGATG	0.373													24	40					0	0	1	0	0	C	80600780	A	C	80600780	3	2	48	1	0	0	0	0	1	0	0	0	17652	359	13	4	206	4	ZCCHC9	5	80600780	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	866460	80600780	100314480	1451	5845										
VCAN	1462	broad.mit.edu	37	chr5	82816211	82816211	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactaataccagagatgagaAcagatacttatacagatgaa	7	7	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:82816211A>G	ENST00000265077.3	+	7	2651	c.2086A>G	c.(2086-2088)Aca>Gca	p.T696A	VCAN_ENST00000512590.2_Missense_Mutation_p.T648A|VCAN_ENST00000342785.4_Missense_Mutation_p.T696A|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	696	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGAGATGAGAACAGATACTTA	0.338													13	25					0	0	1	0	0	G	82816211	A	G	82816211	3	3	48	1	0	0	0	0	1	0	0	0	17197	43	2	4	2108	4	VCAN	5	82816211	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2215431	82816211	98099049	1452	5846										
VCAN	1462	broad.mit.edu	37	chr5	82833745	82833745	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgattccaattacagaaggCtctggagaagcagaagaaga	11	7	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:82833745C>T	ENST00000265077.3	+	8	5488	c.4923C>T	c.(4921-4923)ggC>ggT	p.G1641G	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Silent_p.G654G	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1641	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTACAGAAGGCTCTGGAGAAG	0.418													16	38					0	0	1	0	0	T	82833745	C	T	82833745	2	4	48	1	0	0	0	0	0	0	0	1	17197	784	28	3		3	VCAN	5	82833745	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17534	82833745	98081515	1453	5847										
VCAN	1462	broad.mit.edu	37	chr5	82837802	82837802	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggcaggtgtggtgccttggCtaagtccacagacttctgag	14	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:82837802C>A	ENST00000265077.3	+	8	9545	c.8980C>A	c.(8980-8982)Cta>Ata	p.L2994I	VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Missense_Mutation_p.L2007I	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2994	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGTGCCTTGGCTAAGTCCACA	0.498													41	61					2.40579e-17	3.22781e-17	1	1	0	A	82837802	C	A	82837802	3	1	48	1	0	0	0	0	1	0	0	0	17197	796	28	5	9006	5	VCAN	5	82837802	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4057	82837802	98077458	1454	5848										
MEF2C	4208	broad.mit.edu	37	chr5	88018554	88018554	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcggtcgctcccgtcgtacGaactgctacagctgctcaag	10	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:88018554G>A	ENST00000504921.2	-	10	1961	c.1289C>T	c.(1288-1290)tCg>tTg	p.S430L	MEF2C_ENST00000340208.5_Missense_Mutation_p.S440L|MEF2C_ENST00000514028.1_Missense_Mutation_p.S430L|MEF2C_ENST00000508569.1_Missense_Mutation_p.S390L|CTC-467M3.1_ENST00000510274.1_RNA|MEF2C_ENST00000510942.1_Missense_Mutation_p.S422L|MEF2C_ENST00000539796.1_Missense_Mutation_p.S374L|MEF2C_ENST00000424173.2_Missense_Mutation_p.S420L|MEF2C_ENST00000514015.1_Missense_Mutation_p.S398L|MEF2C_ENST00000437473.2_Missense_Mutation_p.S430L|MEF2C_ENST00000506554.1_3'UTR			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	430					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CCCGTCGTACGAACTGCTACA	0.592										HNSCC(66;0.2)			18	114					0	0	1	0	0	A	88018554	G	A	88018554	3	1	48	1	0	0	0	0	1	0	0	0	9506	1059	37	1	136	1	MEF2C	5	88018554	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5180752	88018554	92896706	1455	5849										
LYSMD3	116068	broad.mit.edu	37	chr5	89814938	89814938	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctgctccataataggggtCtttacgttgagtgtttttgt	11	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:89814938C>A	ENST00000315948.6	-	3	763	c.619G>T	c.(619-621)Gac>Tac	p.D207Y	LYSMD3_ENST00000500869.2_Intron|LYSMD3_ENST00000509384.1_3'UTR	NM_198273.1	NP_938014.1	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain containing 3	207					cell wall macromolecule catabolic process	integral to membrane				breast(2)|large_intestine(1)|lung(2)|prostate(1)|urinary_tract(1)	7		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		TAATAGGGGTCTTTACGTTGA	0.393													10	97					6.40141e-05	6.95424e-05	1	1	0	A	89814938	C	A	89814938	3	1	48	1	0	0	0	0	1	0	0	0	9171	913	32	2	305	2	LYSMD3	5	89814938	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1796384	89814938	91100322	1456	5850										
GPR98	84059	broad.mit.edu	37	chr5	89938771	89938771	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaagagatagcaatgaattCtatggaaacacgggagtact	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:89938771C>A	ENST00000405460.2	+	13	2562	c.2466C>A	c.(2464-2466)ttC>ttA	p.F822L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	822	Calx-beta 6.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCAATGAATTCTATGGAAACA	0.443													49	85					4.18559e-23	5.84444e-23	1	1	0	A	89938771	C	A	89938771	3	1	48	1	0	0	0	0	1	0	0	0	6761	912	32	2	2516	2	GPR98	5	89938771	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	123833	89938771	90976489	1457	5851										
GPR98	84059	broad.mit.edu	37	chr5	89948330	89948330	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccatgcttttccagataAaattcctgaattcaatgaat	4	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:89948330A>C	ENST00000405460.2	+	19	3680	c.3584A>C	c.(3583-3585)aAa>aCa	p.K1195T		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1195	Calx-beta 9.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTCCAGATAAAATTCCTGAA	0.338													16	19					0	0	1	0	0	C	89948330	A	C	89948330	3	2	48	1	0	0	0	0	1	0	0	0	6761	14	1	4	3658	4	GPR98	5	89948330	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	9559	89948330	90966930	1458	5852										
GPR98	84059	broad.mit.edu	37	chr5	89949626	89949626	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatgctacatacattgccaAgacaacagtcatgaaatatt	5	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:89949626A>G	ENST00000405460.2	+	20	4331	c.4235A>G	c.(4234-4236)aAg>aGg	p.K1412R		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1412					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TACATTGCCAAGACAACAGTC	0.378													3	16					0	0	1	0	0	G	89949626	A	G	89949626	3	3	48	1	0	0	0	0	1	0	0	0	6761	72	3	4	4313	4	GPR98	5	89949626	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1296	89949626	90965634	1459	5853										
GPR98	84059	broad.mit.edu	37	chr5	90077323	90077323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggaaacatctccattgttCgcatcataataatgaaaaat	5	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:90077323C>T	ENST00000405460.2	+	65	13255	c.13159C>T	c.(13159-13161)Cgc>Tgc	p.R4387C	GPR98_ENST00000425867.2_Missense_Mutation_p.R48C	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4387					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCCATTGTTCGCATCATAAT	0.363													8	11					0	0	1	0	0	T	90077323	C	T	90077323	3	4	48	1	0	0	0	0	1	0	0	0	6761	884	31	1	13417	1	GPR98	5	90077323	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	127697	90077323	90837937	1460	5854										
GPR98	84059	broad.mit.edu	37	chr5	90087050	90087050	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagatgtggctgttgggcttCgaatatcatcggatcataaa	12	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:90087050C>T	ENST00000405460.2	+	70	14500	c.14404C>T	c.(14404-14406)Cga>Tga	p.R4802*	GPR98_ENST00000425867.2_Nonsense_Mutation_p.R463*	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4802					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.R4802*(1)		NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTTGGGCTTCGAATATCATC	0.463													3	20					0	0	1	0	0	T	90087050	C	T	90087050	4	4	48	1	0	0	0	0	0	1	0	0	6761	876	31	1	14682	1	GPR98	5	90087050	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9727	90087050	90828210	1461	5855										
GPR98	84059	broad.mit.edu	37	chr5	90151704	90151704	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccttcttcacttctggatTtatatgtatctcaggtcagt	7	9	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:90151704T>G	ENST00000405460.2	+	82	17837	c.17741T>G	c.(17740-17742)tTt>tGt	p.F5914C	GPR98_ENST00000425867.2_Missense_Mutation_p.F1575C	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5914					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTTCTGGATTTATATGTATC	0.363													16	41					0	0	1	0	0	G	90151704	T	G	90151704	3	3	48	1	0	0	0	0	1	0	0	0	6761	1841	64	4	18067	4	GPR98	5	90151704	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	64654	90151704	90763556	1462	5856										
SPATA9	83890	broad.mit.edu	37	chr5	95018287	95018287	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcatctttaaactcatctAcaaggtccatgattgctttc	4	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:95018287A>G	ENST00000274432.8	-	2	236	c.95T>C	c.(94-96)gTa>gCa	p.V32A	RFESD_ENST00000508206.1_Intron|SPATA9_ENST00000395899.3_Missense_Mutation_p.V32A|SPATA9_ENST00000477047.2_5'UTR	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	32					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		AAACTCATCTACAAGGTCCAT	0.318													13	26					0	0	1	0	0	G	95018287	A	G	95018287	3	3	48	1	0	0	0	0	1	0	0	0	15071	391	14	4	685	4	SPATA9	5	95018287	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4866583	95018287	85896973	1463	5857										
ELL2	22936	broad.mit.edu	37	chr5	95242363	95242363	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtccctgtatggcctctgaGagatggtgctgctgctatgt	13	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:95242363G>T	ENST00000237853.4	-	5	954	c.605C>A	c.(604-606)tCt>tAt	p.S202Y	ELL2_ENST00000506628.1_5'UTR|ELL2_ENST00000431061.2_Intron	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	202					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TGGCCTCTGAGAGATGGTGCT	0.488													17	100					1.15088e-07	1.32965e-07	1	1	0	T	95242363	G	T	95242363	3	4	48	1	0	0	0	0	1	0	0	0	5091	942	33	2	1349	2	ELL2	5	95242363	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	224076	95242363	85672897	1464	5858										
PCSK1	5122	broad.mit.edu	37	chr5	95751803	95751803	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttgcttgcatggcaatttCtcctgcacatctggtcccgt	8	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:95751803C>A	ENST00000311106.3	-	6	880	c.643G>T	c.(643-645)Gaa>Taa	p.E215*	PCSK1_ENST00000508626.1_Nonsense_Mutation_p.E168*|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	215	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGGCAATTTCTCCTGCACAT	0.383													18	31					6.33239e-15	8.29613e-15	1	1	0	A	95751803	C	A	95751803	4	1	48	1	0	0	0	0	0	1	0	0	11646	922	32	2	1654	2	PCSK1	5	95751803	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	509440	95751803	85163457	1465	5859										
CAST	831	broad.mit.edu	37	chr5	96071887	96071887	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcaccagaaaaaagaaaaGaaatcattaaccccagctgt	5	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:96071887G>T	ENST00000395813.1	+	10	828	c.642G>T	c.(640-642)aaG>aaT	p.K214N	CAST_ENST00000395812.2_Missense_Mutation_p.K173N|CAST_ENST00000511049.1_Missense_Mutation_p.K117N|CAST_ENST00000509903.1_Missense_Mutation_p.K109N|CAST_ENST00000510756.1_Missense_Mutation_p.K192N|CAST_ENST00000325674.7_Missense_Mutation_p.K192N|CAST_ENST00000309190.5_Missense_Mutation_p.K109N|CAST_ENST00000359176.4_Missense_Mutation_p.K195N|CAST_ENST00000508830.1_Missense_Mutation_p.K214N|CAST_ENST00000508608.1_Missense_Mutation_p.K177N|CAST_ENST00000504465.1_Intron|CAST_ENST00000511782.1_Missense_Mutation_p.K117N|CAST_ENST00000348386.3_3'UTR|CAST_ENST00000341926.3_Missense_Mutation_p.K131N|CAST_ENST00000338252.3_Missense_Mutation_p.K131N			P20810	ICAL_HUMAN	calpastatin	131							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		AAAAAGAAAAGAAATCATTAA	0.318													7	17					0.000157383	0.000169016	1	1	0	T	96071887	G	T	96071887	3	4	48	1	0	0	0	0	1	0	0	0	2702	933	33	2	680	2	CAST	5	96071887	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	320084	96071887	84843373	1466	5860										
CAST	831	broad.mit.edu	37	chr5	96106290	96106290	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctaagaatggaggtaaagCgaaggattcagcaaaggtaa	12	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:96106290C>T	ENST00000395813.1	+	30	2510	c.2324C>T	c.(2323-2325)gCg>gTg	p.A775V	CAST_ENST00000510756.1_Missense_Mutation_p.A753V|ERAP1_ENST00000296754.3_Intron|CAST_ENST00000395812.2_Missense_Mutation_p.A734V|CAST_ENST00000511049.1_Missense_Mutation_p.A677V|CAST_ENST00000509903.1_Missense_Mutation_p.A657V|CAST_ENST00000508579.1_Missense_Mutation_p.A407V|CAST_ENST00000515663.1_Missense_Mutation_p.A415V|CAST_ENST00000325674.7_Missense_Mutation_p.A740V|CAST_ENST00000309190.5_Missense_Mutation_p.A670V|CAST_ENST00000359176.4_Missense_Mutation_p.A756V|CAST_ENST00000508830.1_Missense_Mutation_p.A775V|CAST_ENST00000508608.1_Missense_Mutation_p.A738V|CAST_ENST00000504465.1_Missense_Mutation_p.A620V|CAST_ENST00000511782.1_Missense_Mutation_p.A678V|CAST_ENST00000348386.3_3'UTR|CAST_ENST00000341926.3_Missense_Mutation_p.A692V|CAST_ENST00000338252.3_Missense_Mutation_p.A679V			P20810	ICAL_HUMAN	calpastatin	692							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		GGAGGTAAAGCGAAGGATTCA	0.393													6	35					0	0	1	0	0	T	96106290	C	T	96106290	3	4	48	1	0	0	0	0	1	0	0	0	2702	768	27	1	2566	1	CAST	5	96106290	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34403	96106290	84808970	1467	5861										
ERAP2	64167	broad.mit.edu	37	chr5	96219620	96219620	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagcaggcatattgcactaTccaacatgccaaaggtatgt	9	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:96219620T>C	ENST00000437043.3	+	3	1411	c.700T>C	c.(700-702)Tcc>Ccc	p.S234P	ERAP2_ENST00000379904.4_Missense_Mutation_p.S234P|ERAP2_ENST00000510309.1_Missense_Mutation_p.S234P|CTD-2260A17.2_ENST00000501338.1_Intron	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	234					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TATTGCACTATCCAACATGCC	0.408													16	21					0	0	1	0	0	C	96219620	T	C	96219620	3	2	48	1	0	0	0	0	1	0	0	0	5232	1435	50	4	706	4	ERAP2	5	96219620	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	113330	96219620	84695640	1468	5862										
ERAP2	64167	broad.mit.edu	37	chr5	96235878	96235878	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttgtcattcggatcccaaGatgacaagtaacatggtaag	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:96235878G>T	ENST00000437043.3	+	10	2268	c.1557G>T	c.(1555-1557)aaG>aaT	p.K519N	ERAP2_ENST00000379904.4_Missense_Mutation_p.K474N|ERAP2_ENST00000515095.1_3'UTR|CTD-2260A17.2_ENST00000501338.1_Intron	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	519					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		CGGATCCCAAGATGACAAGTA	0.403													27	62					2.36697e-06	2.64971e-06	1	1	0	T	96235878	G	T	96235878	3	4	48	1	0	0	0	0	1	0	0	0	5232	933	33	2	1591	2	ERAP2	5	96235878	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16258	96235878	84679382	1469	5863										
CHD1	1105	broad.mit.edu	37	chr5	98236676	98236676	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattaacagttgcttggcgaCgagaacttcttttatcatta	7	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:98236676C>T	ENST00000284049.3	-	6	847	c.698G>A	c.(697-699)cGt>cAt	p.R233H		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	233					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TGCTTGGCGACGAGAACTTCT	0.368													21	42					0	0	1	0	0	T	98236676	C	T	98236676	3	4	48	1	0	0	0	0	1	0	0	0	3345	536	19	1	4554	1	CHD1	5	98236676	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2000798	98236676	82678584	1470	5864										
FAM174A	345757	broad.mit.edu	37	chr5	99871609	99871609	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccatgacccagcgggccctGaccgtgttgatggtggtgag	15	12	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:99871609G>A	ENST00000312637.4	+	1	601	c.375G>A	c.(373-375)ctG>ctA	p.L125L		NM_198507.1	NP_940909.1	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	125						integral to membrane				breast(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						AGCGGGCCCTGACCGTGTTGA	0.682													17	38					0	0	1	0	0	A	99871609	G	A	99871609	2	1	48	1	0	0	0	0	0	0	0	1	5524	1277	45	3		3	FAM174A	5	99871609	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1634933	99871609	81043651	1471	5865										
ST8SIA4	7903	broad.mit.edu	37	chr5	100191882	100191882	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattcttaaggattaatgcaTtaacccactccacgtgcttc	5	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:100191882T>C	ENST00000231461.5	-	4	1032	c.722A>G	c.(721-723)aAt>aGt	p.N241S		NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	241					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GATTAATGCATTAACCCACTC	0.423													29	43					0	0	1	0	0	C	100191882	T	C	100191882	3	2	48	1	0	0	0	0	1	0	0	0	15289	1493	52	4	365	4	ST8SIA4	5	100191882	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	320273	100191882	80723378	1472	5866										
SLCO4C1	353189	broad.mit.edu	37	chr5	101576442	101576442	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaataatcgaaggaccataAattgtattcccaaggctagg	8	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:101576442A>C	ENST00000310954.6	-	11	2142	c.1856T>G	c.(1855-1857)tTt>tGt	p.F619C		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	619					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		AAGGACCATAAATTGTATTCC	0.318													35	70					0	0	1	0	0	C	101576442	A	C	101576442	3	2	48	1	0	0	0	0	1	0	0	0	14784	14	1	4	330	4	SLCO4C1	5	101576442	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1384560	101576442	79338818	1473	5867										
SLCO4C1	353189	broad.mit.edu	37	chr5	101583039	101583039	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcaaaggaatatgggcagTttcgcacaatgagtttcaca	10	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:101583039T>C	ENST00000310954.6	-	10	2014	c.1728A>G	c.(1726-1728)aaA>aaG	p.K576K		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	576					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		ATATGGGCAGTTTCGCACAAT	0.363													30	58					0	0	1	0	0	C	101583039	T	C	101583039	2	2	48	1	0	0	0	0	0	0	0	1	14784	1722	60	4		4	SLCO4C1	5	101583039	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	6597	101583039	79332221	1474	5868										
SLCO4C1	353189	broad.mit.edu	37	chr5	101593765	101593765	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagttgatagaactaaacaCataaagacagcattcttcat	6	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:101593765C>T	ENST00000310954.6	-	7	1441	c.1155G>A	c.(1153-1155)atG>atA	p.M385I		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	385					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GAACTAAACACATAAAGACAG	0.303													10	28					0	0	1	0	0	T	101593765	C	T	101593765	3	4	48	1	0	0	0	0	1	0	0	0	14784	478	17	3	1047	3	SLCO4C1	5	101593765	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10726	101593765	79321495	1475	5869										
GIN1	54826	broad.mit.edu	37	chr5	102442537	102442537	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatggcattctcttaagacTttctttttttcctcttctga	4	10	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:102442537T>G	ENST00000399004.2	-	3	310	c.216A>C	c.(214-216)aaA>aaC	p.K72N	GIN1_ENST00000508629.1_Missense_Mutation_p.K72N	NM_017676.2	NP_060146.2	Q9NXP7	GIN1_HUMAN	gypsy retrotransposon integrase 1	72					DNA integration		DNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		CTCTTAAGACTTTCTTTTTTT	0.348													5	15					0	0	1	0	0	G	102442537	T	G	102442537	3	3	48	1	0	0	0	0	1	0	0	0	6427	1606	56	4	1376	4	GIN1	5	102442537	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	848772	102442537	78472723	1476	5870										
PPIP5K2	23262	broad.mit.edu	37	chr5	102519017	102519017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgtgggtactgggcgtcGaagacgcagatcaggggaac	18	7	1	2	rs144678063		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:102519017G>A	ENST00000321521.9	+	25	3578	c.3005G>A	c.(3004-3006)cGa>cAa	p.R1002Q	PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.R1002Q|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.R1002Q			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	1002					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						ACTGGGCGTCGAAGACGCAGA	0.512													18	31					0	0	1	0	0	A	102519017	G	A	102519017	3	1	48	1	0	0	0	0	1	0	0	0	12381	1058	37	1	3099	1	PPIP5K2	5	102519017	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	76480	102519017	78396243	1477	5871										
PPIP5K2	23262	broad.mit.edu	37	chr5	102537329	102537329	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaaaaacactgggaaaaaGaaatgaaatcttagcagaag	8	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:102537329G>T	ENST00000321521.9	+	30	4236	c.3663G>T	c.(3661-3663)aaG>aaT	p.K1221N	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.K1242N|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.K1221N			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	1242					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CTGGGAAAAAGAAATGAAATC	0.313													13	19					0.0931896	0.0943983	1	1	0	T	102537329	G	T	102537329	3	4	48	1	0	0	0	0	1	0	0	0	12381	933	33	2	3777	2	PPIP5K2	5	102537329	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	18312	102537329	78377931	1478	5872										
EFNA5	1946	broad.mit.edu	37	chr5	106763211	106763211	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtagtcacccctctggaatCtgttagaaaaagaaaaaaaa	8	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:106763211C>A	ENST00000333274.6	-	2	407		c.e2-1		EFNA5_ENST00000509503.1_Splice_Site	NM_001962.2	NP_001953.1	P52803	EFNA5_HUMAN	ephrin-A5						cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding			large_intestine(6)	6		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		CCTCTGGAATCTGTTAGAAAA	0.393													30	51					7.01153e-11	8.66693e-11	1	1	0	A	106763211	C	A	106763211	5	1	48	1	0	0	0	0	0	0	1	0	4980	927	32	2	577	2	EFNA5	5	106763211	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4225882	106763211	74152049	1479	5873										
FBXL17	64839	broad.mit.edu	37	chr5	107197556	107197556	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgttccaccgtcacttcGttgacctgcaaacaaagaag	8	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:107197556G>A	ENST00000542267.1	-	9	2377	c.1971C>T	c.(1969-1971)aaC>aaT	p.N657N	FBXL17_ENST00000359660.5_Silent_p.N259N	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	657										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		CCGTCACTTCGTTGACCTGCA	0.577													17	33					0	0	1	0	0	A	107197556	G	A	107197556	2	1	48	1	0	0	0	0	0	0	0	1	5745	1136	40	1		1	FBXL17	5	107197556	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	434345	107197556	73717704	1480	5874										
MAN2A1	4124	broad.mit.edu	37	chr5	109124646	109124646	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttacagactttttcattCgttaatggttttggagaaga	9	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:109124646C>T	ENST00000261483.4	+	11	2824	c.1772C>T	c.(1771-1773)tCg>tTg	p.S591L		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	591					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CTTTTTCATTCGTTAATGGTT	0.313													10	18					0	0	1	0	0	T	109124646	C	T	109124646	3	4	48	1	0	0	0	0	1	0	0	0	9263	893	31	1	1814	1	MAN2A1	5	109124646	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1927090	109124646	71790614	1481	5875										
MAN2A1	4124	broad.mit.edu	37	chr5	109202582	109202582	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttaaacaagtttattgtCgaaagtctcacaccttcatc	4	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:109202582C>T	ENST00000261483.4	+	22	4370	c.3318C>T	c.(3316-3318)gtC>gtT	p.V1106V		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	1106					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AGTTTATTGTCGAAAGTCTCA	0.348													27	30					0	0	1	0	0	T	109202582	C	T	109202582	2	4	48	1	0	0	0	0	0	0	0	1	9263	871	31	1		1	MAN2A1	5	109202582	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	77936	109202582	71712678	1482	5876										
APC	324	broad.mit.edu	37	chr5	112151216	112151216	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caactacacgaatggaccatGaaacagccagtgttttgagt	9	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112151216G>T	ENST00000457016.1	+	9	1239	c.859G>T	c.(859-861)Gaa>Taa	p.E287*	APC_ENST00000508376.2_Nonsense_Mutation_p.E287*|APC_ENST00000257430.4_Nonsense_Mutation_p.E287*			P25054	APC_HUMAN	adenomatous polyposis coli	287	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AATGGACCATGAAACAGCCAG	0.398		12	"D, Mis, N, F, S"		"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"	"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			21	36					7.41877e-09	8.8016e-09	1	1	0	T	112151216	G	T	112151216	4	4	48	1	0	0	0	0	0	1	0	0	759	1291	45	2	889	2	APC	5	112151216	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2948634	112151216	68764044	1483	5877										
APC	324	broad.mit.edu	37	chr5	112175120	112175120	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttttcaagatgtagttcaTtatcatctttgtcatcagct	6	7	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112175120T>G	ENST00000457016.1	+	16	4209	c.3829T>G	c.(3829-3831)Tta>Gta	p.L1277V	APC_ENST00000508376.2_Missense_Mutation_p.L1277V|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.L1277V			P25054	APC_HUMAN	adenomatous polyposis coli	1277	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATGTAGTTCATTATCATCTTT	0.343		12	"D, Mis, N, F, S"		"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"	"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			14	28					0	0	1	0	0	G	112175120	T	G	112175120	3	3	48	1	0	0	0	0	1	0	0	0	759	1490	52	4	3887	4	APC	5	112175120	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23904	112175120	68740140	1484	5878										
APC	324	broad.mit.edu	37	chr5	112175861	112175861	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaagatgtggaattaagaAtaatgcctccagttcaggaa	10	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112175861A>G	ENST00000457016.1	+	16	4950	c.4570A>G	c.(4570-4572)Ata>Gta	p.I1524V	APC_ENST00000508376.2_Missense_Mutation_p.I1524V|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.I1524V			P25054	APC_HUMAN	adenomatous polyposis coli	1524	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GGAATTAAGAATAATGCCTCC	0.398		12	"D, Mis, N, F, S"		"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"	"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			21	36					0	0	1	0	0	G	112175861	A	G	112175861	3	3	48	1	0	0	0	0	1	0	0	0	759	101	4	4	4628	4	APC	5	112175861	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	741	112175861	68739399	1485	5879										
APC	324	broad.mit.edu	37	chr5	112177901	112177901	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttgattactggaaaagttCgatctaattcagaaatttca	7	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112177901C>T	ENST00000457016.1	+	16	6990	c.6610C>T	c.(6610-6612)Cga>Tga	p.R2204*	APC_ENST00000508376.2_Nonsense_Mutation_p.R2204*|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Nonsense_Mutation_p.R2204*			P25054	APC_HUMAN	adenomatous polyposis coli	2204	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGGAAAAGTTCGATCTAATTC	0.363		12	"D, Mis, N, F, S"		"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"	"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			22	48					0	0	1	0	0	T	112177901	C	T	112177901	4	4	48	1	0	0	0	0	0	1	0	0	759	876	31	1	6668	1	APC	5	112177901	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2040	112177901	68737359	1486	5880										
APC	324	broad.mit.edu	37	chr5	112178190	112178190	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggtcaagtaaagcaccttCtagatcaggatctagagatt	10	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112178190C>A	ENST00000457016.1	+	16	7279	c.6899C>A	c.(6898-6900)tCt>tAt	p.S2300Y	APC_ENST00000508376.2_Missense_Mutation_p.S2300Y|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.S2300Y			P25054	APC_HUMAN	adenomatous polyposis coli	2300	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAAGCACCTTCTAGATCAGGA	0.493		12	"D, Mis, N, F, S"		"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"	"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			20	47					5.35267e-07	6.09026e-07	1	1	0	A	112178190	C	A	112178190	3	1	48	1	0	0	0	0	1	0	0	0	759	913	32	2	6957	2	APC	5	112178190	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	289	112178190	68737070	1487	5881										
APC	324	broad.mit.edu	37	chr5	112179240	112179240	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatttatcaaatggcacctgCtgtttctaaaacagaggatg	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112179240C>T	ENST00000457016.1	+	16	8329	c.7949C>T	c.(7948-7950)gCt>gTt	p.A2650V	APC_ENST00000508376.2_Missense_Mutation_p.A2650V|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.A2650V			P25054	APC_HUMAN	adenomatous polyposis coli	2650	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATGGCACCTGCTGTTTCTAAA	0.418		12	"D, Mis, N, F, S"		"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"	"colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			37	49					0	0	1	0	0	T	112179240	C	T	112179240	3	4	48	1	0	0	0	0	1	0	0	0	759	797	28	3	8007	3	APC	5	112179240	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1050	112179240	68736020	1488	5882										
REEP5	7905	broad.mit.edu	37	chr5	112238187	112238187	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccactgggtatcatcttCtttgttgggactctctatag	9	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112238187C>A	ENST00000379638.4	-	3	589	c.241G>T	c.(241-243)Gaa>Taa	p.E81*	REEP5_ENST00000545426.1_Nonsense_Mutation_p.E81*|REEP5_ENST00000474542.2_5'UTR|REEP5_ENST00000513339.1_Nonsense_Mutation_p.E81*|REEP5_ENST00000504247.1_Intron	NM_005669.4	NP_005660.4	Q00765	REEP5_HUMAN	receptor accessory protein 5	81						integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		GTATCATCTTCTTTGTTGGGA	0.373													16	41					9.7654e-05	0.000105618	1	1	0	A	112238187	C	A	112238187	4	1	48	1	0	0	0	0	0	1	0	0	13259	922	32	2	340	2	REEP5	5	112238187	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	58947	112238187	68677073	1489	5883										
YTHDC2	64848	broad.mit.edu	37	chr5	112903438	112903438	+	Missense_Mutation	SNP	A	A	C													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatgaccagagcccatagaAtagctaatattagatgttgt							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112903438A>C	ENST00000161863.4	+	23	3349	c.3136A>C	c.(3136-3138)Ata>Cta	p.I1046L		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1046							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AGCCCATAGAATAGCTAATAT	0.418													13	31					0	0	1	0	0	C	112903438	A	C	112903438	3	2	48	1	0	0	0	0	1	0	0	0	17556	101	4	4	3226	4	YTHDC2	5	112903438	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	665251	112903438	68011822	1490	5884	20	2								
YTHDC2	64848	broad.mit.edu	37	chr5	112903439	112903439	+	Missense_Mutation	SNP	T	T	C													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgaccagagcccatagaaTagctaatattagatgttgtt							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:112903439T>C	ENST00000161863.4	+	23	3350	c.3137T>C	c.(3136-3138)aTa>aCa	p.I1046T		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1046							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		GCCCATAGAATAGCTAATATT	0.423													19	26					0	0	1	0	0	C	112903439	T	C	112903439	3	2	48	1	0	0	0	0	1	0	0	0	17556	1406	49	4	3227	4	YTHDC2	5	112903439	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1	112903439	68011821	1491	5885	20	2								
SEMA6A	57556	broad.mit.edu	37	chr5	115822462	115822462	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctgttataaggtgtagaAaacgttgccaggacaacatc	9	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:115822462A>C	ENST00000343348.6	-	10	1732	c.945T>G	c.(943-945)ttT>ttG	p.F315L	CTB-118N6.3_ENST00000508640.1_RNA|SEMA6A_ENST00000510263.1_Missense_Mutation_p.F315L|CTB-118N6.3_ENST00000510682.1_RNA|CTB-118N6.3_ENST00000514214.1_RNA|SEMA6A_ENST00000257414.8_Missense_Mutation_p.F315L	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	315	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		AAGGTGTAGAAAACGTTGCCA	0.438													28	62					0	0	1	0	0	C	115822462	A	C	115822462	3	2	48	1	0	0	0	0	1	0	0	0	14092	11	1	4	2187	4	SEMA6A	5	115822462	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2919023	115822462	65092798	1492	5886										
DMXL1	1657	broad.mit.edu	37	chr5	118484688	118484688	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagctgtgcacatacaaatCgtttagcagtagcttataag	8	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:118484688C>T	ENST00000311085.8	+	18	3246	c.3166C>T	c.(3166-3168)Cgt>Tgt	p.R1056C	DMXL1_ENST00000539542.1_Missense_Mutation_p.R1056C	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1056										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		ACATACAAATCGTTTAGCAGT	0.403													59	81					0	0	1	0	0	T	118484688	C	T	118484688	3	4	48	1	0	0	0	0	1	0	0	0	4622	884	31	1	3236	1	DMXL1	5	118484688	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2662226	118484688	62430572	1493	5887										
DMXL1	1657	broad.mit.edu	37	chr5	118556647	118556647	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttatagatcagaagatttCttggttatacatgctcgtga	8	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:118556647C>A	ENST00000311085.8	+	36	8165	c.8085C>A	c.(8083-8085)ttC>ttA	p.F2695L	DMXL1_ENST00000539542.1_Missense_Mutation_p.F2716L|DMXL1_ENST00000505312.1_3'UTR	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2695										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAGAAGATTTCTTGGTTATAC	0.343													16	27					1.15088e-07	1.32965e-07	1	1	0	A	118556647	C	A	118556647	3	1	48	1	0	0	0	0	1	0	0	0	4622	912	32	2	8227	2	DMXL1	5	118556647	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	71959	118556647	62358613	1494	5888										
SRFBP1	153443	broad.mit.edu	37	chr5	121355981	121355981	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaaaccaatacataattCaaaggaaaaaatagcaaaga	6	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:121355981C>A	ENST00000339397.4	+	6	623	c.551C>A	c.(550-552)tCa>tAa	p.S184*		NM_152546.2	NP_689759.2	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|skin(1)	15		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		ATACATAATTCAAAGGAAAAA	0.358													15	32					1.49906e-05	1.64923e-05	1	1	0	A	121355981	C	A	121355981	4	1	48	1	0	0	0	0	0	1	0	0	15199	838	29	2	573	2	SRFBP1	5	121355981	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2799334	121355981	59559279	1495	5889										
ZNF474	133923	broad.mit.edu	37	chr5	121487801	121487801	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctctagtgactcctattCtagcctttccccagaaacag	5	14	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:121487801C>A	ENST00000296600.4	+	2	499	c.116C>A	c.(115-117)tCt>tAt	p.S39Y	CTC-441N14.2_ENST00000504829.1_RNA|ZNF474_ENST00000514925.1_Intron	NM_207317.1	NP_997200.1	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	39						intracellular	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|stomach(1)	21		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		GACTCCTATTCTAGCCTTTCC	0.383													49	59					2.46787e-29	3.51135e-29	1	1	0	A	121487801	C	A	121487801	3	1	48	1	0	0	0	0	1	0	0	0	17988	913	32	2	118	2	ZNF474	5	121487801	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	131820	121487801	59427459	1496	5890										
SNCAIP	9627	broad.mit.edu	37	chr5	121761114	121761114	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacaatctattacatattgCggcgtcacagggacacgcag	9	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:121761114C>T	ENST00000261367.7	+	7	2639	c.1211C>T	c.(1210-1212)gCg>gTg	p.A404V	SNCAIP_ENST00000379536.2_Intron|SNCAIP_ENST00000261368.8_Missense_Mutation_p.A357V|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000503116.2_Missense_Mutation_p.A404V|SNCAIP_ENST00000379533.2_Missense_Mutation_p.A404V|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000504884.2_Silent_p.C66C			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	357					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TTACATATTGCGGCGTCACAG	0.453													41	96					0	0	1	0	0	T	121761114	C	T	121761114	3	4	48	1	0	0	0	0	1	0	0	0	14894	768	27	1	1084	1	SNCAIP	5	121761114	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	273313	121761114	59154146	1497	5891										
SNX2	6643	broad.mit.edu	37	chr5	122161826	122161826	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaaaaaacgtgaagctgaaGcaaaaatgatggttgctaac	9	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:122161826G>A	ENST00000379516.2	+	12	1402	c.1294G>A	c.(1294-1296)Gca>Aca	p.A432T	SNX2_ENST00000514949.1_Missense_Mutation_p.A315T|SNX2_ENST00000510372.1_3'UTR	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	432					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		TGAAGCTGAAGCAAAAATGAT	0.338													13	25					0	0	1	0	0	A	122161826	G	A	122161826	3	1	48	1	0	0	0	0	1	0	0	0	14944	971	34	3	1340	3	SNX2	5	122161826	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	400712	122161826	58753434	1498	5892										
SNX24	28966	broad.mit.edu	37	chr5	122281828	122281828	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaagtcttggaacagcgaCgacaaggcttggaaacatac	10	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:122281828C>T	ENST00000261369.4	+	3	408	c.223C>T	c.(223-225)Cga>Tga	p.R75*	SNX24_ENST00000506996.1_Nonsense_Mutation_p.R75*|SNX24_ENST00000511211.1_3'UTR|SNX24_ENST00000395451.4_Nonsense_Mutation_p.R108*|SNX24_ENST00000513881.1_Nonsense_Mutation_p.R75*	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	75	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		GGAACAGCGACGACAAGGCTT	0.343													11	20					0	0	1	0	0	T	122281828	C	T	122281828	4	4	48	1	0	0	0	0	0	1	0	0	14948	528	19	1	233	1	SNX24	5	122281828	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	120002	122281828	58633432	1499	5893										
PPIC	5480	broad.mit.edu	37	chr5	122364544	122364544	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacacgatgaaacttgcttCctttatatccatatcctttc	4	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:122364544C>T	ENST00000306442.4	-	3	366	c.251G>A	c.(250-252)gGa>gAa	p.G84E		NM_000943.4	NP_000934.1	P45877	PPIC_HUMAN	peptidylprolyl isomerase C (cyclophilin C)	84	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	6		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	AAACTTGCTTCCTTTATATCC	0.393													12	26					0	0	1	0	0	T	122364544	C	T	122364544	3	4	48	1	0	0	0	0	1	0	0	0	12368	855	30	3	399	3	PPIC	5	122364544	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	82716	122364544	58550716	1500	5894										
CSNK1G3	1456	broad.mit.edu	37	chr5	122927093	122927093	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacacagagataagatgcaAcaatccaaaaaccaggtttg	7	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:122927093A>G	ENST00000395412.1	+	10	1790	c.1071A>G	c.(1069-1071)caA>caG	p.Q357Q	CSNK1G3_ENST00000521364.1_Silent_p.Q357Q|CSNK1G3_ENST00000512718.3_Silent_p.Q282Q|CSNK1G3_ENST00000510842.2_Silent_p.Q358Q|CSNK1G3_ENST00000511130.2_Silent_p.Q245Q|CSNK1G3_ENST00000360683.2_Silent_p.Q357Q|CSNK1G3_ENST00000361991.2_Silent_p.Q357Q|CSNK1G3_ENST00000395411.1_Silent_p.Q357Q|CSNK1G3_ENST00000345990.4_Silent_p.Q357Q	NM_001044723.1	NP_001038188.1	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3	357					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(1)	15		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		ATAAGATGCAACAATCCAAAA	0.383													7	29					0	0	1	0	0	G	122927093	A	G	122927093	2	3	48	1	0	0	0	0	0	0	0	1	3981	40	2	4		4	CSNK1G3	5	122927093	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	562549	122927093	57988167	1501	5895										
ZNF608	57507	broad.mit.edu	37	chr5	123984088	123984089	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcattgttaaggcccttcINStttttgccagaattcttccc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:123984088_123984089insT	ENST00000306315.5	-	4	2423_2424	c.1988_1989insA	c.(1987-1989)aaafs	p.K663fs	ZNF608_ENST00000504926.1_Frame_Shift_Ins_p.K236fs	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	663						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TAAGGCCCTTCTTTTTGCCAGA	0.51													33	83	---	---	---	---						T	123984089	-	T	123984088	7	5	48	1	0	1	1	0	0	0	0	0	18090	912	32	0	2573	0	ZNF608	5	123984088	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	1056995	123984088	56931172	1502	5896										
C5orf48	389320	broad.mit.edu	37	chr5	125968261	125968261	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaagagattcatttgccacGattttcattaaagcaaggga	9	6	2	2	rs147526168	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:125968261G>A	ENST00000357147.3	+	2	123	c.110G>A	c.(109-111)cGa>cAa	p.R37Q		NM_207408.1	NP_997291.1	Q6ZNM6	CE048_HUMAN	chromosome 5 open reading frame 48	37										large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	7						CATTTGCCACGATTTTCATTA	0.393													7	18					0	0	1	0	0	A	125968261	G	A	125968261	3	1	48	1	0	0	0	0	1	0	0	0	2321	1058	37	1	116	1	C5orf48	5	125968261	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1984173	125968261	54946999	1503	5897										
LMNB1	4001	broad.mit.edu	37	chr5	126154643	126154643	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttggaaaggattcaagaAttagaggacttgcttgctaa	11	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:126154643A>G	ENST00000261366.5	+	6	1330	c.969A>G	c.(967-969)gaA>gaG	p.E323E	LMNB1_ENST00000395354.1_Silent_p.E323E|LMNB1_ENST00000460265.1_3'UTR	NM_001198557.1|NM_005573.3	NP_001185486.1|NP_005564.1	P20700	LMNB1_HUMAN	lamin B1	323	Coil 2.|Rod.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		GGATTCAAGAATTAGAGGACT	0.398													43	61					0	0	1	0	0	G	126154643	A	G	126154643	2	3	48	1	0	0	0	0	0	0	0	1	8889	98	4	4		4	LMNB1	5	126154643	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	186382	126154643	54760617	1504	5898										
ADAMTS19	171019	broad.mit.edu	37	chr5	128864216	128864216	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctctgttcttttgcagccaGaactatatattgggcatcat	8	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:128864216G>T	ENST00000274487.4	+	6	1301	c.1156G>T	c.(1156-1158)Gaa>Taa	p.E386*	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	386	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TTTGCAGCCAGAACTATATAT	0.333													15	16					1.05317e-09	1.27574e-09	1	1	0	T	128864216	G	T	128864216	4	4	48	1	0	0	0	0	0	1	0	0	263	943	33	2	1178	2	ADAMTS19	5	128864216	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2709573	128864216	52051044	1505	5899										
CHSY3	337876	broad.mit.edu	37	chr5	129521284	129521284	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctacaataaagtcattctaTctggcttaaggccattcaga	6	9	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:129521284T>C	ENST00000305031.4	+	3	2807	c.2449T>C	c.(2449-2451)Tct>Cct	p.S817P		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	817						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AGTCATTCTATCTGGCTTAAG	0.408													4	56					0	0	1	0	0	C	129521284	T	C	129521284	3	2	48	1	0	0	0	0	1	0	0	0	3435	1435	50	4	2459	4	CHSY3	5	129521284	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	657068	129521284	51393976	1506	5900										
KIF3A	11127	broad.mit.edu	37	chr5	132046653	132046653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttactaaacagaacttacccCttctttttttccttttctct	1	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:132046653C>T	ENST00000378746.4	-	9	1444	c.1226G>A	c.(1225-1227)aGg>aAg	p.R409K	KIF3A_ENST00000403231.1_Missense_Mutation_p.R409K|KIF3A_ENST00000378735.1_Missense_Mutation_p.R409K|AC004237.1_ENST00000431165.1_RNA	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	409				R -> RDQA (in Ref. 2; BAD93017).|R -> RDQT (in Ref. 4; AAH45542).|R -> RIQI (in Ref. 1; AAC72294).	blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAACTTACCCCTTCTTTTTTT	0.378													24	49					0	0	1	0	0	T	132046653	C	T	132046653	3	4	48	1	0	0	0	0	1	0	0	0	8341	681	24	3	909	3	KIF3A	5	132046653	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2525369	132046653	48868607	1507	5901										
CCNI2	645121	broad.mit.edu	37	chr5	132086667	132086667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggacctctatattgggaCgccgctggacttcttgacta	11	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:132086667C>T	ENST00000378731.1	+	4	803	c.752C>T	c.(751-753)aCg>aTg	p.T251M	CCNI2_ENST00000468733.1_3'UTR|SEPT8_ENST00000378719.2_3'UTR	NM_001039780.2	NP_001034869.1	Q6ZMN8	CCNI2_HUMAN	cyclin I family, member 2	251					regulation of cyclin-dependent protein kinase activity		protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|prostate(1)|urinary_tract(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TATATTGGGACGCCGCTGGAC	0.493													32	58					0	0	1	0	0	T	132086667	C	T	132086667	3	4	48	1	0	0	0	0	1	0	0	0	2949	536	19	1	766	1	CCNI2	5	132086667	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	40014	132086667	48828593	1508	5902										
SEPT8	23176	broad.mit.edu	37	chr5	132099413	132099413	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataccttgctgtctagtttCttcatggtcactagatctag	8	9	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:132099413C>A	ENST00000296873.7	-	4	802	c.519G>T	c.(517-519)aaG>aaT	p.K173N	SEPT8_ENST00000378701.1_Missense_Mutation_p.K171N|SEPT8_ENST00000458488.2_Missense_Mutation_p.K173N|SEPT8_ENST00000378721.4_Missense_Mutation_p.K171N|SEPT8_ENST00000378706.1_Missense_Mutation_p.K173N|SEPT8_ENST00000378719.2_Missense_Mutation_p.K173N|SEPT8_ENST00000448933.1_Missense_Mutation_p.K113N|SEPT8_ENST00000378699.2_Missense_Mutation_p.K113N	NM_001098812.1|NM_015146.1	NP_001092282.1|NP_055961.1	Q92599	SEPT8_HUMAN	septin 8	173					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTCTAGTTTCTTCATGGTCA	0.537													95	168					7.0627e-44	1.02276e-43	1	1	0	A	132099413	C	A	132099413	3	1	48	1	0	0	0	0	1	0	0	0	14123	912	32	2	1015	2	SEPT8	5	132099413	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12746	132099413	48815847	1509	5903										
GDF9	2661	broad.mit.edu	37	chr5	132197937	132197937	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtctttcatgcaagtaaAatttatagacatgtgaatac	7	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:132197937A>C	ENST00000378673.2	-	3	1575	c.709T>G	c.(709-711)Ttt>Gtt	p.F237V	GDF9_ENST00000296875.2_Missense_Mutation_p.F237V			O60383	GDF9_HUMAN	growth differentiation factor 9	237					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATGCAAGTAAAATTTATAGAC	0.403													28	45					0	0	1	0	0	C	132197937	A	C	132197937	3	2	48	1	0	0	0	0	1	0	0	0	6360	14	1	4	659	4	GDF9	5	132197937	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	98524	132197937	48717323	1510	5904										
HSPA4	3308	broad.mit.edu	37	chr5	132424107	132424107	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaaatagagttaaagaaaGaagatatttatgcagtggag	10	1	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:132424107G>T	ENST00000304858.2	+	9	1286	c.997G>T	c.(997-999)Gaa>Taa	p.E333*	HSPA4_ENST00000504328.1_3'UTR	NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	333					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTAAAGAAAGAAGATATTTA	0.308													11	15					3.07112e-06	3.42433e-06	1	1	0	T	132424107	G	T	132424107	4	4	48	1	0	0	0	0	0	1	0	0	7454	943	33	2	1031	2	HSPA4	5	132424107	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	226170	132424107	48491153	1511	5905										
FSTL4	23105	broad.mit.edu	37	chr5	132553062	132553062	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttttctctttgaggacaGatttcttcctgcaaaggaga	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:132553062G>T	ENST00000265342.7	-	13	1716	c.1467C>A	c.(1465-1467)atC>atA	p.I489I	CTB-49A3.2_ENST00000502776.1_RNA|CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	489						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTTGAGGACAGATTTCTTCCT	0.502													10	23					3.86212e-05	4.21111e-05	1	1	0	T	132553062	G	T	132553062	2	4	48	1	0	0	0	0	0	0	0	1	6113	932	33	2		2	FSTL4	5	132553062	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	128955	132553062	48362198	1512	5906										
TCF7	6932	broad.mit.edu	37	chr5	133481907	133481907	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacagataactctcttcactAttcctaggaggaaaaagaaa	6	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:133481907A>G	ENST00000321603.6	+	10	1287	c.1091A>G	c.(1090-1092)tAt>tGt	p.Y364C	TCF7_ENST00000520958.1_Intron|TCF7_ENST00000432532.2_Intron|TCF7_ENST00000395023.1_Intron|TCF7_ENST00000395029.1_Intron|TCF7_ENST00000378560.4_3'UTR|TCF7_ENST00000342854.5_Intron			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	0					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTCTTCACTATTCCTAGGAG	0.512											OREG0016787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	81	129					0	0	1	0	0	G	133481907	A	G	133481907	3	3	48	1	0	0	0	0	1	0	0	0	15755	464	16	4		4	TCF7	5	133481907	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	928845	133481907	47433353	1513	5907										
DDX46	9879	broad.mit.edu	37	chr5	134162645	134162645	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaatcactaggtgccaatGaactggctgtgcagaaagca	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:134162645G>T	ENST00000452510.2	+	22	3144	c.2986G>T	c.(2986-2988)Gaa>Taa	p.E996*	DDX46_ENST00000354283.4_Nonsense_Mutation_p.E995*	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	995					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGGTGCCAATGAACTGGCTGT	0.413													5	17					0.184627	0.185817	1	1	0	T	134162645	G	T	134162645	4	4	48	1	0	0	0	0	0	1	0	0	4387	1291	45	2	3069	2	DDX46	5	134162645	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	680738	134162645	46752615	1514	5908										
TGFBI	7045	broad.mit.edu	37	chr5	135383085	135383085	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccagcagatcattgagatCgaggacacctttgagaccct	9	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:135383085C>T	ENST00000442011.2	+	6	908	c.747C>T	c.(745-747)atC>atT	p.I249I	TGFBI_ENST00000305126.8_Silent_p.I249I	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	249	FAS1 2.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCATTGAGATCGAGGACACCT	0.572													90	159					0	0	1	0	0	T	135383085	C	T	135383085	2	4	48	1	0	0	0	0	0	0	0	1	15879	874	31	1		1	TGFBI	5	135383085	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1220440	135383085	45532175	1515	5909										
PKD2L2	27039	broad.mit.edu	37	chr5	137235410	137235410	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatataatgctaatgtaaatCtattttgtattatcaggtga	6	3	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137235410C>A	ENST00000508638.1	+	5	785	c.730C>A	c.(730-732)Cta>Ata	p.L244I	PKD2L2_ENST00000508883.1_Missense_Mutation_p.L244I|PKD2L2_ENST00000350250.4_Missense_Mutation_p.L210I|PKD2L2_ENST00000290431.5_Missense_Mutation_p.L244I|PKD2L2_ENST00000502810.1_Missense_Mutation_p.L244I	NM_001258449.1	NP_001245378.1	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	244						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TAATGTAAATCTATTTTGTAT	0.338													14	10					4.36969e-10	5.32873e-10	1	1	0	A	137235410	C	A	137235410	3	1	48	1	0	0	0	0	1	0	0	0	12015	912	32	2	748	2	PKD2L2	5	137235410	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1852325	137235410	43679850	1516	5910										
NME5	8382	broad.mit.edu	37	chr5	137454535	137454535	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctggtttttgcttacaaAgctctgtgagtccttcaagc	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137454535A>C	ENST00000265191.2	-	5	576	c.527T>G	c.(526-528)cTt>cGt	p.L176R		NM_003551.2	NP_003542.1	P56597	NDK5_HUMAN	NME/NM23 family member 5	176					anti-apoptosis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatid development|UTP biosynthetic process		ATP binding|nucleoside diphosphate kinase activity|protein binding			kidney(1)|large_intestine(1)|lung(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTGCTTACAAAGCTCTGTGAG	0.398													8	16					0	0	1	0	0	C	137454535	A	C	137454535	3	2	48	1	0	0	0	0	1	0	0	0	10540	72	3	4	119	4	NME5	5	137454535	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	219125	137454535	43460725	1517	5911										
BRD8	10902	broad.mit.edu	37	chr5	137476564	137476564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcttcaggctagttaagtCcatgggtctgcaggtggcca	12	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137476564C>T	ENST00000254900.5	-	26	3816	c.3445G>A	c.(3445-3447)Gac>Aac	p.D1149N		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1149	Bromo 2.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTAGTTAAGTCCATGGGTCTG	0.428													69	152					0	0	1	0	0	T	137476564	C	T	137476564	3	4	48	1	0	0	0	0	1	0	0	0	1508	855	30	3	270	3	BRD8	5	137476564	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22029	137476564	43438696	1518	5912										
BRD8	10902	broad.mit.edu	37	chr5	137488401	137488401	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcattgctcaactcagagtCattgggatgatcttgttcag	10	8	6	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137488401C>A	ENST00000254900.5	-	21	2997	c.2626G>T	c.(2626-2628)Gac>Tac	p.D876Y		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	876					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity	p.D876Y(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AACTCAGAGTCATTGGGATGA	0.458													8	109					0.27861	0.279356	1	1	0	A	137488401	C	A	137488401	3	1	48	1	0	0	0	0	1	0	0	0	1508	826	29	2	1109	2	BRD8	5	137488401	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11837	137488401	43426859	1519	5913										
KIF20A	10112	broad.mit.edu	37	chr5	137521258	137521258	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcaggaagccagacaacagTcagtggcccatcagcaatca	10	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137521258T>C	ENST00000394894.3	+	16	2210	c.1984T>C	c.(1984-1986)Tca>Cca	p.S662P	KIF20A_ENST00000508792.1_Missense_Mutation_p.S644P	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	662					cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGACAACAGTCAGTGGCCCA	0.517													50	72					0	0	1	0	0	C	137521258	T	C	137521258	3	2	48	1	0	0	0	0	1	0	0	0	8327	1667	58	4	2042	4	KIF20A	5	137521258	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	32857	137521258	43394002	1520	5914										
CDC23	8697	broad.mit.edu	37	chr5	137548851	137548851	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatctcaccatttgctacTgtgtagtaggccccgctccc	7	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137548851T>C	ENST00000394886.2	-	1	181	c.151A>G	c.(151-153)Agt>Ggt	p.S51G	CDC23_ENST00000394884.3_Missense_Mutation_p.S51G|CDC23_ENST00000505120.1_Missense_Mutation_p.S51G	NM_004661.3	NP_004652.2	Q9UJX2	CDC23_HUMAN	cell division cycle 23	51					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CATTTGCTACTGTGTAGTAGG	0.537													9	193					0	0	1	0	0	C	137548851	T	C	137548851	3	2	48	1	0	0	0	0	1	0	0	0	3083	1580	55	4	1706	4	CDC23	5	137548851	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	27593	137548851	43366409	1521	5915										
KDM3B	51780	broad.mit.edu	37	chr5	137754915	137754915	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagaaggctaaagaagaaAcaaaaggtgagatgcacaca	10	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:137754915A>G	ENST00000314358.5	+	14	3909	c.3709A>G	c.(3709-3711)Aca>Gca	p.T1237A	KDM3B_ENST00000508386.1_3'UTR|KDM3B_ENST00000394866.1_Missense_Mutation_p.T893A|KDM3B_ENST00000542866.1_Missense_Mutation_p.T269A	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1237					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TAAAGAAGAAACAAAAGGTGA	0.478													5	37					0	0	1	0	0	G	137754915	A	G	137754915	3	3	48	1	0	0	0	0	1	0	0	0	8170	43	2	4	3763	4	KDM3B	5	137754915	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	206064	137754915	43160345	1522	5916										
HARS	3035	broad.mit.edu	37	chr5	140057544	140057544	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaggatctcgcacatgatCttcaggcactctgcatcagg	9	13	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140057544C>A	ENST00000504366.1	-	5	2191	c.372G>T	c.(370-372)aaG>aaT	p.K124N	HARS_ENST00000504156.1_Missense_Mutation_p.K193N|HARS_ENST00000415192.2_Missense_Mutation_p.K119N|HARS_ENST00000438307.2_Missense_Mutation_p.K153N|HARS_ENST00000431330.2_Missense_Mutation_p.K79N|HARS_ENST00000307633.3_Missense_Mutation_p.K133N|HARS_ENST00000457527.2_Missense_Mutation_p.K173N|HARS_ENST00000448240.1_Missense_Mutation_p.K31N			P12081	SYHC_HUMAN	histidyl-tRNA synthetase	193					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	CGCACATGATCTTCAGGCACT	0.532													16	30					1.02788e-11	1.28326e-11	1	1	0	A	140057544	C	A	140057544	3	1	48	1	0	0	0	0	1	0	0	0	6999	912	32	2	982	2	HARS	5	140057544	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2302629	140057544	40857716	1523	5917										
PCDHA4	0	broad.mit.edu	37	chr5	140188074	140188074	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgagacgggggctcgccttcGctgtgggccacggccagtgt	17	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140188074G>A	ENST00000530339.1	+	1	1302	c.1302G>A	c.(1300-1302)tcG>tcA	p.S434S	PCDHA4_ENST00000356878.4_Silent_p.S434S|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Silent_p.S434S	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCGCCTTCGCTGTGGGCCA	0.612													93	144					0	0	1	0	0	A	140188074	G	A	140188074	2	1	48	1	0	0	0	0	0	0	0	1	11572	1074	38	1		1	PCDHA4	5	140188074	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	130530	140188074	40727186	1524	5918										
PCDHA7	0	broad.mit.edu	37	chr5	140215942	140215942	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggaccacggggagccctcGctgacagccacagccaccgt	12	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140215942G>A	ENST00000525929.1	+	1	1974	c.1974G>A	c.(1972-1974)tcG>tcA	p.S658S	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.S658S|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGCCCTCGCTGACAGCCA	0.657													33	77					0	0	1	0	0	A	140215942	G	A	140215942	2	1	48	1	0	0	0	0	0	0	0	1	11575	1074	38	1		1	PCDHA7	5	140215942	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	27868	140215942	40699318	1525	5919										
PCDHA9	0	broad.mit.edu	37	chr5	140229206	140229206	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgccctgattagtgtgatcGacctagacgcagatgccaac	10	11	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140229206G>A	ENST00000378122.3	+	1	1850	c.1126G>A	c.(1126-1128)Gac>Aac	p.D376N	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.D376N|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGTGTGATCGACCTAGACGC	0.512													41	108					0	0	1	0	0	A	140229206	G	A	140229206	3	1	48	1	0	0	0	0	1	0	0	0	11577	1058	37	1	1128	1	PCDHA9	5	140229206	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13264	140229206	40686054	1526	5920										
PCDHA9	0	broad.mit.edu	37	chr5	140229595	140229595	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgggcgagcgctcgctgtcGagctacgtgtcagtgcacgc	15	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140229595G>A	ENST00000378122.3	+	1	2239	c.1515G>A	c.(1513-1515)tcG>tcA	p.S505S	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.S505S|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCGCTGTCGAGCTACGTGT	0.677													55	122					0	0	1	0	0	A	140229595	G	A	140229595	2	1	48	1	0	0	0	0	0	0	0	1	11577	1045	37	1		1	PCDHA9	5	140229595	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	389	140229595	40685665	1527	5921										
PCDHA9	0	broad.mit.edu	37	chr5	140230511	140230511	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttatttatttatataattTtttttcttgaaagatattat	2	1	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140230511T>C	ENST00000378122.3	+	1	3155	c.2431T>C	c.(2431-2433)Ttt>Ctt	p.F811L	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ttatataattttttttCTTGA	0.353													46	64					0	0	1	0	0	C	140230511	T	C	140230511	3	2	48	1	0	0	0	0	1	0	0	0	11577	1841	64	4	2433	4	PCDHA9	5	140230511	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	916	140230511	40684749	1528	5922										
PCDHA11	0	broad.mit.edu	37	chr5	140249078	140249078	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggacattaacgacaacccGccggtgttctcgctcagaga	10	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140249078G>A	ENST00000398640.2	+	1	390	c.390G>A	c.(388-390)ccG>ccA	p.P130P	PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAACCCGCCGGTGTTCT	0.547													83	129					0	0	1	0	0	A	140249078	G	A	140249078	2	1	48	1	0	0	0	0	0	0	0	1	11567	1074	38	1		1	PCDHA11	5	140249078	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	18567	140249078	40666182	1529	5923										
PCDHA13	0	broad.mit.edu	37	chr5	140262568	140262568	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggacgtgaatgacaacGccccggaattttaccaatcc	8	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140262568G>A	ENST00000289272.2	+	1	715	c.715G>A	c.(715-717)Gcc>Acc	p.A239T	PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.A239T|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATGACAACGCCCCGGAATT	0.458													25	50					0	0	1	0	0	A	140262568	G	A	140262568	3	1	48	1	0	0	0	0	1	0	0	0	11569	1087	38	1	717	1	PCDHA13	5	140262568	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13490	140262568	40652692	1530	5924										
PCDHAC1	0	broad.mit.edu	37	chr5	140308918	140308918	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcaatgccatggtaagcaAattttatggaatttgattcc	8	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140308918A>C	ENST00000409700.3	+	1	2617	c.2441A>C	c.(2440-2442)aAa>aCa	p.K814T	PCDHAC1_ENST00000253807.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_031882.2	NP_114088.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGTAAGCAAATTTTATGGA	0.403													41	89					0	0	1	0	0	C	140308918	A	C	140308918	3	2	48	1	0	0	0	0	1	0	0	0	11578	14	1	4	2443	4	PCDHAC1	5	140308918	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	46350	140308918	40606342	1531	5925										
PCDHB1	0	broad.mit.edu	37	chr5	140433447	140433447	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggctccagtttgcccccaAattctgataggaataagtct	8	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140433447A>G	ENST00000306549.3	+	1	2469	c.2392A>G	c.(2392-2394)Aat>Gat	p.N798D		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		798					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGCCCCCAAATTCTGATAG	0.448													29	57					0	0	1	0	0	G	140433447	A	G	140433447	3	3	48	1	0	0	0	0	1	0	0	0	11580	14	1	4	2394	4	PCDHB1	5	140433447	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	124529	140433447	40481813	1532	5926										
PCDHB2	0	broad.mit.edu	37	chr5	140475653	140475653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatcaccatcaccgtcaccGacttcgggacacccaggctg	8	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140475653G>A	ENST00000194155.4	+	1	1427	c.1279G>A	c.(1279-1281)Gac>Aac	p.D427N		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		427	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCGTCACCGACTTCGGGAC	0.537													72	150					0	0	1	0	0	A	140475653	G	A	140475653	3	1	48	1	0	0	0	0	1	0	0	0	11588	1058	37	1	1281	1	PCDHB2	5	140475653	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42206	140475653	40439607	1533	5927										
PCDHB3	0	broad.mit.edu	37	chr5	140480258	140480258	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggcgggaggagagcgatttCttagacaaaggcaagtcttg	15	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140480258C>A	ENST00000231130.2	+	1	25	c.25C>A	c.(25-27)Ctt>Att	p.L9I	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		9					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGCGATTTCTTAGACAAAG	0.522													23	44					4.26978e-12	5.35675e-12	1	1	0	A	140480258	C	A	140480258	3	1	48	1	0	0	0	0	1	0	0	0	11589	913	32	2	27	2	PCDHB3	5	140480258	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4605	140480258	40435002	1534	5928										
PCDHB5	0	broad.mit.edu	37	chr5	140515755	140515755	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgaatttttacaatcattcTatgaggtacaggtgcccgag	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140515755T>C	ENST00000231134.5	+	1	956	c.739T>C	c.(739-741)Tat>Cat	p.Y247H		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		247	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAATCATTCTATGAGGTACA	0.522													25	275					0	0	1	0	0	C	140515755	T	C	140515755	3	2	48	1	0	0	0	0	1	0	0	0	11591	1522	53	4	741	4	PCDHB5	5	140515755	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	35497	140515755	40399505	1535	5929										
PCDHB10	0	broad.mit.edu	37	chr5	140572226	140572226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgggtttggacgttattCggtgactgaggaaacagaga	14	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140572226C>T	ENST00000239446.4	+	1	285	c.101C>T	c.(100-102)tCg>tTg	p.S34L		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		34					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACGTTATTCGGTGACTGAG	0.507													37	73					0	0	1	0	0	T	140572226	C	T	140572226	3	4	48	1	0	0	0	0	1	0	0	0	11581	893	31	1	103	1	PCDHB10	5	140572226	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	56471	140572226	40343034	1536	5930										
PCDHB14	0	broad.mit.edu	37	chr5	140603677	140603677	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtcctagatagagctttAgattatgaacaggaagctga	11	6	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140603677A>C	ENST00000239449.4	+	1	600	c.600A>C	c.(598-600)ttA>ttC	p.L200F	PCDHB14_ENST00000515856.2_Missense_Mutation_p.L47F	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		200	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAGAGCTTTAGATTATGAAC	0.443													36	53					0	0	1	0	0	C	140603677	A	C	140603677	3	2	48	1	0	0	0	0	1	0	0	0	11585	417	15	4	602	4	PCDHB14	5	140603677	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	31451	140603677	40311583	1537	5931										
PCDHB15	0	broad.mit.edu	37	chr5	140627280	140627280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttcctgttcgtggcagtgCggctgtgcaggaggagcagg	18	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140627280C>T	ENST00000231173.3	+	1	2134	c.2134C>T	c.(2134-2136)Cgg>Tgg	p.R712W		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		712					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTGGCAGTGCGGCTGTGCAG	0.672													83	168					0	0	1	0	0	T	140627280	C	T	140627280	3	4	48	1	0	0	0	0	1	0	0	0	11586	759	27	1	2136	1	PCDHB15	5	140627280	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23603	140627280	40287980	1538	5932										
PCDHGA2	0	broad.mit.edu	37	chr5	140718783	140718783	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctctgaacccgcgaagcgGcagcttggtcactgcgaaca	12	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140718783G>A	ENST00000394576.2	+	1	245	c.245G>A	c.(244-246)gGc>gAc	p.G82D	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCGAAGCGGCAGCTTGGTC	0.572													47	99					0	0	1	0	0	A	140718783	G	A	140718783	3	1	48	1	0	0	0	0	1	0	0	0	11600	1203	42	3	247	3	PCDHGA2	5	140718783	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	91503	140718783	40196477	1539	5933										
PCDHGA2	0	broad.mit.edu	37	chr5	140720038	140720038	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacactgttcagggggcaccCttatcctcttacatctctat	7	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140720038C>T	ENST00000394576.2	+	1	1500	c.1500C>T	c.(1498-1500)ccC>ccT	p.P500P	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGGGCACCCTTATCCTCTT	0.517													41	95					0	0	1	0	0	T	140720038	C	T	140720038	2	4	48	1	0	0	0	0	0	0	0	1	11600	668	24	3		3	PCDHGA2	5	140720038	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1255	140720038	40195222	1540	5934										
PCDHGB1	0	broad.mit.edu	37	chr5	140730012	140730012	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtccgggagttgccaactcGaaaactgcgggttagtgcag	14	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140730012G>A	ENST00000523390.1	+	1	185	c.185G>A	c.(184-186)cGa>cAa	p.R62Q	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGCCAACTCGAAAACTGCGG	0.522											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	30					0	0	1	0	0	A	140730012	G	A	140730012	3	1	48	1	0	0	0	0	1	0	0	0	11608	1058	37	1	187	1	PCDHGB1	5	140730012	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9974	140730012	40185248	1541	5935										
PCDHGB2	0	broad.mit.edu	37	chr5	140740546	140740546	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagagatcacctactcctttCataatgtggacgaacaagtg	8	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140740546C>A	ENST00000522605.1	+	1	844	c.844C>A	c.(844-846)Cat>Aat	p.H282N	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACTCCTTTCATAATGTGGA	0.453													4	32					0.00909568	0.00935351	1	1	0	A	140740546	C	A	140740546	3	1	48	1	0	0	0	0	1	0	0	0	11609	826	29	2	846	2	PCDHGB2	5	140740546	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10534	140740546	40174714	1542	5936										
PCDHGB3	0	broad.mit.edu	37	chr5	140750455	140750455	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatcctgatgtaggtgtcaAttcgctgcagcagtactacc	10	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140750455A>C	ENST00000576222.1	+	1	625	c.494A>C	c.(493-495)aAt>aCt	p.N165T	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAGGTGTCAATTCGCTGCAG	0.498													81	166					0	0	1	0	0	C	140750455	A	C	140750455	3	2	48	1	0	0	0	0	1	0	0	0	11610	101	4	4	496	4	PCDHGB3	5	140750455	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	9909	140750455	40164805	1543	5937										
PCDHGB3	0	broad.mit.edu	37	chr5	140752101	140752101	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgattctggcaatctccctgCgcctgcgatgctcctccaga	9	15	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140752101C>T	ENST00000576222.1	+	1	2271	c.2140C>T	c.(2140-2142)Cgc>Tgc	p.R714C	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATCTCCCTGCGCCTGCGATG	0.582													20	32					0	0	1	0	0	T	140752101	C	T	140752101	3	4	48	1	0	0	0	0	1	0	0	0	11610	768	27	1	2142	1	PCDHGB3	5	140752101	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1646	140752101	40163159	1544	5938										
PCDHGA6	0	broad.mit.edu	37	chr5	140754335	140754335	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcaagcgtcgcccaaattCtggtaacagttctagatgtg	10	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140754335C>A	ENST00000517434.1	+	1	685	c.685C>A	c.(685-687)Ctg>Atg	p.L229M	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCAAATTCTGGTAACAGT	0.542													14	21					6.31663e-08	7.35827e-08	1	1	0	A	140754335	C	A	140754335	3	1	48	1	0	0	0	0	1	0	0	0	11604	912	32	2	687	2	PCDHGA6	5	140754335	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2234	140754335	40160925	1545	5939										
PCDHGA8	0	broad.mit.edu	37	chr5	140773529	140773529	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaaagaatggtcaagttgtCtgttacacacgtgataattt	10	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140773529C>A	ENST00000398604.2	+	1	1149	c.1149C>A	c.(1147-1149)gtC>gtA	p.V383V	PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAAGTTGTCTGTTACACAC	0.363													16	26					2.32078e-09	2.7896e-09	1	1	0	A	140773529	C	A	140773529	2	1	48	1	0	0	0	0	0	0	0	1	11606	900	32	2		2	PCDHGA8	5	140773529	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19194	140773529	40141731	1546	5940										
PCDHGA9	0	broad.mit.edu	37	chr5	140784372	140784372	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtgagccagggctcttctCggtggggctgcacacaggtg	16	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140784372C>T	ENST00000573521.1	+	1	1853	c.1853C>T	c.(1852-1854)tCg>tTg	p.S618L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTCTTCTCGGTGGGGCTG	0.602													38	49					0	0	1	0	0	T	140784372	C	T	140784372	3	4	48	1	0	0	0	0	1	0	0	0	11607	893	31	1	1855	1	PCDHGA9	5	140784372	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10843	140784372	40130888	1547	5941										
PCDHGA12	0	broad.mit.edu	37	chr5	140811516	140811516	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccctttaaattagaaaaatCttacggaaattactatagtt	5	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140811516C>A	ENST00000252085.3	+	1	1332	c.1190C>A	c.(1189-1191)tCt>tAt	p.S397Y	PCDHGB7_ENST00000398594.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAGAAAAATCTTACGGAAAT	0.413													22	39					5.26018e-13	6.70247e-13	1	1	0	A	140811516	C	A	140811516	3	1	48	1	0	0	0	0	1	0	0	0	11599	913	32	2	1192	2	PCDHGA12	5	140811516	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	27144	140811516	40103744	1548	5942										
PCDHGC3	0	broad.mit.edu	37	chr5	140858062	140858062	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacacgctgcggagctgtgaTccggtgttctataggcaggt	14	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140858062T>C	ENST00000308177.3	+	1	2483	c.2379T>C	c.(2377-2379)gaT>gaC	p.D793D	PCDHGB7_ENST00000398594.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTGTGATCCGGTGTTCT	0.582											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	15					0	0	1	0	0	C	140858062	T	C	140858062	2	2	48	1	0	0	0	0	0	0	0	1	11615	1432	50	4		4	PCDHGC3	5	140858062	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	46546	140858062	40057198	1549	5943										
DIAPH1	1729	broad.mit.edu	37	chr5	140951545	140951545	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggcgaaaagttcattgttCtcaaagcggtcctccttcac	8	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:140951545C>T	ENST00000253811.6	-	17	2561	c.2421G>A	c.(2419-2421)gaG>gaA	p.E807E	DIAPH1_ENST00000520569.1_Silent_p.E753E|DIAPH1_ENST00000398557.4_Silent_p.E807E|DIAPH1_ENST00000398566.3_Silent_p.E798E|DIAPH1_ENST00000389057.5_Silent_p.E798E|DIAPH1_ENST00000398562.2_Silent_p.E786E|DIAPH1_ENST00000389054.3_Silent_p.E807E|DIAPH1_ENST00000518047.1_Silent_p.E798E			O60610	DIAP1_HUMAN	diaphanous-related formin 1	807	FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCATTGTTCTCAAAGCGGT	0.478													32	58					0	0	1	0	0	T	140951545	C	T	140951545	2	4	48	1	0	0	0	0	0	0	0	1	4546	912	32	3		3	DIAPH1	5	140951545	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93483	140951545	39963715	1550	5944										
ARAP3	64411	broad.mit.edu	37	chr5	141035789	141035789	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggctttaacttcttgcggaTtcccaggtagaccttggcac	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:141035789T>C	ENST00000239440.4	-	28	3909	c.3844A>G	c.(3844-3846)Atc>Gtc	p.I1282V	ARAP3_ENST00000513878.1_Missense_Mutation_p.I944V|ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000508305.1_Missense_Mutation_p.I1113V	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1282	PH 3.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TTCTTGCGGATTCCCAGGTAG	0.557													52	80					0	0	1	0	0	C	141035789	T	C	141035789	3	2	48	1	0	0	0	0	1	0	0	0	837	1493	52	4	814	4	ARAP3	5	141035789	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	84244	141035789	39879471	1551	5945										
PCDH12	51294	broad.mit.edu	37	chr5	141325152	141325152	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttccagcagcatctccaGcagtgagctcatctccgaga	9	14	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:141325152G>T	ENST00000231484.3	-	4	4559	c.3349C>A	c.(3349-3351)Ctg>Atg	p.L1117M		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	1117					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCATCTCCAGCAGTGAGCTC	0.647													29	38					3.00307e-07	3.44266e-07	1	1	0	T	141325152	G	T	141325152	3	4	48	1	0	0	0	0	1	0	0	0	11556	962	34	5	209	5	PCDH12	5	141325152	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	289363	141325152	39590108	1552	5946										
PCDH12	51294	broad.mit.edu	37	chr5	141335924	141335924	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caactggggagtcctggatgCggtatgagacttttccatta	12	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:141335924C>T	ENST00000231484.3	-	1	2703	c.1493G>A	c.(1492-1494)cGc>cAc	p.R498H		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	498	Cadherin 5.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTGGATGCGGTATGAGAC	0.483													21	41					0	0	1	0	0	T	141335924	C	T	141335924	3	4	48	1	0	0	0	0	1	0	0	0	11556	768	27	1	2077	1	PCDH12	5	141335924	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10772	141335924	39579336	1553	5947										
NDFIP1	80762	broad.mit.edu	37	chr5	141524180	141524180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcaattatgcaaaagttCggaagatgccagaaactttc	7	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:141524180C>T	ENST00000253814.4	+	7	1077	c.607C>T	c.(607-609)Cgg>Tgg	p.R203W		NM_030571.3	NP_085048.1	Q9BT67	NFIP1_HUMAN	Nedd4 family interacting protein 1	203					cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endosome membrane|extracellular region|Golgi membrane|integral to membrane|perinuclear region of cytoplasm	signal transducer activity			large_intestine(3)|lung(1)|ovary(1)	5		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAAAAGTTCGGAAGATGCC	0.323													37	71					0	0	1	0	0	T	141524180	C	T	141524180	3	4	48	1	0	0	0	0	1	0	0	0	10291	875	31	1	633	1	NDFIP1	5	141524180	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	188256	141524180	39391080	1554	5948										
ARHGAP26	23092	broad.mit.edu	37	chr5	142150427	142150427	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagctggacaagaccaacaAattcatcaaggagctcatca	8	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:142150427A>C	ENST00000378004.3	+	1	456	c.101A>C	c.(100-102)aAa>aCa	p.K34T	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.K34T	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	34					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGACCAACAAATTCATCAAG	0.607													30	50					0	0	1	0	0	C	142150427	A	C	142150427	3	2	48	1	0	0	0	0	1	0	0	0	872	14	1	4	103	4	ARHGAP26	5	142150427	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	626247	142150427	38764833	1555	5949										
SH3RF2	153769	broad.mit.edu	37	chr5	145393376	145393376	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcatcccgcacaaaaaacCtgtccctggtgtcctcgtcc	7	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:145393376C>A	ENST00000511217.1	+	4	863	c.811C>A	c.(811-813)Ctg>Atg	p.L271M	SH3RF2_ENST00000359120.4_Missense_Mutation_p.L271M			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	271							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACAAAAAACCTGTCCCTGGT	0.537													27	70					2.44723e-14	3.18537e-14	1	1	0	A	145393376	C	A	145393376	3	1	48	1	0	0	0	0	1	0	0	0	14313	680	24	5	825	5	SH3RF2	5	145393376	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3242949	145393376	35521884	1556	5950										
PPP2R2B	5521	broad.mit.edu	37	chr5	146077608	146077608	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttattttattgattttttCttctatttctaaactcttca	1	7	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:146077608C>A	ENST00000394413.3	-	3	838	c.268G>T	c.(268-270)Gaa>Taa	p.E90*	PPP2R2B_ENST00000336640.6_Nonsense_Mutation_p.E93*|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000504198.1_Nonsense_Mutation_p.E96*|PPP2R2B_ENST00000508545.2_Nonsense_Mutation_p.E79*|PPP2R2B_ENST00000394411.4_Nonsense_Mutation_p.E90*|PPP2R2B_ENST00000356826.3_Nonsense_Mutation_p.E90*|PPP2R2B_ENST00000394409.3_Nonsense_Mutation_p.E148*|PPP2R2B_ENST00000453001.1_Nonsense_Mutation_p.E90*|PPP2R2B_ENST00000394410.2_Nonsense_Mutation_p.E79*|PPP2R2B_ENST00000394414.1_Nonsense_Mutation_p.E156*			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	90					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGATTTTTTCTTCTATTTCT	0.388													19	41					5.35267e-07	6.09026e-07	1	1	0	A	146077608	C	A	146077608	4	1	48	1	0	0	0	0	0	1	0	0	12433	922	32	2	1091	2	PPP2R2B	5	146077608	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	684232	146077608	34837652	1557	5951										
STK32A	202374	broad.mit.edu	37	chr5	146722600	146722600	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgacaatattttacttgacGaacatggtaagtgagtgatt	9	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:146722600G>A	ENST00000397936.3	+	6	799	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	STK32A_ENST00000398523.3_Missense_Mutation_p.E156K|STK32A_ENST00000541094.1_Missense_Mutation_p.E156K|STK32A_ENST00000398521.3_Missense_Mutation_p.E156K	NM_001112724.1	NP_001106195.1	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A	156	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACTTGACGAACATGGTAA	0.373													27	57					0	0	1	0	0	A	146722600	G	A	146722600	3	1	48	1	0	0	0	0	1	0	0	0	15352	1059	37	1	484	1	STK32A	5	146722600	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	644992	146722600	34192660	1558	5952										
JAKMIP2	9832	broad.mit.edu	37	chr5	147030017	147030017	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgttcgtccaaagcctcctTctgaagttggagtttctgta	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:147030017T>C	ENST00000265272.5	-	4	1188	c.721A>G	c.(721-723)Aag>Gag	p.K241E	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.K199E|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.K241E	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	241						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAGCCTCCTTCTGAAGTTGG	0.478													12	49					0	0	1	0	0	C	147030017	T	C	147030017	3	2	48	1	0	0	0	0	1	0	0	0	7984	1792	62	4	1783	4	JAKMIP2	5	147030017	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	307417	147030017	33885243	1559	5953										
SPINK5	11005	broad.mit.edu	37	chr5	147491427	147491427	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctagatgggaaaatccacGgcaacacctgctccatgtgt	10	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:147491427G>T	ENST00000359874.3	+	19	1862	c.1789G>T	c.(1789-1791)Ggc>Tgc	p.G597C	SPINK5_ENST00000398454.1_Missense_Mutation_p.G597C|SPINK5_ENST00000256084.7_Missense_Mutation_p.G597C	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	597	Kazal-like 9.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity	p.G597C(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAATCCACGGCAACACCTG	0.537													29	44					3.73148e-12	4.68978e-12	1	1	0	T	147491427	G	T	147491427	3	4	48	1	0	0	0	0	1	0	0	0	15117	1116	39	5	1863	5	SPINK5	5	147491427	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	461410	147491427	33423833	1560	5954										
HTR4	3360	broad.mit.edu	37	chr5	147830815	147830815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcgagttcctgatgatgtCccctgtgcagaacggtgtac	11	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:147830815C>T	ENST00000354217.2	-	7	1260	c.1097G>A	c.(1096-1098)gGa>gAa	p.G366E	HTR4_ENST00000521530.1_Missense_Mutation_p.G366E|HTR4_ENST00000314512.6_3'UTR|HTR4_ENST00000521735.1_3'UTR			Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	0					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	CTGATGATGTCCCCTGTGCAG	0.478													54	89					0	0	1	0	0	T	147830815	C	T	147830815	3	4	48	1	0	0	0	0	1	0	0	0	7492	855	30	3	70	3	HTR4	5	147830815	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	339388	147830815	33084445	1561	5955										
HTR4	3360	broad.mit.edu	37	chr5	147863828	147863828	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaatcatagttaccccaaGacaggcttccttgcagtcaa	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:147863828G>T	ENST00000360693.3	-	7	1329	c.1191C>A	c.(1189-1191)gtC>gtA	p.V397V	HTR4_ENST00000521530.1_Intron|HTR4_ENST00000377888.3_Intron|HTR4_ENST00000354217.2_Intron|HTR4_ENST00000314512.6_Intron|HTR4_ENST00000362016.2_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000517929.1_Intron	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	359					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	gttaccccaagacaggcttcc	0.408													10	14					1.08611e-07	1.25818e-07	1	1	0	T	147863828	G	T	147863828	2	4	48	1	0	0	0	0	0	0	0	1	7492	929	33	2		2	HTR4	5	147863828	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	33013	147863828	33051432	1562	5956										
HTR4	3360	broad.mit.edu	37	chr5	147929810	147929810	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accaccttctccactgacccGaaaccctcctcagaactgaa	4	18	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:147929810G>A	ENST00000360693.3	-	3	180	c.42C>T	c.(40-42)ttC>ttT	p.F14F	HTR4_ENST00000521530.1_Silent_p.F14F|HTR4_ENST00000377888.3_Silent_p.F14F|HTR4_ENST00000354217.2_Silent_p.F14F|HTR4_ENST00000314512.6_Silent_p.F14F|HTR4_ENST00000362016.2_Silent_p.F14F|HTR4_ENST00000519495.1_5'UTR|HTR4_ENST00000521735.1_Silent_p.F14F|HTR4_ENST00000520514.1_Silent_p.F14F|HTR4_ENST00000517929.1_Silent_p.F14F	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	14					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	CCACTGACCCGAAACCCTCCT	0.493													23	54					0	0	1	0	0	A	147929810	G	A	147929810	2	1	48	1	0	0	0	0	0	0	0	1	7492	1049	37	1		1	HTR4	5	147929810	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65982	147929810	32985450	1563	5957										
GRPEL2	134266	broad.mit.edu	37	chr5	148730559	148730559	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtgcatttctgaagaatCggagcctgaggaccaaaagc	12	8	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:148730559C>T	ENST00000329271.3	+	4	502	c.392C>T	c.(391-393)tCg>tTg	p.S131L	GRPEL2_ENST00000507562.1_3'UTR|GRPEL2_ENST00000416916.2_Missense_Mutation_p.R104W|RP11-394O4.4_ENST00000521295.1_RNA	NM_152407.3	NP_689620.2	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial (E. coli)	131					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGAAGAATCGGAGCCTGAG	0.473													46	87					0	0	1	0	0	T	148730559	C	T	148730559	3	4	48	1	0	0	0	0	1	0	0	0	6847	893	31	1	406	1	GRPEL2	5	148730559	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	800749	148730559	32184701	1564	5958										
PDE6A	5145	broad.mit.edu	37	chr5	149264383	149264383	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccaaactccaagtggtgtCtttccaagatagaggaccca	9	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:149264383C>A	ENST00000255266.5	-	15	2005	c.1886G>T	c.(1885-1887)aGa>aTa	p.R629I		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	629					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CAAGTGGTGTCTTTCCAAGAT	0.502													19	35					1.01871e-10	1.25646e-10	1	1	0	A	149264383	C	A	149264383	3	1	48	1	0	0	0	0	1	0	0	0	11691	913	32	2	728	2	PDE6A	5	149264383	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	533824	149264383	31650877	1565	5959										
SLC26A2	1836	broad.mit.edu	37	chr5	149360083	149360083	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgatcttatcaccagcctTttgtgccttttggttctttt	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:149360083T>G	ENST00000286298.4	+	3	1195	c.927T>G	c.(925-927)ctT>ctG	p.L309L		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	309						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TCACCAGCCTTTTGTGCCTTT	0.428													11	43					0	0	1	0	0	G	149360083	T	G	149360083	2	3	48	1	0	0	0	0	0	0	0	1	14571	1828	64	4		4	SLC26A2	5	149360083	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	95700	149360083	31555177	1566	5960										
CSF1R	1436	broad.mit.edu	37	chr5	149435833	149435833	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatgtccctagccagcccGaagtccccaatcttggccac	8	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:149435833G>A	ENST00000286301.3	-	18	2682	c.2391C>T	c.(2389-2391)ttC>ttT	p.F797F		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	797	Protein kinase.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TAGCCAGCCCGAAGTCCCCAA	0.572													35	81					0	0	1	0	0	A	149435833	G	A	149435833	2	1	48	1	0	0	0	0	0	0	0	1	3957	1049	37	1		1	CSF1R	5	149435833	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	75750	149435833	31479427	1567	5961										
RPS14	6208	broad.mit.edu	37	chr5	149826514	149826514	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatcccaccagtcacacgGcagatggtttccctggggac	10	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:149826514G>A	ENST00000401695.3	-	3	208	c.162C>T	c.(160-162)tgC>tgT	p.C54C	RPS14_ENST00000312037.5_Silent_p.C54C|RPS14_ENST00000407193.1_Silent_p.C54C			P62263	RS14_HUMAN	ribosomal protein S14	54					endocrine pancreas development|erythrocyte differentiation|maturation of SSU-rRNA|negative regulation of transcription from RNA polymerase II promoter|ribosomal small subunit assembly|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA 5'-UTR binding|protein binding|structural constituent of ribosome|translation regulator activity			central_nervous_system(1)|lung(1)|skin(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGTCACACGGCAGATGGTTT	0.522													23	56					0	0	1	0	0	A	149826514	G	A	149826514	2	1	48	1	0	0	0	0	0	0	0	1	13675	1195	42	3		3	RPS14	5	149826514	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	390681	149826514	31088746	1568	5962										
SYNPO	11346	broad.mit.edu	37	chr5	150028210	150028210	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcagaggcccaactcccaTctaatggcacagggcctgct	9	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:150028210T>C	ENST00000394243.1	+	3	1479	c.1105T>C	c.(1105-1107)Tct>Cct	p.S369P	SYNPO_ENST00000522122.1_Missense_Mutation_p.S369P|SYNPO_ENST00000307662.4_Missense_Mutation_p.S125P|SYNPO_ENST00000518872.1_3'UTR|SYNPO_ENST00000519664.1_Missense_Mutation_p.S125P	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	369					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAACTCCCATCTAATGGCAC	0.572													29	190					0	0	1	0	0	C	150028210	T	C	150028210	3	2	48	1	0	0	0	0	1	0	0	0	15512	1435	50	4	1111	4	SYNPO	5	150028210	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	201696	150028210	30887050	1569	5963										
DCTN4	51164	broad.mit.edu	37	chr5	150099289	150099289	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtactaaccttcatgtagcGaaggttgggaattgacatga	12	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:150099289G>A	ENST00000447998.2	-	10	1067	c.952C>T	c.(952-954)Cgc>Tgc	p.R318C	DCTN4_ENST00000424236.1_Missense_Mutation_p.R261C|DCTN4_ENST00000446090.2_Missense_Mutation_p.R325C	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	318						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCATGTAGCGAAGGTTGGGA	0.348													12	19					0	0	1	0	0	A	150099289	G	A	150099289	3	1	48	1	0	0	0	0	1	0	0	0	4332	1058	37	1	446	1	DCTN4	5	150099289	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	71079	150099289	30815971	1570	5964										
ZNF300	91975	broad.mit.edu	37	chr5	150278113	150278113	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatccttgaatgatactaAcccctgtaatagtaaattcc	4	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:150278113A>G	ENST00000427179.1	-	4	245	c.19T>C	c.(19-21)Tta>Cta	p.L7L	ZNF300_ENST00000418587.2_5'UTR|ZNF300_ENST00000446148.2_Silent_p.L23L|ZNF300_ENST00000394226.2_Silent_p.L7L|ZNF300_ENST00000274599.5_Silent_p.L7L			Q96RE9	ZN300_HUMAN	zinc finger protein 300	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)	27		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATGATACTAACCCCTGTAAT	0.418													17	91					0	0	1	0	0	G	150278113	A	G	150278113	2	3	48	1	0	0	0	0	0	0	0	1	17887	40	2	4		4	ZNF300	5	150278113	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	178824	150278113	30637147	1571	5965										
SLC36A2	153201	broad.mit.edu	37	chr5	150696383	150696383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagcagtgccaggctcaccGaacaaaagtggtggagttgg	16	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:150696383G>A	ENST00000335244.4	-	10	1576	c.1447C>T	c.(1447-1449)Cgg>Tgg	p.R483W	SLC36A2_ENST00000450886.1_Missense_Mutation_p.R207W	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	483					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGGCTCACCGAACAAAAGTG	0.483													21	57					0	0	1	0	0	A	150696383	G	A	150696383	3	1	48	1	0	0	0	0	1	0	0	0	14648	1057	37	1	8	1	SLC36A2	5	150696383	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	418270	150696383	30218877	1572	5966										
SLC36A1	206358	broad.mit.edu	37	chr5	150858923	150858923	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtactccatcgggatcttTttcacctacgcactccagtt	6	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:150858923T>G	ENST00000243389.3	+	10	1255	c.1032T>G	c.(1030-1032)ttT>ttG	p.F344L	SLC36A1_ENST00000520701.1_Missense_Mutation_p.F344L|SLC36A1_ENST00000521925.1_Missense_Mutation_p.F344L	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	344					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TCGGGATCTTTTTCACCTACG	0.522													23	58					0	0	1	0	0	G	150858923	T	G	150858923	3	3	48	1	0	0	0	0	1	0	0	0	14647	1838	64	4	1066	4	SLC36A1	5	150858923	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	162540	150858923	30056337	1573	5967										
FAT2	2196	broad.mit.edu	37	chr5	150942953	150942953	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgttgaaggtcagcttcccTttggagctggagtctgggtc	14	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:150942953T>G	ENST00000261800.5	-	2	3519	c.3507A>C	c.(3505-3507)aaA>aaC	p.K1169N		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1169	Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAGCTTCCCTTTGGAGCTGG	0.527													5	71					0	0	1	0	0	G	150942953	T	G	150942953	3	3	48	1	0	0	0	0	1	0	0	0	5722	1606	56	4	9630	4	FAT2	5	150942953	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	84030	150942953	29972307	1574	5968										
SPARC	6678	broad.mit.edu	37	chr5	151052738	151052738	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctgcaccatcatcaaattCtcctacttccacctggacag	4	16	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:151052738C>A	ENST00000231061.4	-	4	473	c.160G>T	c.(160-162)Gaa>Taa	p.E54*		NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	54	Asp/Glu-rich (acidic; binds calcium).				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	TCATCAAATTCTCCTACTTCC	0.537													15	96					3.27435e-08	3.83577e-08	1	1	0	A	151052738	C	A	151052738	4	1	48	1	0	0	0	0	0	1	0	0	15050	922	32	2	779	2	SPARC	5	151052738	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	109785	151052738	29862522	1575	5969										
GLRA1	2741	broad.mit.edu	37	chr5	151202492	151202492	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggcccatcccataggcagaGaagttaaagcggccttctcc	11	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:151202492G>T	ENST00000274576.4	-	9	1384	c.1092C>A	c.(1090-1092)ttC>ttA	p.F364L	GLRA1_ENST00000545569.1_Missense_Mutation_p.F281L|GLRA1_ENST00000455880.2_Missense_Mutation_p.F372L	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	372					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATAGGCAGAGAAGTTAAAGC	0.547													18	40					5.03518e-11	6.23768e-11	1	1	0	T	151202492	G	T	151202492	3	4	48	1	0	0	0	0	1	0	0	0	6495	933	33	2	261	2	GLRA1	5	151202492	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	149754	151202492	29712768	1576	5970										
LARP1	23367	broad.mit.edu	37	chr5	154179268	154179268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagactgatttctcccagCttctcaactgccctgaattt	5	14	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:154179268C>T	ENST00000336314.4	+	9	1288	c.1264C>T	c.(1264-1266)Ctt>Ttt	p.L422F		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	499	HTH La-type RNA-binding.						protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTCTCCCAGCTTCTCAACTG	0.507													35	88					0	0	1	0	0	T	154179268	C	T	154179268	3	4	48	1	0	0	0	0	1	0	0	0	8666	797	28	3	1298	3	LARP1	5	154179268	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2976776	154179268	26735992	1577	5971										
LARP1	23367	broad.mit.edu	37	chr5	154183841	154183841	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggtgatggattcccgtgaGcacaggccccgtactgcttc	13	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:154183841G>T	ENST00000336314.4	+	14	2313	c.2289G>T	c.(2287-2289)gaG>gaT	p.E763D		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	840							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATTCCCGTGAGCACAGGCCCC	0.567													38	75					1.56738e-10	1.93275e-10	1	1	0	T	154183841	G	T	154183841	3	4	48	1	0	0	0	0	1	0	0	0	8666	962	34	5	2343	5	LARP1	5	154183841	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4573	154183841	26731419	1578	5972										
KIF4B	285643	broad.mit.edu	37	chr5	154394020	154394020	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaacaactctaggactgtgGcctccacagctatgaactcc	8	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:154394020G>A	ENST00000435029.4	+	1	761	c.601G>A	c.(601-603)Gcc>Acc	p.A201T		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	201	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAGGACTGTGGCCTCCACAGC	0.458													11	100					0	0	1	0	0	A	154394020	G	A	154394020	3	1	48	1	0	0	0	0	1	0	0	0	8345	1203	42	3	603	3	KIF4B	5	154394020	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	210179	154394020	26521240	1579	5973										
KIF4B	285643	broad.mit.edu	37	chr5	154396021	154396021	+	Frame_Shift_Del	DEL	A	A	-													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaagccaagtgtgccctgAaatatttgattggagagctg							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:154396021delA	ENST00000435029.4	+	1	2762	c.2602delA	c.(2602-2604)aafs	p.K868fs		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	868	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTGTGCCCTGAAATATTTGAT	0.473													25	49	---	---	---	---						-	154396021	A	-	154396021	7	5	48	1	0	1	0	1	0	0	0	0	8345	247	9	0	2604	0	KIF4B	5	154396021	Frame_Shift_Del	DEL	A	TCGA-ND-A4WC-01A-21D-A28R-08	2001	154396021	26519239	1580	5974										
FAM71B	153745	broad.mit.edu	37	chr5	156593022	156593022	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctccctttttgtttatcTgaataaaattactctcgaac	3	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:156593022T>G	ENST00000302938.4	-	1	253	c.158A>C	c.(157-159)cAg>cCg	p.Q53P		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	53						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTGTTTATCTGAATAAAATT	0.478													7	78					0	0	1	0	0	G	156593022	T	G	156593022	3	3	48	1	0	0	0	0	1	0	0	0	5642	1580	55	4	1667	4	FAM71B	5	156593022	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2197001	156593022	24322238	1581	5975										
ITK	3702	broad.mit.edu	37	chr5	156635937	156635937	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggtccattgagctctcccGaatcaaatgtgttgagattg	12	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:156635937G>A	ENST00000422843.3	+	2	328	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	59	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.R59Q(1)		breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGCTCTCCCGAATCAAATGT	0.458			T	SYK	peripheral T-cell lymphoma								7	18					0	0	1	0	0	A	156635937	G	A	156635937	3	1	48	1	0	0	0	0	1	0	0	0	7952	1058	37	1	182	1	ITK	5	156635937	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42915	156635937	24279323	1582	5976										
CYFIP2	26999	broad.mit.edu	37	chr5	156757772	156757772	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgttggataaacgttttCgagctgagtgtaagaattat	10	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:156757772C>T	ENST00000347377.6	+	20	2610	c.2179C>T	c.(2179-2181)Cga>Tga	p.R727*	CYFIP2_ENST00000541131.1_Nonsense_Mutation_p.R652*|CYFIP2_ENST00000522463.1_Nonsense_Mutation_p.R531*|CYFIP2_ENST00000521420.1_Nonsense_Mutation_p.R701*|CYFIP2_ENST00000318218.6_Nonsense_Mutation_p.R752*|CYFIP2_ENST00000442283.2_Nonsense_Mutation_p.R12*|CYFIP2_ENST00000435847.2_Nonsense_Mutation_p.R426*|CYFIP2_ENST00000377576.3_Nonsense_Mutation_p.R727*	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	752					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TAAACGTTTTCGAGCTGAGTG	0.448													10	27					0	0	1	0	0	T	156757772	C	T	156757772	4	4	48	1	0	0	0	0	0	1	0	0	4161	876	31	1	2253	1	CYFIP2	5	156757772	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	121835	156757772	24157488	1583	5977										
CYFIP2	26999	broad.mit.edu	37	chr5	156816422	156816422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatccctgtgggaaccaacGagttcacagctgagtgagta	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:156816422G>A	ENST00000347377.6	+	29	3864	c.3433G>A	c.(3433-3435)Gag>Aag	p.E1145K	CYFIP2_ENST00000522463.1_Missense_Mutation_p.E949K|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000541131.1_Missense_Mutation_p.E1070K|CYFIP2_ENST00000435847.2_Missense_Mutation_p.E844K|CYFIP2_ENST00000318218.6_Missense_Mutation_p.E1170K|CYFIP2_ENST00000377576.3_Missense_Mutation_p.E1145K|CYFIP2_ENST00000521420.1_Missense_Mutation_p.E1119K	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1170					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGAACCAACGAGTTCACAGC	0.597													15	21					0	0	1	0	0	A	156816422	G	A	156816422	3	1	48	1	0	0	0	0	1	0	0	0	4161	1059	37	1	3543	1	CYFIP2	5	156816422	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58650	156816422	24098838	1584	5978										
SOX30	11063	broad.mit.edu	37	chr5	157053528	157053528	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatgactgttatagtaagaAgttccattcatgttctcaca	6	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:157053528A>G	ENST00000265007.6	-	5	2423	c.2082T>C	c.(2080-2082)acT>acC	p.T694T	SOX30_ENST00000311371.5_3'UTR|SOX30_ENST00000519442.1_Silent_p.T389T	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	694					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TATAGTAAGAAGTTCCATTCA	0.408													11	25					0	0	1	0	0	G	157053528	A	G	157053528	2	3	48	1	0	0	0	0	0	0	0	1	15005	59	3	4		4	SOX30	5	157053528	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	237106	157053528	23861732	1585	5979										
LSM11	134353	broad.mit.edu	37	chr5	157178487	157178487	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccgcactttcaagggacttCggggcgtctgtacaggcttc	12	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:157178487C>T	ENST00000286307.5	+	2	594	c.538C>T	c.(538-540)Cgg>Tgg	p.R180W		NM_173491.2	NP_775762.1	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	180	SM 1.				histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding	p.R180W(1)		breast(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	7	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAAGGGACTTCGGGGCGTCTG	0.498													24	57					0	0	1	0	0	T	157178487	C	T	157178487	3	4	48	1	0	0	0	0	1	0	0	0	9096	875	31	1	544	1	LSM11	5	157178487	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	124959	157178487	23736773	1586	5980										
CLINT1	9685	broad.mit.edu	37	chr5	157218887	157218887	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtgagccactaacaagttCtaccgctggctgtgaggcac	11	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:157218887C>A	ENST00000523094.1	-	10	1355	c.1150G>T	c.(1150-1152)Gaa>Taa	p.E384*	CLINT1_ENST00000530742.1_Nonsense_Mutation_p.E384*|CLINT1_ENST00000523908.1_Nonsense_Mutation_p.E402*|CLINT1_ENST00000411809.2_Nonsense_Mutation_p.E402*|CLINT1_ENST00000296951.5_Nonsense_Mutation_p.E384*	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	402					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTAACAAGTTCTACCGCTGGC	0.542													28	49					1.42536e-11	1.77514e-11	1	1	0	A	157218887	C	A	157218887	4	1	48	1	0	0	0	0	0	1	0	0	3554	922	32	2	685	2	CLINT1	5	157218887	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	40400	157218887	23696373	1587	5981										
RNF145	153830	broad.mit.edu	37	chr5	158603743	158603743	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtaaaaatcatagcaaatTtattgatgataacaattgtc	5	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:158603743T>G	ENST00000424310.2	-	5	877	c.518A>C	c.(517-519)aAa>aCa	p.K173T	RNF145_ENST00000519865.1_Missense_Mutation_p.K173T|RNF145_ENST00000518802.1_Missense_Mutation_p.K203T|RNF145_ENST00000520638.1_Missense_Mutation_p.K187T|RNF145_ENST00000521606.2_Missense_Mutation_p.K190T|RNF145_ENST00000274542.2_Missense_Mutation_p.K201T	NM_001199383.1	NP_001186312.1	Q96MT1	RN145_HUMAN	ring finger protein 145	173						integral to membrane	zinc ion binding			endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CATAGCAAATTTATTGATGAT	0.373													16	23					0	0	1	0	0	G	158603743	T	G	158603743	3	3	48	1	0	0	0	0	1	0	0	0	13498	1841	64	4	1501	4	RNF145	5	158603743	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1384856	158603743	22311517	1588	5982										
ADRA1B	147	broad.mit.edu	37	chr5	159398918	159398918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaccctgaagccccccgacGccgtgttcaaggtggtgttc	11	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:159398918G>A	ENST00000306675.3	+	2	1105	c.982G>A	c.(982-984)Gcc>Acc	p.A328T		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	328					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	GCCCCCCGACGCCGTGTTCAA	0.602													20	62					0	0	1	0	0	A	159398918	G	A	159398918	3	1	48	1	0	0	0	0	1	0	0	0	334	1087	38	1	988	1	ADRA1B	5	159398918	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	795175	159398918	21516342	1589	5983										
SLU7	10569	broad.mit.edu	37	chr5	159835009	159835009	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcctgcattggcataagGattctctctcattgctctag	7	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:159835009G>A	ENST00000297151.4	-	9	1273	c.886C>T	c.(886-888)Cct>Tct	p.P296S		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	296					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGGCATAAGGATTCTCTCTC	0.308													29	52					0	0	1	0	0	A	159835009	G	A	159835009	3	1	48	1	0	0	0	0	1	0	0	0	14808	1174	41	3	906	3	SLU7	5	159835009	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	436091	159835009	21080251	1590	5984										
GABRB2	0	broad.mit.edu	37	chr5	160721219	160721219	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattttcagttgggaggcgcGtctcctcaggcgacttttct	12	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:160721219G>A	ENST00000274547.2	-	11	1625	c.1408C>T	c.(1408-1410)Cgc>Tgc	p.R470C	GABRB2_ENST00000517547.1_Missense_Mutation_p.R272C|GABRB2_ENST00000353437.6_Missense_Mutation_p.R432C|GABRB2_ENST00000520240.1_Missense_Mutation_p.R432C|GABRB2_ENST00000393959.1_Missense_Mutation_p.R470C|GABRB2_ENST00000517901.1_Missense_Mutation_p.R369C	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	470					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity	p.R432C(2)|p.R470C(2)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGGGAGGCGCGTCTCCTCAGG	0.507													27	52					0	0	1	0	0	A	160721219	G	A	160721219	3	1	48	1	0	0	0	0	1	0	0	0	6201	1145	40	1	134	1	GABRB2	5	160721219	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	886210	160721219	20194041	1591	5985										
GABRB2	0	broad.mit.edu	37	chr5	160753387	160753387	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatctaaccgtatacagagaGaaatcgtaattggtagtccg	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:160753387G>T	ENST00000274547.2	-	10	1396	c.1179C>A	c.(1177-1179)ttC>ttA	p.F393L	GABRB2_ENST00000517547.1_Intron|GABRB2_ENST00000353437.6_Intron|GABRB2_ENST00000520240.1_Intron|GABRB2_ENST00000393959.1_Missense_Mutation_p.F393L|GABRB2_ENST00000517901.1_Intron	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	393					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TATACAGAGAGAAATCGTaat	0.373													7	31					0.0381472	0.0387537	1	1	0	T	160753387	G	T	160753387	3	4	48	1	0	0	0	0	1	0	0	0	6201	933	33	2	367	2	GABRB2	5	160753387	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	32168	160753387	20161873	1592	5986										
GABRB2	0	broad.mit.edu	37	chr5	160761811	160761811	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaatccagaaggagacccaGgagaggatggtaatcaggat	13	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:160761811G>A	ENST00000274547.2	-	8	997	c.780C>T	c.(778-780)tcC>tcT	p.S260S	GABRB2_ENST00000517547.1_Silent_p.S100S|GABRB2_ENST00000353437.6_Silent_p.S260S|GABRB2_ENST00000520240.1_Silent_p.S260S|GABRB2_ENST00000393959.1_Silent_p.S260S|GABRB2_ENST00000517901.1_Silent_p.S197S	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	260					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGGAGACCCAGGAGAGGATGG	0.433													18	39					0	0	1	0	0	A	160761811	G	A	160761811	2	1	48	1	0	0	0	0	0	0	0	1	6201	987	35	3		3	GABRB2	5	160761811	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8424	160761811	20153449	1593	5987										
GABRG2	0	broad.mit.edu	37	chr5	161495013	161495013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaaaaaaagcgatgagttCgccaaatatatggagcacag	9	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:161495013C>T	ENST00000356592.3	+	1	468	c.8C>T	c.(7-9)tCg>tTg	p.S3L	GABRG2_ENST00000414552.2_Missense_Mutation_p.S3L|GABRG2_ENST00000361925.4_Missense_Mutation_p.S3L	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	3					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GCGATGAGTTCGCCAAATATA	0.453													16	35					0	0	1	0	0	T	161495013	C	T	161495013	3	4	48	1	0	0	0	0	1	0	0	0	6206	893	31	1	10	1	GABRG2	5	161495013	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	733202	161495013	19420247	1594	5988										
NUDCD2	134492	broad.mit.edu	37	chr5	162883965	162883965	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatctctctaatgtaagcttTctctgcatttggtcttgcac	6	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:162883965T>C	ENST00000302764.4	-	3	449	c.360A>G	c.(358-360)agA>agG	p.R120R	NUDCD2_ENST00000517501.1_Silent_p.R95R	NM_145266.4	NP_660309.1	Q8WVJ2	NUDC2_HUMAN	NudC domain containing 2	120						intracellular				large_intestine(1)|prostate(1)	2	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)		ATGTAAGCTTTCTCTGCATTT	0.323													14	50					0	0	1	0	0	C	162883965	T	C	162883965	2	2	48	1	0	0	0	0	0	0	0	1	10770	1780	62	4		4	NUDCD2	5	162883965	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1388952	162883965	18031295	1595	5989										
HMMR	3161	broad.mit.edu	37	chr5	162900240	162900240	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaaacagaaaaactcttgGaatacatcgaagaaattagg	8	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:162900240G>T	ENST00000416990.2	+	8	858	c.361G>T	c.(361-363)Gaa>Taa	p.E121*	HMMR_ENST00000432118.2_Nonsense_Mutation_p.E149*|HMMR_ENST00000358715.3_Nonsense_Mutation_p.E235*|HMMR_ENST00000393915.4_Nonsense_Mutation_p.E236*|HMMR_ENST00000353866.3_Nonsense_Mutation_p.E220*			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	235						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		AAAACTCTTGGAATACATCGA	0.264													6	15					0.00116845	0.00122532	1	1	0	T	162900240	G	T	162900240	4	4	48	1	0	0	0	0	0	1	0	0	7282	1175	41	2	736	2	HMMR	5	162900240	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16275	162900240	18015020	1596	5990										
HMMR	3161	broad.mit.edu	37	chr5	162902573	162902573	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacactggatgagcttgataAattacagcaaaaggaggaac	10	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:162902573A>C	ENST00000416990.2	+	11	1315	c.818A>C	c.(817-819)aAa>aCa	p.K273T	HMMR_ENST00000432118.2_Missense_Mutation_p.K301T|HMMR_ENST00000358715.3_Missense_Mutation_p.K387T|HMMR_ENST00000393915.4_Missense_Mutation_p.K388T|HMMR_ENST00000353866.3_Missense_Mutation_p.K372T			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	387						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		GAGCTTGATAAATTACAGCAA	0.383													14	47					0	0	1	0	0	C	162902573	A	C	162902573	3	2	48	1	0	0	0	0	1	0	0	0	7282	14	1	4	1205	4	HMMR	5	162902573	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2333	162902573	18012687	1597	5991										
MAT2B	27430	broad.mit.edu	37	chr5	162945299	162945299	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggccaacgaacaccatttcGaattggaatcaaagaatcac	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:162945299G>A	ENST00000280969.5	+	7	1183	c.902G>A	c.(901-903)cGa>cAa	p.R301Q	MAT2B_ENST00000518731.1_3'UTR|MAT2B_ENST00000521838.1_3'UTR|MAT2B_ENST00000518095.1_3'UTR|MAT2B_ENST00000321757.6_Missense_Mutation_p.R312Q	NM_182796.1	NP_877725.1	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta	312					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding	p.R301Q(1)		endometrium(3)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	14	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	ACACCATTTCGAATTGGAATC	0.423													13	21					0	0	1	0	0	A	162945299	G	A	162945299	3	1	48	1	0	0	0	0	1	0	0	0	9380	1058	37	1	995	1	MAT2B	5	162945299	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42726	162945299	17969961	1598	5992										
SLIT3	6586	broad.mit.edu	37	chr5	168180967	168180967	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacgctggctgctccatcGaaagctccctctcgcacctc	8	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:168180967G>A	ENST00000519560.1	-	17	2150	c.1731C>T	c.(1729-1731)ttC>ttT	p.F577F	SLIT3_ENST00000404867.3_Silent_p.F577F|SLIT3_ENST00000332966.8_Silent_p.F577F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	577					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGCTCCATCGAAAGCTCCCT	0.532													6	14					0	0	1	0	0	A	168180967	G	A	168180967	2	1	48	1	0	0	0	0	0	0	0	1	14794	1049	37	1		1	SLIT3	5	168180967	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5235668	168180967	12734293	1599	5993										
FBXW11	23291	broad.mit.edu	37	chr5	171326969	171326969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggatcagtgcgtaccattCgttcaatcagcttcttccaa	9	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:171326969C>T	ENST00000296933.6	-	4	840	c.470G>A	c.(469-471)cGa>cAa	p.R157Q	FBXW11_ENST00000265094.5_Missense_Mutation_p.R170Q|FBXW11_ENST00000425623.2_Missense_Mutation_p.R138Q|FBXW11_ENST00000393802.2_Missense_Mutation_p.R136Q|FBXW11_ENST00000522891.1_5'UTR	NM_033644.2|NM_033645.2	NP_387448.2|NP_387449.2	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11	170	F-box.				cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.R170Q(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	21	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCGTACCATTCGTTCAATCAG	0.448													73	108					0	0	1	0	0	T	171326969	C	T	171326969	3	4	48	1	0	0	0	0	1	0	0	0	5796	884	31	1	1155	1	FBXW11	5	171326969	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3146002	171326969	9588291	1600	5994										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171766016	171766016	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctcctgggaggaagcttCggctgaaggccacgtcttgg	14	12	2	1	rs144659619	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:171766016C>T	ENST00000311601.5	-	13	2263	c.2093G>A	c.(2092-2094)cGa>cAa	p.R698Q	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	698					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGGAAGCTTCGGCTGAAGGC	0.632													22	45					0	0	1	0	0	T	171766016	C	T	171766016	3	4	48	1	0	0	0	0	1	0	0	0	14311	884	31	1	646	1	SH3PXD2B	5	171766016	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	439047	171766016	9149244	1601	5995										
HIGD2A	192286	broad.mit.edu	37	chr5	175815966	175815966	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacccgcgagaacccggtggTacccataggtaagtgggtgc	15	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:175815966T>C	ENST00000274787.2	+	1	219	c.146T>C	c.(145-147)gTa>gCa	p.V49A	NOP16_ENST00000389158.5_5'UTR	NM_138820.2	NP_620175.1	Q9BW72	HIG2A_HUMAN	HIG1 hypoxia inducible domain family, member 2A	49	HIG1.					integral to membrane				large_intestine(1)	1	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		AACCCGGTGGTACCCATAGGT	0.562													26	58					0	0	1	0	0	C	175815966	T	C	175815966	3	2	48	1	0	0	0	0	1	0	0	0	7149	1638	57	4	148	4	HIGD2A	5	175815966	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4049950	175815966	5099294	1602	5996										
CLTB	1212	broad.mit.edu	37	chr5	175824668	175824668	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctggttccactcctccaggTccttcttggccttctcccgc	8	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:175824668T>C	ENST00000310418.4	-	4	609	c.404A>G	c.(403-405)gAc>gGc	p.D135G	CLTB_ENST00000345807.2_Missense_Mutation_p.D135G	NM_007097.3	NP_009028.1	P09497	CLCB_HUMAN	clathrin, light chain B	135	Involved in binding clathrin heavy chain.				intracellular protein transport|vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle	protein binding|structural molecule activity			lung(1)	1	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.098)		CTCCTCCAGGTCCTTCTTGGC	0.552													6	78					0	0	1	0	0	C	175824668	T	C	175824668	3	2	48	1	0	0	0	0	1	0	0	0	3588	1667	58	4	297	4	CLTB	5	175824668	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8702	175824668	5090592	1603	5997										
FAF2	23197	broad.mit.edu	37	chr5	175921084	175921084	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggactctgatgagttttgtCggtaagtggattgattattt	12	3	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:175921084C>T	ENST00000261942.6	+	6	621	c.569_splice	c.e6+1	p.R190_splice		NM_014613.2	NP_055428.1	Q96CS3	FAF2_HUMAN	Fas associated factor family member 2	190					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			breast(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TGAGTTTTGTCGGTAAGTGGA	0.403													17	38					0	0	1	0	0	T	175921084	C	T	175921084	5	4	48	1	0	0	0	0	0	0	1	0	5401	898	31	1	590	1	FAF2	5	175921084	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	96416	175921084	4994176	1604	5998										
CDHR2	54825	broad.mit.edu	37	chr5	176002378	176002378	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagcctgaccttgacccccAgtttgtcagggagttttact	9	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176002378A>G	ENST00000510636.1	+	9	993	c.719A>G	c.(718-720)cAg>cGg	p.Q240R	CDHR2_ENST00000506348.1_Missense_Mutation_p.Q240R|CDHR2_ENST00000261944.5_Missense_Mutation_p.Q240R	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	240	Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CTTGACCCCCAGTTTGTCAGG	0.617													26	46					0	0	1	0	0	G	176002378	A	G	176002378	3	3	48	1	0	0	0	0	1	0	0	0	3141	188	7	4	749	4	CDHR2	5	176002378	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	81294	176002378	4912882	1605	5999										
UNC5A	90249	broad.mit.edu	37	chr5	176304275	176304275	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgctgcacaagccggaagaCgtgaggtgtggccgcgggcc	17	12	0	2	rs150349541		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176304275C>T	ENST00000329542.4	+	9	1735	c.1461C>T	c.(1459-1461)gaC>gaT	p.D487D	UNC5A_ENST00000261961.3_Silent_p.D447D	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	487	ZU5.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCCGGAAGACGTGAGGTGTG	0.652													29	36					0	0	1	0	0	T	176304275	C	T	176304275	2	4	48	1	0	0	0	0	0	0	0	1	17050	535	19	1		1	UNC5A	5	176304275	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	301897	176304275	4610985	1606	6000										
NSD1	64324	broad.mit.edu	37	chr5	176639179	176639179	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccagtttgacaccacaggCtgagctccctgaaccaggta	9	14	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176639179C>T	ENST00000439151.2	+	5	3824	c.3779C>T	c.(3778-3780)gCt>gTt	p.A1260V	NSD1_ENST00000354179.4_Missense_Mutation_p.A991V|NSD1_ENST00000361032.4_Missense_Mutation_p.A1157V|NSD1_ENST00000347982.4_Missense_Mutation_p.A991V	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1260					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACACCACAGGCTGAGCTCCCT	0.413			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			9	23					0	0	1	0	0	T	176639179	C	T	176639179	3	4	48	1	0	0	0	0	1	0	0	0	10716	797	28	3	3793	3	NSD1	5	176639179	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	334904	176639179	4276081	1607	6001										
NSD1	64324	broad.mit.edu	37	chr5	176665324	176665324	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggacgagaattctttgatTtcaaccaaagaagagcctcc	9	9	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176665324T>G	ENST00000439151.2	+	7	4053	c.4008T>G	c.(4006-4008)atT>atG	p.I1336M	NSD1_ENST00000354179.4_Missense_Mutation_p.I1067M|NSD1_ENST00000361032.4_Missense_Mutation_p.I1233M|NSD1_ENST00000347982.4_Missense_Mutation_p.I1067M	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1336					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATTCTTTGATTTCAACCAAAG	0.502			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			21	85					0	0	1	0	0	G	176665324	T	G	176665324	3	3	48	1	0	0	0	0	1	0	0	0	10716	1829	64	4	4030	4	NSD1	5	176665324	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	26145	176665324	4249936	1608	6002										
NSD1	64324	broad.mit.edu	37	chr5	176675273	176675273	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggatgcctgcctctaaaaAaatgcagggtgaacgcggtg	14	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176675273A>C	ENST00000439151.2	+	11	4634	c.4589A>C	c.(4588-4590)aAa>aCa	p.K1530T	NSD1_ENST00000354179.4_Missense_Mutation_p.K1261T|NSD1_ENST00000361032.4_Missense_Mutation_p.K1427T|NSD1_ENST00000347982.4_Missense_Mutation_p.K1261T	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1530					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCCTCTAAAAAAATGCAGGGT	0.498			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			13	27					0	0	1	0	0	C	176675273	A	C	176675273	3	2	48	1	0	0	0	0	1	0	0	0	10716	14	1	4	4627	4	NSD1	5	176675273	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	9949	176675273	4239987	1609	6003										
RGS14	10636	broad.mit.edu	37	chr5	176798548	176798548	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagttctctggtgaaggtgCccagtagtgccactggaaag	13	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176798548C>T	ENST00000408923.3	+	14	1644	c.1456C>T	c.(1456-1458)Ccc>Tcc	p.P486S	RGS14_ENST00000506944.1_3'UTR	NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	486					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGTGAAGGTGCCCAGTAGTGC	0.577													74	122					0	0	1	0	0	T	176798548	C	T	176798548	3	4	48	1	0	0	0	0	1	0	0	0	13346	739	26	3	1510	3	RGS14	5	176798548	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	123275	176798548	4116712	1610	6004										
FAM193B	54540	broad.mit.edu	37	chr5	176951478	176951478	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctggctgcttggggccagcGacctggcccttggcactggg	16	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:176951478G>A	ENST00000329540.5	-	9	3711	c.882C>T	c.(880-882)gtC>gtT	p.V294V	FAM193B_ENST00000514747.1_Silent_p.V668V|FAM193B_ENST00000443375.2_Silent_p.V635V			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	344										kidney(1)|large_intestine(3)	4						TGGGGCCAGCGACCTGGCCCT	0.682													9	20					0	0	1	0	0	A	176951478	G	A	176951478	2	1	48	1	0	0	0	0	0	0	0	1	5556	1045	37	1		1	FAM193B	5	176951478	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	152930	176951478	3963782	1611	6005										
HNRNPAB	3182	broad.mit.edu	37	chr5	177634126	177634126	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaattgccaatggatccaaAgttgaacaaaagacgaggtt	10	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:177634126A>C	ENST00000358344.3	+	5	826	c.569A>C	c.(568-570)aAg>aCg	p.K190T	HNRNPAB_ENST00000504898.1_Missense_Mutation_p.K190T|HNRNPAB_ENST00000515193.1_Missense_Mutation_p.K190T|HNRNPAB_ENST00000355836.5_Missense_Mutation_p.K190T|HNRNPAB_ENST00000514633.1_Missense_Mutation_p.K190T|HNRNPAB_ENST00000506259.1_Missense_Mutation_p.K190T|HNRNPAB_ENST00000506339.1_Missense_Mutation_p.K190T	NM_031266.2	NP_112556.2	Q99729	ROAA_HUMAN	heterogeneous nuclear ribonucleoprotein A/B	190	RRM 2.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			large_intestine(4)|prostate(1)|urinary_tract(1)	6						ATGGATCCAAAGTTGAACAAA	0.443													33	58					0	0	1	0	0	C	177634126	A	C	177634126	3	2	48	1	0	0	0	0	1	0	0	0	7301	72	3	4	583	4	HNRNPAB	5	177634126	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	682648	177634126	3281134	1612	6006										
ZNF354B	117608	broad.mit.edu	37	chr5	178309997	178309997	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaacagagatttgctaaaGaaaaaactccatcaaaatgt	6	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178309997G>T	ENST00000322434.3	+	5	770	c.544G>T	c.(544-546)Gaa>Taa	p.E182*		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATTTGCTAAAGAAAAAACTCC	0.299													9	22					0.000442599	0.00046913	1	1	0	T	178309997	G	T	178309997	4	4	48	1	0	0	0	0	0	1	0	0	17921	943	33	2	558	2	ZNF354B	5	178309997	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	675871	178309997	2605263	1613	6007			1	9		5	5	1166	N	G_A	3.115251e-05
ZNF354B	117608	broad.mit.edu	37	chr5	178310254	178310254	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagaactcatacaggagaGaaaccctatatatgtaaaga	7	7	1	3	rs147300334	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178310254G>T	ENST00000322434.3	+	5	1027	c.801G>T	c.(799-801)gaG>gaT	p.E267D		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATACAGGAGAGAAACCCTATA	0.353													29	46					1.38267e-23	1.93402e-23	1	1	0	T	178310254	G	T	178310254	3	4	48	1	0	0	0	0	1	0	0	0	17921	933	33	2	815	2	ZNF354B	5	178310254	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	257	178310254	2605006	1614	6008			1	9		5	5	1166	N	G_A	3.115251e-05
ZNF354B	117608	broad.mit.edu	37	chr5	178310741	178310741	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacgacttaatagacaccgaAtaattcatactggagagaaa	7	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178310741A>G	ENST00000322434.3	+	5	1514	c.1288A>G	c.(1288-1290)Ata>Gta	p.I430V		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGACACCGAATAATTCATAC	0.358													18	46					0	0	1	0	0	G	178310741	A	G	178310741	3	3	48	1	0	0	0	0	1	0	0	0	17921	101	4	4	1302	4	ZNF354B	5	178310741	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	487	178310741	2604519	1615	6009			1	9		5	5	1166	N	G_A	3.115251e-05
ZNF354B	117608	broad.mit.edu	37	chr5	178310994	178310994	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgcttagtaatcaccagaGaattcatactggagagaaac	8	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178310994G>T	ENST00000322434.3	+	5	1767	c.1541G>T	c.(1540-1542)aGa>aTa	p.R514I	ZNF354B_ENST00000522714.1_3'UTR	NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AATCACCAGAGAATTCATACT	0.393													25	51					5.35356e-11	6.62625e-11	1	1	0	T	178310994	G	T	178310994	3	4	48	1	0	0	0	0	1	0	0	0	17921	942	33	2	1555	2	ZNF354B	5	178310994	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	253	178310994	2604266	1616	6010			1	9		5	5	1166	N	G_A	3.115251e-05
ZNF354B	117608	broad.mit.edu	37	chr5	178311162	178311162	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcacttattgcacatcaaaGaattcatactggagagaaac	6	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178311162G>T	ENST00000322434.3	+	5	1935	c.1709G>T	c.(1708-1710)aGa>aTa	p.R570I	ZNF354B_ENST00000522714.1_3'UTR	NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCACATCAAAGAATTCATACT	0.343													4	42					0.00024832	0.000265255	1	1	0	T	178311162	G	T	178311162	3	4	48	1	0	0	0	0	1	0	0	0	17921	942	33	2	1723	2	ZNF354B	5	178311162	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	168	178311162	2604098	1617	6011			1	9		5	5	1166	N	G_A	3.115251e-05
GRM6	2916	broad.mit.edu	37	chr5	178416330	178416330	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcagtttgcagttaaaattCtcttcccagaactcggcgaa	8	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178416330C>A	ENST00000231188.5	-	5	1267	c.1089G>T	c.(1087-1089)gaG>gaT	p.E363D	GRM6_ENST00000517717.1_Missense_Mutation_p.E363D|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	363					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGTTAAAATTCTCTTCCCAGA	0.547													25	47					1.10923e-09	1.34134e-09	1	1	0	A	178416330	C	A	178416330	3	1	48	1	0	0	0	0	1	0	0	0	6841	912	32	2	1568	2	GRM6	5	178416330	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	105168	178416330	2498930	1618	6012										
GRM6	2916	broad.mit.edu	37	chr5	178418532	178418532	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctttggttccctgggaatCttgatagactgggcaataca	12	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178418532C>A	ENST00000231188.5	-	3	928	c.750G>T	c.(748-750)aaG>aaT	p.K250N	GRM6_ENST00000517717.1_Missense_Mutation_p.K250N	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	250					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CCCTGGGAATCTTGATAGACT	0.602													5	248					1	1	1	1	0	A	178418532	C	A	178418532	3	1	48	1	0	0	0	0	1	0	0	0	6841	912	32	2	1915	2	GRM6	5	178418532	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2202	178418532	2496728	1619	6013										
ADAMTS2	9509	broad.mit.edu	37	chr5	178559847	178559847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgttgtcccctccgcacaCgccacacttgtcttcctgct	7	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:178559847C>T	ENST00000251582.7	-	14	2241	c.2140G>A	c.(2140-2142)Gtg>Atg	p.V714M		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	714	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCTCCGCACACGCCACACTTG	0.602													19	24					0	0	1	0	0	T	178559847	C	T	178559847	3	4	48	1	0	0	0	0	1	0	0	0	264	536	19	1	1531	1	ADAMTS2	5	178559847	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	141315	178559847	2355413	1620	6014										
RNF130	55819	broad.mit.edu	37	chr5	179394008	179394008	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcagtacatggcaaattCggctgcaaaatatttccagg	8	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:179394008C>T	ENST00000522208.2	-	7	966	c.948G>A	c.(946-948)ccG>ccA	p.P316P	RNF130_ENST00000521389.1_Silent_p.P316P|RNF130_ENST00000261947.4_Silent_p.P316P			Q86XS8	GOLI_HUMAN	ring finger protein 130	316					apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	17	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGGCAAATTCGGCTGCAAAA	0.423													24	47					0	0	1	0	0	T	179394008	C	T	179394008	2	4	48	1	0	0	0	0	0	0	0	1	13489	871	31	1		1	RNF130	5	179394008	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	834161	179394008	1521252	1621	6015										
MAPK9	5601	broad.mit.edu	37	chr5	179676006	179676006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccatacccaggatgacttCgggcgcccggtagtaccgtg	13	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:179676006C>T	ENST00000452135.2	-	6	881	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K	MAPK9_ENST00000524170.1_5'UTR|MAPK9_ENST00000347470.4_Missense_Mutation_p.E195K|MAPK9_ENST00000397072.3_3'UTR|MAPK9_ENST00000393360.3_Missense_Mutation_p.E195K|MAPK9_ENST00000539014.1_Missense_Mutation_p.E195K|MAPK9_ENST00000343111.6_Missense_Mutation_p.E195K|MAPK9_ENST00000455781.1_Missense_Mutation_p.E195K|MAPK9_ENST00000425491.2_Missense_Mutation_p.E195K			P45984	MK09_HUMAN	mitogen-activated protein kinase 9	195	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGATGACTTCGGGCGCCCGG	0.552													27	367					0	0	1	0	0	T	179676006	C	T	179676006	3	4	48	1	0	0	0	0	1	0	0	0	9336	893	31	1	841	1	MAPK9	5	179676006	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	281998	179676006	1239254	1622	6016										
BTNL8	79908	broad.mit.edu	37	chr5	180374609	180374609	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgttggactgaagattttCttctccaaattccagtgtaa	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:180374609C>A	ENST00000231229.4	+	4	1005	c.771C>A	c.(769-771)ttC>ttA	p.F257L	BTNL8_ENST00000400707.3_Missense_Mutation_p.F132L|BTNL8_ENST00000511704.1_Missense_Mutation_p.F141L|BTNL8_ENST00000508408.1_Missense_Mutation_p.F257L|BTNL8_ENST00000340184.4_Missense_Mutation_p.F257L|BTNL8_ENST00000533815.2_Missense_Mutation_p.F73L|BTNL8_ENST00000505126.1_Missense_Mutation_p.F50L	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	257						integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAAGATTTTCTTCTCCAAAT	0.488													11	238					7.03913e-09	8.36985e-09	1	1	0	A	180374609	C	A	180374609	3	1	48	1	0	0	0	0	1	0	0	0	1570	912	32	2	811	2	BTNL8	5	180374609	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	698603	180374609	540651	1623	6017										
TRIM41	90933	broad.mit.edu	37	chr5	180651723	180651723	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctcttctgcgaggtagacGaagaggccatctgtgtggtg	15	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr5:180651723G>A	ENST00000315073.5	+	1	1434	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	CTC-338M12.7_ENST00000499096.2_RNA|TRIM41_ENST00000351937.5_Missense_Mutation_p.E242K	NM_033549.4	NP_291027.3	Q8WV44	TRI41_HUMAN	tripartite motif containing 41	242						cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding	p.E242*(1)		NS(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|prostate(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGAGGTAGACGAAGAGGCCAT	0.587													26	54					0	0	1	0	0	A	180651723	G	A	180651723	3	1	48	1	0	0	0	0	1	0	0	0	16576	1059	37	1	726	1	TRIM41	5	180651723	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	277114	180651723	263537	1624	6018										
RREB1	6239	broad.mit.edu	37	chr6	7240690	7240690	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcagaaacccttcccttgTcaaaaatgcgatgccttctt	7	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:7240690T>G	ENST00000379938.2	+	11	4365	c.3828T>G	c.(3826-3828)tgT>tgG	p.C1276W	RREB1_ENST00000349384.6_Intron|RREB1_ENST00000379933.3_Intron|RREB1_ENST00000334984.6_Missense_Mutation_p.C1276W	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1272					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCTTCCCTTGTCAAAAATGCG	0.413													7	87					0	0	1	0	0	G	7240690	T	G	7240690	3	3	48	1	0	0	0	0	1	0	0	0	13730	1673	58	4	3858	4	RREB1	6	7240690	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08		7240690	163874377	1625	6019										
CAGE1	285782	broad.mit.edu	37	chr6	7373600	7373600	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattcctcctgtaaagacaaGaactcttgttcttgggcctc	7	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:7373600G>T	ENST00000502583.1	-	5	2016	c.1452C>A	c.(1450-1452)ttC>ttA	p.F484L	CAGE1_ENST00000512086.1_Missense_Mutation_p.F484L|CAGE1_ENST00000379918.4_Missense_Mutation_p.F484L|CAGE1_ENST00000338150.4_Missense_Mutation_p.F484L|CAGE1_ENST00000296742.7_Missense_Mutation_p.F348L	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	484										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					GTAAAGACAAGAACTCTTGTT	0.398													12	11					0.0135373	0.0139058	1	1	0	T	7373600	G	T	7373600	3	4	48	1	0	0	0	0	1	0	0	0	2590	933	33	2	1213	2	CAGE1	6	7373600	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	132910	7373600	163741467	1626	6020										
EEF1E1	9521	broad.mit.edu	37	chr6	8090502	8090502	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagactttatcttcaagatAtgaattaagatcctagaaaa	6	5	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:8090502A>G	ENST00000379715.5	-	3	357	c.301T>C	c.(301-303)Tat>Cat	p.Y101H	EEF1E1_ENST00000507463.1_Missense_Mutation_p.Y101H|EEF1E1_ENST00000429723.2_Missense_Mutation_p.Y101H|EEF1E1-MUTED_ENST00000397456.2_Missense_Mutation_p.Y101H	NM_004280.4	NP_004271.1	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1 epsilon 1	101	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus				endometrium(1)|prostate(1)	2	Ovarian(93;0.0398)					TCTTCAAGATATGAATTAAGA	0.249													12	14					0	0	1	0	0	G	8090502	A	G	8090502	3	3	48	1	0	0	0	0	1	0	0	0	4953	449	16	4	271	4	EEF1E1	6	8090502	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	716902	8090502	163024565	1627	6021										
GCNT2	2651	broad.mit.edu	37	chr6	10556716	10556716	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctagtgtaattatttttatCgtcttctctgtgttcaattt	5	6	4	0	rs55665031		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:10556716C>T	ENST00000316170.3	+	1	477	c.60C>T	c.(58-60)atC>atT	p.I20I	GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000397423.2_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	21						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TTATTTTTATCGTCTTCTCTG	0.388													11	55					0	0	1	0	0	T	10556716	C	T	10556716	2	4	48	1	0	0	0	0	0	0	0	1	6340	874	31	1		1	GCNT2	6	10556716	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2466214	10556716	160558351	1628	6022										
GCNT2	2651	broad.mit.edu	37	chr6	10556860	10556860	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacaaactaatgatccatgaGaagtcttcttgcaaggaata	7	7	2	2	rs56393118		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:10556860G>T	ENST00000316170.3	+	1	621	c.204G>T	c.(202-204)gaG>gaT	p.E68D	GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000397423.2_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	70						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGATCCATGAGAAGTCTTCTT	0.413													78	19					4.81439e-37	6.93071e-37	1	1	0	T	10556860	G	T	10556860	3	4	48	1	0	0	0	0	1	0	0	0	6340	933	33	2	1135	2	GCNT2	6	10556860	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	144	10556860	160558207	1629	6023										
MAK	4117	broad.mit.edu	37	chr6	10796399	10796399	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaacctgatcgattatatcCggcagaggcttaggctctac	9	11	1	2	rs145014649	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:10796399C>T	ENST00000313243.2	-	9	1357	c.975G>A	c.(973-975)ccG>ccA	p.P325P	MAK_ENST00000536370.1_3'UTR|MAK_ENST00000474039.1_Silent_p.P325P|MAK_ENST00000354489.2_Silent_p.P325P|SYCP2L_ENST00000543878.1_Intron|MAK_ENST00000538030.1_Silent_p.P325P|RP11-637O19.3_ENST00000480294.1_Intron			P20794	MAK_HUMAN	male germ cell-associated kinase	325	Glu/Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)	22	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				CGATTATATCCGGCAGAGGCT	0.483													28	62					0	0	1	0	0	T	10796399	C	T	10796399	2	4	48	1	0	0	0	0	0	0	0	1	9246	639	23	1		1	MAK	6	10796399	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	239539	10796399	160318668	1630	6024										
MAK	4117	broad.mit.edu	37	chr6	10819165	10819165	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcccaagaatagaactttCtcttcatcctaaaataaatt	2	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:10819165C>A	ENST00000313243.2	-	3	492	c.110G>T	c.(109-111)aGa>aTa	p.R37I	MAK_ENST00000536370.1_Missense_Mutation_p.R37I|MAK_ENST00000474039.1_Missense_Mutation_p.R37I|MAK_ENST00000354489.2_Missense_Mutation_p.R37I|SYCP2L_ENST00000543878.1_Intron|MAK_ENST00000538030.1_Missense_Mutation_p.R37I|RP11-637O19.3_ENST00000480294.1_Intron			P20794	MAK_HUMAN	male germ cell-associated kinase	37	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)	22	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				ATAGAACTTTCTCTTCATCCT	0.378													7	4					0.000157383	0.000169016	1	1	0	A	10819165	C	A	10819165	3	1	48	1	0	0	0	0	1	0	0	0	9246	913	32	2	1809	2	MAK	6	10819165	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22766	10819165	160295902	1631	6025										
PHACTR1	221692	broad.mit.edu	37	chr6	12933942	12933942	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgggcgtcctcttgggctcGaactgtgttccctggaaaac	12	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:12933942G>A	ENST00000379348.2	+	4	505	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	PHACTR1_ENST00000332995.7_Intron|PHACTR1_ENST00000379350.1_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	0						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TCTTGGGCTCGAACTGTGTTC	0.532													67	26					0	0	1	0	0	A	12933942	G	A	12933942	3	1	48	1	0	0	0	0	1	0	0	0	11856	1073	37	1		1	PHACTR1	6	12933942	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2114777	12933942	158181125	1632	6026										
TBC1D7	51256	broad.mit.edu	37	chr6	13327102	13327102	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttctcataatatactgaaCgaaagtttctctgagagtcc	6	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:13327102C>T	ENST00000607658.1	-	2	179	c.29G>A	c.(28-30)cGt>cAt	p.R10H	TBC1D7_ENST00000607532.1_5'UTR|TBC1D7_ENST00000379300.3_Missense_Mutation_p.R10H|TBC1D7_ENST00000356436.4_Missense_Mutation_p.R10H|TBC1D7_ENST00000343141.4_Missense_Mutation_p.R10H|TBC1D7_ENST00000379307.2_Missense_Mutation_p.R10H			Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7	10					positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			ATATACTGAACGAAAGTTTCT	0.383													26	7					0	0	1	0	0	T	13327102	C	T	13327102	3	4	48	1	0	0	0	0	1	0	0	0	15683	536	19	1	880	1	TBC1D7	6	13327102	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	393160	13327102	157787965	1633	6027										
NUP153	9972	broad.mit.edu	37	chr6	17629400	17629400	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttgggcagttcctctttCttttcttcctgtccaagatt	7	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:17629400C>T	ENST00000262077.2	-	18	3029	c.3030G>A	c.(3028-3030)aaG>aaA	p.K1010K	NUP153_ENST00000537253.1_Silent_p.K1041K	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	1010					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GTTCCTCTTTCTTTTCTTCCT	0.403													10	44					0	0	1	0	0	T	17629400	C	T	17629400	2	4	48	1	0	0	0	0	0	0	0	1	10802	912	32	3		3	NUP153	6	17629400	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4302298	17629400	153485667	1634	6028										
SLC17A3	10786	broad.mit.edu	37	chr6	25850809	25850809	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaatgggtagagatctgaGcatagctttgatgggaagag	14	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:25850809G>T	ENST00000397060.4	-	8	980	c.871C>A	c.(871-873)Ctc>Atc	p.L291I	SLC17A3_ENST00000361703.6_Missense_Mutation_p.L213I|SLC17A3_ENST00000360657.3_Missense_Mutation_p.L213I	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	213					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						AGAGATCTGAGCATAGCTTTG	0.428													37	14					7.04047e-22	9.7605e-22	1	1	0	T	25850809	G	T	25850809	3	4	48	1	0	0	0	0	1	0	0	0	14472	971	34	5	645	5	SLC17A3	6	25850809	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8221409	25850809	145264258	1635	6029										
HIST1H4D	8360	broad.mit.edu	37	chr6	26189200	26189200	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgcggcgagccaggcggcgGatagcgggcttggtgattcc	18	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:26189200G>A	ENST00000340756.2	-	1	104	c.105C>T	c.(103-105)atC>atT	p.I35I		NM_003539.3	NP_003530.1	P62805	H4_HUMAN	histone cluster 1, H4d	35					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)	8		all_hematologic(11;0.196)				CCAGGCGGCGGATAGCGGGCT	0.572													57	21					0	0	1	0	0	A	26189200	G	A	26189200	2	1	48	1	0	0	0	0	0	0	0	1	7208	1164	41	3		3	HIST1H4D	6	26189200	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	338391	26189200	144925867	1636	6030										
BTN3A2	11118	broad.mit.edu	37	chr6	26373245	26373245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaacagaaggaaataactgCtctgtccagtgagatagaaa	9	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:26373245C>T	ENST00000356386.2	+	6	1024	c.836C>T	c.(835-837)gCt>gTt	p.A279V	BTN3A2_ENST00000396934.3_Missense_Mutation_p.A256V|BTN3A2_ENST00000396948.1_Missense_Mutation_p.A279V|BTN3A2_ENST00000508906.2_Missense_Mutation_p.A237V|BTN3A2_ENST00000527422.1_Missense_Mutation_p.A279V|BTN3A2_ENST00000532994.1_3'UTR|BTN3A2_ENST00000377708.2_Missense_Mutation_p.A279V	NM_001197246.2|NM_001197247.1|NM_007047.3	NP_001184175.1|NP_001184176.1|NP_008978.2	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2	279						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)	10						GAAATAACTGCTCTGTCCAGT	0.512													28	58					0	0	1	0	0	T	26373245	C	T	26373245	3	4	48	1	0	0	0	0	1	0	0	0	1566	797	28	3	850	3	BTN3A2	6	26373245	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	184045	26373245	144741822	1637	6031										
BTN3A1	0	broad.mit.edu	37	chr6	26413752	26413752	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacttcctaagccccctaaGaaagtgggggtcttcctgga	10	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:26413752G>T	ENST00000289361.6	+	10	1742	c.1374G>T	c.(1372-1374)aaG>aaT	p.K458N	BTN3A1_ENST00000414912.2_Missense_Mutation_p.K406N	NM_001145008.1|NM_001145009.1|NM_007048.5	NP_001138480.1|NP_001138481.1|NP_008979.3	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1	458	B30.2/SPRY.				lipid metabolic process	integral to membrane				breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						AGCCCCCTAAGAAAGTGGGGG	0.478													71	39					3.28615e-30	4.69343e-30	1	1	0	T	26413752	G	T	26413752	3	4	48	1	0	0	0	0	1	0	0	0	1565	933	33	2	1576	2	BTN3A1	6	26413752	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40507	26413752	144701315	1638	6032										
BTN1A1	696	broad.mit.edu	37	chr6	26508797	26508797	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaggattcaaaatctgttCgactggaagattcacgtcag	10	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:26508797C>T	ENST00000244513.6	+	7	1042	c.976C>T	c.(976-978)Cga>Tga	p.R326*		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	326	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						AAAATCTGTTCGACTGGAAGA	0.483													7	180					0	0	1	0	0	T	26508797	C	T	26508797	4	4	48	1	0	0	0	0	0	1	0	0	1562	876	31	1	1002	1	BTN1A1	6	26508797	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	95045	26508797	144606270	1639	6033										
ZNF391	346157	broad.mit.edu	37	chr6	27369039	27369039	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctcttacagaacatcagaGaatccacagtggagaaaagc	9	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:27369039G>T	ENST00000244576.4	+	3	1435	c.890G>T	c.(889-891)aGa>aTa	p.R297I		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						GAACATCAGAGAATCCACAGT	0.478													21	34					1.87028e-06	2.10206e-06	1	1	0	T	27369039	G	T	27369039	3	4	48	1	0	0	0	0	1	0	0	0	17935	942	33	2	892	2	ZNF391	6	27369039	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	860242	27369039	143746028	1640	6034										
HIST1H2BO	8348	broad.mit.edu	37	chr6	27861429	27861429	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgaaggccatgggcatcatGaactccttcgtcaatgacat	9	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:27861429G>T	ENST00000303806.4	+	1	227	c.189G>T	c.(187-189)atG>atT	p.M63I		NM_003527.4	NP_003518.2	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	63					nucleosome assembly	nucleosome|nucleus	DNA binding										TGGGCATCATGAACTCCTTCG	0.562													25	223					1.85244e-09	2.22951e-09	1	1	0	T	27861429	G	T	27861429	3	4	48	1	0	0	0	0	1	0	0	0	7194	1290	45	2	191	2	HIST1H2BO	6	27861429	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	492390	27861429	143253638	1641	6035										
ZKSCAN4	387032	broad.mit.edu	37	chr6	28217588	28217588	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcttgcaacagagcagttCttgcccctggtcaccaacgg	9	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:28217588C>A	ENST00000377294.2	-	2	691	c.448G>T	c.(448-450)Gaa>Taa	p.E150*	ZKSCAN4_ENST00000423974.2_5'UTR	NM_019110.3	NP_061983.2	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	150					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						CAGAGCAGTTCTTGCCCCTGG	0.448													97	33					7.47877e-49	1.08552e-48	1	1	0	A	28217588	C	A	28217588	4	1	48	1	0	0	0	0	0	1	0	0	17746	922	32	2	1205	2	ZKSCAN4	6	28217588	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	356159	28217588	142897479	1642	6036										
GPX6	257202	broad.mit.edu	37	chr6	28472164	28472164	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcatgacagggactccatCgggccccaccagaaatttct	9	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:28472164C>T	ENST00000361902.1	-	5	620	c.571G>A	c.(571-573)Gat>Aat	p.D191N	GPX6_ENST00000474923.1_Silent_p.P157P	NM_182701.1	NP_874360.1	P59796	GPX6_HUMAN	glutathione peroxidase 6 (olfactory)	191					response to oxidative stress	extracellular region	glutathione peroxidase activity			NS(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19					Glutathione(DB00143)	GGGACTCCATCGGGCCCCACC	0.517													17	48					0	0	1	0	0	T	28472164	C	T	28472164	3	4	48	1	0	0	0	0	1	0	0	0	6784	884	31	1	98	1	GPX6	6	28472164	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	254576	28472164	142642903	1643	6037										
SCAND3	114821	broad.mit.edu	37	chr6	28543364	28543364	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taagatctacttggcatcttGaactaacttccttaattgat	5	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:28543364G>T	ENST00000452236.2	-	3	1735	c.1118C>A	c.(1117-1119)tCa>tAa	p.S373*		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	373	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TTGGCATCTTGAACTAACTTC	0.338													66	33					4.49795e-14	5.82898e-14	1	1	0	T	28543364	G	T	28543364	4	4	48	1	0	0	0	0	0	1	0	0	13928	1294	45	2	2867	2	SCAND3	6	28543364	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	71200	28543364	142571703	1644	6038										
OR14J1	442191	broad.mit.edu	37	chr6	29275214	29275214	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttgtagccaccttctttCtttcagctgcaggctttgag	8	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:29275214C>A	ENST00000377160.2	+	1	812	c.748C>A	c.(748-750)Ctt>Att	p.L250I		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CACCTTCTTTCTTTCAGCTGC	0.488													58	107					8.72158e-25	1.22634e-24	1	1	0	A	29275214	C	A	29275214	3	1	48	1	0	0	0	0	1	0	0	0	10995	913	32	2	750	2	OR14J1	6	29275214	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	731850	29275214	141839853	1645	6039										
GABBR1	0	broad.mit.edu	37	chr6	29577119	29577119	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgacaggaagcggaatgtCttgatgaccagggtctggtc	15	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:29577119C>A	ENST00000377034.4	-	15	2081	c.1746G>T	c.(1744-1746)aaG>aaT	p.K582N	GABBR1_ENST00000377012.4_Missense_Mutation_p.K465N|GABBR1_ENST00000376977.3_Intron|GABBR1_ENST00000355973.3_Missense_Mutation_p.K465N|GABBR1_ENST00000377016.4_Missense_Mutation_p.K520N	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	582					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	AGCGGAATGTCTTGATGACCA	0.527													49	12					1.51926e-22	2.11298e-22	1	1	0	A	29577119	C	A	29577119	3	1	48	1	0	0	0	0	1	0	0	0	6189	912	32	2	1175	2	GABBR1	6	29577119	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	301905	29577119	141537948	1646	6040										
MOG	4340	broad.mit.edu	37	chr6	29627126	29627126	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgataggaccaagacaccCtatccgggctctggtcgggg	14	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:29627126C>A	ENST00000376894.4	+	2	237	c.119C>A	c.(118-120)cCt>cAt	p.P40H	MOG_ENST00000483013.1_Intron|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000376917.3_Missense_Mutation_p.P40H|MOG_ENST00000376891.4_Missense_Mutation_p.P40H|MOG_ENST00000431798.2_Missense_Mutation_p.P40H|MOG_ENST00000490427.1_Intron|MOG_ENST00000396704.3_Missense_Mutation_p.P40H|MOG_ENST00000416766.2_Missense_Mutation_p.P40H|MOG_ENST00000376898.3_Missense_Mutation_p.P40H|MOG_ENST00000396701.2_Missense_Mutation_p.P40H|MOG_ENST00000533330.2_Missense_Mutation_p.P40H|MOG_ENST00000494692.1_Missense_Mutation_p.P40H|MOG_ENST00000376902.3_Missense_Mutation_p.P40H|MOG_ENST00000376888.2_Intron			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	40	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						CCAAGACACCCTATCCGGGCT	0.547													14	182					3.41278e-10	4.16994e-10	1	1	0	A	29627126	C	A	29627126	3	1	48	1	0	0	0	0	1	0	0	0	9741	681	24	5	125	5	MOG	6	29627126	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	50007	29627126	141487941	1647	6041										
TRIM31	11074	broad.mit.edu	37	chr6	30080518	30080518	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgacaggtttctgcagaAtgtccaggcagatggggcag	16	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:30080518A>C	ENST00000376734.3	-	2	190	c.65T>G	c.(64-66)aTt>aGt	p.I22S	TRIM31-AS1_ENST00000440874.1_RNA|TRIM31_ENST00000540829.1_Missense_Mutation_p.I22S	NM_007028.3	NP_008959.3	Q9BZY9	TRI31_HUMAN	tripartite motif containing 31	22						mitochondrion	ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(2)	15						TTTCTGCAGAATGTCCAGGCA	0.483													61	23					0	0	1	0	0	C	30080518	A	C	30080518	3	2	48	1	0	0	0	0	1	0	0	0	16565	101	4	4	1244	4	TRIM31	6	30080518	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	453392	30080518	141034549	1648	6042										
MDC1	9656	broad.mit.edu	37	chr6	30673581	30673581	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtggaggtggaagggtgggGctcaggggcagcagaggtag	23	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:30673581G>A	ENST00000376406.3	-	10	4026	c.3379C>T	c.(3379-3381)Ccc>Tcc	p.P1127S	MDC1_ENST00000376405.2_Missense_Mutation_p.P863S|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1127	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GAAGGGTGGGGCTCAGGGGCA	0.567								Other conserved DNA damage response genes					6	220					0	0	1	0	0	A	30673581	G	A	30673581	3	1	48	1	0	0	0	0	1	0	0	0	9452	1203	42	3	2914	3	MDC1	6	30673581	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	593063	30673581	140441486	1649	6043										
DDR1	780	broad.mit.edu	37	chr6	30859254	30859254	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgacggacataccgtgggCgggtaagaaaggcccctgca	14	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:30859254C>T	ENST00000324771.8	+	8	1211	c.663C>T	c.(661-663)ggC>ggT	p.G221G	DDR1_ENST00000446312.1_Intron|DDR1_ENST00000452441.1_Silent_p.G221G|DDR1_ENST00000376568.3_Silent_p.G221G|DDR1_ENST00000508472.1_3'UTR|DDR1_ENST00000376570.4_Silent_p.G221G|DDR1_ENST00000513240.1_Silent_p.G221G|DDR1_ENST00000376567.2_Silent_p.G221G|DDR1_ENST00000454612.2_Silent_p.G221G|DDR1_ENST00000508312.1_Silent_p.G239G|DDR1_ENST00000376575.3_Silent_p.G221G|DDR1_ENST00000361741.4_5'UTR|DDR1_ENST00000376569.3_Silent_p.G221G|DDR1_ENST00000418800.2_Silent_p.G221G			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	221					cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	ATACCGTGGGCGGGTAAGAAA	0.557													25	7					0	0	1	0	0	T	30859254	C	T	30859254	2	4	48	1	0	0	0	0	0	0	0	1	4359	755	27	1		1	DDR1	6	30859254	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	185673	30859254	140255813	1650	6044										
GTF2H4	2968	broad.mit.edu	37	chr6	30881673	30881673	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggcgtgctcgtgttcgaGaactcggccaagcggctcat	14	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:30881673G>T	ENST00000259895.4	+	14	1525	c.1302G>T	c.(1300-1302)gaG>gaT	p.E434D	GTF2H4_ENST00000376316.2_Missense_Mutation_p.E434D	NM_001517.4	NP_001508.1	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4, 52kDa	434					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						TCGTGTTCGAGAACTCGGCCA	0.632								Nucleotide excision repair (NER)					24	7					3.83957e-06	4.27438e-06	1	1	0	T	30881673	G	T	30881673	3	4	48	1	0	0	0	0	1	0	0	0	6905	933	33	2	1352	2	GTF2H4	6	30881673	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	22419	30881673	140233394	1651	6045										
VARS2	57176	broad.mit.edu	37	chr6	30891151	30891151	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctccctcctccccgatgGatgcctggatcctgagccgc	10	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:30891151G>A	ENST00000321897.5	+	24	2967	c.2335G>A	c.(2335-2337)Gat>Aat	p.D779N	VARS2_ENST00000416670.2_Missense_Mutation_p.D779N|VARS2_ENST00000476162.1_3'UTR|VARS2_ENST00000541562.1_Missense_Mutation_p.D809N|VARS2_ENST00000542001.1_Missense_Mutation_p.D639N			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	779					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CTCCCCGATGGATGCCTGGAT	0.657													41	16					0	0	1	0	0	A	30891151	G	A	30891151	3	1	48	1	0	0	0	0	1	0	0	0	17183	1174	41	3	2523	3	VARS2	6	30891151	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9478	30891151	140223916	1652	6046										
LY6G6F	259215	broad.mit.edu	37	chr6	31678182	31678182	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtctatgagaacatccatTtggcccgtcttgggtgagga	13	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:31678182T>C	ENST00000375832.4	+	5	878	c.856T>C	c.(856-858)Ttg>Ctg	p.L286L	XXbac-BPG32J3.20_ENST00000461287.1_Intron|LY6G6F_ENST00000556581.1_Intron|MEGT1_ENST00000503322.1_Intron	NM_001003693.1	NP_001003693.1	Q5SQ64	LY66F_HUMAN	lymphocyte antigen 6 complex, locus G6F	286						integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)	12						GAACATCCATTTGGCCCGTCT	0.542													169	56					0	0	1	0	0	C	31678182	T	C	31678182	2	2	48	1	0	0	0	0	0	0	0	1	9141	1838	64	4		4	LY6G6F	6	31678182	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	787031	31678182	139436885	1653	6047										
VPS52	6293	broad.mit.edu	37	chr6	33235673	33235673	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagccgccccaggtaagagCggtagtaagacaggtaaatc	13	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:33235673C>T	ENST00000445902.2	-	9	1120	c.902G>A	c.(901-903)cGc>cAc	p.R301H	VPS52_ENST00000478934.1_5'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.R176H|VPS52_ENST00000482399.1_3'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	301					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						CAGGTAAGAGCGGTAGTAAGA	0.527													74	30					0	0	1	0	0	T	33235673	C	T	33235673	3	4	48	1	0	0	0	0	1	0	0	0	17273	768	27	1	1317	1	VPS52	6	33235673	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1557491	33235673	137879394	1654	6048										
VPS52	6293	broad.mit.edu	37	chr6	33236869	33236869	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcctggcgatttcgaagtCgaatgttcatggctcctgac	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:33236869C>T	ENST00000445902.2	-	6	688	c.470G>A	c.(469-471)cGa>cAa	p.R157Q	VPS52_ENST00000478934.1_5'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.R32Q|VPS52_ENST00000482399.1_3'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	157					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						ATTTCGAAGTCGAATGTTCAT	0.537													118	46					0	0	1	0	0	T	33236869	C	T	33236869	3	4	48	1	0	0	0	0	1	0	0	0	17273	884	31	1	1761	1	VPS52	6	33236869	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1196	33236869	137878198	1655	6049										
GRM4	2914	broad.mit.edu	37	chr6	34026885	34026885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcctgtctggttggcccttCgtgctgcctccagcacacgc	12	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:34026885C>T	ENST00000374181.3	-	4	1062	c.893G>A	c.(892-894)cGa>cAa	p.R298Q	GRM4_ENST00000374177.3_Missense_Mutation_p.R229Q|GRM4_ENST00000535756.1_Missense_Mutation_p.R165Q|GRM4_ENST00000544773.1_Missense_Mutation_p.R129Q|GRM4_ENST00000545715.1_5'UTR|GRM4_ENST00000538487.1_Missense_Mutation_p.R298Q|GRM4_ENST00000455714.2_Missense_Mutation_p.R158Q	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	298					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GTTGGCCCTTCGTGCTGCCTC	0.622													17	25					0	0	1	0	0	T	34026885	C	T	34026885	3	4	48	1	0	0	0	0	1	0	0	0	6839	884	31	1	1873	1	GRM4	6	34026885	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	790016	34026885	137088182	1656	6050										
FANCE	2178	broad.mit.edu	37	chr6	35425738	35425738	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccagttgagctacagcttCttcacgaatgtagtcccagc	8	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:35425738C>A	ENST00000229769.2	+	4	1131	c.946C>A	c.(946-948)Ctt>Att	p.L316I		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	316	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						GCTACAGCTTCTTCACGAATG	0.498			"N, F, S"			"AML, leukemia"		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				42	16					2.37825e-27	3.36934e-27	1	1	0	A	35425738	C	A	35425738	3	1	48	1	0	0	0	0	1	0	0	0	5698	913	32	2	960	2	FANCE	6	35425738	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1398853	35425738	135689329	1657	6051										
KCTD20	222658	broad.mit.edu	37	chr6	36442758	36442758	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccattcccaagcaccagagaAagtgacgcttcttgtagatg	9	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:36442758A>C	ENST00000373731.2	+	3	744	c.353A>C	c.(352-354)aAa>aCa	p.K118T	KCTD20_ENST00000536244.1_Intron|KCTD20_ENST00000474988.1_Intron|KCTD20_ENST00000544295.1_Intron|KCTD20_ENST00000449081.2_Intron	NM_173562.3	NP_775833.2	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerization domain containing 20	118	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|skin(1)	15						GCACCAGAGAAAGTGACGCTT	0.433													5	60					0	0	1	0	0	C	36442758	A	C	36442758	3	2	48	1	0	0	0	0	1	0	0	0	8151	14	1	4	359	4	KCTD20	6	36442758	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1017020	36442758	134672309	1658	6052										
DNAH8	1769	broad.mit.edu	37	chr6	38750826	38750826	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacggtaaagctgtcatccGtcagtataacaagatctcct	9	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:38750826G>A	ENST00000359357.3	+	15	1909	c.1655G>A	c.(1654-1656)cGt>cAt	p.R552H	DNAH8_ENST00000449981.2_Missense_Mutation_p.R769H|DNAH8_ENST00000441566.1_Missense_Mutation_p.R552H					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GCTGTCATCCGTCAGTATAAC	0.383													16	33					0	0	1	0	0	A	38750826	G	A	38750826	3	1	48	1	0	0	0	0	1	0	0	0	4634	1145	40	1	1705	1	DNAH8	6	38750826	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2308068	38750826	132364241	1659	6053										
DNAH8	1769	broad.mit.edu	37	chr6	38810148	38810148	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttactttgtttcccagaaaaGaactcaacttgctgcagaag	7	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:38810148G>T	ENST00000359357.3	+	32	4074	c.3820G>T	c.(3820-3822)Gaa>Taa	p.E1274*	DNAH8_ENST00000449981.2_Nonsense_Mutation_p.E1491*|DNAH8_ENST00000441566.1_Nonsense_Mutation_p.E1274*					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCCCAGAAAAGAACTCAACTT	0.323													34	16					3.03874e-20	4.1594e-20	1	1	0	T	38810148	G	T	38810148	4	4	48	1	0	0	0	0	0	1	0	0	4634	943	33	2	3938	2	DNAH8	6	38810148	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	59322	38810148	132304919	1660	6054										
DNAH8	1769	broad.mit.edu	37	chr6	38810576	38810576	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaacagagacactgggataGaatctccgagttaactggaa	11	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:38810576G>T	ENST00000359357.3	+	33	4345	c.4091G>T	c.(4090-4092)aGa>aTa	p.R1364I	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1581I|DNAH8_ENST00000441566.1_Missense_Mutation_p.R1364I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CACTGGGATAGAATCTCCGAG	0.383													51	15					8.94452e-30	1.27491e-29	1	1	0	T	38810576	G	T	38810576	3	4	48	1	0	0	0	0	1	0	0	0	4634	942	33	2	4213	2	DNAH8	6	38810576	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	428	38810576	132304491	1661	6055										
DNAH8	1769	broad.mit.edu	37	chr6	38813386	38813386	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccattaaggagaaggatatcGaagccaagctgactcaggtg	12	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:38813386G>A	ENST00000359357.3	+	34	4485	c.4231G>A	c.(4231-4233)Gaa>Aaa	p.E1411K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E1628K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E1411K					dynein, axonemal, heavy chain 8									p.E1411K(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GAAGGATATCGAAGCCAAGCT	0.388													53	25					0	0	1	0	0	A	38813386	G	A	38813386	3	1	48	1	0	0	0	0	1	0	0	0	4634	1059	37	1	4357	1	DNAH8	6	38813386	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2810	38813386	132301681	1662	6056										
DNAH8	1769	broad.mit.edu	37	chr6	38913287	38913287	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtcctcccaaaccctatCgctggatccttgacatgact	6	16	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:38913287C>T	ENST00000359357.3	+	78	11655	c.11401C>T	c.(11401-11403)Cgc>Tgc	p.R3801C	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.R4018C|DNAH8_ENST00000441566.1_Missense_Mutation_p.R3765C					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CAAACCCTATCGCTGGATCCT	0.483													60	23					0	0	1	0	0	T	38913287	C	T	38913287	3	4	48	1	0	0	0	0	1	0	0	0	4634	884	31	1	11703	1	DNAH8	6	38913287	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	99901	38913287	132201780	1663	6057										
LRFN2	57497	broad.mit.edu	37	chr6	40399910	40399910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggataagggggctggggtCcccaatggctttgcacttga	16	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:40399910C>T	ENST00000338305.6	-	2	1485	c.943G>A	c.(943-945)Gac>Aac	p.D315N		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	315	Ig-like.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGGCTGGGGTCCCCAATGGCT	0.597													21	47					0	0	1	0	0	T	40399910	C	T	40399910	3	4	48	1	0	0	0	0	1	0	0	0	8982	855	30	3	1434	3	LRFN2	6	40399910	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1486623	40399910	130715157	1664	6058										
TAF8	129685	broad.mit.edu	37	chr6	42023720	42023720	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacactctccctgcttatgCaaaacggtctcagaggatgg	11	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:42023720C>A	ENST00000372977.3	+	4	350	c.332C>A	c.(331-333)gCa>gAa	p.A111E	TAF8_ENST00000456846.2_Missense_Mutation_p.A111E|TAF8_ENST00000472818.1_Missense_Mutation_p.A111E|TAF8_ENST00000494547.1_Missense_Mutation_p.A111E|TAF8_ENST00000465926.1_Missense_Mutation_p.A48E|TAF8_ENST00000372982.4_Missense_Mutation_p.A111E|TAF8_ENST00000372978.3_Missense_Mutation_p.A111E|TAF8_ENST00000482432.1_Missense_Mutation_p.A48E|TAF8_ENST00000482926.1_3'UTR	NM_138572.2	NP_612639.2	Q7Z7C8	TAF8_HUMAN	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	111					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			CCTGCTTATGCAAAACGGTCT	0.388													34	19					6.05902e-23	8.45196e-23	1	1	0	A	42023720	C	A	42023720	3	1	48	1	0	0	0	0	1	0	0	0	15590	710	25	5	346	5	TAF8	6	42023720	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1623810	42023720	129091347	1665	6059										
ABCC10	89845	broad.mit.edu	37	chr6	43406363	43406363	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcgcctggctctctgcaggCtgcgtgggcatgtggcagtg	16	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:43406363C>T	ENST00000244533.3	+	6	2232	c.1871_splice	c.e6-1	p.L625_splice	ABCC10_ENST00000372530.4_Splice_Site_p.L653_splice	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	653	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCTCTGCAGGCTGCGTGGGCA	0.622													14	39					0	0	1	0	0	T	43406363	C	T	43406363	5	4	48	1	0	0	0	0	0	0	1	0	50	811	28	3	1895	3	ABCC10	6	43406363	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1382643	43406363	127708704	1666	6060										
XPO5	57510	broad.mit.edu	37	chr6	43501728	43501728	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctagcatttctggtgcatAtaatgtattgtgggttctga	12	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:43501728A>G	ENST00000265351.7	-	21	2569	c.2359T>C	c.(2359-2361)Tat>Cat	p.Y787H		NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	787					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TCTGGTGCATATAATGTATTG	0.403													23	51					0	0	1	0	0	G	43501728	A	G	43501728	3	3	48	1	0	0	0	0	1	0	0	0	17506	449	16	4	1303	4	XPO5	6	43501728	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	95365	43501728	127613339	1667	6061										
TMEM63B	55362	broad.mit.edu	37	chr6	44117685	44117685	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctactactcagccttcttTgaagcccactggacacggta	8	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:44117685T>C	ENST00000259746.9	+	16	1686	c.1503T>C	c.(1501-1503)ttT>ttC	p.F501F	TMEM63B_ENST00000323267.6_Silent_p.F501F			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	501						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CAGCCTTCTTTGAAGCCCACT	0.597													5	21					0	0	1	0	0	C	44117685	T	C	44117685	2	2	48	1	0	0	0	0	0	0	0	1	16250	1809	63	4		4	TMEM63B	6	44117685	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	615957	44117685	126997382	1668	6062										
SPATS1	221409	broad.mit.edu	37	chr6	44310906	44310906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctcaagcacgacctgcgGcagacagctggagaaggttc	12	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:44310906G>A	ENST00000288390.2	+	1	421	c.74G>A	c.(73-75)gGc>gAc	p.G25D	SPATS1_ENST00000323108.8_Missense_Mutation_p.G25D			Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	25										NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(5)|skin(1)|urinary_tract(1)	14	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACGACCTGCGGCAGACAGCTG	0.517													23	49					0	0	1	0	0	A	44310906	G	A	44310906	3	1	48	1	0	0	0	0	1	0	0	0	15073	1203	42	3	76	3	SPATS1	6	44310906	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	193221	44310906	126804161	1669	6063										
CDC5L	988	broad.mit.edu	37	chr6	44393877	44393877	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgtgtaaaggaaatgaaacGaatgcataaagctgtccaga	11	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:44393877G>A	ENST00000371477.3	+	12	1906	c.1607G>A	c.(1606-1608)cGa>cAa	p.R536Q		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	536	Interaction with DAPK3 (By similarity).|Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAAATGAAACGAATGCATAAA	0.348													13	32					0	0	1	0	0	A	44393877	G	A	44393877	3	1	48	1	0	0	0	0	1	0	0	0	3104	1058	37	1	1653	1	CDC5L	6	44393877	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	82971	44393877	126721190	1670	6064										
CYP39A1	51302	broad.mit.edu	37	chr6	46555824	46555824	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatttctatgcagccaaaAtggagacaacatcaacaagt	8	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46555824A>C	ENST00000275016.2	-	9	1311	c.1108T>G	c.(1108-1110)Ttt>Gtt	p.F370V		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	370					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						TGCAGCCAAAATGGAGACAAC	0.289													16	29					0	0	1	0	0	C	46555824	A	C	46555824	3	2	48	1	0	0	0	0	1	0	0	0	4200	101	4	4	317	4	CYP39A1	6	46555824	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2161947	46555824	124559243	1671	6065										
TDRD6	221400	broad.mit.edu	37	chr6	46659193	46659193	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctgatcatataccagaaGaagtggtggtgtggtttcag	12	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46659193G>T	ENST00000544460.1	+	1	3582	c.3328G>T	c.(3328-3330)Gaa>Taa	p.E1110*	TDRD6_ENST00000316081.6_Nonsense_Mutation_p.E1110*	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1110					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TATACCAGAAGAAGTGGTGGT	0.378													35	70					4.62619e-21	6.37263e-21	1	1	0	T	46659193	G	T	46659193	4	4	48	1	0	0	0	0	0	1	0	0	15792	943	33	2	3330	2	TDRD6	6	46659193	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	103369	46659193	124455874	1672	6066										
TDRD6	221400	broad.mit.edu	37	chr6	46660805	46660805	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttcagaaggattatgttCtcaagagggaaatgactatt	9	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46660805C>A	ENST00000544460.1	+	1	5194	c.4940C>A	c.(4939-4941)tCt>tAt	p.S1647Y	TDRD6_ENST00000316081.6_Missense_Mutation_p.S1647Y	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1647					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GGATTATGTTCTCAAGAGGGA	0.393													26	50					3.73148e-12	4.68978e-12	1	1	0	A	46660805	C	A	46660805	3	1	48	1	0	0	0	0	1	0	0	0	15792	913	32	2	4942	2	TDRD6	6	46660805	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1612	46660805	124454262	1673	6067										
PLA2G7	7941	broad.mit.edu	37	chr6	46678377	46678377	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgagagcttgggaacattCttttgctctttgccgtacct	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46678377C>T	ENST00000274793.7	-	8	878	c.682G>A	c.(682-684)Gaa>Aaa	p.E228K	PLA2G7_ENST00000541026.1_Missense_Mutation_p.E101K|PLA2G7_ENST00000538237.1_Missense_Mutation_p.E183K|PLA2G7_ENST00000537365.1_Missense_Mutation_p.E228K	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	228					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			TGGGAACATTCTTTTGCTCTT	0.323													4	47					0	0	1	0	0	T	46678377	C	T	46678377	3	4	48	1	0	0	0	0	1	0	0	0	12056	922	32	3	663	3	PLA2G7	6	46678377	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17572	46678377	124436690	1674	6068										
PLA2G7	7941	broad.mit.edu	37	chr6	46679328	46679328	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcagcagattggtccttgaAatagtaagttgcagatgcag	12	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46679328A>C	ENST00000274793.7	-	7	764	c.568T>G	c.(568-570)Ttc>Gtc	p.F190V	PLA2G7_ENST00000541026.1_Missense_Mutation_p.F63V|PLA2G7_ENST00000538237.1_Missense_Mutation_p.F145V|PLA2G7_ENST00000537365.1_Missense_Mutation_p.F190V	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	190					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			TGGTCCTTGAAATAGTAAGTT	0.413													44	74					0	0	1	0	0	C	46679328	A	C	46679328	3	2	48	1	0	0	0	0	1	0	0	0	12056	14	1	4	781	4	PLA2G7	6	46679328	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	951	46679328	124435739	1675	6069										
PLA2G7	7941	broad.mit.edu	37	chr6	46682224	46682224	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccaagaccatgagaaaaaAcaacaagtggatatttttca	6	9	1	2	rs149733733		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46682224A>G	ENST00000274793.7	-	5	639	c.443T>C	c.(442-444)gTt>gCt	p.V148A	PLA2G7_ENST00000541026.1_Missense_Mutation_p.V21A|PLA2G7_ENST00000538237.1_Missense_Mutation_p.V103A|PLA2G7_ENST00000537365.1_Missense_Mutation_p.V148A	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	148					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			ATGAGAAAAAACAACAAGTGG	0.368													4	75					0	0	1	0	0	G	46682224	A	G	46682224	3	3	48	1	0	0	0	0	1	0	0	0	12056	43	2	4	914	4	PLA2G7	6	46682224	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2896	46682224	124432843	1676	6070										
GPR116	221395	broad.mit.edu	37	chr6	46826811	46826811	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgcctgaagggctattgttCttaaaagtcattgaaatcct	8	9	2	2	rs144073167		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46826811C>A	ENST00000283296.7	-	17	3117	c.2829G>T	c.(2827-2829)aaG>aaT	p.K943N	GPR116_ENST00000456426.2_Missense_Mutation_p.K801N|GPR116_ENST00000362015.4_Missense_Mutation_p.K943N|GPR116_ENST00000265417.7_Missense_Mutation_p.K943N|GPR116_ENST00000545669.1_Missense_Mutation_p.K372N	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	943					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			GGCTATTGTTCTTAAAAGTCA	0.473													24	45					7.33628e-21	1.00811e-20	1	1	0	A	46826811	C	A	46826811	3	1	48	1	0	0	0	0	1	0	0	0	6672	912	32	2	1231	2	GPR116	6	46826811	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	144587	46826811	124288256	1677	6071										
GPR110	266977	broad.mit.edu	37	chr6	46979827	46979827	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgacaccaccgaagccagAttccccactgtggttgatgg	10	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46979827A>C	ENST00000371253.2	-	10	1247	c.1032T>G	c.(1030-1032)aaT>aaG	p.N344K	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000283297.5_Missense_Mutation_p.N147K	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	344					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CCGAAGCCAGATTCCCCACTG	0.483													40	65					0	0	1	0	0	C	46979827	A	C	46979827	3	2	48	1	0	0	0	0	1	0	0	0	6666	330	12	4	1724	4	GPR110	6	46979827	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	153016	46979827	124135240	1678	6072										
GPR110	266977	broad.mit.edu	37	chr6	46995498	46995498	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttgatgccatcatttttCtgttaaaaagaaaaaaaata	5	4	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:46995498C>T	ENST00000371253.2	-	3	285		c.e3-1		GPR110_ENST00000449332.2_Intron|GPR110_ENST00000371243.2_Splice_Site	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CATCATTTTTCTGTTAAAAAG	0.343													8	36					0	0	1	0	0	T	46995498	C	T	46995498	5	4	48	1	0	0	0	0	0	0	1	0	6666	927	32	3	2765	3	GPR110	6	46995498	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15671	46995498	124119569	1679	6073										
TNFRSF21	27242	broad.mit.edu	37	chr6	47200581	47200581	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcttgactccaataatttCgaatagccggtctagtttgt	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:47200581C>T	ENST00000296861.2	-	6	2281	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	630					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity	p.E630K(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			CCAATAATTTCGAATAGCCGG	0.493													73	117					0	0	1	0	0	T	47200581	C	T	47200581	3	4	48	1	0	0	0	0	1	0	0	0	16354	893	31	1	83	1	TNFRSF21	6	47200581	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	205083	47200581	123914486	1680	6074										
CD2AP	23607	broad.mit.edu	37	chr6	47547185	47547185	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaggagtatttccagacaAttttgctgtccagataaatg	9	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:47547185A>C	ENST00000359314.5	+	9	1424	c.968A>C	c.(967-969)aAt>aCt	p.N323T		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	323	SH3 3.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton	p.N323I(1)		kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TTTCCAGACAATTTTGCTGTC	0.348													19	29					0	0	1	0	0	C	47547185	A	C	47547185	3	2	48	1	0	0	0	0	1	0	0	0	3016	101	4	4	1002	4	CD2AP	6	47547185	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	346604	47547185	123567882	1681	6075										
OPN5	221391	broad.mit.edu	37	chr6	47776108	47776108	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtggtttgaaagcaaccaaGaagaagtctctggaaggctt	13	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:47776108G>T	ENST00000489301.2	+	5	1060	c.975G>T	c.(973-975)aaG>aaT	p.K325N	OPN5_ENST00000371211.2_Missense_Mutation_p.K325N|OPN5_ENST00000244799.4_3'UTR|OPN5_ENST00000393699.2_Missense_Mutation_p.K325N			Q6U736	OPN5_HUMAN	opsin 5	325					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						AAGCAACCAAGAAGAAGTCTC	0.413													7	68					8.12818e-05	8.79784e-05	1	1	0	T	47776108	G	T	47776108	3	4	48	1	0	0	0	0	1	0	0	0	10930	933	33	2	993	2	OPN5	6	47776108	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	228923	47776108	123338959	1682	6076										
CRISP1	167	broad.mit.edu	37	chr6	49803104	49803104	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtggttgcatcccagataAtggacttgtatgtcacagtc	11	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:49803104A>G	ENST00000335847.4	-	8	776	c.675T>C	c.(673-675)caT>caC	p.H225H	CRISP1_ENST00000536021.1_3'UTR|CRISP1_ENST00000329411.5_3'UTR|CRISP1_ENST00000355791.2_Silent_p.H225H|CRISP1_ENST00000505118.1_Silent_p.H225H|CRISP1_ENST00000507853.1_3'UTR	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	225					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					ATCCCAGATAATGGACTTGTA	0.363													6	88					0	0	1	0	0	G	49803104	A	G	49803104	2	3	48	1	0	0	0	0	0	0	0	1	3902	98	4	4		4	CRISP1	6	49803104	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2026996	49803104	121311963	1683	6077										
PKHD1	5314	broad.mit.edu	37	chr6	51524480	51524480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttccccaatagaaaaaagcGcaaaacttgaggagtttgat	9	7	0	3	rs148617572		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:51524480G>A	ENST00000371117.3	-	61	10719	c.10444C>T	c.(10444-10446)Cgc>Tgc	p.R3482C		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3482			R -> C (in ARPKD).		cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.R3482C(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGAAAAAAGCGCAAAACTTGA	0.443													30	40					0	0	1	0	0	A	51524480	G	A	51524480	3	1	48	1	0	0	0	0	1	0	0	0	12018	1087	38	1	1808	1	PKHD1	6	51524480	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1721376	51524480	119590587	1684	6078										
PKHD1	5314	broad.mit.edu	37	chr6	51524753	51524753	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggtatgtacatttctgttCttctctaaatgtacctataa	5	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:51524753C>T	ENST00000371117.3	-	61	10446	c.10171G>A	c.(10171-10173)Gaa>Aaa	p.E3391K		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3391					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.E3391*(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CATTTCTGTTCTTCTCTAAAT	0.348													9	14					0	0	1	0	0	T	51524753	C	T	51524753	3	4	48	1	0	0	0	0	1	0	0	0	12018	922	32	3	2081	3	PKHD1	6	51524753	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	273	51524753	119590314	1685	6079										
PKHD1	5314	broad.mit.edu	37	chr6	51612695	51612695	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggccacagaataccaattCgacctcctcttggattggag	9	12	1	1	rs146649803		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:51612695C>T	ENST00000371117.3	-	58	9994	c.9719G>A	c.(9718-9720)cGa>cAa	p.R3240Q	PKHD1_ENST00000340994.4_Missense_Mutation_p.R3240Q	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3240					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.R3240Q(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AATACCAATTCGACCTCCTCT	0.478													47	62					0	0	1	0	0	T	51612695	C	T	51612695	3	4	48	1	0	0	0	0	1	0	0	0	12018	884	31	1	2584	1	PKHD1	6	51612695	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	87942	51612695	119502372	1686	6080										
MCM3	4172	broad.mit.edu	37	chr6	52138700	52138700	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaatgttctccattggagtCttatactggtcatactgggg	10	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:52138700C>T	ENST00000596288.1	-	10	1551	c.1524G>A	c.(1522-1524)aaG>aaA	p.K508K	MCM3_ENST00000419835.2_Silent_p.K417K|MCM3_ENST00000229854.7_Silent_p.K463K	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	463					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					CCATTGGAGTCTTATACTGGT	0.483													20	41					0	0	1	0	0	T	52138700	C	T	52138700	2	4	48	1	0	0	0	0	0	0	0	1	9436	912	32	3		3	MCM3	6	52138700	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	526005	52138700	118976367	1687	6081										
LRRC1	55227	broad.mit.edu	37	chr6	53785453	53785453	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgctgtggtgcactggagaActtggtaaatgatgtctctg	13	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:53785453A>C	ENST00000370888.1	+	13	1587	c.1310A>C	c.(1309-1311)aAc>aCc	p.N437T	RP3-523E19.2_ENST00000474641.2_RNA	NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	437						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GCACTGGAGAACTTGGTAAAT	0.463													10	46					0	0	1	0	0	C	53785453	A	C	53785453	3	2	48	1	0	0	0	0	1	0	0	0	9010	43	2	4	1360	4	LRRC1	6	53785453	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1646753	53785453	117329614	1688	6082										
FAM83B	222584	broad.mit.edu	37	chr6	54804852	54804852	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcacggatacaaacctcaTtttgttcctaactttaatgg	6	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:54804852T>G	ENST00000306858.7	+	5	1199	c.1083T>G	c.(1081-1083)caT>caG	p.H361Q		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	361										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					ACAAACCTCATTTTGTTCCTA	0.343													6	65					0	0	1	0	0	G	54804852	T	G	54804852	3	3	48	1	0	0	0	0	1	0	0	0	5665	1490	52	4	1097	4	FAM83B	6	54804852	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1019399	54804852	116310215	1689	6083										
FAM83B	222584	broad.mit.edu	37	chr6	54806276	54806276	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaaagcattcttcctcatCgaattctcaaggcagcatcc	6	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:54806276C>T	ENST00000306858.7	+	5	2623	c.2507C>T	c.(2506-2508)tCg>tTg	p.S836L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	836	Poly-Ser.									autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TCTTCCTCATCGAATTCTCAA	0.383													12	23					0	0	1	0	0	T	54806276	C	T	54806276	3	4	48	1	0	0	0	0	1	0	0	0	5665	893	31	1	2521	1	FAM83B	6	54806276	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1424	54806276	116308791	1690	6084										
HCRTR2	3062	broad.mit.edu	37	chr6	55039482	55039482	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccctttttaaaccccaccGactatgacgacgaggaattc	7	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:55039482G>A	ENST00000370862.3	+	1	433	c.97G>A	c.(97-99)Gac>Aac	p.D33N		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	33					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAACCCCACCGACTATGACGA	0.537													48	97					0	0	1	0	0	A	55039482	G	A	55039482	3	1	48	1	0	0	0	0	1	0	0	0	7042	1058	37	1	99	1	HCRTR2	6	55039482	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	233206	55039482	116075585	1691	6085										
HCRTR2	3062	broad.mit.edu	37	chr6	55113604	55113604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtccctttgcaaagtgattCcttatctacaggtaattgtt	7	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:55113604C>T	ENST00000370862.3	+	2	727	c.391C>T	c.(391-393)Cct>Tct	p.P131S		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	131					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CAAAGTGATTCCTTATCTACA	0.428													46	84					0	0	1	0	0	T	55113604	C	T	55113604	3	4	48	1	0	0	0	0	1	0	0	0	7042	855	30	3	397	3	HCRTR2	6	55113604	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	74122	55113604	116001463	1692	6086										
DST	667	broad.mit.edu	37	chr6	56417403	56417403	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcaaactctgcgaactgaGaaaacatttctcgaatggta	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:56417403G>T	ENST00000370754.5	-	61	16093	c.16094C>A	c.(16093-16095)tCt>tAt	p.S5365Y	DST_ENST00000361203.3_Missense_Mutation_p.S5185Y|DST_ENST00000244364.6_Missense_Mutation_p.S2773Y|DST_ENST00000446842.2_Missense_Mutation_p.S4861Y|DST_ENST00000370769.4_Missense_Mutation_p.S5187Y|DST_ENST00000312431.6_3'UTR|DST_ENST00000421834.2_Missense_Mutation_p.S3099Y|DST_ENST00000370788.2_Missense_Mutation_p.S3099Y			Q03001	DYST_HUMAN	dystonin	5185					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGCGAACTGAGAAAACATTTC	0.408													15	16					0.000219431	0.000235335	1	1	0	T	56417403	G	T	56417403	3	4	48	1	0	0	0	0	1	0	0	0	4809	942	33	2	7369	2	DST	6	56417403	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1303799	56417403	114697664	1693	6087										
DST	667	broad.mit.edu	37	chr6	56470005	56470005	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttggaaactgatgtgtcaaAaatttcttcaagattctcaa	6	6	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:56470005A>C	ENST00000370754.5	-	39	9321	c.9322T>G	c.(9322-9324)Ttt>Gtt	p.F3108V	DST_ENST00000361203.3_Missense_Mutation_p.F2930V|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Missense_Mutation_p.F2604V|DST_ENST00000370769.4_Missense_Mutation_p.F2930V|DST_ENST00000312431.6_Missense_Mutation_p.F2930V|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron			Q03001	DYST_HUMAN	dystonin	2930					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GATGTGTCAAAAATTTCTTCA	0.338													8	14					0	0	1	0	0	C	56470005	A	C	56470005	3	2	48	1	0	0	0	0	1	0	0	0	4809	29	1	4		4	DST	6	56470005	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	52602	56470005	114645062	1694	6088										
DST	667	broad.mit.edu	37	chr6	56484298	56484298	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctaattctttctcatctcGaaaagaatgaatttgtgaat	5	6	4	3	rs141517051		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:56484298G>A	ENST00000370765.6	-	23	4641	c.4534C>T	c.(4534-4536)Cga>Tga	p.R1512*	DST_ENST00000370754.5_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	5191					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCTCATCTCGAAAAGAATGA	0.338													8	21					0	0	1	0	0	A	56484298	G	A	56484298	4	1	48	1	0	0	0	0	0	1	0	0	4809	1066	37	1	15869	1	DST	6	56484298	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	14293	56484298	114630769	1695	6089										
DST	667	broad.mit.edu	37	chr6	56485398	56485398	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttagttcagctaccattCtttccaactcacttatcttt	2	12	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:56485398C>A	ENST00000370765.6	-	23	3541	c.3434G>T	c.(3433-3435)aGa>aTa	p.R1145I	DST_ENST00000370754.5_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1476					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGCTACCATTCTTTCCAACTC	0.433													42	88					1.59932e-28	2.27211e-28	1	1	0	A	56485398	C	A	56485398	3	1	48	1	0	0	0	0	1	0	0	0	4809	913	32	2	16969	2	DST	6	56485398	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1100	56485398	114629669	1696	6090										
BEND6	221336	broad.mit.edu	37	chr6	56882055	56882055	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaacaagagcaagcctcaGaagtttattaatgatttaat	7	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:56882055G>T	ENST00000370746.3	+	5	839	c.570G>T	c.(568-570)caG>caT	p.Q190H	BEND6_ENST00000370750.2_3'UTR|BEND6_ENST00000484701.1_3'UTR|BEND6_ENST00000545789.1_Missense_Mutation_p.Q92H	NM_152731.2	NP_689944.2	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	190	BEN.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						GCAAGCCTCAGAAGTTTATTA	0.388													7	15					3.09899e-07	3.54467e-07	1	1	0	T	56882055	G	T	56882055	3	4	48	1	0	0	0	0	1	0	0	0	1400	933	33	2	584	2	BEND6	6	56882055	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	396657	56882055	114233012	1697	6091										
BEND6	221336	broad.mit.edu	37	chr6	56882100	56882100	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtactttacacaaatgaataCatggccactcacagcctgac	6	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:56882100C>T	ENST00000370746.3	+	5	884	c.615C>T	c.(613-615)taC>taT	p.Y205Y	BEND6_ENST00000370750.2_3'UTR|BEND6_ENST00000484701.1_3'UTR|BEND6_ENST00000545789.1_Silent_p.Y107Y	NM_152731.2	NP_689944.2	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	205	BEN.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						CAAATGAATACATGGCCACTC	0.393													9	19					0	0	1	0	0	T	56882100	C	T	56882100	2	4	48	1	0	0	0	0	0	0	0	1	1400	489	17	3		3	BEND6	6	56882100	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	45	56882100	114232967	1698	6092										
ZNF451	26036	broad.mit.edu	37	chr6	57013143	57013143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaaggaaaactgtggtttCgctgcagtttatgttcggca	11	6	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:57013143C>T	ENST00000370706.4	+	10	2504	c.2260C>T	c.(2260-2262)Cgc>Tgc	p.R754C	RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.R754C|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.R754C|RP11-203B9.4_ENST00000585792.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	754					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ACTGTGGTTTCGCTGCAGTTT	0.413													11	21					0	0	1	0	0	T	57013143	C	T	57013143	3	4	48	1	0	0	0	0	1	0	0	0	17978	884	31	1	2298	1	ZNF451	6	57013143	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	131043	57013143	114101924	1699	6093										
ZNF451	26036	broad.mit.edu	37	chr6	57015659	57015659	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatttatttggggctttcaAggtacggttaataagaaaaa	9	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:57015659A>C	ENST00000370706.4	+	11	2995	c.2752_splice	c.e11+1	p.Q917_splice	RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000589263.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000586466.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|ZNF451_ENST00000357489.3_Intron|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000491832.2_Splice_Site_p.Q917_splice|RP11-203B9.4_ENST00000585792.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	917					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GGGGCTTTCAAGGTACGGTTA	0.353													5	83					0	0	1	0	0	C	57015659	A	C	57015659	5	2	48	1	0	0	0	0	0	0	1	0	17978	86	3	4	2793	4	ZNF451	6	57015659	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2516	57015659	114099408	1700	6094										
PRIM2	5558	broad.mit.edu	37	chr6	57183336	57183336	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccttcagttttacttgcaGccaccttctgaaaacatatc	5	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:57183336G>A	ENST00000607273.1	+	2	180	c.93G>A	c.(91-93)caG>caA	p.Q31Q	PRIM2_ENST00000389488.2_3'UTR	NM_000947.2	NP_000938.2	P49643	PRI2_HUMAN	primase, DNA, polypeptide 2 (58kDa)	31					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTTACTTGCAGCCACCTTCTG	0.368													4	8					0	0	1	0	0	A	57183336	G	A	57183336	2	1	48	1	0	0	0	0	0	0	0	1	12542	962	34	3		3	PRIM2	6	57183336	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	167677	57183336	113931731	1701	6095										
KHDRBS2	202559	broad.mit.edu	37	chr6	62995813	62995813	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagatggatccaggctatctTtctctgccatcagctcaggc	9	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:62995813T>C	ENST00000281156.4	-	1	319	c.41A>G	c.(40-42)aAa>aGa	p.K14R		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	14					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		CAGGCTATCTTTCTCTGCCAT	0.587													12	28					0	0	1	0	0	C	62995813	T	C	62995813	3	2	48	1	0	0	0	0	1	0	0	0	8188	1841	64	4	1044	4	KHDRBS2	6	62995813	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5812477	62995813	108119254	1702	6096										
LGSN	51557	broad.mit.edu	37	chr6	64004906	64004906	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgtccttcttaatgtgttCatgctgttggcttcagtctc	8	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:64004906C>A	ENST00000370658.5	-	2	108	c.75G>T	c.(73-75)atG>atT	p.M25I	LGSN_ENST00000370657.4_Missense_Mutation_p.M25I	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	25					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	TTAATGTGTTCATGCTGTTGG	0.343													12	29					0.00010058	0.000108553	1	1	0	A	64004906	C	A	64004906	3	1	48	1	0	0	0	0	1	0	0	0	8798	826	29	2	1466	2	LGSN	6	64004906	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1009093	64004906	107110161	1703	6097										
EYS	346007	broad.mit.edu	37	chr6	66200576	66200576	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacatgtggttgacactggCcaattatttctgagcaattc	9	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:66200576C>T	ENST00000503581.1	-	5	1310	c.773G>A	c.(772-774)gGc>gAc	p.G258D	EYS_ENST00000370616.2_Missense_Mutation_p.G258D|EYS_ENST00000370618.3_Missense_Mutation_p.G258D|EYS_ENST00000370621.3_Missense_Mutation_p.G258D|EYS_ENST00000342421.5_Missense_Mutation_p.G258D|EYS_ENST00000393380.2_Missense_Mutation_p.G258D	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	258	EGF-like 3.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						TTGACACTGGCCAATTATTTC	0.303													5	22					0	0	1	0	0	T	66200576	C	T	66200576	3	4	48	1	0	0	0	0	1	0	0	0	5360	739	26	3	8779	3	EYS	6	66200576	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2195670	66200576	104914491	1704	6098										
LMBRD1	55788	broad.mit.edu	37	chr6	70386119	70386119	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctactccttcaataaccgaTttcttccctttacaacagga	3	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:70386119T>G	ENST00000370577.3	-	16	1783	c.1554A>C	c.(1552-1554)aaA>aaC	p.K518N	LMBRD1_ENST00000370570.1_Missense_Mutation_p.K445N	NM_018368.3	NP_060838.3	Q9NUN5	LMBD1_HUMAN	LMBR1 domain containing 1	518					interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	31						CAATAACCGATTTCTTCCCTT	0.323													8	25					0	0	1	0	0	G	70386119	T	G	70386119	3	3	48	1	0	0	0	0	1	0	0	0	8882	1490	52	4	72	4	LMBRD1	6	70386119	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4185543	70386119	100728948	1705	6099										
COL19A1	1310	broad.mit.edu	37	chr6	70859890	70859890	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctctgttttcagggagttCcagggagagatggaaagcca	13	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:70859890C>A	ENST00000322773.4	+	30	2092	c.1990C>A	c.(1990-1992)Cca>Aca	p.P664T	COL19A1_ENST00000393344.1_Missense_Mutation_p.P286T	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	664	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TCAGGGAGTTCCAGGGAGAGA	0.483													42	83					8.20599e-20	1.12023e-19	1	1	0	A	70859890	C	A	70859890	3	1	48	1	0	0	0	0	1	0	0	0	3699	855	30	2	2104	2	COL19A1	6	70859890	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	473771	70859890	100255177	1706	6100										
COL9A1	1297	broad.mit.edu	37	chr6	71004214	71004214	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagagtgcttccagtcattcGaaacgtcgtcaagaaggagt	12	8	2	2	rs147237457		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:71004214G>A	ENST00000357250.6	-	5	510	c.352C>T	c.(352-354)Cga>Tga	p.R118*	COL9A1_ENST00000370496.3_Nonsense_Mutation_p.R118*	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	118	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CCAGTCATTCGAAACGTCGTC	0.403													34	53					0	0	1	0	0	A	71004214	G	A	71004214	4	1	48	1	0	0	0	0	0	1	0	0	3730	1066	37	1	2625	1	COL9A1	6	71004214	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	144324	71004214	100110853	1707	6101										
FAM135A	57579	broad.mit.edu	37	chr6	71233777	71233777	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attagatggagatctcaattCattacctataatctttgaag	6	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:71233777C>A	ENST00000418814.2	+	14	1825	c.1211C>A	c.(1210-1212)tCa>tAa	p.S404*	FAM135A_ENST00000370479.3_Nonsense_Mutation_p.S387*|FAM135A_ENST00000361499.3_Nonsense_Mutation_p.S404*|FAM135A_ENST00000505868.1_Nonsense_Mutation_p.S404*|FAM135A_ENST00000505769.1_Nonsense_Mutation_p.S404*|FAM135A_ENST00000457062.2_Nonsense_Mutation_p.S387*	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	404										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						GATCTCAATTCATTACCTATA	0.328													9	12					0.000274275	0.000292037	1	1	0	A	71233777	C	A	71233777	4	1	48	1	0	0	0	0	0	1	0	0	5479	838	29	2	1335	2	FAM135A	6	71233777	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	229563	71233777	99881290	1708	6102										
FAM135A	57579	broad.mit.edu	37	chr6	71235797	71235797	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaaaatagtgatgtattaAatctcacacagatgtattca	5	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:71235797A>C	ENST00000418814.2	+	15	3624	c.3010A>C	c.(3010-3012)Aat>Cat	p.N1004H	FAM135A_ENST00000370479.3_Missense_Mutation_p.N791H|FAM135A_ENST00000361499.3_Missense_Mutation_p.N808H|FAM135A_ENST00000505868.1_Missense_Mutation_p.N1004H|FAM135A_ENST00000505769.1_Missense_Mutation_p.N584H|FAM135A_ENST00000457062.2_Missense_Mutation_p.N791H	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	1004										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						TGATGTATTAAATCTCACACA	0.348													18	16					0	0	1	0	0	C	71235797	A	C	71235797	3	2	48	1	0	0	0	0	1	0	0	0	5479	14	1	4	3138	4	FAM135A	6	71235797	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2020	71235797	99879270	1709	6103										
FAM135A	57579	broad.mit.edu	37	chr6	71245997	71245997	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgttgggcaatttaataattCgttcagtgcttacaaggcca	9	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:71245997C>T	ENST00000418814.2	+	19	4614	c.4000C>T	c.(4000-4002)Cgt>Tgt	p.R1334C	FAM135A_ENST00000370479.3_Missense_Mutation_p.R1121C|FAM135A_ENST00000361499.3_Missense_Mutation_p.R1138C|FAM135A_ENST00000505868.1_Missense_Mutation_p.R1334C|FAM135A_ENST00000505769.1_Missense_Mutation_p.R914C|FAM135A_ENST00000457062.2_Missense_Mutation_p.R1121C	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	1334										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						TTTAATAATTCGTTCAGTGCT	0.343													18	30					0	0	1	0	0	T	71245997	C	T	71245997	3	4	48	1	0	0	0	0	1	0	0	0	5479	884	31	1	4144	1	FAM135A	6	71245997	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10200	71245997	99869070	1710	6104										
RIMS1	0	broad.mit.edu	37	chr6	72806813	72806813	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatctctgctcctattgtcGcactaagttctgtgcgcgct	8	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:72806813G>A	ENST00000264839.7	+	3	407	c.407G>A	c.(406-408)cGc>cAc	p.R136H	RIMS1_ENST00000522291.1_Missense_Mutation_p.R136H|RIMS1_ENST00000521978.1_Missense_Mutation_p.R136H|RIMS1_ENST00000518273.1_Missense_Mutation_p.R136H|RIMS1_ENST00000491071.2_Missense_Mutation_p.R136H|RIMS1_ENST00000348717.5_Missense_Mutation_p.R136H|RIMS1_ENST00000517960.1_Missense_Mutation_p.R136H|RIMS1_ENST00000520567.1_Missense_Mutation_p.R136H			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	136	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.R136H(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TCCTATTGTCGCACTAAGTTC	0.507													14	25					0	0	1	0	0	A	72806813	G	A	72806813	3	1	48	1	0	0	0	0	1	0	0	0	13418	1087	38	1	417	1	RIMS1	6	72806813	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1560816	72806813	98308254	1711	6105										
RIMS1	0	broad.mit.edu	37	chr6	72945357	72945357	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccatctaaagagggggacCgattaattggacgtgttatt	11	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:72945357C>T	ENST00000264839.7	+	8	1783	c.1783C>T	c.(1783-1785)Cga>Tga	p.R595*	RIMS1_ENST00000522291.1_Nonsense_Mutation_p.R595*|RIMS1_ENST00000521978.1_Nonsense_Mutation_p.R595*|RIMS1_ENST00000517827.1_Nonsense_Mutation_p.R54*|RIMS1_ENST00000518273.1_Nonsense_Mutation_p.R595*|RIMS1_ENST00000425662.2_5'UTR|RIMS1_ENST00000491071.2_Nonsense_Mutation_p.R595*|RIMS1_ENST00000348717.5_Nonsense_Mutation_p.R595*|RIMS1_ENST00000517960.1_Nonsense_Mutation_p.R595*|RIMS1_ENST00000520567.1_Nonsense_Mutation_p.R595*|RIMS1_ENST00000401910.3_Nonsense_Mutation_p.R69*|RIMS1_ENST00000523963.1_Nonsense_Mutation_p.R69*			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	595					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGAGGGGGACCGATTAATTGG	0.368													3	18					0	0	1	0	0	T	72945357	C	T	72945357	4	4	48	1	0	0	0	0	0	1	0	0	13418	644	23	1	1976	1	RIMS1	6	72945357	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	138544	72945357	98169710	1712	6106										
KCNQ5	56479	broad.mit.edu	37	chr6	73834249	73834249	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagcaggtttgtgatttctCtcttgctacatgtttgttta	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:73834249C>A	ENST00000370392.1	+	9	1345	c.1261C>A	c.(1261-1263)Ctc>Atc	p.L421I	KCNQ5_ENST00000355635.3_Intron|KCNQ5_ENST00000355194.4_Intron|KCNQ5_ENST00000342056.2_Intron|KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000403813.2_Intron|KCNQ5_ENST00000402622.2_Intron|KCNQ5_ENST00000370398.1_Intron			Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	0					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TGTGATTTCTCTCTTGCTACA	0.363													18	24					1.56452e-12	1.97515e-12	1	1	0	A	73834249	C	A	73834249	3	1	48	1	0	0	0	0	1	0	0	0	8129	928	32	2		2	KCNQ5	6	73834249	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	888892	73834249	97280818	1713	6107										
DDX43	55510	broad.mit.edu	37	chr6	74124304	74124304	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actaattgcaactgatctagCctctagaggacttgatgtcc	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:74124304C>T	ENST00000370336.4	+	14	1798	c.1640C>T	c.(1639-1641)gCc>gTc	p.A547V	MB21D1_ENST00000370318.1_Intron	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	547	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						ACTGATCTAGCCTCTAGAGGA	0.383													31	45					0	0	1	0	0	T	74124304	C	T	74124304	3	4	48	1	0	0	0	0	1	0	0	0	4386	739	26	3	1694	3	DDX43	6	74124304	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	290055	74124304	96990763	1714	6108										
SLC17A5	26503	broad.mit.edu	37	chr6	74325059	74325059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tataaggctaaaaattctgcGaacacataaagttgaaaaat	6	5	1	1	rs150686745		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:74325059G>A	ENST00000355773.5	-	8	1358	c.1090C>T	c.(1090-1092)Cgc>Tgc	p.R364C	SLC17A5_ENST00000393019.3_3'UTR	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	364					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity	p.R364C(3)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AAAATTCTGCGAACACATAAA	0.343													21	31					0	0	1	0	0	A	74325059	G	A	74325059	3	1	48	1	0	0	0	0	1	0	0	0	14474	1058	37	1	413	1	SLC17A5	6	74325059	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	200755	74325059	96790008	1715	6109										
CD109	135228	broad.mit.edu	37	chr6	74472181	74472181	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccttttggggaaagaagaAaaatattacaaaaacattta	6	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:74472181A>G	ENST00000437994.2	+	8	1264	c.833A>G	c.(832-834)aAa>aGa	p.K278R	CD109_ENST00000422508.2_Missense_Mutation_p.K201R|CD109_ENST00000287097.5_Missense_Mutation_p.K278R	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	278						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGAAAGAAGAAAAATATTACA	0.289													11	17					0	0	1	0	0	G	74472181	A	G	74472181	3	3	48	1	0	0	0	0	1	0	0	0	2985	14	1	4	863	4	CD109	6	74472181	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	147122	74472181	96642886	1716	6110										
FILIP1	27145	broad.mit.edu	37	chr6	76023417	76023417	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttttagcttcttccaaccGaaatctgtgtctcagttcag	6	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:76023417G>A	ENST00000393004.2	-	5	2352	c.2131C>T	c.(2131-2133)Cgg>Tgg	p.R711W	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000370020.1_Missense_Mutation_p.R612W|FILIP1_ENST00000237172.7_Missense_Mutation_p.R711W			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	711								p.R711W(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCTTCCAACCGAAATCTGTGT	0.413													28	123					0	0	1	0	0	A	76023417	G	A	76023417	3	1	48	1	0	0	0	0	1	0	0	0	5926	1057	37	1	1518	1	FILIP1	6	76023417	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1551236	76023417	95091650	1717	6111										
IMPG1	3617	broad.mit.edu	37	chr6	76728558	76728558	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctgctcctccaacacagcGaattctgtttctctttcctg	5	15	3	0	rs142510377	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:76728558G>A	ENST00000369950.3	-	7	873	c.684C>T	c.(682-684)ttC>ttT	p.F228F	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	228					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCAACACAGCGAATTCTGTTT	0.413													11	27					0	0	1	0	0	A	76728558	G	A	76728558	2	1	48	1	0	0	0	0	0	0	0	1	7771	1049	37	1		1	IMPG1	6	76728558	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	705141	76728558	94386509	1718	6112										
HTR1B	3351	broad.mit.edu	37	chr6	78172516	78172516	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtagaggatgtggtcggtgTtcaccacgcattccgacacc	12	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:78172516T>C	ENST00000369947.2	-	1	974	c.605A>G	c.(604-606)aAc>aGc	p.N202S		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	202					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GTGGTCGGTGTTCACCACGCA	0.587													7	34					0	0	1	0	0	C	78172516	T	C	78172516	3	2	48	1	0	0	0	0	1	0	0	0	7480	1725	60	4	571	4	HTR1B	6	78172516	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1443958	78172516	92942551	1719	6113										
HTR1B	3351	broad.mit.edu	37	chr6	78172749	78172749	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatgtccgacgacagccaGaagtcacagaccacctggcc	11	14	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:78172749G>T	ENST00000369947.2	-	1	741	c.372C>A	c.(370-372)ttC>ttA	p.F124L		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	124			F -> C (in dbSNP:rs130060).		G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	ACGACAGCCAGAAGTCACAGA	0.612													33	76					4.11147e-13	5.25189e-13	1	1	0	T	78172749	G	T	78172749	3	4	48	1	0	0	0	0	1	0	0	0	7480	933	33	2	804	2	HTR1B	6	78172749	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	233	78172749	92942318	1720	6114										
PHIP	55023	broad.mit.edu	37	chr6	79650668	79650668	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggttacttctccttaacacTttgacacttgcagggactag	8	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:79650668T>G	ENST00000275034.4	-	40	5375	c.5208A>C	c.(5206-5208)aaA>aaC	p.K1736N	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1736					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TCCTTAACACTTTGACACTTG	0.393													26	67					0	0	1	0	0	G	79650668	T	G	79650668	3	3	48	1	0	0	0	0	1	0	0	0	11889	1606	56	4	261	4	PHIP	6	79650668	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1477919	79650668	91464399	1721	6115										
PHIP	55023	broad.mit.edu	37	chr6	79657392	79657392	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattactgaaaataagtctgAcatctttacataactccatt	3	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:79657392A>G	ENST00000275034.4	-	36	4321	c.4154T>C	c.(4153-4155)gTc>gCc	p.V1385A	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1385	Bromo 2.				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		AATAAGTCTGACATCTTTACA	0.343													10	34					0	0	1	0	0	G	79657392	A	G	79657392	3	3	48	1	0	0	0	0	1	0	0	0	11889	275	10	4	1331	4	PHIP	6	79657392	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6724	79657392	91457675	1722	6116										
TTK	7272	broad.mit.edu	37	chr6	80717701	80717701	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccccagataaatatggccaAaatgagagttttgctagaat	8	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:80717701A>C	ENST00000509894.1	+	3	1144	c.315A>C	c.(313-315)caA>caC	p.Q105H	TTK_ENST00000230510.3_Missense_Mutation_p.Q105H|TTK_ENST00000369798.2_Missense_Mutation_p.Q105H			P33981	TTK_HUMAN	TTK protein kinase	105					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AATATGGCCAAAATGAGAGTT	0.333													21	34					0	0	1	0	0	C	80717701	A	C	80717701	3	2	48	1	0	0	0	0	1	0	0	0	16781	11	1	4	321	4	TTK	6	80717701	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1060309	80717701	90397366	1723	6117										
TTK	7272	broad.mit.edu	37	chr6	80737720	80737720	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttgccactccacttcaaAatttacaggttcgataagct	5	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:80737720A>C	ENST00000509894.1	+	13	2339	c.1510A>C	c.(1510-1512)Aat>Cat	p.N504H	TTK_ENST00000230510.3_Missense_Mutation_p.N504H|TTK_ENST00000369798.2_Missense_Mutation_p.N505H			P33981	TTK_HUMAN	TTK protein kinase	505					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TCCACTTCAAAATTTACAGGT	0.373													12	35					0	0	1	0	0	C	80737720	A	C	80737720	3	2	48	1	0	0	0	0	1	0	0	0	16781	14	1	4	1559	4	TTK	6	80737720	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	20019	80737720	90377347	1724	6118										
BCKDHB	594	broad.mit.edu	37	chr6	80912855	80912855	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtagcttccatggcaaaaGaaaagcttggagtgtcttgt	12	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:80912855G>T	ENST00000320393.6	+	8	924	c.877G>T	c.(877-879)Gaa>Taa	p.E293*	BCKDHB_ENST00000545529.1_3'UTR|BCKDHB_ENST00000356489.5_Nonsense_Mutation_p.E293*	NM_183050.2	NP_898871.1	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	293					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		CATGGCAAAAGAAAAGCTTGG	0.373													31	49					1.26612e-14	1.65413e-14	1	1	0	T	80912855	G	T	80912855	4	4	48	1	0	0	0	0	0	1	0	0	1358	943	33	2	907	2	BCKDHB	6	80912855	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	175135	80912855	90202212	1725	6119										
DOPEY1	23033	broad.mit.edu	37	chr6	83848209	83848209	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagatttaataggcaatcGaaacatgcaaatgatgagca	8	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:83848209G>A	ENST00000349129.2	+	21	4708	c.4448G>A	c.(4447-4449)cGa>cAa	p.R1483Q	DOPEY1_ENST00000369739.3_Missense_Mutation_p.R1474Q|DOPEY1_ENST00000237163.5_Missense_Mutation_p.R1464Q|DOPEY1_ENST00000484282.1_3'UTR	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1483					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ATAGGCAATCGAAACATGCAA	0.368													19	35					0	0	1	0	0	A	83848209	G	A	83848209	3	1	48	1	0	0	0	0	1	0	0	0	4734	1058	37	1	4522	1	DOPEY1	6	83848209	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2935354	83848209	87266858	1726	6120										
SNAP91	9892	broad.mit.edu	37	chr6	84302200	84302200	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaggtctatgacacctgaaGaatccacctttgctggcgag	10	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:84302200G>T	ENST00000428679.2	-	21	2497	c.1904C>A	c.(1903-1905)tCt>tAt	p.S635Y	SNAP91_ENST00000521743.1_Missense_Mutation_p.S635Y|SNAP91_ENST00000437520.1_Intron|SNAP91_ENST00000520213.1_Intron|SNAP91_ENST00000520302.1_Intron|SNAP91_ENST00000521485.1_Missense_Mutation_p.S635Y|SNAP91_ENST00000195649.6_Missense_Mutation_p.S635Y|SNAP91_ENST00000439399.2_Missense_Mutation_p.S635Y|SNAP91_ENST00000369694.2_Missense_Mutation_p.S635Y			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	635					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GACACCTGAAGAATCCACCTT	0.423													6	13					2.7689e-08	3.25926e-08	1	1	0	T	84302200	G	T	84302200	3	4	48	1	0	0	0	0	1	0	0	0	14886	942	33	2	855	2	SNAP91	6	84302200	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	453991	84302200	86812867	1727	6121										
CYB5R4	51167	broad.mit.edu	37	chr6	84649908	84649908	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atactgaattatgctttgacTgatatacccagtctcaggta	7	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:84649908T>G	ENST00000369681.4	+	13	1382	c.1242T>G	c.(1240-1242)acT>acG	p.T414T	CYB5R4_ENST00000479164.1_3'UTR	NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	414					cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		ATGCTTTGACTGATATACCCA	0.333													10	38					0	0	1	0	0	G	84649908	T	G	84649908	2	3	48	1	0	0	0	0	0	0	0	1	4152	1567	55	4		4	CYB5R4	6	84649908	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	347708	84649908	86465159	1728	6122										
KIAA1009	22832	broad.mit.edu	37	chr6	84859327	84859327	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcagctactttggaagaaGaattttctactgcattttgg	9	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:84859327G>T	ENST00000403245.3	-	24	3839	c.3725C>A	c.(3724-3726)tCt>tAt	p.S1242Y	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Missense_Mutation_p.S1166Y	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	1242					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding	p.S1242Y(1)		breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TTTGGAAGAAGAATTTTCTAC	0.363													17	29					0.000422831	0.000449533	1	1	0	T	84859327	G	T	84859327	3	4	48	1	0	0	0	0	1	0	0	0	8244	942	33	2	502	2	KIAA1009	6	84859327	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	209419	84859327	86255740	1729	6123										
ZNF292	23036	broad.mit.edu	37	chr6	87967813	87967813	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtcaagaaggtagtgaaaTtattaaacaggctttggaaa	10	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:87967813T>G	ENST00000369577.3	+	8	4509	c.4466T>G	c.(4465-4467)aTt>aGt	p.I1489S	ZNF292_ENST00000339907.4_Missense_Mutation_p.I1484S	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GGTAGTGAAATTATTAAACAG	0.413													10	22					0	0	1	0	0	G	87967813	T	G	87967813	3	3	48	1	0	0	0	0	1	0	0	0	17882	1493	52	4	4496	4	ZNF292	6	87967813	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3108486	87967813	83147254	1730	6124										
ZNF292	23036	broad.mit.edu	37	chr6	87969514	87969514	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgacaaaacagaaagttCtttacaagtgattacagtta	6	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:87969514C>T	ENST00000369577.3	+	8	6210	c.6167C>T	c.(6166-6168)tCt>tTt	p.S2056F	ZNF292_ENST00000339907.4_Missense_Mutation_p.S2051F	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2056					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACAGAAAGTTCTTTACAAGTG	0.353													9	16					0	0	1	0	0	T	87969514	C	T	87969514	3	4	48	1	0	0	0	0	1	0	0	0	17882	913	32	3	6197	3	ZNF292	6	87969514	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1701	87969514	83145553	1731	6125										
CASP8AP2	9994	broad.mit.edu	37	chr6	90572627	90572627	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagaatgaaataacattttCtcataattcaagtaaatacc	3	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:90572627C>A	ENST00000551025.1	+	0	2636							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		ATAACATTTTCTCATAATTCA	0.348													8	61					0.00307968	0.00320271	1	1	0	A	90572627	C	A	90572627	1	1	48	0	1	0	0	0	0	0	0	0	2696	913	32	2		2	CASP8AP2	6	90572627	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2603113	90572627	80542440	1732	6126										
CASP8AP2	9994	broad.mit.edu	37	chr6	90578240	90578240	+	RNA	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgatttgacacaagatgCttcaagtgaggctaaaagtg	10	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:90578240C>A	ENST00000551025.1	+	0	6668							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		ACACAAGATGCTTCAAGTGAG	0.393													11	21					1.58986e-06	1.78832e-06	1	1	0	A	90578240	C	A	90578240	1	1	48	0	1	0	0	0	0	0	0	0	2696	797	28	5		5	CASP8AP2	6	90578240	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5613	90578240	80536827	1733	6127										
GJA10	84694	broad.mit.edu	37	chr6	90605648	90605648	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaagacaggcagccctaccGatcatggaactatcacaaga	9	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:90605648G>A	ENST00000369352.1	+	1	1461	c.1461G>A	c.(1459-1461)ccG>ccA	p.P487P		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	487					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CAGCCCTACCGATCATGGAAC	0.478													39	76					0	0	1	0	0	A	90605648	G	A	90605648	2	1	48	1	0	0	0	0	0	0	0	1	6442	1045	37	1		1	GJA10	6	90605648	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	27408	90605648	80509419	1734	6128										
FUT9	10690	broad.mit.edu	37	chr6	96651946	96651946	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaaagtatctgaaggaagtCgacaaaaacaataagttata	8	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:96651946C>T	ENST00000302103.5	+	3	1241	c.915C>T	c.(913-915)gtC>gtT	p.V305V		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	305					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TGAAGGAAGTCGACAAAAACA	0.373													5	36					0	0	1	0	0	T	96651946	C	T	96651946	2	4	48	1	0	0	0	0	0	0	0	1	6145	871	31	1		1	FUT9	6	96651946	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6046298	96651946	74463121	1735	6129										
GPR63	0	broad.mit.edu	37	chr6	97246800	97246800	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatcctcaaggcattgtgccGaagggtgttgagtatgccca	13	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:97246800G>A	ENST00000229955.3	-	2	1153	c.808C>T	c.(808-810)Cgg>Tgg	p.R270W	GPR63_ENST00000417980.1_Missense_Mutation_p.R270W	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	270						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GCATTGTGCCGAAGGGTGTTG	0.468													38	83					0	0	1	0	0	A	97246800	G	A	97246800	3	1	48	1	0	0	0	0	1	0	0	0	6743	1057	37	1	455	1	GPR63	6	97246800	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	594854	97246800	73868267	1736	6130										
FBXL4	26235	broad.mit.edu	37	chr6	99323520	99323520	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctattccattctcagtaatAttcttacatctccacagatc	3	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:99323520A>C	ENST00000369244.2	-	9	1901	c.1473T>G	c.(1471-1473)aaT>aaG	p.N491K	FBXL4_ENST00000229971.1_Missense_Mutation_p.N491K			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	491					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		TCTCAGTAATATTCTTACATC	0.468													11	62					0	0	1	0	0	C	99323520	A	C	99323520	3	2	48	1	0	0	0	0	1	0	0	0	5753	446	16	4	400	4	FBXL4	6	99323520	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2076720	99323520	71791547	1737	6131										
PRDM13	59336	broad.mit.edu	37	chr6	100057121	100057121	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagctgacagtgtggtattCtaactccttggctcagtggt	13	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:100057121C>A	ENST00000369214.1	+	3	626	c.365C>A	c.(364-366)tCt>tAt	p.S122Y	PRDM13_ENST00000369215.4_Missense_Mutation_p.S112Y	NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		GTGTGGTATTCTAACTCCTTG	0.537													11	22					2.27111e-07	2.60515e-07	1	1	0	A	100057121	C	A	100057121	3	1	48	1	0	0	0	0	1	0	0	0	12505	913	32	2	345	2	PRDM13	6	100057121	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	733601	100057121	71057946	1738	6132										
MCHR2	84539	broad.mit.edu	37	chr6	100403957	100403957	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcagtttgataagcaaactCtttattccaggatttgttta	8	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:100403957C>A	ENST00000281806.2	-	2	381	c.67G>T	c.(67-69)Gag>Tag	p.E23*	MCHR2_ENST00000369212.1_Nonsense_Mutation_p.E23*|MCHR2_ENST00000445970.1_Nonsense_Mutation_p.E23*	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	23						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		TAAGCAAACTCTTTATTCCAG	0.423													31	69					3.11337e-16	4.1367e-16	1	1	0	A	100403957	C	A	100403957	4	1	48	1	0	0	0	0	0	1	0	0	9432	922	32	2	975	2	MCHR2	6	100403957	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	346836	100403957	70711110	1739	6133										
SIM1	6492	broad.mit.edu	37	chr6	100838345	100838345	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgagccattacagcccaaGgaatagtttctaatggtttc	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:100838345G>T	ENST00000369208.3	-	12	2975	c.2193C>A	c.(2191-2193)tcC>tcA	p.S731S	SIM1_ENST00000262901.4_Silent_p.S731S			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	731	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TACAGCCCAAGGAATAGTTTC	0.448													27	84					1.66031e-10	2.0393e-10	1	1	0	T	100838345	G	T	100838345	2	4	48	1	0	0	0	0	0	0	0	1	14377	987	35	5		5	SIM1	6	100838345	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	434388	100838345	70276722	1740	6134										
ASCC3	10973	broad.mit.edu	37	chr6	101248328	101248328	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttcagactgaatagtgacTtgacaaccataattgggttt	9	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:101248328T>G	ENST00000369162.2	-	6	1319	c.975A>C	c.(973-975)caA>caC	p.Q325H	ASCC3_ENST00000522650.1_Missense_Mutation_p.Q325H	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GAATAGTGACTTGACAACCAT	0.303													11	11					0	0	1	0	0	G	101248328	T	G	101248328	3	3	48	1	0	0	0	0	1	0	0	0	1032	1606	56	4	5781	4	ASCC3	6	101248328	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	409983	101248328	69866739	1741	6135										
PREP	5550	broad.mit.edu	37	chr6	105825262	105825262	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagtaaaagcagtctcaccGttttcctttcttgaagtggc	8	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:105825262G>A	ENST00000369110.3	-	3	445	c.254_splice	c.e3+1	p.R85_splice		NM_002726.4	NP_002717.3	P48147	PPCE_HUMAN	prolyl endopeptidase	85					proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	CAGTCTCACCGTTTTCCTTTC	0.328													27	66					0	0	1	0	0	A	105825262	G	A	105825262	5	1	48	1	0	0	0	0	0	0	1	0	12525	1159	40	1	1931	1	PREP	6	105825262	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4576934	105825262	65289805	1742	6136										
PRDM1	639	broad.mit.edu	37	chr6	106552805	106552805	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagaaatcctaaaattggActccaacccctccaaaggaa	6	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:106552805A>G	ENST00000369096.4	+	5	1004	c.770A>G	c.(769-771)gAc>gGc	p.D257G	PRDM1_ENST00000369089.3_Missense_Mutation_p.D123G|PRDM1_ENST00000369091.2_Missense_Mutation_p.D221G	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	257					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CTAAAATTGGACTCCAACCCC	0.468			"D, N, Mis, F, S"		DLBCL								10	390					0	0	1	0	0	G	106552805	A	G	106552805	3	3	48	1	0	0	0	0	1	0	0	0	12501	275	10	4	801	4	PRDM1	6	106552805	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	727543	106552805	64562262	1743	6137										
AIM1	202	broad.mit.edu	37	chr6	106968877	106968877	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgtgacatcagtcaacaCtatgaccacggctttcagta	7	11	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:106968877C>A	ENST00000369066.3	+	2	3057	c.2570C>A	c.(2569-2571)aCt>aAt	p.T857N		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	857							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TCAGTCAACACTATGACCACG	0.443													31	56					5.45727e-16	7.22369e-16	1	1	0	A	106968877	C	A	106968877	3	1	48	1	0	0	0	0	1	0	0	0	427	565	20	5	2576	5	AIM1	6	106968877	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	416072	106968877	64146190	1744	6138										
RTN4IP1	84816	broad.mit.edu	37	chr6	107019892	107019892	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaacaacattaattacagtCtttcctcgtgcgtgtcctct	5	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:107019892C>A	ENST00000369063.3	-	9	1635	c.1170G>T	c.(1168-1170)aaG>aaT	p.K390N	RTN4IP1_ENST00000498091.1_5'UTR|RTN4IP1_ENST00000539449.1_3'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	390						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		TAATTACAGTCTTTCCTCGTG	0.388													21	43					1.00905e-13	1.29777e-13	1	1	0	A	107019892	C	A	107019892	3	1	48	1	0	0	0	0	1	0	0	0	13780	912	32	2	24	2	RTN4IP1	6	107019892	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	51015	107019892	64095175	1745	6139										
SEC63	11231	broad.mit.edu	37	chr6	108204347	108204347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatcttcctttactgcagCttcctaaaagggaaaggcaa	7	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:108204347C>T	ENST00000369002.4	-	17	1857	c.1678G>A	c.(1678-1680)Gct>Act	p.A560T		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	560					protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TTTACTGCAGCTTCCTAAAAG	0.358													7	20					0	0	1	0	0	T	108204347	C	T	108204347	3	4	48	1	0	0	0	0	1	0	0	0	14058	797	28	3	624	3	SEC63	6	108204347	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1184455	108204347	62910720	1746	6140										
PPIL6	285755	broad.mit.edu	37	chr6	109752502	109752502	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaaactgaccattaacaAaagaaatcacagaggaagaa	7	8	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:109752502A>C	ENST00000521072.2	-	3	858	c.278T>G	c.(277-279)tTt>tGt	p.F93C	PPIL6_ENST00000440797.2_Missense_Mutation_p.F93C|PPIL6_ENST00000424445.2_Missense_Mutation_p.F61C|PPIL6_ENST00000524031.1_5'UTR	NM_173672.4	NP_775943.1	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 6	93					protein folding		peptidyl-prolyl cis-trans isomerase activity			large_intestine(3)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		ACCATTAACAAAAGAAATCAC	0.403													22	37					0	0	1	0	0	C	109752502	A	C	109752502	3	2	48	1	0	0	0	0	1	0	0	0	12379	14	1	4	763	4	PPIL6	6	109752502	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1548155	109752502	61362565	1747	6141										
MICAL1	64780	broad.mit.edu	37	chr6	109766179	109766179	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgtcctacccatagtttCttttgctgttctggggaacc	9	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:109766179C>A	ENST00000368952.4	-	23	3248	c.2958G>T	c.(2956-2958)aaG>aaT	p.K986N	MICAL1_ENST00000358577.3_Missense_Mutation_p.K881N|MICAL1_ENST00000358807.3_Missense_Mutation_p.K967N			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	967					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CCCATAGTTTCTTTTGCTGTT	0.542													26	87					8.24728e-16	1.09065e-15	1	1	0	A	109766179	C	A	109766179	3	1	48	1	0	0	0	0	1	0	0	0	9616	912	32	2	314	2	MICAL1	6	109766179	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13677	109766179	61348888	1748	6142										
ZBTB24	9841	broad.mit.edu	37	chr6	109788914	109788914	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgaaagatttgccacagaTttcacaagtaaatggcttct	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:109788914T>C	ENST00000230122.3	-	6	1479	c.1312A>G	c.(1312-1314)Atc>Gtc	p.I438V		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TTGCCACAGATTTCACAAGTA	0.333													7	36					0	0	1	0	0	C	109788914	T	C	109788914	3	2	48	1	0	0	0	0	1	0	0	0	17589	1493	52	4	789	4	ZBTB24	6	109788914	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	22735	109788914	61326153	1749	6143										
ZBTB24	9841	broad.mit.edu	37	chr6	109802552	109802552	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actggcatttcctcctctctActtggctcacaagtaggctc	7	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:109802552A>G	ENST00000230122.3	-	2	845	c.678T>C	c.(676-678)agT>agC	p.S226S		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		CCTCCTCTCTACTTGGCTCAC	0.453													67	117					0	0	1	0	0	G	109802552	A	G	109802552	2	3	48	1	0	0	0	0	0	0	0	1	17589	388	14	4		4	ZBTB24	6	109802552	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	13638	109802552	61312515	1750	6144										
ZBTB24	9841	broad.mit.edu	37	chr6	109802872	109802872	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgtaagcctttaccaggtCatagacttttaagaactgag	9	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:109802872C>A	ENST00000230122.3	-	2	525	c.358G>T	c.(358-360)Gac>Tac	p.D120Y		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	120	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TTTACCAGGTCATAGACTTTT	0.418													40	72					5.04308e-16	6.68172e-16	1	1	0	A	109802872	C	A	109802872	3	1	48	1	0	0	0	0	1	0	0	0	17589	826	29	2	1809	2	ZBTB24	6	109802872	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	320	109802872	61312195	1751	6145										
FIG4	9896	broad.mit.edu	37	chr6	110062741	110062741	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcttaaaagaggtgcaaaCtgtgaggtaagatgacaaac	10	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:110062741C>A	ENST00000230124.3	+	8	994	c.870C>A	c.(868-870)aaC>aaA	p.N290K	FIG4_ENST00000368941.1_Intron|FIG4_ENST00000441478.2_Intron	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	290	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GAGGTGCAAACTGTGAGGTAA	0.383													30	44					7.26314e-15	9.49782e-15	1	1	0	A	110062741	C	A	110062741	3	1	48	1	0	0	0	0	1	0	0	0	5920	564	20	5	900	5	FIG4	6	110062741	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	259869	110062741	61052326	1752	6146										
WASF1	8936	broad.mit.edu	37	chr6	110423417	110423417	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctatcaaacctgtagcaGaactgaaatgacaaagagat	7	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:110423417G>T	ENST00000392589.1	-	10	1732	c.896C>A	c.(895-897)tCt>tAt	p.S299Y	WASF1_ENST00000392587.2_Missense_Mutation_p.S299Y|WASF1_ENST00000392588.1_Missense_Mutation_p.S299Y|WASF1_ENST00000359451.2_Missense_Mutation_p.S299Y|WASF1_ENST00000392586.1_Missense_Mutation_p.S299Y	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	299					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		ACCTGTAGCAGAACTGAAATG	0.418													36	68					7.04047e-22	9.7605e-22	1	1	0	T	110423417	G	T	110423417	3	4	48	1	0	0	0	0	1	0	0	0	17311	942	33	2	791	2	WASF1	6	110423417	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	360676	110423417	60691650	1753	6147										
CDK19	23097	broad.mit.edu	37	chr6	110988687	110988687	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggtaatggataccatcaaGaatctggtaaagtaaggatt	11	4	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:110988687G>A	ENST00000368911.3	-	4	585	c.406C>T	c.(406-408)Ctt>Ttt	p.L136F	CDK19_ENST00000323817.3_Missense_Mutation_p.L76F	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	136	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						ATACCATCAAGAATCTGGTAA	0.328													20	29					0	0	1	0	0	A	110988687	G	A	110988687	3	1	48	1	0	0	0	0	1	0	0	0	3157	942	33	3	1142	3	CDK19	6	110988687	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	565270	110988687	60126380	1754	6148										
SLC16A10	117247	broad.mit.edu	37	chr6	111540115	111540115	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcctcatcatgggtctcttCgatggatgcttcatttccat	8	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:111540115C>T	ENST00000368850.3	+	4	729	c.243C>T	c.(241-243)ttC>ttT	p.F81F	SLC16A10_ENST00000368851.5_Silent_p.F395F			Q8TF71	MOT10_HUMAN	solute carrier family 16 (aromatic amino acid transporter), member 10	395					aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)	12		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		TGGGTCTCTTCGATGGATGCT	0.468													39	77					0	0	1	0	0	T	111540115	C	T	111540115	2	4	48	1	0	0	0	0	0	0	0	1	14457	883	31	1		1	SLC16A10	6	111540115	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	551428	111540115	59574952	1755	6149										
REV3L	5980	broad.mit.edu	37	chr6	111680169	111680169	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggatccggttctaagtctcGtctagttcgagcatgcaact	10	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:111680169G>A	ENST00000435970.1	-	19	7510	c.6694C>T	c.(6694-6696)Cga>Tga	p.R2232*	REV3L_ENST00000368802.3_Nonsense_Mutation_p.R2310*|REV3L_ENST00000358835.3_Nonsense_Mutation_p.R2310*|REV3L_ENST00000368805.1_Nonsense_Mutation_p.R2310*			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2310					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCTAAGTCTCGTCTAGTTCGA	0.373								DNA polymerases (catalytic subunits)					20	39					0	0	1	0	0	A	111680169	G	A	111680169	4	1	48	1	0	0	0	0	0	1	0	0	13291	1153	40	1	2528	1	REV3L	6	111680169	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	140054	111680169	59434898	1756	6150										
REV3L	5980	broad.mit.edu	37	chr6	111693940	111693940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttcagaatgttagcagttCgaggggtgaagctgccattt	13	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:111693940C>T	ENST00000435970.1	-	15	6200	c.5384G>A	c.(5383-5385)cGa>cAa	p.R1795Q	REV3L_ENST00000368802.3_Missense_Mutation_p.R1873Q|REV3L_ENST00000358835.3_Missense_Mutation_p.R1873Q|REV3L_ENST00000368805.1_Missense_Mutation_p.R1873Q			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1873					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding	p.R1795Q(1)		NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTTAGCAGTTCGAGGGGTGAA	0.413								DNA polymerases (catalytic subunits)					55	131					0	0	1	0	0	T	111693940	C	T	111693940	3	4	48	1	0	0	0	0	1	0	0	0	13291	884	31	1	3854	1	REV3L	6	111693940	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13771	111693940	59421127	1757	6151										
FYN	2534	broad.mit.edu	37	chr6	111983095	111983095	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagatggggcagtcctgcggGcagggcatcctgtagcctcg	17	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:111983095G>A	ENST00000354650.3	-	14	2067	c.1461C>T	c.(1459-1461)tgC>tgT	p.C487C	FYN_ENST00000368667.2_Silent_p.C487C|FYN_ENST00000356013.2_Silent_p.C432C|FYN_ENST00000229471.4_Silent_p.C432C|FYN_ENST00000368682.3_Silent_p.C484C|FYN_ENST00000538466.1_Silent_p.C484C|FYN_ENST00000368678.4_Silent_p.C484C|FYN_ENST00000229470.5_Silent_p.C435C	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	487	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	AGTCCTGCGGGCAGGGCATCC	0.597													43	86					0	0	1	0	0	A	111983095	G	A	111983095	2	1	48	1	0	0	0	0	0	0	0	1	6160	1195	42	3		3	FYN	6	111983095	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	289155	111983095	59131972	1758	6152										
FYN	2534	broad.mit.edu	37	chr6	112020831	112020831	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtttgtggggtacaactcGatgcaatcacagttaagtta	10	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:112020831G>A	ENST00000368682.3	-	9	961	c.740C>T	c.(739-741)tCg>tTg	p.S247L	FYN_ENST00000368667.2_Intron|FYN_ENST00000356013.2_Intron|FYN_ENST00000229471.4_Intron|FYN_ENST00000538466.1_Missense_Mutation_p.S247L|FYN_ENST00000354650.3_Intron|FYN_ENST00000368678.4_Missense_Mutation_p.S247L|FYN_ENST00000229470.5_Missense_Mutation_p.S198L|FYN_ENST00000476769.2_Intron			P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	247					axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGTACAACTCGATGCAATCAC	0.418													21	51					0	0	1	0	0	A	112020831	G	A	112020831	3	1	48	1	0	0	0	0	1	0	0	0	6160	1059	37	1	888	1	FYN	6	112020831	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37736	112020831	59094236	1759	6153										
LAMA4	3910	broad.mit.edu	37	chr6	112476055	112476055	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagtgaagatatttactaGactctgcctttgcttgcagt	9	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:112476055G>T	ENST00000230538.7	-	16	2451	c.2054C>A	c.(2053-2055)tCt>tAt	p.S685Y	RP1-142L7.5_ENST00000425503.1_RNA|LAMA4_ENST00000389463.4_Missense_Mutation_p.S678Y|LAMA4_ENST00000424408.2_Missense_Mutation_p.S678Y|LAMA4_ENST00000522006.1_Missense_Mutation_p.S678Y|RP1-142L7.5_ENST00000585373.1_RNA|RP1-142L7.5_ENST00000588689.1_RNA	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	685	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ATATTTACTAGACTCTGCCTT	0.383													17	38					5.01169e-05	5.45927e-05	1	1	0	T	112476055	G	T	112476055	3	4	48	1	0	0	0	0	1	0	0	0	8646	942	33	2	3513	2	LAMA4	6	112476055	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	455224	112476055	58639012	1760	6154										
RFPL4B	442247	broad.mit.edu	37	chr6	112671559	112671559	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctggatgctgacttagaaGaaatccagttttttgatgtt	9	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:112671559G>T	ENST00000441065.2	+	3	961	c.649G>T	c.(649-651)Gaa>Taa	p.E217*		NM_001013734.2	NP_001013756.2	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	217	B30.2/SPRY.						zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	14		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		TGACTTAGAAGAAATCCAGTT	0.448													25	33					6.32553e-13	8.04352e-13	1	1	0	T	112671559	G	T	112671559	4	4	48	1	0	0	0	0	0	1	0	0	13307	943	33	2	651	2	RFPL4B	6	112671559	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	195504	112671559	58443508	1761	6155										
HDAC2	3066	broad.mit.edu	37	chr6	114264533	114264533	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctgtttttttgtcctctgTttctttcttatcttcttcaa	3	10	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:114264533T>C	ENST00000519065.1	-	12	1736	c.1360A>G	c.(1360-1362)Aca>Gca	p.T454A	HDAC2_ENST00000398283.2_Missense_Mutation_p.T548A|HDAC2_ENST00000519108.1_Missense_Mutation_p.T424A|HDAC2_ENST00000368632.2_Missense_Mutation_p.T424A			Q92769	HDAC2_HUMAN	histone deacetylase 2	454					blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	ttgtcctctgtttctttctta	0.333													3	36					0	0	1	0	0	C	114264533	T	C	114264533	3	2	48	1	0	0	0	0	1	0	0	0	7047	1725	60	4	118	4	HDAC2	6	114264533	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1592974	114264533	56850534	1762	6156										
DSE	29940	broad.mit.edu	37	chr6	116758182	116758182	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagaaagaactacccataGatgaagatgaagaaatgaaa	8	6	0	8			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:116758182G>T	ENST00000331677.3	+	7	2995	c.2551G>T	c.(2551-2553)Gat>Tat	p.D851Y	DSE_ENST00000537543.1_Missense_Mutation_p.D870Y|DSE_ENST00000359564.2_Missense_Mutation_p.D851Y|DSE_ENST00000452085.3_Missense_Mutation_p.D851Y			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	851					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		ACTACCCATAGATGAAGATGA	0.383													18	40					2.48551e-13	3.17925e-13	1	1	0	T	116758182	G	T	116758182	3	4	48	1	0	0	0	0	1	0	0	0	4800	942	33	2	2569	2	DSE	6	116758182	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2493649	116758182	54356885	1763	6157										
RSPH4A	345895	broad.mit.edu	37	chr6	116949485	116949485	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaagtgattgatctagtaGaatccctatccaattgggtt	8	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:116949485G>T	ENST00000229554.5	+	3	1752	c.1615G>T	c.(1615-1617)Gaa>Taa	p.E539*	RSPH4A_ENST00000368580.4_Intron|RSPH4A_ENST00000368581.4_Nonsense_Mutation_p.E539*	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	539	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TGATCTAGTAGAATCCCTATC	0.423									Kartagener syndrome				28	69					2.47511e-08	2.91589e-08	1	1	0	T	116949485	G	T	116949485	4	4	48	1	0	0	0	0	0	1	0	0	13757	943	33	2	1625	2	RSPH4A	6	116949485	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	191303	116949485	54165582	1764	6158										
ROS1	6098	broad.mit.edu	37	chr6	117609891	117609891	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccatatagtttaacccttCtcggttcttcgtttccatta	4	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:117609891C>A	ENST00000368508.3	-	43	7006	c.6808G>T	c.(6808-6810)Gaa>Taa	p.E2270*	ROS1_ENST00000368507.3_Nonsense_Mutation_p.E2264*	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2270					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.E2270K(2)	TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTTAACCCTTCTCGGTTCTTC	0.408			T	"GOPC, SDC4, SLC34A2, EZR, LRIG3"	"glioblastoma, NSCLC"								20	27					1.33834e-09	1.61283e-09	1	1	0	A	117609891	C	A	117609891	4	1	48	1	0	0	0	0	0	1	0	0	13582	922	32	2	239	2	ROS1	6	117609891	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	660406	117609891	53505176	1765	6159										
ROS1	6098	broad.mit.edu	37	chr6	117715350	117715350	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catccatgatgaaatacattCtttgataaagccaatctatg	5	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:117715350C>A	ENST00000368508.3	-	10	1337	c.1139G>T	c.(1138-1140)aGa>aTa	p.R380I	ROS1_ENST00000368507.3_Missense_Mutation_p.R389I|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	380					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R380I(2)	TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GAAATACATTCTTTGATAAAG	0.353			T	"GOPC, SDC4, SLC34A2, EZR, LRIG3"	"glioblastoma, NSCLC"								5	12					0.000602214	0.000636035	1	1	0	A	117715350	C	A	117715350	3	1	48	1	0	0	0	0	1	0	0	0	13582	913	32	2	6040	2	ROS1	6	117715350	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	105459	117715350	53399717	1766	6160										
SLC35F1	222553	broad.mit.edu	37	chr6	118228913	118228913	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcccccctgagcagccgcaGcagcagctgcagccgccgtc	11	19	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:118228913G>A	ENST00000360388.4	+	1	225	c.24G>A	c.(22-24)caG>caA	p.Q8Q		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	8					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		AGCAGCCGCAGCAGCAGCTGC	0.741													12	11					0	0	1	0	0	A	118228913	G	A	118228913	2	1	48	1	0	0	0	0	0	0	0	1	14642	962	34	3		3	SLC35F1	6	118228913	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	513563	118228913	52886154	1767	6161										
SLC35F1	222553	broad.mit.edu	37	chr6	118475689	118475689	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgactagcaagtatctgtcAgaagatttccacgccaacac	7	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:118475689A>G	ENST00000360388.4	+	2	456	c.255A>G	c.(253-255)tcA>tcG	p.S85S		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	85					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		AGTATCTGTCAGAAGATTTCC	0.443													9	141					0	0	1	0	0	G	118475689	A	G	118475689	2	3	48	1	0	0	0	0	0	0	0	1	14642	175	7	4		4	SLC35F1	6	118475689	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	246776	118475689	52639378	1768	6162										
SLC35F1	222553	broad.mit.edu	37	chr6	118556698	118556698	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaacctcctggcaattttaCgacgaagatggtggaagtac	10	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:118556698C>T	ENST00000360388.4	+	3	577	c.376C>T	c.(376-378)Cga>Tga	p.R126*		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	126					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		GGCAATTTTACGACGAAGATG	0.378													9	30					0	0	1	0	0	T	118556698	C	T	118556698	4	4	48	1	0	0	0	0	0	1	0	0	14642	528	19	1	386	1	SLC35F1	6	118556698	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	81009	118556698	52558369	1769	6163										
ASF1A	25842	broad.mit.edu	37	chr6	119226904	119226904	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgtacctatcgaggacaaGaatttattagagttggctat	9	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:119226904G>T	ENST00000229595.5	+	3	507	c.313G>T	c.(313-315)Gaa>Taa	p.E105*	MCM9_ENST00000316316.6_Intron	NM_014034.2	NP_054753.1	Q9Y294	ASF1A_HUMAN	anti-silencing function 1A histone chaperone	105	Interaction with histone H3, CHAF1B, and HIRA.				chromatin modification|DNA repair|loss of chromatin silencing|nucleosome assembly|transcription, DNA-dependent	chromatin remodeling complex	chromatin binding|histone binding			endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	5		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0633)|OV - Ovarian serous cystadenocarcinoma(136;0.188)		TCGAGGACAAGAATTTATTAG	0.358													33	50					3.99451e-17	5.34789e-17	1	1	0	T	119226904	G	T	119226904	4	4	48	1	0	0	0	0	0	1	0	0	1036	943	33	2	210	2	ASF1A	6	119226904	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	670206	119226904	51888163	1770	6164										
FAM184A	79632	broad.mit.edu	37	chr6	119301348	119301348	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccatagtttgaaatgcaagGacatgtgcttcttttaatga	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:119301348G>A	ENST00000338891.7	-	10	2699	c.2256C>T	c.(2254-2256)gtC>gtT	p.V752V	FAM184A_ENST00000521531.1_Silent_p.V752V|FAM184A_ENST00000368475.4_Silent_p.V632V|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Silent_p.V632V	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	752										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						GAAATGCAAGGACATGTGCTT	0.388													15	40					0	0	1	0	0	A	119301348	G	A	119301348	2	1	48	1	0	0	0	0	0	0	0	1	5541	1161	41	3		3	FAM184A	6	119301348	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	74444	119301348	51813719	1771	6165										
GJA1	2697	broad.mit.edu	37	chr6	121768608	121768608	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctctctcgccccacggaGaaaaccatcttcatcatctt	4	16	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:121768608G>T	ENST00000282561.3	+	2	772	c.615G>T	c.(613-615)gaG>gaT	p.E205D		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	205					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	GCCCCACGGAGAAAACCATCT	0.473													32	65					2.81731e-10	3.44686e-10	1	1	0	T	121768608	G	T	121768608	3	4	48	1	0	0	0	0	1	0	0	0	6441	933	33	2	617	2	GJA1	6	121768608	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2467260	121768608	49346459	1772	6166										
SERINC1	57515	broad.mit.edu	37	chr6	122774932	122774932	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctgcataccaacatctcGagttcccttcttccattttt	3	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:122774932G>A	ENST00000368454.1	-	7	901	c.572C>T	c.(571-573)tCg>tTg	p.S191L	SERINC1_ENST00000339697.3_Missense_Mutation_p.S191L			Q9NRX5	SERC1_HUMAN	serine incorporator 1	191					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(1)	13				GBM - Glioblastoma multiforme(226;0.126)		CCAACATCTCGAGTTCCCTTC	0.388													9	54					0	0	1	0	0	A	122774932	G	A	122774932	3	1	48	1	0	0	0	0	1	0	0	0	14132	1059	37	1	813	1	SERINC1	6	122774932	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1006324	122774932	48340135	1773	6167										
NCOA7	135112	broad.mit.edu	37	chr6	126242114	126242114	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactgttgaagaggcaaagcGcaggaagagcacatgcagct	13	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:126242114G>A	ENST00000368357.3	+	13	2622	c.2270G>A	c.(2269-2271)cGc>cAc	p.R757H	NCOA7_ENST00000229634.9_Missense_Mutation_p.R642H|NCOA7_ENST00000392477.2_Missense_Mutation_p.R757H	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	757					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAGGCAAAGCGCAGGAAGAGC	0.453													28	48					0	0	1	0	0	A	126242114	G	A	126242114	3	1	48	1	0	0	0	0	1	0	0	0	10280	1087	38	1	2312	1	NCOA7	6	126242114	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3467182	126242114	44872953	1774	6168										
TRMT11	60487	broad.mit.edu	37	chr6	126314910	126314910	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attttcaatacaggaaataaAgtctttgcttttgctttttg	6	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:126314910A>G	ENST00000334379.5	+	2	201	c.80A>G	c.(79-81)aAg>aGg	p.K27R	TRMT11_ENST00000450358.1_Missense_Mutation_p.K27R|TRMT11_ENST00000368332.3_Missense_Mutation_p.K27R|TRMT11_ENST00000489934.1_Intron	NM_001031712.2	NP_001026882.2	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11 homolog (S. cerevisiae)	27					tRNA processing		methyltransferase activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(226;0.0356)		CAGGAAATAAAGTCTTTGCTT	0.299													14	17					0	0	1	0	0	G	126314910	A	G	126314910	3	3	48	1	0	0	0	0	1	0	0	0	16622	72	3	4	86	4	TRMT11	6	126314910	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	72796	126314910	44800157	1775	6169										
RNF146	81847	broad.mit.edu	37	chr6	127608732	127608732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaccagacagtacccgatcGatcagatcgatcgggaactg	10	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:127608732G>A	ENST00000368314.1	+	3	1398	c.974G>A	c.(973-975)cGa>cAa	p.R325Q	RNF146_ENST00000356799.2_Missense_Mutation_p.R324Q|RNF146_ENST00000309649.3_Missense_Mutation_p.R324Q	NM_001242849.1|NM_001242850.1|NM_001242851.1	NP_001229778.1|NP_001229779.1|NP_001229780.1	Q9NTX7	RN146_HUMAN	ring finger protein 146	325					positive regulation of canonical Wnt receptor signaling pathway|protein autoubiquitination|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol	poly-ADP-D-ribose binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(226;0.0407)|all cancers(137;0.2)		GTACCCGATCGATCAGATCGA	0.488													19	47					0	0	1	0	0	A	127608732	G	A	127608732	3	1	48	1	0	0	0	0	1	0	0	0	13499	1058	37	1	973	1	RNF146	6	127608732	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1293822	127608732	43506335	1776	6170										
THEMIS	387357	broad.mit.edu	37	chr6	128134152	128134152	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaggctgagctttcatatCtccgcatcatgtaatattgc	9	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:128134152C>A	ENST00000368250.1	-	5	1895	c.1397G>T	c.(1396-1398)aGa>aTa	p.R466I	THEMIS_ENST00000368248.2_Missense_Mutation_p.R545I|THEMIS_ENST00000537166.1_Missense_Mutation_p.R510I|THEMIS_ENST00000543064.1_Missense_Mutation_p.R545I			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	545	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						GCTTTCATATCTCCGCATCAT	0.458													38	57					1.42033e-22	1.97588e-22	1	1	0	A	128134152	C	A	128134152	3	1	48	1	0	0	0	0	1	0	0	0	15919	913	32	2	424	2	THEMIS	6	128134152	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	525420	128134152	42980915	1777	6171										
LAMA2	3908	broad.mit.edu	37	chr6	129637245	129637245	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtgacccgagaagacttCttggatatactatatgatat	8	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:129637245C>A	ENST00000421865.2	+	27	4036	c.3987C>A	c.(3985-3987)ttC>ttA	p.F1329L		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1329	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGAAGACTTCTTGGATATAC	0.338													19	41					2.94398e-08	3.45884e-08	1	1	0	A	129637245	C	A	129637245	3	1	48	1	0	0	0	0	1	0	0	0	8644	912	32	2	4093	2	LAMA2	6	129637245	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1503093	129637245	41477822	1778	6172										
L3MBTL3	84456	broad.mit.edu	37	chr6	130413911	130413911	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcactttgatggctggaacAattgctatgattactggata	9	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:130413911A>G	ENST00000529410.1	+	19	2019	c.1540A>G	c.(1540-1542)Aat>Gat	p.N514D	L3MBTL3_ENST00000533560.1_Missense_Mutation_p.N489D|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.N489D|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.N514D|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.N514D|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.N489D			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	514					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TGGCTGGAACAATTGCTATGA	0.423													13	32					0	0	1	0	0	G	130413911	A	G	130413911	3	3	48	1	0	0	0	0	1	0	0	0	8631	130	5	4	1598	4	L3MBTL3	6	130413911	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	776666	130413911	40701156	1779	6173										
EPB41L2	2037	broad.mit.edu	37	chr6	131201347	131201347	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctactctcaaggaatttttCtgtgaaattaaatcacacac	4	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:131201347C>A	ENST00000337057.3	-	13	2015		c.e13-1		EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000527659.1_Intron|EPB41L2_ENST00000530481.1_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000524581.1_Intron|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000368128.2_Splice_Site|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000529208.1_Intron|EPB41L2_ENST00000530757.1_Splice_Site|EPB41L2_ENST00000531410.1_Splice_Site|EPB41L2_ENST00000527411.1_Intron|EPB41L2_ENST00000525271.1_Intron	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		AGGAATTTTTCTGTGAAATTA	0.358													8	10					0.27861	0.279356	1	1	0	A	131201347	C	A	131201347	5	1	48	1	0	0	0	0	0	0	1	0	5181	927	32	2	1212	2	EPB41L2	6	131201347	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	787436	131201347	39913720	1780	6174										
ARG1	383	broad.mit.edu	37	chr6	131904520	131904520	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaggccaattcatctaagtTttgatgttgacggactggac	10	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:131904520T>G	ENST00000368087.3	+	7	830	c.691T>G	c.(691-693)Ttt>Gtt	p.F231V	MED23_ENST00000354577.4_Intron|ARG1_ENST00000476845.1_Intron|ARG1_ENST00000356962.2_Missense_Mutation_p.F239V			P05089	ARGI1_HUMAN	arginase 1	231					arginine catabolic process|urea cycle	cytosol	arginase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|skin(3)	14	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0106)|OV - Ovarian serous cystadenocarcinoma(155;0.0713)	L-Ornithine(DB00129)	TCATCTAAGTTTTGATGTTGA	0.403													32	67					0	0	1	0	0	G	131904520	T	G	131904520	3	3	48	1	0	0	0	0	1	0	0	0	854	1841	64	4	717	4	ARG1	6	131904520	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	703173	131904520	39210547	1781	6175										
ENPP3	5169	broad.mit.edu	37	chr6	132006568	132006568	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattttcccagaataaacttCttctacatgtacgaagggcc	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:132006568C>A	ENST00000414305.1	+	14	1513	c.1185C>A	c.(1183-1185)ttC>ttA	p.F395L	ENPP3_ENST00000357639.3_Missense_Mutation_p.F395L|ENPP3_ENST00000358229.5_Missense_Mutation_p.F395L			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	395	Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GAATAAACTTCTTCTACATGT	0.363													45	95					8.86878e-18	1.19361e-17	1	1	0	A	132006568	C	A	132006568	3	1	48	1	0	0	0	0	1	0	0	0	5159	912	32	2	1235	2	ENPP3	6	132006568	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	102048	132006568	39108499	1782	6176										
TAAR9	134860	broad.mit.edu	37	chr6	132860038	132860038	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgggtcctactttgttttCttctattctttatacccaat	4	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:132860038C>A	ENST00000434551.1	+	0	610					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		ACTTTGTTTTCTTCTATTCTT	0.438													38	49					2.1956e-27	3.11292e-27	1	1	0	A	132860038	C	A	132860038	1	1	48	0	1	0	0	0	0	0	0	0	15550	913	32	2		2	TAAR9	6	132860038	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	853470	132860038	38255029	1783	6177										
SGK1	6446	broad.mit.edu	37	chr6	134638579	134638579	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttcttgactgggaatccaTtcatgtctttgtttaccatt	6	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:134638579T>C	ENST00000367858.5	-	1	617	c.20A>G	c.(19-21)aAt>aGt	p.N7S	SGK1_ENST00000524929.1_Missense_Mutation_p.N7S	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	0	Necessary for localization to the cytoplasm.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TGGGAATCCATTCATGTCTTT	0.423													45	108					0	0	1	0	0	C	134638579	T	C	134638579	3	2	48	1	0	0	0	0	1	0	0	0	14260	1493	52	4	1982	4	SGK1	6	134638579	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1778541	134638579	36476488	1784	6178										
ALDH8A1	64577	broad.mit.edu	37	chr6	135271107	135271107	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacttcccctgttgatgggtCgtaagaatctatatatgagc	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:135271107C>T	ENST00000265605.2	-	1	153	c.85G>A	c.(85-87)Gac>Aac	p.D29N	ALDH8A1_ENST00000367845.2_Missense_Mutation_p.D29N|ALDH8A1_ENST00000367847.2_Missense_Mutation_p.D29N	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	29					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		GTTGATGGGTCGTAAGAATCT	0.373													18	40					0	0	1	0	0	T	135271107	C	T	135271107	3	4	48	1	0	0	0	0	1	0	0	0	502	884	31	1	1406	1	ALDH8A1	6	135271107	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	632528	135271107	35843960	1785	6179										
BCLAF1	9774	broad.mit.edu	37	chr6	136590607	136590607	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taagatttgtattccttgtaAtcttttggagttttttcctg	7	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136590607A>C	ENST00000531224.1	-	9	2439	c.2187T>G	c.(2185-2187)gaT>gaG	p.D729E	BCLAF1_ENST00000353331.4_Missense_Mutation_p.D727E|BCLAF1_ENST00000530767.1_Missense_Mutation_p.D556E|BCLAF1_ENST00000392348.2_Missense_Mutation_p.D727E|BCLAF1_ENST00000527536.1_Missense_Mutation_p.D729E|BCLAF1_ENST00000527759.1_Missense_Mutation_p.D727E|BCLAF1_ENST00000529917.1_5'UTR	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	729					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATTCCTTGTAATCTTTTGGAG	0.363													4	69					0	0	1	0	0	C	136590607	A	C	136590607	3	2	48	1	0	0	0	0	1	0	0	0	1381	98	4	4	595	4	BCLAF1	6	136590607	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1319500	136590607	34524460	1786	6180										
BCLAF1	9774	broad.mit.edu	37	chr6	136597112	136597112	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctcgtgcatccagattCttgtgtagagggggactgta	12	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136597112C>A	ENST00000531224.1	-	5	1803	c.1551G>T	c.(1549-1551)aaG>aaT	p.K517N	BCLAF1_ENST00000353331.4_Missense_Mutation_p.K515N|BCLAF1_ENST00000530767.1_Missense_Mutation_p.K344N|BCLAF1_ENST00000392348.2_Missense_Mutation_p.K515N|BCLAF1_ENST00000527536.1_Missense_Mutation_p.K517N|BCLAF1_ENST00000527759.1_Missense_Mutation_p.K515N	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	517					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CATCCAGATTCTTGTGTAGAG	0.413													12	153					1.3612e-06	1.53357e-06	1	1	0	A	136597112	C	A	136597112	3	1	48	1	0	0	0	0	1	0	0	0	1381	912	32	2	1247	2	BCLAF1	6	136597112	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6505	136597112	34517955	1787	6181										
BCLAF1	9774	broad.mit.edu	37	chr6	136597215	136597215	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttattctttcagaatttTtgtcttcttctttgtgctta	5	7	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136597215T>G	ENST00000531224.1	-	5	1700	c.1448A>C	c.(1447-1449)aAa>aCa	p.K483T	BCLAF1_ENST00000353331.4_Missense_Mutation_p.K481T|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000392348.2_Missense_Mutation_p.K481T|BCLAF1_ENST00000527536.1_Missense_Mutation_p.K483T|BCLAF1_ENST00000527759.1_Missense_Mutation_p.K481T	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	483					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTCAGAATTTTTGTCTTCTTC	0.358													4	80					0	0	1	0	0	G	136597215	T	G	136597215	3	3	48	1	0	0	0	0	1	0	0	0	1381	1841	64	4	1350	4	BCLAF1	6	136597215	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	103	136597215	34517852	1788	6182										
BCLAF1	9774	broad.mit.edu	37	chr6	136597398	136597398	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgagatgcagtagcaaaaCttttaccctgatctgcgagg	12	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136597398C>T	ENST00000531224.1	-	5	1517	c.1265G>A	c.(1264-1266)aGt>aAt	p.S422N	BCLAF1_ENST00000353331.4_Missense_Mutation_p.S420N|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000392348.2_Missense_Mutation_p.S420N|BCLAF1_ENST00000527536.1_Missense_Mutation_p.S422N|BCLAF1_ENST00000527759.1_Missense_Mutation_p.S420N	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	422					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGTAGCAAAACTTTTACCCTG	0.418													40	207					0	0	1	0	0	T	136597398	C	T	136597398	3	4	48	1	0	0	0	0	1	0	0	0	1381	565	20	3	1533	3	BCLAF1	6	136597398	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	183	136597398	34517669	1789	6183										
BCLAF1	9774	broad.mit.edu	37	chr6	136599082	136599082	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaacggcccctagactcatCtcttggagcattctgtggtg	12	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136599082C>A	ENST00000531224.1	-	4	1189	c.937G>T	c.(937-939)Gat>Tat	p.D313Y	BCLAF1_ENST00000353331.4_Missense_Mutation_p.D311Y|BCLAF1_ENST00000530767.1_Missense_Mutation_p.D313Y|BCLAF1_ENST00000392348.2_Missense_Mutation_p.D311Y|BCLAF1_ENST00000527536.1_Missense_Mutation_p.D313Y|BCLAF1_ENST00000527759.1_Missense_Mutation_p.D311Y	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	313					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTAGACTCATCTCTTGGAGCA	0.428													10	66					2.17888e-05	2.39107e-05	1	1	0	A	136599082	C	A	136599082	3	1	48	1	0	0	0	0	1	0	0	0	1381	913	32	2	1865	2	BCLAF1	6	136599082	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1684	136599082	34515985	1790	6184										
MAP7	9053	broad.mit.edu	37	chr6	136667149	136667149	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccaatgggtaagtttataAtttcttcaaaattttcattc	4	6	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136667149A>C	ENST00000354570.3	-	17	2494	c.2084T>G	c.(2083-2085)aTt>aGt	p.I695S	MAP7_ENST00000438100.2_Missense_Mutation_p.I680S|MAP7_ENST00000454590.1_Missense_Mutation_p.I717S|MAP7_ENST00000432797.2_Missense_Mutation_p.I549S|MAP7_ENST00000544465.1_Missense_Mutation_p.I680S	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	695					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		TAAGTTTATAATTTCTTCAAA	0.323													13	20					0	0	1	0	0	C	136667149	A	C	136667149	3	2	48	1	0	0	0	0	1	0	0	0	9315	101	4	4	173	4	MAP7	6	136667149	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	68067	136667149	34447918	1791	6185										
MAP7	9053	broad.mit.edu	37	chr6	136742892	136742892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaaattgcagaggcagggCggctggaggcatttttctta	14	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:136742892C>T	ENST00000354570.3	-	2	523	c.113G>A	c.(112-114)cGc>cAc	p.R38H	MAP7_ENST00000438100.2_Missense_Mutation_p.R60H|MAP7_ENST00000454590.1_Missense_Mutation_p.R60H|MAP7_ENST00000432797.2_5'UTR|MAP7_ENST00000544465.1_Missense_Mutation_p.R23H	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	38					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AGAGGCAGGGCGGCTGGAGGC	0.373													21	40					0	0	1	0	0	T	136742892	C	T	136742892	3	4	48	1	0	0	0	0	1	0	0	0	9315	768	27	1	2204	1	MAP7	6	136742892	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	75743	136742892	34372175	1792	6186										
KIAA1244	57221	broad.mit.edu	37	chr6	138559762	138559762	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagttacgacagaggcaggaGaatacggtgagtctgtgaca	14	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:138559762G>T	ENST00000251691.4	+	6	703	c.537G>T	c.(535-537)gaG>gaT	p.E179D		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	179					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGAGGCAGGAGAATACGGTGA	0.557													46	80					1.48734e-19	2.02648e-19	1	1	0	T	138559762	G	T	138559762	3	4	48	1	0	0	0	0	1	0	0	0	8258	933	33	2	559	2	KIAA1244	6	138559762	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1816870	138559762	32555305	1793	6187										
ECT2L	345930	broad.mit.edu	37	chr6	139159530	139159530	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaaggatgcaagtggccaAagtggacttctctacagtgt	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:139159530A>G	ENST00000423192.1	+	4	382	c.221A>G	c.(220-222)aAa>aGa	p.K74R	ECT2L_ENST00000541398.1_Missense_Mutation_p.K5R|ECT2L_ENST00000367682.2_Missense_Mutation_p.K74R			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	74					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						CAAGTGGCCAAAGTGGACTTC	0.388			"N, Splice, Mis"		ETP ALL								18	23					0	0	1	0	0	G	139159530	A	G	139159530	3	3	48	1	0	0	0	0	1	0	0	0	4928	14	1	4	231	4	ECT2L	6	139159530	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	599768	139159530	31955537	1794	6188										
TXLNB	167838	broad.mit.edu	37	chr6	139563669	139563669	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggcacggtgaggcttagtcGacgccttccagattggtgtc	14	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:139563669G>A	ENST00000358430.3	-	10	2281	c.2049C>T	c.(2047-2049)gtC>gtT	p.V683V	RP1-225E12.3_ENST00000585874.1_RNA	NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	683						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		AGGCTTAGTCGACGCCTTCCA	0.582													10	59					0	0	1	0	0	A	139563669	G	A	139563669	2	1	48	1	0	0	0	0	0	0	0	1	16849	1045	37	1		1	TXLNB	6	139563669	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	404139	139563669	31551398	1795	6189										
TXLNB	167838	broad.mit.edu	37	chr6	139581502	139581502	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccgcttccttcatcatttCttgggcctgctcaagctttg	7	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:139581502C>A	ENST00000358430.3	-	6	1187	c.955G>T	c.(955-957)Gaa>Taa	p.E319*		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	319						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TTCATCATTTCTTGGGCCTGC	0.408													12	25					7.03913e-09	8.36985e-09	1	1	0	A	139581502	C	A	139581502	4	1	48	1	0	0	0	0	0	1	0	0	16849	922	32	2	1119	2	TXLNB	6	139581502	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17833	139581502	31533565	1796	6190										
HIVEP2	3097	broad.mit.edu	37	chr6	143081489	143081489	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtcataagctgagtaactCgaatacttggcaaagtaacc	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:143081489C>T	ENST00000367603.2	-	9	6678	c.5936G>A	c.(5935-5937)cGa>cAa	p.R1979Q	HIVEP2_ENST00000012134.2_Missense_Mutation_p.R1979Q|HIVEP2_ENST00000367604.1_Missense_Mutation_p.R1979Q	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1979					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R1979L(1)		NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CTGAGTAACTCGAATACTTGG	0.473													42	90					0	0	1	0	0	T	143081489	C	T	143081489	3	4	48	1	0	0	0	0	1	0	0	0	7227	884	31	1	1412	1	HIVEP2	6	143081489	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3499987	143081489	28033578	1797	6191										
GRM1	2911	broad.mit.edu	37	chr6	146708098	146708098	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaatgaatatgtgcaagatGagttcacctgcaaagcttgt	10	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:146708098G>T	ENST00000392299.2	+	7	2145	c.1675G>T	c.(1675-1677)Gag>Tag	p.E559*	GRM1_ENST00000282753.1_Nonsense_Mutation_p.E559*|GRM1_ENST00000507907.1_Nonsense_Mutation_p.E559*|GRM1_ENST00000355289.4_Nonsense_Mutation_p.E559*|GRM1_ENST00000361719.2_Nonsense_Mutation_p.E559*|GRM1_ENST00000492807.2_Nonsense_Mutation_p.E559*			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	559					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGTGCAAGATGAGTTCACCTG	0.438													49	90					1.67211e-32	2.39548e-32	1	1	0	T	146708098	G	T	146708098	4	4	48	1	0	0	0	0	0	1	0	0	6836	1291	45	2	1697	2	GRM1	6	146708098	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3626609	146708098	24406969	1798	6192										
GRM1	2911	broad.mit.edu	37	chr6	146755216	146755216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaccaagaccctttacaacGtagaggaggaggaggatgcc	13	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:146755216G>A	ENST00000361719.2	+	9	3339	c.2869G>A	c.(2869-2871)Gta>Ata	p.V957I	GRM1_ENST00000282753.1_Missense_Mutation_p.V957I|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000392299.2_3'UTR|GRM1_ENST00000492807.2_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	957					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCTTTACAACGTAGAGGAGGA	0.587													15	138					0	0	1	0	0	A	146755216	G	A	146755216	3	1	48	1	0	0	0	0	1	0	0	0	6836	1145	40	1	2964	1	GRM1	6	146755216	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	47118	146755216	24359851	1799	6193										
STXBP5	0	broad.mit.edu	37	chr6	147635409	147635409	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttttataggaatggcccAtcaacggaggtaattggggc	12	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:147635409A>G	ENST00000367481.3	+	13	1411	c.1303A>G	c.(1303-1305)Atc>Gtc	p.I435V	STXBP5_ENST00000367480.3_Missense_Mutation_p.I435V|STXBP5_ENST00000321680.6_Missense_Mutation_p.I435V|STXBP5_ENST00000179882.6_Missense_Mutation_p.I106V	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	435					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GGAATGGCCCATCAACGGAGG	0.388													33	71					0	0	1	0	0	G	147635409	A	G	147635409	3	3	48	1	0	0	0	0	1	0	0	0	15411	217	8	4	1353	4	STXBP5	6	147635409	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	880193	147635409	23479658	1800	6194										
LATS1	9113	broad.mit.edu	37	chr6	149982885	149982885	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaaacatatactagatcgcGatttttaatctctgagcctg	6	8	1	2	rs139248642		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:149982885G>A	ENST00000543571.1	-	8	3920	c.3373C>T	c.(3373-3375)Cgc>Tgc	p.R1125C	LATS1_ENST00000253339.5_Missense_Mutation_p.R1125C	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	1125					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ACTAGATCGCGATTTTTAATC	0.353													30	50					0	0	1	0	0	A	149982885	G	A	149982885	3	1	48	1	0	0	0	0	1	0	0	0	8684	1058	37	1	23	1	LATS1	6	149982885	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2347476	149982885	21132182	1801	6195										
LATS1	9113	broad.mit.edu	37	chr6	150001229	150001229	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcccattctaattaataggCtcatcatatcacccccagga	5	13	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:150001229C>A	ENST00000543571.1	-	5	2922	c.2375G>T	c.(2374-2376)aGc>aTc	p.S792I	LATS1_ENST00000253339.5_Missense_Mutation_p.S792I|LATS1_ENST00000542747.1_5'UTR	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	792	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AATTAATAGGCTCATCATATC	0.368													12	77					0.010729	0.0110271	1	1	0	A	150001229	C	A	150001229	3	1	48	1	0	0	0	0	1	0	0	0	8684	797	28	5	1033	5	LATS1	6	150001229	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18344	150001229	21113838	1802	6196										
LATS1	9113	broad.mit.edu	37	chr6	150001373	150001373	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taacatgagcgacttgatttCgaagaagaacatctttcttt	7	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:150001373C>T	ENST00000543571.1	-	5	2778	c.2231G>A	c.(2230-2232)cGa>cAa	p.R744Q	LATS1_ENST00000253339.5_Missense_Mutation_p.R744Q|LATS1_ENST00000542747.1_5'UTR	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	744	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity	p.R744Q(2)|p.R744L(2)		central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		GACTTGATTTCGAAGAAGAAC	0.383													42	67					0	0	1	0	0	T	150001373	C	T	150001373	3	4	48	1	0	0	0	0	1	0	0	0	8684	884	31	1	1177	1	LATS1	6	150001373	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	144	150001373	21113694	1803	6197										
ULBP3	79465	broad.mit.edu	37	chr6	150386730	150386730	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaggaacttccgtccatcGaagctgaactgccaagatcc	10	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:150386730G>A	ENST00000367339.1	-	3	460	c.432C>T	c.(430-432)ttC>ttT	p.F144F	ULBP3_ENST00000438272.2_Silent_p.F144F			Q9BZM4	N2DL3_HUMAN	UL16 binding protein 3	144	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation	anchored to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	9		Ovarian(120;0.12)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.45e-12)		TCCGTCCATCGAAGCTGAACT	0.527													4	129					0	0	1	0	0	A	150386730	G	A	150386730	2	1	48	1	0	0	0	0	0	0	0	1	17033	1049	37	1		1	ULBP3	6	150386730	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	385357	150386730	20728337	1804	6198										
PLEKHG1	57480	broad.mit.edu	37	chr6	151153217	151153217	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcagaagattaagaaggcGaatcaacttttaaaagtgaa	9	4	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:151153217G>A	ENST00000367328.1	+	16	3282	c.2970G>A	c.(2968-2970)gcG>gcA	p.A990A	PLEKHG1_ENST00000358517.2_Silent_p.A990A	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	990					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TTAAGAAGGCGAATCAACTTT	0.498													107	135					0	0	1	0	0	A	151153217	G	A	151153217	2	1	48	1	0	0	0	0	0	0	0	1	12115	1045	37	1		1	PLEKHG1	6	151153217	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	766487	151153217	19961850	1805	6199										
AKAP12	9590	broad.mit.edu	37	chr6	151671102	151671102	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttaccagcactggcttaAaaaagctttctggaaagaaa	7	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:151671102A>C	ENST00000402676.2	+	4	1816	c.1576A>C	c.(1576-1578)Aaa>Caa	p.K526Q	AKAP12_ENST00000253332.1_Missense_Mutation_p.K526Q|AKAP12_ENST00000354675.6_Missense_Mutation_p.K428Q|AKAP12_ENST00000359755.5_Missense_Mutation_p.K421Q	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	526	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CACTGGCTTAAAAAAGCTTTC	0.507													49	70					0	0	1	0	0	C	151671102	A	C	151671102	3	2	48	1	0	0	0	0	1	0	0	0	445	15	1	4	1615	4	AKAP12	6	151671102	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	517885	151671102	19443965	1806	6200										
AKAP12	9590	broad.mit.edu	37	chr6	151671492	151671492	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcctctgaaatgcaagaaGaaatgaaagggagcgtggaa	13	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:151671492G>T	ENST00000402676.2	+	4	2206	c.1966G>T	c.(1966-1968)Gaa>Taa	p.E656*	AKAP12_ENST00000253332.1_Nonsense_Mutation_p.E656*|AKAP12_ENST00000354675.6_Nonsense_Mutation_p.E558*|AKAP12_ENST00000359755.5_Nonsense_Mutation_p.E551*	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	656					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AATGCAAGAAGAAATGAAAGG	0.483													20	48					2.4624e-09	2.95225e-09	1	1	0	T	151671492	G	T	151671492	4	4	48	1	0	0	0	0	0	1	0	0	445	943	33	2	2005	2	AKAP12	6	151671492	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	390	151671492	19443575	1807	6201										
C6orf211	79624	broad.mit.edu	37	chr6	151789606	151789606	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaatgatatggaacatctTtggtcattgcttagcaattg	9	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:151789606T>G	ENST00000367294.3	+	5	946	c.687T>G	c.(685-687)ctT>ctG	p.L229L	C6orf211_ENST00000545879.1_Silent_p.L110L	NM_024573.1	NP_078849.1	Q9H993	CF211_HUMAN	chromosome 6 open reading frame 211	229							protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(7)	15			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		TGGAACATCTTTGGTCATTGC	0.343													20	36					0	0	1	0	0	G	151789606	T	G	151789606	2	3	48	1	0	0	0	0	0	0	0	1	2368	1828	64	4		4	C6orf211	6	151789606	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	118114	151789606	19325461	1808	6202										
SYNE1	23345	broad.mit.edu	37	chr6	152476036	152476036	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatagattacctcaaatttCtttagttcttccttggcaac	4	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:152476036C>A	ENST00000367255.5	-	133	24721	c.24120G>T	c.(24118-24120)aaG>aaT	p.K8040N	SYNE1_ENST00000423061.1_Missense_Mutation_p.K7969N|SYNE1_ENST00000539504.1_Missense_Mutation_p.K195N|SYNE1_ENST00000265368.4_Missense_Mutation_p.K8040N|SYNE1_ENST00000341594.5_Missense_Mutation_p.K7652N|SYNE1_ENST00000356820.4_Missense_Mutation_p.K2564N|SYNE1_ENST00000354674.4_Missense_Mutation_p.K195N|SYNE1_ENST00000448038.1_Missense_Mutation_p.K7969N|SYNE1_ENST00000347037.5_5'UTR	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8040					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTCAAATTTCTTTAGTTCTT	0.383										HNSCC(10;0.0054)			47	70					1.48734e-19	2.02648e-19	1	1	0	A	152476036	C	A	152476036	3	1	48	1	0	0	0	0	1	0	0	0	15501	912	32	2	2402	2	SYNE1	6	152476036	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	686430	152476036	18639031	1809	6203										
SYNE1	23345	broad.mit.edu	37	chr6	152673366	152673366	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttcaactgctccatgtgAtcatgaatctcctttcttaa	4	12	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:152673366A>G	ENST00000367255.5	-	70	11977	c.11376T>C	c.(11374-11376)gaT>gaC	p.D3792D	SYNE1_ENST00000423061.1_Silent_p.D3777D|SYNE1_ENST00000265368.4_Silent_p.D3792D|SYNE1_ENST00000341594.5_Silent_p.D3763D|SYNE1_ENST00000448038.1_Silent_p.D3777D	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3792					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTCCATGTGATCATGAATCT	0.458										HNSCC(10;0.0054)			31	62					0	0	1	0	0	G	152673366	A	G	152673366	2	3	48	1	0	0	0	0	0	0	0	1	15501	330	12	4		4	SYNE1	6	152673366	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	197330	152673366	18441701	1810	6204										
SYNE1	23345	broad.mit.edu	37	chr6	152674558	152674558	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaatctcctcctccaggaatTttatttgttcctatgaaaga	6	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:152674558T>G	ENST00000367255.5	-	69	11694	c.11093A>C	c.(11092-11094)aAa>aCa	p.K3698T	SYNE1_ENST00000423061.1_Missense_Mutation_p.K3683T|SYNE1_ENST00000265368.4_Missense_Mutation_p.K3698T|SYNE1_ENST00000341594.5_Missense_Mutation_p.K3669T|SYNE1_ENST00000448038.1_Missense_Mutation_p.K3683T	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3698					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCAGGAATTTTATTTGTTC	0.388										HNSCC(10;0.0054)			12	36					0	0	1	0	0	G	152674558	T	G	152674558	3	3	48	1	0	0	0	0	1	0	0	0	15501	1841	64	4	15685	4	SYNE1	6	152674558	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1192	152674558	18440509	1811	6205										
SYNE1	23345	broad.mit.edu	37	chr6	152774635	152774635	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgactttccaggaatttctAaatttctcttacatttggac	6	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:152774635A>G	ENST00000495090.2	-	12	1822	c.1814T>C	c.(1813-1815)tTa>tCa	p.L605S	SYNE1_ENST00000423061.1_Intron|SYNE1_ENST00000265368.4_Intron|SYNE1_ENST00000341594.5_Intron|SYNE1_ENST00000367253.4_Intron|SYNE1_ENST00000367255.5_Intron|SYNE1_ENST00000413186.2_Intron|SYNE1_ENST00000367248.3_Intron|SYNE1_ENST00000448038.1_Intron			Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7274					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGAATTTCTAAATTTCTCTT	0.368										HNSCC(10;0.0054)			29	45					0	0	1	0	0	G	152774635	A	G	152774635	3	3	48	1	0	0	0	0	1	0	0	0	15501	377	13	4		4	SYNE1	6	152774635	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	100077	152774635	18340432	1812	6206										
MYCT1	80177	broad.mit.edu	37	chr6	153019160	153019160	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttctgtttttcttctcttTcttctatttcttgtggatat	4	8	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:153019160T>G	ENST00000367245.5	+	1	131	c.123T>G	c.(121-123)ttT>ttG	p.F41L	MYCT1_ENST00000529453.1_Missense_Mutation_p.F41L	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	41						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TTCTTCTCTTTCTTCTATTTC	0.318													5	12					0	0	1	0	0	G	153019160	T	G	153019160	3	3	48	1	0	0	0	0	1	0	0	0	10069	1780	62	4	125	4	MYCT1	6	153019160	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	244525	153019160	18095907	1813	6207										
VIP	7432	broad.mit.edu	37	chr6	153076473	153076473	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgggtcaactttctgccaaAaagtaccttgagtctcttat	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:153076473A>C	ENST00000367244.3	+	4	472	c.300A>C	c.(298-300)aaA>aaC	p.K100N	VIP_ENST00000367243.3_Missense_Mutation_p.K100N	NM_003381.3	NP_003372.1	P01282	VIP_HUMAN	vasoactive intestinal peptide	100					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)|skin(1)	6		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		TTTCTGCCAAAAAGTACCTTG	0.308													10	21					0	0	1	0	0	C	153076473	A	C	153076473	3	2	48	1	0	0	0	0	1	0	0	0	17226	11	1	4	310	4	VIP	6	153076473	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	57313	153076473	18038594	1814	6208										
IPCEF1	26034	broad.mit.edu	37	chr6	154481002	154481002	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagggagaagaaggtgatttCttgagttcctggggggtgtc	18	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:154481002C>A	ENST00000265198.4	-	12	1430	c.1275G>T	c.(1273-1275)aaG>aaT	p.K425N	OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000519344.1_Missense_Mutation_p.K397N|IPCEF1_ENST00000367220.4_Missense_Mutation_p.K426N|IPCEF1_ENST00000422970.2_Missense_Mutation_p.K426N	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						AAGGTGATTTCTTGAGTTCCT	0.463													6	32					0.217242	0.218251	1	1	0	A	154481002	C	A	154481002	3	1	48	1	0	0	0	0	1	0	0	0	7834	912	32	2	42	2	IPCEF1	6	154481002	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1404529	154481002	16634065	1815	6209										
TIAM2	26230	broad.mit.edu	37	chr6	155458506	155458506	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatttatgagaatttcatgCgagagttggaaatgagcagg	12	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:155458506C>T	ENST00000461783.3	+	7	2663	c.1390C>T	c.(1390-1392)Cga>Tga	p.R464*	TIAM2_ENST00000360366.4_Nonsense_Mutation_p.R464*|TIAM2_ENST00000529824.2_Nonsense_Mutation_p.R464*|TIAM2_ENST00000456144.1_Nonsense_Mutation_p.R464*|TIAM2_ENST00000318981.5_Nonsense_Mutation_p.R464*|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	464					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAATTTCATGCGAGAGTTGGA	0.512													31	207					0	0	1	0	0	T	155458506	C	T	155458506	4	4	48	1	0	0	0	0	0	1	0	0	15950	760	27	1	1396	1	TIAM2	6	155458506	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	977504	155458506	15656561	1816	6210										
TIAM2	26230	broad.mit.edu	37	chr6	155569225	155569225	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtcctacctcatcaagccGgttcagagagtgctcaagta	10	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:155569225G>A	ENST00000461783.3	+	22	5017	c.3744G>A	c.(3742-3744)ccG>ccA	p.P1248P	TIAM2_ENST00000456877.2_Silent_p.P560P|TIAM2_ENST00000275246.7_Silent_p.P173P|TIAM2_ENST00000360366.4_Silent_p.P1272P|TIAM2_ENST00000528391.2_Silent_p.P584P|TIAM2_ENST00000529824.2_Silent_p.P1248P|TIAM2_ENST00000456144.1_Silent_p.P1248P|TIAM2_ENST00000318981.5_Silent_p.P1248P|TIAM2_ENST00000367174.2_Silent_p.P624P			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1248	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TCATCAAGCCGGTTCAGAGAG	0.592											OREG0017745	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	49					0	0	1	0	0	A	155569225	G	A	155569225	2	1	48	1	0	0	0	0	0	0	0	1	15950	1103	39	1		1	TIAM2	6	155569225	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	110719	155569225	15545842	1817	6211										
TIAM2	26230	broad.mit.edu	37	chr6	155578064	155578064	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgccccattaaacgaaaaGccaacagcaccaagagggac	8	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:155578064G>T	ENST00000461783.3	+	29	6188	c.4915G>T	c.(4915-4917)Gcc>Tcc	p.A1639S	TIAM2_ENST00000456877.2_Missense_Mutation_p.A951S|TIAM2_ENST00000275246.7_Missense_Mutation_p.A564S|TIAM2_ENST00000360366.4_Missense_Mutation_p.A1663S|TIAM2_ENST00000528391.2_Missense_Mutation_p.A983S|TIAM2_ENST00000529824.2_Missense_Mutation_p.A1668S|TIAM2_ENST00000456144.1_Missense_Mutation_p.A1668S|TIAM2_ENST00000318981.5_Missense_Mutation_p.A1639S|TIAM2_ENST00000367174.2_Missense_Mutation_p.A1015S			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1639				A -> T (in Ref. 7; BAC86170).	apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TAAACGAAAAGCCAACAGCAC	0.572													5	56					1.23904e-05	1.36503e-05	1	1	0	T	155578064	G	T	155578064	3	4	48	1	0	0	0	0	1	0	0	0	15950	971	34	5	5009	5	TIAM2	6	155578064	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8839	155578064	15537003	1818	6212										
CLDN20	49861	broad.mit.edu	37	chr6	155597436	155597436	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaatccagaagctagactcGacccacccacacagcagcct	8	16	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:155597436G>A	ENST00000367165.3	+	2	963	c.583G>A	c.(583-585)Gac>Aac	p.D195N	TFB1M_ENST00000367166.4_Intron	NM_001001346.3	NP_001001346.1	P56880	CLD20_HUMAN	claudin 20	195					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(2)	3				OV - Ovarian serous cystadenocarcinoma(155;7.82e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0114)		AGCTAGACTCGACCCACCCAC	0.408													18	39					0	0	1	0	0	A	155597436	G	A	155597436	3	1	48	1	0	0	0	0	1	0	0	0	3505	1058	37	1	585	1	CLDN20	6	155597436	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19372	155597436	15517631	1819	6213										
NOX3	50508	broad.mit.edu	37	chr6	155743877	155743877	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactgcatttgtaccatataGatttcagaagagcagcgaag	9	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:155743877G>T	ENST00000159060.2	-	10	1361	c.1259C>A	c.(1258-1260)tCt>tAt	p.S420Y		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	420							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GTACCATATAGATTTCAGAAG	0.498													42	69					6.48837e-15	8.49851e-15	1	1	0	T	155743877	G	T	155743877	3	4	48	1	0	0	0	0	1	0	0	0	10603	942	33	2	463	2	NOX3	6	155743877	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	146441	155743877	15371190	1820	6214										
ARID1B	57492	broad.mit.edu	37	chr6	157528886	157528886	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcggccaaggctttgctagCcatggccagagtggacgaaa	15	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:157528886C>T	ENST00000346085.5	+	20	6612	c.6611C>T	c.(6610-6612)gCc>gTc	p.A2204V	ARID1B_ENST00000275248.4_Missense_Mutation_p.A2186V|ARID1B_ENST00000367148.1_Missense_Mutation_p.A2244V|ARID1B_ENST00000350026.5_Missense_Mutation_p.A2191V	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2191					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GCTTTGCTAGCCATGGCCAGA	0.572													43	80					0	0	1	0	0	T	157528886	C	T	157528886	3	4	48	1	0	0	0	0	1	0	0	0	911	739	26	3	6689	3	ARID1B	6	157528886	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1785009	157528886	13586181	1821	6215										
FNDC1	84624	broad.mit.edu	37	chr6	159687252	159687252	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaattcactgaggtataaAatctacctcagtgacaacct	6	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:159687252A>C	ENST00000297267.9	+	21	5621	c.5421A>C	c.(5419-5421)aaA>aaC	p.K1807N	FNDC1_ENST00000340366.6_Missense_Mutation_p.K1744N	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1807						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TGAGGTATAAAATCTACCTCA	0.443													34	66					0	0	1	0	0	C	159687252	A	C	159687252	3	2	48	1	0	0	0	0	1	0	0	0	6000	11	1	4	5503	4	FNDC1	6	159687252	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2158366	159687252	11427815	1822	6216										
WTAP	9589	broad.mit.edu	37	chr6	160176595	160176595	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtgggttcccgccacgtTcagaatggcttggactcaag	12	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:160176595T>G	ENST00000358372.4	+	8	2900	c.1143T>G	c.(1141-1143)gtT>gtG	p.V381V	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	381					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		CCCGCCACGTTCAGAATGGCT	0.418													13	78					0	0	1	0	0	G	160176595	T	G	160176595	2	3	48	1	0	0	0	0	0	0	0	1	17468	1770	62	4		4	WTAP	6	160176595	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	489343	160176595	10938472	1823	6217										
TCP1	6950	broad.mit.edu	37	chr6	160201557	160201557	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacattgcagcttcaaaagTttcttcaccttccaaattgg	5	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:160201557T>C	ENST00000321394.7	-	9	1295	c.1015A>G	c.(1015-1017)Act>Gct	p.T339A	TCP1_ENST00000420894.2_Missense_Mutation_p.T339A|TCP1_ENST00000544255.1_Missense_Mutation_p.T115A|TCP1_ENST00000392168.2_Missense_Mutation_p.T184A	NM_030752.2	NP_110379.2	P17987	TCPA_HUMAN	t-complex 1	339					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(2)	10		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		GCTTCAAAAGTTTCTTCACCT	0.373													39	70					0	0	1	0	0	C	160201557	T	C	160201557	3	2	48	1	0	0	0	0	1	0	0	0	15768	1725	60	4	671	4	TCP1	6	160201557	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	24962	160201557	10913510	1824	6218										
PNLDC1	154197	broad.mit.edu	37	chr6	160240086	160240086	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaccataagtttcagaatCtctgcaagtttgatgtcagg	8	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:160240086C>T	ENST00000275275.5	+	17	1504	c.1333C>T	c.(1333-1335)Ctc>Ttc	p.L445F	PNLDC1_ENST00000392167.3_Missense_Mutation_p.L456F	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1	445						integral to membrane|nucleus	nucleic acid binding	p.L445I(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GTTTCAGAATCTCTGCAAGTT	0.517													31	52					0	0	1	0	0	T	160240086	C	T	160240086	3	4	48	1	0	0	0	0	1	0	0	0	12195	913	32	3	1395	3	PNLDC1	6	160240086	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	38529	160240086	10874981	1825	6219										
SLC22A3	6581	broad.mit.edu	37	chr6	160831867	160831867	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgggaaatacctctcatcaAattactcagaggtaatttct	6	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:160831867A>C	ENST00000392145.1	+	5	991	c.964A>C	c.(964-966)Aat>Cat	p.N322H	SLC22A3_ENST00000275300.2_Missense_Mutation_p.N322H			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	322						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		CCTCTCATCAAATTACTCAGA	0.383													10	15					0	0	1	0	0	C	160831867	A	C	160831867	3	2	48	1	0	0	0	0	1	0	0	0	14509	14	1	4	982	4	SLC22A3	6	160831867	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	591781	160831867	10283200	1826	6220										
LPA	4018	broad.mit.edu	37	chr6	161027561	161027561	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggtaatagttggaggcgcGacggcagtcccttctgcgtc	16	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:161027561G>A	ENST00000447678.1	-	18	2853	c.2733C>T	c.(2731-2733)gtC>gtT	p.V911V	LPA_ENST00000316300.5_Silent_p.V911V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3419	Kringle 8.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTGGAGGCGCGACGGCAGTCC	0.542													53	98					0	0	1	0	0	A	161027561	G	A	161027561	2	1	48	1	0	0	0	0	0	0	0	1	8947	1045	37	1		1	LPA	6	161027561	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	195694	161027561	10087506	1827	6221										
MAP3K4	4216	broad.mit.edu	37	chr6	161470911	161470911	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtagacaaagcactgaagcAgatggggttaagaaagttaa	12	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:161470911A>C	ENST00000392142.4	+	3	1755	c.1607A>C	c.(1606-1608)cAg>cCg	p.Q536P	MAP3K4_ENST00000366919.2_Missense_Mutation_p.Q536P|MAP3K4_ENST00000366920.2_Missense_Mutation_p.Q536P|MAP3K4_ENST00000348824.7_Missense_Mutation_p.Q536P	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	536					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GCACTGAAGCAGATGGGGTTA	0.438													11	56					0	0	1	0	0	C	161470911	A	C	161470911	3	2	48	1	0	0	0	0	1	0	0	0	9301	188	7	4	1617	4	MAP3K4	6	161470911	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	443350	161470911	9644156	1828	6222										
MAP3K4	4216	broad.mit.edu	37	chr6	161530819	161530819	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttcatggagtactgcgaTgaggggactttagaagaggt	14	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:161530819T>C	ENST00000392142.4	+	23	4417	c.4269T>C	c.(4267-4269)gaT>gaC	p.D1423D	MAP3K4_ENST00000366919.2_Silent_p.D1373D|MAP3K4_ENST00000366920.2_Silent_p.D1419D|MAP3K4_ENST00000348824.7_Silent_p.D1369D	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1423	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGTACTGCGATGAGGGGACTT	0.458													17	58					0	0	1	0	0	C	161530819	T	C	161530819	2	2	48	1	0	0	0	0	0	0	0	1	9301	1461	51	4		4	MAP3K4	6	161530819	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	59908	161530819	9584248	1829	6223										
RPS6KA2	6196	broad.mit.edu	37	chr6	166902356	166902356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggttccgtttgaagagagctCgcagcaaactctgtgcctcc	11	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:166902356C>T	ENST00000510118.1	-	12	1287	c.947G>A	c.(946-948)cGa>cAa	p.R316Q	RPS6KA2_ENST00000503859.1_Missense_Mutation_p.R299Q|RPS6KA2_ENST00000481261.2_Missense_Mutation_p.R202Q|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.R202Q|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.R291Q|RPS6KA2_ENST00000366863.2_Missense_Mutation_p.R137Q			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	291	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GAAGAGAGCTCGCAGCAAACT	0.562													7	17					0	0	1	0	0	T	166902356	C	T	166902356	3	4	48	1	0	0	0	0	1	0	0	0	13702	884	31	1	1377	1	RPS6KA2	6	166902356	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5371537	166902356	4212711	1830	6224										
TTLL2	83887	broad.mit.edu	37	chr6	167755167	167755167	+	Nonstop_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaataagcaacattcctaAgtggtaaaaaatcaaatcaa	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:167755167A>C	ENST00000239587.5	+	3	1867	c.1779A>C	c.(1777-1779)taA>taC	p.*593Y		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	0					protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AACATTCCTAAGTGGTAAAAA	0.373													4	25					0	0	1	0	0	C	167755167	A	C	167755167	4	2	48	1	0	0	0	0	0	0	0	0	16788	79	3	4	1789	4	TTLL2	6	167755167	Nonstop_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	852811	167755167	3359900	1831	6225										
FRMD1	79981	broad.mit.edu	37	chr6	168468077	168468077	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttcttccaatcttttgaGaagtacttgctgagcttttg	7	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:168468077G>T	ENST00000283309.6	-	3	418	c.354C>A	c.(352-354)ttC>ttA	p.F118L	FRMD1_ENST00000440994.2_Missense_Mutation_p.F50L|FRMD1_ENST00000537786.1_5'UTR	NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	118	FERM.					cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		AATCTTTTGAGAAGTACTTGC	0.478													16	47					1.5739e-10	1.93697e-10	1	1	0	T	168468077	G	T	168468077	3	4	48	1	0	0	0	0	1	0	0	0	6083	933	33	2	1331	2	FRMD1	6	168468077	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	712910	168468077	2646990	1832	6226										
THBS2	7058	broad.mit.edu	37	chr6	169629697	169629697	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcacaccgtcattgtcatcGtcatcatcacaggcatcgcc	7	15	6	0	rs148360643	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:169629697G>A	ENST00000366787.3	-	15	2478	c.2229C>T	c.(2227-2229)gaC>gaT	p.D743D	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	743					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CATTGTCATCGTCATCATCAC	0.547													32	64					0	0	1	0	0	A	169629697	G	A	169629697	2	1	48	1	0	0	0	0	0	0	0	1	15913	1136	40	1		1	THBS2	6	169629697	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1161620	169629697	1485370	1833	6227										
FAM120B	84498	broad.mit.edu	37	chr6	170627407	170627407	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatcttttaccaggacaaaAatctccatggtttttccaaa	4	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr6:170627407A>G	ENST00000476287.1	+	2	1037	c.929A>G	c.(928-930)aAa>aGa	p.K310R	FAM120B_ENST00000540480.1_Missense_Mutation_p.K322R|FAM120B_ENST00000537664.1_Missense_Mutation_p.K333R|FAM120B_ENST00000252510.9_Intron	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	310					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		CCAGGACAAAAATCTCCATGG	0.373													35	69					0	0	1	0	0	G	170627407	A	G	170627407	3	3	48	1	0	0	0	0	1	0	0	0	5448	14	1	4	931	4	FAM120B	6	170627407	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	997710	170627407	487660	1834	6228										
C7orf50	84310	broad.mit.edu	37	chr7	1037352	1037352	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catccagctcccgcatcaggGcttccgccttctgcaccgtc	8	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:1037352G>A	ENST00000397098.3	-	5	1420	c.494C>T	c.(493-495)gCc>gTc	p.A165V	C7orf50_ENST00000397100.2_Missense_Mutation_p.A165V|C7orf50_ENST00000488073.1_5'UTR|C7orf50_ENST00000357429.6_Missense_Mutation_p.A165V			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	165							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		CCGCATCAGGGCTTCCGCCTT	0.677													25	33					0	0	1	0	0	A	1037352	G	A	1037352	3	1	48	1	0	0	0	0	1	0	0	0	2415	1203	42	3	94	3	C7orf50	7	1037352	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		1037352	158101311	1835	6229										
CARD11	84433	broad.mit.edu	37	chr7	2966401	2966401	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaaggcgtcaaacccgccGctgtcattgtcttcttcgac	8	14	5	0	rs138401482		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:2966401G>A	ENST00000396946.4	-	14	2182	c.1779C>T	c.(1777-1779)agC>agT	p.S593S		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	593					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CAAACCCGCCGCTGTCATTGT	0.582			Mis		DLBCL								4	31					0	0	1	0	0	A	2966401	G	A	2966401	2	1	48	1	0	0	0	0	0	0	0	1	2663	1078	38	1		1	CARD11	7	2966401	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1929049	2966401	156172262	1836	6230										
PAPOLB	56903	broad.mit.edu	37	chr7	4901062	4901062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaggtgaaaaagtcgcttCgatccacatgacttggtgca	11	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:4901062C>T	ENST00000404991.1	-	1	563	c.377G>A	c.(376-378)cGa>cAa	p.R126Q	RADIL_ENST00000399583.3_Intron|RADIL_ENST00000536091.1_Intron	NM_020144.4	NP_064529.4	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	126					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			kidney(1)|large_intestine(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		AAAGTCGCTTCGATCCACATG	0.438													13	20					0	0	1	0	0	T	4901062	C	T	4901062	3	4	48	1	0	0	0	0	1	0	0	0	11476	884	31	1	1537	1	PAPOLB	7	4901062	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1934661	4901062	154237601	1837	6231										
SLC29A4	222962	broad.mit.edu	37	chr7	5338985	5338985	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcctcgagtctgagatccGccactgcatcctgggcgagt	13	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:5338985G>A	ENST00000396872.2	+	9	1297	c.1136G>A	c.(1135-1137)cGc>cAc	p.R379H	SLC29A4_ENST00000297195.4_Missense_Mutation_p.R379H|SLC29A4_ENST00000439491.2_3'UTR|SLC29A4_ENST00000406453.3_Missense_Mutation_p.R365H	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	379					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TCTGAGATCCGCCACTGCATC	0.642													7	39					0	0	1	0	0	A	5338985	G	A	5338985	3	1	48	1	0	0	0	0	1	0	0	0	14591	1087	38	1	1166	1	SLC29A4	7	5338985	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	437923	5338985	153799678	1838	6232										
ACTB	60	broad.mit.edu	37	chr7	5568242	5568242	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggcacagtgtgggtgacccCgtcaccggagtccatcacga	14	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:5568242C>T	ENST00000331789.5	-	4	663	c.472G>A	c.(472-474)Ggg>Agg	p.G158R		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	158					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGGGTGACCCCGTCACCGGAG	0.607													42	113					0	0	1	0	0	T	5568242	C	T	5568242	3	4	48	1	0	0	0	0	1	0	0	0	193	652	23	1	667	1	ACTB	7	5568242	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	229257	5568242	153570421	1839	6233										
AIMP2	7965	broad.mit.edu	37	chr7	6054938	6054938	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccaagcggatgagcccacGactttaaccaccaatgcgct	8	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:6054938G>A	ENST00000223029.3	+	2	416	c.297G>A	c.(295-297)acG>acA	p.T99T	AIMP2_ENST00000400479.2_Silent_p.T21T|AIMP2_ENST00000395236.2_Intron	NM_006303.3	NP_006294.2	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	99	Interaction with PARK2.		EPT -> DLS (in a lung cancer cell line; no effect on proapoptotic activity).		apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						ATGAGCCCACGACTTTAACCA	0.463													21	48					0	0	1	0	0	A	6054938	G	A	6054938	2	1	48	1	0	0	0	0	0	0	0	1	431	1045	37	1		1	AIMP2	7	6054938	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	486696	6054938	153083725	1840	6234										
C1GALT1	56913	broad.mit.edu	37	chr7	7273978	7273978	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaaatcctggctgaattttTtaaccttcctctgtggatca	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:7273978T>G	ENST00000436587.2	+	2	251	c.28T>G	c.(28-30)Tta>Gta	p.L10V	C1GALT1_ENST00000402468.3_Missense_Mutation_p.L10V|C1GALT1_ENST00000223122.2_Missense_Mutation_p.L10V	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	10					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		GCTGAATTTTTTAACCTTCCT	0.363													15	28					0	0	1	0	0	G	7273978	T	G	7273978	3	3	48	1	0	0	0	0	1	0	0	0	1965	1838	64	4	30	4	C1GALT1	7	7273978	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1219040	7273978	151864685	1841	6235										
THSD7A	221981	broad.mit.edu	37	chr7	11485733	11485733	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaagcctgccattttgatCgtagcatgccattgcttggt	9	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:11485733C>T	ENST00000423059.3	-	13	3270	c.3019G>A	c.(3019-3021)Gat>Aat	p.D1007N	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1007	TSP type-1 10.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCATTTTGATCGTAGCATGCC	0.423										HNSCC(18;0.044)			59	111					0	0	1	0	0	T	11485733	C	T	11485733	3	4	48	1	0	0	0	0	1	0	0	0	15938	884	31	1	2014	1	THSD7A	7	11485733	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4211755	11485733	147652930	1842	6236										
ARL4A	10124	broad.mit.edu	37	chr7	12728459	12728459	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaaaagaagaaaaatgttgCggcaacagaaaaagaaaaga	9	3	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:12728459C>T	ENST00000396663.1	+	2	1062	c.580C>T	c.(580-582)Cgg>Tgg	p.R194W	ARL4A_ENST00000356797.3_Missense_Mutation_p.R194W|ARL4A_ENST00000404894.1_Missense_Mutation_p.R194W|ARL4A_ENST00000396664.2_Missense_Mutation_p.R194W|ARL4A_ENST00000396662.1_Missense_Mutation_p.R194W	NM_001037164.2|NM_001195396.1|NM_005738.4|NM_212460.3	NP_001032241.1|NP_001182325.1|NP_005729.1|NP_997625.1	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	194					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding			NS(2)|lung(3)|ovary(1)	6				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		AAAAATGTTGCGGCAACAGAA	0.378													18	41					0	0	1	0	0	T	12728459	C	T	12728459	3	4	48	1	0	0	0	0	1	0	0	0	935	759	27	1	582	1	ARL4A	7	12728459	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1242726	12728459	146410204	1843	6237										
ITGB8	3696	broad.mit.edu	37	chr7	20418911	20418911	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaccccgaaaggattcataAtcaatgcaggtatctagggt	9	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:20418911A>C	ENST00000222573.3	+	4	1310	c.626A>C	c.(625-627)aAt>aCt	p.N209T	ITGB8_ENST00000537992.1_Missense_Mutation_p.N74T	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	209	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						AGGATTCATAATCAATGCAGG	0.328													13	19					0	0	1	0	0	C	20418911	A	C	20418911	3	2	48	1	0	0	0	0	1	0	0	0	7944	101	4	4	640	4	ITGB8	7	20418911	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7690452	20418911	138719752	1844	6238										
ABCB5	340273	broad.mit.edu	37	chr7	20685489	20685489	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagcctttagggcccaggaGaaagaacttcaaaggtcttt	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:20685489G>T	ENST00000404938.2	+	8	1441	c.789G>T	c.(787-789)gaG>gaT	p.E263D		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	449	ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GGGCCCAGGAGAAAGAACTTC	0.403													9	102					0.00448238	0.00465112	1	1	0	T	20685489	G	T	20685489	3	4	48	1	0	0	0	0	1	0	0	0	44	933	33	2	815	2	ABCB5	7	20685489	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	266578	20685489	138453174	1845	6239										
DNAH11	8701	broad.mit.edu	37	chr7	21646328	21646328	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcttggatttaatgcagaaAatccatacacagcgcttgat	7	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:21646328A>C	ENST00000328843.6	+	20	3860	c.3829A>C	c.(3829-3831)Aat>Cat	p.N1277H	DNAH11_ENST00000409508.3_Missense_Mutation_p.N1277H			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1277	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TAATGCAGAAAATCCATACAC	0.338									Kartagener syndrome				4	9					0	0	1	0	0	C	21646328	A	C	21646328	3	2	48	1	0	0	0	0	1	0	0	0	4627	14	1	4	3907	4	DNAH11	7	21646328	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	960839	21646328	137492335	1846	6240										
DNAH11	8701	broad.mit.edu	37	chr7	21675657	21675657	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtctgttcagaagatattCgaatccagcttgtgaaagat	9	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:21675657C>T	ENST00000328843.6	+	26	4715	c.4684C>T	c.(4684-4686)Cga>Tga	p.R1562*	DNAH11_ENST00000465593.1_3'UTR|DNAH11_ENST00000409508.3_Nonsense_Mutation_p.R1557*			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1562	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGAAGATATTCGAATCCAGCT	0.388									Kartagener syndrome				4	12					0	0	1	0	0	T	21675657	C	T	21675657	4	4	48	1	0	0	0	0	0	1	0	0	4627	876	31	1	4786	1	DNAH11	7	21675657	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29329	21675657	137463006	1847	6241										
DNAH11	8701	broad.mit.edu	37	chr7	21747358	21747358	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatatgttaacatgaaacaGaagccggtttggaatgactt	9	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:21747358G>A	ENST00000328843.6	+	41	6640	c.6609G>A	c.(6607-6609)caG>caA	p.Q2203Q	DNAH11_ENST00000409508.3_Silent_p.Q2196Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2203	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACATGAAACAGAAGCCGGTTT	0.388									Kartagener syndrome				9	23					0	0	1	0	0	A	21747358	G	A	21747358	2	1	48	1	0	0	0	0	0	0	0	1	4627	933	33	3		3	DNAH11	7	21747358	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	71701	21747358	137391305	1848	6242										
RAPGEF5	9771	broad.mit.edu	37	chr7	22349699	22349699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctaccagctctgacccaaCgcagctcctcctgaacaaaa	6	16	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:22349699C>T	ENST00000405243.1	-	4	483	c.400G>A	c.(400-402)Gtt>Att	p.V134I	RAPGEF5_ENST00000344041.6_5'UTR			Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	0	N-terminal Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TCTGACCCAACGCAGCTCCTC	0.438													6	22					0	0	1	0	0	T	22349699	C	T	22349699	3	4	48	1	0	0	0	0	1	0	0	0	13098	551	19	1		1	RAPGEF5	7	22349699	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	602341	22349699	136788964	1849	6243										
IGF2BP3	10643	broad.mit.edu	37	chr7	23387299	23387299	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgccttcaggagtagagagGatagtaatcgacttctcagc	12	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:23387299G>A	ENST00000258729.3	-	7	1094	c.738C>T	c.(736-738)atC>atT	p.I246I		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	246	KH 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						GAGTAGAGAGGATAGTAATCG	0.458													30	55					0	0	1	0	0	A	23387299	G	A	23387299	2	1	48	1	0	0	0	0	0	0	0	1	7618	1164	41	3		3	IGF2BP3	7	23387299	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1037600	23387299	135751364	1850	6244										
TRA2A	29896	broad.mit.edu	37	chr7	23547091	23547091	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgtgtgcgctctcttggTtatagaataatccacccgaa	10	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:23547091T>C	ENST00000297071.4	-	5	805	c.589A>G	c.(589-591)Acc>Gcc	p.T197A	TRA2A_ENST00000538367.1_Missense_Mutation_p.T96A|TRA2A_ENST00000474586.1_5'UTR|TRA2A_ENST00000392502.4_Missense_Mutation_p.T96A	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)	197	RRM.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						GCTCTCTTGGTTATAGAATAA	0.418													28	72					0	0	1	0	0	C	23547091	T	C	23547091	3	2	48	1	0	0	0	0	1	0	0	0	16493	1725	60	4	275	4	TRA2A	7	23547091	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	159792	23547091	135591572	1851	6245										
TRA2A	29896	broad.mit.edu	37	chr7	23556145	23556145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaatgtctccttgacctcGacctttgagagaaatacatt	8	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:23556145G>A	ENST00000297071.4	-	3	389	c.173C>T	c.(172-174)tCg>tTg	p.S58L	TRA2A_ENST00000538367.1_5'UTR|TRA2A_ENST00000474586.1_5'UTR|TRA2A_ENST00000392502.4_5'UTR	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)	58	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						CCTTGACCTCGACCTTTGAGA	0.398													13	30					0	0	1	0	0	A	23556145	G	A	23556145	3	1	48	1	0	0	0	0	1	0	0	0	16493	1059	37	1	699	1	TRA2A	7	23556145	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9054	23556145	135582518	1852	6246										
STK31	56164	broad.mit.edu	37	chr7	23811882	23811882	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatggaaattggttgaaaaGagtaatttggaagaggtaag	14	0	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:23811882G>T	ENST00000354639.3	+	15	2345	c.1881G>T	c.(1879-1881)aaG>aaT	p.K627N	STK31_ENST00000428484.1_Missense_Mutation_p.K627N|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Missense_Mutation_p.K650N|STK31_ENST00000355870.3_Missense_Mutation_p.K650N	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	650							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGGTTGAAAAGAGTAATTTGG	0.323													21	32					8.10497e-08	9.43176e-08	1	1	0	T	23811882	G	T	23811882	3	4	48	1	0	0	0	0	1	0	0	0	15351	933	33	2	2008	2	STK31	7	23811882	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	255737	23811882	135326781	1853	6247										
STK31	56164	broad.mit.edu	37	chr7	23871984	23871984	+	Nonstop_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaagccaactttgattgttAaattattattgttgttgttg	8	3	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:23871984A>C	ENST00000354639.3	+	24	3454	c.2990A>C	c.(2989-2991)tAa>tCa	p.*997S	STK31_ENST00000428484.1_Nonstop_Mutation_p.*997S|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Nonstop_Mutation_p.*997S|STK31_ENST00000355870.3_Nonstop_Mutation_p.*1020S	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	0	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTGATTGTTAAATTATTATT	0.318													13	30					0	0	1	0	0	C	23871984	A	C	23871984	4	2	48	1	0	0	0	0	0	0	0	0	15351	369	13	4	3153	4	STK31	7	23871984	Nonstop_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	60102	23871984	135266679	1854	6248										
OSBPL3	26031	broad.mit.edu	37	chr7	24846441	24846441	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaggtggcaataaagactTtgatgatggatccatttcat	10	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:24846441T>C	ENST00000313367.2	-	21	2849	c.2398A>G	c.(2398-2400)Aag>Gag	p.K800E	OSBPL3_ENST00000409069.1_Missense_Mutation_p.K733E|OSBPL3_ENST00000396429.1_Missense_Mutation_p.K764E|OSBPL3_ENST00000396431.1_Missense_Mutation_p.K769E|OSBPL3_ENST00000431825.2_Missense_Mutation_p.K733E|OSBPL3_ENST00000353930.1_Missense_Mutation_p.K764E|OSBPL3_ENST00000487020.1_Intron|OSBPL3_ENST00000352860.1_Missense_Mutation_p.K769E	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	800					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						AATAAAGACTTTGATGATGGA	0.368													20	54					0	0	1	0	0	C	24846441	T	C	24846441	3	2	48	1	0	0	0	0	1	0	0	0	11325	1850	64	4	277	4	OSBPL3	7	24846441	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	974457	24846441	134292222	1855	6249										
HOXA9	3205	broad.mit.edu	37	chr7	27203258	27203258	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtctttgttgattttcttCattttcatcctgcggttctg	8	9	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:27203258C>A	ENST00000343483.6	-	2	855	c.783G>T	c.(781-783)atG>atT	p.M261I	RP1-170O19.20_ENST00000470747.4_Missense_Mutation_p.M101I|HOXA9_ENST00000497089.1_5'UTR|HOXA9_ENST00000396345.1_3'UTR	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	261							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						TGATTTTCTTCATTTTCATCC	0.483			T	"NUP98, MSI2"	AML*								50	94					1.21353e-23	1.69828e-23	1	1	0	A	27203258	C	A	27203258	3	1	48	1	0	0	0	0	1	0	0	0	7338	826	29	2	39	2	HOXA9	7	27203258	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2356817	27203258	131935405	1856	6250										
EVX1	2128	broad.mit.edu	37	chr7	27282795	27282795	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgccccgtggttgcctgaGccctcgggccgtccctccgg	15	17	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:27282795G>A	ENST00000496902.4	+	1	632	c.146G>A	c.(145-147)aGc>aAc	p.S49N	EVX1_ENST00000222761.3_Missense_Mutation_p.S49N|EVX1-AS_ENST00000517726.1_RNA|EVX1-AS_ENST00000519218.1_RNA			P49640	EVX1_HUMAN	even-skipped homeobox 1	49						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|liver(1)|lung(10)|prostate(1)|skin(1)	14						GGTTGCCTGAGCCCTCGGGCC	0.726													6	10					0	0	1	0	0	A	27282795	G	A	27282795	3	1	48	1	0	0	0	0	1	0	0	0	5321	971	34	3	148	3	EVX1	7	27282795	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	79537	27282795	131855868	1857	6251										
HIBADH	11112	broad.mit.edu	37	chr7	27582659	27582659	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaactcttgggcagcagcaAattcatcttcaactcctccc	6	15	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:27582659A>C	ENST00000265395.2	-	5	751	c.545T>G	c.(544-546)tTt>tGt	p.F182C		NM_152740.3	NP_689953.1	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase	182					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(4)|kidney(2)|lung(3)|ovary(2)|prostate(1)	12			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	GGCAGCAGCAAATTCATCTTC	0.483													9	41					0	0	1	0	0	C	27582659	A	C	27582659	3	2	48	1	0	0	0	0	1	0	0	0	7139	14	1	4	481	4	HIBADH	7	27582659	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	299864	27582659	131556004	1858	6252										
JAZF1	221895	broad.mit.edu	37	chr7	27935032	27935032	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcgggcagcatctgtcatGaatctgaaacaataatggaa	11	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:27935032G>T	ENST00000283928.5	-	3	357	c.192C>A	c.(190-192)ttC>ttA	p.F64L		NM_175061.3	NP_778231.2	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	64					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(133)	endometrium(1)|large_intestine(1)|lung(4)	6						CATCTGTCATGAATCTGAAAC	0.483			T	SUZ12	endometrial stromal tumours								17	43					4.14922e-12	5.21015e-12	1	1	0	T	27935032	G	T	27935032	3	4	48	1	0	0	0	0	1	0	0	0	7989	1281	45	2	551	2	JAZF1	7	27935032	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	352373	27935032	131203631	1859	6253										
CPVL	54504	broad.mit.edu	37	chr7	29111427	29111427	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttctgcttcctgatgtgttCtatgcattcatggcactgct	9	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:29111427C>A	ENST00000409850.1	-	13	1472	c.826G>T	c.(826-828)Gaa>Taa	p.E276*	CPVL_ENST00000396276.3_Nonsense_Mutation_p.E276*|CPVL_ENST00000265394.5_Nonsense_Mutation_p.E276*			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	276					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						CTGATGTGTTCTATGCATTCA	0.488													8	97					0.000157383	0.000169016	1	1	0	A	29111427	C	A	29111427	4	1	48	1	0	0	0	0	0	1	0	0	3858	922	32	2	624	2	CPVL	7	29111427	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1176395	29111427	130027236	1860	6254										
CPVL	54504	broad.mit.edu	37	chr7	29111954	29111954	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccatctccaatagcaattCcgttcaggttgatcttcacc	5	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:29111954C>T	ENST00000409850.1	-	12	1341	c.695G>A	c.(694-696)gGa>gAa	p.G232E	CPVL_ENST00000396276.3_Missense_Mutation_p.G232E|CPVL_ENST00000265394.5_Missense_Mutation_p.G232E			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	232					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						AATAGCAATTCCGTTCAGGTT	0.433													20	35					0	0	1	0	0	T	29111954	C	T	29111954	3	4	48	1	0	0	0	0	1	0	0	0	3858	855	30	3	759	3	CPVL	7	29111954	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	527	29111954	130026709	1861	6255										
CCDC129	223075	broad.mit.edu	37	chr7	31617627	31617627	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtgccgccaaagagcatcGaagaagaatgggtaaactct	12	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:31617627G>A	ENST00000409210.1	+	6	657	c.473G>A	c.(472-474)cGa>cAa	p.R158Q	CCDC129_ENST00000319386.3_Intron|CCDC129_ENST00000407970.3_Missense_Mutation_p.R250Q|CCDC129_ENST00000451887.2_Missense_Mutation_p.R276Q			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	250										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						AAAGAGCATCGAAGAAGAATG	0.483													10	24					0	0	1	0	0	A	31617627	G	A	31617627	3	1	48	1	0	0	0	0	1	0	0	0	2782	1058	37	1	775	1	CCDC129	7	31617627	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2505673	31617627	127521036	1862	6256										
CCDC129	223075	broad.mit.edu	37	chr7	31617807	31617807	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacaagcaaaatcatttgtCtctgtcagtagaacatcagt	6	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:31617807C>A	ENST00000409210.1	+	6	837	c.653C>A	c.(652-654)tCt>tAt	p.S218Y	CCDC129_ENST00000319386.3_Intron|CCDC129_ENST00000407970.3_Missense_Mutation_p.S310Y|CCDC129_ENST00000451887.2_Missense_Mutation_p.S336Y			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	310										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						AATCATTTGTCTCTGTCAGTA	0.453													23	14					3.8784e-16	5.13982e-16	1	1	0	A	31617807	C	A	31617807	3	1	48	1	0	0	0	0	1	0	0	0	2782	913	32	2	955	2	CCDC129	7	31617807	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	180	31617807	127520856	1863	6257										
CCDC129	223075	broad.mit.edu	37	chr7	31692174	31692174	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccacctgaacactattcaAatctgcatcaatataactgg	5	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:31692174A>C	ENST00000319386.3	+	14	3415	c.2422A>C	c.(2422-2424)Aat>Cat	p.N808H	CCDC129_ENST00000409210.1_Missense_Mutation_p.N864H|CCDC129_ENST00000407970.3_Missense_Mutation_p.N956H|CCDC129_ENST00000451887.2_Missense_Mutation_p.N982H			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	956	Cys-rich.									cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						ACACTATTCAAATCTGCATCA	0.458													5	9					0	0	1	0	0	C	31692174	A	C	31692174	3	2	48	1	0	0	0	0	1	0	0	0	2782	14	1	4	2916	4	CCDC129	7	31692174	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	74367	31692174	127446489	1864	6258										
PDE1C	5137	broad.mit.edu	37	chr7	31848655	31848655	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atactcttaccatctgttttCtttgaatcatttccgatgtt	4	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:31848655C>A	ENST00000396184.3	-	17	2085	c.1881G>T	c.(1879-1881)aaG>aaT	p.K627N	PDE1C_ENST00000321453.7_Missense_Mutation_p.K627N|PDE1C_ENST00000396191.1_Missense_Mutation_p.K627N|PDE1C_ENST00000396193.1_Missense_Mutation_p.K687N|PDE1C_ENST00000396182.2_Missense_Mutation_p.K627N|PDE1C_ENST00000479980.1_5'UTR	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	627					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CATCTGTTTTCTTTGAATCAT	0.303													3	14					0.115264	0.116507	1	1	0	A	31848655	C	A	31848655	3	1	48	1	0	0	0	0	1	0	0	0	11681	912	32	2	31	2	PDE1C	7	31848655	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	156481	31848655	127290008	1865	6259										
LSM5	0	broad.mit.edu	37	chr7	32526906	32526906	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttctcctccaggaaccagCtgcataaagaggaaaaagag	9	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:32526906C>T	ENST00000450169.2	-	5	296		c.e5-1		LSM5_ENST00000409987.1_Splice_Site|LSM5_ENST00000409782.1_Splice_Site|LSM5_ENST00000409952.3_Splice_Site|LSM5_ENST00000409909.3_Splice_Site|LSM5_ENST00000410044.1_Splice_Site|LSM5_ENST00000409292.1_Splice_Site	NM_001130710.1|NM_012322.2	NP_001124182.1|NP_036454.1	Q9Y4Y9	LSM5_HUMAN	LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding			breast(1)|cervix(1)|large_intestine(1)|lung(1)|stomach(1)	5			GBM - Glioblastoma multiforme(11;0.152)			CAGGAACCAGCTGCATAAAGA	0.393													13	12					0	0	1	0	0	T	32526906	C	T	32526906	5	4	48	1	0	0	0	0	0	0	1	0	9103	811	28	3	36	3	LSM5	7	32526906	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	678251	32526906	126611757	1866	6260										
NPSR1	387129	broad.mit.edu	37	chr7	34888160	34888160	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaatttcaacctccttccaGacacccaggagcgtttctat	5	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:34888160G>A	ENST00000360581.1	+	8	1038	c.910G>A	c.(910-912)Gac>Aac	p.D304N	NPSR1_ENST00000381539.3_Missense_Mutation_p.D304N|NPSR1_ENST00000359791.1_Missense_Mutation_p.D304N|NPSR1_ENST00000531252.1_Missense_Mutation_p.D293N|NPSR1_ENST00000381542.1_Missense_Mutation_p.D238N	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	304						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CCTCCTTCCAGACACCCAGGA	0.493													84	150					0	0	1	0	0	A	34888160	G	A	34888160	3	1	48	1	0	0	0	0	1	0	0	0	10647	942	33	3	940	3	NPSR1	7	34888160	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2361254	34888160	124250503	1867	6261										
ANLN	54443	broad.mit.edu	37	chr7	36459027	36459027	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaacaggaagatgcactgaAtatctcctcaatgtctttac	7	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:36459027A>C	ENST00000265748.2	+	10	2029	c.1808A>C	c.(1807-1809)aAt>aCt	p.N603T	ANLN_ENST00000396068.2_Missense_Mutation_p.N566T	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	603	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						GATGCACTGAATATCTCCTCA	0.443													29	32					0	0	1	0	0	C	36459027	A	C	36459027	3	2	48	1	0	0	0	0	1	0	0	0	688	101	4	4	1846	4	ANLN	7	36459027	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1570867	36459027	122679636	1868	6262										
ELMO1	9844	broad.mit.edu	37	chr7	37264564	37264564	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatggctattgagcaccatCgactccaaaatggccaagga	9	11	1	1	rs148167670		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:37264564C>T	ENST00000310758.4	-	9	1268	c.621G>A	c.(619-621)tcG>tcA	p.S207S	ELMO1_ENST00000442504.1_Silent_p.S207S|ELMO1_ENST00000448602.1_Silent_p.S207S	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	207					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding	p.S207S(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TGAGCACCATCGACTCCAAAA	0.502													21	41					0	0	1	0	0	T	37264564	C	T	37264564	2	4	48	1	0	0	0	0	0	0	0	1	5093	871	31	1		1	ELMO1	7	37264564	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	805537	37264564	121874099	1869	6263										
AMPH	273	broad.mit.edu	37	chr7	38431504	38431504	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctcgctggtggggcccgGaggagccgcgtcctcggtgg	19	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:38431504G>A	ENST00000356264.2	-	19	1938	c.1723C>T	c.(1723-1725)Ccg>Tcg	p.P575S	AMPH_ENST00000325590.5_Missense_Mutation_p.P533S|AMPH_ENST00000428293.2_Missense_Mutation_p.P533S	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	575					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane		p.P575S(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						GTGGGGCCCGGAGGAGCCGCG	0.612													24	36					0	0	1	0	0	A	38431504	G	A	38431504	3	1	48	1	0	0	0	0	1	0	0	0	584	1174	41	3	376	3	AMPH	7	38431504	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1166940	38431504	120707159	1870	6264										
C7orf10	79783	broad.mit.edu	37	chr7	40899972	40899972	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccaggccgcccccgctgcTcgggcagcacacaacgcaca	12	19	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:40899972T>C	ENST00000309930.5	+	15	1334	c.1310T>C	c.(1309-1311)cTc>cCc	p.L437P	C7orf10_ENST00000464028.1_3'UTR|C7orf10_ENST00000401647.2_Missense_Mutation_p.L363P|C7orf10_ENST00000335693.4_Missense_Mutation_p.L411P	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	411							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						CCCCCGCTGCTCGGGCAGCAC	0.567													43	96					0	0	1	0	0	C	40899972	T	C	40899972	3	2	48	1	0	0	0	0	1	0	0	0	2392	1551	54	4	1257	4	C7orf10	7	40899972	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2468468	40899972	118238691	1871	6265										
GLI3	2737	broad.mit.edu	37	chr7	42005605	42005605	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctgaggctgctgaagcgCggcacacgaggcagggccag	17	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:42005605C>T	ENST00000395925.3	-	15	3150	c.3066G>A	c.(3064-3066)ccG>ccA	p.P1022P	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1022					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TGCTGAAGCGCGGCACACGAG	0.736									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				12	19					0	0	1	0	0	T	42005605	C	T	42005605	2	4	48	1	0	0	0	0	0	0	0	1	6480	755	27	1		1	GLI3	7	42005605	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1105633	42005605	117133058	1872	6266										
GLI3	2737	broad.mit.edu	37	chr7	42116368	42116368	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacatatgcaatggaggaatCggagatggatcgtaatggta	13	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:42116368C>T	ENST00000395925.3	-	4	540	c.456G>A	c.(454-456)ccG>ccA	p.P152P	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	152					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						ATGGAGGAATCGGAGATGGAT	0.423									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				23	29					0	0	1	0	0	T	42116368	C	T	42116368	2	4	48	1	0	0	0	0	0	0	0	1	6480	871	31	1		1	GLI3	7	42116368	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	110763	42116368	117022295	1873	6267										
POLD2	5425	broad.mit.edu	37	chr7	44154947	44154947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccacaaaagtagacatgcGggcactctgggaagatgaac	12	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:44154947G>A	ENST00000406581.2	-	11	1845	c.1196C>T	c.(1195-1197)cCg>cTg	p.P399L	POLD2_ENST00000452185.1_Missense_Mutation_p.P399L|POLD2_ENST00000223361.3_Missense_Mutation_p.P385L	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	399					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding	p.P399Q(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						GTAGACATGCGGGCACTCTGG	0.532													47	65					0	0	1	0	0	A	44154947	G	A	44154947	3	1	48	1	0	0	0	0	1	0	0	0	12238	1116	39	1	221	1	POLD2	7	44154947	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2038579	44154947	114983716	1874	6268										
OGDH	4967	broad.mit.edu	37	chr7	44739760	44739760	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccttaaagaagccaacttCgacatcaatcagctatatga	6	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:44739760C>T	ENST00000222673.5	+	19	2493	c.2451C>T	c.(2449-2451)ttC>ttT	p.F817F	OGDH_ENST00000439616.2_Silent_p.F667F|OGDH_ENST00000543843.1_Silent_p.F768F|OGDH_ENST00000449767.1_Silent_p.F813F|OGDH_ENST00000447398.1_Silent_p.F828F|OGDH_ENST00000444676.1_Silent_p.F832F	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	817					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	AAGCCAACTTCGACATCAATC	0.542													54	100					0	0	1	0	0	T	44739760	C	T	44739760	2	4	48	1	0	0	0	0	0	0	0	1	10886	883	31	1		1	OGDH	7	44739760	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	584813	44739760	114398903	1875	6269										
ABCA13	154664	broad.mit.edu	37	chr7	48315509	48315509	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacacctgctttctgaaatGaacaaaggaatcaaaagtat	7	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:48315509G>T	ENST00000435803.1	+	17	6270	c.6246G>T	c.(6244-6246)atG>atT	p.M2082I		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2082					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTTCTGAAATGAACAAAGGAA	0.368													6	37					0.0477658	0.0484551	1	1	0	T	48315509	G	T	48315509	3	4	48	1	0	0	0	0	1	0	0	0	31	1290	45	2	6141	2	ABCA13	7	48315509	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3575749	48315509	110823154	1876	6270										
ZPBP	11055	broad.mit.edu	37	chr7	50129291	50129291	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgaaaagctcttggtaatcGaaccaagtgtccaactatca	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:50129291G>A	ENST00000046087.2	-	2	211	c.142C>T	c.(142-144)Cga>Tga	p.R48*	ZPBP_ENST00000419417.1_Nonsense_Mutation_p.R48*	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	48					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					CTTGGTAATCGAACCAAGTGT	0.284													5	11					0	0	1	0	0	A	50129291	G	A	50129291	4	1	48	1	0	0	0	0	0	1	0	0	18260	1066	37	1	941	1	ZPBP	7	50129291	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1813782	50129291	109009372	1877	6271										
FIGNL1	63979	broad.mit.edu	37	chr7	50513646	50513646	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacttgccaattagagttTtaccagtcccaggaggacca	9	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:50513646T>G	ENST00000419119.1	-	2	2893	c.1340A>C	c.(1339-1341)aAa>aCa	p.K447T	FIGNL1_ENST00000356889.4_Missense_Mutation_p.K447T|FIGNL1_ENST00000433017.1_Missense_Mutation_p.K447T|FIGNL1_ENST00000395556.2_Missense_Mutation_p.K447T			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	447					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AATTAGAGTTTTACCAGTCCC	0.458													19	24					0	0	1	0	0	G	50513646	T	G	50513646	3	3	48	1	0	0	0	0	1	0	0	0	5924	1841	64	4	688	4	FIGNL1	7	50513646	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	384355	50513646	108625017	1878	6272										
FIGNL1	63979	broad.mit.edu	37	chr7	50514215	50514215	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaaccataaaaagacttCctctgtggattttcacaggc	7	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:50514215C>A	ENST00000419119.1	-	2	2324	c.771G>T	c.(769-771)agG>agT	p.R257S	FIGNL1_ENST00000356889.4_Missense_Mutation_p.R257S|FIGNL1_ENST00000433017.1_Missense_Mutation_p.R257S|FIGNL1_ENST00000395556.2_Missense_Mutation_p.R257S			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	257					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AAAAAGACTTCCTCTGTGGAT	0.388													5	59					0.014758	0.015099	1	1	0	A	50514215	C	A	50514215	3	1	48	1	0	0	0	0	1	0	0	0	5924	854	30	2	1257	2	FIGNL1	7	50514215	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	569	50514215	108624448	1879	6273										
COBL	23242	broad.mit.edu	37	chr7	51111094	51111094	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcacctcagatgtgagttCtcagagccattcttctccca	6	14	5	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:51111094C>A	ENST00000395542.2	-	10	1822	c.1638G>T	c.(1636-1638)gaG>gaT	p.E546D	COBL_ENST00000265136.7_Missense_Mutation_p.E464D			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	464										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GATGTGAGTTCTCAGAGCCAT	0.562													7	64					0.00198382	0.00207034	1	1	0	A	51111094	C	A	51111094	3	1	48	1	0	0	0	0	1	0	0	0	3676	912	32	2	2417	2	COBL	7	51111094	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	596879	51111094	108027569	1880	6274										
SEPT14	346288	broad.mit.edu	37	chr7	55873084	55873084	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcaaagatttcttgaaaaCtaaagagaaatgttttctta	5	5	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:55873084C>A	ENST00000388975.3	-	9	1103		c.e9-1			NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14						cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTCTTGAAAACTAAAGAGAAA	0.398													4	11					0.00909568	0.00935351	1	1	0	A	55873084	C	A	55873084	5	1	48	1	0	0	0	0	0	0	1	0	14116	579	20	5	320	5	SEPT14	7	55873084	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4761990	55873084	103265579	1881	6275										
ZNF479	90827	broad.mit.edu	37	chr7	57188340	57188340	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctccagtatgagttCtcttatgtctagtaaggttt	8	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:57188340C>A	ENST00000331162.4	-	5	1052	c.782G>T	c.(781-783)aGa>aTa	p.R261I		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAGTTCTCTTATGTCT	0.423													18	21					5.01169e-05	5.45927e-05	1	1	0	A	57188340	C	A	57188340	3	1	48	1	0	0	0	0	1	0	0	0	17989	913	32	2	796	2	ZNF479	7	57188340	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1315256	57188340	101950323	1882	6276										
ZNF680	340252	broad.mit.edu	37	chr7	63982090	63982090	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttcacatttgtagggttTctctccagtatgaattttct	6	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:63982090T>C	ENST00000309683.6	-	4	1193	c.1042A>G	c.(1042-1044)Aaa>Gaa	p.K348E		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				TTGTAGGGTTTCTCTCCAGTA	0.343													11	44					0	0	1	0	0	C	63982090	T	C	63982090	3	2	48	1	0	0	0	0	1	0	0	0	18142	1792	62	4	554	4	ZNF680	7	63982090	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	6793750	63982090	95156573	1883	6277										
ZNF680	340252	broad.mit.edu	37	chr7	63982573	63982573	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgcaaaatgatttgccacAttctttacatttgaaaacct	4	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:63982573A>C	ENST00000309683.6	-	4	710	c.559T>G	c.(559-561)Tgt>Ggt	p.C187G	ZNF680_ENST00000476563.1_5'UTR	NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				GATTTGCCACATTCTTTACAT	0.294													9	16					0	0	1	0	0	C	63982573	A	C	63982573	3	2	48	1	0	0	0	0	1	0	0	0	18142	217	8	4	1037	4	ZNF680	7	63982573	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	483	63982573	95156090	1884	6278										
TPST1	8460	broad.mit.edu	37	chr7	65705768	65705768	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgtggtcacggtcaagtaAagagaagatccgcctggatg	14	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:65705768A>G	ENST00000304842.5	+	2	781	c.356A>G	c.(355-357)aAa>aGa	p.K119R	TPST1_ENST00000480281.1_Intron	NM_003596.3	NP_003587.1	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	119					inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						CGGTCAAGTAAAGAGAAGATC	0.522													25	41					0	0	1	0	0	G	65705768	A	G	65705768	3	3	48	1	0	0	0	0	1	0	0	0	16487	14	1	4	358	4	TPST1	7	65705768	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1723195	65705768	93432895	1885	6279										
AUTS2	26053	broad.mit.edu	37	chr7	70227923	70227923	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagggccgattgtccccaaGatatcgggtctagagagaag	14	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:70227923G>T	ENST00000342771.4	+	7	1131	c.810G>T	c.(808-810)aaG>aaT	p.K270N	AUTS2_ENST00000406775.2_Missense_Mutation_p.K270N	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	270										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TTGTCCCCAAGATATCGGGTC	0.547													80	144					9.59377e-39	1.38358e-38	1	1	0	T	70227923	G	T	70227923	3	4	48	1	0	0	0	0	1	0	0	0	1223	933	33	2	981	2	AUTS2	7	70227923	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4522155	70227923	88910740	1886	6280										
WBSCR17	64409	broad.mit.edu	37	chr7	70881033	70881033	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttctttgatgcccacgtgGaattcaccgctggctggtag	12	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:70881033G>A	ENST00000333538.5	+	4	1382	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	250	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TGCCCACGTGGAATTCACCGC	0.567													18	45					0	0	1	0	0	A	70881033	G	A	70881033	3	1	48	1	0	0	0	0	1	0	0	0	17323	1175	41	3	762	3	WBSCR17	7	70881033	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	653110	70881033	88257630	1887	6281										
WBSCR17	64409	broad.mit.edu	37	chr7	70885996	70885996	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgaggtgcagcggtacgaGaactcggcccacgggtacag	15	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:70885996G>T	ENST00000333538.5	+	5	1501	c.867G>T	c.(865-867)gaG>gaT	p.E289D	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	289						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AGCGGTACGAGAACTCGGCCC	0.582													55	118					7.34454e-26	1.03635e-25	1	1	0	T	70885996	G	T	70885996	3	4	48	1	0	0	0	0	1	0	0	0	17323	933	33	2	885	2	WBSCR17	7	70885996	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4963	70885996	88252667	1888	6282										
TRIM50	135892	broad.mit.edu	37	chr7	72733015	72733015	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggtgcagctcctggaactCgcggcggatcacccagctga	14	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:72733015C>T	ENST00000333149.2	-	4	732	c.532G>A	c.(532-534)Gag>Aag	p.E178K	TRIM50_ENST00000453152.1_Missense_Mutation_p.E178K	NM_178125.2	NP_835226.1	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	178						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						TCCTGGAACTCGCGGCGGATC	0.652													37	102					0	0	1	0	0	T	72733015	C	T	72733015	3	4	48	1	0	0	0	0	1	0	0	0	16586	893	31	1	947	1	TRIM50	7	72733015	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1847019	72733015	86405648	1889	6283										
FZD9	8326	broad.mit.edu	37	chr7	72849234	72849234	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcctgtgaccaggaggcgggCgcgctctacgtgatccagga	16	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:72849234C>T	ENST00000344575.3	+	1	1126	c.897C>T	c.(895-897)ggC>ggT	p.G299G		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	299					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGAGGCGGGCGCGCTCTACG	0.637													50	83					0	0	1	0	0	T	72849234	C	T	72849234	2	4	48	1	0	0	0	0	0	0	0	1	6171	755	27	1		1	FZD9	7	72849234	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	116219	72849234	86289429	1890	6284										
NCF1	653361	broad.mit.edu	37	chr7	74197898	74197898	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtcagatgaaagcaaagcGaggctggatcccagcgtcct	12	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:74197898G>T	ENST00000289473.4	+	7	675	c.605G>T	c.(604-606)cGa>cTa	p.R202L	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	202	SH3 1.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						AAAGCAAAGCGAGGCTGGATC	0.637													15	35					4.14922e-12	5.21015e-12	1	1	0	T	74197898	G	T	74197898	3	4	48	1	0	0	0	0	1	0	0	0	10262	1058	37	2	631	2	NCF1	7	74197898	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1348664	74197898	84940765	1891	6285										
PTPN12	0	broad.mit.edu	37	chr7	77166889	77166889	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaagtggagatcctgaggaAattcatccagagggtccagg	14	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:77166889A>C	ENST00000248594.6	+	1	298	c.26A>C	c.(25-27)aAa>aCa	p.K9T		NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	9						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						ATCCTGAGGAAATTCATCCAG	0.667													8	14					0	0	1	0	0	C	77166889	A	C	77166889	3	2	48	1	0	0	0	0	1	0	0	0	12830	14	1	4	28	4	PTPN12	7	77166889	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2968991	77166889	81971774	1892	6286										
PTPN12	0	broad.mit.edu	37	chr7	77230000	77230000	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaatctcgtaggctgtatcAgtttcattatgtgaactggc	11	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:77230000A>C	ENST00000248594.6	+	8	844	c.572A>C	c.(571-573)cAg>cCg	p.Q191P	PTPN12_ENST00000415482.2_Missense_Mutation_p.Q72P|PTPN12_ENST00000435495.2_Missense_Mutation_p.Q61P	NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	191	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						AGGCTGTATCAGTTTCATTAT	0.338													3	13					0	0	1	0	0	C	77230000	A	C	77230000	3	2	48	1	0	0	0	0	1	0	0	0	12830	188	7	4	602	4	PTPN12	7	77230000	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	63111	77230000	81908663	1893	6287										
RSBN1L	222194	broad.mit.edu	37	chr7	77378805	77378805	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaaggtaaagaagaaaaaGaaaaagaaacacaaagagaa	8	2	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:77378805G>T	ENST00000334955.7	+	3	795	c.768G>T	c.(766-768)aaG>aaT	p.K256N	RSBN1L_ENST00000445288.1_5'UTR	NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	256	Lys-rich.					nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGAAGAAAAAGAAAAAGAAAC	0.323													11	17					6.40141e-05	6.95424e-05	1	1	0	T	77378805	G	T	77378805	3	4	48	1	0	0	0	0	1	0	0	0	13748	933	33	2	778	2	RSBN1L	7	77378805	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	148805	77378805	81759858	1894	6288										
PHTF2	57157	broad.mit.edu	37	chr7	77579062	77579062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attggtaatctggtgcatctCgttaacactttttctcctaa	6	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:77579062C>T	ENST00000416283.2	+	15	2051	c.1925C>T	c.(1924-1926)tCg>tTg	p.S642L	PHTF2_ENST00000275575.7_Intron|PHTF2_ENST00000248550.7_Missense_Mutation_p.S676L|PHTF2_ENST00000422959.2_Missense_Mutation_p.S642L|PHTF2_ENST00000307305.8_Missense_Mutation_p.S638L	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	676					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						TGGTGCATCTCGTTAACACTT	0.353													5	7					0	0	1	0	0	T	77579062	C	T	77579062	3	4	48	1	0	0	0	0	1	0	0	0	11910	893	31	1	2037	1	PHTF2	7	77579062	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	200257	77579062	81559601	1895	6289										
MAGI2	9863	broad.mit.edu	37	chr7	77885413	77885413	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggcatccctgaatgtcaaGtatttgtttcacccgctgtc	9	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:77885413G>T	ENST00000354212.4	-	10	2147	c.1894C>A	c.(1894-1896)Ctt>Att	p.L632I	MAGI2_ENST00000535697.1_Missense_Mutation_p.L469I|MAGI2_ENST00000419488.1_Missense_Mutation_p.L632I|MAGI2_ENST00000522391.1_Missense_Mutation_p.L632I|MAGI2_ENST00000536571.1_Missense_Mutation_p.L464I	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	632	PDZ 3.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGAATGTCAAGTATTTGTTTC	0.493													11	15					0.000673444	0.000709932	1	1	0	T	77885413	G	T	77885413	3	4	48	1	0	0	0	0	1	0	0	0	9240	1029	36	5	2525	5	MAGI2	7	77885413	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	306351	77885413	81253250	1896	6290										
CACNA2D1	781	broad.mit.edu	37	chr7	81662189	81662189	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgtgaatagcataataatcTtattgcagtttgctctggaa	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:81662189T>G	ENST00000356860.3	-	12	1405	c.1067A>C	c.(1066-1068)aAg>aCg	p.K356T	CACNA2D1_ENST00000464354.1_5'UTR|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.K356T	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	356	VWFA.					voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CATAATAATCTTATTGCAGTT	0.279													4	30					0	0	1	0	0	G	81662189	T	G	81662189	3	3	48	1	0	0	0	0	1	0	0	0	2566	1609	56	4	2320	4	CACNA2D1	7	81662189	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3776776	81662189	77476474	1897	6291										
CACNA2D1	781	broad.mit.edu	37	chr7	81978960	81978960	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatcttatccacccatgatTtgatactgcagaaatcagaa	6	10	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:81978960T>G	ENST00000356860.3	-	2	439	c.101A>C	c.(100-102)aAa>aCa	p.K34T	CACNA2D1_ENST00000423588.1_Missense_Mutation_p.K34T|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.K34T	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	34						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CACCCATGATTTGATACTGCA	0.363													8	47					0	0	1	0	0	G	81978960	T	G	81978960	3	3	48	1	0	0	0	0	1	0	0	0	2566	1841	64	4	3326	4	CACNA2D1	7	81978960	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	316771	81978960	77159703	1898	6292										
PCLO	27445	broad.mit.edu	37	chr7	82538315	82538315	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaccaatctgtttcctcacGacgcagatgataggctttgg	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:82538315G>A	ENST00000423517.2	-	8	13652	c.13315C>T	c.(13315-13317)Cgt>Tgt	p.R4439C	PCLO_ENST00000333891.8_Missense_Mutation_p.R4439C	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4370	PDZ.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTTTCCTCACGACGCAGATGA	0.458													13	23					0	0	1	0	0	A	82538315	G	A	82538315	3	1	48	1	0	0	0	0	1	0	0	0	11629	1058	37	1	2202	1	PCLO	7	82538315	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	559355	82538315	76600348	1899	6293										
PCLO	27445	broad.mit.edu	37	chr7	82544538	82544538	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccaagagaagatcccataAatttttgttggtctgtaata	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:82544538A>C	ENST00000423517.2	-	7	13101	c.12764T>G	c.(12763-12765)tTt>tGt	p.F4255C	PCLO_ENST00000333891.8_Missense_Mutation_p.F4255C|PCLO_ENST00000437081.1_Missense_Mutation_p.F975C	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4186	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGATCCCATAAATTTTTGTTG	0.458													8	19					0	0	1	0	0	C	82544538	A	C	82544538	3	2	48	1	0	0	0	0	1	0	0	0	11629	14	1	4	2757	4	PCLO	7	82544538	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6223	82544538	76594125	1900	6294										
SEMA3E	9723	broad.mit.edu	37	chr7	82996969	82996969	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacggagcttcttttcctgaGggttggcatacttccacttg	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:82996969G>T	ENST00000307792.3	-	17	2728	c.2261C>A	c.(2260-2262)cCt>cAt	p.P754H	SEMA3E_ENST00000427262.1_Missense_Mutation_p.P694H	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	754	Arg/Lys-rich (basic).				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				CTTTTCCTGAGGGTTGGCATA	0.473													40	109					2.40579e-17	3.22781e-17	1	1	0	T	82996969	G	T	82996969	3	4	48	1	0	0	0	0	1	0	0	0	14081	1000	35	5	70	5	SEMA3E	7	82996969	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	452431	82996969	76141694	1901	6295										
SEMA3E	9723	broad.mit.edu	37	chr7	83014659	83014659	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtacaaaccagataactttcGcttgtaaagatcgtggggta	10	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:83014659G>A	ENST00000307792.3	-	16	2293	c.1826C>T	c.(1825-1827)gCg>gTg	p.A609V	SEMA3E_ENST00000427262.1_Missense_Mutation_p.A549V	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	609	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GATAACTTTCGCTTGTAAAGA	0.398													39	59					0	0	1	0	0	A	83014659	G	A	83014659	3	1	48	1	0	0	0	0	1	0	0	0	14081	1087	38	1	509	1	SEMA3E	7	83014659	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17690	83014659	76124004	1902	6296										
SEMA3A	10371	broad.mit.edu	37	chr7	83590853	83590853	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcacagaactcatccattGtgttgagattggggtggttg	13	6	2	2	rs138952094		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:83590853G>A	ENST00000265362.3	-	17	2464	c.2150C>T	c.(2149-2151)aCa>aTa	p.T717I	SEMA3A_ENST00000436949.1_Missense_Mutation_p.T717I	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	717					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CTCATCCATTGTGTTGAGATT	0.468													37	55					0	0	1	0	0	A	83590853	G	A	83590853	3	1	48	1	0	0	0	0	1	0	0	0	14077	1377	48	3	169	3	SEMA3A	7	83590853	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	576194	83590853	75547810	1903	6297										
SEMA3A	10371	broad.mit.edu	37	chr7	83823879	83823879	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatactccccagaaaagacaGacaatcctagttaaccagcc	5	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:83823879G>A	ENST00000265362.3	-	1	338	c.24C>T	c.(22-24)gtC>gtT	p.V8V	SEMA3A_ENST00000436949.1_Silent_p.V8V	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	8					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						AGAAAAGACAGACAATCCTAG	0.428													41	69					0	0	1	0	0	A	83823879	G	A	83823879	2	1	48	1	0	0	0	0	0	0	0	1	14077	929	33	3		3	SEMA3A	7	83823879	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	233026	83823879	75314784	1904	6298										
ABCB4	5244	broad.mit.edu	37	chr7	87035618	87035618	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttacgtggggtaacgtctCgatgaaaggatgtatgttgg	14	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:87035618C>T	ENST00000265723.4	-	26	3604	c.3493G>A	c.(3493-3495)Gag>Aag	p.E1165K	ABCB4_ENST00000453593.1_Missense_Mutation_p.E1111K|ABCB4_ENST00000358400.3_Missense_Mutation_p.E1111K|ABCB4_ENST00000359206.3_Missense_Mutation_p.E1158K|ABCB4_ENST00000545634.1_Missense_Mutation_p.E1158K	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1165	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GGTAACGTCTCGATGAAAGGA	0.423													7	66					0	0	1	0	0	T	87035618	C	T	87035618	3	4	48	1	0	0	0	0	1	0	0	0	43	893	31	1	379	1	ABCB4	7	87035618	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3211739	87035618	72103045	1905	6299										
ABCB4	5244	broad.mit.edu	37	chr7	87043015	87043015	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaactgtcctaatattttCtattgcctctgttgcaatct	4	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:87043015C>T	ENST00000265723.4	-	22	2812	c.2701G>A	c.(2701-2703)Gaa>Aaa	p.E901K	ABCB4_ENST00000453593.1_Missense_Mutation_p.E901K|ABCB4_ENST00000358400.3_Missense_Mutation_p.E901K|ABCB4_ENST00000359206.3_Missense_Mutation_p.E901K|ABCB4_ENST00000545634.1_Missense_Mutation_p.E901K	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	901	ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity	p.E901K(1)		breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTAATATTTTCTATTGCCTCT	0.343													20	39					0	0	1	0	0	T	87043015	C	T	87043015	3	4	48	1	0	0	0	0	1	0	0	0	43	922	32	3	1187	3	ABCB4	7	87043015	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7397	87043015	72095648	1906	6300										
ABCB1	5243	broad.mit.edu	37	chr7	87168615	87168615	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatcggaaaaccatgtatCggagccgcttggtgaggatc	14	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:87168615C>T	ENST00000265724.3	-	20	2783	c.2366G>A	c.(2365-2367)cGa>cAa	p.R789Q	ABCB1_ENST00000543898.1_Missense_Mutation_p.R725Q	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	789	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AACCATGTATCGGAGCCGCTT	0.522													14	26					0	0	1	0	0	T	87168615	C	T	87168615	3	4	48	1	0	0	0	0	1	0	0	0	40	884	31	1	1516	1	ABCB1	7	87168615	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	125600	87168615	71970048	1907	6301										
ABCB1	5243	broad.mit.edu	37	chr7	87196193	87196193	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaaaaactgttttctaatTttgtgtatttgtcttccagc	6	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:87196193T>G	ENST00000265724.3	-	7	855	c.438A>C	c.(436-438)aaA>aaC	p.K146N	ABCB1_ENST00000543898.1_Intron	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	146	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTTTTCTAATTTTGTGTATTT	0.433													18	40					0	0	1	0	0	G	87196193	T	G	87196193	3	3	48	1	0	0	0	0	1	0	0	0	40	1838	64	4	3496	4	ABCB1	7	87196193	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	27578	87196193	71942470	1908	6302										
STEAP4	79689	broad.mit.edu	37	chr7	87913198	87913198	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgttaaatgcttttaccacGtgggctcctggcaccaaatg	10	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:87913198G>A	ENST00000380079.4	-	2	488	c.387C>T	c.(385-387)caC>caT	p.H129H	AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000595121.1_RNA|STEAP4_ENST00000301959.5_Silent_p.H129H|STEAP4_ENST00000414498.1_Silent_p.H129H|AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000447758.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	129					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					CTTTTACCACGTGGGCTCCTG	0.423													25	74					0	0	1	0	0	A	87913198	G	A	87913198	2	1	48	1	0	0	0	0	0	0	0	1	15335	1136	40	1		1	STEAP4	7	87913198	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	717005	87913198	71225465	1909	6303										
ZNF804B	219578	broad.mit.edu	37	chr7	88389380	88389380	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaggggacccctgtgcaaGaacggatctccctctccggt	11	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:88389380G>T	ENST00000333190.4	+	1	699	c.90G>T	c.(88-90)aaG>aaT	p.K30N		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	30						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCCTGTGCAAGAACGGATCTC	0.502										HNSCC(36;0.09)			32	80					9.65021e-13	1.22324e-12	1	1	0	T	88389380	G	T	88389380	3	4	48	1	0	0	0	0	1	0	0	0	18219	933	33	2	92	2	ZNF804B	7	88389380	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	476182	88389380	70749283	1910	6304										
ZNF804B	219578	broad.mit.edu	37	chr7	88962766	88962766	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccccattaagaatggcaGaaaggtatcatgcatgaaga	9	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:88962766G>T	ENST00000333190.4	+	4	1079	c.470G>T	c.(469-471)aGa>aTa	p.R157I		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	157						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAGAATGGCAGAAAGGTATCA	0.438										HNSCC(36;0.09)			20	29					4.96729e-08	5.79844e-08	1	1	0	T	88962766	G	T	88962766	3	4	48	1	0	0	0	0	1	0	0	0	18219	942	33	2	484	2	ZNF804B	7	88962766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	573386	88962766	70175897	1911	6305										
ZNF804B	219578	broad.mit.edu	37	chr7	88964251	88964251	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttggaatttgaagatgaaaGacaattcaactgcaagtcca	8	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:88964251G>T	ENST00000333190.4	+	4	2564	c.1955G>T	c.(1954-1956)aGa>aTa	p.R652I		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	652						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GAAGATGAAAGACAATTCAAC	0.398										HNSCC(36;0.09)			24	38					2.44723e-14	3.18537e-14	1	1	0	T	88964251	G	T	88964251	3	4	48	1	0	0	0	0	1	0	0	0	18219	942	33	2	1969	2	ZNF804B	7	88964251	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1485	88964251	70174412	1912	6306										
ZNF804B	219578	broad.mit.edu	37	chr7	88964999	88964999	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatatcagctgccttctaaaGaactgttccagtggcccttc	7	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:88964999G>T	ENST00000333190.4	+	4	3312	c.2703G>T	c.(2701-2703)aaG>aaT	p.K901N		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	901						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GCCTTCTAAAGAACTGTTCCA	0.463										HNSCC(36;0.09)			36	104					3.62531e-18	4.89791e-18	1	1	0	T	88964999	G	T	88964999	3	4	48	1	0	0	0	0	1	0	0	0	18219	933	33	2	2717	2	ZNF804B	7	88964999	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	748	88964999	70173664	1913	6307										
C7orf63	79846	broad.mit.edu	37	chr7	89929205	89929205	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accaaaaaaaattctgtaatCtaatacttggaataatggtt	5	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:89929205C>A	ENST00000389297.4	+	17	2133	c.1882C>A	c.(1882-1884)Cta>Ata	p.L628I	C7orf63_ENST00000316089.8_Missense_Mutation_p.L628I|C7orf63_ENST00000497910.1_Missense_Mutation_p.L610I	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	628							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						ATTCTGTAATCTAATACTTGG	0.318													7	8					2.7689e-08	3.25926e-08	1	1	0	A	89929205	C	A	89929205	3	1	48	1	0	0	0	0	1	0	0	0	2425	912	32	2	1948	2	C7orf63	7	89929205	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	964206	89929205	69209458	1914	6308										
C7orf63	79846	broad.mit.edu	37	chr7	89934069	89934069	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttattttagattttgaaaatTtacctggcctatctgctgaa	6	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:89934069T>G	ENST00000389297.4	+	19	2451	c.2200T>G	c.(2200-2202)Tta>Gta	p.L734V	C7orf63_ENST00000316089.8_Missense_Mutation_p.L688V|C7orf63_ENST00000497910.1_Missense_Mutation_p.L716V	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	734							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						TTTTGAAAATTTACCTGGCCT	0.264													14	19					0	0	1	0	0	G	89934069	T	G	89934069	3	3	48	1	0	0	0	0	1	0	0	0	2425	1838	64	4	2274	4	C7orf63	7	89934069	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4864	89934069	69204594	1915	6309										
AKAP9	10142	broad.mit.edu	37	chr7	91724364	91724364	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttaaagataagacagatgaAgtacatttgcttaatgacac	8	5	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:91724364A>G	ENST00000359028.2	+	40	9843	c.9618A>G	c.(9616-9618)gaA>gaG	p.E3206E	AKAP9_ENST00000358100.2_Silent_p.E3152E|AKAP9_ENST00000356239.3_Silent_p.E3202E			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3206					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGACAGATGAAGTACATTTGC	0.383			T	BRAF	papillary thyroid								18	33					0	0	1	0	0	G	91724364	A	G	91724364	2	3	48	1	0	0	0	0	0	0	0	1	456	69	3	4		4	AKAP9	7	91724364	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1790295	91724364	67414299	1916	6310										
CYP51A1	1595	broad.mit.edu	37	chr7	91755658	91755658	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacagctgtgctaccttttCattgagttgacttctgattt	7	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:91755658C>A	ENST00000003100.8	-	5	844	c.679G>T	c.(679-681)Gaa>Taa	p.E227*	LRRD1_ENST00000422722.1_5'UTR|CYP51A1_ENST00000450723.1_Nonsense_Mutation_p.E122*	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	221					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	GCTACCTTTTCATTGAGTTGA	0.428													6	13					3.59834e-05	3.93264e-05	1	1	0	A	91755658	C	A	91755658	4	1	48	1	0	0	0	0	0	1	0	0	4218	835	29	2	874	2	CYP51A1	7	91755658	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31294	91755658	67383005	1917	6311										
PEX1	5189	broad.mit.edu	37	chr7	92131270	92131270	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgatccacaagtactgtaaAatctctagccacaaacccgc	5	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:92131270A>C	ENST00000248633.4	-	14	2445	c.2350T>G	c.(2350-2352)Ttt>Gtt	p.F784V	PEX1_ENST00000438045.1_Missense_Mutation_p.F462V|PEX1_ENST00000541751.1_Intron|PEX1_ENST00000428214.1_Missense_Mutation_p.F727V	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	784					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			AGTACTGTAAAATCTCTAGCC	0.378													52	114					0	0	1	0	0	C	92131270	A	C	92131270	3	2	48	1	0	0	0	0	1	0	0	0	11782	14	1	4	1545	4	PEX1	7	92131270	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	375612	92131270	67007393	1918	6312										
CDK6	1021	broad.mit.edu	37	chr7	92462505	92462505	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcgccggtctgcacccgcaCgcgcttcaacgccacgaaac	9	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:92462505C>T	ENST00000265734.4	-	2	544	c.133G>A	c.(133-135)Gtg>Atg	p.V45M	CDK6_ENST00000424848.2_Missense_Mutation_p.V45M	NM_001259.6	NP_001250.1	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	45	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TGCACCCGCACGCGCTTCAAC	0.662			T	MLLT10	ALL								6	13					0	0	1	0	0	T	92462505	C	T	92462505	3	4	48	1	0	0	0	0	1	0	0	0	3170	536	19	1	875	1	CDK6	7	92462505	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	331235	92462505	66676158	1919	6313										
SAMD9L	219285	broad.mit.edu	37	chr7	92761694	92761694	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaacttctatttcacccaaGaaacaagctgtgttatacat	4	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:92761694G>T	ENST00000318238.4	-	5	4807	c.3591C>A	c.(3589-3591)ttC>ttA	p.F1197L	SAMD9L_ENST00000411955.1_Missense_Mutation_p.F1197L|SAMD9L_ENST00000437805.1_Missense_Mutation_p.F1197L	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1197										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTCACCCAAGAAACAAGCTG	0.378													42	68					1.15505e-17	1.55342e-17	1	1	0	T	92761694	G	T	92761694	3	4	48	1	0	0	0	0	1	0	0	0	13878	933	33	2	1167	2	SAMD9L	7	92761694	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	299189	92761694	66376969	1920	6314										
SAMD9L	219285	broad.mit.edu	37	chr7	92764273	92764273	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttacaaacagtgaaagatTttggttttgtttccatattt	6	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:92764273T>G	ENST00000318238.4	-	5	2228	c.1012A>C	c.(1012-1014)Aat>Cat	p.N338H	SAMD9L_ENST00000411955.1_Missense_Mutation_p.N338H|SAMD9L_ENST00000437805.1_Missense_Mutation_p.N338H	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	338										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGTGAAAGATTTTGGTTTTGT	0.323													15	88					0	0	1	0	0	G	92764273	T	G	92764273	3	3	48	1	0	0	0	0	1	0	0	0	13878	1841	64	4	3746	4	SAMD9L	7	92764273	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2579	92764273	66374390	1921	6315										
HEPACAM2	253012	broad.mit.edu	37	chr7	92838084	92838084	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaggtgttggggggatgaGaatcagcagaacaatcaaat	14	4	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:92838084G>T	ENST00000394468.2	-	4	898	c.821C>A	c.(820-822)tCt>tAt	p.S274Y	HEPACAM2_ENST00000341723.4_Missense_Mutation_p.S262Y|HEPACAM2_ENST00000440868.1_Missense_Mutation_p.S262Y|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.S297Y	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	274	Ig-like C2-type 2.					integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						GGGGGGATGAGAATCAGCAGA	0.438													6	68					3.59834e-05	3.93264e-05	1	1	0	T	92838084	G	T	92838084	3	4	48	1	0	0	0	0	1	0	0	0	7093	942	33	2	595	2	HEPACAM2	7	92838084	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	73811	92838084	66300579	1922	6316										
CCDC132	55610	broad.mit.edu	37	chr7	92926544	92926544	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagtgtcaattatttcaaGaattaccataggtaagaact	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:92926544G>T	ENST00000544910.1	+	17	1480	c.1260G>T	c.(1258-1260)aaG>aaT	p.K420N	CCDC132_ENST00000305866.5_Missense_Mutation_p.K450N|CCDC132_ENST00000317751.6_Missense_Mutation_p.K181N|CCDC132_ENST00000541136.1_Missense_Mutation_p.K261N|CCDC132_ENST00000535481.1_Missense_Mutation_p.K170N	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	450								p.K450N(1)		endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTATTTCAAGAATTACCATA	0.284													5	23					0.0215528	0.0219788	1	1	0	T	92926544	G	T	92926544	3	4	48	1	0	0	0	0	1	0	0	0	2785	933	33	2	1454	2	CCDC132	7	92926544	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	88460	92926544	66212119	1923	6317										
COL1A2	1278	broad.mit.edu	37	chr7	94052341	94052341	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggtcctcgtggtgaccaaGgtccagttggccgaactgga	15	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:94052341G>T	ENST00000297268.6	+	40	2947	c.2476G>T	c.(2476-2478)Ggt>Tgt	p.G826C		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	826			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTGACCAAGGTCCAGTTGG	0.562										HNSCC(75;0.22)			44	71					1.15505e-17	1.55342e-17	1	1	0	T	94052341	G	T	94052341	3	4	48	1	0	0	0	0	1	0	0	0	3701	1000	35	5	2634	5	COL1A2	7	94052341	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1125797	94052341	65086322	1924	6318										
CASD1	64921	broad.mit.edu	37	chr7	94163031	94163031	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtagcagtgaagcgctttCtcaatataaaatgaacatca	8	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:94163031C>T	ENST00000297273.4	+	7	832	c.545C>T	c.(544-546)tCt>tTt	p.S182F		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	182						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GAAGCGCTTTCTCAATATAAA	0.318													6	33					0	0	1	0	0	T	94163031	C	T	94163031	3	4	48	1	0	0	0	0	1	0	0	0	2682	913	32	3	571	3	CASD1	7	94163031	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	110690	94163031	64975632	1925	6319										
CASD1	64921	broad.mit.edu	37	chr7	94178860	94178860	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagggtgcatttgagaagAtcttttctctttggccattg	10	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:94178860A>C	ENST00000297273.4	+	14	2016	c.1729A>C	c.(1729-1731)Atc>Ctc	p.I577L		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	577						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ATTTGAGAAGATCTTTTCTCT	0.333													18	34					0	0	1	0	0	C	94178860	A	C	94178860	3	2	48	1	0	0	0	0	1	0	0	0	2682	333	12	4	1783	4	CASD1	7	94178860	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	15829	94178860	64959803	1926	6320										
PEG10	23089	broad.mit.edu	37	chr7	94292899	94292899	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaagggacgagctctctGaagagatcaacaacttaaga	11	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:94292899G>A	ENST00000482108.1	+	2	510	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	PEG10_ENST00000488574.1_Missense_Mutation_p.E11K	NM_001040152.1|NM_001172438.1|NM_001184962.1	NP_001035242.1|NP_001165909.1|NP_001171891.1	Q86TG7	PEG10_HUMAN	paternally expressed 10	11					apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(9)|prostate(3)|skin(1)	21	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CGAGCTCTCTGAAGAGATCAA	0.527													12	7					0	0	1	0	0	A	94292899	G	A	94292899	3	1	48	1	0	0	0	0	1	0	0	0	11765	1294	45	3	265	3	PEG10	7	94292899	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	114039	94292899	64845764	1927	6321										
SLC25A13	10165	broad.mit.edu	37	chr7	95813664	95813664	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgtttttatacatgagttCtcccacaaaagagccagttg	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:95813664C>A	ENST00000416240.2	-	11	1295	c.1105G>T	c.(1105-1107)Gaa>Taa	p.E369*	SLC25A13_ENST00000542654.1_Nonsense_Mutation_p.E260*|SLC25A13_ENST00000265631.5_Nonsense_Mutation_p.E368*	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	368					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity	p.E368*(1)		breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TACATGAGTTCTCCCACAAAA	0.398													6	52					0.0215528	0.0219788	1	1	0	A	95813664	C	A	95813664	4	1	48	1	0	0	0	0	0	1	0	0	14529	922	32	2	957	2	SLC25A13	7	95813664	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1520765	95813664	63324999	1928	6322										
SLC25A13	10165	broad.mit.edu	37	chr7	95813703	95813703	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatcgttggttctgcattcGagtttttacaagatcgatag	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:95813703G>A	ENST00000416240.2	-	11	1256	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	SLC25A13_ENST00000542654.1_Nonsense_Mutation_p.R247*|SLC25A13_ENST00000265631.5_Nonsense_Mutation_p.R355*	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	355					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TTCTGCATTCGAGTTTTTACA	0.373													19	25					0	0	1	0	0	A	95813703	G	A	95813703	4	1	48	1	0	0	0	0	0	1	0	0	14529	1066	37	1	996	1	SLC25A13	7	95813703	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	39	95813703	63324960	1929	6323										
DLX5	1749	broad.mit.edu	37	chr7	96650352	96650352	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatcttcttgatcttggatCttttgttctgaaaccagatt	7	7	5	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:96650352C>A	ENST00000222598.4	-	3	1039	c.566G>T	c.(565-567)aGa>aTa	p.R189I	DLX5_ENST00000493764.1_5'UTR	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	189					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GATCTTGGATCTTTTGTTCTG	0.587													11	26					1.61879e-10	1.99092e-10	1	1	0	A	96650352	C	A	96650352	3	1	48	1	0	0	0	0	1	0	0	0	4602	913	32	2	307	2	DLX5	7	96650352	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	836649	96650352	62488311	1930	6324										
LMTK2	22853	broad.mit.edu	37	chr7	97788728	97788728	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctcctggtgtttgagttCtgtgacttggtaagttcctt	10	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:97788728C>A	ENST00000297293.5	+	6	941	c.648C>A	c.(646-648)ttC>ttA	p.F216L		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	216	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TGTTTGAGTTCTGTGACTTGG	0.423													14	40					2.61681e-11	3.25035e-11	1	1	0	A	97788728	C	A	97788728	3	1	48	1	0	0	0	0	1	0	0	0	8899	912	32	2	670	2	LMTK2	7	97788728	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1138376	97788728	61349935	1931	6325										
NPTX2	4885	broad.mit.edu	37	chr7	98257875	98257875	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgtgggtggacaataacgtCgatgtgttcggaggggcctc	16	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:98257875C>T	ENST00000265634.3	+	5	1395	c.1230C>T	c.(1228-1230)gtC>gtT	p.V410V		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	410	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding	p.V410V(1)		breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			ACAATAACGTCGATGTGTTCG	0.582													4	10					0	0	1	0	0	T	98257875	C	T	98257875	2	4	48	1	0	0	0	0	0	0	0	1	10650	871	31	1		1	NPTX2	7	98257875	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	469147	98257875	60880788	1932	6326										
TRRAP	8295	broad.mit.edu	37	chr7	98515126	98515126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgtctcaccgtccctgtgCggctgagctcgcttttgccg	12	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:98515126C>T	ENST00000359863.4	+	20	2655	c.2446C>T	c.(2446-2448)Cgg>Tgg	p.R816W	TRRAP_ENST00000446306.3_Missense_Mutation_p.R815W|TRRAP_ENST00000355540.3_Missense_Mutation_p.R816W	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	816					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.R816W(2)		NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGTCCCTGTGCGGCTGAGCTC	0.577													18	46					0	0	1	0	0	T	98515126	C	T	98515126	3	4	48	1	0	0	0	0	1	0	0	0	16661	759	27	1	2520	1	TRRAP	7	98515126	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	257251	98515126	60623537	1933	6327										
TRRAP	8295	broad.mit.edu	37	chr7	98519436	98519436	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccacgtggcctaccgtgtgCtcggtaagtttggcggcagt	14	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:98519436C>T	ENST00000359863.4	+	21	2892	c.2683C>T	c.(2683-2685)Ctc>Ttc	p.L895F	TRRAP_ENST00000446306.3_Missense_Mutation_p.L894F|TRRAP_ENST00000355540.3_Missense_Mutation_p.L895F	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	895					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTACCGTGTGCTCGGTAAGTT	0.547													53	90					0	0	1	0	0	T	98519436	C	T	98519436	3	4	48	1	0	0	0	0	1	0	0	0	16661	797	28	3	2761	3	TRRAP	7	98519436	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4310	98519436	60619227	1934	6328										
TRRAP	8295	broad.mit.edu	37	chr7	98530911	98530911	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcacctgctccgacaccaGcctgccaacgcacagattgg	9	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:98530911G>A	ENST00000359863.4	+	27	4109	c.3900G>A	c.(3898-3900)caG>caA	p.Q1300Q	TRRAP_ENST00000446306.3_Silent_p.Q1299Q|TRRAP_ENST00000355540.3_Silent_p.Q1300Q	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1300					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCGACACCAGCCTGCCAACG	0.582													9	23					0	0	1	0	0	A	98530911	G	A	98530911	2	1	48	1	0	0	0	0	0	0	0	1	16661	962	34	3		3	TRRAP	7	98530911	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11475	98530911	60607752	1935	6329										
TRRAP	8295	broad.mit.edu	37	chr7	98609882	98609882	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcacaacctcgcccagttCgaaggcggggaaagcaaggt	13	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:98609882C>T	ENST00000359863.4	+	72	11693	c.11484C>T	c.(11482-11484)ttC>ttT	p.F3828F	TRRAP_ENST00000446306.3_Silent_p.F3817F|TRRAP_ENST00000355540.3_Silent_p.F3799F	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3828	FATC.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.F3799F(1)|p.F3828F(1)		NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCGCCCAGTTCGAAGGCGGGG	0.642													14	14					0	0	1	0	0	T	98609882	C	T	98609882	2	4	48	1	0	0	0	0	0	0	0	1	16661	883	31	1		1	TRRAP	7	98609882	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	78971	98609882	60528781	1936	6330										
BUD31	8896	broad.mit.edu	37	chr7	99013774	99013774	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccccagctgaaacagaaccGcatgagggaaagaggaaagt	12	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:99013774G>A	ENST00000403633.2	+	4	637	c.108G>A	c.(106-108)ccG>ccA	p.P36P	BUD31_ENST00000456893.1_Intron|BUD31_ENST00000431419.1_Silent_p.P7P|BUD31_ENST00000222969.5_Silent_p.P36P			P41223	BUD31_HUMAN	BUD31 homolog (S. cerevisiae)	36					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity	p.P36P(1)		autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)	4	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AAACAGAACCGCATGAGGGAA	0.463													5	69					0	0	1	0	0	A	99013774	G	A	99013774	2	1	48	1	0	0	0	0	0	0	0	1	1577	1074	38	1		1	BUD31	7	99013774	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	403892	99013774	60124889	1937	6331										
ZNF655	79027	broad.mit.edu	37	chr7	99169914	99169914	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttgattcctaagcagaaAatttcggaagaagtgcattc	9	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:99169914A>G	ENST00000424881.1	+	4	508	c.288A>G	c.(286-288)aaA>aaG	p.K96K	ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000252713.4_Silent_p.K61K|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000394163.2_Silent_p.K61K|ZNF655_ENST00000493277.1_Silent_p.K96K	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	61					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CTAAGCAGAAAATTTCGGAAG	0.383													18	48					0	0	1	0	0	G	99169914	A	G	99169914	2	3	48	1	0	0	0	0	0	0	0	1	18124	11	1	4		4	ZNF655	7	99169914	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	156140	99169914	59968749	1938	6332										
CYP3A43	64816	broad.mit.edu	37	chr7	99454470	99454470	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccagcatcgagtagatttCtttcaacagatgatcgactc	7	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:99454470C>A	ENST00000354829.2	+	9	916	c.813C>A	c.(811-813)ttC>ttA	p.F271L	CYP3A43_ENST00000222382.5_Missense_Mutation_p.F271L|CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000312017.5_Missense_Mutation_p.F271L|CYP3A43_ENST00000417625.1_Missense_Mutation_p.F161L|CYP3A43_ENST00000444905.1_Missense_Mutation_p.F18L|CYP3A43_ENST00000342499.4_Missense_Mutation_p.F131L|CYP3A43_ENST00000415413.1_Missense_Mutation_p.F60L	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	271			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	GAGTAGATTTCTTTCAACAGA	0.443													29	60					6.07407e-21	8.36301e-21	1	1	0	A	99454470	C	A	99454470	3	1	48	1	0	0	0	0	1	0	0	0	4202	912	32	2	847	2	CYP3A43	7	99454470	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	284556	99454470	59684193	1939	6333										
AZGP1	563	broad.mit.edu	37	chr7	99564860	99564860	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggccaggcacttcagtttCttcttttctcctggggcctg	10	12	4	0	rs71696698		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:99564860C>A	ENST00000292401.4	-	4	799	c.663G>T	c.(661-663)aaG>aaT	p.K221N	AZGP1_ENST00000483612.1_5'UTR|AZGP1_ENST00000411734.1_3'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	221	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					ACTTCAGTTTCTTCTTTTCTC	0.582													8	20					5.4927e-09	6.54492e-09	1	1	0	A	99564860	C	A	99564860	3	1	48	1	0	0	0	0	1	0	0	0	1237	912	32	2	237	2	AZGP1	7	99564860	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	110390	99564860	59573803	1940	6334										
STAG3	10734	broad.mit.edu	37	chr7	99798886	99798886	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcccctttctcccccaaaGcactcatgacctgactcgct	4	18	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:99798886G>A	ENST00000426455.1	+	21	2539		c.e21-1		GATS_ENST00000436886.2_3'UTR|GATS_ENST00000543273.1_RNA|STAG3_ENST00000317296.5_Splice_Site|STAG3_ENST00000440830.1_Splice_Site|STAG3_ENST00000394018.2_Splice_Site			Q9UJ98	STAG3_HUMAN	stromal antigen 3						chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCCCCCAAAGCACTCATGAC	0.532													28	78					0	0	1	0	0	A	99798886	G	A	99798886	5	1	48	1	0	0	0	0	0	0	1	0	15299	985	34	3	2210	3	STAG3	7	99798886	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	234026	99798886	59339777	1941	6335										
PCOLCE	5118	broad.mit.edu	37	chr7	100203323	100203323	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgcgctgaccttcgagaagTttgacctggagccggacacc	12	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100203323T>C	ENST00000223061.5	+	5	893	c.613T>C	c.(613-615)Ttt>Ctt	p.F205L		NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	205	CUB 2.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTTCGAGAAGTTTGACCTGGA	0.677													7	7					0	0	1	0	0	C	100203323	T	C	100203323	3	2	48	1	0	0	0	0	1	0	0	0	11640	1725	60	4	631	4	PCOLCE	7	100203323	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	404437	100203323	58935340	1942	6336										
ZAN	7455	broad.mit.edu	37	chr7	100349380	100349380	+	RNA	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtatctccagtttcttccaCtggcccttctgaaaccactg	6	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100349380C>A	ENST00000542585.1	+	0	1800				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTTTCTTCCACTGGCCCTTCT	0.463													6	48					2.0095e-06	2.25447e-06	1	1	0	A	100349380	C	A	100349380	1	1	48	0	1	0	0	0	0	0	0	0	17572	565	20	5		5	ZAN	7	100349380	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	146057	100349380	58789283	1943	6337										
ZAN	7455	broad.mit.edu	37	chr7	100350691	100350691	+	RNA	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaacccaccatccccacagAaaaacccaccattcccacag	2	19	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100350691A>C	ENST00000542585.1	+	0	3111				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ATCCCCACAGAAAAACCCACC	0.572													80	134					0	0	1	0	0	C	100350691	A	C	100350691	1	2	48	0	1	0	0	0	0	0	0	0	17572	246	9	4		4	ZAN	7	100350691	RNA	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1311	100350691	58787972	1944	6338										
ZAN	7455	broad.mit.edu	37	chr7	100363120	100363120	+	RNA	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttcgtcctcagtggcctCgagtgcatacctcgctccca	10	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100363120C>T	ENST00000542585.1	+	0	4561				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCAGTGGCCTCGAGTGCATAC	0.617													10	13					0	0	1	0	0	T	100363120	C	T	100363120	1	4	48	0	1	0	0	0	0	0	0	0	17572	871	31	1		1	ZAN	7	100363120	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12429	100363120	58775543	1945	6339										
ZAN	7455	broad.mit.edu	37	chr7	100366245	100366245	+	RNA	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctctagggaactacaacaAcaacagcttggatgacaacc	7	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100366245A>G	ENST00000542585.1	+	0	5202				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AACTACAACAACAACAGCTTG	0.592													8	14					0	0	1	0	0	G	100366245	A	G	100366245	1	3	48	0	1	0	0	0	0	0	0	0	17572	43	2	4		4	ZAN	7	100366245	RNA	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3125	100366245	58772418	1946	6340										
EPHB4	2050	broad.mit.edu	37	chr7	100401201	100401201	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgccagagtgactccgattCggagcaggtccctgcagaag	13	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100401201C>T	ENST00000358173.3	-	17	3314	c.2846G>A	c.(2845-2847)cGa>cAa	p.R949Q	EPHB4_ENST00000360620.3_Missense_Mutation_p.R897Q	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	949	SAM.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					GACTCCGATTCGGAGCAGGTC	0.607													4	17					0	0	1	0	0	T	100401201	C	T	100401201	3	4	48	1	0	0	0	0	1	0	0	0	5205	884	31	1	121	1	EPHB4	7	100401201	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34956	100401201	58737462	1947	6341										
MUC17	140453	broad.mit.edu	37	chr7	100674925	100674925	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtacaacatctacaaatgtCgtggagccaagaatgtattt	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100674925C>T	ENST00000306151.4	+	3	292	c.228C>T	c.(226-228)gtC>gtT	p.V76V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	76						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTACAAATGTCGTGGAGCCAA	0.453													37	54					0	0	1	0	0	T	100674925	C	T	100674925	2	4	48	1	0	0	0	0	0	0	0	1	10021	871	31	1		1	MUC17	7	100674925	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	273724	100674925	58463738	1948	6342										
MUC17	140453	broad.mit.edu	37	chr7	100685698	100685698	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaccagcacacctgtgatCacttctacccaagtcagttc	6	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100685698C>A	ENST00000306151.4	+	3	11065	c.11001C>A	c.(10999-11001)atC>atA	p.I3667I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3667	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTGTGATCACTTCTACCC	0.502													84	150					1.59627e-33	2.29092e-33	1	1	0	A	100685698	C	A	100685698	2	1	48	1	0	0	0	0	0	0	0	1	10021	816	29	2		2	MUC17	7	100685698	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10773	100685698	58452965	1949	6343										
MUC17	140453	broad.mit.edu	37	chr7	100695217	100695217	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaacctcggcaagtgccaGatgtctctaagtggacctca	10	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:100695217G>T	ENST00000306151.4	+	9	13141	c.13077G>T	c.(13075-13077)caG>caT	p.Q4359H		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4359						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCAAGTGCCAGATGTCTCTAA	0.597													65	115					3.57465e-26	5.05666e-26	1	1	0	T	100695217	G	T	100695217	3	4	48	1	0	0	0	0	1	0	0	0	10021	933	33	2	13111	2	MUC17	7	100695217	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9519	100695217	58443446	1950	6344										
ORAI2	80228	broad.mit.edu	37	chr7	102087367	102087367	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcccgtgggcctcatcttCgtggtcttcaccatccactt	9	15	4	0	rs144660402		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:102087367C>T	ENST00000356387.2	+	4	868	c.633C>T	c.(631-633)ttC>ttT	p.F211F	ORAI2_ENST00000473939.1_Silent_p.F211F|ORAI2_ENST00000403646.3_Silent_p.F211F|ORAI2_ENST00000488996.1_3'UTR|ORAI2_ENST00000478730.1_Silent_p.F211F	NM_001126340.1|NM_001271818.1|NM_001271819.1|NM_032831.3	NP_001119812.1|NP_001258747.1|NP_001258748.1|NP_116220.1	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator 2	211						integral to membrane	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15						GCCTCATCTTCGTGGTCTTCA	0.667													14	37					0	0	1	0	0	T	102087367	C	T	102087367	2	4	48	1	0	0	0	0	0	0	0	1	11304	883	31	1		1	ORAI2	7	102087367	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1392150	102087367	57051296	1951	6345										
SRPK2	6733	broad.mit.edu	37	chr7	104801000	104801000	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtactgggaggccttgatagTtggatttgatgatccacttg	13	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:104801000T>G	ENST00000357311.3	-	6	713	c.542A>C	c.(541-543)aAc>aCc	p.N181T	SRPK2_ENST00000393651.3_Missense_Mutation_p.N192T|SRPK2_ENST00000489828.1_Missense_Mutation_p.N181T	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	181	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						GCCTTGATAGTTGGATTTGAT	0.493													23	34					0	0	1	0	0	G	104801000	T	G	104801000	3	3	48	1	0	0	0	0	1	0	0	0	15215	1725	60	4	1564	4	SRPK2	7	104801000	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2713633	104801000	54337663	1952	6346										
CDHR3	222256	broad.mit.edu	37	chr7	105672986	105672986	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagggatggggtcactgaGaagtgccaactgggaagaag	18	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:105672986G>A	ENST00000542731.1	+	19	2609	c.2501G>A	c.(2500-2502)aGa>aAa	p.R834K	CDHR3_ENST00000478080.1_Missense_Mutation_p.R746K|CDHR3_ENST00000317716.9_Missense_Mutation_p.R834K|CDHR3_ENST00000343407.5_3'UTR			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	834					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						GGGTCACTGAGAAGTGCCAAC	0.562													24	46					0	0	1	0	0	A	105672986	G	A	105672986	3	1	48	1	0	0	0	0	1	0	0	0	3142	942	33	3	2575	3	CDHR3	7	105672986	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	871986	105672986	53465677	1953	6347										
SLC26A4	5172	broad.mit.edu	37	chr7	107323664	107323664	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagacgctggttgagattttTcaaaatattggtgataccaa	9	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:107323664T>G	ENST00000265715.3	+	7	1007	c.783T>G	c.(781-783)ttT>ttG	p.F261L		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	261					regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						TTGAGATTTTTCAAAATATTG	0.388									Pendred syndrome				15	26					0	0	1	0	0	G	107323664	T	G	107323664	3	3	48	1	0	0	0	0	1	0	0	0	14573	1780	62	4	805	4	SLC26A4	7	107323664	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1650678	107323664	51814999	1954	6348										
LAMB1	3912	broad.mit.edu	37	chr7	107635333	107635333	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagtcatggatttcttaccTtgaaagtcattatgagatga	8	5	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:107635333T>G	ENST00000393561.1	-	3	678	c.495_splice	c.e3+1	p.K165_splice	LAMB1_ENST00000222399.6_Splice_Site_p.K141_splice|LAMB1_ENST00000393560.1_Splice_Site_p.K141_splice			P07942	LAMB1_HUMAN	laminin, beta 1	141	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTTCTTACCTTGAAAGTCAT	0.358													5	9					0	0	1	0	0	G	107635333	T	G	107635333	5	3	48	1	0	0	0	0	0	0	1	0	8648	1623	56	4	5058	4	LAMB1	7	107635333	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	311669	107635333	51503330	1955	6349										
NRCAM	4897	broad.mit.edu	37	chr7	107832197	107832197	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacgctaagcacagcgctggCggagacgctgtccagagtgg	15	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:107832197C>T	ENST00000379028.3	-	18	2349	c.1879G>A	c.(1879-1881)Gcc>Acc	p.A627T	NRCAM_ENST00000379022.4_Missense_Mutation_p.A627T|NRCAM_ENST00000351718.4_Missense_Mutation_p.A621T|NRCAM_ENST00000379024.4_Missense_Mutation_p.A608T|NRCAM_ENST00000425651.2_Missense_Mutation_p.A627T|NRCAM_ENST00000413765.2_Missense_Mutation_p.A608T			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	627	Ig-like 6.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						ACAGCGCTGGCGGAGACGCTG	0.453													12	31					0	0	1	0	0	T	107832197	C	T	107832197	3	4	48	1	0	0	0	0	1	0	0	0	10691	768	27	1	2129	1	NRCAM	7	107832197	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	196864	107832197	51306466	1956	6350										
DNAJB9	4189	broad.mit.edu	37	chr7	108212299	108212299	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatcagagcgccaaatcaaGaaggcctttcacaagttggc	10	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:108212299G>T	ENST00000249356.3	+	2	675	c.129G>T	c.(127-129)aaG>aaT	p.K43N	DNAJB9_ENST00000465725.1_3'UTR	NM_012328.2	NP_036460.1	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	43	J.				ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13						GCCAAATCAAGAAGGCCTTTC	0.398													46	87					8.86878e-18	1.19361e-17	1	1	0	T	108212299	G	T	108212299	3	4	48	1	0	0	0	0	1	0	0	0	4654	933	33	2	131	2	DNAJB9	7	108212299	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	380102	108212299	50926364	1957	6351										
DOCK4	9732	broad.mit.edu	37	chr7	111418353	111418353	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaaagttctgtgctttgaGatgcagatcatagagtttgt	11	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:111418353G>T	ENST00000428084.1	-	36	3930	c.3658C>A	c.(3658-3660)Ctc>Atc	p.L1220I	DOCK4_ENST00000437633.1_Missense_Mutation_p.L1211I|DOCK4_ENST00000494651.2_Missense_Mutation_p.L94I			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1211	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TGTGCTTTGAGATGCAGATCA	0.368													21	41					7.87624e-14	1.01695e-13	1	1	0	T	111418353	G	T	111418353	3	4	48	1	0	0	0	0	1	0	0	0	4716	942	33	2	2341	2	DOCK4	7	111418353	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3206054	111418353	47720310	1958	6352										
DOCK4	9732	broad.mit.edu	37	chr7	111541793	111541793	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttccacatttctggccacGctcttccctcctttctcaaa	3	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:111541793G>A	ENST00000428084.1	-	14	1529	c.1257C>T	c.(1255-1257)agC>agT	p.S419S	DOCK4_ENST00000437633.1_Silent_p.S419S|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	419	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TTCTGGCCACGCTCTTCCCTC	0.363													8	25					0	0	1	0	0	A	111541793	G	A	111541793	2	1	48	1	0	0	0	0	0	0	0	1	4716	1078	38	1		1	DOCK4	7	111541793	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	123440	111541793	47596870	1959	6353										
DOCK4	9732	broad.mit.edu	37	chr7	111584871	111584871	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtgttatacctaccgattCggataatgtgcacggtgata	10	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:111584871C>T	ENST00000428084.1	-	10	1111	c.839G>A	c.(838-840)cGa>cAa	p.R280Q	DOCK4_ENST00000437633.1_Missense_Mutation_p.R280Q|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	280					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CCTACCGATTCGGATAATGTG	0.418													6	24					0	0	1	0	0	T	111584871	C	T	111584871	3	4	48	1	0	0	0	0	1	0	0	0	4716	884	31	1	5233	1	DOCK4	7	111584871	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	43078	111584871	47553792	1960	6354										
ZNF277	11179	broad.mit.edu	37	chr7	111976201	111976201	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagttcagttggaagatgatCgggagttgctggaccatcag	14	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:111976201C>T	ENST00000361822.3	+	8	973	c.844C>T	c.(844-846)Cgg>Tgg	p.R282W	AC004112.4_ENST00000431064.1_RNA	NM_021994.2	NP_068834.2	Q9NRM2	ZN277_HUMAN	zinc finger protein 277	282						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	15						GGAAGATGATCGGGAGTTGCT	0.413													13	39					0	0	1	0	0	T	111976201	C	T	111976201	3	4	48	1	0	0	0	0	1	0	0	0	17869	875	31	1	874	1	ZNF277	7	111976201	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	391330	111976201	47162462	1961	6355										
C7orf60	154743	broad.mit.edu	37	chr7	112461939	112461939	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatcttctatatctgatcGaacatagcaggaagggttag	9	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:112461939G>A	ENST00000297145.4	-	5	1243	c.1078C>T	c.(1078-1080)Cga>Tga	p.R360*		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	360										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						atatctGATCGAACATAGCAG	0.398													9	32					0	0	1	0	0	A	112461939	G	A	112461939	4	1	48	1	0	0	0	0	0	1	0	0	2423	1066	37	1	143	1	C7orf60	7	112461939	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	485738	112461939	46676724	1962	6356										
GPR85	0	broad.mit.edu	37	chr7	112724250	112724250	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattagccctgaaggagcggTgttggaaggtgcattgatct	14	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:112724250T>C	ENST00000501255.2	-	3	1150	c.527A>G	c.(526-528)cAc>cGc	p.H176R	GPR85_ENST00000424100.1_Missense_Mutation_p.H176R|GPR85_ENST00000297146.2_Missense_Mutation_p.H176R|GPR85_ENST00000449591.1_Missense_Mutation_p.H176R	NM_001146265.1|NM_001146266.1|NM_018970.6	NP_001139737.1|NP_001139738.1|NP_061843.3	P60893	GPR85_HUMAN	G protein-coupled receptor 85	176						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						GAAGGAGCGGTGTTGGAAGGT	0.483													20	52					0	0	1	0	0	C	112724250	T	C	112724250	3	2	48	1	0	0	0	0	1	0	0	0	6754	1696	59	4	589	4	GPR85	7	112724250	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	262311	112724250	46414413	1963	6357										
PPP1R3A	5506	broad.mit.edu	37	chr7	113519003	113519003	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatgccatgatcagctagaGaagacagttcacagcacact	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:113519003G>T	ENST00000284601.3	-	4	2212	c.2144C>A	c.(2143-2145)tCt>tAt	p.S715Y		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	715					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ATCAGCTAGAGAAGACAGTTC	0.408													37	84					1.21669e-08	1.44061e-08	1	1	0	T	113519003	G	T	113519003	3	4	48	1	0	0	0	0	1	0	0	0	12419	942	33	2	1228	2	PPP1R3A	7	113519003	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	794753	113519003	45619660	1964	6358										
PPP1R3A	5506	broad.mit.edu	37	chr7	113519436	113519436	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattgcccgggtggggattgCggtatgttcgctcagcagag	17	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:113519436C>T	ENST00000284601.3	-	4	1779	c.1711G>A	c.(1711-1713)Gca>Aca	p.A571T		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	571					glycogen metabolic process	integral to membrane		p.A571T(1)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GTGGGGATTGCGGTATGTTCG	0.473													37	50					0	0	1	0	0	T	113519436	C	T	113519436	3	4	48	1	0	0	0	0	1	0	0	0	12419	768	27	1	1661	1	PPP1R3A	7	113519436	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	433	113519436	45619227	1965	6359										
FOXP2	93986	broad.mit.edu	37	chr7	114282503	114282503	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agattcagcagttatggaaaGaagtgactggagttcacagt	12	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:114282503G>T	ENST00000393500.3	+	13	1409	c.589G>T	c.(589-591)Gaa>Taa	p.E197*	FOXP2_ENST00000393491.3_Nonsense_Mutation_p.E180*|FOXP2_ENST00000350908.4_Nonsense_Mutation_p.E272*|FOXP2_ENST00000360232.4_Nonsense_Mutation_p.E272*|FOXP2_ENST00000393494.2_Nonsense_Mutation_p.E272*|FOXP2_ENST00000403559.4_Nonsense_Mutation_p.E289*|FOXP2_ENST00000390668.3_Nonsense_Mutation_p.E296*|FOXP2_ENST00000378237.3_Nonsense_Mutation_p.E272*|FOXP2_ENST00000393489.3_Nonsense_Mutation_p.E180*|FOXP2_ENST00000408937.3_Nonsense_Mutation_p.E297*|FOXP2_ENST00000393498.2_Nonsense_Mutation_p.E251*			O15409	FOXP2_HUMAN	forkhead box P2	272	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GTTATGGAAAGAAGTGACTGG	0.408													23	32					8.04996e-18	1.08523e-17	1	1	0	T	114282503	G	T	114282503	4	4	48	1	0	0	0	0	0	1	0	0	6060	943	33	2	970	2	FOXP2	7	114282503	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	763067	114282503	44856160	1966	6360										
CAV2	858	broad.mit.edu	37	chr7	116140470	116140470	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggccttcattgcgggaattCtctttgccaccctcagctgt	9	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:116140470C>A	ENST00000222693.4	+	2	699	c.307C>A	c.(307-309)Ctc>Atc	p.L103I	CAV2_ENST00000393480.2_Missense_Mutation_p.L103I|CAV2_ENST00000343213.2_Intron|CAV2_ENST00000462876.1_3'UTR	NM_001206747.1|NM_001206748.1|NM_001233.4	NP_001193676.1|NP_001193677.1|NP_001224.1	P51636	CAV2_HUMAN	caveolin 2	103					caveola assembly|endoplasmic reticulum organization|mitochondrion organization|negative regulation of endothelial cell proliferation|positive regulation of dopamine receptor signaling pathway|regulation of mitosis|skeletal muscle fiber development|vesicle docking|vesicle fusion	caveola|extrinsic to internal side of plasma membrane|Golgi membrane|integral to plasma membrane|membrane fraction|nucleus|perinuclear region of cytoplasm|transport vesicle	D1 dopamine receptor binding|protein homodimerization activity	p.L103F(1)		large_intestine(1)|lung(1)|skin(1)	3	all_epithelial(6;1.53e-06)|Lung NSC(10;0.00592)|all_lung(10;0.00642)		STAD - Stomach adenocarcinoma(10;0.00878)			TGCGGGAATTCTCTTTGCCAC	0.552													26	62					7.76418e-22	1.07612e-21	1	1	0	A	116140470	C	A	116140470	3	1	48	1	0	0	0	0	1	0	0	0	2712	913	32	2	313	2	CAV2	7	116140470	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1857967	116140470	42998193	1967	6361										
MET	0	broad.mit.edu	37	chr7	116371750	116371750	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaaattcatcaggctgtgAagcgcgccgtgatgaatatc	12	8	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:116371750A>G	ENST00000397752.3	+	3	1429	c.1229A>G	c.(1228-1230)gAa>gGa	p.E410G	MET_ENST00000318493.6_Missense_Mutation_p.E410G|MET_ENST00000495962.1_3'UTR|MET_ENST00000436117.2_Missense_Mutation_p.E410G	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	410	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TCAGGCTGTGAAGCGCGCCGT	0.418			Mis		"papillary renal, head-neck squamous cell "	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				16	27					0	0	1	0	0	G	116371750	A	G	116371750	3	3	48	1	0	0	0	0	1	0	0	0	9534	246	9	4	1235	4	MET	7	116371750	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	231280	116371750	42766913	1968	6362										
ASZ1	136991	broad.mit.edu	37	chr7	117024855	117024855	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtagcattttattagctccAagttcaagcaacttcaaaac	5	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:117024855A>G	ENST00000284629.2	-	6	674	c.612T>C	c.(610-612)ctT>ctC	p.L204L		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	204					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TATTAGCTCCAAGTTCAAGCA	0.368													22	46					0	0	1	0	0	G	117024855	A	G	117024855	2	3	48	1	0	0	0	0	0	0	0	1	1068	117	5	4		4	ASZ1	7	117024855	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	653105	117024855	42113808	1969	6363										
CFTR	1080	broad.mit.edu	37	chr7	117230480	117230480	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagatgttttaacagaaaaaGaaatatttgaaaggtatgtt	8	1	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:117230480G>T	ENST00000003084.6	+	13	1885	c.1753G>T	c.(1753-1755)Gaa>Taa	p.E585*	CFTR_ENST00000454343.1_Nonsense_Mutation_p.E524*	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	585	ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AACAGAAAAAGAAATATTTGA	0.289									Cystic Fibrosis				16	24					0.000422831	0.000449533	1	1	0	T	117230480	G	T	117230480	4	4	48	1	0	0	0	0	0	1	0	0	3316	943	33	2	1803	2	CFTR	7	117230480	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	205625	117230480	41908183	1970	6364										
CTTNBP2	83992	broad.mit.edu	37	chr7	117417761	117417761	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtattctatggtacataagaAgcttgaggctgtccacatta	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:117417761A>C	ENST00000160373.3	-	8	2673	c.2582T>G	c.(2581-2583)cTt>cGt	p.L861R		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	861										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GTACATAAGAAGCTTGAGGCT	0.458													22	43					0	0	1	0	0	C	117417761	A	C	117417761	3	2	48	1	0	0	0	0	1	0	0	0	4069	72	3	4	2473	4	CTTNBP2	7	117417761	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	187281	117417761	41720902	1971	6365										
KCND2	3751	broad.mit.edu	37	chr7	119914842	119914842	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgtgagtggcacccgcttCcagacgtggcaggacaccct	12	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:119914842C>T	ENST00000331113.4	+	1	1121	c.156C>T	c.(154-156)ttC>ttT	p.F52F		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	52					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GCACCCGCTTCCAGACGTGGC	0.567													93	184					0	0	1	0	0	T	119914842	C	T	119914842	2	4	48	1	0	0	0	0	0	0	0	1	8062	854	30	3		3	KCND2	7	119914842	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2497081	119914842	39223821	1972	6366										
WNT16	51384	broad.mit.edu	37	chr7	120978941	120978941	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgttggtttcaggctgtcGccaagttgatgtcagtagac	12	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:120978941G>A	ENST00000222462.2	+	4	930	c.640G>A	c.(640-642)Gcc>Acc	p.A214T	WNT16_ENST00000361301.2_Missense_Mutation_p.A204T	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	214					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					TCAGGCTGTCGCCAAGTTGAT	0.418													16	43					0	0	1	0	0	A	120978941	G	A	120978941	3	1	48	1	0	0	0	0	1	0	0	0	17444	1087	38	1	723	1	WNT16	7	120978941	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1064099	120978941	38159722	1973	6367										
PTPRZ1	5803	broad.mit.edu	37	chr7	121651537	121651537	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttgaatccatcctgtctTcctatgatggtgcacctttg	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:121651537T>C	ENST00000393386.2	+	12	2848	c.2437T>C	c.(2437-2439)Tcc>Ccc	p.S813P	PTPRZ1_ENST00000483028.1_Intron|PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	813					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CATCCTGTCTTCCTATGATGG	0.458													71	103					0	0	1	0	0	C	121651537	T	C	121651537	3	2	48	1	0	0	0	0	1	0	0	0	12865	1783	62	4	2483	4	PTPRZ1	7	121651537	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	672596	121651537	37487126	1974	6368										
IQUB	154865	broad.mit.edu	37	chr7	123104994	123104994	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggttatgatgtttgactcCtctcatcataaggtcaacct	7	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:123104994C>A	ENST00000466202.1	-	10	2227	c.1651G>T	c.(1651-1653)Gga>Tga	p.G551*	IQUB_ENST00000434450.1_Nonsense_Mutation_p.G551*|IQUB_ENST00000324698.6_Nonsense_Mutation_p.G551*			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	551										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TGTTTGACTCCTCTCATCATA	0.313													27	60					2.61193e-14	3.39424e-14	1	1	0	A	123104994	C	A	123104994	4	1	48	1	0	0	0	0	0	1	0	0	7863	690	24	5	740	5	IQUB	7	123104994	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1453457	123104994	36033669	1975	6369										
LMOD2	442721	broad.mit.edu	37	chr7	123296133	123296133	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctagagagagagttggaagAcattgaacctgaccgcaacc	12	9	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:123296133A>G	ENST00000458573.2	+	1	273	c.116A>G	c.(115-117)gAc>gGc	p.D39G	LMOD2_ENST00000456238.2_Missense_Mutation_p.D39G	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	39	Glu-rich.|Tropomyosin-binding (By similarity).					cytoskeleton	actin binding|tropomyosin binding										GAGTTGGAAGACATTGAACCT	0.537													3	23					0	0	1	0	0	G	123296133	A	G	123296133	3	3	48	1	0	0	0	0	1	0	0	0	8897	275	10	4	118	4	LMOD2	7	123296133	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	191139	123296133	35842530	1976	6370										
WASL	8976	broad.mit.edu	37	chr7	123332489	123332489	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactgttctgctccacttttTttagctgagcaccctctcta	6	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:123332489T>G	ENST00000223023.4	-	9	1591	c.1259A>C	c.(1258-1260)aAa>aCa	p.K420T		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	420	WH2 1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTCCACTTTTTTTAGCTGAGC	0.493													24	37					0	0	1	0	0	G	123332489	T	G	123332489	3	3	48	1	0	0	0	0	1	0	0	0	17315	1841	64	4	270	4	WASL	7	123332489	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	36356	123332489	35806174	1977	6371										
GPR37	2861	broad.mit.edu	37	chr7	124404113	124404113	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaagatgatgagaaagtcCcagaaggccaggttggccaa	13	7	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:124404113C>A	ENST00000303921.2	-	1	1568	c.918G>T	c.(916-918)tgG>tgT	p.W306C		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	306						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TGAGAAAGTCCCAGAAGGCCA	0.552													25	116					4.26978e-12	5.35675e-12	1	1	0	A	124404113	C	A	124404113	3	1	48	1	0	0	0	0	1	0	0	0	6730	624	22	5	931	5	GPR37	7	124404113	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1071624	124404113	34734550	1978	6372										
GRM8	0	broad.mit.edu	37	chr7	126409928	126409928	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtaacttaccattaaaatTtacagcccgaatataaccaa	3	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:126409928T>G	ENST00000339582.2	-	7	2156	c.1348A>C	c.(1348-1350)Aat>Cat	p.N450H	GRM8_ENST00000358373.3_Missense_Mutation_p.N450H|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Missense_Mutation_p.N450H|GRM8_ENST00000405249.1_Missense_Mutation_p.N450H			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	450					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCATTAAAATTTACAGCCCGA	0.408										HNSCC(24;0.065)			4	47					0	0	1	0	0	G	126409928	T	G	126409928	3	3	48	1	0	0	0	0	1	0	0	0	6843	1841	64	4	1448	4	GRM8	7	126409928	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2005815	126409928	32728735	1979	6373										
GRM8	0	broad.mit.edu	37	chr7	126544109	126544109	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacaggtgctattttggatCcccaactatctgagccaatc	8	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:126544109C>A	ENST00000339582.2	-	5	1743	c.935G>T	c.(934-936)gGa>gTa	p.G312V	GRM8_ENST00000358373.3_Missense_Mutation_p.G312V|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Missense_Mutation_p.G312V|GRM8_ENST00000405249.1_Missense_Mutation_p.G312V			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	312					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TATTTTGGATCCCCAACTATC	0.403										HNSCC(24;0.065)			19	44					8.34094e-07	9.42356e-07	1	1	0	A	126544109	C	A	126544109	3	1	48	1	0	0	0	0	1	0	0	0	6843	855	30	2	1869	2	GRM8	7	126544109	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	134181	126544109	32594554	1980	6374										
FSCN3	29999	broad.mit.edu	37	chr7	127236471	127236471	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagccccactgtgcagcttCgttcagccaatggctactac	9	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:127236471C>T	ENST00000265825.5	+	3	1150	c.931C>T	c.(931-933)Cgt>Tgt	p.R311C	FSCN3_ENST00000420086.2_Missense_Mutation_p.R177C	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	311						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						TGTGCAGCTTCGTTCAGCCAA	0.522													49	102					0	0	1	0	0	T	127236471	C	T	127236471	3	4	48	1	0	0	0	0	1	0	0	0	6103	884	31	1	941	1	FSCN3	7	127236471	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	692362	127236471	31902192	1981	6375										
FSCN3	29999	broad.mit.edu	37	chr7	127239488	127239488	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgctccttccttgtattgCgaggtcgttatggctatgtg	11	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:127239488C>T	ENST00000265825.5	+	5	1393	c.1174C>T	c.(1174-1176)Cga>Tga	p.R392*	FSCN3_ENST00000420086.2_Nonsense_Mutation_p.R258*	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	392						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging	p.R392R(1)		endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						CCTTGTATTGCGAGGTCGTTA	0.517													4	87					0	0	1	0	0	T	127239488	C	T	127239488	4	4	48	1	0	0	0	0	0	1	0	0	6103	760	27	1	1192	1	FSCN3	7	127239488	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3017	127239488	31899175	1982	6376										
SND1	27044	broad.mit.edu	37	chr7	127721475	127721475	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtgctggaggagaaggagCgatctgctagctacaagccc	14	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:127721475C>T	ENST00000354725.3	+	18	2226	c.2032C>T	c.(2032-2034)Cga>Tga	p.R678*		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	678					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						GGAGAAGGAGCGATCTGCTAG	0.592													13	18					0	0	1	0	0	T	127721475	C	T	127721475	4	4	48	1	0	0	0	0	0	1	0	0	14897	760	27	1	2102	1	SND1	7	127721475	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	481987	127721475	31417188	1983	6377										
SND1	27044	broad.mit.edu	37	chr7	127726997	127726997	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttcctctgcagagagaggTcctgccatccacccgcctgg	11	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:127726997T>C	ENST00000354725.3	+	21	2506	c.2312T>C	c.(2311-2313)gTc>gCc	p.V771A		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	771	Tudor.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						CAGAGAGAGGTCCTGCCATCC	0.617													8	81					0	0	1	0	0	C	127726997	T	C	127726997	3	2	48	1	0	0	0	0	1	0	0	0	14897	1667	58	4	2394	4	SND1	7	127726997	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5522	127726997	31411666	1984	6378										
FAM71F2	346653	broad.mit.edu	37	chr7	128317859	128317859	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgcccaccaactccacaGaaacaacagtaagtgggcct	8	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:128317859G>A	ENST00000480462.1	+	3	713	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K	FAM71F2_ENST00000477515.1_Intron|FAM71F2_ENST00000460349.1_3'UTR|FAM71F2_ENST00000378704.3_Missense_Mutation_p.E194K			Q6NXP2	F71F2_HUMAN	family with sequence similarity 71, member F2	203										NS(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(2)	7						CAACTCCACAGAAACAACAGT	0.438													11	24					0	0	1	0	0	A	128317859	G	A	128317859	3	1	48	1	0	0	0	0	1	0	0	0	5647	943	33	3	617	3	FAM71F2	7	128317859	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	590862	128317859	30820804	1985	6379										
OPN1SW	611	broad.mit.edu	37	chr7	128415645	128415645	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaatgtagttgaggggcTgccgcaactttttgtagcgc	13	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:128415645T>C	ENST00000249389.2	-	1	199	c.200A>G	c.(199-201)cAg>cGg	p.Q67R		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	67					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						GTTGAGGGGCTGCCGCAACTT	0.537													52	118					0	0	1	0	0	C	128415645	T	C	128415645	3	2	48	1	0	0	0	0	1	0	0	0	10927	1580	55	4	866	4	OPN1SW	7	128415645	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	97786	128415645	30723018	1986	6380										
AHCYL2	23382	broad.mit.edu	37	chr7	129045047	129045047	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgttgccgtgaatcaattCttgatgggtaatgtttatta	9	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:129045047C>A	ENST00000325006.3	+	8	1189	c.1135C>A	c.(1135-1137)Ctt>Att	p.L379I	AHCYL2_ENST00000446544.2_Missense_Mutation_p.L378I|AHCYL2_ENST00000531335.2_Missense_Mutation_p.L298I|AHCYL2_ENST00000446212.1_Missense_Mutation_p.L277I|AHCYL2_ENST00000474594.1_Missense_Mutation_p.L276I|AHCYL2_ENST00000490911.1_Missense_Mutation_p.L276I	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	379					one-carbon metabolic process		adenosylhomocysteinase activity	p.L379I(1)|p.L276I(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						TGAATCAATTCTTGATGGGTA	0.393													25	128					3.6726e-16	4.87283e-16	1	1	0	A	129045047	C	A	129045047	3	1	48	1	0	0	0	0	1	0	0	0	408	913	32	2	1287	2	AHCYL2	7	129045047	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	629402	129045047	30093616	1987	6381										
PLXNA4	91584	broad.mit.edu	37	chr7	131866291	131866291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaagccaaactcctcgggcCtctcggtcaggtctgactgg	12	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:131866291C>T	ENST00000359827.3	-	18	4303	c.3341G>A	c.(3340-3342)aGg>aAg	p.R1114K	PLXNA4_ENST00000321063.4_Missense_Mutation_p.R1114K			Q9HCM2	PLXA4_HUMAN	plexin A4	1114	IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CTCCTCGGGCCTCTCGGTCAG	0.577													32	70					0	0	1	0	0	T	131866291	C	T	131866291	3	4	48	1	0	0	0	0	1	0	0	0	12169	681	24	3	2403	3	PLXNA4	7	131866291	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2821244	131866291	27272372	1988	6382										
PLXNA4	91584	broad.mit.edu	37	chr7	131872281	131872281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaccaccacgttgcttccgGcattcaggttggtgcctgtg	11	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:131872281G>A	ENST00000359827.3	-	15	3904	c.2942C>T	c.(2941-2943)gCc>gTc	p.A981V	PLXNA4_ENST00000321063.4_Missense_Mutation_p.A981V			Q9HCM2	PLXA4_HUMAN	plexin A4	981	IPT/TIG 2.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GTTGCTTCCGGCATTCAGGTT	0.562													24	271					0	0	1	0	0	A	131872281	G	A	131872281	3	1	48	1	0	0	0	0	1	0	0	0	12169	1203	42	3	2814	3	PLXNA4	7	131872281	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5990	131872281	27266382	1989	6383										
PLXNA4	91584	broad.mit.edu	37	chr7	131912214	131912214	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctccgggatgctcaccattCtctgtgatgatccggggcac	11	14	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:131912214C>A	ENST00000359827.3	-	7	2840	c.1878G>T	c.(1876-1878)gaG>gaT	p.E626D	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E626D			Q9HCM2	PLXA4_HUMAN	plexin A4	626						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCTCACCATTCTCTGTGATGA	0.572													8	22					0.000157383	0.000169016	1	1	0	A	131912214	C	A	131912214	3	1	48	1	0	0	0	0	1	0	0	0	12169	912	32	2	3910	2	PLXNA4	7	131912214	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	39933	131912214	27226449	1990	6384										
CNOT4	4850	broad.mit.edu	37	chr7	135078870	135078870	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgctgctgaaattgagggAacctctggggcaagactgaa	15	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:135078870A>G	ENST00000428680.2	-	10	1697	c.1418T>C	c.(1417-1419)tTc>tCc	p.F473S	CNOT4_ENST00000451834.1_Missense_Mutation_p.F473S|CNOT4_ENST00000541284.1_Missense_Mutation_p.F476S|CNOT4_ENST00000356162.4_Intron|CNOT4_ENST00000361528.4_Missense_Mutation_p.F473S|CNOT4_ENST00000414802.1_Intron|CNOT4_ENST00000423368.2_Missense_Mutation_p.F476S|CNOT4_ENST00000315544.5_Missense_Mutation_p.F476S	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	476					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						AAATTGAGGGAACCTCTGGGG	0.502													30	52					0	0	1	0	0	G	135078870	A	G	135078870	3	3	48	1	0	0	0	0	1	0	0	0	3644	246	9	4	614	4	CNOT4	7	135078870	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3166656	135078870	24059793	1991	6385										
CHRM2	1129	broad.mit.edu	37	chr7	136700079	136700079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctctttcatcctctgggCtccagccattctcttctggc	6	17	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:136700079C>T	ENST00000445907.2	+	3	995	c.467C>T	c.(466-468)gCt>gTt	p.A156V	CHRM2_ENST00000401861.1_Missense_Mutation_p.A156V|CHRM2_ENST00000397608.3_Missense_Mutation_p.A156V|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000439694.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.A156V|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.A156V|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000592183.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.A156V|AC009264.1_ENST00000425981.2_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	156					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ATCCTCTGGGCTCCAGCCATT	0.498													6	97					0	0	1	0	0	T	136700079	C	T	136700079	3	4	48	1	0	0	0	0	1	0	0	0	3399	797	28	3	469	3	CHRM2	7	136700079	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1621209	136700079	22438584	1992	6386										
SVOPL	136306	broad.mit.edu	37	chr7	138329467	138329467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggccagcactcaccaggaCgggctccaccagcttcccct	11	18	1	0	rs143599875		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:138329467C>T	ENST00000421622.1	-	5	632	c.424G>A	c.(424-426)Gtc>Atc	p.V142I	SVOPL_ENST00000288513.5_Missense_Mutation_p.V110I|SVOPL_ENST00000436657.1_Missense_Mutation_p.V110I|SVOPL_ENST00000419765.3_Missense_Mutation_p.V262I			Q8N434	SVOPL_HUMAN	SVOP-like	262						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						CTCACCAGGACGGGCTCCACC	0.637													16	49					0	0	1	0	0	T	138329467	C	T	138329467	3	4	48	1	0	0	0	0	1	0	0	0	15479	536	19	1	726	1	SVOPL	7	138329467	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1629388	138329467	20809196	1993	6387										
KIAA1549	57670	broad.mit.edu	37	chr7	138601497	138601497	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaagctgggccttaccagTtgtgatcagataggcatcgg	14	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:138601497T>G	ENST00000440172.1	-	2	2923	c.2875A>C	c.(2875-2877)Act>Cct	p.T959P	KIAA1549_ENST00000242365.4_Missense_Mutation_p.T909P|KIAA1549_ENST00000422774.1_Missense_Mutation_p.T959P	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	959						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						GCCTTACCAGTTGTGATCAGA	0.537			O	BRAF	pilocytic astrocytoma								8	26					0	0	1	0	0	G	138601497	T	G	138601497	3	3	48	1	0	0	0	0	1	0	0	0	8285	1725	60	4	3053	4	KIAA1549	7	138601497	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	272030	138601497	20537166	1994	6388										
TTC26	79989	broad.mit.edu	37	chr7	138845780	138845780	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaatctggtgaataacgaTttcccgtcttgactgagttc	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:138845780T>G	ENST00000474035.2	+	8	884	c.804T>G	c.(802-804)gaT>gaG	p.D268E	TTC26_ENST00000343187.4_Intron|TTC26_ENST00000481482.1_Intron|TTC26_ENST00000478836.2_Intron|TTC26_ENST00000430935.1_Intron|TTC26_ENST00000464848.1_Intron|TTC26_ENST00000495038.1_Intron			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	384							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						TGAATAACGATTTCCCGTCTT	0.393													7	15					0	0	1	0	0	G	138845780	T	G	138845780	3	3	48	1	0	0	0	0	1	0	0	0	16755	1508	52	4		4	TTC26	7	138845780	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	244283	138845780	20292883	1995	6389										
ADCK2	90956	broad.mit.edu	37	chr7	140380894	140380894	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaattcccgtggacttgaAaaggaagattgcacggctgg	14	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:140380894A>C	ENST00000072869.4	+	4	1440	c.1262A>C	c.(1261-1263)aAa>aCa	p.K421T	ADCK2_ENST00000476491.1_Missense_Mutation_p.K421T	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	421	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					GTGGACTTGAAAAGGAAGATT	0.562													23	52					0	0	1	0	0	C	140380894	A	C	140380894	3	2	48	1	0	0	0	0	1	0	0	0	288	14	1	4	1276	4	ADCK2	7	140380894	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1535114	140380894	18757769	1996	6390										
MRPS33	51650	broad.mit.edu	37	chr7	140710232	140710232	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatcacctgtagagtccaaGaaatcggagcgtctgcatga	10	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:140710232G>T	ENST00000393008.3	-	2	357	c.202C>A	c.(202-204)Ctt>Att	p.L68I	MRPS33_ENST00000469351.1_Missense_Mutation_p.L68I|MRPS33_ENST00000496958.1_Missense_Mutation_p.L68I|MRPS33_ENST00000324787.5_Missense_Mutation_p.L68I|MRPS33_ENST00000467334.1_Missense_Mutation_p.L58I	NM_016071.3	NP_057155.1	Q9Y291	RT33_HUMAN	mitochondrial ribosomal protein S33	68					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			breast(2)|endometrium(1)|kidney(1)	4	Melanoma(164;0.00956)					TAGAGTCCAAGAAATCGGAGC	0.413													23	38					4.7796e-09	5.70246e-09	1	1	0	T	140710232	G	T	140710232	3	4	48	1	0	0	0	0	1	0	0	0	9890	942	33	2	126	2	MRPS33	7	140710232	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	329338	140710232	18428431	1997	6391										
AGK	55750	broad.mit.edu	37	chr7	141321537	141321537	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttttctcttttagacataTtactgatgccacacttgcca	4	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:141321537T>G	ENST00000355413.4	+	9	784	c.524T>G	c.(523-525)aTt>aGt	p.I175S	AGK_ENST00000473247.1_Missense_Mutation_p.I147S|AGK_ENST00000535825.1_Missense_Mutation_p.I172S	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	175	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					TTTAGACATATTACTGATGCC	0.388													3	38					0	0	1	0	0	G	141321537	T	G	141321537	3	3	48	1	0	0	0	0	1	0	0	0	380	1493	52	4	554	4	AGK	7	141321537	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	611305	141321537	17817126	1998	6392										
TAS2R3	50831	broad.mit.edu	37	chr7	141464029	141464029	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacactgggaattctggtcaAttgtttcattgagttggtca	10	7	4	1	rs146979075	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:141464029A>C	ENST00000247879.2	+	1	133	c.71A>C	c.(70-72)aAt>aCt	p.N24T	SSBP1_ENST00000465582.1_Intron	NM_016943.2	NP_058639.1	Q9NYW6	TA2R3_HUMAN	taste receptor, type 2, member 3	24					sensory perception of taste		taste receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)	14	Melanoma(164;0.0171)					ATTCTGGTCAATTGTTTCATT	0.473													54	114					0	0	1	0	0	C	141464029	A	C	141464029	3	2	48	1	0	0	0	0	1	0	0	0	15628	101	4	4	73	4	TAS2R3	7	141464029	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	142492	141464029	17674634	1999	6393										
CLEC5A	23601	broad.mit.edu	37	chr7	141631561	141631561	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgatccaacgccaccttttCtcttcacgatggtaaattaa	5	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:141631561C>A	ENST00000546910.1	-	6	607	c.411G>T	c.(409-411)gaG>gaT	p.E137D	CLEC5A_ENST00000470595.1_5'UTR|CLEC5A_ENST00000438351.1_Missense_Mutation_p.E114D|MGAM_ENST00000497554.1_3'UTR|CLEC5A_ENST00000551012.2_Missense_Mutation_p.E114D|CLEC5A_ENST00000439991.1_Missense_Mutation_p.E33D	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	137	C-type lectin.				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					GCCACCTTTTCTCTTCACGAT	0.388													35	66					7.61001e-30	1.08524e-29	1	1	0	A	141631561	C	A	141631561	3	1	48	1	0	0	0	0	1	0	0	0	3542	912	32	2	163	2	CLEC5A	7	141631561	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	167532	141631561	17507102	2000	6394										
MGAM	8972	broad.mit.edu	37	chr7	141705362	141705362	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagctgaaaaaatttactaCtttggagattgtgctcagtg	10	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:141705362C>A	ENST00000475668.2	+	2	86	c.32C>A	c.(31-33)aCt>aAt	p.T11N	MGAM_ENST00000549489.2_Missense_Mutation_p.T11N			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	11					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AAATTTACTACTTTGGAGATT	0.299													5	4					0.0215528	0.0219788	1	1	0	A	141705362	C	A	141705362	3	1	48	1	0	0	0	0	1	0	0	0	9590	565	20	5	34	5	MGAM	7	141705362	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	73801	141705362	17433301	2001	6395										
MGAM	8972	broad.mit.edu	37	chr7	141727464	141727464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcttggatttcacctcagtCgttacgaatatggaacctta	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:141727464C>T	ENST00000475668.2	+	10	1204	c.1150C>T	c.(1150-1152)Cgt>Tgt	p.R384C	MGAM_ENST00000549489.2_Missense_Mutation_p.R384C			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	384	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCACCTCAGTCGTTACGAATA	0.453													12	17					0	0	1	0	0	T	141727464	C	T	141727464	3	4	48	1	0	0	0	0	1	0	0	0	9590	884	31	1	1184	1	MGAM	7	141727464	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22102	141727464	17411199	2002	6396										
KEL	3792	broad.mit.edu	37	chr7	142651036	142651036	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaccagtcgatggcggggGccatttccttagaggaggga	15	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:142651036G>A	ENST00000355265.2	-	9	1406	c.932C>T	c.(931-933)gCc>gTc	p.A311V	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	311					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GATGGCGGGGGCCATTTCCTT	0.527													32	66					0	0	1	0	0	A	142651036	G	A	142651036	3	1	48	1	0	0	0	0	1	0	0	0	8184	1203	42	3	1310	3	KEL	7	142651036	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	923572	142651036	16487627	2003	6397										
EPHA1	2041	broad.mit.edu	37	chr7	143098425	143098425	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggaagcagcaccttctggaAcaagggccgtcggagctgaa	15	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:143098425A>G	ENST00000275815.3	-	3	510	c.424T>C	c.(424-426)Ttc>Ctc	p.F142L		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	142						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				ACCTTCTGGAACAAGGGCCGT	0.592													42	78					0	0	1	0	0	G	143098425	A	G	143098425	3	3	48	1	0	0	0	0	1	0	0	0	5193	43	2	4	2570	4	EPHA1	7	143098425	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	447389	143098425	16040238	2004	6398										
OR6B1	135946	broad.mit.edu	37	chr7	143701692	143701692	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgagttggtagactttatCctggcactggtcatcttcct	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:143701692C>A	ENST00000408922.2	+	1	671	c.603C>A	c.(601-603)atC>atA	p.I201I		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TAGACTTTATCCTGGCACTGG	0.458													25	92					1.55469e-16	2.07108e-16	1	1	0	A	143701692	C	A	143701692	2	1	48	1	0	0	0	0	0	0	0	1	11233	845	30	2		2	OR6B1	7	143701692	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	603267	143701692	15436971	2005	6399										
OR2A2	442361	broad.mit.edu	37	chr7	143807156	143807156	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtccctggtacatgaaattCtccttctaaggttgcccttc	7	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:143807156C>A	ENST00000408979.2	+	1	550	c.481C>A	c.(481-483)Ctc>Atc	p.L161I		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					ACATGAAATTCTCCTTCTAAG	0.532													33	59					1.08312e-15	1.43e-15	1	1	0	A	143807156	C	A	143807156	3	1	48	1	0	0	0	0	1	0	0	0	11024	913	32	2	483	2	OR2A2	7	143807156	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	105464	143807156	15331507	2006	6400										
ARHGEF5	7984	broad.mit.edu	37	chr7	144060321	144060321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagatattattctccctgcGaagagcatcctgcagagacc	8	13	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:144060321G>A	ENST00000056217.5	+	2	733	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	187					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					TTCTCCCTGCGAAGAGCATCC	0.507													40	117					0	0	1	0	0	A	144060321	G	A	144060321	3	1	48	1	0	0	0	0	1	0	0	0	906	1059	37	1	561	1	ARHGEF5	7	144060321	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	253165	144060321	15078342	2007	6401										
ARHGEF5	7984	broad.mit.edu	37	chr7	144075919	144075919	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgatgaattggcactggaGaaagccgacgtggtgatggt	15	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:144075919G>T	ENST00000056217.5	+	14	4770	c.4596G>T	c.(4594-4596)gaG>gaT	p.E1532D	ARHGEF5_ENST00000471847.2_Missense_Mutation_p.E454D	NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	1532	SH3.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					TGGCACTGGAGAAAGCCGACG	0.577													67	138					1.05635e-38	1.52265e-38	1	1	0	T	144075919	G	T	144075919	3	4	48	1	0	0	0	0	1	0	0	0	906	933	33	2	4646	2	ARHGEF5	7	144075919	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	15598	144075919	15062744	2008	6402										
CNTNAP2	26047	broad.mit.edu	37	chr7	146818172	146818172	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtcattgagcgccaggggCggagcattaacctcactctg	13	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:146818172C>A	ENST00000361727.3	+	6	1372	c.856C>A	c.(856-858)Cgg>Agg	p.R286R		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	286	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCGCCAGGGGCGGAGCATTAA	0.522										HNSCC(39;0.1)			15	56					7.93312e-07	8.98086e-07	1	1	0	A	146818172	C	A	146818172	2	1	48	1	0	0	0	0	0	0	0	1	3670	759	27	5		5	CNTNAP2	7	146818172	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2742253	146818172	12320491	2009	6403										
CNTNAP2	26047	broad.mit.edu	37	chr7	147869473	147869473	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccattgcaccagctatggAacaaactgtgaaaatggagg	12	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:147869473A>C	ENST00000361727.3	+	18	3429	c.2913A>C	c.(2911-2913)ggA>ggC	p.G971G	CNTNAP2_ENST00000538075.1_Silent_p.G30G	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	971	EGF-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCAGCTATGGAACAAACTGTG	0.473										HNSCC(39;0.1)			25	57					0	0	1	0	0	C	147869473	A	C	147869473	2	2	48	1	0	0	0	0	0	0	0	1	3670	233	9	4		4	CNTNAP2	7	147869473	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1051301	147869473	11269190	2010	6404										
EZH2	0	broad.mit.edu	37	chr7	148543633	148543633	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatccttcgctgtttccattCttggtttaagatttccgttc	6	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:148543633C>A	ENST00000320356.2	-	3	296	c.175G>T	c.(175-177)Gaa>Taa	p.E59*	EZH2_ENST00000350995.2_Nonsense_Mutation_p.E59*|EZH2_ENST00000478654.1_Nonsense_Mutation_p.E59*|EZH2_ENST00000476773.1_Nonsense_Mutation_p.E59*|EZH2_ENST00000460911.1_Nonsense_Mutation_p.E59*|EZH2_ENST00000536783.1_5'UTR|EZH2_ENST00000483967.1_Nonsense_Mutation_p.E59*|EZH2_ENST00000541220.1_Nonsense_Mutation_p.E59*	NM_001203247.1|NM_001203248.1|NM_004456.4	NP_001190176.1|NP_001190177.1|NP_004447.2	Q15910	EZH2_HUMAN	enhancer of zeste homolog 2 (Drosophila)	59	Interaction with DNMT1, DNMT3A and DNMT3B.|Interaction with EED (By similarity).				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(313)|kidney(3)|large_intestine(8)|liver(1)|lung(23)|parathyroid(2)|skin(3)|upper_aerodigestive_tract(3)	359	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TGTTTCCATTCTTGGTTTAAG	0.383			Mis		DLBCL								21	29					1.28384e-07	1.48174e-07	1	1	0	A	148543633	C	A	148543633	4	1	48	1	0	0	0	0	0	1	0	0	5362	922	32	2	2152	2	EZH2	7	148543633	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	674160	148543633	10595030	2011	6405										
ZNF212	7988	broad.mit.edu	37	chr7	148947339	148947339	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctattttcagaccaccgaGatttcactctggacggtggt	9	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:148947339G>A	ENST00000335870.2	+	2	242	c.114G>A	c.(112-114)gaG>gaA	p.E38E		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			AGACCACCGAGATTTCACTCT	0.542													24	30					0	0	1	0	0	A	148947339	G	A	148947339	2	1	48	1	0	0	0	0	0	0	0	1	17825	933	33	3		3	ZNF212	7	148947339	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	403706	148947339	10191324	2012	6406										
SSPO	23145	broad.mit.edu	37	chr7	149491951	149491951	+	RNA	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccagtccccagatcagatTccctttggccacttacattc	5	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:149491951T>G	ENST00000378016.2	+	0	6152							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGATCAGATTCCCTTTGGCC	0.612													28	45					0	0	1	0	0	G	149491951	T	G	149491951	1	3	48	0	1	0	0	0	0	0	0	0	15244	1783	62	4		4	SSPO	7	149491951	RNA	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	544612	149491951	9646712	2013	6407										
SSPO	23145	broad.mit.edu	37	chr7	149495167	149495167	+	RNA	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctgcagggcctggcagaGactgagcactggccccctgg	14	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:149495167G>T	ENST00000378016.2	+	0	6915							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCTGGCAGAGACTGAGCACT	0.667													23	34					1.85244e-09	2.22951e-09	1	1	0	T	149495167	G	T	149495167	1	4	48	0	1	0	0	0	0	0	0	0	15244	933	33	2		2	SSPO	7	149495167	RNA	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3216	149495167	9643496	2014	6408										
GIMAP8	155038	broad.mit.edu	37	chr7	150164222	150164222	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggggatgacttgctgcaaGatttcattgaaaaaaacaaa	10	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:150164222G>T	ENST00000307271.3	+	2	1010	c.436G>T	c.(436-438)Gat>Tat	p.D146Y		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	146						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CTTGCTGCAAGATTTCATTGA	0.438													24	44					2.21704e-12	2.79328e-12	1	1	0	T	150164222	G	T	150164222	3	4	48	1	0	0	0	0	1	0	0	0	6426	942	33	2	438	2	GIMAP8	7	150164222	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	669055	150164222	8974441	2015	6409										
GIMAP7	168537	broad.mit.edu	37	chr7	150217465	150217465	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatcttgttcactcgcaaaGaagagttggagggccagagc	12	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:150217465G>T	ENST00000313543.4	+	2	560	c.403G>T	c.(403-405)Gaa>Taa	p.E135*		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	135							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACTCGCAAAGAAGAGTTGGA	0.527													12	47					2.27111e-07	2.60515e-07	1	1	0	T	150217465	G	T	150217465	4	4	48	1	0	0	0	0	0	1	0	0	6425	943	33	2	405	2	GIMAP7	7	150217465	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53243	150217465	8921198	2016	6410										
NOS3	4846	broad.mit.edu	37	chr7	150692348	150692348	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaagttccctcgtgtgaaGaactgggaggtggggagcat	15	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:150692348G>T	ENST00000297494.3	+	3	573	c.216G>T	c.(214-216)aaG>aaT	p.K72N	NOS3_ENST00000484524.1_Missense_Mutation_p.K72N|NOS3_ENST00000461406.1_5'UTR|NOS3_ENST00000467517.1_Missense_Mutation_p.K72N	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	72					anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTCGTGTGAAGAACTGGGAGG	0.642													12	29					5.50884e-06	6.10489e-06	1	1	0	T	150692348	G	T	150692348	3	4	48	1	0	0	0	0	1	0	0	0	10590	933	33	2	222	2	NOS3	7	150692348	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	474883	150692348	8446315	2017	6411										
NOS3	4846	broad.mit.edu	37	chr7	150698909	150698909	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaccttcctctcccgcagCgccgtgaagatctccgcctc	7	20	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:150698909C>T	ENST00000297494.3	+	13	1860	c.1502_splice	c.e13-1	p.N501_splice	NOS3_ENST00000484524.1_Splice_Site_p.N501_splice|NOS3_ENST00000461406.1_Splice_Site_p.N295_splice|NOS3_ENST00000467517.1_Splice_Site_p.N501_splice	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	501	Calmodulin-binding (Potential).				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TCTCCCGCAGCGCCGTGAAGA	0.642													19	22					0	0	1	0	0	T	150698909	C	T	150698909	5	4	48	1	0	0	0	0	0	0	1	0	10590	782	27	1	1549	1	NOS3	7	150698909	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6561	150698909	8439754	2018	6412										
ABCB8	11194	broad.mit.edu	37	chr7	150739111	150739111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgggaagctggaagcttccGatgaagaggtgtacacagcc	14	8	0	2	rs144722322	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:150739111G>A	ENST00000358849.4	+	14	1774	c.1681G>A	c.(1681-1683)Gat>Aat	p.D561N	ABCB8_ENST00000542328.1_Missense_Mutation_p.D473N|ABCB8_ENST00000498578.1_Missense_Mutation_p.D561N|ABCB8_ENST00000356058.4_3'UTR|ABCB8_ENST00000297504.6_Missense_Mutation_p.D578N	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	578	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.D561N(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAAGCTTCCGATGAAGAGGT	0.577													30	52					0	0	1	0	0	A	150739111	G	A	150739111	3	1	48	1	0	0	0	0	1	0	0	0	47	1058	37	1	1735	1	ABCB8	7	150739111	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40202	150739111	8399552	2019	6413										
XRCC2	7516	broad.mit.edu	37	chr7	152346402	152346402	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgttaggtgataaagcatTtctgtttttcctgttccttc	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:152346402T>G	ENST00000359321.1	-	3	253	c.168A>C	c.(166-168)gaA>gaC	p.E56D	XRCC2_ENST00000495707.1_5'UTR	NM_005431.1	NP_005422.1	O43543	XRCC2_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 2	56					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			NS(1)|breast(1)|large_intestine(5)|liver(1)|lung(1)|prostate(2)	11		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		GATAAAGCATTTCTGTTTTTC	0.373								Homologous recombination					25	36					0	0	1	0	0	G	152346402	T	G	152346402	3	3	48	1	0	0	0	0	1	0	0	0	17512	1838	64	4	678	4	XRCC2	7	152346402	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1607291	152346402	6792261	2020	6414										
DPP6	1804	broad.mit.edu	37	chr7	154593165	154593165	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatcacatcacggtgtcctCgtcccaggtaagtcctgcta	8	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:154593165C>T	ENST00000404039.1	+	13	1795	c.1208C>T	c.(1207-1209)tCg>tTg	p.S403L	DPP6_ENST00000427557.1_Missense_Mutation_p.S360L|DPP6_ENST00000377770.3_Missense_Mutation_p.S467L|DPP6_ENST00000332007.3_Missense_Mutation_p.S405L	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	467					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ACGGTGTCCTCGTCCCAGGTA	0.537													5	7					0	0	1	0	0	T	154593165	C	T	154593165	3	4	48	1	0	0	0	0	1	0	0	0	4756	893	31	1	1566	1	DPP6	7	154593165	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2246763	154593165	4545498	2021	6415										
DPP6	1804	broad.mit.edu	37	chr7	154667694	154667694	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatggtgagcagccacggCgcggtggtggtaaagtgtga	19	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:154667694C>T	ENST00000404039.1	+	20	2357	c.1770C>T	c.(1768-1770)ggC>ggT	p.G590G	DPP6_ENST00000427557.1_Silent_p.G547G|DPP6_ENST00000377770.3_Silent_p.G654G|DPP6_ENST00000332007.3_Silent_p.G592G	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	654					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GCAGCCACGGCGCGGTGGTGG	0.647													13	23					0	0	1	0	0	T	154667694	C	T	154667694	2	4	48	1	0	0	0	0	0	0	0	1	4756	755	27	1		1	DPP6	7	154667694	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	74529	154667694	4470969	2022	6416										
RNF32	140545	broad.mit.edu	37	chr7	156450909	156450909	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaaacccgagtgatacacGatggggcccgcctgttcaga	11	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:156450909G>A	ENST00000392741.2	+	5	626	c.538G>A	c.(538-540)Gat>Aat	p.D180N	RNF32_ENST00000405335.1_Missense_Mutation_p.D180N|RNF32_ENST00000343665.4_Missense_Mutation_p.D156N|RNF32_ENST00000392743.2_Missense_Mutation_p.D180N|RNF32_ENST00000480011.1_3'UTR|RNF32_ENST00000317955.5_Missense_Mutation_p.D180N|RNF32_ENST00000311822.8_Missense_Mutation_p.D180N|RNF32_ENST00000432459.2_Missense_Mutation_p.D180N			Q9H0A6	RNF32_HUMAN	ring finger protein 32	180						aggresome|endosome	protein binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(2)	15	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		AGTGATACACGATGGGGCCCG	0.473													17	33					0	0	1	0	0	A	156450909	G	A	156450909	3	1	48	1	0	0	0	0	1	0	0	0	13539	1058	37	1	556	1	RNF32	7	156450909	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1783215	156450909	2687754	2023	6417										
RNF32	140545	broad.mit.edu	37	chr7	156451252	156451252	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccaagttaagaaaaaaattCtttgaaaaaaaggtaggtaa	8	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr7:156451252C>A	ENST00000392741.2	+	6	760	c.672C>A	c.(670-672)ttC>ttA	p.F224L	RNF32_ENST00000405335.1_Missense_Mutation_p.F224L|RNF32_ENST00000343665.4_Missense_Mutation_p.F200L|RNF32_ENST00000392743.2_Missense_Mutation_p.F224L|RNF32_ENST00000480011.1_3'UTR|RNF32_ENST00000317955.5_Missense_Mutation_p.F224L|RNF32_ENST00000311822.8_Missense_Mutation_p.F224L|RNF32_ENST00000432459.2_Missense_Mutation_p.F224L			Q9H0A6	RNF32_HUMAN	ring finger protein 32	224						aggresome|endosome	protein binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(2)	15	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GAAAAAAATTCTTTGAAAAAA	0.423													14	25					3.27435e-08	3.83577e-08	1	1	0	A	156451252	C	A	156451252	3	1	48	1	0	0	0	0	1	0	0	0	13539	912	32	2	694	2	RNF32	7	156451252	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	343	156451252	2687411	2024	6418										
CSMD1	64478	broad.mit.edu	37	chr8	2796122	2796122	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagggctataccactgtacaGactgtgttcagagttgtgtc	12	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:2796122G>T	ENST00000520002.1	-	71	11238	c.10683C>A	c.(10681-10683)gtC>gtA	p.V3561V	CSMD1_ENST00000602723.1_Silent_p.V3384V|CSMD1_ENST00000400186.3_Silent_p.V3384V|CSMD1_ENST00000602557.1_Silent_p.V3561V|CSMD1_ENST00000537824.1_Silent_p.V3560V|CSMD1_ENST00000542608.1_Silent_p.V3383V			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3561						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCACTGTACAGACTGTGTTCA	0.468													3	14					1	1	1	1	0	T	2796122	G	T	2796122	2	4	48	1	0	0	0	0	0	0	0	1	3969	929	33	2		2	CSMD1	8	2796122	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		2796122	143567900	2025	6419										
MCPH1	79648	broad.mit.edu	37	chr8	6302632	6302632	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaatgtctgatttttcctgCgttggcaaaaaaaccagaac	8	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:6302632C>T	ENST00000344683.5	+	8	1465	c.1389C>T	c.(1387-1389)tgC>tgT	p.C463C	MCPH1_ENST00000522905.1_Silent_p.C415C|MCPH1_ENST00000519480.1_Silent_p.C463C	NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	463						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		ATTTTTCCTGCGTTGGCAAAA	0.443													23	40					0	0	1	0	0	T	6302632	C	T	6302632	2	4	48	1	0	0	0	0	0	0	0	1	9447	776	27	1		1	MCPH1	8	6302632	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3506510	6302632	140061390	2026	6420										
ERI1	90459	broad.mit.edu	37	chr8	8873895	8873895	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgtctgatttctgcatcAgtctaactggaattactcag	8	9	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:8873895A>G	ENST00000523898.1	+	5	1241	c.562A>G	c.(562-564)Agt>Ggt	p.S188G	ERI1_ENST00000520332.1_3'UTR|ERI1_ENST00000519292.1_Missense_Mutation_p.S188G|ERI1_ENST00000250263.7_Missense_Mutation_p.S188G			Q8IV48	ERI1_HUMAN	exoribonuclease 1	188	Exonuclease.				gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11					Adenosine monophosphate(DB00131)	TTTCTGCATCAGTCTAACTGG	0.318													22	41					0	0	1	0	0	G	8873895	A	G	8873895	3	3	48	1	0	0	0	0	1	0	0	0	5255	188	7	4	576	4	ERI1	8	8873895	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2571263	8873895	137490127	2027	6421										
GATA4	2626	broad.mit.edu	37	chr8	11614543	11614543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagatgcgtcccatcaagaCggagcctggcctgtcatctc	12	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:11614543C>T	ENST00000335135.4	+	6	1655	c.1097C>T	c.(1096-1098)aCg>aTg	p.T366M	GATA4_ENST00000528712.1_Missense_Mutation_p.T160M|GATA4_ENST00000532059.1_Missense_Mutation_p.T367M	NM_002052.3	NP_002043.2	P43694	GATA4_HUMAN	GATA binding protein 4	366					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding	p.T366K(1)		central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(10)	13	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CCCATCAAGACGGAGCCTGGC	0.657													39	76					0	0	1	0	0	T	11614543	C	T	11614543	3	4	48	1	0	0	0	0	1	0	0	0	6295	536	19	1	1115	1	GATA4	8	11614543	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2740648	11614543	134749479	2028	6422										
LONRF1	91694	broad.mit.edu	37	chr8	12594474	12594474	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcctgttctaaaagagacAactttcttttcagcagaaca	5	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:12594474A>C	ENST00000398246.3	-	5	1358	c.1289T>G	c.(1288-1290)tTg>tGg	p.L430W	LONRF1_ENST00000533751.1_Missense_Mutation_p.L73W	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	430					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		TAAAAGAGACAACTTTCTTTT	0.338													4	45					0	0	1	0	0	C	12594474	A	C	12594474	3	2	48	1	0	0	0	0	1	0	0	0	8938	131	5	4	1064	4	LONRF1	8	12594474	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	979931	12594474	133769548	2029	6423										
TUSC3	7991	broad.mit.edu	37	chr8	15508212	15508212	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attattcttatcaggcaagcTaatgaagaatatcaaatact	5	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:15508212T>G	ENST00000382020.4	+	3	523	c.315T>G	c.(313-315)gcT>gcG	p.A105A	TUSC3_ENST00000509380.1_Silent_p.A105A|TUSC3_ENST00000503191.1_Intron|TUSC3_ENST00000506802.1_Silent_p.A105A|TUSC3_ENST00000503731.1_Silent_p.A105A	NM_178234.2	NP_839952.1	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3	105					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(10)|ovary(2)	28				Colorectal(111;0.113)		TCAGGCAAGCTAATGAAGAAT	0.423													54	88					0	0	1	0	0	G	15508212	T	G	15508212	2	3	48	1	0	0	0	0	0	0	0	1	16839	1509	53	4		4	TUSC3	8	15508212	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2913738	15508212	130855810	2030	6424										
ZDHHC2	51201	broad.mit.edu	37	chr8	17074756	17074756	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaattcatactttataaaaGtacgataattttccctttat	2	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:17074756G>T	ENST00000262096.8	+	12	1833		c.e12+1			NM_016353.4	NP_057437.1	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2							integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|pancreas(1)|stomach(1)	8				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		CTTTATAAAAGTACGATAATT	0.269													10	11					3.86212e-05	4.21111e-05	1	1	0	T	17074756	G	T	17074756	5	4	48	1	0	0	0	0	0	0	1	0	17667	1043	36	5		5	ZDHHC2	8	17074756	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1566544	17074756	129289266	2031	6425										
MTUS1	57509	broad.mit.edu	37	chr8	17507410	17507410	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgcagtttctcattcttgAtctctaacacagctttcagg	7	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:17507410A>C	ENST00000381869.3	-	12	3757	c.3284T>G	c.(3283-3285)aTc>aGc	p.I1095S	MTUS1_ENST00000519263.1_Missense_Mutation_p.I1095S|MTUS1_ENST00000262102.6_Missense_Mutation_p.I1149S|MTUS1_ENST00000381861.3_Missense_Mutation_p.I396S|MTUS1_ENST00000400046.1_Missense_Mutation_p.I221S|MTUS1_ENST00000544260.1_Missense_Mutation_p.I294S|MTUS1_ENST00000297488.6_Missense_Mutation_p.I315S|MTUS1_ENST00000518713.1_5'UTR	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	1149						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CTCATTCTTGATCTCTAACAC	0.378													29	56					0	0	1	0	0	C	17507410	A	C	17507410	3	2	48	1	0	0	0	0	1	0	0	0	10012	333	12	4	378	4	MTUS1	8	17507410	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	432654	17507410	128856612	2032	6426										
MTUS1	57509	broad.mit.edu	37	chr8	17611644	17611644	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctgcattcaagtcagatCtcggtgttctgctcaagact	9	10	6	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:17611644C>A	ENST00000381869.3	-	2	2146	c.1673G>T	c.(1672-1674)aGa>aTa	p.R558I	MTUS1_ENST00000519263.1_Missense_Mutation_p.R558I|MTUS1_ENST00000262102.6_Missense_Mutation_p.R558I|MTUS1_ENST00000381862.3_Missense_Mutation_p.R558I	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	558						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CAAGTCAGATCTCGGTGTTCT	0.428													62	136					1.88225e-35	2.70619e-35	1	1	0	A	17611644	C	A	17611644	3	1	48	1	0	0	0	0	1	0	0	0	10012	913	32	2	2514	2	MTUS1	8	17611644	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	104234	17611644	128752378	2033	6427										
SH2D4A	63898	broad.mit.edu	37	chr8	19250883	19250883	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgagcacaggcatgcccgGcagttttctcatccgagtca	10	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:19250883G>A	ENST00000265807.3	+	9	1514	c.1103G>A	c.(1102-1104)gGc>gAc	p.G368D	SH2D4A_ENST00000519207.1_Missense_Mutation_p.G368D|SH2D4A_ENST00000518040.1_Missense_Mutation_p.G323D	NM_001174160.1|NM_022071.3	NP_001167631.1|NP_071354.2	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	368	SH2.					cytoplasm|nucleus	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|stomach(1)	16				Colorectal(111;0.0732)		GGCATGCCCGGCAGTTTTCTC	0.473													5	88					0	0	1	0	0	A	19250883	G	A	19250883	3	1	48	1	0	0	0	0	1	0	0	0	14288	1203	42	3	1183	3	SH2D4A	8	19250883	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1639239	19250883	127113139	2034	6428										
INTS10	55174	broad.mit.edu	37	chr8	19684066	19684066	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgaaggaagagaaaaaaCcatggtaaggctttcaaata	10	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:19684066C>A	ENST00000397977.3	+	9	1534	c.1136C>A	c.(1135-1137)aCc>aAc	p.T379N		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	379					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		AGAGAAAAAACCATGGTAAGG	0.343													13	23					0.00136819	0.00143372	1	1	0	A	19684066	C	A	19684066	3	1	48	1	0	0	0	0	1	0	0	0	7819	507	18	5	1170	5	INTS10	8	19684066	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	433183	19684066	126679956	2035	6429										
INTS10	55174	broad.mit.edu	37	chr8	19709225	19709225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcgcctggccatggagcGccaggtctcccgctgtggag	14	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:19709225G>A	ENST00000397977.3	+	17	2440	c.2042G>A	c.(2041-2043)cGc>cAc	p.R681H		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	681					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		GCCATGGAGCGCCAGGTCTCC	0.537													27	60					0	0	1	0	0	A	19709225	G	A	19709225	3	1	48	1	0	0	0	0	1	0	0	0	7819	1087	38	1	2108	1	INTS10	8	19709225	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25159	19709225	126654797	2036	6430										
HR	55806	broad.mit.edu	37	chr8	21977295	21977295	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggctgcccagagctggggCtccagtggacgcagggcaag	17	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:21977295C>A	ENST00000381418.4	-	14	4435	c.2955G>T	c.(2953-2955)gaG>gaT	p.E985D	HR_ENST00000312841.8_Missense_Mutation_p.E985D	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	985	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		AGAGCTGGGGCTCCAGTGGAC	0.627													5	53					0.014758	0.015099	1	1	0	A	21977295	C	A	21977295	3	1	48	1	0	0	0	0	1	0	0	0	7387	796	28	5	638	5	HR	8	21977295	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2268070	21977295	124386727	2037	6431										
HR	55806	broad.mit.edu	37	chr8	21982828	21982828	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaggtcctgttcaccttcCcgctgggcccaagccagggc	13	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:21982828C>A	ENST00000381418.4	-	5	3226	c.1746G>T	c.(1744-1746)cgG>cgT	p.R582R	HR_ENST00000312841.8_Silent_p.R582R	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	582							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GTTCACCTTCCCGCTGGGCCC	0.687													5	6					0.000602214	0.000636035	1	1	0	A	21982828	C	A	21982828	2	1	48	1	0	0	0	0	0	0	0	1	7387	610	22	5		5	HR	8	21982828	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5533	21982828	124381194	2038	6432										
SFTPC	6440	broad.mit.edu	37	chr8	22019365	22019365	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgtgggcagcaaagaggtCctgatggagagcccgccggt	17	9	0	3	rs144603526	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:22019365C>T	ENST00000521315.1	+	1	56	c.24C>T	c.(22-24)gtC>gtT	p.V8V	SFTPC_ENST00000318561.3_Silent_p.V8V|SFTPC_ENST00000437090.2_Silent_p.V8V|SFTPC_ENST00000522109.1_Silent_p.V8V|SFTPC_ENST00000520605.1_Silent_p.V8V|SFTPC_ENST00000524255.1_Silent_p.V8V			P11686	PSPC_HUMAN	surfactant protein C	8					respiratory gaseous exchange	extracellular space				autonomic_ganglia(1)|large_intestine(1)|lung(1)	3				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GCAAAGAGGTCCTGATGGAGA	0.592													33	76					0	0	1	0	0	T	22019365	C	T	22019365	2	4	48	1	0	0	0	0	0	0	0	1	14245	842	30	3		3	SFTPC	8	22019365	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	36537	22019365	124344657	2039	6433										
TNFRSF10A	8797	broad.mit.edu	37	chr8	23049432	23049432	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaccagctctgaccacatcGatctcatttttcgtgaggtc	8	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:23049432G>A	ENST00000221132.3	-	10	1246	c.1182C>T	c.(1180-1182)atC>atT	p.I394I		NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	394	Death.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TGACCACATCGATCTCATTTT	0.527													37	71					0	0	1	0	0	A	23049432	G	A	23049432	2	1	48	1	0	0	0	0	0	0	0	1	16339	1048	37	1		1	TNFRSF10A	8	23049432	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1030067	23049432	123314590	2040	6434										
NEFL	4747	broad.mit.edu	37	chr8	24813109	24813109	+	RNA	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccttgagcagacgacggctCtcggacacctcgtccttggc	12	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:24813109C>T	ENST00000221169.5	-	0	1515							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GACGACGGCTCTCGGACACCT	0.622													21	34					0	0	1	0	0	T	24813109	C	T	24813109	1	4	48	0	1	0	0	0	0	0	0	0	10361	912	32	3		3	NEFL	8	24813109	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1763677	24813109	121550913	2041	6435										
EBF2	64641	broad.mit.edu	37	chr8	25897597	25897597	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatttccggattcttattCtgtccctcgtaagcgatggg	9	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:25897597C>A	ENST00000520164.1	-	5	966	c.429G>T	c.(427-429)caG>caT	p.Q143H	EBF2_ENST00000408929.3_5'UTR	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	143					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GATTCTTATTCTGTCCCTCGT	0.557													5	166					1	1	1	1	0	A	25897597	C	A	25897597	3	1	48	1	0	0	0	0	1	0	0	0	4907	912	32	2	1346	2	EBF2	8	25897597	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1084488	25897597	120466425	2042	6436										
PNMA2	10687	broad.mit.edu	37	chr8	26365965	26365965	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacaggttcaatctttcaaGaaactcagtgtcctgattag	7	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:26365965G>T	ENST00000522362.2	-	3	1201	c.307C>A	c.(307-309)Ctt>Att	p.L103I		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	103					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		aatctttcaagaaactcagtg	0.537													25	36					1.10923e-09	1.34134e-09	1	1	0	T	26365965	G	T	26365965	3	4	48	1	0	0	0	0	1	0	0	0	12201	942	33	2	791	2	PNMA2	8	26365965	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	468368	26365965	119998057	2043	6437										
HMBOX1	79618	broad.mit.edu	37	chr8	28866664	28866664	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaacagaagaaaagagcatTttaccgatggtatcaacttg	9	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:28866664T>G	ENST00000397358.3	+	6	1366	c.662T>G	c.(661-663)tTt>tGt	p.F221C	HMBOX1_ENST00000558662.1_Missense_Mutation_p.F221C|HMBOX1_ENST00000524238.1_Missense_Mutation_p.F221C|HMBOX1_ENST00000519047.1_Missense_Mutation_p.F221C|HMBOX1_ENST00000523613.1_Missense_Mutation_p.F221C|HMBOX1_ENST00000403668.2_Missense_Mutation_p.F221C|HMBOX1_ENST00000355231.5_Missense_Mutation_p.F221C|HMBOX1_ENST00000287701.10_Missense_Mutation_p.F221C|HMBOX1_ENST00000444075.1_Missense_Mutation_p.F221C	NM_024567.3	NP_078843.2	Q6NT76	HMBX1_HUMAN	homeobox containing 1	221					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	11		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		AAAAGAGCATTTTACCGATGG	0.373													20	32					0	0	1	0	0	G	28866664	T	G	28866664	3	3	48	1	0	0	0	0	1	0	0	0	7258	1841	64	4	676	4	HMBOX1	8	28866664	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2500699	28866664	117497358	2044	6438										
GTF2E2	2961	broad.mit.edu	37	chr8	30464620	30464620	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcattgaagaaaagtatTttcttcttatcgggacgatt	7	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:30464620T>G	ENST00000355904.4	-	6	879	c.597A>C	c.(595-597)aaA>aaC	p.K199N	GTF2E2_ENST00000522833.1_5'UTR	NM_002095.4	NP_002086.1	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2, beta 34kDa	199					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		AGAAAAGTATTTTCTTCTTAT	0.328													16	38					0	0	1	0	0	G	30464620	T	G	30464620	3	3	48	1	0	0	0	0	1	0	0	0	6897	1838	64	4	290	4	GTF2E2	8	30464620	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1597956	30464620	115899402	2045	6439										
TEX15	56154	broad.mit.edu	37	chr8	30695032	30695032	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttaatagatgaatttactAtatcattatcttgaagttca	4	4	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:30695032A>G	ENST00000256246.2	-	3	7693	c.7619T>C	c.(7618-7620)aTa>aCa	p.I2540T		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2540										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGAATTTACTATATCATTATC	0.368													10	29					0	0	1	0	0	G	30695032	A	G	30695032	3	3	48	1	0	0	0	0	1	0	0	0	15837	449	16	4	758	4	TEX15	8	30695032	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	230412	30695032	115668990	2046	6440										
TEX15	56154	broad.mit.edu	37	chr8	30701117	30701117	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaatggaacagaaagagaaAaatcaaagcaatcggaacaa	8	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:30701117A>C	ENST00000256246.2	-	1	5491	c.5417T>G	c.(5416-5418)tTt>tGt	p.F1806C		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1806										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGAAAGAGAAAAATCAAAGCA	0.323													19	33					0	0	1	0	0	C	30701117	A	C	30701117	3	2	48	1	0	0	0	0	1	0	0	0	15837	14	1	4	2968	4	TEX15	8	30701117	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6085	30701117	115662905	2047	6441										
TEX15	56154	broad.mit.edu	37	chr8	30701595	30701595	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttcaaaagcttccacaaAtaaagggagaatatttagac	6	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:30701595A>C	ENST00000256246.2	-	1	5013	c.4939T>G	c.(4939-4941)Ttt>Gtt	p.F1647V		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1647										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTTCCACAAATAAAGGGAGA	0.353													12	26					0	0	1	0	0	C	30701595	A	C	30701595	3	2	48	1	0	0	0	0	1	0	0	0	15837	101	4	4	3446	4	TEX15	8	30701595	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	478	30701595	115662427	2048	6442										
UNC5D	137970	broad.mit.edu	37	chr8	35583744	35583744	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catacagcggacccatctgtCtgcaggaccctctggacaag	10	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:35583744C>A	ENST00000287272.2	+	9	1191	c.1171C>A	c.(1171-1173)Ctg>Atg	p.L391M	UNC5D_ENST00000453357.2_Missense_Mutation_p.L455M|UNC5D_ENST00000420357.1_Missense_Mutation_p.L393M|UNC5D_ENST00000404895.2_Missense_Mutation_p.L460M|UNC5D_ENST00000449677.1_Missense_Mutation_p.L36M|UNC5D_ENST00000416672.1_Missense_Mutation_p.L465M			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	460					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACCCATCTGTCTGCAGGACCC	0.502													7	69					1.12685e-05	1.24509e-05	1	1	0	A	35583744	C	A	35583744	3	1	48	1	0	0	0	0	1	0	0	0	17054	912	32	2	1416	2	UNC5D	8	35583744	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4882149	35583744	110780278	2049	6443										
KCNU1	157855	broad.mit.edu	37	chr8	36671793	36671793	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatcatattttgagtcaatTtacctggtcatggcaacaac	6	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:36671793T>G	ENST00000399881.3	+	8	838	c.801T>G	c.(799-801)atT>atG	p.I267M		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	267						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TTGAGTCAATTTACCTGGTCA	0.433													12	18					0	0	1	0	0	G	36671793	T	G	36671793	3	3	48	1	0	0	0	0	1	0	0	0	8136	1829	64	4	831	4	KCNU1	8	36671793	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1088049	36671793	109692229	2050	6444										
DDHD2	23259	broad.mit.edu	37	chr8	38097797	38097797	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaatttcatttataggagaAcctttacaaatagatcactt	4	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:38097797A>G	ENST00000397166.2	+	6	1152	c.627A>G	c.(625-627)gaA>gaG	p.E209E	DDHD2_ENST00000520272.2_Silent_p.E209E	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	209					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TTATAGGAGAACCTTTACAAA	0.323													9	17					0	0	1	0	0	G	38097797	A	G	38097797	2	3	48	1	0	0	0	0	0	0	0	1	4350	40	2	4		4	DDHD2	8	38097797	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1426004	38097797	108266225	2051	6445										
LETM2	137994	broad.mit.edu	37	chr8	38257891	38257891	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaacagagccaagatgggCgatgcctctacacagctctc	11	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:38257891C>T	ENST00000379957.4	+	5	874	c.747C>T	c.(745-747)ggC>ggT	p.G249G	LETM2_ENST00000527710.1_Silent_p.G35G|LETM2_ENST00000297720.5_Silent_p.G154G|LETM2_ENST00000524874.1_Silent_p.G201G|LETM2_ENST00000523983.2_Silent_p.G202G	NM_001199659.1	NP_001186588.1	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane protein 2	249	LETM1.					integral to membrane|mitochondrial inner membrane				NS(1)|large_intestine(1)|lung(3)|prostate(2)	7	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			CCAAGATGGGCGATGCCTCTA	0.438													27	36					0	0	1	0	0	T	38257891	C	T	38257891	2	4	48	1	0	0	0	0	0	0	0	1	8773	755	27	1		1	LETM2	8	38257891	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	160094	38257891	108106131	2052	6446										
ADAM18	8749	broad.mit.edu	37	chr8	39537563	39537563	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccacttccagggatgttCtctgtggaaaattagcttgt	9	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:39537563C>A	ENST00000265707.5	+	16	1684	c.1639C>A	c.(1639-1641)Ctc>Atc	p.L547I	ADAM18_ENST00000379866.1_Missense_Mutation_p.L523I|ADAM18_ENST00000541111.1_5'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	547	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CAGGGATGTTCTCTGTGGAAA	0.338													9	13					1.12685e-05	1.24509e-05	1	1	0	A	39537563	C	A	39537563	3	1	48	1	0	0	0	0	1	0	0	0	238	913	32	2	1701	2	ADAM18	8	39537563	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1279672	39537563	106826459	2053	6447										
GOLGA7	51125	broad.mit.edu	37	chr8	41355133	41355133	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgaaggttgtttggcttgtTtaacagcatataccatcttc	8	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:41355133T>G	ENST00000357743.4	+	2	418	c.217T>G	c.(217-219)Tta>Gta	p.L73V	GOLGA7_ENST00000405786.2_Missense_Mutation_p.L73V|GOLGA7_ENST00000520817.1_Missense_Mutation_p.L73V|GOLGA7_ENST00000518270.1_Missense_Mutation_p.L73V	NM_001002296.1	NP_001002296.1	Q7Z5G4	GOGA7_HUMAN	golgin A7	73						Golgi membrane				breast(1)|large_intestine(1)	2	Ovarian(28;0.014)|Colorectal(14;0.0234)|Lung SC(25;0.211)	all_lung(54;0.000771)|Lung NSC(58;0.0031)|Hepatocellular(245;0.014)|Esophageal squamous(32;0.0559)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00596)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			TTTGGCTTGTTTAACAGCATA	0.388													46	79					0	0	1	0	0	G	41355133	T	G	41355133	3	3	48	1	0	0	0	0	1	0	0	0	6600	1838	64	4	223	4	GOLGA7	8	41355133	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1817570	41355133	105008889	2054	6448										
ANK1	286	broad.mit.edu	37	chr8	41530024	41530024	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcttagaacctggcagcttCtcttctgacctctgaccttc	6	15	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:41530024C>A	ENST00000396942.1	-	38	5027	c.4944G>T	c.(4942-4944)gaG>gaT	p.E1648D	ANK1_ENST00000265709.8_Missense_Mutation_p.E1689D|ANK1_ENST00000289734.7_Missense_Mutation_p.E1648D|ANK1_ENST00000352337.4_Missense_Mutation_p.E1648D|ANK1_ENST00000347528.4_Missense_Mutation_p.E1648D|ANK1_ENST00000396945.1_Missense_Mutation_p.E1648D|ANK1_ENST00000379758.2_Missense_Mutation_p.E1648D			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1648	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTGGCAGCTTCTCTTCTGACC	0.537													86	130					2.00703e-41	2.9019e-41	1	1	0	A	41530024	C	A	41530024	3	1	48	1	0	0	0	0	1	0	0	0	616	912	32	2	1047	2	ANK1	8	41530024	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	174891	41530024	104833998	2055	6449										
ANK1	286	broad.mit.edu	37	chr8	41753901	41753901	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcggtcacgggagcggtttCtccgcttcctgttggattcc	12	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:41753901C>A	ENST00000265709.8	-	1	379	c.98G>T	c.(97-99)aGa>aTa	p.R33I		NM_001142446.1	NP_001135918.1	P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	458	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGAGCGGTTTCTCCGCTTCCT	0.627													18	17					1.00905e-13	1.29777e-13	1	1	0	A	41753901	C	A	41753901	3	1	48	1	0	0	0	0	1	0	0	0	616	913	32	2	6199	2	ANK1	8	41753901	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	223877	41753901	104610121	2056	6450										
IKBKB	3551	broad.mit.edu	37	chr8	42173742	42173742	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacagtgtcctggctgagcGactggagaagtggctgcaac	14	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:42173742G>A	ENST00000520810.1	+	10	1001	c.815G>A	c.(814-816)cGa>cAa	p.R272Q	IKBKB_ENST00000379708.3_Missense_Mutation_p.R49Q|IKBKB_ENST00000520835.1_Missense_Mutation_p.R270Q|IKBKB_ENST00000416505.2_Missense_Mutation_p.R213Q|IKBKB_ENST00000522147.1_Intron	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	272	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	CTGGCTGAGCGACTGGAGAAG	0.587													18	34					0	0	1	0	0	A	42173742	G	A	42173742	3	1	48	1	0	0	0	0	1	0	0	0	7654	1058	37	1	849	1	IKBKB	8	42173742	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	419841	42173742	104190280	2057	6451										
SLC20A2	6575	broad.mit.edu	37	chr8	42329719	42329719	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggtttctcctactttggCgcctagtaacacggagccgg	11	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:42329719C>T	ENST00000342228.3	-	2	559	c.190G>A	c.(190-192)Gcc>Acc	p.A64T	SLC20A2_ENST00000520262.1_Missense_Mutation_p.A64T|SLC20A2_ENST00000520179.1_Missense_Mutation_p.A64T	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	64					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CCTACTTTGGCGCCTAGTAAC	0.512													90	180					0	0	1	0	0	T	42329719	C	T	42329719	3	4	48	1	0	0	0	0	1	0	0	0	14493	768	27	1	1808	1	SLC20A2	8	42329719	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	155977	42329719	104034303	2058	6452										
CHRNA6	8973	broad.mit.edu	37	chr8	42611406	42611406	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgatggacagtgtgacaaaGatcatggtgaacagcaggta	13	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:42611406G>T	ENST00000276410.2	-	5	1291	c.936C>A	c.(934-936)atC>atA	p.I312I	CHRNA6_ENST00000534622.1_Silent_p.I297I	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	312						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GTGTGACAAAGATCATGGTGA	0.507													26	48					4.47668e-21	6.17272e-21	1	1	0	T	42611406	G	T	42611406	2	4	48	1	0	0	0	0	0	0	0	1	3409	932	33	2		2	CHRNA6	8	42611406	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	281687	42611406	103752616	2059	6453										
RNF170	81790	broad.mit.edu	37	chr8	42711377	42711377	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaataaaaagatgacaaaGaaatcatctagaaagcctag	7	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:42711377G>T	ENST00000534961.1	-	7	1178	c.702C>A	c.(700-702)ttC>ttA	p.F234L	RNF170_ENST00000527424.1_Missense_Mutation_p.F234L|RNF170_ENST00000319104.3_Intron|RNF170_ENST00000526349.1_Missense_Mutation_p.F150L|RNF170_ENST00000319073.4_Missense_Mutation_p.F138L	NM_001160223.1	NP_001153695.1	Q96K19	RN170_HUMAN	ring finger protein 170	234						integral to membrane	zinc ion binding			lung(3)	3	all_lung(13;1.25e-11)|Lung NSC(13;3.55e-10)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00645)|Lung NSC(58;0.0176)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			AGATGACAAAGAAATCATCTA	0.318													26	39					2.79863e-10	3.42475e-10	1	1	0	T	42711377	G	T	42711377	3	4	48	1	0	0	0	0	1	0	0	0	13513	933	33	2	289	2	RNF170	8	42711377	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	99971	42711377	103652645	2060	6454										
HGSNAT	138050	broad.mit.edu	37	chr8	43047473	43047473	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttggtcctgggggcattgGagattttggcaagtatccaa	13	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:43047473G>T	ENST00000458501.2	+	13	1361	c.1361G>T	c.(1360-1362)gGa>gTa	p.G454V	HGSNAT_ENST00000379644.4_Missense_Mutation_p.G426V|HGSNAT_ENST00000521576.1_Missense_Mutation_p.G143V|HGSNAT_ENST00000297798.7_Missense_Mutation_p.G158V			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	454					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GGGGGCATTGGAGATTTTGGC	0.483													3	16					0.115264	0.116507	1	1	0	T	43047473	G	T	43047473	3	4	48	1	0	0	0	0	1	0	0	0	7128	1174	41	2	1327	2	HGSNAT	8	43047473	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	336096	43047473	103316549	2061	6455										
PXDNL	137902	broad.mit.edu	37	chr8	52287292	52287292	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacctggagagccgtacaacCtggaacagagacaggcagac	12	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:52287292C>T	ENST00000356297.4	-	18	3658		c.e18-1		PXDNL_ENST00000543296.1_Splice_Site	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like						hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCCGTACAACCTGGAACAGAG	0.468													12	18					0	0	1	0	0	T	52287292	C	T	52287292	5	4	48	1	0	0	0	0	0	0	1	0	12899	695	24	3	858	3	PXDNL	8	52287292	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9239819	52287292	94076730	2062	6456										
PXDNL	137902	broad.mit.edu	37	chr8	52469436	52469436	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagtcctttaaatgtttgcTtatctagtgcatggatttca	8	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:52469436T>G	ENST00000356297.4	-	4	444	c.344A>C	c.(343-345)aAg>aCg	p.K115T	PXDNL_ENST00000543296.1_Missense_Mutation_p.K115T	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	115					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AAATGTTTGCTTATCTAGTGC	0.284													15	24					0	0	1	0	0	G	52469436	T	G	52469436	3	3	48	1	0	0	0	0	1	0	0	0	12899	1609	56	4	4127	4	PXDNL	8	52469436	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	182144	52469436	93894586	2063	6457										
PCMTD1	115294	broad.mit.edu	37	chr8	52773557	52773557	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgcttccaggctaagtctTtgtaagcattgtctctgtag	9	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:52773557T>G	ENST00000360540.5	-	3	561	c.155A>C	c.(154-156)aAa>aCa	p.K52T	PCMTD1_ENST00000522514.1_Missense_Mutation_p.K52T|PCMTD1_ENST00000521344.1_Missense_Mutation_p.K52T|PCMTD1_ENST00000544451.1_Intron|PCMTD1_ENST00000519559.1_Intron	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	52						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				GGCTAAGTCTTTGTAAGCATT	0.408													18	38					0	0	1	0	0	G	52773557	T	G	52773557	3	3	48	1	0	0	0	0	1	0	0	0	11632	1841	64	4	938	4	PCMTD1	8	52773557	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	304121	52773557	93590465	2064	6458										
RGS20	8601	broad.mit.edu	37	chr8	54791868	54791868	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccgccgccccgaagctgttCggcctcctttctagcccgct	9	20	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:54791868C>T	ENST00000297313.3	+	2	308	c.216C>T	c.(214-216)ttC>ttT	p.F72F	RGS20_ENST00000344277.6_Intron	NM_170587.2	NP_733466.1	O76081	RGS20_HUMAN	regulator of G-protein signaling 20	72					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			breast(2)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			CGAAGCTGTTCGGCCTCCTTT	0.647													68	158					0	0	1	0	0	T	54791868	C	T	54791868	2	4	48	1	0	0	0	0	0	0	0	1	13352	883	31	1		1	RGS20	8	54791868	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2018311	54791868	91572154	2065	6459										
RP1	6101	broad.mit.edu	37	chr8	55541124	55541124	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggagaaactaagatggtaaAaatgatggtgaaaactatgg	12	2	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:55541124A>C	ENST00000220676.1	+	4	4830	c.4682A>C	c.(4681-4683)aAa>aCa	p.K1561T		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1561					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGATGGTAAAAATGATGGTG	0.363													17	17					0	0	1	0	0	C	55541124	A	C	55541124	3	2	48	1	0	0	0	0	1	0	0	0	13583	14	1	4	4692	4	RP1	8	55541124	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	749256	55541124	90822898	2066	6460										
RP1	6101	broad.mit.edu	37	chr8	55541339	55541339	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttgttaaaagggcaataGaaaaactgtacggtaaagca	10	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:55541339G>T	ENST00000220676.1	+	4	5045	c.4897G>T	c.(4897-4899)Gaa>Taa	p.E1633*		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1633					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGGCAATAGAAAAACTGTA	0.383													29	62					1.68575e-08	1.99097e-08	1	1	0	T	55541339	G	T	55541339	4	4	48	1	0	0	0	0	0	1	0	0	13583	943	33	2	4907	2	RP1	8	55541339	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	215	55541339	90822683	2067	6461										
RP1	6101	broad.mit.edu	37	chr8	55542167	55542167	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaagctgactctttggatAaactgtatgctctttgtggt	11	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:55542167A>G	ENST00000220676.1	+	4	5873	c.5725A>G	c.(5725-5727)Aaa>Gaa	p.K1909E		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1909					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CTCTTTGGATAAACTGTATGC	0.398													29	40					0	0	1	0	0	G	55542167	A	G	55542167	3	3	48	1	0	0	0	0	1	0	0	0	13583	363	13	4	5735	4	RP1	8	55542167	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	828	55542167	90821855	2068	6462										
TMEM68	137695	broad.mit.edu	37	chr8	56668917	56668917	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatagctccatgataaaaaaTtataagtgctggtccatctt	6	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:56668917T>G	ENST00000434581.2	-	4	578	c.379A>C	c.(379-381)Att>Ctt	p.I127L	TMEM68_ENST00000523073.1_Missense_Mutation_p.I13L|TMEM68_ENST00000334667.2_Missense_Mutation_p.I127L|TMEM68_ENST00000519784.1_Missense_Mutation_p.I13L			Q96MH6	TMM68_HUMAN	transmembrane protein 68	127						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			TGATAAAAAATTATAAGTGCT	0.303													12	29					0	0	1	0	0	G	56668917	T	G	56668917	3	3	48	1	0	0	0	0	1	0	0	0	16256	1493	52	4	406	4	TMEM68	8	56668917	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1126750	56668917	89695105	2069	6463										
LYN	4067	broad.mit.edu	37	chr8	56882318	56882318	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcgatgaaggtggcaaagTgctgcttccaaagctcattg	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:56882318T>C	ENST00000520220.2	+	10	1227	c.953T>C	c.(952-954)gTg>gCg	p.V318A	LYN_ENST00000519728.1_Missense_Mutation_p.V339A|LYN_ENST00000420292.1_3'UTR	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	339	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GGTGGCAAAGTGCTGCTTCCA	0.428													21	52					0	0	1	0	0	C	56882318	T	C	56882318	3	2	48	1	0	0	0	0	1	0	0	0	9152	1696	59	4	1050	4	LYN	8	56882318	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	213401	56882318	89481704	2070	6464										
LYN	4067	broad.mit.edu	37	chr8	56922551	56922551	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcccagatgagctctatgAcattatgaaaatgtgctgga	10	8	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:56922551A>C	ENST00000520220.2	+	13	1632	c.1358A>C	c.(1357-1359)gAc>gCc	p.D453A	LYN_ENST00000519728.1_Missense_Mutation_p.D474A	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	474	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GAGCTCTATGACATTATGAAA	0.502													18	74					0	0	1	0	0	C	56922551	A	C	56922551	3	2	48	1	0	0	0	0	1	0	0	0	9152	275	10	4	1467	4	LYN	8	56922551	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	40233	56922551	89441471	2071	6465										
CYP7A1	1581	broad.mit.edu	37	chr8	59409553	59409553	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatcactcggtagcagaaaGaatacatcccttctgtcacc	6	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:59409553G>T	ENST00000301645.3	-	3	655	c.518C>A	c.(517-519)tCt>tAt	p.S173Y		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	173					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GTAGCAGAAAGAATACATCCC	0.453									Neonatal Giant Cell Hepatitis				32	101					3.67414e-24	5.15076e-24	1	1	0	T	59409553	G	T	59409553	3	4	48	1	0	0	0	0	1	0	0	0	4219	942	33	2	1012	2	CYP7A1	8	59409553	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2487002	59409553	86954469	2072	6466										
TOX	9760	broad.mit.edu	37	chr8	59764207	59764207	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcccatattcaaaccaagtTgagcacttagctgtgactgg	8	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:59764207T>C	ENST00000361421.1	-	4	789	c.569A>G	c.(568-570)cAa>cGa	p.Q190R		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	190						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CAAACCAAGTTGAGCACTTAG	0.522													13	27					0	0	1	0	0	C	59764207	T	C	59764207	3	2	48	1	0	0	0	0	1	0	0	0	16437	1812	63	4	1035	4	TOX	8	59764207	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	354654	59764207	86599815	2073	6467										
CA8	767	broad.mit.edu	37	chr8	61193682	61193682	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcggggaaggcgacggtatCttcgatgaagctcaggtccg	15	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:61193682C>A	ENST00000317995.4	-	1	289	c.25G>T	c.(25-27)Gat>Tat	p.D9Y		NM_004056.4	NP_004047.3	P35219	CAH8_HUMAN	carbonic anhydrase VIII	9					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(6)|prostate(2)|skin(1)	16		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				GCGACGGTATCTTCGATGAAG	0.677													6	10					0.217242	0.218251	1	1	0	A	61193682	C	A	61193682	3	1	48	1	0	0	0	0	1	0	0	0	2541	913	32	2	879	2	CA8	8	61193682	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1429475	61193682	85170340	2074	6468										
YTHDF3	253943	broad.mit.edu	37	chr8	64099024	64099024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacacaaagttctgcttataGtagcagttatggctatccac	7	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:64099024G>A	ENST00000539294.1	+	4	768	c.452G>A	c.(451-453)aGt>aAt	p.S151N	YTHDF3_ENST00000517371.1_Intron|YTHDF3_ENST00000521674.1_3'UTR|YTHDF3_ENST00000542911.2_5'UTR	NM_001277817.1|NM_001277818.1|NM_152758.4	NP_001264746.1|NP_001264747.1|NP_689971.4	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	152												Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			TCTGCTTATAGTAGCAGTTAT	0.433													10	26					0	0	1	0	0	A	64099024	G	A	64099024	3	1	48	1	0	0	0	0	1	0	0	0	17559	1029	36	3	468	3	YTHDF3	8	64099024	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2905342	64099024	82264998	2075	6469										
TRIM55	84675	broad.mit.edu	37	chr8	67047346	67047346	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtgtttggtgcacacaaaGactgccaggtggctcccctc	12	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:67047346G>T	ENST00000315962.4	+	3	836	c.463G>T	c.(463-465)Gac>Tac	p.D155Y	TRIM55_ENST00000350034.4_Missense_Mutation_p.D155Y|TRIM55_ENST00000353317.5_Missense_Mutation_p.D155Y|TRIM55_ENST00000276573.7_Missense_Mutation_p.D155Y	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	155						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			TGCACACAAAGACTGCCAGGT	0.572													36	82					3.33393e-15	4.38315e-15	1	1	0	T	67047346	G	T	67047346	3	4	48	1	0	0	0	0	1	0	0	0	16589	942	33	2	473	2	TRIM55	8	67047346	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2948322	67047346	79316676	2076	6470										
TRIM55	84675	broad.mit.edu	37	chr8	67064644	67064644	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaagaagaagaaggcggaGaaggagaaaaagaaggagaa	16	1	0	8			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:67064644G>T	ENST00000315962.4	+	8	1391	c.1018G>T	c.(1018-1020)Gaa>Taa	p.E340*	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000353317.5_Nonsense_Mutation_p.E340*|TRIM55_ENST00000276573.7_Nonsense_Mutation_p.E340*	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	340						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			agaaggcggagaaggagaaaa	0.418													9	11					0.000274275	0.000292037	1	1	0	T	67064644	G	T	67064644	4	4	48	1	0	0	0	0	0	1	0	0	16589	943	33	2	1048	2	TRIM55	8	67064644	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17298	67064644	79299378	2077	6471										
MYBL1	4603	broad.mit.edu	37	chr8	67488572	67488572	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagaagcagcagcatcagaAatatcaaaactggtaacgtc	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:67488572A>C	ENST00000522677.3	-	10	1550	c.1140T>G	c.(1138-1140)atT>atG	p.I380M	MYBL1_ENST00000517885.1_Intron|MYBL1_ENST00000524176.2_Missense_Mutation_p.I380M	NM_001080416.2|NM_001144755.1	NP_001073885.1|NP_001138227.1	P10243	MYBA_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 1	380	Negative regulatory domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|skin(1)	25			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			CAGCATCAGAAATATCAAAAC	0.378													59	92					0	0	1	0	0	C	67488572	A	C	67488572	3	2	48	1	0	0	0	0	1	0	0	0	10056	10	1	4	1146	4	MYBL1	8	67488572	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	423928	67488572	78875450	2078	6472										
SGK3	23678	broad.mit.edu	37	chr8	67710856	67710856	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtttgataaactttataAcactgtaagtaatcgtctac	6	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:67710856A>C	ENST00000396596.1	+	3	390	c.176A>C	c.(175-177)aAc>aCc	p.N59T	SGK3_ENST00000345714.4_Missense_Mutation_p.N59T|SGK3_ENST00000520976.1_Missense_Mutation_p.N59T|SGK3_ENST00000522398.1_Missense_Mutation_p.N59T|SGK3_ENST00000521198.2_Missense_Mutation_p.N59T|C8orf44-SGK3_ENST00000519289.1_Missense_Mutation_p.N59T	NM_013257.4	NP_037389.4	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase family, member 3	59	PX.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	18	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AAACTTTATAACACTGTAAGT	0.308													46	61					0	0	1	0	0	C	67710856	A	C	67710856	3	2	48	1	0	0	0	0	1	0	0	0	14265	43	2	4	182	4	SGK3	8	67710856	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	222284	67710856	78653166	2079	6473										
ARFGEF1	10565	broad.mit.edu	37	chr8	68111283	68111283	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttcaggaatcaagtcaaaTtgcataatttcacataagag	7	6	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:68111283T>C	ENST00000262215.3	-	39	5825	c.5436A>G	c.(5434-5436)caA>caG	p.Q1812Q	ARFGEF1_ENST00000520381.1_Intron|ARFGEF1_ENST00000517955.1_5'UTR	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1812					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCAAGTCAAATTGCATAATTT	0.383													23	55					0	0	1	0	0	C	68111283	T	C	68111283	2	2	48	1	0	0	0	0	0	0	0	1	849	1490	52	4		4	ARFGEF1	8	68111283	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	400427	68111283	78252739	2080	6474										
ARFGEF1	10565	broad.mit.edu	37	chr8	68183948	68183948	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaacgtacctcaatttgcaTcttcagatgtgtcttgaaat	6	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:68183948T>C	ENST00000262215.3	-	10	1950	c.1561A>G	c.(1561-1563)Atg>Gtg	p.M521V		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	521					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCAATTTGCATCTTCAGATGT	0.318													10	24					0	0	1	0	0	C	68183948	T	C	68183948	3	2	48	1	0	0	0	0	1	0	0	0	849	1435	50	4	4108	4	ARFGEF1	8	68183948	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	72665	68183948	78180074	2081	6475										
SULF1	23213	broad.mit.edu	37	chr8	70512901	70512901	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attatgcagtacacaggaccAatgctgcccatccacatgga	8	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:70512901A>G	ENST00000260128.4	+	9	1515	c.798A>G	c.(796-798)ccA>ccG	p.P266P	SULF1_ENST00000458141.2_Silent_p.P266P|SULF1_ENST00000419716.3_Silent_p.P266P|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Silent_p.P266P	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	266					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ACACAGGACCAATGCTGCCCA	0.393													43	59					0	0	1	0	0	G	70512901	A	G	70512901	2	3	48	1	0	0	0	0	0	0	0	1	15425	117	5	4		4	SULF1	8	70512901	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2328953	70512901	75851121	2082	6476										
SULF1	23213	broad.mit.edu	37	chr8	70515435	70515435	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccctttacagagtcccacAgatcgttctcaacattgact	6	14	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:70515435A>C	ENST00000260128.4	+	11	1787	c.1070A>C	c.(1069-1071)cAg>cCg	p.Q357P	SULF1_ENST00000458141.2_Missense_Mutation_p.Q357P|SULF1_ENST00000419716.3_Missense_Mutation_p.Q357P|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Missense_Mutation_p.Q357P	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	357					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AGAGTCCCACAGATCGTTCTC	0.542													68	139					0	0	1	0	0	C	70515435	A	C	70515435	3	2	48	1	0	0	0	0	1	0	0	0	15425	188	7	4	1096	4	SULF1	8	70515435	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2534	70515435	75848587	2083	6477										
TRAM1	23471	broad.mit.edu	37	chr8	71495556	71495556	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaatggatgccagaacagcGattctaagaaatattaagac	8	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:71495556G>T	ENST00000521425.1	-	10	1672	c.636C>A	c.(634-636)atC>atA	p.I212I	TRAM1_ENST00000262213.2_Silent_p.I298I|TRAM1_ENST00000536748.1_Silent_p.I267I			Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	298	TLC.				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	17			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			CCAGAACAGCGATTCTAAGAA	0.348													8	16					0.000274275	0.000292037	1	1	0	T	71495556	G	T	71495556	2	4	48	1	0	0	0	0	0	0	0	1	16511	1048	37	2		2	TRAM1	8	71495556	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	980121	71495556	74868466	2084	6478										
JPH1	56704	broad.mit.edu	37	chr8	75156775	75156775	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtacttactgaattggcttCtttttccaaagcagggcatg	9	8	1	1	rs75912309		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:75156775C>A	ENST00000342232.4	-	4	1934	c.1894G>T	c.(1894-1896)Gaa>Taa	p.E632*	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	632					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GAATTGGCTTCTTTTTCCAAA	0.433													35	82					3.6622e-26	5.17531e-26	1	1	0	A	75156775	C	A	75156775	4	1	48	1	0	0	0	0	0	1	0	0	8003	922	32	2	99	2	JPH1	8	75156775	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3661219	75156775	71207247	2085	6479										
TPD52	7163	broad.mit.edu	37	chr8	80992558	80992558	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attagtagttaccaaatttcTgaagagtaggtgatccgggt	11	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:80992558T>C	ENST00000520527.1	-	1	493	c.131A>G	c.(130-132)cAg>cGg	p.Q44R	TPD52_ENST00000448733.2_Missense_Mutation_p.Q44R|TPD52_ENST00000379097.3_Missense_Mutation_p.Q44R|TPD52_ENST00000518937.1_Intron|TPD52_ENST00000517427.1_Missense_Mutation_p.Q44R|TPD52_ENST00000379096.5_Intron|TPD52_ENST00000537855.1_Missense_Mutation_p.Q44R|TPD52_ENST00000519303.2_Intron			P55327	TPD52_HUMAN	tumor protein D52	44					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			ACCAAATTTCTGAAGAGTAGG	0.383													13	20					0	0	1	0	0	C	80992558	T	C	80992558	3	2	48	1	0	0	0	0	1	0	0	0	16457	1580	55	4	644	4	TPD52	8	80992558	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5835783	80992558	65371464	2086	6480										
ZBTB10	65986	broad.mit.edu	37	chr8	81431737	81431737	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcgatgggatgaatcaggaGaagtttgtatgtctctagat	12	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:81431737G>T	ENST00000430430.1	+	7	3369	c.2590G>T	c.(2590-2592)Gaa>Taa	p.E864*	ZBTB10_ENST00000379091.4_Nonsense_Mutation_p.E572*|ZBTB10_ENST00000455036.3_Nonsense_Mutation_p.E864*|ZBTB10_ENST00000426744.2_Nonsense_Mutation_p.E840*	NM_001277145.1	NP_001264074.1	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10	864					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(4)	20	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			TGAATCAGGAGAAGTTTGTAT	0.403													8	11					0.000442599	0.00046913	1	1	0	T	81431737	G	T	81431737	4	4	48	1	0	0	0	0	0	1	0	0	17581	943	33	2	2612	2	ZBTB10	8	81431737	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	439179	81431737	64932285	2087	6481										
FABP9	646480	broad.mit.edu	37	chr8	82373692	82373692	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggtatttctcacccagttCtttcatgtaatcctcaaagt	5	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:82373692C>A	ENST00000379071.2	-	1	122	c.67G>T	c.(67-69)Gaa>Taa	p.E23*	RP11-157I4.4_ENST00000524085.2_RNA	NM_001080526.1	NP_001073995.1	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	23							lipid binding|transporter activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6			Epithelial(68;0.186)			TCACCCAGTTCTTTCATGTAA	0.398													9	121					0.000274275	0.000292037	1	1	0	A	82373692	C	A	82373692	4	1	48	1	0	0	0	0	0	1	0	0	5394	922	32	2	346	2	FABP9	8	82373692	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	941955	82373692	63990330	2088	6482										
RALYL	138046	broad.mit.edu	37	chr8	85774639	85774639	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggggaaaggagtcttttcCatgaaaggtggatcgagatc	15	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:85774639C>T	ENST00000521268.1	+	6	1627	c.522C>T	c.(520-522)tcC>tcT	p.S174S	RALYL_ENST00000522455.1_Silent_p.S174S|RALYL_ENST00000523850.1_Silent_p.S101S|RALYL_ENST00000518566.1_Silent_p.S163S|RALYL_ENST00000517638.1_Silent_p.S187S|RALYL_ENST00000521376.1_Silent_p.S85S|RALYL_ENST00000521695.1_Silent_p.S174S	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	174							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						GAGTCTTTTCCATGAAAGGTG	0.483													13	21					0	0	1	0	0	T	85774639	C	T	85774639	2	4	48	1	0	0	0	0	0	0	0	1	13071	581	21	3		3	RALYL	8	85774639	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3400947	85774639	60589383	2089	6483										
LRRCC1	85444	broad.mit.edu	37	chr8	86021859	86021859	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attatctttagattcaactcTtcatgccgtcaatcttcatt	3	10	7	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:86021859T>A	ENST00000414626.2	+	1	963	c.74T>A	c.(73-75)cTt>cAt	p.L25H	LRRCC1_ENST00000360375.3_Missense_Mutation_p.L45H			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	45					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						GATTCAACTCTTCATGCCGTC	0.274													6	11					0	0	1	0	0	A	86021859	T	A	86021859	3	1	48	1	0	0	0	0	1	0	0	0	9070	1609	56	4	140	4	LRRCC1	8	86021859	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	247220	86021859	60342163	2090	6484										
LRRCC1	85444	broad.mit.edu	37	chr8	86027431	86027431	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatttgacagaaataaattCatcacagctgcagtgcctag	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:86027431C>A	ENST00000414626.2	+	4	1470	c.581C>A	c.(580-582)tCa>tAa	p.S194*	LRRCC1_ENST00000360375.3_Nonsense_Mutation_p.S214*			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	214	LRRCT.				cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						GAAATAAATTCATCACAGCTG	0.353													16	35					0.000566183	0.00059967	1	1	0	A	86027431	C	A	86027431	4	1	48	1	0	0	0	0	0	1	0	0	9070	838	29	2	659	2	LRRCC1	8	86027431	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5572	86027431	60336591	2091	6485										
ATP6V0D2	245972	broad.mit.edu	37	chr8	87155104	87155104	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgatcttttttctttttaAgtcttaccttgaggcattct	5	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:87155104A>C	ENST00000285393.3	+	5	703		c.e5-1		CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						TTTCTTTTTAAGTCTTACCTT	0.303													21	53					0	0	1	0	0	C	87155104	A	C	87155104	5	2	48	1	0	0	0	0	0	0	1	0	1172	86	3	4	578	4	ATP6V0D2	8	87155104	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1127673	87155104	59208918	2092	6486										
WWP1	11059	broad.mit.edu	37	chr8	87393822	87393822	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattaggaaaagcaacgataGatttgaaacaagctctgttg	9	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:87393822G>A	ENST00000517970.1	+	5	605	c.298G>A	c.(298-300)Gat>Aat	p.D100N	WWP1_ENST00000523863.1_3'UTR|WWP1_ENST00000265428.4_Missense_Mutation_p.D100N|WWP1_ENST00000341922.2_Missense_Mutation_p.D100N|WWP1_ENST00000349423.2_Intron	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	100					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AGCAACGATAGATTTGAAACA	0.333													22	34					0	0	1	0	0	A	87393822	G	A	87393822	3	1	48	1	0	0	0	0	1	0	0	0	17474	942	33	3	308	3	WWP1	8	87393822	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	238718	87393822	58970200	2093	6487										
WWP1	11059	broad.mit.edu	37	chr8	87460450	87460450	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgtatgttaagtaaaaaacTtactattaaggatttggaat	8	3	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:87460450T>G	ENST00000517970.1	+	19	2379	c.2072T>G	c.(2071-2073)cTt>cGt	p.L691R	WWP1_ENST00000265428.4_Missense_Mutation_p.L691R|WWP1_ENST00000341922.2_Missense_Mutation_p.L561R|WWP1_ENST00000349423.2_Missense_Mutation_p.L473R	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	691	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AGTAAAAAACTTACTATTAAG	0.274													4	21					0	0	1	0	0	G	87460450	T	G	87460450	3	3	48	1	0	0	0	0	1	0	0	0	17474	1609	56	4	2138	4	WWP1	8	87460450	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	66628	87460450	58903572	2094	6488										
CNGB3	54714	broad.mit.edu	37	chr8	87588271	87588271	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attttcttttcctttatcttCattttctttttgtttatctt	1	7	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:87588271C>A	ENST00000320005.5	-	18	2238	c.2191G>T	c.(2191-2193)Gaa>Taa	p.E731*		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	731					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						cctttatcttcattttctttt	0.353													13	26					2.27111e-07	2.60515e-07	1	1	0	A	87588271	C	A	87588271	4	1	48	1	0	0	0	0	0	1	0	0	3624	835	29	2	242	2	CNGB3	8	87588271	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	127821	87588271	58775751	2095	6489										
CNGB3	54714	broad.mit.edu	37	chr8	87656060	87656060	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaataaacacaggcattaAtgtgcagaataaacagcaag	8	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:87656060A>C	ENST00000320005.5	-	10	1144	c.1097T>G	c.(1096-1098)aTt>aGt	p.I366S		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	366					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						ACAGGCATTAATGTGCAGAAT	0.368													25	39					0	0	1	0	0	C	87656060	A	C	87656060	3	2	48	1	0	0	0	0	1	0	0	0	3624	101	4	4	1368	4	CNGB3	8	87656060	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	67789	87656060	58707962	2096	6490										
CNGB3	54714	broad.mit.edu	37	chr8	87680283	87680283	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgtttggaagtttaattcGctttaagtactctgttaaag	9	5	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:87680283G>A	ENST00000320005.5	-	5	654	c.607C>T	c.(607-609)Cga>Tga	p.R203*		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	203			R -> Q (in ACHM3; uncertain pathogenicity; dbSNP:rs16916632).		signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AGTTTAATTCGCTTTAAGTAC	0.398													45	82					0	0	1	0	0	A	87680283	G	A	87680283	4	1	48	1	0	0	0	0	0	1	0	0	3624	1095	38	1	1878	1	CNGB3	8	87680283	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24223	87680283	58683739	2097	6491										
CNBD1	168975	broad.mit.edu	37	chr8	88249206	88249206	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagctcgacctcaaacaaacGtgtataaaaatctgattgaa	6	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:88249206G>T	ENST00000518476.1	+	6	688	c.637G>T	c.(637-639)Gtg>Ttg	p.V213L	CNBD1_ENST00000522427.1_3'UTR	NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	213										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TCAAACAAACGTGTATAAAAA	0.363													18	49					1.33834e-09	1.61283e-09	1	1	0	T	88249206	G	T	88249206	3	4	48	1	0	0	0	0	1	0	0	0	3614	1145	40	5	659	5	CNBD1	8	88249206	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	568923	88249206	58114816	2098	6492										
CNBD1	168975	broad.mit.edu	37	chr8	88365879	88365879	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacagaaaagatctcaaaaaCttgtttatatggggaaactt	7	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:88365879C>A	ENST00000518476.1	+	10	1219	c.1168C>A	c.(1168-1170)Ctt>Att	p.L390I		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	390										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						ATCTCAAAAACTTGTTTATAT	0.318													19	21					2.4624e-09	2.95225e-09	1	1	0	A	88365879	C	A	88365879	3	1	48	1	0	0	0	0	1	0	0	0	3614	565	20	5	1206	5	CNBD1	8	88365879	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	116673	88365879	57998143	2099	6493										
TMEM55A	55529	broad.mit.edu	37	chr8	92008023	92008023	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacataggttgctcgaaatCgccttgcaaaatctggggtg	11	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:92008023C>T	ENST00000285419.3	-	7	970	c.656G>A	c.(655-657)cGa>cAa	p.R219Q		NM_018710.2	NP_061180.1	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	219						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	13			BRCA - Breast invasive adenocarcinoma(11;0.033)			TGCTCGAAATCGCCTTGCAAA	0.373													8	47					0	0	1	0	0	T	92008023	C	T	92008023	3	4	48	1	0	0	0	0	1	0	0	0	16240	884	31	1	121	1	TMEM55A	8	92008023	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3642144	92008023	54355999	2100	6494										
OTUD6B	51633	broad.mit.edu	37	chr8	92082634	92082634	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaggcggtattgaccgaaGagcttgatgaggaagagcag	17	5	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:92082634G>T	ENST00000285420.4	+	1	211	c.112G>T	c.(112-114)Gag>Tag	p.E38*	OTUD6B_ENST00000404789.3_5'UTR	NM_016023.3	NP_057107.3	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	8										endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11			BRCA - Breast invasive adenocarcinoma(11;0.0187)			ATTGACCGAAGAGCTTGATGA	0.582													9	14					0.0477658	0.0484551	1	1	0	T	92082634	G	T	92082634	4	4	48	1	0	0	0	0	0	1	0	0	11363	943	33	2	114	2	OTUD6B	8	92082634	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	74611	92082634	54281388	2101	6495										
OTUD6B	51633	broad.mit.edu	37	chr8	92083511	92083511	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaagctgactactaaggaGaataaggtatgtgaaataaa	10	3	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:92083511G>T	ENST00000285420.4	+	2	417	c.318G>T	c.(316-318)gaG>gaT	p.E106D	OTUD6B_ENST00000404789.3_5'UTR	NM_016023.3	NP_057107.3	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	76										endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11			BRCA - Breast invasive adenocarcinoma(11;0.0187)			CTACTAAGGAGAATAAGGTAT	0.373													28	56					1.68575e-08	1.99097e-08	1	1	0	T	92083511	G	T	92083511	3	4	48	1	0	0	0	0	1	0	0	0	11363	933	33	2	324	2	OTUD6B	8	92083511	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	877	92083511	54280511	2102	6496										
OTUD6B	51633	broad.mit.edu	37	chr8	92090712	92090712	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggcagctagacagttagaAattaaacagattccatctga	8	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:92090712A>C	ENST00000285420.4	+	4	633	c.534A>C	c.(532-534)gaA>gaC	p.E178D	OTUD6B_ENST00000404789.3_Missense_Mutation_p.E47D	NM_016023.3	NP_057107.3	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	148	OTU.									endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11			BRCA - Breast invasive adenocarcinoma(11;0.0187)			GACAGTTAGAAATTAAACAGA	0.398													11	14					0	0	1	0	0	C	92090712	A	C	92090712	3	2	48	1	0	0	0	0	1	0	0	0	11363	11	1	4	548	4	OTUD6B	8	92090712	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7201	92090712	54273310	2103	6497										
TMEM67	91147	broad.mit.edu	37	chr8	94792860	94792860	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgtcaagctcttggaaatAtgtgtgtgatgaacatgaat	10	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:94792860A>G	ENST00000453321.3	+	8	812	c.754A>G	c.(754-756)Atg>Gtg	p.M252V	TMEM67_ENST00000425545.2_3'UTR|TMEM67_ENST00000409623.3_Missense_Mutation_p.M171V	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	252			M -> T (in MKS3 and COACHS; also in a patient with overlaping clinical features with JBTS6).		cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			TCTTGGAAATATGTGTGTGAT	0.368													41	81					0	0	1	0	0	G	94792860	A	G	94792860	3	3	48	1	0	0	0	0	1	0	0	0	16255	449	16	4	922	4	TMEM67	8	94792860	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2702148	94792860	51571162	2104	6498										
CDH17	1015	broad.mit.edu	37	chr8	95164299	95164299	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctcaggattttctgctttGaacacaatgttggaaacagc	10	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:95164299G>T	ENST00000027335.3	-	13	1717	c.1593C>A	c.(1591-1593)ttC>ttA	p.F531L	CDH17_ENST00000441892.2_Missense_Mutation_p.F317L|CDH17_ENST00000450165.2_Missense_Mutation_p.F531L	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	531	Cadherin 5.					integral to membrane	calcium ion binding	p.F531F(1)		NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTTCTGCTTTGAACACAATGT	0.398													18	31					1.56452e-12	1.97515e-12	1	1	0	T	95164299	G	T	95164299	3	4	48	1	0	0	0	0	1	0	0	0	3124	1281	45	2	929	2	CDH17	8	95164299	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	371439	95164299	51199723	2105	6499										
KIAA1429	25962	broad.mit.edu	37	chr8	95539304	95539304	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctatcttctctatacaaatCtaagagttctgttaacttca	3	9	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:95539304C>A	ENST00000297591.5	-	8	1243	c.1168G>T	c.(1168-1170)Gat>Tat	p.D390Y	KIAA1429_ENST00000421249.2_Missense_Mutation_p.D390Y|KIAA1429_ENST00000437199.1_Missense_Mutation_p.D390Y	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	390					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTATACAAATCTAAGAGTTCT	0.338													34	69					4.65686e-17	6.22576e-17	1	1	0	A	95539304	C	A	95539304	3	1	48	1	0	0	0	0	1	0	0	0	8272	913	32	2	4392	2	KIAA1429	8	95539304	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	375005	95539304	50824718	2106	6500										
DPY19L4	286148	broad.mit.edu	37	chr8	95800138	95800138	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagatctaccaaatctattCaaagcgatctgctgaggata	7	9	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:95800138C>A	ENST00000414645.2	+	18	1964	c.1865C>A	c.(1864-1866)tCa>tAa	p.S622*		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	622						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					CAAATCTATTCAAAGCGATCT	0.279													8	27					1.76689e-08	2.08373e-08	1	1	0	A	95800138	C	A	95800138	4	1	48	1	0	0	0	0	0	1	0	0	4769	838	29	2	1935	2	DPY19L4	8	95800138	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	260834	95800138	50563884	2107	6501										
INTS8	55656	broad.mit.edu	37	chr8	95837290	95837290	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggacttagacatattagaGaaaaggtatccaagatttca	9	5	1	3	rs141032302	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:95837290G>T	ENST00000523731.1	+	2	433	c.300G>T	c.(298-300)gaG>gaT	p.E100D	INTS8_ENST00000447247.1_Missense_Mutation_p.E100D	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	100					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					ACATATTAGAGAAAAGGTATC	0.318													13	30					0.000151284	0.00016287	1	1	0	T	95837290	G	T	95837290	3	4	48	1	0	0	0	0	1	0	0	0	7827	933	33	2	306	2	INTS8	8	95837290	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37152	95837290	50526732	2108	6502										
INTS8	55656	broad.mit.edu	37	chr8	95884164	95884164	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacagtgaaagagctagttCgatatacactcagtataaat	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:95884164C>T	ENST00000523731.1	+	21	2600	c.2467C>T	c.(2467-2469)Cga>Tga	p.R823*	INTS8_ENST00000447247.1_Nonsense_Mutation_p.R823*	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	823					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					AGAGCTAGTTCGATATACACT	0.348													16	30					0	0	1	0	0	T	95884164	C	T	95884164	4	4	48	1	0	0	0	0	0	1	0	0	7827	876	31	1	2549	1	INTS8	8	95884164	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	46874	95884164	50479858	2109	6503										
TSPYL5	85453	broad.mit.edu	37	chr8	98288981	98288981	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgttgattatctccacaatCttgtcagactcaatggagct	7	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:98288981C>A	ENST00000322128.3	-	1	1195	c.1092G>T	c.(1090-1092)aaG>aaT	p.K364N		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	364					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					TCTCCACAATCTTGTCAGACT	0.468													60	118					1.16596e-39	1.68366e-39	1	1	0	A	98288981	C	A	98288981	3	1	48	1	0	0	0	0	1	0	0	0	16722	912	32	2	165	2	TSPYL5	8	98288981	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2404817	98288981	48075041	2110	6504										
TSPYL5	85453	broad.mit.edu	37	chr8	98289208	98289208	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgattttgtagcccaatcTggcaaggccgagctcttcca	9	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:98289208T>G	ENST00000322128.3	-	1	968	c.865A>C	c.(865-867)Aga>Cga	p.R289R		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	289					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					TAGCCCAATCTGGCAAGGCCG	0.468													10	57					0	0	1	0	0	G	98289208	T	G	98289208	2	3	48	1	0	0	0	0	0	0	0	1	16722	1588	55	4		4	TSPYL5	8	98289208	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	227	98289208	48074814	2111	6505										
POP1	10940	broad.mit.edu	37	chr8	99139912	99139912	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatgagcagtcttcctccAaagggatgtttagaaaaaag	10	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:99139912A>G	ENST00000401707.2	+	3	313	c.232A>G	c.(232-234)Aaa>Gaa	p.K78E	POP1_ENST00000349693.3_Missense_Mutation_p.K78E	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	78					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GTCTTCCTCCAAAGGGATGTT	0.498													28	51					0	0	1	0	0	G	99139912	A	G	99139912	3	3	48	1	0	0	0	0	1	0	0	0	12298	131	5	4	238	4	POP1	8	99139912	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	850704	99139912	47224110	2112	6506										
POP1	10940	broad.mit.edu	37	chr8	99142362	99142362	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgccaagcggtttcatatgGtcaagaagtggggctactgc	13	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:99142362G>A	ENST00000401707.2	+	5	724	c.643G>A	c.(643-645)Gtc>Atc	p.V215I	POP1_ENST00000349693.3_Missense_Mutation_p.V215I	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	215					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GTTTCATATGGTCAAGAAGTG	0.512													31	56					0	0	1	0	0	A	99142362	G	A	99142362	3	1	48	1	0	0	0	0	1	0	0	0	12298	1261	44	3	657	3	POP1	8	99142362	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2450	99142362	47221660	2113	6507										
KCNS2	3788	broad.mit.edu	37	chr8	99440676	99440676	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatccttgccttctacaacGacgcctccaagttcgatggg	9	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:99440676G>T	ENST00000287042.4	+	2	819	c.469G>T	c.(469-471)Gac>Tac	p.D157Y	KCNS2_ENST00000521839.1_Missense_Mutation_p.D157Y	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	157						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CTTCTACAACGACGCCTCCAA	0.612													31	34					2.49675e-24	3.5028e-24	1	1	0	T	99440676	G	T	99440676	3	4	48	1	0	0	0	0	1	0	0	0	8132	1058	37	2	471	2	KCNS2	8	99440676	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	298314	99440676	46923346	2114	6508										
VPS13B	157680	broad.mit.edu	37	chr8	100523395	100523395	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctctctctgacatacacaAaagctgtaacaaaaaatgtc	4	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:100523395A>G	ENST00000358544.2	+	29	4474	c.4363A>G	c.(4363-4365)Aaa>Gaa	p.K1455E	VPS13B_ENST00000357162.2_Missense_Mutation_p.K1430E|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1455					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GACATACACAAAAGCTGTAAC	0.378													22	42					0	0	1	0	0	G	100523395	A	G	100523395	3	3	48	1	0	0	0	0	1	0	0	0	17249	15	1	4	4667	4	VPS13B	8	100523395	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1082719	100523395	45840627	2115	6509										
VPS13B	157680	broad.mit.edu	37	chr8	100568703	100568703	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttgaacttaggaattcttCgagatcctggatcagaaatc	8	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:100568703C>T	ENST00000358544.2	+	31	4957	c.4846C>T	c.(4846-4848)Cga>Tga	p.R1616*	VPS13B_ENST00000357162.2_Nonsense_Mutation_p.R1591*|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1616					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGGAATTCTTCGAGATCCTGG	0.358													15	15					0	0	1	0	0	T	100568703	C	T	100568703	4	4	48	1	0	0	0	0	0	1	0	0	17249	876	31	1	5158	1	VPS13B	8	100568703	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	45308	100568703	45795319	2116	6510										
VPS13B	157680	broad.mit.edu	37	chr8	100568745	100568745	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagacagacaataccaaataGatctgcagtccatcaatatt	5	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:100568745G>T	ENST00000358544.2	+	31	4999	c.4888G>T	c.(4888-4890)Gat>Tat	p.D1630Y	VPS13B_ENST00000357162.2_Missense_Mutation_p.D1605Y|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1630					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATACCAAATAGATCTGCAGTC	0.408													14	22					1.3612e-06	1.53357e-06	1	1	0	T	100568745	G	T	100568745	3	4	48	1	0	0	0	0	1	0	0	0	17249	942	33	2	5200	2	VPS13B	8	100568745	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42	100568745	45795277	2117	6511										
VPS13B	157680	broad.mit.edu	37	chr8	100779084	100779084	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatctgtctgaaagcaaagTttgtgaactgcagttgccgg	11	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:100779084T>G	ENST00000358544.2	+	40	7319	c.7208T>G	c.(7207-7209)gTt>gGt	p.V2403G	VPS13B_ENST00000357162.2_Missense_Mutation_p.V2378G|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2403					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GAAAGCAAAGTTTGTGAACTG	0.358													16	29					0	0	1	0	0	G	100779084	T	G	100779084	3	3	48	1	0	0	0	0	1	0	0	0	17249	1725	60	4	7556	4	VPS13B	8	100779084	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	210339	100779084	45584938	2118	6512										
RGS22	26166	broad.mit.edu	37	chr8	101084433	101084433	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctttcttttttgatccacTtaataccttcttcacgactg	4	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:101084433T>G	ENST00000360863.6	-	5	559	c.365A>C	c.(364-366)aAg>aCg	p.K122T	RGS22_ENST00000523437.1_Missense_Mutation_p.K122T|RGS22_ENST00000523287.1_Intron	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	122					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTTGATCCACTTAATACCTTC	0.318													7	39					0	0	1	0	0	G	101084433	T	G	101084433	3	3	48	1	0	0	0	0	1	0	0	0	13354	1609	56	4	3521	4	RGS22	8	101084433	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	305349	101084433	45279589	2119	6513										
RGS22	26166	broad.mit.edu	37	chr8	101117607	101117607	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaatgatacttacaaattCttcttctgtaatagttggtg	7	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:101117607C>A	ENST00000360863.6	-	2	243	c.49G>T	c.(49-51)Gaa>Taa	p.E17*	RGS22_ENST00000523437.1_Nonsense_Mutation_p.E17*|RGS22_ENST00000523287.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	17					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity	p.E17*(2)	RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CTTACAAATTCTTCTTCTGTA	0.328													19	26					1.15919e-05	1.28007e-05	1	1	0	A	101117607	C	A	101117607	4	1	48	1	0	0	0	0	0	1	0	0	13354	922	32	2	3849	2	RGS22	8	101117607	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	33174	101117607	45246415	2120	6514										
UBR5	51366	broad.mit.edu	37	chr8	103298680	103298680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcattgaacggggagcttggGcagcaccattggcatgggag	17	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:103298680G>A	ENST00000520539.1	-	38	5729	c.5123C>T	c.(5122-5124)gCc>gTc	p.A1708V	UBR5_ENST00000521922.1_Missense_Mutation_p.A1702V|UBR5_ENST00000220959.4_Missense_Mutation_p.A1708V	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1708					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GGGAGCTTGGGCAGCACCATT	0.522													31	35					0	0	1	0	0	A	103298680	G	A	103298680	3	1	48	1	0	0	0	0	1	0	0	0	16965	1203	42	3	3364	3	UBR5	8	103298680	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2181073	103298680	43065342	2121	6515										
ODF1	4956	broad.mit.edu	37	chr8	103572979	103572979	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttgctacccttgcacttCtccttgcagcccctgcagcc	6	19	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:103572979C>T	ENST00000285402.3	+	2	776	c.620C>T	c.(619-621)tCt>tTt	p.S207F	ODF1_ENST00000518835.1_Intron	NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	207					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CCTTGCACTTCTCCTtgcagc	0.587													25	33					0	0	1	0	0	T	103572979	C	T	103572979	3	4	48	1	0	0	0	0	1	0	0	0	10873	913	32	3	626	3	ODF1	8	103572979	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	274299	103572979	42791043	2122	6516										
ATP6V1C1	528	broad.mit.edu	37	chr8	104065041	104065041	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatcttcagaatttggaacGaaagaatgcgtaagcagatc	9	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:104065041G>A	ENST00000395862.3	+	6	623	c.464G>A	c.(463-465)cGa>cAa	p.R155Q	ATP6V1C1_ENST00000518738.1_Missense_Mutation_p.R155Q|ATP6V1C1_ENST00000518857.1_Missense_Mutation_p.R80Q|ATP6V1C1_ENST00000521514.1_Missense_Mutation_p.R80Q	NM_001695.4	NP_001686.1	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	155					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			AATTTGGAACGAAAGAATGCG	0.368													17	33					0	0	1	0	0	A	104065041	G	A	104065041	3	1	48	1	0	0	0	0	1	0	0	0	1178	1058	37	1	482	1	ATP6V1C1	8	104065041	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	492062	104065041	42298981	2123	6517										
RIMS2	9699	broad.mit.edu	37	chr8	104924348	104924348	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgcattttattaaataagcGtctaaaagatggaagtgtac	8	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:104924348G>A	ENST00000507740.1	+	4	1420	c.1184G>A	c.(1183-1185)cGt>cAt	p.R395H	RIMS2_ENST00000436393.2_Missense_Mutation_p.R365H|RIMS2_ENST00000262231.10_Missense_Mutation_p.R442H|RIMS2_ENST00000406091.3_Missense_Mutation_p.R587H	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	665					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.R395H(1)|p.R670H(1)|p.R365H(1)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTAAATAAGCGTCTAAAAGAT	0.353										HNSCC(12;0.0054)			21	52					0	0	1	0	0	A	104924348	G	A	104924348	3	1	48	1	0	0	0	0	1	0	0	0	13419	1145	40	1	1908	1	RIMS2	8	104924348	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	859307	104924348	41439674	2124	6518										
LRP12	29967	broad.mit.edu	37	chr8	105509413	105509413	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacgattgtttttacaatggAaatttcctggttggcaaaaa	8	5	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:105509413A>G	ENST00000276654.5	-	5	1475	c.1367T>C	c.(1366-1368)tTc>tCc	p.F456S	LRP12_ENST00000424843.2_Missense_Mutation_p.F437S	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	456	LDL-receptor class A 5.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTTACAATGGAAATTTCCTGG	0.413													32	53					0	0	1	0	0	G	105509413	A	G	105509413	3	3	48	1	0	0	0	0	1	0	0	0	8998	246	9	4	1224	4	LRP12	8	105509413	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	585065	105509413	40854609	2125	6519										
ZFPM2	23414	broad.mit.edu	37	chr8	106811074	106811074	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccggtgtcagaggaaaatGaagacagtgcccatcagatt	11	9	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:106811074G>T	ENST00000407775.2	+	7	1112	c.862G>T	c.(862-864)Gaa>Taa	p.E288*	ZFPM2_ENST00000378472.4_Nonsense_Mutation_p.E19*|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000517361.1_Nonsense_Mutation_p.E156*|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000520492.1_Nonsense_Mutation_p.E156*|RP11-152P17.2_ENST00000520433.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	288					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGAGGAAAATGAAGACAGTGC	0.517													36	88					2.40579e-17	3.22781e-17	1	1	0	T	106811074	G	T	106811074	4	4	48	1	0	0	0	0	0	1	0	0	17715	1291	45	2	888	2	ZFPM2	8	106811074	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1301661	106811074	39552948	2126	6520										
OXR1	55074	broad.mit.edu	37	chr8	107691480	107691480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacaagaaagatggaagacGaatgtcttttcagaaaccta	9	6	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:107691480G>A	ENST00000445937.1	+	4	524	c.263G>A	c.(262-264)cGa>cAa	p.R88Q	OXR1_ENST00000312046.6_Missense_Mutation_p.R81Q|OXR1_ENST00000452423.2_5'UTR|OXR1_ENST00000517566.2_Missense_Mutation_p.R88Q|OXR1_ENST00000531443.1_Missense_Mutation_p.R88Q|OXR1_ENST00000442977.2_Missense_Mutation_p.R89Q|OXR1_ENST00000497705.1_Missense_Mutation_p.R21Q	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	89					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion		p.R89Q(1)		NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			GATGGAAGACGAATGTCTTTT	0.338													11	42					0	0	1	0	0	A	107691480	G	A	107691480	3	1	48	1	0	0	0	0	1	0	0	0	11380	1058	37	1	476	1	OXR1	8	107691480	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	880406	107691480	38672542	2127	6521										
OXR1	55074	broad.mit.edu	37	chr8	107705011	107705011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctactttcactggtattcGacctgcacgagttgtatctt	7	10	3	0	rs149485264		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:107705011G>A	ENST00000445937.1	+	7	842	c.581G>A	c.(580-582)cGa>cAa	p.R194Q	OXR1_ENST00000312046.6_Missense_Mutation_p.R187Q|OXR1_ENST00000452423.2_5'UTR|OXR1_ENST00000517566.2_Missense_Mutation_p.R194Q|OXR1_ENST00000531443.1_Missense_Mutation_p.R194Q|OXR1_ENST00000442977.2_Missense_Mutation_p.R195Q|OXR1_ENST00000497705.1_Missense_Mutation_p.R127Q	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	195					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion		p.R106Q(1)|p.R195Q(1)		NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			ACTGGTATTCGACCTGCACGA	0.343													14	23					0	0	1	0	0	A	107705011	G	A	107705011	3	1	48	1	0	0	0	0	1	0	0	0	11380	1058	37	1	806	1	OXR1	8	107705011	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13531	107705011	38659011	2128	6522										
OXR1	55074	broad.mit.edu	37	chr8	107722985	107722985	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatgcacagagagataagaAacatgaatattggtttgctg	11	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:107722985A>C	ENST00000445937.1	+	10	2021	c.1760A>C	c.(1759-1761)aAa>aCa	p.K587T	OXR1_ENST00000312046.6_Missense_Mutation_p.K580T|OXR1_ENST00000452423.2_Missense_Mutation_p.K77T|OXR1_ENST00000517566.2_Missense_Mutation_p.K587T|OXR1_ENST00000531443.1_Missense_Mutation_p.K587T|OXR1_ENST00000442977.2_Missense_Mutation_p.K588T	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	588					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			AGAGATAAGAAACATGAATAT	0.358													13	30					0	0	1	0	0	C	107722985	A	C	107722985	3	2	48	1	0	0	0	0	1	0	0	0	11380	14	1	4	1997	4	OXR1	8	107722985	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	17974	107722985	38641037	2129	6523										
ABRA	137735	broad.mit.edu	37	chr8	107773289	107773289	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgagtagcgtaatcacaacAtggtcatctcggccttgcca	9	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:107773289A>C	ENST00000311955.3	-	2	1176	c.1122T>G	c.(1120-1122)caT>caG	p.H374Q		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	374	Interaction with actin (By similarity).				positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TAATCACAACATGGTCATCTC	0.418													50	84					0	0	1	0	0	C	107773289	A	C	107773289	3	2	48	1	0	0	0	0	1	0	0	0	100	214	8	4	27	4	ABRA	8	107773289	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	50304	107773289	38590733	2130	6524										
TRHR	7201	broad.mit.edu	37	chr8	110099941	110099941	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaactgctacctggtgagccTggcagtagctgatctcatgg	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:110099941T>C	ENST00000518632.1	+	2	551	c.200T>C	c.(199-201)cTg>cCg	p.L67P	TRHR_ENST00000311762.2_Missense_Mutation_p.L67P			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	67						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CTGGTGAGCCTGGCAGTAGCT	0.527													27	63					0	0	1	0	0	C	110099941	T	C	110099941	3	2	48	1	0	0	0	0	1	0	0	0	16540	1580	55	4	202	4	TRHR	8	110099941	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2326652	110099941	36264081	2131	6525										
PKHD1L1	93035	broad.mit.edu	37	chr8	110420308	110420308	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgcttggttatgaagtagTtgaagggaataatgtcacac	11	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:110420308T>C	ENST00000378402.5	+	18	1948	c.1844T>C	c.(1843-1845)gTt>gCt	p.V615A		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	615					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATGAAGTAGTTGAAGGGAAT	0.343										HNSCC(38;0.096)			13	27					0	0	1	0	0	C	110420308	T	C	110420308	3	2	48	1	0	0	0	0	1	0	0	0	12019	1725	60	4	1914	4	PKHD1L1	8	110420308	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	320367	110420308	35943714	2132	6526										
PKHD1L1	93035	broad.mit.edu	37	chr8	110504169	110504169	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcactttcggtttggccaggAacctatcagaacagaaaaga	10	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:110504169A>G	ENST00000378402.5	+	62	10286	c.10182A>G	c.(10180-10182)ggA>ggG	p.G3394G		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3394					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTGGCCAGGAACCTATCAGA	0.348										HNSCC(38;0.096)			7	9					0	0	1	0	0	G	110504169	A	G	110504169	2	3	48	1	0	0	0	0	0	0	0	1	12019	233	9	4		4	PKHD1L1	8	110504169	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	83861	110504169	35859853	2133	6527										
CSMD3	114788	broad.mit.edu	37	chr8	113246683	113246683	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatatgcgtaacattaggcGagcttcctggcttttatata	8	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:113246683G>A	ENST00000297405.5	-	68	10895	c.10651C>T	c.(10651-10653)Cgc>Tgc	p.R3551C	CSMD3_ENST00000343508.3_Missense_Mutation_p.R3511C|CSMD3_ENST00000455883.2_Missense_Mutation_p.R3382C|CSMD3_ENST00000352409.3_Missense_Mutation_p.R3481C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3551						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AACATTAGGCGAGCTTCCTGG	0.328										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	63					0	0	1	0	0	A	113246683	G	A	113246683	3	1	48	1	0	0	0	0	1	0	0	0	3971	1058	37	1	488	1	CSMD3	8	113246683	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2742514	113246683	33117339	2134	6528										
CSMD3	114788	broad.mit.edu	37	chr8	113316973	113316973	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcaatatggtctttcatttCtccaactccaagtaccatta	5	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:113316973C>A	ENST00000297405.5	-	52	8487	c.8243G>T	c.(8242-8244)aGa>aTa	p.R2748I	CSMD3_ENST00000343508.3_Missense_Mutation_p.R2708I|CSMD3_ENST00000455883.2_Intron|CSMD3_ENST00000352409.3_Missense_Mutation_p.R2678I	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2748	Sushi 16.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTTTCATTTCTCCAACTCCA	0.368										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	25					1.01871e-10	1.25646e-10	1	1	0	A	113316973	C	A	113316973	3	1	48	1	0	0	0	0	1	0	0	0	3971	913	32	2	2960	2	CSMD3	8	113316973	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	70290	113316973	33047049	2135	6529										
CSMD3	114788	broad.mit.edu	37	chr8	113529438	113529438	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggacccctgggtcacgacaCgcagtggcaacagaacctat	12	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:113529438C>T	ENST00000297405.5	-	28	4825	c.4581G>A	c.(4579-4581)gcG>gcA	p.A1527A	CSMD3_ENST00000343508.3_Silent_p.A1487A|CSMD3_ENST00000455883.2_Silent_p.A1423A|CSMD3_ENST00000352409.3_Silent_p.A1527A	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1527	Sushi 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGTCACGACACGCAGTGGCAA	0.403										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	18					0	0	1	0	0	T	113529438	C	T	113529438	2	4	48	1	0	0	0	0	0	0	0	1	3971	523	19	1		1	CSMD3	8	113529438	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	212465	113529438	32834584	2136	6530										
CSMD3	114788	broad.mit.edu	37	chr8	113960026	113960026	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaaaatattacctaaaatCtgatccgattctcttcccat	2	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:113960026C>A	ENST00000297405.5	-	9	1745	c.1501G>T	c.(1501-1503)Gat>Tat	p.D501Y	CSMD3_ENST00000343508.3_Missense_Mutation_p.D461Y|CSMD3_ENST00000455883.2_Missense_Mutation_p.D397Y|CSMD3_ENST00000352409.3_Missense_Mutation_p.D501Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	501	Sushi 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TACCTAAAATCTGATCCGATT	0.303										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	8					0.00909568	0.00935351	1	1	0	A	113960026	C	A	113960026	3	1	48	1	0	0	0	0	1	0	0	0	3971	913	32	2	9874	2	CSMD3	8	113960026	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	430588	113960026	32403996	2137	6531										
TNFRSF11B	4982	broad.mit.edu	37	chr8	119941087	119941087	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactgcaatttgtgtgttttCtacagggtgctttagatgac	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:119941087C>T	ENST00000297350.4	-	3	860	c.482G>A	c.(481-483)aGa>aAa	p.R161K		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	161					apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			TGTGTGTTTTCTACAGGGTGC	0.413													32	50					0	0	1	0	0	T	119941087	C	T	119941087	3	4	48	1	0	0	0	0	1	0	0	0	16344	913	32	3	735	3	TNFRSF11B	8	119941087	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5981061	119941087	26422935	2138	6532										
COLEC10	10584	broad.mit.edu	37	chr8	120079578	120079578	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcctcctggtactatttCttttgcaaattcagagtctg	6	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:120079578C>A	ENST00000332843.2	+	1	99	c.58C>A	c.(58-60)Ctt>Att	p.L20I	COLEC10_ENST00000521788.1_Intron|RP11-278I4.2_ENST00000518362.1_RNA	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	20						collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			GGTACTATTTCTTTTGCAAAT	0.453													16	32					3.45872e-05	3.78815e-05	1	1	0	A	120079578	C	A	120079578	3	1	48	1	0	0	0	0	1	0	0	0	3733	913	32	2	60	2	COLEC10	8	120079578	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	138491	120079578	26284444	2139	6533										
COL14A1	7373	broad.mit.edu	37	chr8	121243839	121243839	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagctcaaggggaccctgaGgaagaagtcataggaacggt	14	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:121243839G>T	ENST00000297848.3	+	19	2601	c.2331G>T	c.(2329-2331)gaG>gaT	p.E777D	COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.E777D|COL14A1_ENST00000247781.3_Missense_Mutation_p.E682D|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	777	Fibronectin type-III 6.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGGACCCTGAGGAAGAAGTCA	0.443													9	24					3.09899e-07	3.54467e-07	1	1	0	T	121243839	G	T	121243839	3	4	48	1	0	0	0	0	1	0	0	0	3694	991	35	5	2401	5	COL14A1	8	121243839	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1164261	121243839	25120183	2140	6534										
MTBP	27085	broad.mit.edu	37	chr8	121528236	121528236	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttcagtctcgtcttattcGttatgaaactcaaactacct	4	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:121528236G>A	ENST00000305949.1	+	18	2096	c.2051G>A	c.(2050-2052)cGt>cAt	p.R684H		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	684	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			CGTCTTATTCGTTATGAAACT	0.408													20	44					0	0	1	0	0	A	121528236	G	A	121528236	3	1	48	1	0	0	0	0	1	0	0	0	9959	1145	40	1	2121	1	MTBP	8	121528236	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	284397	121528236	24835786	2141	6535										
HAS2	3037	broad.mit.edu	37	chr8	122641078	122641078	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaattgcgttacgtgttgcGagctttctttatgtgactca	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:122641078G>A	ENST00000303924.4	-	2	1040	c.503C>T	c.(502-504)tCg>tTg	p.S168L		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	168						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TACGTGTTGCGAGCTTTCTTT	0.448													59	124					0	0	1	0	0	A	122641078	G	A	122641078	3	1	48	1	0	0	0	0	1	0	0	0	7002	1059	37	1	1167	1	HAS2	8	122641078	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1112842	122641078	23722944	2142	6536										
C8orf76	84933	broad.mit.edu	37	chr8	124243893	124243893	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatgcaaagaaatcagtttCtgcaggcagaaaattgtttt	10	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:124243893C>A	ENST00000276704.4	-	4	513	c.462G>T	c.(460-462)caG>caT	p.Q154H	C8orf76_ENST00000521310.1_5'UTR|ZHX1-C8ORF76_ENST00000357082.4_Missense_Mutation_p.Q122H	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	154							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AAATCAGTTTCTGCAGGCAGA	0.443													44	86					2.24893e-16	2.99237e-16	1	1	0	A	124243893	C	A	124243893	3	1	48	1	0	0	0	0	1	0	0	0	2455	912	32	2	692	2	C8orf76	8	124243893	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1602815	124243893	22120129	2143	6537										
ATAD2	29028	broad.mit.edu	37	chr8	124358483	124358483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctactatcaatattcttggtCgaaaagacataggttggtaa	8	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:124358483C>T	ENST00000287394.5	-	18	2482	c.2375G>A	c.(2374-2376)cGa>cAa	p.R792Q	ATAD2_ENST00000521903.1_Missense_Mutation_p.R110Q	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	792					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TATTCTTGGTCGAAAAGACAT	0.343													16	43					0	0	1	0	0	T	124358483	C	T	124358483	3	4	48	1	0	0	0	0	1	0	0	0	1070	884	31	1	1841	1	ATAD2	8	124358483	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	114590	124358483	22005539	2144	6538										
KLHL38	340359	broad.mit.edu	37	chr8	124663962	124663962	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcagatgctgtcataccttTccatggagcccatgagctcc	9	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:124663962T>G	ENST00000325995.7	-	1	1228	c.1205A>C	c.(1204-1206)gAa>gCa	p.E402A	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	402										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						GTCATACCTTTCCATGGAGCC	0.567													8	59					0	0	1	0	0	G	124663962	T	G	124663962	3	3	48	1	0	0	0	0	1	0	0	0	8432	1783	62	4	552	4	KLHL38	8	124663962	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	305479	124663962	21700060	2145	6539										
ANXA13	312	broad.mit.edu	37	chr8	124701112	124701112	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcctaactttactttaccGagagttaaataggccttctg	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:124701112G>A	ENST00000262219.6	-	10	907	c.841_splice	c.e10+1	p.L280_splice	ANXA13_ENST00000419625.1_Splice_Site_p.L239_splice	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13	239					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			TTACTTTACCGAGAGTTAAAT	0.443													23	38					0	0	1	0	0	A	124701112	G	A	124701112	5	1	48	1	0	0	0	0	0	0	1	0	711	1072	37	1	245	1	ANXA13	8	124701112	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37150	124701112	21662910	2146	6540										
FER1L6	654463	broad.mit.edu	37	chr8	125088538	125088538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaccgggataaatacatcCctaaacaactgaacccagta	6	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:125088538C>T	ENST00000522917.1	+	32	4398	c.4192C>T	c.(4192-4194)Cct>Tct	p.P1398S	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.P1398S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1398	C2 5.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TAAATACATCCCTAAACAACT	0.443													68	116					0	0	1	0	0	T	125088538	C	T	125088538	3	4	48	1	0	0	0	0	1	0	0	0	5847	623	22	3	4314	3	FER1L6	8	125088538	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	387426	125088538	21275484	2147	6541										
FER1L6	654463	broad.mit.edu	37	chr8	125131132	125131132	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttacagcagaagaagctgaGaaaaatcctgttggaaaagc	11	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:125131132G>T	ENST00000522917.1	+	40	5543	c.5337G>T	c.(5335-5337)gaG>gaT	p.E1779D	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.E1779D	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1779						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGAAGCTGAGAAAAATCCTG	0.498													11	31					6.40141e-05	6.95424e-05	1	1	0	T	125131132	G	T	125131132	3	4	48	1	0	0	0	0	1	0	0	0	5847	933	33	2	5491	2	FER1L6	8	125131132	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42594	125131132	21232890	2148	6542										
RNF139	11236	broad.mit.edu	37	chr8	125499514	125499514	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaagggagccgcttacaaGaaataaatgatgtatgtgca	10	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:125499514G>T	ENST00000303545.3	+	2	1996	c.1624G>T	c.(1624-1626)Gaa>Taa	p.E542*		NM_007218.3	NP_009149.2	Q8WU17	RN139_HUMAN	ring finger protein 139	542					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(1)	20	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CCGCTTACAAGAAATAAATGA	0.373													14	36					1.52009e-12	1.92208e-12	1	1	0	T	125499514	G	T	125499514	4	4	48	1	0	0	0	0	0	1	0	0	13493	943	33	2	1630	2	RNF139	8	125499514	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	368382	125499514	20864508	2149	6543										
KIAA0196	9897	broad.mit.edu	37	chr8	126056266	126056266	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaggggactgacagcattcAtgagggtttttaaagtgtcc	12	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:126056266A>G	ENST00000318410.7	-	22	3087	c.2738T>C	c.(2737-2739)aTg>aCg	p.M913T	KIAA0196-AS1_ENST00000519140.1_RNA|KIAA0196_ENST00000517845.1_Missense_Mutation_p.M765T	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	913					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GACAGCATTCATGAGGGTTTT	0.413													12	31					0	0	1	0	0	G	126056266	A	G	126056266	3	3	48	1	0	0	0	0	1	0	0	0	8202	217	8	4	773	4	KIAA0196	8	126056266	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	556752	126056266	20307756	2150	6544										
NSMCE2	286053	broad.mit.edu	37	chr8	126194402	126194402	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattattggtagagaagaaaTttttggctttacagagcaag	10	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:126194402T>A	ENST00000287437.3	+	5	538	c.322T>A	c.(322-324)Ttt>Att	p.F108I	NSMCE2_ENST00000522563.1_Missense_Mutation_p.F108I|NSMCE2_ENST00000517315.1_Missense_Mutation_p.F48I	NM_173685.2	NP_775956.1	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog (S. cerevisiae)	108				F -> L (in Ref. 1; BAB71338).	DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	9	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			AGAGAAGAAATTTTTGGCTTT	0.294													4	72					0	0	1	0	0	A	126194402	T	A	126194402	3	1	48	1	0	0	0	0	1	0	0	0	10723	1493	52	4	332	4	NSMCE2	8	126194402	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	138136	126194402	20169620	2151	6545										
GSDMC	56169	broad.mit.edu	37	chr8	130772804	130772804	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactcaccatcttgaaaggtTctctgttcatcatcatctga	5	11	7	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:130772804T>G	ENST00000276708.4	-	6	1589	c.708A>C	c.(706-708)agA>agC	p.R236S		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	236						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CTTGAAAGGTTCTCTGTTCAT	0.373													8	62					0	0	1	0	0	G	130772804	T	G	130772804	3	3	48	1	0	0	0	0	1	0	0	0	6858	1780	62	4	854	4	GSDMC	8	130772804	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4578402	130772804	15591218	2152	6546										
OC90	729330	broad.mit.edu	37	chr8	133036749	133036749	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcttccatgaagaggcccGatccccaagggacccagtga	10	13	1	3	rs141981890	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:133036749G>A	ENST00000262283.5	-	18	2148	c.2049C>T	c.(2047-2049)atC>atT	p.I683I	OC90_ENST00000603859.1_Silent_p.I471I|OC90_ENST00000443356.2_Silent_p.I487I|OC90_ENST00000254627.3_Silent_p.I471I			Q02509	OC90_HUMAN	otoconin 90	487					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GAAGAGGCCCGATCCCCAAGG	0.577													11	12					0	0	1	0	0	A	133036749	G	A	133036749	2	1	48	1	0	0	0	0	0	0	0	1	10861	1048	37	1		1	OC90	8	133036749	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2263945	133036749	13327273	2153	6547										
LRRC6	23639	broad.mit.edu	37	chr8	133627334	133627334	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttcgttatctttcaaagaGaagtcaattctaagaataac	5	6	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:133627334G>T	ENST00000519595.1	-	8	1022	c.924C>A	c.(922-924)ttC>ttA	p.F308L	LRRC6_ENST00000518642.1_Missense_Mutation_p.F308L|LRRC6_ENST00000250173.1_Missense_Mutation_p.F308L			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	308	CS.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTTTCAAAGAGAAGTCAATTC	0.318													5	44					0.000602214	0.000636035	1	1	0	T	133627334	G	T	133627334	3	4	48	1	0	0	0	0	1	0	0	0	9060	933	33	2	496	2	LRRC6	8	133627334	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	590585	133627334	12736688	2154	6548										
TG	7038	broad.mit.edu	37	chr8	133900320	133900320	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcatgctacccaccctttcCgacacctacatcccacagtg	5	18	0	0	rs141011127		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:133900320C>T	ENST00000220616.4	+	10	2308	c.2268C>T	c.(2266-2268)tcC>tcT	p.S756S	TG_ENST00000377869.1_Silent_p.S756S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	756	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCACCCTTTCCGACACCTACA	0.587													21	34					0	0	1	0	0	T	133900320	C	T	133900320	2	4	48	1	0	0	0	0	0	0	0	1	15872	639	23	1		1	TG	8	133900320	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	272986	133900320	12463702	2155	6549										
TG	7038	broad.mit.edu	37	chr8	133961050	133961050	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgtgggttgctgagctcaCccagtgtcctgctttgtaat	11	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:133961050C>T	ENST00000220616.4	+	27	5303	c.5263C>T	c.(5263-5265)Ccc>Tcc	p.P1755S	TG_ENST00000377869.1_Missense_Mutation_p.P1698S|TG_ENST00000542445.1_Missense_Mutation_p.P125S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1755					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCTGAGCTCACCCAGTGTCCT	0.522													48	77					0	0	1	0	0	T	133961050	C	T	133961050	3	4	48	1	0	0	0	0	1	0	0	0	15872	507	18	3	5369	3	TG	8	133961050	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	60730	133961050	12402972	2156	6550										
TG	7038	broad.mit.edu	37	chr8	134031925	134031925	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttgtatctcaatgtgttCatccctcagaatgtggtgag	10	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:134031925C>A	ENST00000220616.4	+	39	6901	c.6861C>A	c.(6859-6861)ttC>ttA	p.F2287L	TG_ENST00000519543.1_Missense_Mutation_p.F420L|TG_ENST00000377869.1_Missense_Mutation_p.F2230L|TG_ENST00000542445.1_Missense_Mutation_p.F657L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2287				F -> P (in Ref. 13; AA sequence).	hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCAATGTGTTCATCCCTCAGA	0.517													20	34					4.63292e-17	6.19965e-17	1	1	0	A	134031925	C	A	134031925	3	1	48	1	0	0	0	0	1	0	0	0	15872	825	29	2	7015	2	TG	8	134031925	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	70875	134031925	12332097	2157	6551										
WISP1	8840	broad.mit.edu	37	chr8	134232915	134232915	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtacaactgcacgtgcatCgacggcgcggtgggctgcac	14	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:134232915C>T	ENST00000250160.6	+	3	547	c.441C>T	c.(439-441)atC>atT	p.I147I	WISP1_ENST00000517423.1_Intron|WISP1_ENST00000377863.2_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000220856.6_Intron	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	147	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GCACGTGCATCGACGGCGCGG	0.662													44	89					0	0	1	0	0	T	134232915	C	T	134232915	2	4	48	1	0	0	0	0	0	0	0	1	17431	874	31	1		1	WISP1	8	134232915	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	200990	134232915	12131107	2158	6552										
NDRG1	10397	broad.mit.edu	37	chr8	134258875	134258875	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaccttgaggagagtggtcTttgttgggtccaattttgag	14	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:134258875T>C	ENST00000414097.2	-	13	1706	c.839A>G	c.(838-840)aAg>aGg	p.K280R	NDRG1_ENST00000518176.1_Missense_Mutation_p.K27R|NDRG1_ENST00000354944.5_Missense_Mutation_p.K210R|NDRG1_ENST00000323851.7_Missense_Mutation_p.K280R|NDRG1_ENST00000522476.1_Missense_Mutation_p.K214R|NDRG1_ENST00000537882.1_Missense_Mutation_p.K199R|NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000521414.1_5'UTR	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	280					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GAGAGTGGTCTTTGTTGGGTC	0.443			T	ERG	prostate								5	85					0	0	1	0	0	C	134258875	T	C	134258875	3	2	48	1	0	0	0	0	1	0	0	0	10297	1609	56	4	361	4	NDRG1	8	134258875	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	25960	134258875	12105147	2159	6553										
FAM135B	51059	broad.mit.edu	37	chr8	139153578	139153578	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatgatgatgttgccaagaGaatggccaatgaagctgtgg	15	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139153578G>T	ENST00000395297.1	-	17	3823	c.3653C>A	c.(3652-3654)tCt>tAt	p.S1218Y		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1218										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTTGCCAAGAGAATGGCCAAT	0.552										HNSCC(54;0.14)			36	63					6.84511e-11	8.46308e-11	1	1	0	T	139153578	G	T	139153578	3	4	48	1	0	0	0	0	1	0	0	0	5480	942	33	2	583	2	FAM135B	8	139153578	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4894703	139153578	7210444	2160	6554										
FAM135B	51059	broad.mit.edu	37	chr8	139160910	139160910	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcagttcttttttaaattTttctttggcctgataaaaac	4	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139160910T>G	ENST00000395297.1	-	14	3471	c.3301A>C	c.(3301-3303)Aaa>Caa	p.K1101Q		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1101										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTTTAAATTTTTCTTTGGCC	0.368										HNSCC(54;0.14)			5	22					0	0	1	0	0	G	139160910	T	G	139160910	3	3	48	1	0	0	0	0	1	0	0	0	5480	1850	64	4	947	4	FAM135B	8	139160910	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7332	139160910	7203112	2161	6555										
FAM135B	51059	broad.mit.edu	37	chr8	139164359	139164359	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccatcttgctgcttggtgtCcgcatcttcagcagcctcct	8	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139164359C>T	ENST00000395297.1	-	13	2529	c.2359G>A	c.(2359-2361)Gac>Aac	p.D787N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	787								p.D787Y(2)|p.D787N(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGCTTGGTGTCCGCATCTTCA	0.522										HNSCC(54;0.14)			28	42					0	0	1	0	0	T	139164359	C	T	139164359	3	4	48	1	0	0	0	0	1	0	0	0	5480	855	30	3	1893	3	FAM135B	8	139164359	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3449	139164359	7199663	2162	6556										
FAM135B	51059	broad.mit.edu	37	chr8	139164633	139164633	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcgggcctctgaccaggcGacggagcttggctcactctc	12	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139164633G>A	ENST00000395297.1	-	13	2255	c.2085C>T	c.(2083-2085)gtC>gtT	p.V695V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	695										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGACCAGGCGACGGAGCTTG	0.552										HNSCC(54;0.14)			24	41					0	0	1	0	0	A	139164633	G	A	139164633	2	1	48	1	0	0	0	0	0	0	0	1	5480	1045	37	1		1	FAM135B	8	139164633	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	274	139164633	7199389	2163	6557										
FAM135B	51059	broad.mit.edu	37	chr8	139164903	139164903	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagttgttttgtctgaagaGatggcattttggtggcttcc	13	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139164903G>T	ENST00000395297.1	-	13	1985	c.1815C>A	c.(1813-1815)atC>atA	p.I605I		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	605										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGTCTGAAGAGATGGCATTTT	0.453										HNSCC(54;0.14)			5	131					0.014758	0.015099	1	1	0	T	139164903	G	T	139164903	2	4	48	1	0	0	0	0	0	0	0	1	5480	932	33	2		2	FAM135B	8	139164903	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	270	139164903	7199119	2164	6558										
COL22A1	169044	broad.mit.edu	37	chr8	139620199	139620199	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggggttcctgaagggccagGctctcctggagatcccggtg	16	11	1	2	rs149644599		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139620199G>A	ENST00000303045.6	-	57	4458	c.4012C>T	c.(4012-4014)Cct>Tct	p.P1338S	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.P1318S	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1338	Collagen-like 13.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAAGGGCCAGGCTCTCCTGGA	0.527										HNSCC(7;0.00092)			10	34					0	0	1	0	0	A	139620199	G	A	139620199	3	1	48	1	0	0	0	0	1	0	0	0	3704	1203	42	3	904	3	COL22A1	8	139620199	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	455296	139620199	6743823	2165	6559										
COL22A1	169044	broad.mit.edu	37	chr8	139845316	139845316	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagggaaggatcccatccGtacataggaactctgagctc	10	12	1	1	rs141938188		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:139845316G>A	ENST00000303045.6	-	5	1257	c.811C>T	c.(811-813)Cgg>Tgg	p.R271W	COL22A1_ENST00000435777.1_Missense_Mutation_p.R271W	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	271	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GATCCCATCCGTACATAGGAA	0.507										HNSCC(7;0.00092)			20	44					0	0	1	0	0	A	139845316	G	A	139845316	3	1	48	1	0	0	0	0	1	0	0	0	3704	1144	40	1	4313	1	COL22A1	8	139845316	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	225117	139845316	6518706	2166	6560										
TRAPPC9	83696	broad.mit.edu	37	chr8	140922403	140922403	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggatatgattctccagcaGatgcccagcttgctgtggat	11	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:140922403G>A	ENST00000389328.4	-	20	3260	c.3246C>T	c.(3244-3246)atC>atT	p.I1082I	TRAPPC9_ENST00000389327.3_Silent_p.I975I|TRAPPC9_ENST00000438773.2_Silent_p.I984I	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	984					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TTCTCCAGCAGATGCCCAGCT	0.602													34	59					0	0	1	0	0	A	140922403	G	A	140922403	2	1	48	1	0	0	0	0	0	0	0	1	16525	932	33	3		3	TRAPPC9	8	140922403	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1077087	140922403	5441619	2167	6561										
DENND3	22898	broad.mit.edu	37	chr8	142154302	142154302	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtggacagtcatataaaaGatttcgctgcgaagctgtct	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:142154302G>T	ENST00000519811.1	+	5	749	c.679G>T	c.(679-681)Gat>Tat	p.D227Y	DENND3_ENST00000424248.1_Missense_Mutation_p.D147Y|DENND3_ENST00000262585.2_Missense_Mutation_p.D147Y			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	147	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TCATATAAAAGATTTCGCTGC	0.373													5	21					0.014758	0.015099	1	1	0	T	142154302	G	T	142154302	3	4	48	1	0	0	0	0	1	0	0	0	4460	942	33	2	453	2	DENND3	8	142154302	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1231899	142154302	4209720	2168	6562										
DENND3	22898	broad.mit.edu	37	chr8	142186774	142186774	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtccaagaaagaagtcttcGaagccaacctgaaaaccgag	9	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:142186774G>A	ENST00000519811.1	+	15	2690	c.2620G>A	c.(2620-2622)Gaa>Aaa	p.E874K	DENND3_ENST00000424248.1_Missense_Mutation_p.E742K|DENND3_ENST00000262585.2_Missense_Mutation_p.E794K			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	794										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAAGTCTTCGAAGCCAACCT	0.512													30	54					0	0	1	0	0	A	142186774	G	A	142186774	3	1	48	1	0	0	0	0	1	0	0	0	4460	1059	37	1	2434	1	DENND3	8	142186774	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	32472	142186774	4177248	2169	6563										
BAI1	575	broad.mit.edu	37	chr8	143570434	143570434	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttgtggtgggcaccgtgCtctacaggaacctgggcagc	15	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:143570434C>T	ENST00000517894.1	+	15	3385	c.2491C>T	c.(2491-2493)Ctc>Ttc	p.L831F	BAI1_ENST00000323289.5_Missense_Mutation_p.L831F			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	831					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGGCACCGTGCTCTACAGGAA	0.672													5	15					0	0	1	0	0	T	143570434	C	T	143570434	3	4	48	1	0	0	0	0	1	0	0	0	1296	797	28	3	2545	3	BAI1	8	143570434	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1383660	143570434	2793588	2170	6564										
CYP11B1	0	broad.mit.edu	37	chr8	143957711	143957711	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggccttgatggcatctggCgacagttccgcattcaacag	11	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:143957711C>T	ENST00000292427.4	-	5	932	c.900G>A	c.(898-900)tcG>tcA	p.S300S	CYP11B1_ENST00000377675.3_Silent_p.S371S|CYP11B1_ENST00000517471.1_Silent_p.S300S	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	300					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGGCATCTGGCGACAGTTCCG	0.582									Familial Hyperaldosteronism type I				12	35					0	0	1	0	0	T	143957711	C	T	143957711	2	4	48	1	0	0	0	0	0	0	0	1	4168	755	27	1		1	CYP11B1	8	143957711	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	387277	143957711	2406311	2171	6565										
FAM83H	286077	broad.mit.edu	37	chr8	144808233	144808233	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagacctcgaagcggctgTacacgcgcttctccttgcgc	11	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:144808233T>C	ENST00000388913.3	-	5	3523	c.3398A>G	c.(3397-3399)tAc>tGc	p.Y1133C		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	1133					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAAGCGGCTGTACACGCGCTT	0.701													12	26					0	0	1	0	0	C	144808233	T	C	144808233	3	2	48	1	0	0	0	0	1	0	0	0	5671	1638	57	4	145	4	FAM83H	8	144808233	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	850522	144808233	1555789	2172	6566										
EPPK1	83481	broad.mit.edu	37	chr8	144941131	144941131	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagggcccttctcgtctcGtcatcgatgtgctcggagtc	11	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:144941131G>C	ENST00000525985.1	-	2	6362	c.6291C>G	c.(6289-6291)gaC>gaG	p.D2097E				P58107	EPIPL_HUMAN	epiplakin 1	2097						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TTCTCGTCTCGTCATCGATGT	0.587													12	139					0	0	1	0	0	C	144941131	G	C	144941131	3	2	48	1	0	0	0	0	1	0	0	0	5218	1136	40	5	975	5	EPPK1	8	144941131	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	132898	144941131	1422891	2173	6567										
PLEC	5339	broad.mit.edu	37	chr8	144994413	144994413	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccgctgctggagctcgccGtaggtggccggctcccctgt	14	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:144994413G>T	ENST00000322810.4	-	32	10156	c.9987C>A	c.(9985-9987)taC>taA	p.Y3329*	PLEC_ENST00000354589.3_Nonsense_Mutation_p.Y3192*|PLEC_ENST00000354958.2_Nonsense_Mutation_p.Y3170*|PLEC_ENST00000357649.2_Nonsense_Mutation_p.Y3196*|PLEC_ENST00000436759.2_Nonsense_Mutation_p.Y3219*|PLEC_ENST00000527096.1_Nonsense_Mutation_p.Y3215*|PLEC_ENST00000356346.3_Nonsense_Mutation_p.Y3178*|PLEC_ENST00000398774.2_Nonsense_Mutation_p.Y3160*|PLEC_ENST00000345136.3_Nonsense_Mutation_p.Y3192*	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3329	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GGAGCTCGCCGTAGGTGGCCG	0.706													8	17					0.000274275	0.000292037	1	1	0	T	144994413	G	T	144994413	4	4	48	1	0	0	0	0	0	1	0	0	12099	1140	40	5	4071	5	PLEC	8	144994413	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53282	144994413	1369609	2174	6568										
DGAT1	8694	broad.mit.edu	37	chr8	145541355	145541355	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaagggcttcatggagttCtggatggtggggaccatcca	15	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:145541355C>A	ENST00000332324.4	-	11	1188	c.915G>T	c.(913-915)caG>caT	p.Q305H		NM_012079.4	NP_036211.2	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	305					triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	9	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TCATGGAGTTCTGGATGGTGG	0.602													37	68					2.32173e-10	2.84673e-10	1	1	0	A	145541355	C	A	145541355	3	1	48	1	0	0	0	0	1	0	0	0	4485	912	32	2	579	2	DGAT1	8	145541355	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	546942	145541355	822667	2175	6569										
C8orf33	65265	broad.mit.edu	37	chr8	146279537	146279537	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagagtttaggttcaatttCttttagcgtctccccgaacc	8	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr8:146279537C>A	ENST00000331434.6	+	5	798	c.684C>A	c.(682-684)ttC>ttA	p.F228L		NM_023080.2	NP_075568.1	Q9H7E9	CH033_HUMAN	chromosome 8 open reading frame 33	228										endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GGTTCAATTTCTTTTAGCGTC	0.512													55	114					1.27862e-28	1.81741e-28	1	1	0	A	146279537	C	A	146279537	3	1	48	1	0	0	0	0	1	0	0	0	2438	912	32	2	702	2	C8orf33	8	146279537	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	738182	146279537	84485	2176	6570										
DMRT2	10655	broad.mit.edu	37	chr9	1056315	1056315	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaagagcctttgctgataAagagttggagaacattatgc	11	5	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:1056315A>C	ENST00000382251.3	+	5	1057	c.728A>C	c.(727-729)aAa>aCa	p.K243T	DMRT2_ENST00000382255.3_3'UTR|DMRT2_ENST00000358146.2_Missense_Mutation_p.K243T|DMRT2_ENST00000259622.6_3'UTR|DMRT2_ENST00000302441.6_Missense_Mutation_p.K243T			Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor 2	243					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)|prostate(2)	4		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TTTGCTGATAAAGAGTTGGAG	0.493													38	73					0	0	1	0	0	C	1056315	A	C	1056315	3	2	48	1	0	0	0	0	1	0	0	0	4614	14	1	4	795	4	DMRT2	9	1056315	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08		1056315	140157116	2177	6571										
SMARCA2	6595	broad.mit.edu	37	chr9	2191349	2191349	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggcaagaaaaggccaaatCgaggaaaagccaaacctgta	10	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:2191349C>T	ENST00000382203.1	+	33	4887	c.4678C>T	c.(4678-4680)Cga>Tga	p.R1560*	SMARCA2_ENST00000382185.1_Nonsense_Mutation_p.R206*|SMARCA2_ENST00000302401.3_Nonsense_Mutation_p.R248*|SMARCA2_ENST00000357248.2_Nonsense_Mutation_p.R1542*|SMARCA2_ENST00000382186.1_Nonsense_Mutation_p.R224*|SMARCA2_ENST00000349721.2_Nonsense_Mutation_p.R1560*|SMARCA2_ENST00000324954.5_Nonsense_Mutation_p.R206*|SMARCA2_ENST00000382194.1_Nonsense_Mutation_p.R1542*			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1560					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AAGGCCAAATCGAGGAAAAGC	0.458													31	48					0	0	1	0	0	T	2191349	C	T	2191349	4	4	48	1	0	0	0	0	0	1	0	0	14822	876	31	1	4804	1	SMARCA2	9	2191349	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1135034	2191349	139022082	2178	6572										
KIAA0020	9933	broad.mit.edu	37	chr9	2831329	2831329	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggatcacacgagttgaatCgtgtgcaaatgcaatctgca	10	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:2831329C>T	ENST00000397885.2	-	6	738	c.532G>A	c.(532-534)Gat>Aat	p.D178N		NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	178	PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		CGAGTTGAATCGTGTGCAAAT	0.343													13	31					0	0	1	0	0	T	2831329	C	T	2831329	3	4	48	1	0	0	0	0	1	0	0	0	8193	884	31	1	1466	1	KIAA0020	9	2831329	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	639980	2831329	138382102	2179	6573										
GLIS3	169792	broad.mit.edu	37	chr9	4118581	4118581	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaaggacagcgctctcttCttggagcgggccgagtggga	16	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:4118581C>A	ENST00000324333.10	-	3	625	c.432G>T	c.(430-432)aaG>aaT	p.K144N	GLIS3_ENST00000381971.3_Missense_Mutation_p.K299N	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	144	Ser-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCGCTCTCTTCTTGGAGCGGG	0.562													52	74					2.29192e-23	3.20424e-23	1	1	0	A	4118581	C	A	4118581	3	1	48	1	0	0	0	0	1	0	0	0	6488	912	32	2	1927	2	GLIS3	9	4118581	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1287252	4118581	137094850	2180	6574										
JAK2	3717	broad.mit.edu	37	chr9	5066779	5066779	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taataaatattttttgacttTtgctgtcgaggttagtatgt	8	3	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5066779T>C	ENST00000381652.3	+	10	1810	c.1316T>C	c.(1315-1317)tTt>tCt	p.F439S	JAK2_ENST00000544510.1_Missense_Mutation_p.F290S|JAK2_ENST00000539801.1_Missense_Mutation_p.F439S	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	439	SH2; atypical.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TTTTTGACTTTTGCTGTCGAG	0.313		1	"T, Mis, O"	"ETV6, PCM1, BCR"	"ALL, AML, MPD,  CML"				Polycythemia Vera, Familial				9	12					0	0	1	0	0	C	5066779	T	C	5066779	3	2	48	1	0	0	0	0	1	0	0	0	7981	1841	64	4	1346	4	JAK2	9	5066779	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	948198	5066779	136146652	2181	6575										
JAK2	3717	broad.mit.edu	37	chr9	5078340	5078340	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattcatgggaatgtatgtgCcaaaaatattctgcttatca	7	6	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5078340C>T	ENST00000381652.3	+	16	2521	c.2027C>T	c.(2026-2028)gCc>gTc	p.A676V	JAK2_ENST00000544510.1_Missense_Mutation_p.A527V|AL161450.1_ENST00000601793.1_Intron|JAK2_ENST00000539801.1_Missense_Mutation_p.A676V	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	676	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		AATGTATGTGCCAAAAATATT	0.363		1	"T, Mis, O"	"ETV6, PCM1, BCR"	"ALL, AML, MPD,  CML"				Polycythemia Vera, Familial				33	68					0	0	1	0	0	T	5078340	C	T	5078340	3	4	48	1	0	0	0	0	1	0	0	0	7981	739	26	3	2081	3	JAK2	9	5078340	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11561	5078340	136135091	2182	6576										
KIAA1432	57589	broad.mit.edu	37	chr9	5757341	5757341	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctactgctggtattcaagttCttcaggaggtttccatgtca	9	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5757341C>A	ENST00000414202.2	+	17	2073	c.1882C>A	c.(1882-1884)Ctt>Att	p.L628I	KIAA1432_ENST00000449720.2_Missense_Mutation_p.L512I|KIAA1432_ENST00000381532.2_Missense_Mutation_p.L549I|KIAA1432_ENST00000418622.3_Missense_Mutation_p.L549I|KIAA1432_ENST00000251879.6_Missense_Mutation_p.L628I	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	628						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TATTCAAGTTCTTCAGGAGGT	0.388													48	111					6.3008e-33	9.03351e-33	1	1	0	A	5757341	C	A	5757341	3	1	48	1	0	0	0	0	1	0	0	0	8274	913	32	2	1707	2	KIAA1432	9	5757341	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	679001	5757341	135456090	2183	6577										
ERMP1	79956	broad.mit.edu	37	chr9	5805106	5805106	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgggatttcagaaccacttCtcccgaggataggggtaaac	12	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5805106C>A	ENST00000339450.5	-	10	1924	c.1835G>T	c.(1834-1836)aGa>aTa	p.R612I	ERMP1_ENST00000543230.1_Missense_Mutation_p.R190I|ERMP1_ENST00000214893.5_5'UTR|ERMP1_ENST00000381506.3_Intron	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	612					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		AGAACCACTTCTCCCGAGGAT	0.383													9	47					2.17888e-05	2.39107e-05	1	1	0	A	5805106	C	A	5805106	3	1	48	1	0	0	0	0	1	0	0	0	5264	913	32	2	903	2	ERMP1	9	5805106	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47765	5805106	135408325	2184	6578										
ERMP1	79956	broad.mit.edu	37	chr9	5810024	5810024	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacttaccatgtaataaaatCttttcgcaagagtatgtata	5	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5810024C>A	ENST00000339450.5	-	8	1624	c.1535G>T	c.(1534-1536)aGa>aTa	p.R512I	ERMP1_ENST00000543230.1_Missense_Mutation_p.R90I|ERMP1_ENST00000214893.5_5'UTR|ERMP1_ENST00000381506.3_Missense_Mutation_p.R288I	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	512					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		GTAATAAAATCTTTTCGCAAG	0.368													7	43					2.0095e-06	2.25447e-06	1	1	0	A	5810024	C	A	5810024	3	1	48	1	0	0	0	0	1	0	0	0	5264	913	32	2	1211	2	ERMP1	9	5810024	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4918	5810024	135403407	2185	6579										
ERMP1	79956	broad.mit.edu	37	chr9	5811254	5811254	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagaccatgtttccatgtCgatacttagaagcagcagcc	9	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5811254C>T	ENST00000339450.5	-	7	1273	c.1184G>A	c.(1183-1185)cGa>cAa	p.R395Q	ERMP1_ENST00000214893.5_5'UTR|ERMP1_ENST00000381506.3_Missense_Mutation_p.R171Q	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	395					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		GTTTCCATGTCGATACTTAGA	0.393													22	74					0	0	1	0	0	T	5811254	C	T	5811254	3	4	48	1	0	0	0	0	1	0	0	0	5264	884	31	1	1566	1	ERMP1	9	5811254	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1230	5811254	135402177	2186	6580										
KIAA2026	158358	broad.mit.edu	37	chr9	5922560	5922560	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactgatgctaaagaagaatTtatatttgttgtctgtggga	10	3	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:5922560T>G	ENST00000399933.3	-	8	3435	c.3436A>C	c.(3436-3438)Aat>Cat	p.N1146H	KIAA2026_ENST00000381461.2_Missense_Mutation_p.N1116H	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1146										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AAAGAAGAATTTATATTTGTT	0.353													14	53					0	0	1	0	0	G	5922560	T	G	5922560	3	3	48	1	0	0	0	0	1	0	0	0	8311	1841	64	4	2879	4	KIAA2026	9	5922560	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	111306	5922560	135290871	2187	6581										
RANBP6	26953	broad.mit.edu	37	chr9	6014728	6014728	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggagtggcagtttcagacaAggtcactataacttcgaggg	13	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:6014728A>C	ENST00000259569.5	-	1	890	c.880T>G	c.(880-882)Ttg>Gtg	p.L294V	RANBP6_ENST00000485372.1_Intron	NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	294					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		GTTTCAGACAAGGTCACTATA	0.398													13	29					0	0	1	0	0	C	6014728	A	C	6014728	3	2	48	1	0	0	0	0	1	0	0	0	13082	69	3	4	2441	4	RANBP6	9	6014728	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	92168	6014728	135198703	2188	6582										
RANBP6	26953	broad.mit.edu	37	chr9	6015322	6015322	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcagttcaatcttgacatCtctctgaacatcagcaggca	6	11	6	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:6015322C>T	ENST00000259569.5	-	1	296	c.286G>A	c.(286-288)Gat>Aat	p.D96N	RANBP6_ENST00000485372.1_Intron	NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	96					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTGACATCTCTCTGAACA	0.438													27	54					0	0	1	0	0	T	6015322	C	T	6015322	3	4	48	1	0	0	0	0	1	0	0	0	13082	913	32	3	3035	3	RANBP6	9	6015322	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	594	6015322	135198109	2189	6583										
KDM4C	23081	broad.mit.edu	37	chr9	6980999	6980999	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcagccagacagatatcaGctttggaaacaaggaaagga	10	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:6980999G>A	ENST00000381309.3	+	9	1561	c.996G>A	c.(994-996)caG>caA	p.Q332Q	KDM4C_ENST00000428870.2_Silent_p.Q19Q|KDM4C_ENST00000543771.1_Silent_p.Q332Q|KDM4C_ENST00000535193.1_Silent_p.Q354Q|KDM4C_ENST00000442236.2_Silent_p.Q151Q|KDM4C_ENST00000381306.3_Silent_p.Q332Q|KDM4C_ENST00000536108.1_Silent_p.Q151Q	NM_015061.3	NP_055876.2	Q9H3R0	KDM4C_HUMAN	lysine (K)-specific demethylase 4C	332					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43						ACAGATATCAGCTTTGGAAAC	0.453													19	43					0	0	1	0	0	A	6980999	G	A	6980999	2	1	48	1	0	0	0	0	0	0	0	1	8173	962	34	3		3	KDM4C	9	6980999	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	965677	6980999	134232432	2190	6584										
PTPRD	5789	broad.mit.edu	37	chr9	8404577	8404577	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccgggaatgatcatatgcGattacattcgcgtatctatt	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:8404577G>A	ENST00000381196.4	-	33	4713	c.4170C>T	c.(4168-4170)atC>atT	p.I1390I	PTPRD_ENST00000355233.5_Silent_p.I984I|PTPRD_ENST00000486161.1_Silent_p.I983I|PTPRD_ENST00000360074.4_Silent_p.I1377I|PTPRD_ENST00000397611.3_Silent_p.I980I|PTPRD_ENST00000397617.3_Silent_p.I983I|PTPRD_ENST00000397606.3_Silent_p.I983I|PTPRD_ENST00000537002.1_Silent_p.I980I|PTPRD_ENST00000540109.1_Silent_p.I1390I|PTPRD_ENST00000358503.5_Silent_p.I1368I|PTPRD_ENST00000356435.5_Silent_p.I1390I	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1390	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GATCATATGCGATTACATTCG	0.388										TSP Lung(15;0.13)			10	18					0	0	1	0	0	A	8404577	G	A	8404577	2	1	48	1	0	0	0	0	0	0	0	1	12850	1048	37	1		1	PTPRD	9	8404577	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1423578	8404577	132808854	2191	6585										
FREM1	158326	broad.mit.edu	37	chr9	14748461	14748461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgtagaatcaaagccccGcagggtgtctcccctgatga	10	12	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:14748461G>A	ENST00000380881.4	-	32	6552	c.5737C>T	c.(5737-5739)Cgg>Tgg	p.R1913W	FREM1_ENST00000422223.2_Missense_Mutation_p.R1912W|FREM1_ENST00000380894.1_Missense_Mutation_p.R448W|FREM1_ENST00000380880.3_Missense_Mutation_p.R1912W			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1912					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TCAAAGCCCCGCAGGGTGTCT	0.498													28	54					0	0	1	0	0	A	14748461	G	A	14748461	3	1	48	1	0	0	0	0	1	0	0	0	6078	1086	38	1	833	1	FREM1	9	14748461	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6343884	14748461	126464970	2192	6586										
FREM1	158326	broad.mit.edu	37	chr9	14804984	14804984	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcactacaaagtcaggagcTtcatcatttgtggggttgat	11	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:14804984T>G	ENST00000380881.4	-	20	4259	c.3444A>C	c.(3442-3444)gaA>gaC	p.E1148D	FREM1_ENST00000422223.2_Missense_Mutation_p.E1147D|FREM1_ENST00000380880.3_Missense_Mutation_p.E1147D			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1147					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTCAGGAGCTTCATCATTTG	0.358													24	36					0	0	1	0	0	G	14804984	T	G	14804984	3	3	48	1	0	0	0	0	1	0	0	0	6078	1606	56	4	3224	4	FREM1	9	14804984	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	56523	14804984	126408447	2193	6587										
TTC39B	158219	broad.mit.edu	37	chr9	15267934	15267934	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagatggtttccaaggcatCttcgaaaacgtcctggggga	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:15267934C>A	ENST00000355694.2	-	2	289	c.55G>T	c.(55-57)Gat>Tat	p.D19Y	TTC39B_ENST00000297615.5_Missense_Mutation_p.D85Y|TTC39B_ENST00000512701.1_Missense_Mutation_p.D85Y|TTC39B_ENST00000380850.4_Missense_Mutation_p.D85Y|TTC39B_ENST00000541445.1_Missense_Mutation_p.D19Y	NM_001168339.1|NM_152574.2	NP_001161811.1|NP_689787.2	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	19							binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)	21						TCCAAGGCATCTTCGAAAACG	0.299													15	32					3.27435e-08	3.83577e-08	1	1	0	A	15267934	C	A	15267934	3	1	48	1	0	0	0	0	1	0	0	0	16769	913	32	2	1892	2	TTC39B	9	15267934	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	462950	15267934	125945497	2194	6588										
SNAPC3	6619	broad.mit.edu	37	chr9	15453106	15453106	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagactgctagaatggaaGatttcaccttcaatgacttg	8	8	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:15453106G>T	ENST00000380821.3	+	7	1059	c.883G>T	c.(883-885)Gat>Tat	p.D295Y	SNAPC3_ENST00000380799.1_Missense_Mutation_p.D92Y	NM_001039697.1	NP_001034786.1	Q92966	SNPC3_HUMAN	small nuclear RNA activating complex, polypeptide 3, 50kDa	295					regulation of transcription, DNA-dependent|snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(2)	12				GBM - Glioblastoma multiforme(50;2.15e-06)		TAGAATGGAAGATTTCACCTT	0.393													16	59					4.14922e-12	5.21015e-12	1	1	0	T	15453106	G	T	15453106	3	4	48	1	0	0	0	0	1	0	0	0	14889	942	33	2	909	2	SNAPC3	9	15453106	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	185172	15453106	125760325	2195	6589										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18639251	18639251	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcacgtgtttgatcatataGatctggaaaccaaaaccctc	6	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:18639251G>T	ENST00000380548.4	+	7	1015		c.e7-1		ADAMTSL1_ENST00000327883.7_Splice_Site|ADAMTSL1_ENST00000380566.4_Splice_Site|ADAMTSL1_ENST00000276935.6_Splice_Site	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding	p.?(2)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGATCATATAGATCTGGAAAC	0.438													16	13					1.5739e-10	1.93697e-10	1	1	0	T	18639251	G	T	18639251	5	4	48	1	0	0	0	0	0	0	1	0	273	956	33	2	702	2	ADAMTSL1	9	18639251	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3186145	18639251	122574180	2196	6590										
FAM154A	158297	broad.mit.edu	37	chr9	18950823	18950823	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgccttggcttgaaggactCtctgggcaggtaggagtgat	15	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:18950823C>A	ENST00000380534.4	-	2	430	c.151G>T	c.(151-153)Gag>Tag	p.E51*	FAM154A_ENST00000583128.1_5'UTR|FAM154A_ENST00000380530.1_Nonsense_Mutation_p.E51*|FAM154A_ENST00000542071.1_5'UTR	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	51										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		TTGAAGGACTCTCTGGGCAGG	0.463													50	78					8.94452e-30	1.27491e-29	1	1	0	A	18950823	C	A	18950823	4	1	48	1	0	0	0	0	0	1	0	0	5493	922	32	2	1285	2	FAM154A	9	18950823	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	311572	18950823	122262608	2197	6591										
HAUS6	54801	broad.mit.edu	37	chr9	19093207	19093207	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatatttcattgcaacaaatCttgcaaaatgatacatcaga	4	7	3	2	rs142253364		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:19093207C>A	ENST00000380502.3	-	4	865	c.398G>T	c.(397-399)aGa>aTa	p.R133I	HAUS6_ENST00000380496.1_5'UTR	NM_017645.3	NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	133					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TGCAACAAATCTTGCAAAATG	0.284													14	25					0.000151284	0.00016287	1	1	0	A	19093207	C	A	19093207	3	1	48	1	0	0	0	0	1	0	0	0	7010	913	32	2	2525	2	HAUS6	9	19093207	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	142384	19093207	122120224	2198	6592										
DENND4C	55667	broad.mit.edu	37	chr9	19296187	19296187	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgaagcttttaggaaatTtcttatgtttatctacaaac	5	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:19296187T>G	ENST00000380432.2	+	2	308	c.275T>G	c.(274-276)tTt>tGt	p.F92C	DENND4C_ENST00000434457.2_Missense_Mutation_p.F328C|DENND4C_ENST00000602925.1_Missense_Mutation_p.F328C|DENND4C_ENST00000307015.9_5'UTR	NM_017925.4	NP_060395.5	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	92	DENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TTTAGGAAATTTCTTATGTTT	0.368													34	64					0	0	1	0	0	G	19296187	T	G	19296187	3	3	48	1	0	0	0	0	1	0	0	0	4463	1841	64	4	281	4	DENND4C	9	19296187	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	202980	19296187	121917244	2199	6593										
DENND4C	55667	broad.mit.edu	37	chr9	19346945	19346945	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgggttctgtagtaaattCtttgtcagggctaaagctgg	13	5	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:19346945C>A	ENST00000307015.9	+	19	3494	c.1742C>A	c.(1741-1743)tCt>tAt	p.S581Y	DENND4C_ENST00000434457.2_Missense_Mutation_p.S1393Y|DENND4C_ENST00000380432.2_Missense_Mutation_p.S1108Y|DENND4C_ENST00000602925.1_Missense_Mutation_p.S1344Y|DENND4C_ENST00000540671.1_Missense_Mutation_p.S438Y			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1108						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GTAGTAAATTCTTTGTCAGGG	0.463													10	32					3.86212e-05	4.21111e-05	1	1	0	A	19346945	C	A	19346945	3	1	48	1	0	0	0	0	1	0	0	0	4463	913	32	2	3393	2	DENND4C	9	19346945	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	50758	19346945	121866486	2200	6594										
SLC24A2	25769	broad.mit.edu	37	chr9	19576994	19576994	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcttggcgatcttgtggaGaattgaagccttttctctga	10	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:19576994G>T	ENST00000341998.2	-	5	1217	c.1156C>A	c.(1156-1158)Ctc>Atc	p.L386I	SLC24A2_ENST00000286344.3_Missense_Mutation_p.L369I	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	386					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		ATCTTGTGGAGAATTGAAGCC	0.502													38	55					2.40579e-17	3.22781e-17	1	1	0	T	19576994	G	T	19576994	3	4	48	1	0	0	0	0	1	0	0	0	14520	942	33	2	853	2	SLC24A2	9	19576994	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	230049	19576994	121636437	2201	6595										
MLLT3	4300	broad.mit.edu	37	chr9	20414132	20414132	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctttcagtggtttattttCtttgggtttcttagaggatt	9	4	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:20414132C>A	ENST00000380338.4	-	5	998	c.712G>T	c.(712-714)Gaa>Taa	p.E238*	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Nonsense_Mutation_p.E235*|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		GGTTTATTTTCTTTGGGTTTC	0.383			T	MLL	ALL								64	124					1.33661e-31	1.91338e-31	1	1	0	A	20414132	C	A	20414132	4	1	48	1	0	0	0	0	0	1	0	0	9675	922	32	2	1022	2	MLLT3	9	20414132	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	837138	20414132	120799299	2202	6596										
IFNA7	3444	broad.mit.edu	37	chr9	21201822	21201822	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcttccaggtcattcagttGctggtaaagttcagtggaaa	11	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:21201822G>A	ENST00000239347.3	-	1	382	c.343C>T	c.(343-345)Caa>Taa	p.Q115*		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	115					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCATTCAGTTGCTGGTAAAGT	0.478													59	100					0	0	1	0	0	A	21201822	G	A	21201822	4	1	48	1	0	0	0	0	0	1	0	0	7585	1328	46	3	230	3	IFNA7	9	21201822	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	787690	21201822	120011609	2203	6597										
KLHL9	55958	broad.mit.edu	37	chr9	21334077	21334077	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacgcaggtattgtctgttCtcatgaaatctactgtctgc	8	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:21334077C>T	ENST00000359039.4	-	1	1302	c.782G>A	c.(781-783)aGa>aAa	p.R261K	KLHL9_ENST00000537938.1_Missense_Mutation_p.R193K			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	261					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		ATTGTCTGTTCTCATGAAATC	0.413													24	56					0	0	1	0	0	T	21334077	C	T	21334077	3	4	48	1	0	0	0	0	1	0	0	0	8438	913	32	3	1075	3	KLHL9	9	21334077	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	132255	21334077	119879354	2204	6598										
IFNA2	3440	broad.mit.edu	37	chr9	21384820	21384820	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaagaaaaagatctcatgAtttctgctctgacaacctcc	5	11	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:21384820A>C	ENST00000380206.2	-	1	576	c.509T>G	c.(508-510)aTc>aGc	p.I170S		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	170					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	AGATCTCATGATTTCTGCTCT	0.383													81	141					0	0	1	0	0	C	21384820	A	C	21384820	3	2	48	1	0	0	0	0	1	0	0	0	7580	333	12	4	61	4	IFNA2	9	21384820	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	50743	21384820	119828611	2205	6599										
IFNA2	3440	broad.mit.edu	37	chr9	21384886	21384886	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcagatagagagtgattCtttggaagtatttcctcaca	8	7	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:21384886C>A	ENST00000380206.2	-	1	510	c.443G>T	c.(442-444)aGa>aTa	p.R148I		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	148					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding	p.R148I(1)		breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GAGAGTGATTCTTTGGAAGTA	0.468													84	155					2.0464e-58	2.97336e-58	1	1	0	A	21384886	C	A	21384886	3	1	48	1	0	0	0	0	1	0	0	0	7580	913	32	2	127	2	IFNA2	9	21384886	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	66	21384886	119828545	2206	6600										
MTAP	4507	broad.mit.edu	37	chr9	21815500	21815500	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagaactgaaaaatatgtGgatactccatttggcaaggt	11	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:21815500G>A	ENST00000380172.4	+	2	308	c.102G>A	c.(100-102)gtG>gtA	p.V34V	MTAP_ENST00000580900.1_Silent_p.V34V|MTAP_ENST00000460874.2_Silent_p.V51V|RP11-145E5.5_ENST00000404796.2_Silent_p.V34V|MTAP_ENST00000427788.2_3'UTR	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	34					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	AAAAATATGTGGATACTCCAT	0.323													13	22					0	0	1	0	0	A	21815500	G	A	21815500	2	1	48	1	0	0	0	0	0	0	0	1	9958	1335	47	3		3	MTAP	9	21815500	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	430614	21815500	119397931	2207	6601										
CDKN2A	1029	broad.mit.edu	37	chr9	21974699	21974699	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatcggcctccgaccgtaaCtattcggtgcgttgggcagc	14	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:21974699C>A	ENST00000304494.5	-	1	398	c.128G>T	c.(127-129)aGt>aTt	p.S43I	CDKN2A_ENST00000579122.1_Missense_Mutation_p.S43I|CDKN2A_ENST00000530628.2_Intron|CDKN2A_ENST00000498124.1_Missense_Mutation_p.S43I|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000446177.1_Missense_Mutation_p.S43I|CDKN2A_ENST00000361570.3_Intron|CDKN2A_ENST00000579755.1_Intron|CDKN2A_ENST00000494262.1_Intron|CDKN2A_ENST00000498628.2_Intron	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	43					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(23)|p.S43I(6)|p.S43fs*76(1)|p.0(1)|p.V28_V51del(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCGACCGTAACTATTCGGTGC	0.687		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			19	143					3.32936e-07	3.80431e-07	1	1	0	A	21974699	C	A	21974699	3	1	48	1	0	0	0	0	1	0	0	0	3183	565	20	5	555	5	CDKN2A	9	21974699	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	159199	21974699	119238732	2208	6602										
PLAA	9373	broad.mit.edu	37	chr9	26923230	26923230	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagcattgatgtcccctaAatcgccagttttagaatcaa	6	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:26923230A>C	ENST00000397292.3	-	7	1402	c.985T>G	c.(985-987)Tta>Gta	p.L329V	PLAA_ENST00000520884.1_Missense_Mutation_p.L329V	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	329					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		ATGTCCCCTAAATCGCCAGTT	0.393													4	83					0	0	1	0	0	C	26923230	A	C	26923230	3	2	48	1	0	0	0	0	1	0	0	0	12058	11	1	4	1434	4	PLAA	9	26923230	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4948531	26923230	114290201	2209	6603										
TEK	7010	broad.mit.edu	37	chr9	27202911	27202911	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attggatggctattctatttCttctattactatccgttaca	5	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:27202911C>A	ENST00000380036.4	+	13	2445	c.2003C>A	c.(2002-2004)tCt>tAt	p.S668Y	TEK_ENST00000406359.4_Missense_Mutation_p.S625Y|TEK_ENST00000519097.1_Missense_Mutation_p.S521Y	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	668	Fibronectin type-III 3.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TATTCTATTTCTTCTATTACT	0.403													29	59					3.73148e-12	4.68978e-12	1	1	0	A	27202911	C	A	27202911	3	1	48	1	0	0	0	0	1	0	0	0	15809	913	32	2	2053	2	TEK	9	27202911	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	279681	27202911	114010520	2210	6604										
TAF1L	138474	broad.mit.edu	37	chr9	32633900	32633900	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacacctgttttgcccaagaGaattcgactcttcttcagag	8	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:32633900G>T	ENST00000242310.4	-	1	1767	c.1678C>A	c.(1678-1680)Ctc>Atc	p.L560I	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	560					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTGCCCAAGAGAATTCGACTC	0.448													14	207					3.27435e-08	3.83577e-08	1	1	0	T	32633900	G	T	32633900	3	4	48	1	0	0	0	0	1	0	0	0	15579	942	33	2	3806	2	TAF1L	9	32633900	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5430989	32633900	108579531	2211	6605										
DCAF12	25853	broad.mit.edu	37	chr9	34088497	34088497	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagtaattcctccaggtttCatcatgattctacgggaaga	8	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:34088497C>A	ENST00000361264.4	-	9	1554	c.1213G>T	c.(1213-1215)Gaa>Taa	p.E405*	RP11-537H15.3_ENST00000448245.1_RNA	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	405						centrosome|CUL4 RING ubiquitin ligase complex				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						CTCCAGGTTTCATCATGATTC	0.483													38	71					1.60099e-16	2.13174e-16	1	1	0	A	34088497	C	A	34088497	4	1	48	1	0	0	0	0	0	1	0	0	4287	835	29	2	152	2	DCAF12	9	34088497	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1454597	34088497	107124934	2212	6606										
UBAP1	51271	broad.mit.edu	37	chr9	34250704	34250704	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctttgtgagaagggcttcGaccctcttttagtggaagag	13	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:34250704G>A	ENST00000536252.1	+	7	1713	c.1315G>A	c.(1315-1317)Gac>Aac	p.D439N	UBAP1_ENST00000543944.1_Missense_Mutation_p.D475N|UBAP1_ENST00000379186.4_Missense_Mutation_p.D378N|UBAP1_ENST00000545103.1_Missense_Mutation_p.D503N|UBAP1_ENST00000540348.1_Missense_Mutation_p.D439N|UBAP1_ENST00000297661.4_Missense_Mutation_p.D439N|UBAP1_ENST00000359544.2_Missense_Mutation_p.D439N	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	439						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			GAAGGGCTTCGACCCTCTTTT	0.468													21	47					0	0	1	0	0	A	34250704	G	A	34250704	3	1	48	1	0	0	0	0	1	0	0	0	16896	1058	37	1	1570	1	UBAP1	9	34250704	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	162207	34250704	106962727	2213	6607										
SIGMAR1	10280	broad.mit.edu	37	chr9	34637346	34637346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccactgcagctcctcgtcggGcagcacgtggcctgggtgca	14	15	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:34637346G>A	ENST00000277010.4	-	2	296	c.223C>T	c.(223-225)Ccc>Tcc	p.P75S	SIGMAR1_ENST00000477726.1_Missense_Mutation_p.P75S|SIGMAR1_ENST00000461426.1_5'UTR|SIGMAR1_ENST00000378892.1_5'UTR	NM_005866.2	NP_005857.1	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	75					ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding			large_intestine(1)|lung(1)	2					Dextromethorphan(DB00514)	TCCTCGTCGGGCAGCACGTGG	0.677													8	13					0	0	1	0	0	A	34637346	G	A	34637346	3	1	48	1	0	0	0	0	1	0	0	0	14370	1203	42	3	460	3	SIGMAR1	9	34637346	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	386642	34637346	106576085	2214	6608										
C9orf131	138724	broad.mit.edu	37	chr9	35044595	35044595	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actctgtttcaaagtcccacGtaagtgagcctatcgcagac	8	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:35044595G>A	ENST00000312292.5	+	2	2016	c.1969G>A	c.(1969-1971)Gta>Ata	p.V657I	C9orf131_ENST00000421362.2_Missense_Mutation_p.V609I|C9orf131_ENST00000354479.5_Missense_Mutation_p.V584I	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	657										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AAAGTCCCACGTAAGTGAGCC	0.527													39	73					0	0	1	0	0	A	35044595	G	A	35044595	3	1	48	1	0	0	0	0	1	0	0	0	2475	1145	40	1	1991	1	C9orf131	9	35044595	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	407249	35044595	106168836	2215	6609										
VCP	7415	broad.mit.edu	37	chr9	35060826	35060826	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcctgtagctcacgtttgAcatcctctaggcccccgatg	9	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:35060826A>G	ENST00000358901.6	-	12	2349	c.1454T>C	c.(1453-1455)gTc>gCc	p.V485A		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	485					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTCACGTTTGACATCCTCTAG	0.547													37	90					0	0	1	0	0	G	35060826	A	G	35060826	3	3	48	1	0	0	0	0	1	0	0	0	17199	275	10	4	990	4	VCP	9	35060826	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	16231	35060826	106152605	2216	6610										
FANCG	2189	broad.mit.edu	37	chr9	35079490	35079490	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctccacaggtccaggcagCtggagcccacagaggtggtc	13	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:35079490C>T	ENST00000378643.3	-	1	523	c.32G>A	c.(31-33)aGc>aAc	p.S11N		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	11					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTCCAGGCAGCTGGAGCCCAC	0.627			"Mis, N, F, S"			"AML, leukemia"		Involved in tolerance or repair of DNA crosslinks					28	52					0	0	1	0	0	T	35079490	C	T	35079490	3	4	48	1	0	0	0	0	1	0	0	0	5700	797	28	3	1892	3	FANCG	9	35079490	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18664	35079490	106133941	2217	6611										
NPR2	4882	broad.mit.edu	37	chr9	35807134	35807134	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcattgtcagcagagagcacCcccatgcaggtgagagccat	12	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:35807134C>T	ENST00000342694.2	+	17	2889	c.2634C>T	c.(2632-2634)acC>acT	p.T878T		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	878	Guanylate cyclase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CAGAGAGCACCCCCATGCAGG	0.522													13	42					0	0	1	0	0	T	35807134	C	T	35807134	2	4	48	1	0	0	0	0	0	0	0	1	10642	610	22	3		3	NPR2	9	35807134	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	727644	35807134	105406297	2218	6612										
OR13J1	392309	broad.mit.edu	37	chr9	35869824	35869824	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagtcttcgctgaccgacGtgttgccgcatgccagcttc	12	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:35869824G>A	ENST00000377981.2	-	1	637	c.575C>T	c.(574-576)aCg>aTg	p.T192M		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GCTGACCGACGTGTTGCCGCA	0.597													25	50					0	0	1	0	0	A	35869824	G	A	35869824	3	1	48	1	0	0	0	0	1	0	0	0	10991	1145	40	1	366	1	OR13J1	9	35869824	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	62690	35869824	105343607	2219	6613										
CCIN	881	broad.mit.edu	37	chr9	36169834	36169834	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgtggggctcagtatttcaAcacaccacgccttcgagttc	9	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:36169834A>G	ENST00000335119.2	+	1	446	c.335A>G	c.(334-336)aAc>aGc	p.N112S		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	112	BTB.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			CAGTATTTCAACACACCACGC	0.527													25	44					0	0	1	0	0	G	36169834	A	G	36169834	3	3	48	1	0	0	0	0	1	0	0	0	2898	43	2	4	337	4	CCIN	9	36169834	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	300010	36169834	105043597	2220	6614										
TOMM5	401505	broad.mit.edu	37	chr9	37588877	37588877	+	Nonstop_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcttcatatcgtgcattcAtatgtgatgtcctgtcttca	7	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:37588877A>G	ENST00000401811.3	-	2	366	c.295T>C	c.(295-297)Tga>Cga	p.*99R	TOMM5_ENST00000544379.1_3'UTR|RP11-613M10.8_ENST00000537239.2_3'UTR|TOMM5_ENST00000321301.6_3'UTR|TOMM5_ENST00000377773.5_3'UTR|RP11-613M10.9_ENST00000540557.1_3'UTR			Q8N4H5	TOM5_HUMAN	translocase of outer mitochondrial membrane 5 homolog (yeast)	0						integral to membrane|mitochondrial outer membrane translocase complex											TCGTGCATTCATATGTGATGT	0.363													8	21					0	0	1	0	0	G	37588877	A	G	37588877	4	3	48	1	0	0	0	0	0	0	0	0	16419	232	8	4		4	TOMM5	9	37588877	Nonstop_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1419043	37588877	103624554	2221	6615										
FRMPD1	22844	broad.mit.edu	37	chr9	37737115	37737115	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgactttgctgctggaatCcaacagtgcaaaagacctag	9	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:37737115C>T	ENST00000539465.1	+	14	2017	c.1424C>T	c.(1423-1425)tCc>tTc	p.S475F	FRMPD1_ENST00000377765.3_Missense_Mutation_p.S475F|FRMPD1_ENST00000541302.1_Missense_Mutation_p.S344F|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Missense_Mutation_p.S297F			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	475	FERM.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTGCTGGAATCCAACAGTGCA	0.458													32	59					0	0	1	0	0	T	37737115	C	T	37737115	3	4	48	1	0	0	0	0	1	0	0	0	6091	855	30	3	1474	3	FRMPD1	9	37737115	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	148238	37737115	103476316	2222	6616										
FRMPD1	22844	broad.mit.edu	37	chr9	37745053	37745053	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagaaccaaccatagagcaTggagacagctccttctccct	7	13	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:37745053T>C	ENST00000539465.1	+	16	3617	c.3024T>C	c.(3022-3024)caT>caC	p.H1008H	FRMPD1_ENST00000377765.3_Silent_p.H1008H|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1008						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CCATAGAGCATGGAGACAGCT	0.532													29	130					0	0	1	0	0	C	37745053	T	C	37745053	2	2	48	1	0	0	0	0	0	0	0	1	6091	1461	51	4		4	FRMPD1	9	37745053	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7938	37745053	103468378	2223	6617										
CNTNAP3	79937	broad.mit.edu	37	chr9	39140537	39140537	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcatattgcagtacacaaGaaatggtcccagggggccac	11	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:39140537G>T	ENST00000297668.6	-	12	1928	c.1855C>A	c.(1855-1857)Ctt>Att	p.L619I	CNTNAP3_ENST00000377659.1_Missense_Mutation_p.L619I|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.L619I|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.L526I|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.L531I	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	619	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CAGTACACAAGAAATGGTCCC	0.433													26	51					2.79863e-10	3.42475e-10	1	1	0	T	39140537	G	T	39140537	3	4	48	1	0	0	0	0	1	0	0	0	3671	942	33	2	2063	2	CNTNAP3	9	39140537	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1395484	39140537	102072894	2224	6618										
ZNF658	26149	broad.mit.edu	37	chr9	40772234	40772234	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctcccctgtgtgaattCtctggtgtactctgagagtt	10	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:40772234C>A	ENST00000602553.1	-	5	3335	c.3041G>T	c.(3040-3042)aGa>aTa	p.R1014I	ZNF658_ENST00000377626.3_Missense_Mutation_p.R1014I|ZNF658_ENST00000441795.1_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	1014					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGTGTGAATTCTCTGGTGTAC	0.443													38	84					1.62263e-30	2.3181e-30	1	1	0	A	40772234	C	A	40772234	3	1	48	1	0	0	0	0	1	0	0	0	18125	913	32	2	142	2	ZNF658	9	40772234	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1631697	40772234	100441197	2225	6619										
ZNF658	26149	broad.mit.edu	37	chr9	40774078	40774078	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggggcctctgatgctgaatGaggtgtgctttccggtaaaa	14	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:40774078G>T	ENST00000602553.1	-	5	1491	c.1197C>A	c.(1195-1197)ctC>ctA	p.L399L	ZNF658_ENST00000377626.3_Silent_p.L399L|ZNF658_ENST00000441795.1_Silent_p.L397L			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GATGCTGAATGAGGTGTGCTT	0.403													63	306					3.56336e-21	4.91459e-21	1	1	0	T	40774078	G	T	40774078	2	4	48	1	0	0	0	0	0	0	0	1	18125	1277	45	2		2	ZNF658	9	40774078	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1844	40774078	100439353	2226	6620										
PIP5K1B	8395	broad.mit.edu	37	chr9	71491678	71491678	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagcattccgatatttcagaGaactttttggtatcaagcct	7	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:71491678G>T	ENST00000265382.3	+	6	591	c.286G>T	c.(286-288)Gaa>Taa	p.E96*	PIP5K1B_ENST00000541509.1_Nonsense_Mutation_p.E96*	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	96	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		ATATTTCAGAGAACTTTTTGG	0.383													11	51					0.000673444	0.000709932	1	1	0	T	71491678	G	T	71491678	4	4	48	1	0	0	0	0	0	1	0	0	11987	943	33	2	296	2	PIP5K1B	9	71491678	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30717600	71491678	69721753	2227	6621										
GDA	9615	broad.mit.edu	37	chr9	74817652	74817652	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagaagaagtatataccagAgttgtcgtaagtatcttgtg	11	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:74817652A>G	ENST00000358399.3	+	3	471	c.378A>G	c.(376-378)agA>agG	p.R126R	GDA_ENST00000477618.1_3'UTR|GDA_ENST00000376986.1_Silent_p.R84R|GDA_ENST00000545168.1_Silent_p.R52R|GDA_ENST00000376989.3_Silent_p.R101R|GDA_ENST00000238018.4_Silent_p.R126R	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	126					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		TATATACCAGAGTTGTCGTAA	0.398													11	113					0	0	1	0	0	G	74817652	A	G	74817652	2	3	48	1	0	0	0	0	0	0	0	1	6346	301	11	4		4	GDA	9	74817652	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3325974	74817652	66395779	2228	6622										
ZFAND5	0	broad.mit.edu	37	chr9	74975687	74975687	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggggtctggttagtctccTgagccatatttttctgctat	10	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:74975687T>G	ENST00000237937.3	-	2	565	c.8A>C	c.(7-9)cAg>cCg	p.Q3P	ZFAND5_ENST00000376960.4_Missense_Mutation_p.Q3P|ZFAND5_ENST00000488164.1_5'UTR|ZFAND5_ENST00000376962.5_Missense_Mutation_p.Q3P|ZFAND5_ENST00000343431.2_Missense_Mutation_p.Q3P	NM_001102421.1|NM_001278243.1|NM_001278244.1|NM_001278245.1|NM_006007.2	NP_001095891.1|NP_001265172.1|NP_001265173.1|NP_001265174.1|NP_005998.1	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	3							DNA binding|zinc ion binding			cervix(1)|kidney(2)|lung(2)|prostate(1)	6						GTTAGTCTCCTGAGCCATATT	0.388													5	99					0	0	1	0	0	G	74975687	T	G	74975687	3	3	48	1	0	0	0	0	1	0	0	0	17687	1580	55	4	653	4	ZFAND5	9	74975687	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	158035	74975687	66237744	2229	6623										
TMC1	117531	broad.mit.edu	37	chr9	75445593	75445593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagaaaatggcagctgcacGagcaggttggagatacgttt	13	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:75445593G>A	ENST00000297784.5	+	23	2795	c.2255G>A	c.(2254-2256)cGa>cAa	p.R752Q	TMC1_ENST00000486417.1_3'UTR|TMC1_ENST00000396237.3_Missense_Mutation_p.R752Q|TMC1_ENST00000340019.3_Missense_Mutation_p.R752Q	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	752	Poly-Ala.				sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						GCAGCTGCACGAGCAGGTTGG	0.323													9	17					0	0	1	0	0	A	75445593	G	A	75445593	3	1	48	1	0	0	0	0	1	0	0	0	16043	1058	37	1	2329	1	TMC1	9	75445593	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	469906	75445593	65767838	2230	6624										
ALDH1A1	216	broad.mit.edu	37	chr9	75545819	75545819	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagcagacgatctctttcGattaaatcagccaacttgta	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:75545819G>A	ENST00000297785.3	-	3	342	c.288C>T	c.(286-288)atC>atT	p.I96I	ALDH1A1_ENST00000376939.1_Silent_p.I96I|ALDH1A1_ENST00000482210.1_5'UTR	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	96					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity	p.I96I(1)|p.I110I(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GATCTCTTTCGATTAAATCAG	0.483													36	69					0	0	1	0	0	A	75545819	G	A	75545819	2	1	48	1	0	0	0	0	0	0	0	1	487	1048	37	1		1	ALDH1A1	9	75545819	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	100226	75545819	65667612	2231	6625										
RORB	6096	broad.mit.edu	37	chr9	77275552	77275552	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccgaattgcacagaacatCattaagtcccatttggagac	8	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:77275552C>A	ENST00000376896.2	+	5	1269	c.657C>A	c.(655-657)atC>atA	p.I219I	RORB_ENST00000396204.2_Silent_p.I230I	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	230	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						CACAGAACATCATTAAGTCCC	0.378													39	67					1.04594e-18	1.41924e-18	1	1	0	A	77275552	C	A	77275552	2	1	48	1	0	0	0	0	0	0	0	1	13580	816	29	2		2	RORB	9	77275552	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1729733	77275552	63937879	2232	6626										
PCSK5	5125	broad.mit.edu	37	chr9	78790136	78790136	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaatggaatggaatggaaTgaaatggaatggaatgaaat	13	1	0	3	rs62556589		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:78790136T>C	ENST00000376767.3	+	14	2503	c.1991T>C	c.(1990-1992)aTg>aCg	p.M664T	PCSK5_ENST00000545128.1_Intron|PCSK5_ENST00000376752.4_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						tggaatggaatgaaatggaat	0.423													5	24					0	0	1	0	0	C	78790136	T	C	78790136	3	2	48	1	0	0	0	0	1	0	0	0	11649	1479	51	4		4	PCSK5	9	78790136	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1514584	78790136	62423295	2233	6627										
PRUNE2	158471	broad.mit.edu	37	chr9	79318459	79318459	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggctgactggaccagaggcTtcctctagtgccaaagattc	11	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:79318459T>G	ENST00000428286.1	-	9	8193	c.6993A>C	c.(6991-6993)gaA>gaC	p.E2331D	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2690D			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2690					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GACCAGAGGCTTCCTCTAGTG	0.552													31	43					0	0	1	0	0	G	79318459	T	G	79318459	3	3	48	1	0	0	0	0	1	0	0	0	12689	1606	56	4	1240	4	PRUNE2	9	79318459	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	528323	79318459	61894972	2234	6628										
PRUNE2	158471	broad.mit.edu	37	chr9	79324748	79324748	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgggtgcaaattccaggtAttttttaaagcttcatcatg	9	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:79324748A>C	ENST00000428286.1	-	8	2565	c.1365T>G	c.(1363-1365)aaT>aaG	p.N455K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.N814K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	814					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AATTCCAGGTATTTTTTAAAG	0.478													10	23					0	0	1	0	0	C	79324748	A	C	79324748	3	2	48	1	0	0	0	0	1	0	0	0	12689	446	16	4	6872	4	PRUNE2	9	79324748	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6289	79324748	61888683	2235	6629										
PRUNE2	158471	broad.mit.edu	37	chr9	79520871	79520871	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttggcgcgttgcaaaaaTtcttccatgtcgtggctagg	12	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:79520871T>C	ENST00000376718.3	-	1	132	c.9A>G	c.(7-9)gaA>gaG	p.E3E	PRUNE2_ENST00000376713.3_Silent_p.E3E|PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	3					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTTGCAAAAATTCTTCCATGT	0.557													35	48					0	0	1	0	0	C	79520871	T	C	79520871	2	2	48	1	0	0	0	0	0	0	0	1	12689	1490	52	4		4	PRUNE2	9	79520871	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	196123	79520871	61692560	2236	6630										
TLE4	7091	broad.mit.edu	37	chr9	82191078	82191078	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcctatgggttgaatataGaaatgcacaagcaggtaagt	11	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:82191078G>T	ENST00000376520.4	+	4	1066	c.238G>T	c.(238-240)Gaa>Taa	p.E80*	TLE4_ENST00000376544.3_Nonsense_Mutation_p.E80*|TLE4_ENST00000265284.6_Nonsense_Mutation_p.E80*|TLE4_ENST00000376552.2_Nonsense_Mutation_p.E80*|TLE4_ENST00000376537.4_Nonsense_Mutation_p.E80*|TLE4_ENST00000455913.1_3'UTR|TLE4_ENST00000376534.4_5'UTR			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GTTGAATATAGAAATGCACAA	0.303													23	41					3.28513e-13	4.19729e-13	1	1	0	T	82191078	G	T	82191078	4	4	48	1	0	0	0	0	0	1	0	0	16000	943	33	2	252	2	TLE4	9	82191078	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2670207	82191078	59022353	2237	6631										
RASEF	158158	broad.mit.edu	37	chr9	85611950	85611950	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcatatctacccattctcGtatgttaagaaagcttttct	4	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:85611950G>A	ENST00000376447.3	-	14	2157	c.1897C>T	c.(1897-1899)Cga>Tga	p.R633*		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	633					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						ACCCATTCTCGTATGTTAAGA	0.373													11	26					0	0	1	0	0	A	85611950	G	A	85611950	4	1	48	1	0	0	0	0	0	1	0	0	13119	1153	40	1	341	1	RASEF	9	85611950	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3420872	85611950	55601481	2238	6632										
KIF27	55582	broad.mit.edu	37	chr9	86465162	86465162	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagaactttcattttcatTtcttcattatataactgttg	3	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:86465162T>G	ENST00000297814.2	-	16	3551	c.3408A>C	c.(3406-3408)gaA>gaC	p.E1136D	RP11-575L7.4_ENST00000590813.1_RNA|RP11-575L7.4_ENST00000586206.1_RNA|KIF27_ENST00000413982.1_Missense_Mutation_p.E1070D|RP11-575L7.4_ENST00000589817.1_RNA|KIF27_ENST00000334204.2_Missense_Mutation_p.E1039D|RP11-575L7.4_ENST00000590368.1_RNA|RP11-575L7.4_ENST00000591217.1_RNA	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	1136					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TCATTTTCATTTCTTCATTAT	0.383													14	46					0	0	1	0	0	G	86465162	T	G	86465162	3	3	48	1	0	0	0	0	1	0	0	0	8337	1838	64	4	809	4	KIF27	9	86465162	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	853212	86465162	54748269	2239	6633										
NAA35	60560	broad.mit.edu	37	chr9	88590040	88590040	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttctaggcatgctaaaaGatgtggaggatgacatgcaa	11	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:88590040G>T	ENST00000361671.5	+	8	728	c.595G>T	c.(595-597)Gat>Tat	p.D199Y	NAA35_ENST00000376040.1_Missense_Mutation_p.D199Y	NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	199					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						CATGCTAAAAGATGTGGAGGA	0.294													18	36					8.34094e-07	9.42356e-07	1	1	0	T	88590040	G	T	88590040	3	4	48	1	0	0	0	0	1	0	0	0	10170	942	33	2	621	2	NAA35	9	88590040	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2124878	88590040	52623391	2240	6634										
NAA35	60560	broad.mit.edu	37	chr9	88622302	88622302	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtggataacaaaaaggtCtttggaactcatctcatgca	9	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:88622302C>A	ENST00000361671.5	+	14	1279	c.1146C>A	c.(1144-1146)gtC>gtA	p.V382V		NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	382					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						ACAAAAAGGTCTTTGGAACTC	0.383													7	100					0.00307968	0.00320271	1	1	0	A	88622302	C	A	88622302	2	1	48	1	0	0	0	0	0	0	0	1	10170	900	32	2		2	NAA35	9	88622302	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32262	88622302	52591129	2241	6635										
ZCCHC6	79670	broad.mit.edu	37	chr9	88955947	88955947	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaacattcttgaacaagtaAgaggacatctggctgagaca	9	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:88955947A>C	ENST00000375961.2	-	7	1322	c.1108T>G	c.(1108-1110)Tta>Gta	p.L370V	ZCCHC6_ENST00000375948.1_Missense_Mutation_p.L8V|ZCCHC6_ENST00000375963.3_Missense_Mutation_p.L370V|ZCCHC6_ENST00000277141.6_5'UTR|ZCCHC6_ENST00000375960.2_Intron			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	370					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						TGAACAAGTAAGAGGACATCT	0.313													14	52					0	0	1	0	0	C	88955947	A	C	88955947	3	2	48	1	0	0	0	0	1	0	0	0	17649	69	3	4	3463	4	ZCCHC6	9	88955947	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	333645	88955947	52257484	2242	6636										
C9orf170	401535	broad.mit.edu	37	chr9	89771500	89771500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctataggttctgtttctcCggaaaaccctgactaataca	6	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:89771500C>T	ENST00000375941.2	+	2	268	c.181C>T	c.(181-183)Cgg>Tgg	p.R61W		NM_001001709.2	NP_001001709.1	A2RU37	CI170_HUMAN	chromosome 9 open reading frame 170	61										large_intestine(3)|lung(2)|prostate(1)	6						tctgtttctccggaaaaccct	0.378													6	8					0	0	1	0	0	T	89771500	C	T	89771500	3	4	48	1	0	0	0	0	1	0	0	0	2487	643	23	1	187	1	C9orf170	9	89771500	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	815553	89771500	51441931	2243	6637										
SPIN1	10927	broad.mit.edu	37	chr9	91090060	91090060	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtaggcaaacaagtggaAtatgccaaagaagatggctc	12	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:91090060A>C	ENST00000375859.3	+	6	935	c.657A>C	c.(655-657)gaA>gaC	p.E219D	SPIN1_ENST00000469017.2_3'UTR|SPIN1_ENST00000541629.1_Missense_Mutation_p.E219D	NM_006717.2	NP_006708.2	Q9Y657	SPIN1_HUMAN	spindlin 1	219					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						AACAAGTGGAATATGCCAAAG	0.393													17	45					0	0	1	0	0	C	91090060	A	C	91090060	3	2	48	1	0	0	0	0	1	0	0	0	15107	98	4	4	675	4	SPIN1	9	91090060	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1318560	91090060	50123371	2244	6638										
NFIL3	4783	broad.mit.edu	37	chr9	94171927	94171927	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcactatgcttttcgagttCgaaatgtcttttagatgtca	9	7	2	1	rs34945709		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:94171927C>T	ENST00000297689.3	-	2	1484	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_005384.2	NP_005375.2	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	364					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	16						TTTTCGAGTTCGAAATGTCTT	0.408													48	91					0	0	1	0	0	T	94171927	C	T	94171927	3	4	48	1	0	0	0	0	1	0	0	0	10419	893	31	1	302	1	NFIL3	9	94171927	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3081867	94171927	47041504	2245	6639										
NFIL3	4783	broad.mit.edu	37	chr9	94172299	94172299	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttgatagatggacgctgTgtaagagcctcggtcatctc	12	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:94172299T>C	ENST00000297689.3	-	2	1112	c.718A>G	c.(718-720)Aca>Gca	p.T240A		NM_005384.2	NP_005375.2	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	240					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	16						ATGGACGCTGTGTAAGAGCCT	0.488													26	56					0	0	1	0	0	C	94172299	T	C	94172299	3	2	48	1	0	0	0	0	1	0	0	0	10419	1696	59	4	674	4	NFIL3	9	94172299	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	372	94172299	47041132	2246	6640										
SPTLC1	10558	broad.mit.edu	37	chr9	94874756	94874756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttgactgtaagatcagatCgttcttgtaatttgtaagtc	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:94874756C>T	ENST00000262554.2	-	2	151	c.146G>A	c.(145-147)cGa>cAa	p.R49Q	SPTLC1_ENST00000337841.4_Missense_Mutation_p.R49Q|SPTLC1_ENST00000482632.1_5'UTR	NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	49						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AAGATCAGATCGTTCTTGTAA	0.363													6	19					0	0	1	0	0	T	94874756	C	T	94874756	3	4	48	1	0	0	0	0	1	0	0	0	15178	884	31	1	1340	1	SPTLC1	9	94874756	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	702457	94874756	46338675	2247	6641										
ASPN	54829	broad.mit.edu	37	chr9	95237107	95237107	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcatcatattcttcagtgCgatgtgtgaagggctaaaga	11	7	3	2	rs146516859		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:95237107C>T	ENST00000375544.3	-	2	316	c.73G>A	c.(73-75)Gca>Aca	p.A25T	ASPN_ENST00000395538.3_Missense_Mutation_p.A25T|ASPN_ENST00000450139.2_5'UTR|CENPP_ENST00000375587.3_Intron|ASPN_ENST00000375543.1_Missense_Mutation_p.A25T	NM_017680.4	NP_060150.4	Q9BXN1	ASPN_HUMAN	asporin	25					bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9						TTCTTCAGTGCGATGTGTGAA	0.423													17	21					0	0	1	0	0	T	95237107	C	T	95237107	3	4	48	1	0	0	0	0	1	0	0	0	1056	768	27	1	1097	1	ASPN	9	95237107	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	362351	95237107	45976324	2248	6642										
ZNF484	83744	broad.mit.edu	37	chr9	95608521	95608521	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taattctaactagatagaagAaagttggccttggtcacctt	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:95608521A>G	ENST00000395505.2	-	3	2532	c.2440T>C	c.(2440-2442)Tct>Cct	p.S814P	ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000332591.6_Missense_Mutation_p.S814P|ZNF484_ENST00000375495.3_Missense_Mutation_p.S850P|ZNF484_ENST00000395506.3_Missense_Mutation_p.S852P	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	850					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						TAGATAGAAGAAAGTTGGCCT	0.423													33	62					0	0	1	0	0	G	95608521	A	G	95608521	3	3	48	1	0	0	0	0	1	0	0	0	17993	246	9	4	14	4	ZNF484	9	95608521	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	371414	95608521	45604910	2249	6643										
SUSD3	203328	broad.mit.edu	37	chr9	95840161	95840161	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgagacctttggcttcaaggTggccgtgatcgcctccattg	12	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:95840161T>C	ENST00000375472.3	+	3	347	c.311T>C	c.(310-312)gTg>gCg	p.V104A	SUSD3_ENST00000375469.1_Missense_Mutation_p.V91A	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	104						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						GGCTTCAAGGTGGCCGTGATC	0.597													23	54					0	0	1	0	0	C	95840161	T	C	95840161	3	2	48	1	0	0	0	0	1	0	0	0	15464	1696	59	4	321	4	SUSD3	9	95840161	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	231640	95840161	45373270	2250	6644										
PTCH1	5727	broad.mit.edu	37	chr9	98244436	98244436	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgatccatgtaacctgtttCtgtgataagctctcctgatt	7	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:98244436C>A	ENST00000430669.2	-	4	1021	c.436G>T	c.(436-438)Gaa>Taa	p.E146*	PTCH1_ENST00000418258.1_Nonsense_Mutation_p.E61*|PTCH1_ENST00000421141.1_Nonsense_Mutation_p.E61*|PTCH1_ENST00000375274.2_Nonsense_Mutation_p.E211*|PTCH1_ENST00000429896.2_Nonsense_Mutation_p.E61*|PTCH1_ENST00000437951.1_Nonsense_Mutation_p.E146*|PTCH1_ENST00000548379.1_5'UTR|PTCH1_ENST00000468211.2_Nonsense_Mutation_p.E146*|PTCH1_ENST00000331920.6_Nonsense_Mutation_p.E212*			Q13635	PTC1_HUMAN	patched 1	212					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.E212fs*40(1)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TAACCTGTTTCTGTGATAAGC	0.363													18	26					6.49762e-13	8.24929e-13	1	1	0	A	98244436	C	A	98244436	4	1	48	1	0	0	0	0	0	1	0	0	12778	922	32	2	3789	2	PTCH1	9	98244436	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2404275	98244436	42968995	2251	6645										
ZNF510	22869	broad.mit.edu	37	chr9	99521061	99521061	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggattttctagttattacatCaatagggattcccctctccc	6	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:99521061C>T	ENST00000375231.1	-	6	2701	c.2051G>A	c.(2050-2052)tGa>tAa	p.*684*	ZNF510_ENST00000223428.4_Silent_p.*684*			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				GTTATTACATCAATAGGGATT	0.358													7	29					0	0	1	0	0	T	99521061	C	T	99521061	2	4	48	1	0	0	0	0	0	0	0	1	18010	837	29	3		3	ZNF510	9	99521061	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1276625	99521061	41692370	2252	6646										
NCBP1	4686	broad.mit.edu	37	chr9	100418013	100418013	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggttttctcatcatctaaGtaacttccagttccgttgga	7	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:100418013G>A	ENST00000375147.3	+	13	1521	c.1265G>A	c.(1264-1266)aGt>aAt	p.S422N		NM_002486.4	NP_002477.1	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	422					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)	19		Acute lymphoblastic leukemia(62;0.158)				CATCATCTAAGTAACTTCCAG	0.343													5	23					0	0	1	0	0	A	100418013	G	A	100418013	3	1	48	1	0	0	0	0	1	0	0	0	10257	1029	36	3	1315	3	NCBP1	9	100418013	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	896952	100418013	40795418	2253	6647										
HEMGN	55363	broad.mit.edu	37	chr9	100692679	100692679	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagagggggctttaggcacaAtaatttcgttacatgtttta	11	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:100692679A>C	ENST00000259456.3	-	4	1141	c.998T>G	c.(997-999)aTt>aGt	p.I333S		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	333					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				TTTAGGCACAATAATTTCGTT	0.348													8	132					0	0	1	0	0	C	100692679	A	C	100692679	3	2	48	1	0	0	0	0	1	0	0	0	7090	101	4	4	464	4	HEMGN	9	100692679	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	274666	100692679	40520752	2254	6648										
TBC1D2	55357	broad.mit.edu	37	chr9	100961799	100961799	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctccagccgctcccggtggAccatgcgcagctgccgcagc	12	19	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:100961799A>G	ENST00000375066.5	-	13	2709	c.2618T>C	c.(2617-2619)gTc>gCc	p.V873A	TBC1D2_ENST00000342112.5_Missense_Mutation_p.V666A|TBC1D2_ENST00000375063.1_Missense_Mutation_p.V424A|TBC1D2_ENST00000375064.1_3'UTR	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	884						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CTCCCGGTGGACCATGCGCAG	0.637													89	171					0	0	1	0	0	G	100961799	A	G	100961799	3	3	48	1	0	0	0	0	1	0	0	0	15664	275	10	4	139	4	TBC1D2	9	100961799	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	269120	100961799	40251632	2255	6649										
GABBR2	9568	broad.mit.edu	37	chr9	101340240	101340240	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccagattccagccttggaGggactctgcaatgatggatg	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:101340240G>T	ENST00000259455.2	-	2	895	c.436C>A	c.(436-438)Ctc>Atc	p.L146I		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	146					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CAGCCTTGGAGGGACTCTGCA	0.493													22	47					6.44725e-10	7.85205e-10	1	1	0	T	101340240	G	T	101340240	3	4	48	1	0	0	0	0	1	0	0	0	6190	1000	35	5	2461	5	GABBR2	9	101340240	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	378441	101340240	39873191	2256	6650										
GALNT12	79695	broad.mit.edu	37	chr9	101585576	101585576	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgattatgataatttgcccaGgacatctgttatcatagcat	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:101585576G>T	ENST00000375011.3	+	2	410	c.410G>T	c.(409-411)aGg>aTg	p.R137M		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	137	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				AATTTGCCCAGGACATCTGTT	0.453													20	37					2.4624e-09	2.95225e-09	1	1	0	T	101585576	G	T	101585576	3	4	48	1	0	0	0	0	1	0	0	0	6249	1000	35	5	416	5	GALNT12	9	101585576	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	245336	101585576	39627855	2257	6651										
GALNT12	79695	broad.mit.edu	37	chr9	101589141	101589141	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcccggctgctgggggcgTctgcggcgaggggcgatgtt	21	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:101589141T>C	ENST00000375011.3	+	3	649	c.649T>C	c.(649-651)Tct>Cct	p.S217P		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	217	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				GCTGGGGGCGTCTGCGGCGAG	0.667													7	10					0	0	1	0	0	C	101589141	T	C	101589141	3	2	48	1	0	0	0	0	1	0	0	0	6249	1667	58	4	659	4	GALNT12	9	101589141	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3565	101589141	39624290	2258	6652										
GALNT12	79695	broad.mit.edu	37	chr9	101594117	101594117	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatcgactggaacaccttCgaatacctggggaactccgg	12	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:101594117C>T	ENST00000375011.3	+	4	795	c.795C>T	c.(793-795)ttC>ttT	p.F265F		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	265						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				GGAACACCTTCGAATACCTGG	0.572													25	23					0	0	1	0	0	T	101594117	C	T	101594117	2	4	48	1	0	0	0	0	0	0	0	1	6249	883	31	1		1	GALNT12	9	101594117	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4976	101594117	39619314	2259	6653										
LPPR1	0	broad.mit.edu	37	chr9	104032271	104032271	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacggagacttaatgaagcCttacccagggacagaggaag	14	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:104032271C>A	ENST00000374874.3	+	3	612	c.173C>A	c.(172-174)cCt>cAt	p.P58H	LPPR1_ENST00000395056.2_Missense_Mutation_p.P58H	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		58						integral to membrane	catalytic activity										TTAATGAAGCCTTACCCAGGG	0.483													7	38					8.12818e-05	8.79784e-05	1	1	0	A	104032271	C	A	104032271	3	1	48	1	0	0	0	0	1	0	0	0	8968	681	24	5	179	5	LPPR1	9	104032271	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2438154	104032271	37181160	2260	6654										
ZNF189	7743	broad.mit.edu	37	chr9	104171636	104171636	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagctttgtaatcttattcGacatcagggtgttcacacag	8	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:104171636G>A	ENST00000374861.3	+	3	1828	c.1544G>A	c.(1543-1545)cGa>cAa	p.R515Q	ZNF189_ENST00000339664.2_Missense_Mutation_p.R529Q|ZNF189_ENST00000259395.4_Missense_Mutation_p.R487Q	NM_001278231.1|NM_001278232.1|NM_003452.2	NP_001265160.1|NP_001265161.1|NP_003443.2	O75820	ZN189_HUMAN	zinc finger protein 189	529					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				AATCTTATTCGACATCAGGGT	0.423													11	38					0	0	1	0	0	A	104171636	G	A	104171636	3	1	48	1	0	0	0	0	1	0	0	0	17811	1058	37	1	1596	1	ZNF189	9	104171636	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	139365	104171636	37041795	2261	6655										
RNF20	56254	broad.mit.edu	37	chr9	104316369	104316369	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcagctgatggcagctgaGaagaagtctaaggcagaggt	15	6	2	4	rs147900751	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:104316369G>A	ENST00000389120.3	+	14	2091	c.2001G>A	c.(1999-2001)gaG>gaA	p.E667E		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	667					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TGGCAGCTGAGAAGAAGTCTA	0.428													20	42					0	0	1	0	0	A	104316369	G	A	104316369	2	1	48	1	0	0	0	0	0	0	0	1	13524	933	33	3		3	RNF20	9	104316369	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	144733	104316369	36897062	2262	6656										
RNF20	56254	broad.mit.edu	37	chr9	104316985	104316985	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcttatagttggaagatCtaaggcaaagactcaaggat	9	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:104316985C>A	ENST00000389120.3	+	15	2119	c.2029C>A	c.(2029-2031)Cta>Ata	p.L677I		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	677					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		GTTGGAAGATCTAAGGCAAAG	0.363													10	24					0.00829132	0.00855608	1	1	0	A	104316985	C	A	104316985	3	1	48	1	0	0	0	0	1	0	0	0	13524	912	32	2	2083	2	RNF20	9	104316985	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	616	104316985	36896446	2263	6657										
PPP3R2	5535	broad.mit.edu	37	chr9	104357195	104357195	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccgccgggtaactggcctcGtttcccattgtggacatctg	11	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:104357195G>A	ENST00000374806.1	-	1	88	c.18C>T	c.(16-18)aaC>aaT	p.N6N	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	3							calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AACTGGCCTCGTTTCCCATTG	0.592													36	53					0	0	1	0	0	A	104357195	G	A	104357195	2	1	48	1	0	0	0	0	0	0	0	1	12449	1136	40	1		1	PPP3R2	9	104357195	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40210	104357195	36856236	2264	6658										
OR13C4	138804	broad.mit.edu	37	chr9	107289097	107289097	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgttcatgatgatggggtAtctcagagggttacagatgg	14	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:107289097A>C	ENST00000277216.3	-	1	393	c.394T>G	c.(394-396)Tac>Gac	p.Y132D		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	132					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						ATGATGGGGTATCTCAGAGGG	0.453													20	97					0	0	1	0	0	C	107289097	A	C	107289097	3	2	48	1	0	0	0	0	1	0	0	0	10983	449	16	4	564	4	OR13C4	9	107289097	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2931902	107289097	33924334	2265	6659										
ABCA1	19	broad.mit.edu	37	chr9	107548664	107548664	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgcaaagagcttcacattCttccatactgcggtaaaaca	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:107548664C>A	ENST00000374736.3	-	48	6710	c.6316G>T	c.(6316-6318)Gaa>Taa	p.E2106*		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	2106	ABC transporter 2.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCTTCACATTCTTCCATACTG	0.413													21	44					7.41877e-09	8.8016e-09	1	1	0	A	107548664	C	A	107548664	4	1	48	1	0	0	0	0	0	1	0	0	28	922	32	2	481	2	ABCA1	9	107548664	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	259567	107548664	33664767	2266	6660										
ABCA1	19	broad.mit.edu	37	chr9	107595031	107595031	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgttcccaaaagtggtcatTgtccctgctgtccaacagca	8	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:107595031T>C	ENST00000374736.3	-	12	1727	c.1333A>G	c.(1333-1335)Aat>Gat	p.N445D		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	445					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAGTGGTCATTGTCCCTGCTG	0.453													19	50					0	0	1	0	0	C	107595031	T	C	107595031	3	2	48	1	0	0	0	0	1	0	0	0	28	1812	63	4	5608	4	ABCA1	9	107595031	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	46367	107595031	33618400	2267	6661										
ABCA1	19	broad.mit.edu	37	chr9	107620980	107620980	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtagccttgcaaaaatacCtggaagcatttcatgcaaag	9	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:107620980C>A	ENST00000374736.3	-	7	938		c.e7-1		ABCA1_ENST00000423487.2_Splice_Site	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1						Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCAAAAATACCTGGAAGCATT	0.393													25	39					2.48779e-11	3.09215e-11	1	1	0	A	107620980	C	A	107620980	5	1	48	1	0	0	0	0	0	0	1	0	28	695	24	5	6418	5	ABCA1	9	107620980	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	25949	107620980	33592451	2268	6662										
SLC44A1	23446	broad.mit.edu	37	chr9	108126842	108126842	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatattttcctaggcagtcCtgttcagaatgagcaaggct	10	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:108126842C>A	ENST00000374720.3	+	10	1341	c.1094C>A	c.(1093-1095)cCt>cAt	p.P365H	SLC44A1_ENST00000343170.7_Missense_Mutation_p.P157H|SLC44A1_ENST00000374723.1_Missense_Mutation_p.P365H|SLC44A1_ENST00000374724.1_Missense_Mutation_p.P365H	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	365						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	CTAGGCAGTCCTGTTCAGAAT	0.443													45	79					2.20914e-33	3.16969e-33	1	1	0	A	108126842	C	A	108126842	3	1	48	1	0	0	0	0	1	0	0	0	14689	681	24	5	1132	5	SLC44A1	9	108126842	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	505862	108126842	33086589	2269	6663										
TXN	7295	broad.mit.edu	37	chr9	113013138	113013138	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttcaaggaatatcacgtTggaatacttttcagagaggg	10	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:113013138T>C	ENST00000374517.5	-	3	355	c.151A>G	c.(151-153)Aac>Gac	p.N51D	TXN_ENST00000374515.5_Intron	NM_003329.3	NP_003320.2	P10599	THIO_HUMAN	thioredoxin	51	Thioredoxin.				cell proliferation|cell-cell signaling|cellular component movement|electron transport chain|glycerol ether metabolic process|nucleobase, nucleoside and nucleotide interconversion|positive regulation of DNA binding|regulation of protein import into nucleus, translocation|response to radiation|signal transduction|transcription, DNA-dependent|transport	cytosol|extracellular region|nucleoplasm	electron carrier activity|protein binding|protein disulfide oxidoreductase activity			kidney(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(323;7.36e-07)		AATATCACGTTGGAATACTTT	0.363													6	31					0	0	1	0	0	C	113013138	T	C	113013138	3	2	48	1	0	0	0	0	1	0	0	0	16851	1812	63	4	178	4	TXN	9	113013138	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4886296	113013138	28200293	2270	6664										
SVEP1	79987	broad.mit.edu	37	chr9	113275275	113275275	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgatgctgcttcccacaaGatcaaatccagggtgacatc	9	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:113275275G>T	ENST00000401783.2	-	5	1570	c.1234C>A	c.(1234-1236)Ctt>Att	p.L412I	SVEP1_ENST00000302728.8_Missense_Mutation_p.L412I|SVEP1_ENST00000374461.1_Missense_Mutation_p.L389I|SVEP1_ENST00000374469.1_Missense_Mutation_p.L389I|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	412	Sushi 1.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTTCCCACAAGATCAAATCCA	0.468													20	42					2.4624e-09	2.95225e-09	1	1	0	T	113275275	G	T	113275275	3	4	48	1	0	0	0	0	1	0	0	0	15475	942	33	2	9657	2	SVEP1	9	113275275	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	262137	113275275	27938156	2271	6665										
PTGR1	22949	broad.mit.edu	37	chr9	114355205	114355205	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggacaaatggaaataattaCttggccacttgctgccccat	9	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:114355205C>A	ENST00000407693.2	-	4	472		c.e4+1		PTGR1_ENST00000238248.3_Splice_Site|PTGR1_ENST00000538962.1_Splice_Site|PTGR1_ENST00000309195.5_Splice_Site	NM_001146108.1	NP_001139580.1	Q14914	PTGR1_HUMAN	prostaglandin reductase 1						leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)	11						GAAATAATTACTTGGCCACTT	0.383													9	32					3.86212e-05	4.21111e-05	1	1	0	A	114355205	C	A	114355205	5	1	48	1	0	0	0	0	0	0	1	0	12802	579	20	5	838	5	PTGR1	9	114355205	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1079930	114355205	26858226	2272	6666										
SUSD1	64420	broad.mit.edu	37	chr9	114864560	114864560	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccatcatcttctaagagatCaacttctaaaagacaagaga	5	9	5	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:114864560C>A	ENST00000374270.3	-	9	1349	c.1177G>T	c.(1177-1179)Gat>Tat	p.D393Y	SUSD1_ENST00000374264.2_Missense_Mutation_p.D393Y|SUSD1_ENST00000374263.3_Missense_Mutation_p.D393Y	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	393						integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TCTAAGAGATCAACTTCTAAA	0.358													7	14					0.00198382	0.00207034	1	1	0	A	114864560	C	A	114864560	3	1	48	1	0	0	0	0	1	0	0	0	15462	826	29	2	1102	2	SUSD1	9	114864560	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	509355	114864560	26348871	2273	6667										
HSDL2	84263	broad.mit.edu	37	chr9	115216318	115216318	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttccagaattcaaagaagaGaaactgcagctgcaaccaaa	8	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:115216318G>T	ENST00000398805.3	+	9	1118	c.891G>T	c.(889-891)gaG>gaT	p.E297D	HSDL2_ENST00000488101.1_3'UTR|HSDL2_ENST00000539114.1_Missense_Mutation_p.E92D|HSDL2_ENST00000398803.1_Missense_Mutation_p.E224D|HSDL2_ENST00000262542.7_Missense_Mutation_p.E177D	NM_032303.4	NP_115679.2	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	297						peroxisome	oxidoreductase activity|sterol binding			NS(1)|breast(2)|cervix(2)|endometrium(1)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	13						TCAAAGAAGAGAAACTGCAGC	0.398													20	39					2.94398e-08	3.45884e-08	1	1	0	T	115216318	G	T	115216318	3	4	48	1	0	0	0	0	1	0	0	0	7434	933	33	2	925	2	HSDL2	9	115216318	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	351758	115216318	25997113	2274	6668										
SLC46A2	57864	broad.mit.edu	37	chr9	115652731	115652731	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaggttgtagataatgtaGaaattggagatggctctctg	12	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:115652731G>T	ENST00000374228.4	-	1	462	c.231C>A	c.(229-231)ttC>ttA	p.F77L		NM_033051.3	NP_149040.3	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	77						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(1)	18						AGATAATGTAGAAATTGGAGA	0.607													10	120					1.76689e-08	2.08373e-08	1	1	0	T	115652731	G	T	115652731	3	4	48	1	0	0	0	0	1	0	0	0	14699	933	33	2	1212	2	SLC46A2	9	115652731	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	436413	115652731	25560700	2275	6669										
ZFP37	7539	broad.mit.edu	37	chr9	115805272	115805272	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcattacactcatacggtttCtctccagtatgaactctctg	5	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:115805272C>A	ENST00000374227.3	-	4	1653	c.1626G>T	c.(1624-1626)gaG>gaT	p.E542D	ZFP37_ENST00000553380.1_Missense_Mutation_p.E557D|ZFP37_ENST00000555206.1_Missense_Mutation_p.E543D			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	542						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CATACGGTTTCTCTCCAGTAT	0.398													18	30					1.02788e-11	1.28326e-11	1	1	0	A	115805272	C	A	115805272	3	1	48	1	0	0	0	0	1	0	0	0	17705	912	32	2	270	2	ZFP37	9	115805272	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	152541	115805272	25408159	2276	6670										
C9orf43	257169	broad.mit.edu	37	chr9	116187312	116187312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccagagaccagcactgcGatatcctgaacgtttgaaga	9	11	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:116187312G>A	ENST00000288462.4	+	9	1267	c.821G>A	c.(820-822)cGa>cAa	p.R274Q	C9orf43_ENST00000374165.1_Missense_Mutation_p.R274Q	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	274										breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						CCAGCACTGCGATATCCTGAA	0.408													15	18					0	0	1	0	0	A	116187312	G	A	116187312	3	1	48	1	0	0	0	0	1	0	0	0	2501	1058	37	1	851	1	C9orf43	9	116187312	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	382040	116187312	25026119	2277	6671										
C9orf43	257169	broad.mit.edu	37	chr9	116187673	116187673	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcagcagcagcaacagaaGaaggtgaaaacacctattaa	9	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:116187673G>A	ENST00000288462.4	+	10	1361	c.915G>A	c.(913-915)aaG>aaA	p.K305K	C9orf43_ENST00000374165.1_Silent_p.K305K	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	305								p.K305N(1)		breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						agcaacagAAGAAGGTGAAAA	0.542													19	48					0	0	1	0	0	A	116187673	G	A	116187673	2	1	48	1	0	0	0	0	0	0	0	1	2501	933	33	3		3	C9orf43	9	116187673	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	361	116187673	25025758	2278	6672										
RGS3	5998	broad.mit.edu	37	chr9	116346160	116346160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgcctcctagccaggtctCcctgccagccaaggccctta	8	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:116346160C>T	ENST00000374140.2	+	21	2677	c.2468C>T	c.(2467-2469)tCc>tTc	p.S823F	RGS3_ENST00000374134.3_Missense_Mutation_p.S144F|RGS3_ENST00000394646.3_Intron|RGS3_ENST00000462143.1_Missense_Mutation_p.S144F|RP11-168K11.2_ENST00000428429.1_RNA|RGS3_ENST00000350696.5_Missense_Mutation_p.S823F|RGS3_ENST00000342620.5_Intron|RGS3_ENST00000343817.5_Missense_Mutation_p.S542F	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	823					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						AGCCAGGTCTCCCTGCCAGCC	0.637													64	129					0	0	1	0	0	T	116346160	C	T	116346160	3	4	48	1	0	0	0	0	1	0	0	0	13355	855	30	3	2799	3	RGS3	9	116346160	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	158487	116346160	24867271	2279	6673										
COL27A1	85301	broad.mit.edu	37	chr9	117027726	117027726	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccgggtccctcaggccccCcaggcaccaagggcctccca	10	21	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:117027726C>A	ENST00000356083.3	+	32	3755	c.3364C>A	c.(3364-3366)Cca>Aca	p.P1122T		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1122	Collagen-like 8.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CTCAGGCCCCCCAGGCACCAA	0.612													4	35					0.184627	0.185817	1	1	0	A	117027726	C	A	117027726	3	1	48	1	0	0	0	0	1	0	0	0	3708	623	22	5	3490	5	COL27A1	9	117027726	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	681566	117027726	24185705	2280	6674										
TNC	3371	broad.mit.edu	37	chr9	117845063	117845063	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccttgatggacttgaattTcaggccttcaggtgcaggta	11	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:117845063T>C	ENST00000350763.4	-	5	2566	c.2155A>G	c.(2155-2157)Aaa>Gaa	p.K719E	TNC_ENST00000535648.1_Missense_Mutation_p.K719E|TNC_ENST00000423613.2_Missense_Mutation_p.K719E|TNC_ENST00000346706.3_Missense_Mutation_p.K719E|TNC_ENST00000345230.3_Missense_Mutation_p.K719E|TNC_ENST00000542877.1_Missense_Mutation_p.K719E|TNC_ENST00000340094.3_Missense_Mutation_p.K719E|TNC_ENST00000341037.4_Missense_Mutation_p.K719E|TNC_ENST00000537320.1_Missense_Mutation_p.K719E	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	719	Fibronectin type-III 2.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GACTTGAATTTCAGGCCTTCA	0.463													19	30					0	0	1	0	0	C	117845063	T	C	117845063	3	2	48	1	0	0	0	0	1	0	0	0	16329	1792	62	4	4546	4	TNC	9	117845063	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	817337	117845063	23368368	2281	6675										
PAPPA	5069	broad.mit.edu	37	chr9	118969875	118969875	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacaaggaggccctgatgcActtaggtgagtcttagaaac	13	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:118969875A>G	ENST00000328252.3	+	3	1988	c.1619A>G	c.(1618-1620)cAc>cGc	p.H540R	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	540	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GCCCTGATGCACTTAGGTGAG	0.453													10	29					0	0	1	0	0	G	118969875	A	G	118969875	3	3	48	1	0	0	0	0	1	0	0	0	11478	159	6	4	1629	4	PAPPA	9	118969875	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1124812	118969875	22243556	2282	6676										
TLR4	7099	broad.mit.edu	37	chr9	120475079	120475079	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaaccaggtgcatttaaaGaaattaggcttcataagctg	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:120475079G>T	ENST00000355622.6	+	3	774	c.673G>T	c.(673-675)Gaa>Taa	p.E225*	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Nonsense_Mutation_p.E185*	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	225					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TGCATTTAAAGAAATTAGGCT	0.373													12	45					0.00185496	0.00194308	1	1	0	T	120475079	G	T	120475079	4	4	48	1	0	0	0	0	0	1	0	0	16012	943	33	2	683	2	TLR4	9	120475079	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1505204	120475079	20738352	2283	6677										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123201969	123201969	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcccacacaaaactgtaaTtatggcctcactgcactggg	8	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:123201969T>G	ENST00000349780.4	-	24	3609	c.3430A>C	c.(3430-3432)Att>Ctt	p.I1144L	CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.I1144L|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.I1103L|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.I1112L	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1144	Interaction with MAPRE1.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						AAAACTGTAATTATGGCCTCA	0.443											OREG0019438	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	37					0	0	1	0	0	G	123201969	T	G	123201969	3	3	48	1	0	0	0	0	1	0	0	0	3168	1493	52	4	2311	4	CDK5RAP2	9	123201969	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2726890	123201969	18011462	2284	6678										
MEGF9	1955	broad.mit.edu	37	chr9	123367548	123367548	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgccatcatcttccaacaAtcccgaaacatctgcattgg	5	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:123367548A>C	ENST00000373930.3	-	6	1840	c.1729T>G	c.(1729-1731)Ttg>Gtg	p.L577V	MEGF9_ENST00000426959.1_Missense_Mutation_p.L614V	NM_001080497.2	NP_001073966.2	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	577						integral to membrane	calcium ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	16						TCTTCCAACAATCCCGAAACA	0.483													44	75					0	0	1	0	0	C	123367548	A	C	123367548	3	2	48	1	0	0	0	0	1	0	0	0	9513	98	4	4	83	4	MEGF9	9	123367548	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	165579	123367548	17845883	2285	6679										
PHF19	26147	broad.mit.edu	37	chr9	123620323	123620323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctccccacaggccaaccGcccagctgcaccaaagtagt	7	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:123620323G>A	ENST00000373896.3	-	15	1894	c.1642C>T	c.(1642-1644)Cgg>Tgg	p.R548W	PHF19_ENST00000487555.1_5'UTR|PHF19_ENST00000419155.1_Missense_Mutation_p.R339W	NM_015651.1	NP_056466.1	Q5T6S3	PHF19_HUMAN	PHD finger protein 19	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAGGCCAACCGCCCAGCTGCA	0.557													36	45					0	0	1	0	0	A	123620323	G	A	123620323	3	1	48	1	0	0	0	0	1	0	0	0	11876	1086	38	1	104	1	PHF19	9	123620323	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	252775	123620323	17593108	2286	6680										
GSN	2934	broad.mit.edu	37	chr9	124062336	124062336	+	Translation_Start_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaactctctattgtaagttCttgcagatacagcgctagga	9	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:124062336C>A	ENST00000436847.1	+	0	214				GSN_ENST00000373808.2_Intron|GSN_ENST00000341272.2_Intron|GSN_ENST00000449733.1_Intron|GSN_ENST00000394353.2_Intron|GSN_ENST00000412819.1_Intron|GSN_ENST00000373818.4_Intron|GSN_ENST00000545652.1_Intron|GSN_ENST00000373823.3_Intron	NM_001127666.1	NP_001121138.1	P06396	GELS_HUMAN	gelsolin						actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						ATTGTAAGTTCTTGCAGATAC	0.607													23	50					7.87624e-14	1.01695e-13	1	1	0	A	124062336	C	A	124062336	1	1	48	1	0	0	0	0	0	0	0	0	6865	928	32	2		2	GSN	9	124062336	Translation_Start_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	442013	124062336	17151095	2287	6681										
OR1J1	347168	broad.mit.edu	37	chr9	125239745	125239745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtatgcaaaagagcacacGcacaagcgatgacccaggac	12	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:125239745G>A	ENST00000259357.2	-	1	490	c.461C>T	c.(460-462)gCg>gTg	p.A154V		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						AAGAGCACACGCACAAGCGAT	0.542													18	28					0	0	1	0	0	A	125239745	G	A	125239745	3	1	48	1	0	0	0	0	1	0	0	0	11006	1087	38	1	510	1	OR1J1	9	125239745	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1177409	125239745	15973686	2288	6682										
OR1L4	254973	broad.mit.edu	37	chr9	125486805	125486805	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatcattaagcactttttCtgtgacacccagcctgtgct	6	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:125486805C>A	ENST00000259466.1	+	1	537	c.537C>A	c.(535-537)ttC>ttA	p.F179L		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						AGCACTTTTTCTGTGACACCC	0.507													74	227					1.70349e-48	2.47193e-48	1	1	0	A	125486805	C	A	125486805	3	1	48	1	0	0	0	0	1	0	0	0	11012	912	32	2	539	2	OR1L4	9	125486805	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	247060	125486805	15726626	2289	6683										
OR5C1	392391	broad.mit.edu	37	chr9	125551852	125551852	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcttcatccagacagccaCggtgttagctatcacggtgt	11	11	2	1	rs112939157		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:125551852C>T	ENST00000373680.2	+	1	703	c.641C>T	c.(640-642)aCg>aTg	p.T214M		NM_001001923.1	NP_001001923.1	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C, member 1	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(5)|skin(1)	20						CAGACAGCCACGGTGTTAGCT	0.577													22	36					0	0	1	0	0	T	125551852	C	T	125551852	3	4	48	1	0	0	0	0	1	0	0	0	11199	536	19	1	643	1	OR5C1	9	125551852	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	65047	125551852	15661579	2290	6684										
PDCL	5082	broad.mit.edu	37	chr9	125585323	125585323	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatcttctcctggaggtctTtctgtttctgttgctcctcc	8	12	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:125585323T>C	ENST00000259467.4	-	3	491	c.326A>G	c.(325-327)aAa>aGa	p.K109R		NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like	109					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						CTGGAGGTCTTTCTGTTTCTG	0.507													58	87					0	0	1	0	0	C	125585323	T	C	125585323	3	2	48	1	0	0	0	0	1	0	0	0	11672	1841	64	4	587	4	PDCL	9	125585323	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	33471	125585323	15628108	2291	6685										
ZBTB26	57684	broad.mit.edu	37	chr9	125682120	125682120	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaactgtaacatcacaaaAtttattctcttctcttaatt	3	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:125682120A>C	ENST00000373656.3	-	2	167	c.94T>G	c.(94-96)Ttt>Gtt	p.F32V	ZBTB26_ENST00000373654.1_Missense_Mutation_p.F32V	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						ACATCACAAAATTTATTCTCT	0.328													10	15					0	0	1	0	0	C	125682120	A	C	125682120	3	2	48	1	0	0	0	0	1	0	0	0	17591	101	4	4	1235	4	ZBTB26	9	125682120	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	96797	125682120	15531311	2292	6686										
NR6A1	2649	broad.mit.edu	37	chr9	127302467	127302467	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgatttcttcttccgatatCtttgacaaggaattgagaca	7	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:127302467C>A	ENST00000487099.2	-	5	599		c.e5-1		NR6A1_ENST00000373584.3_Splice_Site|NR6A1_ENST00000344523.4_Splice_Site|NR6A1_ENST00000416460.2_Splice_Site	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1						cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						CTTCCGATATCTTTGACAAGG	0.453													34	66					1.36161e-19	1.85609e-19	1	1	0	A	127302467	C	A	127302467	5	1	48	1	0	0	0	0	0	0	1	0	10684	927	32	2	1025	2	NR6A1	9	127302467	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1620347	127302467	13910964	2293	6687										
PBX3	5090	broad.mit.edu	37	chr9	128692040	128692040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggtgggcatcatccatcGaaaatttagttccattcaga	8	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:128692040G>A	ENST00000373487.4	+	4	703	c.623G>A	c.(622-624)cGa>cAa	p.R208Q	PBX3_ENST00000447726.2_Missense_Mutation_p.R133Q|PBX3_ENST00000538998.1_3'UTR|PBX3_ENST00000373483.2_Missense_Mutation_p.R27Q|PBX3_ENST00000373489.5_Missense_Mutation_p.R208Q|PBX3_ENST00000342287.5_Missense_Mutation_p.R208Q			P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3	208					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			biliary_tract(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)	24						ATCATCCATCGAAAATTTAGT	0.393													9	85					0	0	1	0	0	A	128692040	G	A	128692040	3	1	48	1	0	0	0	0	1	0	0	0	11540	1058	37	1	637	1	PBX3	9	128692040	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1389573	128692040	12521391	2294	6688										
LMX1B	4010	broad.mit.edu	37	chr9	129453169	129453169	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagatcgcccccaccgagttCgtgatgcgggcgctggagtg	15	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:129453169C>T	ENST00000355497.5	+	3	388	c.381C>T	c.(379-381)ttC>ttT	p.F127F	LMX1B_ENST00000373474.4_Silent_p.F127F|LMX1B_ENST00000561065.1_Silent_p.F104F|LMX1B_ENST00000425646.2_Silent_p.F104F|LMX1B_ENST00000526117.1_Silent_p.F127F	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	104	LIM zinc-binding 2.				dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						CCACCGAGTTCGTGATGCGGG	0.637									Nail-Patella Syndrome				16	23					0	0	1	0	0	T	129453169	C	T	129453169	2	4	48	1	0	0	0	0	0	0	0	1	8902	883	31	1		1	LMX1B	9	129453169	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	761129	129453169	11760262	2295	6689										
GLE1	2733	broad.mit.edu	37	chr9	131302553	131302553	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgtctttctctccctgtaGaattgaagctatcacaagct	7	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:131302553G>T	ENST00000309971.4	+	15	2070		c.e15-1		RP11-216B9.6_ENST00000434999.1_RNA|GLE1_ENST00000539582.1_Splice_Site	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator						poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						TCTCCCTGTAGAATTGAAGCT	0.493													9	28					1.12685e-05	1.24509e-05	1	1	0	T	131302553	G	T	131302553	5	4	48	1	0	0	0	0	0	0	1	0	6476	956	33	2	2038	2	GLE1	9	131302553	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1849384	131302553	9910878	2296	6690										
IER5L	389792	broad.mit.edu	37	chr9	131939486	131939486	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgccctggccacagcagggGcagtgggcggaggcgcagca	19	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:131939486G>A	ENST00000372491.2	-	1	1054	c.846C>T	c.(844-846)tgC>tgT	p.C282C	RP11-247A12.2_ENST00000372490.3_RNA|RP11-247A12.8_ENST00000599172.2_RNA	NM_203434.2	NP_982258.2	Q5T953	IER5L_HUMAN	immediate early response 5-like	282													Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		CACAGCAGGGGCAGTGGGCGG	0.682													6	18					0	0	1	0	0	A	131939486	G	A	131939486	2	1	48	1	0	0	0	0	0	0	0	1	7552	1195	42	3		3	IER5L	9	131939486	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	636933	131939486	9273945	2297	6691										
ASB6	140459	broad.mit.edu	37	chr9	132400459	132400459	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaccagcaggacgcaccGtgcagggagcagttgtaggc	15	12	0	1	rs113686617	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:132400459G>T	ENST00000277458.4	-	6	1041	c.876C>A	c.(874-876)caC>caA	p.H292Q	ASB6_ENST00000277459.4_3'UTR|ASB6_ENST00000450050.2_Missense_Mutation_p.H213Q	NM_017873.3	NP_060343.1	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box containing 6	292					intracellular signal transduction	cytoplasm				NS(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	15		Ovarian(14;0.00556)				AGGACGCACCGTGCAGGGAGC	0.597													30	40					3.73988e-18	5.05028e-18	1	1	0	T	132400459	G	T	132400459	3	4	48	1	0	0	0	0	1	0	0	0	1026	1136	40	5	393	5	ASB6	9	132400459	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	460973	132400459	8812972	2298	6692										
ABL1	25	broad.mit.edu	37	chr9	133748273	133748273	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacccgggagcccccgttcTatatcatcactgagttcatg	9	14	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:133748273T>C	ENST00000318560.5	+	6	1315	c.934T>C	c.(934-936)Tat>Cat	p.Y312H		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	312	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GCCCCCGTTCTATATCATCAC	0.557			"T, Mis"	"BCR, ETV6, NUP214"	"CML, ALL, T-ALL"								17	70					0	0	1	0	0	C	133748273	T	C	133748273	3	2	48	1	0	0	0	0	1	0	0	0	92	1522	53	4	1096	4	ABL1	9	133748273	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1347814	133748273	7465158	2299	6693										
FIBCD1	84929	broad.mit.edu	37	chr9	133787197	133787197	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctagccagtgctccccggTgagcctgccaaagccgtctc	10	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:133787197T>C	ENST00000372338.4	-	5	1170	c.928A>G	c.(928-930)Acc>Gcc	p.T310A	FIBCD1_ENST00000372337.2_Missense_Mutation_p.T152A|FIBCD1_ENST00000253018.4_Missense_Mutation_p.T152A|FIBCD1_ENST00000448616.1_Missense_Mutation_p.T310A	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	310	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		TGCTCCCCGGTGAGCCTGCCA	0.667													5	9					0	0	1	0	0	C	133787197	T	C	133787197	3	2	48	1	0	0	0	0	1	0	0	0	5916	1696	59	4	469	4	FIBCD1	9	133787197	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	38924	133787197	7426234	2300	6694										
LAMC3	10319	broad.mit.edu	37	chr9	133928021	133928021	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctgaggcactctagcctgTctggcccccaggatgccggg	13	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:133928021T>C	ENST00000361069.4	+	10	1907	c.1774T>C	c.(1774-1776)Tct>Cct	p.S592P	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	592	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTCTAGCCTGTCTGGCCCCCA	0.637											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	42					0	0	1	0	0	C	133928021	T	C	133928021	3	2	48	1	0	0	0	0	1	0	0	0	8654	1667	58	4	1812	4	LAMC3	9	133928021	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	140824	133928021	7285410	2301	6695										
TTF1	7270	broad.mit.edu	37	chr9	135277008	135277008	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaatcatcaccagacactcGtgcccttttgacagacgtaa	6	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:135277008G>A	ENST00000334270.2	-	2	1240	c.1201C>T	c.(1201-1203)Cga>Tga	p.R401*		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	401			R -> Q (in dbSNP:rs3739916).		negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCAGACACTCGTGCCCTTTTG	0.453													29	72					0	0	1	0	0	A	135277008	G	A	135277008	4	1	48	1	0	0	0	0	0	1	0	0	16779	1153	40	1	1556	1	TTF1	9	135277008	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1348987	135277008	5936423	2302	6696										
TSC1	0	broad.mit.edu	37	chr9	135796771	135796771	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgagggtccagttcatggTccttggatccagtcactaat	10	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:135796771T>C	ENST00000298552.3	-	8	937	c.716A>G	c.(715-717)gAc>gGc	p.D239G	TSC1_ENST00000545250.1_Missense_Mutation_p.D188G|TSC1_ENST00000440111.2_Missense_Mutation_p.D239G|TSC1_ENST00000403810.1_Missense_Mutation_p.D239G	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	239					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CAGTTCATGGTCCTTGGATCC	0.408			"D, Mis, N, F, S"			"hamartoma, renal cell"			Tuberous Sclerosis				16	22					0	0	1	0	0	C	135796771	T	C	135796771	3	2	48	1	0	0	0	0	1	0	0	0	16665	1667	58	4	2842	4	TSC1	9	135796771	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	519763	135796771	5416660	2303	6697										
RALGDS	5900	broad.mit.edu	37	chr9	135983592	135983592	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagagctggcgctggagccGattctagtcccacagctggc	13	14	1	1	rs151046197		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:135983592G>A	ENST00000393160.3	-	6	1168	c.815C>T	c.(814-816)tCg>tTg	p.S272L	RALGDS_ENST00000372062.3_Missense_Mutation_p.S298L|RALGDS_ENST00000542690.1_Missense_Mutation_p.S398L|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000372050.3_Missense_Mutation_p.S327L|RALGDS_ENST00000372047.3_Missense_Mutation_p.S315L|RALGDS_ENST00000393157.3_Missense_Mutation_p.S326L	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	327					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CGCTGGAGCCGATTCTAGTCC	0.597			T	CIITA	"PMBL, Hodgkin Lymphona, "								20	19					0	0	1	0	0	A	135983592	G	A	135983592	3	1	48	1	0	0	0	0	1	0	0	0	13067	1059	37	1	1816	1	RALGDS	9	135983592	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	186821	135983592	5229839	2304	6698										
ABO	28	broad.mit.edu	37	chr9	136135231	136135231	+	RNA	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgacattataccttggcaaCgagacatgctgcagatggtc	10	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:136135231C>T	ENST00000453660.2	-	0	206							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		ACCTTGGCAACGAGACATGCT	0.517													11	70					0	0	1	0	0	T	136135231	C	T	136135231	1	4	48	0	1	0	0	0	0	0	0	0	97	523	19	1		1	ABO	9	136135231	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	151639	136135231	5078200	2305	6699										
C9orf96	169436	broad.mit.edu	37	chr9	136268898	136268898	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttggccacctaccctgcgGatggggaaatggcagaagcc	14	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:136268898G>T	ENST00000371957.3	+	15	1656	c.1549G>T	c.(1549-1551)Gat>Tat	p.D517Y	C9orf96_ENST00000371955.1_Missense_Mutation_p.D50Y	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	517							ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTACCCTGCGGATGGGGAAAT	0.652													10	22					0.00621372	0.0064192	1	1	0	T	136268898	G	T	136268898	3	4	48	1	0	0	0	0	1	0	0	0	2526	1174	41	2	1607	2	C9orf96	9	136268898	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	133667	136268898	4944533	2306	6700										
DBH	1621	broad.mit.edu	37	chr9	136507486	136507486	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagacgcgtgcaccatggAggtccaagctcccaatatcc	9	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:136507486A>C	ENST00000393056.2	+	3	656	c.644A>C	c.(643-645)gAg>gCg	p.E215A		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	215					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TGCACCATGGAGGTCCAAGCT	0.587													17	35					0	0	1	0	0	C	136507486	A	C	136507486	3	2	48	1	0	0	0	0	1	0	0	0	4274	304	11	4	654	4	DBH	9	136507486	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	238588	136507486	4705945	2307	6701										
OBP2A	29991	broad.mit.edu	37	chr9	138440590	138440590	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacctggaggccctggaagAatttaagaaattggtgcagc	12	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:138440590A>C	ENST00000539850.1	+	5	451	c.425A>C	c.(424-426)gAa>gCa	p.E142A	OBP2A_ENST00000340780.3_Missense_Mutation_p.N164H|OBP2A_ENST00000342114.4_Missense_Mutation_p.E119A|OBP2A_ENST00000371776.1_Missense_Mutation_p.E142A			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	142					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GCCCTGGAAGAATTTAAGAAA	0.597													34	66					0	0	1	0	0	C	138440590	A	C	138440590	3	2	48	1	0	0	0	0	1	0	0	0	10857	246	9	4	443	4	OBP2A	9	138440590	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1933104	138440590	2772841	2308	6702										
LCN9	392399	broad.mit.edu	37	chr9	138556129	138556129	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaacggcagcctaatatTtgatttcgaatacatgtgcg	10	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:138556129T>C	ENST00000277526.3	+	2	218	c.218T>C	c.(217-219)tTt>tCt	p.F73S	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	73						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		AGCCTAATATTTGATTTCGAA	0.488													44	60					0	0	1	0	0	C	138556129	T	C	138556129	3	2	48	1	0	0	0	0	1	0	0	0	8725	1841	64	4	224	4	LCN9	9	138556129	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	115539	138556129	2657302	2309	6703										
KCNT1	57582	broad.mit.edu	37	chr9	138656879	138656879	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtttctcacctgcagttCgaggagctcgtctacctctg	9	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:138656879C>T	ENST00000298480.5	+	12	1112	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	KCNT1_ENST00000490355.2_Silent_p.F327F|KCNT1_ENST00000487664.1_Silent_p.F301F|KCNT1_ENST00000263604.3_Silent_p.F327F|KCNT1_ENST00000486577.2_Silent_p.F307F|KCNT1_ENST00000488444.2_Silent_p.F327F|KCNT1_ENST00000491806.2_Silent_p.F313F|KCNT1_ENST00000371757.2_Silent_p.F346F			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	346						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		ACCTGCAGTTCGAGGAGCTCG	0.632													10	17					0	0	1	0	0	T	138656879	C	T	138656879	2	4	48	1	0	0	0	0	0	0	0	1	8134	883	31	1		1	KCNT1	9	138656879	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	100750	138656879	2556552	2310	6704										
CAMSAP1	157922	broad.mit.edu	37	chr9	138709842	138709842	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgctgagagggtgtgccccCggaatgaacgctctcgggtt	15	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:138709842C>T	ENST00000389532.4	-	14	4316	c.4252G>A	c.(4252-4254)Ggg>Agg	p.G1418R	CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.G1429R|CAMSAP1_ENST00000312405.6_Missense_Mutation_p.G1140R	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1418						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GGTGTGCCCCCGGAATGAACG	0.637													14	20					0	0	1	0	0	T	138709842	C	T	138709842	3	4	48	1	0	0	0	0	1	0	0	0	2629	652	23	1	572	1	CAMSAP1	9	138709842	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	52963	138709842	2503589	2311	6705										
CAMSAP1	157922	broad.mit.edu	37	chr9	138742171	138742171	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaataattcgttattaccttCaacactaatggcgcatacag	5	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:138742171C>A	ENST00000389532.4	-	6	1009	c.945G>T	c.(943-945)ttG>ttT	p.L315F	CAMSAP1_ENST00000409386.3_Missense_Mutation_p.L326F|CAMSAP1_ENST00000312405.6_Missense_Mutation_p.L37F	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	315	CH.					cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		TTATTACCTTCAACACTAATG	0.323													34	51					2.42023e-17	3.24332e-17	1	1	0	A	138742171	C	A	138742171	3	1	48	1	0	0	0	0	1	0	0	0	2629	825	29	2	3911	2	CAMSAP1	9	138742171	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32329	138742171	2471260	2312	6706										
ANAPC2	29882	broad.mit.edu	37	chr9	140082342	140082342	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggccaaaagcgtcaaggaGtagcaaaaggcactggggct	14	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:140082342G>A	ENST00000323927.2	-	2	335	c.331C>T	c.(331-333)Ctc>Ttc	p.L111F		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	111					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GCGTCAAGGAGTAGCAAAAGG	0.587													33	80					0	0	1	0	0	A	140082342	G	A	140082342	3	1	48	1	0	0	0	0	1	0	0	0	599	1029	36	3	2185	3	ANAPC2	9	140082342	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1340171	140082342	1131089	2313	6707										
TPRN	286262	broad.mit.edu	37	chr9	140093883	140093883	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagcaggctcagcttcttcCgaagcagccggcaggaaggg	14	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:140093883C>T	ENST00000409012.4	-	1	1367	c.1281G>A	c.(1279-1281)tcG>tcA	p.S427S	TPRN_ENST00000541945.1_Intron|TPRN_ENST00000321773.2_Silent_p.S366S	NM_001128228.2	NP_001121700.2	Q4KMQ1	TPRN_HUMAN	taperin	427					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						CAGCTTCTTCCGAAGCAGCCG	0.657													8	22					0	0	1	0	0	T	140093883	C	T	140093883	2	4	48	1	0	0	0	0	0	0	0	1	16481	639	23	1		1	TPRN	9	140093883	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11541	140093883	1119548	2314	6708										
PNPLA7	375775	broad.mit.edu	37	chr9	140354851	140354851	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttagcagaggcctctacccGtcctggtcagaggagccctc	11	14	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:140354851G>A	ENST00000406427.1	-	35	4359	c.4023C>T	c.(4021-4023)gaC>gaT	p.D1341D	PNPLA7_ENST00000371457.1_Silent_p.D922D|PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000277531.4_Silent_p.D1316D	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1316					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GCCTCTACCCGTCCTGGTCAG	0.617													8	32					0	0	1	0	0	A	140354851	G	A	140354851	2	1	48	1	0	0	0	0	0	0	0	1	12217	1136	40	1		1	PNPLA7	9	140354851	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	260968	140354851	858580	2315	6709										
PNPLA7	375775	broad.mit.edu	37	chr9	140400121	140400121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctctgaagatggcatccGacttcctgctggccagggtc	12	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:140400121G>A	ENST00000406427.1	-	14	1754	c.1418C>T	c.(1417-1419)tCg>tTg	p.S473L	PNPLA7_ENST00000371457.1_Missense_Mutation_p.S54L|PNPLA7_ENST00000277531.4_Missense_Mutation_p.S448L	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	448				FLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETL ASRKSDAIFRAAKKDLLTLMKLEDSSLLDG -> LCLLPQC LGGLPPTDTSVYSSASSDCCGCSMPVLCIMGHKPHVTVDT (in Ref. 1; BAC86509).	lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GATGGCATCCGACTTCCTGCT	0.612													48	85					0	0	1	0	0	A	140400121	G	A	140400121	3	1	48	1	0	0	0	0	1	0	0	0	12217	1059	37	1	2698	1	PNPLA7	9	140400121	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	45270	140400121	813310	2316	6710										
EHMT1	79813	broad.mit.edu	37	chr9	140646849	140646849	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaggaggaaggcggtgacGagtctgacctggtaatgccc	17	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:140646849G>A	ENST00000460843.1	+	7	1264	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	EHMT1_ENST00000371394.2_3'UTR|EHMT1_ENST00000462484.1_Missense_Mutation_p.E413K|EHMT1_ENST00000334856.6_Missense_Mutation_p.E382K	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	413					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		AGGCGGTGACGAGTCTGACCT	0.592													11	20					0	0	1	0	0	A	140646849	G	A	140646849	3	1	48	1	0	0	0	0	1	0	0	0	5009	1059	37	1	1263	1	EHMT1	9	140646849	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	246728	140646849	566582	2317	6711										
CACNA1B	774	broad.mit.edu	37	chr9	140851266	140851266	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaggaatgcagaggagaaGtcccctttggacggtaggtg	16	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:140851266G>A	ENST00000371372.1	+	9	1375	c.1230G>A	c.(1228-1230)aaG>aaA	p.K410K	CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371363.1_Silent_p.K410K|CACNA1B_ENST00000277551.2_Silent_p.K410K|CACNA1B_ENST00000371355.4_Silent_p.K410K|CACNA1B_ENST00000371357.1_Silent_p.K410K	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	410					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CAGAGGAGAAGTCCCCTTTGG	0.612													26	47					0	0	1	0	0	A	140851266	G	A	140851266	2	1	48	1	0	0	0	0	0	0	0	1	2557	1020	36	3		3	CACNA1B	9	140851266	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	204417	140851266	362165	2318	6712										
CACNA1B	774	broad.mit.edu	37	chr9	141008837	141008837	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttcttttccagctgatgaGatgacagtggggaaggttta	13	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr9:141008837G>T	ENST00000277549.5	+	41	5695	c.3126G>T	c.(3124-3126)gaG>gaT	p.E1042D	CACNA1B_ENST00000371372.1_Missense_Mutation_p.E1848D|CACNA1B_ENST00000371363.1_Missense_Mutation_p.E1846D|CACNA1B_ENST00000277551.2_Missense_Mutation_p.E1848D|CACNA1B_ENST00000371355.4_Missense_Mutation_p.E1849D|CACNA1B_ENST00000371357.1_Missense_Mutation_p.E1847D			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1848					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CAGCTGATGAGATGACAGTGG	0.512													5	5					4.096e-09	4.90247e-09	1	1	0	T	141008837	G	T	141008837	3	4	48	1	0	0	0	0	1	0	0	0	2557	933	33	2	5702	2	CACNA1B	9	141008837	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	157571	141008837	204594	2319	6713										
ZMYND11	10771	broad.mit.edu	37	chr10	288047	288047	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaaagaagacaatcaagtCgacgttcgcttctttggcca	9	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:288047C>T	ENST00000397962.3	+	10	1346	c.918C>T	c.(916-918)gtC>gtT	p.V306V	ZMYND11_ENST00000558098.2_Silent_p.V306V|ZMYND11_ENST00000397959.3_Silent_p.V221V|ZMYND11_ENST00000381584.1_Silent_p.V289V|ZMYND11_ENST00000545619.1_Silent_p.V186V|ZMYND11_ENST00000381602.4_Silent_p.V266V|ZMYND11_ENST00000602682.1_Silent_p.V221V|ZMYND11_ENST00000381604.4_Silent_p.V266V|ZMYND11_ENST00000403354.1_Silent_p.V226V|ZMYND11_ENST00000309776.4_Silent_p.V266V|ZMYND11_ENST00000535374.1_Silent_p.V101V|ZMYND11_ENST00000509513.2_Silent_p.V305V|ZMYND11_ENST00000402736.1_Silent_p.V275V|ZMYND11_ENST00000381607.4_Silent_p.V212V|ZMYND11_ENST00000381591.1_Silent_p.V306V			Q15326	ZMY11_HUMAN	zinc finger, MYND-type containing 11	266					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	24		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		ACAATCAAGTCGACGTTCGCT	0.428													5	70					0	0	1	0	0	T	288047	C	T	288047	2	4	48	1	0	0	0	0	0	0	0	1	17763	871	31	1		1	ZMYND11	10	288047	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		288047	135246700	2320	6714										
LARP4B	23185	broad.mit.edu	37	chr10	876893	876893	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tataaattttggtaaattatCtcctttaaatagtgcttcta	4	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:876893C>A	ENST00000316157.3	-	8	815	c.775G>T	c.(775-777)Gat>Tat	p.D259Y		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	259	RRM.						nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						GGTAAATTATCTCCTTTAAAT	0.284													18	33					2.35188e-11	2.92451e-11	1	1	0	A	876893	C	A	876893	3	1	48	1	0	0	0	0	1	0	0	0	8669	913	32	2	1481	2	LARP4B	10	876893	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	588846	876893	134657854	2321	6715										
ADARB2	105	broad.mit.edu	37	chr10	1405395	1405395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatcacgaagctccgcgcgCgccgctcggccggttctgcc	12	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:1405395C>T	ENST00000381312.1	-	3	1230	c.905G>A	c.(904-906)cGc>cAc	p.R302H		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	302	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCTCCGCGCGCGCCGCTCGGC	0.761													3	10					0	0	1	0	0	T	1405395	C	T	1405395	3	4	48	1	0	0	0	0	1	0	0	0	282	768	27	1	1346	1	ADARB2	10	1405395	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	528502	1405395	134129352	2322	6716										
AKR1C1	1645	broad.mit.edu	37	chr10	5006036	5006036	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttgtatagtcgaacagaTatttacttcttccaagaaga	6	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:5006036T>C	ENST00000380859.1	+	1	56	c.41T>C	c.(40-42)aTa>aCa	p.I14T	AKR1C1_ENST00000434459.2_Intron|AKR1C1_ENST00000380872.4_Intron|AKR1C1_ENST00000477661.1_Intron					aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						GTCGAACAGATATTTACTTCT	0.413													9	50					0	0	1	0	0	C	5006036	T	C	5006036	3	2	48	1	0	0	0	0	1	0	0	0	466	1421	49	4		4	AKR1C1	10	5006036	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3600641	5006036	130528711	2323	6717										
UCN3	114131	broad.mit.edu	37	chr10	5416147	5416147	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgccaatgcccacctgatggCgcaaattgggaggaagaagt	13	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:5416147C>T	ENST00000380433.3	+	2	692	c.464C>T	c.(463-465)gCg>gTg	p.A155V		NM_053049.2	NP_444277.2	Q969E3	UCN3_HUMAN	urocortin 3	155						extracellular region	hormone activity			endometrium(1)|large_intestine(1)	2						CACCTGATGGCGCAAATTGGG	0.677													7	24					0	0	1	0	0	T	5416147	C	T	5416147	3	4	48	1	0	0	0	0	1	0	0	0	16988	768	27	1	466	1	UCN3	10	5416147	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	410111	5416147	130118600	2324	6718										
TUBAL3	79861	broad.mit.edu	37	chr10	5435795	5435795	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaacagagtgcctcgacttCgtggctgcgattgctgcatt	12	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:5435795C>T	ENST00000380419.3	-	4	1063	c.1026G>A	c.(1024-1026)acG>acA	p.T342T	TUBAL3_ENST00000479328.1_Silent_p.T302T	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	342					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						GCCTCGACTTCGTGGCTGCGA	0.562													24	45					0	0	1	0	0	T	5435795	C	T	5435795	2	4	48	1	0	0	0	0	0	0	0	1	16812	871	31	1		1	TUBAL3	10	5435795	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19648	5435795	130098952	2325	6719										
FBXO18	84893	broad.mit.edu	37	chr10	5944989	5944989	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtatgaaacagtgagacGgtttaagcggaagcatctta	12	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:5944989G>A	ENST00000379999.5	+	3	265	c.161G>A	c.(160-162)cGg>cAg	p.R54Q	FBXO18_ENST00000362091.4_Missense_Mutation_p.R3Q|FBXO18_ENST00000470089.1_Intron|FBXO18_ENST00000397269.3_5'UTR	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	3					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						ACAGTGAGACGGTTTAAGCGG	0.458													16	47					0	0	1	0	0	A	5944989	G	A	5944989	3	1	48	1	0	0	0	0	1	0	0	0	5763	1116	39	1	176	1	FBXO18	10	5944989	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	509194	5944989	129589758	2326	6720										
IL2RA	3559	broad.mit.edu	37	chr10	6063552	6063552	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcaggacctctgtgtagagCcctgtatccctggacgcact	11	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:6063552C>T	ENST00000379959.3	-	4	645	c.472G>A	c.(472-474)Gct>Act	p.A158T	IL2RA_ENST00000256876.6_Missense_Mutation_p.A158T|IL2RA_ENST00000379954.1_Intron	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	158	Sushi 2.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	CTGTGTAGAGCCCTGTATCCC	0.527													56	88					0	0	1	0	0	T	6063552	C	T	6063552	3	4	48	1	0	0	0	0	1	0	0	0	7729	739	26	3	366	3	IL2RA	10	6063552	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	118563	6063552	129471195	2327	6721										
SFMBT2	57713	broad.mit.edu	37	chr10	7242375	7242375	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccctaaatgggactgattaCctgtggtgtccaggtgaggg	14	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:7242375C>T	ENST00000361972.4	-	14	1649		c.e14+1		SFMBT2_ENST00000397167.1_Splice_Site	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2						regulation of transcription, DNA-dependent	nucleus		p.?(1)		NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						GGACTGATTACCTGTGGTGTC	0.468													24	47					0	0	1	0	0	T	7242375	C	T	7242375	5	4	48	1	0	0	0	0	0	0	1	0	14211	521	18	3	1157	3	SFMBT2	10	7242375	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1178823	7242375	128292372	2328	6722										
SFMBT2	57713	broad.mit.edu	37	chr10	7285548	7285548	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagtgaggctgactccattTttaaggcaccactgtactgg	12	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:7285548T>G	ENST00000361972.4	-	9	1182	c.1092A>C	c.(1090-1092)aaA>aaC	p.K364N	SFMBT2_ENST00000397167.1_Missense_Mutation_p.K364N	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	364					regulation of transcription, DNA-dependent	nucleus		p.K364N(1)		NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						TGACTCCATTTTTAAGGCACC	0.448													24	51					0	0	1	0	0	G	7285548	T	G	7285548	3	3	48	1	0	0	0	0	1	0	0	0	14211	1838	64	4	1644	4	SFMBT2	10	7285548	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	43173	7285548	128249199	2329	6723										
ITIH5	80760	broad.mit.edu	37	chr10	7614359	7614359	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttcccttctgaagccacGaactgaaaaaaatgaaaaca	5	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:7614359G>A	ENST00000397145.2	-	12	2140	c.2035C>T	c.(2035-2037)Cgt>Tgt	p.R679C	ITIH5_ENST00000446830.2_Intron|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000298441.6_Intron|ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000256861.6_Intron	NM_001001851.2	NP_001001851.1	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	679					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CTGAAGCCACGAACTGAAAAA	0.363													6	16					0	0	1	0	0	A	7614359	G	A	7614359	3	1	48	1	0	0	0	0	1	0	0	0	7950	1058	37	1	928	1	ITIH5	10	7614359	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	328811	7614359	127920388	2330	6724										
ITIH2	3698	broad.mit.edu	37	chr10	7768987	7768987	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgtgattgatttcaaccaGaacattcgaacttggagaaa	8	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:7768987G>T	ENST00000358415.4	+	10	1225	c.1059G>T	c.(1057-1059)caG>caT	p.Q353H	ITIH2_ENST00000379587.4_Missense_Mutation_p.Q342H	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	353	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						ATTTCAACCAGAACATTCGAA	0.398													20	37					1.00905e-13	1.29777e-13	1	1	0	T	7768987	G	T	7768987	3	4	48	1	0	0	0	0	1	0	0	0	7947	933	33	2	1097	2	ITIH2	10	7768987	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	154628	7768987	127765760	2331	6725										
TAF3	83860	broad.mit.edu	37	chr10	8007253	8007253	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctacaagtttaaaatcaaaGaatttgaagatgttgatccc	6	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:8007253G>T	ENST00000344293.5	+	3	1986	c.1780G>T	c.(1780-1782)Gaa>Taa	p.E594*		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	594	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						TAAAATCAAAGAATTTGAAGA	0.373													31	41					6.00712e-18	8.10414e-18	1	1	0	T	8007253	G	T	8007253	4	4	48	1	0	0	0	0	0	1	0	0	15581	943	33	2	1790	2	TAF3	10	8007253	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	238266	8007253	127527494	2332	6726										
TAF3	83860	broad.mit.edu	37	chr10	8007600	8007600	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggacaaaaaggagaagaaGaaaaagaaggaaaaagagaa	12	1	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:8007600G>A	ENST00000344293.5	+	3	2333	c.2127G>A	c.(2125-2127)aaG>aaA	p.K709K		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	709	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						aggagaagaagaaaaagaagg	0.413													10	18					0	0	1	0	0	A	8007600	G	A	8007600	2	1	48	1	0	0	0	0	0	0	0	1	15581	933	33	3		3	TAF3	10	8007600	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	347	8007600	127527147	2333	6727										
UPF2	26019	broad.mit.edu	37	chr10	12071012	12071012	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgatcagcattaataatatTttttagctgttcatagatta	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:12071012T>G	ENST00000356352.2	-	2	1350	c.877A>C	c.(877-879)Aat>Cat	p.N293H	UPF2_ENST00000397053.2_Missense_Mutation_p.N293H|UPF2_ENST00000357604.5_Missense_Mutation_p.N293H			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	293	MIF4G 1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TTAATAATATTTTTTAGCTGT	0.378													22	26					0	0	1	0	0	G	12071012	T	G	12071012	3	3	48	1	0	0	0	0	1	0	0	0	17063	1841	64	4	3021	4	UPF2	10	12071012	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4063412	12071012	123463735	2334	6728										
DHTKD1	55526	broad.mit.edu	37	chr10	12136102	12136102	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggctgtgccatcatccatgTcaatggagacagcccagagg	13	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:12136102T>C	ENST00000263035.4	+	7	1252	c.1190T>C	c.(1189-1191)gTc>gCc	p.V397A	DHTKD1_ENST00000465617.1_3'UTR	NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	397					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			ATCATCCATGTCAATGGAGAC	0.517													21	91					0	0	1	0	0	C	12136102	T	C	12136102	3	2	48	1	0	0	0	0	1	0	0	0	4528	1667	58	4	1216	4	DHTKD1	10	12136102	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	65090	12136102	123398645	2335	6729										
SEPHS1	22929	broad.mit.edu	37	chr10	13375827	13375827	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaacttacatgataaattCattgggttggcagacagtgg	10	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:13375827C>A	ENST00000327347.5	-	5	925	c.550G>T	c.(550-552)Gaa>Taa	p.E184*	SEPHS1_ENST00000545675.1_Nonsense_Mutation_p.E184*|SEPHS1_ENST00000537130.1_Nonsense_Mutation_p.E117*|SEPHS1_ENST00000378614.4_Nonsense_Mutation_p.E184*	NM_001195602.1|NM_012247.4	NP_001182531.1|NP_036379.2	P49903	SPS1_HUMAN	selenophosphate synthetase 1	184					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						ATGATAAATTCATTGGGTTGG	0.438													18	19					1.33834e-09	1.61283e-09	1	1	0	A	13375827	C	A	13375827	4	1	48	1	0	0	0	0	0	1	0	0	14107	835	29	2	648	2	SEPHS1	10	13375827	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1239725	13375827	122158920	2336	6730										
FAM107B	83641	broad.mit.edu	37	chr10	14572353	14572353	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttgattcataagaagttCtctgtgaagatcttgatggt	9	4	3	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:14572353C>T	ENST00000181796.2	-	3	864	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K	FAM107B_ENST00000471815.1_5'UTR|FAM107B_ENST00000378470.1_Missense_Mutation_p.E36K|FAM107B_ENST00000378465.3_Missense_Mutation_p.E36K|FAM107B_ENST00000378467.4_Missense_Mutation_p.E36K|FAM107B_ENST00000478076.1_Missense_Mutation_p.E36K|FAM107B_ENST00000468747.1_Missense_Mutation_p.E36K|FAM107B_ENST00000378458.2_Missense_Mutation_p.E36K|FAM107B_ENST00000479731.1_Missense_Mutation_p.E36K|FAM107B_ENST00000378462.1_Missense_Mutation_p.E36K|FAM107B_ENST00000496330.1_Missense_Mutation_p.E36K	NM_031453.2	NP_113641.2	Q9H098	F107B_HUMAN	family with sequence similarity 107, member B	36										breast(7)|kidney(1)|large_intestine(4)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATAAGAAGTTCTCTGTGAAGA	0.333													22	56					0	0	1	0	0	T	14572353	C	T	14572353	3	4	48	1	0	0	0	0	1	0	0	0	5421	922	32	3	301	3	FAM107B	10	14572353	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1196526	14572353	120962394	2337	6731										
FAM107B	83641	broad.mit.edu	37	chr10	14709678	14709678	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggcatttaggttcttctcGaaattcttcttcctaagcgc	8	10	4	0	rs111681891		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:14709678G>A	ENST00000181796.2	-	2	657	c.424C>T	c.(424-426)Cga>Tga	p.R142*		NM_031453.2	NP_113641.2	Q9H098	F107B_HUMAN	family with sequence similarity 107, member B	74										breast(7)|kidney(1)|large_intestine(4)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GGTTCTTCTCGAAATTCTTCT	0.423													16	21					0	0	1	0	0	A	14709678	G	A	14709678	4	1	48	1	0	0	0	0	0	1	0	0	5421	1066	37	1	512	1	FAM107B	10	14709678	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	137325	14709678	120825069	2338	6732										
FAM107B	83641	broad.mit.edu	37	chr10	14816376	14816376	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgcgggctgggccgcagtgCggtgacttgaattccgattc	15	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:14816376C>T	ENST00000181796.2	-	1	520	c.287G>A	c.(286-288)cGc>cAc	p.R96H		NM_031453.2	NP_113641.2	Q9H098	F107B_HUMAN	family with sequence similarity 107, member B	0										breast(7)|kidney(1)|large_intestine(4)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GGCCGCAGTGCGGTGACTTGA	0.592													68	144					0	0	1	0	0	T	14816376	C	T	14816376	3	4	48	1	0	0	0	0	1	0	0	0	5421	768	27	1	653	1	FAM107B	10	14816376	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	106698	14816376	120718371	2339	6733										
ITGA8	8516	broad.mit.edu	37	chr10	15720728	15720728	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaataattcaccttataaAaatccagactaaatcctgct	2	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:15720728A>C	ENST00000378076.3	-	5	976	c.623T>G	c.(622-624)tTt>tGt	p.F208C		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	208					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CACCTTATAAAAATCCAGACT	0.403													27	36					0	0	1	0	0	C	15720728	A	C	15720728	3	2	48	1	0	0	0	0	1	0	0	0	7925	14	1	4	2672	4	ITGA8	10	15720728	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	904352	15720728	119814019	2340	6734										
CUBN	8029	broad.mit.edu	37	chr10	16878296	16878296	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caactccagatttgaaaatgAccattgcagtactcatagaa	6	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:16878296A>G	ENST00000377833.4	-	63	10183	c.10118T>C	c.(10117-10119)gTc>gCc	p.V3373A		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3373	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTTGAAAATGACCATTGCAGT	0.398													15	33					0	0	1	0	0	G	16878296	A	G	16878296	3	3	48	1	0	0	0	0	1	0	0	0	4074	275	10	4	773	4	CUBN	10	16878296	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1157568	16878296	118656451	2341	6735										
CUBN	8029	broad.mit.edu	37	chr10	16948356	16948356	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taattcctgactccgtcataGccaggagaagtaaagtttcc	8	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:16948356G>A	ENST00000377833.4	-	50	7823	c.7758C>T	c.(7756-7758)ggC>ggT	p.G2586G		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2586	CUB 19.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTCCGTCATAGCCAGGAGAAG	0.418													22	45					0	0	1	0	0	A	16948356	G	A	16948356	2	1	48	1	0	0	0	0	0	0	0	1	4074	958	34	3		3	CUBN	10	16948356	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	70060	16948356	118586391	2342	6736										
TRDMT1	1787	broad.mit.edu	37	chr10	17195593	17195593	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taacagctttgttatctgttCttcttgtgacaaattggtaa	7	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:17195593C>A	ENST00000377799.3	-	10	1035	c.988G>T	c.(988-990)Gaa>Taa	p.E330*	TRDMT1_ENST00000488990.1_Nonsense_Mutation_p.E207*|TRDMT1_ENST00000358282.7_3'UTR|TRDMT1_ENST00000457442.2_Nonsense_Mutation_p.E249*|TRDMT1_ENST00000351358.4_Nonsense_Mutation_p.E284*|TRDMT1_ENST00000377766.5_3'UTR|TRDMT1_ENST00000412821.3_Nonsense_Mutation_p.E306*|TRDMT1_ENST00000452380.2_5'UTR	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	330					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						GTTATCTGTTCTTCTTGTGAC	0.343													10	20					0.000442599	0.00046913	1	1	0	A	17195593	C	A	17195593	4	1	48	1	0	0	0	0	0	1	0	0	16527	922	32	2	195	2	TRDMT1	10	17195593	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	247237	17195593	118339154	2343	6737										
ST8SIA6	338596	broad.mit.edu	37	chr10	17365098	17365098	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttggatttatagtcacaaGatttgttttactgccaacat	7	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:17365098G>A	ENST00000377602.4	-	7	768	c.694C>T	c.(694-696)Ctt>Ttt	p.L232F		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	232					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						ATAGTCACAAGATTTGTTTTA	0.343													21	46					0	0	1	0	0	A	17365098	G	A	17365098	3	1	48	1	0	0	0	0	1	0	0	0	15291	942	33	3	510	3	ST8SIA6	10	17365098	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	169505	17365098	118169649	2344	6738										
NEBL	10529	broad.mit.edu	37	chr10	21074700	21074700	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaacaaactcaatgtaattCgctgggagcattcctgttct	7	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:21074700C>T	ENST00000377122.4	-	28	3417	c.3021G>A	c.(3019-3021)gcG>gcA	p.A1007A	NEBL_ENST00000417816.2_Silent_p.A263A|NEBL_ENST00000377159.4_Silent_p.A229A	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	1007	SH3.				regulation of actin filament length		actin binding|structural constituent of muscle	p.A263A(1)|p.A1007A(1)		NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CAATGTAATTCGCTGGGAGCA	0.413													13	23					0	0	1	0	0	T	21074700	C	T	21074700	2	4	48	1	0	0	0	0	0	0	0	1	10349	871	31	1		1	NEBL	10	21074700	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3709602	21074700	114460047	2345	6739										
KIAA1217	56243	broad.mit.edu	37	chr10	24820774	24820774	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagaagattctccaaattCggaacaggacttggaaaagc	9	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:24820774C>T	ENST00000376451.2	+	10	2407	c.2147C>T	c.(2146-2148)tCg>tTg	p.S716L	KIAA1217_ENST00000307544.6_Missense_Mutation_p.S716L|KIAA1217_ENST00000376454.3_Missense_Mutation_p.S1033L|KIAA1217_ENST00000376462.1_Missense_Mutation_p.S953L|KIAA1217_ENST00000396445.1_Missense_Mutation_p.S716L|KIAA1217_ENST00000396446.1_Missense_Mutation_p.S716L|KIAA1217_ENST00000430453.2_3'UTR|KIAA1217_ENST00000376452.3_Missense_Mutation_p.S997L|KIAA1217_ENST00000458595.1_Missense_Mutation_p.S998L			Q5T5P2	SKT_HUMAN	KIAA1217	1033					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TCTCCAAATTCGGAACAGGAC	0.493													14	19					0	0	1	0	0	T	24820774	C	T	24820774	3	4	48	1	0	0	0	0	1	0	0	0	8257	893	31	1	3156	1	KIAA1217	10	24820774	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3746074	24820774	110713973	2346	6740										
ARHGAP21	57584	broad.mit.edu	37	chr10	24910202	24910202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catggctgatggggcagatgGcagccagggatagcagattg	17	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:24910202G>A	ENST00000396432.2	-	9	1108	c.622C>T	c.(622-624)Cca>Tca	p.P208S	ARHGAP21_ENST00000320481.6_5'UTR	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	207					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GGGGCAGATGGCAGCCAGGGA	0.502													6	20					0	0	1	0	0	A	24910202	G	A	24910202	3	1	48	1	0	0	0	0	1	0	0	0	868	1203	42	3	5326	3	ARHGAP21	10	24910202	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	89428	24910202	110624545	2347	6741										
THNSL1	79896	broad.mit.edu	37	chr10	25314002	25314002	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagcaggattttgtagctgActggtgctctgagggagagt	15	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:25314002A>G	ENST00000524413.1	+	3	2197	c.1850A>G	c.(1849-1851)gAc>gGc	p.D617G	THNSL1_ENST00000376356.4_Missense_Mutation_p.D617G			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	617					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	TTTGTAGCTGACTGGTGCTCT	0.413													29	45					0	0	1	0	0	G	25314002	A	G	25314002	3	3	48	1	0	0	0	0	1	0	0	0	15921	275	10	4	1852	4	THNSL1	10	25314002	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	403800	25314002	110220745	2348	6742										
GPR158	57512	broad.mit.edu	37	chr10	25887640	25887640	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcaaaagttcaaaagcacGtatctattgtggcttctgaa	7	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:25887640G>A	ENST00000376351.3	+	11	3444	c.3085G>A	c.(3085-3087)Gta>Ata	p.V1029I	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1029						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TCAAAAGCACGTATCTATTGT	0.458													19	52					0	0	1	0	0	A	25887640	G	A	25887640	3	1	48	1	0	0	0	0	1	0	0	0	6702	1145	40	1	3127	1	GPR158	10	25887640	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	573638	25887640	109647107	2349	6743										
GPR158	57512	broad.mit.edu	37	chr10	25887693	25887693	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccactttttccttaaaggaGaaatctcaccacaagcctaa	4	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:25887693G>T	ENST00000376351.3	+	11	3497	c.3138G>T	c.(3136-3138)gaG>gaT	p.E1046D	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1046						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCTTAAAGGAGAAATCTCACC	0.463													23	59					1.85244e-09	2.22951e-09	1	1	0	T	25887693	G	T	25887693	3	4	48	1	0	0	0	0	1	0	0	0	6702	933	33	2	3180	2	GPR158	10	25887693	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53	25887693	109647054	2350	6744										
MYO3A	53904	broad.mit.edu	37	chr10	26465660	26465660	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatctgaagaatatttcattCtgcagaaaaaattgaatgaa	6	4	3	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:26465660C>A	ENST00000265944.5	+	31	4490	c.4324C>A	c.(4324-4326)Ctg>Atg	p.L1442M	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1442					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						ATATTTCATTCTGCAGAAAAA	0.378													8	31					0.0381472	0.0387537	1	1	0	A	26465660	C	A	26465660	3	1	48	1	0	0	0	0	1	0	0	0	10123	912	32	2	4438	2	MYO3A	10	26465660	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	577967	26465660	109069087	2351	6745										
PDSS1	23590	broad.mit.edu	37	chr10	27012969	27012969	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttcagctcgggtcaaaaGaaaatgagaatgaaagattt	9	5	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:27012969G>T	ENST00000376215.5	+	8	801	c.748G>T	c.(748-750)Gaa>Taa	p.E250*	PDSS1_ENST00000376203.5_Nonsense_Mutation_p.E250*	NM_014317.3	NP_055132.2	Q5T2R2	DPS1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 1	250					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity			autonomic_ganglia(1)|endometrium(1)|kidney(7)|large_intestine(6)|lung(5)|prostate(1)	21						CGGGTCAAAAGAAAATGAGAA	0.413													19	47					2.37509e-13	3.04217e-13	1	1	0	T	27012969	G	T	27012969	4	4	48	1	0	0	0	0	0	1	0	0	11739	943	33	2	778	2	PDSS1	10	27012969	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	547309	27012969	108521778	2352	6746										
ABI1	10006	broad.mit.edu	37	chr10	27052890	27052890	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggagggacagaaatgttttCtaataaaatagtttataatt	8	2	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:27052890C>A	ENST00000355394.4	-	8	1047		c.e8-1		ABI1_ENST00000346832.5_Splice_Site|ABI1_ENST00000490841.2_Intron|ABI1_ENST00000376134.3_Intron|ABI1_ENST00000376138.3_Intron|ABI1_ENST00000376139.2_Intron|ABI1_ENST00000376137.4_Intron|ABI1_ENST00000376140.3_Intron|ABI1_ENST00000376142.2_Splice_Site|ABI1_ENST00000536334.1_Intron|ABI1_ENST00000376160.1_Intron|ABI1_ENST00000376166.1_Intron|ABI1_ENST00000359188.4_Intron|ABI1_ENST00000376170.4_Intron			Q8IZP0	ABI1_HUMAN	abl-interactor 1						actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAAATGTTTTCTAATAAAATA	0.398													12	28					0.00010058	0.000108553	1	1	0	A	27052890	C	A	27052890	5	1	48	1	0	0	0	0	0	0	1	0	88	927	32	2	726	2	ABI1	10	27052890	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	39921	27052890	108481857	2353	6747										
YME1L1	10730	broad.mit.edu	37	chr10	27411889	27411889	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatataacacaaggagcattCgcctttgcttcccctaagaa	6	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:27411889C>T	ENST00000326799.3	-	12	1435	c.1287G>A	c.(1285-1287)gcG>gcA	p.A429A	YME1L1_ENST00000376016.3_Silent_p.A372A|YME1L1_ENST00000375972.3_Silent_p.A339A	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	429					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						AAGGAGCATTCGCCTTTGCTT	0.328													16	32					0	0	1	0	0	T	27411889	C	T	27411889	2	4	48	1	0	0	0	0	0	0	0	1	17546	871	31	1		1	YME1L1	10	27411889	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	358999	27411889	108122858	2354	6748										
RAB18	22931	broad.mit.edu	37	chr10	27826849	27826849	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtacaatgtgcctttgaaGaacttgttgaaaagatcatt	9	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:27826849G>T	ENST00000356940.6	+	7	592	c.490G>T	c.(490-492)Gaa>Taa	p.E164*	RAB18_ENST00000535776.1_Nonsense_Mutation_p.E100*|RAB18_ENST00000465772.1_3'UTR|RAB18_ENST00000375802.3_Nonsense_Mutation_p.E119*	NM_001256410.1|NM_001256415.1|NM_021252.4	NP_001243339.1|NP_001243344.1|NP_067075.1	Q9NP72	RAB18_HUMAN	RAB18, member RAS oncogene family	164					endocytosis|protein transport|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|GTPase activity|transcription factor binding			kidney(1)|large_intestine(1)|lung(1)	3						TGCCTTTGAAGAACTTGTTGA	0.428													25	50					1.10923e-09	1.34134e-09	1	1	0	T	27826849	G	T	27826849	4	4	48	1	0	0	0	0	0	1	0	0	12954	943	33	2	516	2	RAB18	10	27826849	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	414960	27826849	107707898	2355	6749										
MKX	283078	broad.mit.edu	37	chr10	28023451	28023451	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactaattcttcctcaaattCattggagctaaaagatcccg	5	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:28023451C>A	ENST00000375790.5	-	5	1204	c.772G>T	c.(772-774)Gaa>Taa	p.E258*	MKX_ENST00000419761.1_Nonsense_Mutation_p.E258*			Q8IYA7	MKX_HUMAN	mohawk homeobox	258					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						TCCTCAAATTCATTGGAGCTA	0.433													37	71					5.43694e-19	7.38452e-19	1	1	0	A	28023451	C	A	28023451	4	1	48	1	0	0	0	0	0	1	0	0	9657	835	29	2	298	2	MKX	10	28023451	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	196602	28023451	107511296	2356	6750										
ARMC4	55130	broad.mit.edu	37	chr10	28270421	28270421	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacatattttctgaaaattTtggtgatttttctcttaaaa	5	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:28270421T>C	ENST00000305242.5	-	7	1002	c.910A>G	c.(910-912)Aaa>Gaa	p.K304E	ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000545014.1_5'UTR|ARMC4_ENST00000537576.1_5'UTR|ARMC4_ENST00000239715.3_Missense_Mutation_p.K161E	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	304							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TCTGAAAATTTTGGTGATTTT	0.294													14	32					0	0	1	0	0	C	28270421	T	C	28270421	3	2	48	1	0	0	0	0	1	0	0	0	952	1850	64	4	2280	4	ARMC4	10	28270421	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	246970	28270421	107264326	2357	6751										
SVIL	6840	broad.mit.edu	37	chr10	29769557	29769557	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggggagcctgctatagtcGaattccaggatgtgccagac	13	9	0	1	rs150357239	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:29769557G>A	ENST00000375398.2	-	31	5735	c.5286C>T	c.(5284-5286)ttC>ttT	p.F1762F	PTCHD3P1_ENST00000413405.1_RNA|SVIL_ENST00000535393.1_Silent_p.F676F|SVIL_ENST00000375400.3_Silent_p.F1336F|SVIL_ENST00000355867.4_Silent_p.F1762F|PTCHD3P1_ENST00000414457.1_RNA|SVIL_ENST00000538146.1_Silent_p.F554F|PTCHD3P1_ENST00000446807.1_RNA|SVIL_ENST00000460007.1_5'UTR|PTCHD3P1_ENST00000423223.1_RNA			O95425	SVIL_HUMAN	supervillin	1762					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TGCTATAGTCGAATTCCAGGA	0.557													38	65					0	0	1	0	0	A	29769557	G	A	29769557	2	1	48	1	0	0	0	0	0	0	0	1	15476	1049	37	1		1	SVIL	10	29769557	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1499136	29769557	105765190	2358	6752										
MAP3K8	1326	broad.mit.edu	37	chr10	30728192	30728192	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccacaggaatctggaattTtattaaacatggtacgtttc	8	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:30728192T>G	ENST00000263056.1	+	3	1021	c.325T>G	c.(325-327)Tta>Gta	p.L109V	MAP3K8_ENST00000375321.1_Missense_Mutation_p.L109V|MAP3K8_ENST00000375322.2_Missense_Mutation_p.L109V|MAP3K8_ENST00000542547.1_Missense_Mutation_p.L109V	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	109					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				ATCTGGAATTTTATTAAACAT	0.403													25	32					0	0	1	0	0	G	30728192	T	G	30728192	3	3	48	1	0	0	0	0	1	0	0	0	9305	1838	64	4	327	4	MAP3K8	10	30728192	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	958635	30728192	104806555	2359	6753										
MAP3K8	1326	broad.mit.edu	37	chr10	30740639	30740639	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtgttcaaatgaccgaagAtgtctattttcctaaggacc	8	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:30740639A>G	ENST00000263056.1	+	6	1535	c.839A>G	c.(838-840)gAt>gGt	p.D280G	MAP3K8_ENST00000375321.1_Missense_Mutation_p.D280G|MAP3K8_ENST00000542547.1_Missense_Mutation_p.D280G	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	280	Protein kinase.				cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				ATGACCGAAGATGTCTATTTT	0.328													20	35					0	0	1	0	0	G	30740639	A	G	30740639	3	3	48	1	0	0	0	0	1	0	0	0	9305	333	12	4	853	4	MAP3K8	10	30740639	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	12447	30740639	104794108	2360	6754										
KIF5B	3799	broad.mit.edu	37	chr10	32306131	32306131	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgactgcttcctttatgcGatctacttcttgctgatagc	7	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:32306131G>A	ENST00000302418.4	-	24	3158	c.2701C>T	c.(2701-2703)Cgc>Tgc	p.R901C		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	901					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				TCCTTTATGCGATCTACTTCT	0.418			T	"RET, ALK"	NSCLC								68	143					0	0	1	0	0	A	32306131	G	A	32306131	3	1	48	1	0	0	0	0	1	0	0	0	8347	1058	37	1	198	1	KIF5B	10	32306131	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1565492	32306131	103228616	2361	6755										
EPC1	80314	broad.mit.edu	37	chr10	32561054	32561054	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaccaaagcagaagcagcAaactgtgcactagcagaatc	9	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:32561054A>G	ENST00000319778.6	-	12	2207	c.1905T>C	c.(1903-1905)ttT>ttC	p.F635F	EPC1_ENST00000263062.8_Silent_p.F658F|EPC1_ENST00000375110.2_Silent_p.F585F	NM_001272004.1|NM_001272019.1	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	658					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				CAGAAGCAGCAAACTGTGCAC	0.398													15	29					0	0	1	0	0	G	32561054	A	G	32561054	2	3	48	1	0	0	0	0	0	0	0	1	5188	127	5	4		4	EPC1	10	32561054	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	254923	32561054	102973693	2362	6756										
CCDC7	221016	broad.mit.edu	37	chr10	32745259	32745259	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagcacttaaagaagaacaAaatgtatgtattctgtatat	7	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:32745259A>C	ENST00000545067.1	+	4	749	c.453A>C	c.(451-453)caA>caC	p.Q151H	CCDC7_ENST00000535327.1_Missense_Mutation_p.Q151H|CCDC7_ENST00000537047.1_Missense_Mutation_p.Q151H|CCDC7_ENST00000539197.1_Missense_Mutation_p.Q151H|CCDC7_ENST00000362006.5_Missense_Mutation_p.Q151H|CCDC7_ENST00000277657.6_Missense_Mutation_p.Q151H			Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7	151										NS(1)|breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)	14		Breast(68;0.000207)|Prostate(175;0.0107)				AAGAAGAACAAAATGTATGTA	0.313													12	18					0	0	1	0	0	C	32745259	A	C	32745259	3	2	48	1	0	0	0	0	1	0	0	0	2862	11	1	4	463	4	CCDC7	10	32745259	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	184205	32745259	102789488	2363	6757										
ZNF25	219749	broad.mit.edu	37	chr10	38242653	38242653	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcttggctttcctggtatCttgcttctagatcatgaatg	9	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:38242653C>A	ENST00000302609.7	-	5	484	c.272G>T	c.(271-273)aGa>aTa	p.R91I	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				TTCCTGGTATCTTGCTTCTAG	0.328													4	31					0.150653	0.151842	1	1	0	A	38242653	C	A	38242653	3	1	48	1	0	0	0	0	1	0	0	0	17851	913	32	2	1106	2	ZNF25	10	38242653	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5497394	38242653	97292094	2364	6758										
ZNF33A	7581	broad.mit.edu	37	chr10	38344819	38344819	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcatgaatgtggaaaaatCttttacaataaatcatacct	5	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:38344819C>A	ENST00000374618.3	+	5	1945	c.1767C>A	c.(1765-1767)atC>atA	p.I589I	ZNF33A_ENST00000432900.2_Silent_p.I595I|ZNF33A_ENST00000307441.9_Silent_p.I588I|ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000458705.2_Silent_p.I588I	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	588						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						GTGGAAAAATCTTTTACAATA	0.378													26	60					1.42536e-11	1.77514e-11	1	1	0	A	38344819	C	A	38344819	2	1	48	1	0	0	0	0	0	0	0	1	17910	903	32	2		2	ZNF33A	10	38344819	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	102166	38344819	97189928	2365	6759										
ZNF37A	7587	broad.mit.edu	37	chr10	38406445	38406445	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaccttctgaatataataaAaatgggaacagcttctggct	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:38406445A>C	ENST00000351773.3	+	8	1196	c.366A>C	c.(364-366)aaA>aaC	p.K122N	ZNF37A_ENST00000361085.4_Missense_Mutation_p.K122N	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	122						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						AATATAATAAAAATGGGAACA	0.328													35	82					0	0	1	0	0	C	38406445	A	C	38406445	3	2	48	1	0	0	0	0	1	0	0	0	17928	11	1	4	380	4	ZNF37A	10	38406445	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	61626	38406445	97128302	2366	6760										
ZNF485	220992	broad.mit.edu	37	chr10	44112192	44112192	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatccttttaagtcatcagaGaattcatactggccagaaac	6	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:44112192G>T	ENST00000361807.3	+	5	895	c.701G>T	c.(700-702)aGa>aTa	p.R234I	ZNF485_ENST00000374435.3_Missense_Mutation_p.R234I|ZNF485_ENST00000374437.2_Missense_Mutation_p.R143I	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						AGTCATCAGAGAATTCATACT	0.393													23	37					3.28513e-13	4.19729e-13	1	1	0	T	44112192	G	T	44112192	3	4	48	1	0	0	0	0	1	0	0	0	17994	942	33	2	715	2	ZNF485	10	44112192	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5705747	44112192	91422555	2367	6761										
ZNF485	220992	broad.mit.edu	37	chr10	44112550	44112550	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcacagtggaaataaaccGtatcagtgtcgtgactgtgg	11	8	2	1	rs141606024	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:44112550G>A	ENST00000361807.3	+	5	1253	c.1059G>A	c.(1057-1059)ccG>ccA	p.P353P	ZNF485_ENST00000374435.3_Silent_p.P353P|ZNF485_ENST00000374437.2_Silent_p.P262P	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						GAAATAAACCGTATCAGTGTC	0.418													22	50					0	0	1	0	0	A	44112550	G	A	44112550	2	1	48	1	0	0	0	0	0	0	0	1	17994	1132	40	1		1	ZNF485	10	44112550	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	358	44112550	91422197	2368	6762										
ALOX5	240	broad.mit.edu	37	chr10	45936008	45936008	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccatcacccaccttctgcGaacacatctggtgtctgagg	9	14	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:45936008G>A	ENST00000374391.2	+	8	1165	c.1112G>A	c.(1111-1113)cGa>cAa	p.R371Q	ALOX5_ENST00000542434.1_Missense_Mutation_p.R371Q	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	371	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding	p.R371Q(1)		breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CACCTTCTGCGAACACATCTG	0.537													17	24					0	0	1	0	0	A	45936008	G	A	45936008	3	1	48	1	0	0	0	0	1	0	0	0	536	1058	37	1	1142	1	ALOX5	10	45936008	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1823458	45936008	89598739	2369	6763										
RBP3	5949	broad.mit.edu	37	chr10	48388279	48388279	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccgtgggctccccaatgaCcgtggcccgctgcaggtcct	14	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:48388279C>T	ENST00000224600.4	-	1	2712	c.2599G>A	c.(2599-2601)Gtc>Atc	p.V867I		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	867	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	TCCCCAATGACCGTGGCCCGC	0.632													10	28					0	0	1	0	0	T	48388279	C	T	48388279	3	4	48	1	0	0	0	0	1	0	0	0	13208	507	18	3	1160	3	RBP3	10	48388279	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2452271	48388279	87146468	2370	6764										
RBP3	5949	broad.mit.edu	37	chr10	48389205	48389205	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagtgtggcccagcccagcGactgcataaggaaggcgaac	13	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:48389205G>A	ENST00000224600.4	-	1	1786	c.1673C>T	c.(1672-1674)tCg>tTg	p.S558L		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	558	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCAGCCCAGCGACTGCATAAG	0.687													26	51					0	0	1	0	0	A	48389205	G	A	48389205	3	1	48	1	0	0	0	0	1	0	0	0	13208	1059	37	1	2086	1	RBP3	10	48389205	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	926	48389205	87145542	2371	6765										
GDF2	2658	broad.mit.edu	37	chr10	48413860	48413860	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtcccagccgatgtcctcGaagtttacccgcagggaggt	12	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:48413860G>A	ENST00000249598.1	-	2	1167	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	336					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity	p.F336F(1)		breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CGATGTCCTCGAAGTTTACCC	0.607													28	62					0	0	1	0	0	A	48413860	G	A	48413860	2	1	48	1	0	0	0	0	0	0	0	1	6355	1049	37	1		1	GDF2	10	48413860	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24655	48413860	87120887	2372	6766										
ERCC6	2074	broad.mit.edu	37	chr10	50732662	50732662	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgatctgccaaatacttttCgaagcctgatgcttcattaa	6	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:50732662C>T	ENST00000355832.5	-	5	892	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.E272K|PGBD3_ENST00000603152.1_Missense_Mutation_p.E272K|ERCC6-PGBD3_ENST00000515869.1_Missense_Mutation_p.E272K	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	272					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AAATACTTTTCGAAGCCTGAT	0.458								Direct reversal of damage;Nucleotide excision repair (NER)					47	85					0	0	1	0	0	T	50732662	C	T	50732662	3	4	48	1	0	0	0	0	1	0	0	0	5245	893	31	1	3735	1	ERCC6	10	50732662	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2318802	50732662	84802085	2373	6767										
SLC18A3	6572	broad.mit.edu	37	chr10	50819033	50819033	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtgtgggagcccaccctgCcgctgcccactccggccaat	12	17	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:50819033C>T	ENST00000374115.3	+	1	687	c.247C>T	c.(247-249)Ccg>Tcg	p.P83S	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	83					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						GCCCACCCTGCCGCTGCCCAC	0.721													11	26					0	0	1	0	0	T	50819033	C	T	50819033	3	4	48	1	0	0	0	0	1	0	0	0	14481	739	26	3	249	3	SLC18A3	10	50819033	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	86371	50819033	84715714	2374	6768										
SLC18A3	6572	broad.mit.edu	37	chr10	50820378	50820378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctacaactactactacacccGcagctagcatccccactcct	3	19	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:50820378G>A	ENST00000374115.3	+	1	2032	c.1592G>A	c.(1591-1593)cGc>cAc	p.R531H	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	531					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						TACTACACCCGCAGCTAGCAT	0.667													15	133					0	0	1	0	0	A	50820378	G	A	50820378	3	1	48	1	0	0	0	0	1	0	0	0	14481	1087	38	1	1594	1	SLC18A3	10	50820378	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1345	50820378	84714369	2375	6769										
C10orf53	282966	broad.mit.edu	37	chr10	50902001	50902001	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgaggagtccctcaatttCtagttgaaatgatcagtgta	9	7	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:50902001C>A	ENST00000374113.3	+	2	326	c.279C>A	c.(277-279)ttC>ttA	p.F93L	C10orf53_ENST00000535836.1_Intron|C10orf53_ENST00000374112.3_Intron|C10orf53_ENST00000374111.3_Intron			Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53	0										endometrium(1)|lung(6)	7		all_neural(218;0.107)				CCCTCAATTTCTAGTTGAAAT	0.453													10	35					0.000442599	0.00046913	1	1	0	A	50902001	C	A	50902001	3	1	48	1	0	0	0	0	1	0	0	0	1610	928	32	2		2	C10orf53	10	50902001	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	81623	50902001	84632746	2376	6770										
OGDHL	55753	broad.mit.edu	37	chr10	50943287	50943287	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagctctaaaatgtcttgCcctcaaaggcctggagattg	9	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:50943287C>T	ENST00000374103.4	-	23	3105	c.3020G>A	c.(3019-3021)gGc>gAc	p.G1007D	OGDHL_ENST00000419399.1_Missense_Mutation_p.G950D|OGDHL_ENST00000432695.1_Missense_Mutation_p.G798D|OGDHL_ENST00000490844.1_5'UTR	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	1007					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						AAATGTCTTGCCCTCAAAGGC	0.572													49	70					0	0	1	0	0	T	50943287	C	T	50943287	3	4	48	1	0	0	0	0	1	0	0	0	10887	739	26	3	16	3	OGDHL	10	50943287	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	41286	50943287	84591460	2377	6771										
OGDHL	55753	broad.mit.edu	37	chr10	50952051	50952051	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacctcaccagtgtggatcTtaaagtcctccaggggcaca	9	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:50952051T>C	ENST00000374103.4	-	14	1935	c.1850A>G	c.(1849-1851)aAg>aGg	p.K617R	OGDHL_ENST00000419399.1_Missense_Mutation_p.K560R|OGDHL_ENST00000432695.1_Missense_Mutation_p.K408R	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	617					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						AGTGTGGATCTTAAAGTCCTC	0.617													16	29					0	0	1	0	0	C	50952051	T	C	50952051	3	2	48	1	0	0	0	0	1	0	0	0	10887	1609	56	4	1222	4	OGDHL	10	50952051	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8764	50952051	84582696	2378	6772										
SGMS1	259230	broad.mit.edu	37	chr10	52066985	52066985	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaaggccaatggtaagatcGaggtacaattccttggacat	11	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:52066985G>A	ENST00000361781.2	-	11	2118	c.1159C>T	c.(1159-1161)Cga>Tga	p.R387*	SGMS1_ENST00000429490.1_Nonsense_Mutation_p.R218*	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	393					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity	p.R387*(1)		endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TGGTAAGATCGAGGTACAATT	0.493													21	29					0	0	1	0	0	A	52066985	G	A	52066985	4	1	48	1	0	0	0	0	0	1	0	0	14267	1066	37	1	86	1	SGMS1	10	52066985	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1114934	52066985	83467762	2379	6773										
A1CF	29974	broad.mit.edu	37	chr10	52601750	52601750	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatttcataaattttaccGatctgcaagtaatagaaata	4	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:52601750G>A	ENST00000395489.2	-	7	612	c.216C>T	c.(214-216)atC>atT	p.I72I	A1CF_ENST00000373997.3_Silent_p.I79I|A1CF_ENST00000373993.1_Silent_p.I79I|A1CF_ENST00000373995.3_Silent_p.I87I|A1CF_ENST00000395495.1_Silent_p.I79I|A1CF_ENST00000282641.2_Silent_p.I79I|A1CF_ENST00000374001.1_Silent_p.I79I	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	79	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						AAATTTTACCGATCTGCAAGT	0.318													8	18					0	0	1	0	0	A	52601750	G	A	52601750	2	1	48	1	0	0	0	0	0	0	0	1	2	1048	37	1		1	A1CF	10	52601750	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	534765	52601750	82932997	2380	6774										
DKK1	22943	broad.mit.edu	37	chr10	54076093	54076093	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaaaatcatttccgaggaGaaattgaggaaaccatcact	7	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:54076093G>T	ENST00000373970.3	+	3	584	c.445G>T	c.(445-447)Gaa>Taa	p.E149*	DKK1_ENST00000467359.1_3'UTR	NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	149					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						TTTCCGAGGAGAAATTGAGGA	0.393													15	21					1.15088e-07	1.32965e-07	1	1	0	T	54076093	G	T	54076093	4	4	48	1	0	0	0	0	0	1	0	0	4572	943	33	2	455	2	DKK1	10	54076093	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1474343	54076093	81458654	2381	6775										
DKK1	22943	broad.mit.edu	37	chr10	54076160	54076160	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttggatgggtattccagaaGaaccaccttgtcttcaaaaa	8	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:54076160G>T	ENST00000373970.3	+	3	651	c.512G>T	c.(511-513)aGa>aTa	p.R171I	DKK1_ENST00000467359.1_3'UTR	NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	171					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						TATTCCAGAAGAACCACCTTG	0.373													4	47					1.23904e-05	1.36503e-05	1	1	0	T	54076160	G	T	54076160	3	4	48	1	0	0	0	0	1	0	0	0	4572	942	33	2	522	2	DKK1	10	54076160	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	67	54076160	81458587	2382	6776										
PCDH15	65217	broad.mit.edu	37	chr10	55569282	55569282	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctctaatttcaacctttgGttttttaattttctttggct	4	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:55569282G>T	ENST00000395438.1	-	36	4972	c.4578C>A	c.(4576-4578)aaC>aaA	p.N1526K	PCDH15_ENST00000395442.1_Missense_Mutation_p.P375T|PCDH15_ENST00000395440.1_Missense_Mutation_p.P444T|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.P1510T|PCDH15_ENST00000409834.1_Missense_Mutation_p.N1137K|PCDH15_ENST00000395446.1_Missense_Mutation_p.P706T|PCDH15_ENST00000373965.2_Intron	NM_001142770.1	NP_001136242.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCAACCTTTGGTTTTTTAATT	0.413										HNSCC(58;0.16)			14	150					6.72482e-11	8.31618e-11	1	1	0	T	55569282	G	T	55569282	3	4	48	1	0	0	0	0	1	0	0	0	11557	1261	44	5	1388	5	PCDH15	10	55569282	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1493122	55569282	79965465	2383	6777										
PCDH15	65217	broad.mit.edu	37	chr10	55626542	55626542	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttccactacaaatccttCttttccctctttaattggtg	4	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:55626542C>A	ENST00000373965.2	-	28	3992	c.3598G>T	c.(3598-3600)Gaa>Taa	p.E1200*	PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Nonsense_Mutation_p.E1198*|PCDH15_ENST00000361849.3_Nonsense_Mutation_p.E1193*|PCDH15_ENST00000395430.1_Nonsense_Mutation_p.E1193*|PCDH15_ENST00000395445.1_Nonsense_Mutation_p.E1200*|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000409834.1_Nonsense_Mutation_p.E804*|PCDH15_ENST00000437009.1_Nonsense_Mutation_p.E1122*|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395438.1_Nonsense_Mutation_p.E1193*|PCDH15_ENST00000395433.1_Nonsense_Mutation_p.E1171*|PCDH15_ENST00000320301.6_Nonsense_Mutation_p.E1193*|PCDH15_ENST00000395432.2_Nonsense_Mutation_p.E1156*	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1193	Cadherin 11.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACAAATCCTTCTTTTCCCTCT	0.378										HNSCC(58;0.16)			25	29					4.26978e-12	5.35675e-12	1	1	0	A	55626542	C	A	55626542	4	1	48	1	0	0	0	0	0	1	0	0	11557	922	32	2	3937	2	PCDH15	10	55626542	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	57260	55626542	79908205	2384	6778										
PCDH15	65217	broad.mit.edu	37	chr10	55944895	55944895	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacacaaaagctctttaccGaaaaggtgtaagtttgctgt	8	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:55944895G>A	ENST00000373965.2	-	13	1854	c.1461_splice	c.e13+1	p.S487_splice	PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Splice_Site_p.S485_splice|PCDH15_ENST00000361849.3_Splice_Site_p.S480_splice|PCDH15_ENST00000395430.1_Splice_Site_p.S480_splice|PCDH15_ENST00000373955.1_Splice_Site_p.S480_splice|PCDH15_ENST00000395445.1_Splice_Site_p.S487_splice|PCDH15_ENST00000409834.1_Splice_Site_p.S91_splice|PCDH15_ENST00000437009.1_Splice_Site_p.S480_splice|PCDH15_ENST00000373957.3_Splice_Site_p.S458_splice|PCDH15_ENST00000395446.1_Splice_Site_p.S480_splice|PCDH15_ENST00000395438.1_Splice_Site_p.S480_splice|PCDH15_ENST00000395433.1_Splice_Site_p.S458_splice|PCDH15_ENST00000320301.6_Splice_Site_p.S480_splice|PCDH15_ENST00000395432.2_Splice_Site_p.S443_splice	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	480	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.S485L(1)|p.S480L(1)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTCTTTACCGAAAAGGTGTA	0.383										HNSCC(58;0.16)			12	37					0	0	1	0	0	A	55944895	G	A	55944895	5	1	48	1	0	0	0	0	0	0	1	0	11557	1072	37	1	6135	1	PCDH15	10	55944895	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	318353	55944895	79589852	2385	6779										
PCDH15	65217	broad.mit.edu	37	chr10	55955448	55955448	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtatttaacttacatcttCtatgtccttgtccagagcta	5	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:55955448C>A	ENST00000373965.2	-	11	1694	c.1300G>T	c.(1300-1302)Gaa>Taa	p.E434*	PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395440.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000414778.1_Nonsense_Mutation_p.E439*|PCDH15_ENST00000361849.3_Nonsense_Mutation_p.E434*|PCDH15_ENST00000395430.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000373955.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000395445.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000409834.1_Nonsense_Mutation_p.E38*|PCDH15_ENST00000437009.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000373957.3_Nonsense_Mutation_p.E412*|PCDH15_ENST00000395446.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000395438.1_Nonsense_Mutation_p.E434*|PCDH15_ENST00000395433.1_Nonsense_Mutation_p.E412*|PCDH15_ENST00000320301.6_Nonsense_Mutation_p.E434*|PCDH15_ENST00000395432.2_Nonsense_Mutation_p.E397*	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	434	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTACATCTTCTATGTCCTTG	0.373										HNSCC(58;0.16)			9	39					7.48243e-07	8.49459e-07	1	1	0	A	55955448	C	A	55955448	4	1	48	1	0	0	0	0	0	1	0	0	11557	922	32	2	6303	2	PCDH15	10	55955448	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10553	55955448	79579299	2386	6780										
IPMK	253430	broad.mit.edu	37	chr10	59955838	59955838	+	Nonstop_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagactgcaacagaggattCaattgtctaaaatacttcga	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:59955838C>A	ENST00000373935.3	-	6	1572	c.1250G>T	c.(1249-1251)tGa>tTa	p.*417L		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	0						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						ACAGAGGATTCAATTGTCTAA	0.353													24	55					2.79863e-10	3.42475e-10	1	1	0	A	59955838	C	A	59955838	4	1	48	1	0	0	0	0	0	0	0	0	7835	837	29	2	4	2	IPMK	10	59955838	Nonstop_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4000390	59955838	75578909	2387	6781										
PHYHIPL	84457	broad.mit.edu	37	chr10	61004994	61004994	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgagattgccgcagaaaaActttttaaccccaatactaa	5	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:61004994A>G	ENST00000373880.4	+	5	1038	c.774A>G	c.(772-774)aaA>aaG	p.K258K	PHYHIPL_ENST00000373878.3_Silent_p.K232K	NM_032439.3	NP_115815.2	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein-like	258										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(3)|skin(1)|urinary_tract(1)	18						CCGCAGAAAAACTTTTTAACC	0.413													5	48					0	0	1	0	0	G	61004994	A	G	61004994	2	3	48	1	0	0	0	0	0	0	0	1	11914	40	2	4		4	PHYHIPL	10	61004994	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1049156	61004994	74529753	2388	6782										
ANK3	288	broad.mit.edu	37	chr10	61834982	61834982	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggtgtagacaacttaaggGcagagggtgcaaggaacaaa	14	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:61834982G>A	ENST00000280772.1	-	37	5848	c.5657C>T	c.(5656-5658)gCc>gTc	p.A1886V	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1886	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CAACTTAAGGGCAGAGGGTGC	0.433													26	58					0	0	1	0	0	A	61834982	G	A	61834982	3	1	48	1	0	0	0	0	1	0	0	0	618	1203	42	3	7817	3	ANK3	10	61834982	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	829988	61834982	73699765	2389	6783										
ANK3	288	broad.mit.edu	37	chr10	61835651	61835651	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggtgctgctgatgtaataAttgacttaaatggcaaactt	10	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:61835651A>C	ENST00000280772.1	-	37	5179	c.4988T>G	c.(4987-4989)aTt>aGt	p.I1663S	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1663	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGATGTAATAATTGACTTAAA	0.398													24	53					0	0	1	0	0	C	61835651	A	C	61835651	3	2	48	1	0	0	0	0	1	0	0	0	618	101	4	4	8486	4	ANK3	10	61835651	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	669	61835651	73699096	2390	6784										
RHOBTB1	9886	broad.mit.edu	37	chr10	62670691	62670691	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatgatcaccaaaagtatCccaaagcctgagagaaacac	8	10	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:62670691C>T	ENST00000337910.5	-	4	587	c.250G>A	c.(250-252)Gat>Aat	p.D84N	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.D84N	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	84	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					CCAAAAGTATCCCAAAGCCTG	0.463													20	27					0	0	1	0	0	T	62670691	C	T	62670691	3	4	48	1	0	0	0	0	1	0	0	0	13382	855	30	3	1872	3	RHOBTB1	10	62670691	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	835040	62670691	72864056	2391	6785										
RTKN2	219790	broad.mit.edu	37	chr10	63957810	63957810	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctatttctcctggcaggcaGaagttttcgaggagcagcca	11	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:63957810G>A	ENST00000373789.3	-	12	1783	c.1687C>T	c.(1687-1689)Ctg>Ttg	p.L563L	RTKN2_ENST00000395265.1_Intron|RTKN2_ENST00000315289.2_Intron	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	563					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					CTGGCAGGCAGAAGTTTTCGA	0.438													22	52					0	0	1	0	0	A	63957810	G	A	63957810	2	1	48	1	0	0	0	0	0	0	0	1	13774	933	33	3		3	RTKN2	10	63957810	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1287119	63957810	71576937	2392	6786										
RTKN2	219790	broad.mit.edu	37	chr10	64022496	64022496	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactgcatgtaaaacttgatCtttctgagtgctcagagaaa	8	7	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:64022496C>T	ENST00000373789.3	-	2	241	c.145G>A	c.(145-147)Gat>Aat	p.D49N	RTKN2_ENST00000395265.1_Missense_Mutation_p.D49N|RTKN2_ENST00000395260.3_Missense_Mutation_p.D49N	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	49					signal transduction	intracellular		p.D49Y(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AAAACTTGATCTTTCTGAGTG	0.363													12	34					0	0	1	0	0	T	64022496	C	T	64022496	3	4	48	1	0	0	0	0	1	0	0	0	13774	913	32	3	1728	3	RTKN2	10	64022496	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	64686	64022496	71512251	2393	6787										
ZNF365	22891	broad.mit.edu	37	chr10	64136203	64136203	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaactcctgaaaccgggaaAattgcagagcagtggcaacg	12	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:64136203A>C	ENST00000395254.3	+	2	531	c.251A>C	c.(250-252)aAa>aCa	p.K84T	ZNF365_ENST00000466727.1_Intron|ZNF365_ENST00000395255.3_Missense_Mutation_p.K84T|ZNF365_ENST00000410046.3_Missense_Mutation_p.K84T	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	49										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					AAACCGGGAAAATTGCAGAGC	0.458													37	60					0	0	1	0	0	C	64136203	A	C	64136203	3	2	48	1	0	0	0	0	1	0	0	0	17925	14	1	4	253	4	ZNF365	10	64136203	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	113707	64136203	71398544	2394	6788										
JMJD1C	221037	broad.mit.edu	37	chr10	64966708	64966708	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttaataatttctgatacaGaattccctgaattttccatt	4	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:64966708G>T	ENST00000399262.2	-	10	4939	c.4721C>A	c.(4720-4722)tCt>tAt	p.S1574Y	JMJD1C_ENST00000402544.1_Missense_Mutation_p.S1355Y|JMJD1C_ENST00000542921.1_Missense_Mutation_p.S1392Y|JMJD1C_ENST00000399251.1_Missense_Mutation_p.S1355Y	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1574					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTCTGATACAGAATTCCCTGA	0.318													14	38					7.93312e-07	8.98086e-07	1	1	0	T	64966708	G	T	64966708	3	4	48	1	0	0	0	0	1	0	0	0	7993	942	33	2	2969	2	JMJD1C	10	64966708	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	830505	64966708	70568039	2395	6789										
LRRTM3	347731	broad.mit.edu	37	chr10	68687299	68687299	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggcatgatcagactcaaaGaacttcacctggagcacaat	8	11	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:68687299G>T	ENST00000361320.4	+	2	1203	c.625G>T	c.(625-627)Gaa>Taa	p.E209*	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	209						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						CAGACTCAAAGAACTTCACCT	0.453													33	63					3.11337e-16	4.1367e-16	1	1	0	T	68687299	G	T	68687299	4	4	48	1	0	0	0	0	0	1	0	0	9085	943	33	2	631	2	LRRTM3	10	68687299	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3720591	68687299	66847448	2396	6790										
SIRT1	23411	broad.mit.edu	37	chr10	69672420	69672420	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattactgaaaaacctccacGaacacaaaaagaattggctt	5	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:69672420G>A	ENST00000212015.6	+	8	1600	c.1547G>A	c.(1546-1548)cGa>cAa	p.R516Q	SIRT1_ENST00000406900.1_Missense_Mutation_p.R213Q|SIRT1_ENST00000403579.1_Missense_Mutation_p.R213Q|SIRT1_ENST00000432464.1_Missense_Mutation_p.R221Q	NM_012238.4	NP_036370.2	Q96EB6	SIRT1_HUMAN	sirtuin 1	516					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding	p.R516Q(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	14						AAACCTCCACGAACACAAAAA	0.388													25	48					0	0	1	0	0	A	69672420	G	A	69672420	3	1	48	1	0	0	0	0	1	0	0	0	14391	1058	37	1	1577	1	SIRT1	10	69672420	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	985121	69672420	65862327	2397	6791										
MYPN	84665	broad.mit.edu	37	chr10	69881929	69881929	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagcaggctgccagtgaggCggctggtggagacactacac	17	10	0	2	rs143574079	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:69881929C>T	ENST00000358913.5	+	2	1222	c.734C>T	c.(733-735)gCg>gTg	p.A245V	MYPN_ENST00000373675.3_Missense_Mutation_p.A245V|MYPN_ENST00000354393.2_Intron|MYPN_ENST00000540630.1_Missense_Mutation_p.A245V	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	245	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GCCAGTGAGGCGGCTGGTGGA	0.567													19	38					0	0	1	0	0	T	69881929	C	T	69881929	3	4	48	1	0	0	0	0	1	0	0	0	10145	768	27	1	736	1	MYPN	10	69881929	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	209509	69881929	65652818	2398	6792										
MYPN	84665	broad.mit.edu	37	chr10	69935124	69935124	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatacaaagtctcctcaacCagtgaatgatgataacattc	5	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:69935124C>T	ENST00000358913.5	+	12	3097	c.2609C>T	c.(2608-2610)cCa>cTa	p.P870L	MYPN_ENST00000354393.2_Missense_Mutation_p.P595L|MYPN_ENST00000540630.1_Missense_Mutation_p.P870L	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	870						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TCTCCTCAACCAGTGAATGAT	0.423													14	32					0	0	1	0	0	T	69935124	C	T	69935124	3	4	48	1	0	0	0	0	1	0	0	0	10145	594	21	3	2651	3	MYPN	10	69935124	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53195	69935124	65599623	2399	6793										
MYPN	84665	broad.mit.edu	37	chr10	69966634	69966634	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaatgaagccggcatcgtgtCgtgcactgccaggctggata	14	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:69966634C>T	ENST00000358913.5	+	19	4255	c.3767C>T	c.(3766-3768)tCg>tTg	p.S1256L	MYPN_ENST00000354393.2_Missense_Mutation_p.S981L|MYPN_ENST00000540630.1_Missense_Mutation_p.S1256L	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1256	Ig-like 5.|Interaction with ACTN.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GGCATCGTGTCGTGCACTGCC	0.448													12	66					0	0	1	0	0	T	69966634	C	T	69966634	3	4	48	1	0	0	0	0	1	0	0	0	10145	893	31	1	3837	1	MYPN	10	69966634	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31510	69966634	65568113	2400	6794										
PBLD	64081	broad.mit.edu	37	chr10	70045061	70045061	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgagaaggaacactagcttCgaattaggcaaataaaaaag	9	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70045061C>T	ENST00000432941.1	-	9	1000	c.798G>A	c.(796-798)tcG>tcA	p.S266S	PBLD_ENST00000336578.1_Intron|PBLD_ENST00000309049.4_Intron|PBLD_ENST00000495025.1_5'UTR|PBLD_ENST00000358769.2_Intron	NM_001033083.1	NP_001028255.1	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	0					biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						ACACTAGCTTCGAATTAGGCA	0.398													21	35					0	0	1	0	0	T	70045061	C	T	70045061	2	4	48	1	0	0	0	0	0	0	0	1	11535	871	31	1		1	PBLD	10	70045061	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	78427	70045061	65489686	2401	6795										
TET1	80312	broad.mit.edu	37	chr10	70332337	70332337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaagagctggagcagcacGcatgaatttggataggactg	14	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70332337G>A	ENST00000373644.4	+	2	451	c.242G>A	c.(241-243)cGc>cAc	p.R81H		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	81					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding	p.R81H(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						GGAGCAGCACGCATGAATTTG	0.438													38	85					0	0	1	0	0	A	70332337	G	A	70332337	3	1	48	1	0	0	0	0	1	0	0	0	15827	1087	38	1	244	1	TET1	10	70332337	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	287276	70332337	65202410	2402	6796										
TET1	80312	broad.mit.edu	37	chr10	70405909	70405909	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catggttcatcattaacaaaAcaaaagaacccaacccagaa	4	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70405909A>G	ENST00000373644.4	+	4	3632	c.3423A>G	c.(3421-3423)aaA>aaG	p.K1141K		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1141					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CATTAACAAAACAAAAGAACC	0.388													6	55					0	0	1	0	0	G	70405909	A	G	70405909	2	3	48	1	0	0	0	0	0	0	0	1	15827	40	2	4		4	TET1	10	70405909	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	73572	70405909	65128838	2403	6797										
CCAR1	55749	broad.mit.edu	37	chr10	70546342	70546342	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatcacaattaacagagatCtgttaatggcttttgtttat	7	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70546342C>T	ENST00000265872.6	+	21	2892	c.2773C>T	c.(2773-2775)Ctg>Ttg	p.L925L	CCAR1_ENST00000543719.1_Silent_p.L910L|CCAR1_ENST00000535016.1_Silent_p.L910L	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	925					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TAACAGAGATCTGTTAATGGC	0.299													9	17					0	0	1	0	0	T	70546342	C	T	70546342	2	4	48	1	0	0	0	0	0	0	0	1	2748	912	32	3		3	CCAR1	10	70546342	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140433	70546342	64988405	2404	6798										
STOX1	219736	broad.mit.edu	37	chr10	70641820	70641820	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaatacagctcagattgtAgtaacgcaggaatcactttt	8	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70641820A>G	ENST00000298596.6	+	2	500	c.417A>G	c.(415-417)gtA>gtG	p.V139V	STOX1_ENST00000421961.2_Silent_p.V29V|STOX1_ENST00000399165.4_Silent_p.V139V|STOX1_ENST00000399169.4_Silent_p.V139V|STOX1_ENST00000399162.2_Silent_p.V139V	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	139						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						CTCAGATTGTAGTAACGCAGG	0.363													23	44					0	0	1	0	0	G	70641820	A	G	70641820	2	3	48	1	0	0	0	0	0	0	0	1	15374	407	15	4		4	STOX1	10	70641820	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	95478	70641820	64892927	2405	6799										
VPS26A	9559	broad.mit.edu	37	chr10	70928317	70928317	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgagagatgtgaacaaaaAattttcagtaaggtactttt	8	3	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70928317A>C	ENST00000373382.1	+	9	1453	c.800A>C	c.(799-801)aAa>aCa	p.K267T	VPS26A_ENST00000546041.1_Missense_Mutation_p.K250T|VPS26A_ENST00000263559.6_Missense_Mutation_p.K267T|VPS26A_ENST00000541711.1_Missense_Mutation_p.K156T|VPS26A_ENST00000490696.1_3'UTR|VPS26A_ENST00000489794.1_Intron|VPS26A_ENST00000395098.1_Intron			O75436	VP26A_HUMAN	vacuolar protein sorting 26 homolog A (S. pombe)	267					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)	8						GTGAACAAAAAATTTTCAGTA	0.368													28	39					0	0	1	0	0	C	70928317	A	C	70928317	3	2	48	1	0	0	0	0	1	0	0	0	17256	14	1	4	830	4	VPS26A	10	70928317	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	286497	70928317	64606430	2406	6800										
SUPV3L1	6832	broad.mit.edu	37	chr10	70946299	70946299	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttgaatgatatttgcttCggtgcaggcaagtgtttaga	12	4	0	3	rs149476310		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:70946299C>T	ENST00000359655.4	+	3	510	c.450C>T	c.(448-450)ttC>ttT	p.F150F	SUPV3L1_ENST00000483572.1_3'UTR	NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	150					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding	p.F150F(1)		NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ATATTTGCTTCGGTGCAGGCA	0.363													20	45					0	0	1	0	0	T	70946299	C	T	70946299	2	4	48	1	0	0	0	0	0	0	0	1	15457	883	31	1		1	SUPV3L1	10	70946299	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17982	70946299	64588448	2407	6801										
HKDC1	80201	broad.mit.edu	37	chr10	71020933	71020933	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggatgtacttgggggagaTtgtgcggcagatcctgatcg	17	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:71020933T>G	ENST00000354624.5	+	16	2388	c.2255T>G	c.(2254-2256)aTt>aGt	p.I752S	HKDC1_ENST00000395086.2_Missense_Mutation_p.I752S	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	752					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TTGGGGGAGATTGTGCGGCAG	0.527													21	45					0	0	1	0	0	G	71020933	T	G	71020933	3	3	48	1	0	0	0	0	1	0	0	0	7233	1493	52	4	2317	4	HKDC1	10	71020933	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	74634	71020933	64513814	2408	6802										
COL13A1	1305	broad.mit.edu	37	chr10	71640268	71640268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccccgcaggggtcccccGgagacgctgggctgtccatc	13	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:71640268G>A	ENST00000356340.3	+	5	981	c.445G>A	c.(445-447)Gga>Aga	p.G149R	COL13A1_ENST00000520267.1_Intron|COL13A1_ENST00000398973.3_Missense_Mutation_p.G149R|COL13A1_ENST00000398971.3_Missense_Mutation_p.G149R|COL13A1_ENST00000398974.3_Missense_Mutation_p.G137R|COL13A1_ENST00000398972.3_Missense_Mutation_p.G149R|COL13A1_ENST00000398966.3_Missense_Mutation_p.G149R|COL13A1_ENST00000522165.1_Missense_Mutation_p.G149R|COL13A1_ENST00000398968.3_Missense_Mutation_p.G149R|COL13A1_ENST00000398969.3_Intron|COL13A1_ENST00000357811.3_Missense_Mutation_p.G149R|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000398978.3_Missense_Mutation_p.G149R|COL13A1_ENST00000354547.3_Missense_Mutation_p.G149R|COL13A1_ENST00000517713.1_Missense_Mutation_p.G149R|COL13A1_ENST00000398964.3_Intron			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	149	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding	p.G149R(2)		endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	GGGGTCCCCCGGAGACGCTGG	0.622													11	29					0	0	1	0	0	A	71640268	G	A	71640268	3	1	48	1	0	0	0	0	1	0	0	0	3693	1117	39	1	467	1	COL13A1	10	71640268	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	619335	71640268	63894479	2409	6803										
PRF1	5551	broad.mit.edu	37	chr10	72360548	72360548	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccagccatgcaccaggcacGaacttgtggctgcgcttgca	12	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:72360548G>A	ENST00000441259.1	-	2	271	c.111C>T	c.(109-111)ttC>ttT	p.F37F	PRF1_ENST00000373209.2_Silent_p.F37F	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	37	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						CACCAGGCACGAACTTGTGGC	0.687			M			"various leukaemia, lymphoma"	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				7	29					0	0	1	0	0	A	72360548	G	A	72360548	2	1	48	1	0	0	0	0	0	0	0	1	12529	1049	37	1		1	PRF1	10	72360548	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	720280	72360548	63174199	2410	6804										
ADAMTS14	140766	broad.mit.edu	37	chr10	72517751	72517751	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggagagggcatccagcagCggcaggtggtgtgcaggacc	19	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:72517751C>T	ENST00000373208.1	+	20	2980	c.2980C>T	c.(2980-2982)Cgg>Tgg	p.R994W	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.R991W	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	991	TSP type-1 4.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CATCCAGCAGCGGCAGGTGGT	0.652													19	46					0	0	1	0	0	T	72517751	C	T	72517751	3	4	48	1	0	0	0	0	1	0	0	0	258	759	27	1	3058	1	ADAMTS14	10	72517751	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	157203	72517751	63016996	2411	6805										
CDH23	64072	broad.mit.edu	37	chr10	73442306	73442306	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccccctctcaacagcaccGtccctgtcaccatcgaggtg	7	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:73442306G>A	ENST00000224721.6	+	17	1983	c.1978G>A	c.(1978-1980)Gtc>Atc	p.V660I	CDH23_ENST00000299366.7_Missense_Mutation_p.V700I	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	655	Cadherin 6.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CAACAGCACCGTCCCTGTCAC	0.552													5	23					0	0	1	0	0	A	73442306	G	A	73442306	3	1	48	1	0	0	0	0	1	0	0	0	3130	1145	40	1	2256	1	CDH23	10	73442306	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	924555	73442306	62092441	2412	6806										
CDH23	64072	broad.mit.edu	37	chr10	73544715	73544715	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgctgaacctgcccatgaAcatcaccatcagcgagaaca	8	14	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:73544715A>G	ENST00000224721.6	+	42	5590	c.5585A>G	c.(5584-5586)aAc>aGc	p.N1862S		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1857	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CTGCCCATGAACATCACCATC	0.597													27	62					0	0	1	0	0	G	73544715	A	G	73544715	3	3	48	1	0	0	0	0	1	0	0	0	3130	43	2	4	6081	4	CDH23	10	73544715	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	102409	73544715	61990032	2413	6807										
ECD	11319	broad.mit.edu	37	chr10	74916109	74916109	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatgtgctgtgattatatTcaatgcttgtggaattgttg	11	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:74916109T>G	ENST00000372979.4	-	5	720	c.514A>C	c.(514-516)Aat>Cat	p.N172H	ECD_ENST00000430082.1_Missense_Mutation_p.N172H|ECD_ENST00000454759.1_Missense_Mutation_p.N172H	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	172					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					GTGATTATATTCAATGCTTGT	0.403													32	36					0	0	1	0	0	G	74916109	T	G	74916109	3	3	48	1	0	0	0	0	1	0	0	0	4914	1783	62	4	1563	4	ECD	10	74916109	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1371394	74916109	60618638	2414	6808										
PPP3CB	5532	broad.mit.edu	37	chr10	75234763	75234763	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtgcttgggtatagaatcTtcagaacccataaatataag	8	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:75234763T>G	ENST00000360663.5	-	4	548	c.437A>C	c.(436-438)aAg>aCg	p.K146T	PPP3CB_ENST00000342558.3_Missense_Mutation_p.K146T|PPP3CB_ENST00000394829.2_Missense_Mutation_p.K146T|PPP3CB_ENST00000545874.1_Missense_Mutation_p.K60T|PPP3CB_ENST00000394822.2_Missense_Mutation_p.K164T|PPP3CB_ENST00000394828.2_Missense_Mutation_p.K146T			P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta isozyme	146	Catalytic.									breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(7)|skin(1)|urinary_tract(1)	22	Prostate(51;0.0119)					GTATAGAATCTTCAGAACCCA	0.348													4	41					0	0	1	0	0	G	75234763	T	G	75234763	3	3	48	1	0	0	0	0	1	0	0	0	12446	1609	56	4	1184	4	PPP3CB	10	75234763	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	318654	75234763	60299984	2415	6809										
MYOZ1	58529	broad.mit.edu	37	chr10	75393727	75393728	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggtcaatgccaagttccaINSttttttgctgggggtcaacc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:75393727_75393728insT	ENST00000359322.4	-	5	962_963	c.598_599insA	c.(598-600)ggafs	p.G200fs		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	200					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					GCCAAGTTCCATTTTTTGCTGG	0.515													25	69	---	---	---	---						T	75393728	-	T	75393727	7	5	48	1	0	1	1	0	0	0	0	0	10142	217	8	0	308	0	MYOZ1	10	75393727	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	158964	75393727	60141020	2416	6810										
PLAU	5328	broad.mit.edu	37	chr10	75673107	75673107	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgggcctaaagctgcttgTccaagagtgcatggtgcatg	15	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:75673107T>C	ENST00000446342.1	+	5	859	c.377T>C	c.(376-378)gTc>gCc	p.V126A	C10orf55_ENST00000412307.2_Intron|PLAU_ENST00000494287.1_3'UTR|C10orf55_ENST00000409178.1_Intron|PLAU_ENST00000372764.3_Missense_Mutation_p.V143A|PLAU_ENST00000372762.4_Missense_Mutation_p.V107A	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	143	Kringle.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	AAGCTGCTTGTCCAAGAGTGC	0.542													41	73					0	0	1	0	0	C	75673107	T	C	75673107	3	2	48	1	0	0	0	0	1	0	0	0	12069	1667	58	4	484	4	PLAU	10	75673107	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	279380	75673107	59861640	2417	6811										
VCL	7414	broad.mit.edu	37	chr10	75830449	75830449	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgagaatgcttgcaccaaGcttgtccaggcagctcagat	11	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:75830449G>A	ENST00000211998.4	+	3	355	c.261G>A	c.(259-261)aaG>aaA	p.K87K	VCL_ENST00000417648.2_Silent_p.K87K|VCL_ENST00000478896.2_Intron|VCL_ENST00000372755.3_Silent_p.K87K	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	87	N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					CTTGCACCAAGCTTGTCCAGG	0.468													31	65					0	0	1	0	0	A	75830449	G	A	75830449	2	1	48	1	0	0	0	0	0	0	0	1	17198	962	34	3		3	VCL	10	75830449	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	157342	75830449	59704298	2418	6812										
DUSP13	0	broad.mit.edu	37	chr10	76868869	76868869	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggatgctggggcaaggcGtggctttgtcctctcccccc	13	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:76868869G>A	ENST00000491677.2	-	0	101				DUSP13_ENST00000607131.1_De_novo_Start_OutOfFrame|DUSP13_ENST00000372702.3_Missense_Mutation_p.T16M|DUSP13_ENST00000607009.1_5'UTR|DUSP13_ENST00000372700.3_Missense_Mutation_p.T16M	NM_001007271.1	NP_001007272.1	Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13							cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GGGGCAAGGCGTGGCTTTGTC	0.627													19	33					0	0	1	0	0	A	76868869	G	A	76868869	1	1	48	1	0	0	0	0	0	0	0	0	4839	1145	40	1		1	DUSP13	10	76868869	Translation_Start_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1038420	76868869	58665878	2419	6813										
KCNMA1	3778	broad.mit.edu	37	chr10	78868324	78868324	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagggacgtagctggcaaAcatggcctgagaagatagga	14	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:78868324A>G	ENST00000286627.5	-	9	2090	c.1138T>C	c.(1138-1140)Ttt>Ctt	p.F380L	KCNMA1_ENST00000372443.1_Missense_Mutation_p.F380L|KCNMA1_ENST00000286628.8_Missense_Mutation_p.F380L|KCNMA1_ENST00000404771.3_Missense_Mutation_p.F380L|KCNMA1_ENST00000404857.1_Missense_Mutation_p.F380L|KCNMA1_ENST00000372440.1_Missense_Mutation_p.F380L|KCNMA1_ENST00000354353.5_Missense_Mutation_p.F380L|KCNMA1_ENST00000406533.3_Missense_Mutation_p.F380L	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	380					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TAGCTGGCAAACATGGCCTGA	0.468													17	34					0	0	1	0	0	G	78868324	A	G	78868324	3	3	48	1	0	0	0	0	1	0	0	0	8116	43	2	4	2824	4	KCNMA1	10	78868324	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1999455	78868324	56666423	2420	6814										
DLG5	9231	broad.mit.edu	37	chr10	79595622	79595622	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagagccttgcactgctttCgaaggatttcaacctccttg	8	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:79595622C>T	ENST00000372391.2	-	8	1501	c.1496G>A	c.(1495-1497)cGa>cAa	p.R499Q	DLG5_ENST00000372388.2_Missense_Mutation_p.R499Q	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	499					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GCACTGCTTTCGAAGGATTTC	0.597													20	52					0	0	1	0	0	T	79595622	C	T	79595622	3	4	48	1	0	0	0	0	1	0	0	0	4586	884	31	1	4363	1	DLG5	10	79595622	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	727298	79595622	55939125	2421	6815										
NRG3	10718	broad.mit.edu	37	chr10	84745314	84745314	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcagaacgagaggcgcaaTttgtcttaagaaatgaaata	9	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:84745314T>A	ENST00000372142.2	+	11	1727	c.1453T>A	c.(1453-1455)Ttt>Att	p.F485I	NRG3_ENST00000556918.1_Missense_Mutation_p.F512I|NRG3_ENST00000372141.2_Missense_Mutation_p.F682I|NRG3_ENST00000404576.2_Missense_Mutation_p.F486I|NRG3_ENST00000545131.1_Missense_Mutation_p.F332I|NRG3_ENST00000537893.1_Missense_Mutation_p.F332I|NRG3_ENST00000404547.1_Missense_Mutation_p.F706I	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	706					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AGAGGCGCAATTTGTCTTAAG	0.468													32	51					0	0	1	0	0	A	84745314	T	A	84745314	3	1	48	1	0	0	0	0	1	0	0	0	10696	1493	52	4	2322	4	NRG3	10	84745314	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5149692	84745314	50789433	2422	6816										
GRID1	2894	broad.mit.edu	37	chr10	87362273	87362273	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctctgctctggcagaaaGgtgctgaccgagagctgggt	15	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:87362273G>T	ENST00000327946.7	-	16	2872	c.2787C>A	c.(2785-2787)acC>acA	p.T929T	GRID1_ENST00000536331.1_Silent_p.T500T|GRID1_ENST00000552278.2_5'UTR	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	929						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CTGGCAGAAAGGTGCTGACCG	0.662										Multiple Myeloma(13;0.14)			7	56					0.00198382	0.00207034	1	1	0	T	87362273	G	T	87362273	2	4	48	1	0	0	0	0	0	0	0	1	6811	987	35	5		5	GRID1	10	87362273	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2616959	87362273	48172474	2423	6817										
GRID1	2894	broad.mit.edu	37	chr10	87484239	87484239	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacacaaatatcagcacaccAaccacagggatggctgctgc	8	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:87484239A>G	ENST00000327946.7	-	11	1813	c.1728T>C	c.(1726-1728)gtT>gtC	p.V576V	GRID1_ENST00000536331.1_Silent_p.V147V	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	576						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCAGCACACCAACCACAGGGA	0.532										Multiple Myeloma(13;0.14)			24	51					0	0	1	0	0	G	87484239	A	G	87484239	2	3	48	1	0	0	0	0	0	0	0	1	6811	117	5	4		4	GRID1	10	87484239	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	121966	87484239	48050508	2424	6818										
GRID1	2894	broad.mit.edu	37	chr10	87614322	87614322	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaaactggacatagggattCgaactgtcctcccgaaactc	8	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:87614322C>T	ENST00000327946.7	-	8	1249	c.1164G>A	c.(1162-1164)tcG>tcA	p.S388S		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	388						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CATAGGGATTCGAACTGTCCT	0.488										Multiple Myeloma(13;0.14)			29	53					0	0	1	0	0	T	87614322	C	T	87614322	2	4	48	1	0	0	0	0	0	0	0	1	6811	871	31	1		1	GRID1	10	87614322	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	130083	87614322	47920425	2425	6819										
WAPAL	23063	broad.mit.edu	37	chr10	88277381	88277381	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcatcatcttctacaattCggtttgtgctcttttctttc	5	10	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:88277381C>T	ENST00000298767.5	-	2	918	c.446G>A	c.(445-447)cGa>cAa	p.R149Q		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	149	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						TTCTACAATTCGGTTTGTGCT	0.368													16	51					0	0	1	0	0	T	88277381	C	T	88277381	3	4	48	1	0	0	0	0	1	0	0	0	17307	884	31	1	3198	1	WAPAL	10	88277381	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	663059	88277381	47257366	2426	6820										
SNCG	6623	broad.mit.edu	37	chr10	88719763	88719763	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgtcctcccatagtggccGagaagaccaaggagcaggcc	13	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:88719763G>A	ENST00000372017.3	+	3	211	c.169G>A	c.(169-171)Gag>Aag	p.E57K	SNCG_ENST00000483064.1_3'UTR|SNCG_ENST00000348795.4_Missense_Mutation_p.R74Q	NM_003087.2	NP_003078.2	O76070	SYUG_HUMAN	synuclein, gamma (breast cancer-specific protein 1)	57	4 X 11 AA tandem repeats of [EGSA]-K-T-K- [EQ]-[GQ]-V-X(4).					microtubule organizing center|perinuclear region of cytoplasm|spindle	protein binding			endometrium(1)|skin(1)	2						CATAGTGGCCGAGAAGACCAA	0.667													7	9					0	0	1	0	0	A	88719763	G	A	88719763	3	1	48	1	0	0	0	0	1	0	0	0	14896	1059	37	1	179	1	SNCG	10	88719763	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	442382	88719763	46814984	2427	6821										
AGAP11	119385	broad.mit.edu	37	chr10	88761434	88761434	+	RNA	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacaatacagctcgtgttcGacaatattccttgatggcag	8	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:88761434G>A	ENST00000444431.1	+	0	2564				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GCTCGTGTTCGACAATATTCC	0.383													34	57					0	0	1	0	0	A	88761434	G	A	88761434	1	1	48	0	1	0	0	0	0	0	0	0	366	1073	37	1		1	AGAP11	10	88761434	RNA	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	41671	88761434	46773313	2428	6822										
AGAP11	119385	broad.mit.edu	37	chr10	88768826	88768826	+	RNA	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcactgctgaggaagaagaaGaaaagtttatgattgtgtcc	12	5	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:88768826G>T	ENST00000444431.1	+	0	3426				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GGAAGAAGAAGAAAAGTTTAT	0.493													65	122					4.09106e-26	5.77846e-26	1	1	0	T	88768826	G	T	88768826	1	4	48	0	1	0	0	0	0	0	0	0	366	943	33	2		2	AGAP11	10	88768826	RNA	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7392	88768826	46765921	2429	6823										
PTEN	5728	broad.mit.edu	37	chr10	89692905	89692905	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtaaagctggaaagggacGaactggtgtaatgatatgtg	14	4	0	1	rs121913292		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:89692905G>A	ENST00000371953.3	+	5	1746	c.389G>A	c.(388-390)cGa>cAa	p.R130Q		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).|R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130Q(62)|p.0?(37)|p.R130fs*4(13)|p.R130L(12)|p.R130P(7)|p.?(5)|p.R55fs*1(5)|p.K128_R130del(3)|p.Y27fs*1(2)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131fs*50(1)|p.F56fs*2(1)|p.K128fs*47(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGAAAGGGACGAACTGGTGTA	0.403	R130Q(JHUEM1_ENDOMETRIUM)|R130Q(MDAPCA2B_PROSTATE)|R130Q(MFE296_ENDOMETRIUM)|R130fs*4(AN3CA_ENDOMETRIUM)	31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			39	63					0	0	1	0	0	A	89692905	G	A	89692905	3	1	48	1	0	0	0	0	1	0	0	0	12786	1058	37	1	407	1	PTEN	10	89692905	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	924079	89692905	45841842	2430	6824										
PTEN	5728	broad.mit.edu	37	chr10	89711983	89711983	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttcacaagatgatgtttGaaactattccaatgttcagt	7	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:89711983G>T	ENST00000371953.3	+	6	1958	c.601G>T	c.(601-603)Gaa>Taa	p.E201*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	201	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.?(4)|p.G165fs*9(3)|p.Y27fs*1(2)|p.F200fs*21(2)|p.G165_*404del(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GATGATGTTTGAAACTATTCC	0.373		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			40	62					1.07121e-22	1.49242e-22	1	1	0	T	89711983	G	T	89711983	4	4	48	1	0	0	0	0	0	1	0	0	12786	1291	45	2	623	2	PTEN	10	89711983	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19078	89711983	45822764	2431	6825										
PTEN	5728	broad.mit.edu	37	chr10	89720871	89720871	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgatacttttctccaaattTtaaggtcagttaaattaaac	4	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:89720871T>G	ENST00000371953.3	+	8	2379	c.1022T>G	c.(1021-1023)tTt>tGt	p.F341C	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	341	C2 tensin-type.		F -> V (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.F341C(1)|p.W274_F341del(1)|p.S338fs*1(1)|p.D326_K342del(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCTCCAAATTTTAAGGTCAGT	0.338		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			16	33					0	0	1	0	0	G	89720871	T	G	89720871	3	3	48	1	0	0	0	0	1	0	0	0	12786	1841	64	4	1052	4	PTEN	10	89720871	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8888	89720871	45813876	2432	6826										
LIPJ	142910	broad.mit.edu	37	chr10	90356596	90356596	+	Missense_Mutation	SNP	T	T	G													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaacctcatttaaaaaatTcattggttcaaagctgtgtc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:90356596T>G	ENST00000371939.3	+	8	940	c.626T>G	c.(625-627)tTc>tGc	p.F209C		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	209					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		TTTAAAAAATTCATTGGTTCA	0.308													13	47					0	0	1	0	0	G	90356596	T	G	90356596	3	3	48	1	0	0	0	0	1	0	0	0	8866	1783	62	4	648	4	LIPJ	10	90356596	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	635725	90356596	45178151	2433	6827	21	2								
LIPJ	142910	broad.mit.edu	37	chr10	90356597	90356597	+	Silent	SNP	C	C	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaacctcatttaaaaaattCattggttcaaagctgtgtcc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:90356597C>T	ENST00000371939.3	+	8	941	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	209					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		TTAAAAAATTCATTGGTTCAA	0.308													14	46					0	0	1	0	0	T	90356597	C	T	90356597	2	4	48	1	0	0	0	0	0	0	0	1	8866	825	29	3		3	LIPJ	10	90356597	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1	90356597	45178150	2434	6828	21	2								
LIPK	643414	broad.mit.edu	37	chr10	90497470	90497470	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaagtgtgcaatcgaaagCtattccgtcgtatttgcagc	9	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:90497470C>T	ENST00000404190.1	+	6	748	c.748C>T	c.(748-750)Cta>Tta	p.L250L		NM_001080518.1	NP_001073987.1	Q5VXJ0	LIPK_HUMAN	lipase, family member K	250					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	12		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		CAATCGAAAGCTATTCCGTCG	0.383													30	72					0	0	1	0	0	T	90497470	C	T	90497470	2	4	48	1	0	0	0	0	0	0	0	1	8867	796	28	3		3	LIPK	10	90497470	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140873	90497470	45037277	2435	6829										
IFIT2	3433	broad.mit.edu	37	chr10	91065810	91065810	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggagaaaactccttggatGattttgaagacaaagtattt	10	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91065810G>T	ENST00000371826.3	+	2	266	c.97G>T	c.(97-99)Gat>Tat	p.D33Y	LIPA_ENST00000487618.1_Intron|LIPA_ENST00000371837.1_Intron	NM_001547.4	NP_001538.4	P09913	IFIT2_HUMAN	interferon-induced protein with tetratricopeptide repeats 2	33					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	12		Colorectal(252;0.0161)				CTCCTTGGATGATTTTGAAGA	0.433													20	39					4.96729e-08	5.79844e-08	1	1	0	T	91065810	G	T	91065810	3	4	48	1	0	0	0	0	1	0	0	0	7566	1290	45	2	103	2	IFIT2	10	91065810	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	568340	91065810	44468937	2436	6830										
IFIT1	3434	broad.mit.edu	37	chr10	91162430	91162430	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagctttcaaatcccttccGctatagaatggagtgtccag	9	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91162430G>A	ENST00000546318.1	+	2	1592	c.305G>A	c.(304-306)cGc>cAc	p.R102H	IFIT1_ENST00000371804.3_Missense_Mutation_p.R133H|LIPA_ENST00000371837.1_Intron	NM_001270928.1|NM_001270929.1|NM_001270930.1	NP_001257857.1|NP_001257858.1|NP_001257859.1	P09914	IFIT1_HUMAN	interferon-induced protein with tetratricopeptide repeats 1	133					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	15						AATCCCTTCCGCTATAGAATG	0.473													21	51					0	0	1	0	0	A	91162430	G	A	91162430	3	1	48	1	0	0	0	0	1	0	0	0	7564	1087	38	1	404	1	IFIT1	10	91162430	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	96620	91162430	44372317	2437	6831										
IFIT5	24138	broad.mit.edu	37	chr10	91178049	91178049	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggacattttccggaaagctCttcgtctggagaacataacc	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91178049C>A	ENST00000371795.4	+	2	1306	c.1093C>A	c.(1093-1095)Ctt>Att	p.L365I	IFIT5_ENST00000416601.1_Missense_Mutation_p.L317I	NM_012420.2	NP_036552.1	Q13325	IFIT5_HUMAN	interferon-induced protein with tetratricopeptide repeats 5	365							binding			endometrium(1)|large_intestine(4)|lung(4)	9						CCGGAAAGCTCTTCGTCTGGA	0.458													7	54					0.00198382	0.00207034	1	1	0	A	91178049	C	A	91178049	3	1	48	1	0	0	0	0	1	0	0	0	7568	913	32	2	1099	2	IFIT5	10	91178049	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15619	91178049	44356698	2438	6832										
KIF20B	9585	broad.mit.edu	37	chr10	91468967	91468967	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatctccaggtttgtcttcGaataagaccatttacacagt	6	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91468967G>A	ENST00000416354.1	+	3	263	c.191G>A	c.(190-192)cGa>cAa	p.R64Q	KIF20B_ENST00000394289.2_Missense_Mutation_p.R64Q|KIF20B_ENST00000371728.3_Missense_Mutation_p.R64Q|KIF20B_ENST00000260753.4_Missense_Mutation_p.R64Q			Q96Q89	KI20B_HUMAN	kinesin family member 20B	64	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						GTTTGTCTTCGAATAAGACCA	0.294													9	44					0	0	1	0	0	A	91468967	G	A	91468967	3	1	48	1	0	0	0	0	1	0	0	0	8328	1058	37	1	197	1	KIF20B	10	91468967	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	290918	91468967	44065780	2439	6833										
KIF20B	9585	broad.mit.edu	37	chr10	91470748	91470748	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatattggcattctgcctcGaactttgaatgtattatttg	7	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91470748G>A	ENST00000416354.1	+	6	593	c.521G>A	c.(520-522)cGa>cAa	p.R174Q	KIF20B_ENST00000394289.2_Missense_Mutation_p.R174Q|KIF20B_ENST00000371728.3_Missense_Mutation_p.R174Q|KIF20B_ENST00000260753.4_Missense_Mutation_p.R174Q			Q96Q89	KI20B_HUMAN	kinesin family member 20B	174	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						ATTCTGCCTCGAACTTTGAAT	0.328													6	21					0	0	1	0	0	A	91470748	G	A	91470748	3	1	48	1	0	0	0	0	1	0	0	0	8328	1058	37	1	539	1	KIF20B	10	91470748	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1781	91470748	44063999	2440	6834										
KIF20B	9585	broad.mit.edu	37	chr10	91478603	91478603	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatgaaacactcaatgtaTtgaagttctccgccattgca	7	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91478603T>C	ENST00000416354.1	+	12	1480	c.1408T>C	c.(1408-1410)Ttg>Ctg	p.L470L	KIF20B_ENST00000394289.2_Silent_p.L470L|KIF20B_ENST00000371728.3_Silent_p.L470L|KIF20B_ENST00000260753.4_Silent_p.L470L			Q96Q89	KI20B_HUMAN	kinesin family member 20B	470					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						ACTCAATGTATTGAAGTTCTC	0.254													14	20					0	0	1	0	0	C	91478603	T	C	91478603	2	2	48	1	0	0	0	0	0	0	0	1	8328	1490	52	4		4	KIF20B	10	91478603	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7855	91478603	44056144	2441	6835										
KIF20B	9585	broad.mit.edu	37	chr10	91479274	91479274	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacagtaattcaaacagtaaAatattaaatgtaaaaagagc	6	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91479274A>C	ENST00000416354.1	+	13	1605	c.1533A>C	c.(1531-1533)aaA>aaC	p.K511N	KIF20B_ENST00000394289.2_Missense_Mutation_p.K511N|KIF20B_ENST00000371728.3_Missense_Mutation_p.K511N|KIF20B_ENST00000260753.4_Missense_Mutation_p.K511N			Q96Q89	KI20B_HUMAN	kinesin family member 20B	511					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						CAAACAGTAAAATATTAAATG	0.353													11	20					0	0	1	0	0	C	91479274	A	C	91479274	3	2	48	1	0	0	0	0	1	0	0	0	8328	11	1	4	1579	4	KIF20B	10	91479274	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	671	91479274	44055473	2442	6836										
KIF20B	9585	broad.mit.edu	37	chr10	91488915	91488915	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagaatcaaagaattaaaGaattgataaatataattgat	5	3	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91488915G>T	ENST00000416354.1	+	18	2374	c.2302G>T	c.(2302-2304)Gaa>Taa	p.E768*	KIF20B_ENST00000394289.2_Nonsense_Mutation_p.E768*|KIF20B_ENST00000371728.3_Nonsense_Mutation_p.E768*|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000260753.4_Nonsense_Mutation_p.E728*			Q96Q89	KI20B_HUMAN	kinesin family member 20B	768					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						AAGAATTAAAGAATTGATAAA	0.239													9	21					0.0477658	0.0484551	1	1	0	T	91488915	G	T	91488915	4	4	48	1	0	0	0	0	0	1	0	0	8328	943	33	2	2248	2	KIF20B	10	91488915	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9641	91488915	44045832	2443	6837										
KIF20B	9585	broad.mit.edu	37	chr10	91528529	91528529	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcatctaagaaaacatattCtttacggagtcaggcatcca	6	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:91528529C>A	ENST00000416354.1	+	31	5288	c.5216C>A	c.(5215-5217)tCt>tAt	p.S1739Y	KIF20B_ENST00000371728.3_Missense_Mutation_p.S1709Y|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000260753.4_Missense_Mutation_p.S1669Y			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1709	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						AAAACATATTCTTTACGGAGT	0.358													22	30					6.33239e-15	8.29613e-15	1	1	0	A	91528529	C	A	91528529	3	1	48	1	0	0	0	0	1	0	0	0	8328	913	32	2	5124	2	KIF20B	10	91528529	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	39614	91528529	44006218	2444	6838										
HECTD2	143279	broad.mit.edu	37	chr10	93258717	93258717	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccaatcaaaatagaaaagGtaagttaataccctttttaa	4	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:93258717G>A	ENST00000446394.1	+	18	1955		c.e18+1		HECTD2_ENST00000536715.1_Splice_Site|HECTD2_ENST00000371667.1_Splice_Site|HECTD2_ENST00000298068.5_Splice_Site			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						AATAGAAAAGGTAAGTTAATA	0.274													12	20					0	0	1	0	0	A	93258717	G	A	93258717	5	1	48	1	0	0	0	0	0	0	1	0	7080	1275	44	3	1934	3	HECTD2	10	93258717	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1730188	93258717	42276030	2445	6839										
KIF11	3832	broad.mit.edu	37	chr10	94369267	94369267	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgatgaatgcatactctagGtaagaaagccatagtctctt	8	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:94369267G>T	ENST00000260731.3	+	6	788		c.e6+1			NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11						blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CATACTCTAGGTAAGAAAGCC	0.413													82	180					3.3814e-41	4.88657e-41	1	1	0	T	94369267	G	T	94369267	5	4	48	1	0	0	0	0	0	0	1	0	8313	1275	44	5	721	5	KIF11	10	94369267	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1110550	94369267	41165480	2446	6840										
KIF11	3832	broad.mit.edu	37	chr10	94397195	94397195	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctcagtatactgtgtaacAatctacatgaactacaagaa	5	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:94397195A>G	ENST00000260731.3	+	16	2143	c.2053A>G	c.(2053-2055)Aat>Gat	p.N685D		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	685					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACTGTGTAACAATCTACATGA	0.338													12	19					0	0	1	0	0	G	94397195	A	G	94397195	3	3	48	1	0	0	0	0	1	0	0	0	8313	130	5	4	2115	4	KIF11	10	94397195	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	27928	94397195	41137552	2447	6841										
EXOC6	54536	broad.mit.edu	37	chr10	94816756	94816756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccagcttctaagtaccttCgggtgaatccaaacacagcc	8	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:94816756C>T	ENST00000371552.4	+	21	2259	c.2230C>T	c.(2230-2232)Cgg>Tgg	p.R744W	EXOC6_ENST00000443748.2_Missense_Mutation_p.R646W|EXOC6_ENST00000260762.6_Missense_Mutation_p.R749W|EXOC6_ENST00000371547.4_Missense_Mutation_p.R765W	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	749					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TAAGTACCTTCGGGTGAATCC	0.403													24	38					0	0	1	0	0	T	94816756	C	T	94816756	3	4	48	1	0	0	0	0	1	0	0	0	5335	875	31	1	2417	1	EXOC6	10	94816756	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	419561	94816756	40717991	2448	6842										
CEP55	55165	broad.mit.edu	37	chr10	95262876	95262876	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtttatgtctagaaaattCgagtccttgaggctgagaag	11	5	1	3	rs146596670		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:95262876C>T	ENST00000371485.3	+	3	494	c.190C>T	c.(190-192)Cga>Tga	p.R64*		NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	64					cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				CTAGAAAATTCGAGTCCTTGA	0.368													19	22					0	0	1	0	0	T	95262876	C	T	95262876	4	4	48	1	0	0	0	0	0	1	0	0	3277	876	31	1	196	1	CEP55	10	95262876	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	446120	95262876	40271871	2449	6843										
CEP55	55165	broad.mit.edu	37	chr10	95263099	95263099	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgtctgctgcaacctcacGaattgctgaacttgaaagca	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:95263099G>A	ENST00000371485.3	+	3	717	c.413G>A	c.(412-414)cGa>cAa	p.R138Q		NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	138					cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				GCAACCTCACGAATTGCTGAA	0.393													20	41					0	0	1	0	0	A	95263099	G	A	95263099	3	1	48	1	0	0	0	0	1	0	0	0	3277	1058	37	1	419	1	CEP55	10	95263099	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	223	95263099	40271648	2450	6844										
FRA10AC1	118924	broad.mit.edu	37	chr10	95445014	95445014	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaacttacttaatttaacaAgtgcatttctcttctcacca	2	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:95445014A>C	ENST00000359204.4	-	9	811	c.614T>G	c.(613-615)cTt>cGt	p.L205R	FRA10AC1_ENST00000536233.1_Missense_Mutation_p.L205R|FRA10AC1_ENST00000371430.2_Missense_Mutation_p.L205R|FRA10AC1_ENST00000394100.2_Missense_Mutation_p.L205R	NM_145246.4	NP_660289.2	Q70Z53	F10C1_HUMAN	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	205	Lys-rich.					nucleus	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|urinary_tract(1)	14						TAATTTAACAAGTGCATTTCT	0.264													17	62					0	0	1	0	0	C	95445014	A	C	95445014	3	2	48	1	0	0	0	0	1	0	0	0	6074	72	3	4	357	4	FRA10AC1	10	95445014	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	181915	95445014	40089733	2451	6845										
FRA10AC1	118924	broad.mit.edu	37	chr10	95459799	95459799	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacttacctttttttccttTtgctggattctccacagcgt	5	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:95459799T>G	ENST00000359204.4	-	2	262	c.65A>C	c.(64-66)aAa>aCa	p.K22T	FRA10AC1_ENST00000536233.1_Missense_Mutation_p.K22T|FRA10AC1_ENST00000371430.2_Missense_Mutation_p.K22T|FRA10AC1_ENST00000394100.2_Missense_Mutation_p.K22T	NM_145246.4	NP_660289.2	Q70Z53	F10C1_HUMAN	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	22						nucleus	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|urinary_tract(1)	14						TTTTTTCCTTTTGCTGGATTC	0.299													13	15					0	0	1	0	0	G	95459799	T	G	95459799	3	3	48	1	0	0	0	0	1	0	0	0	6074	1841	64	4	934	4	FRA10AC1	10	95459799	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	14785	95459799	40074948	2452	6846										
PLCE1	51196	broad.mit.edu	37	chr10	96030304	96030304	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacctgccaatcatcatatCgattgagaaccactgttcat	6	11	3	2	rs121912605		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:96030304C>A	ENST00000260766.3	+	18	5085	c.4451C>A	c.(4450-4452)tCg>tAg	p.S1484*	PLCE1_ENST00000371380.2_Nonsense_Mutation_p.S1484*|PLCE1_ENST00000371385.3_Nonsense_Mutation_p.S1176*|PLCE1_ENST00000371375.1_Nonsense_Mutation_p.S1176*	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1484	PI-PLC X-box.		S -> L (in NPHS3; gives rise to focal segmental glomerulosclerosis rather than diffuse mesangial sclerosis).		activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				ATCATCATATCGATTGAGAAC	0.438													31	58					5.60225e-13	7.13348e-13	1	1	0	A	96030304	C	A	96030304	4	1	48	1	0	0	0	0	0	1	0	0	12081	893	31	2	4803	2	PLCE1	10	96030304	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	570505	96030304	39504443	2453	6847										
PLCE1	51196	broad.mit.edu	37	chr10	96073057	96073057	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgcagactcacagagtcaCggtgcatggggtcccagggc	14	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:96073057C>T	ENST00000260766.3	+	28	6684	c.6050C>T	c.(6049-6051)aCg>aTg	p.T2017M	PLCE1_ENST00000371380.2_Missense_Mutation_p.T2017M|PLCE1_ENST00000371385.3_Missense_Mutation_p.T1709M|PLCE1_ENST00000371375.1_Missense_Mutation_p.T1709M	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	2017	Ras-associating 1.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CACAGAGTCACGGTGCATGGG	0.458													30	66					0	0	1	0	0	T	96073057	C	T	96073057	3	4	48	1	0	0	0	0	1	0	0	0	12081	536	19	1	6442	1	PLCE1	10	96073057	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	42753	96073057	39461690	2454	6848										
HELLS	3070	broad.mit.edu	37	chr10	96354558	96354558	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatactatcgatcagaaaaTtgtggaaagagcagctgcta	9	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:96354558T>G	ENST00000348459.5	+	19	2300	c.2195T>G	c.(2194-2196)aTt>aGt	p.I732S	HELLS_ENST00000371332.4_Missense_Mutation_p.I778S|HELLS_ENST00000239026.6_3'UTR|RP11-119K6.6_ENST00000432120.1_RNA|HELLS_ENST00000394036.1_3'UTR|HELLS_ENST00000394045.1_Missense_Mutation_p.I634S	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	732	Helicase C-terminal.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GATCAGAAAATTGTGGAAAGA	0.373													4	26					0	0	1	0	0	G	96354558	T	G	96354558	3	3	48	1	0	0	0	0	1	0	0	0	7086	1493	52	4	2269	4	HELLS	10	96354558	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	281501	96354558	39180189	2455	6849										
CYP2C9	1559	broad.mit.edu	37	chr10	96708977	96708977	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaaaaagtaaaagaacaccAagaatcaatggacatgaaca	8	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:96708977A>C	ENST00000260682.6	+	5	767	c.755A>C	c.(754-756)cAa>cCa	p.Q252P		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	252					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AAAGAACACCAAGAATCAATG	0.328													5	56					0	0	1	0	0	C	96708977	A	C	96708977	3	2	48	1	0	0	0	0	1	0	0	0	4191	130	5	4	773	4	CYP2C9	10	96708977	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	354419	96708977	38825770	2456	6850										
TCTN3	26123	broad.mit.edu	37	chr10	97443223	97443223	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctaacataagtttgaaagCctttgcagcttttctcatta	6	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:97443223C>T	ENST00000371209.5	-	10	1258	c.1259G>A	c.(1258-1260)gGc>gAc	p.G420D	TCTN3_ENST00000265993.8_Intron|TCTN3_ENST00000371217.4_Intron|TCTN3_ENST00000430368.1_Intron			Q6NUS6	TECT3_HUMAN	tectonic family member 3	0					apoptosis	integral to membrane				breast(3)|endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		AGTTTGAAAGCCTTTGCAGCT	0.368													7	19					0	0	1	0	0	T	97443223	C	T	97443223	3	4	48	1	0	0	0	0	1	0	0	0	15782	754	26	3		3	TCTN3	10	97443223	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	734246	97443223	38091524	2457	6851										
CC2D2B	387707	broad.mit.edu	37	chr10	97772424	97772424	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttagtcacaagatatatcAaggcattaaatccacctcag	5	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:97772424A>G	ENST00000344386.3	+	4	420	c.256A>G	c.(256-258)Aag>Gag	p.K86E	ENTPD1-AS1_ENST00000454638.1_RNA|CC2D2B_ENST00000410012.2_Missense_Mutation_p.K86E|CC2D2B_ENST00000371198.2_Intron|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	86										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		AAGATATATCAAGGCATTAAA	0.299													14	34					0	0	1	0	0	G	97772424	A	G	97772424	3	3	48	1	0	0	0	0	1	0	0	0	2747	131	5	4	266	4	CC2D2B	10	97772424	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	329201	97772424	37762323	2458	6852										
CC2D2B	387707	broad.mit.edu	37	chr10	97772451	97772451	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaatccacctcagcaacttCtggatatatttcttcacaat	3	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:97772451C>T	ENST00000344386.3	+	4	447	c.283C>T	c.(283-285)Ctg>Ttg	p.L95L	ENTPD1-AS1_ENST00000454638.1_RNA|CC2D2B_ENST00000410012.2_Silent_p.L95L|CC2D2B_ENST00000371198.2_Intron|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	95										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TCAGCAACTTCTGGATATATT	0.318													10	27					0	0	1	0	0	T	97772451	C	T	97772451	2	4	48	1	0	0	0	0	0	0	0	1	2747	912	32	3		3	CC2D2B	10	97772451	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	27	97772451	37762296	2459	6853										
ZNF518A	9849	broad.mit.edu	37	chr10	97920080	97920080	+	RNA	SNP	C	C	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggcttttcccttttagttCtaaacagcttgtgaaatgtc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:97920080C>A	ENST00000534948.1	+	0	4858							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CCTTTTAGTTCTAAACAGCTT	0.393													24	34					1.9806e-07	2.28356e-07	1	1	0	A	97920080	C	A	97920080	1	1	48	0	1	0	0	0	0	0	0	0	18018	913	32	2		2	ZNF518A	10	97920080	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	147629	97920080	37614667	2460	6854	22	2								
ZNF518A	9849	broad.mit.edu	37	chr10	97920089	97920089	+	RNA	SNP	T	T	G													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccttttagttctaaacagcTtgtgaaatgtctaggagaaa							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:97920089T>G	ENST00000534948.1	+	0	4867							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TCTAAACAGCTTGTGAAATGT	0.378													17	40					0	0	1	0	0	G	97920089	T	G	97920089	1	3	48	0	1	0	0	0	0	0	0	0	18018	1609	56	4		4	ZNF518A	10	97920089	RNA	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	9	97920089	37614658	2461	6855	22	2								
TM9SF3	56889	broad.mit.edu	37	chr10	98336396	98336396	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaaggtttacttacctttaAatttaatatccagaccacta	3	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:98336396A>C	ENST00000371142.4	-	2	509	c.293T>G	c.(292-294)tTt>tGt	p.F98C		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	98						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		CTTACCTTTAAATTTAATATC	0.353													6	49					0	0	1	0	0	C	98336396	A	C	98336396	3	2	48	1	0	0	0	0	1	0	0	0	16038	14	1	4	1532	4	TM9SF3	10	98336396	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	416307	98336396	37198351	2462	6856										
SLIT1	6585	broad.mit.edu	37	chr10	98825776	98825776	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggcctgtactcacaaatTtttaaggtccgtagctcccc	7	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:98825776T>G	ENST00000266058.4	-	5	726	c.481A>C	c.(481-483)Aat>Cat	p.N161H	SLIT1_ENST00000371070.4_Missense_Mutation_p.N161H|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371041.3_Missense_Mutation_p.N161H	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	161					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		ACTCACAAATTTTTAAGGTCC	0.587													4	5					0	0	1	0	0	G	98825776	T	G	98825776	3	3	48	1	0	0	0	0	1	0	0	0	14792	1841	64	4	4255	4	SLIT1	10	98825776	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	489380	98825776	36708971	2463	6857										
ZFYVE27	118813	broad.mit.edu	37	chr10	99498292	99498292	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagccccagcgtgatgcccGaggctcccctggagtctcca	12	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:99498292G>A	ENST00000393677.4	+	2	262	c.58G>A	c.(58-60)Gag>Aag	p.E20K	ZFYVE27_ENST00000356257.4_Missense_Mutation_p.E20K|ZFYVE27_ENST00000337540.7_Missense_Mutation_p.E20K|ZFYVE27_ENST00000370613.3_Missense_Mutation_p.E20K|ZFYVE27_ENST00000370610.3_Intron|ZFYVE27_ENST00000357540.4_Missense_Mutation_p.E20K|ZFYVE27_ENST00000359980.3_Missense_Mutation_p.E20K|ZFYVE27_ENST00000453958.2_Missense_Mutation_p.E20K	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	20					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		CGTGATGCCCGAGGCTCCCCT	0.537													53	65					0	0	1	0	0	A	99498292	G	A	99498292	3	1	48	1	0	0	0	0	1	0	0	0	17726	1059	37	1	60	1	ZFYVE27	10	99498292	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	672516	99498292	36036455	2464	6858										
HPS1	3257	broad.mit.edu	37	chr10	100189343	100189343	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcacctgagctctgatcGccaggggaaggagctggtgt	14	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:100189343G>A	ENST00000325103.6	-	10	1157	c.924C>T	c.(922-924)ggC>ggT	p.G308G	HPS1_ENST00000361490.4_Silent_p.G308G|HPS1_ENST00000467246.1_5'UTR|HPS1_ENST00000338546.5_Silent_p.G308G	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	308					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		AGCTCTGATCGCCAGGGGAAG	0.587									Hermansky-Pudlak syndrome				12	34					0	0	1	0	0	A	100189343	G	A	100189343	2	1	48	1	0	0	0	0	0	0	0	1	7379	1074	38	1		1	HPS1	10	100189343	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	691051	100189343	35345404	2465	6859										
CNNM1	26507	broad.mit.edu	37	chr10	101124759	101124759	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggctggatcttctgtctttCgtatgtatctctcaaacccc	7	12	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101124759C>T	ENST00000356713.4	+	6	2465	c.2176_splice	c.e6+1	p.L726_splice	CNNM1_ENST00000446890.1_Splice_Site_p.L655_splice|CNNM1_ENST00000370528.3_Splice_Site_p.L655_splice|CNNM1_ENST00000370534.4_Splice_Site_p.L361_splice	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	726					ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		TTCTGTCTTTCGTATGTATCT	0.547													15	16					0	0	1	0	0	T	101124759	C	T	101124759	5	4	48	1	0	0	0	0	0	0	1	0	3635	898	31	1	2198	1	CNNM1	10	101124759	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	935416	101124759	34409988	2466	6860										
GOT1	2805	broad.mit.edu	37	chr10	101157417	101157417	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcaggtagatgtgcttttCattgaccagatactcaacct	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101157417C>A	ENST00000370508.5	-	9	1156	c.1129G>T	c.(1129-1131)Gaa>Taa	p.E377*	GOT1_ENST00000543866.1_Nonsense_Mutation_p.E356*	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	377					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATGTGCTTTTCATTGACCAGA	0.458													35	64					8.4185e-14	1.08646e-13	1	1	0	A	101157417	C	A	101157417	4	1	48	1	0	0	0	0	0	1	0	0	6617	835	29	2	116	2	GOT1	10	101157417	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32658	101157417	34377330	2467	6861										
ABCC2	1244	broad.mit.edu	37	chr10	101556891	101556891	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagcgtcctctgacactcGaggatgtctgggaagttgat	12	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101556891G>A	ENST00000370449.4	+	7	783	c.670G>A	c.(670-672)Gag>Aag	p.E224K	ABCC2_ENST00000370434.1_Missense_Mutation_p.E224K	NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	224						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCTGACACTCGAGGATGTCTG	0.517													18	37					0	0	1	0	0	A	101556891	G	A	101556891	3	1	48	1	0	0	0	0	1	0	0	0	53	1059	37	1	696	1	ABCC2	10	101556891	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	399474	101556891	33977856	2468	6862										
ABCC2	1244	broad.mit.edu	37	chr10	101605492	101605492	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgatggagtagatattgctTccattgggctccacgacctc	10	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101605492T>C	ENST00000370449.4	+	29	4212	c.4099T>C	c.(4099-4101)Tcc>Ccc	p.S1367P		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1367	ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGATATTGCTTCCATTGGGCT	0.527											OREG0020434	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	16					0	0	1	0	0	C	101605492	T	C	101605492	3	2	48	1	0	0	0	0	1	0	0	0	53	1783	62	4	4213	4	ABCC2	10	101605492	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	48601	101605492	33929255	2469	6863										
ABCC2	1244	broad.mit.edu	37	chr10	101606730	101606730	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttgcaggaccccatcctgTtctctggaagcctgaggatg	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101606730T>C	ENST00000370449.4	+	30	4272	c.4159T>C	c.(4159-4161)Ttc>Ctc	p.F1387L		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1387	ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCCCATCCTGTTCTCTGGAAG	0.537													48	362					0	0	1	0	0	C	101606730	T	C	101606730	3	2	48	1	0	0	0	0	1	0	0	0	53	1725	60	4	4277	4	ABCC2	10	101606730	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1238	101606730	33928017	2470	6864										
DNMBP	23268	broad.mit.edu	37	chr10	101637071	101637071	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttgggtttcgtgccttgAaggtgtagacagcaaaatag	12	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101637071A>G	ENST00000342239.3	-	17	4734	c.4643T>C	c.(4642-4644)tTc>tCc	p.F1548S	DNMBP_ENST00000540316.1_Missense_Mutation_p.F460S|DNMBP_ENST00000324109.4_Missense_Mutation_p.F1524S|DNMBP_ENST00000543621.1_Missense_Mutation_p.F770S			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1524	SH3 6.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TCGTGCCTTGAAGGTGTAGAC	0.483													36	63					0	0	1	0	0	G	101637071	A	G	101637071	3	3	48	1	0	0	0	0	1	0	0	0	4701	246	9	4	166	4	DNMBP	10	101637071	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	30341	101637071	33897676	2471	6865										
CPN1	1369	broad.mit.edu	37	chr10	101816907	101816907	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagataattaaagtcttgcaTtcctaagggaaagagggcag	12	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:101816907T>G	ENST00000370418.3	-	6	1125	c.874A>C	c.(874-876)Atg>Ctg	p.M292L		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	292	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		AAGTCTTGCATTCCTAAGGGA	0.458													61	125					0	0	1	0	0	G	101816907	T	G	101816907	3	3	48	1	0	0	0	0	1	0	0	0	3832	1493	52	4	518	4	CPN1	10	101816907	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	179836	101816907	33717840	2472	6866										
WNT8B	7479	broad.mit.edu	37	chr10	102242045	102242045	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcggtgaagggcaccatGaaacgcacgtgcaagtgcca	14	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:102242045G>T	ENST00000343737.5	+	6	656	c.528G>T	c.(526-528)atG>atT	p.M176I		NM_003393.3	NP_003384.2	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family, member 8B	176					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		AGGGCACCATGAAACGCACGT	0.637											OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	19					1.02788e-11	1.28326e-11	1	1	0	T	102242045	G	T	102242045	3	4	48	1	0	0	0	0	1	0	0	0	17456	1290	45	2	550	2	WNT8B	10	102242045	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	425138	102242045	33292702	2473	6867										
LZTS2	84445	broad.mit.edu	37	chr10	102766522	102766522	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttggatgctgaggcggccgGactccgggagccccctgtgc	17	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:102766522G>A	ENST00000370220.1	+	4	4670	c.1607G>A	c.(1606-1608)gGa>gAa	p.G536E	LZTS2_ENST00000370223.3_Missense_Mutation_p.G536E			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	536	Sufficient for interaction with CTNNB1.|Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GAGGCGGCCGGACTCCGGGAG	0.677													9	19					0	0	1	0	0	A	102766522	G	A	102766522	3	1	48	1	0	0	0	0	1	0	0	0	9184	1174	41	3	1621	3	LZTS2	10	102766522	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	524477	102766522	32768225	2474	6868										
PPRC1	23082	broad.mit.edu	37	chr10	103898913	103898913	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccccaccctctttcttagaGacctcttcccccaagcttcc	3	20	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:103898913G>T	ENST00000278070.2	+	5	687	c.648G>T	c.(646-648)gaG>gaT	p.E216D	PPRC1_ENST00000413464.2_Missense_Mutation_p.E216D	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CTTTCTTAGAGACCTCTTCCC	0.552													7	100					0.00307968	0.00320271	1	1	0	T	103898913	G	T	103898913	3	4	48	1	0	0	0	0	1	0	0	0	12458	933	33	2	666	2	PPRC1	10	103898913	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1132391	103898913	31635834	2475	6869										
PPRC1	23082	broad.mit.edu	37	chr10	103899139	103899139	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaagcaacagcagcagagAtggcagtgccagcagctggt	13	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:103899139A>C	ENST00000278070.2	+	5	913	c.874A>C	c.(874-876)Atg>Ctg	p.M292L	PPRC1_ENST00000413464.2_Missense_Mutation_p.M292L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGCAGCAGAGATGGCAGTGCC	0.587													9	98					0	0	1	0	0	C	103899139	A	C	103899139	3	2	48	1	0	0	0	0	1	0	0	0	12458	333	12	4	892	4	PPRC1	10	103899139	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	226	103899139	31635608	2476	6870										
GBF1	8729	broad.mit.edu	37	chr10	104130495	104130495	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgtgtgtggcagactgttCgagaccatctataccacctc	10	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:104130495C>T	ENST00000369983.3	+	29	3795	c.3535C>T	c.(3535-3537)Cga>Tga	p.R1179*		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1179					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GCAGACTGTTCGAGACCATCT	0.567													30	69					0	0	1	0	0	T	104130495	C	T	104130495	4	4	48	1	0	0	0	0	0	1	0	0	6310	876	31	1	3645	1	GBF1	10	104130495	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	231356	104130495	31404252	2477	6871										
CYP17A1	1586	broad.mit.edu	37	chr10	104592872	104592872	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgaaagcagctctgagtCttgatctgggccagcattgc	11	10	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:104592872C>A	ENST00000369887.3	-	5	1018	c.847G>T	c.(847-849)Gac>Tac	p.D283Y	CYP17A1-AS1_ENST00000369884.4_RNA	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	283					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	AGCTCTGAGTCTTGATCTGGG	0.512													27	55					1.33986e-20	1.83757e-20	1	1	0	A	104592872	C	A	104592872	3	1	48	1	0	0	0	0	1	0	0	0	4170	913	32	2	695	2	CYP17A1	10	104592872	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	462377	104592872	30941875	2478	6872										
INA	9118	broad.mit.edu	37	chr10	105037959	105037959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgagatcgagggcctgcgcGgggccaacgagtccttggag	17	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:105037959G>A	ENST00000369849.4	+	1	1040	c.991G>A	c.(991-993)Ggg>Agg	p.G331R		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	331	Coil 2.|Rod.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		GGGCCTGCGCGGGGCCAACGA	0.711													5	11					0	0	1	0	0	A	105037959	G	A	105037959	3	1	48	1	0	0	0	0	1	0	0	0	7773	1116	39	1	993	1	INA	10	105037959	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	445087	105037959	30496788	2479	6873										
TAF5	6877	broad.mit.edu	37	chr10	105147069	105147069	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactgtgcggctctgggacgTcctgaatggtaactgtgtaa	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:105147069T>C	ENST00000369839.3	+	9	1990	c.1967T>C	c.(1966-1968)gTc>gCc	p.V656A	TAF5_ENST00000351396.4_Missense_Mutation_p.V601A	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	656					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CTCTGGGACGTCCTGAATGGT	0.413													6	44					0	0	1	0	0	C	105147069	T	C	105147069	3	2	48	1	0	0	0	0	1	0	0	0	15584	1667	58	4	2001	4	TAF5	10	105147069	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	109110	105147069	30387678	2480	6874										
TAF5	6877	broad.mit.edu	37	chr10	105147784	105147784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaatggataatacagttcGattatgggatgctatcaaag	9	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:105147784G>A	ENST00000369839.3	+	11	2230	c.2207G>A	c.(2206-2208)cGa>cAa	p.R736Q	TAF5_ENST00000351396.4_Missense_Mutation_p.R681Q	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	736					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AATACAGTTCGATTATGGGAT	0.373													21	45					0	0	1	0	0	A	105147784	G	A	105147784	3	1	48	1	0	0	0	0	1	0	0	0	15584	1058	37	1	2249	1	TAF5	10	105147784	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	715	105147784	30386963	2481	6875										
PDCD11	22984	broad.mit.edu	37	chr10	105158249	105158249	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccacaaaccagagaaagcTttccagcagtcagttgaaca	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:105158249T>G	ENST00000369797.3	+	2	160	c.66T>G	c.(64-66)gcT>gcG	p.A22A		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	22					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CAGAGAAAGCTTTCCAGCAGT	0.403													30	57					0	0	1	0	0	G	105158249	T	G	105158249	2	3	48	1	0	0	0	0	0	0	0	1	11663	1596	56	4		4	PDCD11	10	105158249	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	10465	105158249	30376498	2482	6876										
OBFC1	79991	broad.mit.edu	37	chr10	105648830	105648830	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtacattataccacttacGatttggtttctggcagtcct	7	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:105648830G>A	ENST00000224950.3	-	9	1116	c.949_splice	c.e9+1	p.H317_splice	OBFC1_ENST00000466828.1_5'UTR|OBFC1_ENST00000369764.1_Splice_Site_p.H317_splice	NM_024928.4	NP_079204.2	Q9H668	STN1_HUMAN	oligonucleotide/oligosaccharide-binding fold containing 1	317					positive regulation of DNA replication|telomere maintenance via telomere lengthening		protein binding|single-stranded telomeric DNA binding	p.H317Y(2)		large_intestine(3)|lung(7)|ovary(1)|pancreas(2)	13		Colorectal(252;0.178)		Epithelial(162;3.39e-10)|all cancers(201;1.32e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0151)		TACCACTTACGATTTGGTTTC	0.498													18	32					0	0	1	0	0	A	105648830	G	A	105648830	5	1	48	1	0	0	0	0	0	0	1	0	10854	1072	37	1	165	1	OBFC1	10	105648830	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	490581	105648830	29885917	2483	6877										
CCDC147	159686	broad.mit.edu	37	chr10	106209891	106209891	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaatataaatatgaggtagaGaaacttaccaatgagctcca	8	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:106209891G>T	ENST00000369704.3	+	17	2573	c.2439G>T	c.(2437-2439)gaG>gaT	p.E813D		NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	813										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATGAGGTAGAGAAACTTACCA	0.318													24	48					1.85244e-09	2.22951e-09	1	1	0	T	106209891	G	T	106209891	3	4	48	1	0	0	0	0	1	0	0	0	2799	933	33	2	2505	2	CCDC147	10	106209891	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	561061	106209891	29324856	2484	6878										
SMC3	9126	broad.mit.edu	37	chr10	112361580	112361580	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagtgtatgaagaaaattCgagaacttggatcacttccc	9	7	1	4	rs139627416		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:112361580C>T	ENST00000361804.4	+	24	2956	c.2830C>T	c.(2830-2832)Cga>Tga	p.R944*		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	944					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity	p.R944*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GAAGAAAATTCGAGAACTTGG	0.368													24	57					0	0	1	0	0	T	112361580	C	T	112361580	4	4	48	1	0	0	0	0	0	1	0	0	14837	876	31	1	2924	1	SMC3	10	112361580	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6151689	112361580	23173167	2485	6879										
ACSL5	51703	broad.mit.edu	37	chr10	114169443	114169443	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatccctatatgatgctgaGgtatggatctgaaatttagc	9	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:114169443G>A	ENST00000393081.1	+	7	1018	c.711_splice	c.e7+1	p.E237_splice	ACSL5_ENST00000354273.4_Splice_Site_p.E237_splice|ACSL5_ENST00000433418.1_Splice_Site_p.E237_splice|ACSL5_ENST00000354655.4_Splice_Site_p.E237_splice|ACSL5_ENST00000369410.3_5'UTR|ACSL5_ENST00000356116.1_Splice_Site_p.E293_splice	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	237					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		ATGATGCTGAGGTATGGATCT	0.468													30	85					0	0	1	0	0	A	114169443	G	A	114169443	5	1	48	1	0	0	0	0	0	0	1	0	180	1014	35	3	905	3	ACSL5	10	114169443	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1807863	114169443	21365304	2486	6880										
TCF7L2	6934	broad.mit.edu	37	chr10	114912121	114912121	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtccagagaagagcaagcGaaatactacgagctggcccg	12	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:114912121G>A	ENST00000355995.4	+	11	1698	c.1191G>A	c.(1189-1191)gcG>gcA	p.A397A	TCF7L2_ENST00000542695.1_Silent_p.A113A|TCF7L2_ENST00000543371.1_Silent_p.A397A|TCF7L2_ENST00000536810.1_Silent_p.A397A|TCF7L2_ENST00000538897.1_Silent_p.A397A|TCF7L2_ENST00000369397.4_Silent_p.A374A|TCF7L2_ENST00000355717.4_Silent_p.A421A|TCF7L2_ENST00000369386.1_Silent_p.A40A|TCF7L2_ENST00000352065.5_Silent_p.A374A|TCF7L2_ENST00000369389.1_Silent_p.A108A|TCF7L2_ENST00000545257.1_Silent_p.A397A|TCF7L2_ENST00000534894.1_Silent_p.A397A|TCF7L2_ENST00000466338.1_3'UTR			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	397					anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.A397A(1)|p.A374A(1)	VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		AAGAGCAAGCGAAATACTACG	0.502			T	VTI1A	colorectal								101	237					0	0	1	0	0	A	114912121	G	A	114912121	2	1	48	1	0	0	0	0	0	0	0	1	15757	1045	37	1		1	TCF7L2	10	114912121	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	742678	114912121	20622626	2487	6881										
HABP2	3026	broad.mit.edu	37	chr10	115335708	115335708	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggactgcctcgtccatggGagcaccttcacatgcagctg	13	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:115335708G>A	ENST00000537906.1	+	5	404	c.242G>A	c.(241-243)gGa>gAa	p.G81E	HABP2_ENST00000351270.3_Silent_p.G92G|HABP2_ENST00000541666.1_Silent_p.G92G|HABP2_ENST00000542051.1_Silent_p.G66G			Q14520	HABP2_HUMAN	hyaluronan binding protein 2	0	EGF-like 1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TCGTCCATGGGAGCACCTTCA	0.527													58	117					0	0	1	0	0	A	115335708	G	A	115335708	3	1	48	1	0	0	0	0	1	0	0	0	6978	1161	41	3	290	3	HABP2	10	115335708	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	423587	115335708	20199039	2488	6882										
HABP2	3026	broad.mit.edu	37	chr10	115337894	115337894	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccagttcaaggggaaattCtgtgaaataggtatgggtct	13	5	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:115337894C>A	ENST00000351270.3	+	6	654	c.558C>A	c.(556-558)ttC>ttA	p.F186L	HABP2_ENST00000537906.1_Missense_Mutation_p.S175Y|HABP2_ENST00000541666.1_Missense_Mutation_p.F186L|HABP2_ENST00000542051.1_Missense_Mutation_p.F160L	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	186	EGF-like 3.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		AGGGGAAATTCTGTGAAATAG	0.537													33	34					3.62531e-18	4.89791e-18	1	1	0	A	115337894	C	A	115337894	3	1	48	1	0	0	0	0	1	0	0	0	6978	912	32	2	580	2	HABP2	10	115337894	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2186	115337894	20196853	2489	6883										
NRAP	4892	broad.mit.edu	37	chr10	115389405	115389405	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcatatcttcaggcagcAcagtgtattcatgcagtttc	7	10	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:115389405A>G	ENST00000369358.4	-	19	2250	c.2006T>C	c.(2005-2007)gTg>gCg	p.V669A	NRAP_ENST00000360478.3_Missense_Mutation_p.V626A|NRAP_ENST00000369360.3_Missense_Mutation_p.V634A|NRAP_ENST00000359988.3_Missense_Mutation_p.V661A			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	661						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TTCAGGCAGCACAGTGTATTC	0.498													27	53					0	0	1	0	0	G	115389405	A	G	115389405	3	3	48	1	0	0	0	0	1	0	0	0	10685	159	6	4	3306	4	NRAP	10	115389405	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	51511	115389405	20145342	2490	6884										
NRAP	4892	broad.mit.edu	37	chr10	115413816	115413816	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgagcctcaaccatccttacAatttcggggtctggcagagc	10	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:115413816A>G	ENST00000369358.4	-	5	673	c.429T>C	c.(427-429)atT>atC	p.I143I	NRAP_ENST00000360478.3_Silent_p.I143I|NRAP_ENST00000369360.3_Silent_p.I143I|NRAP_ENST00000359988.3_Silent_p.I143I			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	143						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CCATCCTTACAATTTCGGGGT	0.453													79	139					0	0	1	0	0	G	115413816	A	G	115413816	2	3	48	1	0	0	0	0	0	0	0	1	10685	126	5	4		4	NRAP	10	115413816	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	24411	115413816	20120931	2491	6885										
CASP7	840	broad.mit.edu	37	chr10	115489079	115489079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgttgaaggctattactCgtggaggagcccaggaagag	14	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:115489079C>T	ENST00000369321.2	+	8	1111	c.791C>T	c.(790-792)tCg>tTg	p.S264L	CASP7_ENST00000369331.4_Missense_Mutation_p.R220C|CASP7_ENST00000452490.2_Missense_Mutation_p.S206L|CASP7_ENST00000369315.1_Missense_Mutation_p.S231L|CASP7_ENST00000345633.4_Missense_Mutation_p.S231L|CASP7_ENST00000369318.3_Missense_Mutation_p.S231L	NM_033338.5	NP_203124.1	P55210	CASP7_HUMAN	caspase 7, apoptosis-related cysteine peptidase	231					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		GGCTATTACTCGTGGAGGAGC	0.507													26	56					0	0	1	0	0	T	115489079	C	T	115489079	3	4	48	1	0	0	0	0	1	0	0	0	2694	893	31	1	895	1	CASP7	10	115489079	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	75263	115489079	20045668	2492	6886										
FAM160B1	57700	broad.mit.edu	37	chr10	116593063	116593063	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttagatatactggttcaaGaagaaaatgaacgggaatct	10	4	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:116593063G>T	ENST00000369248.4	+	3	531	c.196G>T	c.(196-198)Gaa>Taa	p.E66*	FAM160B1_ENST00000369250.3_Nonsense_Mutation_p.E66*|FAM160B1_ENST00000369246.1_Nonsense_Mutation_p.E66*	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	66										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						ACTGGTTCAAGAAGAAAATGA	0.368													7	79					0.0293803	0.0299069	1	1	0	T	116593063	G	T	116593063	4	4	48	1	0	0	0	0	0	1	0	0	5500	943	33	2	206	2	FAM160B1	10	116593063	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1103984	116593063	18941684	2493	6887										
GFRA1	2674	broad.mit.edu	37	chr10	117849401	117849401	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggctgccacacggtcacatCggagccattgccaaaggctt	11	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:117849401C>T	ENST00000439649.3	-	8	1400	c.1033G>A	c.(1033-1035)Gat>Aat	p.D345N	GFRA1_ENST00000369236.1_Missense_Mutation_p.D345N|GFRA1_ENST00000355422.6_Missense_Mutation_p.D350N|GFRA1_ENST00000544592.1_Missense_Mutation_p.D229N	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	350					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		ACGGTCACATCGGAGCCATTG	0.522													7	22					0	0	1	0	0	T	117849401	C	T	117849401	3	4	48	1	0	0	0	0	1	0	0	0	6388	884	31	1	361	1	GFRA1	10	117849401	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1256338	117849401	17685346	2494	6888										
PNLIP	5406	broad.mit.edu	37	chr10	118307936	118307936	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacaaatagaaaaactcgctTtattattcatggattcatag	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:118307936T>G	ENST00000369221.2	+	4	294	c.266T>G	c.(265-267)tTt>tGt	p.F89C	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	89					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AAAACTCGCTTTATTATTCAT	0.403													12	66					0	0	1	0	0	G	118307936	T	G	118307936	3	3	48	1	0	0	0	0	1	0	0	0	12196	1841	64	4	276	4	PNLIP	10	118307936	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	458535	118307936	17226811	2495	6889										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118355761	118355761	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccccttccaaagttcacctCattggccacagcctgggagc	8	17	2	0	rs35466965		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:118355761C>A	ENST00000528052.1	+	6	572	c.501C>A	c.(499-501)ctC>ctA	p.L167L	PNLIPRP1_ENST00000534537.1_Silent_p.L167L|PNLIPRP1_ENST00000358834.4_Silent_p.L167L			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	167					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		AAGTTCACCTCATTGGCCACA	0.532													68	141					7.97268e-31	1.13956e-30	1	1	0	A	118355761	C	A	118355761	2	1	48	1	0	0	0	0	0	0	0	1	12197	813	29	2		2	PNLIPRP1	10	118355761	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47825	118355761	17178986	2496	6890										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118359564	118359564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttgttttcccaggaaccCgggactttgtggcttgcaat	10	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:118359564C>T	ENST00000528052.1	+	9	891	c.820C>T	c.(820-822)Cgg>Tgg	p.R274W	PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.R274W|PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.R274W			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	274					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CCCAGGAACCCGGGACTTTGT	0.488													26	71					0	0	1	0	0	T	118359564	C	T	118359564	3	4	48	1	0	0	0	0	1	0	0	0	12197	643	23	1	850	1	PNLIPRP1	10	118359564	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3803	118359564	17175183	2497	6891										
HSPA12A	259217	broad.mit.edu	37	chr10	118434331	118434331	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcccaactttgacactcttCgaagtggctatatcaatggc	7	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:118434331C>T	ENST00000369209.3	-	12	2093	c.1989G>A	c.(1987-1989)tcG>tcA	p.S663S		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	663							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		TGACACTCTTCGAAGTGGCTA	0.557													16	31					0	0	1	0	0	T	118434331	C	T	118434331	2	4	48	1	0	0	0	0	0	0	0	1	7446	871	31	1		1	HSPA12A	10	118434331	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	74767	118434331	17100416	2498	6892										
RAB11FIP2	22841	broad.mit.edu	37	chr10	119798541	119798541	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaaatggattggttgactCataatcaaaatagtcctggc	9	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:119798541C>A	ENST00000355624.3	-	3	1646	c.1207G>T	c.(1207-1209)Gag>Tag	p.E403*	RAB11FIP2_ENST00000369199.3_Nonsense_Mutation_p.E403*|RP11-354M20.3_ENST00000451610.2_RNA	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	403					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		TTGGTTGACTCATAATCAAAA	0.368													22	42					3.8784e-16	5.13982e-16	1	1	0	A	119798541	C	A	119798541	4	1	48	1	0	0	0	0	0	1	0	0	12945	835	29	2	343	2	RAB11FIP2	10	119798541	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1364210	119798541	15736206	2499	6893										
EIF3A	8661	broad.mit.edu	37	chr10	120816463	120816463	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaccttcttttcttgattCtttaggcgttcttgaagttc	6	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:120816463C>T	ENST00000369144.3	-	13	2194	c.2067G>A	c.(2065-2067)aaG>aaA	p.K689K	EIF3A_ENST00000478852.1_Intron|EIF3A_ENST00000541549.1_Silent_p.K655K	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	689	Glu-rich.|Interaction with EIF3B.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTTCTTGATTCTTTAGGCGTT	0.348													11	22					0	0	1	0	0	T	120816463	C	T	120816463	2	4	48	1	0	0	0	0	0	0	0	1	5038	912	32	3		3	EIF3A	10	120816463	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1017922	120816463	14718284	2500	6894										
FAM45A	404636	broad.mit.edu	37	chr10	120877030	120877030	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttgttgtcctttcttacaGaatgtacctgaaacatggga	8	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:120877030G>A	ENST00000361432.2	+	4	358		c.e4-1		FAM45A_ENST00000544016.1_Intron|FAM45A_ENST00000489988.1_Splice_Site|FAM45A_ENST00000535029.1_Splice_Site	NM_207009.2	NP_996892.1	Q8TCE6	FA45A_HUMAN	family with sequence similarity 45, member A											breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	14		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		CTTTCTTACAGAATGTACCTG	0.443													42	71					0	0	1	0	0	A	120877030	G	A	120877030	5	1	48	1	0	0	0	0	0	0	1	0	5599	956	33	3	346	3	FAM45A	10	120877030	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	60567	120877030	14657717	2501	6895										
SFXN4	119559	broad.mit.edu	37	chr10	120907363	120907363	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattctggatgctagcgtttCtctaacagcctagcaaaaat	7	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:120907363C>A	ENST00000355697.2	-	12	761	c.742G>T	c.(742-744)Gaa>Taa	p.E248*	SFXN4_ENST00000461438.1_5'UTR|SFXN4_ENST00000330036.6_Nonsense_Mutation_p.E239*	NM_213649.1	NP_998814.1	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	248					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	11		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		GCTAGCGTTTCTCTAACAGCC	0.488													38	45					3.62531e-18	4.89791e-18	1	1	0	A	120907363	C	A	120907363	4	1	48	1	0	0	0	0	0	1	0	0	14250	922	32	2	283	2	SFXN4	10	120907363	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30333	120907363	14627384	2502	6896										
DMBT1	1755	broad.mit.edu	37	chr10	124345687	124345687	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgtgtgatgacagctgggAcaccaatgatgccaatgtgg	14	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:124345687A>C	ENST00000338354.3	+	16	1677	c.1571A>C	c.(1570-1572)gAc>gCc	p.D524A	DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368909.3_Missense_Mutation_p.D524A|DMBT1_ENST00000344338.3_Missense_Mutation_p.D514A|DMBT1_ENST00000368955.3_Missense_Mutation_p.D514A|DMBT1_ENST00000330163.4_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	524	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GACAGCTGGGACACCAATGAT	0.612													156	558					0	0	1	0	0	C	124345687	A	C	124345687	3	2	48	1	0	0	0	0	1	0	0	0	4605	275	10	4	1633	4	DMBT1	10	124345687	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3438324	124345687	11189060	2503	6897										
DMBT1	1755	broad.mit.edu	37	chr10	124390744	124390744	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggcagtgccggaaccgagGctggttctcccacaactgta	12	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:124390744G>A	ENST00000338354.3	+	46	6012	c.5906G>A	c.(5905-5907)gGc>gAc	p.G1969D	DMBT1_ENST00000368956.2_Missense_Mutation_p.G1341D|DMBT1_ENST00000359586.6_Missense_Mutation_p.G689D|DMBT1_ENST00000368909.3_Missense_Mutation_p.G1969D|DMBT1_ENST00000344338.3_Missense_Mutation_p.G1959D|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1959D|DMBT1_ENST00000330163.4_Missense_Mutation_p.G1341D			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1969	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CGGAACCGAGGCTGGTTCTCC	0.532													52	97					0	0	1	0	0	A	124390744	G	A	124390744	3	1	48	1	0	0	0	0	1	0	0	0	4605	1203	42	3	6088	3	DMBT1	10	124390744	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	45057	124390744	11144003	2504	6898										
CUZD1	50624	broad.mit.edu	37	chr10	124594383	124594383	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatggtgattcaagtatagtCttttcaaatgaattggattc	8	4	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:124594383C>A	ENST00000368904.1	-	9	2170	c.1221G>T	c.(1219-1221)aaG>aaT	p.K407N	CUZD1_ENST00000545804.1_Missense_Mutation_p.K407N|CUZD1_ENST00000392790.1_Missense_Mutation_p.K407N			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	407	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CAAGTATAGTCTTTTCAAATG	0.333													8	25					1.06961e-07	1.24214e-07	1	1	0	A	124594383	C	A	124594383	3	1	48	1	0	0	0	0	1	0	0	0	4089	912	32	2	614	2	CUZD1	10	124594383	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	203639	124594383	10940364	2505	6899										
CTBP2	1488	broad.mit.edu	37	chr10	126678217	126678217	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccagggatgatcccttccAtggctgcaggaagtcctcct	10	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:126678217A>G	ENST00000309035.6	-	9	2958	c.2828T>C	c.(2827-2829)aTg>aCg	p.M943T	CTBP2_ENST00000411419.2_Missense_Mutation_p.M403T|CTBP2_ENST00000531469.1_Missense_Mutation_p.M403T|CTBP2_ENST00000337195.5_Missense_Mutation_p.M403T|CTBP2_ENST00000494626.2_Missense_Mutation_p.M403T|CTBP2_ENST00000334808.6_Missense_Mutation_p.M471T	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	403					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GATCCCTTCCATGGCTGCAGG	0.577													10	44					0	0	1	0	0	G	126678217	A	G	126678217	3	3	48	1	0	0	0	0	1	0	0	0	4022	217	8	4	133	4	CTBP2	10	126678217	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2083834	126678217	8856530	2506	6900										
CTBP2	1488	broad.mit.edu	37	chr10	126682453	126682453	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgactcatgcacgtcgagGgctgcccctcgtatcctgcc	10	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:126682453G>A	ENST00000309035.6	-	6	2632	c.2502C>T	c.(2500-2502)gcC>gcT	p.A834A	CTBP2_ENST00000411419.2_Silent_p.A294A|CTBP2_ENST00000531469.1_Silent_p.A294A|CTBP2_ENST00000337195.5_Silent_p.A294A|CTBP2_ENST00000494626.2_Silent_p.A294A|CTBP2_ENST00000334808.6_Silent_p.A362A	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	294					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GCACGTCGAGGGCTGCCCCTC	0.637													47	119					0	0	1	0	0	A	126682453	G	A	126682453	2	1	48	1	0	0	0	0	0	0	0	1	4022	1219	43	3		3	CTBP2	10	126682453	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4236	126682453	8852294	2507	6901										
C10orf137	26098	broad.mit.edu	37	chr10	127418874	127418874	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagggataacaacaaaccaaTtaatgtgctaactggaattg	8	6	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:127418874T>G	ENST00000337623.3	+	8	1037	c.932T>G	c.(931-933)aTt>aGt	p.I311S	C10orf137_ENST00000356792.4_Missense_Mutation_p.I345S	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AACAAACCAATTAATGTGCTA	0.308													15	53					0	0	1	0	0	G	127418874	T	G	127418874	3	3	48	1	0	0	0	0	1	0	0	0	1598	1493	52	4	962	4	C10orf137	10	127418874	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	736421	127418874	8115873	2508	6902										
BCCIP	56647	broad.mit.edu	37	chr10	127519170	127519170	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagcaatgatgatatggatGaagatgaggtttttggtttc	12	3	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:127519170G>T	ENST00000299130.3	+	4	373	c.361G>T	c.(361-363)Gaa>Taa	p.E121*	BCCIP_ENST00000478798.1_3'UTR|BCCIP_ENST00000368759.5_Nonsense_Mutation_p.E121*|BCCIP_ENST00000429863.2_Intron|BCCIP_ENST00000278100.6_Nonsense_Mutation_p.E121*	NM_078469.2	NP_510869.1	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A interacting protein	121	Interaction with BRCA2.				cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)	8		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGATATGGATGAAGATGAGGT	0.303													4	96					1	1	1	1	0	T	127519170	G	T	127519170	4	4	48	1	0	0	0	0	0	1	0	0	1354	1291	45	2	375	2	BCCIP	10	127519170	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	100296	127519170	8015577	2509	6903										
FANK1	92565	broad.mit.edu	37	chr10	127668792	127668792	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtgactcatcacagcattGaattatactgggatctggaa	9	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:127668792G>T	ENST00000368695.1	+	2	180	c.58G>T	c.(58-60)Gaa>Taa	p.E20*	FANK1_ENST00000449042.2_Nonsense_Mutation_p.E20*|FANK1_ENST00000368689.1_Nonsense_Mutation_p.E20*|FANK1_ENST00000368693.1_Nonsense_Mutation_p.E26*	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	26	Fibronectin type-III.					cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				TCACAGCATTGAATTATACTG	0.453													19	41					3.99206e-14	5.17458e-14	1	1	0	T	127668792	G	T	127668792	4	4	48	1	0	0	0	0	0	1	0	0	5704	1291	45	2	82	2	FANK1	10	127668792	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	149622	127668792	7865955	2510	6904										
C10orf90	118611	broad.mit.edu	37	chr10	128193194	128193194	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaactctgtgcaggcaaaaGatctctgatgccgacctgga	11	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:128193194G>T	ENST00000284694.7	-	3	695	c.575C>A	c.(574-576)tCt>tAt	p.S192Y	C10orf90_ENST00000544758.1_Missense_Mutation_p.S289Y|C10orf90_ENST00000454341.1_Missense_Mutation_p.S192Y|C10orf90_ENST00000392694.1_Missense_Mutation_p.S145Y|C10orf90_ENST00000356858.3_Missense_Mutation_p.S145Y|C10orf90_ENST00000368674.1_5'UTR	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	192										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		GCAGGCAAAAGATCTCTGATG	0.622											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	76					1.04121e-07	1.21041e-07	1	1	0	T	128193194	G	T	128193194	3	4	48	1	0	0	0	0	1	0	0	0	1627	942	33	2	1552	2	C10orf90	10	128193194	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	524402	128193194	7341553	2511	6905										
DOCK1	1793	broad.mit.edu	37	chr10	128795081	128795081	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatccagaattaactagcacGattagtctcttcagagctca	7	10	3	2	rs79043452	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:128795081G>A	ENST00000280333.6	+	7	652	c.543G>A	c.(541-543)acG>acA	p.T181T		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	181					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TAACTAGCACGATTAGTCTCT	0.368													13	115					0	0	1	0	0	A	128795081	G	A	128795081	2	1	48	1	0	0	0	0	0	0	0	1	4711	1045	37	1		1	DOCK1	10	128795081	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	601887	128795081	6739666	2512	6906										
DOCK1	1793	broad.mit.edu	37	chr10	128821490	128821490	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgaaatgatatctatgtaAcattagttcaaggagatttt	7	4	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:128821490A>C	ENST00000280333.6	+	14	1400	c.1291A>C	c.(1291-1293)Aca>Cca	p.T431P	RP11-223P11.3_ENST00000595456.1_RNA|RP11-223P11.2_ENST00000420941.2_RNA|RP11-223P11.3_ENST00000594614.1_RNA|RP11-223P11.3_ENST00000599979.1_RNA|RP11-223P11.3_ENST00000601826.1_RNA|RP11-223P11.3_ENST00000601242.1_RNA|RP11-223P11.3_ENST00000594559.1_RNA	NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	431	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TATCTATGTAACATTAGTTCA	0.378													57	82					0	0	1	0	0	C	128821490	A	C	128821490	3	2	48	1	0	0	0	0	1	0	0	0	4711	43	2	4	1345	4	DOCK1	10	128821490	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	26409	128821490	6713257	2513	6907										
MKI67	4288	broad.mit.edu	37	chr10	129901190	129901190	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggtgcttaccacgtctcCcacgggttctactttagggg	11	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:129901190C>T	ENST00000368654.3	-	13	9289	c.8914G>A	c.(8914-8916)Gga>Aga	p.G2972R	MKI67_ENST00000368653.3_Missense_Mutation_p.G2612R	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2972					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ACCACGTCTCCCACGGGTTCT	0.498													35	85					0	0	1	0	0	T	129901190	C	T	129901190	3	4	48	1	0	0	0	0	1	0	0	0	9645	632	22	3	868	3	MKI67	10	129901190	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1079700	129901190	5633557	2514	6908										
MKI67	4288	broad.mit.edu	37	chr10	129906274	129906274	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaagagttctccctctacaTctgctttcctgatacttctc	4	14	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:129906274T>C	ENST00000368654.3	-	13	4205	c.3830A>G	c.(3829-3831)gAt>gGt	p.D1277G	MKI67_ENST00000368653.3_Missense_Mutation_p.D917G	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1277	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCCTCTACATCTGCTTTCCT	0.488													61	139					0	0	1	0	0	C	129906274	T	C	129906274	3	2	48	1	0	0	0	0	1	0	0	0	9645	1435	50	4	5952	4	MKI67	10	129906274	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5084	129906274	5628473	2515	6909										
BNIP3	664	broad.mit.edu	37	chr10	133784368	133784368	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacactgagaacacactcacTtggggggaatattttccggc	11	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:133784368T>G	ENST00000540159.1	-	4	505	c.389_splice	c.e4+1	p.K130_splice	BNIP3_ENST00000368636.4_Splice_Site_p.K130_splice			Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 3	130					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACACACTCACTTGGGGGGAAT	0.473													4	61					0	0	1	0	0	G	133784368	T	G	133784368	5	3	48	1	0	0	0	0	0	0	1	0	1477	1623	56	4	207	4	BNIP3	10	133784368	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3878094	133784368	1750379	2516	6910										
INPP5A	3632	broad.mit.edu	37	chr10	134563304	134563304	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagttagaaaagaaactcttCgactacttcaaccaggaggt	8	9	2	2	rs149439109		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:134563304C>T	ENST00000368594.3	+	11	1135	c.858C>T	c.(856-858)ttC>ttT	p.F286F	INPP5A_ENST00000368593.3_Silent_p.F286F	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	286					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		AGAAACTCTTCGACTACTTCA	0.582													5	153					0	0	1	0	0	T	134563304	C	T	134563304	2	4	48	1	0	0	0	0	0	0	0	1	7797	883	31	1		1	INPP5A	10	134563304	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	778936	134563304	971443	2517	6911										
VENTX	27287	broad.mit.edu	37	chr10	135053551	135053551	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagctttctactcaacgtCttctggccttgccaatggcc	7	16	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:135053551C>A	ENST00000325980.9	+	3	1029	c.518C>A	c.(517-519)tCt>tAt	p.S173Y		NM_014468.2	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	173					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		TACTCAACGTCTTCTGGCCTT	0.637													24	48					2.21704e-12	2.79328e-12	1	1	0	A	135053551	C	A	135053551	3	1	48	1	0	0	0	0	1	0	0	0	17212	913	32	2	528	2	VENTX	10	135053551	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	490247	135053551	481196	2518	6912										
ZNF511	118472	broad.mit.edu	37	chr10	135125331	135125331	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaccggcaggtgagaggcgGatctacagacataggtcagt	15	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr10:135125331G>A	ENST00000359035.3	+	5	669	c.666G>A	c.(664-666)cgG>cgA	p.R222R	ZNF511_ENST00000361518.5_Silent_p.R222R|ZNF511_ENST00000463816.2_3'UTR|ZNF511_ENST00000368554.4_Silent_p.R157R			Q8NB15	ZN511_HUMAN	zinc finger protein 511	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	8		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		GTGAGAGGCGGATCTACAGAC	0.597													32	84					0	0	1	0	0	A	135125331	G	A	135125331	2	1	48	1	0	0	0	0	0	0	0	1	18011	1161	41	3		3	ZNF511	10	135125331	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	71780	135125331	409416	2519	6913										
RIC8A	60626	broad.mit.edu	37	chr11	209947	209947	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagcgggccatggagatcCtcaaagtgctcttcaacatc	10	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:209947C>A	ENST00000526104.1	+	3	2017	c.673C>A	c.(673-675)Ctc>Atc	p.L225I	RIC8A_ENST00000325207.5_Missense_Mutation_p.L225I|RIC8A_ENST00000527696.1_Missense_Mutation_p.L219I			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	225						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CATGGAGATCCTCAAAGTGCT	0.582													6	55					2.7689e-08	3.25926e-08	1	1	0	A	209947	C	A	209947	3	1	48	1	0	0	0	0	1	0	0	0	13404	681	24	5	683	5	RIC8A	11	209947	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		209947	134796569	2520	6914										
DEAF1	10522	broad.mit.edu	37	chr11	691572	691572	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgtctgcagcagcccccaCgttggccactgtcactgtgg	11	14	2	0	rs143376874		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:691572C>T	ENST00000382409.3	-	2	800	c.316G>A	c.(316-318)Gtg>Atg	p.V106M	DEAF1_ENST00000338675.6_Missense_Mutation_p.V106M	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	106	Ala-rich.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GCAGCCCCCACGTTGGCCACT	0.567													12	25					0	0	1	0	0	T	691572	C	T	691572	3	4	48	1	0	0	0	0	1	0	0	0	4403	536	19	1	1425	1	DEAF1	11	691572	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	481625	691572	134314944	2521	6915										
MUC6	4588	broad.mit.edu	37	chr11	1016454	1016454	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaaacaggagtggttgcaGaactcaagtgggggagttgt	17	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1016454G>T	ENST00000421673.2	-	31	6397	c.6347C>A	c.(6346-6348)tCt>tAt	p.S2116Y		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	2116	Ser-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTGGTTGCAGAACTCAAGTG	0.522													27	40					4.72057e-08	5.51616e-08	1	1	0	T	1016454	G	T	1016454	3	4	48	1	0	0	0	0	1	0	0	0	10027	942	33	2	984	2	MUC6	11	1016454	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	324882	1016454	133990062	2522	6916										
MUC2	4583	broad.mit.edu	37	chr11	1088722	1088722	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctacccccggtgccccaaGgacaggcccatctatgagga	11	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1088722G>T	ENST00000441003.2	+	26	3534	c.3507G>T	c.(3505-3507)aaG>aaT	p.K1169N	MUC2_ENST00000359061.5_Missense_Mutation_p.K1169N	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1169						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGTGCCCCAAGGACAGGCCCA	0.622													5	7					0.000602214	0.000636035	1	1	0	T	1088722	G	T	1088722	3	4	48	1	0	0	0	0	1	0	0	0	10022	991	35	5	3609	5	MUC2	11	1088722	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	72268	1088722	133917794	2523	6917										
MUC2	4583	broad.mit.edu	37	chr11	1095311	1095311	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccctccaagccgacgcccgGcaccaagccccccgagtgcc	10	22	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1095311G>A	ENST00000441003.2	+	32	6158	c.6131G>A	c.(6130-6132)gGc>gAc	p.G2044D	MUC2_ENST00000361558.6_Missense_Mutation_p.G182D|MUC2_ENST00000333592.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	2076						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGACGCCCGGCACCAAGCCC	0.672													16	30					0	0	1	0	0	A	1095311	G	A	1095311	3	1	48	1	0	0	0	0	1	0	0	0	10022	1203	42	3	6249	3	MUC2	11	1095311	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6589	1095311	133911205	2524	6918										
MUC5B	727897	broad.mit.edu	37	chr11	1276394	1276394	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaggatggctgctgggcccCgactggcacaccccccactg	12	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1276394C>T	ENST00000447027.1	+	36	15855	c.15797C>T	c.(15796-15798)cCg>cTg	p.P5266L	MUC5B_ENST00000529681.1_Missense_Mutation_p.P5263L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	5263	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGCTGGGCCCCGACTGGCACA	0.672													6	12					0	0	1	0	0	T	1276394	C	T	1276394	3	4	48	1	0	0	0	0	1	0	0	0	10026	652	23	1	15939	1	MUC5B	11	1276394	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	181083	1276394	133730122	2525	6919										
MUC5B	727897	broad.mit.edu	37	chr11	1279584	1279584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagctgtgttcgtacaatgGcaccttctacggggtaaggg	13	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1279584G>A	ENST00000447027.1	+	43	16647	c.16589G>A	c.(16588-16590)gGc>gAc	p.G5530D	MUC5B_ENST00000529681.1_Missense_Mutation_p.G5527D			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	5527	VWFC 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCGTACAATGGCACCTTCTAC	0.627													5	16					0	0	1	0	0	A	1279584	G	A	1279584	3	1	48	1	0	0	0	0	1	0	0	0	10026	1203	42	3	16759	3	MUC5B	11	1279584	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3190	1279584	133726932	2526	6920										
BRSK2	9024	broad.mit.edu	37	chr11	1459617	1459617	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgtttatgaaaacaaaaaaTatttgtaggtattgctgggt	9	3	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1459617T>G	ENST00000308219.9	+	3	654	c.268T>G	c.(268-270)Tat>Gat	p.Y90D	BRSK2_ENST00000526678.1_Missense_Mutation_p.Y90D|BRSK2_ENST00000531197.1_Missense_Mutation_p.Y90D|BRSK2_ENST00000382179.1_Missense_Mutation_p.Y136D|BRSK2_ENST00000528710.1_Missense_Mutation_p.Y30D|BRSK2_ENST00000528841.1_Missense_Mutation_p.Y90D|BRSK2_ENST00000308230.5_Missense_Mutation_p.Y90D	NM_001256627.1|NM_003957.3	NP_001243556.1|NP_003948.2	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	90	Protein kinase.				establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(1)|lung(5)	10		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		AAACAAAAAATATTTGTAGGT	0.582													39	79					0	0	1	0	0	G	1459617	T	G	1459617	3	3	48	1	0	0	0	0	1	0	0	0	1526	1406	49	4	278	4	BRSK2	11	1459617	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	180033	1459617	133546899	2527	6921										
CTSD	1509	broad.mit.edu	37	chr11	1778571	1778571	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacctgctcaggtagaaggaGaagatgttctggtccaccag	12	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:1778571G>T	ENST00000236671.2	-	5	819	c.687C>A	c.(685-687)ttC>ttA	p.F229L	RP11-295K3.1_ENST00000427721.1_Missense_Mutation_p.S100Y	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	229			F -> I (in CLN10).		cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTAGAAGGAGAAGATGTTCT	0.637													13	29					4.3838e-07	4.998e-07	1	1	0	T	1778571	G	T	1778571	3	4	48	1	0	0	0	0	1	0	0	0	4056	933	33	2	571	2	CTSD	11	1778571	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	318954	1778571	133227945	2528	6922										
NUP98	4928	broad.mit.edu	37	chr11	3781836	3781836	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcttccaaatgtagtaagCttgttattgccaaacagggt	9	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:3781836C>T	ENST00000324932.7	-	10	1527	c.1107G>A	c.(1105-1107)aaG>aaA	p.K369K	NUP98_ENST00000355260.3_Silent_p.K369K|NUP98_ENST00000397007.4_Silent_p.K369K|NUP98_ENST00000397004.4_Silent_p.K369K|NUP98_ENST00000359171.4_Silent_p.K369K	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	369	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ATGTAGTAAGCTTGTTATTGC	0.383			T	"HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"	AML								16	44					0	0	1	0	0	T	3781836	C	T	3781836	2	4	48	1	0	0	0	0	0	0	0	1	10820	796	28	3		3	NUP98	11	3781836	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2003265	3781836	131224680	2529	6923										
RHOG	391	broad.mit.edu	37	chr11	3849145	3849145	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacagatgacgaaaacgttgGtctgagggtaggagagtgta	15	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:3849145G>T	ENST00000351018.4	-	2	381	c.224C>A	c.(223-225)aCc>aAc	p.T75N	RHOG_ENST00000533217.1_Missense_Mutation_p.T75N|RHOG_ENST00000396978.1_Missense_Mutation_p.T75N|RHOG_ENST00000396979.1_Missense_Mutation_p.T75N	NM_001665.3	NP_001656.2	P84095	RHOG_HUMAN	ras homolog family member G	75					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(2)	2		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		GAAAACGTTGGTCTGAGGGTA	0.597													20	54					0.000175454	0.000188314	1	1	0	T	3849145	G	T	3849145	3	4	48	1	0	0	0	0	1	0	0	0	13388	1261	44	5	355	5	RHOG	11	3849145	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	67309	3849145	131157371	2530	6924										
TRIM68	55128	broad.mit.edu	37	chr11	4623410	4623410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagcggacaggcctctgcGacctctctttcaactctgca	8	16	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:4623410G>A	ENST00000300747.5	-	4	1044	c.755C>T	c.(754-756)tCg>tTg	p.S252L		NM_018073.6	NP_060543.5	Q6AZZ1	TRI68_HUMAN	tripartite motif containing 68	252					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		AGGCCTCTGCGACCTCTCTTT	0.537													31	47					0	0	1	0	0	A	4623410	G	A	4623410	3	1	48	1	0	0	0	0	1	0	0	0	16601	1059	37	1	718	1	TRIM68	11	4623410	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	774265	4623410	130383106	2531	6925										
OR51E2	81285	broad.mit.edu	37	chr11	4703813	4703813	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtccttacgatgaagaccacGatgcagtttccaaacattgc	8	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:4703813G>T	ENST00000396950.3	-	2	368	c.129C>A	c.(127-129)atC>atA	p.I43I		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGAAGACCACGATGCAGTTTC	0.507													35	67					9.65963e-10	1.17364e-09	1	1	0	T	4703813	G	T	4703813	2	4	48	1	0	0	0	0	0	0	0	1	11142	1048	37	2		2	OR51E2	11	4703813	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	80403	4703813	130302703	2532	6926										
OR51S1	119692	broad.mit.edu	37	chr11	4869969	4869969	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagacccaggcatcgaaaaGaaatggccaggctgattttg	13	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:4869969G>T	ENST00000322101.2	-	1	545	c.470C>A	c.(469-471)tCt>tAt	p.S157Y	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S157F(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCATCGAAAAGAAATGGCCAG	0.552													55	93					1.07234e-20	1.47176e-20	1	1	0	T	4869969	G	T	4869969	3	4	48	1	0	0	0	0	1	0	0	0	11152	942	33	2	504	2	OR51S1	11	4869969	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	166156	4869969	130136547	2533	6927										
OR51G1	79324	broad.mit.edu	37	chr11	4945040	4945040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgaagacaataagcatgaGccagcacatgggagtggcag	15	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:4945040G>A	ENST00000321961.2	-	1	597	c.530C>T	c.(529-531)gCt>gTt	p.A177V	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAAGCATGAGCCAGCACATG	0.522													15	41					0	0	1	0	0	A	4945040	G	A	4945040	3	1	48	1	0	0	0	0	1	0	0	0	11145	971	34	3	437	3	OR51G1	11	4945040	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	75071	4945040	130061476	2534	6928										
MMP26	56547	broad.mit.edu	37	chr11	5013298	5013298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accccacttactggtatcacGaccctagaaccttccagctc	5	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5013298G>A	ENST00000380390.1	+	6	916	c.700G>A	c.(700-702)Gac>Aac	p.D234N	MMP26_ENST00000300762.1_Missense_Mutation_p.D234N			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	234					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTGGTATCACGACCCTAGAAC	0.488													19	27					0	0	1	0	0	A	5013298	G	A	5013298	3	1	48	1	0	0	0	0	1	0	0	0	9711	1058	37	1	718	1	MMP26	11	5013298	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	68258	5013298	129993218	2535	6929										
OR52A5	390054	broad.mit.edu	37	chr11	5153355	5153355	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgagagatgactgtagttCgatagtgtttcagacagcat	12	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5153355C>T	ENST00000307388.1	-	1	517	c.518G>A	c.(517-519)cGa>cAa	p.R173Q		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R173Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GACTGTAGTTCGATAGTGTTT	0.448													34	76					0	0	1	0	0	T	5153355	C	T	5153355	3	4	48	1	0	0	0	0	1	0	0	0	11157	884	31	1	435	1	OR52A5	11	5153355	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140057	5153355	129853161	2536	6930										
HBD	3045	broad.mit.edu	37	chr11	5254275	5254275	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcatttgtggggtgaattcCttgccaaagttgcgggccag	14	8	0	1	rs148878316	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5254275C>A	ENST00000380299.3	-	3	577	c.363G>T	c.(361-363)aaG>aaT	p.K121N	HBD_ENST00000292901.3_Intron	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	121					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGTGAATTCCTTGCCAAAGT	0.512													32	58					2.85442e-18	3.86477e-18	1	1	0	A	5254275	C	A	5254275	3	1	48	1	0	0	0	0	1	0	0	0	7019	680	24	5	84	5	HBD	11	5254275	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	100920	5254275	129752241	2537	6931										
HBG1	3047	broad.mit.edu	37	chr11	5269669	5269669	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcacctcaggggtgaattCtttgccgaaatggattgcca	11	10	2	1	rs34647752		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5269669C>A	ENST00000330597.3	-	3	451	c.364G>T	c.(364-366)Gaa>Taa	p.E122*		NM_000559.2	NP_000550.2	P69891	HBG1_HUMAN	hemoglobin, gamma A	122			E -> K (in Siena/Hull).		blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding			large_intestine(1)|lung(3)|skin(1)	5		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGTGAATTCTTTGCCGAAA	0.517													27	29					8.16721e-17	1.09032e-16	1	1	0	A	5269669	C	A	5269669	4	1	48	1	0	0	0	0	0	1	0	0	7022	922	32	2	83	2	HBG1	11	5269669	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15394	5269669	129736847	2538	6932										
TRIM6-TRIM34	0	broad.mit.edu	37	chr11	5664849	5664849	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctccctcatttacaagttCtctaaatgttgcttttctca	5	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5664849C>A	ENST00000354852.5	+	14	2612	c.2439C>A	c.(2437-2439)ttC>ttA	p.F813L	TRIM34_ENST00000514226.1_Missense_Mutation_p.F459L|TRIM34_ENST00000495668.1_3'UTR|HBG2_ENST00000380259.2_Intron|TRIM6-TRIM34_ENST00000457787.2_Missense_Mutation_p.F459L|TRIM34_ENST00000429814.2_Missense_Mutation_p.F459L	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		813						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		TTTACAAGTTCTCTAAATGTT	0.453													38	105					4.62619e-21	6.37263e-21	1	1	0	A	5664849	C	A	5664849	3	1	48	1	0	0	0	0	1	0	0	0	16594	912	32	2	2466	2	TRIM6-TRIM34	11	5664849	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	395180	5664849	129341667	2539	6933										
TRIM5	85363	broad.mit.edu	37	chr11	5699533	5699533	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accatctcagtttcagagttCgtaaggcttttcagaatgtc	8	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5699533C>T	ENST00000305836.5	-	4	947	c.645G>A	c.(643-645)acG>acA	p.T215T	TRIM5_ENST00000396855.3_Silent_p.T215T|TRIM5_ENST00000396853.4_Silent_p.T215T|TRIM5_ENST00000380034.3_Silent_p.T215T|TRIM5_ENST00000396847.3_Silent_p.T215T|TRIM5_ENST00000483835.1_5'UTR|TRIM5_ENST00000380027.1_Silent_p.T215T			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	215					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TTTCAGAGTTCGTAAGGCTTT	0.527													8	50					0	0	1	0	0	T	5699533	C	T	5699533	2	4	48	1	0	0	0	0	0	0	0	1	16585	871	31	1		1	TRIM5	11	5699533	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34684	5699533	129306983	2540	6934										
OR52N5	390075	broad.mit.edu	37	chr11	5798916	5798916	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacccttatcaccctggaAgaactttatgacactcttgc	6	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5798916A>C	ENST00000317093.2	-	1	981	c.949T>G	c.(949-951)Ttc>Gtc	p.F317V	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	317					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		TCACCCTGGAAGAACTTTATG	0.348													7	49					0	0	1	0	0	C	5798916	A	C	5798916	3	2	48	1	0	0	0	0	1	0	0	0	11177	72	3	4	29	4	OR52N5	11	5798916	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	99383	5798916	129207600	2541	6935										
OR52N1	79473	broad.mit.edu	37	chr11	5809140	5809140	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacctaatgacactttctcGtacctgcctggttttcaccc	6	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5809140G>A	ENST00000317078.1	-	1	906	c.907C>T	c.(907-909)Cga>Tga	p.R303*	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ACACTTTCTCGTACCTGCCTG	0.388													54	87					0	0	1	0	0	A	5809140	G	A	5809140	4	1	48	1	0	0	0	0	0	1	0	0	11174	1153	40	1	58	1	OR52N1	11	5809140	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10224	5809140	129197376	2542	6936										
OR52E6	390078	broad.mit.edu	37	chr11	5862509	5862509	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcacatccaataacaagaGagaaatactgccaagaccaa	7	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:5862509G>T	ENST00000329322.5	-	1	618	c.619C>A	c.(619-621)Ctc>Atc	p.L207I	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Missense_Mutation_p.L211I	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AATAACAAGAGAGAAATACTG	0.473													20	44					2.4624e-09	2.95225e-09	1	1	0	T	5862509	G	T	5862509	3	4	48	1	0	0	0	0	1	0	0	0	11164	942	33	2	324	2	OR52E6	11	5862509	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53369	5862509	129144007	2543	6937										
OR56A4	120793	broad.mit.edu	37	chr11	6023301	6023301	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacaacctcttcagcaggtTttggattccctgcttgatct	7	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:6023301T>G	ENST00000330728.4	-	1	1123	c.1078A>C	c.(1078-1080)Aac>Cac	p.N360H		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCAGCAGGTTTTGGATTCCC	0.418													17	32					0	0	1	0	0	G	6023301	T	G	6023301	3	3	48	1	0	0	0	0	1	0	0	0	11182	1841	64	4	21	4	OR56A4	11	6023301	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	160792	6023301	128983215	2544	6938										
FAM160A2	84067	broad.mit.edu	37	chr11	6244441	6244441	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcgaggcagtgatgagtAcagggcactgagccctgtgg	15	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:6244441A>G	ENST00000265978.4	-	4	1163	c.805T>C	c.(805-807)Tac>Cac	p.Y269H	FAM160A2_ENST00000524416.1_Missense_Mutation_p.Y269H|FAM160A2_ENST00000449352.2_Missense_Mutation_p.Y269H	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	269					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGTGATGAGTACAGGGCACTG	0.478													20	168					0	0	1	0	0	G	6244441	A	G	6244441	3	3	48	1	0	0	0	0	1	0	0	0	5499	391	14	4	2191	4	FAM160A2	11	6244441	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	221140	6244441	128762075	2545	6939										
OR2D3	120775	broad.mit.edu	37	chr11	6943085	6943085	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaactccaagactacaaaaGaactggataaaatgatatct	5	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:6943085G>T	ENST00000317834.3	+	1	881	c.853G>T	c.(853-855)Gaa>Taa	p.E285*		NM_001004684.1	NP_001004684.1	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D, member 3	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|prostate(3)|skin(1)|stomach(1)	27		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GACTACAAAAGAACTGGATAA	0.423													30	42					2.47511e-08	2.91589e-08	1	1	0	T	6943085	G	T	6943085	4	4	48	1	0	0	0	0	0	1	0	0	11042	943	33	2	855	2	OR2D3	11	6943085	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	698644	6943085	128063431	2546	6940										
NLRP14	338323	broad.mit.edu	37	chr11	7060094	7060094	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgtgtgagagagcgaaaGaagagatcaactgtgagtga	14	4	2	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7060094G>T	ENST00000299481.4	+	2	623	c.277G>T	c.(277-279)Gaa>Taa	p.E93*		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	93	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GAGAGCGAAAGAAGAGATCAA	0.458													5	37					1	1	1	1	0	T	7060094	G	T	7060094	4	4	48	1	0	0	0	0	0	1	0	0	10522	943	33	2	279	2	NLRP14	11	7060094	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	117009	7060094	127946422	2547	6941										
NLRP14	338323	broad.mit.edu	37	chr11	7063935	7063935	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaattaaccagctgaaagaGagaagctttgctcaattgat	9	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7063935G>T	ENST00000299481.4	+	4	1024	c.678G>T	c.(676-678)gaG>gaT	p.E226D		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	226	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGCTGAAAGAGAGAAGCTTTG	0.423													36	74					4.34311e-12	5.44389e-12	1	1	0	T	7063935	G	T	7063935	3	4	48	1	0	0	0	0	1	0	0	0	10522	933	33	2	688	2	NLRP14	11	7063935	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3841	7063935	127942581	2548	6942										
OLFML1	283298	broad.mit.edu	37	chr11	7531307	7531307	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcttccccaagagaccaaGaagtcactccatgatccatt	6	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7531307G>T	ENST00000329293.3	+	3	1491	c.1097G>T	c.(1096-1098)aGa>aTa	p.R366I	OLFML1_ENST00000528758.1_3'UTR|OLFML1_ENST00000530135.1_Missense_Mutation_p.R366I|CTD-2516F10.2_ENST00000530201.1_RNA	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	366	Olfactomedin-like.					extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		AAGAGACCAAGAAGTCACTCC	0.498													24	43					5.35356e-11	6.62625e-11	1	1	0	T	7531307	G	T	7531307	3	4	48	1	0	0	0	0	1	0	0	0	10903	942	33	2	1107	2	OLFML1	11	7531307	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	467372	7531307	127475209	2549	6943										
PPFIBP2	8495	broad.mit.edu	37	chr11	7663587	7663587	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctggggatggcagagtttCgacgaggtgggctccgggca	19	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7663587C>T	ENST00000299492.4	+	17	1964	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	PPFIBP2_ENST00000530181.1_Nonsense_Mutation_p.R383*|PPFIBP2_ENST00000528883.1_Nonsense_Mutation_p.R414*|PPFIBP2_ENST00000533792.1_Nonsense_Mutation_p.R368*|PPFIBP2_ENST00000530582.1_3'UTR	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	526					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GGCAGAGTTTCGACGAGGTGG	0.527													11	21					0	0	1	0	0	T	7663587	C	T	7663587	4	4	48	1	0	0	0	0	0	1	0	0	12358	876	31	1	1638	1	PPFIBP2	11	7663587	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	132280	7663587	127342929	2550	6944										
OR5P2	120065	broad.mit.edu	37	chr11	7817521	7817521	+	Nonstop_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaagagaagagatagggttCtatgtaatatcattatttga	9	3	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7817521C>A	ENST00000329434.2	-	1	999	c.969G>T	c.(967-969)taG>taT	p.*323Y	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGATAGGGTTCTATGTAATAT	0.348													33	65					1.06647e-15	1.40869e-15	1	1	0	A	7817521	C	A	7817521	4	1	48	1	0	0	0	0	0	0	0	0	11224	927	32	2	3	2	OR5P2	11	7817521	Nonstop_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	153934	7817521	127188995	2551	6945										
NLRP10	338322	broad.mit.edu	37	chr11	7982477	7982477	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaggggcttgattgtcccCgcagcaccagaaaaggagct	13	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7982477C>T	ENST00000328600.2	-	2	843	c.682G>A	c.(682-684)Ggg>Agg	p.G228R		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	228	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGATTGTCCCCGCAGCACCAG	0.522													17	36					0	0	1	0	0	T	7982477	C	T	7982477	3	4	48	1	0	0	0	0	1	0	0	0	10518	652	23	1	1289	1	NLRP10	11	7982477	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	164956	7982477	127024039	2552	6946			2	10		4	4	383	N	T_C	2.810816e-05
NLRP10	338322	broad.mit.edu	37	chr11	7982699	7982699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcccctgaatcaaatagagCctccaccgtgacagactcca	6	15	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7982699C>T	ENST00000328600.2	-	2	621	c.460G>A	c.(460-462)Gct>Act	p.A154T		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	154							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCAAATAGAGCCTCCACCGTG	0.572													25	52					0	0	1	0	0	T	7982699	C	T	7982699	3	4	48	1	0	0	0	0	1	0	0	0	10518	739	26	3	1511	3	NLRP10	11	7982699	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	222	7982699	127023817	2553	6947			2	10		4	4	383	N	T_C	2.810816e-05
NLRP10	338322	broad.mit.edu	37	chr11	7982839	7982839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgccattcctctaggcagCgcacatgctctcggtatact	8	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7982839C>T	ENST00000328600.2	-	2	481	c.320G>A	c.(319-321)cGc>cAc	p.R107H		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	107							ATP binding	p.R107H(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCTAGGCAGCGCACATGCTC	0.507													4	80					0	0	1	0	0	T	7982839	C	T	7982839	3	4	48	1	0	0	0	0	1	0	0	0	10518	768	27	1	1651	1	NLRP10	11	7982839	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140	7982839	127023677	2554	6948			2	10		4	4	383	N	T_C	2.810816e-05
NLRP10	338322	broad.mit.edu	37	chr11	7982859	7982859	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcacatgctctcggtatacTtctctgtaatctgagccaaa	7	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:7982859T>G	ENST00000328600.2	-	2	461	c.300A>C	c.(298-300)gaA>gaC	p.E100D		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	100							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCGGTATACTTCTCTGTAAT	0.493													19	45					0	0	1	0	0	G	7982859	T	G	7982859	3	3	48	1	0	0	0	0	1	0	0	0	10518	1606	56	4	1671	4	NLRP10	11	7982859	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	20	7982859	127023657	2555	6949			2	10		4	4	383	N	T_C	2.810816e-05
EIF3F	8665	broad.mit.edu	37	chr11	8013686	8013686	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaactgcataaaaaagtttCtccaaatgagctcatcctgg	7	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:8013686C>A	ENST00000533626.1	+	5	1117	c.491C>A	c.(490-492)tCt>tAt	p.S164Y	EIF3F_ENST00000449102.2_Missense_Mutation_p.S15Y|EIF3F_ENST00000309828.4_Missense_Mutation_p.S164Y|EIF3F_ENST00000537635.1_Missense_Mutation_p.S179Y			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	164	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAAAAAGTTTCTCCAAATGAG	0.478													10	15					1.76689e-08	2.08373e-08	1	1	0	A	8013686	C	A	8013686	3	1	48	1	0	0	0	0	1	0	0	0	5044	913	32	2	501	2	EIF3F	11	8013686	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30827	8013686	126992830	2556	6950										
SCUBE2	57758	broad.mit.edu	37	chr11	9069544	9069544	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaacagtgataaacatttCcttaggggtgcttggtcggc	11	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:9069544C>T	ENST00000457346.2	-	15	1815	c.1741G>A	c.(1741-1743)Gaa>Aaa	p.E581K	RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000520467.1_Missense_Mutation_p.E581K|SCUBE2_ENST00000450649.2_Intron|SCUBE2_ENST00000309263.3_Missense_Mutation_p.E552K			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	552						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ATAAACATTTCCTTAGGGGTG	0.498													77	135					0	0	1	0	0	T	9069544	C	T	9069544	3	4	48	1	0	0	0	0	1	0	0	0	13998	864	30	3	1381	3	SCUBE2	11	9069544	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1055858	9069544	125936972	2557	6951										
WEE1	7465	broad.mit.edu	37	chr11	9598080	9598080	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagtcccggtatacaacagAatttcatgagctagagaaaa	9	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:9598080A>C	ENST00000299613.6	+	4	1006	c.251A>C	c.(250-252)gAa>gCa	p.E84A	WEE1_ENST00000450114.2_Missense_Mutation_p.E298A	NM_001143976.1	NP_001137448.1	P30291	WEE1_HUMAN	WEE1 G2 checkpoint kinase	298					blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	23				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TATACAACAGAATTTCATGAG	0.333													6	53					0	0	1	0	0	C	9598080	A	C	9598080	3	2	48	1	0	0	0	0	1	0	0	0	17403	246	9	4	907	4	WEE1	11	9598080	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	528536	9598080	125408436	2558	6952										
SBF2	81846	broad.mit.edu	37	chr11	9829665	9829665	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagagccactctttttcaAccaacatctggaagccttca	6	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:9829665A>G	ENST00000256190.8	-	32	4462	c.4325T>C	c.(4324-4326)gTt>gCt	p.V1442A	SBF2-AS1_ENST00000498905.2_RNA|SBF2-AS1_ENST00000534671.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1442	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTCTTTTTCAACCAACATCTG	0.453													9	20					0	0	1	0	0	G	9829665	A	G	9829665	3	3	48	1	0	0	0	0	1	0	0	0	13911	43	2	4	1260	4	SBF2	11	9829665	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	231585	9829665	125176851	2559	6953										
AMPD3	272	broad.mit.edu	37	chr11	10521689	10521689	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagcgaccacatgttttcCgacaagagcccaaacccgga	8	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:10521689C>T	ENST00000444303.2	+	10	1609	c.1137C>T	c.(1135-1137)tcC>tcT	p.S379S	AMPD3_ENST00000530864.1_3'UTR|AMPD3_ENST00000396554.3_Silent_p.S547S	NM_001172431.1	NP_001165902.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	538					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		ACATGTTTTCCGACAAGAGCC	0.567													29	70					0	0	1	0	0	T	10521689	C	T	10521689	2	4	48	1	0	0	0	0	0	0	0	1	583	639	23	1		1	AMPD3	11	10521689	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	692024	10521689	124484827	2560	6954										
MRVI1	10335	broad.mit.edu	37	chr11	10653561	10653561	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagatgtcagggaggcagtgGacaccttcaagtgtcggtga	15	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:10653561G>A	ENST00000547195.1	-	3	604	c.104C>T	c.(103-105)tCc>tTc	p.S35F	MRVI1_ENST00000545852.1_5'UTR|MRVI1_ENST00000436272.1_Missense_Mutation_p.S117F|MRVI1_ENST00000534266.2_5'UTR|MRVI1_ENST00000552103.1_Missense_Mutation_p.S35F|MRVI1_ENST00000421747.1_Missense_Mutation_p.S117F|MRVI1_ENST00000527509.2_Missense_Mutation_p.S35F|MRVI1_ENST00000541483.1_Missense_Mutation_p.S126F|MRVI1_ENST00000532037.1_5'UTR|MRVI1_ENST00000531107.1_Missense_Mutation_p.S117F|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000423302.2_Missense_Mutation_p.S126F|MRVI1_ENST00000558540.1_5'UTR	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	117					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		GGAGGCAGTGGACACCTTCAA	0.493													14	32					0	0	1	0	0	A	10653561	G	A	10653561	3	1	48	1	0	0	0	0	1	0	0	0	9901	1174	41	3	2433	3	MRVI1	11	10653561	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	131872	10653561	124352955	2561	6955										
CTR9	9646	broad.mit.edu	37	chr11	10785209	10785209	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagattatgaccaagcttTtcagtactattatcaagcca	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:10785209T>C	ENST00000361367.2	+	9	1403	c.977T>C	c.(976-978)tTt>tCt	p.F326S		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	326					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GACCAAGCTTTTCAGTACTAT	0.313													14	29					0	0	1	0	0	C	10785209	T	C	10785209	3	2	48	1	0	0	0	0	1	0	0	0	4048	1841	64	4	1011	4	CTR9	11	10785209	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	131648	10785209	124221307	2562	6956										
USP47	55031	broad.mit.edu	37	chr11	11941759	11941759	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggatggcccaaatcagtaTttttgtgaacgttgtaagaa	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:11941759T>G	ENST00000339865.5	+	8	1585	c.822T>G	c.(820-822)taT>taG	p.Y274*	USP47_ENST00000399455.2_Nonsense_Mutation_p.Y362*|USP47_ENST00000527733.1_Nonsense_Mutation_p.Y342*|USP47_ENST00000539466.1_De_novo_Start_OutOfFrame	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	362					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		CAAATCAGTATTTTTGTGAAC	0.313													4	70					0	0	1	0	0	G	11941759	T	G	11941759	4	3	48	1	0	0	0	0	0	1	0	0	17137	1500	52	4	852	4	USP47	11	11941759	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1156550	11941759	123064757	2563	6957										
USP47	55031	broad.mit.edu	37	chr11	11970032	11970032	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttaacttatagattacaaTtagactggggagagcactta	8	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:11970032T>G	ENST00000339865.5	+	21	3834	c.3071T>G	c.(3070-3072)aTt>aGt	p.I1024S	USP47_ENST00000399455.2_Missense_Mutation_p.I1112S|USP47_ENST00000527733.1_Missense_Mutation_p.I1092S|USP47_ENST00000539466.1_De_novo_Start_InFrame	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	1112					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		TAGATTACAATTAGACTGGGG	0.308													9	28					0	0	1	0	0	G	11970032	T	G	11970032	3	3	48	1	0	0	0	0	1	0	0	0	17137	1493	52	4	3153	4	USP47	11	11970032	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	28273	11970032	123036484	2564	6958										
MICAL2	9645	broad.mit.edu	37	chr11	12243276	12243276	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgaagagctggaaccaggGcacccctcccctggagctgc	14	14	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:12243276G>A	ENST00000256194.4	+	10	1580	c.1292G>A	c.(1291-1293)gGc>gAc	p.G431D	MICAL2_ENST00000527546.1_Missense_Mutation_p.G431D|MICAL2_ENST00000379612.3_Missense_Mutation_p.G431D|MICAL2_ENST00000342902.5_Missense_Mutation_p.G431D|MICAL2_ENST00000537344.1_Missense_Mutation_p.G431D	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	431						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		TGGAACCAGGGCACCCCTCCC	0.602													7	87					0	0	1	0	0	A	12243276	G	A	12243276	3	1	48	1	0	0	0	0	1	0	0	0	9617	1203	42	3	1322	3	MICAL2	11	12243276	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	273244	12243276	122763240	2565	6959										
FAR1	84188	broad.mit.edu	37	chr11	13733490	13733490	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaggcagggaaaggaattCttcgaacaatacgtgcctcc	10	10	1	0	rs150190417		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:13733490C>A	ENST00000354817.3	+	7	928	c.784C>A	c.(784-786)Ctt>Att	p.L262I	FAR1_ENST00000527202.1_3'UTR	NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	262					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding	p.L262F(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						GAAAGGAATTCTTCGAACAAT	0.368													10	30					1.33987e-11	1.67053e-11	1	1	0	A	13733490	C	A	13733490	3	1	48	1	0	0	0	0	1	0	0	0	5706	913	32	2	806	2	FAR1	11	13733490	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1490214	13733490	121273026	2566	6960										
FAR1	84188	broad.mit.edu	37	chr11	13736094	13736094	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcaagaggaatcctctcGaacaggccttcagacggccc	9	14	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:13736094G>A	ENST00000354817.3	+	9	1138	c.994G>A	c.(994-996)Gaa>Aaa	p.E332K	FAR1_ENST00000527202.1_3'UTR	NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	332					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						GAATCCTCTCGAACAGGCCTT	0.378													6	26					0	0	1	0	0	A	13736094	G	A	13736094	3	1	48	1	0	0	0	0	1	0	0	0	5706	1059	37	1	1024	1	FAR1	11	13736094	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2604	13736094	121270422	2567	6961										
COPB1	1315	broad.mit.edu	37	chr11	14480092	14480092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttacctggctctttgcacGaattcttatatggccggtaa	9	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:14480092G>A	ENST00000249923.3	-	21	3088	c.2788C>T	c.(2788-2790)Cgt>Tgt	p.R930C	COPB1_ENST00000439561.2_Missense_Mutation_p.R930C	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	930					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						CTCTTTGCACGAATTCTTATA	0.413													37	55					0	0	1	0	0	A	14480092	G	A	14480092	3	1	48	1	0	0	0	0	1	0	0	0	3751	1058	37	1	81	1	COPB1	11	14480092	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	743998	14480092	120526424	2568	6962										
PDE3B	5140	broad.mit.edu	37	chr11	14666087	14666087	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggctcctggtggctgctgGcgctgcccgcctgctgttac	15	15	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:14666087G>T	ENST00000282096.4	+	1	819	c.466G>T	c.(466-468)Gcg>Tcg	p.A156S	PDE3B_ENST00000534317.1_3'UTR|PDE3B_ENST00000455098.2_Missense_Mutation_p.A156S	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	156					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTGGCTGCTGGCGCTGCCCGC	0.701													9	19					3.09899e-07	3.54467e-07	1	1	0	T	14666087	G	T	14666087	3	4	48	1	0	0	0	0	1	0	0	0	11684	1203	42	5	468	5	PDE3B	11	14666087	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	185995	14666087	120340429	2569	6963										
PIK3C2A	5286	broad.mit.edu	37	chr11	17141460	17141460	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatattttaggaagacaatTtgggtgtttgaagcaataat	9	2	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:17141460T>C	ENST00000265970.7	-	15	2718	c.2719A>G	c.(2719-2721)Aat>Gat	p.N907D	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.N527D|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	907					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	GGAAGACAATTTGGGTGTTTG	0.353													22	40					0	0	1	0	0	C	17141460	T	C	17141460	3	2	48	1	0	0	0	0	1	0	0	0	11956	1841	64	4	2413	4	PIK3C2A	11	17141460	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2475373	17141460	117865056	2570	6964										
ABCC8	6833	broad.mit.edu	37	chr11	17428261	17428261	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccacagtgacagacgtgacGaggcacagcacaatgcccag	11	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:17428261G>A	ENST00000302539.4	-	26	3365	c.3240C>T	c.(3238-3240)ctC>ctT	p.L1080L	ABCC8_ENST00000389817.3_Silent_p.L1079L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1079	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CAGACGTGACGAGGCACAGCA	0.587													10	102					0	0	1	0	0	A	17428261	G	A	17428261	2	1	48	1	0	0	0	0	0	0	0	1	58	1045	37	1		1	ABCC8	11	17428261	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	286801	17428261	117578255	2571	6965										
ABCC8	6833	broad.mit.edu	37	chr11	17448598	17448598	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaggatacatgtattacctGctccagaagacagcccctga	9	11	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:17448598G>A	ENST00000302539.4	-	16	2345	c.2220C>T	c.(2218-2220)agC>agT	p.S740S	ABCC8_ENST00000389817.3_Silent_p.S740S	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	740	ABC transporter 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGTATTACCTGCTCCAGAAGA	0.557													15	25					0	0	1	0	0	A	17448598	G	A	17448598	2	1	48	1	0	0	0	0	0	0	0	1	58	1310	46	3		3	ABCC8	11	17448598	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	20337	17448598	117557918	2572	6966										
TPH1	7166	broad.mit.edu	37	chr11	18057674	18057674	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgggactcgatatgtaacaGattcacatgcttctcctgtg	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:18057674G>A	ENST00000250018.2	-	2	695	c.133C>T	c.(133-135)Ctg>Ttg	p.L45L	TPH1_ENST00000341556.2_Silent_p.L45L	NM_004179.2	NP_004170.1	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	45	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(14)|prostate(1)|stomach(1)	25					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	ATATGTAACAGATTCACATGC	0.338													7	10					0	0	1	0	0	A	18057674	G	A	18057674	2	1	48	1	0	0	0	0	0	0	0	1	16461	933	33	3		3	TPH1	11	18057674	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	609076	18057674	116948842	2573	6967										
TSG101	7251	broad.mit.edu	37	chr11	18524068	18524068	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggctgagaagggtactgaGaacttgttgtggcaggatat	16	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:18524068G>T	ENST00000536719.1	-	7	739	c.605C>A	c.(604-606)tCt>tAt	p.S202Y	TSG101_ENST00000251968.3_Missense_Mutation_p.S202Y|TSG101_ENST00000543087.1_5'UTR|TSG101_ENST00000357193.3_Missense_Mutation_p.S97Y			Q99816	TS101_HUMAN	tumor susceptibility 101	202					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						AGGGTACTGAGAACTTGTTGT	0.433													10	18					1.49906e-05	1.64923e-05	1	1	0	T	18524068	G	T	18524068	3	4	48	1	0	0	0	0	1	0	0	0	16676	942	33	2	583	2	TSG101	11	18524068	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	466394	18524068	116482448	2574	6968										
ZDHHC13	54503	broad.mit.edu	37	chr11	19185898	19185898	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggacttcagaacattttgTacatcatgtcttgtgagttt	8	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:19185898T>C	ENST00000446113.2	+	12	1405	c.1284T>C	c.(1282-1284)tgT>tgC	p.C428C	ZDHHC13_ENST00000399351.3_Silent_p.C298C	NM_019028.2	NP_061901.2	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC-type containing 13	428					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						GAACATTTTGTACATCATGTC	0.348													4	13					0	0	1	0	0	C	19185898	T	C	19185898	2	2	48	1	0	0	0	0	0	0	0	1	17660	1644	57	4		4	ZDHHC13	11	19185898	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	661830	19185898	115820618	2575	6969										
E2F8	79733	broad.mit.edu	37	chr11	19247366	19247366	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggactctgcccccagggAtgagcactgcgtgagaggga	15	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:19247366A>G	ENST00000527884.1	-	11	2171	c.1939T>C	c.(1939-1941)Tcc>Ccc	p.S647P	E2F8_ENST00000250024.4_Missense_Mutation_p.S647P|RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000529188.1_5'UTR	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	647					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCCCCCAGGGATGAGCACTGC	0.453													77	149					0	0	1	0	0	G	19247366	A	G	19247366	3	3	48	1	0	0	0	0	1	0	0	0	4899	333	12	4	676	4	E2F8	11	19247366	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	61468	19247366	115759150	2576	6970										
E2F8	79733	broad.mit.edu	37	chr11	19251847	19251847	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgagccattttacttggGaagggtgcagaattctgaga	13	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:19251847G>A	ENST00000527884.1	-	9	1531	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F	E2F8_ENST00000250024.4_Silent_p.F433F|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	433					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTTTACTTGGGAAGGGTGCAG	0.403													17	52					0	0	1	0	0	A	19251847	G	A	19251847	2	1	48	1	0	0	0	0	0	0	0	1	4899	1165	41	3		3	E2F8	11	19251847	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4481	19251847	115754669	2577	6971										
NAV2	89797	broad.mit.edu	37	chr11	20101616	20101616	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccttggtctccaggaaacgGcactgcccagtctgcagacc	11	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:20101616G>A	ENST00000396085.1	+	25	5547	c.5186G>A	c.(5185-5187)gGc>gAc	p.G1729D	NAV2_ENST00000533917.1_Missense_Mutation_p.G793D|NAV2_ENST00000360655.4_Missense_Mutation_p.G1665D|NAV2_ENST00000527559.2_Missense_Mutation_p.G1714D|NAV2_ENST00000396087.3_Missense_Mutation_p.G1785D|NAV2_ENST00000349880.4_Missense_Mutation_p.G1729D|NAV2_ENST00000311043.8_Missense_Mutation_p.G793D|NAV2_ENST00000540292.1_Missense_Mutation_p.G1716D	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1785						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CCAGGAAACGGCACTGCCCAG	0.577													15	33					0	0	1	0	0	A	20101616	G	A	20101616	3	1	48	1	0	0	0	0	1	0	0	0	10231	1203	42	3	5393	3	NAV2	11	20101616	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	849769	20101616	114904900	2578	6972										
NAV2	89797	broad.mit.edu	37	chr11	20124900	20124900	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctggacaacctacaccacGtgagctctctgggagagatc	10	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:20124900G>T	ENST00000396085.1	+	34	6887	c.6526G>T	c.(6526-6528)Gtg>Ttg	p.V2176L	NAV2_ENST00000533917.1_Missense_Mutation_p.V1237L|NAV2_ENST00000360655.4_Missense_Mutation_p.V2109L|NAV2_ENST00000527559.2_Missense_Mutation_p.V2161L|NAV2_ENST00000396087.3_Missense_Mutation_p.V2232L|NAV2_ENST00000349880.4_Missense_Mutation_p.V2173L|NAV2_ENST00000311043.8_Missense_Mutation_p.V1237L|NAV2_ENST00000540292.1_Missense_Mutation_p.V2163L	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2232						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CCTACACCACGTGAGCTCTCT	0.542													31	62					2.20474e-14	2.87106e-14	1	1	0	T	20124900	G	T	20124900	3	4	48	1	0	0	0	0	1	0	0	0	10231	1145	40	5	6765	5	NAV2	11	20124900	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23284	20124900	114881616	2579	6973										
PRMT3	10196	broad.mit.edu	37	chr11	20486022	20486022	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagcatatagattgccataCgacgtctatctcagatttgg	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:20486022C>G	ENST00000331079.6	+	13	1494	c.1277C>G	c.(1276-1278)aCg>aGg	p.T426R	PRMT3_ENST00000437750.2_Missense_Mutation_p.T364R	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	426							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						GATTGCCATACGACGTCTATC	0.318													11	28					0	0	1	0	0	G	20486022	C	G	20486022	3	3	48	1	0	0	0	0	1	0	0	0	12589	536	19	5	1327	5	PRMT3	11	20486022	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	361122	20486022	114520494	2580	6974										
NELL1	4745	broad.mit.edu	37	chr11	20940848	20940848	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgcaaggaataatggatTtacaagagcttttggccaag	12	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:20940848T>C	ENST00000298925.5	+	8	964	c.811T>C	c.(811-813)Tta>Cta	p.L271L	NELL1_ENST00000532434.1_Silent_p.L243L|NELL1_ENST00000357134.5_Silent_p.L243L|NELL1_ENST00000325319.5_Silent_p.L186L			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	243	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AATAATGGATTTACAAGAGCT	0.323													12	41					0	0	1	0	0	C	20940848	T	C	20940848	2	2	48	1	0	0	0	0	0	0	0	1	10379	1838	64	4		4	NELL1	11	20940848	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	454826	20940848	114065668	2581	6975										
FANCF	2188	broad.mit.edu	37	chr11	22647060	22647060	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatccccgagggcccggttCtccagcaggcgcagagagag	15	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:22647060C>A	ENST00000327470.3	-	1	327	c.297G>T	c.(295-297)gaG>gaT	p.E99D	AC103801.2_ENST00000428556.2_Missense_Mutation_p.L2I	NM_022725.3	NP_073562.1	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	99					DNA repair	nucleoplasm	protein binding			kidney(3)|large_intestine(3)|lung(6)|skin(1)	13						GGGCCCGGTTCTCCAGCAGGC	0.662			"N, F"			"AML, leukemia"		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	153					0.00116845	0.00122532	1	1	0	A	22647060	C	A	22647060	3	1	48	1	0	0	0	0	1	0	0	0	5699	912	32	2	831	2	FANCF	11	22647060	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1706212	22647060	112359456	2582	6976										
GAS2	2620	broad.mit.edu	37	chr11	22833502	22833502	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccaactctaaaggacatGaatccagataactacttggt	6	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:22833502G>T	ENST00000454584.2	+	8	1187	c.882G>T	c.(880-882)atG>atT	p.M294I	GAS2_ENST00000278187.3_Missense_Mutation_p.M294I|GAS2_ENST00000433790.1_Missense_Mutation_p.M294I	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	294					cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						TAAAGGACATGAATCCAGATA	0.453													25	42					7.07758e-08	8.2413e-08	1	1	0	T	22833502	G	T	22833502	3	4	48	1	0	0	0	0	1	0	0	0	6284	1290	45	2	908	2	GAS2	11	22833502	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	186442	22833502	112173014	2583	6977										
LUZP2	338645	broad.mit.edu	37	chr11	25004777	25004777	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatcacatcaaatccaactCggatgttactcccacccagg	5	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:25004777C>T	ENST00000533227.1	+	9	732	c.445C>T	c.(445-447)Cgg>Tgg	p.R149W	LUZP2_ENST00000336930.6_Missense_Mutation_p.R235W	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	235						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AAATCCAACTCGGATGTTACT	0.453													24	57					0	0	1	0	0	T	25004777	C	T	25004777	3	4	48	1	0	0	0	0	1	0	0	0	9131	875	31	1	737	1	LUZP2	11	25004777	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2171275	25004777	110001739	2584	6978										
ANO3	63982	broad.mit.edu	37	chr11	26655846	26655846	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagttccatcttctatatcGctttctttttgggaaggtaa	7	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:26655846G>A	ENST00000256737.3	+	19	2821	c.1969G>A	c.(1969-1971)Gct>Act	p.A657T	ANO3_ENST00000537978.1_Missense_Mutation_p.A641T|ANO3_ENST00000531568.1_Missense_Mutation_p.A511T|ANO3_ENST00000525139.1_Missense_Mutation_p.A641T	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	657						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						CTTCTATATCGCTTTCTTTTT	0.358													11	24					0	0	1	0	0	A	26655846	G	A	26655846	3	1	48	1	0	0	0	0	1	0	0	0	692	1087	38	1	2043	1	ANO3	11	26655846	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1651069	26655846	108350670	2585	6979										
BDNF	627	broad.mit.edu	37	chr11	27680092	27680092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagtatgaaataaccataGtaaggaaaaggatggtcatc	9	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:27680092G>A	ENST00000525528.1	-	1	1113	c.20C>T	c.(19-21)aCt>aTt	p.T7I	BDNF-AS_ENST00000499008.3_RNA|BDNF_ENST00000395983.3_Missense_Mutation_p.T7I|BDNF_ENST00000439476.2_Missense_Mutation_p.T7I|BDNF-AS_ENST00000502161.2_RNA|BDNF_ENST00000533246.1_Missense_Mutation_p.T7I|BDNF_ENST00000395981.3_Missense_Mutation_p.T7I|BDNF_ENST00000533131.1_Missense_Mutation_p.T7I|BDNF_ENST00000584049.1_5'UTR|BDNF_ENST00000532997.1_Missense_Mutation_p.T7I|BDNF_ENST00000395980.2_Missense_Mutation_p.T7I|BDNF_ENST00000525950.1_Missense_Mutation_p.T7I|BDNF_ENST00000530861.1_Missense_Mutation_p.T7I|BDNF_ENST00000314915.6_Missense_Mutation_p.T15I|BDNF_ENST00000395986.2_Missense_Mutation_p.T22I|BDNF_ENST00000418212.1_Missense_Mutation_p.T7I|BDNF_ENST00000395978.3_Missense_Mutation_p.T7I|BDNF-AS_ENST00000501176.2_RNA|BDNF_ENST00000356660.4_Missense_Mutation_p.T7I|BDNF_ENST00000420794.1_Missense_Mutation_p.T7I|BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000530313.1_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF_ENST00000438929.1_Missense_Mutation_p.T89I	NM_170735.5	NP_733931.1	P23560	BDNF_HUMAN	brain-derived neurotrophic factor	7						extracellular region	growth factor activity			breast(1)|large_intestine(3)|lung(2)	6						AATAACCATAGTAAGGAAAAG	0.488													43	81					0	0	1	0	0	A	27680092	G	A	27680092	3	1	48	1	0	0	0	0	1	0	0	0	1392	1029	36	3	727	3	BDNF	11	27680092	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1024246	27680092	107326424	2586	6980										
BDNF	627	broad.mit.edu	37	chr11	27695654	27695654	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgttaaattccactgaaaCgtggaggtacacagcacagc	9	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:27695654C>T	ENST00000438929.1	-	2	318	c.178G>A	c.(178-180)Gtt>Att	p.V60I	BDNF-AS_ENST00000499008.3_RNA|BDNF_ENST00000395983.3_Intron|BDNF-AS_ENST00000502161.2_RNA|BDNF_ENST00000533246.1_Intron|BDNF_ENST00000395981.3_Intron|BDNF_ENST00000533131.1_Intron|BDNF_ENST00000584049.1_Intron|BDNF_ENST00000532997.1_Intron|BDNF_ENST00000395980.2_Intron|BDNF_ENST00000525950.1_Intron|BDNF_ENST00000530861.1_Intron|BDNF_ENST00000314915.6_Intron|BDNF_ENST00000395986.2_Intron|BDNF_ENST00000418212.1_Intron|BDNF_ENST00000395978.3_Intron|BDNF-AS_ENST00000501176.2_RNA|BDNF_ENST00000356660.4_Intron|BDNF-AS_ENST00000501663.2_RNA|BDNF_ENST00000420794.1_5'UTR|BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000530686.1_RNA	NM_001143810.1	NP_001137282.1	P23560	BDNF_HUMAN	brain-derived neurotrophic factor	0						extracellular region	growth factor activity			breast(1)|large_intestine(3)|lung(2)	6						TCCACTGAAACGTGGAGGTAC	0.453													8	12					0	0	1	0	0	T	27695654	C	T	27695654	3	4	48	1	0	0	0	0	1	0	0	0	1392	536	19	1	819	1	BDNF	11	27695654	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15562	27695654	107310862	2587	6981										
CCDC73	493860	broad.mit.edu	37	chr11	32637489	32637489	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tataattttaaggttaccatCtataattatttcctctataa	2	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:32637489C>T	ENST00000335185.5	-	15	1415	c.1372G>A	c.(1372-1374)Gat>Aat	p.D458N	CCDC73_ENST00000534415.1_5'UTR	NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	458										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					AGGTTACCATCTATAATTATT	0.269													6	17					0	0	1	0	0	T	32637489	C	T	32637489	3	4	48	1	0	0	0	0	1	0	0	0	2866	913	32	3	1883	3	CCDC73	11	32637489	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4941835	32637489	102369027	2588	6982										
DEPDC7	91614	broad.mit.edu	37	chr11	33054270	33054270	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagctattgttgacaataaAaatttatccaaaggcaaaac	5	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:33054270A>C	ENST00000311388.3	+	7	1543	c.1167A>C	c.(1165-1167)aaA>aaC	p.K389N	DEPDC7_ENST00000241051.3_Missense_Mutation_p.K398N	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	398					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						TTGACAATAAAAATTTATCCA	0.274													27	45					0	0	1	0	0	C	33054270	A	C	33054270	3	2	48	1	0	0	0	0	1	0	0	0	4472	11	1	4	1270	4	DEPDC7	11	33054270	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	416781	33054270	101952246	2589	6983										
TCP11L1	55346	broad.mit.edu	37	chr11	33083232	33083232	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaattacgcttacctgaAgcttctgaagtgggaccacc	9	12	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:33083232A>C	ENST00000334274.4	+	7	1332	c.932A>C	c.(931-933)aAg>aCg	p.K311T	TCP11L1_ENST00000531632.2_Missense_Mutation_p.K311T|TCP11L1_ENST00000432887.1_Missense_Mutation_p.K311T|TCP11L1_ENST00000324357.9_Missense_Mutation_p.K90T	NM_018393.3	NP_060863.3	Q9NUJ3	T11L1_HUMAN	t-complex 11, testis-specific-like 1	311										kidney(1)|liver(2)|lung(2)|skin(1)	6						GCTTACCTGAAGCTTCTGAAG	0.527													8	28					0	0	1	0	0	C	33083232	A	C	33083232	3	2	48	1	0	0	0	0	1	0	0	0	15772	72	3	4	954	4	TCP11L1	11	33083232	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	28962	33083232	101923284	2590	6984										
FBXO3	26273	broad.mit.edu	37	chr11	33763477	33763477	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaaggcgtgagcagcggcGtctgcgaatgggaacatcaa	14	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:33763477G>A	ENST00000526785.1	-	10	4805	c.1054C>T	c.(1054-1056)Cgc>Tgc	p.R352C	FBXO3_ENST00000532057.1_Missense_Mutation_p.R152C|FBXO3_ENST00000531080.1_Missense_Mutation_p.R152C|FBXO3_ENST00000530401.1_3'UTR|FBXO3_ENST00000265651.3_Missense_Mutation_p.R465C			Q9UK99	FBX3_HUMAN	F-box protein 3	465	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		GAGCAGCGGCGTCTGCGAATG	0.428													15	44					0	0	1	0	0	A	33763477	G	A	33763477	3	1	48	1	0	0	0	0	1	0	0	0	5771	1145	40	1	26	1	FBXO3	11	33763477	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	680245	33763477	101243039	2591	6985										
CAPRIN1	4076	broad.mit.edu	37	chr11	34093499	34093499	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataatttggagtttgcaaaaGaattacagaggagtttcatg	10	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:34093499G>T	ENST00000341394.4	+	4	520	c.331G>T	c.(331-333)Gaa>Taa	p.E111*	CAPRIN1_ENST00000529307.1_Nonsense_Mutation_p.E30*|CAPRIN1_ENST00000532820.1_Nonsense_Mutation_p.E111*|CAPRIN1_ENST00000530820.1_Nonsense_Mutation_p.E111*|CAPRIN1_ENST00000389645.3_Nonsense_Mutation_p.E111*	NM_005898.4	NP_005889.3	Q14444	CAPR1_HUMAN	cell cycle associated protein 1	111					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)	18		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				GTTTGCAAAAGAATTACAGAG	0.333													12	8					0.000151284	0.00016287	1	1	0	T	34093499	G	T	34093499	4	4	48	1	0	0	0	0	0	1	0	0	2653	943	33	2	341	2	CAPRIN1	11	34093499	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	330022	34093499	100913017	2592	6986										
SLC1A2	6506	broad.mit.edu	37	chr11	35308373	35308373	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctataaagatggcggctaccGcttcataaagggctgtacca	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:35308373G>A	ENST00000278379.3	-	8	1499	c.1217C>T	c.(1216-1218)gCg>gTg	p.A406V	SLC1A2_ENST00000606205.1_Missense_Mutation_p.A406V|SLC1A2_ENST00000395750.1_Missense_Mutation_p.A397V|SLC1A2_ENST00000395753.1_Missense_Mutation_p.A397V	NM_004171.3	NP_004162.2	P43004	EAA2_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 2	406					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|urinary_tract(1)	24	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	GGCGGCTACCGCTTCATAAAG	0.468													23	115					0	0	1	0	0	A	35308373	G	A	35308373	3	1	48	1	0	0	0	0	1	0	0	0	14486	1087	38	1	523	1	SLC1A2	11	35308373	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1214874	35308373	99698143	2593	6987										
PAMR1	25891	broad.mit.edu	37	chr11	35461197	35461197	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgactgaacctgcatcggaaGaactctccttctcaccaggt	8	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:35461197G>A	ENST00000378880.2	-	8	1523	c.1078C>T	c.(1078-1080)Ctt>Ttt	p.L360F	PAMR1_ENST00000378878.3_Missense_Mutation_p.L249F|PAMR1_ENST00000278360.3_Missense_Mutation_p.L377F|PAMR1_ENST00000532848.1_Missense_Mutation_p.L320F	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	360					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						TGCATCGGAAGAACTCTCCTT	0.453													28	60					0	0	1	0	0	A	35461197	G	A	35461197	3	1	48	1	0	0	0	0	1	0	0	0	11459	942	33	3	1100	3	PAMR1	11	35461197	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	152824	35461197	99545319	2594	6988										
TRAF6	7189	broad.mit.edu	37	chr11	36511925	36511925	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccattgcactgctgtgcttcGatttcagcaactttgtcctc	7	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:36511925G>A	ENST00000526995.1	-	7	1278	c.1032C>T	c.(1030-1032)atC>atT	p.I344I	TRAF6_ENST00000348124.5_Silent_p.I344I	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	344	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				GCTGTGCTTCGATTTCAGCAA	0.408													31	86					0	0	1	0	0	A	36511925	G	A	36511925	2	1	48	1	0	0	0	0	0	0	0	1	16505	1048	37	1		1	TRAF6	11	36511925	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1050728	36511925	98494591	2595	6989										
RAG1	5896	broad.mit.edu	37	chr11	36597386	36597386	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcatctccggaagaagatGaacctcaaaccaatcatgag	8	10	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:36597386G>T	ENST00000299440.5	+	2	2644	c.2532G>T	c.(2530-2532)atG>atT	p.M844I		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	844					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GGAAGAAGATGAACCTCAAAC	0.468									Familial Hemophagocytic Lymphohistiocytosis				17	57					1.5739e-10	1.93697e-10	1	1	0	T	36597386	G	T	36597386	3	4	48	1	0	0	0	0	1	0	0	0	13054	1290	45	2	2534	2	RAG1	11	36597386	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	85461	36597386	98409130	2596	6990										
ACCSL	390110	broad.mit.edu	37	chr11	44076774	44076774	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataacctacatgtgatcataGatgagatttacatgctgtct	7	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:44076774G>T	ENST00000378832.1	+	9	1128	c.1072G>T	c.(1072-1074)Gat>Tat	p.D358Y		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	358							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						TGTGATCATAGATGAGATTTA	0.393													3	14					0.115264	0.116507	1	1	0	T	44076774	G	T	44076774	3	4	48	1	0	0	0	0	1	0	0	0	134	942	33	2	1106	2	ACCSL	11	44076774	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7479388	44076774	90929742	2597	6991										
TSPAN18	90139	broad.mit.edu	37	chr11	44931436	44931436	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggccgtccgtgagaacaagTgtctgctgctatttgtgagt	14	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:44931436T>C	ENST00000340160.3	+	4	483	c.244T>C	c.(244-246)Tgt>Cgt	p.C82R	TSPAN18_ENST00000520358.2_Missense_Mutation_p.C82R	NM_130783.4	NP_570139.3	Q96SJ8	TSN18_HUMAN	tetraspanin 18	82						integral to membrane				endometrium(1)|large_intestine(6)|lung(3)	10						TGAGAACAAGTGTCTGCTGCT	0.647													24	37					0	0	1	0	0	C	44931436	T	C	44931436	3	2	48	1	0	0	0	0	1	0	0	0	16702	1696	59	4	250	4	TSPAN18	11	44931436	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	854662	44931436	90075080	2598	6992										
CRY2	1408	broad.mit.edu	37	chr11	45882464	45882464	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcaggccatcatcagccGcatggagctgcccaagaagc	10	14	3	1	rs144003583	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:45882464G>A	ENST00000443527.2	+	4	618	c.596G>A	c.(595-597)cGc>cAc	p.R199H	CRY2_ENST00000417225.2_Missense_Mutation_p.R117H|CRY2_ENST00000473199.1_Intron	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	178					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						ATCATCAGCCGCATGGAGCTG	0.582													35	63					0	0	1	0	0	A	45882464	G	A	45882464	3	1	48	1	0	0	0	0	1	0	0	0	3927	1087	38	1	646	1	CRY2	11	45882464	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	951028	45882464	89124052	2599	6993										
CKAP5	9793	broad.mit.edu	37	chr11	46799031	46799031	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatagggatgcctaaattTtttacatgttgcttaatatt	7	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:46799031T>G	ENST00000529230.1	-	23	2866	c.2820A>C	c.(2818-2820)aaA>aaC	p.K940N	CKAP5_ENST00000354558.3_Missense_Mutation_p.K940N|CKAP5_ENST00000415402.1_Missense_Mutation_p.K940N|CKAP5_ENST00000312055.5_Missense_Mutation_p.K940N			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	940					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TGCCTAAATTTTTTACATGTT	0.428													18	27					0	0	1	0	0	G	46799031	T	G	46799031	3	3	48	1	0	0	0	0	1	0	0	0	3468	1838	64	4	3366	4	CKAP5	11	46799031	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	916567	46799031	88207485	2600	6994										
LRP4	4038	broad.mit.edu	37	chr11	46921846	46921846	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccgagtcatcctcacagtCgttgtccccgtcacacaccc	6	18	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:46921846C>T	ENST00000378623.1	-	3	525	c.283G>A	c.(283-285)Gac>Aac	p.D95N		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	95	LDL-receptor class A 2.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TCCTCACAGTCGTTGTCCCCG	0.527													45	70					0	0	1	0	0	T	46921846	C	T	46921846	3	4	48	1	0	0	0	0	1	0	0	0	9003	884	31	1	5578	1	LRP4	11	46921846	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	122815	46921846	88084670	2601	6995										
MADD	8567	broad.mit.edu	37	chr11	47297547	47297547	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agattgaggcctggatctatCgattgctgcgctccccagta	11	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:47297547C>T	ENST00000342922.4	+	4	1114	c.757C>T	c.(757-759)Cga>Tga	p.R253*	MADD_ENST00000402192.2_Nonsense_Mutation_p.R253*|MADD_ENST00000407859.3_Nonsense_Mutation_p.R253*|MADD_ENST00000402799.1_Nonsense_Mutation_p.R253*|MADD_ENST00000349238.3_Nonsense_Mutation_p.R253*|MADD_ENST00000395344.3_Nonsense_Mutation_p.R253*|MADD_ENST00000395336.3_Nonsense_Mutation_p.R253*|MADD_ENST00000311027.5_Nonsense_Mutation_p.R253*|MADD_ENST00000406482.1_Nonsense_Mutation_p.R253*	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	253	DENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CTGGATCTATCGATTGCTGCG	0.562													41	54					0	0	1	0	0	T	47297547	C	T	47297547	4	4	48	1	0	0	0	0	0	1	0	0	9197	876	31	1	767	1	MADD	11	47297547	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	375701	47297547	87708969	2602	6996										
MYBPC3	4607	broad.mit.edu	37	chr11	47364690	47364690	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggcaccgatggactcaaaGatgtacctgggtgggggccg	16	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:47364690G>T	ENST00000399249.2	-	14	1287	c.1233C>A	c.(1231-1233)atC>atA	p.I411I	MYBPC3_ENST00000545968.1_Silent_p.I411I|MYBPC3_ENST00000256993.4_Silent_p.I410I			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	410	Ig-like C2-type 2.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		TGGACTCAAAGATGTACCTGG	0.642													8	17					0.00307968	0.00320271	1	1	0	T	47364690	G	T	47364690	2	4	48	1	0	0	0	0	0	0	0	1	10060	932	33	2		2	MYBPC3	11	47364690	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	67143	47364690	87641826	2603	6997										
FNBP4	23360	broad.mit.edu	37	chr11	47767735	47767735	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatattgtccaacataattTcctgtggctttactattgtt	5	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:47767735T>A	ENST00000263773.5	-	7	1130	c.1118A>T	c.(1117-1119)gAa>gTa	p.E373V	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	373										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						CAACATAATTTCCTGTGGCTT	0.388													44	96					0	0	1	0	0	A	47767735	T	A	47767735	3	1	48	1	0	0	0	0	1	0	0	0	5999	1783	62	4	1979	4	FNBP4	11	47767735	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	403045	47767735	87238781	2604	6998										
OR4A47	403253	broad.mit.edu	37	chr11	48510546	48510546	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgctggcttatcatttataGatatcatttattcttcatcc	4	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:48510546G>T	ENST00000446524.1	+	1	278	c.202G>T	c.(202-204)Gat>Tat	p.D68Y		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						ATCATTTATAGATATCATTTA	0.423													20	30					8.34094e-07	9.42356e-07	1	1	0	T	48510546	G	T	48510546	3	4	48	1	0	0	0	0	1	0	0	0	11089	942	33	2	204	2	OR4A47	11	48510546	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	742811	48510546	86495970	2605	6999										
OR4A16	81327	broad.mit.edu	37	chr11	55111641	55111641	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacatatttattcctagttCtaaggcaacaaataggcggt	8	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55111641C>A	ENST00000314721.2	+	1	1015	c.965C>A	c.(964-966)tCt>tAt	p.S322Y		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	322					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATTCCTAGTTCTAAGGCAACA	0.338													6	13					3.59834e-05	3.93264e-05	1	1	0	A	55111641	C	A	55111641	3	1	48	1	0	0	0	0	1	0	0	0	11088	913	32	2	967	2	OR4A16	11	55111641	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6601095	55111641	79894875	2606	7000										
OR4C16	219428	broad.mit.edu	37	chr11	55339799	55339799	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttccttttctacttatccTtatctgatacttgcctctct	2	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55339799T>G	ENST00000314634.3	+	1	196	c.196T>G	c.(196-198)Tta>Gta	p.L66V		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				CTACTTATCCTTATCTGATAC	0.413													11	115					0	0	1	0	0	G	55339799	T	G	55339799	3	3	48	1	0	0	0	0	1	0	0	0	11096	1606	56	4	198	4	OR4C16	11	55339799	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	228158	55339799	79666717	2607	7001										
OR4C6	219432	broad.mit.edu	37	chr11	55433247	55433247	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttagttaccctcaacagtgGgatgatgtgtgtggccatct	11	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55433247G>A	ENST00000314259.3	+	1	634	c.605G>A	c.(604-606)gGg>gAg	p.G202E		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						CTCAACAGTGGGATGATGTGT	0.468													37	64					0	0	1	0	0	A	55433247	G	A	55433247	3	1	48	1	0	0	0	0	1	0	0	0	11099	1232	43	3	607	3	OR4C6	11	55433247	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	93448	55433247	79573269	2608	7002										
OR5D13	390142	broad.mit.edu	37	chr11	55541030	55541030	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttgttcgtctacacagtCactgtagtggggaacttggg	12	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55541030C>T	ENST00000361760.1	+	1	117	c.117C>T	c.(115-117)gtC>gtT	p.V39V		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TCTACACAGTCACTGTAGTGG	0.403													38	66					0	0	1	0	0	T	55541030	C	T	55541030	2	4	48	1	0	0	0	0	0	0	0	1	11200	813	29	3		3	OR5D13	11	55541030	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	107783	55541030	79465486	2609	7003										
OR5D14	219436	broad.mit.edu	37	chr11	55563549	55563549	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggttaaacttctctggacCtaatgtaatcaaccacttct	5	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55563549C>A	ENST00000335605.1	+	1	518	c.518C>A	c.(517-519)cCt>cAt	p.P173H		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TTCTCTGGACCTAATGTAATC	0.507													51	109					1.07234e-20	1.47176e-20	1	1	0	A	55563549	C	A	55563549	3	1	48	1	0	0	0	0	1	0	0	0	11201	681	24	5	520	5	OR5D14	11	55563549	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22519	55563549	79442967	2610	7004										
OR5D14	219436	broad.mit.edu	37	chr11	55563587	55563587	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttttgtgagtatactgctCtcatctctgtgtctggctct	8	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55563587C>T	ENST00000335605.1	+	1	556	c.556C>T	c.(556-558)Ctc>Ttc	p.L186F		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				GTATACTGCTCTCATCTCTGT	0.468													60	92					0	0	1	0	0	T	55563587	C	T	55563587	3	4	48	1	0	0	0	0	1	0	0	0	11201	913	32	3	558	3	OR5D14	11	55563587	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	38	55563587	79442929	2611	7005										
OR5L1	219437	broad.mit.edu	37	chr11	55579501	55579501	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctacctcctgtcttaagtCttgcttgctctgatatcact	5	12	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55579501C>A	ENST00000333973.2	+	1	648	c.559C>A	c.(559-561)Ctt>Att	p.L187I		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGTCTTAAGTCTTGCTTGCTC	0.433													5	183					0.014758	0.015099	1	1	0	A	55579501	C	A	55579501	3	1	48	1	0	0	0	0	1	0	0	0	11216	913	32	2	561	2	OR5L1	11	55579501	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15914	55579501	79427015	2612	7006										
OR5D18	219438	broad.mit.edu	37	chr11	55587551	55587551	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgctgctggttgtgggatCctatgcctggggagtctcat	15	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55587551C>A	ENST00000333976.4	+	1	466	c.446C>A	c.(445-447)tCc>tAc	p.S149Y		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GTTGTGGGATCCTATGCCTGG	0.473													58	113					7.10663e-31	1.01603e-30	1	1	0	A	55587551	C	A	55587551	3	1	48	1	0	0	0	0	1	0	0	0	11203	855	30	2	448	2	OR5D18	11	55587551	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8050	55587551	79418965	2613	7007										
OR5W2	390148	broad.mit.edu	37	chr11	55681139	55681139	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttccttaaaataaaattTtatttttcagttttttcagg	3	4	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55681139T>G	ENST00000344514.1	-	1	919	c.920A>C	c.(919-921)aAa>aCa	p.K307T		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						aaataaaattttatttttCAG	0.303													8	19					0	0	1	0	0	G	55681139	T	G	55681139	3	3	48	1	0	0	0	0	1	0	0	0	11231	1841	64	4	14	4	OR5W2	11	55681139	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	93588	55681139	79325377	2614	7008										
OR10AG1	282770	broad.mit.edu	37	chr11	55735436	55735436	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attggcgggatgtcacaaaaGaaatgattaattgtgttagt	11	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55735436G>T	ENST00000312345.2	-	1	554	c.504C>A	c.(502-504)ttC>ttA	p.F168L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					TGTCACAAAAGAAATGATTAA	0.403													11	31					5.16669e-11	6.39918e-11	1	1	0	T	55735436	G	T	55735436	3	4	48	1	0	0	0	0	1	0	0	0	10944	933	33	2	404	2	OR10AG1	11	55735436	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	54297	55735436	79271080	2615	7009										
OR10AG1	282770	broad.mit.edu	37	chr11	55735728	55735728	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaaatgtccatgagcattCttgggataatgattgttaca	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55735728C>A	ENST00000312345.2	-	1	262	c.212G>T	c.(211-213)aGa>aTa	p.R71I		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					CATGAGCATTCTTGGGATAAT	0.368													27	57					1.66031e-10	2.0393e-10	1	1	0	A	55735728	C	A	55735728	3	1	48	1	0	0	0	0	1	0	0	0	10944	913	32	2	696	2	OR10AG1	11	55735728	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	292	55735728	79270788	2616	7010										
OR5F1	338674	broad.mit.edu	37	chr11	55761503	55761503	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattcacaccagccaaaataGaacttatgctttctttcagg	5	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55761503G>T	ENST00000278409.1	-	1	598	c.599C>A	c.(598-600)tCt>tAt	p.S200Y		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AGCCAAAATAGAACTTATGCT	0.453													28	64					9.80776e-20	1.33792e-19	1	1	0	T	55761503	G	T	55761503	3	4	48	1	0	0	0	0	1	0	0	0	11204	942	33	2	348	2	OR5F1	11	55761503	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25775	55761503	79245013	2617	7011										
OR8I2	120586	broad.mit.edu	37	chr11	55861062	55861062	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaatcggagatccatctcCtttgttggctgctttgttca	8	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55861062C>A	ENST00000302124.2	+	1	310	c.279C>A	c.(277-279)tcC>tcA	p.S93S	OR8I2_ENST00000560768.1_Silent_p.S93S			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					GATCCATCTCCTTTGTTGGCT	0.388													53	67					9.86064e-34	1.41589e-33	1	1	0	A	55861062	C	A	55861062	2	1	48	1	0	0	0	0	0	0	0	1	11286	668	24	5		5	OR8I2	11	55861062	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	99559	55861062	79145454	2618	7012										
OR8K5	219453	broad.mit.edu	37	chr11	55926970	55926970	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttactaaagtgtaaaacacaGaagccattttatcagtatca	5	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:55926970G>T	ENST00000313447.1	-	1	823	c.824C>A	c.(823-825)tCt>tAt	p.S275Y		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GTAAAACACAGAAGCCATTTT	0.393													13	22					5.50884e-06	6.10489e-06	1	1	0	T	55926970	G	T	55926970	3	4	48	1	0	0	0	0	1	0	0	0	11291	942	33	2	102	2	OR8K5	11	55926970	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65908	55926970	79079546	2619	7013										
OR5T3	390154	broad.mit.edu	37	chr11	56020105	56020105	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggaactacagaatgttttCtcttggctgcaatggcttat	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56020105C>T	ENST00000303059.3	+	1	430	c.430C>T	c.(430-432)Ctc>Ttc	p.L144F		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L144I(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					AGAATGTTTTCTCTTGGCTGC	0.403													43	91					0	0	1	0	0	T	56020105	C	T	56020105	3	4	48	1	0	0	0	0	1	0	0	0	11229	913	32	3	432	3	OR5T3	11	56020105	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93135	56020105	78986411	2620	7014										
OR5T3	390154	broad.mit.edu	37	chr11	56020296	56020296	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaatgaaattaggcatgtCttttgtgatatgcctcctct	7	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56020296C>A	ENST00000303059.3	+	1	621	c.621C>A	c.(619-621)gtC>gtA	p.V207V		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TTAGGCATGTCTTTTGTGATA	0.408													70	122					1.26778e-28	1.80291e-28	1	1	0	A	56020296	C	A	56020296	2	1	48	1	0	0	0	0	0	0	0	1	11229	900	32	2		2	OR5T3	11	56020296	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	191	56020296	78986220	2621	7015										
OR5T1	390155	broad.mit.edu	37	chr11	56043431	56043431	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaaataaatctatttcatTtcttggatgtgcaacacaga	5	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56043431T>G	ENST00000313033.2	+	1	403	c.317T>G	c.(316-318)tTt>tGt	p.F106C		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TCTATTTCATTTCTTGGATGT	0.368													55	53					0	0	1	0	0	G	56043431	T	G	56043431	3	3	48	1	0	0	0	0	1	0	0	0	11227	1841	64	4	319	4	OR5T1	11	56043431	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23135	56043431	78963085	2622	7016										
OR5R1	219479	broad.mit.edu	37	chr11	56185045	56185045	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatccttaggatagcggcaaTaataaagatgtaggaggtga	13	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56185045T>C	ENST00000312253.1	-	1	663	c.664A>G	c.(664-666)Att>Gtt	p.I222V		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					ATAGCGGCAATAATAAAGATG	0.453													33	51					0	0	1	0	0	C	56185045	T	C	56185045	3	2	48	1	0	0	0	0	1	0	0	0	11226	1406	49	4	312	4	OR5R1	11	56185045	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	141614	56185045	78821471	2623	7017										
OR5M8	219484	broad.mit.edu	37	chr11	56258050	56258050	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccattttaccctgttcaacaGattcctttgaggggggtctg	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56258050G>T	ENST00000327216.2	-	1	821	c.797C>A	c.(796-798)tCt>tAt	p.S266Y		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S266C(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					CTGTTCAACAGATTCCTTTGA	0.378													6	41					0.0381472	0.0387537	1	1	0	T	56258050	G	T	56258050	3	4	48	1	0	0	0	0	1	0	0	0	11222	942	33	2	142	2	OR5M8	11	56258050	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	73005	56258050	78748466	2624	7018										
OR5AP2	338675	broad.mit.edu	37	chr11	56409495	56409495	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaaattctcccagacacgaGaactgggtagagcagggggt	14	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56409495G>A	ENST00000544374.1	-	1	452	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	OR5AP2_ENST00000302981.1_Missense_Mutation_p.L141F			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						CCAGACACGAGAACTGGGTAG	0.488													18	42					0	0	1	0	0	A	56409495	G	A	56409495	3	1	48	1	0	0	0	0	1	0	0	0	11190	942	33	3	533	3	OR5AP2	11	56409495	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	151445	56409495	78597021	2625	7019										
LRRC55	219527	broad.mit.edu	37	chr11	56949434	56949434	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccttcctgtgtcacagactCtcgattccatggacacagtc	8	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:56949434C>A	ENST00000497933.1	+	1	214	c.67C>A	c.(67-69)Ctc>Atc	p.L23I		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	0						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						GTCACAGACTCTCGATTCCAT	0.602													21	31					1.01871e-10	1.25646e-10	1	1	0	A	56949434	C	A	56949434	3	1	48	1	0	0	0	0	1	0	0	0	9055	913	32	2	69	2	LRRC55	11	56949434	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	539939	56949434	78057082	2626	7020										
APLNR	187	broad.mit.edu	37	chr11	57003380	57003380	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgtaggggatggatttctCgtgcatctgttctccaccct	11	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57003380C>T	ENST00000606794.1	-	1	1295	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	367						integral to plasma membrane	G-protein coupled receptor activity	p.E367K(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						ATGGATTTCTCGTGCATCTGT	0.647													21	51					0	0	1	0	0	T	57003380	C	T	57003380	3	4	48	1	0	0	0	0	1	0	0	0	774	893	31	1	47	1	APLNR	11	57003380	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53946	57003380	78003136	2627	7021										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57077055	57077055	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttgccagctgctctggtCtctctgcccgagtgccccat	10	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57077055C>A	ENST00000532437.1	-	5	3441	c.3130G>T	c.(3130-3132)Gac>Tac	p.D1044Y	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.D1044Y			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1044	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGCTCTGGTCTCTCTGCCCG	0.652													43	69					3.05275e-18	4.13032e-18	1	1	0	A	57077055	C	A	57077055	3	1	48	1	0	0	0	0	1	0	0	0	16379	913	32	2	2083	2	TNKS1BP1	11	57077055	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	73675	57077055	77929461	2628	7022										
TMX2	51075	broad.mit.edu	37	chr11	57505465	57505465	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttcttccgcttggatattCgcatgggcctactttacatc	7	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57505465C>T	ENST00000278422.4	+	3	343	c.331C>T	c.(331-333)Cgc>Tgc	p.R111C	TMX2-CTNND1_ENST00000528395.1_Intron|TMX2_ENST00000378312.4_Intron	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	111					cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						CTTGGATATTCGCATGGGCCT	0.393													40	61					0	0	1	0	0	T	57505465	C	T	57505465	3	4	48	1	0	0	0	0	1	0	0	0	16326	884	31	1	341	1	TMX2	11	57505465	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	428410	57505465	77501051	2629	7023										
TMX2	51075	broad.mit.edu	37	chr11	57506209	57506209	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggtctaatgactgccaatCatttgcccctatctatgctg	7	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57506209C>A	ENST00000278422.4	+	5	527	c.515C>A	c.(514-516)tCa>tAa	p.S172*	TMX2-CTNND1_ENST00000528395.1_Intron|TMX2_ENST00000378312.4_Nonsense_Mutation_p.S134*	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	172	Thioredoxin.				cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						GACTGCCAATCATTTGCCCCT	0.483													48	96					2.43468e-25	3.42684e-25	1	1	0	A	57506209	C	A	57506209	4	1	48	1	0	0	0	0	0	1	0	0	16326	838	29	2	533	2	TMX2	11	57506209	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	744	57506209	77500307	2630	7024										
CTNND1	1500	broad.mit.edu	37	chr11	57573508	57573508	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggggccaagaagggcaaagGtgagtcttggttcctgtttc	15	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57573508G>A	ENST00000524630.1	+	10	2389		c.e10+1		CTNND1_ENST00000525902.1_Splice_Site|CTNND1_ENST00000360682.6_Splice_Site|CTNND1_ENST00000531014.1_Splice_Site|CTNND1_ENST00000526938.1_Splice_Site|CTNND1_ENST00000428599.2_Splice_Site|CTNND1_ENST00000533667.1_Splice_Site|CTNND1_ENST00000528232.1_Splice_Site|CTNND1_ENST00000426142.2_Splice_Site|CTNND1_ENST00000529986.1_Splice_Site|CTNND1_ENST00000530094.1_Splice_Site|CTNND1_ENST00000361796.4_Splice_Site|CTNND1_ENST00000532787.1_Splice_Site|CTNND1_ENST00000529919.1_Splice_Site|CTNND1_ENST00000399050.4_Splice_Site|CTNND1_ENST00000532844.1_Splice_Site|CTNND1_ENST00000526357.1_Splice_Site|CTNND1_ENST00000399039.4_Splice_Site|CTNND1_ENST00000532463.1_Splice_Site|CTNND1_ENST00000530748.1_Splice_Site|CTNND1_ENST00000529873.1_Splice_Site|CTNND1_ENST00000532649.1_Splice_Site|CTNND1_ENST00000358694.6_Splice_Site|CTNND1_ENST00000527467.1_Splice_Site|CTNND1_ENST00000529526.1_Splice_Site|CTNND1_ENST00000361391.6_Splice_Site|CTNND1_ENST00000415361.2_Splice_Site|CTNND1_ENST00000526772.1_Splice_Site|CTNND1_ENST00000361332.4_Splice_Site|CTNND1_ENST00000532245.1_Splice_Site|CTNND1_ENST00000528621.1_Splice_Site|CTNND1_ENST00000534579.1_Splice_Site			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				AAGGGCAAAGGTGAGTCTTGG	0.483													5	11					0	0	1	0	0	A	57573508	G	A	57573508	5	1	48	1	0	0	0	0	0	0	1	0	4043	1275	44	3	1907	3	CTNND1	11	57573508	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	67299	57573508	77433008	2631	7025										
OR1S2	219958	broad.mit.edu	37	chr11	57971122	57971122	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggtcacagaagagcaattGaatgagcagaagggtgtgtg	16	4	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57971122G>T	ENST00000302592.6	-	1	531	c.532C>A	c.(532-534)Caa>Aaa	p.Q178K		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				AAGAGCAATTGAATGAGCAGA	0.463													20	235					2.48779e-11	3.09215e-11	1	1	0	T	57971122	G	T	57971122	3	4	48	1	0	0	0	0	1	0	0	0	11020	1299	45	2	448	2	OR1S2	11	57971122	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	397614	57971122	77035394	2632	7026										
OR1S2	219958	broad.mit.edu	37	chr11	57971527	57971527	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatacatactcaggaaaaGcacaaagaggaggttttgat	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57971527G>T	ENST00000302592.6	-	1	126	c.127C>A	c.(127-129)Ctt>Att	p.L43I		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				CTCAGGAAAAGCACAAAGAGG	0.453													44	76					2.2871e-25	3.22072e-25	1	1	0	T	57971527	G	T	57971527	3	4	48	1	0	0	0	0	1	0	0	0	11020	971	34	5	853	5	OR1S2	11	57971527	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	405	57971527	77034989	2633	7027										
OR1S1	219959	broad.mit.edu	37	chr11	57982521	57982521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgaatattcaaaccaagaGtcaatccatctcttatgaga	7	8	3	3	rs148202922		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57982521G>A	ENST00000309433.6	+	1	305	c.305G>A	c.(304-306)aGt>aAt	p.S102N		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				CAAACCAAGAGTCAATCCATC	0.428													65	105					0	0	1	0	0	A	57982521	G	A	57982521	3	1	48	1	0	0	0	0	1	0	0	0	11019	1029	36	3	307	3	OR1S1	11	57982521	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10994	57982521	77023995	2634	7028										
OR1S1	219959	broad.mit.edu	37	chr11	57982748	57982748	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacacacccttctgctcattCaattgctcttctgtaaccac	3	16	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:57982748C>A	ENST00000309433.6	+	1	532	c.532C>A	c.(532-534)Caa>Aaa	p.Q178K		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TCTGCTCATTCAATTGCTCTT	0.448													27	63					7.63505e-26	1.07707e-25	1	1	0	A	57982748	C	A	57982748	3	1	48	1	0	0	0	0	1	0	0	0	11019	827	29	2	534	2	OR1S1	11	57982748	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	227	57982748	77023768	2635	7029										
OR5B3	441608	broad.mit.edu	37	chr11	58170438	58170438	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaggcattcaggaaaccacAgaggtaggagcctatggcca	14	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:58170438A>C	ENST00000309403.2	-	1	444	c.445T>G	c.(445-447)Tgt>Ggt	p.C149G		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGGAAACCACAGAGGTAGGAG	0.478													41	72					0	0	1	0	0	C	58170438	A	C	58170438	3	2	48	1	0	0	0	0	1	0	0	0	11198	188	7	4	501	4	OR5B3	11	58170438	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	187690	58170438	76836078	2636	7030										
OR5B3	441608	broad.mit.edu	37	chr11	58170849	58170849	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcattggttagtcctagaaGaatgaattgtgttacttctg	10	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:58170849G>T	ENST00000309403.2	-	1	33	c.34C>A	c.(34-36)Ctt>Att	p.L12I		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGTCCTAGAAGAATGAATTGT	0.388													18	74					1.56452e-12	1.97515e-12	1	1	0	T	58170849	G	T	58170849	3	4	48	1	0	0	0	0	1	0	0	0	11198	942	33	2	912	2	OR5B3	11	58170849	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	411	58170849	76835667	2637	7031										
ZFP91	80829	broad.mit.edu	37	chr11	58384868	58384868	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctggctgccaatgcaggcGccctcatcaccagcacagat	9	16	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:58384868G>A	ENST00000316059.6	+	11	1573	c.1402G>A	c.(1402-1404)Gcc>Acc	p.A468T	ZFP91-CNTF_ENST00000389919.4_Missense_Mutation_p.A468T	NM_001197051.1|NM_053023.4	NP_001183980.1|NP_444251.1	Q96JP5	ZFP91_HUMAN	ZFP91 zinc finger protein	468					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CAATGCAGGCGCCCTCATCAC	0.537													20	25					0	0	1	0	0	A	58384868	G	A	58384868	3	1	48	1	0	0	0	0	1	0	0	0	17712	1087	38	1	1444	1	ZFP91	11	58384868	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	214019	58384868	76621648	2638	7032										
GLYAT	10249	broad.mit.edu	37	chr11	58478199	58478199	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaggacttaatggctgcaaGattttgtatagcctcattca	9	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:58478199G>A	ENST00000344743.3	-	5	493	c.352C>T	c.(352-354)Ctt>Ttt	p.L118F	GLYAT_ENST00000529732.1_Missense_Mutation_p.L118F|GLYAT_ENST00000278400.3_Missense_Mutation_p.L118F	NM_201648.2	NP_964011.2	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase	118					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity			NS(1)|autonomic_ganglia(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	ATGGCTGCAAGATTTTGTATA	0.408													35	63					0	0	1	0	0	A	58478199	G	A	58478199	3	1	48	1	0	0	0	0	1	0	0	0	6520	942	33	3	550	3	GLYAT	11	58478199	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	93331	58478199	76528317	2639	7033										
DTX4	23220	broad.mit.edu	37	chr11	58949740	58949740	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacagcacaggcaccattcGaggcccactgaagaccgccc	11	16	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:58949740G>A	ENST00000227451.3	+	2	844	c.740G>A	c.(739-741)cGa>cAa	p.R247Q	DTX4_ENST00000532982.1_Missense_Mutation_p.R141Q	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	247					Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				GGCACCATTCGAGGCCCACTG	0.652													14	31					0	0	1	0	0	A	58949740	G	A	58949740	3	1	48	1	0	0	0	0	1	0	0	0	4823	1058	37	1	746	1	DTX4	11	58949740	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	471541	58949740	76056776	2640	7034										
PATL1	219988	broad.mit.edu	37	chr11	59421459	59421459	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcggatgagtacttaccttCtattctgttgctgtctctga	8	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:59421459C>A	ENST00000300146.9	-	9	1202	c.1118G>T	c.(1117-1119)aGa>aTa	p.R373I		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	373	Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						TACTTACCTTCTATTCTGTTG	0.388													32	45					9.65021e-13	1.22324e-12	1	1	0	A	59421459	C	A	59421459	3	1	48	1	0	0	0	0	1	0	0	0	11521	913	32	2	1238	2	PATL1	11	59421459	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	471719	59421459	75585057	2641	7035										
OR10V1	390201	broad.mit.edu	37	chr11	59480843	59480843	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagattaaaatggtgagtGgcagtgacaacaggaacccc	13	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:59480843G>T	ENST00000307552.2	-	1	494	c.476C>A	c.(475-477)cCa>cAa	p.P159Q		NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						AATGGTGAGTGGCAGTGACAA	0.532													5	53					1	1	1	1	0	T	59480843	G	T	59480843	3	4	48	1	0	0	0	0	1	0	0	0	10967	1348	47	5	457	5	OR10V1	11	59480843	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	59384	59480843	75525673	2642	7036										
TCN1	6947	broad.mit.edu	37	chr11	59620703	59620703	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtggttcgcctccactcaGaagttcccagtaggttctgt	10	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:59620703G>A	ENST00000257264.3	-	8	1317	c.1213C>T	c.(1213-1215)Ctg>Ttg	p.L405L		NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	405					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCTCCACTCAGAAGTTCCCAG	0.522													74	133					0	0	1	0	0	A	59620703	G	A	59620703	2	1	48	1	0	0	0	0	0	0	0	1	15765	933	33	3		3	TCN1	11	59620703	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	139860	59620703	75385813	2643	7037										
PLAC1L	0	broad.mit.edu	37	chr11	59811081	59811081	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacatacatatgtatatgaGtttatatatcttgttcgtga	6	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:59811081G>A	ENST00000278855.2	+	2	389	c.204G>A	c.(202-204)gaG>gaA	p.E68E	PLAC1L_ENST00000532905.1_Silent_p.E37E	NM_173801.3	NP_776162.2	Q86WS3	PLACL_HUMAN		68						extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						ATGTATATGAGTTTATATATC	0.368													6	31					0	0	1	0	0	A	59811081	G	A	59811081	2	1	48	1	0	0	0	0	0	0	0	1	12060	1020	36	3		3	PLAC1L	11	59811081	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	190378	59811081	75195435	2644	7038										
MS4A12	54860	broad.mit.edu	37	chr11	60268548	60268548	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatggttggattgatgcacAttggttttggaattgttttg	12	3	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:60268548A>G	ENST00000016913.4	+	3	364	c.307A>G	c.(307-309)Att>Gtt	p.I103V	MS4A12_ENST00000537076.1_Intron	NM_017716.2	NP_060186.2	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member 12	103						integral to membrane	receptor activity			breast(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)	17						ATTGATGCACATTGGTTTTGG	0.373													48	124					0	0	1	0	0	G	60268548	A	G	60268548	3	3	48	1	0	0	0	0	1	0	0	0	9904	217	8	4	313	4	MS4A12	11	60268548	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	457467	60268548	74737968	2645	7039										
MS4A15	219995	broad.mit.edu	37	chr11	60531322	60531322	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgtgccaacctccagggaTtatgcagtttgaggagccac	11	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:60531322T>G	ENST00000405633.3	+	2	195	c.116T>G	c.(115-117)aTt>aGt	p.I39S	MS4A15_ENST00000337911.4_Intron|MS4A15_ENST00000528170.1_Missense_Mutation_p.I39S	NM_001098835.1	NP_001092305.1	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member 15	39						integral to membrane	receptor activity			breast(1)|large_intestine(2)|lung(3)	6						CCTCCAGGGATTATGCAGTTT	0.602													51	95					0	0	1	0	0	G	60531322	T	G	60531322	3	3	48	1	0	0	0	0	1	0	0	0	9907	1493	52	4	118	4	MS4A15	11	60531322	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	262774	60531322	74475194	2646	7040										
ZP1	22917	broad.mit.edu	37	chr11	60635066	60635066	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagccacgacctggggttAccctgtggccctgctactgc	11	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:60635066A>G	ENST00000278853.5	+	1	32	c.32A>G	c.(31-33)tAc>tGc	p.Y11C		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	11					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						ACCTGGGGTTACCCTGTGGCC	0.672													11	29					0	0	1	0	0	G	60635066	A	G	60635066	3	3	48	1	0	0	0	0	1	0	0	0	18256	391	14	4	34	4	ZP1	11	60635066	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	103744	60635066	74371450	2647	7041										
VWCE	220001	broad.mit.edu	37	chr11	61026361	61026361	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcagaggaggccacctgGacactatctgggccccagag	14	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:61026361G>T	ENST00000335613.5	-	20	3040	c.2654C>A	c.(2653-2655)tCc>tAc	p.S885Y	VWCE_ENST00000535710.1_Missense_Mutation_p.S350Y	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	885						extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AGGCCACCTGGACACTATCTG	0.647													20	27					4.96729e-08	5.79844e-08	1	1	0	T	61026361	G	T	61026361	3	4	48	1	0	0	0	0	1	0	0	0	17304	1174	41	2	217	2	VWCE	11	61026361	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	391295	61026361	73980155	2648	7042										
DDB1	1642	broad.mit.edu	37	chr11	61081881	61081881	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggaggccacactgatgttCttggcctgaggctccttcca	11	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:61081881C>A	ENST00000301764.7	-	13	1885	c.1488G>T	c.(1486-1488)aaG>aaT	p.K496N	DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	496	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CACTGATGTTCTTGGCCTGAG	0.532								Nucleotide excision repair (NER)					13	176					5.50884e-06	6.10489e-06	1	1	0	A	61081881	C	A	61081881	3	1	48	1	0	0	0	0	1	0	0	0	4346	912	32	2	1994	2	DDB1	11	61081881	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	55520	61081881	73924635	2649	7043										
AHNAK	79026	broad.mit.edu	37	chr11	62288113	62288113	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaacttcaggcatagagatCttcggtgccttgaggtgtaa	11	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:62288113C>A	ENST00000378024.4	-	5	14050	c.13776G>T	c.(13774-13776)aaG>aaT	p.K4592N	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4592					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GCATAGAGATCTTCGGTGCCT	0.498													36	53					4.65686e-17	6.22576e-17	1	1	0	A	62288113	C	A	62288113	3	1	48	1	0	0	0	0	1	0	0	0	411	912	32	2	4016	2	AHNAK	11	62288113	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1206232	62288113	72718403	2650	7044										
AHNAK	79026	broad.mit.edu	37	chr11	62290081	62290081	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcatgctgatcttgggcatTtttatcttaggcatcttcag	10	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:62290081T>C	ENST00000378024.4	-	5	12082	c.11808A>G	c.(11806-11808)aaA>aaG	p.K3936K	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3936					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCTTGGGCATTTTTATCTTAG	0.507													137	212					0	0	1	0	0	C	62290081	T	C	62290081	2	2	48	1	0	0	0	0	0	0	0	1	411	1838	64	4		4	AHNAK	11	62290081	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1968	62290081	72716435	2651	7045										
AHNAK	79026	broad.mit.edu	37	chr11	62290790	62290790	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtccacctcagggccttttAgatcaccttccactttgggc	8	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:62290790A>C	ENST00000378024.4	-	5	11373	c.11099T>G	c.(11098-11100)cTa>cGa	p.L3700R	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3700					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGGGCCTTTTAGATCACCTTC	0.483													97	174					0	0	1	0	0	C	62290790	A	C	62290790	3	2	48	1	0	0	0	0	1	0	0	0	411	420	15	4	6693	4	AHNAK	11	62290790	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	709	62290790	72715726	2652	7046										
MTA2	9219	broad.mit.edu	37	chr11	62364120	62364120	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccacttacaaaatcctggcGaatatcattgaagtccttcc	5	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:62364120G>A	ENST00000278823.2	-	9	1260	c.871C>T	c.(871-873)Cgc>Tgc	p.R291C	MTA2_ENST00000524902.1_Missense_Mutation_p.R118C|MTA2_ENST00000527204.1_Missense_Mutation_p.R118C	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	291	SANT.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						AAATCCTGGCGAATATCATTG	0.542													31	53					0	0	1	0	0	A	62364120	G	A	62364120	3	1	48	1	0	0	0	0	1	0	0	0	9956	1058	37	1	1175	1	MTA2	11	62364120	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	73330	62364120	72642396	2653	7047										
EML3	256364	broad.mit.edu	37	chr11	62374545	62374545	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccggaaggaacacaaagcaAgggataaacttgggtttctt	11	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:62374545A>C	ENST00000394773.2	-	12	1696	c.1389T>G	c.(1387-1389)ccT>ccG	p.P463P	EML3_ENST00000278845.4_Silent_p.P464P|EML3_ENST00000438258.1_5'UTR|EML3_ENST00000531557.1_Silent_p.P246P|EML3_ENST00000494176.2_Silent_p.P435P|EML3_ENST00000529309.1_Silent_p.P463P	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	463						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						ACACAAAGCAAGGGATAAACT	0.527													25	58					0	0	1	0	0	C	62374545	A	C	62374545	2	2	48	1	0	0	0	0	0	0	0	1	5126	59	3	4		4	EML3	11	62374545	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	10425	62374545	72631971	2654	7048										
SLC22A25	387601	broad.mit.edu	37	chr11	62996981	62996981	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagtatatgaacccagcaGcgatgatcaagtatgaatgc	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:62996981G>A	ENST00000306494.6	-	1	143	c.144C>T	c.(142-144)cgC>cgT	p.R48R	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	48					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GAACCCAGCAGCGATGATCAA	0.463													42	55					0	0	1	0	0	A	62996981	G	A	62996981	2	1	48	1	0	0	0	0	0	0	0	1	14508	958	34	3		3	SLC22A25	11	62996981	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	622436	62996981	72009535	2655	7049										
HRASLS5	117245	broad.mit.edu	37	chr11	63235894	63235894	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagtgctcatagccaattCgaaaaatctcaatcaggtct	6	12	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:63235894C>T	ENST00000540857.1	-	4	521	c.389G>A	c.(388-390)cGa>cAa	p.R130Q	HRASLS5_ENST00000301790.4_Missense_Mutation_p.R140Q|HRASLS5_ENST00000539221.1_Missense_Mutation_p.R140Q	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201.1|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	140										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						ATAGCCAATTCGAAAAATCTC	0.423													4	90					0	0	1	0	0	T	63235894	C	T	63235894	3	4	48	1	0	0	0	0	1	0	0	0	7391	884	31	1	432	1	HRASLS5	11	63235894	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	238913	63235894	71770622	2656	7050										
NRXN2	9379	broad.mit.edu	37	chr11	64374680	64374680	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgggggctcagacataataCtccttgtctttgttcttctt	8	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:64374680C>A	ENST00000265459.6	-	23	5588	c.5127G>T	c.(5125-5127)gaG>gaT	p.E1709D	NRXN2_ENST00000377551.1_Missense_Mutation_p.E1709D|NRXN2_ENST00000301894.2_Missense_Mutation_p.E663D|NRXN2_ENST00000409571.1_Missense_Mutation_p.E1702D|NRXN2_ENST00000377559.3_Missense_Mutation_p.E1639D	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1709					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						AGACATAATACTCCTTGTCTT	0.662													11	25					0.010729	0.0110271	1	1	0	A	64374680	C	A	64374680	3	1	48	1	0	0	0	0	1	0	0	0	10713	564	20	5	15	5	NRXN2	11	64374680	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1138786	64374680	70631836	2657	7051										
PYGM	5837	broad.mit.edu	37	chr11	64527344	64527344	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acactgatttgctttcttttCtcttggtctgacaggggccg	10	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:64527344C>A	ENST00000164139.3	-	1	425	c.27G>T	c.(25-27)gaG>gaT	p.E9D	PYGM_ENST00000377432.3_Missense_Mutation_p.E9D	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	9					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GCTTTCTTTTCTCTTGGTCTG	0.597													41	90					4.67007e-22	6.4791e-22	1	1	0	A	64527344	C	A	64527344	3	1	48	1	0	0	0	0	1	0	0	0	12913	912	32	2	2581	2	PYGM	11	64527344	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	152664	64527344	70479172	2658	7052										
DPF2	5977	broad.mit.edu	37	chr11	65116351	65116351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttctgtgatgactgcgatCgtggctaccacatgtactgt	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:65116351C>T	ENST00000528416.1	+	10	1181	c.1048C>T	c.(1048-1050)Cgt>Tgt	p.R350C	DPF2_ENST00000252268.4_Missense_Mutation_p.R364C|DPF2_ENST00000415073.2_Missense_Mutation_p.R166C	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	350					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						TGACTGCGATCGTGGCTACCA	0.488													23	40					0	0	1	0	0	T	65116351	C	T	65116351	3	4	48	1	0	0	0	0	1	0	0	0	4744	884	31	1	1086	1	DPF2	11	65116351	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	589007	65116351	69890165	2659	7053										
PELI3	246330	broad.mit.edu	37	chr11	66239872	66239872	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtggtcagcacagcatctcGtatacactgtcccggagcca	10	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:66239872G>A	ENST00000349459.6	+	4	599	c.315G>A	c.(313-315)tcG>tcA	p.S105S	PELI3_ENST00000531856.1_Intron|PELI3_ENST00000524466.1_Silent_p.S129S|PELI3_ENST00000320740.7_Silent_p.S129S	NM_001098510.1	NP_001091980.1	Q8N2H9	PELI3_HUMAN	pellino E3 ubiquitin protein ligase family member 3	129						cytosol	protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	15						ACAGCATCTCGTATACACTGT	0.532													31	64					0	0	1	0	0	A	66239872	G	A	66239872	2	1	48	1	0	0	0	0	0	0	0	1	11769	1132	40	1		1	PELI3	11	66239872	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1123521	66239872	68766644	2660	7054										
DPP3	10072	broad.mit.edu	37	chr11	66259175	66259175	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctctcccccagttacatCgggttcatcgagagctaccg	8	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:66259175C>T	ENST00000532677.1	+	9	1394	c.993C>T	c.(991-993)atC>atT	p.I331I	DPP3_ENST00000360510.2_Silent_p.I312I|DPP3_ENST00000453114.1_Silent_p.I312I|DPP3_ENST00000541961.1_Silent_p.I312I|DPP3_ENST00000530165.1_Silent_p.I282I|DPP3_ENST00000531863.1_Silent_p.I332I	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	312					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						CCAGTTACATCGGGTTCATCG	0.622													65	128					0	0	1	0	0	T	66259175	C	T	66259175	2	4	48	1	0	0	0	0	0	0	0	1	4754	874	31	1		1	DPP3	11	66259175	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19303	66259175	68747341	2661	7055										
ACTN3	89	broad.mit.edu	37	chr11	66319048	66319048	+	RNA	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagatgcgcttccacaaaatCgccaacgttaacaaggccct	7	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:66319048C>A	ENST00000513398.1	+	0	409				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						TCCACAAAATCGCCAACGTTA	0.547													26	34					8.24728e-16	1.09065e-15	1	1	0	A	66319048	C	A	66319048	1	1	48	0	1	0	0	0	0	0	0	0	206	874	31	2		2	ACTN3	11	66319048	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	59873	66319048	68687468	2662	7056										
CTSF	8722	broad.mit.edu	37	chr11	66335859	66335859	+	Frame_Shift_Del	DEL	C	C	-													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagctccggggacggcggCccccaggcctgaaagctggc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:66335859delC	ENST00000310325.5	-	1	208	c.99delG	c.(97-99)ggfs	p.G33fs		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	33					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GGGACGGCGGCCCCCAGGCCT	0.781													2	4	---	---	---	---						-	66335859	C	-	66335859	7	5	48	1	0	1	0	1	0	0	0	0	4058	726	26	0	1407	0	CTSF	11	66335859	Frame_Shift_Del	DEL	C	TCGA-ND-A4WC-01A-21D-A28R-08	16811	66335859	68670657	2663	7057										
ADRBK1	156	broad.mit.edu	37	chr11	67049829	67049829	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccaagaagaagccccatGccagcgtgtgagtgcccccc	10	16	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:67049829G>A	ENST00000308595.5	+	12	1335	c.1045G>A	c.(1045-1047)Gcc>Acc	p.A349T	ADRBK1_ENST00000527176.1_Intron|ADRBK1_ENST00000526285.1_Missense_Mutation_p.A349T	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	349	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GAAGCCCCATGCCAGCGTGTG	0.652													39	54					0	0	1	0	0	A	67049829	G	A	67049829	3	1	48	1	0	0	0	0	1	0	0	0	342	1319	46	3	1091	3	ADRBK1	11	67049829	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	713970	67049829	67956687	2664	7058										
GPR152	390212	broad.mit.edu	37	chr11	67219701	67219701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcctcggggaagaccagccaGggcacgctgaagagtgtggc	17	11	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:67219701G>A	ENST00000312457.2	-	1	499	c.495C>T	c.(493-495)ccC>ccT	p.P165P		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	165						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGACCAGCCAGGGCACGCTGA	0.677													14	96					0	0	1	0	0	A	67219701	G	A	67219701	2	1	48	1	0	0	0	0	0	0	0	1	6697	987	35	3		3	GPR152	11	67219701	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	169872	67219701	67786815	2665	7059										
TBX10	347853	broad.mit.edu	37	chr11	67400485	67400485	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagatgaaggacttgaagttCtcctgggcatagcgctcact	11	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:67400485C>T	ENST00000335385.3	-	5	726	c.639G>A	c.(637-639)gaG>gaA	p.E213E		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	213					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						ACTTGAAGTTCTCCTGGGCAT	0.572													82	140					0	0	1	0	0	T	67400485	C	T	67400485	2	4	48	1	0	0	0	0	0	0	0	1	15710	912	32	3		3	TBX10	11	67400485	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	180784	67400485	67606031	2666	7060										
SUV420H1	51111	broad.mit.edu	37	chr11	67926511	67926511	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtttctttggtaccctggaAttatttatatgagttagctt	8	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:67926511A>C	ENST00000304363.4	-	11	1655	c.1302T>G	c.(1300-1302)aaT>aaG	p.N434K		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						GTACCCTGGAATTATTTATAT	0.373													20	36					0	0	1	0	0	C	67926511	A	C	67926511	3	2	48	1	0	0	0	0	1	0	0	0	15469	98	4	4	1359	4	SUV420H1	11	67926511	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	526026	67926511	67080005	2667	7061										
LRP5	4041	broad.mit.edu	37	chr11	68171142	68171142	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccgacctgatggggctcaaAgctgtgaatgtggccaaggt	14	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:68171142A>C	ENST00000294304.7	+	8	1882	c.1776A>C	c.(1774-1776)aaA>aaC	p.K592N		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	592	Beta-propeller 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TGGGGCTCAAAGCTGTGAATG	0.627													7	69					0	0	1	0	0	C	68171142	A	C	68171142	3	2	48	1	0	0	0	0	1	0	0	0	9004	69	3	4	1806	4	LRP5	11	68171142	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	244631	68171142	66835374	2668	7062										
IGHMBP2	3508	broad.mit.edu	37	chr11	68696697	68696697	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgctgcccgagagctacttCgacgtggtggtcattgacga	13	10	1	2	rs137852670		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:68696697C>T	ENST00000255078.3	+	8	1218	c.1107C>T	c.(1105-1107)ttC>ttT	p.F369F		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	369	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AGAGCTACTTCGACGTGGTGG	0.642													46	76					0	0	1	0	0	T	68696697	C	T	68696697	2	4	48	1	0	0	0	0	0	0	0	1	7634	883	31	1		1	IGHMBP2	11	68696697	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	525555	68696697	66309819	2669	7063										
ANO1	55107	broad.mit.edu	37	chr11	69951871	69951871	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgataaggattcctttttcGacagcaaaacccggagcacg	9	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:69951871G>A	ENST00000355303.5	+	5	1029	c.724G>A	c.(724-726)Gac>Aac	p.D242N	ANO1_ENST00000530676.1_Missense_Mutation_p.D126N|ANO1_ENST00000398543.2_Missense_Mutation_p.D126N|ANO1_ENST00000538023.1_Missense_Mutation_p.D242N|ANO1_ENST00000316296.5_Missense_Mutation_p.D214N	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	242					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TTCCTTTTTCGACAGCAAAAC	0.488													18	28					0	0	1	0	0	A	69951871	G	A	69951871	3	1	48	1	0	0	0	0	1	0	0	0	689	1058	37	1	742	1	ANO1	11	69951871	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1255174	69951871	65054645	2670	7064										
PPFIA1	8500	broad.mit.edu	37	chr11	70170513	70170513	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgtgattttctaggagttCgcagcacttactaaagaact	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:70170513C>T	ENST00000253925.7	+	3	485	c.270C>T	c.(268-270)ttC>ttT	p.F90F	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.F90F	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	90					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TCTAGGAGTTCGCAGCACTTA	0.403													48	70					0	0	1	0	0	T	70170513	C	T	70170513	2	4	48	1	0	0	0	0	0	0	0	1	12353	883	31	1		1	PPFIA1	11	70170513	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	218642	70170513	64836003	2671	7065										
PPFIA1	8500	broad.mit.edu	37	chr11	70171616	70171616	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttattttcaggtgagagagcGattacgagtagcacttgaaa	11	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:70171616G>A	ENST00000253925.7	+	5	757	c.542G>A	c.(541-543)cGa>cAa	p.R181Q	CTA-797E19.2_ENST00000526017.1_RNA|AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.R181Q	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	181					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GTGAGAGAGCGATTACGAGTA	0.353													30	72					0	0	1	0	0	A	70171616	G	A	70171616	3	1	48	1	0	0	0	0	1	0	0	0	12353	1058	37	1	556	1	PPFIA1	11	70171616	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1103	70171616	64834900	2672	7066										
NADSYN1	55191	broad.mit.edu	37	chr11	71174492	71174492	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcaggcctgtaatgcaccGaaacgtccgctacaactgca	9	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:71174492G>A	ENST00000319023.2	+	4	466	c.278G>A	c.(277-279)cGa>cAa	p.R93Q		NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	93	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTAATGCACCGAAACGTCCGC	0.602													7	36					0	0	1	0	0	A	71174492	G	A	71174492	3	1	48	1	0	0	0	0	1	0	0	0	10185	1058	37	1	292	1	NADSYN1	11	71174492	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1002876	71174492	63832024	2673	7067										
PDE2A	5138	broad.mit.edu	37	chr11	72289284	72289284	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagctcactcacttgtagaTgggcattgcaatgtgctcca	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:72289284T>G	ENST00000334456.5	-	30	2853	c.2608A>C	c.(2608-2610)Atc>Ctc	p.I870L	PDE2A_ENST00000418754.2_Missense_Mutation_p.I755L|PDE2A_ENST00000444035.2_Missense_Mutation_p.I861L|PDE2A_ENST00000544570.1_Missense_Mutation_p.I863L|PDE2A_ENST00000376450.3_Missense_Mutation_p.I614L|PDE2A_ENST00000540345.1_Missense_Mutation_p.I861L	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	870	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CACTTGTAGATGGGCATTGCA	0.557													19	50					0	0	1	0	0	G	72289284	T	G	72289284	3	3	48	1	0	0	0	0	1	0	0	0	11682	1464	51	4	225	4	PDE2A	11	72289284	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1114792	72289284	62717232	2674	7068										
ARAP1	116985	broad.mit.edu	37	chr11	72418358	72418358	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaggtagacagggcctcagCgatggctccctgcatggcct	14	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:72418358C>T	ENST00000359373.5	-	12	2436	c.1585G>A	c.(1585-1587)Gct>Act	p.A529T	ARAP1_ENST00000393605.3_Missense_Mutation_p.A289T|ARAP1_ENST00000429686.1_Missense_Mutation_p.A284T|ARAP1_ENST00000455638.2_Missense_Mutation_p.A529T|ARAP1_ENST00000393609.3_Missense_Mutation_p.A529T|ARAP1_ENST00000334211.8_Missense_Mutation_p.A284T|ARAP1_ENST00000426523.1_Missense_Mutation_p.A284T			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	529	PH 2.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						AGGGCCTCAGCGATGGCTCCC	0.632													21	31					0	0	1	0	0	T	72418358	C	T	72418358	3	4	48	1	0	0	0	0	1	0	0	0	835	768	27	1	2863	1	ARAP1	11	72418358	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	129074	72418358	62588158	2675	7069										
ATG16L2	89849	broad.mit.edu	37	chr11	72537800	72537800	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgccaaattcaagctaaCgaggcaccaggcagtgactg	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:72537800C>T	ENST00000321297.5	+	13	1436	c.1298C>T	c.(1297-1299)aCg>aTg	p.T433M	ATG16L2_ENST00000534905.1_Intron	NM_033388.1	NP_203746.1	Q8NAA4	A16L2_HUMAN	autophagy related 16-like 2 (S. cerevisiae)	433					autophagy|protein transport	cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	14			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			TTCAAGCTAACGAGGCACCAG	0.612													37	62					0	0	1	0	0	T	72537800	C	T	72537800	3	4	48	1	0	0	0	0	1	0	0	0	1091	536	19	1	1348	1	ATG16L2	11	72537800	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	119442	72537800	62468716	2676	7070										
UCP3	7352	broad.mit.edu	37	chr11	73717235	73717235	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtccgcgcctttgggggtgtAcacctgcttgacggagtcat	14	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:73717235A>G	ENST00000314032.4	-	3	868	c.316T>C	c.(316-318)Tac>Cac	p.Y106H	UCP3_ENST00000426995.2_Missense_Mutation_p.Y106H|UCP3_ENST00000348534.4_Missense_Mutation_p.Y106H	NM_003356.3	NP_003347.1	P55916	UCP3_HUMAN	uncoupling protein 3 (mitochondrial, proton carrier)	106					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	12	Breast(11;2.08e-05)					TTGGGGGTGTACACCTGCTTG	0.612													6	31					0	0	1	0	0	G	73717235	A	G	73717235	3	3	48	1	0	0	0	0	1	0	0	0	16991	391	14	4	646	4	UCP3	11	73717235	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1179435	73717235	61289281	2677	7071										
C2CD3	26005	broad.mit.edu	37	chr11	73844488	73844488	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtgttgatgctctaagaGaatcttcattaataggagga	10	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:73844488G>T	ENST00000334126.7	-	6	1296	c.1070C>A	c.(1069-1071)tCt>tAt	p.S357Y	C2CD3_ENST00000539061.1_Missense_Mutation_p.S357Y|C2CD3_ENST00000313663.7_Missense_Mutation_p.S357Y			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	357						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TGCTCTAAGAGAATCTTCATT	0.383													5	26					0.014758	0.015099	1	1	0	T	73844488	G	T	73844488	3	4	48	1	0	0	0	0	1	0	0	0	2168	942	33	2	4925	2	C2CD3	11	73844488	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	127253	73844488	61162028	2678	7072										
CHRDL2	25884	broad.mit.edu	37	chr11	74421962	74421962	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatgggcactgaagatctCtccgtgttggtacatggtcc	11	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:74421962C>A	ENST00000376332.3	-	4	860	c.364G>T	c.(364-366)Gag>Tag	p.E122*	CHRDL2_ENST00000263671.5_Nonsense_Mutation_p.E122*|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	122	VWFC 2.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CTGAAGATCTCTCCGTGTTGG	0.612													10	16					0.00621372	0.0064192	1	1	0	A	74421962	C	A	74421962	4	1	48	1	0	0	0	0	0	1	0	0	3396	922	32	2	1027	2	CHRDL2	11	74421962	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	577474	74421962	60584554	2679	7073										
SLCO2B1	11309	broad.mit.edu	37	chr11	74880412	74880412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctttggcatctcctacatcGatgactttgcccacaacagc	6	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:74880412G>A	ENST00000289575.5	+	5	1038	c.643G>A	c.(643-645)Gat>Aat	p.D215N	SLCO2B1_ENST00000532236.1_Missense_Mutation_p.D99N|SLCO2B1_ENST00000428359.2_Missense_Mutation_p.D193N|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.D71N|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000454962.2_Intron	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	215				D -> V (in Ref. 6).	sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CTCCTACATCGATGACTTTGC	0.597													20	44					0	0	1	0	0	A	74880412	G	A	74880412	3	1	48	1	0	0	0	0	1	0	0	0	14781	1058	37	1	661	1	SLCO2B1	11	74880412	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	458450	74880412	60126104	2680	7074										
MOGAT2	80168	broad.mit.edu	37	chr11	75439940	75439940	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccagaatcggttgcagaaGatcatgggcatctccctccc	9	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:75439940G>T	ENST00000526712.1	+	4	1283	c.510G>T	c.(508-510)aaG>aaT	p.K170N	MOGAT2_ENST00000198801.5_Missense_Mutation_p.K252N			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	252					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					GGTTGCAGAAGATCATGGGCA	0.522													38	65					6.04917e-29	8.60473e-29	1	1	0	T	75439940	G	T	75439940	3	4	48	1	0	0	0	0	1	0	0	0	9743	933	33	2	774	2	MOGAT2	11	75439940	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	559528	75439940	59566576	2681	7075										
MYO7A	4647	broad.mit.edu	37	chr11	76910822	76910822	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctagaggggctccggaagaGatctaagtatgttgtggccc	14	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:76910822G>T	ENST00000409709.3	+	35	5083	c.4811G>T	c.(4810-4812)aGa>aTa	p.R1604I	MYO7A_ENST00000409619.2_Missense_Mutation_p.R1555I|MYO7A_ENST00000458637.2_Missense_Mutation_p.R1566I	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1604	SH3.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CTCCGGAAGAGATCTAAGTAT	0.577													6	20					8.12818e-05	8.79784e-05	1	1	0	T	76910822	G	T	76910822	3	4	48	1	0	0	0	0	1	0	0	0	10129	942	33	2	4979	2	MYO7A	11	76910822	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1470882	76910822	58095694	2682	7076										
GDPD4	220032	broad.mit.edu	37	chr11	76990353	76990353	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgagaagcattactcaccaAcagcaatgaagagtaggcag	10	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:76990353A>G	ENST00000315938.4	-	3	395	c.145T>C	c.(145-147)Ttg>Ctg	p.L49L	GDPD4_ENST00000527489.1_Intron|GDPD4_ENST00000376217.2_Silent_p.L49L	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	49					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						TTACTCACCAACAGCAATGAA	0.438													14	23					0	0	1	0	0	G	76990353	A	G	76990353	2	3	48	1	0	0	0	0	0	0	0	1	6367	40	2	4		4	GDPD4	11	76990353	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	79531	76990353	58016163	2683	7077										
INTS4	92105	broad.mit.edu	37	chr11	77612494	77612494	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagttcgtgctgttactataAgttgcaaagctttggcctgc	10	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:77612494A>C	ENST00000534064.1	-	18	2235	c.2201T>G	c.(2200-2202)cTt>cGt	p.L734R	AAMDC_ENST00000532481.1_Intron|INTS4_ENST00000535943.1_Missense_Mutation_p.L109R	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	734					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TGTTACTATAAGTTGCAAAGC	0.423													30	123					0	0	1	0	0	C	77612494	A	C	77612494	3	2	48	1	0	0	0	0	1	0	0	0	7823	72	3	4	714	4	INTS4	11	77612494	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	622141	77612494	57394022	2684	7078										
INTS4	92105	broad.mit.edu	37	chr11	77692505	77692505	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttttaaattgcaacttacTttcattctgcaggatgttga	7	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:77692505T>G	ENST00000534064.1	-	3	398	c.364_splice	c.e3+1	p.K122_splice	INTS4_ENST00000529807.1_Splice_Site_p.K122_splice	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	122					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TGCAACTTACTTTCATTCTGC	0.328													9	12					0	0	1	0	0	G	77692505	T	G	77692505	5	3	48	1	0	0	0	0	0	0	1	0	7823	1623	56	4	2611	4	INTS4	11	77692505	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	80011	77692505	57314011	2685	7079										
PRCP	5547	broad.mit.edu	37	chr11	82564263	82564263	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagagactctccatagtatcGatgttcagcaaacaccaaca	7	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:82564263G>A	ENST00000313010.3	-	3	561	c.367C>T	c.(367-369)Cga>Tga	p.R123*	PRCP_ENST00000535099.1_Nonsense_Mutation_p.R18*|PRCP_ENST00000393399.2_Nonsense_Mutation_p.R144*	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	123					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						CCATAGTATCGATGTTCAGCA	0.363													8	26					0	0	1	0	0	A	82564263	G	A	82564263	4	1	48	1	0	0	0	0	0	1	0	0	12500	1066	37	1	1151	1	PRCP	11	82564263	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4871758	82564263	52442253	2686	7080										
RAB30	27314	broad.mit.edu	37	chr11	82698747	82698747	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaggatcaaggcattggcGcttcggtagtaactctgggt	15	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:82698747G>A	ENST00000533486.1	-	5	527	c.243C>T	c.(241-243)agC>agT	p.S81S	RP11-659G9.3_ENST00000527550.1_RNA|RAB30_ENST00000527633.1_Silent_p.S81S|RAB30_ENST00000532548.1_Silent_p.S81S|RAB30_ENST00000525117.1_Silent_p.S53S|RAB30_ENST00000534141.1_Silent_p.S81S|RAB30_ENST00000260056.2_Silent_p.S81S	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	81					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						AGGCATTGGCGCTTCGGTAGT	0.483													11	78					0	0	1	0	0	A	82698747	G	A	82698747	2	1	48	1	0	0	0	0	0	0	0	1	12970	1078	38	1		1	RAB30	11	82698747	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	134484	82698747	52307769	2687	7081										
PCF11	51585	broad.mit.edu	37	chr11	82872456	82872456	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtatctcactgcctttactAaaaatctagttgcaacattt	4	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:82872456A>G	ENST00000298281.4	+	2	732	c.280A>G	c.(280-282)Aaa>Gaa	p.K94E		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	94	CID.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						TGCCTTTACTAAAAATCTAGT	0.313													7	17					0	0	1	0	0	G	82872456	A	G	82872456	3	3	48	1	0	0	0	0	1	0	0	0	11619	363	13	4	286	4	PCF11	11	82872456	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	173709	82872456	52134060	2688	7082										
PCF11	51585	broad.mit.edu	37	chr11	82878235	82878235	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagagctggtcaagcactaAaggaattttatcacctcgag	11	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:82878235A>C	ENST00000298281.4	+	6	2338	c.1886A>C	c.(1885-1887)aAa>aCa	p.K629T		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	629					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						TCAAGCACTAAAGGAATTTTA	0.408													46	74					0	0	1	0	0	C	82878235	A	C	82878235	3	2	48	1	0	0	0	0	1	0	0	0	11619	14	1	4	1908	4	PCF11	11	82878235	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5779	82878235	52128281	2689	7083										
ANKRD42	338699	broad.mit.edu	37	chr11	82909623	82909623	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgtggagccagcattaatgAacttgatgttctccataagt	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:82909623A>C	ENST00000393389.3	+	2	1093	c.161A>C	c.(160-162)gAa>gCa	p.E54A	ANKRD42_ENST00000533342.1_Missense_Mutation_p.E54A|ANKRD42_ENST00000526731.1_Missense_Mutation_p.E54A|ANKRD42_ENST00000393392.2_Intron|ANKRD42_ENST00000260047.6_Missense_Mutation_p.E54A|ANKRD42_ENST00000531895.1_Missense_Mutation_p.E54A|ANKRD42_ENST00000528722.1_5'UTR			Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	46										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						AGCATTAATGAACTTGATGTT	0.413													6	20					0	0	1	0	0	C	82909623	A	C	82909623	3	2	48	1	0	0	0	0	1	0	0	0	664	261	9	4		4	ANKRD42	11	82909623	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	31388	82909623	52096893	2690	7084										
DLG2	1740	broad.mit.edu	37	chr11	84245767	84245767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcgtcctcatcttgatatCgatacttctaggagaaaaga	9	8	3	3	rs150043290	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:84245767C>T	ENST00000398309.2	-	2	520	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	DLG2_ENST00000543673.1_Missense_Mutation_p.R122Q|DLG2_ENST00000376104.2_Missense_Mutation_p.R122Q|DLG2_ENST00000524982.1_Missense_Mutation_p.R17Q|DLG2_ENST00000532653.1_Missense_Mutation_p.R17Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	17						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				ATCTTGATATCGATACTTCTA	0.388													38	71					0	0	1	0	0	T	84245767	C	T	84245767	3	4	48	1	0	0	0	0	1	0	0	0	4583	884	31	1	2809	1	DLG2	11	84245767	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1336144	84245767	50760749	2691	7085										
CCDC89	220388	broad.mit.edu	37	chr11	85396557	85396557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagcagctccttctcgcgcGcctgtgcctggcaggcatcc	11	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:85396557G>A	ENST00000316398.3	-	1	763	c.617C>T	c.(616-618)gCg>gTg	p.A206V		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	206						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CTTCTCGCGCGCCTGTGCCTG	0.617													42	117					0	0	1	0	0	A	85396557	G	A	85396557	3	1	48	1	0	0	0	0	1	0	0	0	2886	1087	38	1	511	1	CCDC89	11	85396557	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1150790	85396557	49609959	2692	7086										
CCDC89	220388	broad.mit.edu	37	chr11	85396938	85396938	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctgacctccgcttcaggAtgcagatgagctgggactgc	12	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:85396938A>C	ENST00000316398.3	-	1	382	c.236T>G	c.(235-237)aTc>aGc	p.I79S		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	79						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CCGCTTCAGGATGCAGATGAG	0.587													4	44					0	0	1	0	0	C	85396938	A	C	85396938	3	2	48	1	0	0	0	0	1	0	0	0	2886	333	12	4	892	4	CCDC89	11	85396938	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	381	85396938	49609578	2693	7087										
SYTL2	54843	broad.mit.edu	37	chr11	85407247	85407247	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttccaaagccaatacgaaGacctcccaaaaattggttgg	8	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:85407247G>T	ENST00000359152.5	-	11	5175	c.5176C>A	c.(5176-5178)Ctt>Att	p.L1726I	SYTL2_ENST00000527523.1_Missense_Mutation_p.L848I|SYTL2_ENST00000524452.1_Missense_Mutation_p.L856I|SYTL2_ENST00000316356.4_Missense_Mutation_p.L881I|SYTL2_ENST00000533892.1_Missense_Mutation_p.L282I|SYTL2_ENST00000528231.1_Missense_Mutation_p.L880I|SYTL2_ENST00000354566.3_Missense_Mutation_p.L1218I|SYTL2_ENST00000525423.1_Missense_Mutation_p.L1202I|SYTL2_ENST00000389960.4_Missense_Mutation_p.L856I|SYTL2_ENST00000529581.1_Missense_Mutation_p.L322I|SYTL2_ENST00000389958.3_Missense_Mutation_p.L311I|SYTL2_ENST00000525702.1_Missense_Mutation_p.L322I	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	880					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCAATACGAAGACCTCCCAAA	0.403													28	53					5.45727e-16	7.22369e-16	1	1	0	T	85407247	G	T	85407247	3	4	48	1	0	0	0	0	1	0	0	0	15539	942	33	2	174	2	SYTL2	11	85407247	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10309	85407247	49599269	2694	7088										
CCDC83	220047	broad.mit.edu	37	chr11	85623738	85623738	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctaatcctcgtcatctgCtgctgctgcctttggaatca	7	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:85623738C>A	ENST00000280245.4	+	9	1353	c.841C>A	c.(841-843)Ctg>Atg	p.L281M	CCDC83_ENST00000376067.1_Intron|CCDC83_ENST00000529676.2_Intron|CCDC83_ENST00000342404.3_Intron	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	265										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TCGTCATCTGCTGCTGCTGCC	0.512													6	204					3.59834e-05	3.93264e-05	1	1	0	A	85623738	C	A	85623738	3	1	48	1	0	0	0	0	1	0	0	0	2877	796	28	5	871	5	CCDC83	11	85623738	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	216491	85623738	49382778	2695	7089										
RAB38	23682	broad.mit.edu	37	chr11	87847193	87847193	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagagcagctggcaaccttgGttgatgtgagatggggcttc	15	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:87847193G>A	ENST00000243662.6	-	3	681	c.599C>T	c.(598-600)aCc>aTc	p.T200I	RP11-164N3.3_ENST00000528458.1_RNA	NM_022337.2	NP_071732.1	P57729	RAB38_HUMAN	RAB38, member RAS oncogene family	200					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGCAACCTTGGTTGATGTGAG	0.493													39	66					0	0	1	0	0	A	87847193	G	A	87847193	3	1	48	1	0	0	0	0	1	0	0	0	12979	1261	44	3	40	3	RAB38	11	87847193	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2223455	87847193	47159323	2696	7090										
NAALAD2	10003	broad.mit.edu	37	chr11	89868834	89868834	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaaaacatcaaatcatttCttcggtaagtttattttacg	5	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:89868834C>A	ENST00000534061.1	+	2	420	c.190C>A	c.(190-192)Ctt>Att	p.L64I	NAALAD2_ENST00000375944.3_Missense_Mutation_p.L64I|NAALAD2_ENST00000321955.4_Missense_Mutation_p.L64I|NAALAD2_ENST00000525171.1_Missense_Mutation_p.L64I	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	64					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CAAATCATTTCTTCGGTAAGT	0.343													13	17					7.03913e-09	8.36985e-09	1	1	0	A	89868834	C	A	89868834	3	1	48	1	0	0	0	0	1	0	0	0	10175	913	32	2	196	2	NAALAD2	11	89868834	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2021641	89868834	45137682	2697	7091										
CHORDC1	26973	broad.mit.edu	37	chr11	89944398	89944398	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttacctttcttattttcttCattccctgatgacagtttaa	3	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:89944398C>A	ENST00000320585.6	-	5	827	c.418G>T	c.(418-420)Gaa>Taa	p.E140*	CHORDC1_ENST00000457199.2_Nonsense_Mutation_p.E121*	NM_012124.2	NP_036256.2	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain (CHORD) containing 1	140	Interaction with HSP90AA1 and HSP90AB1 (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding	p.E140*(1)		endometrium(2)|large_intestine(2)|liver(1)|lung(6)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				TTATTTTCTTCATTCCCTGAT	0.303													22	43					1.10923e-09	1.34134e-09	1	1	0	A	89944398	C	A	89944398	4	1	48	1	0	0	0	0	0	1	0	0	3387	835	29	2	608	2	CHORDC1	11	89944398	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	75564	89944398	45062118	2698	7092										
FAT3	120114	broad.mit.edu	37	chr11	92085936	92085936	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccttaagtggtcgattaAattatgatgaaaagaatagg	9	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:92085936A>C	ENST00000298047.6	+	1	675	c.658A>C	c.(658-660)Aat>Cat	p.N220H	FAT3_ENST00000525166.1_Missense_Mutation_p.N70H|FAT3_ENST00000541502.1_Missense_Mutation_p.N220H|FAT3_ENST00000409404.2_Missense_Mutation_p.N220H			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	220	Cadherin 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGTCGATTAAATTATGATGA	0.383										TCGA Ovarian(4;0.039)			32	59					0	0	1	0	0	C	92085936	A	C	92085936	3	2	48	1	0	0	0	0	1	0	0	0	5723	14	1	4	660	4	FAT3	11	92085936	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2141538	92085936	42920580	2699	7093										
FAT3	120114	broad.mit.edu	37	chr11	92087781	92087781	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccagtttttattcaagacAgttactcagttaacattctt	5	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:92087781A>C	ENST00000298047.6	+	1	2520	c.2503A>C	c.(2503-2505)Agt>Cgt	p.S835R	FAT3_ENST00000525166.1_Missense_Mutation_p.S685R|FAT3_ENST00000541502.1_Missense_Mutation_p.S835R|FAT3_ENST00000409404.2_Missense_Mutation_p.S835R			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	835	Cadherin 8.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATTCAAGACAGTTACTCAGT	0.398										TCGA Ovarian(4;0.039)			20	17					0	0	1	0	0	C	92087781	A	C	92087781	3	2	48	1	0	0	0	0	1	0	0	0	5723	188	7	4	2505	4	FAT3	11	92087781	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1845	92087781	42918735	2700	7094										
FAT3	120114	broad.mit.edu	37	chr11	92498214	92498214	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaattgtaggggtggtgtCtgtgcagccagctaacaccc	13	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:92498214C>A	ENST00000298047.6	+	5	4171	c.4154C>A	c.(4153-4155)tCt>tAt	p.S1385Y	FAT3_ENST00000525166.1_Missense_Mutation_p.S1235Y|RP11-203F8.1_ENST00000529884.1_RNA|FAT3_ENST00000409404.2_Missense_Mutation_p.S1385Y			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1385	Cadherin 13.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGGGTGGTGTCTGTGCAGCCA	0.438										TCGA Ovarian(4;0.039)			10	20					0.00621372	0.0064192	1	1	0	A	92498214	C	A	92498214	3	1	48	1	0	0	0	0	1	0	0	0	5723	913	32	2	4172	2	FAT3	11	92498214	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	410433	92498214	42508302	2701	7095										
FAT3	120114	broad.mit.edu	37	chr11	92532534	92532534	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaaggtccaaatggagaaGtgacctatgtcctgcaggat	11	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:92532534G>T	ENST00000298047.6	+	9	6372	c.6355G>T	c.(6355-6357)Gtg>Ttg	p.V2119L	FAT3_ENST00000525166.1_Missense_Mutation_p.V1969L|FAT3_ENST00000409404.2_Missense_Mutation_p.V2119L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2119	Cadherin 19.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAATGGAGAAGTGACCTATGT	0.443										TCGA Ovarian(4;0.039)			6	14					0.00116845	0.00122532	1	1	0	T	92532534	G	T	92532534	3	4	48	1	0	0	0	0	1	0	0	0	5723	1029	36	5	6389	5	FAT3	11	92532534	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	34320	92532534	42473982	2702	7096										
SLC36A4	120103	broad.mit.edu	37	chr11	92901248	92901248	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaagcaaagcatatatatCcttaggtcaacacttcttct	5	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:92901248C>T	ENST00000326402.4	-	7	760	c.630G>A	c.(628-630)agG>agA	p.R210R	SLC36A4_ENST00000529184.1_Silent_p.R75R	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	210					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCATATATATCCTTAGGTCAA	0.348													17	35					0	0	1	0	0	T	92901248	C	T	92901248	2	4	48	1	0	0	0	0	0	0	0	1	14650	854	30	3		3	SLC36A4	11	92901248	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	368714	92901248	42105268	2703	7097										
CCDC67	159989	broad.mit.edu	37	chr11	93104221	93104221	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaaacaggcacaaagttaCcaaactcaactaaatggtaa	6	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:93104221C>G	ENST00000298050.3	+	7	664	c.564C>G	c.(562-564)taC>taG	p.Y188*		NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	188										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				CACAAAGTTACCAAACTCAAC	0.323													10	11					0	0	1	0	0	G	93104221	C	G	93104221	4	3	48	1	0	0	0	0	0	1	0	0	2859	518	18	5	586	5	CCDC67	11	93104221	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	202973	93104221	41902295	2704	7098										
C11orf54	28970	broad.mit.edu	37	chr11	93487178	93487178	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggagcaggagcaggtccatTtcagactctcgggttcaatt	12	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:93487178T>G	ENST00000528288.1	+	5	540	c.305T>G	c.(304-306)tTt>tGt	p.F102C	C11orf54_ENST00000540113.1_Missense_Mutation_p.F83C|C11orf54_ENST00000528099.1_Missense_Mutation_p.F102C|C11orf54_ENST00000354421.3_Missense_Mutation_p.F102C|C11orf54_ENST00000331239.4_Missense_Mutation_p.F102C	NM_014039.2	NP_054758.2	Q9H0W9	CK054_HUMAN	chromosome 11 open reading frame 54	102						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(5)	8		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCAGGTCCATTTCAGACTCTC	0.338													8	99					0	0	1	0	0	G	93487178	T	G	93487178	3	3	48	1	0	0	0	0	1	0	0	0	1654	1841	64	4	319	4	C11orf54	11	93487178	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	382957	93487178	41519338	2705	7099										
HEPHL1	341208	broad.mit.edu	37	chr11	93796740	93796740	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catggttcctcctgggaaaaActacacctacgtctggccgg	10	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:93796740A>G	ENST00000315765.9	+	3	490	c.482A>G	c.(481-483)aAc>aGc	p.N161S		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	161	Plastocyanin-like 1.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CCTGGGAAAAACTACACCTAC	0.458													17	34					0	0	1	0	0	G	93796740	A	G	93796740	3	3	48	1	0	0	0	0	1	0	0	0	7095	43	2	4	492	4	HEPHL1	11	93796740	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	309562	93796740	41209776	2706	7100										
MRE11A	4361	broad.mit.edu	37	chr11	94178996	94178996	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctataatagacatatttCtagatgctgacacagcagtc	6	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94178996C>A	ENST00000323929.3	-	16	2069	c.1847G>T	c.(1846-1848)aGa>aTa	p.R616I	MRE11A_ENST00000393241.4_Missense_Mutation_p.R615I|MRE11A_ENST00000323977.3_Intron|MRE11A_ENST00000407439.3_Missense_Mutation_p.R619I	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	616					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				AGACATATTTCTAGATGCTGA	0.383								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				30	52					1.74807e-11	2.17561e-11	1	1	0	A	94178996	C	A	94178996	3	1	48	1	0	0	0	0	1	0	0	0	9807	913	32	2	299	2	MRE11A	11	94178996	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	382256	94178996	40827520	2707	7101										
MRE11A	4361	broad.mit.edu	37	chr11	94224044	94224044	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttcatcgagtgttacaaaCgtatcatttcctctgactgc	6	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94224044C>T	ENST00000323929.3	-	3	330	c.108G>A	c.(106-108)acG>acA	p.T36T	MRE11A_ENST00000393241.4_Silent_p.T36T|MRE11A_ENST00000323977.3_Silent_p.T36T|MRE11A_ENST00000536144.1_5'UTR|MRE11A_ENST00000407439.3_Silent_p.T39T|MRE11A_ENST00000540013.1_Silent_p.T36T	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	36					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				GTGTTACAAACGTATCATTTC	0.328								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				19	51					0	0	1	0	0	T	94224044	C	T	94224044	2	4	48	1	0	0	0	0	0	0	0	1	9807	523	19	1		1	MRE11A	11	94224044	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	45048	94224044	40782472	2708	7102										
ANKRD49	54851	broad.mit.edu	37	chr11	94229989	94229989	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctactggtactcaaagtCtttgggtaggcaattctgat	9	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94229989C>A	ENST00000544253.1	+	2	248	c.130C>A	c.(130-132)Ctt>Att	p.L44I	ANKRD49_ENST00000540349.1_Missense_Mutation_p.L44I|ANKRD49_ENST00000544612.1_Missense_Mutation_p.L44I|ANKRD49_ENST00000302755.4_Missense_Mutation_p.L44I			Q8WVL7	ANR49_HUMAN	ankyrin repeat domain 49	44					positive regulation of transcription, DNA-dependent					autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|urinary_tract(1)	12		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TACTCAAAGTCTTTGGGTAGG	0.373													12	105					3.07112e-06	3.42433e-06	1	1	0	A	94229989	C	A	94229989	3	1	48	1	0	0	0	0	1	0	0	0	669	913	32	2	132	2	ANKRD49	11	94229989	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5945	94229989	40776527	2709	7103										
PIWIL4	143689	broad.mit.edu	37	chr11	94310616	94310616	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaacaaagcaaaagcattCgacggtgccatcctttttct	6	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94310616C>T	ENST00000299001.6	+	4	682	c.471C>T	c.(469-471)ttC>ttT	p.F157F	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	157					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CAAAAGCATTCGACGGTGCCA	0.343													15	21					0	0	1	0	0	T	94310616	C	T	94310616	2	4	48	1	0	0	0	0	0	0	0	1	12007	883	31	1		1	PIWIL4	11	94310616	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80627	94310616	40695900	2710	7104										
PIWIL4	143689	broad.mit.edu	37	chr11	94318621	94318621	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacttgcaggatcctcaaaAagttgtccatgtaccaaatt	6	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94318621A>C	ENST00000299001.6	+	6	857	c.646A>C	c.(646-648)Aag>Cag	p.K216Q	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	216					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GATCCTCAAAAAGTTGTCCAT	0.333													33	75					0	0	1	0	0	C	94318621	A	C	94318621	3	2	48	1	0	0	0	0	1	0	0	0	12007	15	1	4	668	4	PIWIL4	11	94318621	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	8005	94318621	40687895	2711	7105										
PIWIL4	143689	broad.mit.edu	37	chr11	94322371	94322371	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaagcgggatggcaccgaGatcacctatgtggattacta	12	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94322371G>T	ENST00000299001.6	+	8	1210	c.999G>T	c.(997-999)gaG>gaT	p.E333D	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	333	PAZ.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATGGCACCGAGATCACCTATG	0.423													20	45					2.4624e-09	2.95225e-09	1	1	0	T	94322371	G	T	94322371	3	4	48	1	0	0	0	0	1	0	0	0	12007	933	33	2	1029	2	PIWIL4	11	94322371	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3750	94322371	40684145	2712	7106										
KDM4D	55693	broad.mit.edu	37	chr11	94732052	94732052	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagcctgtaccactgagcCcagggctccagcatcctgtc	9	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:94732052C>T	ENST00000335080.5	+	3	2348	c.1516C>T	c.(1516-1518)Cca>Tca	p.P506S	KDM4D_ENST00000536741.1_Missense_Mutation_p.P506S	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	506					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						ACCACTGAGCCCAGGGCTCCA	0.617													19	24					0	0	1	0	0	T	94732052	C	T	94732052	3	4	48	1	0	0	0	0	1	0	0	0	8174	623	22	3	1518	3	KDM4D	11	94732052	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	409681	94732052	40274464	2713	7107										
MTMR2	8898	broad.mit.edu	37	chr11	95578263	95578263	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accatcactgcaatgcactaCcacagacgtcttccctgact	5	16	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:95578263C>T	ENST00000393223.3	-	13	1686	c.1024G>A	c.(1024-1026)Gta>Ata	p.V342I	MTMR2_ENST00000352297.7_Missense_Mutation_p.V342I|MTMR2_ENST00000409459.1_Missense_Mutation_p.V342I|MTMR2_ENST00000346299.5_Missense_Mutation_p.V414I	NM_001243571.1|NM_201278.2	NP_001230500.1|NP_958435.1	Q13614	MTMR2_HUMAN	myotubularin related protein 2	414	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAATGCACTACCACAGACGTC	0.448													21	29					0	0	1	0	0	T	95578263	C	T	95578263	3	4	48	1	0	0	0	0	1	0	0	0	9991	507	18	3	711	3	MTMR2	11	95578263	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	846211	95578263	39428253	2714	7108										
MAML2	84441	broad.mit.edu	37	chr11	95826576	95826576	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagagattctccccaacacGaattcttttgatatcaagaa	6	9	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:95826576G>A	ENST00000524717.1	-	2	1903	c.619C>T	c.(619-621)Cgt>Tgt	p.R207C		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	207					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TCCCCAACACGAATTCTTTTG	0.458			T	"MECT1, CRTC3"	salivary gland mucoepidermoid								26	57					0	0	1	0	0	A	95826576	G	A	95826576	3	1	48	1	0	0	0	0	1	0	0	0	9255	1058	37	1	2867	1	MAML2	11	95826576	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	248313	95826576	39179940	2715	7109										
JRKL	8690	broad.mit.edu	37	chr11	96123832	96123832	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatgtcagggaaacggaagCgtgtggtgttgactattaaa	13	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:96123832C>T	ENST00000458427.1	+	1	675	c.19C>T	c.(19-21)Cgt>Tgt	p.R7C	JRKL_ENST00000332349.4_Missense_Mutation_p.R7C|JRKL_ENST00000546177.1_Intron	NM_003772.3	NP_003763.2	Q9Y4A0	JERKL_HUMAN	jerky homolog-like (mouse)	7	HTH psq-type.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		GAAACGGAAGCGTGTGGTGTT	0.428													14	34					0	0	1	0	0	T	96123832	C	T	96123832	3	4	48	1	0	0	0	0	1	0	0	0	8008	768	27	1	21	1	JRKL	11	96123832	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	297256	96123832	38882684	2716	7110										
CNTN5	53942	broad.mit.edu	37	chr11	99827539	99827539	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattttgtgtattttcagaGatcatctatagctgggtatt	8	4	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:99827539G>T	ENST00000524871.1	+	8	965	c.673_splice	c.e8-1	p.E225_splice	CNTN5_ENST00000418526.2_Splice_Site_p.E151_splice|CNTN5_ENST00000528682.1_Splice_Site_p.E225_splice|CNTN5_ENST00000279463.3_Splice_Site_p.E225_splice|CNTN5_ENST00000527185.1_Splice_Site_p.E225_splice	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	225	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TATTTTCAGAGATCATCTATA	0.383													4	21					0.150653	0.151842	1	1	0	T	99827539	G	T	99827539	5	4	48	1	0	0	0	0	0	0	1	0	3667	956	33	2	697	2	CNTN5	11	99827539	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3703707	99827539	35178977	2717	7111										
CNTN5	53942	broad.mit.edu	37	chr11	99872788	99872788	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatgggagaatatgagccGaaaattgaggtccattttcc	12	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:99872788G>A	ENST00000524871.1	+	9	1190	c.900G>A	c.(898-900)ccG>ccA	p.P300P	CNTN5_ENST00000418526.2_Silent_p.P226P|CNTN5_ENST00000528682.1_Silent_p.P300P|CNTN5_ENST00000279463.3_Silent_p.P300P|CNTN5_ENST00000527185.1_Silent_p.P300P	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	300	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AATATGAGCCGAAAATTGAGG	0.363													3	4					0	0	1	0	0	A	99872788	G	A	99872788	2	1	48	1	0	0	0	0	0	0	0	1	3667	1045	37	1		1	CNTN5	11	99872788	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	45249	99872788	35133728	2718	7112										
PGR	5241	broad.mit.edu	37	chr11	100922293	100922293	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcatcaatatgtaagtttCgaaaacctacaaaacaaatt	5	7	2	0	rs149186732	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:100922293C>T	ENST00000325455.5	-	5	3672	c.2219G>A	c.(2218-2220)cGa>cAa	p.R740Q	PGR_ENST00000534013.1_Missense_Mutation_p.R146Q|PGR_ENST00000263463.5_Missense_Mutation_p.R638Q	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	740	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding	p.R740Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ATGTAAGTTTCGAAAACCTAC	0.328													17	28					0	0	1	0	0	T	100922293	C	T	100922293	3	4	48	1	0	0	0	0	1	0	0	0	11852	884	31	1	598	1	PGR	11	100922293	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1049505	100922293	34084223	2719	7113										
TRPC6	7225	broad.mit.edu	37	chr11	101362288	101362288	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttcacgcctgaccttactTtttttacttcatatttaatg	4	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:101362288T>G	ENST00000344327.3	-	3	1551	c.1128_splice	c.e3+1	p.K376_splice	TRPC6_ENST00000532133.1_Splice_Site_p.K376_splice|TRPC6_ENST00000360497.4_Splice_Site_p.K376_splice|TRPC6_ENST00000348423.4_Intron	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	376					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGACCTTACTTTTTTTACTTC	0.403													50	80					0	0	1	0	0	G	101362288	T	G	101362288	5	3	48	1	0	0	0	0	0	0	1	0	16643	1855	64	4	1712	4	TRPC6	11	101362288	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	439995	101362288	33644228	2720	7114										
KIAA1377	57562	broad.mit.edu	37	chr11	101833270	101833270	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaattgaaagatggtaaaGaagaagagataaaatatttt	9	0	0	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:101833270G>T	ENST00000263468.8	+	6	1774	c.1504G>T	c.(1504-1506)Gaa>Taa	p.E502*	KIAA1377_ENST00000537689.1_Nonsense_Mutation_p.E303*	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	502							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AGATGGTAAAGAAGAAGAGAT	0.323													10	10					0.00829132	0.00855608	1	1	0	T	101833270	G	T	101833270	4	4	48	1	0	0	0	0	0	1	0	0	8268	943	33	2	1526	2	KIAA1377	11	101833270	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	470982	101833270	33173246	2721	7115										
MMP1	4312	broad.mit.edu	37	chr11	102665933	102665933	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagaacatcacttctccccGaatcgtagttatagcatcaa	5	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:102665933G>A	ENST00000315274.6	-	6	938	c.871C>T	c.(871-873)Cgg>Tgg	p.R291W	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	291	Hemopexin-like 1.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		ACTTCTCCCCGAATCGTAGTT	0.398													6	94					0	0	1	0	0	A	102665933	G	A	102665933	3	1	48	1	0	0	0	0	1	0	0	0	9695	1057	37	1	558	1	MMP1	11	102665933	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	832663	102665933	32340583	2722	7116										
MMP12	4321	broad.mit.edu	37	chr11	102736613	102736613	+	RNA	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaccaaaagaatgtatgcTcttgggataatttggctctg	9	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:102736613T>G	ENST00000532855.1	-	0	1194							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GAATGTATGCTCTTGGGATAA	0.328													13	23					0	0	1	0	0	G	102736613	T	G	102736613	1	3	48	0	1	0	0	0	0	0	0	0	9698	1551	54	4		4	MMP12	11	102736613	RNA	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	70680	102736613	32269903	2723	7117										
MMP13	4322	broad.mit.edu	37	chr11	102815028	102815028	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggaatttgctggcatgacGcgaacaatacggttactcca	10	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:102815028G>A	ENST00000260302.3	-	10	1411	c.1383C>T	c.(1381-1383)cgC>cgT	p.R461R		NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	461	Hemopexin-like 4.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		CTGGCATGACGCGAACAATAC	0.358													18	159					0	0	1	0	0	A	102815028	G	A	102815028	2	1	48	1	0	0	0	0	0	0	0	1	9699	1074	38	1		1	MMP13	11	102815028	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	78415	102815028	32191488	2724	7118										
DYNC2H1	79659	broad.mit.edu	37	chr11	103027492	103027492	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttcaacagagttgatgaaGattttaggtcagtacaatga	10	5	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:103027492G>A	ENST00000375735.2	+	26	4264	c.4120G>A	c.(4120-4122)Gat>Aat	p.D1374N	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.D1374N	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1374	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGTTGATGAAGATTTTAGGTC	0.338													19	35					0	0	1	0	0	A	103027492	G	A	103027492	3	1	48	1	0	0	0	0	1	0	0	0	4872	942	33	3	4222	3	DYNC2H1	11	103027492	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	212464	103027492	31979024	2725	7119										
DDI1	414301	broad.mit.edu	37	chr11	103908440	103908440	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaggagtgggcacacagaGaattattggccgtgttcatc	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:103908440G>T	ENST00000302259.3	+	1	1133	c.890G>T	c.(889-891)aGa>aTa	p.R297I	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	297					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GGCACACAGAGAATTATTGGC	0.483													7	86					0.00198382	0.00207034	1	1	0	T	103908440	G	T	103908440	3	4	48	1	0	0	0	0	1	0	0	0	4351	942	33	2	892	2	DDI1	11	103908440	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	880948	103908440	31098076	2726	7120										
DDI1	414301	broad.mit.edu	37	chr11	103908701	103908701	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagtcttcggacaaggaaaTtacacattcagtcatggatt	9	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:103908701T>A	ENST00000302259.3	+	1	1394	c.1151T>A	c.(1150-1152)aTt>aAt	p.I384N	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	384					proteolysis		aspartic-type endopeptidase activity	p.I384S(1)		central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GACAAGGAAATTACACATTCA	0.458													16	17					0	0	1	0	0	A	103908701	T	A	103908701	3	1	48	1	0	0	0	0	1	0	0	0	4351	1493	52	4	1153	4	DDI1	11	103908701	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	261	103908701	31097815	2727	7121										
KBTBD3	143879	broad.mit.edu	37	chr11	105924041	105924041	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatctctacctctgatccaaGaacataaattacattttggc	4	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:105924041G>T	ENST00000526793.1	-	3	1534	c.1375C>A	c.(1375-1377)Ctt>Att	p.L459I	KBTBD3_ENST00000534815.1_Missense_Mutation_p.L380I|KBTBD3_ENST00000531837.1_Missense_Mutation_p.L459I	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	455										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCTGATCCAAGAACATAAATT	0.373													8	23					0.000157383	0.000169016	1	1	0	T	105924041	G	T	105924041	3	4	48	1	0	0	0	0	1	0	0	0	8037	942	33	2	467	2	KBTBD3	11	105924041	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2015340	105924041	29082475	2728	7122										
ATM	472	broad.mit.edu	37	chr11	108165729	108165729	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaaggactaaaggatcttCgaagacaactggaactacat	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:108165729C>T	ENST00000278616.4	+	32	5237	c.4852C>T	c.(4852-4854)Cga>Tga	p.R1618*	ATM_ENST00000452508.2_Nonsense_Mutation_p.R1618*	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1618					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.E1612_Q1620>*(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AAAGGATCTTCGAAGACAACT	0.358			"D, Mis, N, F, S"		T-PLL	"leukemia, lymphoma, medulloblastoma, glioma"		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			24	45					0	0	1	0	0	T	108165729	C	T	108165729	4	4	48	1	0	0	0	0	0	1	0	0	1108	876	31	1	4974	1	ATM	11	108165729	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2241688	108165729	26840787	2729	7123										
ATM	472	broad.mit.edu	37	chr11	108235812	108235812	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgttctctctgtttaggtcCttctatatgatccactcttt	5	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:108235812C>A	ENST00000278616.4	+	62	9239	c.8854C>A	c.(8854-8856)Ctt>Att	p.L2952I	C11orf65_ENST00000526725.1_Intron|C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.L2952I|ATM_ENST00000525178.1_3'UTR	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2952	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.L2952F(2)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGTTTAGGTCCTTCTATATGA	0.368			"D, Mis, N, F, S"		T-PLL	"leukemia, lymphoma, medulloblastoma, glioma"		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			13	22					0.000151284	0.00016287	1	1	0	A	108235812	C	A	108235812	3	1	48	1	0	0	0	0	1	0	0	0	1108	681	24	5	9096	5	ATM	11	108235812	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	70083	108235812	26770704	2730	7124										
EXPH5	23086	broad.mit.edu	37	chr11	108380999	108380999	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcctcctctgattgtcagaGaattctgcttccctgaggct	9	12	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:108380999G>T	ENST00000265843.4	-	6	5345	c.5235C>A	c.(5233-5235)ttC>ttA	p.F1745L	EXPH5_ENST00000428840.1_Missense_Mutation_p.F1669L|EXPH5_ENST00000443411.1_Missense_Mutation_p.F1557L|EXPH5_ENST00000525344.1_Missense_Mutation_p.F1738L	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1745					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GATTGTCAGAGAATTCTGCTT	0.488													38	78					1.06647e-15	1.40869e-15	1	1	0	T	108380999	G	T	108380999	3	4	48	1	0	0	0	0	1	0	0	0	5350	933	33	2	738	2	EXPH5	11	108380999	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	145187	108380999	26625517	2731	7125										
RDX	5962	broad.mit.edu	37	chr11	110134819	110134819	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggcaatatatctcatcattTaagatggcttctttaacttg	7	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:110134819T>C	ENST00000343115.4	-	5	652	c.333A>G	c.(331-333)ttA>ttG	p.L111L	RDX_ENST00000528900.1_Intron|RDX_ENST00000530301.1_Silent_p.L79L|RDX_ENST00000405097.1_Silent_p.L111L|RDX_ENST00000528498.1_Silent_p.L111L|RDX_ENST00000544551.1_Intron	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	111	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TCTCATCATTTAAGATGGCTT	0.373													22	25					0	0	1	0	0	C	110134819	T	C	110134819	2	2	48	1	0	0	0	0	0	0	0	1	13249	1751	61	4		4	RDX	11	110134819	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1753820	110134819	24871697	2732	7126										
SIK2	23235	broad.mit.edu	37	chr11	111583042	111583042	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggccttttcatttccagcAtctggctgtcaggcggaagc	12	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:111583042A>G	ENST00000304987.3	+	9	1382	c.1209A>G	c.(1207-1209)gcA>gcG	p.A403A		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	403					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						CATTTCCAGCATCTGGCTGTC	0.557													20	35					0	0	1	0	0	G	111583042	A	G	111583042	2	3	48	1	0	0	0	0	0	0	0	1	14372	204	8	4		4	SIK2	11	111583042	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1448223	111583042	23423474	2733	7127										
CRYAB	1410	broad.mit.edu	37	chr11	111779674	111779674	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctgtggaactccctggaGatgaaaccatgttcatccta	8	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:111779674G>T	ENST00000533475.1	-	4	791	c.342C>A	c.(340-342)atC>atA	p.I114I	CRYAB_ENST00000531198.1_Silent_p.I114I|CRYAB_ENST00000526180.1_Silent_p.I114I|CRYAB_ENST00000525823.1_Silent_p.I47I|CRYAB_ENST00000533280.1_Silent_p.I47I|CRYAB_ENST00000527950.1_Silent_p.I114I|CRYAB_ENST00000227251.3_Silent_p.I114I	NM_001885.1	NP_001876.1	P02511	CRYAB_HUMAN	crystallin, alpha B	114					anti-apoptosis|muscle contraction|negative regulation of intracellular transport|protein folding|protein homooligomerization|response to heat	cytoplasm|nucleus	protein homodimerization activity|structural constituent of eye lens|unfolded protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(4)	8		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		ACTCCCTGGAGATGAAACCAT	0.473													11	34					0.0692343	0.0701576	1	1	0	T	111779674	G	T	111779674	2	4	48	1	0	0	0	0	0	0	0	1	3929	932	33	2		2	CRYAB	11	111779674	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	196632	111779674	23226842	2734	7128										
NCAM1	4684	broad.mit.edu	37	chr11	113102483	113102483	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accgccagcaacaccatcggCcaggactcccagtccatgta	8	17	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113102483C>A	ENST00000316851.7	+	9	1176	c.1176C>A	c.(1174-1176)ggC>ggA	p.G392G	NCAM1_ENST00000533760.1_Silent_p.G274G|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.G401G	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	402	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ACACCATCGGCCAGGACTCCC	0.577													11	109					1.08611e-07	1.25818e-07	1	1	0	A	113102483	C	A	113102483	2	1	48	1	0	0	0	0	0	0	0	1	10248	726	26	5		5	NCAM1	11	113102483	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1322809	113102483	21904033	2735	7129										
NCAM1	4684	broad.mit.edu	37	chr11	113102991	113102991	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatcccagtgccacgatctCatggtttcgggatggccagc	11	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113102991C>A	ENST00000316851.7	+	10	1310	c.1310C>A	c.(1309-1311)tCa>tAa	p.S437*	NCAM1_ENST00000533760.1_Nonsense_Mutation_p.S319*|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Nonsense_Mutation_p.S446*	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	447	Ig-like C2-type 5.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCCACGATCTCATGGTTTCGG	0.552													15	42					0.000308642	0.000328443	1	1	0	A	113102991	C	A	113102991	4	1	48	1	0	0	0	0	0	1	0	0	10248	838	29	2	1383	2	NCAM1	11	113102991	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	508	113102991	21903525	2736	7130										
ANKK1	255239	broad.mit.edu	37	chr11	113270689	113270689	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggacacccctccacctggcGgtccagaggagcaccttcct	10	17	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113270689G>A	ENST00000303941.3	+	8	2092	c.1998G>A	c.(1996-1998)gcG>gcA	p.A666A		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	666							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TCCACCTGGCGGTCCAGAGGA	0.647													26	47					0	0	1	0	0	A	113270689	G	A	113270689	2	1	48	1	0	0	0	0	0	0	0	1	627	1103	39	1		1	ANKK1	11	113270689	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	167698	113270689	21735827	2737	7131										
DRD2	1813	broad.mit.edu	37	chr11	113285165	113285165	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgcagagtttcatgtcctCggggtgagtacagttgccct	14	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113285165C>T	ENST00000362072.3	-	6	1086	c.742G>A	c.(742-744)Gag>Aag	p.E248K	DRD2_ENST00000542968.1_Missense_Mutation_p.E248K|DRD2_ENST00000538967.1_Missense_Mutation_p.E248K|DRD2_ENST00000355319.2_Missense_Mutation_p.E248K|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000346454.3_Intron|DRD2_ENST00000544518.1_Missense_Mutation_p.E247K	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	248	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TTCATGTCCTCGGGGTGAGTA	0.567													58	103					0	0	1	0	0	T	113285165	C	T	113285165	3	4	48	1	0	0	0	0	1	0	0	0	4783	893	31	1	601	1	DRD2	11	113285165	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	14476	113285165	21721351	2738	7132										
ZW10	9183	broad.mit.edu	37	chr11	113614583	113614583	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggcgagttccattaatttCttcacagactcactgatacg	7	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113614583C>A	ENST00000200135.3	-	10	1596	c.1452G>T	c.(1450-1452)aaG>aaT	p.K484N		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	484					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		CCATTAATTTCTTCACAGACT	0.418													30	63					6.00712e-18	8.10414e-18	1	1	0	A	113614583	C	A	113614583	3	1	48	1	0	0	0	0	1	0	0	0	18286	912	32	2	915	2	ZW10	11	113614583	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	329418	113614583	21391933	2739	7133										
USP28	57646	broad.mit.edu	37	chr11	113723356	113723356	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaatgtcaccattactggcCtatgggagaaaaagacaata	9	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113723356C>A	ENST00000003302.4	-	3	204		c.e3-1		USP28_ENST00000260188.5_Splice_Site|USP28_ENST00000545540.1_Intron|USP28_ENST00000542033.1_Splice_Site|USP28_ENST00000537706.1_Splice_Site	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28						cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CATTACTGGCCTATGGGAGAA	0.388													7	42					0.00198382	0.00207034	1	1	0	A	113723356	C	A	113723356	5	1	48	1	0	0	0	0	0	0	1	0	17117	695	24	5	3190	5	USP28	11	113723356	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	108773	113723356	21283160	2740	7134										
HTR3B	9177	broad.mit.edu	37	chr11	113803116	113803116	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctctgcgtgcagtttagaGacatatgcttttccatttga	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:113803116G>T	ENST00000260191.2	+	5	731	c.474G>T	c.(472-474)gaG>gaT	p.E158D	HTR3B_ENST00000537778.1_Missense_Mutation_p.E147D	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	158					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GCAGTTTAGAGACATATGCTT	0.438													28	34					3.73988e-18	5.05028e-18	1	1	0	T	113803116	G	T	113803116	3	4	48	1	0	0	0	0	1	0	0	0	7488	933	33	2	492	2	HTR3B	11	113803116	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	79760	113803116	21203400	2741	7135										
ZNF259	8882	broad.mit.edu	37	chr11	116649650	116649650	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccacccactgctaccgttgCggagccaggcctgcctcata	10	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:116649650C>T	ENST00000227322.3	-	14	1430	c.1371G>A	c.(1369-1371)ccG>ccA	p.P457P		NM_003904.3	NP_003895.1	O75312	ZPR1_HUMAN	zinc finger protein 259	457					cell proliferation|signal transduction	cytoplasm|nucleolus				breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GCTACCGTTGCGGAGCCAGGC	0.532													17	26					0	0	1	0	0	T	116649650	C	T	116649650	2	4	48	1	0	0	0	0	0	0	0	1	17858	755	27	1		1	ZNF259	11	116649650	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2846534	116649650	18356866	2742	7136										
TMPRSS13	84000	broad.mit.edu	37	chr11	117785214	117785214	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtacctgatccctgtgtggCcctgccagaactggactaga	11	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:117785214C>T	ENST00000528626.1	-	3	540	c.467G>A	c.(466-468)gGc>gAc	p.G156D	TMPRSS13_ENST00000430170.2_Missense_Mutation_p.G191D|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.G191D|TMPRSS13_ENST00000526090.1_Missense_Mutation_p.G191D|TMPRSS13_ENST00000524993.1_Missense_Mutation_p.G191D	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	186					proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		CCCTGTGTGGCCCTGCCAGAA	0.587													112	206					0	0	1	0	0	T	117785214	C	T	117785214	3	4	48	1	0	0	0	0	1	0	0	0	16304	739	26	3	1171	3	TMPRSS13	11	117785214	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1135564	117785214	17221302	2743	7137										
AMICA1	120425	broad.mit.edu	37	chr11	118068800	118068800	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaccaagactgtagaattCactgaactgcaagacatgaa	7	9	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:118068800C>A	ENST00000292067.7	-	7	1329	c.888G>T	c.(886-888)gtG>gtT	p.V296V	AMICA1_ENST00000526620.1_Silent_p.V267V|AMICA1_ENST00000533261.1_Silent_p.V295V|AMICA1_ENST00000356289.5_Silent_p.V306V	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	306					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CTGTAGAATTCACTGAACTGC	0.443											OREG0021382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	55					7.26314e-15	9.49782e-15	1	1	0	A	118068800	C	A	118068800	2	1	48	1	0	0	0	0	0	0	0	1	570	813	29	2		2	AMICA1	11	118068800	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	283586	118068800	16937716	2744	7138										
TMEM25	84866	broad.mit.edu	37	chr11	118404598	118404598	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccggcacccatctctgataTcaaggtaactcttccttggg	8	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:118404598T>G	ENST00000524725.1	+	4	1112	c.700T>G	c.(700-702)Tca>Gca	p.S234A	TMEM25_ENST00000354284.4_Missense_Mutation_p.S278A|TMEM25_ENST00000544878.1_Missense_Mutation_p.S181A|TMEM25_ENST00000359862.4_Missense_Mutation_p.S234A|TMEM25_ENST00000442938.2_Missense_Mutation_p.S234A|TMEM25_ENST00000533102.1_Missense_Mutation_p.S278A|TMEM25_ENST00000354064.7_Missense_Mutation_p.S130A|TMEM25_ENST00000411589.2_Missense_Mutation_p.S234A|TMEM25_ENST00000313236.5_Missense_Mutation_p.S278A			Q86YD3	TMM25_HUMAN	transmembrane protein 25	278						extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|stomach(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ATCTCTGATATCAAGGTAACT	0.577													11	130					0	0	1	0	0	G	118404598	T	G	118404598	3	3	48	1	0	0	0	0	1	0	0	0	16209	1435	50	4	850	4	TMEM25	11	118404598	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	335798	118404598	16601918	2745	7139										
VPS11	55823	broad.mit.edu	37	chr11	118952233	118952233	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcagaggtgttttcaacaAattgactctgctgaccgacc	10	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:118952233A>C	ENST00000300793.6	+	17	2765	c.2723A>C	c.(2722-2724)aAa>aCa	p.K908T	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	909					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GTTTTCAACAAATTGACTCTG	0.532													6	104					0	0	1	0	0	C	118952233	A	C	118952233	3	2	48	1	0	0	0	0	1	0	0	0	17247	14	1	4	2787	4	VPS11	11	118952233	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	547635	118952233	16054283	2746	7140										
POU2F3	25833	broad.mit.edu	37	chr11	120139927	120139927	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcttttctaggaaatgatCgaaatggcctagatttcaac	7	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:120139927C>T	ENST00000260264.4	+	3	146	c.112C>T	c.(112-114)Cga>Tga	p.R38*	POU2F3_ENST00000543440.2_Nonsense_Mutation_p.R36*	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	36					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		AGGAAATGATCGAAATGGCCT	0.378													5	22					0	0	1	0	0	T	120139927	C	T	120139927	4	4	48	1	0	0	0	0	0	1	0	0	12318	876	31	1	116	1	POU2F3	11	120139927	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1187694	120139927	14866589	2747	7141										
ARHGEF12	23365	broad.mit.edu	37	chr11	120278467	120278467	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatggaagtattttgaaccGagagtcaccaacagataaga	10	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:120278467G>A	ENST00000397843.2	+	3	243	c.77G>A	c.(76-78)cGa>cAa	p.R26Q	ARHGEF12_ENST00000532993.1_5'UTR|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.R26Q	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	26					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATTTTGAACCGAGAGTCACCA	0.328			T	MLL	AML								29	49					0	0	1	0	0	A	120278467	G	A	120278467	3	1	48	1	0	0	0	0	1	0	0	0	894	1058	37	1	87	1	ARHGEF12	11	120278467	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	138540	120278467	14728049	2748	7142										
GRIK4	2900	broad.mit.edu	37	chr11	120690496	120690496	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagtggccccagaggagttCgtcaagttccagttccagag	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:120690496C>T	ENST00000527524.2	+	6	665	c.378C>T	c.(376-378)ttC>ttT	p.F126F	GRIK4_ENST00000438375.2_Silent_p.F126F			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	126					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CAGAGGAGTTCGTCAAGTTCC	0.532													102	208					0	0	1	0	0	T	120690496	C	T	120690496	2	4	48	1	0	0	0	0	0	0	0	1	6816	883	31	1		1	GRIK4	11	120690496	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	412029	120690496	14316020	2749	7143										
GRIK4	2900	broad.mit.edu	37	chr11	120852900	120852900	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatggctatgttggagttTttatggactctcagacactc	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:120852900T>G	ENST00000527524.2	+	20	2768	c.2481T>G	c.(2479-2481)ttT>ttG	p.F827L	GRIK4_ENST00000438375.2_Missense_Mutation_p.F827L			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	827					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TGTTGGAGTTTTTATGGACTC	0.433													29	83					0	0	1	0	0	G	120852900	T	G	120852900	3	3	48	1	0	0	0	0	1	0	0	0	6816	1838	64	4	2551	4	GRIK4	11	120852900	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	162404	120852900	14153616	2750	7144										
TECTA	7007	broad.mit.edu	37	chr11	121008215	121008215	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttaccctgggccccatctgCgtggatagctgctctgaggg	13	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:121008215C>T	ENST00000392793.1	+	11	3298	c.3027C>T	c.(3025-3027)tgC>tgT	p.C1009C	TECTA_ENST00000264037.2_Silent_p.C1009C			O75443	TECTA_HUMAN	tectorin alpha	1009	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCCCCATCTGCGTGGATAGCT	0.577													33	57					0	0	1	0	0	T	121008215	C	T	121008215	2	4	48	1	0	0	0	0	0	0	0	1	15805	776	27	1		1	TECTA	11	121008215	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	155315	121008215	13998301	2751	7145										
SORL1	6653	broad.mit.edu	37	chr11	121456952	121456952	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaagtgcaatggattccGctgcccaaacggcacttgca	11	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:121456952G>A	ENST00000260197.7	+	27	3857	c.3728G>A	c.(3727-3729)cGc>cAc	p.R1243H	SORL1_ENST00000532694.1_Missense_Mutation_p.R89H|SORL1_ENST00000525532.1_Missense_Mutation_p.R187H|SORL1_ENST00000534286.1_Missense_Mutation_p.R153H	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1243	LDL-receptor class A 5.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AATGGATTCCGCTGCCCAAAC	0.507													39	74					0	0	1	0	0	A	121456952	G	A	121456952	3	1	48	1	0	0	0	0	1	0	0	0	14987	1087	38	1	3834	1	SORL1	11	121456952	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	448737	121456952	13549564	2752	7146										
UBASH3B	84959	broad.mit.edu	37	chr11	122647912	122647912	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatcacactctgccagttCtttatggtgagcggcagcgc	10	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:122647912C>A	ENST00000284273.5	+	3	771	c.396C>A	c.(394-396)ttC>ttA	p.F132L		NM_032873.4	NP_116262.2	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing B	132						cytoplasm|nucleus	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|prostate(1)|skin(2)|stomach(2)	26		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		TCTGCCAGTTCTTTATGGTGA	0.592													12	25					4.3838e-07	4.998e-07	1	1	0	A	122647912	C	A	122647912	3	1	48	1	0	0	0	0	1	0	0	0	16900	912	32	2	406	2	UBASH3B	11	122647912	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1190960	122647912	12358604	2753	7147										
SCN3B	55800	broad.mit.edu	37	chr11	123513189	123513189	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagggggatcagccgcgtcGtcttcacaaagggccgatgc	14	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:123513189G>A	ENST00000392770.2	-	3	1212	c.410C>T	c.(409-411)aCg>aTg	p.T137M	SCN3B_ENST00000299333.3_Missense_Mutation_p.T137M|SCN3B_ENST00000530277.1_Missense_Mutation_p.T137M	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	137	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		CAGCCGCGTCGTCTTCACAAA	0.592													34	43					0	0	1	0	0	A	123513189	G	A	123513189	3	1	48	1	0	0	0	0	1	0	0	0	13972	1145	40	1	249	1	SCN3B	11	123513189	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	865277	123513189	11493327	2754	7148										
OR6M1	390261	broad.mit.edu	37	chr11	123677048	123677048	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttcagtcacagtgctccAgtttcccatgacaactacta	6	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:123677048A>T	ENST00000309154.2	-	1	47	c.10T>A	c.(10-12)Tgg>Agg	p.W4R		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		ACAGTGCTCCAGTTTCCCATG	0.418													4	42					0	0	1	0	0	T	123677048	A	T	123677048	3	4	48	1	0	0	0	0	1	0	0	0	11251	188	7	4	934	4	OR6M1	11	123677048	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	163859	123677048	11329468	2755	7149										
OR4D5	219875	broad.mit.edu	37	chr11	123810531	123810531	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggcaatctttctttcctgGacttttgctactcttccatc	6	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:123810531G>A	ENST00000307033.2	+	1	282	c.208G>A	c.(208-210)Gac>Aac	p.D70N		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTCTTTCCTGGACTTTTGCTA	0.468													32	63					0	0	1	0	0	A	123810531	G	A	123810531	3	1	48	1	0	0	0	0	1	0	0	0	11104	1174	41	3	210	3	OR4D5	11	123810531	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	133483	123810531	11195985	2756	7150										
OR6T1	219874	broad.mit.edu	37	chr11	123814421	123814421	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagcacaataattagcagcTtgcctgtggctgttacaatg	10	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:123814421T>G	ENST00000321252.2	-	1	159	c.125A>C	c.(124-126)aAg>aCg	p.K42T		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AATTAGCAGCTTGCCTGTGGC	0.488													9	135					0	0	1	0	0	G	123814421	T	G	123814421	3	3	48	1	0	0	0	0	1	0	0	0	11256	1609	56	4	849	4	OR6T1	11	123814421	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3890	123814421	11192095	2757	7151										
OR8B2	26595	broad.mit.edu	37	chr11	124253032	124253032	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacagaggagtaacagagatCaatgaaggagagattgaaga	13	3	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124253032C>A	ENST00000375013.2	-	1	226	c.208G>T	c.(208-210)Gat>Tat	p.D70Y		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TAACAGAGATCAATGAAGGAG	0.403													35	104					4.62619e-21	6.37263e-21	1	1	0	A	124253032	C	A	124253032	3	1	48	1	0	0	0	0	1	0	0	0	11273	826	29	2	736	2	OR8B2	11	124253032	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	438611	124253032	10753484	2758	7152										
OR8A1	390275	broad.mit.edu	37	chr11	124440834	124440834	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgacccaggagaatgtggcCtctgtgttctacaccacggt	11	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124440834C>T	ENST00000284287.3	+	1	942	c.870C>T	c.(868-870)gcC>gcT	p.A290A		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		AGAATGTGGCCTCTGTGTTCT	0.502													25	58					0	0	1	0	0	T	124440834	C	T	124440834	2	4	48	1	0	0	0	0	0	0	0	1	11271	668	24	3		3	OR8A1	11	124440834	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	187802	124440834	10565682	2759	7153										
PANX3	116337	broad.mit.edu	37	chr11	124489663	124489663	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttcctccgagctaacatCtctgagctcatctcttttag	5	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124489663C>A	ENST00000284288.2	+	4	1078	c.1011C>A	c.(1009-1011)atC>atA	p.I337I		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	337					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		GAGCTAACATCTCTGAGCTCA	0.428													24	55					6.44725e-10	7.85205e-10	1	1	0	A	124489663	C	A	124489663	2	1	48	1	0	0	0	0	0	0	0	1	11468	903	32	2		2	PANX3	11	124489663	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	48829	124489663	10516853	2760	7154										
ROBO3	64221	broad.mit.edu	37	chr11	124748211	124748211	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggagccaagggaggcaaaGtgaagcttctggggaaacct	15	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124748211G>A	ENST00000397801.1	+	22	3391	c.3199G>A	c.(3199-3201)Gtg>Atg	p.V1067M	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000543966.1_Intron|ROBO3_ENST00000538940.1_Missense_Mutation_p.V1045M	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1067					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GGGAGGCAAAGTGAAGCTTCT	0.582													9	14					0	0	1	0	0	A	124748211	G	A	124748211	3	1	48	1	0	0	0	0	1	0	0	0	13566	1029	36	3	3285	3	ROBO3	11	124748211	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	258548	124748211	10258305	2761	7155										
ROBO4	54538	broad.mit.edu	37	chr11	124763776	124763776	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggcccaggtgcaccctaGctcggcgccggcggtggata	16	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124763776G>T	ENST00000306534.3	-	9	1969	c.1484C>A	c.(1483-1485)gCt>gAt	p.A495D	ROBO4_ENST00000533054.1_Missense_Mutation_p.A350D	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	495					angiogenesis|cell differentiation	integral to membrane	receptor activity	p.A495D(1)		NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GTGCACCCTAGCTCGGCGCCG	0.632													10	15					3.86212e-05	4.21111e-05	1	1	0	T	124763776	G	T	124763776	3	4	48	1	0	0	0	0	1	0	0	0	13567	971	34	5	1579	5	ROBO4	11	124763776	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	15565	124763776	10242740	2762	7156										
HEPACAM	220296	broad.mit.edu	37	chr11	124793762	124793762	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggggacaggagcattctcGagtcattgaggaggggcttg	18	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124793762G>A	ENST00000298251.4	-	3	977	c.572C>T	c.(571-573)tCg>tTg	p.S191L		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	191	Ig-like C2-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GAGCATTCTCGAGTCATTGAG	0.582													18	28					0	0	1	0	0	A	124793762	G	A	124793762	3	1	48	1	0	0	0	0	1	0	0	0	7092	1059	37	1	698	1	HEPACAM	11	124793762	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29986	124793762	10212754	2763	7157										
CCDC15	80071	broad.mit.edu	37	chr11	124824652	124824652	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggaagtatggcccgaaaGaaacctcgaaatacctcaag	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124824652G>T	ENST00000529051.1	+	2	283	c.24G>T	c.(22-24)aaG>aaT	p.K8N	CCDC15_ENST00000344762.5_Missense_Mutation_p.K8N			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	8						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		TGGCCCGAAAGAAACCTCGAA	0.463													56	94					5.2118e-15	6.84239e-15	1	1	0	T	124824652	G	T	124824652	3	4	48	1	0	0	0	0	1	0	0	0	2802	933	33	2	26	2	CCDC15	11	124824652	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30890	124824652	10181864	2764	7158										
CCDC15	80071	broad.mit.edu	37	chr11	124910539	124910539	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtgatgtccctgggggtAattcaactcttcgagtcgca	11	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:124910539A>G	ENST00000529051.1	+	16	3080	c.2821A>G	c.(2821-2823)Aat>Gat	p.N941D	CCDC15_ENST00000530061.1_3'UTR|CCDC15_ENST00000344762.5_Missense_Mutation_p.N930D			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	930						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CCCTGGGGGTAATTCAACTCT	0.368													7	11					0	0	1	0	0	G	124910539	A	G	124910539	3	3	48	1	0	0	0	0	1	0	0	0	2802	362	13	4	2846	4	CCDC15	11	124910539	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	85887	124910539	10095977	2765	7159										
PUS3	83480	broad.mit.edu	37	chr11	125763958	125763958	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgacagagggcttaacatTtccccattctgtcattccat	6	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:125763958T>C	ENST00000227474.3	-	4	1265	c.1168A>G	c.(1168-1170)Aat>Gat	p.N390D	PUS3_ENST00000530811.1_Missense_Mutation_p.N390D|HYLS1_ENST00000356438.3_Intron|HYLS1_ENST00000526028.1_Intron|HYLS1_ENST00000425380.2_Intron	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597.3	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	390						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		GGCTTAACATTTCCCCATTCT	0.458													25	53					0	0	1	0	0	C	125763958	T	C	125763958	3	2	48	1	0	0	0	0	1	0	0	0	12883	1841	64	4	281	4	PUS3	11	125763958	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	853419	125763958	9242558	2766	7160										
FOXRED1	55572	broad.mit.edu	37	chr11	126141541	126141541	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgagtgctagtggtggaaCgggaccacacggtgaggtct	16	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:126141541C>T	ENST00000263578.5	+	2	369	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W	FOXRED1_ENST00000534011.1_Intron|FOXRED1_ENST00000532125.1_Missense_Mutation_p.R85W|FOXRED1_ENST00000442061.2_Intron	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	99						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		AGTGGTGGAACGGGACCACAC	0.547													18	46					0	0	1	0	0	T	126141541	C	T	126141541	3	4	48	1	0	0	0	0	1	0	0	0	6066	527	19	1	301	1	FOXRED1	11	126141541	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	377583	126141541	8864975	2767	7161										
ST3GAL4	6484	broad.mit.edu	37	chr11	126279209	126279209	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccctcatctgggatgtcaAtcctaaacagattcggattc	7	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:126279209A>C	ENST00000526727.1	+	8	1048	c.674A>C	c.(673-675)aAt>aCt	p.N225T	ST3GAL4_ENST00000532243.1_Missense_Mutation_p.N224T|ST3GAL4_ENST00000449406.2_Missense_Mutation_p.N214T|ST3GAL4_ENST00000444328.2_Missense_Mutation_p.N225T|ST3GAL4_ENST00000392669.2_Missense_Mutation_p.N225T|ST3GAL4_ENST00000534457.1_Missense_Mutation_p.N220T|ST3GAL4_ENST00000534083.1_Missense_Mutation_p.N225T|ST3GAL4_ENST00000227495.6_Missense_Mutation_p.N221T|ST3GAL4_ENST00000356132.4_Missense_Mutation_p.N231T|ST3GAL4_ENST00000530591.1_Missense_Mutation_p.N221T			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	225					post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		TGGGATGTCAATCCTAAACAG	0.517													49	101					0	0	1	0	0	C	126279209	A	C	126279209	3	2	48	1	0	0	0	0	1	0	0	0	15272	101	4	4	692	4	ST3GAL4	11	126279209	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	137668	126279209	8727307	2768	7162										
ARHGAP32	9743	broad.mit.edu	37	chr11	128839659	128839659	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttctgccactgagagaaGtccagttttcccaggatctg	9	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:128839659G>T	ENST00000310343.9	-	22	5406	c.5407C>A	c.(5407-5409)Ctt>Att	p.L1803I	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.L1454I|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.L1454I|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1803	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						ACTGAGAGAAGTCCAGTTTTC	0.547													18	97					6.94344e-10	8.4399e-10	1	1	0	T	128839659	G	T	128839659	3	4	48	1	0	0	0	0	1	0	0	0	878	1029	36	5	860	5	ARHGAP32	11	128839659	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2560450	128839659	6166857	2769	7163										
BARX2	8538	broad.mit.edu	37	chr11	129246058	129246058	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgattactttgagaaactttCcctctactccgtgtgcccgt	7	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:129246058C>T	ENST00000281437.4	+	1	224	c.128C>T	c.(127-129)tCc>tTc	p.S43F		NM_003658.4	NP_003649.2	Q9UMQ3	BARX2_HUMAN	BARX homeobox 2	43										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		GAGAAACTTTCCCTCTACTCC	0.582											OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	179					0	0	1	0	0	T	129246058	C	T	129246058	3	4	48	1	0	0	0	0	1	0	0	0	1314	855	30	3	130	3	BARX2	11	129246058	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	406399	129246058	5760458	2770	7164										
PRDM10	56980	broad.mit.edu	37	chr11	129784708	129784708	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtaatccccttgtggcgttCggtagtctgtcgttaaggtc	13	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:129784708C>T	ENST00000358825.5	-	18	2975	c.2744G>A	c.(2743-2745)cGa>cAa	p.R915Q	PRDM10_ENST00000304538.6_Missense_Mutation_p.R825Q|PRDM10_ENST00000360871.3_Missense_Mutation_p.R911Q|PRDM10_ENST00000528746.1_Missense_Mutation_p.R885Q|PRDM10_ENST00000526082.1_Missense_Mutation_p.R829Q|PRDM10_ENST00000423662.2_Missense_Mutation_p.R829Q	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	915	Thr-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TTGTGGCGTTCGGTAGTCTGT	0.547													96	168					0	0	1	0	0	T	129784708	C	T	129784708	3	4	48	1	0	0	0	0	1	0	0	0	12502	884	31	1	758	1	PRDM10	11	129784708	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	538650	129784708	5221808	2771	7165										
IGSF9B	22997	broad.mit.edu	37	chr11	133790722	133790722	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctgctgaggtacccataAtactggccatggtggaaggg	14	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:133790722A>C	ENST00000321016.8	-	18	3128	c.2898T>G	c.(2896-2898)taT>taG	p.Y966*	IGSF9B_ENST00000533871.2_Nonsense_Mutation_p.Y966*			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	966	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GGTACCCATAATACTGGCCAT	0.721													11	27					0	0	1	0	0	C	133790722	A	C	133790722	4	2	48	1	0	0	0	0	0	1	0	0	7649	108	4	4	1159	4	IGSF9B	11	133790722	Nonsense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	4006014	133790722	1215794	2772	7166										
NCAPD3	23310	broad.mit.edu	37	chr11	134073715	134073715	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctttaagaacttctgatgCtccaaggagagggtgttatc	11	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:134073715C>T	ENST00000534548.2	-	11	1366	c.1302G>A	c.(1300-1302)gaG>gaA	p.E434E		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	434					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		ACTTCTGATGCTCCAAGGAGA	0.468													17	80					0	0	1	0	0	T	134073715	C	T	134073715	2	4	48	1	0	0	0	0	0	0	0	1	10252	796	28	3		3	NCAPD3	11	134073715	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	282993	134073715	932801	2773	7167										
ACAD8	27034	broad.mit.edu	37	chr11	134127029	134127029	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggcagcccagctaggcttCggaggggtctacatacaaac	12	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:134127029C>T	ENST00000281182.4	+	3	364	c.258C>T	c.(256-258)ttC>ttT	p.F86F	ACAD8_ENST00000543332.1_Intron|ACAD8_ENST00000524547.1_Intron|ACAD8_ENST00000537423.1_Silent_p.F9F|ACAD8_ENST00000374752.4_Intron	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	86					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		AGCTAGGCTTCGGAGGGGTCT	0.547													24	62					0	0	1	0	0	T	134127029	C	T	134127029	2	4	48	1	0	0	0	0	0	0	0	1	110	883	31	1		1	ACAD8	11	134127029	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53314	134127029	879487	2774	7168										
GLB1L3	112937	broad.mit.edu	37	chr11	134147599	134147599	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccgccccctccaggtttaAttggtctcatctgacccctc	7	18	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:134147599A>C	ENST00000389887.5	+	3	2651	c.155A>C	c.(154-156)aAt>aCt	p.N52T	GLB1L3_ENST00000431683.2_Missense_Mutation_p.N52T			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	52					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TCCAGGTTTAATTGGTCTCAT	0.562													4	9					0	0	1	0	0	C	134147599	A	C	134147599	3	2	48	1	0	0	0	0	1	0	0	0	6471	101	4	4	165	4	GLB1L3	11	134147599	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	20570	134147599	858917	2775	7169										
GLB1L3	112937	broad.mit.edu	37	chr11	134183838	134183838	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccatctgcatctgcaggaaTaactggatctgtcagcatca	8	12	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr11:134183838T>C	ENST00000431683.2	+	17	1583	c.1583T>C	c.(1582-1584)aTa>aCa	p.I528T		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	528					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TCTGCAGGAATAACTGGATCT	0.468													11	14					0	0	1	0	0	C	134183838	T	C	134183838	3	2	48	1	0	0	0	0	1	0	0	0	6471	1406	49	4	1649	4	GLB1L3	11	134183838	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	36239	134183838	822678	2776	7170										
WNK1	65125	broad.mit.edu	37	chr12	922930	922930	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaatccacagtaaaaggaaaGaagtgcattgttttggtgac	11	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:922930G>A	ENST00000537687.1	+	2	1525	c.882G>A	c.(880-882)aaG>aaA	p.K294K	WNK1_ENST00000530271.2_Silent_p.K294K|WNK1_ENST00000447667.2_Silent_p.K294K|WNK1_ENST00000315939.6_Silent_p.K294K|WNK1_ENST00000535572.1_Silent_p.K294K	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	294	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TAAAAGGAAAGAAGTGCATTG	0.358													4	34					0	0	1	0	0	A	922930	G	A	922930	2	1	48	1	0	0	0	0	0	0	0	1	17436	933	33	3		3	WNK1	12	922930	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		922930	132928965	2777	7171										
WNT5B	81029	broad.mit.edu	37	chr12	1740581	1740581	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagctgggctcagcttctgAcagacgccaactcctggtgg	12	14	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:1740581A>G	ENST00000397196.2	+	2	293	c.61A>G	c.(61-63)Aca>Gca	p.T21A	WNT5B_ENST00000310594.3_Missense_Mutation_p.T21A|WNT5B_ENST00000537031.1_Missense_Mutation_p.T21A|WNT5B_ENST00000542408.1_Missense_Mutation_p.T21A	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	21					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			TCAGCTTCTGACAGACGCCAA	0.642													28	57					0	0	1	0	0	G	1740581	A	G	1740581	3	3	48	1	0	0	0	0	1	0	0	0	17451	275	10	4	63	4	WNT5B	12	1740581	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	817651	1740581	132111314	2778	7172										
CACNA2D4	93589	broad.mit.edu	37	chr12	1909191	1909191	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccctctgtcgtaccaggaGccccagacactccactccag	8	19	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:1909191G>A	ENST00000382722.5	-	33	3311	c.2949C>T	c.(2947-2949)ggC>ggT	p.G983G	CACNA2D4_ENST00000585708.1_Silent_p.G919G|CACNA2D4_ENST00000538450.1_Silent_p.G113G|CACNA2D4_ENST00000538027.2_Silent_p.G128G|CACNA2D4_ENST00000588077.1_Silent_p.G919G|CACNA2D4_ENST00000587995.1_Silent_p.G958G|CACNA2D4_ENST00000586184.1_Silent_p.G983G	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	983						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CGTACCAGGAGCCCCAGACAC	0.592													7	16					0	0	1	0	0	A	1909191	G	A	1909191	2	1	48	1	0	0	0	0	0	0	0	1	2569	958	34	3		3	CACNA2D4	12	1909191	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	168610	1909191	131942704	2779	7173										
CACNA1C	775	broad.mit.edu	37	chr12	2676775	2676775	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggccctgttcacggcagaGatgctcctgaagatgtacag	12	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:2676775G>A	ENST00000399655.1	+	13	1975	c.1710G>A	c.(1708-1710)gaG>gaA	p.E570E	CACNA1C_ENST00000399603.1_Silent_p.E570E|CACNA1C_ENST00000399617.1_Silent_p.E570E|CACNA1C_ENST00000399637.1_Silent_p.E570E|CACNA1C_ENST00000406454.3_Silent_p.E570E|CACNA1C_ENST00000399606.1_Silent_p.E570E|CACNA1C_ENST00000402845.3_Silent_p.E570E|CACNA1C_ENST00000399649.1_Silent_p.E570E|CACNA1C_ENST00000335762.5_Silent_p.E595E|CACNA1C_ENST00000347598.4_Silent_p.E570E|CACNA1C_ENST00000399638.1_Silent_p.E570E|CACNA1C_ENST00000399591.1_Silent_p.E570E|CACNA1C_ENST00000399621.1_Silent_p.E570E|CACNA1C_ENST00000327702.7_Silent_p.E570E|CACNA1C_ENST00000399595.1_Silent_p.E570E|CACNA1C_ENST00000399634.1_Silent_p.E570E|CACNA1C_ENST00000344100.3_Silent_p.E570E|CACNA1C_ENST00000480911.1_Silent_p.E570E|CACNA1C_ENST00000399601.1_Silent_p.E570E|CACNA1C_ENST00000399641.1_Silent_p.E570E|CACNA1C_ENST00000399644.1_Silent_p.E570E|CACNA1C_ENST00000399629.1_Silent_p.E570E|CACNA1C_ENST00000399597.1_Silent_p.E570E	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	570					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCACGGCAGAGATGCTCCTGA	0.622													4	12					0	0	1	0	0	A	2676775	G	A	2676775	2	1	48	1	0	0	0	0	0	0	0	1	2558	933	33	3		3	CACNA1C	12	2676775	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	767584	2676775	131175120	2780	7174										
CACNA1C	775	broad.mit.edu	37	chr12	2763047	2763047	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgatgctgttcttcatctAcgcggtgatcgggatgcagg	14	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:2763047A>G	ENST00000399655.1	+	33	4386	c.4121A>G	c.(4120-4122)tAc>tGc	p.Y1374C	CACNA1C_ENST00000399603.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399617.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399637.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000406454.3_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399606.1_Missense_Mutation_p.Y1394C|CACNA1C_ENST00000402845.3_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399649.1_Missense_Mutation_p.Y1361C|CACNA1C_ENST00000335762.5_Missense_Mutation_p.Y1399C|CACNA1C_ENST00000347598.4_Missense_Mutation_p.Y1422C|CACNA1C_ENST00000399638.1_Missense_Mutation_p.Y1402C|CACNA1C_ENST00000399591.1_Missense_Mutation_p.Y1363C|CACNA1C_ENST00000399621.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000327702.7_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399595.1_Missense_Mutation_p.Y1363C|CACNA1C_ENST00000399634.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000344100.3_Missense_Mutation_p.Y1396C|CACNA1C_ENST00000399601.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399641.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399644.1_Missense_Mutation_p.Y1374C|CACNA1C_ENST00000399629.1_Missense_Mutation_p.Y1391C|CACNA1C_ENST00000399597.1_Missense_Mutation_p.Y1374C	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1422					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTCTTCATCTACGCGGTGATC	0.627													8	21					0	0	1	0	0	G	2763047	A	G	2763047	3	3	48	1	0	0	0	0	1	0	0	0	2558	391	14	4	4577	4	CACNA1C	12	2763047	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	86272	2763047	131088848	2781	7175										
TULP3	7289	broad.mit.edu	37	chr12	3018701	3018701	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttttttaacagtgtcttCcatgaagaaatgatgaagat	7	4	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:3018701C>T	ENST00000448120.2	+	2	99	c.48C>T	c.(46-48)ttC>ttT	p.F16F	TULP3_ENST00000397132.2_Silent_p.F16F	NM_003324.4	NP_003315.2	O75386	TULP3_HUMAN	tubby like protein 3	16					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|large_intestine(4)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			ACAGTGTCTTCCATGAAGAAA	0.358													32	61					0	0	1	0	0	T	3018701	C	T	3018701	2	4	48	1	0	0	0	0	0	0	0	1	16836	854	30	3		3	TULP3	12	3018701	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	255654	3018701	130833194	2782	7176										
TULP3	7289	broad.mit.edu	37	chr12	3031488	3031488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatgctccatcagtaagctCctctgttgtggaagaagatg	10	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:3031488C>T	ENST00000448120.2	+	4	365	c.314C>T	c.(313-315)tCc>tTc	p.S105F	TULP3_ENST00000397132.2_Missense_Mutation_p.S105F	NM_003324.4	NP_003315.2	O75386	TULP3_HUMAN	tubby like protein 3	105					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|large_intestine(4)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TCAGTAAGCTCCTCTGTTGTG	0.443													33	59					0	0	1	0	0	T	3031488	C	T	3031488	3	4	48	1	0	0	0	0	1	0	0	0	16836	855	30	3	328	3	TULP3	12	3031488	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12787	3031488	130820407	2783	7177										
CCND2	894	broad.mit.edu	37	chr12	4398043	4398043	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtacccaccgtcgatgatcGcaactggaagtgtgggagca	13	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:4398043G>A	ENST00000261254.3	+	4	876	c.607G>A	c.(607-609)Gca>Aca	p.A203T		NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	203					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			GTCGATGATCGCAACTGGAAG	0.547			T	IGL@	"NHL,CLL"								28	134					0	0	1	0	0	A	4398043	G	A	4398043	3	1	48	1	0	0	0	0	1	0	0	0	2939	1087	38	1	621	1	CCND2	12	4398043	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1366555	4398043	129453852	2784	7178										
DYRK4	8798	broad.mit.edu	37	chr12	4708218	4708218	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacttgtatgagttgatgaaGaataacaactttcaaggctt	8	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:4708218G>T	ENST00000540757.2	+	7	745	c.585G>T	c.(583-585)aaG>aaT	p.K195N	DYRK4_ENST00000543431.1_Missense_Mutation_p.K195N|DYRK4_ENST00000010132.5_Missense_Mutation_p.K195N	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	195	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			AGTTGATGAAGAATAACAACT	0.393													26	50					4.72057e-08	5.51616e-08	1	1	0	T	4708218	G	T	4708218	3	4	48	1	0	0	0	0	1	0	0	0	4884	933	33	2	603	2	DYRK4	12	4708218	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	310175	4708218	129143677	2785	7179										
KCNA6	3742	broad.mit.edu	37	chr12	4920773	4920773	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacatcgggcctatgcagaGaaaagaatgctcacggaggt	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:4920773G>T	ENST00000433855.1	+	1	2432	c.1566G>T	c.(1564-1566)gaG>gaT	p.E522D	KCNA6_ENST00000280684.3_Missense_Mutation_p.E522D	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	522						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CCTATGCAGAGAAAAGAATGC	0.567										HNSCC(72;0.22)			33	73					1.04594e-18	1.41924e-18	1	1	0	T	4920773	G	T	4920773	3	4	48	1	0	0	0	0	1	0	0	0	8050	933	33	2	1568	2	KCNA6	12	4920773	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	212555	4920773	128931122	2786	7180										
KCNA1	3736	broad.mit.edu	37	chr12	5021796	5021796	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaactatttctaccaccgaGaaactgagggggaagagcag	11	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:5021796G>T	ENST00000382545.3	+	2	2359	c.1252G>T	c.(1252-1254)Gaa>Taa	p.E418*	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	418					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTACCACCGAGAAACTGAGGG	0.527													73	170					1.93348e-29	2.75448e-29	1	1	0	T	5021796	G	T	5021796	4	4	48	1	0	0	0	0	0	1	0	0	8044	943	33	2	1254	2	KCNA1	12	5021796	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	101023	5021796	128830099	2787	7181										
KCNA5	3741	broad.mit.edu	37	chr12	5154876	5154876	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgtctccaacttcaactaCttctaccaccgggaaacgga	6	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:5154876C>A	ENST00000252321.3	+	1	1792	c.1563C>A	c.(1561-1563)taC>taA	p.Y521*		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	521						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						ACTTCAACTACTTCTACCACC	0.627													26	51					2.79863e-10	3.42475e-10	1	1	0	A	5154876	C	A	5154876	4	1	48	1	0	0	0	0	0	1	0	0	8049	576	20	5	1565	5	KCNA5	12	5154876	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	133080	5154876	128697019	2788	7182										
VWF	7450	broad.mit.edu	37	chr12	6125981	6125981	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttcatcaaaataagaagcTgggaaactggaggagccatc	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:6125981T>G	ENST00000261405.5	-	29	5363	c.5109A>C	c.(5107-5109)ccA>ccC	p.P1703P		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1703	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AATAAGAAGCTGGGAAACTGG	0.522													30	102					0	0	1	0	0	G	6125981	T	G	6125981	2	3	48	1	0	0	0	0	0	0	0	1	17305	1567	55	4		4	VWF	12	6125981	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	971105	6125981	127725914	2789	7183										
PLEKHG6	55200	broad.mit.edu	37	chr12	6427545	6427545	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcacaccagacagctgctgCtggaggggcctgtgcgagtg	16	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:6427545C>T	ENST00000449001.2	+	10	1632	c.1138C>T	c.(1138-1140)Ctg>Ttg	p.L380L	PLEKHG6_ENST00000011684.7_Silent_p.L412L|PLEKHG6_ENST00000536531.1_Silent_p.L412L|PLEKHG6_ENST00000396988.3_Silent_p.L412L	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	412					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						ACAGCTGCTGCTGGAGGGGCC	0.642													26	39					0	0	1	0	0	T	6427545	C	T	6427545	2	4	48	1	0	0	0	0	0	0	0	1	12121	796	28	3		3	PLEKHG6	12	6427545	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	301564	6427545	127424350	2790	7184										
CHD4	1108	broad.mit.edu	37	chr12	6701195	6701195	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcattgagtgcttcaaaatTtcgagtgaggatgtacttgt	12	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:6701195T>G	ENST00000309577.6	-	20	3140	c.2977A>C	c.(2977-2979)Aat>Cat	p.N993H	CHD4_ENST00000544040.1_Missense_Mutation_p.N986H|CHD4_ENST00000544484.1_Missense_Mutation_p.N990H|CHD4_ENST00000357008.2_Missense_Mutation_p.N993H			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	993					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCTTCAAAATTTCGAGTGAGG	0.458													36	66					0	0	1	0	0	G	6701195	T	G	6701195	3	3	48	1	0	0	0	0	1	0	0	0	3349	1841	64	4	2845	4	CHD4	12	6701195	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	273650	6701195	127150700	2791	7185										
CHD4	1108	broad.mit.edu	37	chr12	6709138	6709138	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggatctcctcaccctccGaattgtcctctttagcttcc	5	17	3	0	rs147387698		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:6709138G>T	ENST00000309577.6	-	10	1446	c.1283C>A	c.(1282-1284)tCg>tAg	p.S428*	CHD4_ENST00000544040.1_Nonsense_Mutation_p.S421*|CHD4_ENST00000544484.1_Nonsense_Mutation_p.S425*|CHD4_ENST00000357008.2_Nonsense_Mutation_p.S428*			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	428					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTCACCCTCCGAATTGTCCTC	0.547													123	183					1.30956e-91	1.90374e-91	1	1	0	T	6709138	G	T	6709138	4	4	48	1	0	0	0	0	0	1	0	0	3349	1059	37	2	4579	2	CHD4	12	6709138	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7943	6709138	127142757	2792	7186										
EMG1	10436	broad.mit.edu	37	chr12	7084399	7084399	+	RNA	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttactttaggtaattaaGaatccagtatcagatcactt	5	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7084399G>T	ENST00000546220.1	+	0	510				U47924.19_ENST00000564245.1_RNA|U47924.28_ENST00000261406.6_lincRNA			Q92979	NEP1_HUMAN	EMG1 N1-specific pseudouridine methyltransferase						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										AGGTAATTAAGAATCCAGTAT	0.433													3	21					0.004672	0.00483628	1	1	0	T	7084399	G	T	7084399	1	4	48	0	1	0	0	0	0	0	0	0	5118	933	33	2		2	EMG1	12	7084399	RNA	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	375261	7084399	126767496	2793	7187										
LPCAT3	10162	broad.mit.edu	37	chr12	7086403	7086403	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggaagaagatgtggccaaGgaaatagatggatttataca	12	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7086403G>A	ENST00000261407.4	-	12	1454	c.1369C>T	c.(1369-1371)Ctt>Ttt	p.L457F	U47924.19_ENST00000564245.1_RNA|LPCAT3_ENST00000535021.1_5'UTR	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	457					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						ATGTGGCCAAGGAAATAGATG	0.443													23	40					0	0	1	0	0	A	7086403	G	A	7086403	3	1	48	1	0	0	0	0	1	0	0	0	8956	1000	35	3	98	3	LPCAT3	12	7086403	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2004	7086403	126765492	2794	7188										
C1R	715	broad.mit.edu	37	chr12	7188438	7188438	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcgcttcgtgttccttggGatacagggtgtgggcagctg	16	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7188438G>A	ENST00000542285.1	-	11	1509	c.1360C>T	c.(1360-1362)Ccc>Tcc	p.P454S				P00736	C1R_HUMAN	complement component 1, r subcomponent	506					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGTTCCTTGGGATACAGGGTG	0.612													7	56					0	0	1	0	0	A	7188438	G	A	7188438	3	1	48	1	0	0	0	0	1	0	0	0	1985	1174	41	3	605	3	C1R	12	7188438	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	102035	7188438	126663457	2795	7189										
CLSTN3	9746	broad.mit.edu	37	chr12	7302202	7302202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggggatgacctggatcccGagcgggaaagcctgctcctg	16	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7302202G>A	ENST00000537408.1	+	13	2732	c.2194G>A	c.(2194-2196)Gag>Aag	p.E732K	CLSTN3_ENST00000266546.6_Missense_Mutation_p.E720K			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	720					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CCTGGATCCCGAGCGGGAAAG	0.572													15	41					0	0	1	0	0	A	7302202	G	A	7302202	3	1	48	1	0	0	0	0	1	0	0	0	3586	1059	37	1	2212	1	CLSTN3	12	7302202	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	113764	7302202	126549693	2796	7190										
CD163L1	283316	broad.mit.edu	37	chr12	7520728	7520728	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaactcggcaccacgtgaGaaatagaataaacagaacca	8	10	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7520728G>T	ENST00000313599.3	-	17	4195	c.4138C>A	c.(4138-4140)Ctc>Atc	p.L1380I	CD163L1_ENST00000396630.1_Missense_Mutation_p.L1380I|CD163L1_ENST00000416109.2_Missense_Mutation_p.L1390I			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1380						extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CACCACGTGAGAAATAGAATA	0.408													25	64					1.04121e-07	1.21041e-07	1	1	0	T	7520728	G	T	7520728	3	4	48	1	0	0	0	0	1	0	0	0	2990	942	33	2	235	2	CD163L1	12	7520728	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	218526	7520728	126331167	2797	7191										
CD163	9332	broad.mit.edu	37	chr12	7639348	7639348	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgccccaggagccctcatgAtagatctctactctcccagc	8	16	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7639348A>C	ENST00000359156.4	-	10	2407	c.2205T>G	c.(2203-2205)taT>taG	p.Y735*	CD163_ENST00000432237.2_Nonsense_Mutation_p.Y735*|CD163_ENST00000396620.3_Nonsense_Mutation_p.Y768*|CD163_ENST00000541972.1_Nonsense_Mutation_p.Y723*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	735	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AGCCCTCATGATAGATCTCTA	0.512													41	104					0	0	1	0	0	C	7639348	A	C	7639348	4	2	48	1	0	0	0	0	0	1	0	0	2989	340	12	4	1293	4	CD163	12	7639348	Nonsense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	118620	7639348	126212547	2798	7192										
CD163	9332	broad.mit.edu	37	chr12	7649418	7649418	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttaacttaccagaacatgTcacgccagcatcttcattgt	5	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7649418T>C	ENST00000359156.4	-	5	1292	c.1090A>G	c.(1090-1092)Aca>Gca	p.T364A	CD163_ENST00000432237.2_Missense_Mutation_p.T364A|CD163_ENST00000396620.3_Missense_Mutation_p.T364A|CD163_ENST00000541972.1_Missense_Mutation_p.T352A	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	364	SRCR 3.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CCAGAACATGTCACGCCAGCA	0.423													10	37					0	0	1	0	0	C	7649418	T	C	7649418	3	2	48	1	0	0	0	0	1	0	0	0	2989	1667	58	4	2428	4	CD163	12	7649418	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	10070	7649418	126202477	2799	7193										
APOBEC1	339	broad.mit.edu	37	chr12	7803651	7803651	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcagctccagtgcgtacaAcatcatccacagaggtgggt	12	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7803651A>G	ENST00000229304.4	-	4	549	c.529T>C	c.(529-531)Ttg>Ctg	p.L177L		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	177					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						AGTGCGTACAACATCATCCAC	0.443													12	114					0	0	1	0	0	G	7803651	A	G	7803651	2	3	48	1	0	0	0	0	0	0	0	1	784	40	2	4		4	APOBEC1	12	7803651	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	154233	7803651	126048244	2800	7194										
GDF3	9573	broad.mit.edu	37	chr12	7842753	7842753	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccaacccaggtcccggaaGttaatgaatagctggtgacg	12	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:7842753G>T	ENST00000329913.3	-	2	863	c.816C>A	c.(814-816)aaC>aaA	p.N272K		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	272					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						GGTCCCGGAAGTTAATGAATA	0.532													32	58					1.61788e-16	2.15322e-16	1	1	0	T	7842753	G	T	7842753	3	4	48	1	0	0	0	0	1	0	0	0	6356	1020	36	5	282	5	GDF3	12	7842753	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	39102	7842753	126009142	2801	7195										
CLEC4A	50856	broad.mit.edu	37	chr12	8276482	8276482	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctcttcccattatgacttCggaaatcacttatgctgaag	6	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:8276482C>T	ENST00000229332.5	+	1	255	c.8C>T	c.(7-9)tCg>tTg	p.S3L	CLEC4A_ENST00000360500.3_Missense_Mutation_p.S3L|CLEC4A_ENST00000352620.3_Missense_Mutation_p.S3L|CLEC4A_ENST00000345999.3_Missense_Mutation_p.S3L	NM_016184.3|NM_194447.2|NM_194450.2	NP_057268.1|NP_919429.2|NP_919432.1	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A	3					cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)	11				Kidney(36;0.0915)		ATTATGACTTCGGAAATCACT	0.378													17	23					0	0	1	0	0	T	8276482	C	T	8276482	3	4	48	1	0	0	0	0	1	0	0	0	3535	893	31	1	10	1	CLEC4A	12	8276482	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	433729	8276482	125575413	2802	7196										
ZNF705A	440077	broad.mit.edu	37	chr12	8329731	8329731	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcaaacagtgtggaaaatCtcttcgtaatcttttctccc	6	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:8329731C>A	ENST00000359286.4	+	5	544	c.455C>A	c.(454-456)tCt>tAt	p.S152Y		NM_001004328.2|NM_001278713.1	NP_001004328.1|NP_001265642.1	Q6ZN79	Z705A_HUMAN	zinc finger protein 705A	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|skin(3)|stomach(4)	18				Kidney(36;0.0877)		TGTGGAAAATCTCTTCGTAAT	0.358													13	170					0.000151284	0.00016287	1	1	0	A	8329731	C	A	8329731	3	1	48	1	0	0	0	0	1	0	0	0	18163	913	32	2	473	2	ZNF705A	12	8329731	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53249	8329731	125522164	2803	7197										
CLEC4D	338339	broad.mit.edu	37	chr12	8667888	8667888	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttattgctgtagttttcatcTtacttctcagtgtctgtttt	6	7	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:8667888T>G	ENST00000299665.2	+	2	278	c.85T>G	c.(85-87)Tta>Gta	p.L29V		NM_080387.4	NP_525126.2	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	29					innate immune response	integral to membrane	sugar binding			large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Lung SC(5;0.184)					AGTTTTCATCTTACTTCTCAG	0.373													4	58					0	0	1	0	0	G	8667888	T	G	8667888	3	3	48	1	0	0	0	0	1	0	0	0	3537	1606	56	4	91	4	CLEC4D	12	8667888	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	338157	8667888	125184007	2804	7198										
A2ML1	144568	broad.mit.edu	37	chr12	8995860	8995860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcatccaccggctaaacgGccccttgaaatgtggccagc	11	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:8995860G>A	ENST00000299698.7	+	12	1559	c.1379G>A	c.(1378-1380)gGc>gAc	p.G460D		NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	304						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						CGGCTAAACGGCCCCTTGAAA	0.552													38	71					0	0	1	0	0	A	8995860	G	A	8995860	3	1	48	1	0	0	0	0	1	0	0	0	5	1203	42	3	1425	3	A2ML1	12	8995860	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	327972	8995860	124856035	2805	7199										
A2M	2	broad.mit.edu	37	chr12	9220799	9220799	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttgctgcaaggagcattgTactcagcaattgcaaactca	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:9220799T>C	ENST00000318602.7	-	35	4695	c.4388A>G	c.(4387-4389)tAc>tGc	p.Y1463C		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	1463					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	AGGAGCATTGTACTCAGCAAT	0.428													8	11					0	0	1	0	0	C	9220799	T	C	9220799	3	2	48	1	0	0	0	0	1	0	0	0	4	1638	57	4	44	4	A2M	12	9220799	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	224939	9220799	124631096	2806	7200										
CLEC12A	160364	broad.mit.edu	37	chr12	10124262	10124262	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgagatggaaaaaatcccaGaaattggcaaatttggggaa	12	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:10124262G>T	ENST00000304361.4	+	1	249	c.67G>T	c.(67-69)Gaa>Taa	p.E23*	CLEC12A_ENST00000355690.4_Nonsense_Mutation_p.E33*|CLEC12A_ENST00000434319.2_Nonsense_Mutation_p.E23*|CLEC12A_ENST00000350667.4_Nonsense_Mutation_p.E23*	NM_138337.5|NM_201623.3	NP_612210.4|NP_963917.2	Q5QGZ9	CL12A_HUMAN	C-type lectin domain family 12, member A	23						integral to membrane|plasma membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	16						AAAAATCCCAGAAATTGGCAA	0.323													15	26					2.23348e-06	2.50077e-06	1	1	0	T	10124262	G	T	10124262	4	4	48	1	0	0	0	0	0	1	0	0	3520	943	33	2	69	2	CLEC12A	12	10124262	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	903463	10124262	123727633	2807	7201										
KLRC3	3823	broad.mit.edu	37	chr12	10569349	10569349	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaatccatgaggaaggtaaAatgctggccagaaatttcta	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:10569349A>C	ENST00000396439.2	-	5	548	c.504T>G	c.(502-504)atT>atG	p.I168M	NKG2-E_ENST00000539033.1_Missense_Mutation_p.I168M|KLRC3_ENST00000381903.2_Missense_Mutation_p.I168M|KLRC3_ENST00000381904.2_Missense_Mutation_p.I168M	NM_002261.2	NP_002252.2			killer cell lectin-like receptor subfamily C, member 3											large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						AGGAAGGTAAAATGCTGGCCA	0.299													4	25					0	0	1	0	0	C	10569349	A	C	10569349	3	2	48	1	0	0	0	0	1	0	0	0	8459	10	1	4	326	4	KLRC3	12	10569349	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	445087	10569349	123282546	2808	7202										
TAS2R8	50836	broad.mit.edu	37	chr12	10959316	10959316	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtagttggcaaatgtccaGaaggtaaaaatgactatctg	10	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:10959316G>A	ENST00000240615.2	-	1	576	c.264C>T	c.(262-264)ttC>ttT	p.F88F		NM_023918.1	NP_076407.1	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	88					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CAAATGTCCAGAAGGTAAAAA	0.348													36	41					0	0	1	0	0	A	10959316	G	A	10959316	2	1	48	1	0	0	0	0	0	0	0	1	15643	933	33	3		3	TAS2R8	12	10959316	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	389967	10959316	122892579	2809	7203										
TAS2R9	50835	broad.mit.edu	37	chr12	10962679	10962679	+	Translation_Start_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctattgcacttggcatgccaGcaaagacttgtgatttttga	9	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:10962679G>T	ENST00000240691.2	-	0	88					NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9						sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TGGCATGCCAGCAAAGACTTG	0.368													15	39					7.93312e-07	8.98086e-07	1	1	0	T	10962679	G	T	10962679	1	4	48	1	0	0	0	0	0	0	0	0	15644	986	34	5		5	TAS2R9	12	10962679	Translation_Start_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3363	10962679	122889216	2810	7204										
TAS2R50	259296	broad.mit.edu	37	chr12	11139431	11139431	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaaaccattattagaattGaaaaaaaaatgtatagaaaa	4	2	0	3	rs79147066		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:11139431G>T	ENST00000506868.1	-	1	80	c.29C>A	c.(28-30)tCa>tAa	p.S10*	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176890.2	NP_795371.2	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	10					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.S10fs*25(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						TATTAGAATTGAAAAAAAAAT	0.318													16	42					4.7546e-09	5.67505e-09	1	1	0	T	11139431	G	T	11139431	4	4	48	1	0	0	0	0	0	1	0	0	15640	1294	45	2	874	2	TAS2R50	12	11139431	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	176752	11139431	122712464	2811	7205										
TAS2R20	259295	broad.mit.edu	37	chr12	11150374	11150374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttttgtctcttgacccagGcaatgaaatttatcagtgct	7	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:11150374G>A	ENST00000538986.1	-	1	100	c.101C>T	c.(100-102)gCc>gTc	p.A34V	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	34					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						CTTGACCCAGGCAATGAAATT	0.368													20	39					0	0	1	0	0	A	11150374	G	A	11150374	3	1	48	1	0	0	0	0	1	0	0	0	15627	1203	42	3	832	3	TAS2R20	12	11150374	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10943	11150374	122701521	2812	7206										
ETV6	2120	broad.mit.edu	37	chr12	12038927	12038927	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctactacaaactaaacattaTcaggaaggagccaggacaaa	7	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:12038927T>C	ENST00000396373.4	+	7	1494	c.1220T>C	c.(1219-1221)aTc>aCc	p.I407T		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	407						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTAAACATTATCAGGAAGGAG	0.423			T	"NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"	"congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"								35	88					0	0	1	0	0	C	12038927	T	C	12038927	3	2	48	1	0	0	0	0	1	0	0	0	5311	1435	50	4	1246	4	ETV6	12	12038927	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	888553	12038927	121812968	2813	7207										
LRP6	4040	broad.mit.edu	37	chr12	12300346	12300346	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggagatctgaatcagcccaAaagagcttgcccagcctgct	10	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:12300346A>C	ENST00000261349.4	-	15	3427	c.3351T>G	c.(3349-3351)ttT>ttG	p.F1117L	LRP6_ENST00000543091.1_Missense_Mutation_p.F1117L	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1117	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				AATCAGCCCAAAAGAGCTTGC	0.433													5	91					0	0	1	0	0	C	12300346	A	C	12300346	3	2	48	1	0	0	0	0	1	0	0	0	9006	11	1	4	1526	4	LRP6	12	12300346	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	261419	12300346	121551549	2814	7208										
LRP6	4040	broad.mit.edu	37	chr12	12317334	12317334	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccagagaaattcgtctgAtatctgctctccgtgaaaac	7	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:12317334A>C	ENST00000261349.4	-	9	2001	c.1925T>G	c.(1924-1926)aTc>aGc	p.I642S	LRP6_ENST00000543091.1_Missense_Mutation_p.I642S	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	642	Beta-propeller 3.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				AATTCGTCTGATATCTGCTCT	0.443													21	45					0	0	1	0	0	C	12317334	A	C	12317334	3	2	48	1	0	0	0	0	1	0	0	0	9006	333	12	4	2976	4	LRP6	12	12317334	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	16988	12317334	121534561	2815	7209										
MANSC1	54682	broad.mit.edu	37	chr12	12491458	12491458	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggttgtctagctgtttttCgagtgtcgaagatcatcaag	12	6	3	1	rs139772377	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:12491458C>T	ENST00000535902.1	-	3	823	c.260G>A	c.(259-261)cGa>cAa	p.R87Q	MANSC1_ENST00000396349.3_Missense_Mutation_p.R53Q|MANSC1_ENST00000545735.1_Missense_Mutation_p.R6Q			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	87	MANSC.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		AGCTGTTTTTCGAGTGTCGAA	0.403													12	77					0	0	1	0	0	T	12491458	C	T	12491458	3	4	48	1	0	0	0	0	1	0	0	0	9273	884	31	1	1043	1	MANSC1	12	12491458	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	174124	12491458	121360437	2816	7210										
DUSP16	80824	broad.mit.edu	37	chr12	12633209	12633209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcatgatgtaggcgatagCgatggtggcggagcgggaga	18	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:12633209C>T	ENST00000228862.2	-	6	1394	c.763G>A	c.(763-765)Gct>Act	p.A255T	DUSP16_ENST00000298573.4_3'UTR|DUSP16_ENST00000545864.1_Intron	NM_030640.2	NP_085143.1	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	255	Tyrosine-protein phosphatase.				inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(7)|kidney(2)|large_intestine(6)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(3)	26		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		TAGGCGATAGCGATGGTGGCG	0.458													45	85					0	0	1	0	0	T	12633209	C	T	12633209	3	4	48	1	0	0	0	0	1	0	0	0	4842	768	27	1	1242	1	DUSP16	12	12633209	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	141751	12633209	121218686	2817	7211										
WBP11	51729	broad.mit.edu	37	chr12	14947660	14947660	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaaggatagaaactgcccGagttggaggtctgttaaaaa	13	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:14947660G>A	ENST00000261167.2	-	7	765	c.532C>T	c.(532-534)Cgg>Tgg	p.R178W	WBP11_ENST00000537574.1_Missense_Mutation_p.R178W	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	178	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GAAACTGCCCGAGTTGGAGGT	0.428													34	46					0	0	1	0	0	A	14947660	G	A	14947660	3	1	48	1	0	0	0	0	1	0	0	0	17317	1057	37	1	1417	1	WBP11	12	14947660	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2314451	14947660	118904235	2818	7212										
RERG	85004	broad.mit.edu	37	chr12	15262170	15262170	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgacacaattcatagaatatCtctgtgatgttcccttctcc	5	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:15262170C>A	ENST00000256953.2	-	5	810	c.474G>T	c.(472-474)gaG>gaT	p.E158D	RERG_ENST00000546331.1_Missense_Mutation_p.E139D|RERG_ENST00000536465.1_Missense_Mutation_p.E158D|RERG_ENST00000538313.1_Missense_Mutation_p.E158D	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	158					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						CATAGAATATCTCTGTGATGT	0.537													46	70					3.05275e-18	4.13032e-18	1	1	0	A	15262170	C	A	15262170	3	1	48	1	0	0	0	0	1	0	0	0	13283	912	32	2	129	2	RERG	12	15262170	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	314510	15262170	118589725	2819	7213										
RERG	85004	broad.mit.edu	37	chr12	15262229	15262229	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaaaaagcacaagccaattCtgtggccagcttctctcctt	7	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:15262229C>A	ENST00000256953.2	-	5	751	c.415G>T	c.(415-417)Gaa>Taa	p.E139*	RERG_ENST00000546331.1_Nonsense_Mutation_p.E120*|RERG_ENST00000536465.1_Nonsense_Mutation_p.E139*|RERG_ENST00000538313.1_Nonsense_Mutation_p.E139*	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	139					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						CAAGCCAATTCTGTGGCCAGC	0.493													5	128					0.000602214	0.000636035	1	1	0	A	15262229	C	A	15262229	4	1	48	1	0	0	0	0	0	1	0	0	13283	922	32	2	188	2	RERG	12	15262229	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	59	15262229	118589666	2820	7214										
PTPRO	5800	broad.mit.edu	37	chr12	15652380	15652380	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattttctcttcacagatttCtttaagggaaaaacagtatt	6	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:15652380C>A	ENST00000281171.4	+	4	843	c.513C>A	c.(511-513)ttC>ttA	p.F171L	PTPRO_ENST00000348962.2_Missense_Mutation_p.F171L|PTPRO_ENST00000543886.1_Missense_Mutation_p.F171L	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	171	Fibronectin type-III 2.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TCACAGATTTCTTTAAGGGAA	0.328													23	26					9.57634e-11	1.18295e-10	1	1	0	A	15652380	C	A	15652380	3	1	48	1	0	0	0	0	1	0	0	0	12860	912	32	2	527	2	PTPRO	12	15652380	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	390151	15652380	118199515	2821	7215										
PIK3C2G	5288	broad.mit.edu	37	chr12	18435082	18435082	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagcagtatgaacaccaaGaatttctctttgtaaatcaa	5	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:18435082G>T	ENST00000433979.1	+	2	183	c.67G>T	c.(67-69)Gaa>Taa	p.E23*	PIK3C2G_ENST00000538779.1_Nonsense_Mutation_p.E23*|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000266497.5_Nonsense_Mutation_p.E23*|PIK3C2G_ENST00000535651.1_Nonsense_Mutation_p.E23*	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	23					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.E23*(2)		breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TGAACACCAAGAATTTCTCTT	0.388													3	7					6.4e-05	6.95424e-05	1	1	0	T	18435082	G	T	18435082	4	4	48	1	0	0	0	0	0	1	0	0	11958	943	33	2	69	2	PIK3C2G	12	18435082	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2782702	18435082	115416813	2822	7216										
PLEKHA5	54477	broad.mit.edu	37	chr12	19512414	19512414	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgtaaagccagaccatgaAactcctgcaacagaaattgt	8	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:19512414A>C	ENST00000538714.1	+	24	3097	c.3093A>C	c.(3091-3093)gaA>gaC	p.E1031D	PLEKHA5_ENST00000539256.1_Missense_Mutation_p.E731D|PLEKHA5_ENST00000317589.4_Missense_Mutation_p.E1036D|PLEKHA5_ENST00000429027.2_Missense_Mutation_p.E1139D|PLEKHA5_ENST00000299275.6_Missense_Mutation_p.E973D|PLEKHA5_ENST00000424268.1_Missense_Mutation_p.E962D|PLEKHA5_ENST00000355397.3_Missense_Mutation_p.E1031D|PLEKHA5_ENST00000359180.3_Missense_Mutation_p.E917D|PLEKHA5_ENST00000543806.1_Missense_Mutation_p.E955D	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	973							1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					CAGACCATGAAACTCCTGCAA	0.388													7	50					0	0	1	0	0	C	19512414	A	C	19512414	3	2	48	1	0	0	0	0	1	0	0	0	12106	11	1	4	3323	4	PLEKHA5	12	19512414	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1077332	19512414	114339481	2823	7217										
PDE3A	5139	broad.mit.edu	37	chr12	20801671	20801671	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagaatcatcacgcagctgCtgcatggaatcttttcatgt	10	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:20801671C>A	ENST00000359062.3	+	13	2655	c.2615C>A	c.(2614-2616)gCt>gAt	p.A872D	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	872	Catalytic (By similarity).|Poly-Ala.				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CACGCAGCTGCTGCATGGAAT	0.378													21	48					2.98393e-07	3.42142e-07	1	1	0	A	20801671	C	A	20801671	3	1	48	1	0	0	0	0	1	0	0	0	11683	797	28	5	2665	5	PDE3A	12	20801671	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1289257	20801671	113050224	2824	7218										
SLCO1B3	28234	broad.mit.edu	37	chr12	21028325	21028325	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaagaaaaatttcactatCattgcatgtgctgaaaacaa	6	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:21028325C>A	ENST00000381545.3	+	9	1103	c.884C>A	c.(883-885)tCa>tAa	p.S295*	SLCO1B3_ENST00000261196.2_Nonsense_Mutation_p.S295*|SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000553473.1_Nonsense_Mutation_p.S295*|LST3_ENST00000540229.1_Nonsense_Mutation_p.S295*	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	295					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATTTCACTATCATTGCATGTG	0.313													4	38					0.00024832	0.000265255	1	1	0	A	21028325	C	A	21028325	4	1	48	1	0	0	0	0	0	1	0	0	14778	838	29	2	910	2	SLCO1B3	12	21028325	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	226654	21028325	112823570	2825	7219										
SLCO1B1	10599	broad.mit.edu	37	chr12	21294589	21294589	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagatactgcaatggattGaaggtagaataagttttatg	10	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:21294589G>A	ENST00000256958.2	+	2	177	c.81G>A	c.(79-81)ttG>ttA	p.L27L		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	27					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GCAATGGATTGAAGGTAGAAT	0.279													14	26					0	0	1	0	0	A	21294589	G	A	21294589	2	1	48	1	0	0	0	0	0	0	0	1	14777	1281	45	3		3	SLCO1B1	12	21294589	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	266264	21294589	112557306	2826	7220										
SLCO1A2	6579	broad.mit.edu	37	chr12	21422631	21422631	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagatgacacttcctcaaaaGaattaagatgattaaggctg	8	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:21422631G>T	ENST00000307378.6	-	16	2584	c.1864C>A	c.(1864-1866)Ctt>Att	p.L622I	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.L490I|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.L490I|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.L622I	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	622					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TTCCTCAAAAGAATTAAGATG	0.358													34	53					9.93527e-08	1.15593e-07	1	1	0	T	21422631	G	T	21422631	3	4	48	1	0	0	0	0	1	0	0	0	14776	942	33	2	152	2	SLCO1A2	12	21422631	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	128042	21422631	112429264	2827	7221										
SLCO1A2	6579	broad.mit.edu	37	chr12	21453329	21453329	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacctcttctttttgtttgTcttcattttcatttttaatg	4	7	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:21453329T>G	ENST00000307378.6	-	9	1583	c.863A>C	c.(862-864)gAc>gCc	p.D288A	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.D156A|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.D156A|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.D286A|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.D288A	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	288					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TTTTTGTTTGTCTTCATTTTC	0.318													8	16					0	0	1	0	0	G	21453329	T	G	21453329	3	3	48	1	0	0	0	0	1	0	0	0	14776	1667	58	4	1181	4	SLCO1A2	12	21453329	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	30698	21453329	112398566	2828	7222										
PYROXD1	79912	broad.mit.edu	37	chr12	21615024	21615024	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgctacaggagttacaccAaatgtagaaccttttctcca	7	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:21615024A>G	ENST00000538582.1	+	9	1503	c.750A>G	c.(748-750)ccA>ccG	p.P250P	PYROXD1_ENST00000545178.1_3'UTR|PYROXD1_ENST00000240651.9_Silent_p.P321P			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	321							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						GAGTTACACCAAATGTAGAAC	0.348													8	31					0	0	1	0	0	G	21615024	A	G	21615024	2	3	48	1	0	0	0	0	0	0	0	1	12917	117	5	4		4	PYROXD1	12	21615024	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	161695	21615024	112236871	2829	7223										
GYS2	2998	broad.mit.edu	37	chr12	21733410	21733410	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagttctctccccattcatCtgctgttgttttggcctttg	7	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:21733410C>T	ENST00000261195.2	-	2	423	c.169G>A	c.(169-171)Gat>Aat	p.D57N		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	57					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CCCCATTCATCTGCTGTTGTT	0.363													25	55					0	0	1	0	0	T	21733410	C	T	21733410	3	4	48	1	0	0	0	0	1	0	0	0	6953	913	32	3	2002	3	GYS2	12	21733410	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	118386	21733410	112118485	2830	7224										
ABCC9	10060	broad.mit.edu	37	chr12	22025633	22025633	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagagaggacttcccacaTcctacttggcccacaatcat	7	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:22025633T>C	ENST00000261200.4	-	16	2123	c.2124A>G	c.(2122-2124)ggA>ggG	p.G708G	ABCC9_ENST00000345162.2_Silent_p.G672G|RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000261201.4_Silent_p.G708G	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	708	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTCCCACATCCTACTTGGC	0.413													61	95					0	0	1	0	0	C	22025633	T	C	22025633	2	2	48	1	0	0	0	0	0	0	0	1	59	1422	50	4		4	ABCC9	12	22025633	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	292223	22025633	111826262	2831	7225										
ABCC9	10060	broad.mit.edu	37	chr12	22063775	22063775	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cataccagcagagctccacgGaggttaatgccagtctctat	9	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:22063775G>T	ENST00000261200.4	-	7	1148	c.1149C>A	c.(1147-1149)ctC>ctA	p.L383L	ABCC9_ENST00000345162.2_Silent_p.L383L|ABCC9_ENST00000261201.4_Silent_p.L383L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	383	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAGCTCCACGGAGGTTAATGC	0.408													22	53					7.87624e-14	1.01695e-13	1	1	0	T	22063775	G	T	22063775	2	4	48	1	0	0	0	0	0	0	0	1	59	1161	41	2		2	ABCC9	12	22063775	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	38142	22063775	111788120	2832	7226										
CASC1	55259	broad.mit.edu	37	chr12	25264728	25264728	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgtttataataacataaAaatgagagtgtctagtagga	8	2	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:25264728A>C	ENST00000354189.5	-	14	1966	c.1931T>G	c.(1930-1932)tTt>tGt	p.F644C	CASC1_ENST00000395990.2_Missense_Mutation_p.F540C|CASC1_ENST00000320267.9_Missense_Mutation_p.F580C|CASC1_ENST00000537577.1_Missense_Mutation_p.F468C|CASC1_ENST00000395987.3_Missense_Mutation_p.F586C|CASC1_ENST00000545133.1_Missense_Mutation_p.F521C	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	580										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			AATAACATAAAAATGAGAGTG	0.294													14	22					0	0	1	0	0	C	25264728	A	C	25264728	3	2	48	1	0	0	0	0	1	0	0	0	2678	14	1	4	423	4	CASC1	12	25264728	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3200953	25264728	108587167	2833	7227										
CASC1	55259	broad.mit.edu	37	chr12	25297311	25297311	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcctaccattttcacttcAatatcaccttgttcctcctc	2	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:25297311A>T	ENST00000354189.5	-	9	1199	c.1164T>A	c.(1162-1164)atT>atA	p.I388I	CASC1_ENST00000395990.2_Silent_p.I284I|CASC1_ENST00000320267.9_Silent_p.I324I|CASC1_ENST00000537577.1_Silent_p.I212I|CASC1_ENST00000395987.3_Silent_p.I330I|CASC1_ENST00000545133.1_Silent_p.I265I|CASC1_ENST00000557684.1_5'UTR	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	324										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TTTTCACTTCAATATCACCTT	0.353													44	86					0	0	1	0	0	T	25297311	A	T	25297311	2	4	48	1	0	0	0	0	0	0	0	1	2678	126	5	4		4	CASC1	12	25297311	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	32583	25297311	108554584	2834	7228										
CASC1	55259	broad.mit.edu	37	chr12	25299943	25299943	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacaagggtaccttggattCttcttgaggtttgcccacac	9	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:25299943C>T	ENST00000354189.5	-	8	890	c.855G>A	c.(853-855)aaG>aaA	p.K285K	CASC1_ENST00000395990.2_Silent_p.K181K|CASC1_ENST00000320267.9_Silent_p.K221K|CASC1_ENST00000537577.1_Silent_p.K109K|CASC1_ENST00000395987.3_Silent_p.K227K|CASC1_ENST00000545133.1_Silent_p.K162K|CASC1_ENST00000557684.1_5'UTR	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	221										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ACCTTGGATTCTTCTTGAGGT	0.418													22	39					0	0	1	0	0	T	25299943	C	T	25299943	2	4	48	1	0	0	0	0	0	0	0	1	2678	912	32	3		3	CASC1	12	25299943	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2632	25299943	108551952	2835	7229										
ITPR2	3709	broad.mit.edu	37	chr12	26775334	26775334	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagttgaactggatttttttCttttctataaaaccaaaaac	4	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:26775334C>A	ENST00000381340.3	-	25	3543	c.3127G>T	c.(3127-3129)Gaa>Taa	p.E1043*	ITPR2_ENST00000545902.1_5'UTR	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1043					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	p.E1043*(1)	ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GGATTTTTTTCTTTTCTATAA	0.373													6	5					3.59834e-05	3.93264e-05	1	1	0	A	26775334	C	A	26775334	4	1	48	1	0	0	0	0	0	1	0	0	7964	922	32	2	5110	2	ITPR2	12	26775334	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1475391	26775334	107076561	2836	7230										
MRPS35	60488	broad.mit.edu	37	chr12	27869353	27869353	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttatccagtaaaaaagggcGtgcccatggcaaaggaggga	14	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:27869353G>A	ENST00000081029.3	+	3	354	c.283G>A	c.(283-285)Gtg>Atg	p.V95M	MRPS35_ENST00000538315.1_Missense_Mutation_p.V95M	NM_021821.3	NP_068593.2	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35	95					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit		p.V95M(1)		breast(1)|endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	6	Lung SC(9;0.0873)					AAAAAAGGGCGTGCCCATGGC	0.443													16	43					0	0	1	0	0	A	27869353	G	A	27869353	3	1	48	1	0	0	0	0	1	0	0	0	9892	1145	40	1	293	1	MRPS35	12	27869353	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1094019	27869353	105982542	2837	7231										
OVCH1	341350	broad.mit.edu	37	chr12	29642678	29642678	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgatgggaagttccatttCttgtaggacatttgaatatt	9	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:29642678C>T	ENST00000318184.5	-	6	576	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	193	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AGTTCCATTTCTTGTAGGACA	0.448													6	10					0	0	1	0	0	T	29642678	C	T	29642678	3	4	48	1	0	0	0	0	1	0	0	0	11369	922	32	3	2919	3	OVCH1	12	29642678	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1773325	29642678	104209217	2838	7232										
TMTC1	83857	broad.mit.edu	37	chr12	29659799	29659799	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatgtttgatccttttctcGaacttcttgtaatcgttttt	5	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:29659799G>A	ENST00000256062.5	-	18	2778	c.2305C>T	c.(2305-2307)Cga>Tga	p.R769*	TMTC1_ENST00000319685.8_5'UTR|TMTC1_ENST00000552618.1_Nonsense_Mutation_p.R901*|TMTC1_ENST00000551659.1_Nonsense_Mutation_p.R939*|TMTC1_ENST00000539277.1_Nonsense_Mutation_p.R877*	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	877						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TCCTTTTCTCGAACTTCTTGT	0.453													37	74					0	0	1	0	0	A	29659799	G	A	29659799	4	1	48	1	0	0	0	0	0	1	0	0	16319	1066	37	1	23	1	TMTC1	12	29659799	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17121	29659799	104192096	2839	7233										
CAPRIN2	65981	broad.mit.edu	37	chr12	30881756	30881756	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggctgttttgaatcctgTtcttcacacatgggagtggt	11	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:30881756T>G	ENST00000251071.5	-	8	2358	c.1608A>C	c.(1606-1608)gaA>gaC	p.E536D	CAPRIN2_ENST00000298892.5_Missense_Mutation_p.E536D|CAPRIN2_ENST00000538387.1_5'UTR|CAPRIN2_ENST00000308433.5_Missense_Mutation_p.E203D|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.E536D|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.E536D	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	536					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TTGAATCCTGTTCTTCACACA	0.433													32	86					0	0	1	0	0	G	30881756	T	G	30881756	3	3	48	1	0	0	0	0	1	0	0	0	2654	1722	60	4	1819	4	CAPRIN2	12	30881756	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1221957	30881756	102970139	2840	7234										
DENND5B	160518	broad.mit.edu	37	chr12	31579260	31579260	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttttaataagccttctacGaatttacagttggtctgtgc	7	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:31579260G>A	ENST00000389082.5	-	9	2469	c.2205C>T	c.(2203-2205)ttC>ttT	p.F735F	DENND5B_ENST00000536562.1_Silent_p.F770F|DENND5B_ENST00000306833.6_Silent_p.F770F	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	735						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGCCTTCTACGAATTTACAGT	0.398													7	11					0	0	1	0	0	A	31579260	G	A	31579260	2	1	48	1	0	0	0	0	0	0	0	1	4465	1049	37	1		1	DENND5B	12	31579260	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	697504	31579260	102272635	2841	7235										
FGD4	121512	broad.mit.edu	37	chr12	32751469	32751469	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcacaaaatagccaatgaActtttgcttactgaaagagc	6	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:32751469A>G	ENST00000427716.2	+	5	1063	c.639A>G	c.(637-639)gaA>gaG	p.E213E	FGD4_ENST00000266482.3_5'UTR|FGD4_ENST00000381025.3_5'UTR|FGD4_ENST00000525053.1_Silent_p.E325E|FGD4_ENST00000531134.1_Silent_p.E298E|FGD4_ENST00000534526.2_Silent_p.E350E|FGD4_ENST00000546442.1_Silent_p.E120E	NM_139241.2	NP_640334.2	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	213	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TAGCCAATGAACTTTTGCTTA	0.308													21	37					0	0	1	0	0	G	32751469	A	G	32751469	2	3	48	1	0	0	0	0	0	0	0	1	5867	40	2	4		4	FGD4	12	32751469	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1172209	32751469	101100426	2842	7236										
FGD4	121512	broad.mit.edu	37	chr12	32754280	32754280	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagagatggtgaataaaatCttttctaatatttcatcaat	6	5	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:32754280C>A	ENST00000427716.2	+	6	1183	c.759C>A	c.(757-759)atC>atA	p.I253I	FGD4_ENST00000266482.3_Silent_p.I5I|FGD4_ENST00000381025.3_Silent_p.I5I|FGD4_ENST00000525053.1_Silent_p.I365I|FGD4_ENST00000531134.1_Silent_p.I338I|FGD4_ENST00000534526.2_Silent_p.I390I|FGD4_ENST00000546442.1_Silent_p.I160I	NM_139241.2	NP_640334.2	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	253	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TGAATAAAATCTTTTCTAATA	0.353													20	38					6.44725e-10	7.85205e-10	1	1	0	A	32754280	C	A	32754280	2	1	48	1	0	0	0	0	0	0	0	1	5867	903	32	2		2	FGD4	12	32754280	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2811	32754280	101097615	2843	7237										
FGD4	121512	broad.mit.edu	37	chr12	32772699	32772699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctaaattcacagttcgaaCcagggttggcattgatggaa	10	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:32772699C>T	ENST00000427716.2	+	11	1830	c.1406C>T	c.(1405-1407)aCc>aTc	p.T469I	FGD4_ENST00000525053.1_Missense_Mutation_p.T581I|FGD4_ENST00000546442.1_Missense_Mutation_p.T376I|FGD4_ENST00000266482.3_Missense_Mutation_p.T221I|FGD4_ENST00000531134.1_Missense_Mutation_p.T554I|FGD4_ENST00000534526.2_Missense_Mutation_p.T606I|FGD4_ENST00000381025.3_Missense_Mutation_p.T221I	NM_139241.2	NP_640334.2	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	469	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					ACAGTTCGAACCAGGGTTGGC	0.413													29	64					0	0	1	0	0	T	32772699	C	T	32772699	3	4	48	1	0	0	0	0	1	0	0	0	5867	507	18	3	1440	3	FGD4	12	32772699	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18419	32772699	101079196	2844	7238										
DNM1L	10059	broad.mit.edu	37	chr12	32884447	32884447	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagcaattacagtacacaggTaacggagagaaatgtaacag	10	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:32884447T>C	ENST00000452533.2	+	11	1520		c.e11+2		DNM1L_ENST00000547312.1_Splice_Site|DNM1L_ENST00000549701.1_Splice_Site|DNM1L_ENST00000414834.2_Splice_Site|DNM1L_ENST00000553257.1_Splice_Site|YARS2_ENST00000551673.1_Intron|DNM1L_ENST00000381000.4_Splice_Site|DNM1L_ENST00000358214.5_Splice_Site|DNM1L_ENST00000266481.6_Splice_Site	NM_012062.3|NM_012063.2	NP_036192.2|NP_036193.2	O00429	DNM1L_HUMAN	dynamin 1-like						cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AGTACACAGGTAACGGAGAGA	0.433													6	61					0	0	1	0	0	C	32884447	T	C	32884447	5	2	48	1	0	0	0	0	0	0	1	0	4698	1652	57	4	1400	4	DNM1L	12	32884447	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	111748	32884447	100967448	2845	7239										
YARS2	51067	broad.mit.edu	37	chr12	32908477	32908477	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgccgtggcgcctcccaccAgcgcgatcacgttgtggccc	13	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:32908477A>C	ENST00000324868.8	-	1	359	c.332T>G	c.(331-333)cTg>cGg	p.L111R		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	111					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	GCCTCCCACCAGCGCGATCAC	0.672											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	60					0	0	1	0	0	C	32908477	A	C	32908477	3	2	48	1	0	0	0	0	1	0	0	0	17527	188	7	4	1121	4	YARS2	12	32908477	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	24030	32908477	100943418	2846	7240										
ALG10B	144245	broad.mit.edu	37	chr12	38714484	38714484	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctattctactttttttcattTactctctttttttcttttcc	0	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:38714484T>G	ENST00000308742.4	+	3	1207	c.891T>G	c.(889-891)ttT>ttG	p.F297L	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	297					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TTTTTTCATTTACTCTCTTTT	0.348													30	85					0	0	1	0	0	G	38714484	T	G	38714484	3	3	48	1	0	0	0	0	1	0	0	0	509	1751	61	4	901	4	ALG10B	12	38714484	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5806007	38714484	95137411	2847	7241										
ALG10B	144245	broad.mit.edu	37	chr12	38714839	38714839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagaaactgctggaatttCgttacttcattttaccttat	5	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:38714839C>T	ENST00000308742.4	+	3	1562	c.1246C>T	c.(1246-1248)Cgt>Tgt	p.R416C	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	416					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GCTGGAATTTCGTTACTTCAT	0.333													31	91					0	0	1	0	0	T	38714839	C	T	38714839	3	4	48	1	0	0	0	0	1	0	0	0	509	884	31	1	1256	1	ALG10B	12	38714839	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	355	38714839	95137056	2848	7242										
CPNE8	144402	broad.mit.edu	37	chr12	39161529	39161529	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgttcgcacaaaattgcatCaaaacggcatcctaaaaaca	5	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:39161529C>T	ENST00000331366.5	-	8	579	c.483G>A	c.(481-483)ttG>ttA	p.L161L	CPNE8_ENST00000360449.3_Silent_p.L149L	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	161	C2 2.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				AAAATTGCATCAAAACGGCAT	0.328													19	35					0	0	1	0	0	T	39161529	C	T	39161529	2	4	48	1	0	0	0	0	0	0	0	1	3841	825	29	3		3	CPNE8	12	39161529	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	446690	39161529	94690366	2849	7243										
CPNE8	144402	broad.mit.edu	37	chr12	39242380	39242380	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagtcaaaacgaagattctCtctttcttcaaaaaagtagt	5	8	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:39242380C>T	ENST00000331366.5	-	4	367	c.271G>A	c.(271-273)Gag>Aag	p.E91K	CPNE8_ENST00000360449.3_Missense_Mutation_p.E79K	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	91	C2 1.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CGAAGATTCTCTCTTTCTTCA	0.308													6	24					0	0	1	0	0	T	39242380	C	T	39242380	3	4	48	1	0	0	0	0	1	0	0	0	3841	922	32	3	1491	3	CPNE8	12	39242380	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80851	39242380	94609515	2850	7244										
ABCD2	225	broad.mit.edu	37	chr12	40010816	40010816	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcaaagccagttgcagtgAtaataggtatagccaccata	9	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:40010816A>C	ENST00000308666.3	-	2	1229	c.1094T>G	c.(1093-1095)aTc>aGc	p.I365S		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	365	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						AGTTGCAGTGATAATAGGTAT	0.338													31	48					0	0	1	0	0	C	40010816	A	C	40010816	3	2	48	1	0	0	0	0	1	0	0	0	61	333	12	4	1164	4	ABCD2	12	40010816	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	768436	40010816	93841079	2851	7245										
LRRK2	120892	broad.mit.edu	37	chr12	40668394	40668394	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgattttagttcattggaAatcctgggattcagaaatgt	9	4	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:40668394A>C	ENST00000298910.7	+	15	1724	c.1666A>C	c.(1666-1668)Aat>Cat	p.N556H	LRRK2_ENST00000343742.2_Missense_Mutation_p.N556H	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	556					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTTCATTGGAAATCCTGGGAT	0.318													15	52					0	0	1	0	0	C	40668394	A	C	40668394	3	2	48	1	0	0	0	0	1	0	0	0	9077	14	1	4	1724	4	LRRK2	12	40668394	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	657578	40668394	93183501	2852	7246										
LRRK2	120892	broad.mit.edu	37	chr12	40749930	40749930	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttagcaaacaaaaaaatTttcttttggttggaaccgct	6	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:40749930T>G	ENST00000298910.7	+	46	6842	c.6784T>G	c.(6784-6786)Ttt>Gtt	p.F2262V		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2262					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ACAAAAAAATTTTCTTTTGGT	0.289													4	10					0	0	1	0	0	G	40749930	T	G	40749930	3	3	48	1	0	0	0	0	1	0	0	0	9077	1841	64	4	6966	4	LRRK2	12	40749930	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	81536	40749930	93101965	2853	7247										
PDZRN4	29951	broad.mit.edu	37	chr12	41967015	41967015	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagcaaggagaaggttttaGaaggcagcaagcttcctgat	12	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:41967015G>T	ENST00000298919.7	+	10	2042	c.1654G>T	c.(1654-1656)Gaa>Taa	p.E552*	PDZRN4_ENST00000402685.2_Nonsense_Mutation_p.E812*|PDZRN4_ENST00000539469.2_Nonsense_Mutation_p.E554*			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	812							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGGTTTTAGAAGGCAGCAA	0.502													26	213					9.39395e-14	1.21013e-13	1	1	0	T	41967015	G	T	41967015	4	4	48	1	0	0	0	0	0	1	0	0	11756	943	33	2	2545	2	PDZRN4	12	41967015	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1217085	41967015	91884880	2854	7248										
ADAMTS20	80070	broad.mit.edu	37	chr12	43777415	43777415	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaggagggttcctgcaattCttggatgtaagagatatggt	13	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:43777415C>A	ENST00000389420.3	-	31	4742	c.4743G>T	c.(4741-4743)aaG>aaT	p.K1581N		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1581	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCCTGCAATTCTTGGATGTAA	0.368													9	22					7.48243e-07	8.49459e-07	1	1	0	A	43777415	C	A	43777415	3	1	48	1	0	0	0	0	1	0	0	0	265	912	32	2	1024	2	ADAMTS20	12	43777415	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1810400	43777415	90074480	2855	7249										
NELL2	4753	broad.mit.edu	37	chr12	45097553	45097553	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagagccctaaaaccatctCgacagctacaaacagccctg	7	14	1	1	rs114802162	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:45097553C>T	ENST00000429094.2	-	12	1778	c.1274G>A	c.(1273-1275)cGa>cAa	p.R425Q	NELL2_ENST00000549027.1_Missense_Mutation_p.R424Q|NELL2_ENST00000395487.2_Missense_Mutation_p.R424Q|NELL2_ENST00000452445.2_Missense_Mutation_p.R425Q|NELL2_ENST00000333837.4_Missense_Mutation_p.R448Q|NELL2_ENST00000437801.2_Missense_Mutation_p.R475Q|NELL2_ENST00000551601.1_Missense_Mutation_p.R424Q	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	425	EGF-like 1.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity	p.R475Q(1)|p.R425Q(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AAAACCATCTCGACAGCTACA	0.393													23	41					0	0	1	0	0	T	45097553	C	T	45097553	3	4	48	1	0	0	0	0	1	0	0	0	10380	884	31	1	1212	1	NELL2	12	45097553	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1320138	45097553	88754342	2856	7250										
NELL2	4753	broad.mit.edu	37	chr12	45169892	45169892	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcaagtcctttcacaataGcactgatccaatctattcat	5	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:45169892G>A	ENST00000429094.2	-	8	1308	c.804C>T	c.(802-804)tgC>tgT	p.C268C	NELL2_ENST00000549027.1_Silent_p.C267C|NELL2_ENST00000395487.2_Silent_p.C267C|NELL2_ENST00000452445.2_Silent_p.C268C|NELL2_ENST00000333837.4_Silent_p.C291C|NELL2_ENST00000437801.2_Silent_p.C318C|NELL2_ENST00000551601.1_Silent_p.C267C	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	268					cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTTCACAATAGCACTGATCCA	0.458													19	49					0	0	1	0	0	A	45169892	G	A	45169892	2	1	48	1	0	0	0	0	0	0	0	1	10380	963	34	3		3	NELL2	12	45169892	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	72339	45169892	88682003	2857	7251										
ANO6	196527	broad.mit.edu	37	chr12	45740823	45740823	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaggaaaagacaagcatacGaatctaaccttatctgtcat	7	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:45740823G>A	ENST00000320560.8	+	4	500	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	ANO6_ENST00000425752.2_Missense_Mutation_p.E100K|ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000435642.1_Missense_Mutation_p.E100K|ANO6_ENST00000441606.2_Missense_Mutation_p.E82K|ANO6_ENST00000423947.3_Missense_Mutation_p.E121K	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	100					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						ACAAGCATACGAATCTAACCT	0.393													4	51					0	0	1	0	0	A	45740823	G	A	45740823	3	1	48	1	0	0	0	0	1	0	0	0	695	1059	37	1	332	1	ANO6	12	45740823	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	570931	45740823	88111072	2858	7252										
ARID2	196528	broad.mit.edu	37	chr12	46246346	46246346	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaacctctgttatacagggAcatcaaatcatagcagttcc	6	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:46246346A>G	ENST00000334344.6	+	15	4612	c.4440A>G	c.(4438-4440)ggA>ggG	p.G1480G	ARID2_ENST00000444670.1_Silent_p.G1090G|ARID2_ENST00000457135.1_Silent_p.G88G|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Silent_p.G1331G	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1480					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTATACAGGGACATCAAATCA	0.448			"N, S, F"		hepatocellular carcinoma								38	64					0	0	1	0	0	G	46246346	A	G	46246346	2	3	48	1	0	0	0	0	0	0	0	1	912	262	10	4		4	ARID2	12	46246346	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	505523	46246346	87605549	2859	7253										
AMIGO2	347902	broad.mit.edu	37	chr12	47471533	47471533	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcaggggcatggagtcagaTagaggtacaaaagtaccaaa	13	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:47471533T>C	ENST00000266581.4	-	2	1719	c.1253A>G	c.(1252-1254)tAt>tGt	p.Y418C	AMIGO2_ENST00000429635.1_Missense_Mutation_p.Y418C|AMIGO2_ENST00000550413.1_Missense_Mutation_p.Y418C|AMIGO2_ENST00000321382.3_Missense_Mutation_p.Y418C	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	418					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					TGGAGTCAGATAGAGGTACAA	0.463													27	34					0	0	1	0	0	C	47471533	T	C	47471533	3	2	48	1	0	0	0	0	1	0	0	0	572	1406	49	4	319	4	AMIGO2	12	47471533	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1225187	47471533	86380362	2860	7254										
CCNT1	904	broad.mit.edu	37	chr12	49087243	49087243	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatcttggctggatgatcaAacacagcccctccagtctct	7	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:49087243A>C	ENST00000261900.3	-	9	1976	c.1754T>G	c.(1753-1755)tTt>tGt	p.F585C		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	585	Ser-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						TGGATGATCAAACACAGCCCC	0.453													30	49					0	0	1	0	0	C	49087243	A	C	49087243	3	2	48	1	0	0	0	0	1	0	0	0	2956	14	1	4	430	4	CCNT1	12	49087243	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1615710	49087243	84764652	2861	7255										
CCNT1	904	broad.mit.edu	37	chr12	49088048	49088048	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taagttgctggatgactcttCggagactggcagggaaggca	15	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:49088048C>T	ENST00000261900.3	-	9	1171	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	317					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						GATGACTCTTCGGAGACTGGC	0.498													38	47					0	0	1	0	0	T	49088048	C	T	49088048	3	4	48	1	0	0	0	0	1	0	0	0	2956	893	31	1	1235	1	CCNT1	12	49088048	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	805	49088048	84763847	2862	7256										
CCNT1	904	broad.mit.edu	37	chr12	49089871	49089871	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatctcccaattggaccacTtgcaagccaggtgaatgcag	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:49089871T>G	ENST00000261900.3	-	7	839	c.617A>C	c.(616-618)aAg>aCg	p.K206T		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	206					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						ATTGGACCACTTGCAAGCCAG	0.502													17	42					0	0	1	0	0	G	49089871	T	G	49089871	3	3	48	1	0	0	0	0	1	0	0	0	2956	1609	56	4	1575	4	CCNT1	12	49089871	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1823	49089871	84762024	2863	7257										
CCDC65	85478	broad.mit.edu	37	chr12	49315203	49315203	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacgtatagcccatccaggtGataaacaacatccaaccact	5	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:49315203G>A	ENST00000320516.4	+	8	1620	c.1432G>A	c.(1432-1434)Gat>Aat	p.D478N	ARF3_ENST00000398092.4_Intron|CCDC65_ENST00000266984.5_Intron	NM_033124.4	NP_149115.2	Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	478										breast(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	15						CCATCCAGGTGATAAACAACA	0.413													24	49					0	0	1	0	0	A	49315203	G	A	49315203	3	1	48	1	0	0	0	0	1	0	0	0	2857	1290	45	3	1462	3	CCDC65	12	49315203	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	225332	49315203	84536692	2864	7258										
DHH	50846	broad.mit.edu	37	chr12	49484166	49484166	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcggccgccaaaacccagtCtccgcggtgcagttcccgca	10	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:49484166C>A	ENST00000266991.2	-	3	973	c.667G>T	c.(667-669)Gac>Tac	p.D223Y	RP11-386G11.8_ENST00000553174.1_RNA	NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	223					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						AAAACCCAGTCTCCGCGGTGC	0.677													5	14					0.217242	0.218251	1	1	0	A	49484166	C	A	49484166	3	1	48	1	0	0	0	0	1	0	0	0	4511	913	32	2	527	2	DHH	12	49484166	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	168963	49484166	84367729	2865	7259										
TROAP	10024	broad.mit.edu	37	chr12	49725173	49725173	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accctgtggctacattactcGaatggcaggatgccctggtg	12	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:49725173G>A	ENST00000551245.1	+	13	2656	c.2545G>A	c.(2545-2547)Gaa>Aaa	p.E849K	TROAP_ENST00000547923.1_Missense_Mutation_p.E438K|TROAP_ENST00000257909.3_Missense_Mutation_p.E759K			Q12815	TROAP_HUMAN	trophinin associated protein	350					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TACATTACTCGAATGGCAGGA	0.642											OREG0021792	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	55					0	0	1	0	0	A	49725173	G	A	49725173	3	1	48	1	0	0	0	0	1	0	0	0	16635	1059	37	1	2427	1	TROAP	12	49725173	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	241007	49725173	84126722	2866	7260										
RACGAP1	29127	broad.mit.edu	37	chr12	50410486	50410486	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagattccgcacattcagcaTcatagtatccatctttctgc	5	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:50410486T>G	ENST00000434422.1	-	3	314	c.13A>C	c.(13-15)Atg>Ctg	p.M5L	RACGAP1_ENST00000551016.1_Missense_Mutation_p.M5L|RACGAP1_ENST00000547905.1_Missense_Mutation_p.M5L|RACGAP1_ENST00000427314.2_Missense_Mutation_p.M5L|RACGAP1_ENST00000312377.5_Missense_Mutation_p.M5L|RACGAP1_ENST00000454520.2_Missense_Mutation_p.M5L			Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	5					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(6)	14						ACATTCAGCATCATAGTATCC	0.463													49	90					0	0	1	0	0	G	50410486	T	G	50410486	3	3	48	1	0	0	0	0	1	0	0	0	13028	1435	50	4	1949	4	RACGAP1	12	50410486	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	685313	50410486	83441409	2867	7261										
LIMA1	51474	broad.mit.edu	37	chr12	50571158	50571158	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctgtctctcctttagattCtttgttttgccaggttgttt	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:50571158C>A	ENST00000547825.1	-	5	2332	c.1063G>T	c.(1063-1065)Gaa>Taa	p.E355*	LIMA1_ENST00000552823.1_Nonsense_Mutation_p.E497*|LIMA1_ENST00000552909.1_Nonsense_Mutation_p.E496*|LIMA1_ENST00000552783.1_Nonsense_Mutation_p.E498*|LIMA1_ENST00000552491.1_Nonsense_Mutation_p.E354*|LIMA1_ENST00000394943.3_Nonsense_Mutation_p.E658*|LIMA1_ENST00000341247.4_Nonsense_Mutation_p.E657*	NM_001243775.1	NP_001230704.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	657					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						CCTTTAGATTCTTTGTTTTGC	0.423													89	190					3.62344e-47	5.25254e-47	1	1	0	A	50571158	C	A	50571158	4	1	48	1	0	0	0	0	0	1	0	0	8835	922	32	2	314	2	LIMA1	12	50571158	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	160672	50571158	83280737	2868	7262										
LARP4	113251	broad.mit.edu	37	chr12	50847289	50847289	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgctaagaatggttatcGattaatggattctagtatct	8	4	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:50847289G>A	ENST00000398473.2	+	9	963	c.851G>A	c.(850-852)cGa>cAa	p.R284Q	LARP4_ENST00000522085.1_Missense_Mutation_p.R284Q|LARP4_ENST00000293618.8_Missense_Mutation_p.R284Q|LARP4_ENST00000347328.5_Intron|LARP4_ENST00000429001.3_Missense_Mutation_p.R290Q|LARP4_ENST00000518561.1_Missense_Mutation_p.R214Q|LARP4_ENST00000518444.1_Missense_Mutation_p.R283Q	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	284							nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						AATGGTTATCGATTAATGGAT	0.348													23	54					0	0	1	0	0	A	50847289	G	A	50847289	3	1	48	1	0	0	0	0	1	0	0	0	8668	1058	37	1	885	1	LARP4	12	50847289	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	276131	50847289	83004606	2869	7263										
TMPRSS12	283471	broad.mit.edu	37	chr12	51279214	51279214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaatattttctgaagccaGaagggaacttgtcaaacaag	8	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:51279214G>A	ENST00000551456.1	+	4	883	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	TMPRSS12_ENST00000398458.3_Intron			Q86WS5	TMPSC_HUMAN	transmembrane (C-terminal) protease, serine 12	201	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	18						TCTGAAGCCAGAAGGGAACTT	0.328													31	61					0	0	1	0	0	A	51279214	G	A	51279214	3	1	48	1	0	0	0	0	1	0	0	0	16303	957	33	3		3	TMPRSS12	12	51279214	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	431925	51279214	82572681	2870	7264										
SLC11A2	4891	broad.mit.edu	37	chr12	51399200	51399200	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtgaaagcccagagtttaCgaaagctaaaacaagagtac	10	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:51399200C>T	ENST00000394904.3	-	4	339	c.290G>A	c.(289-291)cGt>cAt	p.R97H	SLC11A2_ENST00000262051.7_Missense_Mutation_p.R68H|SLC11A2_ENST00000262052.5_Missense_Mutation_p.R68H|SLC11A2_ENST00000546743.1_5'UTR|SLC11A2_ENST00000547198.1_Missense_Mutation_p.R68H|SLC11A2_ENST00000541174.2_Missense_Mutation_p.R68H|SLC11A2_ENST00000545993.2_Missense_Mutation_p.R64H|SLC11A2_ENST00000549193.1_5'UTR|SLC11A2_ENST00000547688.1_Missense_Mutation_p.R97H	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	68					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity	p.R68H(1)		breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						CCAGAGTTTACGAAAGCTAAA	0.413													9	30					0	0	1	0	0	T	51399200	C	T	51399200	3	4	48	1	0	0	0	0	1	0	0	0	14435	536	19	1	1616	1	SLC11A2	12	51399200	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	119986	51399200	82452695	2871	7265										
LETMD1	25875	broad.mit.edu	37	chr12	51442897	51442897	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccaagacaaaagcgattaAtgggaaataccatcgtttct	7	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:51442897A>C	ENST00000418425.2	+	2	222	c.203A>C	c.(202-204)aAt>aCt	p.N68T	LETMD1_ENST00000552739.1_Intron|LETMD1_ENST00000262055.4_Missense_Mutation_p.N68T|LETMD1_ENST00000380123.2_Missense_Mutation_p.N68T|LETMD1_ENST00000547008.1_Missense_Mutation_p.N68T|LETMD1_ENST00000550929.1_Missense_Mutation_p.N12T|LETMD1_ENST00000548516.1_3'UTR	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	68	Required and sufficient for mitochondrial import.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						AAAGCGATTAATGGGAAATAC	0.403													8	25					0	0	1	0	0	C	51442897	A	C	51442897	3	2	48	1	0	0	0	0	1	0	0	0	8774	101	4	4	209	4	LETMD1	12	51442897	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	43697	51442897	82408998	2872	7266										
BIN2	51411	broad.mit.edu	37	chr12	51695879	51695879	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccagtttctcctcgtagtcTtcccaaaggagatcattatt	7	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:51695879T>G	ENST00000267012.4	-	5	394	c.333A>C	c.(331-333)gaA>gaC	p.E111D	BIN2_ENST00000452142.2_Intron|BIN2_ENST00000544402.1_Missense_Mutation_p.E85D|BIN2_ENST00000604560.1_Missense_Mutation_p.E84D	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	111	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						CCTCGTAGTCTTCCCAAAGGA	0.463													4	36					0	0	1	0	0	G	51695879	T	G	51695879	3	3	48	1	0	0	0	0	1	0	0	0	1432	1606	56	4	1400	4	BIN2	12	51695879	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	252982	51695879	82156016	2873	7267										
SCN8A	6334	broad.mit.edu	37	chr12	52115650	52115650	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacggcgtggtgtccctcatCggcggccccggctcccacat	12	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:52115650C>T	ENST00000354534.5	+	12	2134	c.1956C>T	c.(1954-1956)atC>atT	p.I652I	SCN8A_ENST00000550891.1_Silent_p.I652I|SCN8A_ENST00000545061.1_Silent_p.I652I	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	652					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TGTCCCTCATCGGCGGCCCCG	0.622													27	34					0	0	1	0	0	T	52115650	C	T	52115650	2	4	48	1	0	0	0	0	0	0	0	1	13977	874	31	1		1	SCN8A	12	52115650	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	419771	52115650	81736245	2874	7268										
SCN8A	6334	broad.mit.edu	37	chr12	52183109	52183109	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacaatatctacatgtacatCtattttgtcatcttcatcat	3	9	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:52183109C>A	ENST00000354534.5	+	24	4504	c.4326C>A	c.(4324-4326)atC>atA	p.I1442I	SCN8A_ENST00000545061.1_Silent_p.I1401I	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1442					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ACATGTACATCTATTTTGTCA	0.398													8	52					0.000157383	0.000169016	1	1	0	A	52183109	C	A	52183109	2	1	48	1	0	0	0	0	0	0	0	1	13977	903	32	2		2	SCN8A	12	52183109	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67459	52183109	81668786	2875	7269										
KRT6C	286887	broad.mit.edu	37	chr12	52865252	52865252	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatctcatctgtgagagtgtCtgccttggcttgcagttcaa	11	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:52865252C>A	ENST00000252250.6	-	4	912	c.865G>T	c.(865-867)Gac>Tac	p.D289Y		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	289	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GTGAGAGTGTCTGCCTTGGCT	0.493													11	38					1.08611e-07	1.25818e-07	1	1	0	A	52865252	C	A	52865252	3	1	48	1	0	0	0	0	1	0	0	0	8524	913	32	2	853	2	KRT6C	12	52865252	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	682143	52865252	80986643	2876	7270										
KRT76	51350	broad.mit.edu	37	chr12	53167390	53167390	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgagccccacaaactcattCtctgcggcagtgcgtttgtt	9	12	2	1	rs148390412		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:53167390C>A	ENST00000332411.2	-	3	905	c.852G>T	c.(850-852)gaG>gaT	p.E284D		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	284	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity	p.E284E(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CAAACTCATTCTCTGCGGCAG	0.498													25	42					5.45024e-15	7.15042e-15	1	1	0	A	53167390	C	A	53167390	3	1	48	1	0	0	0	0	1	0	0	0	8531	912	32	2	1092	2	KRT76	12	53167390	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	302138	53167390	80684505	2877	7271										
SP7	121340	broad.mit.edu	37	chr12	53722254	53722254	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaagagccagttgcagacGaagggcctctcgcctgtgtg	14	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:53722254G>A	ENST00000536324.2	-	3	1255	c.972C>T	c.(970-972)ttC>ttT	p.F324F	SP7_ENST00000303846.3_Silent_p.F324F|SP7_ENST00000537210.2_Silent_p.F306F	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						AGTTGCAGACGAAGGGCCTCT	0.617													43	57					0	0	1	0	0	A	53722254	G	A	53722254	2	1	48	1	0	0	0	0	0	0	0	1	15022	1049	37	1		1	SP7	12	53722254	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	554864	53722254	80129641	2878	7272										
SP7	121340	broad.mit.edu	37	chr12	53722395	53722395	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgctcccagccgctctagCtcctggcaattagggcagtc	11	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:53722395C>T	ENST00000536324.2	-	3	1114	c.831G>A	c.(829-831)gaG>gaA	p.E277E	SP7_ENST00000303846.3_Silent_p.E277E|SP7_ENST00000537210.2_Silent_p.E259E	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						GCCGCTCTAGCTCCTGGCAAT	0.662													12	29					0	0	1	0	0	T	53722395	C	T	53722395	2	4	48	1	0	0	0	0	0	0	0	1	15022	796	28	3		3	SP7	12	53722395	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	141	53722395	80129500	2879	7273										
SP1	0	broad.mit.edu	37	chr12	53777010	53777010	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcagggcagacctttacaActcaagccatctcccaggaa	8	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:53777010A>C	ENST00000426431.2	+	3	1318	c.1258A>C	c.(1258-1260)Act>Cct	p.T420P	SP1_ENST00000327443.4_Missense_Mutation_p.T427P	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	427	Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GACCTTTACAACTCAAGCCAT	0.557													50	87					0	0	1	0	0	C	53777010	A	C	53777010	3	2	48	1	0	0	0	0	1	0	0	0	15012	43	2	4	1289	4	SP1	12	53777010	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	54615	53777010	80074885	2880	7274										
NPFF	8620	broad.mit.edu	37	chr12	53901163	53901163	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacacacactcaccgcggaGagctggtcttcctgctggcc	12	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:53901163G>T	ENST00000267017.3	-	1	259	c.96C>A	c.(94-96)ctC>ctA	p.L32L	RP11-793H13.10_ENST00000591834.1_Intron	NM_003717.2	NP_003708.1	O15130	NPFF_HUMAN	neuropeptide FF-amide peptide precursor	32					neuropeptide signaling pathway|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|prostate(1)|urinary_tract(1)	3						TCACCGCGGAGAGCTGGTCTT	0.567													34	54					1.36615e-20	1.87316e-20	1	1	0	T	53901163	G	T	53901163	2	4	48	1	0	0	0	0	0	0	0	1	10622	929	33	2		2	NPFF	12	53901163	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	124153	53901163	79950732	2881	7275										
CALCOCO1	57658	broad.mit.edu	37	chr12	54110096	54110096	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatctgggccaccttgtctTtcagtcgctgagcctgagca	10	13	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:54110096T>C	ENST00000548263.1	-	8	1001	c.953A>G	c.(952-954)aAa>aGa	p.K318R	CALCOCO1_ENST00000262059.4_Missense_Mutation_p.K318R|CALCOCO1_ENST00000430117.2_Intron|CALCOCO1_ENST00000550804.1_Missense_Mutation_p.K318R			Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	318					steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						CACCTTGTCTTTCAGTCGCTG	0.572													37	52					0	0	1	0	0	C	54110096	T	C	54110096	3	2	48	1	0	0	0	0	1	0	0	0	2595	1841	64	4	1154	4	CALCOCO1	12	54110096	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	208933	54110096	79741799	2882	7276										
CALCOCO1	57658	broad.mit.edu	37	chr12	54115392	54115392	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatctccccatgggaccggGaaatcccctgaaattaagtt	9	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:54115392G>T	ENST00000548263.1	-	6	665	c.617C>A	c.(616-618)tCc>tAc	p.S206Y	CALCOCO1_ENST00000262059.4_Missense_Mutation_p.S206Y|CALCOCO1_ENST00000430117.2_Missense_Mutation_p.S173Y|CALCOCO1_ENST00000550804.1_Missense_Mutation_p.S206Y			Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	206					steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						ATGGGACCGGGAAATCCCCTG	0.542													7	327					0.00198382	0.00207034	1	1	0	T	54115392	G	T	54115392	3	4	48	1	0	0	0	0	1	0	0	0	2595	1174	41	2	1498	2	CALCOCO1	12	54115392	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5296	54115392	79736503	2883	7277										
CBX5	23468	broad.mit.edu	37	chr12	54645982	54645982	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagctcagggcaatccaagTttttctcaggttcccaagta	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:54645982T>C	ENST00000209875.4	-	3	303	c.167A>G	c.(166-168)aAc>aGc	p.N56S	CBX5_ENST00000439541.2_Missense_Mutation_p.N56S|CBX5_ENST00000550411.1_Missense_Mutation_p.N56S	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5	56	Chromo 1.				blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						GCAATCCAAGTTTTTCTCAGG	0.368													16	27					0	0	1	0	0	C	54645982	T	C	54645982	3	2	48	1	0	0	0	0	1	0	0	0	2739	1725	60	4	420	4	CBX5	12	54645982	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	530590	54645982	79205913	2884	7278										
PDE1B	0	broad.mit.edu	37	chr12	54963137	54963137	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacgctgtgcaggctgggAtcttcgtggaacggtgaggc	17	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:54963137A>G	ENST00000243052.3	+	4	833	c.397A>G	c.(397-399)Atc>Gtc	p.I133V	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.I92V|PDE1B_ENST00000550620.1_Missense_Mutation_p.I113V	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	133					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						GCAGGCTGGGATCTTCGTGGA	0.637													20	38					0	0	1	0	0	G	54963137	A	G	54963137	3	3	48	1	0	0	0	0	1	0	0	0	11680	333	12	4	464	4	PDE1B	12	54963137	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	317155	54963137	78888758	2885	7279										
LACRT	90070	broad.mit.edu	37	chr12	55026990	55026990	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcttcctgggcaggatcaGcacccgtcgagtcagaggag	14	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:55026990G>A	ENST00000257867.4	-	2	139	c.86C>T	c.(85-87)gCt>gTt	p.A29V	LACRT_ENST00000547511.1_Missense_Mutation_p.A29V	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	29					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						GGCAGGATCAGCACCCGTCGA	0.597													64	108					0	0	1	0	0	A	55026990	G	A	55026990	3	1	48	1	0	0	0	0	1	0	0	0	8634	971	34	3	346	3	LACRT	12	55026990	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	63853	55026990	78824905	2886	7280										
OR6C70	390327	broad.mit.edu	37	chr12	55863898	55863898	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtcccagaagaataaattCtatctgccttgtatgattct	6	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:55863898C>A	ENST00000327335.4	-	1	24	c.25G>T	c.(25-27)Gaa>Taa	p.E9*	RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						AGAATAAATTCTATCTGCCTT	0.353													15	27					1.99824e-07	2.29918e-07	1	1	0	A	55863898	C	A	55863898	4	1	48	1	0	0	0	0	0	1	0	0	11243	922	32	2	915	2	OR6C70	12	55863898	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	836908	55863898	77987997	2887	7281										
OR10P1	121130	broad.mit.edu	37	chr12	56031002	56031002	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacgtcttcattgtcctgggCatctcggagtgctgcctgct	11	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:56031002C>T	ENST00000309675.2	+	1	359	c.327C>T	c.(325-327)ggC>ggT	p.G109G		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						TTGTCCTGGGCATCTCGGAGT	0.617													19	40					0	0	1	0	0	T	56031002	C	T	56031002	2	4	48	1	0	0	0	0	0	0	0	1	10962	697	25	3		3	OR10P1	12	56031002	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	167104	56031002	77820893	2888	7282										
OR10P1	121130	broad.mit.edu	37	chr12	56031269	56031269	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggaagcacaggagcgagatCtccgtgatgacagccaccat	13	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:56031269C>A	ENST00000309675.2	+	1	626	c.594C>A	c.(592-594)atC>atA	p.I198I		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						GGAGCGAGATCTCCGTGATGA	0.537													52	79					1.07234e-20	1.47176e-20	1	1	0	A	56031269	C	A	56031269	2	1	48	1	0	0	0	0	0	0	0	1	10962	903	32	2		2	OR10P1	12	56031269	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	267	56031269	77820626	2889	7283										
GDF11	0	broad.mit.edu	37	chr12	56143605	56143605	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgctctacttcaatgacaAgcagcagattatctacggca	7	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:56143605A>G	ENST00000257868.5	+	3	1200	c.1163A>G	c.(1162-1164)aAg>aGg	p.K388R		NM_005811.3	NP_005802.1	O95390	GDF11_HUMAN	growth differentiation factor 11	388					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|urinary_tract(1)	12						TTCAATGACAAGCAGCAGATT	0.557													20	182					0	0	1	0	0	G	56143605	A	G	56143605	3	3	48	1	0	0	0	0	1	0	0	0	6353	72	3	4	1173	4	GDF11	12	56143605	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	112336	56143605	77708290	2890	7284										
DGKA	1606	broad.mit.edu	37	chr12	56331252	56331252	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctcgaagtggataatgttCccagacacctaagcctggca	9	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:56331252C>A	ENST00000331886.5	+	4	653	c.199C>A	c.(199-201)Ccc>Acc	p.P67T	DGKA_ENST00000394147.1_Missense_Mutation_p.P67T|DGKA_ENST00000551156.1_Missense_Mutation_p.P67T	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	67					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	GGATAATGTTCCCAGACACCT	0.463													7	84					0.000157383	0.000169016	1	1	0	A	56331252	C	A	56331252	3	1	48	1	0	0	0	0	1	0	0	0	4493	855	30	2	209	2	DGKA	12	56331252	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	187647	56331252	77520643	2891	7285										
MYL6	4637	broad.mit.edu	37	chr12	56554045	56554045	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtgagaagatgacagaggAagaagtagagatgctggtgg	18	2	0	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:56554045A>G	ENST00000551589.1	+	5	401	c.368A>G	c.(367-369)gAa>gGa	p.E123G	MYL6_ENST00000547408.1_Missense_Mutation_p.E123G|MYL6_ENST00000550697.1_Missense_Mutation_p.E123G|MYL6_ENST00000547649.1_Missense_Mutation_p.E123G|MYL6_ENST00000536128.1_Missense_Mutation_p.E216G|MYL6_ENST00000549566.1_Missense_Mutation_p.E168G|MYL6_ENST00000293422.5_Missense_Mutation_p.E124G|MYL6_ENST00000548580.1_Missense_Mutation_p.E75G|MYL6_ENST00000548293.1_Missense_Mutation_p.E123G|MYL6_ENST00000548400.1_Missense_Mutation_p.E87G|MYL6_ENST00000549017.1_Missense_Mutation_p.E19G|MYL6_ENST00000348108.4_Missense_Mutation_p.E124G			P60660	MYL6_HUMAN	myosin, light chain 6, alkali, smooth muscle and non-muscle	123	EF-hand 3.				axon guidance|muscle filament sliding|skeletal muscle tissue development	cytosol|unconventional myosin complex	actin-dependent ATPase activity|calcium ion binding|motor activity|structural constituent of muscle			large_intestine(1)|lung(1)|ovary(1)|prostate(3)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			ATGACAGAGGAAGAAGTAGAG	0.488													20	40					0	0	1	0	0	G	56554045	A	G	56554045	3	3	48	1	0	0	0	0	1	0	0	0	10098	246	9	4	386	4	MYL6	12	56554045	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	222793	56554045	77297850	2892	7286										
ATP5B	506	broad.mit.edu	37	chr12	57039021	57039021	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacttccagggcatttagaaTtggtggtagtccctcatcaa	9	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57039021T>C	ENST00000262030.3	-	2	294	c.244A>G	c.(244-246)Att>Gtt	p.I82V	ATP5B_ENST00000552919.1_Missense_Mutation_p.I82V	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	82					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCATTTAGAATTGGTGGTAGT	0.542													14	78					0	0	1	0	0	C	57039021	T	C	57039021	3	2	48	1	0	0	0	0	1	0	0	0	1147	1493	52	4	1381	4	ATP5B	12	57039021	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	484976	57039021	76812874	2893	7287										
NACA	4666	broad.mit.edu	37	chr12	57114403	57114403	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcaagatgagagcccagaGaaatgggaaaatctgggggg	17	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57114403G>T	ENST00000454682.1	-	3	1192	c.911C>A	c.(910-912)tCt>tAt	p.S304Y	NACA_ENST00000550952.1_Missense_Mutation_p.S304Y|NACA_ENST00000356769.3_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000552540.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						AGAGCCCAGAGAAATGGGAAA	0.483			T	BCL6	NHL								25	33					9.57634e-11	1.18295e-10	1	1	0	T	57114403	G	T	57114403	3	4	48	1	0	0	0	0	1	0	0	0	10180	942	33	2	5353	2	NACA	12	57114403	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	75382	57114403	76737492	2894	7288										
MYO1A	4640	broad.mit.edu	37	chr12	57431423	57431423	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggaccttctcaacacctTccctatggaagcaaatgaca	6	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57431423T>C	ENST00000442789.2	-	20	2251	c.1964A>G	c.(1963-1965)gAa>gGa	p.E655G	MYO1A_ENST00000544473.1_Missense_Mutation_p.E493G|MYO1A_ENST00000300119.3_Missense_Mutation_p.E655G	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	655	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						CTCAACACCTTCCCTATGGAA	0.507													85	157					0	0	1	0	0	C	57431423	T	C	57431423	3	2	48	1	0	0	0	0	1	0	0	0	10115	1783	62	4	1207	4	MYO1A	12	57431423	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	317020	57431423	76420472	2895	7289										
LRP1	4035	broad.mit.edu	37	chr12	57588394	57588394	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgccctctgaattacttCgcctgccctagtgggcgctg	11	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57588394C>T	ENST00000243077.3	+	50	8569	c.8103C>T	c.(8101-8103)ttC>ttT	p.F2701F		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2701	LDL-receptor class A 15.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity	p.F2701F(2)		NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGAATTACTTCGCCTGCCCTA	0.632													43	53					0	0	1	0	0	T	57588394	C	T	57588394	2	4	48	1	0	0	0	0	0	0	0	1	8995	883	31	1		1	LRP1	12	57588394	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	156971	57588394	76263501	2896	7290										
STAC3	246329	broad.mit.edu	37	chr12	57642498	57642498	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcctactcacgatcttgccGaagcatctctgcatttccac	6	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57642498G>A	ENST00000332782.2	-	4	624	c.423C>T	c.(421-423)ttC>ttT	p.F141F	STAC3_ENST00000554578.1_Silent_p.F102F|STAC3_ENST00000546246.2_Intron	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	141					intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						CGATCTTGCCGAAGCATCTCT	0.542													192	364					0	0	1	0	0	A	57642498	G	A	57642498	2	1	48	1	0	0	0	0	0	0	0	1	15296	1049	37	1		1	STAC3	12	57642498	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	54104	57642498	76209397	2897	7291										
GLI1	2735	broad.mit.edu	37	chr12	57865362	57865362	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgctaaagctccagtgaacAcatatggacctggctttgga	11	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57865362A>G	ENST00000228682.2	+	12	2930	c.2839A>G	c.(2839-2841)Aca>Gca	p.T947A	GLI1_ENST00000543426.1_Missense_Mutation_p.T819A|GLI1_ENST00000546141.1_Missense_Mutation_p.T906A	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	947					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TCCAGTGAACACATATGGACC	0.547													32	59					0	0	1	0	0	G	57865362	A	G	57865362	3	3	48	1	0	0	0	0	1	0	0	0	6478	159	6	4	2881	4	GLI1	12	57865362	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	222864	57865362	75986533	2898	7292										
ARHGAP9	64333	broad.mit.edu	37	chr12	57867888	57867888	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggctggggcagctcccggaGaaaaagcttcagggctccgg	16	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57867888G>T	ENST00000393797.2	-	19	2317	c.2125C>A	c.(2125-2127)Ctc>Atc	p.L709I	ARHGAP9_ENST00000356411.2_Missense_Mutation_p.L638I|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.L435I|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.L698I|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.L619I|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.L619I			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	638	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			AGCTCCCGGAGAAAAAGCTTC	0.562													15	22					3.45872e-05	3.78815e-05	1	1	0	T	57867888	G	T	57867888	3	4	48	1	0	0	0	0	1	0	0	0	886	942	33	2	352	2	ARHGAP9	12	57867888	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2526	57867888	75984007	2899	7293										
DDIT3	1649	broad.mit.edu	37	chr12	57910667	57910667	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttccctggtcaggcgctcGatttcctgcttgagccgttc	10	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:57910667G>A	ENST00000551116.1	-	4	771	c.504C>T	c.(502-504)atC>atT	p.I168I	DDIT3_ENST00000552740.1_Silent_p.I168I|DDIT3_ENST00000346473.3_Silent_p.I145I|DDIT3_ENST00000547303.1_Silent_p.I145I	NM_001195053.1|NM_001195054.1|NM_001195055.1|NM_001195056.1	NP_001181982.1|NP_001181983.1|NP_001181984.1|NP_001181985.1	P35638	DDIT3_HUMAN	DNA-damage-inducible transcript 3	145					cell cycle arrest|cell redox homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of determination of dorsal identity|regulation of DNA-dependent transcription in response to stress|response to DNA damage stimulus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding		EWSR1/DDIT3(45)|FUS/DDIT3(631)	central_nervous_system(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)|skin(1)	16						TCAGGCGCTCGATTTCCTGCT	0.542			T	FUS	liposarcoma								40	96					0	0	1	0	0	A	57910667	G	A	57910667	2	1	48	1	0	0	0	0	0	0	0	1	4353	1048	37	1		1	DDIT3	12	57910667	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42779	57910667	75941228	2900	7294										
DTX3	196403	broad.mit.edu	37	chr12	58002452	58002452	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcggcacgtccatgaccacAgggagaccgaatgtcatcac	10	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:58002452A>C	ENST00000548198.1	+	4	2404	c.900A>C	c.(898-900)acA>acC	p.T300T	DTX3_ENST00000548804.1_Silent_p.T300T|DTX3_ENST00000551632.1_Silent_p.T303T|DTX3_ENST00000337737.3_Silent_p.T300T			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	300					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					CCATGACCACAGGGAGACCGA	0.597													10	25					0	0	1	0	0	C	58002452	A	C	58002452	2	2	48	1	0	0	0	0	0	0	0	1	4821	175	7	4		4	DTX3	12	58002452	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	91785	58002452	75849443	2901	7295										
AVIL	10677	broad.mit.edu	37	chr12	58197112	58197112	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatctcagtgacaacgaatTggccggtcttattggaacat	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:58197112T>C	ENST00000537081.1	-	15	1858	c.1859A>G	c.(1858-1860)cAa>cGa	p.Q620R	AVIL_ENST00000257861.3_Missense_Mutation_p.Q627R|AVIL_ENST00000550083.1_5'UTR|TSFM_ENST00000548851.1_Intron			O75366	AVIL_HUMAN	advillin	627	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GACAACGAATTGGCCGGTCTT	0.478											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	78					0	0	1	0	0	C	58197112	T	C	58197112	3	2	48	1	0	0	0	0	1	0	0	0	1225	1812	63	4	599	4	AVIL	12	58197112	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	194660	58197112	75654783	2902	7296										
AVIL	10677	broad.mit.edu	37	chr12	58209764	58209764	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagcccagctcacctctatTctccagacaatgatcccagg	6	17	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:58209764T>G	ENST00000257861.3	-	1	490	c.60A>C	c.(58-60)agA>agC	p.R20S		NM_006576.3	NP_006567.3	O75366	AVIL_HUMAN	advillin	20	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					TCACCTCTATTCTCCAGACAA	0.572													16	35					0	0	1	0	0	G	58209764	T	G	58209764	3	3	48	1	0	0	0	0	1	0	0	0	1225	1780	62	4	2475	4	AVIL	12	58209764	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	12652	58209764	75642131	2903	7297										
LRIG3	121227	broad.mit.edu	37	chr12	59274382	59274382	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatttactgtaagcttggcTttgacagagtaggatgaacc	10	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:59274382T>G	ENST00000320743.3	-	13	2068	c.1782A>C	c.(1780-1782)aaA>aaC	p.K594N	LRIG3_ENST00000379141.4_Missense_Mutation_p.K534N	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	594	Ig-like C2-type 1.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TAAGCTTGGCTTTGACAGAGT	0.393			T	ROS1	NSCLC								5	41					0	0	1	0	0	G	59274382	T	G	59274382	3	3	48	1	0	0	0	0	1	0	0	0	8990	1606	56	4	1605	4	LRIG3	12	59274382	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1064618	59274382	74577513	2904	7298										
SLC16A7	9194	broad.mit.edu	37	chr12	60098718	60098718	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtcaccgtattcttcaaaGaaattcagcaaatattccac	4	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:60098718G>T	ENST00000261187.4	+	2	300	c.136G>T	c.(136-138)Gaa>Taa	p.E46*	SLC16A7_ENST00000552432.1_Nonsense_Mutation_p.E46*|SLC16A7_ENST00000547379.1_Nonsense_Mutation_p.E46*|SLC16A7_ENST00000549465.1_Nonsense_Mutation_p.E46*|SLC16A7_ENST00000543448.1_5'UTR|SLC16A7_ENST00000552024.1_Nonsense_Mutation_p.E46*|SLC16A7_ENST00000549588.1_3'UTR	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	46						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATTCTTCAAAGAAATTCAGCA	0.423													4	41					0.00909568	0.00935351	1	1	0	T	60098718	G	T	60098718	4	4	48	1	0	0	0	0	0	1	0	0	14467	943	33	2	138	2	SLC16A7	12	60098718	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	824336	60098718	73753177	2905	7299										
MON2	23041	broad.mit.edu	37	chr12	62931428	62931428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggactttacttaacttggCgcattgccatggggctgttc	12	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:62931428C>T	ENST00000393630.3	+	16	2451	c.2060C>T	c.(2059-2061)gCg>gTg	p.A687V	MON2_ENST00000552115.1_Missense_Mutation_p.A687V|MON2_ENST00000393632.2_Missense_Mutation_p.A687V|MON2_ENST00000552738.1_Missense_Mutation_p.A664V|MON2_ENST00000393629.2_Missense_Mutation_p.A687V|MON2_ENST00000280379.6_Missense_Mutation_p.A687V|MON2_ENST00000546600.1_Missense_Mutation_p.A687V	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	687					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CTTAACTTGGCGCATTGCCAT	0.338													24	49					0	0	1	0	0	T	62931428	C	T	62931428	3	4	48	1	0	0	0	0	1	0	0	0	9748	768	27	1	2122	1	MON2	12	62931428	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2832710	62931428	70920467	2906	7300										
PPM1H	57460	broad.mit.edu	37	chr12	63182119	63182119	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcgttctatctgtaggtcCtggagaataaaacagagtta	9	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:63182119C>T	ENST00000228705.6	-	4	1057		c.e4-1			NM_020700.1	NP_065751.1	Q9ULR3	PPM1H_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1H								phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)	18			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		TCTGTAGGTCCTGGAGAATAA	0.438													6	10					0	0	1	0	0	T	63182119	C	T	63182119	5	4	48	1	0	0	0	0	0	0	1	0	12389	695	24	3	816	3	PPM1H	12	63182119	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	250691	63182119	70669776	2907	7301										
LEMD3	23592	broad.mit.edu	37	chr12	65639662	65639662	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgtgtatatgttaaatgtCtgtctccagaatatgctgga	10	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:65639662C>T	ENST00000308330.2	+	12	2541	c.2515C>T	c.(2515-2517)Ctg>Ttg	p.L839L		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	839	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		TGTTAAATGTCTGTCTCCAGA	0.299													22	53					0	0	1	0	0	T	65639662	C	T	65639662	2	4	48	1	0	0	0	0	0	0	0	1	8759	912	32	3		3	LEMD3	12	65639662	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2457543	65639662	68212233	2908	7302										
HELB	92797	broad.mit.edu	37	chr12	66709096	66709096	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgagactcttaagtcaagaAattgtgctattgagctaaag	9	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:66709096A>C	ENST00000247815.4	+	6	1992	c.1933A>C	c.(1933-1935)Aat>Cat	p.N645H		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	645					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TAAGTCAAGAAATTGTGCTAT	0.353													20	38					0	0	1	0	0	C	66709096	A	C	66709096	3	2	48	1	0	0	0	0	1	0	0	0	7085	14	1	4	1955	4	HELB	12	66709096	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1069434	66709096	67142799	2909	7303										
CAND1	55832	broad.mit.edu	37	chr12	67700159	67700159	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaataactagtcaacccaAaaggcagtatcttttacttc	5	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:67700159A>C	ENST00000545606.1	+	10	3148	c.2711A>C	c.(2710-2712)aAa>aCa	p.K904T		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	904					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AGTCAACCCAAAAGGCAGTAT	0.413													14	18					0	0	1	0	0	C	67700159	A	C	67700159	3	2	48	1	0	0	0	0	1	0	0	0	2633	14	1	4	2749	4	CAND1	12	67700159	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	991063	67700159	66151736	2910	7304										
DYRK2	8445	broad.mit.edu	37	chr12	68051084	68051084	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctggacagcattcatagaCggcaggggagctccacctct	12	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:68051084C>T	ENST00000344096.3	+	3	810	c.397C>T	c.(397-399)Cgg>Tgg	p.R133W	DYRK2_ENST00000393555.3_Missense_Mutation_p.R60W	NM_006482.2	NP_006473.2	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	133					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		CATTCATAGACGGCAGGGGAG	0.542													23	37					0	0	1	0	0	T	68051084	C	T	68051084	3	4	48	1	0	0	0	0	1	0	0	0	4882	527	19	1	407	1	DYRK2	12	68051084	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	350925	68051084	65800811	2911	7305										
NUP107	57122	broad.mit.edu	37	chr12	69084386	69084386	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgctcacgcactttaggttCtttctaccaaccttttgttt	5	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:69084386C>A	ENST00000539906.1	+	4	320	c.76C>A	c.(76-78)Ctt>Att	p.L26I	NUP107_ENST00000229179.4_Intron|NUP107_ENST00000378905.2_Intron			P57740	NU107_HUMAN	nucleoporin 107kDa	0					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			ACTTTAGGTTCTTTCTACCAA	0.378													20	40					1.00905e-13	1.29777e-13	1	1	0	A	69084386	C	A	69084386	3	1	48	1	0	0	0	0	1	0	0	0	10800	928	32	2		2	NUP107	12	69084386	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1033302	69084386	64767509	2912	7306										
NUP107	57122	broad.mit.edu	37	chr12	69096538	69096538	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagaatacagtctgcattaGaagaggaaagtgtattcgca	10	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:69096538G>T	ENST00000229179.4	+	8	1035	c.703G>T	c.(703-705)Gaa>Taa	p.E235*	NUP107_ENST00000539906.1_Nonsense_Mutation_p.E206*|NUP107_ENST00000378905.2_Nonsense_Mutation_p.E84*	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	235					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			GTCTGCATTAGAAGAGGAAAG	0.274													20	34					2.4624e-09	2.95225e-09	1	1	0	T	69096538	G	T	69096538	4	4	48	1	0	0	0	0	0	1	0	0	10800	943	33	2	733	2	NUP107	12	69096538	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	12152	69096538	64755357	2913	7307										
CPSF6	11052	broad.mit.edu	37	chr12	69650589	69650589	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taactccatgcaataaacagTtcctgagtcaatttgaaatg	6	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:69650589T>C	ENST00000435070.2	+	4	597	c.487T>C	c.(487-489)Ttc>Ctc	p.F163L	CPSF6_ENST00000456847.3_Missense_Mutation_p.F163L|CPSF6_ENST00000551516.1_Intron|CPSF6_ENST00000266679.8_Missense_Mutation_p.F163L	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	163					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CAATAAACAGTTCCTGAGTCA	0.358													18	43					0	0	1	0	0	C	69650589	T	C	69650589	3	2	48	1	0	0	0	0	1	0	0	0	3852	1725	60	4	501	4	CPSF6	12	69650589	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	554051	69650589	64201306	2914	7308										
FRS2	10818	broad.mit.edu	37	chr12	69968311	69968311	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgcaagctaagtagggatgAagatgacaatttaggaccaa	11	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:69968311A>T	ENST00000299293.2	+	10	1613	c.1103A>T	c.(1102-1104)gAa>gTa	p.E368V	FRS2_ENST00000397997.2_Missense_Mutation_p.E368V|FRS2_ENST00000550389.1_Missense_Mutation_p.E368V|FRS2_ENST00000549921.1_Missense_Mutation_p.E368V	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	368					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGTAGGGATGAAGATGACAAT	0.383													35	56					0	0	1	0	0	T	69968311	A	T	69968311	3	4	48	1	0	0	0	0	1	0	0	0	6095	246	9	4	1121	4	FRS2	12	69968311	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	317722	69968311	63883584	2915	7309										
BEST3	144453	broad.mit.edu	37	chr12	70048879	70048879	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatggggtctggacttagGtttcccagggaagtgtggct	15	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:70048879G>T	ENST00000330891.5	-	10	2041	c.1815C>A	c.(1813-1815)aaC>aaA	p.N605K	BEST3_ENST00000488961.1_Missense_Mutation_p.N392K|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Missense_Mutation_p.N499K	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	605						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CTGGACTTAGGTTTCCCAGGG	0.483													19	41					1.10923e-09	1.34134e-09	1	1	0	T	70048879	G	T	70048879	3	4	48	1	0	0	0	0	1	0	0	0	1404	1252	44	5	195	5	BEST3	12	70048879	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	80568	70048879	63803016	2916	7310										
RAB3IP	117177	broad.mit.edu	37	chr12	70149248	70149248	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgcttcacctacttctccGgaccttcttggtgtgtatga	8	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:70149248G>A	ENST00000550536.1	+	2	565	c.108G>A	c.(106-108)ccG>ccA	p.P36P	RAB3IP_ENST00000378815.6_Silent_p.P20P|RAB3IP_ENST00000362025.5_Silent_p.P36P|RAB3IP_ENST00000247833.7_Silent_p.P20P|RAB3IP_ENST00000483530.2_Silent_p.P20P|RAB3IP_ENST00000325555.9_5'UTR	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	36					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			CTACTTCTCCGGACCTTCTTG	0.443													22	43					0	0	1	0	0	A	70149248	G	A	70149248	2	1	48	1	0	0	0	0	0	0	0	1	12989	1103	39	1		1	RAB3IP	12	70149248	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	100369	70149248	63702647	2917	7311										
PTPRB	0	broad.mit.edu	37	chr12	70946656	70946656	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctgctccaagcttaatgTtaaaactcttggagttgctg	8	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:70946656T>C	ENST00000334414.6	-	21	5332	c.5288A>G	c.(5287-5289)aAc>aGc	p.N1763S	PTPRB_ENST00000550857.1_Missense_Mutation_p.N1455S|PTPRB_ENST00000550358.1_Missense_Mutation_p.N1675S|PTPRB_ENST00000538708.1_Missense_Mutation_p.N1455S|PTPRB_ENST00000261266.5_Missense_Mutation_p.N1545S|PTPRB_ENST00000451516.2_Missense_Mutation_p.N1455S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1545	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AAGCTTAATGTTAAAACTCTT	0.463													30	49					0	0	1	0	0	C	70946656	T	C	70946656	3	2	48	1	0	0	0	0	1	0	0	0	12847	1725	60	4	1415	4	PTPRB	12	70946656	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	797408	70946656	62905239	2918	7312										
PTPRR	5801	broad.mit.edu	37	chr12	71155283	71155283	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgtaattccaaactgggAtaaactttgatgcaaaacat	6	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:71155283A>G	ENST00000283228.2	-	4	1047	c.595T>C	c.(595-597)Tcc>Ccc	p.S199P	PTPRR_ENST00000342084.4_Missense_Mutation_p.S87P	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	199					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CCAAACTGGGATAAACTTTGA	0.383													20	68					0	0	1	0	0	G	71155283	A	G	71155283	3	3	48	1	0	0	0	0	1	0	0	0	12861	333	12	4	1422	4	PTPRR	12	71155283	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	208627	71155283	62696612	2919	7313										
TSPAN8	7103	broad.mit.edu	37	chr12	71523156	71523157	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccaataactataatcaaaINSttttttgccaagaagtcttt					rs139952436	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:71523156_71523157insT	ENST00000393330.2	-	11	1166_1167	c.614_615insA	c.(613-615)attfs	p.I205fs	TSPAN8_ENST00000552128.1_Frame_Shift_Ins_p.I122fs|TSPAN8_ENST00000546561.1_Frame_Shift_Ins_p.I205fs|TSPAN8_ENST00000247829.3_Frame_Shift_Ins_p.I205fs			P19075	TSN8_HUMAN	tetraspanin 8	205					protein glycosylation	integral to membrane|lysosome	signal transducer activity			breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			CTATAATCAAATTTTTTGCCAA	0.267													8	22	---	---	---	---						T	71523157	-	T	71523156	7	5	48	1	0	1	1	0	0	0	0	0	16713	98	4	0	106	0	TSPAN8	12	71523156	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	367873	71523156	62328739	2920	7314										
LGR5	8549	broad.mit.edu	37	chr12	71950416	71950416	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagacatctccataacaataGaatccactccctgggaaaga	6	12	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:71950416G>T	ENST00000266674.5	+	6	973	c.662G>T	c.(661-663)aGa>aTa	p.R221I	LGR5_ENST00000536515.1_Missense_Mutation_p.R149I|LGR5_ENST00000540815.2_Missense_Mutation_p.R221I			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	221						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CATAACAATAGAATCCACTCC	0.388													25	51					4.4004e-07	5.01286e-07	1	1	0	T	71950416	G	T	71950416	3	4	48	1	0	0	0	0	1	0	0	0	8796	942	33	2	684	2	LGR5	12	71950416	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	427260	71950416	61901479	2921	7315										
LGR5	8549	broad.mit.edu	37	chr12	71978130	71978130	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accaactgcatcctaaactgCcctgtggctttcttgtcctt	6	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:71978130C>T	ENST00000266674.5	+	18	2651	c.2340C>T	c.(2338-2340)tgC>tgT	p.C780C	LGR5_ENST00000540815.2_Silent_p.C756C|LGR5_ENST00000536515.1_Silent_p.C708C			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	780						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TCCTAAACTGCCCTGTGGCTT	0.428													37	86					0	0	1	0	0	T	71978130	C	T	71978130	2	4	48	1	0	0	0	0	0	0	0	1	8796	747	26	3		3	LGR5	12	71978130	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	27714	71978130	61873765	2922	7316										
ZFC3H1	196441	broad.mit.edu	37	chr12	72037952	72037952	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctgatttgagagatctcGaatttttctgatttcttcct	6	8	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:72037952G>A	ENST00000378743.3	-	5	1784	c.1426C>T	c.(1426-1428)Cga>Tga	p.R476*		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	476					RNA processing	intracellular	metal ion binding	p.R476*(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GAGAGATCTCGAATTTTTCTG	0.363													4	16					0	0	1	0	0	A	72037952	G	A	72037952	4	1	48	1	0	0	0	0	0	1	0	0	17690	1066	37	1	4667	1	ZFC3H1	12	72037952	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	59822	72037952	61813943	2923	7317										
TRHDE	29953	broad.mit.edu	37	chr12	72771853	72771853	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atataacaaagagattaataGaattttatgaagactacttt	5	3	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:72771853G>T	ENST00000261180.4	+	3	1228	c.1132G>T	c.(1132-1134)Gaa>Taa	p.E378*		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	378					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GAGATTAATAGAATTTTATGA	0.328													14	53					0.00400662	0.0041636	1	1	0	T	72771853	G	T	72771853	4	4	48	1	0	0	0	0	0	1	0	0	16539	943	33	2	1142	2	TRHDE	12	72771853	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	733901	72771853	61080042	2924	7318										
TRHDE	29953	broad.mit.edu	37	chr12	72955964	72955964	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggattatttaaccattcataAgtatggtaatgcagccagaa	8	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:72955964A>C	ENST00000261180.4	+	8	1769	c.1673A>C	c.(1672-1674)aAg>aCg	p.K558T	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	558					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						ACCATTCATAAGTATGGTAAT	0.269													6	11					0	0	1	0	0	C	72955964	A	C	72955964	3	2	48	1	0	0	0	0	1	0	0	0	16539	72	3	4	1703	4	TRHDE	12	72955964	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	184111	72955964	60895931	2925	7319										
KCNC2	3747	broad.mit.edu	37	chr12	75444659	75444659	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattcattagtactagctcGaagagtatgtccaagcaccc	7	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:75444659G>A	ENST00000549446.1	-	3	1806	c.1126C>T	c.(1126-1128)Cga>Tga	p.R376*	KCNC2_ENST00000550433.1_Nonsense_Mutation_p.R376*|KCNC2_ENST00000540018.1_Nonsense_Mutation_p.R376*|KCNC2_ENST00000548513.1_Nonsense_Mutation_p.R376*|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000393288.2_Nonsense_Mutation_p.R376*|KCNC2_ENST00000341669.3_Nonsense_Mutation_p.R376*|KCNC2_ENST00000298972.1_Nonsense_Mutation_p.R376*|KCNC2_ENST00000350228.2_Nonsense_Mutation_p.R376*	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	376					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R376*(2)		breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GTACTAGCTCGAAGAGTATGT	0.453													8	48					0	0	1	0	0	A	75444659	G	A	75444659	4	1	48	1	0	0	0	0	0	1	0	0	8058	1066	37	1	868	1	KCNC2	12	75444659	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2488695	75444659	58407236	2926	7320										
NAV3	89795	broad.mit.edu	37	chr12	78225316	78225316	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtgcatactgctcttccGataccaaatcttggcactac	6	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:78225316G>A	ENST00000397909.2	+	1	248	c.75G>A	c.(73-75)ccG>ccA	p.P25P	NAV3_ENST00000228327.6_Silent_p.P25P|NAV3_ENST00000266692.7_Silent_p.P25P|NAV3_ENST00000536525.2_Silent_p.P25P			Q8IVL0	NAV3_HUMAN	neuron navigator 3	25						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTGCTCTTCCGATACCAAATC	0.463										HNSCC(70;0.22)			58	121					0	0	1	0	0	A	78225316	G	A	78225316	2	1	48	1	0	0	0	0	0	0	0	1	10232	1045	37	1		1	NAV3	12	78225316	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2780657	78225316	55626579	2927	7321										
NAV3	89795	broad.mit.edu	37	chr12	78562559	78562559	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaacttatagaactaagaGaaaccattgaaatgctgaag	8	6	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:78562559G>T	ENST00000397909.2	+	24	5067	c.4894G>T	c.(4894-4896)Gaa>Taa	p.E1632*	NAV3_ENST00000228327.6_Nonsense_Mutation_p.E1632*|NAV3_ENST00000266692.7_Nonsense_Mutation_p.E1455*|NAV3_ENST00000536525.2_Nonsense_Mutation_p.E1632*			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1632						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGAACTAAGAGAAACCATTGA	0.403										HNSCC(70;0.22)			23	48					3.7963e-18	5.12524e-18	1	1	0	T	78562559	G	T	78562559	4	4	48	1	0	0	0	0	0	1	0	0	10232	943	33	2	4988	2	NAV3	12	78562559	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	337243	78562559	55289336	2928	7322										
NAV3	89795	broad.mit.edu	37	chr12	78582038	78582038	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttatttaggaccaaaaatCtcaggcatatttgataggat	7	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:78582038C>T	ENST00000397909.2	+	32	5974	c.5801C>T	c.(5800-5802)tCt>tTt	p.S1934F	NAV3_ENST00000552300.1_3'UTR|NAV3_ENST00000228327.6_Missense_Mutation_p.S1912F|NAV3_ENST00000266692.7_Missense_Mutation_p.S1735F|NAV3_ENST00000536525.2_Missense_Mutation_p.S1912F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1934						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GACCAAAAATCTCAGGCATAT	0.313										HNSCC(70;0.22)			19	26					0	0	1	0	0	T	78582038	C	T	78582038	3	4	48	1	0	0	0	0	1	0	0	0	10232	913	32	3	5857	3	NAV3	12	78582038	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19479	78582038	55269857	2929	7323										
SYT1	6857	broad.mit.edu	37	chr12	79679637	79679637	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgacctgctgcttttgtatCtgtaagaaatgtttgttcaa	8	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:79679637C>A	ENST00000261205.4	+	5	894	c.237C>A	c.(235-237)atC>atA	p.I79I	SYT1_ENST00000393240.3_Silent_p.I79I|SYT1_ENST00000457153.2_Silent_p.I79I|SYT1_ENST00000552744.1_Silent_p.I79I	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	79					detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						GCTTTTGTATCTGTAAGAAAT	0.403													15	42					1.49906e-05	1.64923e-05	1	1	0	A	79679637	C	A	79679637	2	1	48	1	0	0	0	0	0	0	0	1	15521	903	32	2		2	SYT1	12	79679637	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1097599	79679637	54172258	2930	7324										
PPFIA2	8499	broad.mit.edu	37	chr12	81741356	81741356	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttccctggcagggcttcGaggggtgagctttggagttg	16	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:81741356G>A	ENST00000550584.2	-	17	2483	c.2188C>T	c.(2188-2190)Cga>Tga	p.R730*	PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.R577*|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.R712*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.R730*|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000541570.2_Nonsense_Mutation_p.R297*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.R730*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.R730*|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.R631*|PPFIA2_ENST00000541017.1_Intron|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.R712*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.R656*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	656										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GCAGGGCTTCGAGGGGTGAGC	0.522													40	86					0	0	1	0	0	A	81741356	G	A	81741356	4	1	48	1	0	0	0	0	0	1	0	0	12354	1066	37	1	1645	1	PPFIA2	12	81741356	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2061719	81741356	52110539	2931	7325										
PPFIA2	8499	broad.mit.edu	37	chr12	81777837	81777837	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgatacttggtgttcatttCttctgttttaatgagatcct	7	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:81777837C>A	ENST00000550584.2	-	8	1244	c.949G>T	c.(949-951)Gaa>Taa	p.E317*	PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.E164*|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.E299*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.E317*|PPFIA2_ENST00000545296.2_5'UTR|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.E317*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.E317*|RP11-315E17.1_ENST00000546936.1_RNA|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.E218*|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.E299*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.E243*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	243										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GTGTTCATTTCTTCTGTTTTA	0.433													7	34					2.0095e-06	2.25447e-06	1	1	0	A	81777837	C	A	81777837	4	1	48	1	0	0	0	0	0	1	0	0	12354	922	32	2	2920	2	PPFIA2	12	81777837	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	36481	81777837	52074058	2932	7326										
SLC6A15	55117	broad.mit.edu	37	chr12	85285788	85285788	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggccatcaacaattagttCacttgtcttaaaagcatcat	5	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:85285788C>A	ENST00000450363.3	-	2	570	c.112G>T	c.(112-114)Gaa>Taa	p.E38*	SLC6A15_ENST00000551388.1_Intron|SLC6A15_ENST00000266682.5_Nonsense_Mutation_p.E38*|SLC6A15_ENST00000552192.1_Intron	NM_018057.6	NP_060527.2	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	38					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						ACAATTAGTTCACTTGTCTTA	0.383													21	126					1.01871e-10	1.25646e-10	1	1	0	A	85285788	C	A	85285788	4	1	48	1	0	0	0	0	0	1	0	0	14732	835	29	2	2238	2	SLC6A15	12	85285788	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3507951	85285788	48566107	2933	7327										
LRRIQ1	84125	broad.mit.edu	37	chr12	85439838	85439838	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagaatttatgagaagtaAaaccgattgtgccactcctg	9	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:85439838A>C	ENST00000393217.2	+	5	438	c.377A>C	c.(376-378)aAa>aCa	p.K126T		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	126										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ATGAGAAGTAAAACCGATTGT	0.348													17	23					0	0	1	0	0	C	85439838	A	C	85439838	3	2	48	1	0	0	0	0	1	0	0	0	9073	14	1	4	391	4	LRRIQ1	12	85439838	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	154050	85439838	48412057	2934	7328										
LRRIQ1	84125	broad.mit.edu	37	chr12	85449618	85449618	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaggataaaagaagagagAaaaaagcaaaaggaagagga	12	2	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:85449618A>G	ENST00000393217.2	+	8	1108	c.1047A>G	c.(1045-1047)agA>agG	p.R349R		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	349	Glu-rich.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		aagaagagagaaaaaagcaaa	0.343													4	11					0	0	1	0	0	G	85449618	A	G	85449618	2	3	48	1	0	0	0	0	0	0	0	1	9073	243	9	4		4	LRRIQ1	12	85449618	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	9780	85449618	48402277	2935	7329										
LRRIQ1	84125	broad.mit.edu	37	chr12	85450583	85450583	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataaatatagaaggcaaaaGaaatgaccaagattatgtgt	9	3	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:85450583G>T	ENST00000393217.2	+	8	2073	c.2012G>T	c.(2011-2013)aGa>aTa	p.R671I		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	671										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GAAGGCAAAAGAAATGACCAA	0.363													14	32					4.36969e-10	5.32873e-10	1	1	0	T	85450583	G	T	85450583	3	4	48	1	0	0	0	0	1	0	0	0	9073	942	33	2	2038	2	LRRIQ1	12	85450583	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	965	85450583	48401312	2936	7330										
ALX1	8092	broad.mit.edu	37	chr12	85677427	85677427	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatggacaactgtaacagtCtccgaatgtctcccgtgaaa	8	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:85677427C>T	ENST00000316824.3	+	2	459	c.304C>T	c.(304-306)Ctc>Ttc	p.L102F		NM_006982.2	NP_008913.2	Q15699	ALX1_HUMAN	ALX homeobox 1	102					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|ovary(1)	26				GBM - Glioblastoma multiforme(134;0.134)		CTGTAACAGTCTCCGAATGTC	0.468													30	59					0	0	1	0	0	T	85677427	C	T	85677427	3	4	48	1	0	0	0	0	1	0	0	0	552	913	32	3	310	3	ALX1	12	85677427	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	226844	85677427	48174468	2937	7331										
ALX1	8092	broad.mit.edu	37	chr12	85680696	85680696	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatggccaaatacaacaagcGaaaagccattttgctgccac	7	11	0	0	rs79907632	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:85680696G>A	ENST00000316824.3	+	3	752	c.597G>A	c.(595-597)gcG>gcA	p.A199A		NM_006982.2	NP_008913.2	Q15699	ALX1_HUMAN	ALX homeobox 1	199					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|ovary(1)	26				GBM - Glioblastoma multiforme(134;0.134)		TACAACAAGCGAAAAGCCATT	0.368													16	26					0	0	1	0	0	A	85680696	G	A	85680696	2	1	48	1	0	0	0	0	0	0	0	1	552	1045	37	1		1	ALX1	12	85680696	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3269	85680696	48171199	2938	7332										
NTS	4922	broad.mit.edu	37	chr12	86276047	86276047	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaaatgacaaaaatggaaAggaagaagtcataaagagaa	11	2	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:86276047A>C	ENST00000256010.6	+	4	514	c.407A>C	c.(406-408)aAg>aCg	p.K136T	NTS_ENST00000551529.1_Missense_Mutation_p.K61T	NM_006183.4	NP_006174.1	P30990	NEUT_HUMAN	neurotensin	136					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity			large_intestine(2)|lung(6)	8						AAAAATGGAAAGGAAGAAGTC	0.318													16	35					0	0	1	0	0	C	86276047	A	C	86276047	3	2	48	1	0	0	0	0	1	0	0	0	10756	72	3	4	421	4	NTS	12	86276047	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	595351	86276047	47575848	2939	7333										
MGAT4C	25834	broad.mit.edu	37	chr12	86383317	86383317	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgtttcatttgatgaaatTtaaacattctcttctgtgga	6	5	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:86383317T>G	ENST00000604798.1	-	6	1212	c.8A>C	c.(7-9)aAa>aCa	p.K3T	MGAT4C_ENST00000549405.2_Missense_Mutation_p.K3T|MGAT4C_ENST00000393205.2_Missense_Mutation_p.K32T|MGAT4C_ENST00000552808.2_Missense_Mutation_p.K3T|MGAT4C_ENST00000548651.1_Missense_Mutation_p.K3T|MGAT4C_ENST00000332156.1_Missense_Mutation_p.K3T|MGAT4C_ENST00000552435.2_Missense_Mutation_p.K3T			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	3					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						TTGATGAAATTTAAACATTCT	0.318													9	16					0	0	1	0	0	G	86383317	T	G	86383317	3	3	48	1	0	0	0	0	1	0	0	0	9596	1841	64	4	1440	4	MGAT4C	12	86383317	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	107270	86383317	47468578	2940	7334										
CEP290	80184	broad.mit.edu	37	chr12	88465107	88465107	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattttctaagtcaagatttCtcttttttaattcttccaat	2	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:88465107C>A	ENST00000552810.1	-	43	6318	c.5975G>T	c.(5974-5976)aGa>aTa	p.R1992I	CEP290_ENST00000547691.2_Missense_Mutation_p.R1052I|CEP290_ENST00000397838.3_Missense_Mutation_p.R1052I|CEP290_ENST00000309041.7_Missense_Mutation_p.R1994I	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1992					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						GTCAAGATTTCTCTTTTTTAA	0.348													13	18					0.000151284	0.00016287	1	1	0	A	88465107	C	A	88465107	3	1	48	1	0	0	0	0	1	0	0	0	3275	913	32	2	1512	2	CEP290	12	88465107	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2081790	88465107	45386788	2941	7335										
TMTC3	160418	broad.mit.edu	37	chr12	88542259	88542259	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactttatttcaaaatgactTctggggaacccctatgtctg	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:88542259T>C	ENST00000266712.6	+	2	387	c.167T>C	c.(166-168)tTc>tCc	p.F56S		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	56						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						CAAAATGACTTCTGGGGAACC	0.313													10	15					0	0	1	0	0	C	88542259	T	C	88542259	3	2	48	1	0	0	0	0	1	0	0	0	16321	1783	62	4	169	4	TMTC3	12	88542259	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	77152	88542259	45309636	2942	7336										
KITLG	4254	broad.mit.edu	37	chr12	88910206	88910206	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatggatctattaaaaattCtaaagaattcttcaggagta	6	5	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:88910206C>A	ENST00000347404.5	-	5	997	c.425G>T	c.(424-426)aGa>aTa	p.R142I	KITLG_ENST00000378535.4_5'UTR|KITLG_ENST00000228280.5_Missense_Mutation_p.R142I|KITLG_ENST00000357116.4_Intron	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	142					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						ATTAAAAATTCTAAAGAATTC	0.343									Testicular Cancer, Familial Clustering of				14	37					1.36491e-13	1.75346e-13	1	1	0	A	88910206	C	A	88910206	3	1	48	1	0	0	0	0	1	0	0	0	8372	913	32	2	416	2	KITLG	12	88910206	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	367947	88910206	44941689	2943	7337										
ATP2B1	490	broad.mit.edu	37	chr12	89992944	89992944	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacaagatttggccacgccGcaactccctttcagcgtgat	8	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:89992944G>A	ENST00000428670.3	-	20	3757	c.3301C>T	c.(3301-3303)Cgg>Tgg	p.R1101W	ATP2B1_ENST00000359142.3_Missense_Mutation_p.R1101W|ATP2B1_ENST00000348959.3_Missense_Mutation_p.R1065W|ATP2B1_ENST00000393164.2_Missense_Mutation_p.R844W|ATP2B1_ENST00000261173.2_Missense_Mutation_p.R1101W			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	1101	Calmodulin-binding subdomain A.				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						TGGCCACGCCGCAACTCCCTT	0.473													16	93					0	0	1	0	0	A	89992944	G	A	89992944	3	1	48	1	0	0	0	0	1	0	0	0	1138	1086	38	1	527	1	ATP2B1	12	89992944	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1082738	89992944	43858951	2944	7338										
KERA	11081	broad.mit.edu	37	chr12	91449541	91449541	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccactaatttgttgttctgtAggtcaagaagggtcaggttc	11	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:91449541A>C	ENST00000266719.3	-	2	765	c.518T>G	c.(517-519)cTa>cGa	p.L173R		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	173					response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						GTTGTTCTGTAGGTCAAGAAG	0.403													9	111					0	0	1	0	0	C	91449541	A	C	91449541	3	2	48	1	0	0	0	0	1	0	0	0	8185	420	15	4	548	4	KERA	12	91449541	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1456597	91449541	42402354	2945	7339										
LUM	4060	broad.mit.edu	37	chr12	91502546	91502546	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggttattcctaaggtaaaGatacttgattccaggaggca	10	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:91502546G>T	ENST00000266718.4	-	2	665	c.211C>A	c.(211-213)Ctt>Att	p.L71I	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	71					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CTAAGGTAAAGATACTTGATT	0.413													4	38					1	1	1	1	0	T	91502546	G	T	91502546	3	4	48	1	0	0	0	0	1	0	0	0	9129	942	33	2	813	2	LUM	12	91502546	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53005	91502546	42349349	2946	7340										
CLLU1OS	574016	broad.mit.edu	37	chr12	92821901	92821901	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttaaggcattccttaagttCgttgtgccccaatttgttca	7	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:92821901C>T	ENST00000378487.2	-	1	23	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	CLLU1_ENST00000472839.2_Intron|RP11-693J15.4_ENST00000508671.1_RNA|CLLU1_ENST00000378485.1_Intron|CLLU1OS_ENST00000538965.1_Missense_Mutation_p.E8K	NM_001025232.1	NP_001020403.1	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1 opposite strand	8										large_intestine(1)|lung(7)	8						tccttaagttcgttgtgcccc	0.423													16	24					0	0	1	0	0	T	92821901	C	T	92821901	3	4	48	1	0	0	0	0	1	0	0	0	3564	893	31	1	295	1	CLLU1OS	12	92821901	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1319355	92821901	41029994	2947	7341										
C12orf74	338809	broad.mit.edu	37	chr12	93100661	93100661	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggcttcccatgttacctttCgaagagcctgccaggaagcc	11	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:93100661C>A	ENST00000544406.2	+	2	520	c.254C>A	c.(253-255)tCg>tAg	p.S85*	C12orf74_ENST00000397833.3_Nonsense_Mutation_p.S85*			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	85										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						TGTTACCTTTCGAAGAGCCTG	0.562													21	60					1.2644e-06	1.4261e-06	1	1	0	A	93100661	C	A	93100661	4	1	48	1	0	0	0	0	0	1	0	0	1720	893	31	2	256	2	C12orf74	12	93100661	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	278760	93100661	40751234	2948	7342										
PLEKHG7	440107	broad.mit.edu	37	chr12	93150140	93150140	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccaaccagcagacaccttCtctatgaaggaaaattaact	5	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:93150140C>T	ENST00000344636.3	+	8	857	c.673C>T	c.(673-675)Ctc>Ttc	p.L225F		NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	225	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						CAGACACCTTCTCTATGAAGG	0.363													19	34					0	0	1	0	0	T	93150140	C	T	93150140	3	4	48	1	0	0	0	0	1	0	0	0	12122	913	32	3	699	3	PLEKHG7	12	93150140	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	49479	93150140	40701755	2949	7343										
PLEKHG7	440107	broad.mit.edu	37	chr12	93163929	93163929	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagtcaggaaaccaagaaAatatctttattcacattgcc	6	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:93163929A>C	ENST00000344636.3	+	12	1282	c.1098A>C	c.(1096-1098)aaA>aaC	p.K366N		NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	366					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						AAACCAAGAAAATATCTTTAT	0.318													24	45					0	0	1	0	0	C	93163929	A	C	93163929	3	2	48	1	0	0	0	0	1	0	0	0	12122	11	1	4	1140	4	PLEKHG7	12	93163929	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	13789	93163929	40687966	2950	7344										
EEA1	8411	broad.mit.edu	37	chr12	93169899	93169899	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagatatttccacactgtCggcagtgatgctgtaaatga	10	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:93169899C>T	ENST00000322349.8	-	29	4388	c.4124G>A	c.(4123-4125)cGa>cAa	p.R1375Q		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	1375					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						TCCACACTGTCGGCAGTGATG	0.358													9	28					0	0	1	0	0	T	93169899	C	T	93169899	3	4	48	1	0	0	0	0	1	0	0	0	4947	884	31	1	115	1	EEA1	12	93169899	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5970	93169899	40681996	2951	7345										
NUDT4	11163	broad.mit.edu	37	chr12	93792607	93792607	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtcactgaaatattagaaGattgggaagattctgttaat	9	4	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:93792607G>A	ENST00000337179.5	+	4	759	c.319G>A	c.(319-321)Gat>Aat	p.D107N	NUDT4_ENST00000547014.1_Missense_Mutation_p.D55N|NUDT4_ENST00000415493.2_Missense_Mutation_p.D106N|NUDT4_ENST00000548662.1_Missense_Mutation_p.D54N|NUDT4_ENST00000549992.1_Missense_Mutation_p.D54N	NM_199040.2	NP_950241.1	Q9NZJ9	NUDT4_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 4	106	Nudix hydrolase.				calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding			endometrium(2)|kidney(1)|lung(2)	5						AATATTAGAAGATTGGGAAGA	0.323													8	21					0	0	1	0	0	A	93792607	G	A	93792607	3	1	48	1	0	0	0	0	1	0	0	0	10788	942	33	3	333	3	NUDT4	12	93792607	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	622708	93792607	40059288	2952	7346										
SOCS2	8835	broad.mit.edu	37	chr12	93968612	93968612	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agactacctactaacaatatCtgttaaaacatcagctggac	5	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:93968612C>A	ENST00000340600.2	+	3	852	c.254C>A	c.(253-255)tCt>tAt	p.S85Y	SOCS2_ENST00000536696.2_Missense_Mutation_p.S85Y|SOCS2_ENST00000548537.1_3'UTR|SOCS2_ENST00000549206.1_Missense_Mutation_p.S85Y|SOCS2_ENST00000549122.1_Missense_Mutation_p.S85Y|SOCS2_ENST00000551556.1_Missense_Mutation_p.S85Y	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	85	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity	p.S85C(1)		cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						CTAACAATATCTGTTAAAACA	0.363													20	30					8.34094e-07	9.42356e-07	1	1	0	A	93968612	C	A	93968612	3	1	48	1	0	0	0	0	1	0	0	0	14967	913	32	2	260	2	SOCS2	12	93968612	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	176005	93968612	39883283	2953	7347										
CRADD	8738	broad.mit.edu	37	chr12	94243956	94243956	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcatccgttggcggcagcGcttcgggaagcaggccacct	13	14	1	0	rs141179774	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:94243956G>A	ENST00000542893.2	+	3	827	c.509G>A	c.(508-510)cGc>cAc	p.R170H	CRADD_ENST00000332896.3_Missense_Mutation_p.R170H|CRADD_ENST00000548483.1_Intron|CRADD_ENST00000541813.1_Intron|CRADD_ENST00000548330.1_3'UTR			P78560	CRADD_HUMAN	CASP2 and RIPK1 domain containing adaptor with death domain	170	Death.				apoptosis|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|signal transduction	intracellular	death domain binding|protease binding|protein binding, bridging			endometrium(1)|large_intestine(5)|lung(1)|ovary(1)	8						TGGCGGCAGCGCTTCGGGAAG	0.637													24	41					0	0	1	0	0	A	94243956	G	A	94243956	3	1	48	1	0	0	0	0	1	0	0	0	3868	1087	38	1	515	1	CRADD	12	94243956	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	275344	94243956	39607939	2954	7348										
PLXNC1	10154	broad.mit.edu	37	chr12	94543462	94543462	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacttcgtggacgcctttCtctggaacggcagcatctac	10	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:94543462C>T	ENST00000258526.4	+	1	964	c.715C>T	c.(715-717)Ctc>Ttc	p.L239F		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	239	Sema.				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GGACGCCTTTCTCTGGAACGG	0.687													9	11					0	0	1	0	0	T	94543462	C	T	94543462	3	4	48	1	0	0	0	0	1	0	0	0	12173	913	32	3	717	3	PLXNC1	12	94543462	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	299506	94543462	39308433	2955	7349										
PLXNC1	10154	broad.mit.edu	37	chr12	94575310	94575310	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttttctacaaactcgttcCtgatcctgtgaagaatatct	6	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:94575310C>A	ENST00000258526.4	+	3	1541	c.1292C>A	c.(1291-1293)cCt>cAt	p.P431H	RP11-74K11.2_ENST00000550759.1_RNA	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	431	Sema.				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AAACTCGTTCCTGATCCTGTG	0.308													27	56					1.50538e-07	1.73672e-07	1	1	0	A	94575310	C	A	94575310	3	1	48	1	0	0	0	0	1	0	0	0	12173	681	24	5	1302	5	PLXNC1	12	94575310	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31848	94575310	39276585	2956	7350										
PLXNC1	10154	broad.mit.edu	37	chr12	94692488	94692488	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagctccatttgctataaaAtacttttttgactttttgga	6	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:94692488A>C	ENST00000258526.4	+	27	4404	c.4155A>C	c.(4153-4155)aaA>aaC	p.K1385N	PLXNC1_ENST00000547057.1_Missense_Mutation_p.K432N|PLXNC1_ENST00000545312.1_Missense_Mutation_p.K124N	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1385					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TTGCTATAAAATACTTTTTTG	0.378													8	27					0	0	1	0	0	C	94692488	A	C	94692488	3	2	48	1	0	0	0	0	1	0	0	0	12173	98	4	4	4261	4	PLXNC1	12	94692488	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	117178	94692488	39159407	2957	7351										
CCDC41	51134	broad.mit.edu	37	chr12	94703807	94703807	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaaccaaaattagacttcGaaattcattatgtcttctct	5	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:94703807G>A	ENST00000397809.5	-	16	2437	c.1888C>T	c.(1888-1890)Cga>Tga	p.R630*	CCDC41_ENST00000339839.5_Nonsense_Mutation_p.R630*	NM_016122.2	NP_057206.2	Q9Y592	CCD41_HUMAN	coiled-coil domain containing 41	622										breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						ATTAGACTTCGAAATTCATTA	0.348													6	56					0	0	1	0	0	A	94703807	G	A	94703807	4	1	48	1	0	0	0	0	0	1	0	0	2832	1066	37	1	225	1	CCDC41	12	94703807	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11319	94703807	39148088	2958	7352										
NR2C1	7181	broad.mit.edu	37	chr12	95461145	95461145	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aataatttgatgtgcaatttCttctatggttgccatgatct	7	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:95461145C>A	ENST00000333003.5	-	2	346	c.16G>T	c.(16-18)Gaa>Taa	p.E6*	NR2C1_ENST00000545833.1_5'UTR|NR2C1_ENST00000393101.3_Nonsense_Mutation_p.E6*|NR2C1_ENST00000330677.7_Nonsense_Mutation_p.E6*	NM_003297.3	NP_003288.2	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	6	Required for interaction with KAT2B (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13						TGTGCAATTTCTTCTATGGTT	0.313													14	25					0.000151284	0.00016287	1	1	0	A	95461145	C	A	95461145	4	1	48	1	0	0	0	0	0	1	0	0	10669	922	32	2	1925	2	NR2C1	12	95461145	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	757338	95461145	38390750	2959	7353										
FGD6	55785	broad.mit.edu	37	chr12	95483391	95483391	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgtttcctccctgatggaAtgctatgtaagactgatgat	9	8	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:95483391A>G	ENST00000343958.4	-	18	4155	c.3932T>C	c.(3931-3933)aTt>aCt	p.I1311T	FGD6_ENST00000546711.1_Missense_Mutation_p.I1311T	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1311					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						CCCTGATGGAATGCTATGTAA	0.403													28	50					0	0	1	0	0	G	95483391	A	G	95483391	3	3	48	1	0	0	0	0	1	0	0	0	5869	101	4	4	376	4	FGD6	12	95483391	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	22246	95483391	38368504	2960	7354										
FGD6	55785	broad.mit.edu	37	chr12	95531303	95531303	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatagtagcaaatacctcaaAttctctaacaacagcagcaa	5	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:95531303A>G	ENST00000343958.4	-	7	3212	c.2989T>C	c.(2989-2991)Ttt>Ctt	p.F997L	FGD6_ENST00000549499.1_Missense_Mutation_p.F997L|FGD6_ENST00000546711.1_Missense_Mutation_p.F997L	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	997	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						AATACCTCAAATTCTCTAACA	0.328													26	35					0	0	1	0	0	G	95531303	A	G	95531303	3	3	48	1	0	0	0	0	1	0	0	0	5869	101	4	4	1363	4	FGD6	12	95531303	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	47912	95531303	38320592	2961	7355										
METAP2	10988	broad.mit.edu	37	chr12	95868101	95868101	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaagagcaaagggccttCtgcaggtaaagagagtttta	13	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:95868101C>A	ENST00000323666.5	+	1	375	c.146C>A	c.(145-147)tCt>tAt	p.S49Y	METAP2_ENST00000261220.9_Missense_Mutation_p.S49Y|METAP2_ENST00000546753.1_Missense_Mutation_p.S49Y|METAP2_ENST00000551840.1_Missense_Mutation_p.S49Y|METAP2_ENST00000550777.1_Missense_Mutation_p.S49Y	NM_006838.3	NP_006829.1	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2	49					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|large_intestine(2)|lung(7)|prostate(1)	13					L-Methionine(DB00134)	AAAGGGCCTTCTGCAGGTAAA	0.577													31	61					2.85442e-18	3.86477e-18	1	1	0	A	95868101	C	A	95868101	3	1	48	1	0	0	0	0	1	0	0	0	9536	913	32	2	148	2	METAP2	12	95868101	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	336798	95868101	37983794	2962	7356										
NTN4	59277	broad.mit.edu	37	chr12	96052892	96052892	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctttttaaaatatccatGacttttcttccaagagaagg	5	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:96052892G>T	ENST00000343702.4	-	10	2305	c.1857C>A	c.(1855-1857)gtC>gtA	p.V619V	PGAM1P5_ENST00000552554.1_RNA|NTN4_ENST00000344911.4_Silent_p.V582V|NTN4_ENST00000538383.1_Silent_p.V582V|NTN4_ENST00000553059.1_Silent_p.V596V	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	619	NTR.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						AAATATCCATGACTTTTCTTC	0.368													16	39					6.31663e-08	7.35827e-08	1	1	0	T	96052892	G	T	96052892	2	4	48	1	0	0	0	0	0	0	0	1	10749	1277	45	2		2	NTN4	12	96052892	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	184791	96052892	37799003	2963	7357										
TMPO	7112	broad.mit.edu	37	chr12	98941517	98941517	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctccattcccgtatggataAaaattttgctgtttgttgtt	8	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:98941517A>C	ENST00000556029.1	+	9	1602	c.1246A>C	c.(1246-1248)Aaa>Caa	p.K416Q	TMPO_ENST00000393053.2_Missense_Mutation_p.K307Q|TMPO_ENST00000343315.5_Missense_Mutation_p.K376Q|TMPO_ENST00000548223.1_3'UTR	NM_001032283.2	NP_001027454.1	P42167	LAP2B_HUMAN	thymopoietin	416						integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CGTATGGATAAAAATTTTGCT	0.368													29	47					0	0	1	0	0	C	98941517	A	C	98941517	3	2	48	1	0	0	0	0	1	0	0	0	16296	15	1	4	2804	4	TMPO	12	98941517	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2888625	98941517	34910378	2964	7358										
ANKS1B	56899	broad.mit.edu	37	chr12	100169404	100169404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttcctgtacaggctcttCgaggactgtagatcttccca	8	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100169404C>T	ENST00000547776.2	-	7	882	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	ANKS1B_ENST00000329257.7_Missense_Mutation_p.E295K|ANKS1B_ENST00000547010.1_Intron	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	295						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ACAGGCTCTTCGAGGACTGTA	0.348													12	11					0	0	1	0	0	T	100169404	C	T	100169404	3	4	48	1	0	0	0	0	1	0	0	0	683	893	31	1	3231	1	ANKS1B	12	100169404	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1227887	100169404	33682491	2965	7359										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100441926	100441926	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccactttcaaatctcagaGaaatctcaggagaggatttg	9	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100441926G>T	ENST00000279907.7	-	18	3979	c.3767C>A	c.(3766-3768)tCt>tAt	p.S1256Y	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.S906Y	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1256										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						AAATCTCAGAGAAATCTCAGG	0.358													14	39					6.49762e-13	8.24929e-13	1	1	0	T	100441926	G	T	100441926	3	4	48	1	0	0	0	0	1	0	0	0	17028	942	33	2	643	2	UHRF1BP1L	12	100441926	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	272522	100441926	33409969	2966	7360										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100453042	100453042	+	Missense_Mutation	SNP	A	A	C													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagtaatatttcctttataAatttcatgcattttggtatc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100453042A>C	ENST00000279907.7	-	14	2225	c.2013T>G	c.(2011-2013)atT>atG	p.I671M	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.I321M	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	671										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TTCCTTTATAAATTTCATGCA	0.338													25	39					0	0	1	0	0	C	100453042	A	C	100453042	3	2	48	1	0	0	0	0	1	0	0	0	17028	10	1	4	2413	4	UHRF1BP1L	12	100453042	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	11116	100453042	33398853	2967	7361	23	2								
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100453047	100453047	+	Nonsense_Mutation	SNP	C	C	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatatttcctttataaatttCatgcattttggtatcttgtt							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100453047C>A	ENST00000279907.7	-	14	2220	c.2008G>T	c.(2008-2010)Gaa>Taa	p.E670*	UHRF1BP1L_ENST00000545232.2_Nonsense_Mutation_p.E320*	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	670										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TTATAAATTTCATGCATTTTG	0.338													25	44					1.1804e-14	1.54286e-14	1	1	0	A	100453047	C	A	100453047	4	1	48	1	0	0	0	0	0	1	0	0	17028	835	29	2	2418	2	UHRF1BP1L	12	100453047	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5	100453047	33398848	2968	7362	23	2								
GOLGA2B	0	broad.mit.edu	37	chr12	100551073	100551073	+	RNA	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagacgctggggcccctctgAccaatgtgcagctctctttg	11	14	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100551073A>G	ENST00000397112.4	-	0	1893				AC010203.1_ENST00000408843.1_RNA	NR_036632.1															large_intestine(1)|lung(3)	4						GGCCCCTCTGACCAATGTGCA	0.592													42	74					0	0	1	0	0	G	100551073	A	G	100551073	1	3	48	0	1	0	0	0	0	0	0	0	6594	290	10	4		4	GOLGA2B	12	100551073	RNA	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	98026	100551073	33300822	2969	7363										
SCYL2	55681	broad.mit.edu	37	chr12	100727960	100727960	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagttcaattctttcatttCcgtcataaaagaaatgctta	4	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100727960C>T	ENST00000360820.2	+	14	2215	c.1778C>T	c.(1777-1779)tCc>tTc	p.S593F		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	593					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						TCTTTCATTTCCGTCATAAAA	0.308													21	34					0	0	1	0	0	T	100727960	C	T	100727960	3	4	48	1	0	0	0	0	1	0	0	0	14001	855	30	3	1828	3	SCYL2	12	100727960	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	176887	100727960	33123935	2970	7364										
NR1H4	9971	broad.mit.edu	37	chr12	100928670	100928670	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgcttatttgttttaggcTtgttaactgaaattcagtgt	8	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100928670T>G	ENST00000548884.1	+	6	1130	c.589T>G	c.(589-591)Ttg>Gtg	p.L197V	NR1H4_ENST00000188403.7_Missense_Mutation_p.L207V|NR1H4_ENST00000392986.3_Missense_Mutation_p.L201V|NR1H4_ENST00000551379.1_Missense_Mutation_p.L211V|NR1H4_ENST00000549996.1_Missense_Mutation_p.L150V	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	211					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TGTTTTAGGCTTGTTAACTGA	0.428													18	41					0	0	1	0	0	G	100928670	T	G	100928670	3	3	48	1	0	0	0	0	1	0	0	0	10666	1606	56	4	603	4	NR1H4	12	100928670	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	200710	100928670	32923225	2971	7365										
NR1H4	9971	broad.mit.edu	37	chr12	100934521	100934521	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggttgaagctatgttccttCgttcagctgagattttcaat	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:100934521C>T	ENST00000548884.1	+	9	1532	c.991C>T	c.(991-993)Cgt>Tgt	p.R331C	NR1H4_ENST00000188403.7_Missense_Mutation_p.R341C|NR1H4_ENST00000392986.3_Missense_Mutation_p.R335C|NR1H4_ENST00000551379.1_Missense_Mutation_p.R345C|NR1H4_ENST00000549996.1_Missense_Mutation_p.R284C	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	345	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TATGTTCCTTCGTTCAGCTGA	0.388													36	49					0	0	1	0	0	T	100934521	C	T	100934521	3	4	48	1	0	0	0	0	1	0	0	0	10666	884	31	1	1017	1	NR1H4	12	100934521	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5851	100934521	32917374	2972	7366										
ANO4	121601	broad.mit.edu	37	chr12	101413875	101413875	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagtagaatcgtgcatcaCattttacaaagaataaaata	6	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:101413875C>A	ENST00000392979.3	+	8	1054	c.693C>A	c.(691-693)caC>caA	p.H231Q	ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392977.3_Missense_Mutation_p.H266Q|ANO4_ENST00000538618.1_3'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	266						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCGTGCATCACATTTTACAAA	0.299										HNSCC(74;0.22)			13	24					2.32078e-09	2.7896e-09	1	1	0	A	101413875	C	A	101413875	3	1	48	1	0	0	0	0	1	0	0	0	693	477	17	5	719	5	ANO4	12	101413875	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	479354	101413875	32438020	2973	7367										
UTP20	27340	broad.mit.edu	37	chr12	101679554	101679554	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacaaagaagttattgacaAatgccaatcattcaatcagt	5	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:101679554A>C	ENST00000261637.4	+	4	395	c.221A>C	c.(220-222)aAa>aCa	p.K74T		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	74					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GTTATTGACAAATGCCAATCA	0.358													19	46					0	0	1	0	0	C	101679554	A	C	101679554	3	2	48	1	0	0	0	0	1	0	0	0	17158	14	1	4	235	4	UTP20	12	101679554	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	265679	101679554	32172341	2974	7368										
UTP20	27340	broad.mit.edu	37	chr12	101693498	101693498	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagactagatccaagggaaGaaacgaacagtttccagtat	10	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:101693498G>T	ENST00000261637.4	+	13	1643	c.1469G>T	c.(1468-1470)aGa>aTa	p.R490I		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	490					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TCCAAGGGAAGAAACGAACAG	0.358													12	40					1.08611e-07	1.25818e-07	1	1	0	T	101693498	G	T	101693498	3	4	48	1	0	0	0	0	1	0	0	0	17158	942	33	2	1519	2	UTP20	12	101693498	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13944	101693498	32158397	2975	7369										
UTP20	27340	broad.mit.edu	37	chr12	101759345	101759345	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatgacagctgaatccattCtattactcagttatggtttg	7	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:101759345C>A	ENST00000261637.4	+	46	6241	c.6067C>A	c.(6067-6069)Cta>Ata	p.L2023I		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2023					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TGAATCCATTCTATTACTCAG	0.373													3	12					0.004672	0.00483628	1	1	0	A	101759345	C	A	101759345	3	1	48	1	0	0	0	0	1	0	0	0	17158	912	32	2	6249	2	UTP20	12	101759345	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	65847	101759345	32092550	2976	7370										
SPIC	121599	broad.mit.edu	37	chr12	101873373	101873373	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattagattacagaaattaCctggctttaatcaaccatcg	5	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:101873373C>A	ENST00000551346.1	+	4	270	c.111C>A	c.(109-111)taC>taA	p.Y37*	SPIC_ENST00000299272.5_Nonsense_Mutation_p.Y37*			Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	37						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	22						ACAGAAATTACCTGGCTTTAA	0.338													16	26					1.67942e-08	1.98515e-08	1	1	0	A	101873373	C	A	101873373	4	1	48	1	0	0	0	0	0	1	0	0	15106	518	18	5	115	5	SPIC	12	101873373	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	114028	101873373	31978522	2977	7371										
MYBPC1	4604	broad.mit.edu	37	chr12	102038555	102038555	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggtataaaaatggtcaaGaaattcgacccagtaccaag	8	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:102038555G>T	ENST00000549145.1	+	11	1010	c.910G>T	c.(910-912)Gaa>Taa	p.E304*	MYBPC1_ENST00000547405.1_Nonsense_Mutation_p.E265*|MYBPC1_ENST00000551300.1_Nonsense_Mutation_p.E192*|MYBPC1_ENST00000452455.2_Nonsense_Mutation_p.E291*|MYBPC1_ENST00000360610.2_Nonsense_Mutation_p.E291*|MYBPC1_ENST00000392934.3_Nonsense_Mutation_p.E278*|MYBPC1_ENST00000441232.1_Nonsense_Mutation_p.E291*|MYBPC1_ENST00000361466.2_Nonsense_Mutation_p.E316*|MYBPC1_ENST00000536007.1_Nonsense_Mutation_p.E272*|MYBPC1_ENST00000541119.1_Nonsense_Mutation_p.E279*|MYBPC1_ENST00000547509.1_Nonsense_Mutation_p.E277*|MYBPC1_ENST00000545503.2_Nonsense_Mutation_p.E291*|MYBPC1_ENST00000553190.1_Nonsense_Mutation_p.E291*|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000550270.1_Nonsense_Mutation_p.E291*|MYBPC1_ENST00000361685.2_Nonsense_Mutation_p.E316*			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	291	Ig-like C2-type 2.			HKGCQRILFIN -> DTRCQSILNID (in Ref. 1; CAA46987).	cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AAATGGTCAAGAAATTCGACC	0.398													8	13					0.00448238	0.00465112	1	1	0	T	102038555	G	T	102038555	4	4	48	1	0	0	0	0	0	1	0	0	10058	943	33	2	992	2	MYBPC1	12	102038555	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	165182	102038555	31813340	2978	7372										
MYBPC1	4604	broad.mit.edu	37	chr12	102067366	102067366	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagtcaaagtggacaaattCgtggagaccgcatcaattga	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:102067366C>T	ENST00000549145.1	+	25	2893	c.2793C>T	c.(2791-2793)ttC>ttT	p.F931F	MYBPC1_ENST00000547405.1_Silent_p.F874F|MYBPC1_ENST00000551300.1_Silent_p.F801F|MYBPC1_ENST00000452455.2_Silent_p.F918F|MYBPC1_ENST00000360610.2_Silent_p.F918F|MYBPC1_ENST00000392934.3_Silent_p.F887F|MYBPC1_ENST00000441232.1_Silent_p.F918F|MYBPC1_ENST00000361466.2_Silent_p.F925F|MYBPC1_ENST00000536007.1_Silent_p.F881F|MYBPC1_ENST00000541119.1_Silent_p.F888F|MYBPC1_ENST00000547509.1_Silent_p.F886F|MYBPC1_ENST00000545503.2_Silent_p.F900F|MYBPC1_ENST00000553190.1_Silent_p.F900F|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000550270.1_Silent_p.F918F|MYBPC1_ENST00000361685.2_Silent_p.F925F			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	918	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding	p.F925L(1)|p.F918L(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						TGGACAAATTCGTGGAGACCG	0.418													57	114					0	0	1	0	0	T	102067366	C	T	102067366	2	4	48	1	0	0	0	0	0	0	0	1	10058	883	31	1		1	MYBPC1	12	102067366	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	28811	102067366	31784529	2979	7373										
SYCP3	50511	broad.mit.edu	37	chr12	102122937	102122937	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccatttcttttttaaattCattttgtgcaccagtaagta	5	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:102122937C>A	ENST00000392927.3	-	8	738	c.607G>T	c.(607-609)Gaa>Taa	p.E203*	SYCP3_ENST00000266743.2_Nonsense_Mutation_p.E203*|SYCP3_ENST00000392924.1_Nonsense_Mutation_p.E203*	NM_001177948.1|NM_001177949.1|NM_153694.4	NP_001171419.1|NP_001171420.1|NP_710161.1	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	203	Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding	p.E203K(1)		endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						TTTTTAAATTCATTTTGTGCA	0.279													6	17					0.00116845	0.00122532	1	1	0	A	102122937	C	A	102122937	4	1	48	1	0	0	0	0	0	1	0	0	15490	835	29	2	111	2	SYCP3	12	102122937	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	55571	102122937	31728958	2980	7374										
GNPTAB	79158	broad.mit.edu	37	chr12	102153891	102153891	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaagcatttttgagcaatTtattagcatgtgttccagac	9	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:102153891T>G	ENST00000299314.7	-	16	3428	c.3166A>C	c.(3166-3168)Aat>Cat	p.N1056H		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	1056					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						TTTGAGCAATTTATTAGCATG	0.353													20	49					0	0	1	0	0	G	102153891	T	G	102153891	3	3	48	1	0	0	0	0	1	0	0	0	6586	1841	64	4	628	4	GNPTAB	12	102153891	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	30954	102153891	31698004	2981	7375										
C12orf42	374470	broad.mit.edu	37	chr12	103700009	103700009	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggagaggaacggaattctTcatagctttcttcatcaaaa	8	8	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:103700009T>G	ENST00000548048.1	-	8	669	c.173A>C	c.(172-174)gAa>gCa	p.E58A	C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000548883.1_Missense_Mutation_p.E125A|C12orf42_ENST00000548789.1_5'UTR|C12orf42_ENST00000378113.2_Missense_Mutation_p.E125A			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	125										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						ACGGAATTCTTCATAGCTTTC	0.453													5	29					0	0	1	0	0	G	103700009	T	G	103700009	3	3	48	1	0	0	0	0	1	0	0	0	1694	1783	62	4	716	4	C12orf42	12	103700009	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1546118	103700009	30151886	2982	7376										
STAB2	55576	broad.mit.edu	37	chr12	104122665	104122665	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacggtttaatgccccaggtTcttcggtaccatgtggtcgc	11	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:104122665T>A	ENST00000388887.2	+	48	5178	c.4974T>A	c.(4972-4974)gtT>gtA	p.V1658V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1658	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGCCCCAGGTTCTTCGGTACC	0.488													9	100					0	0	1	0	0	A	104122665	T	A	104122665	2	1	48	1	0	0	0	0	0	0	0	1	15293	1770	62	4		4	STAB2	12	104122665	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	422656	104122665	29729230	2983	7377										
STAB2	55576	broad.mit.edu	37	chr12	104134518	104134518	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtgctgcaagggctacttCgggcgagactgtcagggtga	17	8	1	2	rs151219602		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:104134518C>T	ENST00000388887.2	+	55	6069	c.5865C>T	c.(5863-5865)ttC>ttT	p.F1955F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1955					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGGGCTACTTCGGGCGAGACT	0.547													16	85					0	0	1	0	0	T	104134518	C	T	104134518	2	4	48	1	0	0	0	0	0	0	0	1	15293	883	31	1		1	STAB2	12	104134518	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11853	104134518	29717377	2984	7378										
HSP90B1	7184	broad.mit.edu	37	chr12	104335423	104335423	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagctctatgtgcgccgtgTattcatcacagacgacttcc	8	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:104335423T>C	ENST00000299767.5	+	10	1429	c.1247T>C	c.(1246-1248)gTa>gCa	p.V416A		NM_003299.1	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	416					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	GTGCGCCGTGTATTCATCACA	0.378													24	49					0	0	1	0	0	C	104335423	T	C	104335423	3	2	48	1	0	0	0	0	1	0	0	0	7445	1638	57	4	1285	4	HSP90B1	12	104335423	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	200905	104335423	29516472	2985	7379										
HSP90B1	7184	broad.mit.edu	37	chr12	104336433	104336433	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgtgattgaagaccactcGaatcgaacacgtcttgctaa	10	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:104336433G>A	ENST00000299767.5	+	12	1685	c.1503G>A	c.(1501-1503)tcG>tcA	p.S501S		NM_003299.1	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	501					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	AAGACCACTCGAATCGAACAC	0.393													17	39					0	0	1	0	0	A	104336433	G	A	104336433	2	1	48	1	0	0	0	0	0	0	0	1	7445	1045	37	1		1	HSP90B1	12	104336433	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1010	104336433	29515462	2986	7380										
TDG	6996	broad.mit.edu	37	chr12	104373823	104373823	+	Translation_Start_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accaagactctccccgatatTttgaccttcaatctggacat	5	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:104373823T>A	ENST00000542036.1	+	0	91				TDG_ENST00000266775.9_Silent_p.I123I|TDG_ENST00000544861.1_De_novo_Start_InFrame|TDG_ENST00000392872.3_Silent_p.I127I			Q13569	TDG_HUMAN	thymine-DNA glycosylase						depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TCCCCGATATTTTGACCTTCA	0.358								Base excision repair (BER), DNA glycosylases					19	41					0	0	1	0	0	A	104373823	T	A	104373823	1	1	48	1	0	0	0	0	0	0	0	0	15783	1829	64	4		4	TDG	12	104373823	Translation_Start_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	37390	104373823	29478072	2987	7381										
HCFC2	29915	broad.mit.edu	37	chr12	104492166	104492166	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacagtgaaagcgggagaaCgacaatggtgtgatgtggga	16	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:104492166C>T	ENST00000229330.4	+	13	1890	c.1786C>T	c.(1786-1788)Cga>Tga	p.R596*	HCFC2_ENST00000550335.1_3'UTR	NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	596	Fibronectin type-III 2.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity	p.R596*(1)		breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						AGCGGGAGAACGACAATGGTG	0.358													15	26					0	0	1	0	0	T	104492166	C	T	104492166	4	4	48	1	0	0	0	0	0	1	0	0	7033	528	19	1	1836	1	HCFC2	12	104492166	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	118343	104492166	29359729	2988	7382										
CHST11	50515	broad.mit.edu	37	chr12	105151374	105151374	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtacgagacactggaagaGgattctaattacgtcctgca	10	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:105151374G>T	ENST00000303694.5	+	3	1291	c.852G>T	c.(850-852)gaG>gaT	p.E284D	CHST11_ENST00000549260.1_Missense_Mutation_p.E279D	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	284					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						CACTGGAAGAGGATTCTAATT	0.517													21	28					1.00905e-13	1.29777e-13	1	1	0	T	105151374	G	T	105151374	3	4	48	1	0	0	0	0	1	0	0	0	3421	991	35	5	862	5	CHST11	12	105151374	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	659208	105151374	28700521	2989	7383										
KIAA1033	23325	broad.mit.edu	37	chr12	105527584	105527584	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacgtctttgtgagctcatgGatgatgaaaatggaatctat	10	5	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:105527584G>A	ENST00000332180.5	+	14	1323	c.1236G>A	c.(1234-1236)tgG>tgA	p.W412*		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	412					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TGAGCTCATGGATGATGAAAA	0.333													20	48					0	0	1	0	0	A	105527584	G	A	105527584	4	1	48	1	0	0	0	0	0	1	0	0	8247	1183	41	3	1290	3	KIAA1033	12	105527584	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	376210	105527584	28324311	2990	7384										
KIAA1033	23325	broad.mit.edu	37	chr12	105535003	105535003	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcatgaaaaaactggatcTtattagtgaacttagagaac	8	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:105535003T>G	ENST00000332180.5	+	18	1853	c.1766T>G	c.(1765-1767)cTt>cGt	p.L589R		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	589					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						AAACTGGATCTTATTAGTGAA	0.363													32	61					0	0	1	0	0	G	105535003	T	G	105535003	3	3	48	1	0	0	0	0	1	0	0	0	8247	1609	56	4	1836	4	KIAA1033	12	105535003	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7419	105535003	28316892	2991	7385										
CKAP4	10970	broad.mit.edu	37	chr12	106633909	106633909	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccgctcctccaccgtgttCtccagggacgtgaagtcccg	11	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:106633909C>A	ENST00000378026.4	-	2	838	c.702G>T	c.(700-702)gaG>gaT	p.E234D	CKAP4_ENST00000552828.1_5'UTR	NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	234						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						CCACCGTGTTCTCCAGGGACG	0.552													37	63					9.45814e-24	1.32461e-23	1	1	0	A	106633909	C	A	106633909	3	1	48	1	0	0	0	0	1	0	0	0	3467	912	32	2	1110	2	CKAP4	12	106633909	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1098906	106633909	27217986	2992	7386										
BTBD11	121551	broad.mit.edu	37	chr12	108004065	108004065	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggatgctgaactgtggacGaacagacctggtgaagcagg	15	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108004065G>A	ENST00000280758.5	+	5	2270	c.1742G>A	c.(1741-1743)cGa>cAa	p.R581Q	RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000357167.4_Missense_Mutation_p.R118Q|BTBD11_ENST00000490090.2_Missense_Mutation_p.R581Q|BTBD11_ENST00000420571.2_Missense_Mutation_p.R581Q	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	581						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AACTGTGGACGAACAGACCTG	0.582											OREG0022090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	85					0	0	1	0	0	A	108004065	G	A	108004065	3	1	48	1	0	0	0	0	1	0	0	0	1541	1058	37	1	1865	1	BTBD11	12	108004065	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1370156	108004065	25847830	2993	7387										
BTBD11	121551	broad.mit.edu	37	chr12	108010898	108010898	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctggggccaaggtggaaggCtcagtggagcatggcgagga	20	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108010898C>T	ENST00000280758.5	+	8	2562	c.2034C>T	c.(2032-2034)ggC>ggT	p.G678G	RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000357167.4_Silent_p.G215G|BTBD11_ENST00000490090.2_Silent_p.G678G|BTBD11_ENST00000420571.2_Silent_p.G678G	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	678						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AGGTGGAAGGCTCAGTGGAGC	0.592													33	57					0	0	1	0	0	T	108010898	C	T	108010898	2	4	48	1	0	0	0	0	0	0	0	1	1541	784	28	3		3	BTBD11	12	108010898	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6833	108010898	25840997	2994	7388										
PWP1	11137	broad.mit.edu	37	chr12	108104226	108104226	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccctgatttgccatttatTtatgcctttggaggtcaaaa	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108104226T>G	ENST00000412830.3	+	14	1503	c.1335T>G	c.(1333-1335)atT>atG	p.I445M	PWP1_ENST00000541166.1_Missense_Mutation_p.I383M	NM_007062.1	NP_008993.1	Q13610	PWP1_HUMAN	PWP1 homolog (S. cerevisiae)	445					transcription, DNA-dependent	nucleus				breast(3)|endometrium(4)|kidney(1)|large_intestine(8)|lung(6)|urinary_tract(1)	23						TGCCATTTATTTATGCCTTTG	0.448													5	62					0	0	1	0	0	G	108104226	T	G	108104226	3	3	48	1	0	0	0	0	1	0	0	0	12894	1829	64	4	1389	4	PWP1	12	108104226	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	93328	108104226	25747669	2995	7389										
PRDM4	11108	broad.mit.edu	37	chr12	108145727	108145727	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgggctggtaaccctagaAacgttctccatagtgattgc	10	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108145727A>C	ENST00000228437.5	-	5	1050	c.591T>G	c.(589-591)gtT>gtG	p.V197V	RP11-864J10.4_ENST00000546714.1_RNA	NM_012406.3	NP_036538.3	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	197					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	20						TAACCCTAGAAACGTTCTCCA	0.512													37	51					0	0	1	0	0	C	108145727	A	C	108145727	2	2	48	1	0	0	0	0	0	0	0	1	12510	1	1	4		4	PRDM4	12	108145727	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	41501	108145727	25706168	2996	7390										
WSCD2	9671	broad.mit.edu	37	chr12	108626509	108626509	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgctccgcccttttcagaCaaccgttgcatggacagaag	9	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108626509C>T	ENST00000332082.4	+	8	1799	c.979_splice	c.e8-1	p.D327_splice	WSCD2_ENST00000261400.3_Splice_Site_p.D327_splice|WSCD2_ENST00000549903.1_Splice_Site_p.D327_splice|WSCD2_ENST00000547525.1_Splice_Site_p.D327_splice			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	327						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						ccttttCAGACAACCGTTGCA	0.592													13	18					0	0	1	0	0	T	108626509	C	T	108626509	5	4	48	1	0	0	0	0	0	0	1	0	17466	492	17	3	1003	3	WSCD2	12	108626509	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	480782	108626509	25225386	2997	7391										
CMKLR1	1240	broad.mit.edu	37	chr12	108685654	108685654	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccctctcattcatagaagtCctctcattcattgatgacat	4	12	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108685654C>A	ENST00000312143.7	-	3	1449	c.1086G>T	c.(1084-1086)agG>agT	p.R362S	CMKLR1_ENST00000552995.1_Missense_Mutation_p.R360S|CMKLR1_ENST00000412676.1_Missense_Mutation_p.R362S|CMKLR1_ENST00000550402.1_Missense_Mutation_p.R362S|CMKLR1_ENST00000397688.2_Missense_Mutation_p.R360S	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	362					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						TCATAGAAGTCCTCTCATTCA	0.498													21	60					6.33239e-15	8.29613e-15	1	1	0	A	108685654	C	A	108685654	3	1	48	1	0	0	0	0	1	0	0	0	3602	854	30	2	39	2	CMKLR1	12	108685654	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	59145	108685654	25166241	2998	7392										
CMKLR1	1240	broad.mit.edu	37	chr12	108686288	108686288	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaagccaggcgaacgctgCggtggttctgggaccagaca	15	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108686288C>T	ENST00000312143.7	-	3	815	c.452G>A	c.(451-453)cGc>cAc	p.R151H	CMKLR1_ENST00000552995.1_Missense_Mutation_p.R149H|CMKLR1_ENST00000412676.1_Missense_Mutation_p.R151H|CMKLR1_ENST00000550402.1_Missense_Mutation_p.R151H|CMKLR1_ENST00000397688.2_Missense_Mutation_p.R149H	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	151					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						GCGAACGCTGCGGTGGTTCTG	0.567													4	90					0	0	1	0	0	T	108686288	C	T	108686288	3	4	48	1	0	0	0	0	1	0	0	0	3602	768	27	1	673	1	CMKLR1	12	108686288	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	634	108686288	25165607	2999	7393										
SART3	9733	broad.mit.edu	37	chr12	108931363	108931363	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccggcattcaaagctttctCgaaggttactggagttggag	13	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:108931363C>T	ENST00000228284.3	-	9	1444	c.1210G>A	c.(1210-1212)Gag>Aag	p.E404K	SART3_ENST00000431469.2_Intron	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	404					RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						AAAGCTTTCTCGAAGGTTACT	0.403									Porokeratosis				16	22					0	0	1	0	0	T	108931363	C	T	108931363	3	4	48	1	0	0	0	0	1	0	0	0	13899	893	31	1	1725	1	SART3	12	108931363	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	245075	108931363	24920532	3000	7394										
MYO1H	283446	broad.mit.edu	37	chr12	109863801	109863801	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccttctagaaaccctcatCtctaaggagccctcctacat	5	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:109863801C>A	ENST00000310903.5	+	18	1834	c.1728C>A	c.(1726-1728)atC>atA	p.I576I	MYO1H_ENST00000431443.2_Silent_p.I586I			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AAACCCTCATCTCTAAGGAGC	0.502													18	31					6.94344e-10	8.4399e-10	1	1	0	A	109863801	C	A	109863801	2	1	48	1	0	0	0	0	0	0	0	1	10122	903	32	2		2	MYO1H	12	109863801	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	932438	109863801	23988094	3001	7395										
MMAB	326625	broad.mit.edu	37	chr12	109994855	109994855	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtccctcagactcggccGatgggtcatttttcatgtat	10	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:109994855G>A	ENST00000545712.2	-	9	1124	c.731C>T	c.(730-732)tCg>tTg	p.S244L	MMAB_ENST00000540016.1_Missense_Mutation_p.S192L|MMAB_ENST00000266839.5_Missense_Mutation_p.S153L	NM_052845.3	NP_443077.1	Q96EY8	MMAB_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblB type	244					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGACTCGGCCGATGGGTCATT	0.532													19	24					0	0	1	0	0	A	109994855	G	A	109994855	3	1	48	1	0	0	0	0	1	0	0	0	9687	1059	37	1	25	1	MMAB	12	109994855	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	131054	109994855	23857040	3002	7396										
ANKRD13A	88455	broad.mit.edu	37	chr12	110451051	110451051	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagctgctccaaaaaattctCgaggtatccatgaaaatgtg	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:110451051C>T	ENST00000261739.4	+	3	517	c.351C>T	c.(349-351)ctC>ctT	p.L117L	ANKRD13A_ENST00000550404.1_3'UTR	NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	117										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						AAAAAATTCTCGAGGTATCCA	0.468													16	33					0	0	1	0	0	T	110451051	C	T	110451051	2	4	48	1	0	0	0	0	0	0	0	1	637	871	31	1		1	ANKRD13A	12	110451051	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	456196	110451051	23400844	3003	7397										
IFT81	28981	broad.mit.edu	37	chr12	110618313	110618313	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgaacttaaagctgaattCggtcttttgcagaggactga	11	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:110618313C>T	ENST00000242591.5	+	12	1781	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F	IFT81_ENST00000552912.1_Silent_p.F425F	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	425					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						AAGCTGAATTCGGTCTTTTGC	0.323													5	16					0	0	1	0	0	T	110618313	C	T	110618313	2	4	48	1	0	0	0	0	0	0	0	1	7608	883	31	1		1	IFT81	12	110618313	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	167262	110618313	23233582	3004	7398										
GPN3	51184	broad.mit.edu	37	chr12	110902914	110902914	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttgctcaggacttaccagCcatcacggagtagttgaagt	10	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:110902914C>A	ENST00000543199.1	-	2	355	c.271G>T	c.(271-273)Gct>Tct	p.A91S	GPN3_ENST00000552180.1_5'UTR|GPN3_ENST00000537466.2_Missense_Mutation_p.A62S|GPN3_ENST00000228827.3_Missense_Mutation_p.A52S	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	52						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						GACTTACCAGCCATCACGGAG	0.522													15	31					4.7546e-09	5.67505e-09	1	1	0	A	110902914	C	A	110902914	3	1	48	1	0	0	0	0	1	0	0	0	6658	739	26	5	728	5	GPN3	12	110902914	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	284601	110902914	22948981	3005	7399										
CUX2	23316	broad.mit.edu	37	chr12	111776197	111776197	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagcctgaaggggcgggagCcttttgtccgcatgcagctg	16	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:111776197C>T	ENST00000261726.6	+	20	3458	c.3304C>T	c.(3304-3306)Cct>Tct	p.P1102S		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1102						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GGGGCGGGAGCCTTTTGTCCG	0.577													27	54					0	0	1	0	0	T	111776197	C	T	111776197	3	4	48	1	0	0	0	0	1	0	0	0	4088	739	26	3	3382	3	CUX2	12	111776197	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	873283	111776197	22075698	3006	7400										
PTPN11	5781	broad.mit.edu	37	chr12	112893786	112893786	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcgtataaatgctgctgaAatagaaagcagagttcgaga	10	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:112893786A>C	ENST00000351677.2	+	6	873	c.675A>C	c.(673-675)gaA>gaC	p.E225D	PTPN11_ENST00000392597.1_Missense_Mutation_p.E225D	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	225					axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						ATGCTGCTGAAATAGAAAGCA	0.348			Mis		"JMML, AML, MDS"		Noonan Syndrome		Noonan syndrome				19	26					0	0	1	0	0	C	112893786	A	C	112893786	3	2	48	1	0	0	0	0	1	0	0	0	12829	11	1	4	697	4	PTPN11	12	112893786	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1117589	112893786	20958109	3007	7401										
OAS2	0	broad.mit.edu	37	chr12	113436156	113436156	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctgaaaaaagaagctcaaAcctggttgacttctcccaac	8	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:113436156A>G	ENST00000392583.2	+	5	1156	c.949A>G	c.(949-951)Acc>Gcc	p.T317A	OAS2_ENST00000342315.4_Missense_Mutation_p.T317A|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	317	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						AGAAGCTCAAACCTGGTTGAC	0.433													32	74					0	0	1	0	0	G	113436156	A	G	113436156	3	3	48	1	0	0	0	0	1	0	0	0	10847	43	2	4	1038	4	OAS2	12	113436156	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	542370	113436156	20415739	3008	7402										
DDX54	79039	broad.mit.edu	37	chr12	113599158	113599158	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtccgagtcacgatcatcaAttttctgtttctgtttccac	6	12	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:113599158A>C	ENST00000314045.7	-	19	2357	c.2330T>G	c.(2329-2331)aTt>aGt	p.I777S	DDX54_ENST00000306014.5_Missense_Mutation_p.I777S|DDX54_ENST00000549271.1_5'UTR	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	777					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						ACGATCATCAATTTTCTGTTT	0.587													24	27					0	0	1	0	0	C	113599158	A	C	113599158	3	2	48	1	0	0	0	0	1	0	0	0	4395	101	4	4	326	4	DDX54	12	113599158	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	163002	113599158	20252737	3009	7403										
RBM19	9904	broad.mit.edu	37	chr12	114364909	114364909	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgagattcttaataaacaGagtacatcctgggaggctct	9	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:114364909G>A	ENST00000545145.2	-	17	2272	c.2194C>T	c.(2194-2196)Ctg>Ttg	p.L732L	RBM19_ENST00000392561.3_Silent_p.L732L|RBM19_ENST00000261741.5_Silent_p.L732L	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	732	RRM 5.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TTAATAAACAGAGTACATCCT	0.483													15	26					0	0	1	0	0	A	114364909	G	A	114364909	2	1	48	1	0	0	0	0	0	0	0	1	13172	933	33	3		3	RBM19	12	114364909	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	765751	114364909	19486986	3010	7404										
TBX5	6910	broad.mit.edu	37	chr12	114803995	114803995	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcttggtacaatggtaaatTtggctatgctcctggggcag	12	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:114803995T>G	ENST00000310346.4	-	8	1623	c.957A>C	c.(955-957)caA>caC	p.Q319H	TBX5_ENST00000349716.5_Missense_Mutation_p.Q269H|TBX5_ENST00000526441.1_Missense_Mutation_p.Q319H|TBX5_ENST00000405440.2_Missense_Mutation_p.Q319H	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	319					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AATGGTAAATTTGGCTATGCT	0.532													7	65					0	0	1	0	0	G	114803995	T	G	114803995	3	3	48	1	0	0	0	0	1	0	0	0	15720	1838	64	4	674	4	TBX5	12	114803995	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	439086	114803995	19047900	3011	7405										
TBX5	6910	broad.mit.edu	37	chr12	114832641	114832641	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagccaaatccattattttCatccgctttcacgatgtgta	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:114832641C>A	ENST00000310346.4	-	6	1234	c.568G>T	c.(568-570)Gaa>Taa	p.E190*	TBX5_ENST00000349716.5_Nonsense_Mutation_p.E140*|TBX5_ENST00000526441.1_Nonsense_Mutation_p.E190*|TBX5_ENST00000405440.2_Nonsense_Mutation_p.E190*	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	190					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CCATTATTTTCATCCGCTTTC	0.358													76	135					1.75807e-36	2.52894e-36	1	1	0	A	114832641	C	A	114832641	4	1	48	1	0	0	0	0	0	1	0	0	15720	835	29	2	1071	2	TBX5	12	114832641	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	28646	114832641	19019254	3012	7406										
MED13L	23389	broad.mit.edu	37	chr12	116408498	116408498	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgtgtgtacaagaagcatCttgaggggtgttgagctgag	16	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:116408498C>A	ENST00000281928.3	-	27	6174	c.5968G>T	c.(5968-5970)Gat>Tat	p.D1990Y		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1990					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CAAGAAGCATCTTGAGGGGTG	0.453													27	37					1.03073e-24	1.44895e-24	1	1	0	A	116408498	C	A	116408498	3	1	48	1	0	0	0	0	1	0	0	0	9480	913	32	2	684	2	MED13L	12	116408498	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1575857	116408498	17443397	3013	7407										
MED13L	23389	broad.mit.edu	37	chr12	116446641	116446641	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggcacggccatttgcttaTcatatttcctactgctagac	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:116446641T>G	ENST00000281928.3	-	10	1783	c.1577A>C	c.(1576-1578)gAt>gCt	p.D526A		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	526					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CATTTGCTTATCATATTTCCT	0.468													21	25					0	0	1	0	0	G	116446641	T	G	116446641	3	3	48	1	0	0	0	0	1	0	0	0	9480	1435	50	4	5143	4	MED13L	12	116446641	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	38143	116446641	17405254	3014	7408										
MED13L	23389	broad.mit.edu	37	chr12	116534522	116534522	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtagggtcggacaaaccatTtcccaatcctaacgaagttc	8	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:116534522T>C	ENST00000281928.3	-	4	637	c.431A>G	c.(430-432)aAa>aGa	p.K144R		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	144					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GACAAACCATTTCCCAATCCT	0.388													19	18					0	0	1	0	0	C	116534522	T	C	116534522	3	2	48	1	0	0	0	0	1	0	0	0	9480	1841	64	4	6313	4	MED13L	12	116534522	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	87881	116534522	17317373	3015	7409										
RFC5	5985	broad.mit.edu	37	chr12	118467596	118467596	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgactttccatcttcagttCgaatacatttattgaccaaa	4	9	2	2	rs141299152		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:118467596C>T	ENST00000392542.2	+	11	1362	c.829C>T	c.(829-831)Cga>Tga	p.R277*	RFC5_ENST00000229043.3_Nonsense_Mutation_p.R213*|RFC5_ENST00000543153.1_3'UTR|RFC5_ENST00000454402.2_Nonsense_Mutation_p.R298*	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	298					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATCTTCAGTTCGAATACATTT	0.363													35	55					0	0	1	0	0	T	118467596	C	T	118467596	4	4	48	1	0	0	0	0	0	1	0	0	13299	876	31	1	936	1	RFC5	12	118467596	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1933074	118467596	15384299	3016	7410										
WSB2	55884	broad.mit.edu	37	chr12	118474182	118474182	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgccggtgtaggggtcccacAtaatcacattggtatcgtaa	11	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:118474182A>C	ENST00000315436.3	-	6	935	c.794T>G	c.(793-795)aTg>aGg	p.M265R	WSB2_ENST00000544233.1_Missense_Mutation_p.M55R|WSB2_ENST00000536738.1_5'UTR|WSB2_ENST00000542304.1_Missense_Mutation_p.M40R|WSB2_ENST00000441406.2_Missense_Mutation_p.M282R|WSB2_ENST00000535496.1_Missense_Mutation_p.M267R	NM_001278557.1|NM_018639.3	NP_001265486.1|NP_061109.1	Q9NYS7	WSB2_HUMAN	WD repeat and SOCS box containing 2	265					intracellular signal transduction					breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGGTCCCACATAATCACATT	0.532													54	114					0	0	1	0	0	C	118474182	A	C	118474182	3	2	48	1	0	0	0	0	1	0	0	0	17464	217	8	4	436	4	WSB2	12	118474182	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6586	118474182	15377713	3017	7411										
TAOK3	51347	broad.mit.edu	37	chr12	118675943	118675943	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctccatgagtaatggcagcGatctccacttcctgaagtgg	11	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:118675943G>A	ENST00000392533.3	-	7	862	c.372C>T	c.(370-372)atC>atT	p.I124I	TAOK3_ENST00000419821.2_Silent_p.I124I	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	124	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAATGGCAGCGATCTCCACTT	0.363													23	55					0	0	1	0	0	A	118675943	G	A	118675943	2	1	48	1	0	0	0	0	0	0	0	1	15605	1048	37	1		1	TAOK3	12	118675943	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	201761	118675943	15175952	3018	7412										
SRRM4	84530	broad.mit.edu	37	chr12	119583269	119583269	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaggacgttcccaggagtaCgactcaggaaatgacacgtc	12	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:119583269C>T	ENST00000267260.4	+	9	1243	c.855C>T	c.(853-855)taC>taT	p.Y285Y		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	285	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CCCAGGAGTACGACTCAGGAA	0.607													10	9					0	0	1	0	0	T	119583269	C	T	119583269	2	4	48	1	0	0	0	0	0	0	0	1	15226	547	19	1		1	SRRM4	12	119583269	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	907326	119583269	14268626	3019	7413										
SRRM4	84530	broad.mit.edu	37	chr12	119588844	119588844	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttcagtcaccgtgtctgGaatgtgccgaagtgaagaag	13	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:119588844G>A	ENST00000267260.4	+	10	1487	c.1099G>A	c.(1099-1101)Gaa>Aaa	p.E367K		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	367	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						ACCGTGTCTGGAATGTGCCGA	0.557													12	20					0	0	1	0	0	A	119588844	G	A	119588844	3	1	48	1	0	0	0	0	1	0	0	0	15226	1175	41	3	1137	3	SRRM4	12	119588844	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5575	119588844	14263051	3020	7414										
CIT	11113	broad.mit.edu	37	chr12	120195211	120195211	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagttccagcagccgattCttgtcactgtggtcttggtg	11	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:120195211C>A	ENST00000392521.2	-	22	2725	c.2670G>T	c.(2668-2670)aaG>aaT	p.K890N	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.K848N	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	848					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GCAGCCGATTCTTGTCACTGT	0.547													6	374					0.0215528	0.0219788	1	1	0	A	120195211	C	A	120195211	3	1	48	1	0	0	0	0	1	0	0	0	3461	912	32	2	3647	2	CIT	12	120195211	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	606367	120195211	13656684	3021	7415										
CIT	11113	broad.mit.edu	37	chr12	120295449	120295449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctacaagacttctgacttCgaagtcctttgccgaaggct	8	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:120295449C>T	ENST00000392521.2	-	4	347	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	CIT_ENST00000261833.7_Missense_Mutation_p.E98K	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	98	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTTCTGACTTCGAAGTCCTTT	0.458													47	107					0	0	1	0	0	T	120295449	C	T	120295449	3	4	48	1	0	0	0	0	1	0	0	0	3461	893	31	1	5967	1	CIT	12	120295449	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	100238	120295449	13556446	3022	7416										
PLA2G1B	5319	broad.mit.edu	37	chr12	120762808	120762808	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgggttgtccagcagaaatTtacagctgtccagcttcttg	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:120762808T>G	ENST00000308366.4	-	3	286	c.251A>C	c.(250-252)aAa>aCa	p.K84T	PLA2G1B_ENST00000423423.3_Intron|PLA2G1B_ENST00000549767.1_Missense_Mutation_p.K55T	NM_000928.2	NP_000919.1	P04054	PA21B_HUMAN	phospholipase A2, group IB (pancreas)	84					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of DNA replication|positive regulation of immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			endometrium(1)|large_intestine(1)|lung(3)|skin(2)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCAGAAATTTACAGCTGTC	0.512											OREG0022189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	58					0	0	1	0	0	G	120762808	T	G	120762808	3	3	48	1	0	0	0	0	1	0	0	0	12041	1841	64	4	203	4	PLA2G1B	12	120762808	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	467359	120762808	13089087	3023	7417										
UNC119B	84747	broad.mit.edu	37	chr12	121151136	121151136	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttcacccgcttcaaaattCgagatttggagacagggaca	9	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:121151136C>T	ENST00000344651.4	+	2	344	c.304C>T	c.(304-306)Cga>Tga	p.R102*	UNC119B_ENST00000539658.1_3'UTR	NM_001080533.1	NP_001074002.1	A6NIH7	U119B_HUMAN	unc-119 homolog B (C. elegans)	102										breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CTTCAAAATTCGAGATTTGGA	0.403													15	42					0	0	1	0	0	T	121151136	C	T	121151136	4	4	48	1	0	0	0	0	0	1	0	0	17042	876	31	1	310	1	UNC119B	12	121151136	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	388328	121151136	12700759	3024	7418										
WDR66	144406	broad.mit.edu	37	chr12	122361794	122361794	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacaagaaaggagagtatcCgacatccagtccaaagcagg	12	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:122361794C>T	ENST00000288912.4	+	3	1499	c.645C>T	c.(643-645)tcC>tcT	p.S215S	WDR66_ENST00000397454.2_Silent_p.S215S	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	215							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GGAGAGTATCCGACATCCAGT	0.517													47	61					0	0	1	0	0	T	122361794	C	T	122361794	2	4	48	1	0	0	0	0	0	0	0	1	17376	639	23	1		1	WDR66	12	122361794	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1210658	122361794	11490101	3025	7419										
KNTC1	9735	broad.mit.edu	37	chr12	123067340	123067340	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagcacattaaagctcacgAagttgcacaggcgaaacaca	9	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:123067340A>G	ENST00000333479.7	+	34	3248	c.3071A>G	c.(3070-3072)gAa>gGa	p.E1024G	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1024					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AAAGCTCACGAAGTTGCACAG	0.498													11	17					0	0	1	0	0	G	123067340	A	G	123067340	3	3	48	1	0	0	0	0	1	0	0	0	8470	246	9	4	3201	4	KNTC1	12	123067340	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	705546	123067340	10784555	3026	7420										
KNTC1	9735	broad.mit.edu	37	chr12	123087284	123087284	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagaacttctggaaaattCtctgtatgtgttcattaact	6	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:123087284C>A	ENST00000333479.7	+	46	4999	c.4822C>A	c.(4822-4824)Ctc>Atc	p.L1608I	KNTC1_ENST00000450485.2_Intron|KNTC1_ENST00000537348.1_Missense_Mutation_p.L33I|KNTC1_ENST00000436959.3_5'UTR	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1608					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTGGAAAATTCTCTGTATGTG	0.358													11	28					3.86212e-05	4.21111e-05	1	1	0	A	123087284	C	A	123087284	3	1	48	1	0	0	0	0	1	0	0	0	8470	913	32	2	5000	2	KNTC1	12	123087284	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19944	123087284	10764611	3027	7421										
DDX55	57696	broad.mit.edu	37	chr12	124102387	124102387	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcctgcccatggaagagTcatacatcaatttccttgca	6	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:124102387T>C	ENST00000238146.4	+	11	1182	c.1132T>C	c.(1132-1134)Tca>Cca	p.S378P	DDX55_ENST00000541259.1_Intron|DDX55_ENST00000538744.1_Missense_Mutation_p.S347P	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	378	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		CATGGAAGAGTCATACATCAA	0.532											OREG0022230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	60					0	0	1	0	0	C	124102387	T	C	124102387	3	2	48	1	0	0	0	0	1	0	0	0	4396	1667	58	4	1174	4	DDX55	12	124102387	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1015103	124102387	9749508	3028	7422										
DDX55	57696	broad.mit.edu	37	chr12	124104541	124104541	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaagatgaggacatggaaGaacttcttaatgacacaaga	10	5	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:124104541G>T	ENST00000238146.4	+	14	1707	c.1657G>T	c.(1657-1659)Gaa>Taa	p.E553*	DDX55_ENST00000538744.1_Nonsense_Mutation_p.E522*|DDX55_ENST00000421670.3_Nonsense_Mutation_p.E160*	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	553	Lys-rich.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GGACATGGAAGAACTTCTTAA	0.343													25	40					1.64293e-13	2.10822e-13	1	1	0	T	124104541	G	T	124104541	4	4	48	1	0	0	0	0	0	1	0	0	4396	943	33	2	1711	2	DDX55	12	124104541	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2154	124104541	9747354	3029	7423										
DNAH10	196385	broad.mit.edu	37	chr12	124326058	124326058	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaatagactaattaccaaaGaggctatttttagatactgt	6	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:124326058G>T	ENST00000409039.3	+	29	4997	c.4972G>T	c.(4972-4974)Gag>Tag	p.E1658*		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1658	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AATTACCAAAGAGGCTATTTT	0.418													21	46					1.28384e-07	1.48174e-07	1	1	0	T	124326058	G	T	124326058	4	4	48	1	0	0	0	0	0	1	0	0	4626	943	33	2	5086	2	DNAH10	12	124326058	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	221517	124326058	9525837	3030	7424										
DNAH10	196385	broad.mit.edu	37	chr12	124371784	124371784	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgggattgagaacaaagcGatgatctttctgttcacgga	11	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:124371784G>A	ENST00000409039.3	+	51	8590	c.8565G>A	c.(8563-8565)gcG>gcA	p.A2855A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2855	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAACAAAGCGATGATCTTTC	0.542													8	26					0	0	1	0	0	A	124371784	G	A	124371784	2	1	48	1	0	0	0	0	0	0	0	1	4626	1045	37	1		1	DNAH10	12	124371784	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	45726	124371784	9480111	3031	7425										
NCOR2	9612	broad.mit.edu	37	chr12	124831140	124831140	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagccctccttgagcggccgCggggccaggggcagctcggg	19	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:124831140C>T	ENST00000356219.3	-	32	4505	c.4350G>A	c.(4348-4350)ccG>ccA	p.P1450P	NCOR2_ENST00000429285.2_Silent_p.P1433P|NCOR2_ENST00000397355.1_Silent_p.P1434P|NCOR2_ENST00000404121.2_Silent_p.P1004P|NCOR2_ENST00000404621.1_Silent_p.P1433P|NCOR2_ENST00000405201.1_Silent_p.P1443P	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1451					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGAGCGGCCGCGGGGCCAGGG	0.726													6	9					0	0	1	0	0	T	124831140	C	T	124831140	2	4	48	1	0	0	0	0	0	0	0	1	10282	755	27	1		1	NCOR2	12	124831140	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	459356	124831140	9020755	3032	7426										
TMEM132D	121256	broad.mit.edu	37	chr12	129558971	129558971	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagcatacatcccaatttCtaagtcgctcagccctttgg	6	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:129558971C>A	ENST00000422113.2	-	9	3075	c.2749G>T	c.(2749-2751)Gaa>Taa	p.E917*	TMEM132D_ENST00000389441.4_Nonsense_Mutation_p.E455*	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	917						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATCCCAATTTCTAAGTCGCTC	0.478													41	63					2.2871e-25	3.22072e-25	1	1	0	A	129558971	C	A	129558971	4	1	48	1	0	0	0	0	0	1	0	0	16106	922	32	2	554	2	TMEM132D	12	129558971	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4727831	129558971	4292924	3033	7427										
PIWIL1	9271	broad.mit.edu	37	chr12	130847640	130847640	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaaacactggtgaactacGaagtgccacagtttttggat	10	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:130847640G>A	ENST00000245255.3	+	18	2418	c.2146G>A	c.(2146-2148)Gaa>Aaa	p.E716K		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	716	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GGTGAACTACGAAGTGCCACA	0.443													29	50					0	0	1	0	0	A	130847640	G	A	130847640	3	1	48	1	0	0	0	0	1	0	0	0	12004	1059	37	1	2212	1	PIWIL1	12	130847640	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1288669	130847640	3004255	3034	7428										
GPR133	283383	broad.mit.edu	37	chr12	131456095	131456095	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaggtacaacagctcctgcAtcagcaagccagagcagtgt	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:131456095A>G	ENST00000261654.5	+	4	839	c.280A>G	c.(280-282)Atc>Gtc	p.I94V	GPR133_ENST00000535015.1_Missense_Mutation_p.I126V	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	94					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CAGCTCCTGCATCAGCAAGCC	0.507													12	26					0	0	1	0	0	G	131456095	A	G	131456095	3	3	48	1	0	0	0	0	1	0	0	0	6682	217	8	4	294	4	GPR133	12	131456095	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	608455	131456095	2395800	3035	7429										
EP400	57634	broad.mit.edu	37	chr12	132479477	132479477	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgttgtggaccaccaaacaGaactttctaatttagccaag	8	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:132479477G>T	ENST00000333577.4	+	13	3020	c.2911G>T	c.(2911-2913)Gaa>Taa	p.E971*	EP400_ENST00000330386.6_Nonsense_Mutation_p.E935*|EP400_ENST00000389561.2_Nonsense_Mutation_p.E935*|EP400_ENST00000389562.2_Nonsense_Mutation_p.E934*|EP400_ENST00000332482.4_Nonsense_Mutation_p.E898*			Q96L91	EP400_HUMAN	E1A binding protein p400	971	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCACCAAACAGAACTTTCTAA	0.373													17	73					3.52763e-06	3.92945e-06	1	1	0	T	132479477	G	T	132479477	4	4	48	1	0	0	0	0	0	1	0	0	5177	943	33	2	2842	2	EP400	12	132479477	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1023382	132479477	1372418	3036	7430										
GALNT9	50614	broad.mit.edu	37	chr12	132688051	132688051	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcctgtgggggactcaccGacatggggatgttccaggcc	16	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:132688051G>A	ENST00000328957.8	-	7	1261	c.1263_splice	c.e7+1	p.S421_splice	GALNT9_ENST00000535228.1_Splice_Site_p.S172_splice|GALNT9_ENST00000541995.1_Splice_Site_p.S55_splice|GALNT9_ENST00000397325.2_Splice_Site_p.S55_splice	NM_001122636.1	NP_001116108.1	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)	421					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.S421L(1)|p.S55L(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(5)	9	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		GGGACTCACCGACATGGGGAT	0.682													21	26					0	0	1	0	0	A	132688051	G	A	132688051	5	1	48	1	0	0	0	0	0	0	1	0	6259	1072	37	1	569	1	GALNT9	12	132688051	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	208574	132688051	1163844	3037	7431										
POLE	5426	broad.mit.edu	37	chr12	133253184	133253184	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggtctgtctcagcatcaGgaaacttgaggggcagtttg	13	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:133253184G>C	ENST00000320574.5	-	9	900	c.857C>G	c.(856-858)cCt>cGt	p.P286R	POLE_ENST00000535270.1_Missense_Mutation_p.P259R	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	286					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding	p.P286H(1)		NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTCAGCATCAGGAAACTTGAG	0.493								DNA polymerases (catalytic subunits)					13	29					0	0	1	0	0	C	133253184	G	C	133253184	3	2	48	1	0	0	0	0	1	0	0	0	12243	1000	35	5	6167	5	POLE	12	133253184	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	565133	133253184	598711	3038	7432										
ZNF10	7556	broad.mit.edu	37	chr12	133727724	133727724	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatgctggagaactataaGaacctggtttccttgggtaa	12	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:133727724G>T	ENST00000248211.6	+	3	366	c.144G>T	c.(142-144)aaG>aaT	p.K48N	CTD-2140B24.4_ENST00000540096.2_Missense_Mutation_p.K48N|ZNF10_ENST00000426665.2_Missense_Mutation_p.K48N|ZNF268_ENST00000416488.1_Missense_Mutation_p.K48N|ZNF10_ENST00000540927.1_3'UTR|ZNF10_ENST00000402932.2_Missense_Mutation_p.K48N	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AGAACTATAAGAACCTGGTTT	0.453													17	40					3.32936e-07	3.80431e-07	1	1	0	T	133727724	G	T	133727724	3	4	48	1	0	0	0	0	1	0	0	0	17769	933	33	2	150	2	ZNF10	12	133727724	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	474540	133727724	124171	3039	7433										
ZNF268	10795	broad.mit.edu	37	chr12	133779416	133779416	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtttcacaccagaaaactCattcaggacagaaaccatat	5	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:133779416C>A	ENST00000536435.2	+	6	1474	c.1144C>A	c.(1144-1146)Cat>Aat	p.H382N	ZNF268_ENST00000228289.5_Missense_Mutation_p.H382N|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000542986.2_3'UTR|ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000537565.1_Missense_Mutation_p.H221N	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	382						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CCAGAAAACTCATTCAGGACA	0.388													5	11					0.184627	0.185817	1	1	0	A	133779416	C	A	133779416	3	1	48	1	0	0	0	0	1	0	0	0	17864	826	29	2		2	ZNF268	12	133779416	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	51692	133779416	72479	3040	7434										
ZNF268	10795	broad.mit.edu	37	chr12	133781007	133781007	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattctcagtgcacatcagaGaacacatacaggagagaagc	9	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr12:133781007G>T	ENST00000536435.2	+	6	3065	c.2735G>T	c.(2734-2736)aGa>aTa	p.R912I	ZNF268_ENST00000228289.5_Missense_Mutation_p.R912I|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000542986.2_3'UTR|ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000537565.1_Missense_Mutation_p.R751I	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	912						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GCACATCAGAGAACACATACA	0.418													4	11					0.014758	0.015099	1	1	0	T	133781007	G	T	133781007	3	4	48	1	0	0	0	0	1	0	0	0	17864	942	33	2		2	ZNF268	12	133781007	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1591	133781007	70888	3041	7435										
TUBA3C	7278	broad.mit.edu	37	chr13	19751395	19751395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattcagggccccgtcaaatCgcagggaggccgtgatggag	15	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:19751395C>T	ENST00000400113.3	-	4	832	c.728G>A	c.(727-729)cGa>cAa	p.R243Q		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	243					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity	p.R243Q(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCCGTCAAATCGCAGGGAGGC	0.597													74	125					0	0	1	0	0	T	19751395	C	T	19751395	3	4	48	1	0	0	0	0	1	0	0	0	16807	884	31	1	632	1	TUBA3C	13	19751395	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		19751395	95418483	3042	7436										
TUBA3C	7278	broad.mit.edu	37	chr13	19752459	19752459	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggcctctggcgtaattaTtggccgcatcttccttcccg	9	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:19752459T>G	ENST00000400113.3	-	3	406	c.302A>C	c.(301-303)aAt>aCt	p.N101T		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	101					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GGCGTAATTATTGGCCGCATC	0.527													15	116					0	0	1	0	0	G	19752459	T	G	19752459	3	3	48	1	0	0	0	0	1	0	0	0	16807	1493	52	4	1062	4	TUBA3C	13	19752459	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1064	19752459	95417419	3043	7437										
TUBA3C	7278	broad.mit.edu	37	chr13	19753677	19753677	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgatctggactcctgcctgCcccacgtggatagagataca	10	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:19753677C>T	ENST00000400113.3	-	2	134	c.30G>A	c.(28-30)ggG>ggA	p.G10G		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	10					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity	p.G10G(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CTCCTGCCTGCCCCACGTGGA	0.463													27	51					0	0	1	0	0	T	19753677	C	T	19753677	2	4	48	1	0	0	0	0	0	0	0	1	16807	726	26	3		3	TUBA3C	13	19753677	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1218	19753677	95416201	3044	7438										
GJA3	2700	broad.mit.edu	37	chr13	20717426	20717426	+	Translation_Start_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaaagctccagtcgcccAttgcttcagattcctaacct	6	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:20717426A>G	ENST00000241125.3	-	2	178	c.2T>C	c.(1-3)aTg>aCg	p.M1T		NM_021954.3	NP_068773.2	Q9Y6H8	CXA3_HUMAN	gap junction protein, alpha 3, 46kDa	1					cell-cell signaling|visual perception	connexon complex|integral to membrane				NS(1)|endometrium(1)|kidney(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		CCAGTCGCCCATTGCTTCAGA	0.577													3	21					0	0	1	0	0	G	20717426	A	G	20717426	1	3	48	1	0	0	0	0	0	0	0	0	6443	217	8	4		4	GJA3	13	20717426	Translation_Start_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	963749	20717426	94452452	3045	7439										
SGCG	6445	broad.mit.edu	37	chr13	23853608	23853608	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggttggtacagataaacttCgagtaactggtatgtactaa	10	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:23853608C>T	ENST00000218867.3	+	5	620	c.496C>T	c.(496-498)Cga>Tga	p.R166*	SGCG_ENST00000545013.1_Nonsense_Mutation_p.R166*|SGCG_ENST00000537476.1_Nonsense_Mutation_p.R166*	NM_000231.2	NP_000222.1	Q13326	SGCG_HUMAN	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	166					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		AGATAAACTTCGAGTAACTGG	0.388													12	17					0	0	1	0	0	T	23853608	C	T	23853608	4	4	48	1	0	0	0	0	0	1	0	0	14256	876	31	1	510	1	SGCG	13	23853608	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3136182	23853608	91316270	3046	7440										
SACS	26278	broad.mit.edu	37	chr13	23904369	23904369	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcagaagtgaacctgtcaTttgggatctgaggaaaggga	13	7	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:23904369T>G	ENST00000382298.3	-	10	14234	c.13646A>C	c.(13645-13647)aAt>aCt	p.N4549T	SACS_ENST00000402364.1_Missense_Mutation_p.N3799T|SACS_ENST00000382292.3_Missense_Mutation_p.N4549T	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4549	HEPN.		N -> D (in SACS).		cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAACCTGTCATTTGGGATCTG	0.373													22	49					0	0	1	0	0	G	23904369	T	G	23904369	3	3	48	1	0	0	0	0	1	0	0	0	13855	1493	52	4	97	4	SACS	13	23904369	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	50761	23904369	91265509	3047	7441										
SACS	26278	broad.mit.edu	37	chr13	23907353	23907353	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcattaggaataaacaatttTtcaggaagcataacttcaaa	5	6	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:23907353T>A	ENST00000382298.3	-	10	11250	c.10662A>T	c.(10660-10662)gaA>gaT	p.E3554D	SACS_ENST00000402364.1_Missense_Mutation_p.E2804D|SACS_ENST00000382292.3_Missense_Mutation_p.E3554D	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3554					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TAAACAATTTTTCAGGAAGCA	0.303													8	7					0	0	1	0	0	A	23907353	T	A	23907353	3	1	48	1	0	0	0	0	1	0	0	0	13855	1838	64	4	3081	4	SACS	13	23907353	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2984	23907353	91262525	3048	7442										
SACS	26278	broad.mit.edu	37	chr13	23910423	23910423	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattaaggatgctcttaattCtgctggtcaatttttctttc	6	8	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:23910423C>T	ENST00000382298.3	-	10	8180	c.7592G>A	c.(7591-7593)aGa>aAa	p.R2531K	SACS_ENST00000402364.1_Missense_Mutation_p.R1781K|SACS_ENST00000382292.3_Missense_Mutation_p.R2531K	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2531					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCTCTTAATTCTGCTGGTCAA	0.393													29	49					0	0	1	0	0	T	23910423	C	T	23910423	3	4	48	1	0	0	0	0	1	0	0	0	13855	913	32	3	6151	3	SACS	13	23910423	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3070	23910423	91259455	3049	7443										
SACS	26278	broad.mit.edu	37	chr13	23932558	23932558	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcctgcttcttgctatttCttgaatgccgtgccagtcct	7	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:23932558C>A	ENST00000382298.3	-	7	1108	c.520G>T	c.(520-522)Gaa>Taa	p.E174*	SACS_ENST00000402364.1_5'UTR|SACS_ENST00000382292.3_Nonsense_Mutation_p.E174*	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	174					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTTGCTATTTCTTGAATGCCG	0.438													47	73					2.14642e-42	3.10745e-42	1	1	0	A	23932558	C	A	23932558	4	1	48	1	0	0	0	0	0	1	0	0	13855	922	32	2	13235	2	SACS	13	23932558	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22135	23932558	91237320	3050	7444										
ATP12A	479	broad.mit.edu	37	chr13	25280568	25280568	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccggacatccccccagcaGaagctgatcattgtggaggg	13	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:25280568G>T	ENST00000218548.6	+	15	2487	c.2154G>T	c.(2152-2154)caG>caT	p.Q718H	ATP12A_ENST00000381946.3_Missense_Mutation_p.Q712H	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	712					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding	p.Q712H(1)		breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CCCCCCAGCAGAAGCTGATCA	0.562													14	36					1.49906e-05	1.64923e-05	1	1	0	T	25280568	G	T	25280568	3	4	48	1	0	0	0	0	1	0	0	0	1121	933	33	2	2212	2	ATP12A	13	25280568	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1348010	25280568	89889310	3051	7445										
RNF17	56163	broad.mit.edu	37	chr13	25378555	25378555	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaatagtcctggagatttCtatcttcagttggtaagtat	8	5	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:25378555C>A	ENST00000255324.5	+	15	2131	c.2079C>A	c.(2077-2079)ttC>ttA	p.F693L	RNF17_ENST00000381921.1_Missense_Mutation_p.F693L|RNF17_ENST00000255325.5_Intron	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	693					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTGGAGATTTCTATCTTCAGT	0.274													3	12					0.004672	0.00483628	1	1	0	A	25378555	C	A	25378555	3	1	48	1	0	0	0	0	1	0	0	0	13512	912	32	2	2137	2	RNF17	13	25378555	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	97987	25378555	89791323	3052	7446										
CENPJ	55835	broad.mit.edu	37	chr13	25458144	25458144	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgggaaaatgctttcttCttgtccatcaggaaataagt	8	7	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:25458144C>A	ENST00000381884.4	-	16	3966	c.3781G>T	c.(3781-3783)Gaa>Taa	p.E1261*	CENPJ_ENST00000545981.1_3'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1261					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		ATGCTTTCTTCTTGTCCATCA	0.373													24	53					6.12954e-19	8.32119e-19	1	1	0	A	25458144	C	A	25458144	4	1	48	1	0	0	0	0	0	1	0	0	3256	922	32	2	243	2	CENPJ	13	25458144	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	79589	25458144	89711734	3053	7447										
CENPJ	55835	broad.mit.edu	37	chr13	25480675	25480675	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggacactcagttacattttCtttattattagatgtgactt	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:25480675C>A	ENST00000381884.4	-	7	1686	c.1501G>T	c.(1501-1503)Gaa>Taa	p.E501*	CENPJ_ENST00000545981.1_Nonsense_Mutation_p.E501*	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	501					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GTTACATTTTCTTTATTATTA	0.423													27	54					7.41945e-09	8.8016e-09	1	1	0	A	25480675	C	A	25480675	4	1	48	1	0	0	0	0	0	1	0	0	3256	922	32	2	2559	2	CENPJ	13	25480675	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22531	25480675	89689203	3054	7448										
RASL11A	387496	broad.mit.edu	37	chr13	27847485	27847485	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttcagcatctctgcaaaGaagtgagcaagatgcacggc	11	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:27847485G>T	ENST00000241463.4	+	4	1201	c.583G>T	c.(583-585)Gaa>Taa	p.E195*	RASL11A_ENST00000480803.1_3'UTR	NM_206827.1	NP_996563.1	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	195	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	10		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		TCTCTGCAAAGAAGTGAGCAA	0.517													22	37					2.37509e-13	3.04217e-13	1	1	0	T	27847485	G	T	27847485	4	4	48	1	0	0	0	0	0	1	0	0	13132	943	33	2	597	2	RASL11A	13	27847485	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2366810	27847485	87322393	3055	7449										
FLT3	2322	broad.mit.edu	37	chr13	28602426	28602426	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagagctgtctgctttttCtgtcaaagaaaggagcatta	9	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:28602426C>A	ENST00000380982.4	-	16	2024		c.e16-1		FLT3_ENST00000537084.1_Splice_Site|FLT3_ENST00000241453.7_Splice_Site			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCTGCTTTTTCTGTCAAAGAA	0.388			"Mis, O"		"AML, ALL"								9	15					0.0477658	0.0484551	1	1	0	A	28602426	C	A	28602426	5	1	48	1	0	0	0	0	0	0	1	0	5974	927	32	2	1075	2	FLT3	13	28602426	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	754941	28602426	86567452	3056	7450										
PAN3	255967	broad.mit.edu	37	chr13	28862175	28862175	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaccgttatctgttgaaactCtttagggatcatctttttca	7	8	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:28862175C>A	ENST00000399613.1	+	17	1902	c.1839C>A	c.(1837-1839)ctC>ctA	p.L613L	PAN3_ENST00000380958.3_Silent_p.L813L|PAN3_ENST00000282391.5_Silent_p.L501L			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	813	Interaction with PAN2.|Protein kinase.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TGTTGAAACTCTTTAGGGATC	0.418													11	24					5.50884e-06	6.10489e-06	1	1	0	A	28862175	C	A	28862175	2	1	48	1	0	0	0	0	0	0	0	1	11461	900	32	2		2	PAN3	13	28862175	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	259749	28862175	86307703	3057	7451										
POMP	51371	broad.mit.edu	37	chr13	29246494	29246494	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggttcagcgtcttccatttCtttcaagctcaaatctttca	5	11	7	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:29246494C>A	ENST00000380842.4	+	5	364	c.283C>A	c.(283-285)Ctt>Att	p.L95I	POMP_ENST00000460403.1_3'UTR	NM_015932.5	NP_057016.1	Q9Y244	POMP_HUMAN	proteasome maturation protein	95					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex				endometrium(2)|kidney(1)|large_intestine(1)	4		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)		TCTTCCATTTCTTTCAAGCTC	0.353													25	49					5.45024e-15	7.15042e-15	1	1	0	A	29246494	C	A	29246494	3	1	48	1	0	0	0	0	1	0	0	0	12291	913	32	2	301	2	POMP	13	29246494	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	384319	29246494	85923384	3058	7452										
MTUS2	23281	broad.mit.edu	37	chr13	30071434	30071434	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggacagagcccgccgcttCgaagaggccttgaggaagaa	15	11	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:30071434C>T	ENST00000431530.3	+	11	3727	c.3669C>T	c.(3667-3669)ttC>ttT	p.F1223F	MTUS2_ENST00000380808.2_Silent_p.F192F|MTUS2_ENST00000400542.3_3'UTR|MTUS2_ENST00000542829.1_Silent_p.F102F	NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	1213						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CCCGCCGCTTCGAAGAGGCCT	0.617													6	14					0	0	1	0	0	T	30071434	C	T	30071434	2	4	48	1	0	0	0	0	0	0	0	1	10013	883	31	1		1	MTUS2	13	30071434	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	824940	30071434	85098444	3059	7453										
USPL1	10208	broad.mit.edu	37	chr13	31231670	31231670	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaaaggcacaagaaatttGaagttcctgcttcagagata	9	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:31231670G>T	ENST00000255304.4	+	9	1798	c.1456G>T	c.(1456-1458)Gaa>Taa	p.E486*		NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	486					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		CAAGAAATTTGAAGTTCCTGC	0.373													20	41					0.0438628	0.0445521	1	1	0	T	31231670	G	T	31231670	4	4	48	1	0	0	0	0	0	1	0	0	17151	1291	45	2	1486	2	USPL1	13	31231670	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1160236	31231670	83938208	3060	7454										
HSPH1	10808	broad.mit.edu	37	chr13	31713236	31713236	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaggagtctcaaaaaattTtgatgatccttaacacaaaa	7	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:31713236T>G	ENST00000320027.5	-	15	2333	c.1989A>C	c.(1987-1989)caA>caC	p.Q663H	HSPH1_ENST00000445273.2_Missense_Mutation_p.Q665H|HSPH1_ENST00000380405.4_Missense_Mutation_p.Q619H|HSPH1_ENST00000380406.5_Missense_Mutation_p.Q622H|HSPH1_ENST00000429785.2_Missense_Mutation_p.Q482H	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	663					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TCAAAAAATTTTGATGATCCT	0.363													10	26					0	0	1	0	0	G	31713236	T	G	31713236	3	3	48	1	0	0	0	0	1	0	0	0	7474	1838	64	4	603	4	HSPH1	13	31713236	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	481566	31713236	83456642	3061	7455										
HSPH1	10808	broad.mit.edu	37	chr13	31714336	31714336	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catacctgctcacatataaaTttttcatatggtccacacag	4	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:31714336T>G	ENST00000320027.5	-	14	2309	c.1965A>C	c.(1963-1965)aaA>aaC	p.K655N	HSPH1_ENST00000445273.2_Missense_Mutation_p.K657N|HSPH1_ENST00000380405.4_Missense_Mutation_p.K611N|HSPH1_ENST00000380406.5_Missense_Mutation_p.K614N|HSPH1_ENST00000429785.2_Missense_Mutation_p.K474N	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	655					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CACATATAAATTTTTCATATG	0.328													19	36					0	0	1	0	0	G	31714336	T	G	31714336	3	3	48	1	0	0	0	0	1	0	0	0	7474	1490	52	4	631	4	HSPH1	13	31714336	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1100	31714336	83455542	3062	7456										
FRY	10129	broad.mit.edu	37	chr13	32759225	32759225	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgacaaagaagttgaaattCttaaagatatccgggcacat	8	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:32759225C>A	ENST00000380250.3	+	26	3755	c.3259C>A	c.(3259-3261)Ctt>Att	p.L1087I		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1087					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGTTGAAATTCTTAAAGATAT	0.438													6	96					0.00116845	0.00122532	1	1	0	A	32759225	C	A	32759225	3	1	48	1	0	0	0	0	1	0	0	0	6097	913	32	2	3361	2	FRY	13	32759225	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1044889	32759225	82410653	3063	7457										
BRCA2	675	broad.mit.edu	37	chr13	32911760	32911760	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagtcatataacccctcagAtgttattttccaagcaggat	6	9	2	1	rs80359381		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:32911760A>C	ENST00000544455.1	+	11	3495	c.3268A>C	c.(3268-3270)Atg>Ctg	p.M1090L	BRCA2_ENST00000380152.3_Missense_Mutation_p.M1090L	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1090					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AACCCCTCAGATGTTATTTTC	0.328			"D, Mis, N, F, S"		"breast, ovarian, pancreatic"	"breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			11	54					0	0	1	0	0	C	32911760	A	C	32911760	3	2	48	1	0	0	0	0	1	0	0	0	1501	333	12	4	3306	4	BRCA2	13	32911760	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	152535	32911760	82258118	3064	7458										
BRCA2	675	broad.mit.edu	37	chr13	32971071	32971071	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaatgaagcagaaaacaagCttatgcatatactgcatgca	8	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:32971071C>T	ENST00000544455.1	+	26	9765	c.9538C>T	c.(9538-9540)Ctt>Ttt	p.L3180F	BRCA2_ENST00000380152.3_Missense_Mutation_p.L3180F	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3180					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGAAAACAAGCTTATGCATAT	0.378			"D, Mis, N, F, S"		"breast, ovarian, pancreatic"	"breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			79	130					0	0	1	0	0	T	32971071	C	T	32971071	3	4	48	1	0	0	0	0	1	0	0	0	1501	797	28	3	9636	3	BRCA2	13	32971071	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	59311	32971071	82198807	3065	7459										
BRCA2	675	broad.mit.edu	37	chr13	32972843	32972843	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagaacaggagagttcccAggccagtacggaagaatgtg	13	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:32972843A>G	ENST00000544455.1	+	27	10420	c.10193A>G	c.(10192-10194)cAg>cGg	p.Q3398R	BRCA2_ENST00000380152.3_Missense_Mutation_p.Q3398R	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3398					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAGAGTTCCCAGGCCAGTACG	0.398			"D, Mis, N, F, S"		"breast, ovarian, pancreatic"	"breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			22	47					0	0	1	0	0	G	32972843	A	G	32972843	3	3	48	1	0	0	0	0	1	0	0	0	1501	188	7	4	10295	4	BRCA2	13	32972843	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1772	32972843	82197035	3066	7460										
N4BP2L2	10443	broad.mit.edu	37	chr13	33109973	33109973	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtaacttctgcaatttatTtaacttttcctcttgaaact	3	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:33109973T>G	ENST00000267068.3	-	2	1356	c.1192A>C	c.(1192-1194)Aat>Cat	p.N398H	N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000446957.2_Missense_Mutation_p.N398H|N4BP2L2_ENST00000399396.3_Intron|N4BP2L2_ENST00000357505.6_Intron	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	398										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TGCAATTTATTTAACTTTTCC	0.373													6	76					0	0	1	0	0	G	33109973	T	G	33109973	3	3	48	1	0	0	0	0	1	0	0	0	10159	1841	64	4	2440	4	N4BP2L2	13	33109973	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	137130	33109973	82059905	3067	7461										
N4BP2L2	10443	broad.mit.edu	37	chr13	33110531	33110531	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaggttttaagagaccatTattatgaccctcataaaatg	6	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:33110531T>G	ENST00000267068.3	-	2	798	c.634A>C	c.(634-636)Aat>Cat	p.N212H	N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000446957.2_Missense_Mutation_p.N212H|N4BP2L2_ENST00000399396.3_Intron|N4BP2L2_ENST00000357505.6_Intron	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	212										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AAGAGACCATTATTATGACCC	0.348													19	39					0	0	1	0	0	G	33110531	T	G	33110531	3	3	48	1	0	0	0	0	1	0	0	0	10159	1754	61	4	2998	4	N4BP2L2	13	33110531	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	558	33110531	82059347	3068	7462										
N4BP2L2	10443	broad.mit.edu	37	chr13	33111120	33111120	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtggctcactcgttacttcTtctctaggtcccaagaattt	7	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:33111120T>G	ENST00000267068.3	-	2	209	c.45A>C	c.(43-45)gaA>gaC	p.E15D	N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000446957.2_Missense_Mutation_p.E15D|N4BP2L2_ENST00000399396.3_Intron|N4BP2L2_ENST00000357505.6_Intron	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	15										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TCGTTACTTCTTCTCTAGGTC	0.313													12	26					0	0	1	0	0	G	33111120	T	G	33111120	3	3	48	1	0	0	0	0	1	0	0	0	10159	1606	56	4	3587	4	N4BP2L2	13	33111120	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	589	33111120	82058758	3069	7463										
PDS5B	23047	broad.mit.edu	37	chr13	33316752	33316752	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggctattaaaatgatggtTcgatggctacttggaatgaa	11	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:33316752T>C	ENST00000315596.10	+	23	2685	c.2499T>C	c.(2497-2499)gtT>gtC	p.V833V		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	833					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AAATGATGGTTCGATGGCTAC	0.308													17	34					0	0	1	0	0	C	33316752	T	C	33316752	2	2	48	1	0	0	0	0	0	0	0	1	11738	1770	62	4		4	PDS5B	13	33316752	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	205632	33316752	81853126	3070	7464										
PDS5B	23047	broad.mit.edu	37	chr13	33332303	33332303	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatcagaaagatggtagaAaatattaaacaaacaaaaga	6	3	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:33332303A>C	ENST00000315596.10	+	27	3321	c.3135A>C	c.(3133-3135)gaA>gaC	p.E1045D		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	1045					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGATGGTAGAAAATATTAAAC	0.264													15	27					0	0	1	0	0	C	33332303	A	C	33332303	3	2	48	1	0	0	0	0	1	0	0	0	11738	11	1	4	3237	4	PDS5B	13	33332303	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	15551	33332303	81837575	3071	7465										
STARD13	90627	broad.mit.edu	37	chr13	33703873	33703873	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgcaggcaggtggcggcGaattctggagatctccattt	13	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:33703873G>A	ENST00000336934.5	-	5	1057	c.941C>T	c.(940-942)tCg>tTg	p.S314L	STARD13_ENST00000255486.4_Missense_Mutation_p.S306L|STARD13_ENST00000399365.3_Missense_Mutation_p.S196L	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	314					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGGTGGCGGCGAATTCTGGAG	0.602													35	64					0	0	1	0	0	A	33703873	G	A	33703873	3	1	48	1	0	0	0	0	1	0	0	0	15311	1059	37	1	2440	1	STARD13	13	33703873	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	371570	33703873	81466005	3072	7466										
CCNA1	8900	broad.mit.edu	37	chr13	37011779	37011779	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttaggggatcacaagaaTcaggtgttattctggatcag	11	5	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:37011779T>G	ENST00000418263.1	+	3	658	c.308T>G	c.(307-309)aTc>aGc	p.I103S	CCNA1_ENST00000440264.1_Missense_Mutation_p.I60S|CCNA1_ENST00000463403.1_3'UTR|CCNA1_ENST00000255465.4_Missense_Mutation_p.I104S|CCNA1_ENST00000449823.1_Missense_Mutation_p.I60S	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	104					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ATCACAAGAATCAGGTGTTAT	0.483													34	71					0	0	1	0	0	G	37011779	T	G	37011779	3	3	48	1	0	0	0	0	1	0	0	0	2931	1435	50	4	321	4	CCNA1	13	37011779	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3307906	37011779	78158099	3073	7467										
POSTN	10631	broad.mit.edu	37	chr13	38160307	38160307	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actttgtctcccatgatcctTtctaggacacctcgtggaag	8	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:38160307T>G	ENST00000379747.4	-	7	981	c.864A>C	c.(862-864)gaA>gaC	p.E288D	POSTN_ENST00000541481.1_Missense_Mutation_p.E288D|POSTN_ENST00000541179.1_Missense_Mutation_p.E288D|POSTN_ENST00000379743.4_Missense_Mutation_p.E288D|POSTN_ENST00000379749.4_Missense_Mutation_p.E288D|POSTN_ENST00000379742.4_Missense_Mutation_p.E288D	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	288	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CCATGATCCTTTCTAGGACAC	0.468													30	31					0	0	1	0	0	G	38160307	T	G	38160307	3	3	48	1	0	0	0	0	1	0	0	0	12306	1838	64	4	1714	4	POSTN	13	38160307	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1148528	38160307	77009571	3074	7468										
TRPC4	7223	broad.mit.edu	37	chr13	38211329	38211329	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagattccagttgaatatttCtctcaagtggtcctgcagcc	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:38211329C>A	ENST00000379705.3	-	11	3502	c.2645G>T	c.(2644-2646)aGa>aTa	p.R882I	TRPC4_ENST00000338947.5_Missense_Mutation_p.R709I|TRPC4_ENST00000379681.3_Missense_Mutation_p.R887I|TRPC4_ENST00000379679.1_Missense_Mutation_p.R709I|TRPC4_ENST00000358477.2_Missense_Mutation_p.R798I|TRPC4_ENST00000447043.1_Missense_Mutation_p.R741I|TRPC4_ENST00000355779.2_Missense_Mutation_p.R741I|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379673.2_Missense_Mutation_p.R733I			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	882	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTGAATATTTCTCTCAAGTGG	0.438													13	41					2.27111e-07	2.60515e-07	1	1	0	A	38211329	C	A	38211329	3	1	48	1	0	0	0	0	1	0	0	0	16640	913	32	2	292	2	TRPC4	13	38211329	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	51022	38211329	76958549	3075	7469										
TRPC4	7223	broad.mit.edu	37	chr13	38320162	38320162	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactattgtcatctcggtaaTtaagaatgatttccagttct	7	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:38320162T>G	ENST00000379705.3	-	3	1666	c.809A>C	c.(808-810)aAt>aCt	p.N270T	TRPC4_ENST00000338947.5_Intron|TRPC4_ENST00000379681.3_Missense_Mutation_p.N270T|TRPC4_ENST00000379679.1_Intron|TRPC4_ENST00000358477.2_Missense_Mutation_p.N270T|TRPC4_ENST00000447043.1_Missense_Mutation_p.N270T|TRPC4_ENST00000355779.2_Missense_Mutation_p.N270T|TRPC4_ENST00000426868.2_Missense_Mutation_p.N270T|TRPC4_ENST00000379673.2_Missense_Mutation_p.N270T			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	270	Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ATCTCGGTAATTAAGAATGAT	0.413													10	125					0	0	1	0	0	G	38320162	T	G	38320162	3	3	48	1	0	0	0	0	1	0	0	0	16640	1493	52	4	2175	4	TRPC4	13	38320162	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	108833	38320162	76849716	3076	7470										
FREM2	341640	broad.mit.edu	37	chr13	39264612	39264612	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatatgtctcaagaatggaGaattggtggcaatactatcc	10	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:39264612G>A	ENST00000280481.7	+	1	3347	c.3131G>A	c.(3130-3132)aGa>aAa	p.R1044K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1044					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.R1044I(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAAGAATGGAGAATTGGTGGC	0.448													12	118					0	0	1	0	0	A	39264612	G	A	39264612	3	1	48	1	0	0	0	0	1	0	0	0	6079	942	33	3	3133	3	FREM2	13	39264612	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	944450	39264612	75905266	3077	7471										
FREM2	341640	broad.mit.edu	37	chr13	39265586	39265586	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaatatcacactgggcatgAattttacccaggatgaagta	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:39265586A>C	ENST00000280481.7	+	1	4321	c.4105A>C	c.(4105-4107)Aat>Cat	p.N1369H		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1369					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACTGGGCATGAATTTTACCCA	0.393													20	45					0	0	1	0	0	C	39265586	A	C	39265586	3	2	48	1	0	0	0	0	1	0	0	0	6079	246	9	4	4107	4	FREM2	13	39265586	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	974	39265586	75904292	3078	7472										
NHLRC3	387921	broad.mit.edu	37	chr13	39616246	39616246	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatctatctttataggattCtttggtcatactgttaaaaa	5	5	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:39616246C>A	ENST00000379600.3	+	4	712	c.390C>A	c.(388-390)ttC>ttA	p.F130L	NHLRC3_ENST00000379599.2_Intron|NHLRC3_ENST00000470258.1_5'UTR	NM_001012754.2	NP_001012772.1	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3	130						extracellular region		p.F130L(1)		breast(1)|kidney(1)|large_intestine(3)|lung(4)|skin(2)	11		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TTATAGGATTCTTTGGTCATA	0.318													15	18					3.27435e-08	3.83577e-08	1	1	0	A	39616246	C	A	39616246	3	1	48	1	0	0	0	0	1	0	0	0	10453	912	32	2	404	2	NHLRC3	13	39616246	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	350660	39616246	75553632	3079	7473										
COG6	57511	broad.mit.edu	37	chr13	40261896	40261896	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagctactgcttctgaaaaGgaacaccttgaagctctctt	7	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:40261896G>T	ENST00000416691.1	+	10	1069	c.969G>T	c.(967-969)aaG>aaT	p.K323N	COG6_ENST00000455146.3_Missense_Mutation_p.K323N	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	323					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		CTTCTGAAAAGGAACACCTTG	0.368													10	31					0.0581538	0.0589718	1	1	0	T	40261896	G	T	40261896	3	4	48	1	0	0	0	0	1	0	0	0	3685	991	35	5	1007	5	COG6	13	40261896	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	645650	40261896	74907982	3080	7474										
KBTBD6	89890	broad.mit.edu	37	chr13	41706285	41706285	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtcgaccaacacctcgaaGgactcggcgtccacatcgtg	10	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:41706285G>T	ENST00000379485.1	-	1	597	c.363C>A	c.(361-363)tcC>tcA	p.S121S	KBTBD6_ENST00000499385.2_Silent_p.S55S	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	121	BTB.						protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ACACCTCGAAGGACTCGGCGT	0.602													23	42					1.75199e-13	2.24662e-13	1	1	0	T	41706285	G	T	41706285	2	4	48	1	0	0	0	0	0	0	0	1	8040	987	35	5		5	KBTBD6	13	41706285	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1444389	41706285	73463593	3081	7475										
KBTBD6	89890	broad.mit.edu	37	chr13	41706525	41706525	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgcagaatgggccgtgtcCtttaattcctctggacccgt	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:41706525C>A	ENST00000379485.1	-	1	357	c.123G>T	c.(121-123)aaG>aaT	p.K41N	KBTBD6_ENST00000499385.2_Missense_Mutation_p.K41N	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	41							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		GGGCCGTGTCCTTTAATTCCT	0.607													81	138					2.28164e-27	3.2341e-27	1	1	0	A	41706525	C	A	41706525	3	1	48	1	0	0	0	0	1	0	0	0	8040	680	24	5	1905	5	KBTBD6	13	41706525	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	240	41706525	73463353	3082	7476										
KBTBD7	84078	broad.mit.edu	37	chr13	41767897	41767897	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttggtcaggtcaagacgtCgggctaagaaggaggcacag	16	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:41767897C>T	ENST00000379483.3	-	1	805	c.497G>A	c.(496-498)cGa>cAa	p.R166Q		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	166							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GTCAAGACGTCGGGCTAAGAA	0.572													38	64					0	0	1	0	0	T	41767897	C	T	41767897	3	4	48	1	0	0	0	0	1	0	0	0	8041	884	31	1	1561	1	KBTBD7	13	41767897	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	61372	41767897	73401981	3083	7477										
MTRF1	9617	broad.mit.edu	37	chr13	41834816	41834816	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaggttctccatatatttCtgtagtgctttatgcttcca	6	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:41834816C>A	ENST00000379480.4	-	2	328	c.228G>T	c.(226-228)caG>caT	p.Q76H	MTRF1_ENST00000430347.2_Missense_Mutation_p.Q89H|MTRF1_ENST00000379477.1_Missense_Mutation_p.Q76H|MTRF1_ENST00000239852.6_5'UTR	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	76					regulation of translational termination	mitochondrion	translation release factor activity, codon specific			breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		CCATATATTTCTGTAGTGCTT	0.423													19	93					1.01871e-10	1.25646e-10	1	1	0	A	41834816	C	A	41834816	3	1	48	1	0	0	0	0	1	0	0	0	10006	912	32	2	1145	2	MTRF1	13	41834816	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	66919	41834816	73335062	3084	7478										
NAA16	79612	broad.mit.edu	37	chr13	41933048	41933048	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgtgcaaaatacatgcttCgagcaaatatgataaaagaa	7	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:41933048C>T	ENST00000379406.3	+	12	1684	c.1360C>T	c.(1360-1362)Cga>Tga	p.R454*	NAA16_ENST00000379367.3_Nonsense_Mutation_p.R454*	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	454					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding	p.R454*(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						ATACATGCTTCGAGCAAATAT	0.378													25	48					0	0	1	0	0	T	41933048	C	T	41933048	4	4	48	1	0	0	0	0	0	1	0	0	10166	876	31	1	1439	1	NAA16	13	41933048	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	98232	41933048	73236830	3085	7479										
NAA16	79612	broad.mit.edu	37	chr13	41943339	41943339	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagagaacgtcaacagaaaAatcaaaagaaaaaaagagat	7	4	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:41943339A>C	ENST00000379406.3	+	15	2191	c.1867A>C	c.(1867-1869)Aat>Cat	p.N623H	NAA16_ENST00000497143.1_3'UTR	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	623					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						tcaacagaaaaatcaaaagaa	0.358													20	27					0	0	1	0	0	C	41943339	A	C	41943339	3	2	48	1	0	0	0	0	1	0	0	0	10166	14	1	4	1958	4	NAA16	13	41943339	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	10291	41943339	73226539	3086	7480										
TSC22D1	8848	broad.mit.edu	37	chr13	45010884	45010884	+	Translation_Start_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacagaaaacggcagccctAatttaaagaaacccagcttc	6	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:45010884A>C	ENST00000261489.2	-	0	97				TSC22D1_ENST00000501704.2_Intron|TSC22D1_ENST00000458659.2_Intron	NM_006022.3	NP_006013.1	Q15714	T22D1_HUMAN	TSC22 domain family, member 1						transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CGGCAGCCCTAATTTAAAGAA	0.537													12	43					0	0	1	0	0	C	45010884	A	C	45010884	1	2	48	1	0	0	0	0	0	0	0	0	16667	377	13	4		4	TSC22D1	13	45010884	Translation_Start_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3067545	45010884	70158994	3087	7481										
TSC22D1	8848	broad.mit.edu	37	chr13	45148935	45148935	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttcatagaactcagtgcAagtccatctaccttttttaa	4	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:45148935A>G	ENST00000458659.2	-	1	1766	c.1276T>C	c.(1276-1278)Tgc>Cgc	p.C426R	TSC22D1_ENST00000501704.2_Missense_Mutation_p.C426R	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	426					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		AACTCAGTGCAAGTCCATCTA	0.403													33	48					0	0	1	0	0	G	45148935	A	G	45148935	3	3	48	1	0	0	0	0	1	0	0	0	16667	130	5	4	2086	4	TSC22D1	13	45148935	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	138051	45148935	70020943	3088	7482										
KCTD4	386618	broad.mit.edu	37	chr13	45768375	45768375	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaattctgcttcttgtgcaaGaagttgattttctcgaaacc	8	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:45768375G>T	ENST00000405872.1	-	2	731	c.328C>A	c.(328-330)Ctt>Att	p.L110I	KCTD4_ENST00000379108.1_Missense_Mutation_p.L110I|GTF2F2_ENST00000340473.6_Intron	NM_198404.2	NP_940686.2	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerization domain containing 4	110	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		TCTTGTGCAAGAAGTTGATTT	0.443													30	54					1.2476e-16	1.66396e-16	1	1	0	T	45768375	G	T	45768375	3	4	48	1	0	0	0	0	1	0	0	0	8154	942	33	2	455	2	KCTD4	13	45768375	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	619440	45768375	69401503	3089	7483										
SPERT	220082	broad.mit.edu	37	chr13	46276932	46276933	+	Frame_Shift_Ins	INS	-	-	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaaggccaaattatacaagINSaaaaagagataccagatctg							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:46276932_46276933insA	ENST00000310521.1	+	2	178_179	c.98_99insA	c.(97-99)aaafs	p.K33fs		NM_152719.1	NP_689932.1	Q8NA61	SPERT_HUMAN	spermatid associated	33						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		AATTATACAAGAAAAAGAGATA	0.426													9	22	---	---	---	---						A	46276933	-	A	46276932	7	5	48	1	0	1	1	0	0	0	0	0	15094	942	33	0	104	0	SPERT	13	46276932	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	508557	46276932	68892946	3090	7484										
MED4	29079	broad.mit.edu	37	chr13	48654089	48654089	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctcatctctaaatcagtTgggtagggtctccgggggtc	12	10	4	0	rs149158920	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:48654089T>C	ENST00000258648.2	-	6	556	c.531A>G	c.(529-531)ccA>ccG	p.P177P	MED4_ENST00000495013.1_5'UTR|MED4-AS1_ENST00000422483.1_RNA|MED4_ENST00000378586.1_Silent_p.P131P	NM_014166.2	NP_054885.1	Q9NPJ6	MED4_HUMAN	mediator complex subunit 4	177					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)	8		all_cancers(8;2.93e-25)|all_epithelial(8;4.38e-13)|all_lung(13;7.37e-06)|all_hematologic(8;8.61e-05)|Breast(56;0.000141)|Lung NSC(96;0.000518)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.00559)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;5.18e-07)		CTAAATCAGTTGGGTAGGGTC	0.388													17	37					0	0	1	0	0	C	48654089	T	C	48654089	2	2	48	1	0	0	0	0	0	0	0	1	9499	1799	63	4		4	MED4	13	48654089	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2377157	48654089	66515789	3091	7485										
RB1	5925	broad.mit.edu	37	chr13	48937070	48937070	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttattgaagttctctgtaaaGaacatgaatgtaatatagat	7	3	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:48937070G>T	ENST00000267163.4	+	8	976	c.838G>T	c.(838-840)Gaa>Taa	p.E280*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	280					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.E280*(2)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTCTGTAAAGAACATGAATG	0.333		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			22	41					1.28384e-07	1.48174e-07	1	1	0	T	48937070	G	T	48937070	4	4	48	1	0	0	0	0	0	1	0	0	13149	943	33	2	868	2	RB1	13	48937070	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	282981	48937070	66232808	3092	7486										
RB1	5925	broad.mit.edu	37	chr13	48955517	48955517	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaaggcaacttgacaagaGaaatgataaaacatttagaa	8	5	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:48955517G>T	ENST00000267163.4	+	17	1771	c.1633G>T	c.(1633-1635)Gaa>Taa	p.E545*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	545	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTGACAAGAGAAATGATAAA	0.338		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			8	22					0.0381472	0.0387537	1	1	0	T	48955517	G	T	48955517	4	4	48	1	0	0	0	0	0	1	0	0	13149	943	33	2	1699	2	RB1	13	48955517	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	18447	48955517	66214361	3093	7487										
CYSLTR2	57105	broad.mit.edu	37	chr13	49281071	49281071	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaaaacttcaagagagaaTttttcccaattgtatatctg	6	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:49281071T>G	ENST00000282018.3	+	1	121	c.118T>G	c.(118-120)Ttt>Gtt	p.F40V		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	40					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	CAAGAGAGAATTTTTCCCAAT	0.398													16	36					0	0	1	0	0	G	49281071	T	G	49281071	3	3	48	1	0	0	0	0	1	0	0	0	4225	1493	52	4	120	4	CYSLTR2	13	49281071	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	325554	49281071	65888807	3094	7488										
FNDC3A	22862	broad.mit.edu	37	chr13	49776035	49776035	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcaagcttgtaatgaagcTggggaaggtcccctctccca	10	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:49776035T>C	ENST00000492622.2	+	24	3392	c.3087T>C	c.(3085-3087)gcT>gcC	p.A1029A	FNDC3A_ENST00000541916.1_Silent_p.A1029A|FNDC3A_ENST00000398316.3_Silent_p.A973A	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1029	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GTAATGAAGCTGGGGAAGGTC	0.373													12	21					0	0	1	0	0	C	49776035	T	C	49776035	2	2	48	1	0	0	0	0	0	0	0	1	6001	1567	55	4		4	FNDC3A	13	49776035	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	494964	49776035	65393843	3095	7489										
CDADC1	81602	broad.mit.edu	37	chr13	49841919	49841919	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaataaaagaatatgaaatgTtatttttggtttcaaatgaa	7	1	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:49841919T>A	ENST00000251108.6	+	5	837	c.724T>A	c.(724-726)Tta>Ata	p.L242I	CDADC1_ENST00000444959.1_Missense_Mutation_p.L44I	NM_001193478.1|NM_030911.3	NP_001180407.1|NP_112173.1	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	242							hydrolase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	16		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		ATATGAAATGTTATTTTTGGT	0.289													6	15					0	0	1	0	0	A	49841919	T	A	49841919	3	1	48	1	0	0	0	0	1	0	0	0	3075	1722	60	4	742	4	CDADC1	13	49841919	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	65884	49841919	65327959	3096	7490										
ARL11	115761	broad.mit.edu	37	chr13	50204716	50204716	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggagaccctgcccactgttGgtttcaacgtggagcctctg	12	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:50204716G>T	ENST00000282026.1	+	2	468	c.133G>T	c.(133-135)Ggt>Tgt	p.G45C	ARL11_ENST00000490932.1_Intron	NM_138450.5	NP_612459.1	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	45					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding			kidney(1)|large_intestine(4)|ovary(1)	6		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		GCCCACTGTTGGTTTCAACGT	0.622													28	56					4.22769e-11	5.2466e-11	1	1	0	T	50204716	G	T	50204716	3	4	48	1	0	0	0	0	1	0	0	0	924	1348	47	5	135	5	ARL11	13	50204716	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	362797	50204716	64965162	3097	7491										
CCDC70	83446	broad.mit.edu	37	chr13	52439882	52439882	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagagaaaactttctggaAaaagtaccgcactttctgga	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:52439882A>C	ENST00000242819.4	+	2	664	c.368A>C	c.(367-369)aAa>aCa	p.K123T		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	123						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		ACTTTCTGGAAAAAGTACCGC	0.468													65	118					0	0	1	0	0	C	52439882	A	C	52439882	3	2	48	1	0	0	0	0	1	0	0	0	2863	14	1	4	370	4	CCDC70	13	52439882	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2235166	52439882	62729996	3098	7492										
ATP7B	540	broad.mit.edu	37	chr13	52548571	52548571	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacaatgcattccatctattCtcagttggagggtgaccaca	8	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:52548571C>A	ENST00000242839.4	-	2	941	c.785G>T	c.(784-786)aGa>aTa	p.R262I	ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400370.3_Missense_Mutation_p.R262I|ATP7B_ENST00000400366.3_Missense_Mutation_p.R262I|ATP7B_ENST00000418097.2_Missense_Mutation_p.R262I|ATP7B_ENST00000542656.1_Missense_Mutation_p.R230I|ATP7B_ENST00000344297.5_Missense_Mutation_p.R262I|ATP7B_ENST00000448424.2_Missense_Mutation_p.R262I	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	262	HMA 3.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TCCATCTATTCTCAGTTGGAG	0.418									Wilson disease				24	66					2.52088e-20	3.4514e-20	1	1	0	A	52548571	C	A	52548571	3	1	48	1	0	0	0	0	1	0	0	0	1189	913	32	2	3692	2	ATP7B	13	52548571	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	108689	52548571	62621307	3099	7493										
UTP14C	9724	broad.mit.edu	37	chr13	52604309	52604309	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagccaggaggtgctgtccGaattgagggcactatctcag	14	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:52604309G>A	ENST00000521776.2	+	2	2102	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	457					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome		p.E457K(1)		breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		GGTGCTGTCCGAATTGAGGGC	0.483													50	101					0	0	1	0	0	A	52604309	G	A	52604309	3	1	48	1	0	0	0	0	1	0	0	0	17155	1059	37	1	1371	1	UTP14C	13	52604309	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	55738	52604309	62565569	3100	7494										
THSD1	55901	broad.mit.edu	37	chr13	52971819	52971819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagttctgtccttttgctgGttcttatttccagcggctgt	9	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:52971819G>A	ENST00000349258.4	-	3	1113	c.569C>T	c.(568-570)aCc>aTc	p.T190I	THSD1_ENST00000544466.1_Intron|THSD1_ENST00000258613.4_Missense_Mutation_p.T190I	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	190						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CCTTTTGCTGGTTCTTATTTC	0.517													15	38					0	0	1	0	0	A	52971819	G	A	52971819	3	1	48	1	0	0	0	0	1	0	0	0	15936	1261	44	3	2001	3	THSD1	13	52971819	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	367510	52971819	62198059	3101	7495										
THSD1	55901	broad.mit.edu	37	chr13	52976790	52976790	+	Translation_Start_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgtcctttctcacgtccaGattgtgatttttttccccaa	5	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:52976790G>T	ENST00000349258.4	-	0	490				THSD1_ENST00000544466.1_Intron|THSD1_ENST00000258613.4_De_novo_Start_OutOfFrame	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1							extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CTCACGTCCAGATTGTGATTT	0.343													10	15					9.70103e-10	1.17791e-09	1	1	0	T	52976790	G	T	52976790	1	4	48	1	0	0	0	0	0	0	0	0	15936	957	33	2		2	THSD1	13	52976790	Translation_Start_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4971	52976790	62193088	3102	7496										
PCDH8	5100	broad.mit.edu	37	chr13	53419685	53419685	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttctctgcttctctgccaGaaatggtgttgaaggagtgt	11	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:53419685G>T	ENST00000377942.3	-	2	2917	c.2714C>A	c.(2713-2715)tCt>tAt	p.S905Y	PCDH8_ENST00000338862.4_Missense_Mutation_p.S808Y	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	905					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTCTCTGCCAGAAATGGTGTT	0.577													5	54					0.014758	0.015099	1	1	0	T	53419685	G	T	53419685	3	4	48	1	0	0	0	0	1	0	0	0	11563	942	33	2	506	2	PCDH8	13	53419685	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	442895	53419685	61750193	3103	7497										
PCDH17	27253	broad.mit.edu	37	chr13	58206862	58206862	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcggagggcgcagcaagtCgggtagctaccgggtgctgg	20	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:58206862C>T	ENST00000377918.3	+	1	208	c.182C>T	c.(181-183)tCg>tTg	p.S61L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	61	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGCAGCAAGTCGGGTAGCTAC	0.692													14	26					0	0	1	0	0	T	58206862	C	T	58206862	3	4	48	1	0	0	0	0	1	0	0	0	11558	893	31	1	184	1	PCDH17	13	58206862	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4787177	58206862	56963016	3104	7498										
PCDH20	64881	broad.mit.edu	37	chr13	61986041	61986041	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcattgatatctagaaggaGaattgtgatttttgctgtag	11	3	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:61986041G>T	ENST00000409186.1	-	5	4296	c.2191C>A	c.(2191-2193)Ctc>Atc	p.L731I	PCDH20_ENST00000409204.4_Missense_Mutation_p.L731I			Q8N6Y1	PCD20_HUMAN	protocadherin 20	704	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TCTAGAAGGAGAATTGTGATT	0.463													50	84					4.01344e-20	5.48555e-20	1	1	0	T	61986041	G	T	61986041	3	4	48	1	0	0	0	0	1	0	0	0	11561	942	33	2	668	2	PCDH20	13	61986041	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3779179	61986041	53183837	3105	7499										
PCDH20	64881	broad.mit.edu	37	chr13	61987061	61987061	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgagcttgtgggactccaGaacacttcctccaatcttac	9	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:61987061G>A	ENST00000409186.1	-	5	3276	c.1171C>T	c.(1171-1173)Ctg>Ttg	p.L391L	PCDH20_ENST00000409204.4_Silent_p.L391L			Q8N6Y1	PCD20_HUMAN	protocadherin 20	364	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TGGGACTCCAGAACACTTCCT	0.423													41	72					0	0	1	0	0	A	61987061	G	A	61987061	2	1	48	1	0	0	0	0	0	0	0	1	11561	933	33	3		3	PCDH20	13	61987061	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1020	61987061	53182817	3106	7500										
PCDH20	64881	broad.mit.edu	37	chr13	61987509	61987509	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgataggtctgtaccccattAatgcctacatctgggtccac	8	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:61987509A>C	ENST00000409186.1	-	5	2828	c.723T>G	c.(721-723)atT>atG	p.I241M	PCDH20_ENST00000409204.4_Missense_Mutation_p.I241M			Q8N6Y1	PCD20_HUMAN	protocadherin 20	214	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GTACCCCATTAATGCCTACAT	0.532													47	79					0	0	1	0	0	C	61987509	A	C	61987509	3	2	48	1	0	0	0	0	1	0	0	0	11561	358	13	4	2136	4	PCDH20	13	61987509	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	448	61987509	53182369	3107	7501										
PCDH9	5101	broad.mit.edu	37	chr13	67802265	67802265	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacactcattctcctcagcaTatgaggcgccagcacagagt	8	13	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:67802265T>G	ENST00000544246.1	-	2	999	c.308A>C	c.(307-309)tAt>tCt	p.Y103S	PCDH9_ENST00000377861.3_Missense_Mutation_p.Y103S|PCDH9_ENST00000328454.5_Missense_Mutation_p.Y103S|PCDH9_ENST00000456367.1_Missense_Mutation_p.Y103S|PCDH9_ENST00000377865.2_Missense_Mutation_p.Y103S	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	103	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CTCCTCAGCATATGAGGCGCC	0.438													25	46					0	0	1	0	0	G	67802265	T	G	67802265	3	3	48	1	0	0	0	0	1	0	0	0	11564	1406	49	4	3421	4	PCDH9	13	67802265	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	5814756	67802265	47367613	3108	7502										
PCDH9	5101	broad.mit.edu	37	chr13	67802555	67802555	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcagagcagccaacaggtaAaaatccctcaggtccatgat	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:67802555A>C	ENST00000544246.1	-	2	709	c.18T>G	c.(16-18)ttT>ttG	p.F6L	PCDH9_ENST00000377861.3_Missense_Mutation_p.F6L|PCDH9_ENST00000328454.5_Missense_Mutation_p.F6L|PCDH9_ENST00000456367.1_Missense_Mutation_p.F6L|PCDH9_ENST00000377865.2_Missense_Mutation_p.F6L	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	6					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CCAACAGGTAAAAATCCCTCA	0.398													5	39					0	0	1	0	0	C	67802555	A	C	67802555	3	2	48	1	0	0	0	0	1	0	0	0	11564	11	1	4	3711	4	PCDH9	13	67802555	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	290	67802555	47367323	3109	7503										
PIBF1	10464	broad.mit.edu	37	chr13	73467988	73467988	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccatcaaagtaaattaaaAtcttttgaaagtgagcgtgt	7	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:73467988A>C	ENST00000326291.6	+	11	1727	c.1389A>C	c.(1387-1389)aaA>aaC	p.K463N		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	463						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GTAAATTAAAATCTTTTGAAA	0.348													13	32					0	0	1	0	0	C	73467988	A	C	73467988	3	2	48	1	0	0	0	0	1	0	0	0	11926	98	4	4	1427	4	PIBF1	13	73467988	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5665433	73467988	41701890	3110	7504										
FBXL3	26224	broad.mit.edu	37	chr13	77581885	77581885	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggtagttcagggctagttCtcttaagccgtgacactgat	12	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:77581885C>A	ENST00000355619.5	-	5	1006	c.682G>T	c.(682-684)Gaa>Taa	p.E228*	FBXL3_ENST00000477982.1_Intron	NM_012158.2	NP_036290.1	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	228					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|urinary_tract(1)	16		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		AGGGCTAGTTCTCTTAAGCCG	0.343													4	36					2.56e-06	2.86294e-06	1	1	0	A	77581885	C	A	77581885	4	1	48	1	0	0	0	0	0	1	0	0	5752	922	32	2	608	2	FBXL3	13	77581885	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4113897	77581885	37587993	3111	7505										
SCEL	8796	broad.mit.edu	37	chr13	78130826	78130826	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacaggataacagttggataAagaaacgccctgaagaagaa	10	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:78130826A>C	ENST00000535157.1	+	3	309	c.139A>C	c.(139-141)Aag>Cag	p.K47Q	SCEL_ENST00000377246.3_Missense_Mutation_p.K47Q|SCEL_ENST00000349847.3_Missense_Mutation_p.K47Q	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	47					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		CAGTTGGATAAAGAAACGCCC	0.468													16	126					0	0	1	0	0	C	78130826	A	C	78130826	3	2	48	1	0	0	0	0	1	0	0	0	13940	15	1	4	145	4	SCEL	13	78130826	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	548941	78130826	37039052	3112	7506										
SCEL	8796	broad.mit.edu	37	chr13	78173503	78173503	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcttcagagcaaatccaaaGgtagaagaaagagagaaaag	10	6	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:78173503G>T	ENST00000535157.1	+	13	941	c.771G>T	c.(769-771)aaG>aaT	p.K257N	SCEL_ENST00000469982.1_Intron|SCEL_ENST00000377246.3_Missense_Mutation_p.K259N|SCEL_ENST00000349847.3_Missense_Mutation_p.K279N	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	279	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		CAAATCCAAAGGTAGAAGAAA	0.368													9	21					7.48243e-07	8.49459e-07	1	1	0	T	78173503	G	T	78173503	3	4	48	1	0	0	0	0	1	0	0	0	13940	991	35	5	887	5	SCEL	13	78173503	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42677	78173503	36996375	3113	7507										
SCEL	8796	broad.mit.edu	37	chr13	78202083	78202083	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatatatttttttccttagaGaccagaacctggaaaattta	5	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:78202083G>A	ENST00000535157.1	+	26	1674	c.1502_splice	c.e26-1	p.D502_splice	SCEL_ENST00000377246.3_Splice_Site_p.D524_splice|SCEL_ENST00000349847.3_Splice_Site_p.D544_splice	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	544	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		TTTCCTTAGAGACCAGAACCT	0.249													14	15					0	0	1	0	0	A	78202083	G	A	78202083	5	1	48	1	0	0	0	0	0	0	1	0	13940	956	33	3	1736	3	SCEL	13	78202083	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	28580	78202083	36967795	3114	7508										
RNF219	79596	broad.mit.edu	37	chr13	79213182	79213182	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcttaagctcttctacttCtttctgtaaacaatctattt	2	10	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:79213182C>A	ENST00000282003.6	-	4	383	c.325G>T	c.(325-327)Gaa>Taa	p.E109*		NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	109							zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TCTTCTACTTCTTTCTGTAAA	0.383													11	38					3.86212e-05	4.21111e-05	1	1	0	A	79213182	C	A	79213182	4	1	48	1	0	0	0	0	0	1	0	0	13533	922	32	2	1867	2	RNF219	13	79213182	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1011099	79213182	35956696	3115	7509										
SLITRK1	114798	broad.mit.edu	37	chr13	84454060	84454060	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggagcactcccaggggtttCcgtggaggtctatctggatg	15	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:84454060C>T	ENST00000377084.2	-	1	2468	c.1583G>A	c.(1582-1584)gGa>gAa	p.G528E		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	528						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCAGGGGTTTCCGTGGAGGTC	0.552													25	37					0	0	1	0	0	T	84454060	C	T	84454060	3	4	48	1	0	0	0	0	1	0	0	0	14795	855	30	3	511	3	SLITRK1	13	84454060	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5240878	84454060	30715818	3116	7510										
SLITRK1	114798	broad.mit.edu	37	chr13	84454778	84454778	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcccatttgtcttgaaagGagttggcaggggtccaggag	15	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:84454778G>T	ENST00000377084.2	-	1	1750	c.865C>A	c.(865-867)Cct>Act	p.P289T		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	289						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTCTTGAAAGGAGTTGGCAGG	0.542													14	32					0.000219431	0.000235335	1	1	0	T	84454778	G	T	84454778	3	4	48	1	0	0	0	0	1	0	0	0	14795	1174	41	2	1229	2	SLITRK1	13	84454778	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	718	84454778	30715100	3117	7511										
SLITRK5	26050	broad.mit.edu	37	chr13	88328028	88328028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggggctttccatgggctaCggggtttgaggagattgcat	16	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:88328028C>T	ENST00000325089.6	+	2	604	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	SLITRK5_ENST00000400028.3_Intron	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	129						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCATGGGCTACGGGGTTTGAG	0.448													45	78					0	0	1	0	0	T	88328028	C	T	88328028	3	4	48	1	0	0	0	0	1	0	0	0	14799	527	19	1	387	1	SLITRK5	13	88328028	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3873250	88328028	26841850	3118	7512										
SLITRK5	26050	broad.mit.edu	37	chr13	88330517	88330517	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaccacgtttagccagttCtaaaagcaaagaaactctct	6	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:88330517C>A	ENST00000325089.6	+	2	3093	c.2874C>A	c.(2872-2874)ttC>ttA	p.F958L	SLITRK5_ENST00000400028.3_Missense_Mutation_p.F717L	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	958						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TTAGCCAGTTCTAAAAGCAAA	0.398													31	64					9.65021e-13	1.22324e-12	1	1	0	A	88330517	C	A	88330517	3	1	48	1	0	0	0	0	1	0	0	0	14799	912	32	2	2876	2	SLITRK5	13	88330517	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2489	88330517	26839361	3119	7513										
DCT	1638	broad.mit.edu	37	chr13	95121172	95121172	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgagatctaaggcgcccaaGaactgctctctttcctgagg	11	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:95121172G>T	ENST00000377028.5	-	2	836	c.423C>A	c.(421-423)ttC>ttA	p.F141L	DCT_ENST00000446125.1_Missense_Mutation_p.F141L	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	141					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AGGCGCCCAAGAACTGCTCTC	0.567													98	175					3.26951e-42	4.73095e-42	1	1	0	T	95121172	G	T	95121172	3	4	48	1	0	0	0	0	1	0	0	0	4327	933	33	2	1271	2	DCT	13	95121172	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6790655	95121172	20048706	3120	7514										
TGDS	23483	broad.mit.edu	37	chr13	95231015	95231015	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgctgtagcaaagatataaAttttggaataacctaaaaga	8	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:95231015A>C	ENST00000261296.5	-	8	748	c.628T>G	c.(628-630)Ttt>Gtt	p.F210V	TGDS_ENST00000498294.1_5'UTR	NM_014305.2	NP_055120.1	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	210					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AAAGATATAAATTTTGGAATA	0.274													6	53					0	0	1	0	0	C	95231015	A	C	95231015	3	2	48	1	0	0	0	0	1	0	0	0	15873	101	4	4	444	4	TGDS	13	95231015	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	109843	95231015	19938863	3121	7515										
ABCC4	10257	broad.mit.edu	37	chr13	95847160	95847160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgacggcagctgacggttgCgctgtgatatctcatcaagt	12	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:95847160C>T	ENST00000376887.4	-	9	1307	c.1193G>A	c.(1192-1194)cGc>cAc	p.R398H	ABCC4_ENST00000412704.1_Missense_Mutation_p.R398H|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000536256.1_Missense_Mutation_p.R323H|ABCC4_ENST00000431522.1_Missense_Mutation_p.R398H	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	398					platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CTGACGGTTGCGCTGTGATAT	0.378													5	25					0	0	1	0	0	T	95847160	C	T	95847160	3	4	48	1	0	0	0	0	1	0	0	0	55	768	27	1	2925	1	ABCC4	13	95847160	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	616145	95847160	19322718	3122	7516										
UGGT2	55757	broad.mit.edu	37	chr13	96555127	96555127	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcaataaggaatgttttaAttttatctccagagtaaata	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:96555127A>C	ENST00000376747.3	-	21	2553	c.2483T>G	c.(2482-2484)aTt>aGt	p.I828S		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	828					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						GAATGTTTTAATTTTATCTCC	0.318													19	40					0	0	1	0	0	C	96555127	A	C	96555127	3	2	48	1	0	0	0	0	1	0	0	0	17001	101	4	4	2143	4	UGGT2	13	96555127	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	707967	96555127	18614751	3123	7517										
UGGT2	55757	broad.mit.edu	37	chr13	96589253	96589253	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccatttttagttctttaatAttcatctcttcatgtttaaa	3	7	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:96589253A>C	ENST00000376747.3	-	17	1972	c.1902T>G	c.(1900-1902)aaT>aaG	p.N634K		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	634					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						GTTCTTTAATATTCATCTCTT	0.338													16	55					0	0	1	0	0	C	96589253	A	C	96589253	3	2	48	1	0	0	0	0	1	0	0	0	17001	446	16	4	2740	4	UGGT2	13	96589253	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	34126	96589253	18580625	3124	7518										
STK24	8428	broad.mit.edu	37	chr13	99127579	99127579	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttctcttaatatagtagCgatctgggtttcatctaatg	7	6	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:99127579C>T	ENST00000397517.2	-	4	440	c.364G>A	c.(364-366)Gct>Act	p.A122T	STK24_ENST00000539966.1_Missense_Mutation_p.A103T|STK24_ENST00000376547.3_Missense_Mutation_p.A134T	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	134	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AATATAGTAGCGATCTGGGTT	0.333													10	28					0	0	1	0	0	T	99127579	C	T	99127579	3	4	48	1	0	0	0	0	1	0	0	0	15348	768	27	1	963	1	STK24	13	99127579	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2538326	99127579	16042299	3125	7519										
DOCK9	23348	broad.mit.edu	37	chr13	99667807	99667807	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcacatataagcacagtttCtttcaaaaacggtgcggatg	9	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:99667807C>A	ENST00000448493.2	-	1	166	c.56G>T	c.(55-57)aGa>aTa	p.R19I	DOCK9_ENST00000339416.2_Intron			Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	0					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGCACAGTTTCTTTCAAAAAC	0.398													11	20					3.07112e-06	3.42433e-06	1	1	0	A	99667807	C	A	99667807	3	1	48	1	0	0	0	0	1	0	0	0	4721	928	32	2		2	DOCK9	13	99667807	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	540228	99667807	15502071	3126	7520										
TM9SF2	9375	broad.mit.edu	37	chr13	100188971	100188971	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacagataaaggccatgcaAaagatgcctgtgttattagt	9	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:100188971A>G	ENST00000376387.4	+	5	761	c.571A>G	c.(571-573)Aaa>Gaa	p.K191E	TM9SF2_ENST00000463709.1_3'UTR	NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	191					transport	endosome membrane|integral to plasma membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					AGGCCATGCAAAAGATGCCTG	0.363													17	23					0	0	1	0	0	G	100188971	A	G	100188971	3	3	48	1	0	0	0	0	1	0	0	0	16037	15	1	4	589	4	TM9SF2	13	100188971	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	521164	100188971	14980907	3127	7521										
CLYBL	171425	broad.mit.edu	37	chr13	100518526	100518526	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaaagaaaccctggatattCtctacgcccggcaaaagatt	8	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:100518526C>A	ENST00000376355.3	+	5	596	c.565C>A	c.(565-567)Ctc>Atc	p.L189I	CLYBL_ENST00000444838.2_Missense_Mutation_p.L189I|CLYBL_ENST00000339105.4_Missense_Mutation_p.L223I|CLYBL_ENST00000376360.1_Missense_Mutation_p.L223I|CLYBL_ENST00000376354.1_Missense_Mutation_p.L189I	NM_206808.2	NP_996531.1	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like	223					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding			NS(1)|kidney(6)|large_intestine(6)|lung(10)|skin(2)	25	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCTGGATATTCTCTACGCCCG	0.428													38	64					1.02591e-13	1.31916e-13	1	1	0	A	100518526	C	A	100518526	3	1	48	1	0	0	0	0	1	0	0	0	3596	913	32	2	689	2	CLYBL	13	100518526	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	329555	100518526	14651352	3128	7522										
ZIC5	85416	broad.mit.edu	37	chr13	100617759	100617759	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcctggcaaacgtaccactCattgaggttggtcacctgag	12	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:100617759C>A	ENST00000267294.4	-	2	2097	c.1864G>T	c.(1864-1866)Gag>Tag	p.E622*		NM_033132.3	NP_149123.2	Q96T25	ZIC5_HUMAN	Zic family member 5	622					cell differentiation	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|lung(2)|prostate(1)|skin(2)	9	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACGTACCACTCATTGAGGTTG	0.607													37	59					3.21399e-22	4.46229e-22	1	1	0	A	100617759	C	A	100617759	4	1	48	1	0	0	0	0	0	1	0	0	17739	835	29	2	131	2	ZIC5	13	100617759	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	99233	100617759	14552119	3129	7523										
TMTC4	84899	broad.mit.edu	37	chr13	101258625	101258625	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttacccaaattaccatgGtaacttgcagcatttggatt	6	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:101258625G>T	ENST00000342624.5	-	18	2379	c.2121C>A	c.(2119-2121)taC>taA	p.Y707*	TMTC4_ENST00000328767.5_Nonsense_Mutation_p.Y577*|TMTC4_ENST00000376234.3_Nonsense_Mutation_p.Y688*	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	688						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AATTACCATGGTAACTTGCAG	0.313													12	17					0.00010058	0.000108553	1	1	0	T	101258625	G	T	101258625	4	4	48	1	0	0	0	0	0	1	0	0	16322	1256	44	5	169	5	TMTC4	13	101258625	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	640866	101258625	13911253	3130	7524										
FGF14	2259	broad.mit.edu	37	chr13	102378997	102378997	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagaaaatgagctgctggtTtggttttctttactctgttc	10	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:102378997T>G	ENST00000376131.4	-	4	682	c.587A>C	c.(586-588)aAa>aCa	p.K196T	FGF14_ENST00000376143.4_Missense_Mutation_p.K191T	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	191					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGCTGCTGGTTTGGTTTTCTT	0.358													26	37					0	0	1	0	0	G	102378997	T	G	102378997	3	3	48	1	0	0	0	0	1	0	0	0	5875	1841	64	4	179	4	FGF14	13	102378997	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1120372	102378997	12790881	3131	7525										
FGF14	2259	broad.mit.edu	37	chr13	102379130	102379130	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataattttcaaaaacagattCtttaaacttgcattcagggg	6	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:102379130C>A	ENST00000376131.4	-	4	549	c.454G>T	c.(454-456)Gaa>Taa	p.E152*	FGF14_ENST00000376143.4_Nonsense_Mutation_p.E147*	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	147					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding	p.E147*(1)|p.E152*(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAAACAGATTCTTTAAACTTG	0.358													3	19					0.184627	0.185817	1	1	0	A	102379130	C	A	102379130	4	1	48	1	0	0	0	0	0	1	0	0	5875	922	32	2	312	2	FGF14	13	102379130	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	133	102379130	12790748	3132	7526										
TPP2	7174	broad.mit.edu	37	chr13	103299592	103299592	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaactccaagctgcccactActttgtgaactattatatga	6	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:103299592A>G	ENST00000376052.3	+	21	2542	c.2526A>G	c.(2524-2526)ctA>ctG	p.L842L	TPP2_ENST00000376065.4_Silent_p.L842L			P29144	TPP2_HUMAN	tripeptidyl peptidase II	842					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCTGCCCACTACTTTGTGAAC	0.358													8	22					0	0	1	0	0	G	103299592	A	G	103299592	2	3	48	1	0	0	0	0	0	0	0	1	16472	378	14	4		4	TPP2	13	103299592	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	920462	103299592	11870286	3133	7527										
LIG4	3981	broad.mit.edu	37	chr13	108862660	108862660	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagatttgtatatctgctttGaatgcattatgaatgaatgg	9	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:108862660G>T	ENST00000356922.4	-	2	1229	c.957C>A	c.(955-957)ttC>ttA	p.F319L	LIG4_ENST00000405925.1_Missense_Mutation_p.F319L|LIG4_ENST00000442234.1_Missense_Mutation_p.F319L	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	319					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TATCTGCTTTGAATGCATTAT	0.333								Non-homologous end-joining					22	41					0.000229342	0.00024587	1	1	0	T	108862660	G	T	108862660	3	4	48	1	0	0	0	0	1	0	0	0	8822	1281	45	2	1782	2	LIG4	13	108862660	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5563068	108862660	6307218	3134	7528										
TNFSF13B	10673	broad.mit.edu	37	chr13	108922412	108922412	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaccttgctgctggcactgCtgtcttgctgcctcacggtg	11	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:108922412C>T	ENST00000375887.4	+	1	347	c.169C>T	c.(169-171)Ctg>Ttg	p.L57L	TNFSF13B_ENST00000542136.1_Silent_p.L57L|TNFSF13B_ENST00000430559.1_Silent_p.L57L	NM_006573.4	NP_006564.1	Q9Y275	TN13B_HUMAN	tumor necrosis factor (ligand) superfamily, member 13b	57					cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding			large_intestine(1)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			GCTGGCACTGCTGTCTTGCTG	0.622													30	147					0	0	1	0	0	T	108922412	C	T	108922412	2	4	48	1	0	0	0	0	0	0	0	1	16365	796	28	3		3	TNFSF13B	13	108922412	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	59752	108922412	6247466	3135	7529										
MYO16	23026	broad.mit.edu	37	chr13	109707398	109707399	+	Frame_Shift_Ins	INS	-	-	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctttttattacagttattINSaaaaaagaaaggaacttcta							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:109707398_109707399insA	ENST00000356711.2	+	26	3113_3114	c.2987_2988insA	c.(2986-2988)taafs	p.*996fs	MYO16_ENST00000357550.2_Frame_Shift_Ins_p.*996fs|MYO16_ENST00000457511.2_Frame_Shift_Ins_p.*508fs	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	996	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTACAGTTATTAAAAAAGAAAG	0.396													8	19	---	---	---	---						A	109707399	-	A	109707398	7	5	48	1	0	1	1	0	0	0	0	0	10111	1764	61	0	3085	0	MYO16	13	109707398	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	784986	109707398	5462480	3136	7530										
COL4A1	1282	broad.mit.edu	37	chr13	110829261	110829261	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttggtctcctttctggcccTtcatgctgcccatgtccacc	7	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:110829261T>G	ENST00000375820.4	-	34	2961	c.2840A>C	c.(2839-2841)aAg>aCg	p.K947T		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	947	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TTTCTGGCCCTTCATGCTGCC	0.577													16	57					0	0	1	0	0	G	110829261	T	G	110829261	3	3	48	1	0	0	0	0	1	0	0	0	3712	1609	56	4	2245	4	COL4A1	13	110829261	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1121863	110829261	4340617	3137	7531										
PROZ	8858	broad.mit.edu	37	chr13	113824786	113824786	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgttataatacgggaaaaTtttgtactgacaacagcaaa	9	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:113824786T>G	ENST00000342783.4	+	8	706	c.699T>G	c.(697-699)aaT>aaG	p.N233K	PROZ_ENST00000493630.1_3'UTR|PROZ_ENST00000375547.2_Missense_Mutation_p.N211K	NM_001256134.1	NP_001243063.1	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma glycoprotein	211	Peptidase S1.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity			NS(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(2)|skin(2)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	TACGGGAAAATTTTGTACTGA	0.299													14	27					0	0	1	0	0	G	113824786	T	G	113824786	3	3	48	1	0	0	0	0	1	0	0	0	12613	1490	52	4	659	4	PROZ	13	113824786	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2995525	113824786	1345092	3138	7532										
CDC16	8881	broad.mit.edu	37	chr13	115030682	115030682	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatgcttggtcattgcatcGaaatgtacattggtgattct	9	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr13:115030682G>A	ENST00000360383.3	+	17	1768	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	CDC16_ENST00000375310.1_Missense_Mutation_p.E430K|CDC16_ENST00000375308.1_Missense_Mutation_p.E430K|CDC16_ENST00000356221.3_Missense_Mutation_p.E524K|CDC16_ENST00000375312.3_Missense_Mutation_p.E379K|CDC16_ENST00000252458.6_Missense_Mutation_p.E379K|CDC16_ENST00000461716.1_3'UTR|CDC16_ENST00000252457.5_Missense_Mutation_p.E523K	NM_001078645.1|NM_003903.3	NP_001072113.1|NP_003894.3	Q13042	CDC16_HUMAN	cell division cycle 16	524					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding	p.E523K(1)		endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			TCATTGCATCGAAATGTACAT	0.333													35	64					0	0	1	0	0	A	115030682	G	A	115030682	3	1	48	1	0	0	0	0	1	0	0	0	3080	1059	37	1	1636	1	CDC16	13	115030682	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1205896	115030682	139196	3139	7533										
POTEG	404785	broad.mit.edu	37	chr14	19553564	19553564	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggcacttctggagaccacGacgattctgctatgaagaca	11	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:19553564G>A	ENST00000409832.3	+	1	200	c.148G>A	c.(148-150)Gac>Aac	p.D50N		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	50										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						TGGAGACCACGACGATTCTGC	0.607													88	603					0	0	1	0	0	A	19553564	G	A	19553564	3	1	48	1	0	0	0	0	1	0	0	0	12312	1058	37	1	150	1	POTEG	14	19553564	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		19553564	87795976	3140	7534										
OR4N2	390429	broad.mit.edu	37	chr14	20295871	20295871	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggtggacttcctctctgcGaagaagataatctcctacag	9	10	2	2	rs144051874	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20295871G>A	ENST00000568211.1	+	1	264	c.264G>A	c.(262-264)gcG>gcA	p.A88A	OR4N2_ENST00000315947.1_Silent_p.A88A			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCCTCTCTGCGAAGAAGATAA	0.517													56	289					0	0	1	0	0	A	20295871	G	A	20295871	2	1	48	1	0	0	0	0	0	0	0	1	11124	1045	37	1		1	OR4N2	14	20295871	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	742307	20295871	87053669	3141	7535										
OR4K17	390436	broad.mit.edu	37	chr14	20585842	20585842	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatactcccatgtattttCtccttggtaatctctctttt	4	10	3	1	rs143610275	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20585842C>T	ENST00000315543.4	+	1	277	c.277C>T	c.(277-279)Ctc>Ttc	p.L93F		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CATGTATTTTCTCCTTGGTAA	0.393													7	210					0	0	1	0	0	T	20585842	C	T	20585842	3	4	48	1	0	0	0	0	1	0	0	0	11118	913	32	3	279	3	OR4K17	14	20585842	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	289971	20585842	86763698	3142	7536										
OR11H6	122748	broad.mit.edu	37	chr14	20692492	20692492	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtttgcactggcctgcatCtctgctccttccactgagct	8	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20692492C>A	ENST00000315519.2	+	1	702	c.624C>A	c.(622-624)atC>atA	p.I208I		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TGGCCTGCATCTCTGCTCCTT	0.498													12	24					2.27111e-07	2.60515e-07	1	1	0	A	20692492	C	A	20692492	2	1	48	1	0	0	0	0	0	0	0	1	10976	903	32	2		2	OR11H6	14	20692492	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	106650	20692492	86657048	3143	7537										
OR11H6	122748	broad.mit.edu	37	chr14	20692796	20692796	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaatccccttatctatagtCttcgaaacaaagacatgaaa	4	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20692796C>A	ENST00000315519.2	+	1	1006	c.928C>A	c.(928-930)Ctt>Att	p.L310I		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TATCTATAGTCTTCGAAACAA	0.418													40	75					5.73237e-09	6.82905e-09	1	1	0	A	20692796	C	A	20692796	3	1	48	1	0	0	0	0	1	0	0	0	10976	913	32	2	930	2	OR11H6	14	20692796	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	304	20692796	86656744	3144	7538										
TTC5	91875	broad.mit.edu	37	chr14	20760161	20760161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctttcctttgtgctgaattCggtgaagccgcaggttgggc	13	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20760161C>T	ENST00000258821.3	-	9	1240	c.1184G>A	c.(1183-1185)cGa>cAa	p.R395Q		NM_138376.2	NP_612385.2	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	395					DNA repair	cytoplasm|nucleus	binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		GTGCTGAATTCGGTGAAGCCG	0.448													19	33					0	0	1	0	0	T	20760161	C	T	20760161	3	4	48	1	0	0	0	0	1	0	0	0	16772	884	31	1	146	1	TTC5	14	20760161	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67365	20760161	86589379	3145	7539										
TTC5	91875	broad.mit.edu	37	chr14	20763928	20763928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagttgttgctctcgttgcCggggctctggccaggcaggg	17	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20763928C>T	ENST00000258821.3	-	7	838	c.782G>A	c.(781-783)cGg>cAg	p.R261Q		NM_138376.2	NP_612385.2	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	261					DNA repair	cytoplasm|nucleus	binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CTCTCGTTGCCGGGGCTCTGG	0.493													46	69					0	0	1	0	0	T	20763928	C	T	20763928	3	4	48	1	0	0	0	0	1	0	0	0	16772	652	23	1	556	1	TTC5	14	20763928	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3767	20763928	86585612	3146	7540										
PARP2	10038	broad.mit.edu	37	chr14	20825862	20825862	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgaatccagatggttataCcctcaactacaatgaatata	5	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20825862C>G	ENST00000250416.5	+	16	1685	c.1658C>G	c.(1657-1659)aCc>aGc	p.T553S	PARP2_ENST00000527915.1_3'UTR|PARP2_ENST00000429687.3_Missense_Mutation_p.T540S	NM_001042618.1|NM_005484.3	NP_001036083.1|NP_005475.2	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase 2	553	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	15	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		GATGGTTATACCCTCAACTAC	0.413								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					17	54					0	0	1	0	0	G	20825862	C	G	20825862	3	3	48	1	0	0	0	0	1	0	0	0	11507	507	18	5	1720	5	PARP2	14	20825862	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	61934	20825862	86523678	3147	7541										
TEP1	7011	broad.mit.edu	37	chr14	20872882	20872882	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcagcaatggccaagatgTtattggccacattccggacg	11	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20872882T>G	ENST00000262715.5	-	5	960	c.920A>C	c.(919-921)aAc>aCc	p.N307T	TEP1_ENST00000556935.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	307	TROVE.		N -> K (in dbSNP:rs1760898).		telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCCAAGATGTTATTGGCCAC	0.552													19	64					0	0	1	0	0	G	20872882	T	G	20872882	3	3	48	1	0	0	0	0	1	0	0	0	15817	1725	60	4	7167	4	TEP1	14	20872882	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	47020	20872882	86476658	3148	7542										
APEX1	328	broad.mit.edu	37	chr14	20925288	20925288	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgctgggatgaagcctttcGcaagttcctgaagggcctgg	15	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20925288G>A	ENST00000216714.3	+	5	846	c.578G>A	c.(577-579)cGc>cAc	p.R193H	APEX1_ENST00000557054.1_Missense_Mutation_p.A12T|APEX1_ENST00000555414.1_Missense_Mutation_p.R193H|APEX1_ENST00000398030.4_Missense_Mutation_p.R193H|APEX1_ENST00000557365.1_3'UTR	NM_001244249.1|NM_001641.3	NP_001231178.1|NP_001632.2	P27695	APEX1_HUMAN	APEX nuclease (multifunctional DNA repair enzyme) 1	193					base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity	p.R193H(1)		breast(2)|endometrium(1)|large_intestine(4)|ovary(2)	9	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	GAAGCCTTTCGCAAGTTCCTG	0.542								Other BER factors					18	29					0	0	1	0	0	A	20925288	G	A	20925288	3	1	48	1	0	0	0	0	1	0	0	0	765	1087	38	1	592	1	APEX1	14	20925288	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	52406	20925288	86424252	3149	7543										
RNASE10	338879	broad.mit.edu	37	chr14	20979224	20979224	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctaacttctgttataaaAaagcacattattataacctg	3	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:20979224A>C	ENST00000430083.1	+	2	1082	c.678A>C	c.(676-678)aaA>aaC	p.K226N	RNASE10_ENST00000328444.5_Missense_Mutation_p.K198N			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	198						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		CTGTTATAAAAAAGCACATTA	0.413													15	19					0	0	1	0	0	C	20979224	A	C	20979224	3	2	48	1	0	0	0	0	1	0	0	0	13451	11	1	4	596	4	RNASE10	14	20979224	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	53936	20979224	86370316	3150	7544										
RPGRIP1	57096	broad.mit.edu	37	chr14	21793213	21793213	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtggagaaagtccatggCttggccacactgattggtaa	12	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:21793213C>T	ENST00000206660.6	+	14	2199	c.2199C>T	c.(2197-2199)ggC>ggT	p.G733G	RPGRIP1_ENST00000557771.1_Silent_p.G695G|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000307974.4_Silent_p.G92G|RPGRIP1_ENST00000400017.2_Silent_p.G733G|RPGRIP1_ENST00000553500.1_Intron|RPGRIP1_ENST00000382933.4_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	733					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AAGTCCATGGCTTGGCCACAC	0.512													32	75					0	0	1	0	0	T	21793213	C	T	21793213	2	4	48	1	0	0	0	0	0	0	0	1	13600	784	28	3		3	RPGRIP1	14	21793213	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	813989	21793213	85556327	3151	7545										
RPGRIP1	57096	broad.mit.edu	37	chr14	21795831	21795831	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacccaacggatctattcaAgtgcaactggattggaagtt	9	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:21795831A>C	ENST00000206660.6	+	17	2760	c.2760A>C	c.(2758-2760)caA>caC	p.Q920H	RPGRIP1_ENST00000557771.1_Missense_Mutation_p.Q882H|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.Q577H|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.Q279H|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.Q920H|RPGRIP1_ENST00000382933.4_Missense_Mutation_p.Q246H			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	920					response to stimulus|visual perception	cilium		p.Q920H(1)|p.Q536H(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GATCTATTCAAGTGCAACTGG	0.428													27	34					0	0	1	0	0	C	21795831	A	C	21795831	3	2	48	1	0	0	0	0	1	0	0	0	13600	69	3	4	2826	4	RPGRIP1	14	21795831	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2618	21795831	85553709	3152	7546										
SUPT16H	11198	broad.mit.edu	37	chr14	21828672	21828672	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatatccactttgtctcctcGaacagatgtgaagcggaagc	9	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:21828672G>A	ENST00000216297.2	-	18	2415	c.2077C>T	c.(2077-2079)Cga>Tga	p.R693*		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	693					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TTGTCTCCTCGAACAGATGTG	0.408													20	46					0	0	1	0	0	A	21828672	G	A	21828672	4	1	48	1	0	0	0	0	0	1	0	0	15451	1066	37	1	1102	1	SUPT16H	14	21828672	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	32841	21828672	85520868	3153	7547										
CHD8	57680	broad.mit.edu	37	chr14	21859710	21859710	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggggcatcctcacccaccAgcaaagtaccatccacctta	7	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:21859710A>C	ENST00000399982.2	-	35	7041	c.6977T>G	c.(6976-6978)cTg>cGg	p.L2326R	CHD8_ENST00000557364.1_Missense_Mutation_p.L2326R|CHD8_ENST00000430710.3_Missense_Mutation_p.L2047R	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2326					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CTCACCCACCAGCAAAGTACC	0.552													12	28					0	0	1	0	0	C	21859710	A	C	21859710	3	2	48	1	0	0	0	0	1	0	0	0	3353	188	7	4	780	4	CHD8	14	21859710	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	31038	21859710	85489830	3154	7548										
CHD8	57680	broad.mit.edu	37	chr14	21870219	21870219	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacaaaacttggagccttcaTcatcttcctccatgatggct	6	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:21870219T>C	ENST00000399982.2	-	19	4023	c.3959A>G	c.(3958-3960)gAt>gGt	p.D1320G	CHD8_ENST00000555962.1_5'UTR|CHD8_ENST00000557364.1_Missense_Mutation_p.D1320G|CHD8_ENST00000430710.3_Missense_Mutation_p.D1041G	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1320					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GGAGCCTTCATCATCTTCCTC	0.393													33	43					0	0	1	0	0	C	21870219	T	C	21870219	3	2	48	1	0	0	0	0	1	0	0	0	3353	1435	50	4	3862	4	CHD8	14	21870219	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	10509	21870219	85479321	3155	7549										
CHD8	57680	broad.mit.edu	37	chr14	21870647	21870647	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgctctgcccaattcgatGacatcgtgcctgggcctggt	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:21870647G>T	ENST00000399982.2	-	18	3794	c.3730C>A	c.(3730-3732)Cat>Aat	p.H1244N	CHD8_ENST00000555962.1_5'UTR|CHD8_ENST00000557364.1_Missense_Mutation_p.H1244N|CHD8_ENST00000430710.3_Missense_Mutation_p.H965N	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1244	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CCAATTCGATGACATCGTGCC	0.418													9	23					0.00448238	0.00465112	1	1	0	T	21870647	G	T	21870647	3	4	48	1	0	0	0	0	1	0	0	0	3353	1290	45	2	4095	2	CHD8	14	21870647	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	428	21870647	85478893	3156	7550										
SLC7A7	9056	broad.mit.edu	37	chr14	23242890	23242890	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccatttctgcagcaactgAcatacacaggacctggaggt	9	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:23242890A>G	ENST00000397532.3	-	10	1990	c.1465T>C	c.(1465-1467)Tca>Cca	p.S489P	SLC7A7_ENST00000397528.4_Missense_Mutation_p.S489P|SLC7A7_ENST00000554061.1_5'UTR|SLC7A7_ENST00000555702.1_Missense_Mutation_p.S489P|SLC7A7_ENST00000397529.2_Missense_Mutation_p.S489P|SLC7A7_ENST00000285850.7_Missense_Mutation_p.S489P|SLC7A7_ENST00000554517.1_Missense_Mutation_p.S223P			Q9UM01	YLAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	489			S -> P (in LPI).		blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		GCAGCAACTGACATACACAGG	0.478													19	35					0	0	1	0	0	G	23242890	A	G	23242890	3	3	48	1	0	0	0	0	1	0	0	0	14757	275	10	4	74	4	SLC7A7	14	23242890	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1372243	23242890	84106650	3157	7551										
CMTM5	0	broad.mit.edu	37	chr14	23847687	23847687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagtactaccagcgcttcGaccgaattaactggccctgt	8	15	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:23847687G>A	ENST00000359320.3	+	2	700	c.256G>A	c.(256-258)Gac>Aac	p.D86N	CMTM5_ENST00000339180.4_Missense_Mutation_p.D86N|CMTM5_ENST00000397227.3_Intron|CMTM5_ENST00000342473.4_Intron|CMTM5_ENST00000382809.2_Missense_Mutation_p.D86N|CMTM5_ENST00000555731.1_Missense_Mutation_p.D48N	NM_138460.2	NP_612469.1	Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	86	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CCAGCGCTTCGACCGAATTAA	0.567													64	104					0	0	1	0	0	A	23847687	G	A	23847687	3	1	48	1	0	0	0	0	1	0	0	0	3609	1058	37	1	262	1	CMTM5	14	23847687	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	604797	23847687	83501853	3158	7552										
MYH6	4624	broad.mit.edu	37	chr14	23874928	23874928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccatgtcctcaatcttgtCgaacttgggtgggttctgct	12	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:23874928C>T	ENST00000405093.3	-	4	323	c.253G>A	c.(253-255)Gac>Aac	p.D85N	MYH6_ENST00000356287.3_Missense_Mutation_p.D85N	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	85	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCAATCTTGTCGAACTTGGGT	0.582													33	74					0	0	1	0	0	T	23874928	C	T	23874928	3	4	48	1	0	0	0	0	1	0	0	0	10085	884	31	1	5710	1	MYH6	14	23874928	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	27241	23874928	83474612	3159	7553										
MYH7	4625	broad.mit.edu	37	chr14	23902789	23902789	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgccaccctctcgagacacGatcttggccttgacaaactc	7	15	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:23902789G>A	ENST00000355349.3	-	3	315	c.153C>T	c.(151-153)atC>atT	p.I51I		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	51	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTCGAGACACGATCTTGGCCT	0.557													25	47					0	0	1	0	0	A	23902789	G	A	23902789	2	1	48	1	0	0	0	0	0	0	0	1	10086	1048	37	1		1	MYH7	14	23902789	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	27861	23902789	83446751	3160	7554										
JPH4	84502	broad.mit.edu	37	chr14	24040637	24040637	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatccaggggctccgtgtCggaaccttctgagtcctgcc	11	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:24040637C>T	ENST00000397118.3	-	6	2205	c.1303G>A	c.(1303-1305)Gac>Aac	p.D435N	JPH4_ENST00000544177.1_Missense_Mutation_p.D100N|JPH4_ENST00000356300.4_Missense_Mutation_p.D435N	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	435					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GGCTCCGTGTCGGAACCTTCT	0.617													19	42					0	0	1	0	0	T	24040637	C	T	24040637	3	4	48	1	0	0	0	0	1	0	0	0	8006	884	31	1	591	1	JPH4	14	24040637	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	137848	24040637	83308903	3161	7555										
LRRC16B	90668	broad.mit.edu	37	chr14	24533552	24533552	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagggtcctggaggaaagttCtaggtgtgatgcctaaacac	13	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:24533552C>A	ENST00000342740.5	+	32	3231	c.3077C>A	c.(3076-3078)tCt>tAt	p.S1026Y	LRRC16B_ENST00000334420.7_Missense_Mutation_p.S122Y	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1026										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GAGGAAAGTTCTAGGTGTGAT	0.582													3	9					0.000602214	0.000636035	1	1	0	A	24533552	C	A	24533552	3	1	48	1	0	0	0	0	1	0	0	0	9016	913	32	2	3203	2	LRRC16B	14	24533552	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	492915	24533552	82815988	3162	7556										
RIPK3	11035	broad.mit.edu	37	chr14	24808484	24808484	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctaggcgcagcacgaattCgttatccagacttgccatgg	10	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:24808484C>A	ENST00000216274.5	-	3	426	c.208G>T	c.(208-210)Gaa>Taa	p.E70*	RIPK3_ENST00000554338.1_5'UTR	NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	70	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		AGCACGAATTCGTTATCCAGA	0.562													37	63					1.47244e-24	2.06782e-24	1	1	0	A	24808484	C	A	24808484	4	1	48	1	0	0	0	0	0	1	0	0	13433	893	31	2	1380	2	RIPK3	14	24808484	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	274932	24808484	82541056	3163	7557										
NFATC4	4776	broad.mit.edu	37	chr14	24836377	24836377	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcctctccaagcctgacttTcccggaaactccagtccagg	9	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:24836377T>A	ENST00000413692.2	+	1	261	c.117T>A	c.(115-117)ttT>ttA	p.F39L	NFATC4_ENST00000440487.2_3'UTR|NFATC4_ENST00000554591.1_Missense_Mutation_p.F39L	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0					cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		AGCCTGACTTTCCCGGAAACT	0.627													13	40					0	0	1	0	0	A	24836377	T	A	24836377	3	1	48	1	0	0	0	0	1	0	0	0	10411	1780	62	4	119	4	NFATC4	14	24836377	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	27893	24836377	82513163	3164	7558										
CMA1	1215	broad.mit.edu	37	chr14	24975706	24975706	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatatcgtggtgaagagtaGaagtgttatattttggatga	13	1	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:24975706G>T	ENST00000250378.3	-	3	343	c.314C>A	c.(313-315)tCt>tAt	p.S105Y	CMA1_ENST00000206446.4_5'UTR|RP11-80A15.1_ENST00000555109.1_Intron	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell	105	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		GTGAAGAGTAGAAGTGTTATA	0.433													44	73					6.68952e-21	9.19686e-21	1	1	0	T	24975706	G	T	24975706	3	4	48	1	0	0	0	0	1	0	0	0	3597	942	33	2	441	2	CMA1	14	24975706	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	139329	24975706	82373834	3165	7559										
GZMB	3002	broad.mit.edu	37	chr14	25101296	25101296	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagcctgaggggctgcacaGctctggtccgcttggccttt	14	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:25101296G>T	ENST00000216341.4	-	4	474	c.368C>A	c.(367-369)gCt>gAt	p.A123D	GZMB_ENST00000382542.1_Missense_Mutation_p.A157D|RP11-104E19.1_ENST00000557736.1_RNA|GZMB_ENST00000382540.1_Missense_Mutation_p.A78D|GZMB_ENST00000415355.3_Missense_Mutation_p.A111D|RP11-104E19.1_ENST00000555300.1_RNA|GZMB_ENST00000526004.1_Missense_Mutation_p.L78M			P10144	GRAB_HUMAN	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	123	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(4)|stomach(4)|urinary_tract(2)	13				GBM - Glioblastoma multiforme(265;0.028)		GGGCTGCACAGCTCTGGTCCG	0.637													12	46					1.08611e-07	1.25818e-07	1	1	0	T	25101296	G	T	25101296	3	4	48	1	0	0	0	0	1	0	0	0	6956	971	34	5	383	5	GZMB	14	25101296	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	125590	25101296	82248244	3166	7560										
G2E3	55632	broad.mit.edu	37	chr14	31077225	31077225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggaccagaaaatacccagCcaattttagatgatgtttca	7	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:31077225C>T	ENST00000206595.6	+	12	1604	c.1450C>T	c.(1450-1452)Cca>Tca	p.P484S	G2E3_ENST00000553504.1_Missense_Mutation_p.P514S|G2E3_ENST00000438909.2_Missense_Mutation_p.P438S	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	484	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						AAATACCCAGCCAATTTTAGA	0.363													4	64					0	0	1	0	0	T	31077225	C	T	31077225	3	4	48	1	0	0	0	0	1	0	0	0	6174	739	26	3	1492	3	G2E3	14	31077225	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5975929	31077225	76272315	3167	7561										
COCH	1690	broad.mit.edu	37	chr14	31354209	31354209	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgtggcagaaagaatgaGtagcactaccgttgactctg	12	7	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:31354209G>A	ENST00000382493.4	+	3	348	c.248G>A	c.(247-249)aGt>aAt	p.S83N	COCH_ENST00000216361.4_Intron|RP11-829H16.3_ENST00000555421.1_RNA|COCH_ENST00000396618.3_Intron|COCH_ENST00000460581.2_Intron|RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000475087.1_Intron			O43405	COCH_HUMAN	cochlin	244	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		GAAAGAATGAGTAGCACTACC	0.383													39	69					0	0	1	0	0	A	31354209	G	A	31354209	3	1	48	1	0	0	0	0	1	0	0	0	3679	1044	36	3		3	COCH	14	31354209	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	276984	31354209	75995331	3168	7562										
HECTD1	25831	broad.mit.edu	37	chr14	31585633	31585633	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaggtgacggagtacattcGacttcttccaagagctctga	11	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:31585633G>A	ENST00000399332.1	-	30	5915	c.5427C>T	c.(5425-5427)gtC>gtT	p.V1809V	HECTD1_ENST00000553700.1_Silent_p.V1809V	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1809					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GAGTACATTCGACTTCTTCCA	0.418													22	31					0	0	1	0	0	A	31585633	G	A	31585633	2	1	48	1	0	0	0	0	0	0	0	1	7079	1045	37	1		1	HECTD1	14	31585633	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	231424	31585633	75763907	3169	7563										
HECTD1	25831	broad.mit.edu	37	chr14	31614112	31614112	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgctttcaacagctttaaaAtggtcatcgtataaatctcg	6	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:31614112A>C	ENST00000399332.1	-	16	3020	c.2532T>G	c.(2530-2532)caT>caG	p.H844Q	HECTD1_ENST00000553700.1_Missense_Mutation_p.H844Q	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	844					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CAGCTTTAAAATGGTCATCGT	0.343													15	18					0	0	1	0	0	C	31614112	A	C	31614112	3	2	48	1	0	0	0	0	1	0	0	0	7079	98	4	4	5412	4	HECTD1	14	31614112	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	28479	31614112	75735428	3170	7564										
HECTD1	25831	broad.mit.edu	37	chr14	31637631	31637631	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttcatctttgtttgtatCtttctttttcttatcatctc	2	9	8	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:31637631C>A	ENST00000399332.1	-	10	1983	c.1495G>T	c.(1495-1497)Gat>Tat	p.D499Y	HECTD1_ENST00000553700.1_Missense_Mutation_p.D499Y	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	499					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTGTTTGTATCTTTCTTTTTC	0.328													44	65					5.20006e-24	7.2863e-24	1	1	0	A	31637631	C	A	31637631	3	1	48	1	0	0	0	0	1	0	0	0	7079	913	32	2	6473	2	HECTD1	14	31637631	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23519	31637631	75711909	3171	7565										
HEATR5A	25938	broad.mit.edu	37	chr14	31828138	31828138	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggtcagtctcttgtaggaAaggacttagtatcaaaagat	10	5	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:31828138A>C	ENST00000543095.2	-	15	2381	c.2197T>G	c.(2197-2199)Ttc>Gtc	p.F733V	HEATR5A_ENST00000439348.1_Missense_Mutation_p.F727V|HEATR5A_ENST00000439727.1_Missense_Mutation_p.F440V|HEATR5A_ENST00000389961.3_Missense_Mutation_p.F727V|HEATR5A_ENST00000404677.3_Missense_Mutation_p.F733V	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	727							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TCTTGTAGGAAAGGACTTAGT	0.393													15	33					0	0	1	0	0	C	31828138	A	C	31828138	3	2	48	1	0	0	0	0	1	0	0	0	7071	14	1	4	4031	4	HEATR5A	14	31828138	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	190507	31828138	75521402	3172	7566										
NUBPL	80224	broad.mit.edu	37	chr14	32315743	32315743	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaaacacaaaactcatattTttggtgctgatggtgcaagg	10	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:32315743T>G	ENST00000281081.7	+	9	805	c.760T>G	c.(760-762)Ttt>Gtt	p.F254V	NUBPL_ENST00000418681.2_3'UTR|NUBPL_ENST00000536705.1_Missense_Mutation_p.F158V	NM_001201573.1|NM_001201574.1|NM_025152.2	NP_001188502.1|NP_001188503.1|NP_079428.2	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	254					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding			endometrium(1)|lung(2)|prostate(1)|skin(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		AACTCATATTTTTGGTGCTGA	0.383													9	12					0	0	1	0	0	G	32315743	T	G	32315743	3	3	48	1	0	0	0	0	1	0	0	0	10764	1841	64	4	794	4	NUBPL	14	32315743	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	487605	32315743	75033797	3173	7567										
ARHGAP5	394	broad.mit.edu	37	chr14	32560867	32560867	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaacttaaacaggaacataTaagaaaaaggagagaagagt	9	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:32560867T>C	ENST00000345122.3	+	2	1307	c.992T>C	c.(991-993)aTa>aCa	p.I331T	ARHGAP5_ENST00000539826.2_Missense_Mutation_p.I331T|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.I331T|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.I331T|ARHGAP5_ENST00000433497.1_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	331					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CAGGAACATATAAGAAAAAGG	0.313													23	37					0	0	1	0	0	C	32560867	T	C	32560867	3	2	48	1	0	0	0	0	1	0	0	0	883	1406	49	4	994	4	ARHGAP5	14	32560867	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	245124	32560867	74788673	3174	7568										
ARHGAP5	394	broad.mit.edu	37	chr14	32561892	32561892	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcattgagttttattgggGaatttattgggaaaataaga	11	1	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:32561892G>A	ENST00000345122.3	+	2	2332	c.2017G>A	c.(2017-2019)Gaa>Aaa	p.E673K	ARHGAP5_ENST00000539826.2_Missense_Mutation_p.E673K|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.E673K|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.E673K|ARHGAP5_ENST00000433497.1_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	673					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTTTATTGGGGAATTTATTGG	0.358													21	50					0	0	1	0	0	A	32561892	G	A	32561892	3	1	48	1	0	0	0	0	1	0	0	0	883	1175	41	3	2019	3	ARHGAP5	14	32561892	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1025	32561892	74787648	3175	7569										
AKAP6	9472	broad.mit.edu	37	chr14	33290942	33290942	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgccatttctgaaaaacaAtccaaaggtcactggcatga	7	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:33290942A>G	ENST00000280979.4	+	13	4093	c.3923A>G	c.(3922-3924)aAt>aGt	p.N1308S	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1308					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTGAAAAACAATCCAAAGGTC	0.408													10	28					0	0	1	0	0	G	33290942	A	G	33290942	3	3	48	1	0	0	0	0	1	0	0	0	452	101	4	4	3969	4	AKAP6	14	33290942	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	729050	33290942	74058598	3176	7570										
AKAP6	9472	broad.mit.edu	37	chr14	33292587	33292587	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggctctgtaaaacgtgtCtctgaaaataatggaaatgg	10	5	2	1	rs149001001		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:33292587C>A	ENST00000280979.4	+	13	5738	c.5568C>A	c.(5566-5568)gtC>gtA	p.V1856V	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1856					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TAAAACGTGTCTCTGAAAATA	0.353													28	40					2.14196e-07	2.46404e-07	1	1	0	A	33292587	C	A	33292587	2	1	48	1	0	0	0	0	0	0	0	1	452	900	32	2		2	AKAP6	14	33292587	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1645	33292587	74056953	3177	7571										
NPAS3	64067	broad.mit.edu	37	chr14	34269487	34269487	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctcagaacccatcaatttCgacaatgacagcagcatctg	6	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:34269487C>T	ENST00000346562.2	+	11	1952	c.1878C>T	c.(1876-1878)ttC>ttT	p.F626F	NPAS3_ENST00000551492.1_Silent_p.F663F|NPAS3_ENST00000357798.5_Silent_p.F645F|NPAS3_ENST00000356141.4_Silent_p.F658F|NPAS3_ENST00000548645.1_Silent_p.F628F	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	658					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CCATCAATTTCGACAATGACA	0.617													17	56					0	0	1	0	0	T	34269487	C	T	34269487	2	4	48	1	0	0	0	0	0	0	0	1	10610	883	31	1		1	NPAS3	14	34269487	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	976900	34269487	73080053	3178	7572										
NPAS3	64067	broad.mit.edu	37	chr14	34270072	34270072	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacgcgcacgctgttaacttCgtggacgttaacagccccgg	11	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:34270072C>T	ENST00000346562.2	+	11	2537	c.2463C>T	c.(2461-2463)ttC>ttT	p.F821F	NPAS3_ENST00000551492.1_Silent_p.F858F|NPAS3_ENST00000357798.5_Silent_p.F840F|NPAS3_ENST00000356141.4_Silent_p.F853F|NPAS3_ENST00000548645.1_Silent_p.F823F	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	853					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CTGTTAACTTCGTGGACGTTA	0.647													11	9					0	0	1	0	0	T	34270072	C	T	34270072	2	4	48	1	0	0	0	0	0	0	0	1	10610	883	31	1		1	NPAS3	14	34270072	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	585	34270072	73079468	3179	7573										
RALGAPA1	253959	broad.mit.edu	37	chr14	36096694	36096694	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttacggttatatcttctaaGcattcattagatgtcggagg	9	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:36096694G>A	ENST00000258840.6	-	34	5472	c.5082C>T	c.(5080-5082)tgC>tgT	p.C1694C	RALGAPA1_ENST00000307138.6_Silent_p.C1647C|RALGAPA1_ENST00000382366.3_Silent_p.C1660C|RALGAPA1_ENST00000389698.3_Silent_p.C1647C			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1647	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TATCTTCTAAGCATTCATTAG	0.403													24	43					0	0	1	0	0	A	36096694	G	A	36096694	2	1	48	1	0	0	0	0	0	0	0	1	13064	963	34	3		3	RALGAPA1	14	36096694	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1826622	36096694	71252846	3180	7574										
RALGAPA1	253959	broad.mit.edu	37	chr14	36133883	36133883	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagacacagcaacatcagGaatgttgggatgaagagaag	13	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:36133883G>A	ENST00000258840.6	-	27	4306	c.3916C>T	c.(3916-3918)Cct>Tct	p.P1306S	RALGAPA1_ENST00000307138.6_Missense_Mutation_p.P1259S|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.P1272S|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.P1259S			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1259					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCAACATCAGGAATGTTGGGA	0.348													10	23					0	0	1	0	0	A	36133883	G	A	36133883	3	1	48	1	0	0	0	0	1	0	0	0	13064	1174	41	3	2548	3	RALGAPA1	14	36133883	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37189	36133883	71215657	3181	7575										
RALGAPA1	253959	broad.mit.edu	37	chr14	36155765	36155765	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccgaggcattaccacttcGaagtcgttctgctataaact	7	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:36155765G>A	ENST00000258840.6	-	19	3073	c.2683C>T	c.(2683-2685)Cga>Tga	p.R895*	RALGAPA1_ENST00000307138.6_Nonsense_Mutation_p.R848*|RALGAPA1_ENST00000382366.3_Nonsense_Mutation_p.R861*|RALGAPA1_ENST00000389698.3_Nonsense_Mutation_p.R848*			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	848					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TTACCACTTCGAAGTCGTTCT	0.368													11	10					0	0	1	0	0	A	36155765	G	A	36155765	4	1	48	1	0	0	0	0	0	1	0	0	13064	1066	37	1	3813	1	RALGAPA1	14	36155765	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	21882	36155765	71193775	3182	7576										
MIPOL1	145282	broad.mit.edu	37	chr14	37969124	37969124	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctcagtttacacaaatCtttatctcaagaagaaaatc	3	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:37969124C>A	ENST00000327441.7	+	13	1509	c.1043C>A	c.(1042-1044)tCt>tAt	p.S348Y	MIPOL1_ENST00000556451.1_Missense_Mutation_p.S317Y|MIPOL1_ENST00000545536.1_Missense_Mutation_p.S317Y|MIPOL1_ENST00000539062.2_Missense_Mutation_p.S317Y|MIPOL1_ENST00000537471.1_Missense_Mutation_p.S348Y|MIPOL1_ENST00000536774.1_Missense_Mutation_p.S167Y|MIPOL1_ENST00000396294.2_Missense_Mutation_p.S348Y	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	348										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		TTACACAAATCTTTATCTCAA	0.274													12	23					0.0809354	0.0819999	1	1	0	A	37969124	C	A	37969124	3	1	48	1	0	0	0	0	1	0	0	0	9640	913	32	2	1081	2	MIPOL1	14	37969124	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1813359	37969124	69380416	3183	7577										
SSTR1	0	broad.mit.edu	37	chr14	38678969	38678969	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgttgcgccactggcccttCggtgcgctgctctgccgcct	12	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:38678969C>T	ENST00000267377.2	+	3	992	c.375C>T	c.(373-375)ttC>ttT	p.F125F		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	125					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	ACTGGCCCTTCGGTGCGCTGC	0.597													74	172					0	0	1	0	0	T	38678969	C	T	38678969	2	4	48	1	0	0	0	0	0	0	0	1	15252	883	31	1		1	SSTR1	14	38678969	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	709845	38678969	68670571	3184	7578										
CLEC14A	161198	broad.mit.edu	37	chr14	38724396	38724396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggccgtccttccccagctCgaagcccgtagcacattcgc	10	18	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:38724396C>T	ENST00000342213.2	-	1	1178	c.832G>A	c.(832-834)Gag>Aag	p.E278K		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	278	EGF-like.					integral to membrane	sugar binding	p.E278Q(1)		breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TTCCCCAGCTCGAAGCCCGTA	0.672													46	90					0	0	1	0	0	T	38724396	C	T	38724396	3	4	48	1	0	0	0	0	1	0	0	0	3522	893	31	1	644	1	CLEC14A	14	38724396	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	45427	38724396	68625144	3185	7579										
TRAPPC6B	122553	broad.mit.edu	37	chr14	39639223	39639223	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtggcagcactcaccaccTccccctgctccgcggacttg	10	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:39639223T>C	ENST00000330149.5	-	1	303	c.77A>G	c.(76-78)gAg>gGg	p.E26G	TRAPPC6B_ENST00000557764.1_5'UTR|TRAPPC6B_ENST00000347691.5_Missense_Mutation_p.E26G	NM_001079537.1	NP_001073005.1	Q86SZ2	TPC6B_HUMAN	trafficking protein particle complex 6B	26					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0128)		ACTCACCACCTCCCCCTGCTC	0.547													7	38					0	0	1	0	0	C	39639223	T	C	39639223	3	2	48	1	0	0	0	0	1	0	0	0	16524	1551	54	4	423	4	TRAPPC6B	14	39639223	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	914827	39639223	67710317	3186	7580										
FSCB	84075	broad.mit.edu	37	chr14	44975624	44975624	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtgttcactagcaaaaatCtttcccgacgatttatgttt	8	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:44975624C>A	ENST00000340446.4	-	1	858	c.567G>T	c.(565-567)aaG>aaT	p.K189N		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	189						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		TAGCAAAAATCTTTCCCGACG	0.378													35	92					3.90053e-15	5.12206e-15	1	1	0	A	44975624	C	A	44975624	3	1	48	1	0	0	0	0	1	0	0	0	6100	912	32	2	1914	2	FSCB	14	44975624	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5336401	44975624	62373916	3187	7581										
FSCB	84075	broad.mit.edu	37	chr14	44975941	44975941	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctcaactaacttgacttCttttttctcttctacaatgg	3	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:44975941C>A	ENST00000340446.4	-	1	541	c.250G>T	c.(250-252)Gaa>Taa	p.E84*		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	84						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AACTTGACTTCTTTTTTCTCT	0.408													46	105					1.41504e-22	1.969e-22	1	1	0	A	44975941	C	A	44975941	4	1	48	1	0	0	0	0	0	1	0	0	6100	922	32	2	2231	2	FSCB	14	44975941	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	317	44975941	62373599	3188	7582										
FAM179B	23116	broad.mit.edu	37	chr14	45433195	45433195	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctcttgtagatagcaaacGcagggtacgccaagcagctt	11	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:45433195G>A	ENST00000361462.2	+	1	1754	c.1571G>A	c.(1570-1572)cGc>cAc	p.R524H	FAM179B_ENST00000382233.2_Missense_Mutation_p.R524H|FAM179B_ENST00000361577.3_Missense_Mutation_p.R524H|KLHL28_ENST00000553817.1_5'UTR			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	524							binding	p.R524H(1)		endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GATAGCAAACGCAGGGTACGC	0.463													31	72					0	0	1	0	0	A	45433195	G	A	45433195	3	1	48	1	0	0	0	0	1	0	0	0	5535	1087	38	1	1573	1	FAM179B	14	45433195	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	457254	45433195	61916345	3189	7583										
FAM179B	23116	broad.mit.edu	37	chr14	45535797	45535797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagagctgtaactgaagttCgtgaagtcaccagaaaatca	9	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:45535797C>T	ENST00000361462.2	+	17	4759	c.4576C>T	c.(4576-4578)Cgt>Tgt	p.R1526C	FAM179B_ENST00000382233.2_3'UTR|FAM179B_ENST00000361577.3_Missense_Mutation_p.R1473C			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1473							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						AACTGAAGTTCGTGAAGTCAC	0.323													16	31					0	0	1	0	0	T	45535797	C	T	45535797	3	4	48	1	0	0	0	0	1	0	0	0	5535	884	31	1	4479	1	FAM179B	14	45535797	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	102602	45535797	61813743	3190	7584										
FANCM	57697	broad.mit.edu	37	chr14	45624629	45624629	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagttaaagaaattagaaGaagttgtaattgaacacttc	7	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:45624629G>A	ENST00000267430.5	+	8	1448	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K	FANCM_ENST00000556036.1_Missense_Mutation_p.E455K|FANCM_ENST00000542564.2_Missense_Mutation_p.E429K	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	455	Helicase C-terminal.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GAAATTAGAAGAAGTTGTAAT	0.274								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				15	17					0	0	1	0	0	A	45624629	G	A	45624629	3	1	48	1	0	0	0	0	1	0	0	0	5703	943	33	3	1393	3	FANCM	14	45624629	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	88832	45624629	61724911	3191	7585										
FANCM	57697	broad.mit.edu	37	chr14	45633577	45633577	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaggtagtgaaacagtttCgtgacggtggttacaacacg	12	6	0	2	rs146151355		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:45633577C>T	ENST00000267430.5	+	10	1682	c.1597C>T	c.(1597-1599)Cgt>Tgt	p.R533C	FANCM_ENST00000556036.1_Missense_Mutation_p.R533C|FANCM_ENST00000542564.2_Missense_Mutation_p.R507C	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	533	Helicase C-terminal.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GAAACAGTTTCGTGACGGTGG	0.363								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				14	24					0	0	1	0	0	T	45633577	C	T	45633577	3	4	48	1	0	0	0	0	1	0	0	0	5703	884	31	1	1635	1	FANCM	14	45633577	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8948	45633577	61715963	3192	7586										
MDGA2	161357	broad.mit.edu	37	chr14	47530619	47530619	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgtgtaatgaccatccgcTcagaacttcttaatggacga	8	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:47530619T>G	ENST00000426342.1	-	7	1210	c.464A>C	c.(463-465)gAg>gCg	p.E155A	MDGA2_ENST00000399232.2_Missense_Mutation_p.E453A|MDGA2_ENST00000439988.2_Missense_Mutation_p.E384A|MDGA2_ENST00000357362.3_Missense_Mutation_p.E155A	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	384	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						GACCATCCGCTCAGAACTTCT	0.413													28	53					0	0	1	0	0	G	47530619	T	G	47530619	3	3	48	1	0	0	0	0	1	0	0	0	9456	1551	54	4	1763	4	MDGA2	14	47530619	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1897042	47530619	59818921	3193	7587										
POLE2	5427	broad.mit.edu	37	chr14	50118061	50118061	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatttactaagtcttcacGgaagacagtaatttcctgtg	7	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:50118061G>T	ENST00000539565.2	-	15	1386	c.1168C>A	c.(1168-1170)Cgt>Agt	p.R390S	POLE2_ENST00000216367.5_Missense_Mutation_p.R416S|POLE2_ENST00000554396.1_Missense_Mutation_p.R416S|POLE2_ENST00000556584.1_5'UTR	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	416					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					AAGTCTTCACGGAAGACAGTA	0.308													6	16					0.000157383	0.000169016	1	1	0	T	50118061	G	T	50118061	3	4	48	1	0	0	0	0	1	0	0	0	12244	1116	39	5	353	5	POLE2	14	50118061	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2587442	50118061	57231479	3194	7588										
KLHDC2	23588	broad.mit.edu	37	chr14	50244960	50244960	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgggaacttttgaattcGatgaaacatctttttgggta	9	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:50244960G>A	ENST00000298307.5	+	5	1393	c.532G>A	c.(532-534)Gat>Aat	p.D178N	KLHDC2_ENST00000553538.1_3'UTR|KLHDC2_ENST00000554589.1_Missense_Mutation_p.D178N|KLHDC2_ENST00000557247.1_Missense_Mutation_p.D178N	NM_014315.2	NP_055130.1	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	178						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(31;0.000959)|Breast(41;0.0117)					TTTTGAATTCGATGAAACATC	0.303													21	35					0	0	1	0	0	A	50244960	G	A	50244960	3	1	48	1	0	0	0	0	1	0	0	0	8398	1058	37	1	550	1	KLHDC2	14	50244960	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	126899	50244960	57104580	3195	7589										
ATL1	51062	broad.mit.edu	37	chr14	51057742	51057742	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgagcgagagaccacaggAattcagatatggagtgaaat	12	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:51057742A>C	ENST00000441560.2	+	4	847	c.366A>C	c.(364-366)ggA>ggC	p.G122G	ATL1_ENST00000357032.3_Silent_p.G122G|ATL1_ENST00000354525.4_Silent_p.G122G|ATL1_ENST00000358385.6_Silent_p.G122G	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	122					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						AGACCACAGGAATTCAGATAT	0.353													16	17					0	0	1	0	0	C	51057742	A	C	51057742	2	2	48	1	0	0	0	0	0	0	0	1	1105	233	9	4		4	ATL1	14	51057742	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	812782	51057742	56291798	3196	7590										
SAV1	60485	broad.mit.edu	37	chr14	51132015	51132015	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctttctctgaccatcaaaAaaattgtctgaataataata	4	8	3	2	rs147005969	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:51132015A>C	ENST00000324679.4	-	2	780	c.417T>G	c.(415-417)ttT>ttG	p.F139L		NM_021818.3	NP_068590.1	Q9H4B6	SAV1_HUMAN	salvador homolog 1 (Drosophila)	139					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					GACCATCAAAAAAATTGTCTG	0.393													28	29					0	0	1	0	0	C	51132015	A	C	51132015	3	2	48	1	0	0	0	0	1	0	0	0	13908	11	1	4	750	4	SAV1	14	51132015	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	74273	51132015	56217525	3197	7591										
NIN	51199	broad.mit.edu	37	chr14	51210967	51210967	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attacttctactaccttatcGacacagctatttaattcctc	2	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:51210967G>A	ENST00000245441.5	-	23	5371	c.5181C>T	c.(5179-5181)gtC>gtT	p.V1727V	NIN_ENST00000389868.3_Silent_p.V1014V|NIN_ENST00000324330.9_Silent_p.V1727V|NIN_ENST00000530997.2_Silent_p.V1727V|NIN_ENST00000382043.4_Silent_p.V1014V|NIN_ENST00000453196.1_Silent_p.V1727V|NIN_ENST00000382041.3_Silent_p.V1727V	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	1727					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CTACCTTATCGACACAGCTAT	0.408			T	PDGFRB	MPD								25	55					0	0	1	0	0	A	51210967	G	A	51210967	2	1	48	1	0	0	0	0	0	0	0	1	10463	1045	37	1		1	NIN	14	51210967	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	78952	51210967	56138573	3198	7592										
TXNDC16	57544	broad.mit.edu	37	chr14	52949572	52949572	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtactatgctgtcagaaGccatcactgttgcattaaat	8	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:52949572G>A	ENST00000281741.4	-	13	1591	c.1220C>T	c.(1219-1221)gCt>gTt	p.A407V	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	407	Thioredoxin.				cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					GCTGTCAGAAGCCATCACTGT	0.368													9	12					0	0	1	0	0	A	52949572	G	A	52949572	3	1	48	1	0	0	0	0	1	0	0	0	16856	971	34	3	1293	3	TXNDC16	14	52949572	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1738605	52949572	54399968	3199	7593										
STYX	6815	broad.mit.edu	37	chr14	53224469	53224469	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgtttttcaggaaaagttCttgtgcatggaaatgcaggg	12	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:53224469C>A	ENST00000354586.4	+	7	642	c.349C>A	c.(349-351)Ctt>Att	p.L117I	STYX_ENST00000442123.2_Missense_Mutation_p.L117I|STYX_ENST00000556861.1_Intron	NM_145251.3	NP_660294.1	Q8WUJ0	STYX_HUMAN	serine/threonine/tyrosine interacting protein	117	Tyrosine-protein phosphatase.				protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity	p.L117I(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(41;0.176)					AGGAAAAGTTCTTGTGCATGG	0.318													18	18					1.45105e-14	1.8931e-14	1	1	0	A	53224469	C	A	53224469	3	1	48	1	0	0	0	0	1	0	0	0	15415	913	32	2	375	2	STYX	14	53224469	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	274897	53224469	54125071	3200	7594										
DDHD1	0	broad.mit.edu	37	chr14	53619307	53619307	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttgtcctccttgtagaaCcagcgtacctcctccgggcc	8	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:53619307C>T	ENST00000357758.3	-	1	693	c.510G>A	c.(508-510)tgG>tgA	p.W170*	DDHD1_ENST00000323669.5_Nonsense_Mutation_p.W170*|DDHD1_ENST00000395606.1_Nonsense_Mutation_p.W170*	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	170					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					CCTTGTAGAACCAGCGTACCT	0.672													13	39					0	0	1	0	0	T	53619307	C	T	53619307	4	4	48	1	0	0	0	0	0	1	0	0	4349	508	18	3	2269	3	DDHD1	14	53619307	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	394838	53619307	53730233	3201	7595										
BMP4	652	broad.mit.edu	37	chr14	54418862	54418862	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcttccccgtctcaggtaTcaaactagcatggctcgcgc	8	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:54418862T>C	ENST00000245451.4	-	3	472	c.79A>G	c.(79-81)Ata>Gta	p.I27V	BMP4_ENST00000558984.1_Missense_Mutation_p.I27V|BMP4_ENST00000559087.1_Missense_Mutation_p.I27V|BMP4_ENST00000417573.1_Missense_Mutation_p.I27V	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	27					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						GTCTCAGGTATCAAACTAGCA	0.587													4	72					0	0	1	0	0	C	54418862	T	C	54418862	3	2	48	1	0	0	0	0	1	0	0	0	1461	1435	50	4	1155	4	BMP4	14	54418862	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	799555	54418862	52930678	3202	7596										
SAMD4A	23034	broad.mit.edu	37	chr14	55168871	55168871	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaagccaggaaacctcgaCgcgaaagtagaatatatgaa	10	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:55168871C>T	ENST00000251091.5	+	2	593	c.288C>T	c.(286-288)gaC>gaT	p.D96D	SAMD4A_ENST00000554335.1_Silent_p.D96D|SAMD4A_ENST00000555112.1_3'UTR|SAMD4A_ENST00000357634.3_Silent_p.D95D|SAMD4A_ENST00000392067.3_Silent_p.D96D	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	96					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						GAAACCTCGACGCGAAAGTAG	0.458													23	45					0	0	1	0	0	T	55168871	C	T	55168871	2	4	48	1	0	0	0	0	0	0	0	1	13872	535	19	1		1	SAMD4A	14	55168871	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	750009	55168871	52180669	3203	7597										
SAMD4A	23034	broad.mit.edu	37	chr14	55169170	55169170	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggcagaactctcgggattCtgggatttgcatcaatgcct	12	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:55169170C>A	ENST00000251091.5	+	2	892	c.587C>A	c.(586-588)tCt>tAt	p.S196Y	SAMD4A_ENST00000554335.1_Missense_Mutation_p.S196Y|SAMD4A_ENST00000555112.1_3'UTR|SAMD4A_ENST00000357634.3_Missense_Mutation_p.S195Y|SAMD4A_ENST00000392067.3_Missense_Mutation_p.S196Y	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	196					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						TCTCGGGATTCTGGGATTTGC	0.522													25	53					9.57634e-11	1.18295e-10	1	1	0	A	55169170	C	A	55169170	3	1	48	1	0	0	0	0	1	0	0	0	13872	913	32	2	590	2	SAMD4A	14	55169170	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	299	55169170	52180370	3204	7598										
DLGAP5	9787	broad.mit.edu	37	chr14	55625460	55625460	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacctgagacaacttttttCtgcaaagagaaactaacata	5	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:55625460C>T	ENST00000247191.2	-	14	1870		c.e14-1		DLGAP5_ENST00000395425.2_Splice_Site	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5						cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						CAACTTTTTTCTGCAAAGAGA	0.338													11	20					0	0	1	0	0	T	55625460	C	T	55625460	5	4	48	1	0	0	0	0	0	0	1	0	4591	927	32	3	1006	3	DLGAP5	14	55625460	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	456290	55625460	51724080	3205	7599										
DLGAP5	9787	broad.mit.edu	37	chr14	55629731	55629731	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatgattcatattattattGacttgccacccagattcctc	4	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:55629731G>T	ENST00000247191.2	-	13	1827	c.1611C>A	c.(1609-1611)gtC>gtA	p.V537V	DLGAP5_ENST00000395425.2_Silent_p.V537V	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	537					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						TATTATTATTGACTTGCCACC	0.294													11	17					5.50884e-06	6.10489e-06	1	1	0	T	55629731	G	T	55629731	2	4	48	1	0	0	0	0	0	0	0	1	4591	1277	45	2		2	DLGAP5	14	55629731	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4271	55629731	51719809	3206	7600										
KTN1	0	broad.mit.edu	37	chr14	56078943	56078943	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataaaaagaaagcagaaaaGaaaaagaataaaaagaaaga	8	1	0	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:56078943G>T	ENST00000416613.1	+	1	249	c.177G>T	c.(175-177)aaG>aaT	p.K59N	KTN1_ENST00000413890.2_Missense_Mutation_p.K59N|KTN1_ENST00000395311.1_Missense_Mutation_p.K59N|KTN1_ENST00000395314.3_Missense_Mutation_p.K59N|KTN1_ENST00000395309.3_Missense_Mutation_p.K59N|KTN1_ENST00000438792.2_Missense_Mutation_p.K59N|KTN1_ENST00000395308.1_Missense_Mutation_p.K59N			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	59					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						aagcagaaaagaaaaagaata	0.338			T	RET	papillary thryoid								12	29					3.07112e-06	3.42433e-06	1	1	0	T	56078943	G	T	56078943	3	4	48	1	0	0	0	0	1	0	0	0	8623	933	33	2	179	2	KTN1	14	56078943	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	449212	56078943	51270597	3207	7601										
KTN1	0	broad.mit.edu	37	chr14	56103931	56103931	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacagatttacagagtaaatTtgtggccaaagaaaatgaag	9	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:56103931T>G	ENST00000416613.1	+	10	1637	c.1565T>G	c.(1564-1566)tTt>tGt	p.F522C	KTN1_ENST00000413890.2_Missense_Mutation_p.F522C|KTN1_ENST00000395311.1_Missense_Mutation_p.F522C|KTN1_ENST00000395314.3_Missense_Mutation_p.F522C|KTN1_ENST00000395309.3_Missense_Mutation_p.F522C|KTN1_ENST00000438792.2_Missense_Mutation_p.F522C|KTN1_ENST00000395308.1_Missense_Mutation_p.F522C			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	522					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						CAGAGTAAATTTGTGGCCAAA	0.358			T	RET	papillary thryoid								25	28					0	0	1	0	0	G	56103931	T	G	56103931	3	3	48	1	0	0	0	0	1	0	0	0	8623	1841	64	4	1603	4	KTN1	14	56103931	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	24988	56103931	51245609	3208	7602										
NAA30	122830	broad.mit.edu	37	chr14	57876118	57876118	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgttttggaaaccgaaataAcaaataagtccgctttgaaa	7	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:57876118A>G	ENST00000556492.1	+	5	1127	c.973A>G	c.(973-975)Aca>Gca	p.T325A	NAA30_ENST00000554703.1_Missense_Mutation_p.N48S|NAA30_ENST00000555166.1_Missense_Mutation_p.T67A	NM_001011713.2	NP_001011713.2	Q147X3	NAA30_HUMAN	N(alpha)-acetyltransferase 30, NatC catalytic subunit	325	N-acetyltransferase.					cytoplasm	peptide alpha-N-acetyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|skin(2)	13						AACCGAAATAACAAATAAGTC	0.274													13	27					0	0	1	0	0	G	57876118	A	G	57876118	3	3	48	1	0	0	0	0	1	0	0	0	10169	43	2	4	987	4	NAA30	14	57876118	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1772187	57876118	49473422	3209	7603										
ACTR10	55860	broad.mit.edu	37	chr14	58697164	58697164	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagataatgaagagcaatCagttgccactttaatattgg	8	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:58697164C>A	ENST00000254286.4	+	11	916	c.836C>A	c.(835-837)tCa>tAa	p.S279*		NM_018477.2	NP_060947.1	Q9NZ32	ARP10_HUMAN	actin-related protein 10 homolog (S. cerevisiae)	279						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	13						GAAGAGCAATCAGTTGCCACT	0.289													4	59					0.150653	0.151842	1	1	0	A	58697164	C	A	58697164	4	1	48	1	0	0	0	0	0	1	0	0	208	838	29	2	878	2	ACTR10	14	58697164	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	821046	58697164	48652376	3210	7604										
ACTR10	55860	broad.mit.edu	37	chr14	58701269	58701269	+	Nonstop_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcattttccactgagaaataGaagtttgattaaaaatcaac	6	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:58701269G>T	ENST00000254286.4	+	13	1334	c.1254G>T	c.(1252-1254)taG>taT	p.*418Y	ACTR10_ENST00000554402.1_3'UTR	NM_018477.2	NP_060947.1	Q9NZ32	ARP10_HUMAN	actin-related protein 10 homolog (S. cerevisiae)	0						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	13						CTGAGAAATAGAAGTTTGATT	0.338													5	31					0.014758	0.015099	1	1	0	T	58701269	G	T	58701269	4	4	48	1	0	0	0	0	0	0	0	0	208	937	33	2	1304	2	ACTR10	14	58701269	Nonstop_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4105	58701269	48648271	3211	7605										
KIAA0586	9786	broad.mit.edu	37	chr14	58965566	58965566	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctaacagcggcagcagaGaacatcttaatgggacattc	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:58965566G>A	ENST00000423743.3	+	28	4182	c.3924G>A	c.(3922-3924)gaG>gaA	p.E1308E	KIAA0586_ENST00000261244.5_Silent_p.E1276E|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000354386.6_Silent_p.E1405E|KIAA0586_ENST00000556134.1_Silent_p.E1337E	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1276										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CGGCAGCAGAGAACATCTTAA	0.403													5	33					0	0	1	0	0	A	58965566	G	A	58965566	2	1	48	1	0	0	0	0	0	0	0	1	8227	933	33	3		3	KIAA0586	14	58965566	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	264297	58965566	48383974	3212	7606										
DAAM1	23002	broad.mit.edu	37	chr14	59792754	59792754	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacacatagtgaagcttaccCgcatttcatgtccatcctgc	7	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:59792754C>T	ENST00000395125.1	+	9	1156	c.1133C>T	c.(1132-1134)cCg>cTg	p.P378L	DAAM1_ENST00000360909.3_Missense_Mutation_p.P378L|DAAM1_ENST00000351081.1_Missense_Mutation_p.P378L	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	378	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		GAAGCTTACCCGCATTTCATG	0.443													7	50					0	0	1	0	0	T	59792754	C	T	59792754	3	4	48	1	0	0	0	0	1	0	0	0	4239	652	23	1	1167	1	DAAM1	14	59792754	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	827188	59792754	47556786	3213	7607										
DAAM1	23002	broad.mit.edu	37	chr14	59835509	59835509	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctaaattgaaacggaatCgcaaacgtattaccaaccag	6	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:59835509C>T	ENST00000395125.1	+	25	3192	c.3169C>T	c.(3169-3171)Cgc>Tgc	p.R1057C	DAAM1_ENST00000360909.3_Missense_Mutation_p.R1047C|DAAM1_ENST00000351081.1_Missense_Mutation_p.R1057C|DAAM1_ENST00000553966.1_3'UTR	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	1057	DAD.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding	p.R1057C(1)		breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		GAAACGGAATCGCAAACGTAT	0.368													19	33					0	0	1	0	0	T	59835509	C	T	59835509	3	4	48	1	0	0	0	0	1	0	0	0	4239	884	31	1	3267	1	DAAM1	14	59835509	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	42755	59835509	47514031	3214	7608										
SIX1	6495	broad.mit.edu	37	chr14	61115666	61115666	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccacagttgctgcagtttgGggtggttgtgaggcgagaac	17	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:61115666G>T	ENST00000247182.6	-	1	514	c.242C>A	c.(241-243)cCc>cAc	p.P81H	SIX1_ENST00000554986.1_Intron	NM_005982.3	NP_005973.1	Q15475	SIX1_HUMAN	SIX homeobox 1	81					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CTGCAGTTTGGGGTGGTTGTG	0.627													69	162					9.68594e-22	1.33983e-21	1	1	0	T	61115666	G	T	61115666	3	4	48	1	0	0	0	0	1	0	0	0	14400	1232	43	5	620	5	SIX1	14	61115666	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1280157	61115666	46233874	3215	7609										
MNAT1	4331	broad.mit.edu	37	chr14	61275130	61275130	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacaaagatgttattcagaAaaataaattaaagctggtcg	7	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:61275130A>G	ENST00000261245.4	+	4	505	c.404A>G	c.(403-405)aAa>aGa	p.K135R	MNAT1_ENST00000539616.2_Missense_Mutation_p.K135R	NM_002431.3	NP_002422.1	P51948	MAT1_HUMAN	MNAT CDK-activating kinase assembly factor 1	135					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			NS(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		GTTATTCAGAAAAATAAATTA	0.303								Direct reversal of damage;Direct reversal of damage;Nucleotide excision repair (NER)					7	8					0	0	1	0	0	G	61275130	A	G	61275130	3	3	48	1	0	0	0	0	1	0	0	0	9722	14	1	4	418	4	MNAT1	14	61275130	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	159464	61275130	46074410	3216	7610										
TRMT5	57570	broad.mit.edu	37	chr14	61444313	61444313	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaatattatttattttattTactgctgaggtgattcctgg	7	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:61444313T>C	ENST00000261249.6	-	3	1095	c.711A>G	c.(709-711)gtA>gtG	p.V237V	RP11-193F5.1_ENST00000553946.1_RNA	NM_020810.2	NP_065861.2	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	237						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(1)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		TTATTTTATTTACTGCTGAGG	0.313													14	23					0	0	1	0	0	C	61444313	T	C	61444313	2	2	48	1	0	0	0	0	0	0	0	1	16627	1741	61	4		4	TRMT5	14	61444313	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	169183	61444313	45905227	3217	7611										
SNAPC1	6617	broad.mit.edu	37	chr14	62249055	62249055	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcaagtcaaagcaactaggAaaaaagagaagaaagaaaga	11	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:62249055A>G	ENST00000216294.4	+	8	1020	c.916A>G	c.(916-918)Aaa>Gaa	p.K306E		NM_003082.3	NP_003073.1	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex, polypeptide 1, 43kDa	306					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		AGCAACTAGGAAAAAAGAGAA	0.388													16	26					0	0	1	0	0	G	62249055	A	G	62249055	3	3	48	1	0	0	0	0	1	0	0	0	14887	247	9	4	946	4	SNAPC1	14	62249055	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	804742	62249055	45100485	3218	7612										
WDR89	112840	broad.mit.edu	37	chr14	64066363	64066363	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtttttctctggctactcGagcatcccagcatttcacag	8	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:64066363G>A	ENST00000394942.2	-	2	386	c.298C>T	c.(298-300)Cga>Tga	p.R100*	WDR89_ENST00000267522.3_Nonsense_Mutation_p.R100*	NM_001008726.2|NM_001258272.1|NM_080666.3	NP_001008726.1|NP_001245201.1|NP_542397.1	Q96FK6	WDR89_HUMAN	WD repeat domain 89	100										endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		CTGGCTACTCGAGCATCCCAG	0.383													10	24					0	0	1	0	0	A	64066363	G	A	64066363	4	1	48	1	0	0	0	0	0	1	0	0	17395	1066	37	1	869	1	WDR89	14	64066363	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1817308	64066363	43283177	3219	7613										
WDR89	112840	broad.mit.edu	37	chr14	64066622	64066622	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcctaaggaacatttaacAatgtgcagattagcaaattg	8	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:64066622A>G	ENST00000394942.2	-	2	127	c.39T>C	c.(37-39)atT>atC	p.I13I	WDR89_ENST00000267522.3_Silent_p.I13I	NM_001008726.2|NM_001258272.1|NM_080666.3	NP_001008726.1|NP_001245201.1|NP_542397.1	Q96FK6	WDR89_HUMAN	WD repeat domain 89	13										endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		AACATTTAACAATGTGCAGAT	0.343													6	64					0	0	1	0	0	G	64066622	A	G	64066622	2	3	48	1	0	0	0	0	0	0	0	1	17395	126	5	4		4	WDR89	14	64066622	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	259	64066622	43282918	3220	7614										
SYNE2	23224	broad.mit.edu	37	chr14	64421617	64421617	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagaattaaaaatccccagAttgctggaaccagaaggtaa	8	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:64421617A>C	ENST00000358025.3	+	8	1001	c.771A>C	c.(769-771)agA>agC	p.R257S	SYNE2_ENST00000554584.1_Missense_Mutation_p.R257S|SYNE2_ENST00000341472.5_Missense_Mutation_p.R257S|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000356081.3_Missense_Mutation_p.R257S|SYNE2_ENST00000344113.4_Missense_Mutation_p.R257S	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	257	Actin-binding.|CH 2.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAATCCCCAGATTGCTGGAAC	0.353													8	34					0	0	1	0	0	C	64421617	A	C	64421617	3	2	48	1	0	0	0	0	1	0	0	0	15502	330	12	4	797	4	SYNE2	14	64421617	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	354995	64421617	42927923	3221	7615										
SYNE2	23224	broad.mit.edu	37	chr14	64430710	64430710	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaatgatacctactttaaaAagtataatgtaagtatgatt	6	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:64430710A>C	ENST00000358025.3	+	10	1212	c.982A>C	c.(982-984)Aag>Cag	p.K328Q	SYNE2_ENST00000554584.1_Missense_Mutation_p.K328Q|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.K328Q	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	328					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTACTTTAAAAAGTATAATGT	0.318													12	14					0	0	1	0	0	C	64430710	A	C	64430710	3	2	48	1	0	0	0	0	1	0	0	0	15502	15	1	4	1016	4	SYNE2	14	64430710	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	9093	64430710	42918830	3222	7616										
PLEKHG3	26030	broad.mit.edu	37	chr14	65197549	65197549	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgacggaatgcatgcgggAcaagcagcaggccaagttct	13	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:65197549A>G	ENST00000247226.7	+	4	739	c.431A>G	c.(430-432)gAc>gGc	p.D144G	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.D200G	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	200	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TGCATGCGGGACAAGCAGCAG	0.647													9	30					0	0	1	0	0	G	65197549	A	G	65197549	3	3	48	1	0	0	0	0	1	0	0	0	12117	275	10	4	441	4	PLEKHG3	14	65197549	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	766839	65197549	42151991	3223	7617										
PLEKHG3	26030	broad.mit.edu	37	chr14	65208583	65208583	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgggctcccggccgacttCgtgggccctgtttgagctcc	15	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:65208583C>T	ENST00000247226.7	+	14	2488	c.2180C>T	c.(2179-2181)tCg>tTg	p.S727L	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.S783L|PLEKHG3_ENST00000471182.2_Missense_Mutation_p.S316L|PLEKHG3_ENST00000492928.1_Intron|PLEKHG3_ENST00000484731.2_Missense_Mutation_p.S288L	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	783				YYENAEHHDAGFSV -> WWPHCTPASCSSPT (in Ref. 2; AAH04298).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CGGCCGACTTCGTGGGCCCTG	0.592													48	62					0	0	1	0	0	T	65208583	C	T	65208583	3	4	48	1	0	0	0	0	1	0	0	0	12117	893	31	1	2230	1	PLEKHG3	14	65208583	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11034	65208583	42140957	3224	7618										
MPP5	64398	broad.mit.edu	37	chr14	67745898	67745898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagataaccatgacaacatCccatatgaatgggcatgtta	7	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:67745898C>T	ENST00000261681.4	+	3	672	c.11C>T	c.(10-12)tCc>tTc	p.S4F	MPP5_ENST00000555925.1_Intron|MPP5_ENST00000556345.1_Missense_Mutation_p.S4F	NM_022474.3	NP_071919.2	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	4					tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	18				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		ATGACAACATCCCATATGAAT	0.368													9	23					0	0	1	0	0	T	67745898	C	T	67745898	3	4	48	1	0	0	0	0	1	0	0	0	9785	855	30	3	13	3	MPP5	14	67745898	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2537315	67745898	39603642	3225	7619										
EIF2S1	1965	broad.mit.edu	37	chr14	67847476	67847476	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccacaggctgtcaaaattCgagcaggtaaatgatttttt	8	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:67847476C>T	ENST00000256383.4	+	5	1035	c.574C>T	c.(574-576)Cga>Tga	p.R192*	EIF2S1_ENST00000466499.2_Nonsense_Mutation_p.R192*	NM_004094.4	NP_004085.1	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	192						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		TGTCAAAATTCGAGCAGGTAA	0.318													12	28					0	0	1	0	0	T	67847476	C	T	67847476	4	4	48	1	0	0	0	0	0	1	0	0	5035	876	31	1	588	1	EIF2S1	14	67847476	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	101578	67847476	39502064	3226	7620										
DCAF5	8816	broad.mit.edu	37	chr14	69588977	69588977	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccactgttgaaagccaggcaAaaaatgttggaatggtgctc	11	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:69588977A>C	ENST00000341516.5	-	2	462	c.315T>G	c.(313-315)ttT>ttG	p.F105L	DCAF5_ENST00000554215.1_Missense_Mutation_p.F23L|DCAF5_ENST00000556847.1_Missense_Mutation_p.F23L|DCAF5_ENST00000557386.1_Missense_Mutation_p.F105L|DCAF5_ENST00000389997.6_Missense_Mutation_p.F105L	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	105						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						AAGCCAGGCAAAAAATGTTGG	0.488													33	57					0	0	1	0	0	C	69588977	A	C	69588977	3	2	48	1	0	0	0	0	1	0	0	0	4297	11	1	4	2545	4	DCAF5	14	69588977	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1741501	69588977	37760563	3227	7621										
EXD2	0	broad.mit.edu	37	chr14	69695675	69695675	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attggatattttggcagatgGcaccattttgaaagttggag	12	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:69695675G>A	ENST00000409014.1	+	5	758	c.101G>A	c.(100-102)gGc>gAc	p.G34D	EXD2_ENST00000409242.1_Missense_Mutation_p.G34D|EXD2_ENST00000492815.1_3'UTR|EXD2_ENST00000409949.1_Missense_Mutation_p.G34D|EXD2_ENST00000409675.1_Missense_Mutation_p.G34D|EXD2_ENST00000409018.3_Missense_Mutation_p.G159D|EXD2_ENST00000312994.5_Missense_Mutation_p.G159D|EXD2_ENST00000449989.1_Missense_Mutation_p.G34D	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	34	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						TTGGCAGATGGCACCATTTTG	0.507													34	56					0	0	1	0	0	A	69695675	G	A	69695675	3	1	48	1	0	0	0	0	1	0	0	0	5325	1203	42	3	103	3	EXD2	14	69695675	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	106698	69695675	37653865	3228	7622										
SLC39A9	55334	broad.mit.edu	37	chr14	69866118	69866118	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctccattagcctgctgtCtctggctatgttggtgggat	11	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:69866118C>T	ENST00000031146.4	+	1	710	c.32C>T	c.(31-33)tCt>tTt	p.S11F	SLC39A9_ENST00000557046.1_Missense_Mutation_p.S11F|SLC39A9_ENST00000556605.1_Missense_Mutation_p.S11F|SLC39A9_ENST00000555245.1_Intron|SLC39A9_ENST00000336643.5_Missense_Mutation_p.S11F			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	11					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		AGCCTGCTGTCTCTGGCTATG	0.438													5	15					0	0	1	0	0	T	69866118	C	T	69866118	3	4	48	1	0	0	0	0	1	0	0	0	14679	913	32	3	34	3	SLC39A9	14	69866118	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	170443	69866118	37483422	3229	7623										
SLC8A3	6547	broad.mit.edu	37	chr14	70633726	70633726	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatcctcctcaaaaatgtCgtcatcaattatgcccacgg	5	13	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:70633726C>T	ENST00000381269.2	-	2	2167	c.1414G>A	c.(1414-1416)Gac>Aac	p.D472N	SLC8A3_ENST00000528359.1_Missense_Mutation_p.D472N|SLC8A3_ENST00000534137.1_Missense_Mutation_p.D472N|SLC8A3_ENST00000357887.3_Missense_Mutation_p.D472N|SLC8A3_ENST00000356921.2_Missense_Mutation_p.D472N	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	472	Calx-beta 1.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCAAAAATGTCGTCATCAATT	0.512													60	124					0	0	1	0	0	T	70633726	C	T	70633726	3	4	48	1	0	0	0	0	1	0	0	0	14762	884	31	1	1508	1	SLC8A3	14	70633726	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	767608	70633726	36715814	3230	7624										
ADAM21	8747	broad.mit.edu	37	chr14	70924467	70924467	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcaagaagctcttagtttCtagacacctcccagtgttca	8	11	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:70924467C>A	ENST00000603540.1	+	2	509	c.251C>A	c.(250-252)tCt>tAt	p.S84Y	ADAM21_ENST00000267499.3_Missense_Mutation_p.S84Y|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	84					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CTCTTAGTTTCTAGACACCTC	0.512													13	122					1.67942e-08	1.98515e-08	1	1	0	A	70924467	C	A	70924467	3	1	48	1	0	0	0	0	1	0	0	0	242	913	32	2	253	2	ADAM21	14	70924467	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	290741	70924467	36425073	3231	7625										
MAP3K9	4293	broad.mit.edu	37	chr14	71205013	71205013	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagcgtccctggcccccacGtccgtcccttcttctttggg	9	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:71205013G>A	ENST00000554752.2	-	8	1792	c.1793C>T	c.(1792-1794)aCg>aTg	p.T598M	MAP3K9_ENST00000381250.4_Missense_Mutation_p.T598M|MAP3K9_ENST00000554146.1_Missense_Mutation_p.T335M|MAP3K9_ENST00000553414.1_Missense_Mutation_p.T340M|MAP3K9_ENST00000555993.2_Missense_Mutation_p.T598M			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	598					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TGGCCCCCACGTCCGTCCCTT	0.557													29	57					0	0	1	0	0	A	71205013	G	A	71205013	3	1	48	1	0	0	0	0	1	0	0	0	9306	1145	40	1	1587	1	MAP3K9	14	71205013	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	280546	71205013	36144527	3232	7626										
MAP3K9	4293	broad.mit.edu	37	chr14	71216702	71216702	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagaaggaataggaagggcGagtttgttcatggccactcc	14	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:71216702G>A	ENST00000554752.2	-	4	1097	c.1098C>T	c.(1096-1098)ctC>ctT	p.L366L	MAP3K9_ENST00000381250.4_Silent_p.L366L|MAP3K9_ENST00000554146.1_Silent_p.L103L|MAP3K9_ENST00000553414.1_Silent_p.L60L|MAP3K9_ENST00000555993.2_Silent_p.L366L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	366	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TAGGAAGGGCGAGTTTGTTCA	0.507													4	93					0	0	1	0	0	A	71216702	G	A	71216702	2	1	48	1	0	0	0	0	0	0	0	1	9306	1045	37	1		1	MAP3K9	14	71216702	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11689	71216702	36132838	3233	7627										
PCNX	22990	broad.mit.edu	37	chr14	71478246	71478246	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatccagttctacctcagttCgattttatccacatgatgtg	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:71478246C>T	ENST00000304743.2	+	10	3204	c.2758C>T	c.(2758-2760)Cga>Tga	p.R920*	PCNX_ENST00000439984.3_Nonsense_Mutation_p.R814*|PCNX_ENST00000238570.5_Nonsense_Mutation_p.R920*	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	920						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TACCTCAGTTCGATTTTATCC	0.269													4	23					0	0	1	0	0	T	71478246	C	T	71478246	4	4	48	1	0	0	0	0	0	1	0	0	11637	876	31	1	2796	1	PCNX	14	71478246	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	261544	71478246	35871294	3234	7628										
DPF3	8110	broad.mit.edu	37	chr14	73138003	73138003	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctccgtggtacgtgctgcGgccgctgcctccttctcctt	10	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:73138003G>A	ENST00000541685.1	-	9	927	c.915C>T	c.(913-915)gcC>gcT	p.A305A	DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Intron|DPF3_ENST00000546183.1_Silent_p.A315A	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	134					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TACGTGCTGCGGCCGCTGCCT	0.498													31	43					0	0	1	0	0	A	73138003	G	A	73138003	2	1	48	1	0	0	0	0	0	0	0	1	4745	1103	39	1		1	DPF3	14	73138003	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1659757	73138003	34211537	3235	7629										
PNMA1	9240	broad.mit.edu	37	chr14	74179915	74179915	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaataacattatccaaaataTagtttagcatctctgctggc	6	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:74179915T>C	ENST00000316836.3	-	1	1213	c.428A>G	c.(427-429)tAt>tGt	p.Y143C		NM_006029.4	NP_006020.4	Q8ND90	PNMA1_HUMAN	paraneoplastic Ma antigen 1	143					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|urinary_tract(2)	13				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		atccaaaatatagtttagcat	0.532													54	72					0	0	1	0	0	C	74179915	T	C	74179915	3	2	48	1	0	0	0	0	1	0	0	0	12200	1406	49	4	637	4	PNMA1	14	74179915	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1041912	74179915	33169625	3236	7630										
ZNF410	57862	broad.mit.edu	37	chr14	74363124	74363124	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggagaggagacgagagctcAgactgtacagaaatccccgg	14	10	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:74363124A>G	ENST00000555044.1	+	4	469	c.275A>G	c.(274-276)cAg>cGg	p.Q92R	ZNF410_ENST00000540593.1_Intron|ZNF410_ENST00000324593.6_Missense_Mutation_p.Q92R|ZNF410_ENST00000442160.3_Missense_Mutation_p.Q109R|ZNF410_ENST00000556797.1_Missense_Mutation_p.Q39R|RP5-1021I20.5_ENST00000554009.1_RNA|ZNF410_ENST00000412490.3_3'UTR|ZNF410_ENST00000334521.4_Missense_Mutation_p.Q39R	NM_001242928.1|NM_021188.2	NP_001229857.1|NP_067011.1	Q86VK4	ZN410_HUMAN	zinc finger protein 410	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(234;0.00369)		ACGAGAGCTCAGACTGTACAG	0.463													33	58					0	0	1	0	0	G	74363124	A	G	74363124	3	3	48	1	0	0	0	0	1	0	0	0	17946	188	7	4	285	4	ZNF410	14	74363124	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	183209	74363124	32986416	3237	7631										
ALDH6A1	4329	broad.mit.edu	37	chr14	74539002	74539002	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaaaagcacgtttgcaggaAgcaatggctgcatccatttc	11	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:74539002A>C	ENST00000553458.1	-	4	350	c.252T>G	c.(250-252)gcT>gcG	p.A84A	AC005484.5_ENST00000492026.1_RNA|ALDH6A1_ENST00000350259.4_Silent_p.A84A|CCDC176_ENST00000553773.1_Intron|ALDH6A1_ENST00000556852.1_5'UTR	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	84						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	GTTTGCAGGAAGCAATGGCTG	0.483													26	44					0	0	1	0	0	C	74539002	A	C	74539002	2	2	48	1	0	0	0	0	0	0	0	1	500	59	3	4		4	ALDH6A1	14	74539002	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	175878	74539002	32810538	3238	7632										
MLH3	27030	broad.mit.edu	37	chr14	75506691	75506691	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaactgctaagctctcagCctggccactgcttacatcaa	6	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:75506691C>T	ENST00000355774.2	-	5	3708	c.3493G>A	c.(3493-3495)Gct>Act	p.A1165T	MLH3_ENST00000238662.7_Missense_Mutation_p.A1165T|MLH3_ENST00000544985.1_Intron|MLH3_ENST00000380968.2_Missense_Mutation_p.A111T|MLH3_ENST00000555671.1_5'UTR|MLH3_ENST00000556740.1_Missense_Mutation_p.A1165T|MLH3_ENST00000556257.1_Intron	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	1165					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		AAGCTCTCAGCCTGGCCACTG	0.338								Mismatch excision repair (MMR)					20	24					0	0	1	0	0	T	75506691	C	T	75506691	3	4	48	1	0	0	0	0	1	0	0	0	9665	739	26	3	904	3	MLH3	14	75506691	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	967689	75506691	31842849	3239	7633										
MLH3	27030	broad.mit.edu	37	chr14	75515305	75515305	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgataattccacaaataattTttcttgctttaaaaacattt	2	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:75515305T>G	ENST00000355774.2	-	2	1269	c.1054A>C	c.(1054-1056)Aaa>Caa	p.K352Q	MLH3_ENST00000238662.7_Missense_Mutation_p.K352Q|MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000556740.1_Missense_Mutation_p.K352Q|MLH3_ENST00000556257.1_Missense_Mutation_p.K352Q	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	352					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		ACAAATAATTTTTCTTGCTTT	0.363								Mismatch excision repair (MMR)					18	19					0	0	1	0	0	G	75515305	T	G	75515305	3	3	48	1	0	0	0	0	1	0	0	0	9665	1850	64	4	3355	4	MLH3	14	75515305	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	8614	75515305	31834235	3240	7634										
KIAA1737	85457	broad.mit.edu	37	chr14	77580149	77580149	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgaggactcagctctgcagGgtgtgccctctctggtggca	14	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:77580149G>A	ENST00000361786.2	+	4	1005	c.688G>A	c.(688-690)Ggt>Agt	p.G230S	RP11-463C8.4_ENST00000557752.1_Intron	NM_033426.2	NP_219494.2	Q9C0C6	K1737_HUMAN	KIAA1737	230										endometrium(2)|lung(4)|prostate(3)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		AGCTCTGCAGGGTGTGCCCTC	0.617													23	47					0	0	1	0	0	A	77580149	G	A	77580149	3	1	48	1	0	0	0	0	1	0	0	0	8296	1232	43	3	698	3	KIAA1737	14	77580149	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2064844	77580149	29769391	3241	7635										
ZDHHC22	283576	broad.mit.edu	37	chr14	77605688	77605688	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggcaggccagggaggtgtAgaggcagaacaggacgaagt	19	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:77605688A>G	ENST00000319374.4	-	2	596	c.394T>C	c.(394-396)Tac>Cac	p.Y132H	RP11-463C8.4_ENST00000557752.1_Intron	NM_174976.2	NP_777636.2	Q8N966	ZDH22_HUMAN	zinc finger, DHHC-type containing 22	132						integral to membrane	acyltransferase activity|zinc ion binding			kidney(1)|lung(1)|urinary_tract(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		AGGGAGGTGTAGAGGCAGAAC	0.607													8	5					0	0	1	0	0	G	77605688	A	G	77605688	3	3	48	1	0	0	0	0	1	0	0	0	17670	420	15	4	405	4	ZDHHC22	14	77605688	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	25539	77605688	29743852	3242	7636										
NGB	58157	broad.mit.edu	37	chr14	77737225	77737225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtgccgtgctccagcgggCtgcggctcactgcccgccag	15	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:77737225C>T	ENST00000298352.4	-	1	430	c.56G>A	c.(55-57)aGc>aAc	p.S19N		NM_021257.3	NP_067080.1	Q9NPG2	NGB_HUMAN	neuroglobin	19	Globin.					hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0273)		CTCCAGCGGGCTGCGGCTCAC	0.746													5	9					0	0	1	0	0	T	77737225	C	T	77737225	3	4	48	1	0	0	0	0	1	0	0	0	10438	797	28	3	415	3	NGB	14	77737225	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	131537	77737225	29612315	3243	7637										
AHSA1	10598	broad.mit.edu	37	chr14	77935522	77935522	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgaggaagagcggacgcGacagggctggcagcggtact	17	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:77935522G>A	ENST00000216479.3	+	9	1107	c.947G>A	c.(946-948)cGa>cAa	p.R316Q	AHSA1_ENST00000555457.1_3'UTR	NM_012111.2	NP_036243.1	O95433	AHSA1_HUMAN	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	316					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding			endometrium(1)|kidney(3)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)	8			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		GAGCGGACGCGACAGGGCTGG	0.577													10	191					0	0	1	0	0	A	77935522	G	A	77935522	3	1	48	1	0	0	0	0	1	0	0	0	415	1058	37	1	981	1	AHSA1	14	77935522	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	198297	77935522	29414018	3244	7638										
ADCK1	57143	broad.mit.edu	37	chr14	78398005	78398005	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctgggcacccgcgccagcGccagctcctttctcaacatg	9	19	1	0	rs141847250	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:78398005G>A	ENST00000238561.5	+	10	1450	c.1351G>A	c.(1351-1353)Gcc>Acc	p.A451T	ADCK1_ENST00000556560.1_3'UTR|ADCK1_ENST00000341211.5_Missense_Mutation_p.A383T	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	458	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		CCGCGCCAGCGCCAGCTCCTT	0.647													14	32					0	0	1	0	0	A	78398005	G	A	78398005	3	1	48	1	0	0	0	0	1	0	0	0	287	1087	38	1	1385	1	ADCK1	14	78398005	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	462483	78398005	28951535	3245	7639										
TSHR	7253	broad.mit.edu	37	chr14	81422098	81422098	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgggcggaatggggtgttCgtctccaccctgcgagtgcc	15	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:81422098C>T	ENST00000541158.2	+	2	396	c.74C>T	c.(73-75)tCg>tTg	p.S25L	TSHR_ENST00000557096.1_3'UTR|TSHR_ENST00000298171.2_Missense_Mutation_p.S25L|TSHR_ENST00000342443.6_Missense_Mutation_p.S25L|TSHR_ENST00000554435.1_Missense_Mutation_p.S25L|TSHR_ENST00000554263.1_Missense_Mutation_p.S25L			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	25					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	ATGGGGTGTTCGTCTCCACCC	0.607			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						75	119					0	0	1	0	0	T	81422098	C	T	81422098	3	4	48	1	0	0	0	0	1	0	0	0	16682	893	31	1	76	1	TSHR	14	81422098	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3024093	81422098	25927442	3246	7640										
TSHR	7253	broad.mit.edu	37	chr14	81610603	81610603	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgaggcagggtctccacaAcatggaagatgtctatgaac	12	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:81610603A>G	ENST00000541158.2	+	11	2523	c.2201A>G	c.(2200-2202)aAc>aGc	p.N734S	TSHR_ENST00000298171.2_Missense_Mutation_p.N734S|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	734					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GGTCTCCACAACATGGAAGAT	0.473			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						37	59					0	0	1	0	0	G	81610603	A	G	81610603	3	3	48	1	0	0	0	0	1	0	0	0	16682	43	2	4	2376	4	TSHR	14	81610603	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	188505	81610603	25738937	3247	7641										
GALC	2581	broad.mit.edu	37	chr14	88407879	88407879	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggggtctctatgtatacaTcacactttatagtcagattg	8	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:88407879T>C	ENST00000261304.2	-	15	1800	c.1694A>G	c.(1693-1695)gAt>gGt	p.D565G	GALC_ENST00000393568.4_Missense_Mutation_p.D542G|GALC_ENST00000393569.2_Missense_Mutation_p.D539G|GALC_ENST00000544807.2_Missense_Mutation_p.D509G	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	565					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TATGTATACATCACACTTTAT	0.373													48	67					0	0	1	0	0	C	88407879	T	C	88407879	3	2	48	1	0	0	0	0	1	0	0	0	6240	1435	50	4	375	4	GALC	14	88407879	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	6797276	88407879	18941661	3248	7642										
KCNK10	54207	broad.mit.edu	37	chr14	88789139	88789139	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcgtctcgattggaaattTcattgcttcgttgcccagaa	10	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:88789139T>G	ENST00000319231.5	-	1	454	c.4A>C	c.(4-6)Aaa>Caa	p.K2Q	KCNK10_ENST00000340700.5_Intron	NM_138317.2	NP_612190.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	0					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						attggaaatttcattgcttcg	0.473													15	52					0	0	1	0	0	G	88789139	T	G	88789139	3	3	48	1	0	0	0	0	1	0	0	0	8102	1792	62	4	1711	4	KCNK10	14	88789139	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	381260	88789139	18560401	3249	7643										
SPATA7	55812	broad.mit.edu	37	chr14	88892857	88892857	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtttcagttagtcatttcGaaagcacccagtggggatct	11	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:88892857G>A	ENST00000556553.1	+	6	1117	c.558G>A	c.(556-558)tcG>tcA	p.S186S	SPATA7_ENST00000045347.7_Silent_p.S218S|SPATA7_ENST00000393545.4_Silent_p.S218S|SPATA7_ENST00000356583.5_Silent_p.S186S			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	218					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						TAGTCATTTCGAAAGCACCCA	0.468													27	51					0	0	1	0	0	A	88892857	G	A	88892857	2	1	48	1	0	0	0	0	0	0	0	1	15069	1045	37	1		1	SPATA7	14	88892857	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	103718	88892857	18456683	3250	7644										
EML5	161436	broad.mit.edu	37	chr14	89131693	89131693	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatcttaccaggtgaaaatcGaatatctgaaatcatatctt	6	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:89131693G>A	ENST00000554922.1	-	22	3513	c.3265C>T	c.(3265-3267)Cga>Tga	p.R1089*	EML5_ENST00000380664.5_Nonsense_Mutation_p.R1089*|EML5_ENST00000352093.5_Nonsense_Mutation_p.R1051*	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1089						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GGTGAAAATCGAATATCTGAA	0.343													8	8					0	0	1	0	0	A	89131693	G	A	89131693	4	1	48	1	0	0	0	0	0	1	0	0	5128	1066	37	1	2756	1	EML5	14	89131693	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	238836	89131693	18217847	3251	7645										
EML5	161436	broad.mit.edu	37	chr14	89202808	89202808	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcccttgcataattagaaAaggtttatttctttcttgca	6	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:89202808A>T	ENST00000554922.1	-	7	1197	c.949T>A	c.(949-951)Ttt>Att	p.F317I	EML5_ENST00000380664.5_Missense_Mutation_p.F317I|EML5_ENST00000352093.5_Missense_Mutation_p.F317I	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	317				F -> S (in Ref. 2; AAH32685).		cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						ATAATTAGAAAAGGTTTATTT	0.428													52	89					0	0	1	0	0	T	89202808	A	T	89202808	3	4	48	1	0	0	0	0	1	0	0	0	5128	14	1	4	5132	4	EML5	14	89202808	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	71115	89202808	18146732	3252	7646										
TDP1	55775	broad.mit.edu	37	chr14	90429920	90429920	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaggggagggccaggacatTtgggacatgctggataaagg	17	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:90429920T>G	ENST00000335725.4	+	3	712	c.462T>G	c.(460-462)atT>atG	p.I154M	TDP1_ENST00000393454.2_Missense_Mutation_p.I154M|TDP1_ENST00000357382.3_5'UTR|TDP1_ENST00000393452.3_Missense_Mutation_p.I154M|TDP1_ENST00000555565.1_Intron|TDP1_ENST00000555880.1_Missense_Mutation_p.I154M	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	154					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		GCCAGGACATTTGGGACATGC	0.522								Repair of DNA-protein crosslinks					9	63					0	0	1	0	0	G	90429920	T	G	90429920	3	3	48	1	0	0	0	0	1	0	0	0	15786	1829	64	4	464	4	TDP1	14	90429920	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1227112	90429920	16919620	3253	7647										
RPS6KA5	9252	broad.mit.edu	37	chr14	91338638	91338638	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcaacattctgaaggcaaAacccctctctcttgtatttg	5	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:91338638A>G	ENST00000261991.3	-	17	2362	c.2189T>C	c.(2188-2190)tTt>tCt	p.F730S	RPS6KA5_ENST00000536315.2_Missense_Mutation_p.F651S	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	730					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CTGAAGGCAAAACCCCTCTCT	0.458													17	22					0	0	1	0	0	G	91338638	A	G	91338638	3	3	48	1	0	0	0	0	1	0	0	0	13705	14	1	4	223	4	RPS6KA5	14	91338638	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	908718	91338638	16010902	3254	7648										
CATSPERB	79820	broad.mit.edu	37	chr14	92139243	92139243	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggtaaactccagtaccacGctcttggtcaacaagaaatg	9	10	2	1	rs150597625	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:92139243G>A	ENST00000256343.3	-	13	1252	c.1096C>T	c.(1096-1098)Cgt>Tgt	p.R366C		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	366					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CCAGTACCACGCTCTTGGTCA	0.363													31	67					0	0	1	0	0	A	92139243	G	A	92139243	3	1	48	1	0	0	0	0	1	0	0	0	2709	1087	38	1	2314	1	CATSPERB	14	92139243	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	800605	92139243	15210297	3255	7649										
CATSPERB	79820	broad.mit.edu	37	chr14	92159544	92159544	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaggtgaggataactaaaaAatgattcgttaaaaccatat	8	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:92159544A>C	ENST00000256343.3	-	9	913	c.757T>G	c.(757-759)Ttt>Gtt	p.F253V		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	253					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ATAACTAAAAAATGATTCGTT	0.338													20	53					0	0	1	0	0	C	92159544	A	C	92159544	3	2	48	1	0	0	0	0	1	0	0	0	2709	14	1	4	2669	4	CATSPERB	14	92159544	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	20301	92159544	15189996	3256	7650										
CATSPERB	79820	broad.mit.edu	37	chr14	92174488	92174488	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctgttggcatttacctcGaataacatccaatagagttc	7	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:92174488G>A	ENST00000256343.3	-	6	619	c.463C>T	c.(463-465)Cga>Tga	p.R155*		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	155					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.R155*(2)		NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CATTTACCTCGAATAACATCC	0.353													4	37					0	0	1	0	0	A	92174488	G	A	92174488	4	1	48	1	0	0	0	0	0	1	0	0	2709	1066	37	1	2975	1	CATSPERB	14	92174488	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	14944	92174488	15175052	3257	7651										
FBLN5	10516	broad.mit.edu	37	chr14	92353567	92353567	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacgccatcttcctcaagttCatatcctgggtcacagcggc	8	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:92353567C>A	ENST00000267620.10	-	8	1001	c.832G>T	c.(832-834)Gaa>Taa	p.E278*	FBLN5_ENST00000342058.4_Nonsense_Mutation_p.E237*|FBLN5_ENST00000556154.1_Nonsense_Mutation_p.E242*			Q9UBX5	FBLN5_HUMAN	fibulin 5	237	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				TCCTCAAGTTCATATCCTGGG	0.552													70	117					1.05635e-38	1.52265e-38	1	1	0	A	92353567	C	A	92353567	4	1	48	1	0	0	0	0	0	1	0	0	5732	835	29	2	657	2	FBLN5	14	92353567	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	179079	92353567	14995973	3258	7652										
SLC24A4	123041	broad.mit.edu	37	chr14	92958061	92958061	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagcaacgtgtttgacatCctggtaggacttggtgtacc	13	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:92958061C>T	ENST00000532405.1	+	15	1816	c.1590C>T	c.(1588-1590)atC>atT	p.I530I	SLC24A4_ENST00000298877.1_Silent_p.I513I|SLC24A4_ENST00000393265.2_Silent_p.I466I|SLC24A4_ENST00000531433.1_Silent_p.I511I|SLC24A4_ENST00000351924.5_Silent_p.I494I			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	530						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TGTTTGACATCCTGGTAGGAC	0.468													4	63					0	0	1	0	0	T	92958061	C	T	92958061	2	4	48	1	0	0	0	0	0	0	0	1	14522	845	30	3		3	SLC24A4	14	92958061	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	604494	92958061	14391479	3259	7653										
UBR7	55148	broad.mit.edu	37	chr14	93685599	93685599	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaacgcagaatcaaaatcTggctgcaaacttcaggagct	8	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:93685599T>A	ENST00000013070.6	+	8	1088	c.852T>A	c.(850-852)tcT>tcA	p.S284S	UBR7_ENST00000416753.1_Silent_p.S208S	NM_175748.3	NP_786924.2	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin 7 (putative)	284							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|large_intestine(2)|lung(12)|urinary_tract(1)	19						AATCAAAATCTGGCTGCAAAC	0.383													4	31					0	0	1	0	0	A	93685599	T	A	93685599	2	1	48	1	0	0	0	0	0	0	0	1	16966	1567	55	4		4	UBR7	14	93685599	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	727538	93685599	13663941	3260	7654										
DDX24	57062	broad.mit.edu	37	chr14	94545825	94545825	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgagctagactttccctcCtcctcctcctcttcttctga	6	16	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:94545825C>A	ENST00000330836.5	-	2	395	c.264G>T	c.(262-264)gaG>gaT	p.E88D	DDX24_ENST00000555054.1_Missense_Mutation_p.E45D|DDX24_ENST00000544005.1_Intron	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	88	Poly-Glu.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		ACTTTCCCTCCTCCTCCTCCT	0.438													7	94					0.248553	0.24944	1	1	0	A	94545825	C	A	94545825	3	1	48	1	0	0	0	0	1	0	0	0	4374	680	24	5	2347	5	DDX24	14	94545825	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	860226	94545825	12803715	3261	7655										
DICER1	23405	broad.mit.edu	37	chr14	95560464	95560464	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggtagtccaaaatcgcatCtcccaggaattctaagcgct	9	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:95560464C>T	ENST00000526495.1	-	26	5416	c.5125G>A	c.(5125-5127)Gat>Aat	p.D1709N	DICER1_ENST00000343455.3_Missense_Mutation_p.D1709N|DICER1_ENST00000527414.1_Missense_Mutation_p.D1709N|DICER1_ENST00000556045.1_Missense_Mutation_p.D607N|DICER1_ENST00000393063.1_Missense_Mutation_p.D1709N|DICER1_ENST00000541352.1_Missense_Mutation_p.D1709N			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1709	RNase III 2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity	p.D1709N(1)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AAAATCGCATCTCCCAGGAAT	0.527			"Mis F, N"		"sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				31	47					0	0	1	0	0	T	95560464	C	T	95560464	3	4	48	1	0	0	0	0	1	0	0	0	4549	913	32	3	659	3	DICER1	14	95560464	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1014639	95560464	11789076	3262	7656										
TCL1B	9623	broad.mit.edu	37	chr14	96157608	96157608	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctccctctcctgcagattGactctatggagcagctggtc	10	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:96157608G>T	ENST00000340722.7	+	3	388	c.337G>T	c.(337-339)Gac>Tac	p.D113Y	RP11-1070N10.6_ENST00000461160.1_RNA	NM_004918.3	NP_004909.1	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	113										cervix(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		CCTGCAGATTGACTCTATGGA	0.587													18	24					0.00074312	0.000783089	1	1	0	T	96157608	G	T	96157608	3	4	48	1	0	0	0	0	1	0	0	0	15764	1290	45	2	347	2	TCL1B	14	96157608	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	597144	96157608	11191932	3263	7657										
BDKRB1	0	broad.mit.edu	37	chr14	96730613	96730613	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctcccccatgaggcctgGcactttgcaaggattgtgga	11	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:96730613G>A	ENST00000216629.6	+	3	1200	c.594G>A	c.(592-594)tgG>tgA	p.W198*	RP11-404P21.3_ENST00000553638.1_RNA|BDKRB1_ENST00000553356.1_Nonsense_Mutation_p.W198*	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	198					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		ATGAGGCCTGGCACTTTGCAA	0.567													30	43					0	0	1	0	0	A	96730613	G	A	96730613	4	1	48	1	0	0	0	0	0	1	0	0	1390	1212	42	3	596	3	BDKRB1	14	96730613	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	573005	96730613	10618927	3264	7658										
ATG2B	55102	broad.mit.edu	37	chr14	96798990	96798990	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catggagaagaatacttcttCttctagagagaattaaacta	7	6	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:96798990C>A	ENST00000359933.4	-	9	2103	c.1210G>T	c.(1210-1212)Gaa>Taa	p.E404*		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	404										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AATACTTCTTCTTCTAGAGAG	0.378													18	19					5.03518e-11	6.23768e-11	1	1	0	A	96798990	C	A	96798990	4	1	48	1	0	0	0	0	0	1	0	0	1093	922	32	2	5162	2	ATG2B	14	96798990	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	68377	96798990	10550550	3265	7659										
BCL11B	64919	broad.mit.edu	37	chr14	99697799	99697799	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggcagggcgggagagcgcCcagggcacgcagaggtgaag	21	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:99697799C>T	ENST00000357195.3	-	3	532	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	BCL11B_ENST00000345514.2_Intron|BCL11B_ENST00000443726.2_Intron	NM_138576.2	NP_612808.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	175						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGGAGAGCGCCCAGGGCACGC	0.706			T	TLX3	T-ALL								5	20					0	0	1	0	0	T	99697799	C	T	99697799	3	4	48	1	0	0	0	0	1	0	0	0	1362	623	22	3	2169	3	BCL11B	14	99697799	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2898809	99697799	7651741	3266	7660										
EML1	2009	broad.mit.edu	37	chr14	100376649	100376649	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacaccattactggagattCaagtggcaacatcttagtat	8	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:100376649C>A	ENST00000262233.6	+	12	1449	c.1310C>A	c.(1309-1311)tCa>tAa	p.S437*	EML1_ENST00000334192.4_Nonsense_Mutation_p.S456*|EML1_ENST00000327921.9_Nonsense_Mutation_p.S425*	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	437						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				ACTGGAGATTCAAGTGGCAAC	0.343													8	32					2.74318e-10	3.35981e-10	1	1	0	A	100376649	C	A	100376649	4	1	48	1	0	0	0	0	0	1	0	0	5124	838	29	2	1417	2	EML1	14	100376649	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	678850	100376649	6972891	3267	7661										
WARS	7453	broad.mit.edu	37	chr14	100826997	100826997	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aattttactacttccaaaccGaactggaaaaaaagaaaaga	5	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:100826997G>A	ENST00000355338.2	-	4	934	c.316C>T	c.(316-318)Cgg>Tgg	p.R106W	WARS_ENST00000358655.4_Missense_Mutation_p.R65W|WARS_ENST00000554084.1_5'UTR|WARS_ENST00000344102.5_Missense_Mutation_p.R65W|WARS_ENST00000392882.2_Missense_Mutation_p.R106W|WARS_ENST00000557135.1_Missense_Mutation_p.R106W|WARS_ENST00000556645.1_Missense_Mutation_p.R65W	NM_173701.1	NP_776049.1	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase	106					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	CTTCCAAACCGAACTGGAAAA	0.418													31	36					0	0	1	0	0	A	100826997	G	A	100826997	3	1	48	1	0	0	0	0	1	0	0	0	17308	1057	37	1	1131	1	WARS	14	100826997	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	450348	100826997	6522543	3268	7662										
BEGAIN	57596	broad.mit.edu	37	chr14	101005179	101005179	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctcctccgacgtggcgctGaagctggagtaggagctgga	15	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:101005179G>T	ENST00000556751.1	-	5	4121	c.717C>A	c.(715-717)ttC>ttA	p.F239L	BEGAIN_ENST00000443071.2_Missense_Mutation_p.F303L|BEGAIN_ENST00000355173.2_Missense_Mutation_p.F303L			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	303						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				ACGTGGCGCTGAAGCTGGAGT	0.687													5	15					1.23904e-05	1.36503e-05	1	1	0	T	101005179	G	T	101005179	3	4	48	1	0	0	0	0	1	0	0	0	1395	1281	45	2	876	2	BEGAIN	14	101005179	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	178182	101005179	6344361	3269	7663										
DYNC1H1	1778	broad.mit.edu	37	chr14	102502923	102502923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaccagcttcctggatgacGccttcagaaagaacttagag	11	10	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:102502923G>A	ENST00000360184.4	+	57	11016	c.10852G>A	c.(10852-10854)Gcc>Acc	p.A3618T	RP11-1017G21.4_ENST00000557551.1_RNA|DYNC1H1_ENST00000556791.1_3'UTR	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3618	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CCTGGATGACGCCTTCAGAAA	0.468													8	119					0	0	1	0	0	A	102502923	G	A	102502923	3	1	48	1	0	0	0	0	1	0	0	0	4867	1087	38	1	11078	1	DYNC1H1	14	102502923	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1497744	102502923	4846617	3270	7664										
CDC42BPB	9578	broad.mit.edu	37	chr14	103406031	103406031	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggttgggttggatatcatTttggatctcaattctgggtc	12	5	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:103406031T>G	ENST00000361246.2	-	34	5031	c.4743A>C	c.(4741-4743)aaA>aaC	p.K1581N		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1581					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGGATATCATTTTGGATCTCA	0.557													16	166					0	0	1	0	0	G	103406031	T	G	103406031	3	3	48	1	0	0	0	0	1	0	0	0	3095	1838	64	4	408	4	CDC42BPB	14	103406031	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	903108	103406031	3943509	3271	7665										
EIF5	1983	broad.mit.edu	37	chr14	103803151	103803151	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattcattaaaaaatttgttCtctgtcctgaatgtgagaat	7	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:103803151C>A	ENST00000216554.3	+	5	968	c.292C>A	c.(292-294)Ctc>Atc	p.L98I	EIF5_ENST00000558506.1_Missense_Mutation_p.L98I|EIF5_ENST00000392715.2_Missense_Mutation_p.L98I|EIF5_ENST00000560200.1_3'UTR	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	98					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			AAAATTTGTTCTCTGTCCTGA	0.393													19	40					1.56452e-12	1.97515e-12	1	1	0	A	103803151	C	A	103803151	3	1	48	1	0	0	0	0	1	0	0	0	5068	913	32	2	302	2	EIF5	14	103803151	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	397120	103803151	3546389	3272	7666										
KLC1	3831	broad.mit.edu	37	chr14	104143808	104143808	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actttacagacgtcaaggcaAatttgaagctgcagaaacgt	9	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:104143808A>C	ENST00000389744.4	+	12	1705	c.1436A>C	c.(1435-1437)aAa>aCa	p.K479T	KLC1_ENST00000347839.6_Missense_Mutation_p.K479T|KLC1_ENST00000445352.4_Missense_Mutation_p.K477T|KLC1_ENST00000557575.1_Missense_Mutation_p.K479T|RP11-73M18.2_ENST00000472726.2_Missense_Mutation_p.K651T|KLC1_ENST00000380038.3_Missense_Mutation_p.K479T|KLC1_ENST00000555836.1_Missense_Mutation_p.K479T|KLC1_ENST00000557450.1_Missense_Mutation_p.K479T|KLC1_ENST00000246489.7_Missense_Mutation_p.K479T|KLC1_ENST00000348520.6_Missense_Mutation_p.K479T|KLC1_ENST00000452929.2_Missense_Mutation_p.K479T|KLC1_ENST00000554280.1_Missense_Mutation_p.K479T|KLC1_ENST00000553286.1_Missense_Mutation_p.K479T|KLC1_ENST00000334553.6_Missense_Mutation_p.K479T			Q07866	KLC1_HUMAN	kinesin light chain 1	479					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				CGTCAAGGCAAATTTGAAGCT	0.418													45	52					0	0	1	0	0	C	104143808	A	C	104143808	3	2	48	1	0	0	0	0	1	0	0	0	8375	14	1	4	1478	4	KLC1	14	104143808	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	340657	104143808	3205732	3273	7667										
AHNAK2	113146	broad.mit.edu	37	chr14	105406167	105406167	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagctttccagccccgccTctgtccctgaaagagcgcct	8	18	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105406167T>C	ENST00000333244.5	-	7	15740	c.15621A>G	c.(15619-15621)agA>agG	p.R5207R	AHNAK2_ENST00000557457.1_Silent_p.R205R	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5207						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGCCCCGCCTCTGTCCCTGA	0.552													140	150					0	0	1	0	0	C	105406167	T	C	105406167	2	2	48	1	0	0	0	0	0	0	0	1	412	1548	54	4		4	AHNAK2	14	105406167	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1262359	105406167	1943373	3274	7668										
AHNAK2	113146	broad.mit.edu	37	chr14	105407539	105407539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatggctctgaacaagccGaaacctgttgtaattcaaaa	9	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105407539G>A	ENST00000333244.5	-	7	14368	c.14249C>T	c.(14248-14250)tCg>tTg	p.S4750L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4750						nucleus		p.S4750L(1)		cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGAACAAGCCGAAACCTGTTG	0.438													20	55					0	0	1	0	0	A	105407539	G	A	105407539	3	1	48	1	0	0	0	0	1	0	0	0	412	1059	37	1	3142	1	AHNAK2	14	105407539	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1372	105407539	1942001	3275	7669										
AHNAK2	113146	broad.mit.edu	37	chr14	105411964	105411964	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggggcctcgacgtccaccTccatgctgggctgagacacc	12	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105411964T>C	ENST00000333244.5	-	7	9943	c.9824A>G	c.(9823-9825)gAg>gGg	p.E3275G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3275						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GACGTCCACCTCCATGCTGGG	0.627													98	176					0	0	1	0	0	C	105411964	T	C	105411964	3	2	48	1	0	0	0	0	1	0	0	0	412	1551	54	4	7567	4	AHNAK2	14	105411964	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4425	105411964	1937576	3276	7670										
AHNAK2	113146	broad.mit.edu	37	chr14	105413705	105413705	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggggctgaatgctgatgtCagtggtcttaaggtcccctt	15	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105413705C>T	ENST00000333244.5	-	7	8202	c.8083G>A	c.(8083-8085)Gac>Aac	p.D2695N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2695						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATGCTGATGTCAGTGGTCTTA	0.627													12	281					0	0	1	0	0	T	105413705	C	T	105413705	3	4	48	1	0	0	0	0	1	0	0	0	412	826	29	3	9308	3	AHNAK2	14	105413705	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1741	105413705	1935835	3277	7671										
GPR132	29933	broad.mit.edu	37	chr14	105517481	105517481	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcctggtgacgtctgtcttCatggaccactctttccaccc	8	15	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105517481C>A	ENST00000329797.3	-	4	1904	c.993G>T	c.(991-993)atG>atT	p.M331I	GPR132_ENST00000392585.2_Missense_Mutation_p.M322I|GPR132_ENST00000539291.2_Missense_Mutation_p.M331I	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	331					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		CGTCTGTCTTCATGGACCACT	0.612													23	37					6.21321e-17	8.30052e-17	1	1	0	A	105517481	C	A	105517481	3	1	48	1	0	0	0	0	1	0	0	0	6681	826	29	2	153	2	GPR132	14	105517481	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	103776	105517481	1832059	3278	7672										
PACS2	23241	broad.mit.edu	37	chr14	105857575	105857575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaattgtggagccatcctCggccacatcaggtaaccccg	11	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105857575C>T	ENST00000447393.1	+	20	2250	c.2075C>T	c.(2074-2076)tCg>tTg	p.S692L	PACS2_ENST00000430725.2_Missense_Mutation_p.S613L|PACS2_ENST00000458164.2_Missense_Mutation_p.S703L|PACS2_ENST00000551743.1_Missense_Mutation_p.S202L|PACS2_ENST00000547217.1_Missense_Mutation_p.S658L|PACS2_ENST00000325438.8_Missense_Mutation_p.S688L	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	688					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GAGCCATCCTCGGCCACATCA	0.602													21	44					0	0	1	0	0	T	105857575	C	T	105857575	3	4	48	1	0	0	0	0	1	0	0	0	11419	893	31	1	2153	1	PACS2	14	105857575	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	340094	105857575	1491965	3279	7673										
PACS2	23241	broad.mit.edu	37	chr14	105860899	105860899	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctcccacagtcctcatcGacggcgtggagtgcagcgac	11	16	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr14:105860899G>A	ENST00000447393.1	+	24	2747	c.2572G>A	c.(2572-2574)Gac>Aac	p.D858N	PACS2_ENST00000430725.2_Missense_Mutation_p.D779N|PACS2_ENST00000458164.2_Missense_Mutation_p.D869N|PACS2_ENST00000551743.1_Missense_Mutation_p.D368N|PACS2_ENST00000551801.1_Missense_Mutation_p.D55N|PACS2_ENST00000547217.1_Missense_Mutation_p.D824N|PACS2_ENST00000325438.8_Missense_Mutation_p.D854N	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	854					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		AGTCCTCATCGACGGCGTGGA	0.677													25	59					0	0	1	0	0	A	105860899	G	A	105860899	3	1	48	1	0	0	0	0	1	0	0	0	11419	1058	37	1	2666	1	PACS2	14	105860899	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3324	105860899	1488641	3280	7674										
OR4M2	390538	broad.mit.edu	37	chr15	22368874	22368874	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgatggatgcattgcacAgctcttcttcttacactttg	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:22368874A>G	ENST00000332663.2	+	1	397	c.299A>G	c.(298-300)cAg>cGg	p.Q100R	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Q100L(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGCATTGCACAGCTCTTCTTC	0.463													7	368					0	0	1	0	0	G	22368874	A	G	22368874	3	3	48	1	0	0	0	0	1	0	0	0	11123	188	7	4	301	4	OR4M2	15	22368874	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08		22368874	80162518	3281	7675										
OR4N4	283694	broad.mit.edu	37	chr15	22382507	22382507	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacacagtagtgacagaatTtatcctccttggtctgactc	7	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:22382507T>G	ENST00000328795.4	+	1	126	c.35T>G	c.(34-36)tTt>tGt	p.F12C	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GTGACAGAATTTATCCTCCTT	0.348													20	252					0	0	1	0	0	G	22382507	T	G	22382507	3	3	48	1	0	0	0	0	1	0	0	0	11125	1841	64	4	37	4	OR4N4	15	22382507	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	13633	22382507	80148885	3282	7676										
OR4N4	283694	broad.mit.edu	37	chr15	22383340	22383340	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcctatgatttatacccttCgcaaccaggaagtgaaaact	6	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:22383340C>T	ENST00000328795.4	+	1	959	c.868C>T	c.(868-870)Cgc>Tgc	p.R290C	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTATACCCTTCGCAACCAGGA	0.413													15	123					0	0	1	0	0	T	22383340	C	T	22383340	3	4	48	1	0	0	0	0	1	0	0	0	11125	884	31	1	870	1	OR4N4	15	22383340	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	833	22383340	80148052	3283	7677										
CYFIP1	23191	broad.mit.edu	37	chr15	22933766	22933766	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtctctgcagcagcagctcGaagtgatttctggctacgaa	11	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:22933766G>A	ENST00000313077.7	+	8	810	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K	CYFIP1_ENST00000560848.1_Missense_Mutation_p.E229K	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	229					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GCAGCAGCTCGAAGTGATTTC	0.532													53	93					0	0	1	0	0	A	22933766	G	A	22933766	3	1	48	1	0	0	0	0	1	0	0	0	4160	1059	37	1	711	1	CYFIP1	15	22933766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	550426	22933766	79597626	3284	7678										
MAGEL2	54551	broad.mit.edu	37	chr15	23889613	23889613	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attccctgtatggtagcccaGcttgttgatgataatatagg	10	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:23889613G>T	ENST00000532292.1	-	1	1562	c.1468C>A	c.(1468-1470)Ctg>Atg	p.L490M		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGGTAGCCCAGCTTGTTGATG	0.428													12	25					3.07112e-06	3.42433e-06	1	1	0	T	23889613	G	T	23889613	3	4	48	1	0	0	0	0	1	0	0	0	9238	962	34	5	476	5	MAGEL2	15	23889613	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	955847	23889613	78641779	3285	7679										
UBE3A	7337	broad.mit.edu	37	chr15	25615832	25615832	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcgttcactgtacatgcGaattctattgtcataatata	5	8	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:25615832G>A	ENST00000232165.3	-	6	2145	c.1489C>T	c.(1489-1491)Cgc>Tgc	p.R497C	SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000566215.1_Missense_Mutation_p.R477C|UBE3A_ENST00000428984.2_Missense_Mutation_p.R477C|UBE3A_ENST00000438097.1_Missense_Mutation_p.R477C|UBE3A_ENST00000397954.2_Missense_Mutation_p.R500C	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	500	Interaction with HCV core protein.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity	p.R500C(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CTGTACATGCGAATTCTATTG	0.343													15	33					0	0	1	0	0	A	25615832	G	A	25615832	3	1	48	1	0	0	0	0	1	0	0	0	16939	1058	37	1	1161	1	UBE3A	15	25615832	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1726219	25615832	76915560	3286	7680										
ATP10A	57194	broad.mit.edu	37	chr15	25925385	25925385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatagcacgtggcacaagacGcattgtaaatcaaagccacg	10	10	1	1	rs146387652		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:25925385G>A	ENST00000356865.6	-	20	3860	c.3749C>T	c.(3748-3750)gCg>gTg	p.A1250V		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1250					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.A1250V(1)		NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGCACAAGACGCATTGTAAAT	0.493													51	83					0	0	1	0	0	A	25925385	G	A	25925385	3	1	48	1	0	0	0	0	1	0	0	0	1115	1087	38	1	758	1	ATP10A	15	25925385	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	309553	25925385	76606007	3287	7681										
GABRB3	2562	broad.mit.edu	37	chr15	26793009	26793009	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatggaaacacgatcctggaCcatctgtctatggcattcac	8	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:26793009C>T	ENST00000541819.2	-	10	1623	c.1521G>A	c.(1519-1521)tgG>tgA	p.W507*	GABRB3_ENST00000545868.1_Nonsense_Mutation_p.W366*|GABRB3_ENST00000311550.5_Nonsense_Mutation_p.W451*|GABRB3_ENST00000400188.3_Nonsense_Mutation_p.W380*|GABRB3_ENST00000299267.4_Nonsense_Mutation_p.W451*			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	451					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CGATCCTGGACCATCTGTCTA	0.408													7	68					0	0	1	0	0	T	26793009	C	T	26793009	4	4	48	1	0	0	0	0	0	1	0	0	6202	508	18	3	72	3	GABRB3	15	26793009	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	867624	26793009	75738383	3288	7682										
HERC2	8924	broad.mit.edu	37	chr15	28414768	28414768	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcaccacttattttattaCtggcagcagaagaatcagca	7	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:28414768C>A	ENST00000261609.7	-	66	10199	c.10091G>T	c.(10090-10092)aGt>aTt	p.S3364I		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3364					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TATTTTATTACTGGCAGCAGA	0.373													8	80					5.4927e-09	6.54492e-09	1	1	0	A	28414768	C	A	28414768	3	1	48	1	0	0	0	0	1	0	0	0	7098	565	20	5	4525	5	HERC2	15	28414768	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1621759	28414768	74116624	3289	7683										
APBA2	321	broad.mit.edu	37	chr15	29368262	29368262	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatatttcctaacagacaaAgaaggtggcatcatttccaa	6	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:29368262A>C	ENST00000558402.1	+	7	1636	c.1037A>C	c.(1036-1038)aAg>aCg	p.K346T	APBA2_ENST00000558259.1_Missense_Mutation_p.K346T|APBA2_ENST00000558330.1_Missense_Mutation_p.K346T|APBA2_ENST00000561069.1_Missense_Mutation_p.K346T|APBA2_ENST00000411764.1_Missense_Mutation_p.K346T			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	346					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TAACAGACAAAGAAGGTGGCA	0.368													5	67					0	0	1	0	0	C	29368262	A	C	29368262	3	2	48	1	0	0	0	0	1	0	0	0	753	72	3	4	1047	4	APBA2	15	29368262	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	953494	29368262	73163130	3290	7684										
APBA2	321	broad.mit.edu	37	chr15	29406121	29406121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcattgctgagcgagggggcGtccgtgtgggccaccgcatc	17	12	0	1	rs144849809		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:29406121G>A	ENST00000558402.1	+	15	2679	c.2080G>A	c.(2080-2082)Gtc>Atc	p.V694I	APBA2_ENST00000558259.1_Missense_Mutation_p.V694I|APBA2_ENST00000558330.1_Missense_Mutation_p.V682I|APBA2_ENST00000561069.1_Missense_Mutation_p.V694I|APBA2_ENST00000411764.1_Missense_Mutation_p.V682I			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	694	PDZ 2.				nervous system development|protein transport		protein binding	p.V694I(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GCGAGGGGGCGTCCGTGTGGG	0.627													20	47					0	0	1	0	0	A	29406121	G	A	29406121	3	1	48	1	0	0	0	0	1	0	0	0	753	1145	40	1	2122	1	APBA2	15	29406121	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37859	29406121	73125271	3291	7685										
TJP1	7082	broad.mit.edu	37	chr15	30034962	30034962	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccccaggtttagaaattCtctcttcatctctactccgg	6	14	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:30034962C>A	ENST00000346128.6	-	9	1508	c.1034G>T	c.(1033-1035)aGa>aTa	p.R345I	TJP1_ENST00000356107.6_Missense_Mutation_p.R345I|TJP1_ENST00000400011.2_Missense_Mutation_p.R349I|TJP1_ENST00000545208.2_Missense_Mutation_p.R345I	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	345					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TTTAGAAATTCTCTCTTCATC	0.373													14	33					1.05317e-09	1.27574e-09	1	1	0	A	30034962	C	A	30034962	3	1	48	1	0	0	0	0	1	0	0	0	15988	913	32	2	4292	2	TJP1	15	30034962	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	628841	30034962	72496430	3292	7686										
MTMR10	54893	broad.mit.edu	37	chr15	31251300	31251300	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttggtctgctaaagaactTggcactacaatgtattctgg	9	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:31251300T>C	ENST00000435680.1	-	8	880	c.783A>G	c.(781-783)ccA>ccG	p.P261P	MTMR10_ENST00000425768.1_3'UTR|MTMR10_ENST00000563714.1_Silent_p.P179P|MTMR10_ENST00000314404.8_Silent_p.P13P	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	261	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CTAAAGAACTTGGCACTACAA	0.393													4	8					0	0	1	0	0	C	31251300	T	C	31251300	2	2	48	1	0	0	0	0	0	0	0	1	9986	1799	63	4		4	MTMR10	15	31251300	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1216338	31251300	71280092	3293	7687										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32917394	32917394	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taacacagaaaagaagctacGattacaggctgcagtagtac	9	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:32917394G>A	ENST00000361627.3	+	5	1387	c.665G>A	c.(664-666)cGa>cAa	p.R222Q	ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.R33Q|ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.R33Q|ARHGAP11A_ENST00000563864.1_Missense_Mutation_p.R222Q|ARHGAP11A_ENST00000567348.1_Missense_Mutation_p.R222Q	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	222	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		AAGAAGCTACGATTACAGGCT	0.358													28	32					0	0	1	0	0	A	32917394	G	A	32917394	3	1	48	1	0	0	0	0	1	0	0	0	860	1058	37	1	683	1	ARHGAP11A	15	32917394	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1666094	32917394	69613998	3294	7688										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32929102	32929102	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcattcaaatatgccaaaaGattatttaagcaagcaagaa	5	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:32929102G>T	ENST00000361627.3	+	12	2850	c.2128G>T	c.(2128-2130)Gat>Tat	p.D710Y	ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.D521Y|ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.D521Y	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	710					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.D710H(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TATGCCAAAAGATTATTTAAG	0.284													17	26					6.94344e-10	8.4399e-10	1	1	0	T	32929102	G	T	32929102	3	4	48	1	0	0	0	0	1	0	0	0	860	942	33	2	2197	2	ARHGAP11A	15	32929102	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11708	32929102	69602290	3295	7689										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32929515	32929515	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccgtcagaagaattaattcTttgttggagtatagcagaca	9	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:32929515T>G	ENST00000361627.3	+	12	3263	c.2541T>G	c.(2539-2541)tcT>tcG	p.S847S	ARHGAP11A_ENST00000543522.1_Silent_p.S658S|ARHGAP11A_ENST00000565905.1_Silent_p.S658S	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	847					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		GAATTAATTCTTTGTTGGAGT	0.408													40	54					0	0	1	0	0	G	32929515	T	G	32929515	2	3	48	1	0	0	0	0	0	0	0	1	860	1596	56	4		4	ARHGAP11A	15	32929515	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	413	32929515	69601877	3296	7690										
FMN1	342184	broad.mit.edu	37	chr15	33091084	33091084	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcataccacaccataaacaCgtagctgggtgtgatctcct	7	13	2	1	rs76835557	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:33091084C>T	ENST00000334528.9	-	15	3381	c.3382G>A	c.(3382-3384)Gtg>Atg	p.V1128M	FMN1_ENST00000561249.1_Missense_Mutation_p.V1253M|FMN1_ENST00000559047.1_Missense_Mutation_p.V1351M	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	1351	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		ACCATAAACACGTAGCTGGGT	0.398													7	24					0	0	1	0	0	T	33091084	C	T	33091084	3	4	48	1	0	0	0	0	1	0	0	0	5981	536	19	1	220	1	FMN1	15	33091084	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	161569	33091084	69440308	3297	7691										
FMN1	342184	broad.mit.edu	37	chr15	33261472	33261472	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacagggcttgaggaaggtCtctctgtctgtctggacgca	13	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:33261472C>A	ENST00000334528.9	-	4	1760	c.1761G>T	c.(1759-1761)gaG>gaT	p.E587D	FMN1_ENST00000561249.1_Missense_Mutation_p.E712D|FMN1_ENST00000559047.1_Missense_Mutation_p.E810D	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	810	Mediates interaction with alpha-catenin (By similarity).|Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TGAGGAAGGTCTCTCTGTCTG	0.483													24	343					1.64293e-13	2.10822e-13	1	1	0	A	33261472	C	A	33261472	3	1	48	1	0	0	0	0	1	0	0	0	5981	912	32	2	1885	2	FMN1	15	33261472	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	170388	33261472	69269920	3298	7692										
RYR3	6263	broad.mit.edu	37	chr15	33954392	33954392	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctctgtgagcaggaggaccTgatgcggttccattaccaca	12	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:33954392T>G	ENST00000389232.4	+	35	4731	c.4661T>G	c.(4660-4662)cTg>cGg	p.L1554R	RYR3_ENST00000415757.3_Missense_Mutation_p.L1554R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1554	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGGAGGACCTGATGCGGTTC	0.612													6	11					0	0	1	0	0	G	33954392	T	G	33954392	3	3	48	1	0	0	0	0	1	0	0	0	13821	1580	55	4	4799	4	RYR3	15	33954392	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	692920	33954392	68577000	3299	7693										
RYR3	6263	broad.mit.edu	37	chr15	34040342	34040342	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatttatcgctggcctgcgCgagagtccctgaaaaccatg	10	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34040342C>T	ENST00000389232.4	+	54	8087	c.8017C>T	c.(8017-8019)Cga>Tga	p.R2673*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.R2673*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2673	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGGCCTGCGCGAGAGTCCCT	0.527													24	61					0	0	1	0	0	T	34040342	C	T	34040342	4	4	48	1	0	0	0	0	0	1	0	0	13821	760	27	1	8231	1	RYR3	15	34040342	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	85950	34040342	68491050	3300	7694										
RYR3	6263	broad.mit.edu	37	chr15	34049726	34049726	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accagtcattgcctctacttCttgtcatcccctctgaagcc	5	16	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34049726C>A	ENST00000389232.4	+	60	8704	c.8634C>A	c.(8632-8634)ttC>ttA	p.F2878L	RYR3_ENST00000415757.3_Missense_Mutation_p.F2878L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2878					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCTCTACTTCTTGTCATCCC	0.498													7	13					0.0293803	0.0299069	1	1	0	A	34049726	C	A	34049726	3	1	48	1	0	0	0	0	1	0	0	0	13821	912	32	2	8872	2	RYR3	15	34049726	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9384	34049726	68481666	3301	7695										
RYR3	6263	broad.mit.edu	37	chr15	34049795	34049795	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggagaaagaaatggtggcCgggtgagtctacaagataaa	14	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34049795C>T	ENST00000389232.4	+	60	8773	c.8703C>T	c.(8701-8703)gcC>gcT	p.A2901A	RYR3_ENST00000415757.3_Silent_p.A2901A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2901					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AAATGGTGGCCGGGTGAGTCT	0.478													7	8					0	0	1	0	0	T	34049795	C	T	34049795	2	4	48	1	0	0	0	0	0	0	0	1	13821	639	23	1		1	RYR3	15	34049795	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	69	34049795	68481597	3302	7696										
RYR3	6263	broad.mit.edu	37	chr15	34080594	34080594	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctcatcctggacgagttCgcggtcctctgcagagatct	10	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34080594C>T	ENST00000389232.4	+	67	9835	c.9765C>T	c.(9763-9765)ttC>ttT	p.F3255F	RYR3_ENST00000415757.3_Silent_p.F3255F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3255					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGACGAGTTCGCGGTCCTCT	0.567													32	74					0	0	1	0	0	T	34080594	C	T	34080594	2	4	48	1	0	0	0	0	0	0	0	1	13821	883	31	1		1	RYR3	15	34080594	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30799	34080594	68450798	3303	7697										
RYR3	6263	broad.mit.edu	37	chr15	34115220	34115220	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgctagattacctaaaggaGaaaaaggatgctggattctt	10	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34115220G>T	ENST00000389232.4	+	81	11089	c.11019G>T	c.(11017-11019)gaG>gaT	p.E3673D	RYR3_ENST00000415757.3_Missense_Mutation_p.E3668D	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3673					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCTAAAGGAGAAAAAGGATG	0.423													15	49					6.31663e-08	7.35827e-08	1	1	0	T	34115220	G	T	34115220	3	4	48	1	0	0	0	0	1	0	0	0	13821	933	33	2	11341	2	RYR3	15	34115220	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	34626	34115220	68416172	3304	7698										
RYR3	6263	broad.mit.edu	37	chr15	34123245	34123245	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcacaatttttccaaagctCtggcagtcaccaagcagatt	7	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34123245C>A	ENST00000389232.4	+	86	11486	c.11416C>A	c.(11416-11418)Ctg>Atg	p.L3806M	RYR3_ENST00000415757.3_Missense_Mutation_p.L3801M	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3806					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTCCAAAGCTCTGGCAGTCAC	0.378													9	24					1.58986e-06	1.78832e-06	1	1	0	A	34123245	C	A	34123245	3	1	48	1	0	0	0	0	1	0	0	0	13821	912	32	2	11758	2	RYR3	15	34123245	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8025	34123245	68408147	3305	7699										
RYR3	6263	broad.mit.edu	37	chr15	34130278	34130278	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccctacctaggacgcatcGagatcatgggtggggccaag	13	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34130278G>A	ENST00000389232.4	+	89	12167	c.12097G>A	c.(12097-12099)Gag>Aag	p.E4033K	RYR3_ENST00000415757.3_Missense_Mutation_p.E4028K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4033					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGACGCATCGAGATCATGGG	0.488													45	84					0	0	1	0	0	A	34130278	G	A	34130278	3	1	48	1	0	0	0	0	1	0	0	0	13821	1059	37	1	12451	1	RYR3	15	34130278	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7033	34130278	68401114	3306	7700										
CHRM5	0	broad.mit.edu	37	chr15	34356260	34356260	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccagacactgagtgccattCtcctggccttcatcatcaca	6	16	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34356260C>A	ENST00000383263.5	+	3	2012	c.1342C>A	c.(1342-1344)Ctc>Atc	p.L448I	CHRM5_ENST00000557872.1_Missense_Mutation_p.L448I	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	448					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	GAGTGCCATTCTCCTGGCCTT	0.512													31	54					6.38683e-12	8.00204e-12	1	1	0	A	34356260	C	A	34356260	3	1	48	1	0	0	0	0	1	0	0	0	3402	913	32	2	1344	2	CHRM5	15	34356260	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	225982	34356260	68175132	3307	7701										
SLC12A6	9990	broad.mit.edu	37	chr15	34531322	34531322	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccaccaccagctggcagaAtccttttaccttctctgcct	7	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:34531322A>C	ENST00000354181.3	-	20	2968	c.2476T>G	c.(2476-2478)Ttc>Gtc	p.F826V	SLC12A6_ENST00000560611.1_Missense_Mutation_p.F826V|SLC12A6_ENST00000560164.1_Missense_Mutation_p.F638V|SLC12A6_ENST00000458406.2_Missense_Mutation_p.F767V|SLC12A6_ENST00000451844.2_Missense_Mutation_p.F638V|SLC12A6_ENST00000397702.2_Missense_Mutation_p.F767V|SLC12A6_ENST00000397707.2_Missense_Mutation_p.F811V|SLC12A6_ENST00000558589.1_Missense_Mutation_p.F817V|SLC12A6_ENST00000290209.5_Missense_Mutation_p.F775V|SLC12A6_ENST00000558667.1_Missense_Mutation_p.F826V			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	826					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AGCTGGCAGAATCCTTTTACC	0.527													52	101					0	0	1	0	0	C	34531322	A	C	34531322	3	2	48	1	0	0	0	0	1	0	0	0	14441	101	4	4	1004	4	SLC12A6	15	34531322	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	175062	34531322	68000070	3308	7702										
MEIS2	4212	broad.mit.edu	37	chr15	37387806	37387806	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaggaaaaaagtggcttttCggcgcgaacctgtaagaaac	12	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:37387806C>T	ENST00000338564.5	-	5	843	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	MEIS2_ENST00000219869.9_5'UTR|MEIS2_ENST00000382766.2_Missense_Mutation_p.E133K|MEIS2_ENST00000561208.1_Missense_Mutation_p.E133K|MEIS2_ENST00000559561.1_Missense_Mutation_p.E133K|MEIS2_ENST00000559085.1_Missense_Mutation_p.E120K|MEIS2_ENST00000557796.2_Missense_Mutation_p.E120K|MEIS2_ENST00000444725.1_Missense_Mutation_p.E133K|MEIS2_ENST00000424352.2_Missense_Mutation_p.E133K|MEIS2_ENST00000397624.3_Missense_Mutation_p.E45K|MEIS2_ENST00000397620.2_Missense_Mutation_p.E45K|MEIS2_ENST00000340545.5_Missense_Mutation_p.E120K	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	133					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		AGTGGCTTTTCGGCGCGAACC	0.478													16	36					0	0	1	0	0	T	37387806	C	T	37387806	3	4	48	1	0	0	0	0	1	0	0	0	9517	893	31	1	1135	1	MEIS2	15	37387806	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2856484	37387806	65143586	3309	7703										
FAM98B	283742	broad.mit.edu	37	chr15	38766438	38766438	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatatgagtgccgccgacGaatgttaatgaaacgattag	11	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:38766438G>A	ENST00000397609.2	+	6	703	c.668G>A	c.(667-669)cGa>cAa	p.R223Q	FAM98B_ENST00000491535.1_Missense_Mutation_p.R223Q	NM_173611.2	NP_775882.2	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	223						tRNA-splicing ligase complex	protein binding			endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		TGCCGCCGACGAATGTTAATG	0.378													33	75					0	0	1	0	0	A	38766438	G	A	38766438	3	1	48	1	0	0	0	0	1	0	0	0	5689	1058	37	1	690	1	FAM98B	15	38766438	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1378632	38766438	63764954	3310	7704										
PLCB2	5330	broad.mit.edu	37	chr15	40599857	40599857	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttggggggcagcaggacaGggttgagcagagacatggtg	19	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:40599857G>T	ENST00000260402.3	-	1	266	c.17C>A	c.(16-18)cCt>cAt	p.P6H	PLCB2_ENST00000543785.2_Missense_Mutation_p.P6H|PLCB2_ENST00000456256.2_Missense_Mutation_p.P6H|PLCB2_ENST00000557821.1_Missense_Mutation_p.P6H	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	6					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CAGCAGGACAGGGTTGAGCAG	0.607													4	36					0.000602214	0.000636035	1	1	0	T	40599857	G	T	40599857	3	4	48	1	0	0	0	0	1	0	0	0	12075	1000	35	5	3668	5	PLCB2	15	40599857	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1833419	40599857	61931535	3311	7705										
BAHD1	22893	broad.mit.edu	37	chr15	40754371	40754371	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcaaggagcaaggctgccCgcaggcctagccaccccaag	12	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:40754371C>T	ENST00000561234.1	+	3	1949	c.1690C>T	c.(1690-1692)Cgc>Tgc	p.R564C	BAHD1_ENST00000416165.1_Missense_Mutation_p.R565C|BAHD1_ENST00000560846.1_Missense_Mutation_p.R565C			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	565	Arg-rich.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CAAGGCTGCCCGCAGGCCTAG	0.692													39	59					0	0	1	0	0	T	40754371	C	T	40754371	3	4	48	1	0	0	0	0	1	0	0	0	1295	652	23	1	1699	1	BAHD1	15	40754371	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	154514	40754371	61777021	3312	7706										
NDUFAF1	51103	broad.mit.edu	37	chr15	41680707	41680707	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcgattagagaagaaaaatTtggaaaaaggaatctgaaag	10	3	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:41680707T>C	ENST00000260361.4	-	4	1154	c.773A>G	c.(772-774)aAa>aGa	p.K258R		NM_016013.3	NP_057097.2	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	258					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	12		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		GAAGAAAAATTTGGAAAAAGG	0.343													11	26					0	0	1	0	0	C	41680707	T	C	41680707	3	2	48	1	0	0	0	0	1	0	0	0	10320	1841	64	4	218	4	NDUFAF1	15	41680707	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	926336	41680707	60850685	3313	7707										
MGA	23269	broad.mit.edu	37	chr15	42040968	42040968	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtctcaaacacacaactTcagggacatcggatggtctt	8	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:42040968T>G	ENST00000219905.7	+	16	5527	c.5346T>G	c.(5344-5346)ctT>ctG	p.L1782L	MGA_ENST00000545763.1_Silent_p.L1573L|MGA_ENST00000566586.1_Silent_p.L1573L|MGA_ENST00000389936.4_Intron|MGA_ENST00000570161.1_Silent_p.L1782L	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1763						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ACACACAACTTCAGGGACATC	0.488													12	46					0	0	1	0	0	G	42040968	T	G	42040968	2	3	48	1	0	0	0	0	0	0	0	1	9589	1770	62	4		4	MGA	15	42040968	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	360261	42040968	60490424	3314	7708										
JMJD7-PLA2G4B	0	broad.mit.edu	37	chr15	42136685	42136685	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagatcccagtggtagctaTtatggccactggtggtggga	14	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:42136685T>G	ENST00000382448.4	+	17	1598	c.1589T>G	c.(1588-1590)aTt>aGt	p.I530S	JMJD7-PLA2G4B_ENST00000458483.1_Missense_Mutation_p.I299S|PLA2G4B_ENST00000452633.1_Missense_Mutation_p.I299S|JMJD7-PLA2G4B_ENST00000342159.4_Missense_Mutation_p.I530S	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		299	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						GTGGTAGCTATTATGGCCACT	0.572													14	179					0	0	1	0	0	G	42136685	T	G	42136685	3	3	48	1	0	0	0	0	1	0	0	0	7998	1493	52	4	1655	4	JMJD7-PLA2G4B	15	42136685	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	95717	42136685	60394707	3315	7709										
SPTBN5	51332	broad.mit.edu	37	chr15	42143119	42143119	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacggtgctgcaaacaggatCtctgccccactggtcagcct	11	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:42143119C>A	ENST00000320955.6	-	66	11081	c.10854G>T	c.(10852-10854)gaG>gaT	p.E3618D		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3618	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CAAACAGGATCTCTGCCCCAC	0.672													11	11					3.07112e-06	3.42433e-06	1	1	0	A	42143119	C	A	42143119	3	1	48	1	0	0	0	0	1	0	0	0	15177	912	32	2	182	2	SPTBN5	15	42143119	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6434	42143119	60388273	3316	7710										
PLA2G4E	123745	broad.mit.edu	37	chr15	42275988	42275988	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccttcaggcgcttcttcttCtccactgcgagccgcagagc	9	17	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:42275988C>A	ENST00000399518.3	-	20	3057	c.2571G>T	c.(2569-2571)gaG>gaT	p.E857D	CTD-2382E5.1_ENST00000499478.2_RNA|PLA2G4E_ENST00000413860.2_Missense_Mutation_p.E828D	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	845					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GCTTCTTCTTCTCCACTGCGA	0.562													10	11					2.17888e-05	2.39107e-05	1	1	0	A	42275988	C	A	42275988	3	1	48	1	0	0	0	0	1	0	0	0	12052	912	32	2	39	2	PLA2G4E	15	42275988	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	132869	42275988	60255404	3317	7711										
EPB42	2038	broad.mit.edu	37	chr15	43503726	43503726	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcattcttcaggaacacaGcatcctctggtgagaggtgg	11	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:43503726G>T	ENST00000300215.3	-	4	984	c.527C>A	c.(526-528)gCt>gAt	p.A176D	EPB42_ENST00000441366.2_Missense_Mutation_p.A146D|EPB42_ENST00000540029.1_Missense_Mutation_p.A68D			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	146					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CAGGAACACAGCATCCTCTGG	0.572													13	64					2.31682e-05	2.54096e-05	1	1	0	T	43503726	G	T	43503726	3	4	48	1	0	0	0	0	1	0	0	0	5186	971	34	5	1678	5	EPB42	15	43503726	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1227738	43503726	59027666	3318	7712										
ADAL	161823	broad.mit.edu	37	chr15	43628012	43628012	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattgacaagggaaagaaaaGaactttggaagagtaagtgt	13	2	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:43628012G>T	ENST00000422466.2	+	5	756	c.182G>T	c.(181-183)aGa>aTa	p.R61I	ADAL_ENST00000428046.3_Missense_Mutation_p.R61I|ADAL_ENST00000562188.1_Missense_Mutation_p.R61I|ADAL_ENST00000389651.4_Missense_Mutation_p.R61I			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	61					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GGAAAGAAAAGAACTTTGGAA	0.363													32	60					6.53348e-20	8.92126e-20	1	1	0	T	43628012	G	T	43628012	3	4	48	1	0	0	0	0	1	0	0	0	232	942	33	2	188	2	ADAL	15	43628012	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	124286	43628012	58903380	3319	7713										
STRC	161497	broad.mit.edu	37	chr15	43892823	43892823	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagtaggtgggccagaacCtccagttgttcctcagagca	11	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:43892823C>A	ENST00000450892.2	-	26	4979	c.4902G>T	c.(4900-4902)gaG>gaT	p.E1634D	STRC_ENST00000541030.1_Missense_Mutation_p.E861D	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1634					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GGGCCAGAACCTCCAGTTGTT	0.542													17	77					3.45872e-05	3.78815e-05	1	1	0	A	43892823	C	A	43892823	3	1	48	1	0	0	0	0	1	0	0	0	15383	680	24	5	441	5	STRC	15	43892823	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	264811	43892823	58638569	3320	7714										
FRMD5	84978	broad.mit.edu	37	chr15	44180393	44180393	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtagaaggcttggttctcGattccacatttccagaggtg	11	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:44180393G>A	ENST00000417257.1	-	10	1040	c.864C>T	c.(862-864)atC>atT	p.I288I	FRMD5_ENST00000402883.1_Silent_p.I288I|FRMD5_ENST00000484674.1_Silent_p.I194I	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	288	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		CTTGGTTCTCGATTCCACATT	0.448													17	33					0	0	1	0	0	A	44180393	G	A	44180393	2	1	48	1	0	0	0	0	0	0	0	1	6087	1048	37	1		1	FRMD5	15	44180393	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	287570	44180393	58350999	3321	7715										
CASC4	113201	broad.mit.edu	37	chr15	44673090	44673090	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttaattccaggctcaaacTtggacagtgaacccagaatt	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:44673090T>G	ENST00000299957.6	+	8	1287	c.988T>G	c.(988-990)Ttg>Gtg	p.L330V	CASC4_ENST00000360824.3_3'UTR|CASC4_ENST00000345795.2_Missense_Mutation_p.L330V	NM_138423.3	NP_612432.2	Q6P4E1	CASC4_HUMAN	cancer susceptibility candidate 4	330						integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(2)	17		all_cancers(109;1.69e-13)|all_epithelial(112;3.94e-11)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.027)		all cancers(107;2.91e-20)|GBM - Glioblastoma multiforme(94;1.57e-06)|COAD - Colon adenocarcinoma(120;0.217)|Colorectal(105;0.237)		AGGCTCAAACTTGGACAGTGA	0.393													14	35					0	0	1	0	0	G	44673090	T	G	44673090	3	3	48	1	0	0	0	0	1	0	0	0	2680	1606	56	4	1018	4	CASC4	15	44673090	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	492697	44673090	57858302	3322	7716										
CTDSPL2	51496	broad.mit.edu	37	chr15	44789312	44789312	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaaaacaagaagcacaccGgaattctccctagttttaga	7	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:44789312G>A	ENST00000260327.4	+	7	1421	c.858G>A	c.(856-858)ccG>ccA	p.P286P	CTDSPL2_ENST00000558373.1_Silent_p.P214P|CTDSPL2_ENST00000561189.1_3'UTR|CTDSPL2_ENST00000396780.1_Silent_p.P214P|CTDSPL2_ENST00000558966.1_Silent_p.P286P	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	286	FCP1 homology.						phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		GAAGCACACCGGAATTCTCCC	0.358													16	43					0	0	1	0	0	A	44789312	G	A	44789312	2	1	48	1	0	0	0	0	0	0	0	1	4030	1103	39	1		1	CTDSPL2	15	44789312	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	116222	44789312	57742080	3323	7717										
CTDSPL2	51496	broad.mit.edu	37	chr15	44811443	44811443	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaatattcttggaagagatCtttcaaaaactataataatt	4	4	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:44811443C>A	ENST00000260327.4	+	11	1752	c.1189C>A	c.(1189-1191)Ctt>Att	p.L397I	CTDSPL2_ENST00000558373.1_Missense_Mutation_p.L325I|CTDSPL2_ENST00000396780.1_Missense_Mutation_p.L325I|CTDSPL2_ENST00000558966.1_Missense_Mutation_p.L397I	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	397	FCP1 homology.						phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		TGGAAGAGATCTTTCAAAAAC	0.313													17	29					3.52763e-06	3.92945e-06	1	1	0	A	44811443	C	A	44811443	3	1	48	1	0	0	0	0	1	0	0	0	4030	913	32	2	1227	2	CTDSPL2	15	44811443	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22131	44811443	57719949	3324	7718										
SPG11	80208	broad.mit.edu	37	chr15	44943956	44943956	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatctttctgtagaacatTatattgcccatgcattatgt	6	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:44943956T>G	ENST00000261866.7	-	6	1205	c.1189A>C	c.(1189-1191)Aat>Cat	p.N397H	SPG11_ENST00000427534.2_Missense_Mutation_p.N397H|SPG11_ENST00000535302.2_Missense_Mutation_p.N397H|SPG11_ENST00000559193.1_Missense_Mutation_p.N397H|SPG11_ENST00000558319.1_Missense_Mutation_p.N397H	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	397					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGTAGAACATTATATTGCCCA	0.428													34	54					0	0	1	0	0	G	44943956	T	G	44943956	3	3	48	1	0	0	0	0	1	0	0	0	15096	1754	61	4	6282	4	SPG11	15	44943956	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	132513	44943956	57587436	3325	7719										
SEMA6D	80031	broad.mit.edu	37	chr15	48052094	48052094	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgaaccccttaatactgtCgactatcactgtaagtcgtc	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:48052094C>T	ENST00000316364.5	+	2	538	c.99C>T	c.(97-99)gtC>gtT	p.V33V	SEMA6D_ENST00000389433.2_Silent_p.V33V|SEMA6D_ENST00000537942.1_Silent_p.V33V|SEMA6D_ENST00000358066.4_Silent_p.V33V|SEMA6D_ENST00000536845.2_Silent_p.V33V|SEMA6D_ENST00000389432.2_Silent_p.V33V|SEMA6D_ENST00000354744.4_Silent_p.V33V|SEMA6D_ENST00000355997.3_Silent_p.V33V|SEMA6D_ENST00000558014.1_Silent_p.V33V|SEMA6D_ENST00000389428.3_Silent_p.V33V|SEMA6D_ENST00000558816.1_Silent_p.V33V|SEMA6D_ENST00000389425.3_Silent_p.V33V	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	33	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTAATACTGTCGACTATCACT	0.438													14	22					0	0	1	0	0	T	48052094	C	T	48052094	2	4	48	1	0	0	0	0	0	0	0	1	14095	871	31	1		1	SEMA6D	15	48052094	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3108138	48052094	54479298	3326	7720										
SEMA6D	80031	broad.mit.edu	37	chr15	48060931	48060931	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgattttactgatcctttatCgggtatcccaaagggtaagg	10	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:48060931C>T	ENST00000316364.5	+	18	2358	c.1919C>T	c.(1918-1920)tCg>tTg	p.S640L	SEMA6D_ENST00000389433.2_Missense_Mutation_p.S621L|SEMA6D_ENST00000537942.1_Intron|SEMA6D_ENST00000358066.4_Intron|SEMA6D_ENST00000536845.2_Missense_Mutation_p.S640L|SEMA6D_ENST00000389432.2_Intron|SEMA6D_ENST00000354744.4_Intron|SEMA6D_ENST00000355997.3_Intron|SEMA6D_ENST00000558014.1_Intron|SEMA6D_ENST00000389428.3_Intron|SEMA6D_ENST00000558816.1_Intron	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	640					axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GATCCTTTATCGGGTATCCCA	0.448													4	74					0	0	1	0	0	T	48060931	C	T	48060931	3	4	48	1	0	0	0	0	1	0	0	0	14095	893	31	1	2028	1	SEMA6D	15	48060931	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8837	48060931	54470461	3327	7721										
SLC24A5	283652	broad.mit.edu	37	chr15	48434526	48434526	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaattattggaaataataAaataaggggctgtggaggtt	13	1	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:48434526A>C	ENST00000341459.3	+	9	1554	c.1481A>C	c.(1480-1482)aAa>aCa	p.K494T	SLC24A5_ENST00000449382.2_Missense_Mutation_p.K434T|MYEF2_ENST00000267836.6_3'UTR|MYEF2_ENST00000324324.7_3'UTR	NM_205850.2	NP_995322.1	Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	494					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		GGAAATAATAAAATAAGGGGC	0.348													5	29					0	0	1	0	0	C	48434526	A	C	48434526	3	2	48	1	0	0	0	0	1	0	0	0	14523	14	1	4	1515	4	SLC24A5	15	48434526	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	373595	48434526	54096866	3328	7722										
SLC12A1	6557	broad.mit.edu	37	chr15	48580301	48580301	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaaccagaaactggtggaAgccagcactcaatttaaaaa	7	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:48580301A>C	ENST00000396577.3	+	22	2906	c.2691A>C	c.(2689-2691)gaA>gaC	p.E897D	SLC12A1_ENST00000380993.3_Missense_Mutation_p.E897D|SLC12A1_ENST00000558405.1_Missense_Mutation_p.E897D	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	897					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	AACTGGTGGAAGCCAGCACTC	0.403													6	9					0	0	1	0	0	C	48580301	A	C	48580301	3	2	48	1	0	0	0	0	1	0	0	0	14436	69	3	4	2873	4	SLC12A1	15	48580301	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	145775	48580301	53951091	3329	7723										
SLC12A1	6557	broad.mit.edu	37	chr15	48594949	48594949	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccttcatgtcattaggaGccttcccgtggcaagaaagg	10	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:48594949G>A	ENST00000396577.3	+	27	3382	c.3167G>A	c.(3166-3168)aGc>aAc	p.S1056N	SLC12A1_ENST00000380993.3_Missense_Mutation_p.S1056N|SLC12A1_ENST00000558405.1_Missense_Mutation_p.S1056N	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	1056					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GTCATTAGGAGCCTTCCCGTG	0.388													13	30					0	0	1	0	0	A	48594949	G	A	48594949	3	1	48	1	0	0	0	0	1	0	0	0	14436	971	34	3	3369	3	SLC12A1	15	48594949	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	14648	48594949	53936443	3330	7724										
FBN1	2200	broad.mit.edu	37	chr15	48776136	48776136	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggattatcttcacactcatcGatgtctgcaaagaataaaac	6	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:48776136G>A	ENST00000316623.5	-	31	4172	c.3717C>T	c.(3715-3717)atC>atT	p.I1239I		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1239	EGF-like 20; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CACACTCATCGATGTCTGCAA	0.413													14	25					0	0	1	0	0	A	48776136	G	A	48776136	2	1	48	1	0	0	0	0	0	0	0	1	5734	1048	37	1		1	FBN1	15	48776136	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	181187	48776136	53755256	3331	7725										
CEP152	22995	broad.mit.edu	37	chr15	49083511	49083511	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaagctgtatctctctttCttttccattctgaaagagtt	5	9	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:49083511C>A	ENST00000380950.2	-	8	1082	c.895G>T	c.(895-897)Gaa>Taa	p.E299*	CEP152_ENST00000399334.3_Nonsense_Mutation_p.E299*|CEP152_ENST00000325747.5_Nonsense_Mutation_p.E206*	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	299					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		ATCTCTCTTTCTTTTCCATTC	0.338													13	15					1.5842e-08	1.87418e-08	1	1	0	A	49083511	C	A	49083511	4	1	48	1	0	0	0	0	0	1	0	0	3270	922	32	2	4145	2	CEP152	15	49083511	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	307375	49083511	53447881	3332	7726										
SECISBP2L	9728	broad.mit.edu	37	chr15	49305000	49305000	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtctttagtgtgaaaagAagctgcagtaaccactaaaa	9	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:49305000A>G	ENST00000559471.1	-	12	1839	c.1576T>C	c.(1576-1578)Tct>Cct	p.S526P	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.S481P	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	526										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						GTGTGAAAAGAAGCTGCAGTA	0.348													4	47					0	0	1	0	0	G	49305000	A	G	49305000	3	3	48	1	0	0	0	0	1	0	0	0	14060	246	9	4	1757	4	SECISBP2L	15	49305000	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	221489	49305000	53226392	3333	7727										
FGF7	2252	broad.mit.edu	37	chr15	49775360	49775360	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttgcagatatcatggaaaTcaggacagtggcagttggaa	12	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:49775360T>G	ENST00000267843.4	+	3	910	c.299T>G	c.(298-300)aTc>aGc	p.I100S	FAM227B_ENST00000299338.6_Intron|FAM227B_ENST00000561064.1_Intron|FGF7_ENST00000560704.1_3'UTR	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	100					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	ATCATGGAAATCAGGACAGTG	0.373													14	44					0	0	1	0	0	G	49775360	T	G	49775360	3	3	48	1	0	0	0	0	1	0	0	0	5889	1435	50	4	305	4	FGF7	15	49775360	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	470360	49775360	52756032	3334	7728										
ATP8B4	79895	broad.mit.edu	37	chr15	50366349	50366349	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actggaacttttcattatatTcacggtcattggctttcact	6	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:50366349T>C	ENST00000284509.6	-	3	203	c.62A>G	c.(61-63)gAa>gGa	p.E21G	ATP8B4_ENST00000559829.1_Missense_Mutation_p.E21G	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	21					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCATTATATTCACGGTCATT	0.368													17	30					0	0	1	0	0	C	50366349	T	C	50366349	3	2	48	1	0	0	0	0	1	0	0	0	1195	1783	62	4	3620	4	ATP8B4	15	50366349	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	590989	50366349	52165043	3335	7729										
USP8	9101	broad.mit.edu	37	chr15	50769684	50769684	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagccagtgcctagtataaaGaatgttccacaggtatgttc	9	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:50769684G>T	ENST00000433963.1	+	11	1706	c.1206G>T	c.(1204-1206)aaG>aaT	p.K402N	USP8_ENST00000396444.3_Missense_Mutation_p.K402N|USP8_ENST00000425032.3_Missense_Mutation_p.K325N|USP8_ENST00000307179.4_Missense_Mutation_p.K402N	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	402					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTAGTATAAAGAATGTTCCAC	0.373													29	48					4.22769e-11	5.2466e-11	1	1	0	T	50769684	G	T	50769684	3	4	48	1	0	0	0	0	1	0	0	0	17148	933	33	2	1240	2	USP8	15	50769684	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	403335	50769684	51761708	3336	7730										
AP4E1	23431	broad.mit.edu	37	chr15	51201024	51201024	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcgctgccgggactctttCtgcagaaccagcccggtggt	14	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:51201024C>A	ENST00000261842.5	+	1	155	c.49C>A	c.(49-51)Ctg>Atg	p.L17M	AP4E1_ENST00000560508.1_5'UTR	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	17					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		GGGACTCTTTCTGCAGAACCA	0.721													9	10					0.000442599	0.00046913	1	1	0	A	51201024	C	A	51201024	3	1	48	1	0	0	0	0	1	0	0	0	748	912	32	2	51	2	AP4E1	15	51201024	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	431340	51201024	51330368	3337	7731										
AP4E1	23431	broad.mit.edu	37	chr15	51285572	51285572	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcaacctccttaggacaaAtagcttgaagctggaaggta	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:51285572A>C	ENST00000261842.5	+	17	2202	c.2096A>C	c.(2095-2097)aAt>aCt	p.N699T	AP4E1_ENST00000560508.1_Missense_Mutation_p.N624T	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	699					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		CTTAGGACAAATAGCTTGAAG	0.388													6	24					0	0	1	0	0	C	51285572	A	C	51285572	3	2	48	1	0	0	0	0	1	0	0	0	748	101	4	4	2162	4	AP4E1	15	51285572	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	84548	51285572	51245820	3338	7732										
MYO5C	55930	broad.mit.edu	37	chr15	52538226	52538226	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgcagctgctgaacaattcTtttggagtcaaatctttaaa	7	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:52538226T>A	ENST00000261839.7	-	17	2154	c.1993A>T	c.(1993-1995)Aga>Tga	p.R665*	MYO5C_ENST00000443683.2_3'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	665	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		TGAACAATTCTTTTGGAGTCA	0.458													5	17					0	0	1	0	0	A	52538226	T	A	52538226	4	1	48	1	0	0	0	0	0	1	0	0	10127	1617	56	4	3335	4	MYO5C	15	52538226	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1252654	52538226	49993166	3339	7733										
MYO5A	4644	broad.mit.edu	37	chr15	52718065	52718065	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttcttcagctactgcaaaGatatgtggatccatatcacc	7	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:52718065G>T	ENST00000399231.3	-	4	660	c.417C>A	c.(415-417)atC>atA	p.I139I	MYO5A_ENST00000356338.6_Silent_p.I139I|MYO5A_ENST00000553916.1_Silent_p.I139I|MYO5A_ENST00000399233.2_Silent_p.I139I|MYO5A_ENST00000358212.6_Silent_p.I139I	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	139	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTACTGCAAAGATATGTGGAT	0.363													20	32					4.63292e-17	6.19965e-17	1	1	0	T	52718065	G	T	52718065	2	4	48	1	0	0	0	0	0	0	0	1	10125	932	33	2		2	MYO5A	15	52718065	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	179839	52718065	49813327	3340	7734										
WDR72	256764	broad.mit.edu	37	chr15	54005024	54005024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcagtatatgtgcaaaatCgaattgtctggcagttcaag	9	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:54005024C>T	ENST00000396328.1	-	7	895	c.656G>A	c.(655-657)cGa>cAa	p.R219Q	WDR72_ENST00000559418.1_Missense_Mutation_p.R219Q|WDR72_ENST00000360509.5_Missense_Mutation_p.R219Q|WDR72_ENST00000557913.1_Missense_Mutation_p.R218Q	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	219										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TGTGCAAAATCGAATTGTCTG	0.323													3	13					0	0	1	0	0	T	54005024	C	T	54005024	3	4	48	1	0	0	0	0	1	0	0	0	17381	884	31	1	2708	1	WDR72	15	54005024	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1286959	54005024	48526368	3341	7735										
UNC13C	440279	broad.mit.edu	37	chr15	54307590	54307590	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacagtggctcttcattaatGgggagatttcggacattatc	11	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:54307590G>T	ENST00000545554.1	+	1	2490	c.2490G>T	c.(2488-2490)atG>atT	p.M830I	UNC13C_ENST00000537900.1_Missense_Mutation_p.M830I|UNC13C_ENST00000260323.11_Missense_Mutation_p.M830I			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	830					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTTCATTAATGGGGAGATTTC	0.443													26	35					1.26454e-06	1.4261e-06	1	1	0	T	54307590	G	T	54307590	3	4	48	1	0	0	0	0	1	0	0	0	17045	1348	47	5	2492	5	UNC13C	15	54307590	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	302566	54307590	48223802	3342	7736										
CCPG1	9236	broad.mit.edu	37	chr15	55652205	55652205	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctttccttccatcatttTgcatagtagggcctctatta	5	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:55652205T>C	ENST00000310958.6	-	8	2064	c.1766A>G	c.(1765-1767)cAa>cGa	p.Q589R	CCPG1_ENST00000425574.3_Intron|CCPG1_ENST00000569205.1_Missense_Mutation_p.Q589R|CCPG1_ENST00000442196.3_Missense_Mutation_p.Q589R|DYX1C1-CCPG1_ENST00000565113.1_RNA	NM_001204450.1|NM_001204451.1|NM_004748.4|NM_020739.3	NP_001191379.1|NP_001191380.1|NP_004739.3|NP_065790.2	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1	589					cell cycle	integral to membrane				autonomic_ganglia(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|stomach(3)	30				all cancers(107;0.0354)		TCCATCATTTTGCATAGTAGG	0.348													35	62					0	0	1	0	0	C	55652205	T	C	55652205	3	2	48	1	0	0	0	0	1	0	0	0	2960	1812	63	4	511	4	CCPG1	15	55652205	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1344615	55652205	46879187	3343	7737										
DYX1C1	161582	broad.mit.edu	37	chr15	55759161	55759161	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttctagatgccaaatttcTagtaagactcttatatttta	4	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:55759161T>G	ENST00000321149.3	-	5	971	c.604A>C	c.(604-606)Aga>Cga	p.R202R	DYX1C1_ENST00000380679.1_Silent_p.R202R|DYX1C1_ENST00000457155.2_Silent_p.R202R|DYX1C1_ENST00000448430.2_Silent_p.R202R|DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000348518.3_Silent_p.R202R	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	202					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		GCCAAATTTCTAGTAAGACtc	0.289													11	31					0	0	1	0	0	G	55759161	T	G	55759161	2	3	48	1	0	0	0	0	0	0	0	1	4888	1530	53	4		4	DYX1C1	15	55759161	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	106956	55759161	46772231	3344	7738										
PRTG	283659	broad.mit.edu	37	chr15	55912375	55912375	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgagaagctggttgtctgAcctggggagctaggggagtc	17	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:55912375A>G	ENST00000389286.4	-	20	3335	c.3288T>C	c.(3286-3288)ggT>ggC	p.G1096G		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1096					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TGGTTGTCTGACCTGGGGAGC	0.488													35	60					0	0	1	0	0	G	55912375	A	G	55912375	2	3	48	1	0	0	0	0	0	0	0	1	12686	262	10	4		4	PRTG	15	55912375	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	153214	55912375	46619017	3345	7739										
RFX7	64864	broad.mit.edu	37	chr15	56388073	56388073	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagagtgatagtgctttgaTtattgcctgttgacgtgcct	11	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:56388073T>C	ENST00000423270.1	-	9	1852	c.1853A>G	c.(1852-1854)aAt>aGt	p.N618S	RFX7_ENST00000422057.1_Missense_Mutation_p.N521S|RFX7_ENST00000317318.6_Missense_Mutation_p.N618S|RFX7_ENST00000559447.2_Missense_Mutation_p.N521S	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	521					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						AGTGCTTTGATTATTGCCTGT	0.413													21	18					0	0	1	0	0	C	56388073	T	C	56388073	3	2	48	1	0	0	0	0	1	0	0	0	13319	1493	52	4	2533	4	RFX7	15	56388073	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	475698	56388073	46143319	3346	7740										
MNS1	55329	broad.mit.edu	37	chr15	56748713	56748713	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctttcaatctcttgttttCttctgcctgaacgaaaaatt	4	9	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:56748713C>A	ENST00000260453.3	-	3	396	c.232G>T	c.(232-234)Gaa>Taa	p.E78*		NM_018365.2	NP_060835.1	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	78	Glu-rich.				meiosis			p.E78*(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	20				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		CTCTTGTTTTCTTCTGCCTGA	0.333													6	28					5.18039e-06	5.75679e-06	1	1	0	A	56748713	C	A	56748713	4	1	48	1	0	0	0	0	0	1	0	0	9725	922	32	2	1287	2	MNS1	15	56748713	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	360640	56748713	45782679	3347	7741										
TCF12	6938	broad.mit.edu	37	chr15	57511760	57511760	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctggaatgggcagcaattCtttgatgtattactacaatg	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:57511760C>A	ENST00000343827.3	+	1	97	c.41C>A	c.(40-42)tCt>tAt	p.S14Y	TCF12_ENST00000543579.1_Missense_Mutation_p.S14Y|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000333725.5_Intron|TCF12_ENST00000537840.1_5'UTR|TCF12_ENST00000267811.5_Intron|TCF12_ENST00000452095.2_Intron|TCF12_ENST00000438423.2_Intron|TCF12_ENST00000557843.1_Intron	NM_207040.1	NP_996923.1	Q99081	HTF4_HUMAN	transcription factor 12	0					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GGCAGCAATTCTTTGATGTAT	0.358			T	TEC	extraskeletal myxoid chondrosarcoma								7	11					5.18039e-06	5.75679e-06	1	1	0	A	57511760	C	A	57511760	3	1	48	1	0	0	0	0	1	0	0	0	15746	913	32	2	650	2	TCF12	15	57511760	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	763047	57511760	45019632	3348	7742										
TCF12	6938	broad.mit.edu	37	chr15	57555431	57555431	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaagtcagatgatgaatcCtcccaaaaagatatcaaggt	8	7	2	5	rs151235578	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:57555431C>A	ENST00000267811.5	+	17	1936	c.1632C>A	c.(1630-1632)tcC>tcA	p.S544S	TCF12_ENST00000543579.1_Silent_p.S398S|TCF12_ENST00000333725.5_Silent_p.S568S|TCF12_ENST00000343827.3_Silent_p.S374S|TCF12_ENST00000537840.1_Silent_p.S308S|TCF12_ENST00000559703.1_Silent_p.S202S|TCF12_ENST00000452095.2_Silent_p.S564S|TCF12_ENST00000559710.1_Silent_p.S178S|TCF12_ENST00000438423.2_Silent_p.S568S|TCF12_ENST00000557843.1_Silent_p.S544S	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12	544					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATGATGAATCCTCCCAAAAAG	0.343			T	TEC	extraskeletal myxoid chondrosarcoma								5	34					0.014758	0.015099	1	1	0	A	57555431	C	A	57555431	2	1	48	1	0	0	0	0	0	0	0	1	15746	668	24	5		5	TCF12	15	57555431	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	43671	57555431	44975961	3349	7743										
SLTM	79811	broad.mit.edu	37	chr15	59179667	59179667	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatttttgggatatctttcGaagcttggatcttcccttcg	8	8	2	0	rs148004381	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:59179667G>A	ENST00000380516.2	-	18	2535	c.2448C>T	c.(2446-2448)ttC>ttT	p.F816F	SLTM_ENST00000536328.1_Silent_p.F385F	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	816	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GATATCTTTCGAAGCTTGGAT	0.448													20	41					0	0	1	0	0	A	59179667	G	A	59179667	2	1	48	1	0	0	0	0	0	0	0	1	14807	1049	37	1		1	SLTM	15	59179667	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1624236	59179667	43351725	3350	7744										
CCNB2	9133	broad.mit.edu	37	chr15	59399854	59399854	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaaaccagtacagatggaAaagttggctccaaaggtagg	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:59399854A>C	ENST00000288207.2	+	3	443	c.252A>C	c.(250-252)gaA>gaC	p.E84D	CCNB2_ENST00000559622.1_Intron	NM_004701.3	NP_004692.1	O95067	CCNB2_HUMAN	cyclin B2	84					cell cycle checkpoint|cell division|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus	protein kinase binding			kidney(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9						TACAGATGGAAAAGTTGGCTC	0.403													16	39					0	0	1	0	0	C	59399854	A	C	59399854	3	2	48	1	0	0	0	0	1	0	0	0	2935	11	1	4	262	4	CCNB2	15	59399854	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	220187	59399854	43131538	3351	7745										
NARG2	79664	broad.mit.edu	37	chr15	60741464	60741464	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgtatcactgctgcagaGaactgtatcttcagtttttg	8	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:60741464G>T	ENST00000261520.4	-	10	1936	c.1702C>A	c.(1702-1704)Ctc>Atc	p.L568I	NARG2_ENST00000439632.1_Missense_Mutation_p.L431I	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	568						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						CTGCTGCAGAGAACTGTATCT	0.368													26	37					6.32553e-13	8.04352e-13	1	1	0	T	60741464	G	T	60741464	3	4	48	1	0	0	0	0	1	0	0	0	10216	942	33	2	1274	2	NARG2	15	60741464	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1341610	60741464	41789928	3352	7746										
NARG2	79664	broad.mit.edu	37	chr15	60748989	60748989	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcaatgcaagctcttaaaAttttctgagaaacagaaatt	6	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:60748989A>C	ENST00000261520.4	-	6	767	c.533T>G	c.(532-534)aTt>aGt	p.I178S	NARG2_ENST00000439632.1_Missense_Mutation_p.I41S|NARG2_ENST00000561114.1_Missense_Mutation_p.I178S	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	178						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						AGCTCTTAAAATTTTCTGAGA	0.303													15	29					0	0	1	0	0	C	60748989	A	C	60748989	3	2	48	1	0	0	0	0	1	0	0	0	10216	101	4	4	2459	4	NARG2	15	60748989	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7525	60748989	41782403	3353	7747										
VPS13C	54832	broad.mit.edu	37	chr15	62306143	62306143	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acataataccttgtatataaTtttgtctgcttcatttaata	3	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:62306143T>G	ENST00000261517.5	-	10	806	c.733A>C	c.(733-735)Att>Ctt	p.I245L	VPS13C_ENST00000395896.4_Missense_Mutation_p.I245L|VPS13C_ENST00000395898.3_Missense_Mutation_p.I202L|VPS13C_ENST00000249837.3_Missense_Mutation_p.I202L	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	245					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TTGTATATAATTTTGTCTGCT	0.318													13	25					0	0	1	0	0	G	62306143	T	G	62306143	3	3	48	1	0	0	0	0	1	0	0	0	17250	1493	52	4	10860	4	VPS13C	15	62306143	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1557154	62306143	40225249	3354	7748										
VPS13C	54832	broad.mit.edu	37	chr15	62315708	62315708	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatgtatcctttttggcttCttttggcttatctattaaaa	5	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:62315708C>A	ENST00000261517.5	-	8	599	c.526G>T	c.(526-528)Gaa>Taa	p.E176*	VPS13C_ENST00000395896.4_Nonsense_Mutation_p.E176*|VPS13C_ENST00000395898.3_Nonsense_Mutation_p.E133*|VPS13C_ENST00000249837.3_Nonsense_Mutation_p.E133*	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	176	Lys-rich.				protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TTTTTGGCTTCTTTTGGCTTA	0.279													5	9					0.000602214	0.000636035	1	1	0	A	62315708	C	A	62315708	4	1	48	1	0	0	0	0	0	1	0	0	17250	922	32	2	11075	2	VPS13C	15	62315708	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9565	62315708	40215684	3355	7749										
HERC1	8925	broad.mit.edu	37	chr15	63970231	63970231	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgcaaagagtcctcagctGcagctctgagaggtcagcga	12	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:63970231G>A	ENST00000443617.2	-	37	6970	c.6883C>T	c.(6883-6885)Cag>Tag	p.Q2295*	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2295					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GTCCTCAGCTGCAGCTCTGAG	0.512													39	59					0	0	1	0	0	A	63970231	G	A	63970231	4	1	48	1	0	0	0	0	0	1	0	0	7097	1328	46	3	7870	3	HERC1	15	63970231	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1654523	63970231	38561161	3356	7750										
HERC1	8925	broad.mit.edu	37	chr15	63972977	63972977	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccttcacaatataaaacTaaaataaaagtgggatattc	4	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:63972977T>A	ENST00000443617.2	-	35	6313		c.e35-2		RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						AATATAAAACTAAAATAAAAG	0.313													23	30					0	0	1	0	0	A	63972977	T	A	63972977	5	1	48	1	0	0	0	0	0	0	1	0	7097	1536	53	4	8537	4	HERC1	15	63972977	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2746	63972977	38558415	3357	7751										
ANKDD1A	348094	broad.mit.edu	37	chr15	65223707	65223707	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtctgactgccctgcattCggctgctggaggatcccacc	12	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:65223707C>T	ENST00000380230.3	+	8	721	c.692C>T	c.(691-693)tCg>tTg	p.S231L	ANKDD1A_ENST00000395723.1_Missense_Mutation_p.S140L|ANKDD1A_ENST00000496660.1_Missense_Mutation_p.S140L|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.S231L|ANKDD1A_ENST00000491145.1_3'UTR|ANKDD1A_ENST00000319580.8_3'UTR|ANKDD1A_ENST00000357698.3_Missense_Mutation_p.S231L	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	231					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						GCCCTGCATTCGGCTGCTGGA	0.622													16	24					0	0	1	0	0	T	65223707	C	T	65223707	3	4	48	1	0	0	0	0	1	0	0	0	620	893	31	1	722	1	ANKDD1A	15	65223707	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1250730	65223707	37307685	3358	7752										
MTFMT	123263	broad.mit.edu	37	chr15	65295412	65295412	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcctaactactcaatgcaTtgttgcatagcaacagtttt	5	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:65295412T>C	ENST00000220058.4	-	9	1171	c.1158A>G	c.(1156-1158)caA>caG	p.Q386Q		NM_139242.3	NP_640335.2	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	386						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(3)	10					Tetrahydrofolic acid(DB00116)	ACTCAATGCATTGTTGCATAG	0.323													6	27					0	0	1	0	0	C	65295412	T	C	65295412	2	2	48	1	0	0	0	0	0	0	0	1	9971	1490	52	4		4	MTFMT	15	65295412	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	71705	65295412	37235980	3359	7753										
CILP	8483	broad.mit.edu	37	chr15	65489882	65489882	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgatccccctcaatctggtaGaaccggaagtgggctgcact	11	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:65489882G>T	ENST00000261883.4	-	9	2908	c.2742C>A	c.(2740-2742)ttC>ttA	p.F914L		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	914					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CAATCTGGTAGAACCGGAAGT	0.547													33	62					2.68265e-12	3.37613e-12	1	1	0	T	65489882	G	T	65489882	3	4	48	1	0	0	0	0	1	0	0	0	3451	933	33	2	816	2	CILP	15	65489882	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	194470	65489882	37041510	3360	7754										
DENND4A	10260	broad.mit.edu	37	chr15	65959785	65959785	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttaatttttagtctcatAcctttgaatacttgttacag	4	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:65959785A>G	ENST00000443035.3	-	29	5454		c.e29+1		DENND4A_ENST00000431932.2_Splice_Site	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TTAGTCTCATACCTTTGAATA	0.333													16	27					0	0	1	0	0	G	65959785	A	G	65959785	5	3	48	1	0	0	0	0	0	0	1	0	4461	405	14	4	500	4	DENND4A	15	65959785	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	469903	65959785	36571607	3361	7755										
DENND4A	10260	broad.mit.edu	37	chr15	66048662	66048662	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaacatctgtaataggttCttttggtttagctactttat	7	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:66048662C>A	ENST00000443035.3	-	3	342	c.127G>T	c.(127-129)Gaa>Taa	p.E43*	DENND4A_ENST00000431932.2_Nonsense_Mutation_p.E43*	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	43	MABP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.E43*(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						GTAATAGGTTCTTTTGGTTTA	0.373													6	15					5.9392e-07	6.75488e-07	1	1	0	A	66048662	C	A	66048662	4	1	48	1	0	0	0	0	0	1	0	0	4461	922	32	2	5717	2	DENND4A	15	66048662	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	88877	66048662	36482730	3362	7756										
MEGF11	84465	broad.mit.edu	37	chr15	66206168	66206168	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctctttctgccgccgccGatgccaggcaaataggccca	9	16	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:66206168G>A	ENST00000409699.2	-	20	2789	c.2617C>T	c.(2617-2619)Cgg>Tgg	p.R873W	MEGF11_ENST00000422354.1_Missense_Mutation_p.R873W|MEGF11_ENST00000288745.3_Missense_Mutation_p.R798W|MEGF11_ENST00000360698.4_3'UTR|MEGF11_ENST00000478721.1_5'UTR|MEGF11_ENST00000395614.1_Missense_Mutation_p.R46W|MEGF11_ENST00000395625.2_Missense_Mutation_p.R798W			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	873						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						TGCCGCCGCCGATGCCAGGCA	0.612													12	46					0	0	1	0	0	A	66206168	G	A	66206168	3	1	48	1	0	0	0	0	1	0	0	0	9510	1057	37	1	533	1	MEGF11	15	66206168	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	157506	66206168	36325224	3363	7757										
DIS3L	115752	broad.mit.edu	37	chr15	66599214	66599214	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcgcgtcatgattgcattCtctttgctaatgaattccag	8	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:66599214C>A	ENST00000319194.5	+	3	358	c.97C>A	c.(97-99)Ctc>Atc	p.L33I	DIS3L_ENST00000441424.2_Intron|DIS3L_ENST00000319212.4_Missense_Mutation_p.L116I	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	116					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TGATTGCATTCTCTTTGCTAA	0.478													21	48					4.35082e-09	5.20082e-09	1	1	0	A	66599214	C	A	66599214	3	1	48	1	0	0	0	0	1	0	0	0	4564	913	32	2	356	2	DIS3L	15	66599214	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	393046	66599214	35932178	3364	7758										
MAP2K5	5607	broad.mit.edu	37	chr15	68061960	68061960	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattcgcccgtccttccagtTggagagttctcggagccatt	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:68061960T>C	ENST00000178640.5	+	20	1782	c.1155T>C	c.(1153-1155)gtT>gtC	p.V385V	MAP2K5_ENST00000340972.4_Silent_p.V195V|MAP2K5_ENST00000354498.5_Silent_p.V349V|MAP2K5_ENST00000395476.2_Silent_p.V375V	NM_145160.2	NP_660143.1	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	385	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|skin(1)	16						TCCTTCCAGTTGGAGAGTTCT	0.453													4	28					0	0	1	0	0	C	68061960	T	C	68061960	2	2	48	1	0	0	0	0	0	0	0	1	9289	1799	63	4		4	MAP2K5	15	68061960	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1462746	68061960	34469432	3365	7759										
PIAS1	8554	broad.mit.edu	37	chr15	68378827	68378827	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcggttcccacagaaaatcAtgacgcctgcagacttgtcc	10	13	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:68378827A>G	ENST00000545237.1	+	3	955	c.214A>G	c.(214-216)Atg>Gtg	p.M72V	PIAS1_ENST00000249636.6_Missense_Mutation_p.M70V			O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	70					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)	24						ACAGAAAATCATGACGCCTGC	0.478													36	71					0	0	1	0	0	G	68378827	A	G	68378827	3	3	48	1	0	0	0	0	1	0	0	0	11922	217	8	4	214	4	PIAS1	15	68378827	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	316867	68378827	34152565	3366	7760										
FEM1B	10116	broad.mit.edu	37	chr15	68583077	68583077	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaccaaaacacagtgcagcGaagaagatcagtgcaaaatt	8	9	1	2	rs147988457		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:68583077G>A	ENST00000306917.4	+	2	1996	c.1381G>A	c.(1381-1383)Gaa>Aaa	p.E461K		NM_015322.3	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	461					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity	p.E461delE(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						ACAGTGCAGCGAAGAAGATCA	0.403													30	67					0	0	1	0	0	A	68583077	G	A	68583077	3	1	48	1	0	0	0	0	1	0	0	0	5842	1059	37	1	1387	1	FEM1B	15	68583077	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	204250	68583077	33948315	3367	7761										
ITGA11	22801	broad.mit.edu	37	chr15	68654041	68654041	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaccagagggggctgcagGcctggggagggcagtgcaga	21	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:68654041G>A	ENST00000423218.2	-	5	454	c.357_splice	c.e5-1	p.A120_splice	ITGA11_ENST00000562826.1_5'UTR|ITGA11_ENST00000315757.7_Splice_Site_p.A120_splice			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	120					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GGGGCTGCAGGCCTGGGGAGG	0.602													5	18					0	0	1	0	0	A	68654041	G	A	68654041	5	1	48	1	0	0	0	0	0	0	1	0	7917	1217	42	3	3311	3	ITGA11	15	68654041	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	70964	68654041	33877351	3368	7762										
ANP32A	8125	broad.mit.edu	37	chr15	69076874	69076874	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacacattttctcggtagtCgttcaggttggttacctcgc	10	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:69076874C>T	ENST00000465139.2	-	4	531	c.388G>A	c.(388-390)Gac>Aac	p.D130N	ANP32A_ENST00000560303.1_Missense_Mutation_p.D130N|ANP32A_ENST00000483551.2_5'UTR	NM_006305.3	NP_006296.1	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	130	LRRCT.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding			endometrium(1)|large_intestine(1)|lung(2)	4						TCTCGGTAGTCGTTCAGGTTG	0.483													36	48					0	0	1	0	0	T	69076874	C	T	69076874	3	4	48	1	0	0	0	0	1	0	0	0	699	884	31	1	377	1	ANP32A	15	69076874	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	422833	69076874	33454518	3369	7763										
SPESP1	246777	broad.mit.edu	37	chr15	69238254	69238254	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggtcgatcaaaccaaaCaatgtttccattgttttgca	6	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:69238254C>T	ENST00000310673.3	+	2	535	c.381C>T	c.(379-381)aaC>aaT	p.N127N	SPESP1_ENST00000560188.1_3'UTR|NOX5_ENST00000260364.5_Intron|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000448182.3_Intron|NOX5_ENST00000455873.3_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	127					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						TCAAACCAAACAATGTTTCCA	0.443													17	38					0	0	1	0	0	T	69238254	C	T	69238254	2	4	48	1	0	0	0	0	0	0	0	1	15095	477	17	3		3	SPESP1	15	69238254	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	161380	69238254	33293138	3370	7764										
SPESP1	246777	broad.mit.edu	37	chr15	69238515	69238515	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagaaaaacccgaagagttTggaaagcacccagagagttg	11	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:69238515T>G	ENST00000310673.3	+	2	796	c.642T>G	c.(640-642)ttT>ttG	p.F214L	NOX5_ENST00000260364.5_Intron|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000448182.3_Intron|NOX5_ENST00000455873.3_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	214					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						CCGAAGAGTTTGGAAAGCACC	0.403													47	67					0	0	1	0	0	G	69238515	T	G	69238515	3	3	48	1	0	0	0	0	1	0	0	0	15095	1809	63	4	648	4	SPESP1	15	69238515	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	261	69238515	33292877	3371	7765										
KIF23	9493	broad.mit.edu	37	chr15	69715499	69715499	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaacttttctttttttagaCgacaagtagatccagagttt	7	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:69715499C>T	ENST00000260363.4	+	7	682	c.563_splice	c.e7-1	p.R189_splice	KIF23_ENST00000352331.4_Splice_Site_p.R189_splice|KIF23_ENST00000559279.1_Splice_Site_p.R189_splice|KIF23_ENST00000537891.1_5'UTR|KIF23_ENST00000558585.1_5'UTR|KIF23_ENST00000395392.2_Splice_Site_p.R189_splice	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	189	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						TTTTTTTAGACGACAAGTAGA	0.373													12	30					0	0	1	0	0	T	69715499	C	T	69715499	5	4	48	1	0	0	0	0	0	0	1	0	8332	550	19	1	591	1	KIF23	15	69715499	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	476984	69715499	32815893	3372	7766										
UACA	55075	broad.mit.edu	37	chr15	70960671	70960671	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtcattttccagtagcaaTttctccatttccaacttctt	3	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:70960671T>A	ENST00000322954.6	-	16	2537	c.2352A>T	c.(2350-2352)aaA>aaT	p.K784N	UACA_ENST00000539319.1_Missense_Mutation_p.K675N|UACA_ENST00000560441.1_Missense_Mutation_p.K769N|UACA_ENST00000379983.2_Missense_Mutation_p.K771N	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	784						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						CCAGTAGCAATTTCTCCATTT	0.328													7	21					0	0	1	0	0	A	70960671	T	A	70960671	3	1	48	1	0	0	0	0	1	0	0	0	16884	1490	52	4	1914	4	UACA	15	70960671	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1245172	70960671	31570721	3373	7767										
MYO9A	4649	broad.mit.edu	37	chr15	72190380	72190380	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtttagcttttctaacttCttaagcacaggattagaaga	8	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:72190380C>A	ENST00000356056.5	-	25	4936	c.4464G>T	c.(4462-4464)aaG>aaT	p.K1488N	MYO9A_ENST00000564571.1_Missense_Mutation_p.K1488N|MYO9A_ENST00000444904.1_Missense_Mutation_p.K1469N|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000424560.1_Missense_Mutation_p.K1488N|MYO9A_ENST00000566885.1_Missense_Mutation_p.K1108N	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1488	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTTCTAACTTCTTAAGCACAG	0.378													16	42					6.94344e-10	8.4399e-10	1	1	0	A	72190380	C	A	72190380	3	1	48	1	0	0	0	0	1	0	0	0	10131	912	32	2	3254	2	MYO9A	15	72190380	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1229709	72190380	30341012	3374	7768										
ARIH1	25820	broad.mit.edu	37	chr15	72855808	72855808	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtccaatatcctgatgctaAacctgttcgctgcaaatgtg	8	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:72855808A>G	ENST00000379887.4	+	7	1192	c.878A>G	c.(877-879)aAa>aGa	p.K293R		NM_005744.3	NP_005735.2	Q9Y4X5	ARI1_HUMAN	ariadne RBR E3 ubiquitin protein ligase 1	293					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	14						CCTGATGCTAAACCTGTTCGC	0.393													11	44					0	0	1	0	0	G	72855808	A	G	72855808	3	3	48	1	0	0	0	0	1	0	0	0	920	14	1	4	904	4	ARIH1	15	72855808	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	665428	72855808	29675584	3375	7769										
ADPGK	83440	broad.mit.edu	37	chr15	73045231	73045231	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggaagtcaccgcgggaaaGacctgctaacaaaaacaaca	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:73045231G>A	ENST00000311669.8	-	7	1035	c.942C>T	c.(940-942)gtC>gtT	p.V314V	ADPGK_ENST00000456471.2_Silent_p.V40V	NM_031284.4	NP_112574.3	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	315	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)	7						CCGCGGGAAAGACCTGCTAAC	0.483													22	24					0	0	1	0	0	A	73045231	G	A	73045231	2	1	48	1	0	0	0	0	0	0	0	1	329	929	33	3		3	ADPGK	15	73045231	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	189423	73045231	29486161	3376	7770										
NEO1	4756	broad.mit.edu	37	chr15	73470720	73470720	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcagtgcattgctgaaaatGatgttggaaatgcacaagct	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:73470720G>T	ENST00000339362.5	+	8	1690	c.1243G>T	c.(1243-1245)Gat>Tat	p.D415Y	NEO1_ENST00000261908.6_Missense_Mutation_p.D415Y|NEO1_ENST00000558964.1_Missense_Mutation_p.D415Y|NEO1_ENST00000560262.1_Missense_Mutation_p.D415Y			Q92859	NEO1_HUMAN	neogenin 1	415	Ig-like C2-type 4.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						TGCTGAAAATGATGTTGGAAA	0.383													5	18					0.014758	0.015099	1	1	0	T	73470720	G	T	73470720	3	4	48	1	0	0	0	0	1	0	0	0	10382	1290	45	2	1269	2	NEO1	15	73470720	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	425489	73470720	29060672	3377	7771										
NEO1	4756	broad.mit.edu	37	chr15	73566199	73566199	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatgcagagatacatgacTgggttattgagcctgttgtg	13	5	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:73566199T>C	ENST00000339362.5	+	21	3460	c.3013T>C	c.(3013-3015)Tgg>Cgg	p.W1005R	NEO1_ENST00000261908.6_Missense_Mutation_p.W1005R|NEO1_ENST00000558964.1_Missense_Mutation_p.W1005R|NEO1_ENST00000560262.1_Missense_Mutation_p.W1005R			Q92859	NEO1_HUMAN	neogenin 1	1005	Fibronectin type-III 6.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						GATACATGACTGGGTTATTGA	0.403													18	41					0	0	1	0	0	C	73566199	T	C	73566199	3	2	48	1	0	0	0	0	1	0	0	0	10382	1580	55	4	3091	4	NEO1	15	73566199	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	95479	73566199	28965193	3378	7772										
TBC1D21	161514	broad.mit.edu	37	chr15	74174038	74174038	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattcctcacgggctacttCtcatggcagagttcccagga	9	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:74174038C>A	ENST00000300504.2	+	3	305	c.222C>A	c.(220-222)ttC>ttA	p.F74L	TBC1D21_ENST00000535547.2_Missense_Mutation_p.F38L|TBC1D21_ENST00000562056.1_Missense_Mutation_p.F74L	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	74	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						CGGGCTACTTCTCATGGCAGA	0.617													21	44					1.96292e-10	2.40731e-10	1	1	0	A	74174038	C	A	74174038	3	1	48	1	0	0	0	0	1	0	0	0	15666	912	32	2	232	2	TBC1D21	15	74174038	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	607839	74174038	28357354	3379	7773										
C15orf27	123591	broad.mit.edu	37	chr15	76462186	76462186	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggattgtggtgcttgggatCtgggattacatcgaaaacaa	13	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:76462186C>A	ENST00000388942.3	+	6	762	c.486C>A	c.(484-486)atC>atA	p.I162I		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	162						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						TGCTTGGGATCTGGGATTACA	0.498													86	152					5.56898e-48	8.07487e-48	1	1	0	A	76462186	C	A	76462186	2	1	48	1	0	0	0	0	0	0	0	1	1794	903	32	2		2	C15orf27	15	76462186	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2288148	76462186	26069206	3380	7774										
PSTPIP1	9051	broad.mit.edu	37	chr15	77329411	77329411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgagctggacctgtccgCgggagacatcctggaggtga	16	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:77329411C>T	ENST00000558012.1	+	15	1634	c.1145C>T	c.(1144-1146)gCg>gTg	p.A382V	PSTPIP1_ENST00000559295.1_Missense_Mutation_p.A363V|PSTPIP1_ENST00000267939.5_Missense_Mutation_p.A362V|PSTPIP1_ENST00000557995.1_3'UTR|PSTPIP1_ENST00000379595.3_Missense_Mutation_p.A379V	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	382	SH3.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						GACCTGTCCGCGGGAGACATC	0.627													19	42					0	0	1	0	0	T	77329411	C	T	77329411	3	4	48	1	0	0	0	0	1	0	0	0	12769	768	27	1	1203	1	PSTPIP1	15	77329411	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	867225	77329411	25201981	3381	7775										
DNAJA4	55466	broad.mit.edu	37	chr15	78557106	78557106	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccccccccgcagacacaagAtggtgaaggagacccagtac	11	15	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:78557106A>C	ENST00000394855.3	+	2	316	c.88A>C	c.(88-90)Atg>Ctg	p.M30L	DNAJA4_ENST00000394852.3_Start_Codon_SNP_p.M1L|DNAJA4_ENST00000343789.3_Start_Codon_SNP_p.M1L|DNAJA4_ENST00000489435.2_Missense_Mutation_p.M30L	NM_018602.3	NP_061072.3	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	1	J.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	8						CAGACACAAGATGGTGAAGGA	0.721													8	21					0	0	1	0	0	C	78557106	A	C	78557106	3	2	48	1	0	0	0	0	1	0	0	0	4641	333	12	4	94	4	DNAJA4	15	78557106	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1227695	78557106	23974286	3382	7776										
CRABP1	1381	broad.mit.edu	37	chr15	78633519	78633519	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagatcaacttcaaggtcGgagaaggctttgaggaggag	15	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:78633519G>A	ENST00000299529.6	+	2	310	c.205G>A	c.(205-207)Gga>Aga	p.G69R		NM_004378.2	NP_004369.1	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	69					multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity			breast(1)|lung(4)|skin(1)	6					Alitretinoin(DB00523)|Etretinate(DB00926)	CTTCAAGGTCGGAGAAGGCTT	0.637													5	14					0	0	1	0	0	A	78633519	G	A	78633519	3	1	48	1	0	0	0	0	1	0	0	0	3866	1117	39	1	211	1	CRABP1	15	78633519	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	76413	78633519	23897873	3383	7777										
PSMA4	5685	broad.mit.edu	37	chr15	78837280	78837280	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgctgtgtgatatcaaacaAgcttatacacaatttggagg	10	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:78837280A>C	ENST00000044462.7	+	6	507	c.357A>C	c.(355-357)caA>caC	p.Q119H	PSMA4_ENST00000560217.1_Missense_Mutation_p.Q88H|PSMA4_ENST00000559082.1_Missense_Mutation_p.Q119H|PSMA4_ENST00000558281.1_Missense_Mutation_p.Q119H|PSMA4_ENST00000558341.1_Intron|PSMA4_ENST00000558094.1_Missense_Mutation_p.Q31H|PSMA4_ENST00000557929.1_3'UTR|PSMA4_ENST00000413382.2_Missense_Mutation_p.Q48H	NM_002789.4	NP_002780.1	P25789	PSA4_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 4	119					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						ATATCAAACAAGCTTATACAC	0.313													11	18					0	0	1	0	0	C	78837280	A	C	78837280	3	2	48	1	0	0	0	0	1	0	0	0	12717	69	3	4	375	4	PSMA4	15	78837280	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	203761	78837280	23694112	3384	7778										
RASGRF1	5923	broad.mit.edu	37	chr15	79294116	79294116	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatctgactcctctctcatGgagacttctgagcctgggag	10	11	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:79294116G>T	ENST00000419573.3	-	17	2785	c.2511C>A	c.(2509-2511)tcC>tcA	p.S837S	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Silent_p.S821S|RASGRF1_ENST00000394745.3_Silent_p.S53S	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	839					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCTCTCTCATGGAGACTTCTG	0.284													20	39					9.7654e-05	0.000105618	1	1	0	T	79294116	G	T	79294116	2	4	48	1	0	0	0	0	0	0	0	1	13123	1335	47	5		5	RASGRF1	15	79294116	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	456836	79294116	23237276	3385	7779										
RASGRF1	5923	broad.mit.edu	37	chr15	79320125	79320125	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgtccaggaggatctcacAgccttcgatgatcatgcgct	12	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:79320125A>C	ENST00000419573.3	-	9	1613	c.1339T>G	c.(1339-1341)Tgt>Ggt	p.C447G	RASGRF1_ENST00000558480.2_Missense_Mutation_p.C447G|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	447					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						AGGATCTCACAGCCTTCGATG	0.577													5	109					0	0	1	0	0	C	79320125	A	C	79320125	3	2	48	1	0	0	0	0	1	0	0	0	13123	188	7	4	2562	4	RASGRF1	15	79320125	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	26009	79320125	23211267	3386	7780										
KIAA1024	23251	broad.mit.edu	37	chr15	79750509	79750509	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagtggctcccacggacccAaactagagaacaaccctgac	8	15	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:79750509A>G	ENST00000305428.3	+	2	2095	c.2020A>G	c.(2020-2022)Aaa>Gaa	p.K674E		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	674						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CCACGGACCCAAACTAGAGAA	0.557													7	247					0	0	1	0	0	G	79750509	A	G	79750509	3	3	48	1	0	0	0	0	1	0	0	0	8246	131	5	4	2022	4	KIAA1024	15	79750509	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	430384	79750509	22780883	3387	7781										
MTHFS	10588	broad.mit.edu	37	chr15	80137564	80137564	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccagatttaagctgttgaCgagtcttcgtaaaggacttc	9	8	1	2	rs150067777	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:80137564C>T	ENST00000258874.3	-	3	660	c.600G>A	c.(598-600)tcG>tcA	p.S200S	ST20-MTHFS_ENST00000479961.1_Silent_p.S176S	NM_006441.3	NP_006432.1	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	200					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding			endometrium(3)|large_intestine(1)|liver(1)	5				all cancers(203;0.00467)		AAGCTGTTGACGAGTCTTCGT	0.393													31	52					0	0	1	0	0	T	80137564	C	T	80137564	2	4	48	1	0	0	0	0	0	0	0	1	9979	523	19	1		1	MTHFS	15	80137564	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	387055	80137564	22393828	3388	7782										
MTHFS	10588	broad.mit.edu	37	chr15	80137599	80137599	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacttcatctaccttcatgtCgttttcattcactgggacct	6	12	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:80137599C>T	ENST00000258874.3	-	3	625	c.565G>A	c.(565-567)Gac>Aac	p.D189N	ST20-MTHFS_ENST00000479961.1_Missense_Mutation_p.D165N	NM_006441.3	NP_006432.1	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	189					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding	p.D189N(1)		endometrium(3)|large_intestine(1)|liver(1)	5				all cancers(203;0.00467)		ACCTTCATGTCGTTTTCATTC	0.433													13	78					0	0	1	0	0	T	80137599	C	T	80137599	3	4	48	1	0	0	0	0	1	0	0	0	9979	884	31	1	50	1	MTHFS	15	80137599	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	35	80137599	22393793	3389	7783										
IL16	3603	broad.mit.edu	37	chr15	81565534	81565534	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagcagcagccgatggaaGgctacaggaaggtaggcttc	15	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:81565534G>T	ENST00000394660.2	+	6	1139	c.779G>T	c.(778-780)aGg>aTg	p.R260M	IL16_ENST00000302987.4_Missense_Mutation_p.R260M	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	260	Interaction with GRIN2A.|PDZ 1.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GCCGATGGAAGGCTACAGGAA	0.517													16	35					1.15088e-07	1.32965e-07	1	1	0	T	81565534	G	T	81565534	3	4	48	1	0	0	0	0	1	0	0	0	7676	1000	35	5	797	5	IL16	15	81565534	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1427935	81565534	20965858	3390	7784										
IL16	3603	broad.mit.edu	37	chr15	81598795	81598795	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctgcacggtgacactggaGaagatgtcggcagggctggg	18	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:81598795G>T	ENST00000394660.2	+	18	4071	c.3711G>T	c.(3709-3711)gaG>gaT	p.E1237D	IL16_ENST00000302987.4_Missense_Mutation_p.E1238D|IL16_ENST00000394652.2_Missense_Mutation_p.E537D|RP11-761I4.4_ENST00000607019.1_RNA	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	1238	PDZ 4.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						TGACACTGGAGAAGATGTCGG	0.567													57	122					1.17673e-23	1.64719e-23	1	1	0	T	81598795	G	T	81598795	3	4	48	1	0	0	0	0	1	0	0	0	7676	933	33	2	3780	2	IL16	15	81598795	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	33261	81598795	20932597	3391	7785										
FAM154B	283726	broad.mit.edu	37	chr15	82575144	82575144	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccaacccatctggaaaatTtgatggtttgagcactttca	7	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:82575144T>G	ENST00000339465.5	+	3	1007	c.938T>G	c.(937-939)tTt>tGt	p.F313C	FAM154B_ENST00000427381.2_Missense_Mutation_p.F298C|FAM154B_ENST00000565501.1_3'UTR	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	313										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						TCTGGAAAATTTGATGGTTTG	0.393													25	39					0	0	1	0	0	G	82575144	T	G	82575144	3	3	48	1	0	0	0	0	1	0	0	0	5494	1841	64	4	948	4	FAM154B	15	82575144	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	976349	82575144	19956248	3392	7786										
BNC1	646	broad.mit.edu	37	chr15	83926268	83926268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgtgtctgtttcgactgcGaacagacgaaaacatggtgt	12	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:83926268G>A	ENST00000345382.2	-	5	2996	c.2911C>T	c.(2911-2913)Cgc>Tgc	p.R971C	BNC1_ENST00000569704.1_Missense_Mutation_p.R964C|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	971					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TTTCGACTGCGAACAGACGAA	0.507													47	88					0	0	1	0	0	A	83926268	G	A	83926268	3	1	48	1	0	0	0	0	1	0	0	0	1473	1058	37	1	77	1	BNC1	15	83926268	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1351124	83926268	18605124	3393	7787										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84558912	84558912	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatccgcttgaagagggtagTtcctgaccattattgtcact	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:84558912T>G	ENST00000286744.5	+	11	1348	c.1124T>G	c.(1123-1125)gTt>gGt	p.V375G	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.V375G	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	375						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAGAGGGTAGTTCCTGACCAT	0.403													15	96					0	0	1	0	0	G	84558912	T	G	84558912	3	3	48	1	0	0	0	0	1	0	0	0	275	1725	60	4	1162	4	ADAMTSL3	15	84558912	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	632644	84558912	17972480	3394	7788										
PDE8A	5151	broad.mit.edu	37	chr15	85664054	85664054	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagatccaattgatgaggtCgctgcactcatcgcagccac	9	12	1	3	rs149557632		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:85664054C>T	ENST00000310298.4	+	19	2013	c.1761C>T	c.(1759-1761)gtC>gtT	p.V587V	PDE8A_ENST00000339708.5_Silent_p.V541V|PDE8A_ENST00000394553.1_Silent_p.V587V|PDE8A_ENST00000557957.1_Silent_p.V515V			O60658	PDE8A_HUMAN	phosphodiesterase 8A	587	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity	p.V587V(1)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			TTGATGAGGTCGCTGCACTCA	0.448													24	48					0	0	1	0	0	T	85664054	C	T	85664054	2	4	48	1	0	0	0	0	0	0	0	1	11699	871	31	1		1	PDE8A	15	85664054	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1105142	85664054	16867338	3395	7789										
ISG20	3669	broad.mit.edu	37	chr15	89198710	89198710	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatggagctctatcaaatctCccagagaatccgagcccgcc	9	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:89198710C>T	ENST00000306072.5	+	4	852	c.494C>T	c.(493-495)tCc>tTc	p.S165F	ISG20_ENST00000560741.1_Missense_Mutation_p.S165F|ISG20_ENST00000560746.1_3'UTR	NM_002201.4	NP_002192.2	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease gene 20kDa	165					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity			large_intestine(1)|lung(3)|prostate(1)	5	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			TATCAAATCTCCCAGAGAATC	0.587													20	33					0	0	1	0	0	T	89198710	C	T	89198710	3	4	48	1	0	0	0	0	1	0	0	0	7897	855	30	3	504	3	ISG20	15	89198710	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3534656	89198710	13332682	3396	7790										
ACAN	176	broad.mit.edu	37	chr15	89401045	89401045	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacagccatcagggtttccTgacactagtggggaaacatc	12	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:89401045T>C	ENST00000439576.2	+	12	5603	c.5229T>C	c.(5227-5229)ccT>ccC	p.P1743P	ACAN_ENST00000352105.7_Silent_p.P1743P|ACAN_ENST00000559004.1_Silent_p.P1743P|ACAN_ENST00000561243.1_Silent_p.P1743P	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1743					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CAGGGTTTCCTGACACTAGTG	0.512													52	99					0	0	1	0	0	C	89401045	T	C	89401045	2	2	48	1	0	0	0	0	0	0	0	1	117	1567	55	4		4	ACAN	15	89401045	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	202335	89401045	13130347	3397	7791										
FANCI	55215	broad.mit.edu	37	chr15	89817466	89817466	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaactcctccaaggctcaaAatttcttcagaatctagttc	4	12	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:89817466A>C	ENST00000310775.7	+	12	1129	c.1043A>C	c.(1042-1044)aAa>aCa	p.K348T	FANCI_ENST00000300027.8_Missense_Mutation_p.K348T	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	348					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					CAAGGCTCAAAATTTCTTCAG	0.328								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				7	9					0	0	1	0	0	C	89817466	A	C	89817466	3	2	48	1	0	0	0	0	1	0	0	0	5701	14	1	4	1085	4	FANCI	15	89817466	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	416421	89817466	12713926	3398	7792										
ANPEP	290	broad.mit.edu	37	chr15	90349269	90349269	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatctgccaactccccctcGaactcgctgtccatctcata	4	18	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:90349269G>A	ENST00000300060.6	-	2	859	c.546C>T	c.(544-546)ttC>ttT	p.F182F		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	182	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ACTCCCCCTCGAACTCGCTGT	0.607													10	107					0	0	1	0	0	A	90349269	G	A	90349269	2	1	48	1	0	0	0	0	0	0	0	1	704	1049	37	1		1	ANPEP	15	90349269	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	531803	90349269	12182123	3399	7793										
IDH2	3418	broad.mit.edu	37	chr15	90630471	90630471	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctcataccagatcttattCttgtcgaagtcggtcttata	7	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:90630471C>A	ENST00000330062.3	-	7	953	c.840G>T	c.(838-840)aaG>aaT	p.K280N	IDH2_ENST00000559482.1_Missense_Mutation_p.K171N|IDH2_ENST00000539790.1_Missense_Mutation_p.K150N|IDH2_ENST00000540499.2_Missense_Mutation_p.K228N	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	280					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding			biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			AGATCTTATTCTTGTCGAAGT	0.542			M		GBM						OREG0023466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	51					2.08457e-15	2.74702e-15	1	1	0	A	90630471	C	A	90630471	3	1	48	1	0	0	0	0	1	0	0	0	7538	912	32	2	538	2	IDH2	15	90630471	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	281202	90630471	11900921	3400	7794										
SV2B	9899	broad.mit.edu	37	chr15	91827259	91827259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctctccccagacctctacGagcacaagttcatcaactgt	5	15	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:91827259G>A	ENST00000394232.1	+	11	1986	c.1516G>A	c.(1516-1518)Gag>Aag	p.E506K	SV2B_ENST00000330276.4_Missense_Mutation_p.E506K|SV2B_ENST00000545111.2_Missense_Mutation_p.E355K	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	506					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			AGACCTCTACGAGCACAAGTT	0.512													73	147					0	0	1	0	0	A	91827259	G	A	91827259	3	1	48	1	0	0	0	0	1	0	0	0	15473	1059	37	1	1554	1	SV2B	15	91827259	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1196788	91827259	10704133	3401	7795										
ST8SIA2	8128	broad.mit.edu	37	chr15	92981795	92981795	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caactcgggggtcttgctgaAcagcggctgtgggcaggaga	17	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:92981795A>G	ENST00000268164.3	+	4	740	c.503A>G	c.(502-504)aAc>aGc	p.N168S	ST8SIA2_ENST00000539113.1_Missense_Mutation_p.N147S	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	168					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			GTCTTGCTGAACAGCGGCTGT	0.602													5	77					0	0	1	0	0	G	92981795	A	G	92981795	3	3	48	1	0	0	0	0	1	0	0	0	15287	43	2	4	517	4	ST8SIA2	15	92981795	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1154536	92981795	9549597	3402	7796										
IGF1R	3480	broad.mit.edu	37	chr15	99500656	99500656	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggccttgccgctgccccaGtcttcgacctgctgatcctt	10	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:99500656G>A	ENST00000268035.6	+	21	4700	c.4089G>A	c.(4087-4089)caG>caA	p.Q1363Q	IGF1R_ENST00000558762.1_Silent_p.Q1362Q|RP11-654A16.3_ENST00000559468.1_RNA	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	1363					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CGCTGCCCCAGTCTTCGACCT	0.622													23	41					0	0	1	0	0	A	99500656	G	A	99500656	2	1	48	1	0	0	0	0	0	0	0	1	7614	1020	36	3		3	IGF1R	15	99500656	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6518861	99500656	3030736	3403	7797										
SYNM	23336	broad.mit.edu	37	chr15	99672121	99672121	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaaagtccactgtccagaGaagtcatcttcctaggccct	8	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:99672121G>T	ENST00000336292.6	+	5	3673	c.3553G>T	c.(3553-3555)Gaa>Taa	p.E1185*	SYNM_ENST00000560674.1_Intron|SYNM_ENST00000328642.7_Intron|SYNM_ENST00000561323.1_3'UTR	NM_145728.2	NP_663780.2	O15061	SYNEM_HUMAN	synemin, intermediate filament protein	1186	Interaction with TLN1 and VCL.|Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(6)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	29						ACTGTCCAGAGAAGTCATCTT	0.627													16	25					1.5739e-10	1.93697e-10	1	1	0	T	99672121	G	T	99672121	4	4	48	1	0	0	0	0	0	1	0	0	15511	943	33	2	3569	2	SYNM	15	99672121	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	171465	99672121	2859271	3404	7798										
ALDH1A3	220	broad.mit.edu	37	chr15	101432738	101432738	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggagacgatggatacaggGaagccatttcttcatgcttt	11	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:101432738G>A	ENST00000329841.5	+	4	901	c.369G>A	c.(367-369)ggG>ggA	p.G123G	ALDH1A3_ENST00000346623.6_Intron	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	123					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	TGGATACAGGGAAGCCATTTC	0.463													45	78					0	0	1	0	0	A	101432738	G	A	101432738	2	1	48	1	0	0	0	0	0	0	0	1	489	1161	41	3		3	ALDH1A3	15	101432738	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1760617	101432738	1098654	3405	7799										
LRRK1	79705	broad.mit.edu	37	chr15	101464879	101464879	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccccagcatgtactggtgTgtggggccggaggagtcagc	16	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:101464879T>G	ENST00000388948.3	+	2	401	c.42T>G	c.(40-42)tgT>tgG	p.C14W	LRRK1_ENST00000532029.2_Missense_Mutation_p.C14W|LRRK1_ENST00000284395.5_5'UTR	NM_024652.3	NP_078928.3	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	14					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTACTGGTGTGTGGGGCCGG	0.602													12	81					0	0	1	0	0	G	101464879	T	G	101464879	3	3	48	1	0	0	0	0	1	0	0	0	9076	1702	59	4	44	4	LRRK1	15	101464879	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	32141	101464879	1066513	3406	7800										
SNRPA1	6627	broad.mit.edu	37	chr15	101832242	101832242	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatcaagtccctcacctatAcggctaaaataaaaatagag	6	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:101832242A>G	ENST00000254193.6	-	3	306	c.234T>C	c.(232-234)cgT>cgC	p.R78R	SNRPA1_ENST00000560856.1_5'UTR	NM_003090.2	NP_003081.2	P09661	RU2A_HUMAN	small nuclear ribonucleoprotein polypeptide A'	78						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCTCACCTATACGGCTAAAAT	0.388													56	91					0	0	1	0	0	G	101832242	A	G	101832242	2	3	48	1	0	0	0	0	0	0	0	1	14913	378	14	4		4	SNRPA1	15	101832242	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	367363	101832242	699150	3407	7801										
PCSK6	5046	broad.mit.edu	37	chr15	101938712	101938712	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcactgtaaatgtcgatgTagttgggtctgatgcccagc	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:101938712T>C	ENST00000348070.1	-	8	889	c.890A>G	c.(889-891)tAc>tGc	p.Y297C	PCSK6_ENST00000398181.2_Missense_Mutation_p.Y297C|PCSK6_ENST00000331826.7_Missense_Mutation_p.Y132C|PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000344273.2_Missense_Mutation_p.Y297C|PCSK6_ENST00000358417.3_Missense_Mutation_p.Y297C	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	298	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATGTCGATGTAGTTGGGTCT	0.607													46	63					0	0	1	0	0	C	101938712	T	C	101938712	3	2	48	1	0	0	0	0	1	0	0	0	11650	1638	57	4	2559	4	PCSK6	15	101938712	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	106470	101938712	592680	3408	7802										
OR4F15	390649	broad.mit.edu	37	chr15	102359228	102359228	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgatgcatttattactcCttttctgaatccagttatct	4	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr15:102359228C>A	ENST00000332238.4	+	1	863	c.839C>A	c.(838-840)cCt>cAt	p.P280H		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTTATTACTCCTTTTCTGAAT	0.388													20	33					2.39187e-15	3.14903e-15	1	1	0	A	102359228	C	A	102359228	3	1	48	1	0	0	0	0	1	0	0	0	11108	681	24	5	841	5	OR4F15	15	102359228	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	420516	102359228	172164	3409	7803										
MPG	4350	broad.mit.edu	37	chr16	129447	129447	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccgacggatggggcaaaaGaagcagcgaccagctagagc	15	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:129447G>T	ENST00000219431.4	+	3	294	c.63G>T	c.(61-63)aaG>aaT	p.K21N	MPG_ENST00000397817.1_Missense_Mutation_p.K4N|MPG_ENST00000475280.1_3'UTR	NM_002434.3	NP_002425.2	P29372	3MG_HUMAN	N-methylpurine-DNA glycosylase	21					depurination|DNA dealkylation involved in DNA repair	nucleoplasm	alkylbase DNA N-glycosylase activity|damaged DNA binding|identical protein binding			endometrium(4)|kidney(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9		all_cancers(16;9.01e-08)|all_epithelial(16;7.64e-07)|Hepatocellular(780;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				TGGGGCAAAAGAAGCAGCGAC	0.562								Base excision repair (BER), DNA glycosylases					20	57					1.2644e-06	1.4261e-06	1	1	0	T	129447	G	T	129447	3	4	48	1	0	0	0	0	1	0	0	0	9772	933	33	2	97	2	MPG	16	129447	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		129447	90225306	3410	7804										
C16orf11	146325	broad.mit.edu	37	chr16	613438	613438	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccccttcacctgcctggaGaagtcacacctctacaacca	6	17	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:613438G>T	ENST00000409413.3	+	2	423	c.144G>T	c.(142-144)gaG>gaT	p.E48D		NM_145270.2	NP_660313.1	P0CG20	CP011_HUMAN	chromosome 16 open reading frame 11	48										central_nervous_system(1)|endometrium(1)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10						CCTGCCTGGAGAAGTCACACC	0.612													33	88					2.48696e-23	3.47605e-23	1	1	0	T	613438	G	T	613438	3	4	48	1	0	0	0	0	1	0	0	0	1817	933	33	2	146	2	C16orf11	16	613438	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	483991	613438	89741315	3411	7805										
JMJD8	339123	broad.mit.edu	37	chr16	733859	733859	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacggacgggcacgcgctcAccgagttgtccgtgagtccc	15	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:733859A>G	ENST00000293882.4	-	3	435		c.e3+1		JMJD8_ENST00000454700.1_Splice_Site|JMJD8_ENST00000562824.1_Splice_Site|JMJD8_ENST00000562111.1_Splice_Site|JMJD8_ENST00000412368.2_Splice_Site			Q96S16	JMJD8_HUMAN	jumonji domain containing 8											breast(1)	1						GCACGCGCTCACCGAGTTGTC	0.731													4	8					0	0	1	0	0	G	733859	A	G	733859	5	3	48	1	0	0	0	0	0	0	1	0	7999	173	6	4	595	4	JMJD8	16	733859	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	120421	733859	89620894	3412	7806										
FBXL16	146330	broad.mit.edu	37	chr16	747067	747067	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctgggccagcacacacttCtcgcaggccgagaaatacca	9	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:747067C>A	ENST00000397621.1	-	2	670	c.339G>T	c.(337-339)gaG>gaT	p.E113D	FBXL16_ENST00000324361.5_Missense_Mutation_p.E113D	NM_153350.3	NP_699181.2	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	113	F-box.									endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)	10		Hepatocellular(780;0.0218)				GCACACACTTCTCGCAGGCCG	0.662													19	42					0.000175454	0.000188314	1	1	0	A	747067	C	A	747067	3	1	48	1	0	0	0	0	1	0	0	0	5744	912	32	2	1120	2	FBXL16	16	747067	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13208	747067	89607686	3413	7807										
PRR25	388199	broad.mit.edu	37	chr16	855733	855733	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaccagctcaggaacagcGcagccgctcgcaaatgcagt	10	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:855733G>A	ENST00000301698.1	+	1	291	c.291G>A	c.(289-291)gcG>gcA	p.A97A		NM_001013638.1	NP_001013660.1	Q96S07	PRR25_HUMAN	proline rich 25	97										large_intestine(1)|lung(1)|skin(1)	3						CAGGAACAGCGCAGCCGCTCG	0.647													11	22					0	0	1	0	0	A	855733	G	A	855733	2	1	48	1	0	0	0	0	0	0	0	1	12646	1074	38	1		1	PRR25	16	855733	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	108666	855733	89499020	3414	7808										
SSTR5	0	broad.mit.edu	37	chr16	1129540	1129540	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcctgtgctacctgctcatCgtggtgaaggtgagggcggc	16	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1129540C>T	ENST00000293897.4	+	1	760	c.672C>T	c.(670-672)atC>atT	p.I224I	SSTR5_ENST00000397547.2_Silent_p.I224I|SSTR5_ENST00000562758.1_Intron	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	224					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	ACCTGCTCATCGTGGTGAAGG	0.687													17	25					0	0	1	0	0	T	1129540	C	T	1129540	2	4	48	1	0	0	0	0	0	0	0	1	15256	874	31	1		1	SSTR5	16	1129540	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	273807	1129540	89225213	3415	7809										
CACNA1H	8912	broad.mit.edu	37	chr16	1255242	1255242	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggaacccgtacaacatcttCgacggcatcatcgtggtcat	9	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1255242C>T	ENST00000348261.5	+	11	2828	c.2580C>T	c.(2578-2580)ttC>ttT	p.F860F	CACNA1H_ENST00000565831.1_Silent_p.F860F|CACNA1H_ENST00000358590.4_Silent_p.F860F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	860					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACAACATCTTCGACGGCATCA	0.602													41	47					0	0	1	0	0	T	1255242	C	T	1255242	2	4	48	1	0	0	0	0	0	0	0	1	2563	883	31	1		1	CACNA1H	16	1255242	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	125702	1255242	89099511	3416	7810										
CACNA1H	8912	broad.mit.edu	37	chr16	1267977	1267977	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacgccaccttcagcaacttCggcatggccttcctcacgct	7	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1267977C>T	ENST00000348261.5	+	32	5630	c.5382C>T	c.(5380-5382)ttC>ttT	p.F1794F	CACNA1H_ENST00000565831.1_Silent_p.F1788F|CACNA1H_ENST00000358590.4_Silent_p.F1788F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1794					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCAGCAACTTCGGCATGGCCT	0.682													6	9					0	0	1	0	0	T	1267977	C	T	1267977	2	4	48	1	0	0	0	0	0	0	0	1	2563	883	31	1		1	CACNA1H	16	1267977	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12735	1267977	89086776	3417	7811										
CACNA1H	8912	broad.mit.edu	37	chr16	1270813	1270813	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgaccccagaatccagagCttcctcttcaggggccatag	10	13	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1270813C>A	ENST00000348261.5	+	35	7129	c.6881C>A	c.(6880-6882)gCt>gAt	p.A2294D	CACNA1H_ENST00000565831.1_Missense_Mutation_p.A2288D|CACNA1H_ENST00000358590.4_Missense_Mutation_p.A2288D	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2294					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GAATCCAGAGCTTCCTCTTCA	0.632													33	77					7.61165e-28	1.08027e-27	1	1	0	A	1270813	C	A	1270813	3	1	48	1	0	0	0	0	1	0	0	0	2563	797	28	5	7015	5	CACNA1H	16	1270813	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2836	1270813	89083940	3418	7812										
CACNA1H	8912	broad.mit.edu	37	chr16	1270889	1270889	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccgtcggtgaccccccagaGaagaggcgggggctgtacct	15	14	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1270889G>T	ENST00000348261.5	+	35	7205	c.6957G>T	c.(6955-6957)gaG>gaT	p.E2319D	CACNA1H_ENST00000565831.1_Missense_Mutation_p.E2313D|CACNA1H_ENST00000358590.4_Missense_Mutation_p.E2313D	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2319					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACCCCCCAGAGAAGAGGCGGG	0.652													30	60					1.39806e-14	1.82523e-14	1	1	0	T	1270889	G	T	1270889	3	4	48	1	0	0	0	0	1	0	0	0	2563	933	33	2	7091	2	CACNA1H	16	1270889	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	76	1270889	89083864	3419	7813										
BAIAP3	8938	broad.mit.edu	37	chr16	1394064	1394064	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttccgccttctctgagttCgggctgcagctgctgcgcca	11	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1394064C>T	ENST00000324385.5	+	16	1691	c.1533C>T	c.(1531-1533)ttC>ttT	p.F511F	BAIAP3_ENST00000568887.1_Silent_p.F448F|BAIAP3_ENST00000562208.1_Silent_p.F453F|BAIAP3_ENST00000421665.2_Silent_p.F440F|BAIAP3_ENST00000397488.2_Silent_p.F493F|BAIAP3_ENST00000397489.1_Silent_p.F493F|BAIAP3_ENST00000426824.3_Silent_p.F476F	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	511					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				TCTCTGAGTTCGGGCTGCAGC	0.657													18	37					0	0	1	0	0	T	1394064	C	T	1394064	2	4	48	1	0	0	0	0	0	0	0	1	1302	883	31	1		1	BAIAP3	16	1394064	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	123175	1394064	88960689	3420	7814										
CLCN7	1186	broad.mit.edu	37	chr16	1510831	1510831	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggatactgcccttgatgaccCtgtacttgaggccagccagg	12	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:1510831C>T	ENST00000382745.4	-	5	1075	c.470G>A	c.(469-471)aGg>aAg	p.R157K	CLCN7_ENST00000448525.1_Missense_Mutation_p.R133K|CLCN7_ENST00000262318.8_Missense_Mutation_p.R133K	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	157						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				CTTGATGACCCTGTACTTGAG	0.637													15	41					0	0	1	0	0	T	1510831	C	T	1510831	3	4	48	1	0	0	0	0	1	0	0	0	3491	681	24	3	2031	3	CLCN7	16	1510831	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	116767	1510831	88843922	3421	7815										
ABCA3	21	broad.mit.edu	37	chr16	2354003	2354003	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccagggctgaggcacgccGaactgccctgggaagacggc	15	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:2354003G>A	ENST00000301732.5	-	12	2134	c.1434C>T	c.(1432-1434)ttC>ttT	p.F478F	ABCA3_ENST00000382381.3_Silent_p.F420F	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	478					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				GAGGCACGCCGAACTGCCCTG	0.607													57	77					0	0	1	0	0	A	2354003	G	A	2354003	2	1	48	1	0	0	0	0	0	0	0	1	33	1049	37	1		1	ABCA3	16	2354003	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	843172	2354003	88000750	3422	7816										
ZNF174	7727	broad.mit.edu	37	chr16	3454597	3454597	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accggctgagcccccatcatTgggagaaatccccactcctc	8	17	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:3454597T>C	ENST00000268655.4	+	2	1159	c.574T>C	c.(574-576)Tgg>Cgg	p.W192R	LA16c-306E5.2_ENST00000575785.1_RNA|ZNF174_ENST00000344823.5_Missense_Mutation_p.W192R|ZNF174_ENST00000572544.1_Missense_Mutation_p.W192R|ZNF174_ENST00000571936.1_Missense_Mutation_p.W192R|ZNF174_ENST00000575752.1_Missense_Mutation_p.W192R	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	192					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						CCCCCATCATTGGGAGAAATC	0.552													39	82					0	0	1	0	0	C	3454597	T	C	3454597	3	2	48	1	0	0	0	0	1	0	0	0	17801	1812	63	4	580	4	ZNF174	16	3454597	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1100594	3454597	86900156	3423	7817										
CREBBP	1387	broad.mit.edu	37	chr16	3781414	3781414	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgagcagggggtcggggtCgacgatggggggcagggtgt	24	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:3781414C>T	ENST00000262367.5	-	30	5760	c.4951G>A	c.(4951-4953)Gac>Aac	p.D1651N	CREBBP_ENST00000382070.3_Missense_Mutation_p.D1613N	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1651	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1651N(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGGTCGGGGTCGACGATGGGG	0.632			"T, N, F, Mis, O"	"MLL, MORF, RUNXBP2"	"ALL, AML, DLBCL, B-NHL "		Rubinstein-Taybi syndrome						3	17					0	0	1	0	0	T	3781414	C	T	3781414	3	4	48	1	0	0	0	0	1	0	0	0	3884	884	31	1	2385	1	CREBBP	16	3781414	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	326817	3781414	86573339	3424	7818										
CREBBP	1387	broad.mit.edu	37	chr16	3789684	3789684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcaaacagagctttggttCgatatgggaaagattcagac	11	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:3789684C>T	ENST00000262367.5	-	25	4984	c.4175G>A	c.(4174-4176)cGa>cAa	p.R1392Q	CREBBP_ENST00000382070.3_Missense_Mutation_p.R1354Q	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1392	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGCTTTGGTTCGATATGGGAA	0.473			"T, N, F, Mis, O"	"MLL, MORF, RUNXBP2"	"ALL, AML, DLBCL, B-NHL "		Rubinstein-Taybi syndrome						17	43					0	0	1	0	0	T	3789684	C	T	3789684	3	4	48	1	0	0	0	0	1	0	0	0	3884	884	31	1	3181	1	CREBBP	16	3789684	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8270	3789684	86565069	3425	7819										
CREBBP	1387	broad.mit.edu	37	chr16	3817823	3817823	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcacttcaggtttcttttCatccacttccattggttctg	5	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:3817823C>A	ENST00000262367.5	-	16	3957	c.3148G>T	c.(3148-3150)Gaa>Taa	p.E1050*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.E1012*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1050					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGTTTCTTTTCATCCACTTCC	0.433			"T, N, F, Mis, O"	"MLL, MORF, RUNXBP2"	"ALL, AML, DLBCL, B-NHL "		Rubinstein-Taybi syndrome						35	56					2.20262e-25	3.10409e-25	1	1	0	A	3817823	C	A	3817823	4	1	48	1	0	0	0	0	0	1	0	0	3884	835	29	2	4244	2	CREBBP	16	3817823	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	28139	3817823	86536930	3426	7820										
MGRN1	0	broad.mit.edu	37	chr16	4707338	4707338	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctgccctccttcaagattGacttctcggaatggaaggat	9	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:4707338G>T	ENST00000399577.5	+	5	628	c.535G>T	c.(535-537)Gac>Tac	p.D179Y	MGRN1_ENST00000415496.1_Missense_Mutation_p.D179Y|MGRN1_ENST00000262370.7_Missense_Mutation_p.D179Y|MGRN1_ENST00000586183.1_Missense_Mutation_p.D179Y|MGRN1_ENST00000588994.1_Missense_Mutation_p.D179Y	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	179					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CTTCAAGATTGACTTCTCGGA	0.602													29	40					2.12542e-12	2.68024e-12	1	1	0	T	4707338	G	T	4707338	3	4	48	1	0	0	0	0	1	0	0	0	9607	1290	45	2	553	2	MGRN1	16	4707338	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	889515	4707338	85647415	3427	7821										
C16orf71	146562	broad.mit.edu	37	chr16	4794991	4794991	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgacactccccaggacaccaAagaggcagattcaggaagca	10	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:4794991A>G	ENST00000299320.5	+	6	1500	c.1022A>G	c.(1021-1023)aAa>aGa	p.K341R	C16orf71_ENST00000590191.1_Missense_Mutation_p.K355R|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	341										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						CAGGACACCAAAGAGGCAGAT	0.602													5	70					0	0	1	0	0	G	4794991	A	G	4794991	3	3	48	1	0	0	0	0	1	0	0	0	1837	14	1	4	1040	4	C16orf71	16	4794991	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	87653	4794991	85559762	3428	7822										
UBN1	29855	broad.mit.edu	37	chr16	4908061	4908061	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtagaggcccttgcccgaaAatttgaagaaaaatacgtaa	9	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:4908061A>C	ENST00000396658.4	+	2	1023	c.320A>C	c.(319-321)aAa>aCa	p.K107T	UBN1_ENST00000590769.1_Missense_Mutation_p.K107T|UBN1_ENST00000262376.6_Missense_Mutation_p.K107T|UBN1_ENST00000545171.1_Missense_Mutation_p.K107T	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	107	Sufficient for interaction with HIRA.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						CTTGCCCGAAAATTTGAAGAA	0.378													22	53					0	0	1	0	0	C	4908061	A	C	4908061	3	2	48	1	0	0	0	0	1	0	0	0	16952	14	1	4	326	4	UBN1	16	4908061	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	113070	4908061	85446692	3429	7823										
UBN1	29855	broad.mit.edu	37	chr16	4910743	4910743	+	Missense_Mutation	SNP	G	G	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcgttaaagagatgctaaaGaaatttcagaaagagaaaga							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:4910743G>T	ENST00000396658.4	+	6	1453	c.750G>T	c.(748-750)aaG>aaT	p.K250N	UBN1_ENST00000590769.1_Missense_Mutation_p.K250N|UBN1_ENST00000262376.6_Missense_Mutation_p.K250N|UBN1_ENST00000545171.1_Missense_Mutation_p.K250N	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	250	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						AGATGCTAAAGAAATTTCAGA	0.488													40	84					1.66425e-11	2.0722e-11	1	1	0	T	4910743	G	T	4910743	3	4	48	1	0	0	0	0	1	0	0	0	16952	933	33	2	772	2	UBN1	16	4910743	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2682	4910743	85444010	3430	7824	24	2								
UBN1	29855	broad.mit.edu	37	chr16	4910745	4910745	+	Missense_Mutation	SNP	A	A	C													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgttaaagagatgctaaagaAatttcagaaagagaaagagg							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:4910745A>C	ENST00000396658.4	+	6	1455	c.752A>C	c.(751-753)aAa>aCa	p.K251T	UBN1_ENST00000590769.1_Missense_Mutation_p.K251T|UBN1_ENST00000262376.6_Missense_Mutation_p.K251T|UBN1_ENST00000585857.1_Intron|UBN1_ENST00000545171.1_Missense_Mutation_p.K251T	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	251	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						ATGCTAAAGAAATTTCAGAAA	0.483													49	72					0	0	1	0	0	C	4910745	A	C	4910745	3	2	48	1	0	0	0	0	1	0	0	0	16952	14	1	4	774	4	UBN1	16	4910745	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2	4910745	85444008	3431	7825	24	2								
C16orf89	146556	broad.mit.edu	37	chr16	5115773	5115773	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgttctaggaagacggtgGctctctccagcgcagacagg	13	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:5115773G>A	ENST00000315997.5	-	1	338	c.137C>T	c.(136-138)gCc>gTc	p.A46V	ALG1_ENST00000588623.1_Intron|C16orf89_ENST00000422873.1_Missense_Mutation_p.A84V|C16orf89_ENST00000474471.3_Missense_Mutation_p.A46V|C16orf89_ENST00000350219.4_Missense_Mutation_p.A84V|C16orf89_ENST00000472572.3_Missense_Mutation_p.A46V	NM_152459.4	NP_689672.4	Q6UX73	CP089_HUMAN	chromosome 16 open reading frame 89	46						extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	12						GAAGACGGTGGCTCTCTCCAG	0.587													26	43					0	0	1	0	0	A	5115773	G	A	5115773	3	1	48	1	0	0	0	0	1	0	0	0	1849	1203	42	3	1238	3	C16orf89	16	5115773	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	205028	5115773	85238980	3432	7826										
TMEM186	25880	broad.mit.edu	37	chr16	8890295	8890295	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatccagaatttctcagtCtctgcgtttggtagtttctc	7	10	3	1	rs145897590		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:8890295C>A	ENST00000333050.6	-	2	189	c.156G>T	c.(154-156)gaG>gaT	p.E52D	TMEM186_ENST00000564869.1_Intron|PMM2_ENST00000566983.1_Intron	NM_015421.3	NP_056236.2	Q96B77	TM186_HUMAN	transmembrane protein 186	52						integral to membrane|mitochondrion				NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9						ATTTCTCAGTCTCTGCGTTTG	0.537													37	71					3.09479e-21	4.27043e-21	1	1	0	A	8890295	C	A	8890295	3	1	48	1	0	0	0	0	1	0	0	0	16167	912	32	2	489	2	TMEM186	16	8890295	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3774522	8890295	81464458	3433	7827										
USP7	7874	broad.mit.edu	37	chr16	8989562	8989562	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatagttcatcttcttgatgAacaccaatgattttgtagct	6	7	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:8989562A>C	ENST00000344836.4	-	27	3054	c.2856T>G	c.(2854-2856)gtT>gtG	p.V952V	USP7_ENST00000535863.1_Silent_p.V853V|USP7_ENST00000381886.4_Silent_p.V936V	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	952					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						CTTCTTGATGAACACCAATGA	0.363													7	22					0	0	1	0	0	C	8989562	A	C	8989562	2	2	48	1	0	0	0	0	0	0	0	1	17147	233	9	4		4	USP7	16	8989562	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	99267	8989562	81365191	3434	7828										
GRIN2A	0	broad.mit.edu	37	chr16	10274037	10274037	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgatgaggctcttggggtCggtgcggttcatcagcagag	17	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:10274037C>T	ENST00000396573.2	-	3	541	c.232G>A	c.(232-234)Gac>Aac	p.D78N	GRIN2A_ENST00000404927.2_Missense_Mutation_p.D78N|GRIN2A_ENST00000396575.2_Missense_Mutation_p.D78N|GRIN2A_ENST00000330684.3_Missense_Mutation_p.D78N|GRIN2A_ENST00000562109.1_Missense_Mutation_p.D78N	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	78					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCTTGGGGTCGGTGCGGTTC	0.667													46	95					0	0	1	0	0	T	10274037	C	T	10274037	3	4	48	1	0	0	0	0	1	0	0	0	6819	884	31	1	4210	1	GRIN2A	16	10274037	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1284475	10274037	80080716	3435	7829										
ATF7IP2	80063	broad.mit.edu	37	chr16	10534236	10534236	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaggcaaaaatagcaaaaCttcaaagacgtattaaaaca	5	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:10534236C>A	ENST00000396560.2	+	6	1338	c.1111C>A	c.(1111-1113)Ctt>Att	p.L371I	ATF7IP2_ENST00000324570.5_Missense_Mutation_p.L371I|ATF7IP2_ENST00000356427.2_Missense_Mutation_p.L371I|ATF7IP2_ENST00000396559.1_Missense_Mutation_p.L371I|ATF7IP2_ENST00000543967.1_Intron	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						AATAGCAAAACTTCAAAGACG	0.294													5	12					0.217242	0.218251	1	1	0	A	10534236	C	A	10534236	3	1	48	1	0	0	0	0	1	0	0	0	1087	565	20	5	1125	5	ATF7IP2	16	10534236	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	260199	10534236	79820517	3436	7830										
ERCC4	2072	broad.mit.edu	37	chr16	14029408	14029408	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttgatgtaaatttgtcatCggatgctgctttcggaatcc	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:14029408C>T	ENST00000311895.7	+	8	1628	c.1619C>T	c.(1618-1620)tCg>tTg	p.S540L	CTD-2135D7.2_ENST00000570663.1_RNA|CTD-2135D7.2_ENST00000575137.1_RNA	NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	540					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						AATTTGTCATCGGATGCTGCT	0.468			"Mis, N, F"			"skin basal cell, skin squamous cell, melanoma"		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				30	56					0	0	1	0	0	T	14029408	C	T	14029408	3	4	48	1	0	0	0	0	1	0	0	0	5243	893	31	1	1649	1	ERCC4	16	14029408	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3495172	14029408	76325345	3437	7831										
BFAR	51283	broad.mit.edu	37	chr16	14761493	14761493	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttctcttcttgtttcaggAccgtgcctcagaggatgtgg	11	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:14761493A>G	ENST00000261658.2	+	8	1439	c.1160_splice	c.e8-1	p.T388_splice	BFAR_ENST00000563082.1_3'UTR|BFAR_ENST00000563971.1_Splice_Site_p.T263_splice|BFAR_ENST00000426842.2_Splice_Site_p.T260_splice	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	388					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						TTGTTTCAGGACCGTGCCTCA	0.557													28	65					0	0	1	0	0	G	14761493	A	G	14761493	5	3	48	1	0	0	0	0	0	0	1	0	1413	289	10	4	1188	4	BFAR	16	14761493	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	732085	14761493	75593260	3438	7832										
KIAA0430	9665	broad.mit.edu	37	chr16	15710987	15710987	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtcttcaaagaaagaatcAcaaaaggaatcttgtaagag	8	5	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:15710987A>G	ENST00000396368.3	-	15	3205	c.2999T>C	c.(2998-3000)gTg>gCg	p.V1000A	KIAA0430_ENST00000540441.2_Missense_Mutation_p.V835A|KIAA0430_ENST00000551742.1_Missense_Mutation_p.V1000A|KIAA0430_ENST00000548025.1_Missense_Mutation_p.V997A|KIAA0430_ENST00000602337.1_Missense_Mutation_p.V997A|KIAA0430_ENST00000344181.3_Intron	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	999						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						AGAAAGAATCACAAAAGGAAT	0.453													12	69					0	0	1	0	0	G	15710987	A	G	15710987	3	3	48	1	0	0	0	0	1	0	0	0	8218	159	6	4	2281	4	KIAA0430	16	15710987	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	949494	15710987	74643766	3439	7833										
MYH11	4629	broad.mit.edu	37	chr16	15833968	15833968	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatcctccagtttcttgatCttggcctcagccgtgacctt	7	14	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:15833968C>A	ENST00000338282.6	-	23	3043	c.2937G>T	c.(2935-2937)aaG>aaT	p.K979N	MYH11_ENST00000300036.5_Missense_Mutation_p.K979N|MYH11_ENST00000396324.3_Missense_Mutation_p.K986N|MYH11_ENST00000576790.1_Missense_Mutation_p.K979N|MYH11_ENST00000452625.2_Missense_Mutation_p.K986N	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	979					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle	p.K979N(1)		NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GTTTCTTGATCTTGGCCTCAG	0.507			T	CBFB	AML								37	75					9.85521e-28	1.39762e-27	1	1	0	A	15833968	C	A	15833968	3	1	48	1	0	0	0	0	1	0	0	0	10078	912	32	2	3092	2	MYH11	16	15833968	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	122981	15833968	74520785	3440	7834										
ABCC1	4363	broad.mit.edu	37	chr16	16108405	16108405	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggagttcagtcttcagggAtcatgctcactttctggctg	12	9	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:16108405A>G	ENST00000399408.2	+	4	584	c.409A>G	c.(409-411)Atc>Gtc	p.I137V	ABCC1_ENST00000346370.5_Missense_Mutation_p.I137V|ABCC1_ENST00000399410.3_Missense_Mutation_p.I137V|ABCC1_ENST00000351154.5_Missense_Mutation_p.I137V|ABCC1_ENST00000349029.5_Missense_Mutation_p.I137V|ABCC1_ENST00000345148.5_Missense_Mutation_p.I137V			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	137					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCTTCAGGGATCATGCTCAC	0.473													15	35					0	0	1	0	0	G	16108405	A	G	16108405	3	3	48	1	0	0	0	0	1	0	0	0	49	333	12	4	423	4	ABCC1	16	16108405	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	274437	16108405	74246348	3441	7835										
XYLT1	64131	broad.mit.edu	37	chr16	17202841	17202841	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgctccatgtaggcattgCggaggggcccattgtgcagc	14	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:17202841C>T	ENST00000261381.6	-	12	2675	c.2591G>A	c.(2590-2592)cGc>cAc	p.R864H		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	864					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GTAGGCATTGCGGAGGGGCCC	0.567													20	42					0	0	1	0	0	T	17202841	C	T	17202841	3	4	48	1	0	0	0	0	1	0	0	0	17522	768	27	1	292	1	XYLT1	16	17202841	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1094436	17202841	73151912	3442	7836										
XYLT1	64131	broad.mit.edu	37	chr16	17353254	17353254	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcttttgagtcctgggtgcGaagttgctgttgtcgacatt	13	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:17353254G>A	ENST00000261381.6	-	3	588	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	168					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCCTGGGTGCGAAGTTGCTGT	0.498													45	69					0	0	1	0	0	A	17353254	G	A	17353254	2	1	48	1	0	0	0	0	0	0	0	1	17522	1049	37	1		1	XYLT1	16	17353254	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	150413	17353254	73001499	3443	7837										
SMG1	23049	broad.mit.edu	37	chr16	18823418	18823418	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgtgacatgacatcaggCtgagtcttctggccagtgtt	11	9	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:18823418C>T	ENST00000446231.2	-	61	11065	c.10653G>A	c.(10651-10653)caG>caA	p.Q3551Q	RP11-1035H13.2_ENST00000569096.1_RNA|SMG1_ENST00000389467.3_Silent_p.Q3552Q			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3551					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						TGACATCAGGCTGAGTCTTCT	0.483													16	39					0	0	1	0	0	T	18823418	C	T	18823418	2	4	48	1	0	0	0	0	0	0	0	1	14848	796	28	3		3	SMG1	16	18823418	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1470164	18823418	71531335	3444	7838										
C16orf62	57020	broad.mit.edu	37	chr16	19656250	19656250	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagaatgctgtcatatttGattaatggatttataaaaat	6	2	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:19656250G>T	ENST00000438132.3	+	23	2223	c.2175G>T	c.(2173-2175)ttG>ttT	p.L725F	C16orf62_ENST00000251143.5_Missense_Mutation_p.L636F|C16orf62_ENST00000448695.1_Missense_Mutation_p.L486F|C16orf62_ENST00000542263.1_Missense_Mutation_p.L658F|C16orf62_ENST00000417362.2_Missense_Mutation_p.L569F|C16orf62_ENST00000543152.1_Missense_Mutation_p.L385F	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	636						integral to membrane		p.L636F(1)|p.L725F(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						TGTCATATTTGATTAATGGAT	0.318													16	30					3.35478e-16	4.45534e-16	1	1	0	T	19656250	G	T	19656250	3	4	48	1	0	0	0	0	1	0	0	0	1832	1281	45	2	1998	2	C16orf62	16	19656250	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	832832	19656250	70698503	3445	7839										
C16orf62	57020	broad.mit.edu	37	chr16	19702791	19702791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaaaccctggccaaggacGaggtgggtgccctctgctgt	14	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:19702791G>A	ENST00000438132.3	+	29	2959	c.2911G>A	c.(2911-2913)Gag>Aag	p.E971K	C16orf62_ENST00000251143.5_Missense_Mutation_p.E882K|C16orf62_ENST00000448695.1_Missense_Mutation_p.E732K|C16orf62_ENST00000542263.1_Missense_Mutation_p.E878K|C16orf62_ENST00000417362.2_Missense_Mutation_p.E789K|C16orf62_ENST00000543152.1_Missense_Mutation_p.E631K	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	882						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						GGCCAAGGACGAGGTGGGTGC	0.537													9	15					0	0	1	0	0	A	19702791	G	A	19702791	3	1	48	1	0	0	0	0	1	0	0	0	1832	1059	37	1	2758	1	C16orf62	16	19702791	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	46541	19702791	70651962	3446	7840										
GPR139	124274	broad.mit.edu	37	chr16	20043162	20043162	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggggctacttgttatggaAaagttatgattggtgtagaa	13	3	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20043162A>G	ENST00000570682.1	-	2	1257	c.957T>C	c.(955-957)ttT>ttC	p.F319F		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	319						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						TTGTTATGGAAAAGTTATGAT	0.483													55	87					0	0	1	0	0	G	20043162	A	G	20043162	2	3	48	1	0	0	0	0	0	0	0	1	6687	11	1	4		4	GPR139	16	20043162	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	340371	20043162	70311591	3447	7841										
ACSM2A	123876	broad.mit.edu	37	chr16	20491925	20491925	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaagacagcagccaacattCgaggagacttttggctcctt	9	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20491925C>T	ENST00000573854.1	+	11	1426	c.1312C>T	c.(1312-1314)Cga>Tga	p.R438*	ACSM2A_ENST00000219054.6_Nonsense_Mutation_p.R438*|ACSM2A_ENST00000396104.2_Nonsense_Mutation_p.R438*|ACSM2A_ENST00000575690.1_Nonsense_Mutation_p.R438*|ACSM2A_ENST00000536134.1_Nonsense_Mutation_p.R210*|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000417235.2_Nonsense_Mutation_p.R359*	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	438					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AGCCAACATTCGAGGAGACTT	0.512													54	90					0	0	1	0	0	T	20491925	C	T	20491925	4	4	48	1	0	0	0	0	0	1	0	0	183	876	31	1	1350	1	ACSM2A	16	20491925	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	448763	20491925	69862828	3448	7842										
ACSM2A	123876	broad.mit.edu	37	chr16	20497922	20497922	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgtcttgaacctgcccaaGactgtcacagggaaaattca	8	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20497922G>T	ENST00000573854.1	+	14	1770	c.1656G>T	c.(1654-1656)aaG>aaT	p.K552N	ACSM2A_ENST00000219054.6_Missense_Mutation_p.K552N|ACSM2A_ENST00000396104.2_Missense_Mutation_p.K552N|ACSM2A_ENST00000575690.1_Missense_Mutation_p.K552N|ACSM2A_ENST00000536134.1_Missense_Mutation_p.K324N|ACSM2A_ENST00000417235.2_Missense_Mutation_p.K473N	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	552					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						ACCTGCCCAAGACTGTCACAG	0.468													18	159					8.34094e-07	9.42356e-07	1	1	0	T	20497922	G	T	20497922	3	4	48	1	0	0	0	0	1	0	0	0	183	933	33	2	1706	2	ACSM2A	16	20497922	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5997	20497922	69856831	3449	7843										
ACSM2B	348158	broad.mit.edu	37	chr16	20554554	20554554	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggagccaaaagtctcctcGaatgttggctgctgtcttgt	11	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20554554G>A	ENST00000329697.6	-	11	1480	c.1312C>T	c.(1312-1314)Cga>Tga	p.R438*	ACSM2B_ENST00000565322.1_Nonsense_Mutation_p.R359*|ACSM2B_ENST00000567001.1_Nonsense_Mutation_p.R438*|ACSM2B_ENST00000565232.1_Nonsense_Mutation_p.R438*	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	438					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						AAGTCTCCTCGAATGTTGGCT	0.512													8	179					0	0	1	0	0	A	20554554	G	A	20554554	4	1	48	1	0	0	0	0	0	1	0	0	184	1066	37	1	437	1	ACSM2B	16	20554554	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	56632	20554554	69800199	3450	7844										
ACSM1	116285	broad.mit.edu	37	chr16	20682930	20682930	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcctgtggtcccactggtGaagaagatgaccattgggtc	13	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20682930G>A	ENST00000307493.4	-	4	742	c.675C>T	c.(673-675)ttC>ttT	p.F225F	ACSM1_ENST00000520010.1_Silent_p.F225F|ACSM1_ENST00000219151.4_5'UTR	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	225					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TCCCACTGGTGAAGAAGATGA	0.502													21	56					0	0	1	0	0	A	20682930	G	A	20682930	2	1	48	1	0	0	0	0	0	0	0	1	182	1281	45	3		3	ACSM1	16	20682930	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	128376	20682930	69671823	3451	7845										
DNAH3	55567	broad.mit.edu	37	chr16	20944541	20944541	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcttctggggcatgtctgTtggaagctcaatggagagga	16	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20944541T>C	ENST00000261383.3	-	62	12285	c.12286A>G	c.(12286-12288)Aca>Gca	p.T4096A	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4096					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GGCATGTCTGTTGGAAGCTCA	0.498													45	85					0	0	1	0	0	C	20944541	T	C	20944541	3	2	48	1	0	0	0	0	1	0	0	0	4631	1725	60	4	67	4	DNAH3	16	20944541	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	261611	20944541	69410212	3452	7846										
DNAH3	55567	broad.mit.edu	37	chr16	20944632	20944632	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttgtagactggacacacAtagatgtcctgatgcagaaa	10	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:20944632A>C	ENST00000261383.3	-	62	12194	c.12195T>G	c.(12193-12195)taT>taG	p.Y4065*	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4065					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CTGGACACACATAGATGTCCT	0.512													12	123					0	0	1	0	0	C	20944632	A	C	20944632	4	2	48	1	0	0	0	0	0	1	0	0	4631	224	8	4	158	4	DNAH3	16	20944632	Nonsense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	91	20944632	69410121	3453	7847										
DNAH3	55567	broad.mit.edu	37	chr16	21011661	21011661	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgaggttctggcagagaaAttgatgcagttgggtaggta	16	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:21011661A>T	ENST00000261383.3	-	43	6305	c.6306T>A	c.(6304-6306)aaT>aaA	p.N2102K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2102	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGGCAGAGAAATTGATGCAGT	0.517													27	51					0	0	1	0	0	T	21011661	A	T	21011661	3	4	48	1	0	0	0	0	1	0	0	0	4631	98	4	4	6123	4	DNAH3	16	21011661	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	67029	21011661	69343092	3454	7848										
DNAH3	55567	broad.mit.edu	37	chr16	21145624	21145624	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagcatcatggggttcacCgtgtgcagatgctcctcgtt	12	11	2	2	rs138812210		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:21145624C>T	ENST00000261383.3	-	7	1037	c.1038G>A	c.(1036-1038)acG>acA	p.T346T	DNAH3_ENST00000415178.1_Silent_p.T346T	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	346	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGGGGTTCACCGTGTGCAGAT	0.527													45	86					0	0	1	0	0	T	21145624	C	T	21145624	2	4	48	1	0	0	0	0	0	0	0	1	4631	639	23	1		1	DNAH3	16	21145624	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	133963	21145624	69209129	3455	7849										
DNAH3	55567	broad.mit.edu	37	chr16	21157311	21157311	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggtgtgcatacctgataGagtccagacggttcctcatt	10	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:21157311G>T	ENST00000261383.3	-	2	215	c.216C>A	c.(214-216)ctC>ctA	p.L72L	DNAH3_ENST00000575491.1_5'UTR|DNAH3_ENST00000415178.1_Silent_p.L72L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	72	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATACCTGATAGAGTCCAGACG	0.552													10	55					1.58986e-06	1.78832e-06	1	1	0	T	21157311	G	T	21157311	2	4	48	1	0	0	0	0	0	0	0	1	4631	929	33	2		2	DNAH3	16	21157311	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11687	21157311	69197442	3456	7850										
ZP2	7783	broad.mit.edu	37	chr16	21218215	21218215	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcccctgggtctcttctaCttgcatagctggacagaaga	10	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:21218215C>A	ENST00000574002.1	-	6	909	c.427G>T	c.(427-429)Gta>Tta	p.V143L	ZP2_ENST00000219593.4_Missense_Mutation_p.V143L|ZP2_ENST00000574091.1_Missense_Mutation_p.V143L			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	143					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		GTCTCTTCTACTTGCATAGCT	0.498													36	82					2.09667e-21	2.89385e-21	1	1	0	A	21218215	C	A	21218215	3	1	48	1	0	0	0	0	1	0	0	0	18257	565	20	5	1870	5	ZP2	16	21218215	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	60904	21218215	69136538	3457	7851										
COG7	91949	broad.mit.edu	37	chr16	23415025	23415025	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaactcacgtccatcttcGaaataagcaacagctgttgt	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:23415025G>A	ENST00000307149.5	-	13	1978	c.1793C>T	c.(1792-1794)tCg>tTg	p.S598L		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	598					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		GTCCATCTTCGAAATAAGCAA	0.537													23	37					0	0	1	0	0	A	23415025	G	A	23415025	3	1	48	1	0	0	0	0	1	0	0	0	3686	1059	37	1	539	1	COG7	16	23415025	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2196810	23415025	66939728	3458	7852										
UBFD1	56061	broad.mit.edu	37	chr16	23573949	23573949	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctctcgtgccttcaggagCgcctgccaacggtaccgctg	11	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:23573949C>T	ENST00000395878.3	+	5	1015	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C	UBFD1_ENST00000567212.1_Missense_Mutation_p.R203C|UBFD1_ENST00000219638.4_Missense_Mutation_p.R436C|UBFD1_ENST00000571064.1_3'UTR	NM_019116.2	NP_061989.2	O14562	UBFD1_HUMAN	ubiquitin family domain containing 1	212										endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7				GBM - Glioblastoma multiforme(48;0.0331)		CCTTCAGGAGCGCCTGCCAAC	0.517													16	23					0	0	1	0	0	T	23573949	C	T	23573949	3	4	48	1	0	0	0	0	1	0	0	0	16944	768	27	1	652	1	UBFD1	16	23573949	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	158924	23573949	66780804	3459	7853										
DCTN5	84516	broad.mit.edu	37	chr16	23672543	23672543	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtctttattgaggaagatTgtgtggtcaacgcagcacag	12	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:23672543T>G	ENST00000300087.2	+	4	440	c.289T>G	c.(289-291)Tgt>Ggt	p.C97G	DCTN5_ENST00000563998.1_Missense_Mutation_p.C97G|DCTN5_ENST00000568589.1_Missense_Mutation_p.C97G	NM_001199743.1|NM_032486.3	NP_001186672.1|NP_115875.1	Q9BTE1	DCTN5_HUMAN	dynactin 5 (p25)	97						centrosome	transferase activity			endometrium(2)|lung(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	10				GBM - Glioblastoma multiforme(48;0.0156)		TGAGGAAGATTGTGTGGTCAA	0.413													11	35					0	0	1	0	0	G	23672543	T	G	23672543	3	3	48	1	0	0	0	0	1	0	0	0	4333	1812	63	4	303	4	DCTN5	16	23672543	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	98594	23672543	66682210	3460	7854										
PRKCB	5579	broad.mit.edu	37	chr16	23848713	23848713	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggggcttcgggaagcaggGattccagtgccaaggtaggc	17	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:23848713G>A	ENST00000303531.7	+	2	343	c.191G>A	c.(190-192)gGa>gAa	p.G64E	PRKCB_ENST00000498058.1_Intron|PRKCB_ENST00000321728.7_Missense_Mutation_p.G64E	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	64					apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GGGAAGCAGGGATTCCAGTGC	0.547													59	113					0	0	1	0	0	A	23848713	G	A	23848713	3	1	48	1	0	0	0	0	1	0	0	0	12559	1174	41	3	197	3	PRKCB	16	23848713	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	176170	23848713	66506040	3461	7855										
CACNG3	10368	broad.mit.edu	37	chr16	24358084	24358084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggcgtgtgcaagaaaatcGatcacttccctgaagatgct	11	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:24358084G>A	ENST00000005284.3	+	2	1443	c.241G>A	c.(241-243)Gat>Aat	p.D81N		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	81					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CAAGAAAATCGATCACTTCCC	0.582													29	39					0	0	1	0	0	A	24358084	G	A	24358084	3	1	48	1	0	0	0	0	1	0	0	0	2576	1058	37	1	247	1	CACNG3	16	24358084	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	509371	24358084	65996669	3462	7856										
RBBP6	5930	broad.mit.edu	37	chr16	24560270	24560270	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttattttgtgttttagaagtCgaactgaaccagcgatggca	10	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:24560270C>T	ENST00000319715.4	+	3	703	c.271C>T	c.(271-273)Cga>Tga	p.R91*	RBBP6_ENST00000452655.2_Nonsense_Mutation_p.R91*|RBBP6_ENST00000348022.2_Nonsense_Mutation_p.R91*|RBBP6_ENST00000381039.3_Nonsense_Mutation_p.R91*	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	91					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TTTTAGAAGTCGAACTGAACC	0.274													6	7					0	0	1	0	0	T	24560270	C	T	24560270	4	4	48	1	0	0	0	0	0	1	0	0	13154	876	31	1	281	1	RBBP6	16	24560270	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	202186	24560270	65794483	3463	7857										
RBBP6	5930	broad.mit.edu	37	chr16	24582569	24582569	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggttaaaagttcaaaaaaCtctgcatctagtgaaaaagg	9	5	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:24582569C>A	ENST00000319715.4	+	18	4614	c.4182C>A	c.(4180-4182)aaC>aaA	p.N1394K	RBBP6_ENST00000348022.2_Missense_Mutation_p.N1360K|RBBP6_ENST00000381039.3_Missense_Mutation_p.N554K	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1394					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		GTTCAAAAAACTCTGCATCTA	0.398													21	25					6.44725e-10	7.85205e-10	1	1	0	A	24582569	C	A	24582569	3	1	48	1	0	0	0	0	1	0	0	0	13154	564	20	5	4306	5	RBBP6	16	24582569	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22299	24582569	65772184	3464	7858										
TNRC6A	27327	broad.mit.edu	37	chr16	24834300	24834300	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtccgctacagttcaaaaGaagaggtagtgaaggcacaa	12	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:24834300G>T	ENST00000395799.3	+	24	5608	c.5479G>T	c.(5479-5481)Gaa>Taa	p.E1827*	TNRC6A_ENST00000432286.2_Nonsense_Mutation_p.E305*|TNRC6A_ENST00000315183.7_Nonsense_Mutation_p.E1778*	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1827	RRM.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CAGTTCAAAAGAAGAGGTAGT	0.542													52	112					2.81731e-22	3.91347e-22	1	1	0	T	24834300	G	T	24834300	4	4	48	1	0	0	0	0	0	1	0	0	16399	943	33	2	5573	2	TNRC6A	16	24834300	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	251731	24834300	65520453	3465	7859										
GTF3C1	2975	broad.mit.edu	37	chr16	27481617	27481617	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcctggtctttgaaagaGaaacgatcaggctggtccaa	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:27481617G>T	ENST00000356183.4	-	31	4641	c.4626C>A	c.(4624-4626)ttC>ttA	p.F1542L	GTF3C1_ENST00000561623.1_Missense_Mutation_p.F1542L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1542						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CTTTGAAAGAGAAACGATCAG	0.522													61	138					5.82218e-30	8.31339e-30	1	1	0	T	27481617	G	T	27481617	3	4	48	1	0	0	0	0	1	0	0	0	6912	933	33	2	1731	2	GTF3C1	16	27481617	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2647317	27481617	62873136	3466	7860										
CD19	930	broad.mit.edu	37	chr16	28948597	28948597	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccccaaacccccaggcccaGaagaagaggaaggggagggc	14	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:28948597G>T	ENST00000538922.1	+	9	1266	c.1204G>T	c.(1204-1206)Gaa>Taa	p.E402*	CD19_ENST00000324662.3_Nonsense_Mutation_p.E402*|CD19_ENST00000567541.1_Nonsense_Mutation_p.E402*	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	402					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						CCCAGGCCCAGAAGAAGAGGA	0.622													3	18					0.00909568	0.00935351	1	1	0	T	28948597	G	T	28948597	4	4	48	1	0	0	0	0	0	1	0	0	2995	943	33	2	1238	2	CD19	16	28948597	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1466980	28948597	61406156	3467	7861										
TAOK2	9344	broad.mit.edu	37	chr16	30002147	30002147	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggcagagttccaggcccttCggcagcagcttcaacaggag	13	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30002147C>T	ENST00000279394.3	+	18	2891	c.2488C>T	c.(2488-2490)Cgg>Tgg	p.R830W		NM_004783.3	NP_004774.1	Q9UL54	TAOK2_HUMAN	TAO kinase 2	709	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCAGGCCCTTCGGCAGCAGCT	0.602													50	79					0	0	1	0	0	T	30002147	C	T	30002147	3	4	48	1	0	0	0	0	1	0	0	0	15604	875	31	1	4030	1	TAOK2	16	30002147	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1053550	30002147	60352606	3468	7862										
FAM57B	83723	broad.mit.edu	37	chr16	30037010	30037010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccctccccttcctgtgacctCcccattgggctcctgcaccc	6	22	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30037010C>T	ENST00000564806.1	-	3	472	c.427G>A	c.(427-429)Gag>Aag	p.E143K	FAM57B_ENST00000279389.4_Intron|FAM57B_ENST00000380495.4_Intron			Q71RH2	FA57B_HUMAN	family with sequence similarity 57, member B	0	TLC.					endoplasmic reticulum|integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						CCTGTGACCTCCCCATTGGGC	0.607													43	125					0	0	1	0	0	T	30037010	C	T	30037010	3	4	48	1	0	0	0	0	1	0	0	0	5623	870	30	3		3	FAM57B	16	30037010	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34863	30037010	60317743	3469	7863										
ITGAL	0	broad.mit.edu	37	chr16	30507506	30507506	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcactgctctgacagacaTcaacggcgatgggctggtag	12	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30507506T>G	ENST00000356798.6	+	14	1772	c.1592T>G	c.(1591-1593)aTc>aGc	p.I531S	ITGAL_ENST00000568012.1_3'UTR|ITGAL_ENST00000358164.5_Missense_Mutation_p.I448S|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	531					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CTGACAGACATCAACGGCGAT	0.617													23	125					0	0	1	0	0	G	30507506	T	G	30507506	3	3	48	1	0	0	0	0	1	0	0	0	7929	1435	50	4	1646	4	ITGAL	16	30507506	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	470496	30507506	59847247	3470	7864										
FBRS	64319	broad.mit.edu	37	chr16	30680679	30680679	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctggagccaacctggttgGcagcacccccacgcctggca	11	17	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30680679G>T	ENST00000356166.6	+	18	3744	c.2656G>T	c.(2656-2658)Gca>Tca	p.A886S	FBRS_ENST00000395073.2_Missense_Mutation_p.A278S|FBRS_ENST00000287468.5_Missense_Mutation_p.A366S|FBRS_ENST00000568722.1_Missense_Mutation_p.A278S			Q9HAH7	FBRS_HUMAN	fibrosin	366										ovary(1)	1			Colorectal(24;0.103)			AACCTGGTTGGCAGCACCCCC	0.692													19	43					6.94344e-10	8.4399e-10	1	1	0	T	30680679	G	T	30680679	3	4	48	1	0	0	0	0	1	0	0	0	5739	1203	42	5	1138	5	FBRS	16	30680679	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	173173	30680679	59674074	3471	7865										
ZNF629	23361	broad.mit.edu	37	chr16	30793260	30793260	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaggggggtcctcgggatTggggggtttttcctgggtgt	21	5	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30793260T>C	ENST00000262525.4	-	3	2596	c.2389A>G	c.(2389-2391)Aat>Gat	p.N797D		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			TCCTCGGGATTGGGGGGTTTT	0.657													10	135					0	0	1	0	0	C	30793260	T	C	30793260	3	2	48	1	0	0	0	0	1	0	0	0	18109	1812	63	4	224	4	ZNF629	16	30793260	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	112581	30793260	59561493	3472	7866										
FBXL19	54620	broad.mit.edu	37	chr16	30939819	30939819	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgagagaggcacctgaagaAggtgggtggagacgcctgcc	17	10	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30939819A>C	ENST00000338343.4	+	6	1046	c.659A>C	c.(658-660)aAg>aCg	p.K220T	FBXL19_ENST00000471231.2_5'UTR|FBXL19_ENST00000380310.2_Missense_Mutation_p.K240T|FBXL19_ENST00000562319.1_Missense_Mutation_p.K220T|FBXL19_ENST00000565690.1_Splice_Site_p.K147_splice			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	240	Pro-rich.						DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						CACCTGAAGAAGGTGGGTGGA	0.627													12	15					0	0	1	0	0	C	30939819	A	C	30939819	3	2	48	1	0	0	0	0	1	0	0	0	5747	72	3	4	741	4	FBXL19	16	30939819	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	146559	30939819	59414934	3473	7867										
SETD1A	9739	broad.mit.edu	37	chr16	30970433	30970433	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcaaagtatataccagtcGaagacctccaagacccccgt	6	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:30970433G>A	ENST00000262519.8	+	3	858	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						TATACCAGTCGAAGACCTCCA	0.522													61	124					0	0	1	0	0	A	30970433	G	A	30970433	3	1	48	1	0	0	0	0	1	0	0	0	14183	1059	37	1	178	1	SETD1A	16	30970433	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30614	30970433	59384320	3474	7868										
ZNF646	9726	broad.mit.edu	37	chr16	31087953	31087953	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatgctcctgagggccgccGcaggcacaggcccccacgcc	12	19	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31087953G>A	ENST00000394979.2	+	1	731	c.308G>A	c.(307-309)cGc>cAc	p.R103H	ZNF646_ENST00000300850.5_Missense_Mutation_p.R103H			O15015	ZN646_HUMAN	zinc finger protein 646	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						GAGGGCCGCCGCAGGCACAGG	0.617													30	32					0	0	1	0	0	A	31087953	G	A	31087953	3	1	48	1	0	0	0	0	1	0	0	0	18118	1087	38	1	310	1	ZNF646	16	31087953	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	117520	31087953	59266800	3475	7869										
BCKDK	10295	broad.mit.edu	37	chr16	31122015	31122015	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttctccggccagcctgacTttgtcggcatcatctgtact	8	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31122015T>G	ENST00000394951.1	+	9	1272	c.649T>G	c.(649-651)Ttt>Gtt	p.F217V	BCKDK_ENST00000394950.3_Missense_Mutation_p.F217V|BCKDK_ENST00000219794.6_Missense_Mutation_p.F217V|BCKDK_ENST00000287507.3_Missense_Mutation_p.F217V			O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	217	Histidine kinase.				branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			breast(1)|stomach(1)	2						CCAGCCTGACTTTGTCGGCAT	0.577													7	135					0	0	1	0	0	G	31122015	T	G	31122015	3	3	48	1	0	0	0	0	1	0	0	0	1359	1609	56	4	675	4	BCKDK	16	31122015	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	34062	31122015	59232738	3476	7870										
PRSS8	5652	broad.mit.edu	37	chr16	31143831	31143831	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcggctcctcaggcttggcGtcgatgttgtacaggcagtt	14	10	1	0	rs148214625	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31143831G>A	ENST00000317508.6	-	5	887	c.624C>T	c.(622-624)gaC>gaT	p.D208D	PRSS8_ENST00000568261.1_Silent_p.D154D	NM_002773.3	NP_002764.1	Q16651	PRSS8_HUMAN	protease, serine, 8	208	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	8						CAGGCTTGGCGTCGATGTTGT	0.607													25	46					0	0	1	0	0	A	31143831	G	A	31143831	2	1	48	1	0	0	0	0	0	0	0	1	12683	1136	40	1		1	PRSS8	16	31143831	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	21816	31143831	59210922	3477	7871										
ITGAM	3684	broad.mit.edu	37	chr16	31341654	31341654	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccatcgctgtctgccagaGaatccagtgtgacatcccgt	9	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31341654G>T	ENST00000544665.3	+	27	3160	c.3089G>T	c.(3088-3090)aGa>aTa	p.R1030I	ITGAM_ENST00000287497.8_Missense_Mutation_p.R1029I	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1029					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GTCTGCCAGAGAATCCAGTGT	0.557													22	55					7.45023e-12	9.31775e-12	1	1	0	T	31341654	G	T	31341654	3	4	48	1	0	0	0	0	1	0	0	0	7930	942	33	2	3195	2	ITGAM	16	31341654	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	197823	31341654	59013099	3478	7872										
ARMC5	79798	broad.mit.edu	37	chr16	31471145	31471145	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgtcggccgcgtcgggagcTtctagccccgcccccgcgtc	13	19	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31471145T>G	ENST00000457010.2	+	1	1001	c.300T>G	c.(298-300)gcT>gcG	p.A100A	ARMC5_ENST00000408912.3_Silent_p.A195A|ARMC5_ENST00000268314.4_Silent_p.A100A|ARMC5_ENST00000538189.1_Silent_p.A132A|ARMC5_ENST00000563544.1_Silent_p.A100A	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	100							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CGTCGGGAGCTTCTAgccccg	0.761													4	6					0	0	1	0	0	G	31471145	T	G	31471145	2	3	48	1	0	0	0	0	0	0	0	1	953	1596	56	4		4	ARMC5	16	31471145	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	129491	31471145	58883608	3479	7873										
SLC5A2	6524	broad.mit.edu	37	chr16	31500065	31500065	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgcgcctgcggccacgcgccGgcgaccgcgagctgctgctg	16	18	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31500065G>A	ENST00000330498.3	+	10	1271	c.1252G>A	c.(1252-1254)Ggc>Agc	p.G418S		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	418					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GCCACGCGCCGGCGACCGCGA	0.711													12	26					0	0	1	0	0	A	31500065	G	A	31500065	3	1	48	1	0	0	0	0	1	0	0	0	14719	1116	39	1	1290	1	SLC5A2	16	31500065	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	28920	31500065	58854688	3480	7874										
ZNF267	10308	broad.mit.edu	37	chr16	31925870	31925870	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcattccaaaaagtgatatcGaggagacatgggagctgtga	12	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31925870G>A	ENST00000300870.10	+	4	509	c.300G>A	c.(298-300)tcG>tcA	p.S100S	RP11-170L3.8_ENST00000575471.1_RNA|ZNF267_ENST00000394846.3_3'UTR	NM_001265588.1|NM_003414.5	NP_001252517.1|NP_003405.3	Q14586	ZN267_HUMAN	zinc finger protein 267	100					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(5)|kidney(1)|large_intestine(14)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	41						AAGTGATATCGAGGAGACATG	0.368													4	67					0	0	1	0	0	A	31925870	G	A	31925870	2	1	48	1	0	0	0	0	0	0	0	1	17863	1045	37	1		1	ZNF267	16	31925870	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	425805	31925870	58428883	3481	7875										
ZNF267	10308	broad.mit.edu	37	chr16	31926769	31926769	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatcttattgtgcatcagaGaattcacactggagagaaac	8	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:31926769G>T	ENST00000300870.10	+	4	1408	c.1199G>T	c.(1198-1200)aGa>aTa	p.R400I	RP11-170L3.8_ENST00000575471.1_RNA	NM_001265588.1|NM_003414.5	NP_001252517.1|NP_003405.3	Q14586	ZN267_HUMAN	zinc finger protein 267	400					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(5)|kidney(1)|large_intestine(14)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	41						GTGCATCAGAGAATTCACACT	0.368													16	41					0.00316338	0.00328853	1	1	0	T	31926769	G	T	31926769	3	4	48	1	0	0	0	0	1	0	0	0	17863	942	33	2	1213	2	ZNF267	16	31926769	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	899	31926769	58427984	3482	7876										
MYLK3	91807	broad.mit.edu	37	chr16	46746599	46746599	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacactccacatgtctgtgGggaatgagacaaactcataa	8	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:46746599G>T	ENST00000394809.4	-	10	2190	c.2075C>A	c.(2074-2076)cCc>cAc	p.P692H	MYLK3_ENST00000536476.1_Missense_Mutation_p.P351H	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	692	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CATGTCTGTGGGGAATGAGAC	0.527													24	69					2.98393e-07	3.42142e-07	1	1	0	T	46746599	G	T	46746599	3	4	48	1	0	0	0	0	1	0	0	0	10105	1232	43	5	400	5	MYLK3	16	46746599	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	14819830	46746599	43608154	3483	7877										
ABCC12	94160	broad.mit.edu	37	chr16	48121866	48121866	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctacaaacaggacaggatcCtgtgggatcacagtcagctt	10	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:48121866C>T	ENST00000311303.3	-	25	3951	c.3606G>A	c.(3604-3606)caG>caA	p.Q1202Q	ABCC12_ENST00000448542.1_3'UTR|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1202	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GGACAGGATCCTGTGGGATCA	0.438													10	41					0	0	1	0	0	T	48121866	C	T	48121866	2	4	48	1	0	0	0	0	0	0	0	1	52	680	24	3		3	ABCC12	16	48121866	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1375267	48121866	42232887	3484	7878										
ABCC12	94160	broad.mit.edu	37	chr16	48138169	48138169	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaactgctgcagaaagttCtctgcgtgaaacggcagcct	10	10	1	2	rs141043396	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:48138169C>A	ENST00000311303.3	-	20	3129	c.2784G>T	c.(2782-2784)gaG>gaT	p.E928D	ABCC12_ENST00000448542.1_Intron|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	928	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GCAGAAAGTTCTCTGCGTGAA	0.498													51	100					2.01872e-29	2.87446e-29	1	1	0	A	48138169	C	A	48138169	3	1	48	1	0	0	0	0	1	0	0	0	52	912	32	2	1335	2	ABCC12	16	48138169	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16303	48138169	42216584	3485	7879										
ABCC12	94160	broad.mit.edu	37	chr16	48145699	48145699	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagttaccttgaactgcaaTcctcgcaggttgtgaatcag	10	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:48145699T>C	ENST00000311303.3	-	14	2457	c.2112A>G	c.(2110-2112)ggA>ggG	p.G704G	ABCC12_ENST00000448542.1_Silent_p.G704G|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	704						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TGAACTGCAATCCTCGCAGGT	0.483													23	59					0	0	1	0	0	C	48145699	T	C	48145699	2	2	48	1	0	0	0	0	0	0	0	1	52	1422	50	4		4	ABCC12	16	48145699	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7530	48145699	42209054	3486	7880										
N4BP1	9683	broad.mit.edu	37	chr16	48594765	48594765	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtatttttagagtatctcGaaacctttgaaccccagtaa	8	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:48594765G>A	ENST00000262384.3	-	2	2025	c.1789C>T	c.(1789-1791)Cga>Tga	p.R597*	RP11-44I10.3_ENST00000563994.1_RNA	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	597					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				AGAGTATCTCGAAACCTTTGA	0.428													41	72					0	0	1	0	0	A	48594765	G	A	48594765	4	1	48	1	0	0	0	0	0	1	0	0	10156	1066	37	1	925	1	N4BP1	16	48594765	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	449066	48594765	41759988	3487	7881										
C16orf78	123970	broad.mit.edu	37	chr16	49412424	49412424	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacgccgcctcctaccgaaGcctctatggagtggagcaaa	12	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:49412424G>T	ENST00000299191.3	+	3	431	c.314G>T	c.(313-315)aGc>aTc	p.S105I		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	105										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						TCCTACCGAAGCCTCTATGGA	0.567													3	12					1	1	1	1	0	T	49412424	G	T	49412424	3	4	48	1	0	0	0	0	1	0	0	0	1842	971	34	5	324	5	C16orf78	16	49412424	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	817659	49412424	40942329	3488	7882										
ADCY7	113	broad.mit.edu	37	chr16	50326626	50326626	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcctgtgtgggaacctgAcaggcgccttccacaagcac	10	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:50326626A>C	ENST00000394697.2	+	5	917	c.577A>C	c.(577-579)Aca>Cca	p.T193P	ADCY7_ENST00000538642.1_Missense_Mutation_p.T193P|ADCY7_ENST00000537579.1_Missense_Mutation_p.T193P|ADCY7_ENST00000566433.2_Missense_Mutation_p.T193P|ADCY7_ENST00000254235.3_Missense_Mutation_p.T193P|ADCY7_ENST00000564044.1_3'UTR			P51828	ADCY7_HUMAN	adenylate cyclase 7	193					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TGGGAACCTGACAGGCGCCTT	0.597													23	55					0	0	1	0	0	C	50326626	A	C	50326626	3	2	48	1	0	0	0	0	1	0	0	0	298	275	10	4	591	4	ADCY7	16	50326626	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	914202	50326626	40028127	3489	7883										
BRD7	29117	broad.mit.edu	37	chr16	50384060	50384060	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagtcacaggaaatgaaaaGaaagcacttggatcttttct	8	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:50384060G>T	ENST00000394688.3	-	5	624	c.465C>A	c.(463-465)ttC>ttA	p.F155L	BRD7_ENST00000401491.3_5'UTR|BRD7_ENST00000394689.2_Missense_Mutation_p.F155L			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	155	Bromo.				cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				GAAATGAAAAGAAAGCACTTG	0.333													6	29					0.0215528	0.0219788	1	1	0	T	50384060	G	T	50384060	3	4	48	1	0	0	0	0	1	0	0	0	1507	933	33	2	1545	2	BRD7	16	50384060	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	57434	50384060	39970693	3490	7884										
NKD1	85407	broad.mit.edu	37	chr16	50667564	50667564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggtggccctgtcctggggCgggagcacctgcgggagctg	19	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:50667564C>T	ENST00000268459.3	+	10	1509	c.1285C>T	c.(1285-1287)Cgg>Tgg	p.R429W		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	429					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TGTCCTGGGGCGGGAGCACCT	0.682													5	15					0	0	1	0	0	T	50667564	C	T	50667564	3	4	48	1	0	0	0	0	1	0	0	0	10487	759	27	1	1323	1	NKD1	16	50667564	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	283504	50667564	39687189	3491	7885										
AKTIP	64400	broad.mit.edu	37	chr16	53528122	53528122	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaccttaacactgtcaacaActttacttttaaaaagctga	3	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:53528122A>C	ENST00000300245.4	-	9	855	c.638T>G	c.(637-639)gTt>gGt	p.V213G	AKTIP_ENST00000570004.1_Missense_Mutation_p.V213G|AKTIP_ENST00000394657.6_Missense_Mutation_p.V213G			Q9H8T0	AKTIP_HUMAN	AKT interacting protein	213					apoptosis|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|positive regulation of protein binding|positive regulation of protein phosphorylation|protein transport	FHF complex|plasma membrane	acid-amino acid ligase activity|protein binding			large_intestine(1)|lung(2)|prostate(2)	5		all_cancers(37;0.14)				ACTGTCAACAACTTTACTTTT	0.348													12	38					0	0	1	0	0	C	53528122	A	C	53528122	3	2	48	1	0	0	0	0	1	0	0	0	479	43	2	4	252	4	AKTIP	16	53528122	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2860558	53528122	36826631	3492	7886										
RPGRIP1L	23322	broad.mit.edu	37	chr16	53682877	53682877	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaagccaaatgagcttaccGactgcatatgctctggcccc	8	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:53682877G>A	ENST00000262135.4	-	16	2396	c.2304_splice	c.e16+1	p.S768_splice	RPGRIP1L_ENST00000564374.1_Splice_Site_p.S768_splice|RPGRIP1L_ENST00000379925.3_Splice_Site_p.S768_splice|RPGRIP1L_ENST00000563746.1_Splice_Site_p.S768_splice	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	768					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TGAGCTTACCGACTGCATATG	0.353													11	61					0	0	1	0	0	A	53682877	G	A	53682877	5	1	48	1	0	0	0	0	0	0	1	0	13601	1072	37	1	1692	1	RPGRIP1L	16	53682877	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	154755	53682877	36671876	3493	7887										
IRX3	79191	broad.mit.edu	37	chr16	54319319	54319319	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggccagcatgatcttctcGcccttggtggggtaggggtt	15	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:54319319G>A	ENST00000329734.3	-	2	1186	c.474C>T	c.(472-474)ggC>ggT	p.G158G		NM_024336.2	NP_077312.2	P78415	IRX3_HUMAN	iroquois homeobox 3	158					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|soft_tissue(1)|urinary_tract(1)	14						TGATCTTCTCGCCCTTGGTGG	0.622													40	101					0	0	1	0	0	A	54319319	G	A	54319319	2	1	48	1	0	0	0	0	0	0	0	1	7888	1074	38	1		1	IRX3	16	54319319	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	636442	54319319	36035434	3494	7888										
SLC6A2	6530	broad.mit.edu	37	chr16	55733485	55733485	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagtggacaggttcagcaaCgacatccagcagatgatggg	15	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:55733485C>T	ENST00000379906.2	+	11	1764	c.1509C>T	c.(1507-1509)aaC>aaT	p.N503N	SLC6A2_ENST00000566163.1_Silent_p.N458N|SLC6A2_ENST00000567238.1_Silent_p.N398N|SLC6A2_ENST00000414754.3_Silent_p.N503N|SLC6A2_ENST00000561820.1_Silent_p.N503N|SLC6A2_ENST00000219833.8_Silent_p.N503N|SLC6A2_ENST00000568943.1_Silent_p.N503N	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	503					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GGTTCAGCAACGACATCCAGC	0.597													22	45					0	0	1	0	0	T	55733485	C	T	55733485	2	4	48	1	0	0	0	0	0	0	0	1	14737	535	19	1		1	SLC6A2	16	55733485	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1414166	55733485	34621268	3495	7889										
GNAO1	2775	broad.mit.edu	37	chr16	56377721	56377721	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttacatccaggcccagtaCgagagcaagaacaagtcagc	10	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:56377721C>T	ENST00000262494.7	+	8	1184	c.924C>T	c.(922-924)taC>taT	p.Y308Y	GNAO1_ENST00000262493.6_Intron	NM_138736.2	NP_620073.2	P09471	GNAO_HUMAN	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	308					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)	17		all_neural(199;0.159)				AGGCCCAGTACGAGAGCAAGA	0.577													13	26					0	0	1	0	0	T	56377721	C	T	56377721	2	4	48	1	0	0	0	0	0	0	0	1	6549	547	19	1		1	GNAO1	16	56377721	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	644236	56377721	33977032	3496	7890										
CETP	1071	broad.mit.edu	37	chr16	57009049	57009049	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggcttcaacaccaaccagGaaatcttccaagaggtaact	9	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:57009049G>A	ENST00000200676.3	+	10	1097	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	CETP_ENST00000379780.2_Missense_Mutation_p.E263K|CETP_ENST00000566128.1_Missense_Mutation_p.E258K	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	323					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						CACCAACCAGGAAATCTTCCA	0.527													24	32					0	0	1	0	0	A	57009049	G	A	57009049	3	1	48	1	0	0	0	0	1	0	0	0	3299	1175	41	3	1005	3	CETP	16	57009049	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	631328	57009049	33345704	3497	7891										
NLRC5	84166	broad.mit.edu	37	chr16	57113472	57113472	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccagcctggtttcctgtaAgattgacaaccagactgcca	8	14	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:57113472A>C	ENST00000262510.6	+	46	5477	c.5252A>C	c.(5251-5253)aAg>aCg	p.K1751T	NLRC5_ENST00000436936.1_3'UTR|NLRC5_ENST00000539144.1_Missense_Mutation_p.K1722T|NLRC5_ENST00000308149.7_Missense_Mutation_p.K1722T	NM_032206.4	NP_115582.4	Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1751					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GTTTCCTGTAAGATTGACAAC	0.577													48	103					0	0	1	0	0	C	57113472	A	C	57113472	3	2	48	1	0	0	0	0	1	0	0	0	10516	72	3	4	5426	4	NLRC5	16	57113472	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	104423	57113472	33241281	3498	7892										
CPNE2	221184	broad.mit.edu	37	chr16	57155661	57155661	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcgggcatcatcatcctgCgatcctgcaaggtgaaccag	10	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:57155661C>T	ENST00000535318.2	+	10	1217	c.856C>T	c.(856-858)Cga>Tga	p.R286*	CPNE2_ENST00000537605.1_Nonsense_Mutation_p.R184*|CPNE2_ENST00000565874.1_Nonsense_Mutation_p.R286*|CPNE2_ENST00000290776.8_Nonsense_Mutation_p.R286*			Q96FN4	CPNE2_HUMAN	copine II	286										central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				CATCATCCTGCGATCCTGCAA	0.547													16	119					0	0	1	0	0	T	57155661	C	T	57155661	4	4	48	1	0	0	0	0	0	1	0	0	3835	760	27	1	886	1	CPNE2	16	57155661	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	42189	57155661	33199092	3499	7893										
CIAPIN1	57019	broad.mit.edu	37	chr16	57466419	57466419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgctgtcgtcctccatatCgttggctgagagggtccaca	11	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:57466419C>T	ENST00000394391.4	-	6	851	c.610G>A	c.(610-612)Gat>Aat	p.D204N	CIAPIN1_ENST00000569246.1_5'UTR|CIAPIN1_ENST00000567518.1_Missense_Mutation_p.D191N|CIAPIN1_ENST00000569979.1_Missense_Mutation_p.D204N|CIAPIN1_ENST00000568940.1_Missense_Mutation_p.D204N|CIAPIN1_ENST00000569370.1_Missense_Mutation_p.D204N|CIAPIN1_ENST00000565961.1_Missense_Mutation_p.D177N	NM_020313.2	NP_064709.2	Q6FI81	CPIN1_HUMAN	cytokine induced apoptosis inhibitor 1	204					anti-apoptosis|apoptosis	cytoplasm|nucleolus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						TCCTCCATATCGTTGGCTGAG	0.488													28	60					0	0	1	0	0	T	57466419	C	T	57466419	3	4	48	1	0	0	0	0	1	0	0	0	3441	884	31	1	344	1	CIAPIN1	16	57466419	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	310758	57466419	32888334	3500	7894										
CNGB1	1258	broad.mit.edu	37	chr16	57950065	57950065	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacttcaggtagttatttcGcatgtcctttttgtccgtct	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:57950065G>A	ENST00000564448.1	-	22	2227	c.2167C>T	c.(2167-2169)Cga>Tga	p.R723*	CNGB1_ENST00000251102.8_Nonsense_Mutation_p.R729*			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	729					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						TAGTTATTTCGCATGTCCTTT	0.512													39	64					0	0	1	0	0	A	57950065	G	A	57950065	4	1	48	1	0	0	0	0	0	1	0	0	3623	1095	38	1	1618	1	CNGB1	16	57950065	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	483646	57950065	32404688	3501	7895										
ZNF319	0	broad.mit.edu	37	chr16	58031930	58031930	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcgccaggtcgtgaccacaCacgccacatttggggcctgg	13	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:58031930C>G	ENST00000299237.2	-	2	862	c.240G>C	c.(238-240)gtG>gtC	p.V80V		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						CGTGACCACACACGCCACATT	0.642													24	41					0	0	1	0	0	G	58031930	C	G	58031930	2	3	48	1	0	0	0	0	0	0	0	1	17893	465	17	5		5	ZNF319	16	58031930	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	81865	58031930	32322823	3502	7896										
CNOT1	23019	broad.mit.edu	37	chr16	58589167	58589167	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacttacctgtttttaaatCtatctagtgcagcaatcccg	5	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:58589167C>A	ENST00000317147.5	-	21	3211	c.2879G>T	c.(2878-2880)aGa>aTa	p.R960I	CNOT1_ENST00000569732.1_5'UTR|CNOT1_ENST00000569240.1_Missense_Mutation_p.R955I|CNOT1_ENST00000441024.2_Missense_Mutation_p.R960I	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	960					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GTTTTTAAATCTATCTAGTGC	0.468													34	41					2.68265e-12	3.37613e-12	1	1	0	A	58589167	C	A	58589167	3	1	48	1	0	0	0	0	1	0	0	0	3640	913	32	2	4589	2	CNOT1	16	58589167	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	557237	58589167	31765586	3503	7897										
CDH8	1006	broad.mit.edu	37	chr16	61858924	61858924	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaattaacttactctgtgcaAattttggaggattgtcatta	7	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:61858924A>G	ENST00000577390.1	-	5	1781	c.827T>C	c.(826-828)tTt>tCt	p.F276S	CDH8_ENST00000577730.1_Missense_Mutation_p.F276S|CDH8_ENST00000584337.1_Missense_Mutation_p.F276S|CDH8_ENST00000299345.6_Missense_Mutation_p.F276S	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	276	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ACTCTGTGCAAATTTTGGAGG	0.373													14	28					0	0	1	0	0	G	61858924	A	G	61858924	3	3	48	1	0	0	0	0	1	0	0	0	3138	14	1	4	1604	4	CDH8	16	61858924	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3269757	61858924	28495829	3504	7898										
CDH11	1009	broad.mit.edu	37	chr16	65016055	65016055	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggatgtaacttggggccaaGaacatagggggctcatcagc	14	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:65016055G>T	ENST00000394156.3	-	8	1602	c.1149C>A	c.(1147-1149)ttC>ttA	p.F383L	CDH11_ENST00000566827.1_Missense_Mutation_p.F257L|CDH11_ENST00000268603.4_Missense_Mutation_p.F383L			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	383	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TTGGGGCCAAGAACATAGGGG	0.532			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			41	53					6.2361e-21	8.5756e-21	1	1	0	T	65016055	G	T	65016055	3	4	48	1	0	0	0	0	1	0	0	0	3119	933	33	2	1265	2	CDH11	16	65016055	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3157131	65016055	25338698	3505	7899										
TK2	7084	broad.mit.edu	37	chr16	66565347	66565347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgtagcgtaagaccccagCgagaggcatcgtggtacatc	12	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:66565347C>T	ENST00000299697.7	-	5	661	c.437G>A	c.(436-438)cGc>cAc	p.R146H	TK2_ENST00000544898.1_Missense_Mutation_p.R55H|TK2_ENST00000417693.3_Missense_Mutation_p.R86H|TK2_ENST00000563369.2_Missense_Mutation_p.R7H|TK2_ENST00000525974.1_Missense_Mutation_p.R7H|TK2_ENST00000564917.1_Missense_Mutation_p.R104H|TK2_ENST00000527800.1_Missense_Mutation_p.R7H|TK2_ENST00000451102.2_Missense_Mutation_p.R104H|TK2_ENST00000545043.2_Missense_Mutation_p.R79H|TK2_ENST00000527284.1_Missense_Mutation_p.R73H	NM_001172644.1|NM_001172645.1|NM_001271934.1|NM_001271935.1|NM_001272050.1|NM_004614.4	NP_001166115.1|NP_001166116.1|NP_001258863.1|NP_001258864.1|NP_001258979.1|NP_004605.4	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	104					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity			large_intestine(1)|lung(2)|urinary_tract(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)		AAGACCCCAGCGAGAGGCATC	0.522													10	52					0	0	1	0	0	T	66565347	C	T	66565347	3	4	48	1	0	0	0	0	1	0	0	0	15992	768	27	1	510	1	TK2	16	66565347	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1549292	66565347	23789406	3506	7900										
C16orf70	80262	broad.mit.edu	37	chr16	67168075	67168075	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacctttgtttgcagcccaAttttgcccatggcctggctt	9	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67168075A>G	ENST00000219139.3	+	7	643	c.455A>G	c.(454-456)aAt>aGt	p.N152S	C16orf70_ENST00000569683.1_3'UTR|C16orf70_ENST00000569600.1_Missense_Mutation_p.N152S	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	152										cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		TTGCAGCCCAATTTTGCCCAT	0.493													27	48					0	0	1	0	0	G	67168075	A	G	67168075	3	3	48	1	0	0	0	0	1	0	0	0	1836	101	4	4	481	4	C16orf70	16	67168075	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	602728	67168075	23186678	3507	7901										
TMEM208	29100	broad.mit.edu	37	chr16	67262716	67262716	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaggcaccttaaggatgtgAtcctactgacagccatcgtg	10	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67262716A>G	ENST00000563953.1	+	5	532	c.106A>G	c.(106-108)Atc>Gtc	p.I36V	TMEM208_ENST00000563426.1_3'UTR|TMEM208_ENST00000565201.1_Missense_Mutation_p.I106V|TMEM208_ENST00000304800.9_Missense_Mutation_p.I106V			Q9BTX3	TM208_HUMAN	transmembrane protein 208	106						integral to membrane				breast(1)|kidney(2)|lung(1)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TAAGGATGTGATCCTACTGAC	0.527													35	68					0	0	1	0	0	G	67262716	A	G	67262716	3	3	48	1	0	0	0	0	1	0	0	0	16192	333	12	4	334	4	TMEM208	16	67262716	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	94641	67262716	23092037	3508	7902										
KCTD19	146212	broad.mit.edu	37	chr16	67329205	67329205	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagtttgccaagtctcaggAagttgagaatgtgtcggaac	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67329205A>G	ENST00000304372.5	-	9	1407	c.1352T>C	c.(1351-1353)tTc>tCc	p.F451S		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	451	BTB 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AAGTCTCAGGAAGTTGAGAAT	0.478													19	23					0	0	1	0	0	G	67329205	A	G	67329205	3	3	48	1	0	0	0	0	1	0	0	0	8149	246	9	4	1460	4	KCTD19	16	67329205	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	66489	67329205	23025548	3509	7903										
KCTD19	146212	broad.mit.edu	37	chr16	67335823	67335823	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctgtgagcgaagaaaatTcacttgaaaaacaaagggga	10	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67335823T>C	ENST00000304372.5	-	5	701	c.646A>G	c.(646-648)Aat>Gat	p.N216D	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	216						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CGAAGAAAATTCACTTGAAAA	0.403													26	76					0	0	1	0	0	C	67335823	T	C	67335823	3	2	48	1	0	0	0	0	1	0	0	0	8149	1783	62	4	2182	4	KCTD19	16	67335823	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	6618	67335823	23018930	3510	7904										
KCTD19	146212	broad.mit.edu	37	chr16	67338374	67338374	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagggtttgctaatacacTtccatgtacgccagtagttc	9	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67338374T>G	ENST00000304372.5	-	3	456	c.401A>C	c.(400-402)aAg>aCg	p.K134T	KCTD19_ENST00000562860.1_Intron	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	134						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GCTAATACACTTCCATGTACG	0.488													38	70					0	0	1	0	0	G	67338374	T	G	67338374	3	3	48	1	0	0	0	0	1	0	0	0	8149	1609	56	4	2435	4	KCTD19	16	67338374	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2551	67338374	23016379	3511	7905										
CTCF	10664	broad.mit.edu	37	chr16	67645132	67645132	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgctaccacttcagtagaaGaacttcagggggcttatgaa	10	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67645132G>T	ENST00000264010.4	+	3	841	c.397G>T	c.(397-399)Gaa>Taa	p.E133*	CTCF_ENST00000401394.1_Intron	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	133					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TTCAGTAGAAGAACTTCAGGG	0.458													28	66					3.57733e-08	4.18982e-08	1	1	0	T	67645132	G	T	67645132	4	4	48	1	0	0	0	0	0	1	0	0	4024	943	33	2	399	2	CTCF	16	67645132	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	306758	67645132	22709621	3512	7906										
RLTPR	146206	broad.mit.edu	37	chr16	67681792	67681792	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggccaccaatgccgccttCgactccaccctgacccacct	6	21	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67681792C>T	ENST00000334583.6	+	13	1330	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F	RLTPR_ENST00000545661.1_Silent_p.F334F	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	334								p.F334F(1)		breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		ATGCCGCCTTCGACTCCACCC	0.672													9	18					0	0	1	0	0	T	67681792	C	T	67681792	2	4	48	1	0	0	0	0	0	0	0	1	13445	883	31	1		1	RLTPR	16	67681792	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	36660	67681792	22672961	3513	7907										
NUTF2	10204	broad.mit.edu	37	chr16	67899124	67899124	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgatagaacccaactaggcGcaatttacgtaagtttccag	8	9	0	2	rs146730920		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67899124G>A	ENST00000219169.4	+	2	374	c.91G>A	c.(91-93)Gca>Aca	p.A31T	NUTF2_ENST00000569436.2_Missense_Mutation_p.A31T|NUTF2_ENST00000568396.2_Missense_Mutation_p.A31T	NM_005796.1	NP_005787.1	P61970	NTF2_HUMAN	nuclear transport factor 2	31	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity	p.A31P(1)		kidney(1)|lung(2)|upper_aerodigestive_tract(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		CCAACTAGGCGCAATTTACGT	0.468													14	28					0	0	1	0	0	A	67899124	G	A	67899124	3	1	48	1	0	0	0	0	1	0	0	0	10826	1087	38	1	93	1	NUTF2	16	67899124	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	217332	67899124	22455629	3514	7908										
SLC12A4	6560	broad.mit.edu	37	chr16	67991677	67991677	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgttggtggcgatggcactcAtggagatggccgtcagcagg	17	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:67991677A>G	ENST00000422611.2	-	4	557	c.518T>C	c.(517-519)aTg>aCg	p.M173T	SLC12A4_ENST00000572037.1_Missense_Mutation_p.M123T|SLC12A4_ENST00000576616.1_Missense_Mutation_p.M171T|SLC12A4_ENST00000572010.1_5'UTR|SLC12A4_ENST00000316341.3_Missense_Mutation_p.M171T|SLC12A4_ENST00000541864.2_Missense_Mutation_p.M140T|SLC12A4_ENST00000537830.2_Missense_Mutation_p.M165T|SLC12A4_ENST00000338335.3_Missense_Mutation_p.M171T	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	171					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GATGGCACTCATGGAGATGGC	0.647													18	29					0	0	1	0	0	G	67991677	A	G	67991677	3	3	48	1	0	0	0	0	1	0	0	0	14439	217	8	4	2825	4	SLC12A4	16	67991677	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	92553	67991677	22363076	3515	7909										
ZFP90	146198	broad.mit.edu	37	chr16	68598587	68598587	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacaccagagaattcatactCgaaataaactctaggaaccg	6	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:68598587C>T	ENST00000570495.1	+	5	2189	c.1897C>T	c.(1897-1899)Cga>Tga	p.R633*	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Nonsense_Mutation_p.R633*|ZFP90_ENST00000563169.2_Nonsense_Mutation_p.R633*			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	633					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R633R(1)		breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		AATTCATACTCGAAATAAACT	0.378													28	34					0	0	1	0	0	T	68598587	C	T	68598587	4	4	48	1	0	0	0	0	0	1	0	0	17711	876	31	1	1911	1	ZFP90	16	68598587	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	606910	68598587	21756166	3516	7910										
VAC14	55697	broad.mit.edu	37	chr16	70765467	70765467	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctcttgagaaggttgatcAtgaacttataaaagtaagaa	8	4	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:70765467A>G	ENST00000261776.5	-	14	1852	c.1592T>C	c.(1591-1593)aTg>aCg	p.M531T		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	531					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				AAGGTTGATCATGAACTTATA	0.468													41	69					0	0	1	0	0	G	70765467	A	G	70765467	3	3	48	1	0	0	0	0	1	0	0	0	17170	217	8	4	780	4	VAC14	16	70765467	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2166880	70765467	19589286	3517	7911										
VAC14	55697	broad.mit.edu	37	chr16	70817355	70817355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttactccactcacattttgcGaatctctttgccattgtcac	4	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:70817355G>A	ENST00000261776.5	-	6	957	c.697C>T	c.(697-699)Cgc>Tgc	p.R233C		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	233					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity	p.R233C(1)		breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				CACATTTTGCGAATCTCTTTG	0.587													22	40					0	0	1	0	0	A	70817355	G	A	70817355	3	1	48	1	0	0	0	0	1	0	0	0	17170	1058	37	1	1707	1	VAC14	16	70817355	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	51888	70817355	19537398	3518	7912										
PMFBP1	83449	broad.mit.edu	37	chr16	72184724	72184724	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccatttcctcctcatagagaAtcacctgtaggtgtaggaat	8	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:72184724A>C	ENST00000537465.1	-	5	577	c.419T>G	c.(418-420)aTt>aGt	p.I140S	PMFBP1_ENST00000355636.6_5'UTR|PMFBP1_ENST00000237353.10_Missense_Mutation_p.I140S			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	140										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CTCATAGAGAATCACCTGTAG	0.498													30	38					0	0	1	0	0	C	72184724	A	C	72184724	3	2	48	1	0	0	0	0	1	0	0	0	12181	101	4	4	2732	4	PMFBP1	16	72184724	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1367369	72184724	18170029	3519	7913										
ZFHX3	463	broad.mit.edu	37	chr16	72829497	72829497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaatcctcattttggctgtCgtcctgcccctcctcatcct	7	16	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:72829497C>T	ENST00000268489.5	-	9	7756	c.7084G>A	c.(7084-7086)Gac>Aac	p.D2362N	ZFHX3_ENST00000397992.5_Missense_Mutation_p.D1448N	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2362					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TTTTGGCTGTCGTCCTGCCCC	0.532													50	74					0	0	1	0	0	T	72829497	C	T	72829497	3	4	48	1	0	0	0	0	1	0	0	0	17691	884	31	1	4035	1	ZFHX3	16	72829497	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	644773	72829497	17525256	3520	7914										
CNTNAP4	85445	broad.mit.edu	37	chr16	76592493	76592493	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgaggcaaaaaggtcagaGaatgtagacagtgctgaggc	15	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:76592493G>T	ENST00000307431.8	+	25	4222	c.3837G>T	c.(3835-3837)gaG>gaT	p.E1279D	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.E1207D|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.E1283D|CNTNAP4_ENST00000469589.1_3'UTR|RP11-58C22.1_ENST00000563764.1_Intron|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.E1231D	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1280					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AAAGGTCAGAGAATGTAGACA	0.373													13	21					4.3838e-07	4.998e-07	1	1	0	T	76592493	G	T	76592493	3	4	48	1	0	0	0	0	1	0	0	0	3672	933	33	2	3947	2	CNTNAP4	16	76592493	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3762996	76592493	13762260	3521	7915										
MON1B	22879	broad.mit.edu	37	chr16	77227525	77227525	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaggagtggcgcagccagcGgaagcatgtgtttgtgctga	17	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:77227525G>A	ENST00000248248.3	+	3	676	c.326G>A	c.(325-327)cGg>cAg	p.R109Q	MON1B_ENST00000320859.6_Missense_Mutation_p.R109Q|MON1B_ENST00000439557.2_Intron|MON1B_ENST00000545553.1_Intron	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	109							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						CGCAGCCAGCGGAAGCATGTG	0.612													21	44					0	0	1	0	0	A	77227525	G	A	77227525	3	1	48	1	0	0	0	0	1	0	0	0	9747	1116	39	1	332	1	MON1B	16	77227525	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	635032	77227525	13127228	3522	7916										
ADAMTS18	170692	broad.mit.edu	37	chr16	77359844	77359844	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgcacactgttgagcccGaaaatccaagctattttcat	6	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:77359844G>A	ENST00000282849.5	-	13	2369	c.1951C>T	c.(1951-1953)Cgg>Tgg	p.R651W		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	651	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGTTGAGCCCGAAAATCCAAG	0.423													21	29					0	0	1	0	0	A	77359844	G	A	77359844	3	1	48	1	0	0	0	0	1	0	0	0	262	1057	37	1	1758	1	ADAMTS18	16	77359844	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	132319	77359844	12994909	3523	7917										
ATMIN	23300	broad.mit.edu	37	chr16	81077539	81077539	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgctcagactgatgcatTtatggacacctgtttccagt	9	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:81077539T>G	ENST00000566488.1	+	3	1931	c.968T>G	c.(967-969)tTt>tGt	p.F323C	ATMIN_ENST00000299575.4_Missense_Mutation_p.F479C|ATMIN_ENST00000564241.1_Missense_Mutation_p.F323C|ATMIN_ENST00000539819.1_3'UTR			O43313	ATMIN_HUMAN	ATM interactor	479	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						ACTGATGCATTTATGGACACC	0.458													39	60					0	0	1	0	0	G	81077539	T	G	81077539	3	3	48	1	0	0	0	0	1	0	0	0	1109	1841	64	4	1450	4	ATMIN	16	81077539	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3717695	81077539	9277214	3524	7918										
PKD1L2	114780	broad.mit.edu	37	chr16	81193409	81193409	+	RNA	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgtgggctcaggatccaCgtgggcagctcatctgtagg	14	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:81193409C>T	ENST00000525539.1	-	0	3713				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TCAGGATCCACGTGGGCAGCT	0.587													6	12					0	0	1	0	0	T	81193409	C	T	81193409	1	4	48	0	1	0	0	0	0	0	0	0	12012	523	19	1		1	PKD1L2	16	81193409	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	115870	81193409	9161344	3525	7919										
PKD1L2	114780	broad.mit.edu	37	chr16	81224277	81224277	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agacaatactcacactctttCcttcagcattcatcccagat	3	14	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:81224277C>A	ENST00000599697.1	-	9	1663	c.1664G>T	c.(1663-1665)gGa>gTa	p.G555V	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	555	REJ.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CACACTCTTTCCTTCAGCATT	0.413													35	79					2.19962e-31	3.1472e-31	1	1	0	A	81224277	C	A	81224277	3	1	48	1	0	0	0	0	1	0	0	0	12012	855	30	2	5924	2	PKD1L2	16	81224277	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30868	81224277	9130476	3526	7920										
BCMO1	53630	broad.mit.edu	37	chr16	81279168	81279168	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagatacaaccattggttCgacggccttgccctgctcca	8	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:81279168C>T	ENST00000425577.2	+	2	373	c.76C>T	c.(76-78)Cga>Tga	p.R26*	BCMO1_ENST00000258168.2_Silent_p.F51F|BCMO1_ENST00000564552.1_Silent_p.F51F			Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	0					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						ACCATTGGTTCGACGGCCTTG	0.577													34	86					0	0	1	0	0	T	81279168	C	T	81279168	4	4	48	1	0	0	0	0	0	1	0	0	1382	883	31	1	159	1	BCMO1	16	81279168	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	54891	81279168	9075585	3527	7921										
CDH13	1012	broad.mit.edu	37	chr16	83816998	83816998	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtgctcctgcaggaattcCaaagtggactgcaacgcggc	13	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:83816998C>A	ENST00000566620.1	+	13	2345	c.2055C>A	c.(2053-2055)tcC>tcA	p.S685S	CDH13_ENST00000428848.3_Silent_p.S646S|CDH13_ENST00000268613.10_Silent_p.S732S	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	685	Cadherin 5.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GCAGGAATTCCAAAGTGGACT	0.532													8	76					0.0381472	0.0387537	1	1	0	A	83816998	C	A	83816998	2	1	48	1	0	0	0	0	0	0	0	1	3121	581	21	5		5	CDH13	16	83816998	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2537830	83816998	6537755	3528	7922										
HSDL1	83693	broad.mit.edu	37	chr16	84163651	84163651	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcaggagccagaagagatCgtgacgatggcacctttctt	12	10	1	3	rs148654230	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:84163651C>T	ENST00000219439.4	-	4	782	c.606G>A	c.(604-606)acG>acA	p.T202T	HSDL1_ENST00000434463.3_Silent_p.T147T	NM_001146051.1|NM_031463.4	NP_001139523.1|NP_113651.4	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1	202						mitochondrion	oxidoreductase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7						CAGAAGAGATCGTGACGATGG	0.483													35	55					0	0	1	0	0	T	84163651	C	T	84163651	2	4	48	1	0	0	0	0	0	0	0	1	7433	871	31	1		1	HSDL1	16	84163651	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	346653	84163651	6191102	3529	7923										
FAM92B	339145	broad.mit.edu	37	chr16	85135934	85135934	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaagtcacaaaaaaatttCtgtggggagagaaacccaaa	8	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:85135934C>A	ENST00000539556.1	-	7	693		c.e7-1			NM_198491.1	NP_940893.1	Q6ZTR7	FA92B_HUMAN	family with sequence similarity 92, member B											breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	16						AAAAAAATTTCTGTGGGGAGA	0.517													12	35					6.40141e-05	6.95424e-05	1	1	0	A	85135934	C	A	85135934	5	1	48	1	0	0	0	0	0	0	1	0	5685	927	32	2	389	2	FAM92B	16	85135934	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	972283	85135934	5218819	3530	7924										
FOXF1	2294	broad.mit.edu	37	chr16	86544588	86544588	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcgaggagggctcctttcGgcggcggccgcgcggcttcc	17	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:86544588G>A	ENST00000262426.4	+	1	456	c.413G>A	c.(412-414)cGg>cAg	p.R138Q		NM_001451.2	NP_001442.2	Q12946	FOXF1_HUMAN	forkhead box F1	138					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(1)	12						GGCTCCTTTCGGCGGCGGCCG	0.647													63	117					0	0	1	0	0	A	86544588	G	A	86544588	3	1	48	1	0	0	0	0	1	0	0	0	6038	1116	39	1	415	1	FOXF1	16	86544588	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1408654	86544588	3810165	3531	7925										
ZCCHC14	23174	broad.mit.edu	37	chr16	87454256	87454256	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggtttcgctccacataaaAtgcgtccggaccagctaagc	10	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:87454256A>G	ENST00000268616.4	-	5	713	c.496T>C	c.(496-498)Ttt>Ctt	p.F166L		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	166					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TCCACATAAAATGCGTCCGGA	0.562													5	21					0	0	1	0	0	G	87454256	A	G	87454256	3	3	48	1	0	0	0	0	1	0	0	0	17641	101	4	4	2389	4	ZCCHC14	16	87454256	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	909668	87454256	2900497	3532	7926										
ZC3H18	124245	broad.mit.edu	37	chr16	88666313	88666313	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaagaaaatgaagtttttCgagattggaattctcggatc	9	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:88666313C>T	ENST00000301011.5	+	6	1245	c.1045C>T	c.(1045-1047)Cga>Tga	p.R349*	ZC3H18_ENST00000452588.2_Nonsense_Mutation_p.R373*	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	349						nucleus	nucleic acid binding|zinc ion binding	p.R349*(2)		endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TGAAGTTTTTCGAGATTGGAA	0.488													44	76					0	0	1	0	0	T	88666313	C	T	88666313	4	4	48	1	0	0	0	0	0	1	0	0	17626	876	31	1	1063	1	ZC3H18	16	88666313	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1212057	88666313	1688440	3533	7927										
CBFA2T3	863	broad.mit.edu	37	chr16	88945713	88945713	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctggttgatgaccgtcaGggcgtcctcggaggcctgcc	15	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:88945713G>T	ENST00000268679.4	-	11	2023	c.1627C>A	c.(1627-1629)Ctg>Atg	p.L543M	CBFA2T3_ENST00000360302.2_Missense_Mutation_p.L457M|CBFA2T3_ENST00000448839.1_Missense_Mutation_p.L467M|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.L505M|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.L457M	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	543					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		ATGACCGTCAGGGCGTCCTCG	0.711			T	RUNX1	AML								5	68					0.0293803	0.0299069	1	1	0	T	88945713	G	T	88945713	3	4	48	1	0	0	0	0	1	0	0	0	2716	991	35	5	342	5	CBFA2T3	16	88945713	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	279400	88945713	1409040	3534	7928										
PRDM7	11105	broad.mit.edu	37	chr16	90124880	90124880	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgttccacatgttgactgaGaaatttttgacttgaaaagg	10	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr16:90124880G>T	ENST00000407825.1	-	9	1032	c.395C>A	c.(394-396)tCt>tAt	p.S132Y	PRDM7_ENST00000325921.6_Missense_Mutation_p.S132Y|PRDM7_ENST00000449207.2_Missense_Mutation_p.F432L			Q9NQW5	PRDM7_HUMAN	PR domain containing 7	340						chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TGTTGACTGAGAAATTTTTGA	0.463													36	85					3.3946e-10	4.15224e-10	1	1	0	T	90124880	G	T	90124880	3	4	48	1	0	0	0	0	1	0	0	0	12512	942	33	2	186	2	PRDM7	16	90124880	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1179167	90124880	229873	3535	7929										
VPS53	55275	broad.mit.edu	37	chr17	465979	465979	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccgatctatcagctctccGaggttcctaggaggaaaaaa	9	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:465979G>A	ENST00000437048.2	-	14	1466	c.1320C>T	c.(1318-1320)ctC>ctT	p.L440L	VPS53_ENST00000291074.5_Silent_p.L411L|VPS53_ENST00000571805.1_Silent_p.L440L|VPS53_ENST00000446250.2_Silent_p.L242L|VPS53_ENST00000576149.1_5'UTR|VPS53_ENST00000574029.1_Intron|VPS53_ENST00000401468.3_Silent_p.L163L	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	440					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TCAGCTCTCCGAGGTTCCTAG	0.468													21	34					0	0	1	0	0	A	465979	G	A	465979	2	1	48	1	0	0	0	0	0	0	0	1	17274	1045	37	1		1	VPS53	17	465979	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08		465979	80729231	3536	7930										
GLOD4	51031	broad.mit.edu	37	chr17	673156	673156	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccatcttagaaagttctcGaaatgcttcatccccgacaa	5	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:673156G>A	ENST00000301329.6	-	8	869	c.784C>T	c.(784-786)Cga>Tga	p.R262*	GLOD4_ENST00000536578.1_Nonsense_Mutation_p.R253*|GLOD4_ENST00000301328.5_Nonsense_Mutation_p.R277*	NM_016080.3	NP_057164.3	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	277						mitochondrion				endometrium(1)|large_intestine(1)|prostate(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		GAAAGTTCTCGAAATGCTTCA	0.448													18	36					0	0	1	0	0	A	673156	G	A	673156	4	1	48	1	0	0	0	0	0	1	0	0	6491	1066	37	1	120	1	GLOD4	17	673156	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	207177	673156	80522054	3537	7931										
SMYD4	114826	broad.mit.edu	37	chr17	1703308	1703308	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcctctcagttgggatggcCtgtaaactggctgcttctag	11	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:1703308C>T	ENST00000305513.7	-	5	1547	c.1380G>A	c.(1378-1380)caG>caA	p.Q460Q		NM_052928.2	NP_443160.2	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	460	SET.						zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(5)|stomach(1)	21						TTGGGATGGCCTGTAAACTGG	0.502													26	37					0	0	1	0	0	T	1703308	C	T	1703308	2	4	48	1	0	0	0	0	0	0	0	1	14877	680	24	3		3	SMYD4	17	1703308	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1030152	1703308	79491902	3538	7932										
RPA1	6117	broad.mit.edu	37	chr17	1782331	1782331	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgagcaagtggacaagttCtttcctcttattgaagtgaa	9	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:1782331C>A	ENST00000254719.5	+	9	845	c.735C>A	c.(733-735)ttC>ttA	p.F245L	RPA1_ENST00000573924.1_3'UTR	NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	245					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						TGGACAAGTTCTTTCCTCTTA	0.557								Nucleotide excision repair (NER)					16	31					1.01871e-10	1.25646e-10	1	1	0	A	1782331	C	A	1782331	3	1	48	1	0	0	0	0	1	0	0	0	13587	912	32	2	769	2	RPA1	17	1782331	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	79023	1782331	79412879	3539	7933										
RTN4RL1	146760	broad.mit.edu	37	chr17	1840609	1840609	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaggttgaccaggtccacGaagatgtcgtcctggaggta	14	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:1840609G>A	ENST00000331238.5	-	2	525	c.507C>T	c.(505-507)ttC>ttT	p.F169F		NM_178568.2	NP_848663.1	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1	169					axon regeneration	anchored to plasma membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|prostate(2)|skin(1)	11						CCAGGTCCACGAAGATGTCGT	0.632													9	45					0	0	1	0	0	A	1840609	G	A	1840609	2	1	48	1	0	0	0	0	0	0	0	1	13782	1049	37	1		1	RTN4RL1	17	1840609	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58278	1840609	79354601	3540	7934										
TSR1	55720	broad.mit.edu	37	chr17	2227591	2227591	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtccatttggggaagactcGtttatacaggttcatcagta	10	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:2227591G>A	ENST00000301364.4	-	15	3393	c.2314C>T	c.(2314-2316)Cga>Tga	p.R772*	SRR_ENST00000344595.5_3'UTR	NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	772					ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						GGGAAGACTCGTTTATACAGG	0.443													32	50					0	0	1	0	0	A	2227591	G	A	2227591	4	1	48	1	0	0	0	0	0	1	0	0	16724	1153	40	1	104	1	TSR1	17	2227591	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	386982	2227591	78967619	3541	7935										
PAFAH1B1	5048	broad.mit.edu	37	chr17	2573541	2573541	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatttcattcgaccacagcGgcaagcttctggcttcctgt	8	13	2	0	rs121434487		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:2573541G>A	ENST00000397195.5	+	6	935	c.484G>A	c.(484-486)Ggc>Agc	p.G162S	PAFAH1B1_ENST00000397193.3_3'UTR	NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	162	Interaction with dynein and dynactin.		G -> S (in LIS1; dbSNP:rs28936410).		acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						CGACCACAGCGGCAAGCTTCT	0.448													40	107					0	0	1	0	0	A	2573541	G	A	2573541	3	1	48	1	0	0	0	0	1	0	0	0	11430	1116	39	1	502	1	PAFAH1B1	17	2573541	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	345950	2573541	78621669	3542	7936										
CAMKK1	84254	broad.mit.edu	37	chr17	3773125	3773125	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcaccccaattctcgtctcGggattcttgtctaacatctt	7	13	5	0	rs147240137		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:3773125G>A	ENST00000381771.2	-	14	1443	c.1296C>T	c.(1294-1296)ccC>ccT	p.P432P	CAMKK1_ENST00000348335.2_Silent_p.P394P|CAMKK1_ENST00000158166.5_Silent_p.P432P|CAMKK1_ENST00000381769.2_Silent_p.P421P			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	394					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TTCTCGTCTCGGGATTCTTGT	0.572													21	76					0	0	1	0	0	A	3773125	G	A	3773125	2	1	48	1	0	0	0	0	0	0	0	1	2624	1103	39	1		1	CAMKK1	17	3773125	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1199584	3773125	77422085	3543	7937										
ZZEF1	23140	broad.mit.edu	37	chr17	3974124	3974124	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgtatgaatcctttgaaaAgttctgaatatggcccacag	8	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:3974124A>C	ENST00000381638.2	-	26	4053	c.3929T>G	c.(3928-3930)cTt>cGt	p.L1310R		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1310							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TCCTTTGAAAAGTTCTGAATA	0.463													30	67					0	0	1	0	0	C	3974124	A	C	3974124	3	2	48	1	0	0	0	0	1	0	0	0	18294	72	3	4	5076	4	ZZEF1	17	3974124	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	200999	3974124	77221086	3544	7938										
UBE2G1	7326	broad.mit.edu	37	chr17	4210374	4210374	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcggtagagatcattgtcatCtattaaacctgcagaaaagc	8	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:4210374C>T	ENST00000396981.2	-	2	256	c.91G>A	c.(91-93)Gat>Aat	p.D31N	UBE2G1_ENST00000572484.1_5'UTR	NM_003342.4	NP_003333.1	P62253	UB2G1_HUMAN	ubiquitin-conjugating enzyme E2G 1	31					protein K48-linked ubiquitination|protein K63-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			large_intestine(2)|lung(4)|skin(1)	7						TCATTGTCATCTATTAAACCT	0.353													23	30					0	0	1	0	0	T	4210374	C	T	4210374	3	4	48	1	0	0	0	0	1	0	0	0	16916	913	32	3	437	3	UBE2G1	17	4210374	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	236250	4210374	76984836	3545	7939										
PELP1	27043	broad.mit.edu	37	chr17	4576196	4576196	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggaggtccagggcgtgccGagggcacagggcctgctgag	20	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:4576196G>A	ENST00000301396.4	-	16	2747	c.2522C>T	c.(2521-2523)tCg>tTg	p.S841L	PELP1_ENST00000269230.7_Missense_Mutation_p.S607L|PELP1_ENST00000572293.1_Missense_Mutation_p.S747L|PELP1_ENST00000436683.2_Missense_Mutation_p.S550L|PELP1_ENST00000574876.1_Missense_Mutation_p.S697L			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	697	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding	p.S747L(2)|p.S841L(1)		breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						AGGGCGTGCCGAGGGCACAGG	0.677													25	37					0	0	1	0	0	A	4576196	G	A	4576196	3	1	48	1	0	0	0	0	1	0	0	0	11771	1059	37	1	1310	1	PELP1	17	4576196	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	365822	4576196	76619014	3546	7940										
CAMTA2	23125	broad.mit.edu	37	chr17	4873207	4873207	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcccctgaccttgtactttCggaaggccgtctggatgact	11	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:4873207C>T	ENST00000361571.5	-	17	3587	c.3176G>A	c.(3175-3177)cGa>cAa	p.R1059Q	CAMTA2_ENST00000572543.1_Missense_Mutation_p.R1065Q|CAMTA2_ENST00000414043.3_Missense_Mutation_p.R1083Q|CAMTA2_ENST00000358183.4_Missense_Mutation_p.R1060Q|CAMTA2_ENST00000381311.5_Missense_Mutation_p.R1062Q|CAMTA2_ENST00000348066.3_Missense_Mutation_p.R1060Q	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	1060	IQ 1.				cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						CTTGTACTTTCGGAAGGCCGT	0.547													89	134					0	0	1	0	0	T	4873207	C	T	4873207	3	4	48	1	0	0	0	0	1	0	0	0	2632	884	31	1	503	1	CAMTA2	17	4873207	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	297011	4873207	76322003	3547	7941										
ZFP3	124961	broad.mit.edu	37	chr17	4996205	4996205	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaacttatcatacatcagaGaattcacactggagagaagc	7	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:4996205G>T	ENST00000318833.3	+	2	1742	c.1406G>T	c.(1405-1407)aGa>aTa	p.R469I		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						ATACATCAGAGAATTCACACT	0.428													16	42					5.01169e-05	5.45927e-05	1	1	0	T	4996205	G	T	4996205	3	4	48	1	0	0	0	0	1	0	0	0	17700	942	33	2	1408	2	ZFP3	17	4996205	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	122998	4996205	76199005	3548	7942										
USP6	9098	broad.mit.edu	37	chr17	5064861	5064861	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaatatccattcactctacGagttgtgcagaaagatggga	9	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:5064861G>A	ENST00000574788.1	+	32	5097	c.2867G>A	c.(2866-2868)cGa>cAa	p.R956Q	USP6_ENST00000250066.6_Missense_Mutation_p.R956Q|USP6_ENST00000332776.4_3'UTR|USP6_ENST00000304328.5_Missense_Mutation_p.R639Q			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	956					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TTCACTCTACGAGTTGTGCAG	0.393			T	"COL1A1, CDH11, ZNF9, OMD"	aneurysmal bone cysts								16	36					0	0	1	0	0	A	5064861	G	A	5064861	3	1	48	1	0	0	0	0	1	0	0	0	17145	1058	37	1	2957	1	USP6	17	5064861	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	68656	5064861	76130349	3549	7943										
ZNF594	84622	broad.mit.edu	37	chr17	5085278	5085278	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgattacaccaataaactttCttttcctggtgagttctctg	6	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:5085278C>A	ENST00000399604.4	-	1	2414	c.2274G>T	c.(2272-2274)aaG>aaT	p.K758N	ZNF594_ENST00000575779.1_Missense_Mutation_p.K758N			Q96JF6	ZN594_HUMAN	zinc finger protein 594	758					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						AATAAACTTTCTTTTCCTGGT	0.418													55	124					2.01807e-28	2.86628e-28	1	1	0	A	5085278	C	A	5085278	3	1	48	1	0	0	0	0	1	0	0	0	18080	912	32	2	153	2	ZNF594	17	5085278	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	20417	5085278	76109932	3550	7944										
MIS12	79003	broad.mit.edu	37	chr17	5392583	5392583	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtacaagactgaattatgtaCtaagcaggcccttcttgcag	9	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:5392583C>A	ENST00000381165.3	+	3	954	c.401C>A	c.(400-402)aCt>aAt	p.T134N	MIS12_ENST00000573759.1_Missense_Mutation_p.T134N	NM_001258217.1|NM_001258219.1|NM_001258220.1|NM_024039.2	NP_001245146.1|NP_001245148.1|NP_001245149.1|NP_076944.1	Q9H081	MIS12_HUMAN	MIS12 kinetochore complex component	134					cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(2)	12						GAATTATGTACTAAGCAGGCC	0.378													10	99					0.0581538	0.0589718	1	1	0	A	5392583	C	A	5392583	3	1	48	1	0	0	0	0	1	0	0	0	9641	565	20	5	403	5	MIS12	17	5392583	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	307305	5392583	75802627	3551	7945										
KIAA0753	9851	broad.mit.edu	37	chr17	6493188	6493188	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacgactacagtagtcaccGatgctgtgctgcatacccgg	10	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:6493188G>A	ENST00000361413.3	-	18	3055	c.2697C>T	c.(2695-2697)atC>atT	p.I899I	KIAA0753_ENST00000572370.1_Silent_p.I600I|KIAA0753_ENST00000589033.1_Silent_p.I355I|KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000542606.1_Silent_p.I600I	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	899						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		AGTAGTCACCGATGCTGTGCT	0.512													20	42					0	0	1	0	0	A	6493188	G	A	6493188	2	1	48	1	0	0	0	0	0	0	0	1	8232	1048	37	1		1	KIAA0753	17	6493188	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1100605	6493188	74702022	3552	7946										
FBXO39	162517	broad.mit.edu	37	chr17	6690193	6690193	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagttgttttacttcaaaaTctgggctttccttgatgtta	8	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:6690193T>G	ENST00000321535.4	+	3	1248	c.1118T>G	c.(1117-1119)aTc>aGc	p.I373S		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	373										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						TACTTCAAAATCTGGGCTTTC	0.463													39	65					0	0	1	0	0	G	6690193	T	G	6690193	3	3	48	1	0	0	0	0	1	0	0	0	5779	1435	50	4	1124	4	FBXO39	17	6690193	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	197005	6690193	74505017	3553	7947										
CLEC10A	10462	broad.mit.edu	37	chr17	6981396	6981396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagatggcagggcccagagCagagacgctgcaggagggac	19	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:6981396C>T	ENST00000576617.1	-	3	373	c.104G>A	c.(103-105)tGc>tAc	p.C35Y	CLEC10A_ENST00000254868.4_Missense_Mutation_p.C35Y|CLEC10A_ENST00000416562.2_Missense_Mutation_p.C35Y|CLEC10A_ENST00000571664.1_Missense_Mutation_p.C35Y			Q8IUN9	CLC10_HUMAN	C-type lectin domain family 10, member A	35			C -> R (in dbSNP:rs90951).		endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						GGGCCCAGAGCAGAGACGCTG	0.622													7	179					0	0	1	0	0	T	6981396	C	T	6981396	3	4	48	1	0	0	0	0	1	0	0	0	3518	710	25	3	883	3	CLEC10A	17	6981396	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	291203	6981396	74213814	3554	7948										
DLG4	1742	broad.mit.edu	37	chr17	7106763	7106763	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttaggccccttgatgagcTtgatctccatgaccttctca	7	13	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7106763T>G	ENST00000399510.2	-	8	1466	c.614A>C	c.(613-615)aAg>aCg	p.K205T	DLG4_ENST00000399506.2_Missense_Mutation_p.K162T|DLG4_ENST00000485100.1_Missense_Mutation_p.K159T|DLG4_ENST00000302955.6_Missense_Mutation_p.K159T	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	162	PDZ 2.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						CTTGATGAGCTTGATCTCCAT	0.602													36	64					0	0	1	0	0	G	7106763	T	G	7106763	3	3	48	1	0	0	0	0	1	0	0	0	4585	1609	56	4	1749	4	DLG4	17	7106763	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	125367	7106763	74088447	3555	7949										
SLC2A4	6517	broad.mit.edu	37	chr17	7186949	7186949	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcctcattggtatcatctCtcagtggcttggaaggttcg	10	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7186949C>A	ENST00000317370.8	+	3	576	c.308C>A	c.(307-309)tCt>tAt	p.S103Y	SLC2A4_ENST00000424875.2_Missense_Mutation_p.S93Y|SLC2A4_ENST00000571308.1_Missense_Mutation_p.S103Y|RP1-4G17.2_ENST00000576271.1_RNA	NM_001042.2	NP_001033.1	P14672	GTR4_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 4	103					carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding			breast(1)|endometrium(3)|large_intestine(7)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17						GGTATCATCTCTCAGTGGCTT	0.617													27	62					1.17739e-12	1.49076e-12	1	1	0	A	7186949	C	A	7186949	3	1	48	1	0	0	0	0	1	0	0	0	14600	913	32	2	318	2	SLC2A4	17	7186949	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	80186	7186949	74008261	3556	7950										
YBX2	51087	broad.mit.edu	37	chr17	7192940	7192940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtaggggcggtttcgtgggCgctggggctcaggccgggaa	21	8	1	0	rs142210139		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7192940C>T	ENST00000007699.5	-	7	1016	c.953G>A	c.(952-954)cGc>cAc	p.R318H		NM_015982.3	NP_057066.2	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	318	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|skin(3)	12						GTTTCGTGGGCGCTGGGGCTC	0.721													15	32					0	0	1	0	0	T	7192940	C	T	7192940	3	4	48	1	0	0	0	0	1	0	0	0	17529	768	27	1	149	1	YBX2	17	7192940	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5991	7192940	74002270	3557	7951										
NEURL4	84461	broad.mit.edu	37	chr17	7219540	7219540	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagtgagggtcaggaggttCtccaagggcagcggaagggg	20	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7219540C>A	ENST00000399464.2	-	29	4606	c.4591G>T	c.(4591-4593)Gaa>Taa	p.E1531*	NEURL4_ENST00000315614.7_Nonsense_Mutation_p.E1529*|RP11-542C16.2_ENST00000575474.1_Intron|NEURL4_ENST00000570460.1_Nonsense_Mutation_p.E1507*	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCAGGAGGTTCTCCAAGGGCA	0.642													19	50					1.33834e-09	1.61283e-09	1	1	0	A	7219540	C	A	7219540	4	1	48	1	0	0	0	0	0	1	0	0	10393	922	32	2	101	2	NEURL4	17	7219540	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	26600	7219540	73975670	3558	7952										
POLR2A	5430	broad.mit.edu	37	chr17	7404318	7404318	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaagaagtctctgggcacGtcagctggctccctggtcca	12	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7404318G>A	ENST00000322644.6	+	12	2340	c.1941G>A	c.(1939-1941)acG>acA	p.T647T		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	647					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ctCTGGGCACGTCAGCTGGCT	0.542													21	43					0	0	1	0	0	A	7404318	G	A	7404318	2	1	48	1	0	0	0	0	0	0	0	1	12261	1132	40	1		1	POLR2A	17	7404318	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	184778	7404318	73790892	3559	7953										
ATP1B2	482	broad.mit.edu	37	chr17	7557947	7557947	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttccaccctcactccaggTcatcaacttctatgcaggag	6	16	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7557947T>C	ENST00000250111.4	+	5	961	c.552_splice	c.e5-1	p.V185_splice		NM_001678.3	NP_001669.3	P14415	AT1B2_HUMAN	ATPase, Na+/K+ transporting, beta 2 polypeptide	185					ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|pancreas(1)	10		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		TCACTCCAGGTCATCAACTTC	0.532													18	136					0	0	1	0	0	C	7557947	T	C	7557947	5	2	48	1	0	0	0	0	0	0	1	0	1132	1681	58	4	572	4	ATP1B2	17	7557947	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	153629	7557947	73637263	3560	7954										
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	8	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7578212G>A	ENST00000420246.2	-	6	769	c.637C>T	c.(637-639)Cga>Tga	p.R213*	TP53_ENST00000455263.2_Nonsense_Mutation_p.R213*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R213*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R213*|TP53_ENST00000445888.2_Nonsense_Mutation_p.R213*|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.R213*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(250)|p.R81*(21)|p.R120*(21)|p.0?(8)|p.?(5)|p.R213G(5)|p.R213fs*35(3)|p.R213fs*34(3)|p.D208_V216delDRNTFRHSV(1)|p.R120G(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R81fs*>11(1)|p.D208fs*1(1)|p.R120fs*35(1)|p.R81G(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	37					0	0	1	0	0	A	7578212	G	A	7578212	4	1	48	1	0	0	0	0	0	1	0	0	16441	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	20265	7578212	73616998	3561	7955										
TP53	7157	broad.mit.edu	37	chr17	7578389	7578389	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accatcgctatctgagcagcGctcatggtgggggcagcgcc	14	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7578389G>A	ENST00000420246.2	-	5	673	c.541C>T	c.(541-543)Cgc>Tgc	p.R181C	TP53_ENST00000455263.2_Missense_Mutation_p.R181C|TP53_ENST00000359597.4_Missense_Mutation_p.R181C|TP53_ENST00000413465.2_Missense_Mutation_p.R181C|TP53_ENST00000445888.2_Missense_Mutation_p.R181C|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000269305.4_Missense_Mutation_p.R181C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	181	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R181C(19)|p.0?(8)|p.P177_C182delPHHERC(8)|p.R174fs*24(3)|p.C176_R181delCPHHER(3)|p.H178_S183delHHERCS(3)|p.P177fs*3(2)|p.R49C(2)|p.R88C(2)|p.V173fs*59(2)|p.C176fs*65(1)|p.R181G(1)|p.H85_S90delHHERCS(1)|p.E180_S183del(1)|p.R174fs*3(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R81fs*24(1)|p.R181>XXXXXXX(1)|p.H46_S51delHHERCS(1)|p.R42fs*24(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGAGCAGCGCTCATGGTGG	0.637		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	44					0	0	1	0	0	A	7578389	G	A	7578389	3	1	48	1	0	0	0	0	1	0	0	0	16441	1087	38	1	757	1	TP53	17	7578389	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	177	7578389	73616821	3562	7956										
WRAP53	55135	broad.mit.edu	37	chr17	7606440	7606440	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaaggactgcaccaatggCgtgaggtcctcagttcaatt	11	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7606440C>T	ENST00000316024.5	+	9	3746	c.1398C>T	c.(1396-1398)ggC>ggT	p.G466G	WRAP53_ENST00000457584.2_Silent_p.G466G|WRAP53_ENST00000396463.2_Silent_p.G466G|WRAP53_ENST00000431639.2_Silent_p.G466G|WRAP53_ENST00000534050.1_Silent_p.G433G			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	466					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						GCACCAATGGCGTGAGGTCCT	0.592													14	48					0	0	1	0	0	T	7606440	C	T	7606440	2	4	48	1	0	0	0	0	0	0	0	1	17459	755	27	1		1	WRAP53	17	7606440	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	28051	7606440	73588770	3563	7957										
DNAH2	146754	broad.mit.edu	37	chr17	7678128	7678128	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcctggaagatattcagaAatctctggatatgtatttag	8	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7678128A>C	ENST00000572933.1	+	29	6013	c.4553A>C	c.(4552-4554)aAa>aCa	p.K1518T	DNAH2_ENST00000389173.2_Missense_Mutation_p.K1518T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1518	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GATATTCAGAAATCTCTGGAT	0.448													26	28					0	0	1	0	0	C	7678128	A	C	7678128	3	2	48	1	0	0	0	0	1	0	0	0	4630	14	1	4	4663	4	DNAH2	17	7678128	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	71688	7678128	73517082	3564	7958										
DNAH2	146754	broad.mit.edu	37	chr17	7678157	7678157	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatgtatttagagaccaagCgacatattttcccccgcttc	6	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7678157C>T	ENST00000572933.1	+	29	6042	c.4582C>T	c.(4582-4584)Cga>Tga	p.R1528*	DNAH2_ENST00000389173.2_Nonsense_Mutation_p.R1528*			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1528	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGAGACCAAGCGACATATTTT	0.463													6	59					0	0	1	0	0	T	7678157	C	T	7678157	4	4	48	1	0	0	0	0	0	1	0	0	4630	760	27	1	4692	1	DNAH2	17	7678157	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29	7678157	73517053	3565	7959										
DNAH2	146754	broad.mit.edu	37	chr17	7707670	7707670	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actagggaaaaggtgcaagtGatgtcgttggagctggagga	17	4	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7707670G>T	ENST00000572933.1	+	59	10529	c.9069G>T	c.(9067-9069)gtG>gtT	p.V3023V	DNAH2_ENST00000389173.2_Silent_p.V3023V			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3023	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGGTGCAAGTGATGTCGTTGG	0.542													23	66					2.32416e-17	3.12201e-17	1	1	0	T	7707670	G	T	7707670	2	4	48	1	0	0	0	0	0	0	0	1	4630	1277	45	2		2	DNAH2	17	7707670	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29513	7707670	73487540	3566	7960										
DNAH2	146754	broad.mit.edu	37	chr17	7733753	7733753	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtgttacttgaacgcaaaAagttcctgcagcttggctgg	11	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7733753A>C	ENST00000572933.1	+	78	13449	c.11989A>C	c.(11989-11991)Aag>Cag	p.K3997Q	DNAH2_ENST00000389173.2_Missense_Mutation_p.K3997Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3997	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGAACGCAAAAAGTTCCTGCA	0.478													35	71					0	0	1	0	0	C	7733753	A	C	7733753	3	2	48	1	0	0	0	0	1	0	0	0	4630	15	1	4	12295	4	DNAH2	17	7733753	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	26083	7733753	73461457	3567	7961										
DNAH2	146754	broad.mit.edu	37	chr17	7735091	7735091	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgttcctccgctctggggaAaggcaagattataccattgt	10	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:7735091A>C	ENST00000572933.1	+	82	14184	c.12724A>C	c.(12724-12726)Aag>Cag	p.K4242Q	DNAH2_ENST00000389173.2_Missense_Mutation_p.K4242Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4242					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCTCTGGGGAAAGGCAAGATT	0.488													13	31					0	0	1	0	0	C	7735091	A	C	7735091	3	2	48	1	0	0	0	0	1	0	0	0	4630	15	1	4	13046	4	DNAH2	17	7735091	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1338	7735091	73460119	3568	7962										
MYH10	4628	broad.mit.edu	37	chr17	8508286	8508286	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtttataactacacagaaGagtccagaataagtctagaa	9	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:8508286G>T	ENST00000360416.3	-	3	498	c.360C>A	c.(358-360)ctC>ctA	p.L120L	MYH10_ENST00000396239.1_Silent_p.L120L|MYH10_ENST00000379980.4_Silent_p.L120L|MYH10_ENST00000269243.4_Silent_p.L120L	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	120	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CTACACAGAAGAGTCCAGAAT	0.343													10	23					0.000442599	0.00046913	1	1	0	T	8508286	G	T	8508286	2	4	48	1	0	0	0	0	0	0	0	1	10077	929	33	2		2	MYH10	17	8508286	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	773195	8508286	72686924	3569	7963										
MYH13	8735	broad.mit.edu	37	chr17	10206514	10206514	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggacctcctgtgcttaccGcctcctcagcctgcctcttg	10	17	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:10206514G>A	ENST00000418404.3	-	38	5829	c.5667_splice	c.e38+1	p.A1889_splice	MYH13_ENST00000252172.4_Splice_Site_p.A1889_splice|MYH13_ENST00000570743.1_Splice_Site_p.A1889_splice			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1889					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TGTGCTTACCGCCTCCTCAGC	0.597													62	119					0	0	1	0	0	A	10206514	G	A	10206514	5	1	48	1	0	0	0	0	0	0	1	0	10079	1101	38	1	162	1	MYH13	17	10206514	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1698228	10206514	70988696	3570	7964										
MYH1	4619	broad.mit.edu	37	chr17	10402095	10402095	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttcccgcagcaggtcacaGtcatggcgggaggactgcag	15	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:10402095G>T	ENST00000226207.5	-	30	4123	c.4029C>A	c.(4027-4029)gaC>gaA	p.D1343E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1343						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GCAGGTCACAGTCATGGCGGG	0.507													31	54					1.68508e-10	2.06928e-10	1	1	0	T	10402095	G	T	10402095	3	4	48	1	0	0	0	0	1	0	0	0	10076	1020	36	5	1834	5	MYH1	17	10402095	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	195581	10402095	70793115	3571	7965										
MYH2	4620	broad.mit.edu	37	chr17	10427885	10427885	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtggcccgcagctcctcGatctcagcctgcagcaggtt	12	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:10427885G>A	ENST00000245503.5	-	35	5457	c.5073C>T	c.(5071-5073)atC>atT	p.I1691I	MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Silent_p.I1691I|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1691					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCAGCTCCTCGATCTCAGCCT	0.592													26	58					0	0	1	0	0	A	10427885	G	A	10427885	2	1	48	1	0	0	0	0	0	0	0	1	10082	1048	37	1		1	MYH2	17	10427885	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25790	10427885	70767325	3572	7966										
MYH2	4620	broad.mit.edu	37	chr17	10441078	10441078	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tactcctcctgctccagcacGaacatgtggtggttgaaaaa	9	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:10441078G>A	ENST00000245503.5	-	15	1875	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	MYH2_ENST00000532183.1_Silent_p.F497F|MYH2_ENST00000397183.2_Silent_p.F497F|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	497	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCTCCAGCACGAACATGTGGT	0.478													52	106					0	0	1	0	0	A	10441078	G	A	10441078	2	1	48	1	0	0	0	0	0	0	0	1	10082	1049	37	1		1	MYH2	17	10441078	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13193	10441078	70754132	3573	7967										
MYH2	4620	broad.mit.edu	37	chr17	10447242	10447242	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattttgccagaagtaatttCttccttcttcttctcaccag	4	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:10447242C>A	ENST00000245503.5	-	7	1009	c.625G>T	c.(625-627)Gaa>Taa	p.E209*	MYH2_ENST00000532183.1_Nonsense_Mutation_p.E209*|MYH2_ENST00000397183.2_Nonsense_Mutation_p.E209*|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	209	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GAAGTAATTTCTTCCTTCTTC	0.458													22	38					8.10497e-08	9.43176e-08	1	1	0	A	10447242	C	A	10447242	4	1	48	1	0	0	0	0	0	1	0	0	10082	922	32	2	5336	2	MYH2	17	10447242	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6164	10447242	70747968	3574	7968										
DNAH9	1770	broad.mit.edu	37	chr17	11573031	11573031	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaaaattgatattcgaccCtttaaggcatctctgctgaa	7	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:11573031C>A	ENST00000262442.3	+	17	3341	c.3273C>A	c.(3271-3273)ccC>ccA	p.P1091P	DNAH9_ENST00000454412.2_Silent_p.P1091P	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1091	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ATATTCGACCCTTTAAGGCAT	0.443													18	119					1.45105e-14	1.8931e-14	1	1	0	A	11573031	C	A	11573031	2	1	48	1	0	0	0	0	0	0	0	1	4635	668	24	5		5	DNAH9	17	11573031	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1125789	11573031	69622179	3575	7969										
DNAH9	1770	broad.mit.edu	37	chr17	11593429	11593429	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggacaaagctgcaaaagaGatgggtatggagaaaacctt	13	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:11593429G>T	ENST00000262442.3	+	20	4358	c.4290G>T	c.(4288-4290)gaG>gaT	p.E1430D	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1430D	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1430	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGCAAAAGAGATGGGTATGG	0.562													19	38					7.07596e-05	7.68259e-05	1	1	0	T	11593429	G	T	11593429	3	4	48	1	0	0	0	0	1	0	0	0	4635	933	33	2	4368	2	DNAH9	17	11593429	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	20398	11593429	69601781	3576	7970										
MAP2K4	6416	broad.mit.edu	37	chr17	11984700	11984700	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgagaacacacagcattgaGtcatcaggaaaactgaagat	9	8	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:11984700G>A	ENST00000415385.3	+	4	332	c.279G>A	c.(277-279)gaG>gaA	p.E93E	MAP2K4_ENST00000353533.5_Silent_p.E82E			P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	82					cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.0?(10)|p.?(1)		NS(1)|biliary_tract(2)|breast(22)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(26)|lung(15)|ovary(8)|pancreas(11)|skin(3)|stomach(2)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	100		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		ACAGCATTGAGTCATCAGGAA	0.378			"D, Mis, N"		"pancreatic, breast, colorectal"								21	30					0	0	1	0	0	A	11984700	G	A	11984700	2	1	48	1	0	0	0	0	0	0	0	1	9288	1020	36	3		3	MAP2K4	17	11984700	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	391271	11984700	69210510	3577	7971										
MAP2K4	6416	broad.mit.edu	37	chr17	11998922	11998923	+	Frame_Shift_Ins	INS	-	-	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacagtggatgaaaaagaacINSaaaaacaacttcttatggat							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:11998922_11998923insA	ENST00000415385.3	+	5	510_511	c.457_458insA	c.(457-459)aaafs	p.K153fs	MAP2K4_ENST00000353533.5_Frame_Shift_Ins_p.K142fs			P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	142	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.0?(10)|p.Q142L(1)|p.?(1)		NS(1)|biliary_tract(2)|breast(22)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(26)|lung(15)|ovary(8)|pancreas(11)|skin(3)|stomach(2)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	100		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		TGAAAAAGAACAAAAACAACTT	0.337			"D, Mis, N"		"pancreatic, breast, colorectal"								19	52	---	---	---	---						A	11998923	-	A	11998922	7	5	48	1	0	1	1	0	0	0	0	0	9288	479	17	0	438	0	MAP2K4	17	11998922	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	14222	11998922	69196288	3578	7972										
HS3ST3A1	9955	broad.mit.edu	37	chr17	13504372	13504372	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggagcagagcatcagcaaGaacttccggaagatgctgcg	14	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:13504372G>T	ENST00000284110.1	-	1	872	c.75C>A	c.(73-75)ttC>ttA	p.F25L		NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	25						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCATCAGCAAGAACTTCCGGA	0.697													4	12					0.150653	0.151842	1	1	0	T	13504372	G	T	13504372	3	4	48	1	0	0	0	0	1	0	0	0	7405	933	33	2	1153	2	HS3ST3A1	17	13504372	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1505450	13504372	67690838	3579	7973										
ZNF286A	57335	broad.mit.edu	37	chr17	15620126	15620126	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taatgaatgtgataaagcttTtattcattcatcagcactca	5	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:15620126T>G	ENST00000464847.2	+	5	1641	c.1088T>G	c.(1087-1089)tTt>tGt	p.F363C	ZNF286A_ENST00000583566.1_Missense_Mutation_p.F363C|ZNF286A_ENST00000593105.1_Missense_Mutation_p.F353C|ZNF286A_ENST00000585171.1_Intron|ZNF286A_ENST00000421016.1_Missense_Mutation_p.F363C|ZNF286A_ENST00000413242.2_Missense_Mutation_p.F363C|ZNF286A_ENST00000395894.2_3'UTR			Q9HBT8	Z286A_HUMAN	zinc finger protein 286A	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GATAAAGCTTTTATTCATTCA	0.368													9	30					0	0	1	0	0	G	15620126	T	G	15620126	3	3	48	1	0	0	0	0	1	0	0	0	17880	1841	64	4	1106	4	ZNF286A	17	15620126	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2115754	15620126	65575084	3580	7974										
ZNF286A	57335	broad.mit.edu	37	chr17	15620411	15620411	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caattttgctaaacatcaaaGaattcatattggaaagaaac	5	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:15620411G>T	ENST00000464847.2	+	5	1926	c.1373G>T	c.(1372-1374)aGa>aTa	p.R458I	ZNF286A_ENST00000583566.1_Missense_Mutation_p.R458I|ZNF286A_ENST00000593105.1_Missense_Mutation_p.R448I|ZNF286A_ENST00000585171.1_Intron|ZNF286A_ENST00000421016.1_Missense_Mutation_p.R458I|ZNF286A_ENST00000413242.2_Missense_Mutation_p.R458I|ZNF286A_ENST00000395894.2_3'UTR			Q9HBT8	Z286A_HUMAN	zinc finger protein 286A	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R458I(1)		central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		AAACATCAAAGAATTCATATT	0.408													19	26					2.4624e-09	2.95225e-09	1	1	0	T	15620411	G	T	15620411	3	4	48	1	0	0	0	0	1	0	0	0	17880	942	33	2	1391	2	ZNF286A	17	15620411	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	285	15620411	65574799	3581	7975										
ZNF624	57547	broad.mit.edu	37	chr17	16527311	16527311	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtttttctttagtatgagTtctttgatgttgaatgagca	10	3	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:16527311T>C	ENST00000311331.7	-	6	980	c.889A>G	c.(889-891)Act>Gct	p.T297A		NM_020787.3	NP_065838.2	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	26				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTAGTATGAGTTCTTTGATGT	0.343													21	51					0	0	1	0	0	C	16527311	T	C	16527311	3	2	48	1	0	0	0	0	1	0	0	0	18104	1725	60	4	1712	4	ZNF624	17	16527311	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	906900	16527311	64667899	3582	7976										
CCDC144A	9720	broad.mit.edu	37	chr17	16612833	16612833	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagattctgacagaacatcaGaagtatatctacatgaagaa	7	7	3	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:16612833G>T	ENST00000443444.2	+	5	1602	c.1462G>T	c.(1462-1464)Gaa>Taa	p.E488*	CCDC144A_ENST00000360524.8_Nonsense_Mutation_p.E488*|CCDC144A_ENST00000340621.5_Nonsense_Mutation_p.E487*|CCDC144A_ENST00000456009.1_Intron|RP11-219A15.1_ENST00000448331.3_Nonsense_Mutation_p.E488*|CCDC144A_ENST00000399273.1_Nonsense_Mutation_p.E488*			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	488																	CAGAACATCAGAAGTATATCT	0.353													20	47					1.00905e-13	1.29777e-13	1	1	0	T	16612833	G	T	16612833	4	4	48	1	0	0	0	0	0	1	0	0	2795	943	33	2	1480	2	CCDC144A	17	16612833	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	85522	16612833	64582377	3583	7977										
COPS3	8533	broad.mit.edu	37	chr17	17179423	17179423	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtccagatgggataagttCttcgcaaggagttccccact	11	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:17179423C>A	ENST00000539941.2	-	2	259	c.51G>T	c.(49-51)aaG>aaT	p.K17N	COPS3_ENST00000439936.2_Missense_Mutation_p.K17N|COPS3_ENST00000268717.5_Missense_Mutation_p.K37N	NM_001199125.1	NP_001186054.1	Q9UNS2	CSN3_HUMAN	COP9 signalosome subunit 3	37					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			NS(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						GGGATAAGTTCTTCGCAAGGA	0.458													20	45					5.35267e-07	6.09026e-07	1	1	0	A	17179423	C	A	17179423	3	1	48	1	0	0	0	0	1	0	0	0	3757	912	32	2	1204	2	COPS3	17	17179423	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	566590	17179423	64015787	3584	7978										
LRRC48	83450	broad.mit.edu	37	chr17	17909551	17909551	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatggtaggactgtttatcGaaaatgtccaaagcctatat	8	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:17909551G>A	ENST00000313838.8	+	12	1565	c.1186G>A	c.(1186-1188)Gaa>Aaa	p.E396K	LRRC48_ENST00000584166.1_Missense_Mutation_p.E396K|LRRC48_ENST00000411504.2_Missense_Mutation_p.E396K|LRRC48_ENST00000399182.1_Missense_Mutation_p.E396K|LRRC48_ENST00000399187.1_Missense_Mutation_p.E396K	NM_001130090.1	NP_001123562.1	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48	396						cytoplasm				breast(1)|large_intestine(2)|lung(2)|pancreas(1)|urinary_tract(1)	7	all_neural(463;0.228)					ACTGTTTATCGAAAATGTCCA	0.433													4	12					0	0	1	0	0	A	17909551	G	A	17909551	3	1	48	1	0	0	0	0	1	0	0	0	9049	1059	37	1	1220	1	LRRC48	17	17909551	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	730128	17909551	63285659	3585	7979										
TBC1D28	254272	broad.mit.edu	37	chr17	18539887	18539887	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatatgcagaataggccacgAggatgtcacataattcctgc	9	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:18539887A>C	ENST00000345096.4	-	9	1220	c.521T>G	c.(520-522)cTc>cGc	p.L174R	TBC1D28_ENST00000405044.1_Missense_Mutation_p.L174R			Q2M2D7	TBC28_HUMAN	TBC1 domain family, member 28	174	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|large_intestine(5)|lung(2)|ovary(1)	9						ATAGGCCACGAGGATGTCACA	0.463													16	138					0	0	1	0	0	C	18539887	A	C	18539887	3	2	48	1	0	0	0	0	1	0	0	0	15673	304	11	4	115	4	TBC1D28	17	18539887	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	630336	18539887	62655323	3586	7980										
MAP2K3	5606	broad.mit.edu	37	chr17	21202199	21202199	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctccacagacccccccgGaacctggactcccggacctt	7	19	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:21202199G>A	ENST00000342679.4	+	3	375	c.126G>A	c.(124-126)cgG>cgA	p.R42R	MAP2K3_ENST00000316920.6_Silent_p.R13R|MAP2K3_ENST00000361818.5_Silent_p.R13R	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	42					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GACCCCCCCGGAACCTGGACT	0.622													6	95					0	0	1	0	0	A	21202199	G	A	21202199	2	1	48	1	0	0	0	0	0	0	0	1	9287	1161	41	3		3	MAP2K3	17	21202199	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2662312	21202199	59993011	3587	7981										
KCNJ12	3768	broad.mit.edu	37	chr17	21319491	21319491	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagattgacgaggccagcccGctcttcggcatcagccggca	13	14	2	2	rs111560549	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:21319491G>A	ENST00000583088.1	+	3	1732	c.837G>A	c.(835-837)ccG>ccA	p.P279P	KCNJ12_ENST00000331718.5_Silent_p.P279P	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		AGGCCAGCCCGCTCTTCGGCA	0.607										Prostate(3;0.18)			24	91					0	0	1	0	0	A	21319491	G	A	21319491	2	1	48	1	0	0	0	0	0	0	0	1	8089	1074	38	1		1	KCNJ12	17	21319491	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	117292	21319491	59875719	3588	7982										
WSB1	26118	broad.mit.edu	37	chr17	25639387	25639387	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttggagtttctctcgtatCgtatttagaagattctgcct	8	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:25639387C>T	ENST00000262394.2	+	9	1574	c.1258C>T	c.(1258-1260)Cgt>Tgt	p.R420C	WSB1_ENST00000348811.2_Missense_Mutation_p.R274C	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	420	SOCS box.				intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TCTCTCGTATCGTATTTAGAA	0.423													86	151					0	0	1	0	0	T	25639387	C	T	25639387	3	4	48	1	0	0	0	0	1	0	0	0	17463	884	31	1	1292	1	WSB1	17	25639387	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4319896	25639387	55555823	3589	7983										
NOS2	4843	broad.mit.edu	37	chr17	26109077	26109077	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtggagtaacgcacgtgtCtgcagatgtgttcaaacatt	12	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:26109077C>A	ENST00000313735.6	-	7	919	c.686G>T	c.(685-687)aGa>aTa	p.R229I		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	229					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ACGCACGTGTCTGCAGATGTG	0.542													5	39					1.23904e-05	1.36503e-05	1	1	0	A	26109077	C	A	26109077	3	1	48	1	0	0	0	0	1	0	0	0	10589	913	32	2	2859	2	NOS2	17	26109077	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	469690	26109077	55086133	3590	7984										
NOS2	4843	broad.mit.edu	37	chr17	26114738	26114738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaatattggttgacaaattCgatagcttgaggtagaagct	11	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:26114738C>T	ENST00000313735.6	-	5	666	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	145					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TTGACAAATTCGATAGCTTGA	0.527													50	81					0	0	1	0	0	T	26114738	C	T	26114738	3	4	48	1	0	0	0	0	1	0	0	0	10589	893	31	1	3120	1	NOS2	17	26114738	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5661	26114738	55080472	3591	7985										
VTN	7448	broad.mit.edu	37	chr17	26696426	26696426	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaggcctcactgccttttCgtccagttcatagcagtact	7	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:26696426C>T	ENST00000226218.4	-	4	1171	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	SARM1_ENST00000379061.4_Intron|SEBOX_ENST00000536498.1_5'UTR|CTB-96E2.3_ENST00000591482.1_RNA|TMEM199_ENST00000509083.1_Intron	NM_000638.3	NP_000629.3	P04004	VTNC_HUMAN	vitronectin	185	Hemopexin-like 1.				cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity	p.E185K(1)		kidney(2)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	13	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	ACTGCCTTTTCGTCCAGTTCA	0.607													32	69					0	0	1	0	0	T	26696426	C	T	26696426	3	4	48	1	0	0	0	0	1	0	0	0	17296	893	31	1	903	1	VTN	17	26696426	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	581688	26696426	54498784	3592	7986										
PIGS	94005	broad.mit.edu	37	chr17	26890915	26890915	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctggaaacggcatttgatTttcattttgtctgggaggga	12	5	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:26890915T>G	ENST00000308360.7	-	4	672	c.297A>C	c.(295-297)aaA>aaC	p.K99N	PIGS_ENST00000543734.1_Missense_Mutation_p.K38N|PIGS_ENST00000395346.2_Missense_Mutation_p.K91N	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	99					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					GGCATTTGATTTTCATTTTGT	0.522													4	124					0	0	1	0	0	G	26890915	T	G	26890915	3	3	48	1	0	0	0	0	1	0	0	0	11945	1838	64	4	1406	4	PIGS	17	26890915	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	194489	26890915	54304295	3593	7987										
RAB34	83871	broad.mit.edu	37	chr17	27041840	27041840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccaatgcgtcgagcccccGatttctccagctcagccagc	8	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:27041840G>A	ENST00000395245.3	-	9	1309	c.683C>T	c.(682-684)tCg>tTg	p.S228L	RAB34_ENST00000301043.6_Missense_Mutation_p.S228L|RAB34_ENST00000395242.2_Missense_Mutation_p.S229L|RAB34_ENST00000450529.1_Missense_Mutation_p.S220L|RAB34_ENST00000453384.3_Intron|RAB34_ENST00000436730.3_Missense_Mutation_p.S228L|RAB34_ENST00000395243.3_Missense_Mutation_p.S220L|RAB34_ENST00000447716.1_Missense_Mutation_p.S285L|RAB34_ENST00000415040.2_Missense_Mutation_p.S206L	NM_001256281.1|NM_031934.5	NP_001243210.1|NP_114140.4	Q9BZG1	RAB34_HUMAN	RAB34, member RAS oncogene family	228					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding			endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|skin(2)	14	Lung NSC(42;0.00431)					TCGAGCCCCCGATTTCTCCAG	0.547													25	58					0	0	1	0	0	A	27041840	G	A	27041840	3	1	48	1	0	0	0	0	1	0	0	0	12975	1059	37	1	168	1	RAB34	17	27041840	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	150925	27041840	54153370	3594	7988										
NUFIP2	57532	broad.mit.edu	37	chr17	27620866	27620866	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctgctcatgtttcagcggcTttggctgggccttggggctg	15	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:27620866T>G	ENST00000225388.4	-	1	270	c.212A>C	c.(211-213)aAg>aCg	p.K71T	NUFIP2_ENST00000579665.1_Missense_Mutation_p.K71T	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	71						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			TTTCAGCGGCTTTGGCTGGGC	0.597													9	201					0	0	1	0	0	G	27620866	T	G	27620866	3	3	48	1	0	0	0	0	1	0	0	0	10796	1609	56	4	1891	4	NUFIP2	17	27620866	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	579026	27620866	53574344	3595	7989										
SSH2	85464	broad.mit.edu	37	chr17	27959445	27959445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcattctttgaattcttacGagtggacaatgaggtacatg	9	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:27959445G>A	ENST00000269033.3	-	15	2837	c.2686C>T	c.(2686-2688)Cgt>Tgt	p.R896C	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.R923C	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	896					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAATTCTTACGAGTGGACAAT	0.512													76	138					0	0	1	0	0	A	27959445	G	A	27959445	3	1	48	1	0	0	0	0	1	0	0	0	15240	1058	37	1	1589	1	SSH2	17	27959445	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	338579	27959445	53235765	3596	7990										
SSH2	85464	broad.mit.edu	37	chr17	28003889	28003889	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgaactctgttatccgtcGatacactgaacccactaagg	8	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:28003889G>A	ENST00000269033.3	-	7	633	c.482C>T	c.(481-483)tCg>tTg	p.S161L	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.S188L|SSH2_ENST00000324677.7_5'UTR	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	161					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTTATCCGTCGATACACTGAA	0.368													11	33					0	0	1	0	0	A	28003889	G	A	28003889	3	1	48	1	0	0	0	0	1	0	0	0	15240	1059	37	1	3825	1	SSH2	17	28003889	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	44444	28003889	53191321	3597	7991										
EFCAB5	374786	broad.mit.edu	37	chr17	28405274	28405274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagccacaccctggtcacGaagtgagattgtcttcaaaa	8	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:28405274G>A	ENST00000394835.3	+	15	2971	c.2779G>A	c.(2779-2781)Gaa>Aaa	p.E927K	EFCAB5_ENST00000320856.5_Missense_Mutation_p.E803K|EFCAB5_ENST00000394832.2_Intron	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	927							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CCCTGGTCACGAAGTGAGATT	0.413													18	47					0	0	1	0	0	A	28405274	G	A	28405274	3	1	48	1	0	0	0	0	1	0	0	0	4964	1059	37	1	3004	1	EFCAB5	17	28405274	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	401385	28405274	52789936	3598	7992										
EFCAB5	374786	broad.mit.edu	37	chr17	28414099	28414099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggattcagactatgttttaCgcaacatgatggttacaggg	11	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:28414099C>T	ENST00000394835.3	+	19	3790	c.3598C>T	c.(3598-3600)Cgc>Tgc	p.R1200C	EFCAB5_ENST00000320856.5_Missense_Mutation_p.R1076C|EFCAB5_ENST00000394832.2_Intron	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1200							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CTATGTTTTACGCAACATGAT	0.393													17	40					0	0	1	0	0	T	28414099	C	T	28414099	3	4	48	1	0	0	0	0	1	0	0	0	4964	536	19	1	3839	1	EFCAB5	17	28414099	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8825	28414099	52781111	3599	7993										
EFCAB5	374786	broad.mit.edu	37	chr17	28417440	28417440	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttggttttgatttcagaGatttcctctttaaatgtact	6	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:28417440G>A	ENST00000394835.3	+	20	3877	c.3683_splice	c.e20-1	p.D1229_splice	EFCAB5_ENST00000320856.5_Splice_Site_p.D1105_splice|EFCAB5_ENST00000394832.2_Intron|RP11-1148O4.2_ENST00000582938.1_RNA	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1229							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						TGATTTCAGAGATTTCCTCTT	0.398													18	29					0	0	1	0	0	A	28417440	G	A	28417440	5	1	48	1	0	0	0	0	0	0	1	0	4964	956	33	3	3930	3	EFCAB5	17	28417440	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3341	28417440	52777770	3600	7994										
CPD	1362	broad.mit.edu	37	chr17	28776572	28776572	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttctggtttttgaaagtTtgggacagagcactgaatat	11	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:28776572T>G	ENST00000225719.4	+	13	2951	c.2873_splice	c.e13-1	p.L959_splice	CPD_ENST00000543464.2_Splice_Site_p.L712_splice	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	959	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						TTTTGAAAGTTTGGGACAGAG	0.348													8	70					0	0	1	0	0	G	28776572	T	G	28776572	5	3	48	1	0	0	0	0	0	0	1	0	3821	1855	64	4	2925	4	CPD	17	28776572	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	359132	28776572	52418638	3601	7995										
ATAD5	79915	broad.mit.edu	37	chr17	29162582	29162582	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggggctattccaggcaaaAacagagagggaaacactcaa	11	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:29162582A>C	ENST00000321990.4	+	2	1861	c.1483A>C	c.(1483-1485)Aac>Cac	p.N495H	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	495					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCCAGGCAAAAACAGAGAGGG	0.308													23	45					0	0	1	0	0	C	29162582	A	C	29162582	3	2	48	1	0	0	0	0	1	0	0	0	1075	14	1	4	1489	4	ATAD5	17	29162582	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	386010	29162582	52032628	3602	7996										
ATAD5	79915	broad.mit.edu	37	chr17	29220402	29220402	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagattttttatatagtaatCttgagtttattctaccatta	4	4	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:29220402C>A	ENST00000321990.4	+	21	4909	c.4531C>A	c.(4531-4533)Ctt>Att	p.L1511I		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1511					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ATATAGTAATCTTGAGTTTAT	0.348													27	68					3.73808e-20	5.11168e-20	1	1	0	A	29220402	C	A	29220402	3	1	48	1	0	0	0	0	1	0	0	0	1075	913	32	2	4613	2	ATAD5	17	29220402	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	57820	29220402	51974808	3603	7997										
ADAP2	55803	broad.mit.edu	37	chr17	29253886	29253886	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccgtgtgaaggccaagttCgaagccagagtcccagcttt	11	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:29253886C>T	ENST00000330889.3	+	3	602	c.267C>T	c.(265-267)ttC>ttT	p.F89F	ADAP2_ENST00000580525.1_Silent_p.F95F	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	89	Arf-GAP.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)|p.F89F(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						AGGCCAAGTTCGAAGCCAGAG	0.488													19	43					0	0	1	0	0	T	29253886	C	T	29253886	2	4	48	1	0	0	0	0	0	0	0	1	279	883	31	1		1	ADAP2	17	29253886	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	33484	29253886	51941324	3604	7998										
ADAP2	55803	broad.mit.edu	37	chr17	29261312	29261312	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaagtacttcacaaaggaAcaggtaagatgccagaccaa	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:29261312A>G	ENST00000330889.3	+	5	842	c.507A>G	c.(505-507)gaA>gaG	p.E169E	ADAP2_ENST00000580525.1_Silent_p.E175E	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	169	PH 1.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						TCACAAAGGAACAGGTAAGAT	0.473													9	22					0	0	1	0	0	G	29261312	A	G	29261312	2	3	48	1	0	0	0	0	0	0	0	1	279	40	2	4		4	ADAP2	17	29261312	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	7426	29261312	51933898	3605	7999										
NF1	4763	broad.mit.edu	37	chr17	29684049	29684049	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtgtctgaatcaaatgttCtcttggatgaagaagtactt	9	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:29684049C>A	ENST00000358273.4	+	53	8193	c.7810C>A	c.(7810-7812)Ctc>Atc	p.L2604I	NF1_ENST00000417592.2_3'UTR|NF1_ENST00000444181.2_Missense_Mutation_p.L397I|NF1_ENST00000356175.3_Missense_Mutation_p.L2583I	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2604					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATCAAATGTTCTCTTGGATGA	0.423			"D, Mis, N, F, S, O"		"neurofibroma, glioma"	"neurofibroma, glioma"			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			46	90					7.05121e-23	9.83114e-23	1	1	0	A	29684049	C	A	29684049	3	1	48	1	0	0	0	0	1	0	0	0	10402	913	32	2	8081	2	NF1	17	29684049	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	422737	29684049	51511161	3606	8000										
CCT6B	10693	broad.mit.edu	37	chr17	33269503	33269503	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctaaactttctttctcacCttttgattaatgacgacaaa	3	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:33269503C>A	ENST00000314144.5	-	7	1000	c.885_splice	c.e7+1	p.K295_splice	CCT6B_ENST00000421975.3_Splice_Site_p.K258_splice|CCT6B_ENST00000436961.3_Splice_Site_p.K250_splice	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	295					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TCTTTCTCACCTTTTGATTAA	0.323													10	13					1.76689e-08	2.08373e-08	1	1	0	A	33269503	C	A	33269503	5	1	48	1	0	0	0	0	0	0	1	0	2980	695	24	5	739	5	CCT6B	17	33269503	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3585454	33269503	47925707	3607	8001										
SLFN11	91607	broad.mit.edu	37	chr17	33679887	33679887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctattggatctgcattgcGaactattctggtgagctctt	11	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:33679887G>A	ENST00000394566.1	-	7	2466	c.2194C>T	c.(2194-2196)Cgc>Tgc	p.R732C	SLFN11_ENST00000308377.4_Missense_Mutation_p.R732C	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	732						nucleus	ATP binding	p.R732C(1)		autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCTGCATTGCGAACTATTCTG	0.443													46	92					0	0	1	0	0	A	33679887	G	A	33679887	3	1	48	1	0	0	0	0	1	0	0	0	14787	1058	37	1	515	1	SLFN11	17	33679887	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	410384	33679887	47515323	3608	8002										
SLFN11	91607	broad.mit.edu	37	chr17	33690361	33690361	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccaagatttttggcttccTtttggtcttcaggaaacaga	8	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:33690361T>G	ENST00000394566.1	-	4	738	c.466A>C	c.(466-468)Agg>Cgg	p.R156R	SLFN11_ENST00000308377.4_Silent_p.R156R	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	156						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTTGGCTTCCTTTTGGTCTTC	0.483													38	72					0	0	1	0	0	G	33690361	T	G	33690361	2	3	48	1	0	0	0	0	0	0	0	1	14787	1608	56	4		4	SLFN11	17	33690361	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	10474	33690361	47504849	3609	8003										
TAF15	8148	broad.mit.edu	37	chr17	34163181	34163181	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacacaatctttgtgcaagGacttggggagggtgtgtcta	13	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:34163181G>T	ENST00000588240.1	+	10	834	c.719G>T	c.(718-720)gGa>gTa	p.G240V	TAF15_ENST00000311979.3_Missense_Mutation_p.G237V|TAF15_ENST00000592237.1_Missense_Mutation_p.G149V	NM_003487.3|NM_139215.2	NP_003478.1|NP_631961.1	Q92804	RBP56_HUMAN	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	240	RRM.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	lung(1)|ovary(1)|skin(2)|stomach(1)	5		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TTTGTGCAAGGACTTGGGGAG	0.318			T	"TEC, CHN1, ZNF384"	"extraskeletal myxoid chondrosarcomas, ALL"								16	24					5.03518e-11	6.23768e-11	1	1	0	T	34163181	G	T	34163181	3	4	48	1	0	0	0	0	1	0	0	0	15574	1174	41	2	757	2	TAF15	17	34163181	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	472820	34163181	47032029	3610	8004										
C17orf66	256957	broad.mit.edu	37	chr17	34182689	34182689	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcttcttcacagcctggtgGttttctgcatctagtaagtc	8	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:34182689G>A	ENST00000311880.2	-	14	1492	c.1344C>T	c.(1342-1344)aaC>aaT	p.N448N	C17orf66_ENST00000592980.1_Silent_p.N408N	NM_152781.2	NP_689994.2	A2RTY3	CQ066_HUMAN	chromosome 17 open reading frame 66	448							binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(6)|lung(11)|skin(2)|stomach(4)	38		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CAGCCTGGTGGTTTTCTGCAT	0.527													30	67					0	0	1	0	0	A	34182689	G	A	34182689	2	1	48	1	0	0	0	0	0	0	0	1	1883	1252	44	3		3	C17orf66	17	34182689	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19508	34182689	47012521	3611	8005										
MYO19	80179	broad.mit.edu	37	chr17	34854398	34854398	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagcagcaaggcaggccatTctgatcttaaaaagcaaata	8	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:34854398T>C	ENST00000431794.3	-	25	2991	c.2469A>G	c.(2467-2469)agA>agG	p.R823R	ZNHIT3_ENST00000588253.1_3'UTR|MYO19_ENST00000268852.9_Silent_p.R623R	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	823						mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGCAGGCCATTCTGATCTTAA	0.428													11	16					0	0	1	0	0	C	34854398	T	C	34854398	2	2	48	1	0	0	0	0	0	0	0	1	10114	1780	62	4		4	MYO19	17	34854398	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	671709	34854398	46340812	3612	8006										
MRM1	79922	broad.mit.edu	37	chr17	34958728	34958728	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggaattttggggctgtgctGcgttccgcacacttcctcgg	13	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:34958728G>C	ENST00000250156.7	+	1	728	c.489G>C	c.(487-489)ctG>ctC	p.L163L	MRM1_ENST00000585770.1_Intron	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	163					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GGGCTGTGCTGCGTTCCGCAC	0.622													23	32					0	0	1	0	0	C	34958728	G	C	34958728	2	2	48	1	0	0	0	0	0	0	0	1	9819	1306	46	5		5	MRM1	17	34958728	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	104330	34958728	46236482	3613	8007										
MRM1	79922	broad.mit.edu	37	chr17	34959070	34959070	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgatgacctcaccggatttTtacaggtaatgaggggcaag	12	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:34959070T>G	ENST00000250156.7	+	2	870	c.631T>G	c.(631-633)Tta>Gta	p.L211V	MRM1_ENST00000585770.1_Missense_Mutation_p.L16V	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	211					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CACCGGATTTTTACAGGTAAT	0.582											OREG0024338	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	77					0	0	1	0	0	G	34959070	T	G	34959070	3	3	48	1	0	0	0	0	1	0	0	0	9819	1838	64	4	637	4	MRM1	17	34959070	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	342	34959070	46236140	3614	8008										
GPR179	440435	broad.mit.edu	37	chr17	36482602	36482602	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctttctggaaagaagtgatCcagaggcccatggactaaaa	11	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:36482602C>A	ENST00000342292.4	-	11	6870	c.6850G>T	c.(6850-6852)Gat>Tat	p.D2284Y	GPR179_ENST00000584976.1_Intron	NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	2284						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AAGAAGTGATCCAGAGGCCCA	0.493													62	107					2.66076e-39	3.84021e-39	1	1	0	A	36482602	C	A	36482602	3	1	48	1	0	0	0	0	1	0	0	0	6713	855	30	2	257	2	GPR179	17	36482602	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1523532	36482602	44712608	3615	8009										
PIP4K2B	8396	broad.mit.edu	37	chr17	36933975	36933975	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtttctccaggaagttctTtttactctcctctcccacat	4	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:36933975T>G	ENST00000269554.3	-	7	1252	c.772A>C	c.(772-774)Aag>Cag	p.K258Q	PIP4K2B_ENST00000311500.6_5'UTR	NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	258	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						AGGAAGTTCTTTTTACTCTCC	0.473													35	62					0	0	1	0	0	G	36933975	T	G	36933975	3	3	48	1	0	0	0	0	1	0	0	0	11984	1850	64	4	494	4	PIP4K2B	17	36933975	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	451373	36933975	44261235	3616	8010										
MED1	5469	broad.mit.edu	37	chr17	37564014	37564014	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctgtattctggaagtggtCggataccatcgtctgagctg	13	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:37564014C>T	ENST00000300651.6	-	17	4683	c.4460G>A	c.(4459-4461)cGa>cAa	p.R1487Q	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	1487					androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGGAAGTGGTCGGATACCATC	0.458										HNSCC(31;0.082)			15	24					0	0	1	0	0	T	37564014	C	T	37564014	3	4	48	1	0	0	0	0	1	0	0	0	9474	884	31	1	289	1	MED1	17	37564014	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	630039	37564014	43631196	3617	8011										
STARD3	0	broad.mit.edu	37	chr17	37814703	37814703	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctgctccccatcgtctctTttgtcctcgcctggttggag	9	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:37814703T>G	ENST00000336308.5	+	6	693	c.475T>G	c.(475-477)Ttt>Gtt	p.F159V	STARD3_ENST00000580611.1_Missense_Mutation_p.F133V|STARD3_ENST00000544210.2_Silent_p.L154L|STARD3_ENST00000578232.1_3'UTR|STARD3_ENST00000394250.4_Missense_Mutation_p.F141V	NM_001165937.1|NM_006804.3	NP_001159409.1|NP_006795.3	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain containing 3	159	MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CATCGTCTCTTTTGTCCTCGC	0.602													21	34					0	0	1	0	0	G	37814703	T	G	37814703	3	3	48	1	0	0	0	0	1	0	0	0	15312	1841	64	4	493	4	STARD3	17	37814703	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	250689	37814703	43380507	3618	8012										
WIPF2	147179	broad.mit.edu	37	chr17	38421170	38421170	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggaccaagtggccagtctCtggctcctcctcctccgcct	9	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:38421170C>T	ENST00000323571.4	+	5	982	c.742C>T	c.(742-744)Ctg>Ttg	p.L248L	WIPF2_ENST00000494757.1_3'UTR|WIPF2_ENST00000585043.1_Silent_p.L248L|WIPF2_ENST00000394103.3_Intron|WIPF2_ENST00000536600.1_Intron|WIPF2_ENST00000583130.1_Silent_p.L248L	NM_133264.4	NP_573571.1	Q8TF74	WIPF2_HUMAN	WAS/WASL interacting protein family, member 2	248						cytoplasm|cytoskeleton	actin binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	30						TGGCCAGTCTCTGGCTCCTCC	0.602										HNSCC(43;0.11)			14	224					0	0	1	0	0	T	38421170	C	T	38421170	2	4	48	1	0	0	0	0	0	0	0	1	17427	912	32	3		3	WIPF2	17	38421170	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	606467	38421170	42774040	3619	8013										
CDC6	990	broad.mit.edu	37	chr17	38458221	38458221	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctgaaagataaagctttaAttggaaatatcttagctact	6	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:38458221A>C	ENST00000209728.4	+	12	2122	c.1651A>C	c.(1651-1653)Att>Ctt	p.I551L		NM_001254.3	NP_001245.1	Q99741	CDC6_HUMAN	cell division cycle 6	551					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	21						TAAAGCTTTAATTGGAAATAT	0.368													20	47					0	0	1	0	0	C	38458221	A	C	38458221	3	2	48	1	0	0	0	0	1	0	0	0	3105	101	4	4	1693	4	CDC6	17	38458221	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	37051	38458221	42736989	3620	8014										
KRT24	192666	broad.mit.edu	37	chr17	38859658	38859658	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacccctgccaaatccagaGaccccgccaaagctagaacc	7	17	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:38859658G>T	ENST00000264651.2	-	1	344	c.288C>A	c.(286-288)gtC>gtA	p.V96V		NM_019016.2	NP_061889.2	Q2M2I5	K1C24_HUMAN	keratin 24	96	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00526)				CAAATCCAGAGACCCCGCCAA	0.567													85	160					1.07134e-49	1.55542e-49	1	1	0	T	38859658	G	T	38859658	2	4	48	1	0	0	0	0	0	0	0	1	8503	929	33	2		2	KRT24	17	38859658	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	401437	38859658	42335552	3621	8015										
KRTAP1-1	81851	broad.mit.edu	37	chr17	39197617	39197617	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccactggtggagcagctgggAaatccacagaagctggtctg	14	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:39197617A>C	ENST00000306271.4	-	1	96	c.33T>G	c.(31-33)ttT>ttG	p.F11L		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	11						extracellular region|keratin filament				NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCAGCTGGGAAATCCACAGA	0.582													24	61					0	0	1	0	0	C	39197617	A	C	39197617	3	2	48	1	0	0	0	0	1	0	0	0	8544	243	9	4	504	4	KRTAP1-1	17	39197617	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	337959	39197617	41997593	3622	8016										
KRTAP9-4	85280	broad.mit.edu	37	chr17	39406152	39406152	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaacttgctgtcaaaacacCtgctgccagcccacctgtgt	7	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:39406152C>T	ENST00000334109.2	+	1	214	c.180C>T	c.(178-180)acC>acT	p.T60T		NM_033191.2	NP_149461.2	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	60	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament				breast(1)|large_intestine(1)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GTCAAAACACCTGCTGCCAGC	0.642													52	106					0	0	1	0	0	T	39406152	C	T	39406152	2	4	48	1	0	0	0	0	0	0	0	1	8613	668	24	3		3	KRTAP9-4	17	39406152	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	208535	39406152	41789058	3623	8017										
KRT33B	3884	broad.mit.edu	37	chr17	39521451	39521451	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtgctgggcctgcagctcGatctccagggcattgactgt	13	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:39521451G>A	ENST00000251646.3	-	5	901	c.852C>T	c.(850-852)atC>atT	p.I284I		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	284	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				CCTGCAGCTCGATCTCCAGGG	0.597													53	103					0	0	1	0	0	A	39521451	G	A	39521451	2	1	48	1	0	0	0	0	0	0	0	1	8512	1048	37	1		1	KRT33B	17	39521451	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	115299	39521451	41673759	3624	8018										
KRT19	3880	broad.mit.edu	37	chr17	39681143	39681143	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctcttccttcaggccttcGatctgcatctccaggtcggt	9	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:39681143G>A	ENST00000361566.3	-	3	672	c.612C>T	c.(610-612)atC>atT	p.I204I		NM_002276.4	NP_002267.2			keratin 19									p.L195fs*3(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				TCAGGCCTTCGATCTGCATCT	0.607													60	93					0	0	1	0	0	A	39681143	G	A	39681143	2	1	48	1	0	0	0	0	0	0	0	1	8498	1048	37	1		1	KRT19	17	39681143	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	159692	39681143	41514067	3625	8019										
KRT9	3857	broad.mit.edu	37	chr17	39725739	39725739	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatgagctgctcatactccTgacgcatgtcattgagggtc	10	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:39725739T>C	ENST00000246662.4	-	4	1048	c.983A>G	c.(982-984)cAg>cGg	p.Q328R	KRT9_ENST00000588431.1_Missense_Mutation_p.Q95R	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	328	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				CTCATACTCCTGACGCATGTC	0.502													5	47					0	0	1	0	0	C	39725739	T	C	39725739	3	2	48	1	0	0	0	0	1	0	0	0	8543	1580	55	4	904	4	KRT9	17	39725739	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	44596	39725739	41469471	3626	8020										
FKBP10	60681	broad.mit.edu	37	chr17	39978543	39978543	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcctgggcaggaccctgaGaaaaccataggagacatgtt	12	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:39978543G>T	ENST00000321562.4	+	10	1736	c.1632G>T	c.(1630-1632)gaG>gaT	p.E544D	FKBP10_ENST00000544340.1_Missense_Mutation_p.E317D	NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	544	EF-hand 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		AGGACCCTGAGAAAACCATAG	0.602													7	21					0.0293803	0.0299069	1	1	0	T	39978543	G	T	39978543	3	4	48	1	0	0	0	0	1	0	0	0	5934	933	33	2	1670	2	FKBP10	17	39978543	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	252804	39978543	41216667	3627	8021										
KLHL10	317719	broad.mit.edu	37	chr17	40001831	40001831	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actccagacgttgctatgtcAgtgtgacagtcctcggcaat	10	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:40001831A>G	ENST00000293303.4	+	3	1291	c.1138A>G	c.(1138-1140)Agt>Ggt	p.S380G		NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	380						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				TTGCTATGTCAGTGTGACAGT	0.453													6	81					0	0	1	0	0	G	40001831	A	G	40001831	3	3	48	1	0	0	0	0	1	0	0	0	8408	188	7	4	1148	4	KLHL10	17	40001831	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	23288	40001831	41193379	3628	8022										
ACLY	47	broad.mit.edu	37	chr17	40063734	40063734	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgaaggggggagggaactcGatgtcaccccacttcacttt	12	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:40063734G>A	ENST00000352035.2	-	7	838	c.708C>T	c.(706-708)atC>atT	p.I236I	ACLY_ENST00000537919.1_Intron|ACLY_ENST00000353196.1_Silent_p.I236I|ACLY_ENST00000393896.2_Silent_p.I236I|ACLY_ENST00000590151.1_Silent_p.I236I	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	236					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				GAGGGAACTCGATGTCACCCC	0.587													35	69					0	0	1	0	0	A	40063734	G	A	40063734	2	1	48	1	0	0	0	0	0	0	0	1	143	1048	37	1		1	ACLY	17	40063734	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	61903	40063734	41131476	3629	8023										
WNK4	65266	broad.mit.edu	37	chr17	40947053	40947053	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcctccagcacacccgagTttccggtcccactctctcag	6	19	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:40947053T>C	ENST00000246914.5	+	14	2635	c.2614T>C	c.(2614-2616)Ttt>Ctt	p.F872L		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	872					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CACACCCGAGTTTCCGGTCCC	0.567													55	82					0	0	1	0	0	C	40947053	T	C	40947053	3	2	48	1	0	0	0	0	1	0	0	0	17439	1725	60	4	2668	4	WNK4	17	40947053	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	883319	40947053	40248157	3630	8024										
CNTD1	124817	broad.mit.edu	37	chr17	40956314	40956314	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagataataagagagagtCtcagaattggagggctctga	13	4	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:40956314C>A	ENST00000588408.1	+	3	593	c.317C>A	c.(316-318)tCt>tAt	p.S106Y	CNTD1_ENST00000588527.1_Missense_Mutation_p.S23Y	NM_173478.2	NP_775749.2	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	106	Cyclin N-terminal.									central_nervous_system(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AAGAGAGAGTCTCAGAATTGG	0.458													28	69					1.16021e-09	1.40238e-09	1	1	0	A	40956314	C	A	40956314	3	1	48	1	0	0	0	0	1	0	0	0	3658	913	32	2	327	2	CNTD1	17	40956314	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9261	40956314	40238896	3631	8025										
G6PC3	92579	broad.mit.edu	37	chr17	42152412	42152412	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttgtcgcgaatcttcatCttagcacatttccctcacca	6	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42152412C>A	ENST00000269097.4	+	4	723	c.492C>A	c.(490-492)atC>atA	p.I164I		NM_138387.3	NP_612396.1	Q9BUM1	G6PC3_HUMAN	glucose 6 phosphatase, catalytic, 3	164					gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	11		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GAATCTTCATCTTAGCACATT	0.552													49	118					6.03219e-31	8.6264e-31	1	1	0	A	42152412	C	A	42152412	2	1	48	1	0	0	0	0	0	0	0	1	6179	903	32	2		2	G6PC3	17	42152412	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1196098	42152412	39042798	3632	8026										
C17orf53	78995	broad.mit.edu	37	chr17	42225299	42225299	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgaatgctgggcgcctgaGacctgtctcttctaggccac	12	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42225299G>T	ENST00000319977.4	+	3	365	c.128G>T	c.(127-129)aGa>aTa	p.R43I	C17orf53_ENST00000585683.1_Missense_Mutation_p.R43I|C17orf53_ENST00000245382.6_Missense_Mutation_p.R43I	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	43										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGGCGCCTGAGACCTGTCTCT	0.572													6	86					0.00116845	0.00122532	1	1	0	T	42225299	G	T	42225299	3	4	48	1	0	0	0	0	1	0	0	0	1871	942	33	2	138	2	C17orf53	17	42225299	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	72887	42225299	38969911	3633	8027										
ASB16	92591	broad.mit.edu	37	chr17	42255579	42255579	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactcctggcctaggagcacGaagccttctacagctcggcc	10	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42255579G>A	ENST00000293414.1	+	5	1267	c.1183G>A	c.(1183-1185)Gaa>Aaa	p.E395K	ASB16-AS1_ENST00000592897.1_RNA|ASB16-AS1_ENST00000585457.1_RNA|ASB16-AS1_ENST00000591166.1_RNA|ASB16-AS1_ENST00000588785.1_RNA	NM_080863.4	NP_543139.4	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box containing 16	395					intracellular signal transduction		protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|liver(2)|lung(2)|prostate(1)	14		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTAGGAGCACGAAGCCTTCTA	0.637													7	26					0	0	1	0	0	A	42255579	G	A	42255579	3	1	48	1	0	0	0	0	1	0	0	0	1019	1059	37	1	1201	1	ASB16	17	42255579	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30280	42255579	38939631	3634	8028										
TMUB2	79089	broad.mit.edu	37	chr17	42268132	42268132	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtgtggtctggtacttccGaatcaattaccgccaattct	10	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42268132G>A	ENST00000319511.6	+	3	1456	c.806G>A	c.(805-807)cGa>cAa	p.R269Q	TMUB2_ENST00000592825.1_3'UTR|TMUB2_ENST00000538716.2_Missense_Mutation_p.R289Q|TMUB2_ENST00000587989.1_Missense_Mutation_p.R289Q|TMUB2_ENST00000446571.3_Missense_Mutation_p.R232Q|TMUB2_ENST00000590235.1_3'UTR|TMUB2_ENST00000589785.1_Missense_Mutation_p.R269Q|TMUB2_ENST00000589184.1_3'UTR|TMUB2_ENST00000357984.3_Missense_Mutation_p.R269Q|TMUB2_ENST00000587172.1_3'UTR	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	289						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGGTACTTCCGAATCAATTAC	0.547													37	85					0	0	1	0	0	A	42268132	G	A	42268132	3	1	48	1	0	0	0	0	1	0	0	0	16324	1058	37	1	876	1	TMUB2	17	42268132	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	12553	42268132	38927078	3635	8029										
RUNDC3A	10900	broad.mit.edu	37	chr17	42392102	42392102	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggccctctgcctccccacaGacggttctatgactctggag	10	15	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42392102G>T	ENST00000426726.3	+	5	732		c.e5-1		AC003102.3_ENST00000588097.1_RNA|RUNDC3A_ENST00000225441.7_Splice_Site|RUNDC3A_ENST00000590941.1_Splice_Site	NM_001144825.1	NP_001138297.1	Q59EK9	RUN3A_HUMAN	RUN domain containing 3A						small GTPase mediated signal transduction		small GTPase regulator activity			large_intestine(1)|lung(1)|ovary(2)	4		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCTCCCCACAGACGGTTCTAT	0.632													16	21					1.99824e-07	2.29918e-07	1	1	0	T	42392102	G	T	42392102	5	4	48	1	0	0	0	0	0	0	1	0	13795	956	33	2	476	2	RUNDC3A	17	42392102	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	123970	42392102	38803108	3636	8030										
ITGA2B	3674	broad.mit.edu	37	chr17	42466810	42466810	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacccactccagaagccagAgggcttgcagtggacacaaa	11	13	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42466810A>G	ENST00000262407.5	-	1	63	c.32T>C	c.(31-33)cTc>cCc	p.L11P	ITGA2B_ENST00000353281.4_Missense_Mutation_p.L11P	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CAGAAGCCAGAGGGCTTGCAG	0.602													22	47					0	0	1	0	0	G	42466810	A	G	42466810	3	3	48	1	0	0	0	0	1	0	0	0	7919	304	11	4	3207	4	ITGA2B	17	42466810	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	74708	42466810	38728400	3637	8031										
C17orf104	284071	broad.mit.edu	37	chr17	42745125	42745125	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagccaagccccagagtggaCattatgatcctgaggaaggt	12	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42745125C>T	ENST00000409122.2	+	5	1988	c.1846C>T	c.(1846-1848)Cat>Tat	p.H616Y	C17orf104_ENST00000409464.1_Missense_Mutation_p.H450Y|C17orf104_ENST00000359945.3_Missense_Mutation_p.H616Y	NM_001145080.2	NP_001138552.2	A2RUB1	CQ104_HUMAN	chromosome 17 open reading frame 104	616										autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|skin(1)	24						CCAGAGTGGACATTATGATCC	0.383													3	21					0	0	1	0	0	T	42745125	C	T	42745125	3	4	48	1	0	0	0	0	1	0	0	0	1858	478	17	3	1864	3	C17orf104	17	42745125	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	278315	42745125	38450085	3638	8032										
GJC1	10052	broad.mit.edu	37	chr17	42882757	42882757	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatcactttctaactccatCtctggatacatcataggatc	4	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:42882757C>A	ENST00000426548.1	-	3	698	c.429G>T	c.(427-429)gaG>gaT	p.E143D	GJC1_ENST00000592524.1_Missense_Mutation_p.E143D|GJC1_ENST00000590758.1_Missense_Mutation_p.E143D|GJC1_ENST00000330514.4_Missense_Mutation_p.E143D	NM_001080383.1|NM_005497.3	NP_001073852.1|NP_005488.2	P36383	CXG1_HUMAN	gap junction protein, gamma 1, 45kDa	143					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				CTAACTCCATCTCTGGATACA	0.498													10	137					0.000442599	0.00046913	1	1	0	A	42882757	C	A	42882757	3	1	48	1	0	0	0	0	1	0	0	0	6455	912	32	2	765	2	GJC1	17	42882757	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	137632	42882757	38312453	3639	8033										
CRHR1	1394	broad.mit.edu	37	chr17	43906647	43906647	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggccactgtatctccctgGtggccctcctggtggccttt	12	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:43906647G>A	ENST00000314537.5	+	5	619	c.394G>A	c.(394-396)Gtg>Atg	p.V132M	CRHR1_ENST00000339069.5_Missense_Mutation_p.V31M|CRHR1_ENST00000577353.1_Missense_Mutation_p.V132M|CRHR1_ENST00000398285.3_Missense_Mutation_p.V132M|CRHR1_ENST00000293493.7_5'UTR|CRHR1_ENST00000352855.5_Missense_Mutation_p.V92M	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	132					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding	p.V132L(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		TATCTCCCTGGTGGCCCTCCT	0.587													5	29					0	0	1	0	0	A	43906647	G	A	43906647	3	1	48	1	0	0	0	0	1	0	0	0	3894	1261	44	3	412	3	CRHR1	17	43906647	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1023890	43906647	37288563	3640	8034										
CDC27	996	broad.mit.edu	37	chr17	45216210	45216210	+	Silent	SNP	A	A	C													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtagatctccatgccttcAactctataattctcaatcct					rs62075659		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:45216210A>C	ENST00000066544.3	-	13	1692	c.1599T>G	c.(1597-1599)gtT>gtG	p.V533V	CDC27_ENST00000531206.1_Silent_p.V539V|CDC27_ENST00000527547.1_Silent_p.V532V|CDC27_ENST00000446365.2_Silent_p.V472V	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	533					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.V533V(1)|p.V539V(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CCATGCCTTCAACTCTATAAT	0.318													3	32					0	0	1	0	0	C	45216210	A	C	45216210	2	2	48	1	0	0	0	0	0	0	0	1	3088	117	5	4		4	CDC27	17	45216210	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1309563	45216210	35979000	3641	8035	25	2								
CDC27	996	broad.mit.edu	37	chr17	45216218	45216218	+	Missense_Mutation	SNP	A	A	G													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctccatgccttcaactctatAattctcaatccttctaacct							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:45216218A>G	ENST00000066544.3	-	13	1684	c.1591T>C	c.(1591-1593)Tat>Cat	p.Y531H	CDC27_ENST00000531206.1_Missense_Mutation_p.Y537H|CDC27_ENST00000527547.1_Missense_Mutation_p.Y530H|CDC27_ENST00000446365.2_Missense_Mutation_p.Y470H	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	531					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TCAACTCTATAATTCTCAATC	0.328													3	28					0	0	1	0	0	G	45216218	A	G	45216218	3	3	48	1	0	0	0	0	1	0	0	0	3088	362	13	4	911	4	CDC27	17	45216218	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	8	45216218	35978992	3642	8036	25	2								
CDC27	996	broad.mit.edu	37	chr17	45249313	45249313	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacacaacattttgcaagcAggtatttgcattgcggtgta	9	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:45249313A>G	ENST00000066544.3	-	3	314	c.221T>C	c.(220-222)cTg>cCg	p.L74P	CDC27_ENST00000528748.1_5'UTR|CDC27_ENST00000531206.1_Missense_Mutation_p.L74P|CDC27_ENST00000527547.1_Missense_Mutation_p.L74P|CDC27_ENST00000446365.2_Intron	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	74					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TTTTGCAAGCAGGTATTTGCA	0.338													4	29					0	0	1	0	0	G	45249313	A	G	45249313	3	3	48	1	0	0	0	0	1	0	0	0	3088	188	7	4	2339	4	CDC27	17	45249313	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	33095	45249313	35945897	3643	8037										
CDC27	996	broad.mit.edu	37	chr17	45258949	45258949	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgcataaaggcgttctgCgaggaaaaccgcatctcggt	11	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:45258949C>T	ENST00000066544.3	-	2	175	c.82G>A	c.(82-84)Gca>Aca	p.A28T	CDC27_ENST00000528748.1_5'UTR|CDC27_ENST00000531206.1_Missense_Mutation_p.A28T|CDC27_ENST00000527547.1_Missense_Mutation_p.A28T|CDC27_ENST00000446365.2_Missense_Mutation_p.R16H	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	28					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.A28T(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						AGGCGTTCTGCGAGGAAAACC	0.348													5	12					0	0	1	0	0	T	45258949	C	T	45258949	3	4	48	1	0	0	0	0	1	0	0	0	3088	768	27	1	2482	1	CDC27	17	45258949	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	9636	45258949	35936261	3644	8038										
PNPO	55163	broad.mit.edu	37	chr17	46022057	46022057	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccgcttcttcactaacttCgagagtcgaaaaggaaaaga	8	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:46022057C>T	ENST00000225573.4	+	3	444	c.339C>T	c.(337-339)ttC>ttT	p.F113F	PNPO_ENST00000544840.1_Silent_p.F113F|PNPO_ENST00000434554.2_Silent_p.F113F|PNPO_ENST00000534893.1_Silent_p.F18F	NM_018129.3	NP_060599.1	Q9NVS9	PNPO_HUMAN	pyridoxamine 5'-phosphate oxidase	113					pyridoxine biosynthetic process	cytosol	FMN binding|pyridoxamine-phosphate oxidase activity			endometrium(2)|large_intestine(1)|lung(1)|urinary_tract(1)	5					Pyridoxal Phosphate(DB00114)	TCACTAACTTCGAGAGTCGAA	0.507													50	92					0	0	1	0	0	T	46022057	C	T	46022057	2	4	48	1	0	0	0	0	0	0	0	1	12219	883	31	1		1	PNPO	17	46022057	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	763108	46022057	35173153	3645	8039										
CALCOCO2	10241	broad.mit.edu	37	chr17	46933497	46933497	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagactgagtgagaacgaaaTtatatgtaatgctctgcaga	10	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:46933497T>G	ENST00000258947.3	+	10	1057	c.956T>G	c.(955-957)aTt>aGt	p.I319S	CALCOCO2_ENST00000509507.1_Missense_Mutation_p.I340S|CALCOCO2_ENST00000508679.1_Missense_Mutation_p.I247S|CALCOCO2_ENST00000448105.2_Missense_Mutation_p.I343S|CALCOCO2_ENST00000416445.2_Missense_Mutation_p.I277S	NM_001261390.1|NM_001261391.1|NM_001261393.1|NM_001261395.1|NM_005831.4	NP_001248319.1|NP_001248320.1|NP_001248322.1|NP_001248324.1|NP_005822.1	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	319					response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	15						GAGAACGAAATTATATGTAAT	0.378													18	33					0	0	1	0	0	G	46933497	T	G	46933497	3	3	48	1	0	0	0	0	1	0	0	0	2596	1493	52	4	990	4	CALCOCO2	17	46933497	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	911440	46933497	34261713	3646	8040										
IGF2BP1	10642	broad.mit.edu	37	chr17	47075230	47075230	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcaaatccggctacgccttCgtggactgcccggacgagca	12	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:47075230C>A	ENST00000290341.3	+	1	457	c.123C>A	c.(121-123)ttC>ttA	p.F41L	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.F41L|IGF2BP1_ENST00000515586.1_3'UTR	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	41	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GCTACGCCTTCGTGGACTGCC	0.587													17	133					5.03518e-11	6.23768e-11	1	1	0	A	47075230	C	A	47075230	3	1	48	1	0	0	0	0	1	0	0	0	7616	883	31	2	125	2	IGF2BP1	17	47075230	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	141733	47075230	34119980	3647	8041										
ZNF652	22834	broad.mit.edu	37	chr17	47394794	47394794	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctctgtgtcatcagaattCtcccggtcttccttaacagc	6	14	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:47394794C>A	ENST00000362063.2	-	2	612	c.294G>T	c.(292-294)gaG>gaT	p.E98D	ZNF652_ENST00000430262.2_Missense_Mutation_p.E98D	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	98	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CATCAGAATTCTCCCGGTCTT	0.428													41	63					9.85913e-13	1.24945e-12	1	1	0	A	47394794	C	A	47394794	3	1	48	1	0	0	0	0	1	0	0	0	18121	912	32	2	1546	2	ZNF652	17	47394794	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	319564	47394794	33800416	3648	8042										
DLX3	1747	broad.mit.edu	37	chr17	48068973	48068973	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgctgtaagtggggtccacTcaggttctgtgcgtgatacc	13	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:48068973T>C	ENST00000434704.2	-	3	997	c.772A>G	c.(772-774)Agt>Ggt	p.S258G	DLX3_ENST00000512495.2_Missense_Mutation_p.S138G	NM_005220.2	NP_005211.1	O60479	DLX3_HUMAN	distal-less homeobox 3	258						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						TGGGGTCCACTCAGGTTCTGT	0.682													17	25					0	0	1	0	0	C	48068973	T	C	48068973	3	2	48	1	0	0	0	0	1	0	0	0	4600	1551	54	4	95	4	DLX3	17	48068973	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	674179	48068973	33126237	3649	8043										
MYCBPAP	84073	broad.mit.edu	37	chr17	48606124	48606124	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgggaaggaggagcggaaaGgagcagcccaggaaaagaag	18	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:48606124G>T	ENST00000323776.5	+	17	2767	c.2605G>T	c.(2605-2607)Gga>Tga	p.G869*	MYCBPAP_ENST00000436259.2_Nonsense_Mutation_p.G832*	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	832					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GGAGCGGAAAGGAGCAGCCCA	0.527													15	25					1.15088e-07	1.32965e-07	1	1	0	T	48606124	G	T	48606124	4	4	48	1	0	0	0	0	0	1	0	0	10066	1001	35	5	2671	5	MYCBPAP	17	48606124	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	537151	48606124	32589086	3650	8044										
SPATA20	64847	broad.mit.edu	37	chr17	48625670	48625670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctcccgggacaaggaccGaagtgcgacggtcagtagtt	13	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:48625670G>A	ENST00000006658.6	+	3	272	c.152G>A	c.(151-153)cGa>cAa	p.R51Q	SPATA20_ENST00000393244.3_5'UTR|SPATA20_ENST00000356488.4_Missense_Mutation_p.R35Q|SPATA20_ENST00000511937.1_3'UTR	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	35					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			GACAAGGACCGAAGTGCGACG	0.647													15	23					0	0	1	0	0	A	48625670	G	A	48625670	3	1	48	1	0	0	0	0	1	0	0	0	15061	1058	37	1	162	1	SPATA20	17	48625670	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19546	48625670	32569540	3651	8045										
CA10	56934	broad.mit.edu	37	chr17	49731017	49731017	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttacttttataaatatagaAactaccaccaatccatttgg	3	9	0	1	rs145659285		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:49731017A>C	ENST00000451037.2	-	5	1486	c.546T>G	c.(544-546)gtT>gtG	p.V182V	CA10_ENST00000285273.4_Silent_p.V182V|CA10_ENST00000442502.2_Silent_p.V182V|CA10_ENST00000340813.6_Silent_p.V188V|CA10_ENST00000570565.1_Silent_p.V107V|CA10_ENST00000571918.1_5'UTR	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	182					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TAAATATAGAAACTACCACCA	0.403													11	13					0	0	1	0	0	C	49731017	A	C	49731017	2	2	48	1	0	0	0	0	0	0	0	1	2529	1	1	4		4	CA10	17	49731017	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1105347	49731017	31464193	3652	8046										
TRIM25	7706	broad.mit.edu	37	chr17	54978869	54978869	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggtggatgccttttatcAgcttgtggttcagttccacc	10	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:54978869A>G	ENST00000316881.4	-	4	1047	c.998T>C	c.(997-999)cTg>cCg	p.L333P	TRIM25_ENST00000537230.1_Missense_Mutation_p.L333P	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	333	Interaction with influenza A virus NS1.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					GCCTTTTATCAGCTTGTGGTT	0.542													89	232					0	0	1	0	0	G	54978869	A	G	54978869	3	3	48	1	0	0	0	0	1	0	0	0	16559	188	7	4	918	4	TRIM25	17	54978869	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	5247852	54978869	26216341	3653	8047										
MSI2	0	broad.mit.edu	37	chr17	55478757	55478757	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagatggtcacaagaacaaaGaaaatatttgtaggcgggtt	11	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:55478757G>T	ENST00000284073.2	+	6	539	c.330G>T	c.(328-330)aaG>aaT	p.K110N	MSI2_ENST00000416426.2_Missense_Mutation_p.K88N|MSI2_ENST00000579180.1_Missense_Mutation_p.K6N|MSI2_ENST00000322684.3_Missense_Mutation_p.K106N|MSI2_ENST00000442934.2_Missense_Mutation_p.K49N	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	110	RRM 1.|RRM 2.					cytoplasm	nucleotide binding|RNA binding	p.K106K(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		CAAGAACAAAGAAAATATTTG	0.448			T	HOXA9	CML								29	49					9.80776e-20	1.33792e-19	1	1	0	T	55478757	G	T	55478757	3	4	48	1	0	0	0	0	1	0	0	0	9924	933	33	2	402	2	MSI2	17	55478757	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	499888	55478757	25716453	3654	8048										
SEPT4	5414	broad.mit.edu	37	chr17	56598957	56598957	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatcctcatcagagtcacaGtctgggaattgatagatctt	8	9	6	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:56598957G>T	ENST00000457347.2	-	9	1155	c.1011C>A	c.(1009-1011)gaC>gaA	p.D337E	SEPT4_ENST00000583114.1_Missense_Mutation_p.D175E|RP11-112H10.4_ENST00000580589.1_RNA|SEPT4_ENST00000580809.1_3'UTR|SEPT4_ENST00000579371.1_Missense_Mutation_p.D223E|SEPT4_ENST00000580844.1_Missense_Mutation_p.D223E|SEPT4_ENST00000426861.1_3'UTR|SEPT4_ENST00000412945.3_Missense_Mutation_p.D314E|SEPT4_ENST00000393086.1_Missense_Mutation_p.D303E|SEPT4_ENST00000317256.6_Missense_Mutation_p.D303E|SEPT4_ENST00000317268.3_Missense_Mutation_p.D322E	NM_001256782.1	NP_001243711.1	O43236	SEPT4_HUMAN	septin 4	322					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	18	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGAGTCACAGTCTGGGAATT	0.493													21	48					5.26018e-13	6.70247e-13	1	1	0	T	56598957	G	T	56598957	3	4	48	1	0	0	0	0	1	0	0	0	14119	1020	36	5	490	5	SEPT4	17	56598957	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1120200	56598957	24596253	3655	8049										
SEPT4	5414	broad.mit.edu	37	chr17	56604289	56604289	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttcctgagaaatccttcacGaacttgctcagttctccatc	5	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:56604289G>A	ENST00000426861.1	-	2	140	c.54C>T	c.(52-54)ttC>ttT	p.F18F	SEPT4_ENST00000583114.1_5'UTR|RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA|SEPT4_ENST00000580791.1_5'UTR|SEPT4_ENST00000580809.1_Intron|SEPT4_ENST00000579371.1_Intron|SEPT4_ENST00000580844.1_Intron|SEPT4_ENST00000457347.2_Silent_p.F52F|SEPT4_ENST00000412945.3_Silent_p.F29F|SEPT4_ENST00000393086.1_Silent_p.F18F|SEPT4_ENST00000317256.6_Silent_p.F18F|SEPT4_ENST00000317268.3_Silent_p.F37F	NM_080415.2	NP_536340.1	O43236	SEPT4_HUMAN	septin 4	37					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity	p.F37F(1)		NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	18	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AATCCTTCACGAACTTGCTCA	0.617													41	68					0	0	1	0	0	A	56604289	G	A	56604289	2	1	48	1	0	0	0	0	0	0	0	1	14119	1049	37	1		1	SEPT4	17	56604289	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5332	56604289	24590921	3656	8050										
C17orf47	284083	broad.mit.edu	37	chr17	56620179	56620179	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaaaaccggacaataaaaGatctagggaaggagagcact	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:56620179G>T	ENST00000321691.3	-	1	1550	c.1369C>A	c.(1369-1371)Ctt>Att	p.L457I	RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	457										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GACAATAAAAGATCTAGGGAA	0.478													85	157					3.73172e-31	5.33794e-31	1	1	0	T	56620179	G	T	56620179	3	4	48	1	0	0	0	0	1	0	0	0	1867	942	33	2	351	2	C17orf47	17	56620179	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	15890	56620179	24575031	3657	8051										
TEX14	56155	broad.mit.edu	37	chr17	56682459	56682459	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcgtaggaaggggcactcGagtcaggtccctctgtacac	13	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:56682459G>A	ENST00000389934.3	-	11	1333	c.1216C>T	c.(1216-1218)Cga>Tga	p.R406*	TEX14_ENST00000240361.8_Nonsense_Mutation_p.R412*|TEX14_ENST00000349033.5_Nonsense_Mutation_p.R406*	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	412	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGGGCACTCGAGTCAGGTCC	0.478													21	38					0	0	1	0	0	A	56682459	G	A	56682459	4	1	48	1	0	0	0	0	0	1	0	0	15836	1066	37	1	3351	1	TEX14	17	56682459	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	62280	56682459	24512751	3658	8052										
TRIM37	4591	broad.mit.edu	37	chr17	57106003	57106003	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggccatttgagttttgagtCtttttagcatctttaaatca	7	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:57106003C>A	ENST00000376149.3	-	19	2473	c.1664G>T	c.(1663-1665)aGa>aTa	p.R555I	TRIM37_ENST00000393065.2_Missense_Mutation_p.R643I|TRIM37_ENST00000393066.3_Missense_Mutation_p.R677I|TRIM37_ENST00000262294.7_Missense_Mutation_p.R677I			O94972	TRI37_HUMAN	tripartite motif containing 37	677						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AGTTTTGAGTCTTTTTAGCAT	0.393									Mulibrey Nanism				22	33					3.62473e-10	4.42315e-10	1	1	0	A	57106003	C	A	57106003	3	1	48	1	0	0	0	0	1	0	0	0	16571	913	32	2	896	2	TRIM37	17	57106003	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	423544	57106003	24089207	3659	8053										
SKA2	348235	broad.mit.edu	37	chr17	57196697	57196697	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacctccaggtctgtttgctTctgtagtttttgtatcatat	7	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:57196697T>C	ENST00000330137.7	-	3	385	c.280A>G	c.(280-282)Aag>Gag	p.K94E	SKA2_ENST00000578105.1_Missense_Mutation_p.K65E|SKA2_ENST00000580541.1_Intron|SKA2_ENST00000437036.2_Intron|SKA2_ENST00000583927.1_Intron|SKA2_ENST00000581068.1_Intron|SKA2_ENST00000583380.1_Missense_Mutation_p.K94E	NM_182620.3	NP_872426.1	Q8WVK7	SKA2_HUMAN	spindle and kinetochore associated complex subunit 2	94					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding			lung(4)	4						TCTGTTTGCTTCTGTAGTTTT	0.378													15	32					0	0	1	0	0	C	57196697	T	C	57196697	3	2	48	1	0	0	0	0	1	0	0	0	14407	1792	62	4	93	4	SKA2	17	57196697	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	90694	57196697	23998513	3660	8054										
CLTC	1213	broad.mit.edu	37	chr17	57724861	57724861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaatggatctctttgaataCggttgctcttgttacggata	10	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:57724861C>T	ENST00000269122.3	+	3	627	c.353C>T	c.(352-354)aCg>aTg	p.T118M	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Missense_Mutation_p.T118M	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	118	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TCTTTGAATACGGTTGCTCTT	0.403			T	"ALK, TFE3"	"ALCL, renal "								10	74					0	0	1	0	0	T	57724861	C	T	57724861	3	4	48	1	0	0	0	0	1	0	0	0	3589	536	19	1	363	1	CLTC	17	57724861	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	528164	57724861	23470349	3661	8055										
TUBD1	51174	broad.mit.edu	37	chr17	57958404	57958404	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaccactgaaagagtcacAtttctccacttccttccgga	5	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:57958404A>C	ENST00000325752.3	-	4	665	c.388T>G	c.(388-390)Tgt>Ggt	p.C130G	TUBD1_ENST00000394239.3_Missense_Mutation_p.C130G|TUBD1_ENST00000376094.4_Missense_Mutation_p.C130G|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000340993.6_Missense_Mutation_p.C130G|TUBD1_ENST00000539018.1_Intron|TUBD1_ENST00000592426.1_Missense_Mutation_p.C130G|TUBD1_ENST00000591611.1_Intron	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	130					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			AAAGAGTCACATTTCTCCACT	0.403													53	85					0	0	1	0	0	C	57958404	A	C	57958404	3	2	48	1	0	0	0	0	1	0	0	0	16823	217	8	4	997	4	TUBD1	17	57958404	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	233543	57958404	23236806	3662	8056										
HEATR6	63897	broad.mit.edu	37	chr17	58136792	58136792	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccactacaaacctttgtggcGaatataaggctttatctggt	8	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:58136792G>A	ENST00000184956.6	-	11	1730	c.1714C>T	c.(1714-1716)Cgc>Tgc	p.R572C	HEATR6_ENST00000585976.1_Missense_Mutation_p.R572C	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	572							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CCTTTGTGGCGAATATAAGGC	0.348													20	46					0	0	1	0	0	A	58136792	G	A	58136792	3	1	48	1	0	0	0	0	1	0	0	0	7073	1058	37	1	1871	1	HEATR6	17	58136792	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	178388	58136792	23058418	3663	8057										
HEATR6	63897	broad.mit.edu	37	chr17	58137338	58137338	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactctctaatgctgcaagcGatcattacggagaagggggt	12	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:58137338G>A	ENST00000184956.6	-	10	1552	c.1536C>T	c.(1534-1536)atC>atT	p.I512I	HEATR6_ENST00000585976.1_Silent_p.I512I	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	512							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TGCTGCAAGCGATCATTACGG	0.443													82	153					0	0	1	0	0	A	58137338	G	A	58137338	2	1	48	1	0	0	0	0	0	0	0	1	7073	1048	37	1		1	HEATR6	17	58137338	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	546	58137338	23057872	3664	8058										
HEATR6	63897	broad.mit.edu	37	chr17	58137400	58137400	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtatcttcagcaacagaaaGaaactgctttgagccttcca	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:58137400G>T	ENST00000184956.6	-	10	1490	c.1474C>A	c.(1474-1476)Ctt>Att	p.L492I	HEATR6_ENST00000585976.1_Missense_Mutation_p.L492I	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	492							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GCAACAGAAAGAAACTGCTTT	0.433													21	128					1.87028e-06	2.10206e-06	1	1	0	T	58137400	G	T	58137400	3	4	48	1	0	0	0	0	1	0	0	0	7073	942	33	2	2115	2	HEATR6	17	58137400	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	62	58137400	23057810	3665	8059										
HEATR6	63897	broad.mit.edu	37	chr17	58153597	58153597	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacaagaagagcactaacgTcctaccaaaaaaaaaaagat	7	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:58153597T>C	ENST00000184956.6	-	2	237	c.219_splice	c.e2-1	p.D74_splice	HEATR6_ENST00000585976.1_Splice_Site_p.D74_splice	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	74							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			AGCACTAACGTCCTACCAAAA	0.368													9	22					0	0	1	0	0	C	58153597	T	C	58153597	5	2	48	1	0	0	0	0	0	0	1	0	7073	1681	58	4	3400	4	HEATR6	17	58153597	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	16197	58153597	23041613	3666	8060										
APPBP2	10513	broad.mit.edu	37	chr17	58525055	58525055	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctgtcactgaatattgccGatctcgcaaccggttccagt	8	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:58525055G>A	ENST00000083182.3	-	13	1932	c.1645C>T	c.(1645-1647)Cgg>Tgg	p.R549W		NM_006380.2	NP_006371.2	Q92624	APBP2_HUMAN	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	549					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(17)|pancreas(1)|urinary_tract(1)	25	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			GAATATTGCCGATCTCGCAAC	0.443													53	119					0	0	1	0	0	A	58525055	G	A	58525055	3	1	48	1	0	0	0	0	1	0	0	0	813	1057	37	1	116	1	APPBP2	17	58525055	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	371458	58525055	22670155	3667	8061										
BCAS3	54828	broad.mit.edu	37	chr17	58824611	58824611	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgacatggcccaattcgagCggctagaatcttgcctgctc	10	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:58824611C>T	ENST00000589222.1	+	6	442	c.374C>T	c.(373-375)gCg>gTg	p.A125V	BCAS3_ENST00000408905.3_Missense_Mutation_p.A125V|BCAS3_ENST00000407086.3_Missense_Mutation_p.A125V|BCAS3_ENST00000390652.5_Missense_Mutation_p.A125V|BCAS3_ENST00000588462.1_Missense_Mutation_p.A125V			Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3	125						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			CCAATTCGAGCGGCTAGAATC	0.428													45	87					0	0	1	0	0	T	58824611	C	T	58824611	3	4	48	1	0	0	0	0	1	0	0	0	1350	768	27	1	392	1	BCAS3	17	58824611	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	299556	58824611	22370599	3668	8062										
TBX4	9496	broad.mit.edu	37	chr17	59560407	59560407	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagtgaggtgacccccagaGaagcatgtatgtactcaggt	13	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:59560407G>T	ENST00000393853.4	+	9	1334	c.1171G>T	c.(1171-1173)Gaa>Taa	p.E391*	TBX4_ENST00000589449.1_3'UTR|TBX4_ENST00000240335.1_Nonsense_Mutation_p.E390*			P57082	TBX4_HUMAN	T-box 4	390					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GACCCCCAGAGAAGCATGTAT	0.607													28	54					1.68575e-08	1.99097e-08	1	1	0	T	59560407	G	T	59560407	4	4	48	1	0	0	0	0	0	1	0	0	15719	943	33	2	1198	2	TBX4	17	59560407	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	735796	59560407	21634803	3669	8063										
BRIP1	83990	broad.mit.edu	37	chr17	59886056	59886056	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatccttcttaatggtattCgatgactcttgactgtttcc	7	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:59886056C>T	ENST00000259008.2	-	7	957	c.690G>A	c.(688-690)tcG>tcA	p.S230S	BRIP1_ENST00000577598.1_Silent_p.S230S	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	230	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						TAATGGTATTCGATGACTCTT	0.408			"F, N, Mis"			"AML, leukemia, breast"		Involved in tolerance or repair of DNA crosslinks					23	38					0	0	1	0	0	T	59886056	C	T	59886056	2	4	48	1	0	0	0	0	0	0	0	1	1516	871	31	1		1	BRIP1	17	59886056	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	325649	59886056	21309154	3670	8064										
MED13	9969	broad.mit.edu	37	chr17	60040120	60040120	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctatcactcttacctgtacaGaaacagtactcttgatatga	5	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:60040120G>A	ENST00000397786.2	-	21	5133	c.5057C>T	c.(5056-5058)tCt>tTt	p.S1686F		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1686					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TACCTGTACAGAAACAGTACT	0.368													20	47					0	0	1	0	0	A	60040120	G	A	60040120	3	1	48	1	0	0	0	0	1	0	0	0	9479	942	33	3	1507	3	MED13	17	60040120	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	154064	60040120	21155090	3671	8065										
TLK2	11011	broad.mit.edu	37	chr17	60631070	60631070	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcactagaaaacagtaagaAttctgacttagagaagaagg	10	5	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:60631070A>C	ENST00000582809.1	+	10	930	c.227A>C	c.(226-228)aAt>aCt	p.N76T	TLK2_ENST00000542523.1_Missense_Mutation_p.N193T|TLK2_ENST00000326270.9_Missense_Mutation_p.N225T|TLK2_ENST00000343388.7_Missense_Mutation_p.N193T|TLK2_ENST00000346027.5_Missense_Mutation_p.N225T			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	225					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						AACAGTAAGAATTCTGACTTA	0.299													3	25					0	0	1	0	0	C	60631070	A	C	60631070	3	2	48	1	0	0	0	0	1	0	0	0	16003	101	4	4	704	4	TLK2	17	60631070	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	590950	60631070	20564140	3672	8066										
TANC2	26115	broad.mit.edu	37	chr17	61497761	61497761	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacttccggtccagtagttCtgtaggctctcccactagac	9	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:61497761C>A	ENST00000424789.2	+	25	4422	c.4418C>A	c.(4417-4419)tCt>tAt	p.S1473Y	RP11-269G24.3_ENST00000583552.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.S1483Y	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1473							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						TCCAGTAGTTCTGTAGGCTCT	0.552													33	53					4.3181e-19	5.86915e-19	1	1	0	A	61497761	C	A	61497761	3	1	48	1	0	0	0	0	1	0	0	0	15601	913	32	2	4516	2	TANC2	17	61497761	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	866691	61497761	19697449	3673	8067										
ACE	1636	broad.mit.edu	37	chr17	61555323	61555323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgctcagccaggagtttgCggaggcctggggccagaagg	17	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:61555323C>T	ENST00000290866.4	+	2	305	c.281C>T	c.(280-282)gCg>gTg	p.A94V	ACE_ENST00000538928.1_Missense_Mutation_p.A94V|ACE_ENST00000428043.1_Missense_Mutation_p.A94V|ACE_ENST00000584529.1_3'UTR	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	94	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAGGAGTTTGCGGAGGCCTGG	0.617													7	14					0	0	1	0	0	T	61555323	C	T	61555323	3	4	48	1	0	0	0	0	1	0	0	0	136	768	27	1	287	1	ACE	17	61555323	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	57562	61555323	19639887	3674	8068										
ACE	1636	broad.mit.edu	37	chr17	61571794	61571794	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggtgactttgacccagggGccaagttccacattccttct	9	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:61571794G>T	ENST00000577647.1	+	11	1666	c.1621G>T	c.(1621-1623)Gcc>Tcc	p.A541S	ACE_ENST00000428043.1_Missense_Mutation_p.A1115S|ACE_ENST00000290866.4_Missense_Mutation_p.A1115S|ACE_ENST00000290863.6_Missense_Mutation_p.A541S|ACE_ENST00000421982.2_Missense_Mutation_p.A361S|ACE_ENST00000413513.3_Missense_Mutation_p.A541S|ACE_ENST00000490216.2_Missense_Mutation_p.A541S			P12821	ACE_HUMAN	angiotensin I converting enzyme	1115	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TGACCCAGGGGCCAAGTTCCA	0.547													11	25					0.0135373	0.0139058	1	1	0	T	61571794	G	T	61571794	3	4	48	1	0	0	0	0	1	0	0	0	136	1203	42	5	3632	5	ACE	17	61571794	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16471	61571794	19623416	3675	8069										
KCNH6	81033	broad.mit.edu	37	chr17	61601590	61601590	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaactcttcggctactcccGagtggaggtgatgcagcaac	12	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:61601590G>A	ENST00000583023.1	+	2	178	c.167G>A	c.(166-168)cGa>cAa	p.R56Q	KCNH6_ENST00000580652.1_Missense_Mutation_p.R56Q|KCNH6_ENST00000314672.5_Missense_Mutation_p.R56Q|KCNH6_ENST00000581784.1_Missense_Mutation_p.R56Q|KCNH6_ENST00000456941.2_Missense_Mutation_p.R56Q	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	56	PAS.				regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GGCTACTCCCGAGTGGAGGTG	0.617													71	125					0	0	1	0	0	A	61601590	G	A	61601590	3	1	48	1	0	0	0	0	1	0	0	0	8079	1058	37	1	173	1	KCNH6	17	61601590	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29796	61601590	19593620	3676	8070										
SCN4A	6329	broad.mit.edu	37	chr17	62021173	62021173	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatggcgttatagtatttcTtctgttcctccgtcataaag	7	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:62021173T>G	ENST00000578147.1	-	22	4026	c.3950A>C	c.(3949-3951)aAg>aCg	p.K1317T	SCN4A_ENST00000435607.1_Missense_Mutation_p.K1317T			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1317					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ATAGTATTTCTTCTGTTCCTC	0.547													12	25					0	0	1	0	0	G	62021173	T	G	62021173	3	3	48	1	0	0	0	0	1	0	0	0	13973	1609	56	4	1572	4	SCN4A	17	62021173	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	419583	62021173	19174037	3677	8071										
SCN4A	6329	broad.mit.edu	37	chr17	62034759	62034759	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcatgcccaccacggcgaaGatgaacacgatgatagccag	11	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:62034759G>A	ENST00000578147.1	-	13	2215	c.2139C>T	c.(2137-2139)atC>atT	p.I713I	SCN4A_ENST00000435607.1_Silent_p.I713I			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	713					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCACGGCGAAGATGAACACGA	0.557													24	53					0	0	1	0	0	A	62034759	G	A	62034759	2	1	48	1	0	0	0	0	0	0	0	1	13973	932	33	3		3	SCN4A	17	62034759	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13586	62034759	19160451	3678	8072										
NOL11	25926	broad.mit.edu	37	chr17	65722653	65722653	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaatcagagcttagttaaaTcactgctgctcaaggctgtt	8	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:65722653T>A	ENST00000253247.4	+	7	857	c.742T>A	c.(742-744)Tca>Aca	p.S248T	NOL11_ENST00000535137.1_Missense_Mutation_p.S66T	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	248						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTTAGTTAAATCACTGCTGCT	0.458													16	37					0	0	1	0	0	A	65722653	T	A	65722653	3	1	48	1	0	0	0	0	1	0	0	0	10567	1435	50	4	768	4	NOL11	17	65722653	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	3687894	65722653	15472557	3679	8073										
ARSG	22901	broad.mit.edu	37	chr17	66303753	66303753	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagaagccaaactttgtgaTtattttggccgatgacatgg	10	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:66303753T>C	ENST00000448504.2	+	2	915	c.119T>C	c.(118-120)aTt>aCt	p.I40T	ARSG_ENST00000452479.2_Intron	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	40					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			AACTTTGTGATTATTTTGGCC	0.473													5	66					0	0	1	0	0	C	66303753	T	C	66303753	3	2	48	1	0	0	0	0	1	0	0	0	991	1493	52	4	121	4	ARSG	17	66303753	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	581100	66303753	14891457	3680	8074										
ABCA8	10351	broad.mit.edu	37	chr17	66872602	66872602	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgtggtaatgttcctcaccAcatttgctgctgcccctcgg	9	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:66872602A>G	ENST00000269080.2	-	33	4386	c.4250_splice	c.e33+1	p.W1417_splice	ABCA8_ENST00000430352.2_Splice_Site_p.W1457_splice|ABCA8_ENST00000586539.1_Splice_Site_p.W1457_splice	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1417	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GTTCCTCACCACATTTGCTGC	0.527													5	94					0	0	1	0	0	G	66872602	A	G	66872602	5	3	48	1	0	0	0	0	0	0	1	0	38	173	6	4	520	4	ABCA8	17	66872602	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	568849	66872602	14322608	3681	8075										
ABCA8	10351	broad.mit.edu	37	chr17	66887695	66887695	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgatgttaaaaccagccagaAcatgatatatgccaggaatc	8	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:66887695A>G	ENST00000269080.2	-	22	3096	c.2959T>C	c.(2959-2961)Ttc>Ctc	p.F987L	ABCA8_ENST00000430352.2_Missense_Mutation_p.F1027L|ABCA8_ENST00000586539.1_Missense_Mutation_p.F1027L	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	987						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					ACCAGCCAGAACATGATATAT	0.363													4	13					0	0	1	0	0	G	66887695	A	G	66887695	3	3	48	1	0	0	0	0	1	0	0	0	38	43	2	4	1854	4	ABCA8	17	66887695	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	15093	66887695	14307515	3682	8076										
ABCA8	10351	broad.mit.edu	37	chr17	66903902	66903902	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggaaatttatttgttctttCtaagggtaatgtataaataa	7	2	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:66903902C>A	ENST00000269080.2	-	16	2274	c.2137G>T	c.(2137-2139)Gaa>Taa	p.E713*	ABCA8_ENST00000430352.2_Nonsense_Mutation_p.E753*|ABCA8_ENST00000586539.1_Nonsense_Mutation_p.E753*	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	713						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TTTGTTCTTTCTAAGGGTAAT	0.303													6	9					3.59834e-05	3.93264e-05	1	1	0	A	66903902	C	A	66903902	4	1	48	1	0	0	0	0	0	1	0	0	38	922	32	2	2700	2	ABCA8	17	66903902	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16207	66903902	14291308	3683	8077										
ABCA6	23460	broad.mit.edu	37	chr17	67111054	67111054	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtcttgcatttcagagagaTttttattatagatggtaact	8	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:67111054T>C	ENST00000284425.2	-	13	1805	c.1631A>G	c.(1630-1632)aAt>aGt	p.N544S		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	544	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TTCAGAGAGATTTTTATTATA	0.308													15	27					0	0	1	0	0	C	67111054	T	C	67111054	3	2	48	1	0	0	0	0	1	0	0	0	36	1493	52	4	3330	4	ABCA6	17	67111054	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	207152	67111054	14084156	3684	8078										
ABCA5	23461	broad.mit.edu	37	chr17	67257334	67257334	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatacaaaaggcataatgaaGaatagttgcaattgtgtatc	9	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:67257334G>A	ENST00000392676.3	-	26	3560	c.3496C>T	c.(3496-3498)Ctt>Ttt	p.L1166F	ABCA5_ENST00000392677.2_Missense_Mutation_p.L1167F|ABCA5_ENST00000588877.1_Missense_Mutation_p.L1166F			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1166					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					GCATAATGAAGAATAGTTGCA	0.289													4	27					0	0	1	0	0	A	67257334	G	A	67257334	3	1	48	1	0	0	0	0	1	0	0	0	35	942	33	3	1488	3	ABCA5	17	67257334	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	146280	67257334	13937876	3685	8079										
ABCA5	23461	broad.mit.edu	37	chr17	67270154	67270154	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatgtggtttgtctccagGttttagaaaatataagtctg	9	4	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:67270154G>T	ENST00000392676.3	-	20	2774	c.2710C>A	c.(2710-2712)Cct>Act	p.P904T	ABCA5_ENST00000392677.2_Missense_Mutation_p.P904T|ABCA5_ENST00000588877.1_Missense_Mutation_p.P904T			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	904					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TTGTCTCCAGGTTTTAGAAAA	0.363													17	43					5.01169e-05	5.45927e-05	1	1	0	T	67270154	G	T	67270154	3	4	48	1	0	0	0	0	1	0	0	0	35	1261	44	5	2298	5	ABCA5	17	67270154	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	12820	67270154	13925056	3686	8080										
ABCA5	23461	broad.mit.edu	37	chr17	67302906	67302906	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccattatctttaaaaattCttttatttttttttcttttt	0	6	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:67302906C>A	ENST00000392676.3	-	6	812	c.748G>T	c.(748-750)Gaa>Taa	p.E250*	ABCA5_ENST00000392677.2_Nonsense_Mutation_p.E250*|ABCA5_ENST00000588877.1_Nonsense_Mutation_p.E250*			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	250					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TTTAAAAATTCTTTTATTTTT	0.239													7	17					0.27861	0.279356	1	1	0	A	67302906	C	A	67302906	4	1	48	1	0	0	0	0	0	1	0	0	35	922	32	2	4316	2	ABCA5	17	67302906	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	32752	67302906	13892304	3687	8081										
SDK2	54549	broad.mit.edu	37	chr17	71334925	71334925	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgtggtctggctcacccGagtcgctctccgtgtagctg	14	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:71334925G>A	ENST00000392650.3	-	45	6320	c.6320C>T	c.(6319-6321)tCg>tTg	p.S2107L	SDK2_ENST00000388726.3_Missense_Mutation_p.S2088L|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2107					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TGGCTCACCCGAGTCGCTCTC	0.627													15	23					0	0	1	0	0	A	71334925	G	A	71334925	3	1	48	1	0	0	0	0	1	0	0	0	14022	1059	37	1	202	1	SDK2	17	71334925	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4032019	71334925	9860285	3688	8082										
SDK2	54549	broad.mit.edu	37	chr17	71390374	71390374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccagcacgagcccgttgcGatcagcctcggggacctcgc	13	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:71390374G>A	ENST00000392650.3	-	26	3682	c.3682C>T	c.(3682-3684)Cgc>Tgc	p.R1228C	SDK2_ENST00000388726.3_Missense_Mutation_p.R1228C	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1228	Fibronectin type-III 7.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						AGCCCGTTGCGATCAGCCTCG	0.657													8	15					0	0	1	0	0	A	71390374	G	A	71390374	3	1	48	1	0	0	0	0	1	0	0	0	14022	1058	37	1	2916	1	SDK2	17	71390374	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	55449	71390374	9804836	3689	8083										
RPL38	6169	broad.mit.edu	37	chr17	72205359	72205359	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaaaataaggacaacgtgaAgtttaaagttcgatgcagca	10	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:72205359A>C	ENST00000311111.6	+	4	229	c.98A>C	c.(97-99)aAg>aCg	p.K33T	RPL38_ENST00000533498.1_Missense_Mutation_p.K33T|RPL38_ENST00000584577.1_Missense_Mutation_p.K33T|RPL38_ENST00000534490.1_Missense_Mutation_p.K33T|RPL38_ENST00000439590.2_Missense_Mutation_p.K33T			P63173	RL38_HUMAN	ribosomal protein L38	33					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			large_intestine(1)|pancreas(1)	2						GACAACGTGAAGTTTAAAGTT	0.458													9	107					0	0	1	0	0	C	72205359	A	C	72205359	3	2	48	1	0	0	0	0	1	0	0	0	13642	72	3	4	108	4	RPL38	17	72205359	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	814985	72205359	8989851	3690	8084										
KIF19	124602	broad.mit.edu	37	chr17	72350678	72350678	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaagcggaggtcccgatccTtcgaggtcaccgggcaaggg	17	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:72350678T>G	ENST00000389916.4	+	18	2824	c.2686T>G	c.(2686-2688)Ttc>Gtc	p.F896V		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	896					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GTCCCGATCCTTCGAGGTCAC	0.642													4	4					0	0	1	0	0	G	72350678	T	G	72350678	3	3	48	1	0	0	0	0	1	0	0	0	8323	1609	56	4	2756	4	KIF19	17	72350678	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	145319	72350678	8844532	3691	8085										
CD300C	10871	broad.mit.edu	37	chr17	72539095	72539095	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacctgaggtgcccatggaGctctgggggctggaggctgt	19	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:72539095G>A	ENST00000330793.1	-	3	792	c.432C>T	c.(430-432)agC>agT	p.S144S		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	144	Pro-rich.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						TGCCCATGGAGCTCTGGGGGC	0.622													26	37					0	0	1	0	0	A	72539095	G	A	72539095	2	1	48	1	0	0	0	0	0	0	0	1	3019	962	34	3		3	CD300C	17	72539095	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	188417	72539095	8656115	3692	8086										
FDXR	2232	broad.mit.edu	37	chr17	72860427	72860427	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggcttctctgtggccgttCgaagcagcagttccgtcagc	12	13	2	0	rs111830964		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:72860427C>T	ENST00000455107.2	-	10	1129	c.713G>A	c.(712-714)cGa>cAa	p.R238Q	FDXR_ENST00000442102.2_Missense_Mutation_p.R325Q|FDXR_ENST00000413947.2_Missense_Mutation_p.R313Q|FDXR_ENST00000544854.1_Missense_Mutation_p.R230Q|FDXR_ENST00000583917.1_Missense_Mutation_p.R254Q|FDXR_ENST00000420580.2_Missense_Mutation_p.R242Q|FDXR_ENST00000582944.1_Missense_Mutation_p.R274Q|FDXR_ENST00000293195.5_Missense_Mutation_p.R282Q|FDXR_ENST00000581530.1_Missense_Mutation_p.R288Q			P22570	ADRO_HUMAN	ferredoxin reductase	282					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TGTGGCCGTTCGAAGCAGCAG	0.687													15	28					0	0	1	0	0	T	72860427	C	T	72860427	3	4	48	1	0	0	0	0	1	0	0	0	5839	884	31	1	646	1	FDXR	17	72860427	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	321332	72860427	8334783	3693	8087										
SEPT9	10801	broad.mit.edu	37	chr17	75398271	75398271	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccaggacctgggcgtgaaGaactcagaaccctcggcccg	12	14	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:75398271G>T	ENST00000329047.8	+	2	965	c.153G>T	c.(151-153)aaG>aaT	p.K51N	SEPT9_ENST00000449803.2_5'UTR|SEPT9_ENST00000431235.2_5'UTR|SEPT9_ENST00000591198.1_Missense_Mutation_p.K50N|SEPT9_ENST00000588690.1_5'UTR|SEPT9_ENST00000423034.2_Missense_Mutation_p.K62N|SEPT9_ENST00000427674.2_5'UTR|SEPT9_ENST00000592420.1_5'UTR|SEPT9_ENST00000427177.1_Missense_Mutation_p.K69N|SEPT9_ENST00000590294.1_Missense_Mutation_p.K51N	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	69					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			TGGGCGTGAAGAACTCAGAAC	0.672													26	43					3.73808e-20	5.11168e-20	1	1	0	T	75398271	G	T	75398271	3	4	48	1	0	0	0	0	1	0	0	0	14124	933	33	2	302	2	SEPT9	17	75398271	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2537844	75398271	5796939	3694	8088										
DNAH17	8632	broad.mit.edu	37	chr17	76503679	76503679	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatggagatgacggagtccGccgtggacagcttctgctgc	15	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:76503679G>A	ENST00000389840.5	-	28	4557	c.4433C>T	c.(4432-4434)gCg>gTg	p.A1478V	DNAH17_ENST00000585328.1_Missense_Mutation_p.A1479V					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GACGGAGTCCGCCGTGGACAG	0.602													22	27					0	0	1	0	0	A	76503679	G	A	76503679	3	1	48	1	0	0	0	0	1	0	0	0	4629	1087	38	1	9159	1	DNAH17	17	76503679	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1105408	76503679	4691531	3695	8089										
USP36	57602	broad.mit.edu	37	chr17	76799474	76799474	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctgcccttacctgtgccGaagtgggtcctggtgcaggc	13	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:76799474G>A	ENST00000312010.6	-	16	3127	c.2803C>T	c.(2803-2805)Cgg>Tgg	p.R935W	USP36_ENST00000542802.2_Missense_Mutation_p.R935W|USP36_ENST00000449938.2_Missense_Mutation_p.R540W	NM_025090.3	NP_079366.3	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	935					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			TACCTGTGCCGAAGTGGGTCC	0.562													19	50					0	0	1	0	0	A	76799474	G	A	76799474	3	1	48	1	0	0	0	0	1	0	0	0	17126	1057	37	1	588	1	USP36	17	76799474	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	295795	76799474	4395736	3696	8090										
ENGASE	64772	broad.mit.edu	37	chr17	77073826	77073826	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcttggcgtggaagccccGcttggaggatggctttaatg	15	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:77073826G>A	ENST00000579016.1	+	3	296	c.296G>A	c.(295-297)cGc>cAc	p.R99H	ENGASE_ENST00000539857.2_5'UTR	NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	99						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	p.A95_L100delAWKPRL(1)		breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						TGGAAGCCCCGCTTGGAGGAT	0.557													33	59					0	0	1	0	0	A	77073826	G	A	77073826	3	1	48	1	0	0	0	0	1	0	0	0	5146	1087	38	1	306	1	ENGASE	17	77073826	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	274352	77073826	4121384	3697	8091										
GAA	2548	broad.mit.edu	37	chr17	78078718	78078718	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcccgcggctgttgctacatCcctgcaaagcaggggctgca	13	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:78078718C>T	ENST00000302262.3	+	2	552	c.333C>T	c.(331-333)atC>atT	p.I111I	GAA_ENST00000390015.3_Silent_p.I111I	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	111	P-type.				cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GTTGCTACATCCCTGCAAAGC	0.647													15	23					0	0	1	0	0	T	78078718	C	T	78078718	2	4	48	1	0	0	0	0	0	0	0	1	6181	845	30	3		3	GAA	17	78078718	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1004892	78078718	3116492	3698	8092										
RNF213	57674	broad.mit.edu	37	chr17	78353468	78353468	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcattgactgccatgcgccgAttggaggcattgaccacaaa	11	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:78353468A>C	ENST00000582970.1	+	55	13737	c.13594A>C	c.(13594-13596)Att>Ctt	p.I4532L	RNF213_ENST00000336301.6_Missense_Mutation_p.I2605L|CTD-2047H16.4_ENST00000572151.1_RNA|CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000508628.2_Missense_Mutation_p.I4581L	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CCATGCGCCGATTGGAGGCAT	0.507													21	47					0	0	1	0	0	C	78353468	A	C	78353468	3	2	48	1	0	0	0	0	1	0	0	0	13528	333	12	4	14127	4	RNF213	17	78353468	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	274750	78353468	2841742	3699	8093										
FASN	2194	broad.mit.edu	37	chr17	80049219	80049219	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcggtggcggggacagccgcGatgtcgttcagcatgctcag	17	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:80049219G>A	ENST00000306749.2	-	9	1589	c.1371C>T	c.(1369-1371)atC>atT	p.I457I		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	457	Acyl and malonyl transferases (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGACAGCCGCGATGTCGTTCA	0.711													6	16					0	0	1	0	0	A	80049219	G	A	80049219	2	1	48	1	0	0	0	0	0	0	0	1	5715	1048	37	1		1	FASN	17	80049219	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1695751	80049219	1145991	3700	8094										
HEXDC	284004	broad.mit.edu	37	chr17	80377718	80377718	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgagattagttcatttaGaccttaaaggagctccacca	8	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:80377718G>A	ENST00000337014.6	+	2	517	c.43G>A	c.(43-45)Gac>Aac	p.D15N	HEXDC_ENST00000327949.9_Missense_Mutation_p.D15N|HEXDC_ENST00000577944.1_Missense_Mutation_p.D15N	NM_173620.2	NP_775891.2	Q8WVB3	HEXDC_HUMAN	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	15					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			AGTTCATTTAGACCTTAAAGG	0.433													8	36					0	0	1	0	0	A	80377718	G	A	80377718	3	1	48	1	0	0	0	0	1	0	0	0	7115	942	33	3	45	3	HEXDC	17	80377718	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	328499	80377718	817492	3701	8095										
RAB40B	10966	broad.mit.edu	37	chr17	80617462	80617462	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctacaacatacctcatcGatctccttaatccatcgatc	2	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr17:80617462G>A	ENST00000571995.1	-	4	467	c.336C>T	c.(334-336)atC>atT	p.I112I	RAB40B_ENST00000269347.6_5'UTR|RAB40B_ENST00000538809.2_Silent_p.I112I	NM_006822.2	NP_006813.1	Q12829	RB40B_HUMAN	RAB40B, member RAS oncogene family	112					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(2)	10	Breast(20;0.00132)|all_neural(118;0.0952)	all_cancers(8;0.072)|all_epithelial(8;0.139)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			ATACCTCATCGATCTCCTTAA	0.562													19	42					0	0	1	0	0	A	80617462	G	A	80617462	2	1	48	1	0	0	0	0	0	0	0	1	12992	1048	37	1		1	RAB40B	17	80617462	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	239744	80617462	577748	3702	8096										
CETN1	1068	broad.mit.edu	37	chr18	580627	580627	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagagatgaagaaaatgatCtccgaggtggacagggaagg	16	4	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:580627C>A	ENST00000327228.3	+	1	261	c.219C>A	c.(217-219)atC>atA	p.I73I		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	73	EF-hand 2.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						AGAAAATGATCTCCGAGGTGG	0.552													20	37					2.37509e-13	3.04217e-13	1	1	0	A	580627	C	A	580627	2	1	48	1	0	0	0	0	0	0	0	1	3296	903	32	2		2	CETN1	18	580627	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		580627	77496621	3703	8097										
YES1	7525	broad.mit.edu	37	chr18	736808	736808	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatgtaaaagtaattttacCttgtcttgctgtgtattcat	6	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:736808C>T	ENST00000584307.1	-	10	1461	c.1291_splice	c.e10+1	p.G431_splice	RP11-769O8.1_ENST00000583314.1_RNA|YES1_ENST00000577961.1_Splice_Site_p.G436_splice|YES1_ENST00000314574.4_Splice_Site_p.G431_splice			P07947	YES_HUMAN	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	431	Protein kinase.				blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)	17					Dasatinib(DB01254)	GTAATTTTACCTTGTCTTGCT	0.343													5	27					0	0	1	0	0	T	736808	C	T	736808	5	4	48	1	0	0	0	0	0	0	1	0	17533	695	24	3	352	3	YES1	18	736808	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	156181	736808	77340440	3704	8098										
SMCHD1	23347	broad.mit.edu	37	chr18	2778221	2778221	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggataatctggatgcggccaAtcattatagaaaagaggtat	11	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:2778221A>C	ENST00000320876.6	+	44	5869	c.5531A>C	c.(5530-5532)aAt>aCt	p.N1844T	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Missense_Mutation_p.N1844T	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1844					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						GATGCGGCCAATCATTATAGA	0.279													7	8					0	0	1	0	0	C	2778221	A	C	2778221	3	2	48	1	0	0	0	0	1	0	0	0	14841	101	4	4	5705	4	SMCHD1	18	2778221	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2041413	2778221	75299027	3705	8099										
EMILIN2	84034	broad.mit.edu	37	chr18	2890578	2890578	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataatgaacccagccaattCtcagagcccaggaagacttt	8	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:2890578C>A	ENST00000254528.3	+	4	612	c.453C>A	c.(451-453)ttC>ttA	p.F151L		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	151					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		CCAGCCAATTCTCAGAGCCCA	0.443													21	54					1.2644e-06	1.4261e-06	1	1	0	A	2890578	C	A	2890578	3	1	48	1	0	0	0	0	1	0	0	0	5122	912	32	2	467	2	EMILIN2	18	2890578	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	112357	2890578	75186670	3706	8100										
MYOM1	8736	broad.mit.edu	37	chr18	3151809	3151809	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagatataggaacgaccttCgatcaatccagtgacaggaa	10	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:3151809C>T	ENST00000356443.4	-	12	2059	c.1726G>A	c.(1726-1728)Gaa>Aaa	p.E576K	MYOM1_ENST00000261606.7_Missense_Mutation_p.E576K|MYOM1_ENST00000400569.3_Missense_Mutation_p.E576K	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	576	Fibronectin type-III 1.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GAACGACCTTCGATCAATCCA	0.507											OREG0024839	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	39					0	0	1	0	0	T	3151809	C	T	3151809	3	4	48	1	0	0	0	0	1	0	0	0	10138	893	31	1	3439	1	MYOM1	18	3151809	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	261231	3151809	74925439	3707	8101										
PTPRM	5797	broad.mit.edu	37	chr18	7955218	7955218	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcaatggggatgggcccaTtgtggcccgagaggtggagt	17	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:7955218T>C	ENST00000332175.8	+	7	1975	c.938T>C	c.(937-939)aTt>aCt	p.I313T	PTPRM_ENST00000400053.4_Missense_Mutation_p.I251T|PTPRM_ENST00000400060.4_Missense_Mutation_p.I313T|PTPRM_ENST00000444013.1_Missense_Mutation_p.I100T|PTPRM_ENST00000580170.1_Missense_Mutation_p.I313T	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	313	Fibronectin type-III 1.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GATGGGCCCATTGTGGCCCGA	0.577													5	53					0	0	1	0	0	C	7955218	T	C	7955218	3	2	48	1	0	0	0	0	1	0	0	0	12857	1493	52	4	964	4	PTPRM	18	7955218	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4803409	7955218	70122030	3708	8102										
PTPRM	5797	broad.mit.edu	37	chr18	8143718	8143718	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttaaaattgctggagtcatCgcgggcatcttgctgttcgt	12	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:8143718C>T	ENST00000332175.8	+	14	3278	c.2241C>T	c.(2239-2241)atC>atT	p.I747I	PTPRM_ENST00000400053.4_Silent_p.I685I|PTPRM_ENST00000400060.4_Silent_p.I747I|PTPRM_ENST00000444013.1_Silent_p.I534I|PTPRM_ENST00000580170.1_Silent_p.I747I	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	747					homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CTGGAGTCATCGCGGGCATCT	0.438													46	76					0	0	1	0	0	T	8143718	C	T	8143718	2	4	48	1	0	0	0	0	0	0	0	1	12857	874	31	1		1	PTPRM	18	8143718	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	188500	8143718	69933530	3709	8103										
PTPRM	5797	broad.mit.edu	37	chr18	8406109	8406109	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccctcctgttttccaggaTcagtacaagttctgctacga	7	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:8406109T>G	ENST00000332175.8	+	31	5345	c.4308T>G	c.(4306-4308)gaT>gaG	p.D1436E	PTPRM_ENST00000400053.4_Missense_Mutation_p.D1374E|PTPRM_ENST00000400060.4_Missense_Mutation_p.D1450E|PTPRM_ENST00000444013.1_Missense_Mutation_p.D1223E|PTPRM_ENST00000580170.1_Missense_Mutation_p.D1449E	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1436	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				TTTTCCAGGATCAGTACAAGT	0.443													14	31					0	0	1	0	0	G	8406109	T	G	8406109	3	3	48	1	0	0	0	0	1	0	0	0	12857	1432	50	4	4477	4	PTPRM	18	8406109	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	262391	8406109	69671139	3710	8104										
NDUFV2	4729	broad.mit.edu	37	chr18	9134277	9134277	+	Nonstop_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgtacaagcaggcctttaAtttatattgaactgtaaata	8	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:9134277A>C	ENST00000400033.1	+	9	876	c.759A>C	c.(757-759)taA>taC	p.*253Y	RP11-21J18.1_ENST00000579126.1_RNA|NDUFV2_ENST00000465096.1_3'UTR|NDUFV2_ENST00000318388.6_Nonstop_Mutation_p.*250Y|RP11-143J12.2_ENST00000582375.1_RNA			P19404	NDUV2_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	0					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|lung(4)|ovary(1)|stomach(1)	7					NADH(DB00157)	CAGGCCTTTAATTTATATTGA	0.403													15	29					0	0	1	0	0	C	9134277	A	C	9134277	4	2	48	1	0	0	0	0	0	0	0	0	10346	108	4	4	780	4	NDUFV2	18	9134277	Nonstop_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	728168	9134277	68942971	3711	8105										
SPIRE1	56907	broad.mit.edu	37	chr18	12512515	12512515	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgctcttttccatttcttGaatcttcttaagattctaca	3	10	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:12512515G>T	ENST00000409402.4	-	5	1012	c.745C>A	c.(745-747)Caa>Aaa	p.Q249K	SPIRE1_ENST00000410092.3_Missense_Mutation_p.Q249K|SPIRE1_ENST00000383356.2_Missense_Mutation_p.Q90K|SPIRE1_ENST00000309836.5_Missense_Mutation_p.Q52K|SPIRE1_ENST00000453447.2_Missense_Mutation_p.Q129K	NM_001128626.1	NP_001122098.1	Q08AE8	SPIR1_HUMAN	spire-type actin nucleation factor 1	249			Q -> P (in dbSNP:rs1785296).			cytoskeleton|perinuclear region of cytoplasm	actin binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)	28						TCCATTTCTTGAATCTTCTTA	0.338													9	24					1.58986e-06	1.78832e-06	1	1	0	T	12512515	G	T	12512515	3	4	48	1	0	0	0	0	1	0	0	0	15126	1299	45	2	1577	2	SPIRE1	18	12512515	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3378238	12512515	65564733	3712	8106										
CEP192	55125	broad.mit.edu	37	chr18	13059163	13059163	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagaagagataaaagtgcTttttataccatccagtcctg	7	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:13059163T>C	ENST00000506447.1	+	21	4420	c.4340T>C	c.(4339-4341)cTt>cCt	p.L1447P	CEP192_ENST00000430049.2_Missense_Mutation_p.L972P|CEP192_ENST00000325971.8_Missense_Mutation_p.L851P	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1042										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATAAAAGTGCTTTTTATACCA	0.413													41	81					0	0	1	0	0	C	13059163	T	C	13059163	3	2	48	1	0	0	0	0	1	0	0	0	3273	1609	56	4	4418	4	CEP192	18	13059163	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	546648	13059163	65018085	3713	8107										
ESCO1	114799	broad.mit.edu	37	chr18	19144267	19144267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttaggcaaagaatgatttCgtggtgtctcccttaaaaaa	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:19144267C>T	ENST00000269214.5	-	7	2655	c.1718G>A	c.(1717-1719)cGa>cAa	p.R573Q		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	573					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding	p.R573Q(1)		breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						AGAATGATTTCGTGGTGTCTC	0.294													5	13					0	0	1	0	0	T	19144267	C	T	19144267	3	4	48	1	0	0	0	0	1	0	0	0	5276	884	31	1	828	1	ESCO1	18	19144267	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	6085104	19144267	58932981	3714	8108										
NPC1	4864	broad.mit.edu	37	chr18	21136259	21136259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaagggtacatcagctcccGaagggtatggctggtaaatg	13	8	1	0	rs140149624		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:21136259G>A	ENST00000269228.5	-	8	1828	c.1274C>T	c.(1273-1275)tCg>tTg	p.S425L	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.S175L	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	425					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATCAGCTCCCGAAGGGTATGG	0.498													24	54					0	0	1	0	0	A	21136259	G	A	21136259	3	1	48	1	0	0	0	0	1	0	0	0	10616	1059	37	1	2634	1	NPC1	18	21136259	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1991992	21136259	56940989	3715	8109										
LAMA3	3909	broad.mit.edu	37	chr18	21330920	21330920	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacggtcgtccaggtgcaaaAaattttactttctctcacac	6	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:21330920A>C	ENST00000313654.9	+	5	964	c.723A>C	c.(721-723)aaA>aaC	p.K241N	LAMA3_ENST00000399516.3_Missense_Mutation_p.K241N	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	241	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGTGCAAAAAATTTTACTT	0.423													32	41					0	0	1	0	0	C	21330920	A	C	21330920	3	2	48	1	0	0	0	0	1	0	0	0	8645	11	1	4	741	4	LAMA3	18	21330920	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	194661	21330920	56746328	3716	8110										
LAMA3	3909	broad.mit.edu	37	chr18	21399891	21399891	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctaatgggagagaccttcGatttggatttgatccgctgg	12	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:21399891G>A	ENST00000313654.9	+	19	2475	c.2234G>A	c.(2233-2235)cGa>cAa	p.R745Q	LAMA3_ENST00000399516.3_Missense_Mutation_p.R745Q	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	745					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.R745Q(1)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGACCTTCGATTTGGATTT	0.443													19	39					0	0	1	0	0	A	21399891	G	A	21399891	3	1	48	1	0	0	0	0	1	0	0	0	8645	1058	37	1	2308	1	LAMA3	18	21399891	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	68971	21399891	56677357	3717	8111										
TTC39C	125488	broad.mit.edu	37	chr18	21644103	21644103	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtgtgtgtttttttaacaGaaatcatagcccactaatga	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:21644103G>T	ENST00000317571.3	+	2	403		c.e2-1		TTC39C_ENST00000578150.1_Splice_Site|TTC39C_ENST00000304621.6_Splice_Site	NM_001135993.1	NP_001129465.1	Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C								binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	19						TTTTTTAACAGAAATCATAGC	0.294													22	30					3.08376e-08	3.62155e-08	1	1	0	T	21644103	G	T	21644103	5	4	48	1	0	0	0	0	0	0	1	0	16770	956	33	2	173	2	TTC39C	18	21644103	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	244212	21644103	56433145	3718	8112										
CABYR	26256	broad.mit.edu	37	chr18	21736538	21736538	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacctctggcatgtctaaaaAatctgtagagtctgtaaaac	7	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:21736538A>C	ENST00000399481.2	+	2	931	c.779A>C	c.(778-780)aAa>aCa	p.K260T	CABYR_ENST00000415309.2_Intron|CABYR_ENST00000399496.3_Intron|CABYR_ENST00000581397.1_Intron|CABYR_ENST00000399499.1_Intron|CABYR_ENST00000327201.6_Intron			O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	358					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					ATGTCTAAAAAATCTGTAGAG	0.408													25	62					0	0	1	0	0	C	21736538	A	C	21736538	3	2	48	1	0	0	0	0	1	0	0	0	2554	14	1	4	1083	4	CABYR	18	21736538	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	92435	21736538	56340710	3719	8113										
OSBPL1A	114876	broad.mit.edu	37	chr18	21819302	21819302	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtctccagtgcttctgacaaGattttgtttttttcttgctc	7	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:21819302G>T	ENST00000319481.3	-	16	1532	c.1326C>A	c.(1324-1326)atC>atA	p.I442I	OSBPL1A_ENST00000399443.3_5'UTR|OSBPL1A_ENST00000357041.4_Silent_p.I60I	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	442					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTTCTGACAAGATTTTGTTTT	0.443													16	24					2.23348e-06	2.50077e-06	1	1	0	T	21819302	G	T	21819302	2	4	48	1	0	0	0	0	0	0	0	1	11323	932	33	2		2	OSBPL1A	18	21819302	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	82764	21819302	56257946	3720	8114										
IMPACT	55364	broad.mit.edu	37	chr18	22028085	22028085	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaggataaacagaccttcTtacaggattgtgaggatgat	12	5	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:22028085T>G	ENST00000284202.4	+	9	838	c.697T>G	c.(697-699)Tta>Gta	p.L233V		NM_018439.3	NP_060909.1	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein	233										endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					ACAGACCTTCTTACAGGATTG	0.353													6	68					0	0	1	0	0	G	22028085	T	G	22028085	3	3	48	1	0	0	0	0	1	0	0	0	7767	1606	56	4	731	4	IMPACT	18	22028085	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	208783	22028085	56049163	3721	8115										
TAF4B	6875	broad.mit.edu	37	chr18	23895323	23895323	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgtaaagatgaaccatttCtttttattggagctctacaa	6	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:23895323C>A	ENST00000269142.5	+	10	2961	c.1963C>A	c.(1963-1965)Ctt>Att	p.L655I	TAF4B_ENST00000578121.1_Missense_Mutation_p.L660I	NM_005640.1	NP_005631.1	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	655	Histone-fold.				transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|prostate(1)|skin(1)	29	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			TGAACCATTTCTTTTTATTGG	0.358													12	27					7.03913e-09	8.36985e-09	1	1	0	A	23895323	C	A	23895323	3	1	48	1	0	0	0	0	1	0	0	0	15583	913	32	2	2001	2	TAF4B	18	23895323	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1867238	23895323	54181925	3722	8116										
CHST9	83539	broad.mit.edu	37	chr18	24496352	24496352	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagcattggttctttcatcGgaagagtgcctatccttaaa	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:24496352G>A	ENST00000284224.8	-	6	1480	c.1203C>T	c.(1201-1203)tcC>tcT	p.S401S	CHST9_ENST00000580774.1_3'UTR|AQP4-AS1_ENST00000568797.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|AQP4-AS1_ENST00000578701.1_RNA|CHST9_ENST00000581714.1_Silent_p.S401S|AQP4-AS1_ENST00000579964.1_RNA	NM_031422.5	NP_113610.2	Q7L1S5	CHST9_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	401					carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|skin(3)	28	all_lung(6;0.0145)|Ovarian(20;0.124)					TTCTTTCATCGGAAGAGTGCC	0.368													34	77					0	0	1	0	0	A	24496352	G	A	24496352	2	1	48	1	0	0	0	0	0	0	0	1	3433	1103	39	1		1	CHST9	18	24496352	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	601029	24496352	53580896	3723	8117										
DSC3	1825	broad.mit.edu	37	chr18	28574328	28574328	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcttcattctgattacatCgatgcaatttctgtaaaatt	6	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28574328C>T	ENST00000360428.4	-	16	2584	c.2504G>A	c.(2503-2505)cGa>cAa	p.R835Q	DSC3_ENST00000434452.1_3'UTR	NM_001941.3	NP_001932.2	Q14574	DSC3_HUMAN	desmocollin 3	835					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTGATTACATCGATGCAATTT	0.318													13	23					0	0	1	0	0	T	28574328	C	T	28574328	3	4	48	1	0	0	0	0	1	0	0	0	4793	884	31	1	190	1	DSC3	18	28574328	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4077976	28574328	49502920	3724	8118										
DSC2	1824	broad.mit.edu	37	chr18	28671063	28671063	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaattggagcccatcttctCttggcgcgccttagaacttt	10	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28671063C>T	ENST00000280904.6	-	4	845	c.402G>A	c.(400-402)aaG>aaA	p.K134K	DSC2_ENST00000251081.6_Silent_p.K134K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	134					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CCCATCTTCTCTTGGCGCGCC	0.388													17	41					0	0	1	0	0	T	28671063	C	T	28671063	2	4	48	1	0	0	0	0	0	0	0	1	4792	912	32	3		3	DSC2	18	28671063	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	96735	28671063	49406185	3725	8119										
DSC1	1823	broad.mit.edu	37	chr18	28712594	28712594	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgctgggctatgtcttcTggaaaacatttcttgactgt	9	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28712594T>C	ENST00000257197.3	-	14	2436	c.2175A>G	c.(2173-2175)ccA>ccG	p.P725P	DSC1_ENST00000257198.5_Silent_p.P725P|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	725					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CTATGTCTTCTGGAAAACATT	0.343													15	37					0	0	1	0	0	C	28712594	T	C	28712594	2	2	48	1	0	0	0	0	0	0	0	1	4791	1567	55	4		4	DSC1	18	28712594	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	41531	28712594	49364654	3726	8120										
DSC1	1823	broad.mit.edu	37	chr18	28712606	28712606	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtcttctggaaaacatttCttgactgttctcttagcagt	7	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28712606C>A	ENST00000257197.3	-	14	2424	c.2163G>T	c.(2161-2163)aaG>aaT	p.K721N	DSC1_ENST00000257198.5_Missense_Mutation_p.K721N|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	721					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GAAAACATTTCTTGACTGTTC	0.333													14	35					0.00185496	0.00194308	1	1	0	A	28712606	C	A	28712606	3	1	48	1	0	0	0	0	1	0	0	0	4791	912	32	2	573	2	DSC1	18	28712606	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12	28712606	49364642	3727	8121										
DSC1	1823	broad.mit.edu	37	chr18	28720011	28720011	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaaagtacatcaccttaagCcttcaccactggatatttcc	5	12	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28720011C>A	ENST00000257197.3	-	10	1775	c.1514G>T	c.(1513-1515)gGc>gTc	p.G505V	DSC1_ENST00000257198.5_Missense_Mutation_p.G505V|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	505	Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TCACCTTAAGCCTTCACCACT	0.368													17	40					3.41278e-10	4.16994e-10	1	1	0	A	28720011	C	A	28720011	3	1	48	1	0	0	0	0	1	0	0	0	4791	739	26	5	1238	5	DSC1	18	28720011	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7405	28720011	49357237	3728	8122										
DSG4	147409	broad.mit.edu	37	chr18	28968937	28968937	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgataacgctccagtcttttCgcaaagtgtatacacagcca	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28968937C>T	ENST00000359747.4	+	5	502	c.473C>T	c.(472-474)tCg>tTg	p.S158L	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.S158L|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	158	Cadherin 2.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding	p.S158L(1)		NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCAGTCTTTTCGCAAAGTGTA	0.413													26	55					0	0	1	0	0	T	28968937	C	T	28968937	3	4	48	1	0	0	0	0	1	0	0	0	4805	893	31	1	491	1	DSG4	18	28968937	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	248926	28968937	49108311	3729	8123										
DSG4	147409	broad.mit.edu	37	chr18	28979455	28979455	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttattgaattatgtgcttgGcacatatacagccatagatt	7	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:28979455G>A	ENST00000359747.4	+	9	1255	c.1226G>A	c.(1225-1227)gGc>gAc	p.G409D	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.G409D|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	409	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TATGTGCTTGGCACATATACA	0.398													34	57					0	0	1	0	0	A	28979455	G	A	28979455	3	1	48	1	0	0	0	0	1	0	0	0	4805	1203	42	3	1260	3	DSG4	18	28979455	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10518	28979455	49097793	3730	8124										
MEP1B	4225	broad.mit.edu	37	chr18	29772619	29772619	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaatcaaagatgtagatggCggaatggaccaggacatatt	11	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:29772619C>T	ENST00000269202.6	+	3	140	c.93C>T	c.(91-93)ggC>ggT	p.G31G	MEP1B_ENST00000581447.1_Silent_p.G31G	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	31					digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						ATGTAGATGGCGGAATGGACC	0.284													39	74					0	0	1	0	0	T	29772619	C	T	29772619	2	4	48	1	0	0	0	0	0	0	0	1	9525	755	27	1		1	MEP1B	18	29772619	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	793164	29772619	48304629	3731	8125										
MEP1B	4225	broad.mit.edu	37	chr18	29797891	29797891	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggaagaaatatcgtgaaaGgatgagctcaaatcgaccaa	10	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:29797891G>T	ENST00000269202.6	+	14	2101	c.2054G>T	c.(2053-2055)aGg>aTg	p.R685M	MEP1B_ENST00000581447.1_Missense_Mutation_p.R685M	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	685					digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TATCGTGAAAGGATGAGCTCA	0.398													22	25					1.9806e-07	2.28356e-07	1	1	0	T	29797891	G	T	29797891	3	4	48	1	0	0	0	0	1	0	0	0	9525	1000	35	5	2108	5	MEP1B	18	29797891	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25272	29797891	48279357	3732	8126										
KLHL14	57565	broad.mit.edu	37	chr18	30350502	30350502	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggttgaggccgtgcagcaggTtgtcgctgtggctggggtcg	20	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:30350502T>C	ENST00000359358.4	-	2	491	c.53A>G	c.(52-54)aAc>aGc	p.N18S	AC012123.1_ENST00000426194.1_Intron|KLHL14_ENST00000358095.4_Missense_Mutation_p.N18S	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	18						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GTGCAGCAGGTTGTCGCTGTG	0.632													38	59					0	0	1	0	0	C	30350502	T	C	30350502	3	2	48	1	0	0	0	0	1	0	0	0	8412	1725	60	4	1865	4	KLHL14	18	30350502	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	552611	30350502	47726746	3733	8127										
DTNA	1837	broad.mit.edu	37	chr18	32407596	32407596	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcatgaacgacaccctgttCtcccactctgttccctcctc	5	18	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:32407596C>A	ENST00000283365.9	+	12	1401	c.1050C>A	c.(1048-1050)ttC>ttA	p.F350L	DTNA_ENST00000556414.3_Missense_Mutation_p.F29L|DTNA_ENST00000591182.1_Missense_Mutation_p.F29L|DTNA_ENST00000598774.1_Missense_Mutation_p.F350L|DTNA_ENST00000315456.6_Missense_Mutation_p.F350L|DTNA_ENST00000601125.1_Missense_Mutation_p.F29L|DTNA_ENST00000597599.1_Missense_Mutation_p.F347L|DTNA_ENST00000399121.5_Missense_Mutation_p.F347L|DTNA_ENST00000348997.5_Missense_Mutation_p.F347L|DTNA_ENST00000599844.1_Missense_Mutation_p.F29L|DTNA_ENST00000444659.1_Missense_Mutation_p.F350L|DTNA_ENST00000597674.1_Missense_Mutation_p.F29L|DTNA_ENST00000269190.7_Missense_Mutation_p.F351L|DTNA_ENST00000269192.7_Missense_Mutation_p.F29L|DTNA_ENST00000595022.1_Missense_Mutation_p.F347L|DTNA_ENST00000399113.3_Missense_Mutation_p.F350L|DTNA_ENST00000399097.3_Missense_Mutation_p.F29L|DTNA_ENST00000598142.1_Missense_Mutation_p.F350L|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000554864.3_Missense_Mutation_p.F347L|DTNA_ENST00000269191.6_Missense_Mutation_p.F350L|DTNA_ENST00000598334.1_Missense_Mutation_p.F347L	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	350					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						ACACCCTGTTCTCCCACTCTG	0.403													29	48					2.61193e-14	3.39424e-14	1	1	0	A	32407596	C	A	32407596	3	1	48	1	0	0	0	0	1	0	0	0	4814	912	32	2	1088	2	DTNA	18	32407596	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2057094	32407596	45669652	3734	8128										
DTNA	1837	broad.mit.edu	37	chr18	32459636	32459636	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaatccatgcccgaaaaccTgggtacattcacagtggagc	9	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:32459636T>C	ENST00000283365.9	+	19	2214	c.1863T>C	c.(1861-1863)ccT>ccC	p.P621P	DTNA_ENST00000590831.2_Silent_p.P104P|DTNA_ENST00000556414.3_Silent_p.P330P|DTNA_ENST00000591182.1_Silent_p.P326P|DTNA_ENST00000601125.1_Silent_p.P300P|DTNA_ENST00000399121.5_Silent_p.P625P|DTNA_ENST00000444659.1_Silent_p.P678P|DTNA_ENST00000269190.7_Silent_p.P679P|DTNA_ENST00000269192.7_Silent_p.P387P|DTNA_ENST00000595022.1_Silent_p.P618P|DTNA_ENST00000399113.3_Silent_p.P678P|DTNA_ENST00000399097.3_Silent_p.P326P|DTNA_ENST00000598142.1_Silent_p.P621P|DTNA_ENST00000598334.1_Silent_p.P618P	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	678					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						CCCGAAAACCTGGGTACATTC	0.458													18	27					0	0	1	0	0	C	32459636	T	C	32459636	2	2	48	1	0	0	0	0	0	0	0	1	4814	1567	55	4		4	DTNA	18	32459636	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	52040	32459636	45617612	3735	8129										
ZNF396	252884	broad.mit.edu	37	chr18	32949295	32949295	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaccagtatgggttcgtcGatgctgaatcagaattgcgc	11	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:32949295G>A	ENST00000306346.1	-	4	1023	c.892C>T	c.(892-894)Cga>Tga	p.R298*	ZNF396_ENST00000589332.1_Nonsense_Mutation_p.R298*	NM_145756.2	NP_665699.1	Q96N95	ZN396_HUMAN	zinc finger protein 396	298					viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	7						TGGGTTCGTCGATGCTGAATC	0.438													4	38					0	0	1	0	0	A	32949295	G	A	32949295	4	1	48	1	0	0	0	0	0	1	0	0	17938	1066	37	1	117	1	ZNF396	18	32949295	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	489659	32949295	45127953	3736	8130										
FHOD3	80206	broad.mit.edu	37	chr18	34298177	34298177	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaacagcgccggtgcagccGaagacagagtctgattacat	12	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:34298177G>A	ENST00000257209.4	+	16	2513	c.2391G>A	c.(2389-2391)ccG>ccA	p.P797P	FHOD3_ENST00000590592.1_Silent_p.P972P|FHOD3_ENST00000359247.4_Silent_p.P780P|FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000445677.1_Silent_p.P759P	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	780					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CGGTGCAGCCGAAGACAGAGT	0.537													30	52					0	0	1	0	0	A	34298177	G	A	34298177	2	1	48	1	0	0	0	0	0	0	0	1	5915	1045	37	1		1	FHOD3	18	34298177	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1348882	34298177	43779071	3737	8131										
PIK3C3	5289	broad.mit.edu	37	chr18	39567792	39567792	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagctcaccaaagctcatcGacaaggacacatggtgaaag	10	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:39567792G>A	ENST00000262039.4	+	5	634	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	PIK3C3_ENST00000398870.3_Missense_Mutation_p.R120Q	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	183					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						AAAGCTCATCGACAAGGACAC	0.328										TSP Lung(28;0.18)			14	45					0	0	1	0	0	A	39567792	G	A	39567792	3	1	48	1	0	0	0	0	1	0	0	0	11959	1058	37	1	566	1	PIK3C3	18	39567792	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5269615	39567792	38509456	3738	8132										
PIK3C3	5289	broad.mit.edu	37	chr18	39617746	39617746	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atggagatgatttacgtcaaGatcaacttattcttcaaatc	6	7	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:39617746G>T	ENST00000262039.4	+	17	2016	c.1930G>T	c.(1930-1932)Gat>Tat	p.D644Y	PIK3C3_ENST00000587402.1_5'UTR|PIK3C3_ENST00000589056.1_5'UTR|PIK3C3_ENST00000398870.3_Missense_Mutation_p.D581Y|PIK3C3_ENST00000593098.1_Missense_Mutation_p.D129Y	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	644	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						TTTACGTCAAGATCAACTTAT	0.373										TSP Lung(28;0.18)			34	89					1.61788e-16	2.15322e-16	1	1	0	T	39617746	G	T	39617746	3	4	48	1	0	0	0	0	1	0	0	0	11959	942	33	2	1996	2	PIK3C3	18	39617746	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	49954	39617746	38459502	3739	8133										
SYT4	6860	broad.mit.edu	37	chr18	40851677	40851677	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatttcagaagcattcttacCtgaaagtccggacacatcag	7	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:40851677C>A	ENST00000255224.3	-	3	1338	c.970_splice	c.e3+1	p.D324_splice	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Splice_Site_p.D306_splice	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	324	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						GCATTCTTACCTGAAAGTCCG	0.393													16	35					1.15088e-07	1.32965e-07	1	1	0	A	40851677	C	A	40851677	5	1	48	1	0	0	0	0	0	0	1	0	15532	695	24	5	315	5	SYT4	18	40851677	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1233931	40851677	37225571	3740	8134										
KATNAL2	83473	broad.mit.edu	37	chr18	44579309	44579309	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactggggttacgacggtttGaagtttgtgacaacattgat	12	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:44579309G>T	ENST00000356157.7	+	3	199	c.181G>T	c.(181-183)Gaa>Taa	p.E61*	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_5'UTR			Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	61						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			central_nervous_system(2)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	27						ACGACGGTTTGAAGTTTGTGA	0.333													17	36					9.16793e-09	1.08598e-08	1	1	0	T	44579309	G	T	44579309	4	4	48	1	0	0	0	0	0	1	0	0	8029	1305	45	2		2	KATNAL2	18	44579309	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3727632	44579309	33497939	3741	8135										
DYM	54808	broad.mit.edu	37	chr18	46570519	46570519	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaccagacataggggataAaaaactcctcgggctgctcc	11	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:46570519A>C	ENST00000269445.6	-	17	2373	c.1916T>G	c.(1915-1917)tTt>tGt	p.F639C	RP11-15F12.1_ENST00000584252.1_RNA|DYM_ENST00000442713.2_Missense_Mutation_p.F449C	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	639						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						ATAGGGGATAAAAAACTCCTC	0.443													66	118					0	0	1	0	0	C	46570519	A	C	46570519	3	2	48	1	0	0	0	0	1	0	0	0	4866	14	1	4	97	4	DYM	18	46570519	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1991210	46570519	31506729	3742	8136										
MYO5B	4645	broad.mit.edu	37	chr18	47404165	47404165	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagggcatcctcagtgtctcCgatctcagatgtggagatgg	14	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:47404165C>T	ENST00000285039.7	-	25	3663	c.3364G>A	c.(3364-3366)Gga>Aga	p.G1122R	MYO5B_ENST00000324581.6_Missense_Mutation_p.G263R	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1122					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCAGTGTCTCCGATCTCAGAT	0.507													31	47					0	0	1	0	0	T	47404165	C	T	47404165	3	4	48	1	0	0	0	0	1	0	0	0	10126	661	23	1	2246	1	MYO5B	18	47404165	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	833646	47404165	30673083	3743	8137										
CXXC1	30827	broad.mit.edu	37	chr18	47809356	47809356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacgtacaagggggcacccGcatacctcgtcagctggcac	11	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:47809356G>A	ENST00000589940.1	-	14	1716	c.1655C>T	c.(1654-1656)gCg>gTg	p.A552V	CXXC1_ENST00000412036.2_Silent_p.C568C|CXXC1_ENST00000285106.6_Silent_p.C564C			Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	0					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						GGGGGCACCCGCATACCTCGT	0.592													23	46					0	0	1	0	0	A	47809356	G	A	47809356	3	1	48	1	0	0	0	0	1	0	0	0	4120	1079	38	1	286	1	CXXC1	18	47809356	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	405191	47809356	30267892	3744	8138										
MAPK4	5596	broad.mit.edu	37	chr18	48252489	48252489	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaggatgagatcgacgacatCgtgctgatggccgctaacca	13	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:48252489C>T	ENST00000400384.2	+	5	2047	c.1011C>T	c.(1009-1011)atC>atT	p.I337I	MAPK4_ENST00000592595.1_Intron|MAPK4_ENST00000540640.1_Silent_p.I126I	NM_002747.3	NP_002738.2	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	337					cell cycle		ATP binding|MAP kinase activity	p.I337I(1)		lung(4)|skin(3)|upper_aerodigestive_tract(1)	8		Colorectal(6;0.0297)		Colorectal(21;0.156)		TCGACGACATCGTGCTGATGG	0.602													34	64					0	0	1	0	0	T	48252489	C	T	48252489	2	4	48	1	0	0	0	0	0	0	0	1	9329	874	31	1		1	MAPK4	18	48252489	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	443133	48252489	29824759	3745	8139										
ME2	4200	broad.mit.edu	37	chr18	48446854	48446854	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaacacactcattcagttcGaagactttggaaatcataat	7	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:48446854G>A	ENST00000321341.5	+	8	1035	c.763G>A	c.(763-765)Gaa>Aaa	p.E255K	ME2_ENST00000382927.3_Missense_Mutation_p.E255K	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	255					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	CATTCAGTTCGAAGACTTTGG	0.338													8	23					0	0	1	0	0	A	48446854	G	A	48446854	3	1	48	1	0	0	0	0	1	0	0	0	9467	1059	37	1	789	1	ME2	18	48446854	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	194365	48446854	29630394	3746	8140										
DCC	1630	broad.mit.edu	37	chr18	49867163	49867163	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgttggctgaaatatggaGaatagtcttagatgtgtttg	14	2	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:49867163G>T	ENST00000442544.2	+	1	622	c.6G>T	c.(4-6)gaG>gaT	p.E2D		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	2					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAAATATGGAGAATAGTCTTA	0.542													37	91					5.71845e-15	7.50055e-15	1	1	0	T	49867163	G	T	49867163	3	4	48	1	0	0	0	0	1	0	0	0	4305	933	33	2	8	2	DCC	18	49867163	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1420309	49867163	28210085	3747	8141										
DCC	1630	broad.mit.edu	37	chr18	50278454	50278454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaagctttcacagcactgcGcttcctctcagaaccttctg	6	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:50278454G>A	ENST00000442544.2	+	2	738	c.122G>A	c.(121-123)cGc>cAc	p.R41H		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	41	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACAGCACTGCGCTTCCTCTCA	0.483													13	17					0	0	1	0	0	A	50278454	G	A	50278454	3	1	48	1	0	0	0	0	1	0	0	0	4305	1087	38	1	128	1	DCC	18	50278454	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	411291	50278454	27798794	3748	8142										
DCC	1630	broad.mit.edu	37	chr18	50432692	50432692	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaagcagaagtcagaattTtatcaggtattgcaatgctc	9	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:50432692T>G	ENST00000442544.2	+	3	1307	c.691T>G	c.(691-693)Tta>Gta	p.L231V	DCC_ENST00000412726.1_Missense_Mutation_p.L79V	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	231					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGTCAGAATTTTATCAGGTAT	0.383													30	41					0	0	1	0	0	G	50432692	T	G	50432692	3	3	48	1	0	0	0	0	1	0	0	0	4305	1838	64	4	701	4	DCC	18	50432692	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	154238	50432692	27644556	3749	8143										
DCC	1630	broad.mit.edu	37	chr18	50450145	50450145	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtagccattgaaggaaaaGatgctgtcctggaatgttgt	12	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:50450145G>T	ENST00000442544.2	+	4	1382	c.766G>T	c.(766-768)Gat>Tat	p.D256Y	DCC_ENST00000412726.1_Missense_Mutation_p.D104Y	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	256	Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGAAGGAAAAGATGCTGTCCT	0.423													18	21					0.0332995	0.0338902	1	1	0	T	50450145	G	T	50450145	3	4	48	1	0	0	0	0	1	0	0	0	4305	942	33	2	780	2	DCC	18	50450145	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17453	50450145	27627103	3750	8144										
DCC	1630	broad.mit.edu	37	chr18	50731697	50731697	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtccagtccaaggttacaGattgttctgcactgaggtgt	12	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:50731697G>T	ENST00000442544.2	+	10	2301	c.1685G>T	c.(1684-1686)aGa>aTa	p.R562I	DCC_ENST00000581580.1_Missense_Mutation_p.R217I|DCC_ENST00000412726.1_Missense_Mutation_p.R410I	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	562	Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAAGGTTACAGATTGTTCTGC	0.488													71	111					3.58576e-35	5.15276e-35	1	1	0	T	50731697	G	T	50731697	3	4	48	1	0	0	0	0	1	0	0	0	4305	942	33	2	1723	2	DCC	18	50731697	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	281552	50731697	27345551	3751	8145										
DCC	1630	broad.mit.edu	37	chr18	50923743	50923743	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaacacaatgtatgaattCtcggtcatggtaacaaaaaa	6	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:50923743C>A	ENST00000442544.2	+	18	3370	c.2754C>A	c.(2752-2754)ttC>ttA	p.F918L	DCC_ENST00000581580.1_Missense_Mutation_p.F553L|DCC_ENST00000412726.1_Missense_Mutation_p.F746L	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	918	Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.F918L(1)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGTATGAATTCTCGGTCATGG	0.403													15	35					7.93312e-07	8.98086e-07	1	1	0	A	50923743	C	A	50923743	3	1	48	1	0	0	0	0	1	0	0	0	4305	912	32	2	2824	2	DCC	18	50923743	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	192046	50923743	27153505	3752	8146										
DCC	1630	broad.mit.edu	37	chr18	51053053	51053053	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctggaaaagcaagatcccCtttgcttcctgtgtctgtgc	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:51053053C>A	ENST00000442544.2	+	28	4794	c.4178C>A	c.(4177-4179)cCt>cAt	p.P1393H	DCC_ENST00000581580.1_Missense_Mutation_p.P1026H|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1393					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCAAGATCCCCTTTGCTTCCT	0.468													34	53					7.11191e-15	9.30872e-15	1	1	0	A	51053053	C	A	51053053	3	1	48	1	0	0	0	0	1	0	0	0	4305	681	24	5	4288	5	DCC	18	51053053	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	129310	51053053	27024195	3753	8147										
POLI	11201	broad.mit.edu	37	chr18	51810358	51810358	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagctaaaaataagattgaaGaactacttgctagtctttta	6	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:51810358G>T	ENST00000579534.1	+	7	1185	c.1042G>T	c.(1042-1044)Gaa>Taa	p.E348*	POLI_ENST00000406285.3_Nonsense_Mutation_p.E269*|POLI_ENST00000579434.1_Nonsense_Mutation_p.E245*|POLI_ENST00000217800.5_Nonsense_Mutation_p.E222*	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	348					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		TAAGATTGAAGAACTACTTGC	0.299								DNA polymerases (catalytic subunits)					3	16					0.004672	0.00483628	1	1	0	T	51810358	G	T	51810358	4	4	48	1	0	0	0	0	0	1	0	0	12250	943	33	2	1068	2	POLI	18	51810358	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	757305	51810358	26266890	3754	8148										
C18orf54	162681	broad.mit.edu	37	chr18	51898953	51898953	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataagaccacagatccaaaaGaagagattaaacaagtaagc	7	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:51898953G>T	ENST00000300091.5	+	6	1293	c.961G>T	c.(961-963)Gaa>Taa	p.E321*	C18orf54_ENST00000382911.4_Nonsense_Mutation_p.E482*|C18orf54_ENST00000582188.1_3'UTR|C18orf54_ENST00000578138.1_Nonsense_Mutation_p.E100*	NM_173529.4	NP_775800.3	Q8IYD9	CR054_HUMAN	chromosome 18 open reading frame 54	321						extracellular region				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		AGATCCAAAAGAAGAGATTAA	0.303													17	36					3.52763e-06	3.92945e-06	1	1	0	T	51898953	G	T	51898953	4	4	48	1	0	0	0	0	0	1	0	0	1915	943	33	2	979	2	C18orf54	18	51898953	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	88595	51898953	26178295	3755	8149										
ST8SIA3	51046	broad.mit.edu	37	chr18	55021708	55021708	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcacccaggaactccaagaGaaaccttctaagtggaaatt	7	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:55021708G>T	ENST00000324000.3	+	2	2289	c.255G>T	c.(253-255)gaG>gaT	p.E85D		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	85					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		AACTCCAAGAGAAACCTTCTA	0.433													45	69					1.15505e-17	1.55342e-17	1	1	0	T	55021708	G	T	55021708	3	4	48	1	0	0	0	0	1	0	0	0	15288	933	33	2	261	2	ST8SIA3	18	55021708	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3122755	55021708	23055540	3756	8150										
ATP8B1	5205	broad.mit.edu	37	chr18	55338749	55338749	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggattcattcgatgtaacCgttcataaataacagtgtca	7	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:55338749C>T	ENST00000536015.1	-	17	2002	c.1883G>A	c.(1882-1884)cGg>cAg	p.R628Q	ATP8B1_ENST00000283684.4_Missense_Mutation_p.R628Q|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	628			R -> W (in BRIC1).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				TCGATGTAACCGTTCATAAAT	0.373													12	37					0	0	1	0	0	T	55338749	C	T	55338749	3	4	48	1	0	0	0	0	1	0	0	0	1192	652	23	1	1920	1	ATP8B1	18	55338749	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	317041	55338749	22738499	3757	8151										
CCBE1	147372	broad.mit.edu	37	chr18	57363940	57363940	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgctctctgagcagatttCtctatgaaaaagtgcagagg	10	7	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:57363940C>A	ENST00000439986.4	-	2	170	c.131_splice	c.e2-1	p.E45_splice	RP11-2N1.2_ENST00000588946.1_RNA	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	45					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GAGCAGATTTCTCTATGAAAA	0.587											OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	51					3.83957e-06	4.27438e-06	1	1	0	A	57363940	C	A	57363940	5	1	48	1	0	0	0	0	0	0	1	0	2749	927	32	2	1127	2	CCBE1	18	57363940	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2025191	57363940	20713308	3758	8152										
PMAIP1	5366	broad.mit.edu	37	chr18	57569889	57569889	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttctcagagctggaagtCgagtgtgctactcaactcag	10	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:57569889C>T	ENST00000269518.9	+	3	382	c.220C>T	c.(220-222)Cga>Tga	p.R74*	PMAIP1_ENST00000316660.6_Silent_p.V23V			Q13794	APR_HUMAN	phorbol-12-myristate-13-acetate-induced protein 1	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to glucose starvation|cellular response to hypoxia|negative regulation of mitochondrial membrane potential|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of glucose metabolic process|positive regulation of protein oligomerization|positive regulation of release of cytochrome c from mitochondria|proteasomal protein catabolic process|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability|response to dsRNA|signal transduction by p53 class mediator resulting in induction of apoptosis|T cell homeostasis|virus-infected cell apoptosis	cytosol|mitochondrial outer membrane|nucleus	protein binding			breast(1)	1		Colorectal(73;0.0946)				AGCTGGAAGTCGAGTGTGCTA	0.433													24	38					0	0	1	0	0	T	57569889	C	T	57569889	4	4	48	1	0	0	0	0	0	1	0	0	12177	871	31	1	75	1	PMAIP1	18	57569889	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	205949	57569889	20507359	3759	8153										
PMAIP1	5366	broad.mit.edu	37	chr18	57569963	57569963	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttctgaatctgatatccaAactcttctgctcaggaacct	5	12	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:57569963A>C	ENST00000316660.6	+	2	373	c.143A>C	c.(142-144)aAa>aCa	p.K48T	PMAIP1_ENST00000269518.9_Missense_Mutation_p.Q98H	NM_021127.2	NP_066950.1	Q13794	APR_HUMAN	phorbol-12-myristate-13-acetate-induced protein 1	48	Required for mitochondrial location.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to glucose starvation|cellular response to hypoxia|negative regulation of mitochondrial membrane potential|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of glucose metabolic process|positive regulation of protein oligomerization|positive regulation of release of cytochrome c from mitochondria|proteasomal protein catabolic process|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability|response to dsRNA|signal transduction by p53 class mediator resulting in induction of apoptosis|T cell homeostasis|virus-infected cell apoptosis	cytosol|mitochondrial outer membrane|nucleus	protein binding			breast(1)	1		Colorectal(73;0.0946)				CTGATATCCAAACTCTTCTGC	0.438													18	33					0	0	1	0	0	C	57569963	A	C	57569963	3	2	48	1	0	0	0	0	1	0	0	0	12177	14	1	4	149	4	PMAIP1	18	57569963	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	74	57569963	20507285	3760	8154										
TNFRSF11A	8792	broad.mit.edu	37	chr18	60025530	60025530	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttgccttgcaggctacttCtctgatgccttttcctccac	6	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:60025530C>A	ENST00000586569.1	+	5	515	c.477C>A	c.(475-477)ttC>ttA	p.F159L	TNFRSF11A_ENST00000269485.7_Missense_Mutation_p.F159L	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	159					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				CAGGCTACTTCTCTGATGCCT	0.418													39	50					1.59932e-28	2.27211e-28	1	1	0	A	60025530	C	A	60025530	3	1	48	1	0	0	0	0	1	0	0	0	16343	912	32	2	495	2	TNFRSF11A	18	60025530	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2455567	60025530	18051718	3761	8155										
PHLPP1	23239	broad.mit.edu	37	chr18	60646231	60646231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacatccactgcagccgggCcaaggagaaggagaaacagc	14	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:60646231C>T	ENST00000400316.4	+	17	4966	c.3185C>T	c.(3184-3186)gCc>gTc	p.A1062V	PHLPP1_ENST00000262719.5_Missense_Mutation_p.A1574V	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1574				L -> F (in Ref. 4; AAH47653).	apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						TGCAGCCGGGCCAAGGAGAAG	0.622													10	17					0	0	1	0	0	T	60646231	C	T	60646231	3	4	48	1	0	0	0	0	1	0	0	0	11901	739	26	3	4787	3	PHLPP1	18	60646231	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	620701	60646231	17431017	3762	8156										
KDSR	2531	broad.mit.edu	37	chr18	61002592	61002592	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaactgttgaaatttccttgCtaaaagagaagaaaaagaag	9	4	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:61002592C>T	ENST00000406396.3	-	9	1169		c.e9-1		KDSR_ENST00000326575.5_Splice_Site|KDSR_ENST00000589592.1_Splice_Site	NM_002035.2	NP_002026.1	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase						3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			endometrium(2)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	9						AATTTCCTTGCTAAAAGAGAA	0.468													20	29					0	0	1	0	0	T	61002592	C	T	61002592	5	4	48	1	0	0	0	0	0	0	1	0	8182	811	28	3	229	3	KDSR	18	61002592	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	356361	61002592	17074656	3763	8157										
SERPINB5	5268	broad.mit.edu	37	chr18	61166405	61166405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaggccacgttctgtatggGaaacattgacagtatcaatt	11	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:61166405G>A	ENST00000382771.4	+	6	912	c.620G>A	c.(619-621)gGa>gAa	p.G207E	SERPINB5_ENST00000464346.1_3'UTR	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	207					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						TTCTGTATGGGAAACATTGAC	0.408													31	43					0	0	1	0	0	A	61166405	G	A	61166405	3	1	48	1	0	0	0	0	1	0	0	0	14157	1174	41	3	638	3	SERPINB5	18	61166405	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	163813	61166405	16910843	3764	8158										
SERPINB3	6317	broad.mit.edu	37	chr18	61324590	61324590	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaatagattgcgttcacaaGaaccaatgtggtattgctgc	10	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:61324590G>T	ENST00000283752.5	-	6	669	c.526C>A	c.(526-528)Ctt>Att	p.L176I	SERPINB3_ENST00000332821.8_Missense_Mutation_p.L176I|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	176					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						GCGTTCACAAGAACCAATGTG	0.323													4	65					1	1	1	1	0	T	61324590	G	T	61324590	3	4	48	1	0	0	0	0	1	0	0	0	14155	942	33	2	658	2	SERPINB3	18	61324590	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	158185	61324590	16752658	3765	8159										
CDH19	28513	broad.mit.edu	37	chr18	64212074	64212074	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctcctatgtcattatcaTatgccatgattgttcctata	4	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:64212074T>G	ENST00000262150.2	-	6	1134	c.842A>C	c.(841-843)tAt>tCt	p.Y281S	CDH19_ENST00000540086.1_Missense_Mutation_p.Y281S	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	281	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				GTCATTATCATATGCCATGAT	0.358													8	15					0	0	1	0	0	G	64212074	T	G	64212074	3	3	48	1	0	0	0	0	1	0	0	0	3126	1406	49	4	1504	4	CDH19	18	64212074	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2887484	64212074	13865174	3766	8160										
DSEL	92126	broad.mit.edu	37	chr18	65178668	65178668	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccctctattttaaacaattTtgctaaatgctctggtacat	4	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:65178668T>G	ENST00000310045.7	-	2	4681	c.3208A>C	c.(3208-3210)Aaa>Caa	p.K1070Q	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1060						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TTAAACAATTTTGCTAAATGC	0.333													12	35					0	0	1	0	0	G	65178668	T	G	65178668	3	3	48	1	0	0	0	0	1	0	0	0	4801	1850	64	4	464	4	DSEL	18	65178668	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	966594	65178668	12898580	3767	8161										
DSEL	92126	broad.mit.edu	37	chr18	65178964	65178964	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaaagactctctccttttaAattttctttttttgtcctta	3	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:65178964A>C	ENST00000310045.7	-	2	4385	c.2912T>G	c.(2911-2913)tTt>tGt	p.F971C	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	961						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TCTCCTTTTAAATTTTCTTTT	0.378													14	34					0	0	1	0	0	C	65178964	A	C	65178964	3	2	48	1	0	0	0	0	1	0	0	0	4801	14	1	4	760	4	DSEL	18	65178964	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	296	65178964	12898284	3768	8162										
DSEL	92126	broad.mit.edu	37	chr18	65180565	65180565	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacacaaaggtgttggtctgTgtgtttggcaacccagcccc	12	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:65180565T>C	ENST00000310045.7	-	2	2784	c.1311A>G	c.(1309-1311)acA>acG	p.T437T	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	427						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TGTTGGTCTGTGTGTTTGGCA	0.483													14	33					0	0	1	0	0	C	65180565	T	C	65180565	2	2	48	1	0	0	0	0	0	0	0	1	4801	1683	59	4		4	DSEL	18	65180565	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1601	65180565	12896683	3769	8163										
TMX3	54495	broad.mit.edu	37	chr18	66365258	66365258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgttgacttggaagtggccGaattagagccctgttgcaca	12	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:66365258G>A	ENST00000299608.2	-	7	719	c.403C>T	c.(403-405)Cgg>Tgg	p.R135W	TMX3_ENST00000443099.2_Missense_Mutation_p.R108W|TMX3_ENST00000562706.1_Missense_Mutation_p.R135W	NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	135					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						GGAAGTGGCCGAATTAGAGCC	0.318													12	21					0	0	1	0	0	A	66365258	G	A	66365258	3	1	48	1	0	0	0	0	1	0	0	0	16327	1057	37	1	1001	1	TMX3	18	66365258	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1184693	66365258	11711990	3770	8164										
CCDC102B	79839	broad.mit.edu	37	chr18	66505962	66505962	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaacaaggtgtggttattgAttctctaaaattaagtgagg	12	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:66505962A>C	ENST00000360242.5	+	3	743	c.626A>C	c.(625-627)gAt>gCt	p.D209A	CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000319445.6_Missense_Mutation_p.D209A|CCDC102B_ENST00000584156.1_Missense_Mutation_p.D209A|CCDC102B_ENST00000358653.5_Missense_Mutation_p.D209A	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	209										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GTGGTTATTGATTCTCTAAAA	0.343													9	26					0	0	1	0	0	C	66505962	A	C	66505962	3	2	48	1	0	0	0	0	1	0	0	0	2755	333	12	4	632	4	CCDC102B	18	66505962	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	140704	66505962	11571286	3771	8165										
CCDC102B	79839	broad.mit.edu	37	chr18	66721328	66721328	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctggatgaagagaaagaaaGaaatgaaaacttagagactg	11	3	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:66721328G>T	ENST00000360242.5	+	8	1613	c.1496G>T	c.(1495-1497)aGa>aTa	p.R499I	CCDC102B_ENST00000319445.6_Missense_Mutation_p.R499I	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	499								p.R499K(1)		breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GAGAAAGAAAGAAATGAAAAC	0.368													21	42					3.5997e-14	4.67138e-14	1	1	0	T	66721328	G	T	66721328	3	4	48	1	0	0	0	0	1	0	0	0	2755	942	33	2	1522	2	CCDC102B	18	66721328	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	215366	66721328	11355920	3772	8166										
NETO1	81832	broad.mit.edu	37	chr18	70526222	70526222	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccaaaaggtccatctcgaActtcaatatgatcaaatttg	6	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:70526222A>G	ENST00000327305.6	-	4	965	c.308T>C	c.(307-309)gTt>gCt	p.V103A	NETO1_ENST00000299430.2_Missense_Mutation_p.V102A|NETO1_ENST00000583169.1_Missense_Mutation_p.V103A|NETO1_ENST00000580049.1_5'UTR|NETO1_ENST00000397929.1_Missense_Mutation_p.V102A	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	103	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TCCATCTCGAACTTCAATATG	0.378													16	20					0	0	1	0	0	G	70526222	A	G	70526222	3	3	48	1	0	0	0	0	1	0	0	0	10385	43	2	4	1330	4	NETO1	18	70526222	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3804894	70526222	7551026	3773	8167										
CNDP1	84735	broad.mit.edu	37	chr18	72247405	72247405	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtgttctccaaaagaaatAgttccaacaagatggttgtt	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:72247405A>C	ENST00000582365.1	+	9	1144	c.1078A>C	c.(1078-1080)Agt>Cgt	p.S360R	CNDP1_ENST00000358821.3_Missense_Mutation_p.S403R			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	403					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity	p.S403G(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		CAAAAGAAATAGTTCCAACAA	0.388													11	15					0	0	1	0	0	C	72247405	A	C	72247405	3	2	48	1	0	0	0	0	1	0	0	0	3616	420	15	4	1245	4	CNDP1	18	72247405	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1721183	72247405	5829843	3774	8168										
ZNF407	55628	broad.mit.edu	37	chr18	72344194	72344194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atacccttcaggcagcacacGgtaacagtgtaacctcgagg	10	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:72344194G>A	ENST00000299687.5	+	1	1219	c.1219G>A	c.(1219-1221)Ggt>Agt	p.G407S	ZNF407_ENST00000582337.1_Missense_Mutation_p.G407S|ZNF407_ENST00000577538.1_Missense_Mutation_p.G407S|ZNF407_ENST00000309902.6_Missense_Mutation_p.G407S	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGCAGCACACGGTAACAGTGT	0.468													16	39					0	0	1	0	0	A	72344194	G	A	72344194	3	1	48	1	0	0	0	0	1	0	0	0	17943	1116	39	1	1221	1	ZNF407	18	72344194	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	96789	72344194	5733054	3775	8169										
GALR1	2587	broad.mit.edu	37	chr18	74980781	74980781	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaagtgtcacattcgcaaaGattcacacctgagtgatact	7	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:74980781G>T	ENST00000299727.3	+	3	973	c.973G>T	c.(973-975)Gat>Tat	p.D325Y		NM_001480.3	NP_001471.2	P47211	GALR1_HUMAN	galanin receptor 1	325					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CATTCGCAAAGATTCACACCT	0.388													12	100					9.05144e-12	1.13153e-11	1	1	0	T	74980781	G	T	74980781	3	4	48	1	0	0	0	0	1	0	0	0	6266	942	33	2	983	2	GALR1	18	74980781	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2636587	74980781	3096467	3776	8170										
SALL3	27164	broad.mit.edu	37	chr18	76754412	76754412	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacgagaactccatggaggaCgacgctgagctgaaggacgc	15	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:76754412C>T	ENST00000536229.3	+	1	2731	c.2022C>T	c.(2020-2022)gaC>gaT	p.D674D	SALL3_ENST00000537592.2_Silent_p.D807D|SALL3_ENST00000575389.2_Silent_p.D807D			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	807					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCATGGAGGACGACGCTGAGC	0.652													15	25					0	0	1	0	0	T	76754412	C	T	76754412	2	4	48	1	0	0	0	0	0	0	0	1	13863	535	19	1		1	SALL3	18	76754412	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1773631	76754412	1322836	3777	8171										
ATP9B	374868	broad.mit.edu	37	chr18	76953202	76953202	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaccttttttctatcagtgCttatgtttatgctcagaaac	7	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr18:76953202C>T	ENST00000426216.2	+	9	910	c.893C>T	c.(892-894)gCt>gTt	p.A298V	ATP9B_ENST00000307671.7_Missense_Mutation_p.A298V	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	298					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TCTATCAGTGCTTATGTTTAT	0.318													6	45					0	0	1	0	0	T	76953202	C	T	76953202	3	4	48	1	0	0	0	0	1	0	0	0	1197	797	28	3	927	3	ATP9B	18	76953202	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	198790	76953202	1124046	3778	8172										
ABCA7	10347	broad.mit.edu	37	chr19	1042699	1042699	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccagagcgctggacccctAgtgagtgttcaaaatcattg	12	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:1042699A>G	ENST00000435683.2	+	1	39	c.39A>G	c.(37-39)ctA>ctG	p.L13L	ABCA7_ENST00000263094.6_Intron|ABCA7_ENST00000433129.1_Intron			Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	0					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGACCCCTAGTGAGTGTTC	0.552													9	49					0	0	1	0	0	G	1042699	A	G	1042699	2	3	48	1	0	0	0	0	0	0	0	1	37	435	15	4		4	ABCA7	19	1042699	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08		1042699	58086284	3779	8173										
SBNO2	22904	broad.mit.edu	37	chr19	1147372	1147372	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacgggggcatagctggtgTctgggcagggctggctgccg	19	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:1147372T>C	ENST00000361757.3	-	4	452	c.215A>G	c.(214-216)gAc>gGc	p.D72G	SBNO2_ENST00000587024.1_Missense_Mutation_p.D72G	NM_014963.2	NP_055778.2	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 (Drosophila)	72					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent					NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATAGCTGGTGTCTGGGCAGGG	0.687													26	31					0	0	1	0	0	C	1147372	T	C	1147372	3	2	48	1	0	0	0	0	1	0	0	0	13915	1667	58	4	4113	4	SBNO2	19	1147372	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	104673	1147372	57981611	3780	8174										
APC2	10297	broad.mit.edu	37	chr19	1453536	1453536	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcagcccagtacacggctcCgggccctccaaggacagctt	12	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:1453536C>T	ENST00000535453.1	+	3	2052	c.339C>T	c.(337-339)tcC>tcT	p.S113S	APC2_ENST00000238483.4_Silent_p.S113S|APC2_ENST00000233607.2_Silent_p.S113S			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	113					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACACGGCTCCGGGCCCTCCA	0.692													13	36					0	0	1	0	0	T	1453536	C	T	1453536	2	4	48	1	0	0	0	0	0	0	0	1	760	639	23	1		1	APC2	19	1453536	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	306164	1453536	57675447	3781	8175										
ATP8B3	148229	broad.mit.edu	37	chr19	1787174	1787174	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaagagccaggaaccatccTtcatacaggggctgagccgg	12	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:1787174T>G	ENST00000539485.1	-	25	3344	c.3111A>C	c.(3109-3111)gaA>gaC	p.E1037D	ATP8B3_ENST00000525591.1_Missense_Mutation_p.E990D|ATP8B3_ENST00000310127.6_Missense_Mutation_p.E1027D			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1027					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAACCATCCTTCATACAGGG	0.597													8	14					0	0	1	0	0	G	1787174	T	G	1787174	3	3	48	1	0	0	0	0	1	0	0	0	1194	1606	56	4	841	4	ATP8B3	19	1787174	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	333638	1787174	57341809	3782	8176										
REXO1	57455	broad.mit.edu	37	chr19	1816537	1816537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgcagcgtgacacttgtgtCggcaaggtcagcctccgtca	12	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:1816537C>T	ENST00000170168.4	-	14	3443	c.3349G>A	c.(3349-3351)Gac>Aac	p.D1117N		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	1117	Exonuclease.					nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACTTGTGTCGGCAAGGTCA	0.662													23	47					0	0	1	0	0	T	1816537	C	T	1816537	3	4	48	1	0	0	0	0	1	0	0	0	13292	884	31	1	328	1	REXO1	19	1816537	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29363	1816537	57312446	3783	8177										
SCAMP4	113178	broad.mit.edu	37	chr19	1918133	1918133	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctcttcgcagtttactgCgccaccctcggcgtcaacct	7	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:1918133C>T	ENST00000316097.8	+	4	411	c.144C>T	c.(142-144)tgC>tgT	p.C48C	SCAMP4_ENST00000409472.1_Silent_p.C48C|SCAMP4_ENST00000414057.2_3'UTR	NM_079834.2	NP_524558.1	Q969E2	SCAM4_HUMAN	secretory carrier membrane protein 4	48					protein transport	integral to membrane							Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGTTTACTGCGCCACCCTCG	0.662													14	32					0	0	1	0	0	T	1918133	C	T	1918133	2	4	48	1	0	0	0	0	0	0	0	1	13925	776	27	1		1	SCAMP4	19	1918133	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	101596	1918133	57210850	3784	8178										
AP3D1	8943	broad.mit.edu	37	chr19	2151286	2151286	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggaccaagtcctgcagattCttgtcgaacatgcggtcgat	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:2151286C>A	ENST00000355272.6	-	1	254	c.48G>T	c.(46-48)aaG>aaT	p.K16N	AP3D1_ENST00000350812.6_Missense_Mutation_p.K16N|AP3D1_ENST00000356926.4_Missense_Mutation_p.K16N|AP3D1_ENST00000345016.5_Missense_Mutation_p.K16N	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	16					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCAGATTCTTGTCGAACA	0.692													10	26					6.42651e-13	8.16824e-13	1	1	0	A	2151286	C	A	2151286	3	1	48	1	0	0	0	0	1	0	0	0	742	912	32	2	3691	2	AP3D1	19	2151286	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	233153	2151286	56977697	3785	8179										
ATCAY	85300	broad.mit.edu	37	chr19	3905590	3905590	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atattaacgtggatgacatcGagacccccgatgagaccgac	10	11	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:3905590G>A	ENST00000450849.2	+	4	762	c.295G>A	c.(295-297)Gag>Aag	p.E99K	ATCAY_ENST00000301260.6_Missense_Mutation_p.E99K|ATCAY_ENST00000398448.3_Missense_Mutation_p.E105K|ATCAY_ENST00000600960.1_Missense_Mutation_p.E99K	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	99					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GGATGACATCGAGACCCCCGA	0.557													47	55					0	0	1	0	0	A	3905590	G	A	3905590	3	1	48	1	0	0	0	0	1	0	0	0	1076	1059	37	1	305	1	ATCAY	19	3905590	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1754304	3905590	55223393	3786	8180										
ZBTB7A	51341	broad.mit.edu	37	chr19	4054879	4054879	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcgcacacgtggctcacggCggggatctccagcaggcggg	18	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:4054879C>T	ENST00000322357.4	-	2	630	c.352G>A	c.(352-354)Gcc>Acc	p.A118T	ZBTB7A_ENST00000601588.1_Missense_Mutation_p.A118T	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	118					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCTCACGGCGGGGATCTCC	0.682													12	9					0	0	1	0	0	T	4054879	C	T	4054879	3	4	48	1	0	0	0	0	1	0	0	0	17611	768	27	1	1410	1	ZBTB7A	19	4054879	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	149289	4054879	55074104	3787	8181										
TMIGD2	126259	broad.mit.edu	37	chr19	4294612	4294612	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagctgcggcggccccagaAccaggcaccccacacgatcg	12	18	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:4294612A>G	ENST00000301272.2	-	4	559	c.514T>C	c.(514-516)Ttc>Ctc	p.F172L	TMIGD2_ENST00000600349.1_Intron|TMIGD2_ENST00000600114.1_Missense_Mutation_p.F52L|TMIGD2_ENST00000595645.1_Missense_Mutation_p.F172L	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	172						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCCCCAGAACCAGGCACCC	0.617													117	229					0	0	1	0	0	G	4294612	A	G	4294612	3	3	48	1	0	0	0	0	1	0	0	0	16290	43	2	4	342	4	TMIGD2	19	4294612	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	239733	4294612	54834371	3788	8182										
FUT5	2527	broad.mit.edu	37	chr19	5867215	5867215	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcgtgaagatgtcggagtcGctgcggtaggacatggtgag	19	6	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:5867215G>A	ENST00000252675.5	-	5	1084	c.522C>T	c.(520-522)agC>agT	p.S174S	FUT5_ENST00000588525.1_Silent_p.S174S			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	174					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						TGTCGGAGTCGCTGCGGTAGG	0.652													24	43					0	0	1	0	0	A	5867215	G	A	5867215	2	1	48	1	0	0	0	0	0	0	0	1	6141	1078	38	1		1	FUT5	19	5867215	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1572603	5867215	53261768	3789	8183										
NDUFA11	126328	broad.mit.edu	37	chr19	5894850	5894850	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acacgcaggcggcggcgccaAtcccgtagttgtgcgctgtg	15	13	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:5894850A>C	ENST00000308961.4	-	4	376	c.329T>G	c.(328-330)aTt>aGt	p.I110S	NDUFA11_ENST00000418389.2_Intron|AC024592.12_ENST00000586349.1_Intron|FUT5_ENST00000252675.5_Intron|NDUFA11_ENST00000592634.1_3'UTR	NM_175614.4	NP_783313.1	Q86Y39	NDUAB_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa	110					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I	protein transporter activity			central_nervous_system(1)|lung(1)	2					NADH(DB00157)	GGCGGCGCCAATCCCGTAGTT	0.682													4	10					0	0	1	0	0	C	5894850	A	C	5894850	3	2	48	1	0	0	0	0	1	0	0	0	10307	101	4	4	100	4	NDUFA11	19	5894850	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	27635	5894850	53234133	3790	8184										
MLLT1	4298	broad.mit.edu	37	chr19	6262312	6262312	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctctactttgtaggggggcTccttgcacactaaaaagaaa	9	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:6262312T>C	ENST00000252674.7	-	3	366	c.203A>G	c.(202-204)gAg>gGg	p.E68G		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	68	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						GTAGGGGGGCTCCTTGCACAC	0.567			T	MLL	AL								16	37					0	0	1	0	0	C	6262312	T	C	6262312	3	2	48	1	0	0	0	0	1	0	0	0	9672	1551	54	4	1516	4	MLLT1	19	6262312	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	367462	6262312	52866671	3791	8185										
KHSRP	8570	broad.mit.edu	37	chr19	6416504	6416504	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcccgccccaacccacctcGatcttttcctcgataagctg	6	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:6416504G>A	ENST00000398148.3	-	14	1577	c.1485C>T	c.(1483-1485)atC>atT	p.I495I	MIR3940_ENST00000579148.1_RNA	NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	495	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding	p.I495I(1)		breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						AACCCACCTCGATCTTTTCCT	0.587													8	17					0	0	1	0	0	A	6416504	G	A	6416504	2	1	48	1	0	0	0	0	0	0	0	1	8192	1048	37	1		1	KHSRP	19	6416504	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	154192	6416504	52712479	3792	8186										
EMR1	2015	broad.mit.edu	37	chr19	6906479	6906479	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaaggaagatgtgatacccGataataagcagatccagcaa	10	7	0	3	rs151096072		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:6906479G>A	ENST00000312053.4	+	9	1022	c.985G>A	c.(985-987)Gat>Aat	p.D329N	EMR1_ENST00000450315.3_Missense_Mutation_p.D152N|EMR1_ENST00000381404.4_Missense_Mutation_p.D277N|EMR1_ENST00000381407.5_Missense_Mutation_p.D188N|EMR1_ENST00000250572.8_Missense_Mutation_p.D329N	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	329	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.D329Y(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TGTGATACCCGATAATAAGCA	0.393													29	43					0	0	1	0	0	A	6906479	G	A	6906479	3	1	48	1	0	0	0	0	1	0	0	0	5132	1058	37	1	1019	1	EMR1	19	6906479	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	489975	6906479	52222504	3793	8187										
INSR	0	broad.mit.edu	37	chr19	7125368	7125368	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgctctcggagactggctgActcgttgaccgtcttcaccg	11	15	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:7125368A>G	ENST00000341500.5	-	16	3187	c.3148T>C	c.(3148-3150)Tca>Cca	p.S1050P	INSR_ENST00000302850.5_Missense_Mutation_p.S1062P	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1062	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGACTGGCTGACTCGTTGACC	0.612													29	67					0	0	1	0	0	G	7125368	A	G	7125368	3	3	48	1	0	0	0	0	1	0	0	0	7816	275	10	4	988	4	INSR	19	7125368	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	218889	7125368	52003615	3794	8188										
ARHGEF18	23370	broad.mit.edu	37	chr19	7523545	7523545	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaagaggacaggaacgccTggatggcccacatccaaagg	12	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:7523545T>C	ENST00000359920.6	+	9	2018	c.1765T>C	c.(1765-1767)Tgg>Cgg	p.W589R	CTD-2207O23.3_ENST00000593531.1_Silent_p.P546P|ARHGEF18_ENST00000319670.9_Missense_Mutation_p.W431R	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	589	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				CAGGAACGCCTGGATGGCCCA	0.582													10	48					0	0	1	0	0	C	7523545	T	C	7523545	3	2	48	1	0	0	0	0	1	0	0	0	898	1580	55	4	1799	4	ARHGEF18	19	7523545	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	398177	7523545	51605438	3795	8189										
SNAPC2	6618	broad.mit.edu	37	chr19	7987561	7987561	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgagcacagcgaactgaaatCgccttggcaagcagctggga	13	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:7987561C>T	ENST00000221573.6	+	5	968	c.917C>T	c.(916-918)tCg>tTg	p.S306L	SNAPC2_ENST00000597584.1_Missense_Mutation_p.S69L	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	306					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GAACTGAAATCGCCTTGGCAA	0.682													45	79					0	0	1	0	0	T	7987561	C	T	7987561	3	4	48	1	0	0	0	0	1	0	0	0	14888	893	31	1	935	1	SNAPC2	19	7987561	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	464016	7987561	51141422	3796	8190										
FBN3	84467	broad.mit.edu	37	chr19	8191614	8191614	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacctagacagaaggtaccaGaggggtccagccggctgcca	13	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:8191614G>T	ENST00000600128.1	-	19	2813	c.2399C>A	c.(2398-2400)tCt>tAt	p.S800Y	FBN3_ENST00000601739.1_Missense_Mutation_p.S800Y|FBN3_ENST00000270509.2_Missense_Mutation_p.S800Y			Q75N90	FBN3_HUMAN	fibrillin 3	800	EGF-like 10; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GAAGGTACCAGAGGGGTCCAG	0.667													21	39					8.34094e-07	9.42356e-07	1	1	0	T	8191614	G	T	8191614	3	4	48	1	0	0	0	0	1	0	0	0	5736	942	33	2	6214	2	FBN3	19	8191614	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	204053	8191614	50937369	3797	8191										
MYO1F	4542	broad.mit.edu	37	chr19	8612994	8612994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagttgatgcaaaactgctCgaagccatttttctgcagaa	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:8612994C>T	ENST00000338257.8	-	12	1462	c.1195G>A	c.(1195-1197)Gag>Aag	p.E399K		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	399	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CAAAACTGCTCGAAGCCATTT	0.547													94	117					0	0	1	0	0	T	8612994	C	T	8612994	3	4	48	1	0	0	0	0	1	0	0	0	10120	893	31	1	2169	1	MYO1F	19	8612994	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	421380	8612994	50515989	3798	8192										
ZNF558	148156	broad.mit.edu	37	chr19	8922567	8922567	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctccccattatggattCtcttatgaatagtaaggtaa	7	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:8922567C>A	ENST00000601372.1	-	10	1310	c.599G>T	c.(598-600)aGa>aTa	p.R200I	ZNF558_ENST00000444186.2_Missense_Mutation_p.R129I|ZNF558_ENST00000301475.1_Missense_Mutation_p.R200I			Q96NG5	ZN558_HUMAN	zinc finger protein 558	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						ATTATGGATTCTCTTATGAAT	0.408													4	54					2.56e-06	2.86294e-06	1	1	0	A	8922567	C	A	8922567	3	1	48	1	0	0	0	0	1	0	0	0	18045	913	32	2	613	2	ZNF558	19	8922567	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	309573	8922567	50206416	3799	8193										
MUC16	94025	broad.mit.edu	37	chr19	9014641	9014641	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccctgtccactccagggctTttggggtcaagacggtgggt	14	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9014641T>C	ENST00000397910.4	-	31	38537	c.38334A>G	c.(38332-38334)aaA>aaG	p.K12778K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12780	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCCAGGGCTTTTGGGGTCAA	0.557													52	70					0	0	1	0	0	C	9014641	T	C	9014641	2	2	48	1	0	0	0	0	0	0	0	1	10020	1838	64	4		4	MUC16	19	9014641	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	92074	9014641	50114342	3800	8194										
MUC16	94025	broad.mit.edu	37	chr19	9046194	9046194	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttgtctgagttgggagagCtgtgctagtctctgcaccag	14	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9046194C>A	ENST00000397910.4	-	5	35640	c.35437G>T	c.(35437-35439)Gct>Tct	p.A11813S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11815	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.A7446T(1)|p.A11813T(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGGGAGAGCTGTGCTAGTC	0.463													4	42					0.00024832	0.000265255	1	1	0	A	9046194	C	A	9046194	3	1	48	1	0	0	0	0	1	0	0	0	10020	797	28	5	8406	5	MUC16	19	9046194	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	31553	9046194	50082789	3801	8195										
MUC16	94025	broad.mit.edu	37	chr19	9049889	9049889	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctagagtttgaataaccGgacttctctctgccccagaa	7	12	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9049889G>A	ENST00000397910.4	-	5	31945	c.31742C>T	c.(31741-31743)cCg>cTg	p.P10581L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10583	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGAATAACCGGACTTCTCTC	0.483													47	55					0	0	1	0	0	A	9049889	G	A	9049889	3	1	48	1	0	0	0	0	1	0	0	0	10020	1116	39	1	12101	1	MUC16	19	9049889	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3695	9049889	50079094	3802	8196										
MUC16	94025	broad.mit.edu	37	chr19	9062453	9062453	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttccaaagtggtcagtctCtcatgggaggtgctgctcaa	11	10	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9062453C>T	ENST00000397910.4	-	3	25196	c.24993G>A	c.(24991-24993)gaG>gaA	p.E8331E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8333	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTCAGTCTCTCATGGGAGG	0.498													42	88					0	0	1	0	0	T	9062453	C	T	9062453	2	4	48	1	0	0	0	0	0	0	0	1	10020	912	32	3		3	MUC16	19	9062453	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	12564	9062453	50066530	3803	8197										
MUC16	94025	broad.mit.edu	37	chr19	9085753	9085753	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggatgtgctgcttccagaaGagactgaattctcatgggta	12	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9085753G>T	ENST00000397910.4	-	1	6265	c.6062C>A	c.(6061-6063)tCt>tAt	p.S2021Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2021	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTTCCAGAAGAGACTGAATT	0.468													33	64					8.73648e-17	1.16604e-16	1	1	0	T	9085753	G	T	9085753	3	4	48	1	0	0	0	0	1	0	0	0	10020	942	33	2	37797	2	MUC16	19	9085753	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23300	9085753	50043230	3804	8198										
MUC16	94025	broad.mit.edu	37	chr19	9089181	9089181	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttactctggaaacagaagtCtcaggttgagacacagatgg	11	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9089181C>A	ENST00000397910.4	-	1	2837	c.2634G>T	c.(2632-2634)gaG>gaT	p.E878D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	878	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAACAGAAGTCTCAGGTTGAG	0.478													11	30					1.11149e-13	1.42822e-13	1	1	0	A	9089181	C	A	9089181	3	1	48	1	0	0	0	0	1	0	0	0	10020	912	32	2	41225	2	MUC16	19	9089181	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3428	9089181	50039802	3805	8199										
OR7G2	390882	broad.mit.edu	37	chr19	9213578	9213578	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcataggccattgctgcaagGagacaattttccaagccagc	9	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9213578G>T	ENST00000305456.2	-	1	404	c.405C>A	c.(403-405)ctC>ctA	p.L135L		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						TTGCTGCAAGGAGACAATTTT	0.507													17	76					1.15088e-07	1.32965e-07	1	1	0	T	9213578	G	T	9213578	2	4	48	1	0	0	0	0	0	0	0	1	11269	1161	41	2		2	OR7G2	19	9213578	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	124397	9213578	49915405	3806	8200										
ZNF317	57693	broad.mit.edu	37	chr19	9271130	9271130	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcccttaggagccacgcaaGaactcacctcaaagagaagc	9	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9271130G>T	ENST00000247956.6	+	7	1114	c.809G>T	c.(808-810)aGa>aTa	p.R270I	ZNF317_ENST00000360385.3_Missense_Mutation_p.R238I	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						AGCCACGCAAGAACTCACCTC	0.567													40	66					1.47197e-15	1.94065e-15	1	1	0	T	9271130	G	T	9271130	3	4	48	1	0	0	0	0	1	0	0	0	17891	942	33	2	831	2	ZNF317	19	9271130	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	57552	9271130	49857853	3807	8201										
OR7D2	162998	broad.mit.edu	37	chr19	9296569	9296569	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgtccatgtacctggtgAcggtgctgggaaacctgctc	12	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9296569A>G	ENST00000344248.2	+	1	291	c.112A>G	c.(112-114)Acg>Gcg	p.T38A		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	38					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						GTACCTGGTGACGGTGCTGGG	0.507													12	83					0	0	1	0	0	G	9296569	A	G	9296569	3	3	48	1	0	0	0	0	1	0	0	0	11265	275	10	4	114	4	OR7D2	19	9296569	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	25439	9296569	49832414	3808	8202										
OR7E24	26648	broad.mit.edu	37	chr19	9362120	9362120	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatggatgacatgctcctgaGtgtgatggcctatgaccggt	13	8	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9362120G>A	ENST00000456448.1	+	1	515	c.401G>A	c.(400-402)aGt>aAt	p.S134N		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						ATGCTCCTGAGTGTGATGGCC	0.478													21	35					0	0	1	0	0	A	9362120	G	A	9362120	3	1	48	1	0	0	0	0	1	0	0	0	11267	1029	36	3	403	3	OR7E24	19	9362120	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65551	9362120	49766863	3809	8203										
ZNF560	147741	broad.mit.edu	37	chr19	9577913	9577913	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttcatacattcatagggTttctctccagcgtgtgttcg	8	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9577913T>C	ENST00000301480.4	-	10	1923	c.1710A>G	c.(1708-1710)aaA>aaG	p.K570K		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						ATTCATAGGGTTTCTCTCCAG	0.398													35	63					0	0	1	0	0	C	9577913	T	C	9577913	2	2	48	1	0	0	0	0	0	0	0	1	18047	1722	60	4		4	ZNF560	19	9577913	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	215793	9577913	49551070	3810	8204										
ZNF560	147741	broad.mit.edu	37	chr19	9583919	9583919	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccaagagatgacactgggTttaaagagctgaaatccttt	9	7	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9583919T>C	ENST00000301480.4	-	5	387	c.174A>G	c.(172-174)aaA>aaG	p.K58K		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	58	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TGACACTGGGTTTAAAGAGCT	0.453													61	75					0	0	1	0	0	C	9583919	T	C	9583919	2	2	48	1	0	0	0	0	0	0	0	1	18047	1722	60	4		4	ZNF560	19	9583919	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	6006	9583919	49545064	3811	8205										
ZNF426	79088	broad.mit.edu	37	chr19	9639180	9639180	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctaaaggaactggaacacGtgaaggctttcccacactcc	8	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9639180G>A	ENST00000593003.1	-	6	1904	c.1427C>T	c.(1426-1428)aCg>aTg	p.T476M	ZNF426_ENST00000535489.1_Missense_Mutation_p.T514M|ZNF426_ENST00000253115.2_Missense_Mutation_p.T514M			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						ACTGGAACACGTGAAGGCTTT	0.428													20	34					0	0	1	0	0	A	9639180	G	A	9639180	3	1	48	1	0	0	0	0	1	0	0	0	17956	1145	40	1	127	1	ZNF426	19	9639180	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	55261	9639180	49489803	3812	8206										
ZNF121	7675	broad.mit.edu	37	chr19	9677366	9677366	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttacattcgtagggtttTtctacagtatgcattttaac	6	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:9677366T>G	ENST00000586602.1	-	6	839	c.423A>C	c.(421-423)gaA>gaC	p.E141D	ZNF121_ENST00000320451.6_Missense_Mutation_p.E141D			P58317	ZN121_HUMAN	zinc finger protein 121	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(4)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	24						CGTAGGGTTTTTCTACAGTAT	0.378													17	24					0	0	1	0	0	G	9677366	T	G	9677366	3	3	48	1	0	0	0	0	1	0	0	0	17776	1838	64	4	753	4	ZNF121	19	9677366	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	38186	9677366	49451617	3813	8207										
COL5A3	50509	broad.mit.edu	37	chr19	10079070	10079070	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggacactcacagggtctccCttgggaccagggggtccctg	14	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:10079070C>A	ENST00000264828.3	-	59	4390	c.4305G>T	c.(4303-4305)aaG>aaT	p.K1435N		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1435	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CAGGGTCTCCCTTGGGACCAG	0.607													65	109					6.8682e-38	9.89239e-38	1	1	0	A	10079070	C	A	10079070	3	1	48	1	0	0	0	0	1	0	0	0	3721	680	24	5	968	5	COL5A3	19	10079070	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	401704	10079070	49049913	3814	8208										
ICAM4	3386	broad.mit.edu	37	chr19	10398049	10398049	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgtgacctgcgcaggaaaaAcacgctgggccacctccagg	12	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:10398049A>G	ENST00000393717.2	+	1	370	c.361A>G	c.(361-363)Aca>Gca	p.T121A	CTD-2369P2.8_ENST00000589379.1_RNA|ICAM4_ENST00000380770.3_Missense_Mutation_p.T121A|ICAM4_ENST00000340992.4_Missense_Mutation_p.T121A	NM_022377.3	NP_071772.1	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	121	Ig-like C2-type 1.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGCAGGAAAAACACGCTGGGC	0.672													12	8					0	0	1	0	0	G	10398049	A	G	10398049	3	3	48	1	0	0	0	0	1	0	0	0	7525	43	2	4	363	4	ICAM4	19	10398049	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	318979	10398049	48730934	3815	8209										
ILF3	3609	broad.mit.edu	37	chr19	10793809	10793809	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttttccctgagaacgtaaaAcagcaggggccgatcctgac	11	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:10793809A>C	ENST00000449870.1	+	14	1874	c.1557A>C	c.(1555-1557)aaA>aaC	p.K519N	ILF3_ENST00000588657.1_Missense_Mutation_p.K519N|ILF3_ENST00000318511.3_Intron|ILF3_ENST00000407004.3_Missense_Mutation_p.K519N|ILF3_ENST00000420083.1_Intron|ILF3_ENST00000590261.1_Intron|ILF3_ENST00000589998.1_Intron|ILF3_ENST00000592763.1_Missense_Mutation_p.K519N|ILF3_ENST00000250241.8_Intron	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	516					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			AGAACGTAAAACAGCAGGGGC	0.562													63	108					0	0	1	0	0	C	10793809	A	C	10793809	3	2	48	1	0	0	0	0	1	0	0	0	7755	40	2	4	1607	4	ILF3	19	10793809	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	395760	10793809	48335174	3816	8210										
ILF3	3609	broad.mit.edu	37	chr19	10794354	10794354	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggaggccccatgcacaacGaagtgcccccaccccccaac	9	19	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:10794354G>A	ENST00000449870.1	+	16	2223	c.1906G>A	c.(1906-1908)Gaa>Aaa	p.E636K	ILF3_ENST00000588657.1_Missense_Mutation_p.E636K|ILF3_ENST00000318511.3_Missense_Mutation_p.E632K|ILF3_ENST00000407004.3_Missense_Mutation_p.E636K|ILF3_ENST00000420083.1_Missense_Mutation_p.E632K|ILF3_ENST00000590261.1_Missense_Mutation_p.E632K|ILF3_ENST00000589998.1_Missense_Mutation_p.E632K|ILF3_ENST00000592763.1_Missense_Mutation_p.E636K|ILF3_ENST00000250241.8_Missense_Mutation_p.E632K	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	632	Interaction with PRMT1.|Poly-Pro.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CATGCACAACGAAGTGCCCCC	0.622													21	38					0	0	1	0	0	A	10794354	G	A	10794354	3	1	48	1	0	0	0	0	1	0	0	0	7755	1059	37	1	1964	1	ILF3	19	10794354	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	545	10794354	48334629	3817	8211										
SMARCA4	6597	broad.mit.edu	37	chr19	11114067	11114067	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagtggctcagaagaagaGgaagaggtaagagtgcattt	15	3	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:11114067G>T	ENST00000358026.2	+	13	2279	c.1995G>T	c.(1993-1995)gaG>gaT	p.E665D	SMARCA4_ENST00000344626.4_Missense_Mutation_p.E665D|SMARCA4_ENST00000590574.1_Missense_Mutation_p.E665D|SMARCA4_ENST00000589677.1_Missense_Mutation_p.E665D|SMARCA4_ENST00000429416.3_Missense_Mutation_p.E665D|SMARCA4_ENST00000450717.3_Missense_Mutation_p.E665D|SMARCA4_ENST00000413806.3_Missense_Mutation_p.E665D|SMARCA4_ENST00000444061.3_Missense_Mutation_p.E665D|SMARCA4_ENST00000541122.2_Missense_Mutation_p.E665D	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	665	Poly-Glu.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CAGAAGAAGAGGAAGAGGTAA	0.507			"F, N, Mis"		NSCLC								19	98					0.012319	0.012659	1	1	0	T	11114067	G	T	11114067	3	4	48	1	0	0	0	0	1	0	0	0	14823	991	35	5	2041	5	SMARCA4	19	11114067	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	319713	11114067	48014916	3818	8212										
CCDC151	115948	broad.mit.edu	37	chr19	11545832	11545832	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccgccctgcacagaggagaTgtcatgatggggttggggct	17	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:11545832T>C	ENST00000356392.4	-	1	93	c.6A>G	c.(4-6)acA>acG	p.T2T	CCDC151_ENST00000591179.1_Silent_p.T2T|CCDC151_ENST00000545100.1_Intron|CCDC151_ENST00000586836.1_Intron	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	2										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						ACAGAGGAGATGTCATGATGG	0.642											OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	73					0	0	1	0	0	C	11545832	T	C	11545832	2	2	48	1	0	0	0	0	0	0	0	1	2804	1451	51	4		4	CCDC151	19	11545832	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	431765	11545832	47583151	3819	8213										
ZNF439	90594	broad.mit.edu	37	chr19	11978295	11978295	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtaactcatcttctaatatGaacatcagaggtgacactgg	9	8	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:11978295G>T	ENST00000304030.2	+	3	611	c.411G>T	c.(409-411)atG>atT	p.M137I	ZNF439_ENST00000455282.1_Start_Codon_SNP_p.M1I|ZNF439_ENST00000592534.1_Intron	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						CTTCTAATATGAACATCAGAG	0.423													68	134					1.08241e-25	1.52617e-25	1	1	0	T	11978295	G	T	11978295	3	4	48	1	0	0	0	0	1	0	0	0	17967	1290	45	2	421	2	ZNF439	19	11978295	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	432463	11978295	47150688	3820	8214										
ZNF700	90592	broad.mit.edu	37	chr19	12059468	12059468	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattttccattcaagcattcGaagacacatggtaatgcaca	6	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12059468G>A	ENST00000482090.1	+	3	993	c.575G>A	c.(574-576)cGa>cAa	p.R192Q	CTD-2006C1.12_ENST00000586394.1_RNA|ZNF700_ENST00000254321.5_Missense_Mutation_p.R210Q|ZNF763_ENST00000590798.1_Intron|ZNF763_ENST00000538752.1_Intron|ZNF763_ENST00000591944.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						TCAAGCATTCGAAGACACATG	0.378													32	67					0	0	1	0	0	A	12059468	G	A	12059468	3	1	48	1	0	0	0	0	1	0	0	0	18159	1058	37	1	643	1	ZNF700	19	12059468	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	81173	12059468	47069515	3821	8215										
ZNF433	163059	broad.mit.edu	37	chr19	12127029	12127029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctccagtgtgagttCgtttgtggataagatacaaa	10	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12127029C>T	ENST00000419886.2	-	5	839	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	CTD-2006C1.2_ENST00000495324.1_RNA|ZNF433_ENST00000344980.6_Missense_Mutation_p.R218Q|CTD-2006C1.2_ENST00000406892.2_RNA|CTD-2006C1.2_ENST00000476474.1_RNA			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						AGTGTGAGTTCGTTTGTGGAT	0.403													16	41					0	0	1	0	0	T	12127029	C	T	12127029	3	4	48	1	0	0	0	0	1	0	0	0	17963	884	31	1	1372	1	ZNF433	19	12127029	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67561	12127029	47001954	3822	8216										
ZNF20	7568	broad.mit.edu	37	chr19	12243602	12243602	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgagtcctttcatgatatcGaatggaactggaacaagtga	11	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12243602G>A	ENST00000334213.5	-	4	1623	c.1399C>T	c.(1399-1401)Cga>Tga	p.R467*	ZNF625-ZNF20_ENST00000430024.1_3'UTR|ZNF20_ENST00000600335.1_Intron	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						TCATGATATCGAATGGAACTG	0.403													23	73					0	0	1	0	0	A	12243602	G	A	12243602	4	1	48	1	0	0	0	0	0	1	0	0	17818	1066	37	1	203	1	ZNF20	19	12243602	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	116573	12243602	46885381	3823	8217										
ZNF20	7568	broad.mit.edu	37	chr19	12243874	12243874	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagttgtgaagcacatctaAagcctttcccacactgctta	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12243874A>C	ENST00000334213.5	-	4	1351	c.1127T>G	c.(1126-1128)tTt>tGt	p.F376C	ZNF625-ZNF20_ENST00000430024.1_3'UTR|ZNF20_ENST00000600335.1_Intron	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						AGCACATCTAAAGCCTTTCCC	0.418													11	48					0	0	1	0	0	C	12243874	A	C	12243874	3	2	48	1	0	0	0	0	1	0	0	0	17818	14	1	4	475	4	ZNF20	19	12243874	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	272	12243874	46885109	3824	8218										
ZNF20	7568	broad.mit.edu	37	chr19	12244261	12244261	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattcactcctgtgtgagttCtttcatgtactggaagggta	10	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12244261C>A	ENST00000334213.5	-	4	964	c.740G>T	c.(739-741)aGa>aTa	p.R247I	ZNF625-ZNF20_ENST00000430024.1_3'UTR|ZNF20_ENST00000600335.1_Intron	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						TGTGTGAGTTCTTTCATGTAC	0.403													29	59					9.39395e-14	1.21013e-13	1	1	0	A	12244261	C	A	12244261	3	1	48	1	0	0	0	0	1	0	0	0	17818	913	32	2	862	2	ZNF20	19	12244261	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	387	12244261	46884722	3825	8219										
ZNF625	90589	broad.mit.edu	37	chr19	12256655	12256655	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctttcccacaaaagttacaTttgtagggtccatctccact	6	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12256655T>G	ENST00000355738.1	-	4	727	c.378A>C	c.(376-378)aaA>aaC	p.K126N	ZNF625-ZNF20_ENST00000430024.1_Intron|ZNF625_ENST00000455799.1_3'UTR|ZNF625_ENST00000542938.1_Missense_Mutation_p.K126N|ZNF625_ENST00000439556.2_Missense_Mutation_p.K192N			Q96I27	ZN625_HUMAN	zinc finger protein 625	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						AAAAGTTACATTTGTAGGGTC	0.413													53	78					0	0	1	0	0	G	12256655	T	G	12256655	3	3	48	1	0	0	0	0	1	0	0	0	18105	1490	52	4	546	4	ZNF625	19	12256655	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	12394	12256655	46872328	3826	8220										
ZNF136	7695	broad.mit.edu	37	chr19	12298485	12298485	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtggtaaagctttcgtttCttcaacatcaattcgaatac	6	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12298485C>A	ENST00000343979.4	+	4	1432	c.1292C>A	c.(1291-1293)tCt>tAt	p.S431Y	ZNF136_ENST00000398616.2_Missense_Mutation_p.S365Y	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	431					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						GCTTTCGTTTCTTCAACATCA	0.388													4	32					0.150653	0.151842	1	1	0	A	12298485	C	A	12298485	3	1	48	1	0	0	0	0	1	0	0	0	17783	913	32	2	1306	2	ZNF136	19	12298485	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	41830	12298485	46830498	3827	8221										
ZNF443	10224	broad.mit.edu	37	chr19	12541287	12541287	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgagccaagagaatgcttTcccacattccttacattcat	6	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12541287T>G	ENST00000301547.5	-	4	1896	c.1699A>C	c.(1699-1701)Aaa>Caa	p.K567Q	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	567					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						GAGAATGCTTTCCCACATTCC	0.393													15	65					0	0	1	0	0	G	12541287	T	G	12541287	3	3	48	1	0	0	0	0	1	0	0	0	17972	1792	62	4	320	4	ZNF443	19	12541287	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	242802	12541287	46587696	3828	8222										
ZNF443	10224	broad.mit.edu	37	chr19	12542031	12542031	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaagggaaccggaaacacTgaaggctttcccacattgtt	10	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12542031T>G	ENST00000301547.5	-	4	1152	c.955A>C	c.(955-957)Agt>Cgt	p.S319R	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	319					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						CCGGAAACACTGAAGGCTTTC	0.438													65	108					0	0	1	0	0	G	12542031	T	G	12542031	3	3	48	1	0	0	0	0	1	0	0	0	17972	1580	55	4	1064	4	ZNF443	19	12542031	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	744	12542031	46586952	3829	8223										
ZNF709	163051	broad.mit.edu	37	chr19	12575681	12575681	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgcattatcatatgtcttCgatagcttggaagagaaatg	10	5	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12575681C>T	ENST00000397732.3	-	4	1226	c.1055G>A	c.(1054-1056)cGa>cAa	p.R352Q	ZNF709_ENST00000428311.1_Missense_Mutation_p.R352Q|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						CATATGTCTTCGATAGCTTGG	0.368													38	46					0	0	1	0	0	T	12575681	C	T	12575681	3	4	48	1	0	0	0	0	1	0	0	0	18168	884	31	1	874	1	ZNF709	19	12575681	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	33650	12575681	46553302	3830	8224										
ZNF709	163051	broad.mit.edu	37	chr19	12576017	12576017	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtgagttctttcatgatttCgaaaagaactgggatgactg	11	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12576017C>T	ENST00000397732.3	-	4	890	c.719G>A	c.(718-720)cGa>cAa	p.R240Q	ZNF709_ENST00000428311.1_Missense_Mutation_p.R240Q|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						TTCATGATTTCGAAAAGAACT	0.383													23	39					0	0	1	0	0	T	12576017	C	T	12576017	3	4	48	1	0	0	0	0	1	0	0	0	18168	884	31	1	1210	1	ZNF709	19	12576017	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	336	12576017	46552966	3831	8225										
ZNF564	163050	broad.mit.edu	37	chr19	12638272	12638272	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctccagtgtgagttCtttcatgtatctgaaataaa	7	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12638272C>A	ENST00000339282.7	-	4	846	c.650G>T	c.(649-651)aGa>aTa	p.R217I	ZNF709_ENST00000428311.1_Intron|CTD-2192J16.20_ENST00000593682.1_3'UTR	NM_144976.3	NP_659413.1			zinc finger protein 564									p.R217I(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						AGTGTGAGTTCTTTCATGTAT	0.403													47	84					1.8453e-21	2.54941e-21	1	1	0	A	12638272	C	A	12638272	3	1	48	1	0	0	0	0	1	0	0	0	18051	913	32	2	1015	2	ZNF564	19	12638272	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	62255	12638272	46490711	3832	8226										
ZNF791	163049	broad.mit.edu	37	chr19	12739611	12739611	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtgcaaaaaccttcatttCtcttgagaactttcgaagac	6	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12739611C>A	ENST00000343325.4	+	4	1430	c.1268C>A	c.(1267-1269)tCt>tAt	p.S423Y	ZNF791_ENST00000446165.1_3'UTR|ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000540038.1_Missense_Mutation_p.S314Y|ZNF791_ENST00000458122.3_Missense_Mutation_p.S391Y	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						ACCTTCATTTCTCTTGAGAAC	0.403													43	76					7.05121e-23	9.83114e-23	1	1	0	A	12739611	C	A	12739611	3	1	48	1	0	0	0	0	1	0	0	0	18211	913	32	2	1282	2	ZNF791	19	12739611	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	101339	12739611	46389372	3833	8227										
TNPO2	30000	broad.mit.edu	37	chr19	12825950	12825950	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacacattcttccgcacctCggggtcatcatccacagcca	7	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12825950C>T	ENST00000425528.1	-	9	1039	c.682G>A	c.(682-684)Gag>Aag	p.E228K	TNPO2_ENST00000592287.1_Missense_Mutation_p.E228K|TNPO2_ENST00000450764.2_Missense_Mutation_p.E228K|TNPO2_ENST00000441499.1_Missense_Mutation_p.E228K|TNPO2_ENST00000588216.1_Missense_Mutation_p.E228K|TNPO2_ENST00000356861.5_Missense_Mutation_p.E228K|TNPO2_ENST00000589956.1_Intron			O14787	TNPO2_HUMAN	transportin 2	228					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTCCGCACCTCGGGGTCATCA	0.617													24	37					0	0	1	0	0	T	12825950	C	T	12825950	3	4	48	1	0	0	0	0	1	0	0	0	16395	893	31	1	2079	1	TNPO2	19	12825950	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	86339	12825950	46303033	3834	8228										
MAST1	22983	broad.mit.edu	37	chr19	12958187	12958187	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacttcctctccaaacacttCgggagcaccgagagcatcac	7	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12958187C>T	ENST00000251472.4	+	5	450	c.411C>T	c.(409-411)ttC>ttT	p.F137F	MAST1_ENST00000591495.1_Silent_p.F133F	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	137					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CCAAACACTTCGGGAGCACCG	0.677											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	48					0	0	1	0	0	T	12958187	C	T	12958187	2	4	48	1	0	0	0	0	0	0	0	1	9373	883	31	1		1	MAST1	19	12958187	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	132237	12958187	46170796	3835	8229										
MAST1	22983	broad.mit.edu	37	chr19	12981886	12981886	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtgaccacaacgcccttcGaaaatacctctatccgcatt	5	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:12981886G>A	ENST00000251472.4	+	24	3202	c.3163G>A	c.(3163-3165)Gaa>Aaa	p.E1055K		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	1055	PDZ.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						AACGCCCTTCGAAAATACCTC	0.607													19	156					0	0	1	0	0	A	12981886	G	A	12981886	3	1	48	1	0	0	0	0	1	0	0	0	9373	1059	37	1	3257	1	MAST1	19	12981886	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23699	12981886	46147097	3836	8230										
SYCE2	256126	broad.mit.edu	37	chr19	13015378	13015378	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggctcttgttgatgttttcGatcagctcctgggctctctt	10	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:13015378G>A	ENST00000293695.7	-	3	252	c.234C>T	c.(232-234)atC>atT	p.I78I	SYCE2_ENST00000591229.1_5'UTR	NM_001105578.1	NP_001099048.1	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	78					cell division	central element				endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						TGATGTTTTCGATCAGCTCCT	0.552													54	98					0	0	1	0	0	A	13015378	G	A	13015378	2	1	48	1	0	0	0	0	0	0	0	1	15485	1048	37	1		1	SYCE2	19	13015378	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	33492	13015378	46113605	3837	8231										
LYL1	4066	broad.mit.edu	37	chr19	13211649	13211649	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccaccccagatccccactgAcctgttgaggaaggggtgag	12	14	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:13211649A>G	ENST00000264824.4	-	2	696		c.e2+1			NM_005583.4	NP_005574.2	P12980	LYL1_HUMAN	lymphoblastic leukemia derived sequence 1						B cell differentiation|blood vessel maturation|definitive hemopoiesis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			cervix(1)|endometrium(2)|kidney(1)|lung(2)|prostate(1)	7			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)			ATCCCCACTGACCTGTTGAGG	0.652			T	TRB@	T-ALL								8	7					0	0	1	0	0	G	13211649	A	G	13211649	5	3	48	1	0	0	0	0	0	0	1	0	9151	289	10	4	517	4	LYL1	19	13211649	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	196271	13211649	45917334	3838	8232										
CACNA1A	773	broad.mit.edu	37	chr19	13482541	13482541	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgagcggccgcagcactcGaactgccctcagcgtccgta	11	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:13482541G>A	ENST00000360228.5	-	4	591	c.592C>T	c.(592-594)Cga>Tga	p.R198*	CACNA1A_ENST00000573710.2_Nonsense_Mutation_p.R198*	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	198					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGCAGCACTCGAACTGCCCTC	0.582													4	11					0	0	1	0	0	A	13482541	G	A	13482541	4	1	48	1	0	0	0	0	0	1	0	0	2556	1066	37	1	7218	1	CACNA1A	19	13482541	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	270892	13482541	45646442	3839	8233										
CLEC17A	388512	broad.mit.edu	37	chr19	14705455	14705455	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctcctcagcaaaggaaacaGagaaacccccacttccttgc	6	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:14705455G>T	ENST00000547437.1	+	6	399	c.322G>T	c.(322-324)Gag>Tag	p.E108*	CLEC17A_ENST00000417570.1_Nonsense_Mutation_p.E108*|CLEC17A_ENST00000397439.2_Nonsense_Mutation_p.E91*	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	108						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										AAAGGAAACAGAGAAACCCCC	0.572													23	59					7.87624e-14	1.01695e-13	1	1	0	T	14705455	G	T	14705455	4	4	48	1	0	0	0	0	0	1	0	0	3524	943	33	2	289	2	CLEC17A	19	14705455	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1222914	14705455	44423528	3840	8234										
OR7C1	26664	broad.mit.edu	37	chr19	14910876	14910876	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacagcccaaagagaatgaActgaatctctgacgttgctg	10	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:14910876A>G	ENST00000248073.2	-	1	147	c.73T>C	c.(73-75)Ttc>Ctc	p.F25L	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	25					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						AAGAGAATGAACTGAATCTCT	0.483													39	81					0	0	1	0	0	G	14910876	A	G	14910876	3	3	48	1	0	0	0	0	1	0	0	0	11263	43	2	4	891	4	OR7C1	19	14910876	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	205421	14910876	44218107	3841	8235										
OR7A10	390892	broad.mit.edu	37	chr19	14952650	14952650	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctctgaaattcccaggaGaagaaattctaaaattattg	6	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:14952650G>T	ENST00000248058.1	-	1	39	c.40C>A	c.(40-42)Ctc>Atc	p.L14I		NM_001005190.1	NP_001005190.1	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A, member 10	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|stomach(1)	19	Ovarian(108;0.203)					ATTCCCAGGAGAAGAAATTCT	0.443													26	43					2.41591e-17	3.2383e-17	1	1	0	T	14952650	G	T	14952650	3	4	48	1	0	0	0	0	1	0	0	0	11260	942	33	2	893	2	OR7A10	19	14952650	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	41774	14952650	44176333	3842	8236										
OR7C2	26658	broad.mit.edu	37	chr19	15052725	15052725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgaacccccggctctgtgGactgctggttctggggtcct	13	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:15052725G>A	ENST00000248072.3	+	1	425	c.425G>A	c.(424-426)gGa>gAa	p.G142E		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					CGGCTCTGTGGACTGCTGGTT	0.542													52	85					0	0	1	0	0	A	15052725	G	A	15052725	3	1	48	1	0	0	0	0	1	0	0	0	11264	1174	41	3	427	3	OR7C2	19	15052725	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	100075	15052725	44076258	3843	8237										
CYP4F8	11283	broad.mit.edu	37	chr19	15739598	15739598	+	RNA	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accccttccgcttcgacccaGaaaacgcccagaagaggtca	8	16	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:15739598G>A	ENST00000441682.2	+	0	1403							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CTTCGACCCAGAAAACGCCCA	0.602													28	60					0	0	1	0	0	A	15739598	G	A	15739598	1	1	48	0	1	0	0	0	0	0	0	0	4214	943	33	3		3	CYP4F8	19	15739598	RNA	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	686873	15739598	43389385	3844	8238										
CYP4F12	66002	broad.mit.edu	37	chr19	15795927	15795927	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggtcctgtacaaccttgcGaggcacccagaataccagga	11	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:15795927G>A	ENST00000550308.1	+	9	1415	c.1035G>A	c.(1033-1035)gcG>gcA	p.A345A	CYP4F12_ENST00000324632.9_Silent_p.A345A	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ACAACCTTGCGAGGCACCCAG	0.592													22	36					0	0	1	0	0	A	15795927	G	A	15795927	2	1	48	1	0	0	0	0	0	0	0	1	4210	1045	37	1		1	CYP4F12	19	15795927	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	56329	15795927	43333056	3845	8239										
CYP4F2	8529	broad.mit.edu	37	chr19	15997104	15997104	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtcctcatcagataacttCttcccgtcttcatcctggag	6	13	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:15997104C>A	ENST00000221700.5	-	8	1028	c.933G>T	c.(931-933)aaG>aaT	p.K311N	CYP4F2_ENST00000011989.7_Intron|CYP4F2_ENST00000592328.1_Missense_Mutation_p.K311N	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	311					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CAGATAACTTCTTCCCGTCTT	0.532													97	158					9.72315e-31	1.38941e-30	1	1	0	A	15997104	C	A	15997104	3	1	48	1	0	0	0	0	1	0	0	0	4211	912	32	2	653	2	CYP4F2	19	15997104	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	201177	15997104	43131879	3846	8240										
NXNL1	115861	broad.mit.edu	37	chr19	17571484	17571484	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagccgcccgcagtacataGaactcatctgtgagccgcac	10	14	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:17571484G>T	ENST00000301944.2	-	1	279	c.195C>A	c.(193-195)ttC>ttA	p.F65L	CTD-2521M24.10_ENST00000594663.1_5'UTR	NM_138454.1	NP_612463.1	Q96CM4	NXNL1_HUMAN	nucleoredoxin-like 1	65	Thioredoxin.				cell redox homeostasis	nuclear outer membrane				central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	6						GCAGTACATAGAACTCATCTG	0.597													42	74					4.14481e-20	5.66236e-20	1	1	0	T	17571484	G	T	17571484	3	4	48	1	0	0	0	0	1	0	0	0	10835	933	33	2	451	2	NXNL1	19	17571484	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1574380	17571484	41557499	3847	8241										
SLC27A1	376497	broad.mit.edu	37	chr19	17598015	17598015	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagcgggcatctggggaaaAgtttgatcaagttctgctct	13	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:17598015A>C	ENST00000252595.7	+	3	692	c.595A>C	c.(595-597)Agt>Cgt	p.S199R	SLC27A1_ENST00000442725.1_Missense_Mutation_p.S199R|SLC27A1_ENST00000598424.1_Missense_Mutation_p.S20R	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	199	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TCTGGGGAAAAGTTTGATCAA	0.647													10	51					0	0	1	0	0	C	17598015	A	C	17598015	3	2	48	1	0	0	0	0	1	0	0	0	14579	72	3	4	605	4	SLC27A1	19	17598015	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	26531	17598015	41530968	3848	8242										
JAK3	3718	broad.mit.edu	37	chr19	17948837	17948837	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatggcgacagccccggtaAatcttggtgaaggacccatg	12	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:17948837A>C	ENST00000458235.1	-	12	1704	c.1605T>G	c.(1603-1605)atT>atG	p.I535M	JAK3_ENST00000534444.1_Missense_Mutation_p.I535M|JAK3_ENST00000527670.1_Missense_Mutation_p.I535M	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	535	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						AGCCCCGGTAAATCTTGGTGA	0.592		2	Mis		"acute megakaryocytic leukemia, ETP ALL"								4	167					0	0	1	0	0	C	17948837	A	C	17948837	3	2	48	1	0	0	0	0	1	0	0	0	7982	10	1	4	1821	4	JAK3	19	17948837	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	350822	17948837	41180146	3849	8243										
SLC5A5	6528	broad.mit.edu	37	chr19	17986847	17986847	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgtcctggcacgcggtgtCatgcttgtgggcgggccccg	17	12	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:17986847C>A	ENST00000222248.3	+	5	977	c.630C>A	c.(628-630)gtC>gtA	p.V210V		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	210					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CACGCGGTGTCATGCTTGTGG	0.607													25	59					1.37878e-21	1.90629e-21	1	1	0	A	17986847	C	A	17986847	2	1	48	1	0	0	0	0	0	0	0	1	14722	813	29	2		2	SLC5A5	19	17986847	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	38010	17986847	41142136	3850	8244										
IL12RB1	0	broad.mit.edu	37	chr19	18170414	18170414	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaccctctctgagcctcaAcgatcacatctgtaaagtac	5	15	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:18170414A>G	ENST00000593993.1	-	17	2145	c.1980T>C	c.(1978-1980)cgT>cgC	p.R660R	IL12RB1_ENST00000600835.1_3'UTR|IL12RB1_ENST00000430026.2_3'UTR			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	0					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						ctgagcctcaacgatcacatc	0.527													11	17					0	0	1	0	0	G	18170414	A	G	18170414	2	3	48	1	0	0	0	0	0	0	0	1	7669	58	2	4		4	IL12RB1	19	18170414	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	183567	18170414	40958569	3851	8245										
LRRC25	126364	broad.mit.edu	37	chr19	18507553	18507553	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaggtcactggaagctctCgcaggccgttcccagacagg	13	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:18507553C>T	ENST00000339007.3	-	1	874	c.221G>A	c.(220-222)cGa>cAa	p.R74Q	LRRC25_ENST00000595840.1_Missense_Mutation_p.R74Q	NM_145256.2	NP_660299.2	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25	74						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|skin(1)	8						TGGAAGCTCTCGCAGGCCGTT	0.612													15	29					0	0	1	0	0	T	18507553	C	T	18507553	3	4	48	1	0	0	0	0	1	0	0	0	9024	884	31	1	704	1	LRRC25	19	18507553	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	337139	18507553	40621430	3852	8246										
YJEFN3	374887	broad.mit.edu	37	chr19	19643488	19643488	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagctgctggaggattatcGctttgggcggcagcagctcg	17	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:19643488G>A	ENST00000514277.3	+	3	292	c.257G>A	c.(256-258)cGc>cAc	p.R86H	CTC-260F20.3_ENST00000586674.1_3'UTR|CTC-260F20.3_ENST00000555938.1_Intron|YJEFN3_ENST00000436027.4_Missense_Mutation_p.R36H	NM_198537.3	NP_940939.2	A6XGL0	YJEN3_HUMAN	YjeF N-terminal domain containing 3	86	YjeF N-terminal.									NS(1)|breast(1)|lung(3)	5						GAGGATTATCGCTTTGGGCGG	0.642											OREG0025384	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	1	0	0	A	19643488	G	A	19643488	3	1	48	1	0	0	0	0	1	0	0	0	17543	1087	38	1	267	1	YJEFN3	19	19643488	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1135935	19643488	39485495	3853	8247										
ZNF101	94039	broad.mit.edu	37	chr19	19790391	19790391	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactggaaagaggtcctataAatgtagggaaatagtgagag	13	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:19790391A>C	ENST00000592502.1	+	4	703	c.593A>C	c.(592-594)aAa>aCa	p.K198T	ZNF101_ENST00000444249.2_3'UTR|ZNF101_ENST00000415784.2_Missense_Mutation_p.K78T			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						AGGTCCTATAAATGTAGGGAA	0.383													30	46					0	0	1	0	0	C	19790391	A	C	19790391	3	2	48	1	0	0	0	0	1	0	0	0	17771	14	1	4	607	4	ZNF101	19	19790391	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	146903	19790391	39338592	3854	8248										
ZNF626	199777	broad.mit.edu	37	chr19	20808063	20808063	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagtggttaaaggctttgCcacattcttcacatttgtag	9	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:20808063C>T	ENST00000601440.1	-	4	766	c.620G>A	c.(619-621)gGc>gAc	p.G207D	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						AAAGGCTTTGCCACATTCTTC	0.368													22	39					0	0	1	0	0	T	20808063	C	T	20808063	3	4	48	1	0	0	0	0	1	0	0	0	18106	739	26	3	970	3	ZNF626	19	20808063	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1017672	20808063	38320920	3855	8249										
ZNF85	7639	broad.mit.edu	37	chr19	21132912	21132912	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttaccaaacataagaaaaTtcatactggagagaaaccct	5	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21132912T>G	ENST00000601023.1	+	2	2061	c.1415T>G	c.(1414-1416)aTt>aGt	p.I472S	ZNF85_ENST00000328178.8_Missense_Mutation_p.I531S|ZNF85_ENST00000345030.6_Missense_Mutation_p.I498S			Q03923	ZNF85_HUMAN	zinc finger protein 85	531						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						CATAAGAAAATTCATACTGGA	0.348													19	23					0	0	1	0	0	G	21132912	T	G	21132912	3	3	48	1	0	0	0	0	1	0	0	0	18236	1493	52	4	1606	4	ZNF85	19	21132912	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	324849	21132912	37996071	3856	8250										
ZNF714	148206	broad.mit.edu	37	chr19	21300262	21300262	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgaagaatgtggtaaagcTtttaaccacccttcagccct	8	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21300262T>G	ENST00000596143.1	+	5	1117	c.792T>G	c.(790-792)gcT>gcG	p.A264A	ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000291770.7_3'UTR	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						GTGGTAAAGCTTTTAACCACC	0.373													9	24					0	0	1	0	0	G	21300262	T	G	21300262	2	3	48	1	0	0	0	0	0	0	0	1	18173	1596	56	4		4	ZNF714	19	21300262	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	167350	21300262	37828721	3857	8251										
ZNF431	170959	broad.mit.edu	37	chr19	21365476	21365476	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccagagcaagacataaaaGattcttttcaacaagtaata	7	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21365476G>T	ENST00000311048.7	+	5	514	c.370G>T	c.(370-372)Gat>Tat	p.D124Y	ZNF431_ENST00000600692.1_Missense_Mutation_p.R131I|ZNF431_ENST00000594425.1_Intron	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						AGACATAAAAGATTCTTTTCA	0.333													20	25					5.03518e-11	6.23768e-11	1	1	0	T	21365476	G	T	21365476	3	4	48	1	0	0	0	0	1	0	0	0	17961	942	33	2	388	2	ZNF431	19	21365476	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	65214	21365476	37763507	3858	8252										
ZNF493	284443	broad.mit.edu	37	chr19	21606093	21606093	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattagagagaattcttaccGatgtgaagaatgtggcaaag	11	4	1	4	rs145782852		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21606093G>A	ENST00000392288.2	+	4	741	c.632G>A	c.(631-633)cGa>cAa	p.R211Q	ZNF493_ENST00000355504.4_Missense_Mutation_p.R83Q|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R83Q(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						AATTCTTACCGATGTGAAGAA	0.353													14	34					0	0	1	0	0	A	21606093	G	A	21606093	3	1	48	1	0	0	0	0	1	0	0	0	18000	1058	37	1	709	1	ZNF493	19	21606093	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	240617	21606093	37522890	3859	8253										
ZNF493	284443	broad.mit.edu	37	chr19	21606234	21606234	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttactacacataagagaaTtcatactggacagaaaccct	5	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21606234T>G	ENST00000392288.2	+	4	882	c.773T>G	c.(772-774)aTt>aGt	p.I258S	ZNF493_ENST00000355504.4_Missense_Mutation_p.I130S|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CATAAGAGAATTCATACTGGA	0.368													15	38					0	0	1	0	0	G	21606234	T	G	21606234	3	3	48	1	0	0	0	0	1	0	0	0	18000	1493	52	4	850	4	ZNF493	19	21606234	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	141	21606234	37522749	3860	8254										
ZNF429	353088	broad.mit.edu	37	chr19	21719871	21719871	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaatacatactggtgagaAaccctacaaatgtgaagaat	9	6	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21719871A>C	ENST00000358491.4	+	4	1224	c.1016A>C	c.(1015-1017)aAa>aCa	p.K339T	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						ACTGGTGAGAAACCCTACAAA	0.388													4	58					0	0	1	0	0	C	21719871	A	C	21719871	3	2	48	1	0	0	0	0	1	0	0	0	17958	14	1	4	1030	4	ZNF429	19	21719871	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	113637	21719871	37409112	3861	8255										
ZNF100	163227	broad.mit.edu	37	chr19	21909894	21909894	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggaccagttaaagcctttgCcgcattcttcacatttgtag	8	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21909894C>T	ENST00000358296.6	-	5	1418	c.1220G>A	c.(1219-1221)gGc>gAc	p.G407D	ZNF100_ENST00000305570.6_Missense_Mutation_p.G343D	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						AAAGCCTTTGCCGCATTCTTC	0.378													7	48					0	0	1	0	0	T	21909894	C	T	21909894	3	4	48	1	0	0	0	0	1	0	0	0	17770	739	26	3	412	3	ZNF100	19	21909894	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	190023	21909894	37219089	3862	8256										
ZNF43	7594	broad.mit.edu	37	chr19	21991559	21991559	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttgccacattcttcacatTtgtagggtttctctccagta	6	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21991559T>G	ENST00000594012.1	-	7	1776	c.1262A>C	c.(1261-1263)aAa>aCa	p.K421T	ZNF43_ENST00000595461.1_Missense_Mutation_p.K421T|ZNF43_ENST00000354959.4_Missense_Mutation_p.K427T|ZNF43_ENST00000598381.1_Missense_Mutation_p.K421T	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TTCTTCACATTTGTAGGGTTT	0.393													37	44					0	0	1	0	0	G	21991559	T	G	21991559	3	3	48	1	0	0	0	0	1	0	0	0	17959	1841	64	4	1153	4	ZNF43	19	21991559	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	81665	21991559	37137424	3863	8257										
ZNF43	7594	broad.mit.edu	37	chr19	21992001	21992001	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagaatttctctccagtgcGaattatcttatgggtagtaa	9	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:21992001G>A	ENST00000594012.1	-	7	1334	c.820C>T	c.(820-822)Cgc>Tgc	p.R274C	ZNF43_ENST00000595461.1_Missense_Mutation_p.R274C|ZNF43_ENST00000354959.4_Missense_Mutation_p.R280C|ZNF43_ENST00000598381.1_Missense_Mutation_p.R274C	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TCTCCAGTGCGAATTATCTTA	0.333													19	31					0	0	1	0	0	A	21992001	G	A	21992001	3	1	48	1	0	0	0	0	1	0	0	0	17959	1058	37	1	1595	1	ZNF43	19	21992001	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	442	21992001	37136982	3864	8258										
ZNF257	113835	broad.mit.edu	37	chr19	22271895	22271895	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggtcttcataccttattcGacataagataattcatactg	5	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:22271895G>A	ENST00000594947.1	+	4	1487	c.1343G>A	c.(1342-1344)cGa>cAa	p.R448Q		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TACCTTATTCGACATAAGATA	0.378													20	28					0	0	1	0	0	A	22271895	G	A	22271895	3	1	48	1	0	0	0	0	1	0	0	0	17857	1058	37	1	1357	1	ZNF257	19	22271895	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	279894	22271895	36857088	3865	8259										
ZNF676	163223	broad.mit.edu	37	chr19	22363533	22363533	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctccagcatgaattCtcttgtgttcagtaaggctt	8	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:22363533C>A	ENST00000397121.2	-	3	1303	c.986G>T	c.(985-987)aGa>aTa	p.R329I		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGCATGAATTCTCTTGTGTTC	0.408													8	78					9.31168e-06	1.03131e-05	1	1	0	A	22363533	C	A	22363533	3	1	48	1	0	0	0	0	1	0	0	0	18139	913	32	2	784	2	ZNF676	19	22363533	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	91638	22363533	36765450	3866	8260										
ZNF676	163223	broad.mit.edu	37	chr19	22364033	22364033	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggaattctctctagtataAattctttcatgttgagatag	7	5	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:22364033A>C	ENST00000397121.2	-	3	803	c.486T>G	c.(484-486)atT>atG	p.I162M		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CTCTAGTATAAATTCTTTCAT	0.338													20	42					0	0	1	0	0	C	22364033	A	C	22364033	3	2	48	1	0	0	0	0	1	0	0	0	18139	10	1	4	1284	4	ZNF676	19	22364033	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	500	22364033	36764950	3867	8261										
ZNF676	163223	broad.mit.edu	37	chr19	22364261	22364261	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgttacactcatccacattGgtacaactaatttttaagtg	5	9	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:22364261G>T	ENST00000397121.2	-	3	575	c.258C>A	c.(256-258)acC>acA	p.T86T		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CATCCACATTGGTACAACTAA	0.333													24	52					1.64293e-13	2.10822e-13	1	1	0	T	22364261	G	T	22364261	2	4	48	1	0	0	0	0	0	0	0	1	18139	1335	47	5		5	ZNF676	19	22364261	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	228	22364261	36764722	3868	8262										
ZNF99	7652	broad.mit.edu	37	chr19	22939559	22939559	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttcataagggttgaggaaTtgttaaaagctttgccacat	10	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:22939559T>G	ENST00000397104.3	-	7	2611	c.2612A>C	c.(2611-2613)aAt>aCt	p.N871T						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GGTTGAGGAATTGTTAAAAGC	0.358													16	35					0	0	1	0	0	G	22939559	T	G	22939559	3	3	48	1	0	0	0	0	1	0	0	0	18245	1493	52	4	504	4	ZNF99	19	22939559	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	575298	22939559	36189424	3869	8263										
ZNF99	7652	broad.mit.edu	37	chr19	22940624	22940624	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttccagtatgaattatcTtatgtttcctaagggctgag	8	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:22940624T>G	ENST00000397104.3	-	5	1813	c.1814A>C	c.(1813-1815)aAg>aCg	p.K605T	ZNF99_ENST00000596209.1_Missense_Mutation_p.K696T					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATGAATTATCTTATGTTTCCT	0.363													27	50					0	0	1	0	0	G	22940624	T	G	22940624	3	3	48	1	0	0	0	0	1	0	0	0	18245	1609	56	4	1310	4	ZNF99	19	22940624	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1065	22940624	36188359	3870	8264										
ZNF91	7644	broad.mit.edu	37	chr19	23543617	23543617	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atttgaagatcgattaaaagCtttgccacattcttcacatt	5	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:23543617C>T	ENST00000300619.7	-	4	2369	c.2164G>A	c.(2164-2166)Gct>Act	p.A722T	ZNF91_ENST00000397082.2_Missense_Mutation_p.A690T|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	722						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CGATTAAAAGCTTTGCCACAT	0.338													7	19					0	0	1	0	0	T	23543617	C	T	23543617	3	4	48	1	0	0	0	0	1	0	0	0	18241	797	28	3	1415	3	ZNF91	19	23543617	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	602993	23543617	35585366	3871	8265										
ZNF254	9534	broad.mit.edu	37	chr19	24309134	24309134	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaaaaagcaatactgagaaGatatggaaaatatggacatg	9	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:24309134G>T	ENST00000357002.4	+	4	447	c.332G>T	c.(331-333)aGa>aTa	p.R111I	ZNF254_ENST00000342944.6_Missense_Mutation_p.R26I	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	111					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATACTGAGAAGATATGGAAAA	0.343													7	40					5.18039e-06	5.75679e-06	1	1	0	T	24309134	G	T	24309134	3	4	48	1	0	0	0	0	1	0	0	0	17855	942	33	2	346	2	ZNF254	19	24309134	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	765517	24309134	34819849	3872	8266										
ZNF254	9534	broad.mit.edu	37	chr19	24310052	24310052	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcggcaaaggttttaatcGatcttcaaatcttactacac	6	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:24310052G>A	ENST00000357002.4	+	4	1365	c.1250G>A	c.(1249-1251)cGa>cAa	p.R417Q	ZNF254_ENST00000342944.6_Missense_Mutation_p.R332Q	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	417					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GGTTTTAATCGATCTTCAAAT	0.358													16	19					0	0	1	0	0	A	24310052	G	A	24310052	3	1	48	1	0	0	0	0	1	0	0	0	17855	1058	37	1	1264	1	ZNF254	19	24310052	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	918	24310052	34818931	3873	8267										
C19orf12	83636	broad.mit.edu	37	chr19	30193874	30193874	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcacctaacagccccccGacagccccccctagaaaaca	6	20	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:30193874G>A	ENST00000323670.9	-	3	310	c.171C>T	c.(169-171)gtC>gtT	p.V57V	C19orf12_ENST00000392278.2_Silent_p.V68V|C19orf12_ENST00000592153.1_Silent_p.V57V|C19orf12_ENST00000392275.1_5'UTR|C19orf12_ENST00000392276.1_5'UTR	NM_001256047.1|NM_031448.4	NP_001242976.1|NP_113636.2	Q9NSK7	CS012_HUMAN	chromosome 19 open reading frame 12	57						integral to membrane		p.V68V(1)				Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			ACAGCCCCCCGACAGCCCCCC	0.522													42	73					0	0	1	0	0	A	30193874	G	A	30193874	2	1	48	1	0	0	0	0	0	0	0	1	1921	1045	37	1		1	C19orf12	19	30193874	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5883822	30193874	28935109	3874	8268										
ZNF536	9745	broad.mit.edu	37	chr19	30934829	30934829	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtcccagatgagcgacatCgaggacgacgcccgcaagaa	12	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:30934829C>T	ENST00000355537.3	+	2	507	c.360C>T	c.(358-360)atC>atT	p.I120I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGAGCGACATCGAGGACGACG	0.637													19	39					0	0	1	0	0	T	30934829	C	T	30934829	2	4	48	1	0	0	0	0	0	0	0	1	18030	874	31	1		1	ZNF536	19	30934829	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	740955	30934829	28194154	3875	8269										
ZNF536	9745	broad.mit.edu	37	chr19	31025807	31025807	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccagcaaccagcgctgcttCgcgacagaagcctgggctcg	12	15	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:31025807C>T	ENST00000355537.3	+	3	2371	c.2224C>T	c.(2224-2226)Cgc>Tgc	p.R742C		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	742					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGCGCTGCTTCGCGACAGAAG	0.577													77	92					0	0	1	0	0	T	31025807	C	T	31025807	3	4	48	1	0	0	0	0	1	0	0	0	18030	884	31	1	2230	1	ZNF536	19	31025807	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	90978	31025807	28103176	3876	8270										
ZNF536	9745	broad.mit.edu	37	chr19	31038888	31038888	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtccgcactgtgactatgccGgcacgcagtcagcatcctta	10	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:31038888G>A	ENST00000355537.3	+	4	2509	c.2362G>A	c.(2362-2364)Ggc>Agc	p.G788S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	788					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGACTATGCCGGCACGCAGTC	0.507													24	53					0	0	1	0	0	A	31038888	G	A	31038888	3	1	48	1	0	0	0	0	1	0	0	0	18030	1116	39	1	2372	1	ZNF536	19	31038888	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13081	31038888	28090095	3877	8271										
ZNF536	9745	broad.mit.edu	37	chr19	31039523	31039523	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtgcaggacagcattgcAtggcacggctgcttgttttg	13	9	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:31039523A>G	ENST00000355537.3	+	4	3144	c.2997A>G	c.(2995-2997)gcA>gcG	p.A999A		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	999					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACAGCATTGCATGGCACGGCT	0.567													45	84					0	0	1	0	0	G	31039523	A	G	31039523	2	3	48	1	0	0	0	0	0	0	0	1	18030	204	8	4		4	ZNF536	19	31039523	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	635	31039523	28089460	3878	8272										
TSHZ3	57616	broad.mit.edu	37	chr19	31769642	31769642	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaagggttggagttcttctGaagtgcatcgttggtgtctg	15	5	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:31769642G>A	ENST00000240587.4	-	2	1384	c.1057C>T	c.(1057-1059)Cag>Tag	p.Q353*		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	353					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GAGTTCTTCTGAAGTGCATCG	0.562													15	181					0	0	1	0	0	A	31769642	G	A	31769642	4	1	48	1	0	0	0	0	0	1	0	0	16685	1299	45	3	2192	3	TSHZ3	19	31769642	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	730119	31769642	27359341	3879	8273										
ANKRD27	84079	broad.mit.edu	37	chr19	33134529	33134529	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttggtgtagagagcattCgctgagtcctaaaccacata	9	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:33134529C>T	ENST00000306065.4	-	6	692	c.534G>A	c.(532-534)gcG>gcA	p.A178A	ANKRD27_ENST00000587352.1_Silent_p.A178A	NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	178					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					AGAGAGCATTCGCTGAGTCCT	0.577													79	158					0	0	1	0	0	T	33134529	C	T	33134529	2	4	48	1	0	0	0	0	0	0	0	1	651	871	31	1		1	ANKRD27	19	33134529	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1364887	33134529	25994454	3880	8274										
RHPN2	85415	broad.mit.edu	37	chr19	33490569	33490569	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatgtggtcgtagagctggGacaggcacttctcctggtgg	16	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:33490569G>A	ENST00000254260.3	-	10	1183	c.1148C>T	c.(1147-1149)tCc>tTc	p.S383F	RHPN2_ENST00000400226.4_Missense_Mutation_p.S232F	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	383	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					GTAGAGCTGGGACAGGCACTT	0.597													4	64					0	0	1	0	0	A	33490569	G	A	33490569	3	1	48	1	0	0	0	0	1	0	0	0	13400	1174	41	3	936	3	RHPN2	19	33490569	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	356040	33490569	25638414	3881	8275										
CHST8	64377	broad.mit.edu	37	chr19	34263626	34263626	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggtgcgttttcccgagttCgtccagtacctgctggacgt	14	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:34263626C>T	ENST00000262622.3	+	4	1691	c.933C>T	c.(931-933)ttC>ttT	p.F311F	CHST8_ENST00000438847.2_Silent_p.F311F|CHST8_ENST00000434302.1_Silent_p.F311F	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	311					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					TTCCCGAGTTCGTCCAGTACC	0.652													21	35					0	0	1	0	0	T	34263626	C	T	34263626	2	4	48	1	0	0	0	0	0	0	0	1	3432	883	31	1		1	CHST8	19	34263626	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	773057	34263626	24865357	3882	8276										
KIAA0355	9710	broad.mit.edu	37	chr19	34832663	34832663	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacccttcacagtcagctcaGaattccagtaatacagtggc	8	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:34832663G>A	ENST00000299505.6	+	10	2697	c.1824G>A	c.(1822-1824)caG>caA	p.Q608Q		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	608										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					AGTCAGCTCAGAATTCCAGTA	0.448													33	50					0	0	1	0	0	A	34832663	G	A	34832663	2	1	48	1	0	0	0	0	0	0	0	1	8211	933	33	3		3	KIAA0355	19	34832663	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	569037	34832663	24296320	3883	8277										
ZNF181	339318	broad.mit.edu	37	chr19	35232056	35232056	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcctcaatcgccactggaGaattcatacaggagagaagc	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:35232056G>T	ENST00000392232.3	+	6	1070	c.902G>T	c.(901-903)aGa>aTa	p.R301I	ZNF181_ENST00000459757.1_Missense_Mutation_p.R256I|ZNF181_ENST00000492450.1_Missense_Mutation_p.R257I			Q2M3W8	ZN181_HUMAN	zinc finger protein 181	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CGCCACTGGAGAATTCATACA	0.448													63	78					1.48873e-21	2.05779e-21	1	1	0	T	35232056	G	T	35232056	3	4	48	1	0	0	0	0	1	0	0	0	17806	942	33	2	784	2	ZNF181	19	35232056	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	399393	35232056	23896927	3884	8278										
ZNF599	148103	broad.mit.edu	37	chr19	35251258	35251258	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcatcatgtttataactcaActtctcagggcatatctctt	4	10	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:35251258A>C	ENST00000329285.7	-	4	821	c.448T>G	c.(448-450)Ttg>Gtg	p.L150V		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TTATAACTCAACTTCTCAGGG	0.453													22	81					0	0	1	0	0	C	35251258	A	C	35251258	3	2	48	1	0	0	0	0	1	0	0	0	18085	40	2	4	1322	4	ZNF599	19	35251258	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	19202	35251258	23877725	3885	8279										
MAG	4099	broad.mit.edu	37	chr19	35786762	35786762	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgggggacctgggcctgcGaaactgcaccctcctgctca	12	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:35786762G>T	ENST00000361922.4	+	4	443	c.293G>T	c.(292-294)cGa>cTa	p.R98L	MAG_ENST00000537831.2_Missense_Mutation_p.R73L|MAG_ENST00000392213.3_Missense_Mutation_p.R98L|MAG_ENST00000597035.1_Intron	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	98	Ig-like V-type.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CTGGGCCTGCGAAACTGCACC	0.642													75	127					2.23399e-28	3.17216e-28	1	1	0	T	35786762	G	T	35786762	3	4	48	1	0	0	0	0	1	0	0	0	9207	1058	37	2	299	2	MAG	19	35786762	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	535504	35786762	23342221	3886	8280										
TMEM147	10430	broad.mit.edu	37	chr19	36038136	36038136	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtgtctacaaggcctttgTtatggagtgagttgggtggg	16	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:36038136T>C	ENST00000392204.2	+	5	726	c.398T>C	c.(397-399)gTt>gCt	p.V133A	TMEM147_ENST00000222284.5_Missense_Mutation_p.V182A|TMEM147_ENST00000392205.1_Missense_Mutation_p.V182A	NM_001242597.1	NP_001229526.1	Q9BVK8	TM147_HUMAN	transmembrane protein 147	182						endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			AAGGCCTTTGTTATGGAGTGA	0.527													4	79					0	0	1	0	0	C	36038136	T	C	36038136	3	2	48	1	0	0	0	0	1	0	0	0	16120	1725	60	4	567	4	TMEM147	19	36038136	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	251374	36038136	23090847	3887	8281										
HAUS5	23354	broad.mit.edu	37	chr19	36108227	36108227	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcaccctccgggcccagttCctgcagaacctcctgcttcc	8	19	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:36108227C>T	ENST00000203166.5	+	8	619	c.594C>T	c.(592-594)ttC>ttT	p.F198F	HAUS5_ENST00000379045.2_Silent_p.F198F	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	198					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						GGGCCCAGTTCCTGCAGAACC	0.632													30	51					0	0	1	0	0	T	36108227	C	T	36108227	2	4	48	1	0	0	0	0	0	0	0	1	7009	854	30	3		3	HAUS5	19	36108227	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	70091	36108227	23020756	3888	8282										
HAUS5	23354	broad.mit.edu	37	chr19	36110954	36110954	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcccatccatccaccagCtgcaccccgcgtccccaagg	6	22	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:36110954C>A	ENST00000203166.5	+	16	1472	c.1447C>A	c.(1447-1449)Ctg>Atg	p.L483M	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	483					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						CATCCACCAGCTGCACCCCGC	0.652													62	114					4.09171e-25	5.75624e-25	1	1	0	A	36110954	C	A	36110954	3	1	48	1	0	0	0	0	1	0	0	0	7009	796	28	5	1509	5	HAUS5	19	36110954	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2727	36110954	23018029	3889	8283										
ZBTB32	27033	broad.mit.edu	37	chr19	36205547	36205547	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatgtccctgccccccataAgactgcccagcccctatggc	7	19	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:36205547A>C	ENST00000392197.2	+	3	337	c.19A>C	c.(19-21)Aga>Cga	p.R7R	ZBTB32_ENST00000262630.3_Silent_p.R7R			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	7					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCCCCCCATAAGACTGCCCAG	0.582													66	148					0	0	1	0	0	C	36205547	A	C	36205547	2	2	48	1	0	0	0	0	0	0	0	1	17593	64	3	4		4	ZBTB32	19	36205547	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	94593	36205547	22923436	3890	8284										
ARHGAP33	115703	broad.mit.edu	37	chr19	36273380	36273380	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctacttccgagagcttccGaaccctctgctcacctacca	5	18	3	1	rs138321382	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:36273380G>A	ENST00000007510.4	+	13	1335	c.1191G>A	c.(1189-1191)ccG>ccA	p.P397P	ARHGAP33_ENST00000314737.5_Silent_p.P397P|ARHGAP33_ENST00000378944.5_Silent_p.P261P			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	397	Rho-GAP.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GAGAGCTTCCGAACCCTCTGC	0.607													28	37					0	0	1	0	0	A	36273380	G	A	36273380	2	1	48	1	0	0	0	0	0	0	0	1	879	1045	37	1		1	ARHGAP33	19	36273380	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	67833	36273380	22855603	3891	8285										
ZNF461	92283	broad.mit.edu	37	chr19	37130011	37130011	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacattcatgacattcataAggtttcttgccagaatgaat	6	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:37130011A>C	ENST00000588268.1	-	6	1463	c.1236T>G	c.(1234-1236)ccT>ccG	p.P412P	ZNF461_ENST00000360357.4_Silent_p.P389P|ZNF461_ENST00000540605.2_5'UTR	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GACATTCATAAGGTTTCTTGC	0.418													32	59					0	0	1	0	0	C	37130011	A	C	37130011	2	2	48	1	0	0	0	0	0	0	0	1	17981	59	3	4		4	ZNF461	19	37130011	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	856631	37130011	21998972	3892	8286										
ZNF567	163081	broad.mit.edu	37	chr19	37210849	37210849	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttcaccagaaggcaaatcTtactgtacatcagagaactc	6	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:37210849T>G	ENST00000585696.1	+	3	2360	c.1130T>G	c.(1129-1131)cTt>cGt	p.L377R	ZNF567_ENST00000360729.4_Missense_Mutation_p.L377R|ZNF567_ENST00000392163.2_Missense_Mutation_p.L377R|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000588311.1_Missense_Mutation_p.L377R|ZNF567_ENST00000536254.2_Missense_Mutation_p.L408R			Q8N184	ZN567_HUMAN	zinc finger protein 567	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAGGCAAATCTTACTGTACAT	0.423													24	35					0	0	1	0	0	G	37210849	T	G	37210849	3	3	48	1	0	0	0	0	1	0	0	0	18054	1609	56	4	1140	4	ZNF567	19	37210849	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	80838	37210849	21918134	3893	8287										
ZNF420	147923	broad.mit.edu	37	chr19	37581896	37581896	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acattttgtttgttgtttcaGaaattagtgatgttcaggga	10	3	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:37581896G>T	ENST00000337995.3	+	4	224		c.e4-1		ZNF420_ENST00000304239.7_Splice_Site	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTTGTTTCAGAAATTAGTGA	0.353													20	34					2.39187e-15	3.14903e-15	1	1	0	T	37581896	G	T	37581896	5	4	48	1	0	0	0	0	0	0	1	0	17953	956	33	2	15	2	ZNF420	19	37581896	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	371047	37581896	21547087	3894	8288										
ZNF585A	199704	broad.mit.edu	37	chr19	37644184	37644184	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctccggtatgaattCtctgatgcctgaagagggac	11	9	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:37644184C>A	ENST00000356958.4	-	5	875	c.617G>T	c.(616-618)aGa>aTa	p.R206I	ZNF585A_ENST00000292841.5_Missense_Mutation_p.R151I|ZNF585A_ENST00000392157.2_Missense_Mutation_p.R151I|ZNF585A_ENST00000355533.2_Missense_Mutation_p.R151I|ZNF585A_ENST00000588723.1_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTATGAATTCTCTGATGCCT	0.388													23	54					5.26018e-13	6.70247e-13	1	1	0	A	37644184	C	A	37644184	3	1	48	1	0	0	0	0	1	0	0	0	18073	913	32	2	1696	2	ZNF585A	19	37644184	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	62288	37644184	21484799	3895	8289										
ZNF793	390927	broad.mit.edu	37	chr19	38027836	38027836	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatatccagaggaaaagacgGcaagacatgcttttgaggcc	11	8	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:38027836G>A	ENST00000445217.1	+	4	311	c.276G>A	c.(274-276)cgG>cgA	p.R92R	ZNF793_ENST00000587143.1_Silent_p.R92R|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000542455.1_Silent_p.R92R|ZNF793_ENST00000589319.1_Silent_p.R92R			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAAAAGACGGCAAGACATGC	0.393													10	13					0	0	1	0	0	A	38027836	G	A	38027836	2	1	48	1	0	0	0	0	0	0	0	1	18213	1190	42	3		3	ZNF793	19	38027836	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	383652	38027836	21101147	3896	8290										
ZNF571	51276	broad.mit.edu	37	chr19	38056098	38056098	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttctctccggtatgaattCtttgatgttgaataagatta	8	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:38056098C>A	ENST00000328550.2	-	4	1331	c.1232G>T	c.(1231-1233)aGa>aTa	p.R411I	ZNF571-AS1_ENST00000586013.1_RNA|ZNF571_ENST00000358744.3_Missense_Mutation_p.R411I|ZNF571_ENST00000451802.2_Missense_Mutation_p.R411I|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571-AS1_ENST00000585578.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA|ZNF571-AS1_ENST00000589802.1_RNA|ZNF571_ENST00000593133.1_Missense_Mutation_p.R411I|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571_ENST00000590751.1_Intron|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571-AS1_ENST00000592392.1_RNA			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTATGAATTCTTTGATGTTG	0.373													13	17					7.93312e-07	8.98086e-07	1	1	0	A	38056098	C	A	38056098	3	1	48	1	0	0	0	0	1	0	0	0	18059	913	32	2	601	2	ZNF571	19	38056098	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	28262	38056098	21072885	3897	8291										
ZNF781	163115	broad.mit.edu	37	chr19	38160724	38160724	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctcaccagtatgaattCtttgatgtcgaataagatgt	8	6	2	3	rs138038465		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:38160724C>A	ENST00000358582.4	-	4	1074	c.326G>T	c.(325-327)aGa>aTa	p.R109I	ZFP30_ENST00000586732.1_Intron|ZNF781_ENST00000590008.1_Missense_Mutation_p.R109I	NM_152605.3	NP_689818.2	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						AGTATGAATTCTTTGATGTCG	0.373													30	61					1.68575e-08	1.99097e-08	1	1	0	A	38160724	C	A	38160724	3	1	48	1	0	0	0	0	1	0	0	0	18202	913	32	2	661	2	ZNF781	19	38160724	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	104626	38160724	20968259	3898	8292										
KCNK6	9424	broad.mit.edu	37	chr19	38817882	38817882	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaccttccgccacgtgtccGacctccacggcctcacggag	10	18	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:38817882G>A	ENST00000263372.3	+	3	888	c.781G>A	c.(781-783)Gac>Aac	p.D261N		NM_004823.1	NP_004814.1	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	261						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)	17	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	CCACGTGTCCGACCTCCACGG	0.657													19	56					0	0	1	0	0	A	38817882	G	A	38817882	3	1	48	1	0	0	0	0	1	0	0	0	8113	1058	37	1	791	1	KCNK6	19	38817882	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	657158	38817882	20311101	3899	8293										
RYR1	6261	broad.mit.edu	37	chr19	38985162	38985162	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaccatctcaccgtcctccGtggaagacaccatgagcctg	8	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:38985162G>A	ENST00000355481.4	+	39	6576	c.6445G>A	c.(6445-6447)Gtg>Atg	p.V2149M	RYR1_ENST00000360985.3_Missense_Mutation_p.V2149M|RYR1_ENST00000359596.3_Missense_Mutation_p.V2149M	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2149	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACCGTCCTCCGTGGAAGACAC	0.657													26	39					0	0	1	0	0	A	38985162	G	A	38985162	3	1	48	1	0	0	0	0	1	0	0	0	13819	1145	40	1	6599	1	RYR1	19	38985162	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	167280	38985162	20143821	3900	8294										
RYR1	6261	broad.mit.edu	37	chr19	38990408	38990408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaggccatccgcatctcCgaggaccctgcgagggatgg	15	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:38990408C>T	ENST00000355481.4	+	44	7292	c.7161C>T	c.(7159-7161)tcC>tcT	p.S2387S	RYR1_ENST00000360985.3_Silent_p.S2387S|RYR1_ENST00000359596.3_Silent_p.S2387S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2387	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCGCATCTCCGAGGACCCTG	0.706													9	21					0	0	1	0	0	T	38990408	C	T	38990408	2	4	48	1	0	0	0	0	0	0	0	1	13819	639	23	1		1	RYR1	19	38990408	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5246	38990408	20138575	3901	8295										
SIRT2	22933	broad.mit.edu	37	chr19	39384111	39384111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtcagctcgtccagcagacGctccttctggctgcccaggc	12	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:39384111G>A	ENST00000249396.7	-	4	470	c.169C>T	c.(169-171)Cgt>Tgt	p.R57C	SIRT2_ENST00000358931.5_Missense_Mutation_p.R57C|SIRT2_ENST00000392081.2_Missense_Mutation_p.R20C	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	57					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			TCCAGCAGACGCTCCTTCTGG	0.617													13	16					0	0	1	0	0	A	39384111	G	A	39384111	3	1	48	1	0	0	0	0	1	0	0	0	14392	1087	38	1	1052	1	SIRT2	19	39384111	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	393703	39384111	19744872	3902	8296										
FBXO27	126433	broad.mit.edu	37	chr19	39517572	39517572	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagcagagaatttatctaGaacagtctggttggcgtcta	10	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:39517572G>T	ENST00000292853.4	-	5	765	c.646C>A	c.(646-648)Cta>Ata	p.L216I	FBXO27_ENST00000509137.2_Missense_Mutation_p.L216I|FBXO27_ENST00000600828.1_Missense_Mutation_p.L215I	NM_178820.3	NP_849142.1	Q8NI29	FBX27_HUMAN	F-box protein 27	216	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|urinary_tract(2)	17	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			AATTTATCTAGAACAGTCTGG	0.557													52	122					9.40368e-32	1.3465e-31	1	1	0	T	39517572	G	T	39517572	3	4	48	1	0	0	0	0	1	0	0	0	5769	933	33	2	213	2	FBXO27	19	39517572	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	133461	39517572	19611411	3903	8297										
DYRK1B	9149	broad.mit.edu	37	chr19	40318227	40318227	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagggaccacatgtcaatggCcaggtcgtagggtgtgccca	14	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:40318227C>T	ENST00000593685.1	-	7	1345	c.877G>A	c.(877-879)Gcc>Acc	p.A293T	DYRK1B_ENST00000430012.2_Missense_Mutation_p.A293T|DYRK1B_ENST00000597639.1_Missense_Mutation_p.A293T|DYRK1B_ENST00000348817.3_Missense_Mutation_p.A293T|DYRK1B_ENST00000323039.5_Missense_Mutation_p.A293T			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	293	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			ATGTCAATGGCCAGGTCGTAG	0.592													20	62					0	0	1	0	0	T	40318227	C	T	40318227	3	4	48	1	0	0	0	0	1	0	0	0	4881	739	26	3	1032	3	DYRK1B	19	40318227	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	800655	40318227	18810756	3904	8298										
FCGBP	8857	broad.mit.edu	37	chr19	40363943	40363943	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatctccagctgcattcttcTcaagcacgatggaaaagtcc	8	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:40363943T>C	ENST00000221347.6	-	31	14706	c.14699A>G	c.(14698-14700)gAg>gGg	p.E4900G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4900	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCATTCTTCTCAAGCACGAT	0.587													31	53					0	0	1	0	0	C	40363943	T	C	40363943	3	2	48	1	0	0	0	0	1	0	0	0	5810	1551	54	4	1542	4	FCGBP	19	40363943	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	45716	40363943	18765040	3905	8299										
ZNF546	339327	broad.mit.edu	37	chr19	40514459	40514459	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaatgagggaagggacaagGaattggttcacaggtgagtg	17	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:40514459G>A	ENST00000347077.4	+	6	597	c.381G>A	c.(379-381)agG>agA	p.R127R	ZNF546_ENST00000600094.1_Silent_p.R101R|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	127	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGGGACAAGGAATTGGTTCA	0.463													29	52					0	0	1	0	0	A	40514459	G	A	40514459	2	1	48	1	0	0	0	0	0	0	0	1	18034	1165	41	3		3	ZNF546	19	40514459	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	150516	40514459	18614524	3906	8300										
ZNF780B	163131	broad.mit.edu	37	chr19	40542471	40542471	+	Translation_Start_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttataacatgtttgggtaAatttatttcaaaaatatcat	4	4	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:40542471A>C	ENST00000221355.6	-	0	552				ZNF780B_ENST00000434248.1_Missense_Mutation_p.L99V|ZNF780B_ENST00000598845.1_3'UTR			Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGTTTGGGTAAATTTATTTCA	0.313													6	8					0	0	1	0	0	C	40542471	A	C	40542471	1	2	48	1	0	0	0	0	0	0	0	0	18201	11	1	4		4	ZNF780B	19	40542471	Translation_Start_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	28012	40542471	18586512	3907	8301										
MAP3K10	4294	broad.mit.edu	37	chr19	40719431	40719431	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccggttgcagaggagttCgcggaggcagaggatggagg	19	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:40719431C>T	ENST00000253055.3	+	9	2133	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	615					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CAGAGGAGTTCGCGGAGGCAG	0.706													15	17					0	0	1	0	0	T	40719431	C	T	40719431	2	4	48	1	0	0	0	0	0	0	0	1	9293	883	31	1		1	MAP3K10	19	40719431	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	176960	40719431	18409552	3908	8302										
CYP2A7	1549	broad.mit.edu	37	chr19	41386003	41386003	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttacctgccccgtggaggTtgacgtgaactggaagattc	13	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:41386003T>C	ENST00000301146.4	-	4	1181	c.640A>G	c.(640-642)Acc>Gcc	p.T214A	CTC-490E21.12_ENST00000601627.1_Intron|CYP2A7_ENST00000291764.3_Missense_Mutation_p.T163A	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	214						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CCCGTGGAGGTTGACGTGAAC	0.572													37	70					0	0	1	0	0	C	41386003	T	C	41386003	3	2	48	1	0	0	0	0	1	0	0	0	4186	1725	60	4	868	4	CYP2A7	19	41386003	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	666572	41386003	17742980	3909	8303										
ATP5SL	55101	broad.mit.edu	37	chr19	41944166	41944166	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctccctttggagcaagtAatccctcagagcctccacat	6	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:41944166A>G	ENST00000221943.9	-	2	177	c.172T>C	c.(172-174)Tac>Cac	p.Y58H	ATP5SL_ENST00000592922.2_Missense_Mutation_p.Y58H|ATP5SL_ENST00000590641.2_Missense_Mutation_p.Y64H|ATP5SL_ENST00000589970.1_Missense_Mutation_p.Y58H|ATP5SL_ENST00000438807.3_Missense_Mutation_p.Y58H|ATP5SL_ENST00000417807.3_Missense_Mutation_p.Y64H|ATP5SL_ENST00000597457.1_Missense_Mutation_p.Y58H|ATP5SL_ENST00000595425.1_Missense_Mutation_p.Y58H|ATP5SL_ENST00000301183.11_Missense_Mutation_p.Y64H	NM_018035.2	NP_060505.2	Q9NW81	AT5SL_HUMAN	ATP5S-like	58										breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	11						TGGAGCAAGTAATCCCTCAGA	0.537													4	122					0	0	1	0	0	G	41944166	A	G	41944166	3	3	48	1	0	0	0	0	1	0	0	0	1162	362	13	4	621	4	ATP5SL	19	41944166	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	558163	41944166	17184817	3910	8304										
DMRTC2	63946	broad.mit.edu	37	chr19	42352862	42352862	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtgccctctgcccctgcaGaactcctgtgggcctctgct	10	17	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:42352862G>T	ENST00000269945.3	+	5	498		c.e5-1		DMRTC2_ENST00000596827.1_Splice_Site|DMRTC2_ENST00000602098.1_3'UTR	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2						cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						TGCCCCTGCAGAACTCCTGTG	0.622													64	119					1.25706e-45	1.82083e-45	1	1	0	T	42352862	G	T	42352862	5	4	48	1	0	0	0	0	0	0	1	0	4619	956	33	2	461	2	DMRTC2	19	42352862	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	408696	42352862	16776121	3911	8305										
ATP1A3	478	broad.mit.edu	37	chr19	42485761	42485761	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgcacttgagcagggcagActcagacgcatccccagcca	11	14	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:42485761A>G	ENST00000545399.1	-	11	1522	c.1369T>C	c.(1369-1371)Tct>Cct	p.S457P	ATP1A3_ENST00000543770.1_Missense_Mutation_p.S455P|ATP1A3_ENST00000302102.5_Missense_Mutation_p.S444P|ATP1A3_ENST00000602133.1_Missense_Mutation_p.S414P	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	444					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						AGCAGGGCAGACTCAGACGCA	0.572													18	32					0	0	1	0	0	G	42485761	A	G	42485761	3	3	48	1	0	0	0	0	1	0	0	0	1129	275	10	4	1763	4	ATP1A3	19	42485761	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	132899	42485761	16643222	3912	8306										
LIPE	3991	broad.mit.edu	37	chr19	42910525	42910525	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtcccccgcaaggcagattCgttcccctgttgagcctggt	11	14	0	2	rs150484479	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:42910525C>T	ENST00000244289.4	-	7	2429	c.2153G>A	c.(2152-2154)cGa>cAa	p.R718Q	LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	718					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				AAGGCAGATTCGTTCCCCTGT	0.647													13	27					0	0	1	0	0	T	42910525	C	T	42910525	3	4	48	1	0	0	0	0	1	0	0	0	8861	884	31	1	1093	1	LIPE	19	42910525	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	424764	42910525	16218458	3913	8307										
PSG6	5675	broad.mit.edu	37	chr19	43411078	43411078	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgggatccacttaccagaGactttgactatcatggattt	9	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:43411078G>T	ENST00000187910.2	-	5	1301	c.1236C>A	c.(1234-1236)gtC>gtA	p.V412V	PSG6_ENST00000402603.4_Silent_p.V319V|PSG6_ENST00000292125.2_Silent_p.V412V	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				ACTTACCAGAGACTTTGACTA	0.443													102	197					3.78979e-47	5.49226e-47	1	1	0	T	43411078	G	T	43411078	2	4	48	1	0	0	0	0	0	0	0	1	12707	929	33	2		2	PSG6	19	43411078	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	500553	43411078	15717905	3914	8308										
ZNF404	342908	broad.mit.edu	37	chr19	44377739	44377739	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatagggtttcataccagtAtgaattatctgatgctgaat	8	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:44377739A>G	ENST00000587539.1	-	3	626	c.627T>C	c.(625-627)caT>caC	p.H209H	ZNF404_ENST00000324394.6_Silent_p.H207H	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				TCATACCAGTATGAATTATCT	0.388													24	48					0	0	1	0	0	G	44377739	A	G	44377739	2	3	48	1	0	0	0	0	0	0	0	1	17942	446	16	4		4	ZNF404	19	44377739	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	966661	44377739	14751244	3915	8309										
ZNF227	7770	broad.mit.edu	37	chr19	44740349	44740349	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagggcttcagttggagatCaaatcttcatgcacatcaaa	9	8	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:44740349C>A	ENST00000313040.7	+	6	1971	c.1766C>A	c.(1765-1767)tCa>tAa	p.S589*	ZNF227_ENST00000391961.2_Nonsense_Mutation_p.S538*|ZNF227_ENST00000589005.1_Nonsense_Mutation_p.S538*|ZNF235_ENST00000589799.1_3'UTR	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				AGTTGGAGATCAAATCTTCAT	0.388													33	35					4.74835e-14	6.14782e-14	1	1	0	A	44740349	C	A	44740349	4	1	48	1	0	0	0	0	0	1	0	0	17838	838	29	2	1780	2	ZNF227	19	44740349	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	362610	44740349	14388634	3916	8310										
ZNF233	353355	broad.mit.edu	37	chr19	44777266	44777266	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaggagaatctagtcaggtCtctgaagatgagaactatgt	11	6	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:44777266C>A	ENST00000391958.2	+	5	580	c.453C>A	c.(451-453)gtC>gtA	p.V151V	ZNF233_ENST00000592581.1_3'UTR|ZNF233_ENST00000334152.1_Intron|ZNF235_ENST00000589799.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				CTAGTCAGGTCTCTGAAGATG	0.418													24	38					1.85244e-09	2.22951e-09	1	1	0	A	44777266	C	A	44777266	2	1	48	1	0	0	0	0	0	0	0	1	17843	900	32	2		2	ZNF233	19	44777266	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	36917	44777266	14351717	3917	8311										
ZNF285	26974	broad.mit.edu	37	chr19	44891906	44891906	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctcttccatgtaaattccCttatatcttccctgagagtt	4	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:44891906C>A	ENST00000330997.4	-	4	565	c.501G>T	c.(499-501)aaG>aaT	p.K167N	ZNF285_ENST00000591679.1_Missense_Mutation_p.K174N|CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000544719.2_Missense_Mutation_p.K167N	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TGTAAATTCCCTTATATCTTC	0.463													27	55					3.99451e-17	5.34789e-17	1	1	0	A	44891906	C	A	44891906	3	1	48	1	0	0	0	0	1	0	0	0	17879	680	24	5	1275	5	ZNF285	19	44891906	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	114640	44891906	14237077	3918	8312										
ZNF229	7772	broad.mit.edu	37	chr19	44933963	44933963	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacgtatgtgcgtgttctgTctgacgccccgaccacgctc	10	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:44933963T>C	ENST00000291187.4	-	6	1297	c.975A>G	c.(973-975)agA>agG	p.R325R	ZNF229_ENST00000588931.1_Silent_p.R331R|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GCGTGTTCTGTCTGACGCCCC	0.507													5	64					0	0	1	0	0	C	44933963	T	C	44933963	2	2	48	1	0	0	0	0	0	0	0	1	17839	1664	58	4		4	ZNF229	19	44933963	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	42057	44933963	14195020	3919	8313										
ZNF180	7733	broad.mit.edu	37	chr19	44981496	44981496	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctccagtatgagttCtctgatgggaaacaaggtgc	11	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:44981496C>A	ENST00000221327.4	-	5	1483	c.1202G>T	c.(1201-1203)aGa>aTa	p.R401I	ZNF180_ENST00000391956.4_Missense_Mutation_p.R376I|ZNF180_ENST00000592529.1_Missense_Mutation_p.R374I	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R401I(2)		NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				AGTATGAGTTCTCTGATGGGA	0.448													17	40					2.94398e-08	3.45884e-08	1	1	0	A	44981496	C	A	44981496	3	1	48	1	0	0	0	0	1	0	0	0	17805	913	32	2	880	2	ZNF180	19	44981496	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	47533	44981496	14147487	3920	8314										
KLC3	147700	broad.mit.edu	37	chr19	45853653	45853653	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcggaagagctgtacaaaGaaatcctccacaaggaggac	11	9	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:45853653G>T	ENST00000470402.1	+	8	1340	c.1240G>T	c.(1240-1242)Gaa>Taa	p.E414*	KLC3_ENST00000391946.2_Nonsense_Mutation_p.E400*|KLC3_ENST00000585434.1_Nonsense_Mutation_p.E399*|ERCC2_ENST00000391945.4_3'UTR			Q6P597	KLC3_HUMAN	kinesin light chain 3	400						cytoplasm|kinesin complex|microtubule	microtubule motor activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GCTGTACAAAGAAATCCTCCA	0.562													20	57					1.33834e-09	1.61283e-09	1	1	0	T	45853653	G	T	45853653	4	4	48	1	0	0	0	0	0	1	0	0	8377	943	33	2	1228	2	KLC3	19	45853653	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	872157	45853653	13275330	3921	8315										
PRKD2	25865	broad.mit.edu	37	chr19	47204175	47204175	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgagggcgctcttgtcagcCtcgctgaaatcggtggcctc	13	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:47204175C>T	ENST00000433867.1	-	8	1479	c.1002G>A	c.(1000-1002)gaG>gaA	p.E334E	PRKD2_ENST00000291281.4_Silent_p.E334E|PRKD2_ENST00000601806.1_Silent_p.E177E|PRKD2_ENST00000600194.1_Silent_p.E177E|PRKD2_ENST00000595515.1_Silent_p.E334E	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	334					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TCTTGTCAGCCTCGCTGAAAT	0.627													4	42					0	0	1	0	0	T	47204175	C	T	47204175	2	4	48	1	0	0	0	0	0	0	0	1	12570	680	24	3		3	PRKD2	19	47204175	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1350522	47204175	11924808	3922	8316										
STRN4	29888	broad.mit.edu	37	chr19	47223872	47223872	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgggcatcatacgaagaccTtggccagggcatcagcgcca	13	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:47223872T>G	ENST00000391910.3	-	17	2720	c.2270A>C	c.(2269-2271)aAg>aCg	p.K757T	STRN4_ENST00000539396.1_Missense_Mutation_p.K631T|STRN4_ENST00000263280.6_Missense_Mutation_p.K750T			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	750						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		TACGAAGACCTTGGCCAGGGC	0.677													18	26					0	0	1	0	0	G	47223872	T	G	47223872	3	3	48	1	0	0	0	0	1	0	0	0	15386	1609	56	4	16	4	STRN4	19	47223872	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	19697	47223872	11905111	3923	8317										
FKRP	79147	broad.mit.edu	37	chr19	47258711	47258711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccagacttcggccccatgCggctcacccgctgccaggct	10	20	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:47258711C>T	ENST00000318584.5	+	4	301	c.4C>T	c.(4-6)Cgg>Tgg	p.R2W	FKRP_ENST00000600646.1_Intron|FKRP_ENST00000391909.3_Missense_Mutation_p.R2W	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	2						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		CGGCCCCATGCGGCTCACCCG	0.657													8	16					0	0	1	0	0	T	47258711	C	T	47258711	3	4	48	1	0	0	0	0	1	0	0	0	5949	759	27	1	6	1	FKRP	19	47258711	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	34839	47258711	11870272	3924	8318										
ARHGAP35	2909	broad.mit.edu	37	chr19	47424921	47424921	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccatcttacagcctgtttCgagaagacacatcactgcct	7	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:47424921C>T	ENST00000404338.3	+	1	2989	c.2989C>T	c.(2989-2991)Cga>Tga	p.R997*		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	997					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CAGCCTGTTTCGAGAAGACAC	0.478													32	39					0	0	1	0	0	T	47424921	C	T	47424921	4	4	48	1	0	0	0	0	0	1	0	0	6835	876	31	1	2991	1	ARHGAP35	19	47424921	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	166210	47424921	11704062	3925	8319										
SULT2A1	6822	broad.mit.edu	37	chr19	48378009	48378009	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcatgctctgaaaggagctgTtcttgagaattaagttcagt	10	6	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:48378009T>C	ENST00000222002.3	-	5	789	c.650A>G	c.(649-651)aAc>aGc	p.N217S		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	217					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		AAAGGAGCTGTTCTTGAGAAT	0.378													11	40					0	0	1	0	0	C	48378009	T	C	48378009	3	2	48	1	0	0	0	0	1	0	0	0	15436	1725	60	4	215	4	SULT2A1	19	48378009	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	953088	48378009	10750974	3926	8320										
SULT2A1	6822	broad.mit.edu	37	chr19	48385443	48385443	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accagacaccaaaacatctcTgggatttctcatgagataaa	6	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:48385443T>C	ENST00000222002.3	-	3	509	c.370A>G	c.(370-372)Aga>Gga	p.R124G		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	124					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		AAAACATCTCTGGGATTTCTC	0.328													9	65					0	0	1	0	0	C	48385443	T	C	48385443	3	2	48	1	0	0	0	0	1	0	0	0	15436	1588	55	4	503	4	SULT2A1	19	48385443	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7434	48385443	10743540	3927	8321										
ELSPBP1	64100	broad.mit.edu	37	chr19	48525433	48525433	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctgcttcctaggaatttCcgcgttggtccctggctttc	9	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:48525433C>T	ENST00000339841.2	+	6	699	c.521C>T	c.(520-522)tCc>tTc	p.S174F	ELSPBP1_ENST00000597519.1_Missense_Mutation_p.S26F	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	174					single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		CTAGGAATTTCCGCGTTGGTC	0.453													31	64					0	0	1	0	0	T	48525433	C	T	48525433	3	4	48	1	0	0	0	0	1	0	0	0	5111	855	30	3	539	3	ELSPBP1	19	48525433	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	139990	48525433	10603550	3928	8322										
CCDC114	93233	broad.mit.edu	37	chr19	48800598	48800598	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagccacggtctctgctagTcttgtggctcaaaatggacc	11	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:48800598T>C	ENST00000315396.7	-	14	2330	c.1648A>G	c.(1648-1650)Act>Gct	p.T550A		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	550										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TCTCTGCTAGTCTTGTGGCTC	0.647													7	92					0	0	1	0	0	C	48800598	T	C	48800598	3	2	48	1	0	0	0	0	1	0	0	0	2769	1667	58	4	368	4	CCDC114	19	48800598	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	275165	48800598	10328385	3929	8323										
CCDC114	93233	broad.mit.edu	37	chr19	48806990	48806990	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagggcgtcctcgtagcaaAgcaccagcctctcctgggag	12	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:48806990A>G	ENST00000315396.7	-	8	1476	c.794T>C	c.(793-795)cTt>cCt	p.L265P		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	265										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CTCGTAGCAAAGCACCAGCCT	0.627													40	70					0	0	1	0	0	G	48806990	A	G	48806990	3	3	48	1	0	0	0	0	1	0	0	0	2769	72	3	4	1246	4	CCDC114	19	48806990	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6392	48806990	10321993	3930	8324										
ALDH16A1	126133	broad.mit.edu	37	chr19	49963000	49963000	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtgactgggcgggctgttCgagaggttcgagacggggac	20	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:49963000C>T	ENST00000293350.4	+	4	557	c.394C>T	c.(394-396)Cga>Tga	p.R132*	ALDH16A1_ENST00000455361.2_Nonsense_Mutation_p.R132*|ALDH16A1_ENST00000433981.2_5'UTR|ALDH16A1_ENST00000540132.1_Intron	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	132							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GCGGGCTGTTCGAGAGGTTCG	0.642													25	47					0	0	1	0	0	T	49963000	C	T	49963000	4	4	48	1	0	0	0	0	0	1	0	0	485	876	31	1	408	1	ALDH16A1	19	49963000	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1156010	49963000	9165983	3931	8325										
TSKS	60385	broad.mit.edu	37	chr19	50251695	50251695	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaagctggtgatggagtctTtggcgcggaccaatccactg	13	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:50251695T>C	ENST00000246801.3	-	3	513	c.431A>G	c.(430-432)aAa>aGa	p.K144R		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	144							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GATGGAGTCTTTGGCGCGGAC	0.562													12	45					0	0	1	0	0	C	50251695	T	C	50251695	3	2	48	1	0	0	0	0	1	0	0	0	16686	1841	64	4	1383	4	TSKS	19	50251695	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	288695	50251695	8877288	3932	8326										
NUP62	23636	broad.mit.edu	37	chr19	50412779	50412779	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgttgctcaagttgagctTtgaagcaccgatccccaaag	10	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:50412779T>G	ENST00000596217.1	-	2	2173	c.286A>C	c.(286-288)Aag>Cag	p.K96Q	CTC-326K19.6_ENST00000451973.1_3'UTR|NUP62_ENST00000352066.3_Missense_Mutation_p.K96Q|IL4I1_ENST00000341114.3_Intron|NUP62_ENST00000413454.1_Missense_Mutation_p.K96Q|IL4I1_ENST00000595948.1_Intron|NUP62_ENST00000597723.1_Missense_Mutation_p.K96Q|NUP62_ENST00000597029.1_Missense_Mutation_p.K96Q|NUP62_ENST00000422090.2_Missense_Mutation_p.K96Q			P37198	NUP62_HUMAN	nucleoporin 62kDa	96	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|stomach(1)|urinary_tract(2)	19		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AAGTTGAGCTTTGAAGCACCG	0.572													61	90					0	0	1	0	0	G	50412779	T	G	50412779	3	3	48	1	0	0	0	0	1	0	0	0	10815	1850	64	4	1286	4	NUP62	19	50412779	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	161084	50412779	8716204	3933	8327										
MYBPC2	4606	broad.mit.edu	37	chr19	50946777	50946777	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttgagaacgttggtaagaAgcgaattcttaccatcaaca	9	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:50946777A>C	ENST00000357701.5	+	10	980	c.929A>C	c.(928-930)aAg>aCg	p.K310T		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	310	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GTTGGTAAGAAGCGAATTCTT	0.498													10	16					0	0	1	0	0	C	50946777	A	C	50946777	3	2	48	1	0	0	0	0	1	0	0	0	10059	72	3	4	967	4	MYBPC2	19	50946777	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	533998	50946777	8182206	3934	8328										
SHANK1	50944	broad.mit.edu	37	chr19	51205732	51205732	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccctgggtacctttgatcTtctcgcccttgctcagggag	10	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:51205732T>G	ENST00000293441.1	-	11	1757	c.1739A>C	c.(1738-1740)aAg>aCg	p.K580T	SHANK1_ENST00000359082.3_Missense_Mutation_p.K580T|SHANK1_ENST00000391814.1_Missense_Mutation_p.K580T	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	580	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACCTTTGATCTTCTCGCCCTT	0.627													4	25					0	0	1	0	0	G	51205732	T	G	51205732	3	3	48	1	0	0	0	0	1	0	0	0	14318	1609	56	4	4798	4	SHANK1	19	51205732	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	258955	51205732	7923251	3935	8329										
SHANK1	50944	broad.mit.edu	37	chr19	51218983	51218983	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtaaactcgggtcttgtatCggaactgaggtcaagggtag	14	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:51218983C>T	ENST00000293441.1	-	3	482	c.464G>A	c.(463-465)cGa>cAa	p.R155Q	SHANK1_ENST00000359082.3_Missense_Mutation_p.R155Q|SHANK1_ENST00000391814.1_Missense_Mutation_p.R155Q	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	155					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGTCTTGTATCGGAACTGAGG	0.532													44	79					0	0	1	0	0	T	51218983	C	T	51218983	3	4	48	1	0	0	0	0	1	0	0	0	14318	884	31	1	6105	1	SHANK1	19	51218983	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13251	51218983	7910000	3936	8330										
GPR32	2854	broad.mit.edu	37	chr19	51274539	51274539	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgctgggcttcctggggCccttagcaatcataggcacc	11	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:51274539C>T	ENST00000270590.4	+	1	819	c.682C>T	c.(682-684)Ccc>Tcc	p.P228S		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	228						integral to plasma membrane	N-formyl peptide receptor activity	p.P228S(2)		breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTTCCTGGGGCCCTTAGCAAT	0.597													25	50					0	0	1	0	0	T	51274539	C	T	51274539	3	4	48	1	0	0	0	0	1	0	0	0	6727	739	26	3	684	3	GPR32	19	51274539	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	55556	51274539	7854444	3937	8331										
LIM2	3982	broad.mit.edu	37	chr19	51883766	51883766	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcccccagtacctgcgaaGaacgtcatgagcactgccac	9	15	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:51883766G>T	ENST00000221973.3	-	4	621	c.579C>A	c.(577-579)ttC>ttA	p.F193L	LIM2_ENST00000596399.1_Missense_Mutation_p.F151L	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	151					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		TACCTGCGAAGAACGTCATGA	0.612													9	309					3.09899e-07	3.54467e-07	1	1	0	T	51883766	G	T	51883766	3	4	48	1	0	0	0	0	1	0	0	0	8834	933	33	2	76	2	LIM2	19	51883766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	609227	51883766	7245217	3938	8332										
CEACAM18	729767	broad.mit.edu	37	chr19	51986322	51986322	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgatgatttcaacggcaTtgtgacagctgagatcggct	11	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:51986322T>C	ENST00000396477.4	+	4	746	c.725T>C	c.(724-726)aTt>aCt	p.I242T	CEACAM18_ENST00000451626.1_Missense_Mutation_p.I303T	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	303						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TTCAACGGCATTGTGACAGCT	0.537													24	175					0	0	1	0	0	C	51986322	T	C	51986322	3	2	48	1	0	0	0	0	1	0	0	0	3211	1493	52	4	926	4	CEACAM18	19	51986322	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	102556	51986322	7142661	3939	8333										
HAS1	3036	broad.mit.edu	37	chr19	52216986	52216986	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatggtgactagcgccagGaacttggcaggcaggaggcc	15	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52216986G>A	ENST00000540069.2	-	5	1488	c.1428C>T	c.(1426-1428)ttC>ttT	p.F476F	HAS1_ENST00000222115.1_Silent_p.F477F|HAS1_ENST00000601714.1_Silent_p.F484F			Q92839	HAS1_HUMAN	hyaluronan synthase 1	477					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CTAGCGCCAGGAACTTGGCAG	0.692													8	14					0	0	1	0	0	A	52216986	G	A	52216986	2	1	48	1	0	0	0	0	0	0	0	1	7001	1165	41	3		3	HAS1	19	52216986	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	230664	52216986	6911997	3940	8334										
FPR2	2358	broad.mit.edu	37	chr19	52271959	52271959	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgaatatgaagaagtgtcCtatgagtctgctggctacac	10	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52271959C>A	ENST00000598776.1	+	2	820	c.48C>A	c.(46-48)tcC>tcA	p.S16S	FPR2_ENST00000340023.6_Silent_p.S16S|FPR2_ENST00000598953.1_Silent_p.S16S	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	16					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						AAGAAGTGTCCTATGAGTCTG	0.517													24	50					4.4004e-07	5.01286e-07	1	1	0	A	52271959	C	A	52271959	2	1	48	1	0	0	0	0	0	0	0	1	6072	668	24	5		5	FPR2	19	52271959	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	54973	52271959	6857024	3941	8335										
FPR3	2359	broad.mit.edu	37	chr19	52327920	52327920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctctacgtctttatgggtCgtaacttccaagaaagactg	8	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52327920C>T	ENST00000339223.4	+	2	1098	c.919C>T	c.(919-921)Cgt>Tgt	p.R307C	FPR3_ENST00000595991.1_Missense_Mutation_p.R307C	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	307					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						CTTTATGGGTCGTAACTTCCA	0.473													33	61					0	0	1	0	0	T	52327920	C	T	52327920	3	4	48	1	0	0	0	0	1	0	0	0	6073	884	31	1	921	1	FPR3	19	52327920	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	55961	52327920	6801063	3942	8336										
ZNF614	80110	broad.mit.edu	37	chr19	52519497	52519497	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgcattcatagggtttttCtcctgtatgagttcgctgat	9	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52519497C>A	ENST00000270649.6	-	5	1898	c.1354G>T	c.(1354-1356)Gaa>Taa	p.E452*	ZNF614_ENST00000356322.6_Intron	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TAGGGTTTTTCTCCTGTATGA	0.403													43	75					2.19962e-31	3.1472e-31	1	1	0	A	52519497	C	A	52519497	4	1	48	1	0	0	0	0	0	1	0	0	18095	922	32	2	407	2	ZNF614	19	52519497	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	191577	52519497	6609486	3943	8337										
ZNF616	90317	broad.mit.edu	37	chr19	52619047	52619047	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttctcgccggtatgaattCtccaatgcactgcaagatgt	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52619047C>A	ENST00000600228.1	-	4	1631	c.1370G>T	c.(1369-1371)aGa>aTa	p.R457I	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GGTATGAATTCTCCAATGCAC	0.403													37	60					2.38352e-08	2.80976e-08	1	1	0	A	52619047	C	A	52619047	3	1	48	1	0	0	0	0	1	0	0	0	18097	913	32	2	979	2	ZNF616	19	52619047	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	99550	52619047	6509936	3944	8338										
ZNF836	162962	broad.mit.edu	37	chr19	52660432	52660432	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaactgttattaactgtcttCtcagattggttacactcata	6	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52660432C>A	ENST00000322146.8	-	5	1025	c.504G>T	c.(502-504)gaG>gaT	p.E168D	CTC-471J1.8_ENST00000594362.1_RNA|ZNF836_ENST00000597252.1_Missense_Mutation_p.E168D	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TAACTGTCTTCTCAGATTGGT	0.343													3	9					0.004672	0.00483628	1	1	0	A	52660432	C	A	52660432	3	1	48	1	0	0	0	0	1	0	0	0	18233	912	32	2	2308	2	ZNF836	19	52660432	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	41385	52660432	6468551	3945	8339										
PPP2R1A	5518	broad.mit.edu	37	chr19	52705261	52705261	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttggggttgaaaggacccGaagtgagcttctgcctttcc	12	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52705261G>A	ENST00000322088.6	+	2	201	c.143G>A	c.(142-144)cGa>cAa	p.R48Q	PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.E27K|PPP2R1A_ENST00000473455.2_3'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	48	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GAAAGGACCCGAAGTGAGCTT	0.512			Mis		clear cell ovarian carcinoma								16	22					0	0	1	0	0	A	52705261	G	A	52705261	3	1	48	1	0	0	0	0	1	0	0	0	12430	1058	37	1	149	1	PPP2R1A	19	52705261	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	44829	52705261	6423722	3946	8340										
ZNF528	84436	broad.mit.edu	37	chr19	52918955	52918955	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctttcgaagcagttcaaagCttgcacaacatcaaagaatt	6	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:52918955C>A	ENST00000360465.3	+	7	1276	c.850C>A	c.(850-852)Ctt>Att	p.L284I	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		CAGTTCAAAGCTTGCACAACA	0.378													26	57					1.1804e-14	1.54286e-14	1	1	0	A	52918955	C	A	52918955	3	1	48	1	0	0	0	0	1	0	0	0	18025	797	28	5	864	5	ZNF528	19	52918955	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	213694	52918955	6210028	3947	8341										
ZNF808	388558	broad.mit.edu	37	chr19	53057257	53057257	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acacctttcacgccatcaaaGacttcatactggagtgaaac	6	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53057257G>T	ENST00000359798.4	+	5	1268	c.1088G>T	c.(1087-1089)aGa>aTa	p.R363I		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R363T(1)		endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CGCCATCAAAGACTTCATACT	0.383													6	96					0.00198382	0.00207034	1	1	0	T	53057257	G	T	53057257	3	4	48	1	0	0	0	0	1	0	0	0	18220	942	33	2	1098	2	ZNF808	19	53057257	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	138302	53057257	6071726	3948	8342										
ZNF28	7576	broad.mit.edu	37	chr19	53303889	53303889	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtttctctccagtatgaatCctcttatgtctttcaagatg	7	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53303889C>T	ENST00000438150.2	-	2	1943	c.1050G>A	c.(1048-1050)agG>agA	p.R350R	ZNF28_ENST00000414252.2_Silent_p.R350R|ZNF28_ENST00000457749.2_Silent_p.R403R|ZNF28_ENST00000360272.4_Silent_p.R350R			P17035	ZNF28_HUMAN	zinc finger protein 28	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		CAGTATGAATCCTCTTATGTC	0.373													41	83					0	0	1	0	0	T	53303889	C	T	53303889	2	4	48	1	0	0	0	0	0	0	0	1	17870	854	30	3		3	ZNF28	19	53303889	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	246632	53303889	5825094	3949	8343										
ZNF160	90338	broad.mit.edu	37	chr19	53578315	53578315	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagtcatcctcacccagaGaaacaaggttccagtagttc	8	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53578315G>A	ENST00000601421.1	-	1	905	c.29C>T	c.(28-30)tCt>tTt	p.S10F	ZNF160_ENST00000599056.1_Missense_Mutation_p.S46F|ZNF160_ENST00000429604.1_Missense_Mutation_p.S46F|ZNF160_ENST00000355147.5_Missense_Mutation_p.S46F|ZNF160_ENST00000418871.1_Missense_Mutation_p.S46F			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	46	KRAB.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		CTCACCCAGAGAAACAAGGTT	0.483													42	72					0	0	1	0	0	A	53578315	G	A	53578315	3	1	48	1	0	0	0	0	1	0	0	0	17796	942	33	3	2331	3	ZNF160	19	53578315	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	274426	53578315	5550668	3950	8344										
ZNF347	84671	broad.mit.edu	37	chr19	53644730	53644730	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtaaggcttttctccggtgtGaattaccagatgaatagcta	10	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53644730G>T	ENST00000452676.2	-	5	1780	c.1354C>A	c.(1354-1356)Cac>Aac	p.H452N	ZNF347_ENST00000601469.2_Missense_Mutation_p.H452N|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000334197.7_Missense_Mutation_p.H451N	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	451					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		TCTCCGGTGTGAATTACCAGA	0.438													46	74					1.23713e-20	1.6975e-20	1	1	0	T	53644730	G	T	53644730	3	4	48	1	0	0	0	0	1	0	0	0	17917	1290	45	2	1172	2	ZNF347	19	53644730	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	66415	53644730	5484253	3951	8345										
VN1R2	317701	broad.mit.edu	37	chr19	53762110	53762110	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acattttgacaattattttgGatgcaaatttcttttgtatg	6	4	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53762110G>A	ENST00000341702.3	+	1	566	c.482G>A	c.(481-483)gGa>gAa	p.G161E		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	161					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity	p.G161E(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		AATTATTTTGGATGCAAATTT	0.458													18	33					0	0	1	0	0	A	53762110	G	A	53762110	3	1	48	1	0	0	0	0	1	0	0	0	17238	1174	41	3	484	3	VN1R2	19	53762110	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	117380	53762110	5366873	3952	8346										
VN1R2	317701	broad.mit.edu	37	chr19	53762646	53762646	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacctacgtttatttagctCtcttcgataattccagttgg	6	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53762646C>A	ENST00000341702.3	+	1	1102	c.1018C>A	c.(1018-1020)Ctc>Atc	p.L340I	VN1R2_ENST00000598458.1_Intron	NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	340					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		TTATTTAGCTCTCTTCGATAA	0.463													51	98					6.08268e-21	8.37076e-21	1	1	0	A	53762646	C	A	53762646	3	1	48	1	0	0	0	0	1	0	0	0	17238	913	32	2	1020	2	VN1R2	19	53762646	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	536	53762646	5366337	3953	8347										
VN1R4	317703	broad.mit.edu	37	chr19	53770013	53770013	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgaggttaggagatcttgTcatcttttccaggcaaaaca	10	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53770013T>C	ENST00000311170.4	-	1	959	c.906A>G	c.(904-906)tgA>tgG	p.*302W		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	0					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GGAGATCTTGTCATCTTTTCC	0.388										HNSCC(26;0.072)			21	37					0	0	1	0	0	C	53770013	T	C	53770013	4	2	48	1	0	0	0	0	0	0	0	0	17239	1682	58	4	2	4	VN1R4	19	53770013	Nonstop_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	7367	53770013	5358970	3954	8348										
VN1R4	317703	broad.mit.edu	37	chr19	53770552	53770552	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagccaacatgcttgggggCtttctctttaagttttgccc	9	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53770552C>A	ENST00000311170.4	-	1	420	c.367G>T	c.(367-369)Gcc>Tcc	p.A123S		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	123					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		TGCTTGGGGGCTTTCTCTTTA	0.507										HNSCC(26;0.072)			11	51					0.00136819	0.00143372	1	1	0	A	53770552	C	A	53770552	3	1	48	1	0	0	0	0	1	0	0	0	17239	797	28	5	541	5	VN1R4	19	53770552	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	539	53770552	5358431	3955	8349										
VN1R4	317703	broad.mit.edu	37	chr19	53770689	53770689	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaacaagtttgcacccaagaGcattgagaaaatatctaacc	6	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53770689G>T	ENST00000311170.4	-	1	283	c.230C>A	c.(229-231)gCt>gAt	p.A77D		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	77					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GCACCCAAGAGCATTGAGAAA	0.488										HNSCC(26;0.072)			4	58					0.150653	0.151842	1	1	0	T	53770689	G	T	53770689	3	4	48	1	0	0	0	0	1	0	0	0	17239	971	34	5	678	5	VN1R4	19	53770689	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	137	53770689	5358294	3956	8350										
ZNF765	91661	broad.mit.edu	37	chr19	53911394	53911394	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaatgactatgggaataatTtcctgaattcttcattattc	5	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53911394T>G	ENST00000396408.3	+	4	703	c.586T>G	c.(586-588)Ttc>Gtc	p.F196V	ZNF765_ENST00000594030.1_Intron	NM_001040185.1	NP_001035275.1	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(3)	4				GBM - Glioblastoma multiforme(134;0.00379)		TGGGAATAATTTCCTGAATTC	0.373													9	71					0	0	1	0	0	G	53911394	T	G	53911394	3	3	48	1	0	0	0	0	1	0	0	0	18188	1841	64	4	596	4	ZNF765	19	53911394	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	140705	53911394	5217589	3957	8351										
ZNF813	126017	broad.mit.edu	37	chr19	53989942	53989942	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcaggaggagtggaaatgCctggaccctgctcagaggac	14	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:53989942C>A	ENST00000396403.4	+	3	200	c.72C>A	c.(70-72)tgC>tgA	p.C24*	ZNF813_ENST00000396421.4_Nonsense_Mutation_p.C24*	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AGTGGAAATGCCTGGACCCTG	0.473													32	109					9.39024e-22	1.29924e-21	1	1	0	A	53989942	C	A	53989942	4	1	48	1	0	0	0	0	0	1	0	0	18222	747	26	5	78	5	ZNF813	19	53989942	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	78548	53989942	5139041	3958	8352										
ZNF331	55422	broad.mit.edu	37	chr19	54080743	54080743	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtgggaaggcctttactcGagtcaattaccttactcagc	9	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:54080743G>A	ENST00000253144.9	+	7	2262	c.929G>A	c.(928-930)cGa>cAa	p.R310Q	ZNF331_ENST00000411977.2_Missense_Mutation_p.R310Q|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000513999.1_Missense_Mutation_p.R310Q|ZNF331_ENST00000449416.1_Missense_Mutation_p.R310Q|ZNF331_ENST00000511593.2_Missense_Mutation_p.R310Q|ZNF331_ENST00000512387.1_Missense_Mutation_p.R310Q|ZNF331_ENST00000511154.1_Missense_Mutation_p.R310Q	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GCCTTTACTCGAGTCAATTAC	0.473			T	?	follicular thyroid adenoma								22	42					0	0	1	0	0	A	54080743	G	A	54080743	3	1	48	1	0	0	0	0	1	0	0	0	17905	1058	37	1	939	1	ZNF331	19	54080743	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	90801	54080743	5048240	3959	8353										
NLRP12	91662	broad.mit.edu	37	chr19	54327368	54327368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcttcagttccacagcctCgagttcttccaagtaggtgg	9	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:54327368C>T	ENST00000324134.6	-	1	229	c.61G>A	c.(61-63)Gag>Aag	p.E21K	NLRP12_ENST00000354278.3_Missense_Mutation_p.E21K|NLRP12_ENST00000391773.1_Missense_Mutation_p.E21K|NLRP12_ENST00000391775.3_Missense_Mutation_p.E21K|NLRP12_ENST00000391772.1_Missense_Mutation_p.E21K|NLRP12_ENST00000351894.4_Missense_Mutation_p.E21K|NLRP12_ENST00000345770.5_Missense_Mutation_p.E21K|NLRP12_ENST00000535162.1_Missense_Mutation_p.E21K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	21	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCCACAGCCTCGAGTTCTTCC	0.612													31	40					0	0	1	0	0	T	54327368	C	T	54327368	3	4	48	1	0	0	0	0	1	0	0	0	10520	893	31	1	3260	1	NLRP12	19	54327368	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	246625	54327368	4801615	3960	8354										
CACNG7	59284	broad.mit.edu	37	chr19	54418757	54418757	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcatcttcttcatactatCgggtgagcctaaggacttgg	11	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:54418757C>T	ENST00000391767.1	+	4	634	c.422C>T	c.(421-423)tCg>tTg	p.S141L	CACNG7_ENST00000468076.1_3'UTR|CACNG7_ENST00000391766.1_Missense_Mutation_p.S141L|CACNG7_ENST00000222212.2_Missense_Mutation_p.S141L			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	141					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		TTCATACTATCGGGTGAGCCT	0.562													16	25					0	0	1	0	0	T	54418757	C	T	54418757	3	4	48	1	0	0	0	0	1	0	0	0	2580	893	31	1	432	1	CACNG7	19	54418757	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	91389	54418757	4710226	3961	8355										
LILRA5	353514	broad.mit.edu	37	chr19	54823808	54823808	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaggcttccaatctcaccGaggcagagcagaaccatgag	11	12	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:54823808G>A	ENST00000301219.3	-	2	206	c.88_splice	c.e2+1	p.L29_splice	AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000446712.3_Splice_Site_p.L29_splice|LILRA5_ENST00000432233.3_Splice_Site_p.L29_splice|LILRA5_ENST00000346508.3_Splice_Site_p.L29_splice	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	29					innate immune response	extracellular region|integral to membrane	receptor activity	p.L29L(1)		breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAATCTCACCGAGGCAGAGCA	0.602													14	49					0	0	1	0	0	A	54823808	G	A	54823808	5	1	48	1	0	0	0	0	0	0	1	0	8827	1072	37	1	922	1	LILRA5	19	54823808	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	405051	54823808	4305175	3962	8356										
LILRB1	0	broad.mit.edu	37	chr19	55144057	55144057	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacgtgacttccttcagctCgctggcgcacagccccaggc	11	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:55144057C>T	ENST00000396331.1	+	7	1161	c.804C>T	c.(802-804)ctC>ctT	p.L268L	LILRB1_ENST00000396321.2_Silent_p.L268L|LILRB1_ENST00000434867.2_Silent_p.L268L|LILRB1_ENST00000427581.2_Silent_p.L304L|LILRB1_ENST00000418536.2_Silent_p.L268L|LILRB1_ENST00000396317.1_Silent_p.L268L|LILRB1_ENST00000324602.7_Silent_p.L268L|LILRB1_ENST00000396332.4_Silent_p.L268L|LILRB1_ENST00000448689.1_Silent_p.L268L|LILRB1_ENST00000396315.1_Silent_p.L268L|LILRB1_ENST00000396327.3_Silent_p.L268L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	268	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TCCTTCAGCTCGCTGGCGCAC	0.612										HNSCC(37;0.09)			36	77					0	0	1	0	0	T	55144057	C	T	55144057	2	4	48	1	0	0	0	0	0	0	0	1	8829	871	31	1		1	LILRB1	19	55144057	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	320249	55144057	3984926	3963	8357										
NLRP7	199713	broad.mit.edu	37	chr19	55449593	55449593	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgccgagcccagttcggaaTggttaggtaagtgcacctgc	13	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:55449593T>G	ENST00000446217.1	-	7	2434	c.2032A>C	c.(2032-2034)Att>Ctt	p.I678L	NLRP7_ENST00000448121.2_Intron|NLRP7_ENST00000328092.5_Intron|NLRP7_ENST00000340844.2_Missense_Mutation_p.I650L|NLRP7_ENST00000592784.1_Missense_Mutation_p.I650L|NLRP7_ENST00000590030.1_Missense_Mutation_p.I650L|NLRP7_ENST00000588756.1_Missense_Mutation_p.I650L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	650							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CAGTTCGGAATGGTTAGGTAA	0.488													30	60					0	0	1	0	0	G	55449593	T	G	55449593	3	3	48	1	0	0	0	0	1	0	0	0	10528	1464	51	4	1193	4	NLRP7	19	55449593	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	305536	55449593	3679390	3964	8358										
NLRP7	199713	broad.mit.edu	37	chr19	55450260	55450260	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaaaacagttcttacctttCaaattcaatgtccagttcaa	5	9	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:55450260C>A	ENST00000446217.1	-	6	2413	c.2011G>T	c.(2011-2013)Gaa>Taa	p.E671*	NLRP7_ENST00000448121.2_Nonsense_Mutation_p.E643*|NLRP7_ENST00000328092.5_Nonsense_Mutation_p.E643*|NLRP7_ENST00000340844.2_Nonsense_Mutation_p.E643*|NLRP7_ENST00000592784.1_Nonsense_Mutation_p.E643*|NLRP7_ENST00000590030.1_Nonsense_Mutation_p.E643*|NLRP7_ENST00000588756.1_Nonsense_Mutation_p.E643*			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	643							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCTTACCTTTCAAATTCAATG	0.483													30	77					5.60225e-13	7.13348e-13	1	1	0	A	55450260	C	A	55450260	4	1	48	1	0	0	0	0	0	1	0	0	10528	835	29	2	1218	2	NLRP7	19	55450260	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	667	55450260	3678723	3965	8359										
NLRP7	199713	broad.mit.edu	37	chr19	55451265	55451265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcgccaggagctggaggtCcctcagtgccctgggccgcg	16	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:55451265C>T	ENST00000446217.1	-	6	1408	c.1006G>A	c.(1006-1008)Gac>Aac	p.D336N	NLRP7_ENST00000448121.2_Missense_Mutation_p.D308N|NLRP7_ENST00000328092.5_Missense_Mutation_p.D308N|NLRP7_ENST00000340844.2_Missense_Mutation_p.D308N|NLRP7_ENST00000592784.1_Missense_Mutation_p.D308N|NLRP7_ENST00000590030.1_Missense_Mutation_p.D308N|NLRP7_ENST00000588756.1_Missense_Mutation_p.D308N			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	308	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGCTGGAGGTCCCTCAGTGCC	0.617													17	27					0	0	1	0	0	T	55451265	C	T	55451265	3	4	48	1	0	0	0	0	1	0	0	0	10528	855	30	3	2223	3	NLRP7	19	55451265	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1005	55451265	3677718	3966	8360										
TNNT1	7138	broad.mit.edu	37	chr19	55649407	55649407	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatcatcctctgcccgcttCttggcctcttcctcttcctt	5	18	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:55649407C>A	ENST00000588981.1	-	10	627	c.423G>T	c.(421-423)aaG>aaT	p.K141N	TNNT1_ENST00000585321.2_Missense_Mutation_p.K71N|TNNT1_ENST00000291901.8_Missense_Mutation_p.K141N|TNNT1_ENST00000588426.1_Missense_Mutation_p.K38N|TNNT1_ENST00000356783.5_Missense_Mutation_p.K130N|TNNT1_ENST00000536926.1_Missense_Mutation_p.K130N|TNNT1_ENST00000587465.2_Missense_Mutation_p.K71N|TNNT1_ENST00000587758.1_Missense_Mutation_p.K130N|TNNT1_ENST00000592920.1_5'UTR	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	141					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CTGCCCGCTTCTTGGCCTCTT	0.572													13	98					7.93312e-07	8.98086e-07	1	1	0	A	55649407	C	A	55649407	3	1	48	1	0	0	0	0	1	0	0	0	16389	912	32	2	433	2	TNNT1	19	55649407	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	198142	55649407	3479576	3967	8361										
TNNI3	7137	broad.mit.edu	37	chr19	55665401	55665401	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttagcccacactcaccttCtcggtgtcctccttcttcac	4	19	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:55665401C>A	ENST00000344887.5	-	7	688	c.546G>T	c.(544-546)gaG>gaT	p.E182D	TNNI3_ENST00000588882.1_Missense_Mutation_p.E157D	NM_000363.4	NP_000354.4	P19429	TNNI3_HUMAN	troponin I type 3 (cardiac)	182					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CACTCACCTTCTCGGTGTCCT	0.622													37	66					2.75727e-19	3.7504e-19	1	1	0	A	55665401	C	A	55665401	3	1	48	1	0	0	0	0	1	0	0	0	16387	912	32	2	94	2	TNNI3	19	55665401	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15994	55665401	3463582	3968	8362										
NLRP9	338321	broad.mit.edu	37	chr19	56243645	56243645	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggttatttcctgctttaggtCttttgacagtggaaaaccaa	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56243645C>A	ENST00000332836.2	-	2	1579	c.1552G>T	c.(1552-1554)Gac>Tac	p.D518Y		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	518						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TGCTTTAGGTCTTTTGACAGT	0.418													41	63					2.19489e-29	3.12373e-29	1	1	0	A	56243645	C	A	56243645	3	1	48	1	0	0	0	0	1	0	0	0	10530	913	32	2	1455	2	NLRP9	19	56243645	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	578244	56243645	2885338	3969	8363										
NLRP11	204801	broad.mit.edu	37	chr19	56329275	56329275	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgaccccactcacggtttCgtctgccaatgatcttccta	7	15	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56329275C>T	ENST00000443188.1	-	4	976	c.266G>A	c.(265-267)cGa>cAa	p.R89Q	NLRP11_ENST00000589093.1_Missense_Mutation_p.R89Q|NLRP11_ENST00000592953.1_Intron|NLRP11_ENST00000589824.2_Missense_Mutation_p.R89Q|NLRP11_ENST00000360133.3_Missense_Mutation_p.R89Q	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	89	DAPIN.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTCACGGTTTCGTCTGCCAAT	0.418													27	39					0	0	1	0	0	T	56329275	C	T	56329275	3	4	48	1	0	0	0	0	1	0	0	0	10519	884	31	1	2871	1	NLRP11	19	56329275	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	85630	56329275	2799708	3970	8364										
NLRP8	126205	broad.mit.edu	37	chr19	56485190	56485190	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcctctgcagaggctggtgTaagtcccagaatgttttctt	11	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56485190T>C	ENST00000291971.3	+	7	2776		c.e7+2		NLRP8_ENST00000590542.1_Splice_Site	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8							cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGGCTGGTGTAAGTCCCAGA	0.458													5	86					0	0	1	0	0	C	56485190	T	C	56485190	5	2	48	1	0	0	0	0	0	0	1	0	10529	1652	57	4	2733	4	NLRP8	19	56485190	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	155915	56485190	2643793	3971	8365										
NLRP5	126206	broad.mit.edu	37	chr19	56538862	56538862	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaagctcaagtcagaggtCgtgtctccccgttacctgtt	11	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56538862C>T	ENST00000390649.3	+	7	1263	c.1263C>T	c.(1261-1263)gtC>gtT	p.V421V		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	421	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AGTCAGAGGTCGTGTCTCCCC	0.547													17	22					0	0	1	0	0	T	56538862	C	T	56538862	2	4	48	1	0	0	0	0	0	0	0	1	10526	871	31	1		1	NLRP5	19	56538862	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53672	56538862	2590121	3972	8366										
ZSCAN5A	79149	broad.mit.edu	37	chr19	56736267	56736267	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgactccttcgggcagctgAacatcctgaagttcacgtga	10	13	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56736267A>C	ENST00000587340.1	-	4	844	c.149T>G	c.(148-150)tTc>tGc	p.F50C	ZSCAN5A_ENST00000592355.1_Missense_Mutation_p.F50C|ZSCAN5A_ENST00000587492.1_Intron|ZSCAN5A_ENST00000254165.3_Intron|ZSCAN5A_ENST00000391713.1_Missense_Mutation_p.F50C			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	50	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CGGGCAGCTGAACATCCTGAA	0.557													27	50					0	0	1	0	0	C	56736267	A	C	56736267	3	2	48	1	0	0	0	0	1	0	0	0	18277	246	9	4	1357	4	ZSCAN5A	19	56736267	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	197405	56736267	2392716	3973	8367										
ZNF583	147949	broad.mit.edu	37	chr19	56935607	56935607	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaatgtaaagattgcaggaAatctttcaggcagcgtgcac	11	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56935607A>C	ENST00000333201.9	+	5	1790	c.1580A>C	c.(1579-1581)aAa>aCa	p.K527T	ZNF583_ENST00000291598.7_Missense_Mutation_p.K527T|ZNF583_ENST00000585612.1_Intron	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		GATTGCAGGAAATCTTTCAGG	0.408													25	56					0	0	1	0	0	C	56935607	A	C	56935607	3	2	48	1	0	0	0	0	1	0	0	0	18071	14	1	4	1594	4	ZNF583	19	56935607	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	199340	56935607	2193376	3974	8368										
ZNF583	147949	broad.mit.edu	37	chr19	56935644	56935644	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacatcttgctcatcatgaGagaattcatactatggagtc	8	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56935644G>A	ENST00000333201.9	+	5	1827	c.1617G>A	c.(1615-1617)gaG>gaA	p.E539E	ZNF583_ENST00000291598.7_Silent_p.E539E|ZNF583_ENST00000585612.1_Intron	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	539					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		CTCATCATGAGAGAATTCATa	0.418													13	42					0	0	1	0	0	A	56935644	G	A	56935644	2	1	48	1	0	0	0	0	0	0	0	1	18071	933	33	3		3	ZNF583	19	56935644	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	37	56935644	2193339	3975	8369										
ZNF667	63934	broad.mit.edu	37	chr19	56953524	56953524	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccacatttattatatttatgTgttttctttccattgtgaat	4	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:56953524T>C	ENST00000504904.3	-	7	1559	c.840A>G	c.(838-840)acA>acG	p.T280T	ZNF667_ENST00000342634.3_Silent_p.T408T|ZNF667_ENST00000292069.6_Silent_p.T280T|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TATATTTATGTGTTTTCTTTC	0.363													14	49					0	0	1	0	0	C	56953524	T	C	56953524	2	2	48	1	0	0	0	0	0	0	0	1	18130	1683	59	4		4	ZNF667	19	56953524	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	17880	56953524	2175459	3976	8370										
ZNF471	57573	broad.mit.edu	37	chr19	57036962	57036962	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctactcatcagagaattcAtactggagagaagccttatg	10	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57036962A>G	ENST00000308031.5	+	5	1659	c.1526A>G	c.(1525-1527)cAt>cGt	p.H509R	ZNF471_ENST00000593197.1_Intron|ZNF471_ENST00000591537.1_3'UTR	NM_020813.2	NP_065864.2	Q9BX82	ZN471_HUMAN	zinc finger protein 471	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(8)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		CAGAGAATTCATACTGGAGAG	0.378													25	42					0	0	1	0	0	G	57036962	A	G	57036962	3	3	48	1	0	0	0	0	1	0	0	0	17986	217	8	4	1540	4	ZNF471	19	57036962	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	83438	57036962	2092021	3977	8371										
ZNF470	388566	broad.mit.edu	37	chr19	57088168	57088168	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccggcaatcataatggaaaGacttaaaagctatgaccttg	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57088168G>T	ENST00000330619.8	+	6	1057	c.371G>T	c.(370-372)aGa>aTa	p.R124I	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.R124I	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATAATGGAAAGACTTAAAAGC	0.363													10	34					7.48243e-07	8.49459e-07	1	1	0	T	57088168	G	T	57088168	3	4	48	1	0	0	0	0	1	0	0	0	17985	942	33	2	385	2	ZNF470	19	57088168	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	51206	57088168	2040815	3978	8372										
ZIM2	23619	broad.mit.edu	37	chr19	57290833	57290833	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataatgtcaggtttagagaaCtggtgccctgttggagagga	14	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57290833C>A	ENST00000391708.3	-	11	1196	c.654G>T	c.(652-654)caG>caT	p.Q218H	ZIM2_ENST00000599935.1_Missense_Mutation_p.Q218H|ZIM2_ENST00000601070.1_Missense_Mutation_p.Q218H|ZIM2_ENST00000221722.5_Missense_Mutation_p.Q218H|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000593711.1_Missense_Mutation_p.Q218H	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		GTTTAGAGAACTGGTGCCCTG	0.458													4	73					0.00024832	0.000265255	1	1	0	A	57290833	C	A	57290833	3	1	48	1	0	0	0	0	1	0	0	0	17741	564	20	5	937	5	ZIM2	19	57290833	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	202665	57290833	1838150	3979	8373										
PEG3	5178	broad.mit.edu	37	chr19	57326134	57326134	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgtccacacaaaaggcatcGaatggccgacccagcaagag	10	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57326134G>A	ENST00000326441.9	-	10	4039	c.3676C>T	c.(3676-3678)Cga>Tga	p.R1226*	PEG3_ENST00000598410.1_Nonsense_Mutation_p.R1102*|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000423103.2_Nonsense_Mutation_p.R1226*|PEG3_ENST00000593695.1_Nonsense_Mutation_p.R1100*|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1226					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R1226>?(2)		NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAAAGGCATCGAATGGCCGAC	0.502													30	48					0	0	1	0	0	A	57326134	G	A	57326134	4	1	48	1	0	0	0	0	0	1	0	0	11766	1066	37	1	1094	1	PEG3	19	57326134	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	35301	57326134	1802849	3980	8374										
PEG3	5178	broad.mit.edu	37	chr19	57327758	57327758	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggccatctgtaaagtcacaGagcttctccttattgtaagt	8	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57327758G>A	ENST00000326441.9	-	10	2415	c.2052C>T	c.(2050-2052)ctC>ctT	p.L684L	PEG3_ENST00000598410.1_Silent_p.L560L|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000423103.2_Silent_p.L684L|PEG3_ENST00000593695.1_Silent_p.L558L|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	684					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TAAAGTCACAGAGCTTCTCCT	0.448													16	62					0	0	1	0	0	A	57327758	G	A	57327758	2	1	48	1	0	0	0	0	0	0	0	1	11766	929	33	3		3	PEG3	19	57327758	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1624	57327758	1801225	3981	8375										
PEG3	5178	broad.mit.edu	37	chr19	57335881	57335881	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catagattaggttccgaaacCtctgatgaaaaaactcagag	8	8	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57335881C>A	ENST00000326441.9	-	4	506	c.143G>T	c.(142-144)aGg>aTg	p.R48M	PEG3_ENST00000598410.1_Intron|ZIM2_ENST00000599935.1_De_novo_Start_InFrame|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.R48M|PEG3_ENST00000593695.1_Intron|ZIM2_ENST00000391708.3_De_novo_Start_InFrame|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000594706.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	48	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTTCCGAAACCTCTGATGAAA	0.507													24	32					6.21321e-17	8.30052e-17	1	1	0	A	57335881	C	A	57335881	3	1	48	1	0	0	0	0	1	0	0	0	11766	695	24	5		5	PEG3	19	57335881	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8123	57335881	1793102	3982	8376										
USP29	0	broad.mit.edu	37	chr19	57640183	57640183	+	Missense_Mutation	SNP	T	T	G													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactttcaaatctggaaaatTtataagaatttttcagctga							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57640183T>G	ENST00000254181.4	+	4	594	c.140T>G	c.(139-141)tTt>tGt	p.F47C	USP29_ENST00000598197.1_Missense_Mutation_p.F47C	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	47					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTGGAAAATTTATAAGAATT	0.363													9	25					0	0	1	0	0	G	57640183	T	G	57640183	3	3	48	1	0	0	0	0	1	0	0	0	17118	1841	64	4	142	4	USP29	19	57640183	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	304302	57640183	1488800	3983	8377	26	2								
USP29	0	broad.mit.edu	37	chr19	57640189	57640189	+	Missense_Mutation	SNP	G	G	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaatctggaaaatttataaGaatttttcagctgagcaaca							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57640189G>T	ENST00000254181.4	+	4	600	c.146G>T	c.(145-147)aGa>aTa	p.R49I	USP29_ENST00000598197.1_Missense_Mutation_p.R49I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	49					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAATTTATAAGAATTTTTCAG	0.353													13	17					0.000219431	0.000235335	1	1	0	T	57640189	G	T	57640189	3	4	48	1	0	0	0	0	1	0	0	0	17118	942	33	2	148	2	USP29	19	57640189	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6	57640189	1488794	3984	8378	26	2								
USP29	0	broad.mit.edu	37	chr19	57642424	57642424	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggttctgacaacccaggaaAcaaaaacattttagatgcag	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57642424A>G	ENST00000254181.4	+	4	2835	c.2381A>G	c.(2380-2382)aAc>aGc	p.N794S	USP29_ENST00000598197.1_Missense_Mutation_p.N794S	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	794					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AACCCAGGAAACAAAAACATT	0.458													5	37					0	0	1	0	0	G	57642424	A	G	57642424	3	3	48	1	0	0	0	0	1	0	0	0	17118	43	2	4	2383	4	USP29	19	57642424	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2235	57642424	1486559	3985	8379										
ZIM3	0	broad.mit.edu	37	chr19	57646993	57646993	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattttctgatgttgaaagaGatttgacttctgcttgtagg	10	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57646993G>T	ENST00000269834.1	-	5	1097	c.712C>A	c.(712-714)Ctc>Atc	p.L238I		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTTGAAAGAGATTTGACTTC	0.403													28	51					4.87955e-14	6.31333e-14	1	1	0	T	57646993	G	T	57646993	3	4	48	1	0	0	0	0	1	0	0	0	17742	942	33	2	710	2	ZIM3	19	57646993	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4569	57646993	1481990	3986	8380										
ZIM3	0	broad.mit.edu	37	chr19	57647266	57647266	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctgtatccattatcatCgtgagaattattttgtacat	5	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57647266C>T	ENST00000269834.1	-	5	824	c.439G>A	c.(439-441)Gat>Aat	p.D147N		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCATTATCATCGTGAGAATTA	0.353													41	87					0	0	1	0	0	T	57647266	C	T	57647266	3	4	48	1	0	0	0	0	1	0	0	0	17742	884	31	1	983	1	ZIM3	19	57647266	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	273	57647266	1481717	3987	8381										
ZNF460	10794	broad.mit.edu	37	chr19	57802428	57802428	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggaaaattcctataaattCgaggaaatgtttaatgagaa	10	3	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57802428C>T	ENST00000360338.3	+	3	841	c.519C>T	c.(517-519)ttC>ttT	p.F173F	ZNF460_ENST00000537645.1_Silent_p.F132F	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCTATAAATTCGAGGAAATGT	0.428													32	64					0	0	1	0	0	T	57802428	C	T	57802428	2	4	48	1	0	0	0	0	0	0	0	1	17980	883	31	1		1	ZNF460	19	57802428	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	155162	57802428	1326555	3988	8382										
ZNF543	125919	broad.mit.edu	37	chr19	57839976	57839976	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttgcgagagtgcagacctCattcaacactacattatcca	6	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57839976C>A	ENST00000321545.4	+	4	1491	c.1146C>A	c.(1144-1146)ctC>ctA	p.L382L		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGCAGACCTCATTCAACACT	0.507													26	56					3.6726e-16	4.87283e-16	1	1	0	A	57839976	C	A	57839976	2	1	48	1	0	0	0	0	0	0	0	1	18032	813	29	2		2	ZNF543	19	57839976	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	37548	57839976	1289007	3989	8383										
VN1R1	57191	broad.mit.edu	37	chr19	57967372	57967372	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaaccttggggatctaatCttgatctccatccacctgca	6	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:57967372C>A	ENST00000321039.3	-	1	482	c.483G>T	c.(481-483)aaG>aaT	p.K161N	AC004076.9_ENST00000596831.1_Intron|AC004076.9_ENST00000415705.3_Intron	NM_020633.3	NP_065684.1	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	161					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		GGGATCTAATCTTGATCTCCA	0.483													7	72					0.248553	0.24944	1	1	0	A	57967372	C	A	57967372	3	1	48	1	0	0	0	0	1	0	0	0	17237	912	32	2	582	2	VN1R1	19	57967372	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	127396	57967372	1161611	3990	8384										
ZNF549	256051	broad.mit.edu	37	chr19	58049412	58049412	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attccgccacaaacaaacatTtgttggccatcagcagagaa	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58049412T>G	ENST00000376233.3	+	4	1221	c.1040T>G	c.(1039-1041)tTt>tGt	p.F347C	ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000602149.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.F334C	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAACAAACATTTGTTGGCCAT	0.438													29	50					0	0	1	0	0	G	58049412	T	G	58049412	3	3	48	1	0	0	0	0	1	0	0	0	18037	1841	64	4	1011	4	ZNF549	19	58049412	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	82040	58049412	1079571	3991	8385										
ZNF549	256051	broad.mit.edu	37	chr19	58049766	58049766	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgactacatgcgacaccagaGaattcacactggagaaaggg	11	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58049766G>T	ENST00000376233.3	+	4	1575	c.1394G>T	c.(1393-1395)aGa>aTa	p.R465I	ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000602149.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.R452I	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGACACCAGAGAATTCACACT	0.428													21	39					6.33239e-15	8.29613e-15	1	1	0	T	58049766	G	T	58049766	3	4	48	1	0	0	0	0	1	0	0	0	18037	942	33	2	1365	2	ZNF549	19	58049766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	354	58049766	1079217	3992	8386										
ZNF416	55659	broad.mit.edu	37	chr19	58084262	58084262	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcaataaggttggaacttTggctaaaagatttcccacat	8	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58084262T>G	ENST00000196489.3	-	4	1232	c.1010A>C	c.(1009-1011)cAa>cCa	p.Q337P		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		GTTGGAACTTTGGCTAAAAGA	0.428													28	60					0	0	1	0	0	G	58084262	T	G	58084262	3	3	48	1	0	0	0	0	1	0	0	0	17949	1812	63	4	778	4	ZNF416	19	58084262	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	34496	58084262	1044721	3993	8387										
ZIK1	284307	broad.mit.edu	37	chr19	58101659	58101659	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgtgaagtgctgcctattCtgtatgtcattgaagccctt	9	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58101659C>A	ENST00000597850.1	+	4	695	c.480C>A	c.(478-480)ttC>ttA	p.F160L	ZIK1_ENST00000599456.1_Missense_Mutation_p.F105L|ZIK1_ENST00000307468.4_3'UTR|ZIK1_ENST00000536878.2_Missense_Mutation_p.F147L	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCTGCCTATTCTGTATGTCAT	0.493													22	41					6.44725e-10	7.85205e-10	1	1	0	A	58101659	C	A	58101659	3	1	48	1	0	0	0	0	1	0	0	0	17740	912	32	2	494	2	ZIK1	19	58101659	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17397	58101659	1027324	3994	8388										
ZNF530	348327	broad.mit.edu	37	chr19	58118092	58118092	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttattcaccaccaaagatTtcacactggagaaagacctt	5	12	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58118092T>G	ENST00000332854.6	+	3	1419	c.1199T>G	c.(1198-1200)tTt>tGt	p.F400C	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CACCAAAGATTTCACACTGGA	0.423													56	69					0	0	1	0	0	G	58118092	T	G	58118092	3	3	48	1	0	0	0	0	1	0	0	0	18027	1841	64	4	1209	4	ZNF530	19	58118092	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	16433	58118092	1010891	3995	8389										
ZNF551	90233	broad.mit.edu	37	chr19	58199270	58199270	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggcaaatcttttagacagCgctctggcctcattcagcac	9	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58199270C>T	ENST00000282296.5	+	3	1812	c.1627C>T	c.(1627-1629)Cgc>Tgc	p.R543C	AC003006.7_ENST00000599221.1_Intron|ZNF551_ENST00000356715.4_Missense_Mutation_p.R527C|AC003006.7_ENST00000596085.1_Intron	NM_001270938.1	NP_001257867.1	Q7Z340	ZN551_HUMAN	zinc finger protein 551	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTTTAGACAGCGCTCTGGCCT	0.443													23	60					0	0	1	0	0	T	58199270	C	T	58199270	3	4	48	1	0	0	0	0	1	0	0	0	18039	768	27	1	1589	1	ZNF551	19	58199270	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	81178	58199270	929713	3996	8390										
ZNF418	147686	broad.mit.edu	37	chr19	58441904	58441904	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaaaagttcacagccacatCttcaaatgccacagtgccct	7	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58441904C>A	ENST00000396147.1	-	3	316	c.25G>T	c.(25-27)Gat>Tat	p.D9Y	ZNF418_ENST00000425570.3_Missense_Mutation_p.D30Y|ZNF418_ENST00000595830.1_Missense_Mutation_p.D9Y|ZNF418_ENST00000599852.1_Intron|ZNF418_ENST00000600989.1_Missense_Mutation_p.D9Y	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	9	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		ACAGCCACATCTTCAAATGCC	0.512													34	82					2.20474e-14	2.87106e-14	1	1	0	A	58441904	C	A	58441904	3	1	48	1	0	0	0	0	1	0	0	0	17951	913	32	2	2013	2	ZNF418	19	58441904	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	242634	58441904	687079	3997	8391										
ZNF256	10172	broad.mit.edu	37	chr19	58452990	58452990	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgtgaagtctccggtgttTaatgaggtgacagctctggc	13	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58452990T>C	ENST00000282308.3	-	3	1382	c.1186A>G	c.(1186-1188)Aaa>Gaa	p.K396E	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	396					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		CTCCGGTGTTTAATGAGGTGA	0.428													30	41					0	0	1	0	0	C	58452990	T	C	58452990	3	2	48	1	0	0	0	0	1	0	0	0	17856	1763	61	4	701	4	ZNF256	19	58452990	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	11086	58452990	675993	3998	8392										
C19orf18	147685	broad.mit.edu	37	chr19	58472793	58472793	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttccagctcattttcgttCtctggaagtaggtgcgtgga	11	8	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58472793C>T	ENST00000314391.3	-	5	599	c.498G>A	c.(496-498)gaG>gaA	p.E166E		NM_152474.4	NP_689687.1	Q8NEA5	CS018_HUMAN	chromosome 19 open reading frame 18	166						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		CATTTTCGTTCTCTGGAAGTA	0.488													19	41					0	0	1	0	0	T	58472793	C	T	58472793	2	4	48	1	0	0	0	0	0	0	0	1	1922	912	32	3		3	C19orf18	19	58472793	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19803	58472793	656190	3999	8393										
ZNF135	7694	broad.mit.edu	37	chr19	58578538	58578538	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctttagtcacagctcagcacTtatcgaacaccaccggacgc	7	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58578538T>G	ENST00000506786.1	+	5	1114	c.560T>G	c.(559-561)cTt>cGt	p.L187R	ZNF135_ENST00000313434.5_Missense_Mutation_p.L229R|ZNF135_ENST00000359978.6_Missense_Mutation_p.L241R|ZNF135_ENST00000401053.4_Missense_Mutation_p.L253R|ZNF135_ENST00000511556.1_Missense_Mutation_p.L241R|ZNF135_ENST00000439855.2_Missense_Mutation_p.L229R			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	241					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AGCTCAGCACTTATCGAACAC	0.473													69	130					0	0	1	0	0	G	58578538	T	G	58578538	3	3	48	1	0	0	0	0	1	0	0	0	17782	1609	56	4	889	4	ZNF135	19	58578538	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	105745	58578538	550445	4000	8394										
ZNF544	27300	broad.mit.edu	37	chr19	58773431	58773431	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacacataaaagaacgcacActggagaaaaacccttcaaa	5	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:58773431A>G	ENST00000269829.4	+	7	1933	c.1459A>G	c.(1459-1461)Act>Gct	p.T487A	CTD-3138B18.4_ENST00000600029.1_Intron|CTD-3138B18.5_ENST00000597230.1_RNA|ZNF544_ENST00000600044.1_Missense_Mutation_p.T459A|ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000599953.1_Missense_Mutation_p.T345A|ZNF544_ENST00000596825.1_3'UTR|ZNF544_ENST00000596652.1_Missense_Mutation_p.T487A|ZNF544_ENST00000600220.1_Missense_Mutation_p.T459A|ZNF544_ENST00000415203.2_Missense_Mutation_p.T459A|ZNF544_ENST00000599227.1_3'UTR|ZNF544_ENST00000595981.1_Intron	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AAGAACGCACACTGGAGAAAA	0.433													27	73					0	0	1	0	0	G	58773431	A	G	58773431	3	3	48	1	0	0	0	0	1	0	0	0	18033	159	6	4	1473	4	ZNF544	19	58773431	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	194893	58773431	355552	4001	8395										
UBE2M	9040	broad.mit.edu	37	chr19	59067707	59067707	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagatactgcaggccataAattatggagtttatcgtaag	10	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:59067707A>C	ENST00000253023.3	-	5	965	c.387T>G	c.(385-387)atT>atG	p.I129M		NM_003969.3	NP_003960.1	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	129					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	5		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		GCAGGCCATAAATTATGGAGT	0.547													28	63					0	0	1	0	0	C	59067707	A	C	59067707	3	2	48	1	0	0	0	0	1	0	0	0	16925	10	1	4	172	4	UBE2M	19	59067707	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	294276	59067707	61276	4002	8396										
UBE2M	9040	broad.mit.edu	37	chr19	59068073	59068073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgaggatgttgaggcagaCgttgccctcgaggtcaatgt	14	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr19:59068073C>T	ENST00000253023.3	-	4	906	c.328G>A	c.(328-330)Gtc>Atc	p.V110I		NM_003969.3	NP_003960.1	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	110					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity	p.V110I(1)		large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	5		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TTGAGGCAGACGTTGCCCTCG	0.587													10	28					0	0	1	0	0	T	59068073	C	T	59068073	3	4	48	1	0	0	0	0	1	0	0	0	16925	536	19	1	235	1	UBE2M	19	59068073	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	366	59068073	60910	4003	8397										
DEFB126	81623	broad.mit.edu	37	chr20	126299	126299	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactactgcttcgatgtcttCgatggctcctacccccgttt	8	14	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:126299C>T	ENST00000382398.3	+	2	562	c.302C>T	c.(301-303)tCg>tTg	p.S101L	DEFB126_ENST00000542572.1_3'UTR	NM_030931.2	NP_112193.1	Q9BYW3	DB126_HUMAN	defensin, beta 126	101					defense response to bacterium	extracellular region				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TCGATGTCTTCGATGGCTCCT	0.453													48	73					0	0	1	0	0	T	126299	C	T	126299	3	4	48	1	0	0	0	0	1	0	0	0	4439	893	31	1	308	1	DEFB126	20	126299	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		126299	62899221	4004	8398										
ANGPT4	51378	broad.mit.edu	37	chr20	858965	858965	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctccccagctgggtctccGaagccctatagggaggggag	15	12	1	0	rs112090528	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:858965G>A	ENST00000381922.3	-	7	1161	c.1059C>T	c.(1057-1059)ttC>ttT	p.F353F	ANGPT4_ENST00000546022.1_Silent_p.F353F	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4	353	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						CTGGGTCTCCGAAGCCCTATA	0.632													13	19					0	0	1	0	0	A	858965	G	A	858965	2	1	48	1	0	0	0	0	0	0	0	1	608	1049	37	1		1	ANGPT4	20	858965	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	732666	858965	62166555	4005	8399										
SNPH	9751	broad.mit.edu	37	chr20	1285531	1285531	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcggctcgcagggacacagaGattgatgacctgaagacgca	13	10	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:1285531G>A	ENST00000381867.1	+	7	1092	c.450G>A	c.(448-450)gaG>gaA	p.E150E	SNPH_ENST00000381873.3_Silent_p.E106E			O15079	SNPH_HUMAN	syntaphilin	106					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			endometrium(2)|large_intestine(4)|lung(10)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GGGACACAGAGATTGATGACC	0.627													29	72					0	0	1	0	0	A	1285531	G	A	1285531	2	1	48	1	0	0	0	0	0	0	0	1	14903	933	33	3		3	SNPH	20	1285531	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	426566	1285531	61739989	4006	8400										
SIRPB2	284759	broad.mit.edu	37	chr20	1460374	1460374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcactgaggtgccttcatccGatttcatttctgagtgttca	9	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:1460374G>A	ENST00000359801.3	-	2	458	c.422C>T	c.(421-423)tCg>tTg	p.S141L	SIRPB2_ENST00000444444.1_Intron|SIRPB2_ENST00000381630.1_Intron|SIRPB2_ENST00000537284.1_Missense_Mutation_p.S3L	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	141	Ig-like V-type 1.					integral to membrane		p.S240L(1)|p.S141L(1)		endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCCTTCATCCGATTTCATTTC	0.478													55	119					0	0	1	0	0	A	1460374	G	A	1460374	3	1	48	1	0	0	0	0	1	0	0	0	14388	1059	37	1	622	1	SIRPB2	20	1460374	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	174843	1460374	61565146	4007	8401										
SIRPG	55423	broad.mit.edu	37	chr20	1617063	1617063	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggtgatgtctctgggagaGaagccatgggactcacaggt	16	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:1617063G>T	ENST00000381580.1	-	3	599	c.420C>A	c.(418-420)ttC>ttA	p.F140L	SIRPG_ENST00000303415.3_Missense_Mutation_p.F173L|SIRPG_ENST00000216927.4_Missense_Mutation_p.F173L|SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000381583.2_Missense_Mutation_p.F173L|RP11-77C3.3_ENST00000456177.1_RNA			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	173					blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding	p.F173L(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						CTCTGGGAGAGAAGCCATGGG	0.557													37	50					6.53348e-20	8.92126e-20	1	1	0	T	1617063	G	T	1617063	3	4	48	1	0	0	0	0	1	0	0	0	14390	933	33	2	656	2	SIRPG	20	1617063	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	156689	1617063	61408457	4008	8402										
TMC2	117532	broad.mit.edu	37	chr20	2597824	2597824	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgagcagcaacgtaccccatGaacgcgtgttcaaagcctcc	9	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:2597824G>T	ENST00000358864.1	+	16	2062	c.2047G>T	c.(2047-2049)Gaa>Taa	p.E683*	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	683						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CGTACCCCATGAACGCGTGTT	0.582													9	92					0.000442599	0.00046913	1	1	0	T	2597824	G	T	2597824	4	4	48	1	0	0	0	0	0	1	0	0	16044	1291	45	2	2109	2	TMC2	20	2597824	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	980761	2597824	60427696	4009	8403										
NOP56	10528	broad.mit.edu	37	chr20	2638687	2638687	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaacccaagaaaaagaaatCtttttccaaggaggagttga	8	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:2638687C>A	ENST00000329276.5	+	12	2048	c.1532C>A	c.(1531-1533)tCt>tAt	p.S511Y	NOP56_ENST00000492135.1_3'UTR	NM_006392.3	NP_006383.2	O00567	NOP56_HUMAN	NOP56 ribonucleoprotein	511	Lys-rich.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25						AAAAAGAAATCTTTTTCCAAG	0.448													28	51					8.58068e-18	1.15595e-17	1	1	0	A	2638687	C	A	2638687	3	1	48	1	0	0	0	0	1	0	0	0	10585	913	32	2	1578	2	NOP56	20	2638687	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	40863	2638687	60386833	4010	8404										
IDH3B	3420	broad.mit.edu	37	chr20	2641599	2641599	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctcccccttatactccatCggggtatgaatctttcctgt	7	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:2641599C>T	ENST00000380843.4	-	5	384	c.354G>A	c.(352-354)ccG>ccA	p.P118P	IDH3B_ENST00000380851.5_Silent_p.P118P|IDH3B_ENST00000488299.1_5'UTR	NM_006899.3	NP_008830.2	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3 (NAD+) beta	118					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding	p.P118P(1)		breast(1)|endometrium(3)|kidney(2)|lung(7)|prostate(1)	14					NADH(DB00157)	TATACTCCATCGGGGTATGAA	0.547													24	35					0	0	1	0	0	T	2641599	C	T	2641599	2	4	48	1	0	0	0	0	0	0	0	1	7540	871	31	1		1	IDH3B	20	2641599	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2912	2641599	60383921	4011	8405										
VPS16	64601	broad.mit.edu	37	chr20	2841107	2841107	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcctcaggaagtgctccagAaccgggttctggatgcccgg	13	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:2841107A>T	ENST00000380445.3	+	5	454	c.382A>T	c.(382-384)Aac>Tac	p.N128Y	VPS16_ENST00000380469.3_Missense_Mutation_p.N128Y	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	128					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						AGTGCTCCAGAACCGGGTTCT	0.602													30	49					0	0	1	0	0	T	2841107	A	T	2841107	3	4	48	1	0	0	0	0	1	0	0	0	17252	246	9	4	400	4	VPS16	20	2841107	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	199508	2841107	60184413	4012	8406										
VPS16	64601	broad.mit.edu	37	chr20	2843543	2843543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcgtgtgctcaatgctgttCgggactatcacatcgggatc	12	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:2843543C>T	ENST00000380445.3	+	13	1366	c.1294C>T	c.(1294-1296)Cgg>Tgg	p.R432W	VPS16_ENST00000380469.3_Intron|VPS16_ENST00000380443.3_Missense_Mutation_p.R118W|VPS16_ENST00000481812.2_3'UTR	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	432					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						CAATGCTGTTCGGGACTATCA	0.587													72	105					0	0	1	0	0	T	2843543	C	T	2843543	3	4	48	1	0	0	0	0	1	0	0	0	17252	875	31	1	1344	1	VPS16	20	2843543	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2436	2843543	60181977	4013	8407										
FASTKD5	60493	broad.mit.edu	37	chr20	3127883	3127883	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagccttaatttggctacatTttcagccggcgtggcttctc	9	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:3127883T>G	ENST00000380266.3	-	2	2155	c.1834A>C	c.(1834-1836)Aat>Cat	p.N612H	UBOX5_ENST00000348031.2_Intron|UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	612					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						TTGGCTACATTTTCAGCCGGC	0.428													40	65					0	0	1	0	0	G	3127883	T	G	3127883	3	3	48	1	0	0	0	0	1	0	0	0	5720	1841	64	4	464	4	FASTKD5	20	3127883	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	284340	3127883	59897637	4014	8408										
FASTKD5	60493	broad.mit.edu	37	chr20	3129698	3129698	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtatcttacaagttttaatgActtgagagtagctgccattc	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:3129698A>G	ENST00000380266.3	-	2	340	c.19T>C	c.(19-21)Tca>Cca	p.S7P	UBOX5_ENST00000348031.2_Intron|UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	7					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						AGTTTTAATGACTTGAGAGTA	0.453													16	24					0	0	1	0	0	G	3129698	A	G	3129698	3	3	48	1	0	0	0	0	1	0	0	0	5720	275	10	4	2279	4	FASTKD5	20	3129698	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1815	3129698	59895822	4015	8409										
SIGLEC1	6614	broad.mit.edu	37	chr20	3680010	3680010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattcaggtaccaggagaagCgggcatcaggtgtggggctt	16	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:3680010C>T	ENST00000344754.4	-	7	1624	c.1625G>A	c.(1624-1626)cGc>cAc	p.R542H	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.R542H	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	542	Ig-like C2-type 5.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CCAGGAGAAGCGGGCATCAGG	0.672													14	10					0	0	1	0	0	T	3680010	C	T	3680010	3	4	48	1	0	0	0	0	1	0	0	0	14359	768	27	1	3564	1	SIGLEC1	20	3680010	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	550312	3680010	59345510	4016	8410										
PRNP	5621	broad.mit.edu	37	chr20	4680119	4680119	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggtggctggggacagcctCatggtggtggctggggtcaa	20	7	2	0	rs144328292		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:4680119C>A	ENST00000379440.4	+	2	540	c.253C>A	c.(253-255)Cat>Aat	p.H85N	PRNP_ENST00000430350.2_Missense_Mutation_p.H85N	NM_000311.3|NM_001080121.1|NM_001080122.1|NM_001080123.1|NM_001271561.1|NM_183079.2	NP_000302.1|NP_001073590.1|NP_001073591.1|NP_001073592.1|NP_001258490.1|NP_898902.1	P04156	PRIO_HUMAN	prion protein	85	5 X 8 AA tandem repeats of P-H-G-G-G-W-G- Q.|Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	14					Tetracycline(DB00759)	GGGACAGCCTCATGGTGGTGG	0.647													15	59					6.31663e-08	7.35827e-08	1	1	0	A	4680119	C	A	4680119	3	1	48	1	0	0	0	0	1	0	0	0	12595	826	29	2	255	2	PRNP	20	4680119	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1000109	4680119	58345401	4017	8411										
PRND	23627	broad.mit.edu	37	chr20	4705395	4705395	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcaagcaaggccgcaagctCgacattgacttcggagccga	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:4705395C>T	ENST00000305817.2	+	2	269	c.198C>T	c.(196-198)ctC>ctT	p.L66L		NM_012409.2	NP_036541.2	Q9UKY0	PRND_HUMAN	prion protein 2 (dublet)	66	Globular.				protein homooligomerization	anchored to membrane|plasma membrane				breast(3)|endometrium(2)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	13						GCCGCAAGCTCGACATTGACT	0.602													25	45					0	0	1	0	0	T	4705395	C	T	4705395	2	4	48	1	0	0	0	0	0	0	0	1	12594	871	31	1		1	PRND	20	4705395	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	25276	4705395	58320125	4018	8412										
RASSF2	9770	broad.mit.edu	37	chr20	4776603	4776603	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcccctccacaatgaactCgtcttcttcctgcccacaaa	5	17	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:4776603C>T	ENST00000379400.3	-	5	340	c.145G>A	c.(145-147)Gag>Aag	p.E49K	RASSF2_ENST00000379376.2_Missense_Mutation_p.E49K	NM_014737.2	NP_055552.1	P50749	RASF2_HUMAN	Ras association (RalGDS/AF-6) domain family member 2	49					cell cycle|signal transduction	nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|pancreas(2)|prostate(2)|skin(2)	34						ACAATGAACTCGTCTTCTTCC	0.552													6	49					0	0	1	0	0	T	4776603	C	T	4776603	3	4	48	1	0	0	0	0	1	0	0	0	13137	893	31	1	867	1	RASSF2	20	4776603	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	71208	4776603	58248917	4019	8413										
GPCPD1	56261	broad.mit.edu	37	chr20	5560680	5560680	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagatttttttaattttttCttggttattgacacaggagg	8	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:5560680C>A	ENST00000379019.4	-	7	659	c.447G>T	c.(445-447)aaG>aaT	p.K149N	GPCPD1_ENST00000481038.1_5'UTR	NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	149					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						TTAATTTTTTCTTGGTTATTG	0.338													13	21					2.27111e-07	2.60515e-07	1	1	0	A	5560680	C	A	5560680	3	1	48	1	0	0	0	0	1	0	0	0	6642	912	32	2	1627	2	GPCPD1	20	5560680	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	784077	5560680	57464840	4020	8414										
C20orf196	149840	broad.mit.edu	37	chr20	5843907	5843907	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaggccaggagagccaaaAgtatgccctccgcagttttc	11	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:5843907A>G	ENST00000303142.6	+	3	503	c.416A>G	c.(415-417)aAg>aGg	p.K139R		NM_152504.2	NP_689717.2	Q8IYI0	CT196_HUMAN	chromosome 20 open reading frame 196	139										endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)	9						GAGAGCCAAAAGTATGCCCTC	0.537													22	35					0	0	1	0	0	G	5843907	A	G	5843907	3	3	48	1	0	0	0	0	1	0	0	0	2115	72	3	4	422	4	C20orf196	20	5843907	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	283227	5843907	57181613	4021	8415										
CHGB	1114	broad.mit.edu	37	chr20	5904272	5904272	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacctgcaggacactaaagaAaacagggaggaagctaggtt	13	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:5904272A>C	ENST00000378961.4	+	4	1686	c.1482A>C	c.(1480-1482)gaA>gaC	p.E494D		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	494						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						ACACTAAAGAAAACAGGGAGG	0.488													34	50					0	0	1	0	0	C	5904272	A	C	5904272	3	2	48	1	0	0	0	0	1	0	0	0	3361	11	1	4	1496	4	CHGB	20	5904272	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	60365	5904272	57121248	4022	8416										
LRRN4	164312	broad.mit.edu	37	chr20	6022404	6022404	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctctggccgggctgaggcGagcttatgctgcggtcccac	14	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:6022404G>A	ENST00000378858.4	-	5	1711	c.1487C>T	c.(1486-1488)tCg>tTg	p.S496L		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	496						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						GGGCTGAGGCGAGCTTATGCT	0.637													61	93					0	0	1	0	0	A	6022404	G	A	6022404	3	1	48	1	0	0	0	0	1	0	0	0	9081	1059	37	1	739	1	LRRN4	20	6022404	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	118132	6022404	57003116	4023	8417										
FERMT1	55612	broad.mit.edu	37	chr20	6057898	6057898	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccttggagcgggtggacaaGaaaatgtagccgccaatgta	13	8	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:6057898G>T	ENST00000217289.4	-	15	2744	c.1956C>A	c.(1954-1956)ttC>ttA	p.F652L	FERMT1_ENST00000536936.1_Missense_Mutation_p.F395L|FERMT1_ENST00000478194.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	652	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						GGGTGGACAAGAAAATGTAGC	0.507											OREG0025763	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	47					1.2644e-06	1.4261e-06	1	1	0	T	6057898	G	T	6057898	3	4	48	1	0	0	0	0	1	0	0	0	5849	933	33	2	81	2	FERMT1	20	6057898	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	35494	6057898	56967622	4024	8418										
FERMT1	55612	broad.mit.edu	37	chr20	6069709	6069709	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagataaaccaatattgtttGaaagcttttggtagtaactt	7	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:6069709G>T	ENST00000217289.4	-	10	1955	c.1167C>A	c.(1165-1167)ttC>ttA	p.F389L	FERMT1_ENST00000536936.1_Missense_Mutation_p.F132L|FERMT1_ENST00000478194.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	389	FERM.|PH.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						AATATTGTTTGAAAGCTTTTG	0.353													5	48					5.9392e-07	6.75488e-07	1	1	0	T	6069709	G	T	6069709	3	4	48	1	0	0	0	0	1	0	0	0	5849	1281	45	2	890	2	FERMT1	20	6069709	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11811	6069709	56955811	4025	8419										
ISM1	140862	broad.mit.edu	37	chr20	13251302	13251302	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggcacccttcattgcaaaGagatttccccagatcctttc	8	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:13251302G>T	ENST00000262487.3	+	2	296	c.290G>T	c.(289-291)aGa>aTa	p.R97I	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	97						extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						TCATTGCAAAGAGATTTCCCC	0.498													12	32					1.08611e-07	1.25818e-07	1	1	0	T	13251302	G	T	13251302	3	4	48	1	0	0	0	0	1	0	0	0	7903	942	33	2	296	2	ISM1	20	13251302	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7181593	13251302	49774218	4026	8420										
ESF1	51575	broad.mit.edu	37	chr20	13755837	13755837	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacacctcctttgggtttaAatgaattgaacagagccagc	8	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:13755837A>C	ENST00000202816.1	-	4	1222	c.1115T>G	c.(1114-1116)tTt>tGt	p.F372C		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTTGGGTTTAAATGAATTGAA	0.308													35	61					0	0	1	0	0	C	13755837	A	C	13755837	3	2	48	1	0	0	0	0	1	0	0	0	5279	14	1	4	1484	4	ESF1	20	13755837	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	504535	13755837	49269683	4027	8421										
MACROD2	140733	broad.mit.edu	37	chr20	13982972	13982972	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttagaagagagacgcaaaGaatacctaagagactatatt	8	7	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:13982972G>T	ENST00000217246.4	+	2	480	c.85G>T	c.(85-87)Gaa>Taa	p.E29*	MACROD2_ENST00000310348.4_Nonsense_Mutation_p.E29*	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	29										breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GAGACGCAAAGAATACCTAAG	0.358													10	48					0.000673444	0.000709932	1	1	0	T	13982972	G	T	13982972	4	4	48	1	0	0	0	0	0	1	0	0	9191	943	33	2	91	2	MACROD2	20	13982972	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	227135	13982972	49042548	4028	8422										
KIF16B	55614	broad.mit.edu	37	chr20	16359822	16359822	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttccttttctacttgataaAgagtgttgtctaagctgaga	8	6	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:16359822A>C	ENST00000354981.2	-	19	2982	c.2825T>G	c.(2824-2826)cTt>cGt	p.L942R	KIF16B_ENST00000378003.2_Missense_Mutation_p.L168R|KIF16B_ENST00000355755.3_Missense_Mutation_p.L942R|KIF16B_ENST00000408042.1_Missense_Mutation_p.L942R	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	942	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TACTTGATAAAGAGTGTTGTC	0.438													39	81					0	0	1	0	0	C	16359822	A	C	16359822	3	2	48	1	0	0	0	0	1	0	0	0	8319	72	3	4	1160	4	KIF16B	20	16359822	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2376850	16359822	46665698	4029	8423										
RRBP1	6238	broad.mit.edu	37	chr20	17640992	17640992	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttcttctcgactttctggTggtgagttttcgccatctcc	8	11	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:17640992T>C	ENST00000377813.1	-	3	464	c.161A>G	c.(160-162)cAc>cGc	p.H54R	RRBP1_ENST00000377807.2_Missense_Mutation_p.H54R|RRBP1_ENST00000360807.4_Missense_Mutation_p.H54R|RRBP1_ENST00000246043.4_Missense_Mutation_p.H54R|RRBP1_ENST00000455029.2_Intron			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	54					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						GACTTTCTGGTGGTGAGTTTT	0.448													3	22					0	0	1	0	0	C	17640992	T	C	17640992	3	2	48	1	0	0	0	0	1	0	0	0	13729	1696	59	4	2868	4	RRBP1	20	17640992	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1281170	17640992	45384528	4030	8424										
ZNF133	7692	broad.mit.edu	37	chr20	18296758	18296758	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgggcacagcttcagccaGaattcaaccctcatctctca	7	14	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:18296758G>T	ENST00000377671.3	+	7	1819	c.1260G>T	c.(1258-1260)caG>caT	p.Q420H	ZNF133_ENST00000401790.1_Missense_Mutation_p.Q421H|ZNF133_ENST00000535822.1_Missense_Mutation_p.Q326H|ZNF133_ENST00000538547.1_Missense_Mutation_p.Q326H|ZNF133_ENST00000316358.4_Missense_Mutation_p.Q421H|ZNF133_ENST00000402618.2_Missense_Mutation_p.Q358H|ZNF133_ENST00000396026.3_Missense_Mutation_p.Q424H|ZNF133_ENST00000462170.1_3'UTR	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	421						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						GCTTCAGCCAGAATTCAACCC	0.562													42	81					6.45866e-13	8.20724e-13	1	1	0	T	18296758	G	T	18296758	3	4	48	1	0	0	0	0	1	0	0	0	17780	933	33	2	1270	2	ZNF133	20	18296758	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	655766	18296758	44728762	4031	8425										
C20orf26	26074	broad.mit.edu	37	chr20	20177339	20177339	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attttccggcactacaccaaGttctttctgaaggagatcct	7	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:20177339G>A	ENST00000245957.5	+	16	1792	c.1716G>A	c.(1714-1716)aaG>aaA	p.K572K	C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	572										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ACTACACCAAGTTCTTTCTGA	0.458													26	44					0	0	1	0	0	A	20177339	G	A	20177339	2	1	48	1	0	0	0	0	0	0	0	1	2120	1020	36	3		3	C20orf26	20	20177339	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1880581	20177339	42848181	4032	8426										
CST8	10047	broad.mit.edu	37	chr20	23472478	23472478	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccatgcaagaatacaacaaAgagagcgaggacaagtatgt	11	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:23472478A>C	ENST00000246012.1	+	2	531	c.174A>C	c.(172-174)aaA>aaC	p.K58N		NM_005492.2	NP_005483.1	O60676	CST8_HUMAN	cystatin 8 (cystatin-related epididymal specific)	58						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(9)|skin(2)	16	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AATACAACAAAGAGAGCGAGG	0.463													49	95					0	0	1	0	0	C	23472478	A	C	23472478	3	2	48	1	0	0	0	0	1	0	0	0	4003	69	3	4	176	4	CST8	20	23472478	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3295139	23472478	39553042	4033	8427										
GGTLC1	92086	broad.mit.edu	37	chr20	23967198	23967198	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taggagatcgggtgagtggtGtcgtcagagatctgggcccg	18	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:23967198G>A	ENST00000335694.4	-	2	255	c.51C>T	c.(49-51)gaC>gaT	p.D17D	GGTLC1_ENST00000278765.4_Silent_p.D17D|GGTLC1_ENST00000286890.4_Silent_p.D17D	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	17							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						GGTGAGTGGTGTCGTCAGAGA	0.632													24	67					0	0	1	0	0	A	23967198	G	A	23967198	2	1	48	1	0	0	0	0	0	0	0	1	6406	1368	48	3		3	GGTLC1	20	23967198	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	494720	23967198	39058322	4034	8428										
GINS1	9837	broad.mit.edu	37	chr20	25405867	25405868	+	Frame_Shift_Ins	INS	-	-	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggagtggtttaataattatINSaaaagatctcttgctactta							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:25405867_25405868insA	ENST00000262460.4	+	5	445_446	c.351_352insA	c.(349-354)taaaagfs	p.*K117fs	GINS1_ENST00000429262.2_Frame_Shift_Ins_p.K158fs	NM_021067.3	NP_066545.3	Q14691	PSF1_HUMAN	GINS complex subunit 1 (Psf1 homolog)	117					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	7						TTAATAATTATAAAAGATCTCT	0.347													17	26	---	---	---	---						A	25405868	-	A	25405867	7	5	48	1	0	1	1	0	0	0	0	0	6428	1413	49	0	369	0	GINS1	20	25405867	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	1438669	25405867	37619653	4035	8429										
ZNF337	26152	broad.mit.edu	37	chr20	25656309	25656309	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catgaagggcttctctcctgAgtgtgtcctctgatgtatgg	12	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:25656309A>G	ENST00000376436.1	-	4	2154	c.1615T>C	c.(1615-1617)Tca>Cca	p.S539P	ZNF337_ENST00000252979.5_Missense_Mutation_p.S539P|RP4-694B14.5_ENST00000455791.1_RNA|RP4-694B14.5_ENST00000414393.1_RNA|RP4-694B14.5_ENST00000439498.1_RNA|ZNF337_ENST00000538750.1_Missense_Mutation_p.S507P					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTCTCTCCTGAGTGTGTCCTC	0.483													27	58					0	0	1	0	0	G	25656309	A	G	25656309	3	3	48	1	0	0	0	0	1	0	0	0	17909	304	11	4	644	4	ZNF337	20	25656309	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	250442	25656309	37369211	4036	8430										
ZNF337	26152	broad.mit.edu	37	chr20	25656432	25656432	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttataggaggacttatcccGaaaccttcgcccacactccc	7	15	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:25656432G>A	ENST00000376436.1	-	4	2031	c.1492C>T	c.(1492-1494)Cgg>Tgg	p.R498W	ZNF337_ENST00000252979.5_Missense_Mutation_p.R498W|RP4-694B14.5_ENST00000455791.1_RNA|RP4-694B14.5_ENST00000414393.1_RNA|RP4-694B14.5_ENST00000439498.1_RNA|ZNF337_ENST00000538750.1_Missense_Mutation_p.R466W					zinc finger protein 337									p.R498W(1)		breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GACTTATCCCGAAACCTTCGC	0.498													46	77					0	0	1	0	0	A	25656432	G	A	25656432	3	1	48	1	0	0	0	0	1	0	0	0	17909	1057	37	1	767	1	ZNF337	20	25656432	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	123	25656432	37369088	4037	8431										
DEFB118	117285	broad.mit.edu	37	chr20	29960797	29960797	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaagaccacaggcgagttCctgcgacatctcccacaccc	8	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:29960797C>A	ENST00000253381.2	+	2	229	c.196C>A	c.(196-198)Cct>Act	p.P66T		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	66					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CAGGCGAGTTCCTGCGACATC	0.438													38	79					3.33393e-15	4.38315e-15	1	1	0	A	29960797	C	A	29960797	3	1	48	1	0	0	0	0	1	0	0	0	4433	855	30	2	202	2	DEFB118	20	29960797	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4304365	29960797	33064723	4038	8432										
HCK	3055	broad.mit.edu	37	chr20	30689247	30689247	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaccgtccggaggagcggccGaccttcgaatacatccagag	12	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:30689247G>A	ENST00000534862.1	+	14	1809	c.1446G>A	c.(1444-1446)ccG>ccA	p.P482P	HCK_ENST00000375852.2_Silent_p.P502P|HCK_ENST00000518730.1_Silent_p.P480P|HCK_ENST00000375862.2_Silent_p.P501P|HCK_ENST00000520553.1_Silent_p.P481P|HCK_ENST00000538448.1_Silent_p.P481P	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	502	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGGAGCGGCCGACCTTCGAAT	0.592													6	18					0	0	1	0	0	A	30689247	G	A	30689247	2	1	48	1	0	0	0	0	0	0	0	1	7034	1045	37	1		1	HCK	20	30689247	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	728450	30689247	32336273	4039	8433										
POFUT1	23509	broad.mit.edu	37	chr20	30797902	30797902	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggaaccaggccgatcacttCttgggctctctggcatttgc	12	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:30797902C>A	ENST00000375749.3	+	2	215	c.153C>A	c.(151-153)ttC>ttA	p.F51L	POFUT1_ENST00000375730.3_Missense_Mutation_p.F51L|POFUT1_ENST00000539210.1_Intron|POFUT1_ENST00000486717.1_Intron	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	51					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCGATCACTTCTTGGGCTCTC	0.552													7	129					8.12818e-05	8.79784e-05	1	1	0	A	30797902	C	A	30797902	3	1	48	1	0	0	0	0	1	0	0	0	12230	912	32	2	159	2	POFUT1	20	30797902	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	108655	30797902	32227618	4040	8434										
KIF3B	9371	broad.mit.edu	37	chr20	30898040	30898040	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctaccaggaggagatccgaGatttgctctcaaaggatcag	11	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:30898040G>T	ENST00000375712.3	+	2	627	c.460G>T	c.(460-462)Gat>Tat	p.D154Y		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	154	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGAGATCCGAGATTTGCTCTC	0.458													10	44					2.17888e-05	2.39107e-05	1	1	0	T	30898040	G	T	30898040	3	4	48	1	0	0	0	0	1	0	0	0	8342	942	33	2	462	2	KIF3B	20	30898040	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	100138	30898040	32127480	4041	8435										
ASXL1	171023	broad.mit.edu	37	chr20	31021321	31021321	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggttgctaaggatgcaaaAtctgtggcctcagatgttcc	13	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:31021321A>C	ENST00000375687.4	+	12	1744	c.1320A>C	c.(1318-1320)aaA>aaC	p.K440N	ASXL1_ENST00000306058.5_Missense_Mutation_p.K435N	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	440					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AGGATGCAAAATCTGTGGCCT	0.527			"F, N, Mis"		"MDS, CMML"								5	110					0	0	1	0	0	C	31021321	A	C	31021321	3	2	48	1	0	0	0	0	1	0	0	0	1065	98	4	4	1372	4	ASXL1	20	31021321	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	123281	31021321	32004199	4042	8436										
MAPRE1	22919	broad.mit.edu	37	chr20	31424467	31424467	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtggacaaattagtaaaaGgaaagtttcaggacaatttt	9	4	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:31424467G>T	ENST00000375571.5	+	4	434	c.295G>T	c.(295-297)Gga>Tga	p.G99*		NM_012325.2	NP_036457.1	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family, member 1	99	CH.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8						ATTAGTAAAAGGAAAGTTTCA	0.393													11	30					2.27111e-07	2.60515e-07	1	1	0	T	31424467	G	T	31424467	4	4	48	1	0	0	0	0	0	1	0	0	9343	1001	35	5	305	5	MAPRE1	20	31424467	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	403146	31424467	31601053	4043	8437										
ITCH	83737	broad.mit.edu	37	chr20	33080315	33080315	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttttaacagtttgttaaaGaaattgataatgagaagaga	8	2	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:33080315G>T	ENST00000374864.4	+	23	2542	c.2329G>T	c.(2329-2331)Gaa>Taa	p.E777*	ITCH_ENST00000535650.1_Nonsense_Mutation_p.E667*|ITCH_ENST00000262650.6_Nonsense_Mutation_p.E818*	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	818	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GTTTGTTAAAGAAATTGATAA	0.318													16	37					1.99824e-07	2.29918e-07	1	1	0	T	33080315	G	T	33080315	4	4	48	1	0	0	0	0	0	1	0	0	7911	943	33	2	2411	2	ITCH	20	33080315	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1655848	33080315	29945205	4044	8438										
ITCH	83737	broad.mit.edu	37	chr20	33092154	33092154	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggagcaatggaccacagaAattctgcattgaaaaagttg	11	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:33092154A>C	ENST00000374864.4	+	24	2648	c.2435A>C	c.(2434-2436)aAa>aCa	p.K812T	ITCH_ENST00000535650.1_Missense_Mutation_p.K702T|ITCH_ENST00000262650.6_Missense_Mutation_p.K853T	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	853	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GGACCACAGAAATTCTGCATT	0.378													10	25					0	0	1	0	0	C	33092154	A	C	33092154	3	2	48	1	0	0	0	0	1	0	0	0	7911	14	1	4	2521	4	ITCH	20	33092154	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	11839	33092154	29933366	4045	8439										
DYNLRB1	83658	broad.mit.edu	37	chr20	33122566	33122566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atctcaccttccttcgaattCgctccaagaaaaatgaaatt	4	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:33122566C>T	ENST00000417166.2	+	3	247	c.214C>T	c.(214-216)Cgc>Tgc	p.R72C	DYNLRB1_ENST00000357156.2_Missense_Mutation_p.R72C|DYNLRB1_ENST00000480759.1_3'UTR|DYNLRB1_ENST00000374846.3_Missense_Mutation_p.R124C			Q9NP97	DLRB1_HUMAN	dynein, light chain, roadblock-type 1	72					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity	p.R72C(1)		endometrium(1)|large_intestine(1)|lung(1)	3						CCTTCGAATTCGCTCCAAGAA	0.527													31	48					0	0	1	0	0	T	33122566	C	T	33122566	3	4	48	1	0	0	0	0	1	0	0	0	4876	884	31	1	224	1	DYNLRB1	20	33122566	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	30412	33122566	29902954	4046	8440										
EIF6	3692	broad.mit.edu	37	chr20	33867534	33867534	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagcaatcacctcactgcctCggttcacagtccccgcctgc	7	19	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:33867534C>T	ENST00000374450.3	-	6	827	c.563G>A	c.(562-564)cGa>cAa	p.R188Q	EIF6_ENST00000374436.3_Missense_Mutation_p.R188Q|EIF6_ENST00000374443.3_Missense_Mutation_p.R169Q|RP4-614O4.11_ENST00000444717.1_RNA	NM_002212.3	NP_002203.1	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	188					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTCACTGCCTCGGTTCACAGT	0.577													23	91					0	0	1	0	0	T	33867534	C	T	33867534	3	4	48	1	0	0	0	0	1	0	0	0	5073	884	31	1	182	1	EIF6	20	33867534	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	744968	33867534	29157986	4047	8441										
CEP250	11190	broad.mit.edu	37	chr20	34091280	34091280	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaagctgtccttgagagagCgaggccgggagctgaccact	14	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:34091280C>T	ENST00000397527.1	+	30	5803	c.5083C>T	c.(5083-5085)Cga>Tga	p.R1695*	CEP250_ENST00000342580.4_Nonsense_Mutation_p.R1639*	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1695	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTTGAGAGAGCGAGGCCGGGA	0.592													52	99					0	0	1	0	0	T	34091280	C	T	34091280	4	4	48	1	0	0	0	0	0	1	0	0	3274	760	27	1	5189	1	CEP250	20	34091280	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	223746	34091280	28934240	4048	8442										
RBM12	10137	broad.mit.edu	37	chr20	34241692	34241692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaagttctgcagtctttttCgaatcatatctatcttttct	5	8	6	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:34241692C>T	ENST00000374114.3	-	3	1816	c.1553G>A	c.(1552-1554)cGa>cAa	p.R518Q	CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000317619.3_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.R518Q|RBM12_ENST00000359646.1_Missense_Mutation_p.R518Q	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	518						nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CAGTCTTTTTCGAATCATATC	0.398													61	115					0	0	1	0	0	T	34241692	C	T	34241692	3	4	48	1	0	0	0	0	1	0	0	0	13164	884	31	1	1249	1	RBM12	20	34241692	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	150412	34241692	28783828	4049	8443										
DSN1	79980	broad.mit.edu	37	chr20	35399573	35399573	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccaattgatgatcatgagTcttagacatcactggtcctt	7	9	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:35399573T>C	ENST00000426836.1	-	3	430	c.58A>G	c.(58-60)Act>Gct	p.T20A	DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000448110.1_Missense_Mutation_p.T4A|DSN1_ENST00000373740.3_Intron|DSN1_ENST00000373745.3_Missense_Mutation_p.T20A|DSN1_ENST00000373734.4_Intron|DSN1_ENST00000373750.4_Missense_Mutation_p.T20A	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	20					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TGATCATGAGTCTTAGACATC	0.378													47	93					0	0	1	0	0	C	35399573	T	C	35399573	3	2	48	1	0	0	0	0	1	0	0	0	4806	1667	58	4	1048	4	DSN1	20	35399573	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1157881	35399573	27625947	4050	8444										
CTNNBL1	56259	broad.mit.edu	37	chr20	36488328	36488328	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccggcgaggagagatcatcGacaatgacaccgaggaggag	15	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:36488328G>A	ENST00000405275.2	+	15	1582	c.1339G>A	c.(1339-1341)Gac>Aac	p.D447N	CTNNBL1_ENST00000373473.1_Missense_Mutation_p.D287N|CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.D222N|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.D474N			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	474					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				AGAGATCATCGACAATGACAC	0.517													14	21					0	0	1	0	0	A	36488328	G	A	36488328	3	1	48	1	0	0	0	0	1	0	0	0	4042	1058	37	1	1474	1	CTNNBL1	20	36488328	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1088755	36488328	26537192	4051	8445										
KIAA1755	85449	broad.mit.edu	37	chr20	36874470	36874470	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggtgggtgctgtggcctcgAaaggaggatagaggcccgcc	18	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:36874470A>G	ENST00000279024.4	-	2	333	c.62T>C	c.(61-63)tTc>tCc	p.F21S		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	21										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				TGTGGCCTCGAAAGGAGGATA	0.597													18	29					0	0	1	0	0	G	36874470	A	G	36874470	3	3	48	1	0	0	0	0	1	0	0	0	8298	246	9	4	3592	4	KIAA1755	20	36874470	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	386142	36874470	26151050	4052	8446										
BPI	671	broad.mit.edu	37	chr20	36938940	36938940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catagaaggcatgtccatttCggctgatctgaagctgggca	12	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:36938940C>T	ENST00000262865.4	+	4	523	c.434C>T	c.(433-435)tCg>tTg	p.S145L	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	145					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				ATGTCCATTTCGGCTGATCTG	0.507													25	42					0	0	1	0	0	T	36938940	C	T	36938940	3	4	48	1	0	0	0	0	1	0	0	0	1492	893	31	1	448	1	BPI	20	36938940	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	64470	36938940	26086580	4053	8447										
LBP	3929	broad.mit.edu	37	chr20	36999943	36999943	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtaaaagtggaactgaaaGaatccaaagttggactattc	11	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:36999943G>T	ENST00000217407.2	+	12	1398	c.1237G>T	c.(1237-1239)Gaa>Taa	p.E413*		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	413					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GGAACTGAAAGAATCCAAAGT	0.383													4	29					0.150653	0.151842	1	1	0	T	36999943	G	T	36999943	4	4	48	1	0	0	0	0	0	1	0	0	8689	943	33	2	1283	2	LBP	20	36999943	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	61003	36999943	26025577	4054	8448										
SLC32A1	140679	broad.mit.edu	37	chr20	37356342	37356342	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacgtagcgcagatcatcgAgctggtgatgacgtgcatcc	13	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:37356342A>G	ENST00000217420.1	+	2	901	c.638A>G	c.(637-639)gAg>gGg	p.E213G		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	213					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CAGATCATCGAGCTGGTGATG	0.632													5	63					0	0	1	0	0	G	37356342	A	G	37356342	3	3	48	1	0	0	0	0	1	0	0	0	14619	304	11	4	644	4	SLC32A1	20	37356342	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	356399	37356342	25669178	4055	8449										
PPP1R16B	26051	broad.mit.edu	37	chr20	37547186	37547186	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcggaggcagaacttcaccGtacagcagcaatgggacctc	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:37547186G>A	ENST00000299824.1	+	11	1770	c.1581G>A	c.(1579-1581)ccG>ccA	p.P527P	PPP1R16B_ENST00000373331.2_Silent_p.P485P	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	527					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				GAACTTCACCGTACAGCAGCA	0.587													18	43					0	0	1	0	0	A	37547186	G	A	37547186	2	1	48	1	0	0	0	0	0	0	0	1	12414	1132	40	1		1	PPP1R16B	20	37547186	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	190844	37547186	25478334	4056	8450										
DHX35	60625	broad.mit.edu	37	chr20	37601234	37601234	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attttatacttgatagaaaaTtatcagacagtggtgattgt	8	3	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:37601234T>C	ENST00000252011.3	+	3	240	c.207T>C	c.(205-207)aaT>aaC	p.N69N	DHX35_ENST00000373323.4_Intron|DHX35_ENST00000373325.2_Silent_p.N69N	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	69	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				TGATAGAAAATTATCAGACAG	0.343													9	19					0	0	1	0	0	C	37601234	T	C	37601234	2	2	48	1	0	0	0	0	0	0	0	1	4536	1490	52	4		4	DHX35	20	37601234	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	54048	37601234	25424286	4057	8451										
DHX35	60625	broad.mit.edu	37	chr20	37621001	37621001	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctctttgattcttagtgTcatcatgctggatgaagccc	8	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:37621001T>C	ENST00000252011.3	+	7	548	c.515T>C	c.(514-516)gTc>gCc	p.V172A	DHX35_ENST00000373323.4_Missense_Mutation_p.V141A|DHX35_ENST00000373325.2_Missense_Mutation_p.V172A	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	172	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				ATTCTTAGTGTCATCATGCTG	0.433													19	35					0	0	1	0	0	C	37621001	T	C	37621001	3	2	48	1	0	0	0	0	1	0	0	0	4536	1667	58	4	541	4	DHX35	20	37621001	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	19767	37621001	25404519	4058	8452										
PLCG1	5335	broad.mit.edu	37	chr20	39800865	39800865	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagataatggaacggaggaaGaagattgccctggagctctc	13	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:39800865G>A	ENST00000373272.2	+	25	3246	c.2841G>A	c.(2839-2841)aaG>aaA	p.K947K	PLCG1_ENST00000244007.3_Silent_p.K947K|PLCG1_ENST00000373271.1_Silent_p.K947K	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	947					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				AACGGAGGAAGAAGATTGCCC	0.592													27	177					0	0	1	0	0	A	39800865	G	A	39800865	2	1	48	1	0	0	0	0	0	0	0	1	12082	933	33	3		3	PLCG1	20	39800865	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2179864	39800865	23224655	4059	8453										
PTPRT	11122	broad.mit.edu	37	chr20	40827896	40827896	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttactgaatccgttgacgtcCtgagaactagaagagaagcc	10	9	0	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:40827896C>T	ENST00000373198.3	-	17	2776	c.2541G>A	c.(2539-2541)caG>caA	p.Q847Q	PTPRT_ENST00000373193.3_Silent_p.Q828Q|PTPRT_ENST00000373184.1_Silent_p.Q815Q|PTPRT_ENST00000356100.2_Silent_p.Q834Q|PTPRT_ENST00000373190.1_Silent_p.Q825Q|PTPRT_ENST00000373187.1_Silent_p.Q825Q|PTPRT_ENST00000373201.1_Silent_p.Q815Q	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	825					homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CGTTGACGTCCTGAGAACTAG	0.567													155	348					0	0	1	0	0	T	40827896	C	T	40827896	2	4	48	1	0	0	0	0	0	0	0	1	12863	680	24	3		3	PTPRT	20	40827896	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1027031	40827896	22197624	4060	8454										
PTPRT	11122	broad.mit.edu	37	chr20	40944562	40944562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccgatagctcacgggcaccGaaaagcactcaataatgtca	8	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:40944562G>A	ENST00000373198.3	-	12	2175	c.1940C>T	c.(1939-1941)tCg>tTg	p.S647L	PTPRT_ENST00000373193.3_Missense_Mutation_p.S647L|PTPRT_ENST00000373184.1_Missense_Mutation_p.S647L|PTPRT_ENST00000356100.2_Missense_Mutation_p.S647L|PTPRT_ENST00000373190.1_Missense_Mutation_p.S647L|PTPRT_ENST00000373187.1_Missense_Mutation_p.S647L|PTPRT_ENST00000373201.1_Missense_Mutation_p.S647L	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	647	Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CACGGGCACCGAAAAGCACTC	0.517													51	78					0	0	1	0	0	A	40944562	G	A	40944562	3	1	48	1	0	0	0	0	1	0	0	0	12863	1059	37	1	2526	1	PTPRT	20	40944562	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	116666	40944562	22080958	4061	8455										
SGK2	10110	broad.mit.edu	37	chr20	42203567	42203567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtacttggcacctgaagtgCttcggaaagagccttatgat	11	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:42203567C>T	ENST00000373100.1	+	11	1076	c.616C>T	c.(616-618)Ctt>Ttt	p.L206F	SGK2_ENST00000373092.3_Missense_Mutation_p.L206F|SGK2_ENST00000373077.1_Missense_Mutation_p.L205F|SGK2_ENST00000423407.3_Missense_Mutation_p.L206F|SGK2_ENST00000426287.1_Missense_Mutation_p.L232F|SGK2_ENST00000341458.4_Missense_Mutation_p.L266F			Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2	266	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACCTGAAGTGCTTCGGAAAGA	0.502													22	23					0	0	1	0	0	T	42203567	C	T	42203567	3	4	48	1	0	0	0	0	1	0	0	0	14262	797	28	3	830	3	SGK2	20	42203567	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1259005	42203567	20821953	4062	8456										
KCNK15	60598	broad.mit.edu	37	chr20	43378957	43378957	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggacgtgcgtgtccacggaGaacctggtggtggccgggct	18	10	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:43378957G>T	ENST00000372861.3	+	2	602	c.471G>T	c.(469-471)gaG>gaT	p.E157D		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	157						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				TGTCCACGGAGAACCTGGTGG	0.701													15	8					1.49906e-05	1.64923e-05	1	1	0	T	43378957	G	T	43378957	3	4	48	1	0	0	0	0	1	0	0	0	8105	933	33	2	477	2	KCNK15	20	43378957	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1175390	43378957	19646563	4063	8457										
STK4	6789	broad.mit.edu	37	chr20	43653766	43653766	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccacaggatggagactacGagtttgtaagtagtgttgga	13	5	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:43653766G>A	ENST00000372806.3	+	10	1395	c.1300G>A	c.(1300-1302)Gag>Aag	p.E434K	STK4_ENST00000372801.1_Missense_Mutation_p.E434K|STK4_ENST00000499879.2_Missense_Mutation_p.E379K|STK4_ENST00000396731.4_Missense_Mutation_p.E434K	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	434	SARAH.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				TGGAGACTACGAGTTTGTAAG	0.378													12	37					0	0	1	0	0	A	43653766	G	A	43653766	3	1	48	1	0	0	0	0	1	0	0	0	15361	1059	37	1	1338	1	STK4	20	43653766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	274809	43653766	19371754	4064	8458										
SEMG1	6406	broad.mit.edu	37	chr20	43836602	43836602	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaataaagggcattaccaaAatgtggttgaagtgagagag	12	3	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:43836602A>C	ENST00000372781.3	+	2	721	c.664A>C	c.(664-666)Aat>Cat	p.N222H	SEMG1_ENST00000244069.6_Missense_Mutation_p.N222H	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GCATTACCAAAATGTGGTTGA	0.398													34	64					0	0	1	0	0	C	43836602	A	C	43836602	3	2	48	1	0	0	0	0	1	0	0	0	14097	14	1	4	670	4	SEMG1	20	43836602	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	182836	43836602	19188918	4065	8459										
SEMG2	6407	broad.mit.edu	37	chr20	43851032	43851032	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caacatggacccaaagacatTtttactacccaagatgagct	6	11	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:43851032T>G	ENST00000372769.3	+	2	849	c.759T>G	c.(757-759)atT>atG	p.I253M		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	253	Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				CCAAAGACATTTTTACTACCC	0.403													38	73					0	0	1	0	0	G	43851032	T	G	43851032	3	3	48	1	0	0	0	0	1	0	0	0	14098	1829	64	4	765	4	SEMG2	20	43851032	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	14430	43851032	19174488	4066	8460										
SNX21	90203	broad.mit.edu	37	chr20	44469369	44469369	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggactttgagcggctgcaccGaaacctgcagcggcaattcc	12	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:44469369G>A	ENST00000372542.1	+	3	824	c.512G>A	c.(511-513)cGa>cAa	p.R171Q	SNX21_ENST00000344780.4_3'UTR|SNX21_ENST00000462307.1_3'UTR|SNX21_ENST00000372541.1_3'UTR|SNX21_ENST00000491381.1_Missense_Mutation_p.R180Q|SNX21_ENST00000342644.5_Missense_Mutation_p.R180Q			Q969T3	SNX21_HUMAN	sorting nexin family member 21	180	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|pancreas(1)	7		Myeloproliferative disorder(115;0.0122)				CGGCTGCACCGAAACCTGCAG	0.637													50	126					0	0	1	0	0	A	44469369	G	A	44469369	3	1	48	1	0	0	0	0	1	0	0	0	14946	1058	37	1	568	1	SNX21	20	44469369	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	618337	44469369	18556151	4067	8461										
MMP9	4318	broad.mit.edu	37	chr20	44639584	44639584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acggagacgggtatcccttcGacgggaaggacgggctcctg	16	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:44639584G>A	ENST00000372330.3	+	4	563	c.544G>A	c.(544-546)Gac>Aac	p.D182N		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	182					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GTATCCCTTCGACGGGAAGGA	0.622													33	55					0	0	1	0	0	A	44639584	G	A	44639584	3	1	48	1	0	0	0	0	1	0	0	0	9717	1058	37	1	558	1	MMP9	20	44639584	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	170215	44639584	18385936	4068	8462										
SLC12A5	57468	broad.mit.edu	37	chr20	44671793	44671793	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcattctgtctccccacagaGaacctctggagctcctacct	7	16	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:44671793G>T	ENST00000454036.1	+	9	1213	c.1135_splice	c.e9-1	p.E379_splice	SLC12A5_ENST00000243964.3_Splice_Site_p.E356_splice|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	379					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCCCACAGAGAACCTCTGGA	0.607													7	217					0.248553	0.24944	1	1	0	T	44671793	G	T	44671793	5	4	48	1	0	0	0	0	0	0	1	0	14440	956	33	2	1227	2	SLC12A5	20	44671793	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	32209	44671793	18353727	4069	8463										
CDH22	64405	broad.mit.edu	37	chr20	44803550	44803550	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgccgcccttgagctcgccGaagtcgtagaggctccgcag	13	15	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:44803550G>A	ENST00000372262.3	-	11	2482	c.2082C>T	c.(2080-2082)ttC>ttT	p.F694F	CDH22_ENST00000537909.1_Silent_p.F694F	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	694					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TGAGCTCGCCGAAGTCGTAGA	0.731													3	17					0	0	1	0	0	A	44803550	G	A	44803550	2	1	48	1	0	0	0	0	0	0	0	1	3129	1049	37	1		1	CDH22	20	44803550	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	131757	44803550	18221970	4070	8464										
ZNF334	55713	broad.mit.edu	37	chr20	45130994	45130994	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgacttccgaaaaaaggtCtttccacattcattacactc	5	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:45130994C>A	ENST00000457685.2	-	6	2193	c.870G>T	c.(868-870)aaG>aaT	p.K290N	ZNF334_ENST00000347606.4_Missense_Mutation_p.K328N|ZNF334_ENST00000593880.1_Missense_Mutation_p.K351N			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GAAAAAAGGTCTTTCCACATT	0.438													4	107					0.184627	0.185817	1	1	0	A	45130994	C	A	45130994	3	1	48	1	0	0	0	0	1	0	0	0	17907	912	32	2	1062	2	ZNF334	20	45130994	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	327444	45130994	17894526	4071	8465										
SLC13A3	64849	broad.mit.edu	37	chr20	45194982	45194982	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccagggcggggggcacattCtccagggggtgcagctgccc	18	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:45194982C>A	ENST00000279027.4	-	11	1398	c.1380G>T	c.(1378-1380)gaG>gaT	p.E460D	SLC13A3_ENST00000472148.1_Missense_Mutation_p.E378D|SLC13A3_ENST00000435032.1_Missense_Mutation_p.E45D|SLC13A3_ENST00000495082.1_Missense_Mutation_p.E413D|SLC13A3_ENST00000290317.5_Missense_Mutation_p.E413D|SLC13A3_ENST00000413164.2_Missense_Mutation_p.E410D|SLC13A3_ENST00000396360.1_Missense_Mutation_p.E378D	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	460						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GGGGCACATTCTCCAGGGGGT	0.617													43	95					1.41504e-22	1.969e-22	1	1	0	A	45194982	C	A	45194982	3	1	48	1	0	0	0	0	1	0	0	0	14447	912	32	2	440	2	SLC13A3	20	45194982	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	63988	45194982	17830538	4072	8466										
SLC2A10	81031	broad.mit.edu	37	chr20	45362452	45362452	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcatcccgtacagccgcatCgagatctctgcggcctcctg	11	16	1	1	rs148470005	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:45362452C>T	ENST00000359271.2	+	5	1855	c.1605C>T	c.(1603-1605)atC>atT	p.I535I		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	535						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				ACAGCCGCATCGAGATCTCTG	0.592													30	45					0	0	1	0	0	T	45362452	C	T	45362452	2	4	48	1	0	0	0	0	0	0	0	1	14593	874	31	1		1	SLC2A10	20	45362452	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	167470	45362452	17663068	4073	8467										
ZMYND8	23613	broad.mit.edu	37	chr20	45853141	45853141	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctccaactccagctgctTcttcacctcggcgatgagcc	7	17	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:45853141T>C	ENST00000311275.7	-	19	3278	c.3025A>G	c.(3025-3027)Aag>Gag	p.K1009E	ZMYND8_ENST00000355972.4_Missense_Mutation_p.K1009E|ZMYND8_ENST00000352431.2_Missense_Mutation_p.K983E|ZMYND8_ENST00000540497.1_Missense_Mutation_p.K957E|ZMYND8_ENST00000360911.3_Missense_Mutation_p.K958E|ZMYND8_ENST00000536340.1_Missense_Mutation_p.K1036E|ZMYND8_ENST00000446994.2_Missense_Mutation_p.K900E|ZMYND8_ENST00000458360.2_Missense_Mutation_p.K877E|ZMYND8_ENST00000372023.3_Missense_Mutation_p.K931E|ZMYND8_ENST00000262975.4_Missense_Mutation_p.K963E|ZMYND8_ENST00000461685.1_Missense_Mutation_p.K983E|ZMYND8_ENST00000471951.2_Missense_Mutation_p.K1029E|ZMYND8_ENST00000396281.4_Missense_Mutation_p.K1009E			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1009							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCCAGCTGCTTCTTCACCTCG	0.592													60	110					0	0	1	0	0	C	45853141	T	C	45853141	3	2	48	1	0	0	0	0	1	0	0	0	17768	1792	62	4	639	4	ZMYND8	20	45853141	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	490689	45853141	17172379	4074	8468										
ARFGEF2	10564	broad.mit.edu	37	chr20	47630161	47630161	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtgacagagtctgggtcCgaggctggttccccatctta	13	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:47630161C>T	ENST00000371917.4	+	29	3979	c.3979C>T	c.(3979-3981)Cga>Tga	p.R1327*		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1327					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGTCTGGGTCCGAGGCTGGTT	0.458													32	46					0	0	1	0	0	T	47630161	C	T	47630161	4	4	48	1	0	0	0	0	0	1	0	0	850	644	23	1	4093	1	ARFGEF2	20	47630161	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1777020	47630161	15395359	4075	8469										
ARFGEF2	10564	broad.mit.edu	37	chr20	47649561	47649561	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctctcccacctcaagtTcaaagcacatgcttcaatgt	5	13	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:47649561T>C	ENST00000371917.4	+	39	5183	c.5181_splice	c.e39-1	p.F1728_splice		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1728					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CACCTCAAGTTCAAAGCACAT	0.403													16	28					0	0	1	0	0	C	47649561	T	C	47649561	5	2	48	1	0	0	0	0	0	0	1	0	850	1797	62	4	5337	4	ARFGEF2	20	47649561	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	19400	47649561	15375959	4076	8470										
STAU1	6780	broad.mit.edu	37	chr20	47733749	47733749	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgataagagatacaaattCgttcttgttgtttttgggga	10	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:47733749C>T	ENST00000371828.3	-	12	1808	c.1321G>A	c.(1321-1323)Gaa>Aaa	p.E441K	STAU1_ENST00000340954.7_Missense_Mutation_p.E435K|STAU1_ENST00000371802.1_Missense_Mutation_p.E441K|STAU1_ENST00000371792.1_Missense_Mutation_p.E433K|STAU1_ENST00000371856.2_Missense_Mutation_p.E516K|STAU1_ENST00000347458.5_Missense_Mutation_p.E435K|STAU1_ENST00000360426.4_Missense_Mutation_p.E435K	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	516						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			GATACAAATTCGTTCTTGTTG	0.483													39	56					0	0	1	0	0	T	47733749	C	T	47733749	3	4	48	1	0	0	0	0	1	0	0	0	15327	893	31	1	199	1	STAU1	20	47733749	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	84188	47733749	15291771	4077	8471										
KCNB1	3745	broad.mit.edu	37	chr20	47990349	47990349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatcaatgcttgacatacttCgcatgtcaatgaccccttct	5	12	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:47990349C>T	ENST00000371741.4	-	2	1914	c.1748G>A	c.(1747-1749)cGa>cAa	p.R583Q		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	583					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGACATACTTCGCATGTCAAT	0.522													33	47					0	0	1	0	0	T	47990349	C	T	47990349	3	4	48	1	0	0	0	0	1	0	0	0	8055	884	31	1	832	1	KCNB1	20	47990349	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	256600	47990349	15035171	4078	8472										
KCNG1	3755	broad.mit.edu	37	chr20	49621311	49621311	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgcacaccgactccacgatGaagacgttgtggcacatctg	10	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:49621311G>T	ENST00000371571.4	-	3	1092	c.807C>A	c.(805-807)ttC>ttA	p.F269L	RP5-955M13.3_ENST00000506387.1_RNA|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	269						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						ACTCCACGATGAAGACGTTGT	0.657													9	14					2.17888e-05	2.39107e-05	1	1	0	T	49621311	G	T	49621311	3	4	48	1	0	0	0	0	1	0	0	0	8070	1281	45	2	738	2	KCNG1	20	49621311	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1630962	49621311	13404209	4079	8473										
NFATC2	4773	broad.mit.edu	37	chr20	50092097	50092097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgacagttttccccgtgattCggtgcacctggtagaaggcg	13	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:50092097C>T	ENST00000371564.3	-	4	1652	c.1433G>A	c.(1432-1434)cGa>cAa	p.R478Q	NFATC2_ENST00000396009.3_Missense_Mutation_p.R478Q|NFATC2_ENST00000414705.1_Missense_Mutation_p.R458Q	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	478	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CCCCGTGATTCGGTGCACCTG	0.522													45	78					0	0	1	0	0	T	50092097	C	T	50092097	3	4	48	1	0	0	0	0	1	0	0	0	10408	884	31	1	1420	1	NFATC2	20	50092097	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	470786	50092097	12933423	4080	8474										
DOK5	55816	broad.mit.edu	37	chr20	53171574	53171574	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcatatttcaggtgttatCataaggtaagactcaattgc	8	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:53171574C>A	ENST00000262593.5	+	2	519	c.169C>A	c.(169-171)Cat>Aat	p.H57N	DOK5_ENST00000395939.1_5'UTR	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	57	PH.						insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			CAGGTGTTATCATAAGGTAAG	0.373													11	14					7.93312e-07	8.98086e-07	1	1	0	A	53171574	C	A	53171574	3	1	48	1	0	0	0	0	1	0	0	0	4727	826	29	2	175	2	DOK5	20	53171574	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3079477	53171574	9853946	4081	8475										
AURKA	6790	broad.mit.edu	37	chr20	54948493	54948493	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagcatgtactgaccacccAaaatctgcaattttaagctc	7	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:54948493A>G	ENST00000395909.4	-	9	1390	c.825T>C	c.(823-825)ttT>ttC	p.F275F	AURKA_ENST00000395915.3_Silent_p.F275F|AURKA_ENST00000395914.1_Silent_p.F275F|AURKA_ENST00000312783.6_Silent_p.F275F|AURKA_ENST00000395913.3_Silent_p.F275F|AURKA_ENST00000395907.1_Silent_p.F275F|AURKA_ENST00000347343.2_Silent_p.F275F|AURKA_ENST00000395911.1_Silent_p.F275F|AURKA_ENST00000371356.2_Silent_p.F275F	NM_198433.1	NP_940835.1	O14965	AURKA_HUMAN	aurora kinase A	275	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|lung(9)|ovary(2)|prostate(1)|skin(2)	22			Colorectal(105;0.202)			CTGACCACCCAAAATCTGCAA	0.423													32	46					0	0	1	0	0	G	54948493	A	G	54948493	2	3	48	1	0	0	0	0	0	0	0	1	1219	127	5	4		4	AURKA	20	54948493	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1776919	54948493	8077027	4082	8476										
CTCFL	140690	broad.mit.edu	37	chr20	56093849	56093850	+	Frame_Shift_Ins	INS	-	-	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcacatggaacatttaaaINSgggtttctcatgagtatgtt							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:56093849_56093850insT	ENST00000426658.2	-	4	1684_1685	c.1023_1024insA	c.(1021-1026)ccttaafs	p.*342fs	CTCFL_ENST00000539382.1_Frame_Shift_Ins_p.*137fs|CTCFL_ENST00000422869.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000429804.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000433949.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000502686.2_Frame_Shift_Ins_p.*80fs|CTCFL_ENST00000422109.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000371196.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000432255.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000243914.3_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000423479.2_Frame_Shift_Ins_p.*342fs|CTCFL_ENST00000481655.1_5'UTR			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	342					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GAACATTTAAAGGGTTTCTCAT	0.47													39	98	---	---	---	---						T	56093850	-	T	56093849	7	5	48	1	0	1	1	0	0	0	0	0	4025	72	3	0	995	0	CTCFL	20	56093849	Frame_Shift_Ins	INS	-	TCGA-ND-A4WC-01A-21D-A28R-08	1145356	56093849	6931671	4083	8477										
PCK1	5105	broad.mit.edu	37	chr20	56137841	56137841	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agctgacggattcaccctacGtggtggccagcatgcggatc	13	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:56137841G>A	ENST00000319441.4	+	4	660	c.496G>A	c.(496-498)Gtg>Atg	p.V166M	PCK1_ENST00000535860.1_Missense_Mutation_p.V34M|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	166					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TTCACCCTACGTGGTGGCCAG	0.617													13	44					0	0	1	0	0	A	56137841	G	A	56137841	3	1	48	1	0	0	0	0	1	0	0	0	11627	1145	40	1	506	1	PCK1	20	56137841	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	43992	56137841	6887679	4084	8478										
RAB22A	57403	broad.mit.edu	37	chr20	56929309	56929309	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgataaacataaatgaactcTttatagaaattagtgagtat	6	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:56929309T>G	ENST00000244040.3	+	6	756	c.475T>G	c.(475-477)Ttt>Gtt	p.F159V		NM_020673.2	NP_065724.1	Q9UL26	RB22A_HUMAN	RAB22A, member RAS oncogene family	159					endocytosis|endosome organization|protein transport|small GTPase mediated signal transduction	early endosome|endosome membrane|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|pancreas(1)	6	all_epithelial(3;5.09e-14)|Lung NSC(12;0.000122)|all_lung(29;0.00042)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;4.73e-08)|all cancers(14;4.83e-07)			AAATGAACTCTTTATAGAAAT	0.393													10	16					0	0	1	0	0	G	56929309	T	G	56929309	3	3	48	1	0	0	0	0	1	0	0	0	12960	1609	56	4	497	4	RAB22A	20	56929309	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	791468	56929309	6096211	4085	8479										
GNAS	2778	broad.mit.edu	37	chr20	57428651	57428651	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgaggctgaacagcccagcTtgggaggcttctggcctaca	13	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:57428651T>G	ENST00000371100.4	+	1	883	c.331T>G	c.(331-333)Ttg>Gtg	p.L111V	GNAS_ENST00000603534.1_Intron|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371102.4_Missense_Mutation_p.L111V|GNAS_ENST00000371099.2_Missense_Mutation_p.L111V|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000306120.3_Silent_p.A47A|GNAS_ENST00000464624.2_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			ACAGCCCAGCTTGGGAGGCTT	0.622			Mis		pituitary adenoma		"McCune-Albright syndrome; pseudohypoparathyroidism, type IA"			TSP Lung(22;0.16)			13	33					0	0	1	0	0	G	57428651	T	G	57428651	3	3	48	1	0	0	0	0	1	0	0	0	6551	1606	56	4	1075	4	GNAS	20	57428651	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	499342	57428651	5596869	4086	8480										
SYCP2	10388	broad.mit.edu	37	chr20	58489048	58489048	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accttcttttgtctccaagcAtgccatttacaaggttgaga	7	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:58489048A>G	ENST00000357552.3	-	12	1037	c.812T>C	c.(811-813)aTg>aCg	p.M271T	SYCP2_ENST00000371001.2_Missense_Mutation_p.M271T			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	271					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GTCTCCAAGCATGCCATTTAC	0.299													3	10					0	0	1	0	0	G	58489048	A	G	58489048	3	3	48	1	0	0	0	0	1	0	0	0	15488	217	8	4	3916	4	SYCP2	20	58489048	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1060397	58489048	4536472	4087	8481										
CDH26	60437	broad.mit.edu	37	chr20	58567518	58567518	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgtggagccaattgaccgaGaatcccctcatgtaaataac	8	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:58567518G>T	ENST00000348616.4	+	10	1669	c.1369G>T	c.(1369-1371)Gaa>Taa	p.E457*	CDH26_ENST00000244047.5_Nonsense_Mutation_p.E457*	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	457	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			AATTGACCGAGAATCCCCTCA	0.403													4	35					0.00024832	0.000265255	1	1	0	T	58567518	G	T	58567518	4	4	48	1	0	0	0	0	0	1	0	0	3132	943	33	2	1407	2	CDH26	20	58567518	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	78470	58567518	4458002	4088	8482										
PSMA7	5688	broad.mit.edu	37	chr20	60713283	60713283	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcatctgtttcaatggcttCgtcagtatagttcttctcca	6	10	6	0	rs12041		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:60713283C>T	ENST00000370873.4	-	5	661	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K	PSMA7_ENST00000370861.1_Missense_Mutation_p.E109K|PSMA7_ENST00000484488.1_5'UTR	NM_002792.3	NP_002783.1	O14818	PSA7_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 7	179					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			large_intestine(1)|lung(2)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			TCAATGGCTTCGTCAGTATAG	0.493													25	29					0	0	1	0	0	T	60713283	C	T	60713283	3	4	48	1	0	0	0	0	1	0	0	0	12720	893	31	1	223	1	PSMA7	20	60713283	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2145765	60713283	2312237	4089	8483										
ADRM1	11047	broad.mit.edu	37	chr20	60883729	60883729	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgtggaagcgtttgccaAagccatgcagaacaacgcca	11	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:60883729A>C	ENST00000253003.2	+	10	1182	c.1136A>C	c.(1135-1137)aAa>aCa	p.K379T	LAMA5_ENST00000492698.1_Intron	NM_007002.2|NM_175573.1	NP_008933.2|NP_783163.1	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1	379	Interaction with UCHL5.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|urinary_tract(1)	5	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			GCGTTTGCCAAAGCCATGCAG	0.552													14	28					0	0	1	0	0	C	60883729	A	C	60883729	3	2	48	1	0	0	0	0	1	0	0	0	344	14	1	4	1170	4	ADRM1	20	60883729	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	170446	60883729	2141791	4090	8484										
NTSR1	4923	broad.mit.edu	37	chr20	61341007	61341007	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctactacttcctgcgcgacGcctgcacctacgccacggcc	9	19	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:61341007G>A	ENST00000370501.3	+	1	819	c.448G>A	c.(448-450)Gcc>Acc	p.A150T		NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	150						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CCTGCGCGACGCCTGCACCTA	0.667													36	75					0	0	1	0	0	A	61341007	G	A	61341007	3	1	48	1	0	0	0	0	1	0	0	0	10757	1087	38	1	450	1	NTSR1	20	61341007	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	457278	61341007	1684513	4091	8485										
NTSR1	4923	broad.mit.edu	37	chr20	61341123	61341123	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgaagccgcaccaagaagttCatcagcgccatctggctcgc	10	15	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:61341123C>A	ENST00000370501.3	+	1	935	c.564C>A	c.(562-564)ttC>ttA	p.F188L		NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	188						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CCAAGAAGTTCATCAGCGCCA	0.677													33	80					1.30897e-18	1.77529e-18	1	1	0	A	61341123	C	A	61341123	3	1	48	1	0	0	0	0	1	0	0	0	10757	825	29	2	566	2	NTSR1	20	61341123	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	116	61341123	1684397	4092	8486										
DIDO1	11083	broad.mit.edu	37	chr20	61527689	61527689	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctccttctcaatatggaGggcaatttttcctacttcgt	6	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:61527689G>T	ENST00000266070.4	-	8	2435	c.2110C>A	c.(2110-2112)Ctc>Atc	p.L704I	DIDO1_ENST00000395335.2_Missense_Mutation_p.L704I|DIDO1_ENST00000395340.1_Missense_Mutation_p.L704I|DIDO1_ENST00000395343.1_Missense_Mutation_p.L704I	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	704	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCAATATGGAGGGCAATTTTT	0.353													20	34					1.56452e-12	1.97515e-12	1	1	0	T	61527689	G	T	61527689	3	4	48	1	0	0	0	0	1	0	0	0	4550	1000	35	5	4677	5	DIDO1	20	61527689	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	186566	61527689	1497831	4093	8487										
C20orf195	79025	broad.mit.edu	37	chr20	62187143	62187143	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggcgtggaagacctacaccGagcgccgcaatgccctgcgt	13	14	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:62187143G>T	ENST00000370098.3	+	2	219	c.127G>T	c.(127-129)Gag>Tag	p.E43*	C20orf195_ENST00000370097.1_Nonsense_Mutation_p.E43*	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	43										large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GACCTACACCGAGCGCCGCAA	0.627													18	37					1.02788e-11	1.28326e-11	1	1	0	T	62187143	G	T	62187143	4	4	48	1	0	0	0	0	0	1	0	0	2114	1059	37	2	129	2	C20orf195	20	62187143	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	659454	62187143	838377	4094	8488										
C20orf195	79025	broad.mit.edu	37	chr20	62187416	62187416	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggacctgttggaacagctcGaccatggccgtgctgagctg	15	11	0	1	rs143315774	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:62187416G>A	ENST00000370098.3	+	2	492	c.400G>A	c.(400-402)Gac>Aac	p.D134N	C20orf195_ENST00000370097.1_Missense_Mutation_p.D134N	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	134										large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GGAACAGCTCGACCATGGCCG	0.667													17	36					0	0	1	0	0	A	62187416	G	A	62187416	3	1	48	1	0	0	0	0	1	0	0	0	2114	1058	37	1	402	1	C20orf195	20	62187416	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	273	62187416	838104	4095	8489										
OPRL1	4987	broad.mit.edu	37	chr20	62729974	62729974	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccctgggctacgtcaacaGctgcctcaaccccatcctct	8	18	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr20:62729974G>A	ENST00000349451.3	+	6	1347	c.935G>A	c.(934-936)aGc>aAc	p.S312N	OPRL1_ENST00000355631.4_Missense_Mutation_p.S312N|OPRL1_ENST00000336866.2_Missense_Mutation_p.S312N	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	312					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TACGTCAACAGCTGCCTCAAC	0.637													35	50					0	0	1	0	0	A	62729974	G	A	62729974	3	1	48	1	0	0	0	0	1	0	0	0	10933	971	34	3	945	3	OPRL1	20	62729974	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	542558	62729974	295546	4096	8490										
TPTE	7179	broad.mit.edu	37	chr21	10906987	10906987	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caaaatctgatggataaattCtccgtgctttttgtttatgt	7	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:10906987C>T	ENST00000298232.7	-	23	1887	c.1520G>A	c.(1519-1521)aGa>aAa	p.R507K	TPTE_ENST00000342420.5_Missense_Mutation_p.R487K|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.R525K	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	525	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGATAAATTCTCCGTGCTTT	0.358													6	54					0	0	1	0	0	T	10906987	C	T	10906987	3	4	48	1	0	0	0	0	1	0	0	0	16490	913	32	3	85	3	TPTE	21	10906987	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		10906987	37222908	4097	8491										
TPTE	7179	broad.mit.edu	37	chr21	10908881	10908881	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaatgagcaattgtcataGtatgtaggaagattctaaaa	8	3	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:10908881G>T	ENST00000298232.7	-	22	1777	c.1410C>A	c.(1408-1410)taC>taA	p.Y470*	TPTE_ENST00000342420.5_Nonsense_Mutation_p.Y450*|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Nonsense_Mutation_p.Y488*	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	488	C2 tensin-type.		L -> P (in dbSNP:rs150482).		signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATTGTCATAGTATGTAGGAA	0.274													8	29					0.00307968	0.00320271	1	1	0	T	10908881	G	T	10908881	4	4	48	1	0	0	0	0	0	1	0	0	16490	1024	36	5	199	5	TPTE	21	10908881	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1894	10908881	37221014	4098	8492										
TPTE	7179	broad.mit.edu	37	chr21	10920137	10920137	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgtgggttttatctgttcGcctttctccaaaataataca	7	9	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:10920137G>A	ENST00000298232.7	-	18	1430	c.1063C>T	c.(1063-1065)Cga>Tga	p.R355*	TPTE_ENST00000342420.5_Nonsense_Mutation_p.R335*|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Nonsense_Mutation_p.R373*	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	373	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTATCTGTTCGCCTTTCTCCA	0.383													11	61					0	0	1	0	0	A	10920137	G	A	10920137	4	1	48	1	0	0	0	0	0	1	0	0	16490	1095	38	1	562	1	TPTE	21	10920137	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11256	10920137	37209758	4099	8493										
TPTE	7179	broad.mit.edu	37	chr21	10942994	10942994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttaacagaataataagtCgtagaagtcgaagtaaatgt	8	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:10942994C>T	ENST00000298232.7	-	11	906	c.539G>A	c.(538-540)cGa>cAa	p.R180Q	TPTE_ENST00000342420.5_Missense_Mutation_p.R160Q|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.R198Q	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	198					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATAATAAGTCGTAGAAGTCG	0.308													6	44					0	0	1	0	0	T	10942994	C	T	10942994	3	4	48	1	0	0	0	0	1	0	0	0	16490	884	31	1	1114	1	TPTE	21	10942994	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	22857	10942994	37186901	4100	8494										
BAGE2	85319	broad.mit.edu	37	chr21	11039094	11039094	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttctttctgttccttttCtccttgtagcctttctataa	3	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:11039094C>A	ENST00000470054.1	-	0	1109									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTTCCTTTTCTCCTTGTAGC	0.408													18	253					2.48551e-13	3.17925e-13	1	1	0	A	11039094	C	A	11039094	1	1	48	0	1	0	0	0	0	0	0	0	1290	928	32	2		2	BAGE2	21	11039094	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	96100	11039094	37090801	4101	8495										
BAGE2	85319	broad.mit.edu	37	chr21	11039109	11039109	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttttctccttgtagcctttCtataaccaactgttcctcag	4	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:11039109C>A	ENST00000470054.1	-	0	1094									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTAGCCTTTCTATAACCAAC	0.398													14	228					0.000151284	0.00016287	1	1	0	A	11039109	C	A	11039109	1	1	48	0	1	0	0	0	0	0	0	0	1290	928	32	2		2	BAGE2	21	11039109	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	15	11039109	37090786	4102	8496										
BAGE2	85319	broad.mit.edu	37	chr21	11058350	11058350	+	RNA	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggtaaaggagagaaatctCtttataaaaccttgaaaagg	11	4	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:11058350C>T	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAGAAATCTCTTTATAAAAC	0.343													7	69					0	0	1	0	0	T	11058350	C	T	11058350	1	4	48	0	1	0	0	0	0	0	0	0	1290	928	32	3		3	BAGE2	21	11058350	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	19241	11058350	37071545	4103	8497										
BAGE2	85319	broad.mit.edu	37	chr21	11097646	11097646	+	RNA	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcagacaatgccagaaaaaCctacaataggatgcagaaag	10	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:11097646C>A	ENST00000470054.1	-	0	223									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gccagaaaaacctacaatagG	0.577													5	68					0.00116845	0.00122532	1	1	0	A	11097646	C	A	11097646	1	1	48	0	1	0	0	0	0	0	0	0	1290	521	18	5		5	BAGE2	21	11097646	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	39296	11097646	37032249	4104	8498										
LIPI	149998	broad.mit.edu	37	chr21	15561492	15561492	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcttcttcattcagcaaaaTccttacgaagttctgaagcc	5	11	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:15561492T>C	ENST00000344577.2	-	2	383	c.358A>G	c.(358-360)Att>Gtt	p.I120V	LIPI_ENST00000536861.1_Missense_Mutation_p.I99V	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	99					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTCAGCAAAATCCTTACGAAG	0.368													12	28					0	0	1	0	0	C	15561492	T	C	15561492	3	2	48	1	0	0	0	0	1	0	0	0	8865	1435	50	4	1123	4	LIPI	21	15561492	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4463846	15561492	32568403	4105	8499										
NRIP1	8204	broad.mit.edu	37	chr21	16337987	16337987	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgattctagaagtgccatttCattatttctgtgactcctgt	7	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:16337987C>A	ENST00000400202.1	-	3	3239	c.2527G>T	c.(2527-2529)Gaa>Taa	p.E843*	NRIP1_ENST00000318948.4_Nonsense_Mutation_p.E843*|NRIP1_ENST00000400199.1_Nonsense_Mutation_p.E843*			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	843	Repression domain 3.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AGTGCCATTTCATTATTTCTG	0.353													27	39					1.38267e-23	1.93402e-23	1	1	0	A	16337987	C	A	16337987	4	1	48	1	0	0	0	0	0	1	0	0	10699	835	29	2	953	2	NRIP1	21	16337987	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	776495	16337987	31791908	4106	8500										
NRIP1	8204	broad.mit.edu	37	chr21	16339938	16339938	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttttgatctttaactttActtttcttcaacaaagtttt	4	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:16339938A>G	ENST00000400202.1	-	3	1288	c.576T>C	c.(574-576)agT>agC	p.S192S	NRIP1_ENST00000318948.4_Silent_p.S192S|NRIP1_ENST00000400199.1_Silent_p.S192S			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	192	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CTTTAACTTTACTTTTCTTCA	0.378													22	38					0	0	1	0	0	G	16339938	A	G	16339938	2	3	48	1	0	0	0	0	0	0	0	1	10699	388	14	4		4	NRIP1	21	16339938	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1951	16339938	31789957	4107	8501										
USP25	29761	broad.mit.edu	37	chr21	17191113	17191113	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctagaagctgcaatgattgAaggagaaattgagtctttac	10	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:17191113A>G	ENST00000285681.2	+	10	1397	c.1028A>G	c.(1027-1029)gAa>gGa	p.E343G	USP25_ENST00000351097.5_Intron|USP25_ENST00000285679.6_Missense_Mutation_p.E343G|USP25_ENST00000400183.2_Missense_Mutation_p.E343G			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	343					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		GCAATGATTGAAGGAGAAATT	0.383													32	55					0	0	1	0	0	G	17191113	A	G	17191113	3	3	48	1	0	0	0	0	1	0	0	0	17115	246	9	4	1066	4	USP25	21	17191113	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	851175	17191113	30938782	4108	8502										
USP25	29761	broad.mit.edu	37	chr21	17214759	17214759	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatctagagcagccatcaaGaagtgatttctcaaagcact	7	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:17214759G>T	ENST00000285681.2	+	18	2606	c.2237G>T	c.(2236-2238)aGa>aTa	p.R746I	USP25_ENST00000351097.5_Intron|USP25_ENST00000285679.6_Missense_Mutation_p.R746I|USP25_ENST00000400183.2_Missense_Mutation_p.R746I			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	746					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		CAGCCATCAAGAAGTGATTTC	0.358													21	53					3.62473e-10	4.42315e-10	1	1	0	T	17214759	G	T	17214759	3	4	48	1	0	0	0	0	1	0	0	0	17115	942	33	2	2307	2	USP25	21	17214759	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23646	17214759	30915136	4109	8503										
USP25	29761	broad.mit.edu	37	chr21	17250772	17250772	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcatgttgtccctcagtcGaactcctgctgatggaagat	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:17250772G>A	ENST00000285681.2	+	25	3611	c.3242G>A	c.(3241-3243)cGa>cAa	p.R1081Q	USP25_ENST00000351097.5_Missense_Mutation_p.R444Q|USP25_ENST00000285679.6_Missense_Mutation_p.R1049Q|USP25_ENST00000400183.2_Missense_Mutation_p.R1119Q			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	1049					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.R1049Q(2)		breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TCCCTCAGTCGAACTCCTGCT	0.438													17	31					0	0	1	0	0	A	17250772	G	A	17250772	3	1	48	1	0	0	0	0	1	0	0	0	17115	1058	37	1	3240	1	USP25	21	17250772	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	36013	17250772	30879123	4110	8504										
CHODL	140578	broad.mit.edu	37	chr21	19628962	19628962	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagtcctcctcagccttgaGaatgaagcagaacagaagtt	11	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:19628962G>T	ENST00000299295.2	+	2	607	c.216G>T	c.(214-216)gaG>gaT	p.E72D	CHODL_ENST00000400131.1_Missense_Mutation_p.E31D|CHODL_ENST00000400135.1_Missense_Mutation_p.E31D|CHODL_ENST00000543733.1_Missense_Mutation_p.E53D|CHODL_ENST00000338326.3_Missense_Mutation_p.E31D|CHODL_ENST00000400127.1_Missense_Mutation_p.E31D|CHODL_ENST00000400128.1_Missense_Mutation_p.E31D	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	72	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		TCAGCCTTGAGAATGAAGCAG	0.502													11	84					0.000673444	0.000709932	1	1	0	T	19628962	G	T	19628962	3	4	48	1	0	0	0	0	1	0	0	0	3386	933	33	2	222	2	CHODL	21	19628962	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2378190	19628962	28500933	4111	8505										
TMPRSS15	5651	broad.mit.edu	37	chr21	19775932	19775932	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagaagatatgcctcttttcGaccccatttttggttttgaa	7	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:19775932G>T	ENST00000284885.3	-	1	41	c.8C>A	c.(7-9)tCg>tAg	p.S3*		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	3					proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						GCCTCTTTTCGACCCCATTTT	0.348													10	48					7.48243e-07	8.49459e-07	1	1	0	T	19775932	G	T	19775932	4	4	48	1	0	0	0	0	0	1	0	0	16305	1059	37	2	3151	2	TMPRSS15	21	19775932	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	146970	19775932	28353963	4112	8506										
NCAM2	4685	broad.mit.edu	37	chr21	22790860	22790860	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cactaatcatataggaacaaGatttcaagaatatattcttg	5	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:22790860G>T	ENST00000400546.1	+	11	1700	c.1451G>T	c.(1450-1452)aGa>aTa	p.R484I	NCAM2_ENST00000284894.7_Missense_Mutation_p.R342I	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	484	Ig-like C2-type 5.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ATAGGAACAAGATTTCAAGAA	0.308													24	42					4.4004e-07	5.01286e-07	1	1	0	T	22790860	G	T	22790860	3	4	48	1	0	0	0	0	1	0	0	0	10249	942	33	2	1493	2	NCAM2	21	22790860	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3014928	22790860	25339035	4113	8507										
MRPL39	54148	broad.mit.edu	37	chr21	26978793	26978793	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtagggagttgaaatgtttTtattcatcacgaagacagta	10	4	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:26978793T>G	ENST00000307301.7	-	2	289	c.248A>C	c.(247-249)aAa>aCa	p.K83T	MRPL39_ENST00000352957.4_Missense_Mutation_p.K83T	NM_080794.3	NP_542984.2	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39	83						mitochondrial ribosome	nucleotide binding			endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	10						TGAAATGTTTTTATTCATCAC	0.433													10	25					0	0	1	0	0	G	26978793	T	G	26978793	3	3	48	1	0	0	0	0	1	0	0	0	9850	1841	64	4	897	4	MRPL39	21	26978793	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4187933	26978793	21151102	4114	8508										
APP	351	broad.mit.edu	37	chr21	27347537	27347537	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagattccactttctcctggAaatgctgccatcataaacac	5	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:27347537A>G	ENST00000358918.3	-	11	1503	c.1304T>C	c.(1303-1305)tTc>tCc	p.F435S	APP_ENST00000448388.2_Missense_Mutation_p.F325S|APP_ENST00000348990.5_Missense_Mutation_p.F360S|APP_ENST00000357903.3_Missense_Mutation_p.F416S|APP_ENST00000440126.3_Missense_Mutation_p.F411S|APP_ENST00000346798.3_Missense_Mutation_p.F435S|APP_ENST00000354192.3_Missense_Mutation_p.F304S|APP_ENST00000359726.3_Missense_Mutation_p.F379S|APP_ENST00000439274.2_Missense_Mutation_p.F379S	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	435					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				TTTCTCCTGGAAATGCTGCCA	0.453													16	41					0	0	1	0	0	G	27347537	A	G	27347537	3	3	48	1	0	0	0	0	1	0	0	0	812	246	9	4	1040	4	APP	21	27347537	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	368744	27347537	20782358	4115	8509										
ADAMTS1	9510	broad.mit.edu	37	chr21	28212196	28212196	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtccgttgctcctcaccaTtattgtctggacagtcctca	8	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:28212196T>A	ENST00000284984.2	-	6	2304	c.1850A>T	c.(1849-1851)aAt>aTt	p.N617I		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	617	Cys-rich.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CTCCTCACCATTATTGTCTGG	0.433													31	72					0	0	1	0	0	A	28212196	T	A	28212196	3	1	48	1	0	0	0	0	1	0	0	0	254	1493	52	4	1069	4	ADAMTS1	21	28212196	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	864659	28212196	19917699	4116	8510										
N6AMT1	29104	broad.mit.edu	37	chr21	30248814	30248814	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattattttcaaaatttcttCtaaaataaaaatcaaaaggt	2	5	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:30248814C>A	ENST00000303775.5	-	6	564		c.e6-1		N6AMT1_ENST00000351429.3_Splice_Site	NM_013240.4	NP_037372.3	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1 (putative)						positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)	12						AAAATTTCTTCTAAAATAAAA	0.323													13	15					0.00136819	0.00143372	1	1	0	A	30248814	C	A	30248814	5	1	48	1	0	0	0	0	0	0	1	0	10161	927	32	2	110	2	N6AMT1	21	30248814	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2036618	30248814	17881081	4117	8511										
RWDD2B	10069	broad.mit.edu	37	chr21	30380935	30380935	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaatcatttttggacatgtGtaagtttctaaggaggtaaa	9	4	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:30380935G>A	ENST00000493196.1	-	2	175	c.75C>T	c.(73-75)taC>taT	p.Y25Y	RWDD2B_ENST00000486719.1_5'UTR	NM_016940.2	NP_058636.1	P57060	RWD2B_HUMAN	RWD domain containing 2B	25										endometrium(1)|kidney(1)|large_intestine(8)|lung(2)	12						TTGGACATGTGTAAGTTTCTA	0.403													11	16					0	0	1	0	0	A	30380935	G	A	30380935	2	1	48	1	0	0	0	0	0	0	0	1	13807	1372	48	3		3	RWDD2B	21	30380935	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	132121	30380935	17748960	4118	8512										
USP16	0	broad.mit.edu	37	chr21	30403021	30403021	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agactgtaagactgacaataAagtgaaagataaagctgaag	10	4	0	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:30403021A>C	ENST00000334352.4	+	4	398	c.167A>C	c.(166-168)aAa>aCa	p.K56T	USP16_ENST00000399975.3_Missense_Mutation_p.K56T|USP16_ENST00000399976.2_Missense_Mutation_p.K56T|USP16_ENST00000535828.1_Intron	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	56					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						ACTGACAATAAAGTGAAAGAT	0.368													10	38					0	0	1	0	0	C	30403021	A	C	30403021	3	2	48	1	0	0	0	0	1	0	0	0	17106	14	1	4	173	4	USP16	21	30403021	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	22086	30403021	17726874	4119	8513										
KRTAP19-3	337970	broad.mit.edu	37	chr21	31864143	31864143	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaaagccagagccatatcCgtagcctccatagccacagc	7	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:31864143C>A	ENST00000334063.4	-	1	132	c.133G>T	c.(133-135)Gga>Tga	p.G45*		NM_181609.3	NP_853640.1	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	45						intermediate filament				large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	9						GAGCCATATCCGTAGCCTCCA	0.567													143	245					1.13124e-70	1.64409e-70	1	1	0	A	31864143	C	A	31864143	4	1	48	1	0	0	0	0	0	1	0	0	8572	661	23	5	116	5	KRTAP19-3	21	31864143	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1461122	31864143	16265752	4120	8514										
KRTAP6-2	337967	broad.mit.edu	37	chr21	31971111	31971111	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatagccacagcgcaggcttCcatagccatagcctaggcct	9	14	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:31971111C>T	ENST00000334897.3	-	1	108	c.83G>A	c.(82-84)gGa>gAa	p.G28E		NM_181604.1	NP_853635.1	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	28						intermediate filament				endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11						GCGCAGGCTTCCATAGCCATA	0.572													36	64					0	0	1	0	0	T	31971111	C	T	31971111	3	4	48	1	0	0	0	0	1	0	0	0	8608	855	30	3	108	3	KRTAP6-2	21	31971111	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	106968	31971111	16158784	4121	8515										
KRTAP21-2	337978	broad.mit.edu	37	chr21	32119291	32119291	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtagcaagaggaatagcatCttctgtagcaaagtggtcgg	13	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:32119291C>A	ENST00000333892.2	-	1	260	c.230G>T	c.(229-231)aGa>aTa	p.R77I		NM_181617.1	NP_853648.1	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	77						intermediate filament				lung(4)|skin(2)|upper_aerodigestive_tract(1)	7						GGAATAGCATCTTCTGTAGCA	0.483													73	115					1.15074e-40	1.66211e-40	1	1	0	A	32119291	C	A	32119291	3	1	48	1	0	0	0	0	1	0	0	0	8581	913	32	2	23	2	KRTAP21-2	21	32119291	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	148180	32119291	16010604	4122	8516										
TIAM1	7074	broad.mit.edu	37	chr21	32638913	32638913	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctctcctcagtgtctggcaTgctctgcacagaggctgctg	12	13	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:32638913T>G	ENST00000286827.3	-	5	847	c.376A>C	c.(376-378)Atg>Ctg	p.M126L	TIAM1_ENST00000541036.1_Missense_Mutation_p.M126L|TIAM1_ENST00000469412.1_Intron	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	126					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GTGTCTGGCATGCTCTGCACA	0.552													44	60					0	0	1	0	0	G	32638913	T	G	32638913	3	3	48	1	0	0	0	0	1	0	0	0	15949	1464	51	4	4499	4	TIAM1	21	32638913	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	519622	32638913	15490982	4123	8517										
HUNK	30811	broad.mit.edu	37	chr21	33346944	33346944	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacaagaacagcgacgtgaTcaacactgtgctctccaacc	7	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:33346944T>C	ENST00000270112.2	+	7	1448	c.1088T>C	c.(1087-1089)aTc>aCc	p.I363T	HUNK_ENST00000465574.1_3'UTR	NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	363					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						AGCGACGTGATCAACACTGTG	0.542													16	92					0	0	1	0	0	C	33346944	T	C	33346944	3	2	48	1	0	0	0	0	1	0	0	0	7501	1435	50	4	1114	4	HUNK	21	33346944	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	708031	33346944	14782951	4124	8518										
TCP10L	140290	broad.mit.edu	37	chr21	33949164	33949164	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcttgacgtctcctggaaaGatttttatctctattttcct	6	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:33949164G>T	ENST00000300258.3	-	5	681	c.568C>A	c.(568-570)Ctt>Att	p.L190I	TCP10L_ENST00000491828.1_5'UTR	NM_144659.5	NP_653260.1			t-complex 10-like											breast(1)|central_nervous_system(1)|liver(1)|skin(1)	4						CTCCTGGAAAGATTTTTATCT	0.448													31	52					2.70662e-09	3.24368e-09	1	1	0	T	33949164	G	T	33949164	3	4	48	1	0	0	0	0	1	0	0	0	15770	942	33	2	83	2	TCP10L	21	33949164	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	602220	33949164	14180731	4125	8519										
SYNJ1	8867	broad.mit.edu	37	chr21	34003475	34003475	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttattccagtcatcattcaAtgtcaggttggagccagaaa	8	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:34003475A>C	ENST00000382491.3	-	28	4535	c.4411T>G	c.(4411-4413)Ttg>Gtg	p.L1471V	SYNJ1_ENST00000357345.3_3'UTR|SYNJ1_ENST00000433931.2_Missense_Mutation_p.L1557V|SYNJ1_ENST00000382499.2_3'UTR|SYNJ1_ENST00000322229.7_Missense_Mutation_p.L1518V	NM_001160306.1	NP_001153778.1	O43426	SYNJ1_HUMAN	synaptojanin 1	1518	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						TCATCATTCAATGTCAGGTTG	0.493													16	72					0	0	1	0	0	C	34003475	A	C	34003475	3	2	48	1	0	0	0	0	1	0	0	0	15508	98	4	4	173	4	SYNJ1	21	34003475	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	54311	34003475	14126420	4126	8520										
SYNJ1	8867	broad.mit.edu	37	chr21	34045776	34045776	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaggttccgacacatactcGaattttcttaggctttgaat	7	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:34045776G>A	ENST00000382499.2	-	14	1716	c.1717C>T	c.(1717-1719)Cga>Tga	p.R573*	SYNJ1_ENST00000357345.3_Nonsense_Mutation_p.R534*|SYNJ1_ENST00000433931.2_Nonsense_Mutation_p.R573*|SYNJ1_ENST00000382491.3_Nonsense_Mutation_p.R529*|SYNJ1_ENST00000322229.7_Nonsense_Mutation_p.R534*	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	534	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding	p.R534*(2)		breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						ACACATACTCGAATTTTCTTA	0.388													14	26					0	0	1	0	0	A	34045776	G	A	34045776	4	1	48	1	0	0	0	0	0	1	0	0	15508	1066	37	1	3222	1	SYNJ1	21	34045776	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	42301	34045776	14084119	4127	8521										
GART	2618	broad.mit.edu	37	chr21	34889392	34889392	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggctttgacatgtcctgaacGtaggacaggtaacagtgaat	12	7	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:34889392G>A	ENST00000381831.3	-	16	2274	c.2011C>T	c.(2011-2013)Cgt>Tgt	p.R671C	GART_ENST00000543717.1_Missense_Mutation_p.R223C|GART_ENST00000381815.4_Missense_Mutation_p.R671C|GART_ENST00000381839.3_Missense_Mutation_p.R671C	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	671	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	TGTCCTGAACGTAGGACAGGT	0.448													5	93					0	0	1	0	0	A	34889392	G	A	34889392	3	1	48	1	0	0	0	0	1	0	0	0	6282	1145	40	1	1049	1	GART	21	34889392	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	843616	34889392	13240503	4128	8522										
SON	6651	broad.mit.edu	37	chr21	34921873	34921873	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaagtcaaagaagcataaAaagcacaaaaacaaaaagaa	5	5	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:34921873A>C	ENST00000356577.4	+	3	811	c.336A>C	c.(334-336)aaA>aaC	p.K112N	SON_ENST00000290239.6_Missense_Mutation_p.K112N|SON_ENST00000381679.4_Missense_Mutation_p.K112N|SON_ENST00000381692.2_Intron|SON_ENST00000300278.4_Missense_Mutation_p.K112N	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	112					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						AGAAGCATAAAAAGCACaaaa	0.328											OREG0003562	type=REGULATORY REGION|Gene=AK091233|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	18					0	0	1	0	0	C	34921873	A	C	34921873	3	2	48	1	0	0	0	0	1	0	0	0	14979	11	1	4	346	4	SON	21	34921873	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	32481	34921873	13208022	4129	8523										
SON	6651	broad.mit.edu	37	chr21	34927011	34927011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agactcttcattaagatctcGaagtaagcgttccaaatctt	6	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:34927011G>A	ENST00000356577.4	+	3	5949	c.5474G>A	c.(5473-5475)cGa>cAa	p.R1825Q	SON_ENST00000290239.6_Missense_Mutation_p.R1825Q|SON_ENST00000381679.4_Missense_Mutation_p.R1825Q|SON_ENST00000381692.2_Intron|SON_ENST00000300278.4_Missense_Mutation_p.R1825Q	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1825					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TTAAGATCTCGAAGTAAGCGT	0.393													28	54					0	0	1	0	0	A	34927011	G	A	34927011	3	1	48	1	0	0	0	0	1	0	0	0	14979	1058	37	1	5484	1	SON	21	34927011	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5138	34927011	13202884	4130	8524										
SON	6651	broad.mit.edu	37	chr21	34948145	34948145	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaggtggcaaccacctgaAtttctattggtccatgatag	10	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:34948145A>G	ENST00000356577.4	+	11	7642	c.7167A>G	c.(7165-7167)gaA>gaG	p.E2389E	SON_ENST00000470533.1_3'UTR|SON_ENST00000290239.6_3'UTR|DONSON_ENST00000303113.6_Intron|SON_ENST00000381692.2_Silent_p.E417E|AP000304.2_ENST00000439593.1_RNA	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	2389	DRBM.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						AACCACCTGAATTTCTATTGG	0.358													18	18					0	0	1	0	0	G	34948145	A	G	34948145	2	3	48	1	0	0	0	0	0	0	0	1	14979	98	4	4		4	SON	21	34948145	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	21134	34948145	13181750	4131	8525										
RUNX1	861	broad.mit.edu	37	chr21	36259341	36259341	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcaacgcctcgctcatcttGcctgggctcagcgcggtgga	14	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:36259341G>C	ENST00000344691.4	-	1	1646	c.69C>G	c.(67-69)ggC>ggG	p.G23G	RUNX1_ENST00000399240.1_Silent_p.G23G|RUNX1_ENST00000358356.5_Silent_p.G23G|RUNX1_ENST00000437180.1_Silent_p.G50G|RUNX1_ENST00000325074.5_Silent_p.G38G|RUNX1_ENST00000486278.2_Silent_p.G26G|RUNX1_ENST00000300305.3_Silent_p.G50G	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	23					myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.F40fs*14(1)|p.R38fs*16(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						CGCTCATCTTGCCTGGGCTCA	0.692			T	"RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"	"AML, preB- ALL, T-ALL"								13	25					0	0	1	0	0	C	36259341	G	C	36259341	2	2	48	1	0	0	0	0	0	0	0	1	13797	1306	46	5		5	RUNX1	21	36259341	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1311196	36259341	11870554	4132	8526										
SETD4	54093	broad.mit.edu	37	chr21	37431146	37431146	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaacttccgcagagttttCgtcttctgatccggcttgtt	9	11	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:37431146C>T	ENST00000399215.1	-	1	1413	c.41G>A	c.(40-42)cGa>cAa	p.R14Q	SETD4_ENST00000399207.1_Missense_Mutation_p.R14Q|SETD4_ENST00000481477.1_5'UTR|SETD4_ENST00000332131.4_Missense_Mutation_p.R14Q|SETD4_ENST00000399212.1_5'UTR|SETD4_ENST00000399208.2_Missense_Mutation_p.R14Q|SETD4_ENST00000399201.1_5'UTR|SETD4_ENST00000399205.1_5'UTR			Q9NVD3	SETD4_HUMAN	SET domain containing 4	14										autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						GCAGAGTTTTCGTCTTCTGAT	0.348													31	74					0	0	1	0	0	T	37431146	C	T	37431146	3	4	48	1	0	0	0	0	1	0	0	0	14186	884	31	1	1344	1	SETD4	21	37431146	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1171805	37431146	10698749	4133	8527										
DOPEY2	9980	broad.mit.edu	37	chr21	37626108	37626108	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatcccagctaacccttgtCgacttggtgtgtgcactcag	10	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:37626108C>T	ENST00000399151.3	+	23	5245	c.5160C>T	c.(5158-5160)gtC>gtT	p.V1720V		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1720					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TAACCCTTGTCGACTTGGTGT	0.493													40	78					0	0	1	0	0	T	37626108	C	T	37626108	2	4	48	1	0	0	0	0	0	0	0	1	4735	871	31	1		1	DOPEY2	21	37626108	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	194962	37626108	10503787	4134	8528										
TTC3	7267	broad.mit.edu	37	chr21	38538603	38538603	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctgaatatcagctaccaAgatcagtaccagtggtgccg	9	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:38538603A>C	ENST00000399017.2	+	33	6834	c.4087A>C	c.(4087-4089)Aga>Cga	p.R1363R	TTC3_ENST00000354749.2_Silent_p.R1363R|TTC3_ENST00000355666.1_Silent_p.R1363R|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1363					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TCAGCTACCAAGATCAGTACC	0.468													41	71					0	0	1	0	0	C	38538603	A	C	38538603	2	2	48	1	0	0	0	0	0	0	0	1	16758	64	3	4		4	TTC3	21	38538603	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	912495	38538603	9591292	4135	8529										
ERG	2078	broad.mit.edu	37	chr21	39775498	39775498	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggtgagcctctggaagtcGtccttggtcatcttgcacag	14	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:39775498G>A	ENST00000442448.1	-	6	814	c.543C>T	c.(541-543)gaC>gaT	p.D181D	ERG_ENST00000417133.2_Silent_p.D181D|ERG_ENST00000398897.1_Silent_p.D82D|ERG_ENST00000398919.2_Silent_p.D181D|ERG_ENST00000453032.2_Silent_p.D82D|ERG_ENST00000288319.7_Silent_p.D174D|ERG_ENST00000398905.1_Silent_p.D174D|ERG_ENST00000429727.2_Intron|ERG_ENST00000398907.1_Silent_p.D174D|ERG_ENST00000398910.1_Silent_p.D181D|ERG_ENST00000398911.1_Silent_p.D181D	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	181	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TCTGGAAGTCGTCCTTGGTCA	0.522			T	"EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"	"Ewing sarcoma, prostate, AML"								31	52					0	0	1	0	0	A	39775498	G	A	39775498	2	1	48	1	0	0	0	0	0	0	0	1	5250	1136	40	1		1	ERG	21	39775498	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1236895	39775498	8354397	4136	8530										
BRWD1	54014	broad.mit.edu	37	chr21	40636553	40636553	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgctcatctaagacataaTtattagaatctctaataagt	4	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:40636553T>G	ENST00000342449.3	-	17	1796	c.1718A>C	c.(1717-1719)aAt>aCt	p.N573T	BRWD1_ENST00000380800.3_Missense_Mutation_p.N573T|BRWD1_ENST00000333229.2_Missense_Mutation_p.N573T	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	573					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TAAGACATAATTATTAGAATC	0.383													5	23					0	0	1	0	0	G	40636553	T	G	40636553	3	3	48	1	0	0	0	0	1	0	0	0	1527	1493	52	4	5587	4	BRWD1	21	40636553	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	861055	40636553	7493342	4137	8531										
IGSF5	150084	broad.mit.edu	37	chr21	41151135	41151135	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcaccatgcttctgacgccGacgtgtactcttacaatacg	9	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:41151135G>A	ENST00000380588.4	+	5	940	c.837G>A	c.(835-837)ccG>ccA	p.P279P	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	279						integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				TTCTGACGCCGACGTGTACTC	0.483													26	41					0	0	1	0	0	A	41151135	G	A	41151135	2	1	48	1	0	0	0	0	0	0	0	1	7645	1045	37	1		1	IGSF5	21	41151135	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	514582	41151135	6978760	4138	8532										
IGSF5	150084	broad.mit.edu	37	chr21	41151230	41151230	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttctgctgtagaagaaaaaGaggtaatttttttgttcatt	8	3	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:41151230G>T	ENST00000380588.4	+	5	1035	c.932G>T	c.(931-933)aGa>aTa	p.R311I	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	311						integral to membrane|tight junction		p.R311I(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				AGAAGAAAAAGAGGTAATTTT	0.413													9	26					2.62144e-13	3.35237e-13	1	1	0	T	41151230	G	T	41151230	3	4	48	1	0	0	0	0	1	0	0	0	7645	942	33	2	950	2	IGSF5	21	41151230	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	95	41151230	6978665	4139	8533										
DSCAM	1826	broad.mit.edu	37	chr21	41447035	41447035	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagcacaaacagcagcaagAcccccaccaggatacaggag	11	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:41447035A>G	ENST00000400454.1	-	27	5294	c.4817T>C	c.(4816-4818)gTc>gCc	p.V1606A		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1606					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAGCAGCAAGACCCCCACCAG	0.582													23	28					0	0	1	0	0	G	41447035	A	G	41447035	3	3	48	1	0	0	0	0	1	0	0	0	4794	275	10	4	1249	4	DSCAM	21	41447035	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	295805	41447035	6682860	4140	8534										
DSCAM	1826	broad.mit.edu	37	chr21	41559882	41559882	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaatagcatggcaggaaaaGaaaccagaatcttctctcac	7	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:41559882G>T	ENST00000400454.1	-	13	3063	c.2586C>A	c.(2584-2586)ttC>ttA	p.F862L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	862	Ig-like C2-type 9.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGCAGGAAAAGAAACCAGAAT	0.403													16	26					2.23348e-06	2.50077e-06	1	1	0	T	41559882	G	T	41559882	3	4	48	1	0	0	0	0	1	0	0	0	4794	933	33	2	3536	2	DSCAM	21	41559882	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	112847	41559882	6570013	4141	8535										
DSCAM	1826	broad.mit.edu	37	chr21	41710160	41710160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccattgttctcaaatgccaCttggcggtggttgaaaggaa	11	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:41710160C>T	ENST00000400454.1	-	8	2128	c.1651G>A	c.(1651-1653)Gtg>Atg	p.V551M		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	551	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCAAATGCCACTTGGCGGTGG	0.458													26	68					0	0	1	0	0	T	41710160	C	T	41710160	3	4	48	1	0	0	0	0	1	0	0	0	4794	565	20	3	4491	3	DSCAM	21	41710160	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	150278	41710160	6419735	4142	8536										
FAM3B	54097	broad.mit.edu	37	chr21	42720602	42720602	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attcaggtctagctgggtatTtattgcagcaaaaggcttgg	12	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:42720602T>G	ENST00000398652.3	+	8	752	c.686T>G	c.(685-687)tTt>tGt	p.F229C	FAM3B_ENST00000398646.3_Missense_Mutation_p.F213C|FAM3B_ENST00000357985.2_Missense_Mutation_p.F190C|FAM3B_ENST00000479810.2_3'UTR|FAM3B_ENST00000398647.3_Missense_Mutation_p.F142C			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	190					apoptosis|insulin secretion	extracellular space	cytokine activity			central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				AGCTGGGTATTTATTGCAGCA	0.418													19	36					0	0	1	0	0	G	42720602	T	G	42720602	3	3	48	1	0	0	0	0	1	0	0	0	5592	1841	64	4	595	4	FAM3B	21	42720602	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1010442	42720602	5409293	4143	8537										
UMODL1	89766	broad.mit.edu	37	chr21	43531635	43531635	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctacagggaaactccatcaTggagccaccctcctggcctt	9	15	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:43531635T>C	ENST00000400427.1	+	11	2483	c.2087T>C	c.(2086-2088)aTg>aCg	p.M696T	UMODL1_ENST00000408989.2_Missense_Mutation_p.M768T|UMODL1_ENST00000400424.1_Missense_Mutation_p.M568T|UMODL1_ENST00000408910.2_Missense_Mutation_p.M640T	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	693						cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						AACTCCATCATGGAGCCACCC	0.637													5	77					0	0	1	0	0	C	43531635	T	C	43531635	3	2	48	1	0	0	0	0	1	0	0	0	17039	1464	51	4	2345	4	UMODL1	21	43531635	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	811033	43531635	4598260	4144	8538										
UBASH3A	53347	broad.mit.edu	37	chr21	43846924	43846924	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcttagcagcttacaggccTtgcaggtaatagaacattcc	9	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:43846924T>C	ENST00000319294.6	+	8	1196	c.1165T>C	c.(1165-1167)Ttg>Ctg	p.L389L	UBASH3A_ENST00000398367.1_Silent_p.L351L|UBASH3A_ENST00000291535.6_Silent_p.L351L	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	389						cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						CTTACAGGCCTTGCAGGTAAT	0.448													14	65					0	0	1	0	0	C	43846924	T	C	43846924	2	2	48	1	0	0	0	0	0	0	0	1	16899	1606	56	4		4	UBASH3A	21	43846924	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	315289	43846924	4282971	4145	8539										
UBASH3A	53347	broad.mit.edu	37	chr21	43862683	43862683	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagagctgaaagaggcaaaTttcaacattgacactgatta	9	6	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:43862683T>G	ENST00000319294.6	+	12	1639	c.1608T>G	c.(1606-1608)aaT>aaG	p.N536K	UBASH3A_ENST00000398367.1_Missense_Mutation_p.N498K|UBASH3A_ENST00000291535.6_Missense_Mutation_p.N498K	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	536	Phosphatase-like.					cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						AAGAGGCAAATTTCAACATTG	0.413													32	52					0	0	1	0	0	G	43862683	T	G	43862683	3	3	48	1	0	0	0	0	1	0	0	0	16899	1490	52	4	1654	4	UBASH3A	21	43862683	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	15759	43862683	4267212	4146	8540										
PDE9A	5152	broad.mit.edu	37	chr21	44152236	44152236	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcagagcagttctcaaggTacagagtcttctaaacttac	8	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:44152236T>C	ENST00000291539.6	+	6	557		c.e6+2		PDE9A_ENST00000398225.3_Splice_Site|PDE9A_ENST00000398224.3_Splice_Site|PDE9A_ENST00000398234.3_Splice_Site|PDE9A_ENST00000328862.6_Splice_Site|PDE9A_ENST00000349112.3_Intron|PDE9A_ENST00000398232.3_Splice_Site|PDE9A_ENST00000539837.1_Intron|PDE9A_ENST00000398227.3_Intron|PDE9A_ENST00000335440.6_Intron|PDE9A_ENST00000380328.2_Intron|PDE9A_ENST00000470987.1_Splice_Site|PDE9A_ENST00000335512.4_Splice_Site|PDE9A_ENST00000398236.3_Splice_Site|PDE9A_ENST00000398229.3_Intron	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A						platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						GTTCTCAAGGTACAGAGTCTT	0.527													8	19					0	0	1	0	0	C	44152236	T	C	44152236	5	2	48	1	0	0	0	0	0	0	1	0	11701	1652	57	4	601	4	PDE9A	21	44152236	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	289553	44152236	3977659	4147	8541										
RRP1B	23076	broad.mit.edu	37	chr21	45107839	45107839	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaaaggaagcggaaacttggAgttgtgcccgtcaatggcag	14	7	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:45107839A>G	ENST00000340648.4	+	13	1701	c.1584A>G	c.(1582-1584)ggA>ggG	p.G528G		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	528					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		GGAAACTTGGAGTTGTGCCCG	0.632													42	49					0	0	1	0	0	G	45107839	A	G	45107839	2	3	48	1	0	0	0	0	0	0	0	1	13739	291	11	4		4	RRP1B	21	45107839	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	955603	45107839	3022056	4148	8542										
ICOSLG	23308	broad.mit.edu	37	chr21	45658337	45658337	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccctgaacttaccagctcGaaggctgctgaagagcagga	11	13	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:45658337G>A	ENST00000407780.3	-	2	176	c.49C>T	c.(49-51)Cga>Tga	p.R17*	ICOSLG_ENST00000400379.3_Nonsense_Mutation_p.R17*|ICOSLG_ENST00000400377.3_Nonsense_Mutation_p.R17*|ICOSLG_ENST00000344330.4_Nonsense_Mutation_p.R17*			O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand	17					B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding	p.R17*(1)		endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TTACCAGCTCGAAGGCTGCTG	0.607													5	34					0	0	1	0	0	A	45658337	G	A	45658337	4	1	48	1	0	0	0	0	0	1	0	0	7530	1066	37	1	883	1	ICOSLG	21	45658337	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	550498	45658337	2471558	4149	8543										
TRPM2	7226	broad.mit.edu	37	chr21	45819213	45819213	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgctaccggaaggacgaagaGagagcccagaaactgctcac	12	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:45819213G>T	ENST00000397928.1	+	14	2542	c.2097G>T	c.(2095-2097)gaG>gaT	p.E699D	TRPM2_ENST00000397932.2_Missense_Mutation_p.E699D|TRPM2_ENST00000300482.5_Missense_Mutation_p.E699D|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.E679D	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	699						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						AGGACGAAGAGAGAGCCCAGA	0.627													28	75					8.58068e-18	1.15595e-17	1	1	0	T	45819213	G	T	45819213	3	4	48	1	0	0	0	0	1	0	0	0	16646	933	33	2	2151	2	TRPM2	21	45819213	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	160876	45819213	2310682	4150	8544										
COL6A2	0	broad.mit.edu	37	chr21	47536586	47536586	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaatttggagccgacggtCgcaaggtaggctggctgggt	18	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:47536586C>T	ENST00000300527.4	+	9	1053	c.949C>T	c.(949-951)Cgc>Tgc	p.R317C	COL6A2_ENST00000409416.1_Missense_Mutation_p.R317C|COL6A2_ENST00000310645.5_Missense_Mutation_p.R317C|COL6A2_ENST00000357838.4_Missense_Mutation_p.R317C|COL6A2_ENST00000397763.1_Missense_Mutation_p.R317C	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	317	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGCCGACGGTCGCAAGGTAGG	0.622													15	31					0	0	1	0	0	T	47536586	C	T	47536586	3	4	48	1	0	0	0	0	1	0	0	0	3723	884	31	1	979	1	COL6A2	21	47536586	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1717373	47536586	593309	4151	8545										
MCM3AP	8888	broad.mit.edu	37	chr21	47674319	47674319	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctgacctgccacaactctCtggggactgctcctctacat	7	16	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:47674319C>T	ENST00000397708.1	-	20	4377	c.4123G>A	c.(4123-4125)Gag>Aag	p.E1375K	MCM3AP_ENST00000467026.1_5'UTR|MCM3AP_ENST00000291688.1_Missense_Mutation_p.E1375K|MCM3AP-AS1_ENST00000590829.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1375					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					CCACAACTCTCTGGGGACTGC	0.612													22	50					0	0	1	0	0	T	47674319	C	T	47674319	3	4	48	1	0	0	0	0	1	0	0	0	9437	922	32	3	1859	3	MCM3AP	21	47674319	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	137733	47674319	455576	4152	8546										
MCM3AP	8888	broad.mit.edu	37	chr21	47705107	47705107	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagagaaggttgaccaaatcGaaatggcggcttagatggaa	13	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:47705107G>A	ENST00000397708.1	-	2	348	c.94C>T	c.(94-96)Cga>Tga	p.R32*	MCM3AP_ENST00000291688.1_Nonsense_Mutation_p.R32*			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	32					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TGACCAAATCGAAATGGCGGC	0.463													20	47					0	0	1	0	0	A	47705107	G	A	47705107	4	1	48	1	0	0	0	0	0	1	0	0	9437	1066	37	1	5960	1	MCM3AP	21	47705107	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30788	47705107	424788	4153	8547										
PCNT	5116	broad.mit.edu	37	chr21	47773050	47773050	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aactcctggcgcgcacctctCgtgtggaagatttagaacag	11	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr21:47773050C>T	ENST00000359568.5	+	10	1596	c.1489C>T	c.(1489-1491)Cgt>Tgt	p.R497C	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	497	Glu-rich.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GCGCACCTCTCGTGTGGAAGA	0.488													19	39					0	0	1	0	0	T	47773050	C	T	47773050	3	4	48	1	0	0	0	0	1	0	0	0	11636	884	31	1	1527	1	PCNT	21	47773050	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	67943	47773050	356845	4154	8548										
SLC25A18	83733	broad.mit.edu	37	chr22	18064149	18064149	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgcctgatgaagacggctCgggcggagggcttcttcggc	16	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:18064149C>T	ENST00000327451.5	+	5	707	c.169C>T	c.(169-171)Cgg>Tgg	p.R57W	AC004019.13_ENST00000443935.1_RNA|SLC25A18_ENST00000497401.1_3'UTR|SLC25A18_ENST00000399813.1_Missense_Mutation_p.R57W	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	57						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GAAGACGGCTCGGGCGGAGGG	0.652													45	98					0	0	1	0	0	T	18064149	C	T	18064149	3	4	48	1	0	0	0	0	1	0	0	0	14534	875	31	1	179	1	SLC25A18	22	18064149	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		18064149	33240417	4155	8549										
CLTCL1	8218	broad.mit.edu	37	chr22	19203720	19203720	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaaggctttgacagtgaccGaaatctcttcaggatcccgt	9	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:19203720G>A	ENST00000263200.10	-	19	3038	c.2966C>T	c.(2965-2967)tCg>tTg	p.S989L	CLTCL1_ENST00000353891.5_Missense_Mutation_p.S989L|CLTCL1_ENST00000427926.1_Missense_Mutation_p.S989L	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	989	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					GACAGTGACCGAAATCTCTTC	0.423			T	?	ALCL								25	28					0	0	1	0	0	A	19203720	G	A	19203720	3	1	48	1	0	0	0	0	1	0	0	0	3590	1059	37	1	2012	1	CLTCL1	22	19203720	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1139571	19203720	32100846	4156	8550										
CLTCL1	8218	broad.mit.edu	37	chr22	19241726	19241726	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttactcttcatctcaataTtaaagatctgaagtgtcttc	4	8	5	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:19241726T>G	ENST00000263200.10	-	3	347	c.275A>C	c.(274-276)aAt>aCt	p.N92T	CLTCL1_ENST00000353891.5_Missense_Mutation_p.N92T|CLTCL1_ENST00000427926.1_Missense_Mutation_p.N92T	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	92	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					CATCTCAATATTAAAGATCTG	0.343			T	?	ALCL								14	18					0	0	1	0	0	G	19241726	T	G	19241726	3	3	48	1	0	0	0	0	1	0	0	0	3590	1493	52	4	4767	4	CLTCL1	22	19241726	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	38006	19241726	32062840	4157	8551										
MRPL40	64976	broad.mit.edu	37	chr22	19423164	19423164	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccttagcttctttgcagagaGcggcctcaggtggagctcac	12	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:19423164G>A	ENST00000333130.3	+	4	953	c.300G>A	c.(298-300)gaG>gaA	p.E100E	HIRA_ENST00000541063.1_Intron|HIRA_ENST00000546308.1_Intron|MRPL40_ENST00000471259.1_3'UTR	NM_003776.2	NP_003767.2	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40	100					anatomical structure morphogenesis	mitochondrial ribosome|nucleus				endometrium(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					TTTGCAGAGAGCGGCCTCAGG	0.507													40	290					0	0	1	0	0	A	19423164	G	A	19423164	2	1	48	1	0	0	0	0	0	0	0	1	9852	962	34	3		3	MRPL40	22	19423164	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	181438	19423164	31881402	4158	8552										
TBX1	6899	broad.mit.edu	37	chr22	19751728	19751728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcggggaaggccgaccctgCcacgccaggccgcgtgcact	16	16	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:19751728C>T	ENST00000332710.4	+	5	692	c.563C>T	c.(562-564)gCc>gTc	p.A188V	TBX1_ENST00000359500.3_Missense_Mutation_p.A188V|TBX1_ENST00000329705.7_Missense_Mutation_p.A188V	NM_080647.1	NP_542378.1	O43435	TBX1_HUMAN	T-box 1	188					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|lung(3)|ovary(2)	8	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				GCCGACCCTGCCACGCCAGGC	0.662													25	54					0	0	1	0	0	T	19751728	C	T	19751728	3	4	48	1	0	0	0	0	1	0	0	0	15709	739	26	3	577	3	TBX1	22	19751728	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	328564	19751728	31552838	4159	8553										
DGCR8	54487	broad.mit.edu	37	chr22	20074084	20074084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagtggagtatgcagtgctcGatgagttagaagattttact	13	4	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:20074084G>A	ENST00000351989.3	+	2	1027	c.598G>A	c.(598-600)Gat>Aat	p.D200N	DGCR8_ENST00000407755.1_Missense_Mutation_p.D200N|DGCR8_ENST00000383024.2_Missense_Mutation_p.D200N	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	200	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					TGCAGTGCTCGATGAGTTAGA	0.483													46	102					0	0	1	0	0	A	20074084	G	A	20074084	3	1	48	1	0	0	0	0	1	0	0	0	4492	1058	37	1	600	1	DGCR8	22	20074084	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	322356	20074084	31230482	4160	8554										
PI4KA	5297	broad.mit.edu	37	chr22	21072993	21072993	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcacttacttgatgatagccGacacgttggtgatcttgtta	10	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:21072993G>A	ENST00000255882.6	-	44	5320	c.5234C>T	c.(5233-5235)tCg>tTg	p.S1745L	PI4KA_ENST00000414196.3_Missense_Mutation_p.S497L|PI4KA_ENST00000572273.1_Missense_Mutation_p.S1687L	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1687	Pleckstrin homology (PH) domain conferring phosphoinositide binding specificity (By similarity).				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GATGATAGCCGACACGTTGGT	0.483													41	70					0	0	1	0	0	A	21072993	G	A	21072993	3	1	48	1	0	0	0	0	1	0	0	0	11920	1059	37	1	1122	1	PI4KA	22	21072993	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	998909	21072993	30231573	4161	8555										
AIFM3	150209	broad.mit.edu	37	chr22	21331227	21331227	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcggggccaggagggaaaGgtgggcccttctcccttctc	15	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:21331227G>A	ENST00000399167.2	+	13	1458	c.1218_splice	c.e13+1	p.K406_splice	AIFM3_ENST00000333607.6_Splice_Site_p.K406_splice|AIFM3_ENST00000399163.2_Splice_Site_p.K406_splice|AIFM3_ENST00000335375.5_Splice_Site_p.K394_splice|AIFM3_ENST00000465606.1_3'UTR|AIFM3_ENST00000405089.1_Splice_Site_p.K412_splice|AIFM3_ENST00000440238.2_Splice_Site_p.K406_splice	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AGGAGGGAAAGGTGGGCCCTT	0.607													24	57					0	0	1	0	0	A	21331227	G	A	21331227	5	1	48	1	0	0	0	0	0	0	1	0	425	1014	35	3	1282	3	AIFM3	22	21331227	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	258234	21331227	29973339	4162	8556										
LZTR1	8216	broad.mit.edu	37	chr22	21344752	21344752	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggacaagatgtttgtattCtctgggcaaagcggagccaa	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:21344752C>A	ENST00000215739.8	+	8	1088	c.729C>A	c.(727-729)ttC>ttA	p.F243L	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Missense_Mutation_p.F224L	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	243					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGTTTGTATTCTCTGGGCAAA	0.567													34	67					1.56442e-22	2.17472e-22	1	1	0	A	21344752	C	A	21344752	3	1	48	1	0	0	0	0	1	0	0	0	9182	912	32	2	759	2	LZTR1	22	21344752	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	13525	21344752	29959814	4163	8557										
SLC7A4	6545	broad.mit.edu	37	chr22	21385316	21385316	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcacagaccgccgtgggttCtgggcctcctcactggaggc	15	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:21385316C>A	ENST00000382932.2	-	2	853	c.786G>T	c.(784-786)caG>caT	p.Q262H	SLC7A4_ENST00000403586.1_Missense_Mutation_p.Q262H	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	262					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GCCGTGGGTTCTGGGCCTCCT	0.622													20	34					8.10497e-08	9.43176e-08	1	1	0	A	21385316	C	A	21385316	3	1	48	1	0	0	0	0	1	0	0	0	14753	912	32	2	1137	2	SLC7A4	22	21385316	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	40564	21385316	29919250	4164	8558										
PPIL2	23759	broad.mit.edu	37	chr22	22024873	22024873	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatctcccacaaacaaattTtcgtcgtttaccttttgacc	4	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:22024873T>G	ENST00000406385.1	+	3	161	c.101T>G	c.(100-102)tTt>tGt	p.F34C	PPIL2_ENST00000335025.7_Missense_Mutation_p.F34C|PPIL2_ENST00000456792.2_Missense_Mutation_p.F34C|PPIL2_ENST00000412327.1_Missense_Mutation_p.F34C|PPIL2_ENST00000398831.3_Missense_Mutation_p.F34C|PPIL2_ENST00000492445.2_Missense_Mutation_p.F34C			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	34					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					CAAACAAATTTTCGTCGTTTA	0.368													20	35					0	0	1	0	0	G	22024873	T	G	22024873	3	3	48	1	0	0	0	0	1	0	0	0	12375	1841	64	4	111	4	PPIL2	22	22024873	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	639557	22024873	29279693	4165	8559										
ZNF280A	129025	broad.mit.edu	37	chr22	22869151	22869151	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacacgatgggattttctttCttgggatcaaaggtcttgtt	10	6	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:22869151C>A	ENST00000302097.3	-	2	1056	c.804G>T	c.(802-804)aaG>aaT	p.K268N		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	268					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GATTTTCTTTCTTGGGATCAA	0.428													26	51					3.73808e-20	5.11168e-20	1	1	0	A	22869151	C	A	22869151	3	1	48	1	0	0	0	0	1	0	0	0	17871	912	32	2	828	2	ZNF280A	22	22869151	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	844278	22869151	28435415	4166	8560										
ZNF280A	129025	broad.mit.edu	37	chr22	22869289	22869289	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccaaggaaatgttactccAttctgaacatggtttgatga	10	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:22869289A>G	ENST00000302097.3	-	2	918	c.666T>C	c.(664-666)aaT>aaC	p.N222N		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ATGTTACTCCATTCTGAACAT	0.438													30	60					0	0	1	0	0	G	22869289	A	G	22869289	2	3	48	1	0	0	0	0	0	0	0	1	17871	214	8	4		4	ZNF280A	22	22869289	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	138	22869289	28435277	4167	8561										
DDTL	100037417	broad.mit.edu	37	chr22	24313580	24313580	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgaatgaggaagctctcttCatttatttcatatgaggatg	9	5	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:24313580C>A	ENST00000215770.5	+	3	404	c.390C>A	c.(388-390)ttC>ttA	p.F130L	DDT_ENST00000398344.4_3'UTR|DDT_ENST00000404092.1_3'UTR|DDT_ENST00000350608.3_3'UTR	NM_001084393.1	NP_001077862.1	A6NHG4	DDTL_HUMAN	D-dopachrome tautomerase-like	130						cytoplasm	lyase activity			kidney(1)|urinary_tract(1)	2						AAGCTCTCTTCATTTATTTCA	0.473													24	42					0.00278032	0.00290051	1	1	0	A	24313580	C	A	24313580	3	1	48	1	0	0	0	0	1	0	0	0	4363	825	29	2	400	2	DDTL	22	24313580	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1444291	24313580	26990986	4168	8562										
GSTT2	2953	broad.mit.edu	37	chr22	24323182	24323182	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgcagatcaacagcctgggGaaactgccgacgctcaagga	12	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:24323182G>A	ENST00000215780.5	+	2	206	c.156G>A	c.(154-156)ggG>ggA	p.G52G	GSTT2_ENST00000402588.3_Silent_p.G52G	NM_000854.3	NP_000845.1	P0CG30	GSTT2_HUMAN	glutathione S-transferase theta 2	52	GST N-terminal.					cytoplasm	glutathione transferase activity			lung(1)	1						ACAGCCTGGGGAAACTGCCGA	0.542													27	90					0	0	1	0	0	A	24323182	G	A	24323182	2	1	48	1	0	0	0	0	0	0	0	1	6886	1161	41	3		3	GSTT2	22	24323182	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9602	24323182	26981384	4169	8563										
SUSD2	56241	broad.mit.edu	37	chr22	24579121	24579121	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcacctgctgcttggattTccgggacttctgcctggaga	13	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:24579121T>G	ENST00000358321.3	+	2	434	c.173T>G	c.(172-174)tTc>tGc	p.F58C		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	58	SMB.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						TGCTTGGATTTCCGGGACTTC	0.617													21	112					0	0	1	0	0	G	24579121	T	G	24579121	3	3	48	1	0	0	0	0	1	0	0	0	15463	1783	62	4	179	4	SUSD2	22	24579121	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	255939	24579121	26725445	4170	8564										
UPB1	51733	broad.mit.edu	37	chr22	24911222	24911222	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccgtgttccagacgcagttCggaaggatcgcggtgaacat	13	11	0	2	rs143438140	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:24911222C>T	ENST00000413389.2	+	6	2064	c.471C>T	c.(469-471)ttC>ttT	p.F157F	UPB1_ENST00000326010.5_Silent_p.F225F			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	225	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding	p.F225F(1)		endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					AGACGCAGTTCGGAAGGATCG	0.537													47	83					0	0	1	0	0	T	24911222	C	T	24911222	2	4	48	1	0	0	0	0	0	0	0	1	17061	883	31	1		1	UPB1	22	24911222	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	332101	24911222	26393344	4171	8565										
UPB1	51733	broad.mit.edu	37	chr22	24911325	24911325	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttcaacccctcggccacgAtaggagcactcaggtcactc	8	16	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:24911325A>G	ENST00000413389.2	+	6	2167	c.574A>G	c.(574-576)Ata>Gta	p.I192V	UPB1_ENST00000326010.5_Missense_Mutation_p.I260V			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	260	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					CTCGGCCACGATAGGAGCACT	0.612													34	64					0	0	1	0	0	G	24911325	A	G	24911325	3	3	48	1	0	0	0	0	1	0	0	0	17061	333	12	4	800	4	UPB1	22	24911325	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	103	24911325	26393241	4172	8566										
PIWIL3	440822	broad.mit.edu	37	chr22	25150111	25150111	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcagtttgtggctcacatCggcacagagggtaatgctgt	14	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:25150111C>T	ENST00000332271.5	-	8	1263	c.847G>A	c.(847-849)Gat>Aat	p.D283N	PIWIL3_ENST00000533313.1_Missense_Mutation_p.D174N|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.D174N	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	283					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TGGCTCACATCGGCACAGAGG	0.408													17	32					0	0	1	0	0	T	25150111	C	T	25150111	3	4	48	1	0	0	0	0	1	0	0	0	12006	884	31	1	1857	1	PIWIL3	22	25150111	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	238786	25150111	26154455	4173	8567										
PIWIL3	440822	broad.mit.edu	37	chr22	25152504	25152504	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ataaagagtttccatcaaatAtatggcgctctccaaatttc	5	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:25152504A>G	ENST00000332271.5	-	5	940	c.524T>C	c.(523-525)aTa>aCa	p.I175T	PIWIL3_ENST00000533313.1_Missense_Mutation_p.I66T|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.I66T	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	175					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCCATCAAATATATGGCGCTC	0.343													9	18					0	0	1	0	0	G	25152504	A	G	25152504	3	3	48	1	0	0	0	0	1	0	0	0	12006	449	16	4	2192	4	PIWIL3	22	25152504	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2393	25152504	26152062	4174	8568										
ADRBK2	157	broad.mit.edu	37	chr22	26000402	26000402	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaaataacctttgacaagAttttcaatcagaaaattggt	6	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:26000402A>C	ENST00000324198.5	+	2	364	c.172A>C	c.(172-174)Att>Ctt	p.I58L		NM_005160.3	NP_005151.2	P35626	ARBK2_HUMAN	adrenergic, beta, receptor kinase 2	58	N-terminal.|RGS.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|skin(3)|stomach(2)	32					Adenosine triphosphate(DB00171)	CTTTGACAAGATTTTCAATCA	0.378													22	43					0	0	1	0	0	C	26000402	A	C	26000402	3	2	48	1	0	0	0	0	1	0	0	0	343	333	12	4	178	4	ADRBK2	22	26000402	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	847898	26000402	25304164	4175	8569										
MYO18B	84700	broad.mit.edu	37	chr22	26343735	26343735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggacctcctgaagcgcatcGatgaggaccaggatgacctg	13	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:26343735G>A	ENST00000335473.7	+	36	5939	c.5689G>A	c.(5689-5691)Gat>Aat	p.D1897N	MYO18B_ENST00000536101.1_Missense_Mutation_p.D1897N|MYO18B_ENST00000407587.2_Missense_Mutation_p.D1898N	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1897	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAAGCGCATCGATGAGGACCA	0.552													22	30					0	0	1	0	0	A	26343735	G	A	26343735	3	1	48	1	0	0	0	0	1	0	0	0	10113	1058	37	1	5827	1	MYO18B	22	26343735	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	343333	26343735	24960831	4176	8570										
MYO18B	84700	broad.mit.edu	37	chr22	26400763	26400763	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtactctgtccctggccacaGatactatgaggactccttct	8	13	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:26400763G>T	ENST00000335473.7	+	42	6662	c.6412G>T	c.(6412-6414)Gat>Tat	p.D2138Y	MYO18B_ENST00000536101.1_Missense_Mutation_p.D2138Y|MYO18B_ENST00000407587.2_Missense_Mutation_p.D2139Y	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2138						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCTGGCCACAGATACTATGAG	0.552													9	101					1.76689e-08	2.08373e-08	1	1	0	T	26400763	G	T	26400763	3	4	48	1	0	0	0	0	1	0	0	0	10113	942	33	2	6574	2	MYO18B	22	26400763	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	57028	26400763	24903803	4177	8571										
HPS4	89781	broad.mit.edu	37	chr22	26868837	26868837	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtccattgtaaaaattaaaGaatccaactagctgatccag	7	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:26868837G>T	ENST00000398145.2	-	5	961	c.345C>A	c.(343-345)ttC>ttA	p.F115L	HPS4_ENST00000398141.1_Missense_Mutation_p.F110L|HPS4_ENST00000402105.3_Missense_Mutation_p.F110L|HPS4_ENST00000336873.5_Missense_Mutation_p.F115L	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	115					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						AAAAATTAAAGAATCCAACTA	0.463									Hermansky-Pudlak syndrome				43	78					1.23103e-26	1.74228e-26	1	1	0	T	26868837	G	T	26868837	3	4	48	1	0	0	0	0	1	0	0	0	7381	933	33	2	1821	2	HPS4	22	26868837	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	468074	26868837	24435729	4178	8572										
CHEK2	11200	broad.mit.edu	37	chr22	29091232	29091232	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtggatacccactaaggcTtaatattggtagagagagaa	12	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:29091232T>G	ENST00000544772.1	-	13	2033		c.e13-2		CHEK2_ENST00000382566.1_Splice_Site|CHEK2_ENST00000402731.1_Splice_Site|CHEK2_ENST00000404276.1_Splice_Site|CHEK2_ENST00000348295.3_Splice_Site|CHEK2_ENST00000403642.1_Splice_Site|CHEK2_ENST00000328354.6_Splice_Site|CHEK2_ENST00000382580.2_Splice_Site|CHEK2_ENST00000405598.1_Splice_Site|CHEK2_ENST00000382578.1_Splice_Site|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2						cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCACTAAGGCTTAATATTGGT	0.388			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					7	10					0	0	1	0	0	G	29091232	T	G	29091232	5	3	48	1	0	0	0	0	0	0	1	0	3357	1623	56	4	389	4	CHEK2	22	29091232	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2222395	29091232	22213334	4179	8573										
C22orf31	25770	broad.mit.edu	37	chr22	29454749	29454749	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctattttttgctctttaacTtgggccatttcttgagtaca	6	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:29454749T>G	ENST00000216071.4	-	3	905	c.854A>C	c.(853-855)aAg>aCg	p.K285T		NM_015370.1	NP_056185.1	O95567	CV031_HUMAN	chromosome 22 open reading frame 31	285										cervix(1)|endometrium(1)|kidney(17)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	27						GCTCTTTAACTTGGGCCATTT	0.483													6	88					0	0	1	0	0	G	29454749	T	G	29454749	3	3	48	1	0	0	0	0	1	0	0	0	2157	1609	56	4	22	4	C22orf31	22	29454749	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	363517	29454749	21849817	4180	8574										
THOC5	8563	broad.mit.edu	37	chr22	29915099	29915099	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctcagcgagtggtcagcaAtcactgtttgctgtgagtga	13	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:29915099A>C	ENST00000490103.1	-	15	1507	c.1385T>G	c.(1384-1386)aTt>aGt	p.I462S	CTA-256D12.11_ENST00000411969.1_RNA|THOC5_ENST00000397873.2_Missense_Mutation_p.I462S|THOC5_ENST00000397871.1_Missense_Mutation_p.I462S|THOC5_ENST00000397872.1_Missense_Mutation_p.I462S	NM_003678.4	NP_003669.4	Q13769	THOC5_HUMAN	THO complex 5	462					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTGGTCAGCAATCACTGTTTG	0.582													30	58					0	0	1	0	0	C	29915099	A	C	29915099	3	2	48	1	0	0	0	0	1	0	0	0	15927	101	4	4	690	4	THOC5	22	29915099	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	460350	29915099	21389467	4181	8575										
DRG1	4733	broad.mit.edu	37	chr22	31829935	31829935	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacgttggaggatgaggatgTcattcaaattgtgaagaagt	13	3	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:31829935T>C	ENST00000331457.4	+	9	1243	c.1082T>C	c.(1081-1083)gTc>gCc	p.V361A		NM_004147.3	NP_004138.1	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	361					multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	11						GATGAGGATGTCATTCAAATT	0.478													14	29					0	0	1	0	0	C	31829935	T	C	31829935	3	2	48	1	0	0	0	0	1	0	0	0	4787	1667	58	4	1116	4	DRG1	22	31829935	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1914836	31829935	19474631	4182	8576										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31859097	31859097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctacgctcaccaaagacaCgcttactatctccaaactct	3	15	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:31859097C>T	ENST00000397525.1	-	6	831	c.608G>A	c.(607-609)cGt>cAt	p.R203H	RP11-247I13.11_ENST00000483736.1_RNA|EIF4ENIF1_ENST00000397523.1_Missense_Mutation_p.R203H|RP11-247I13.11_ENST00000464523.1_RNA|RP11-247I13.8_ENST00000439588.1_RNA|EIF4ENIF1_ENST00000344710.5_Intron|EIF4ENIF1_ENST00000330125.5_Missense_Mutation_p.R203H	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	203	Arg-rich.					nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ACCAAAGACACGCTTACTATC	0.403													3	24					0	0	1	0	0	T	31859097	C	T	31859097	3	4	48	1	0	0	0	0	1	0	0	0	5063	536	19	1	2408	1	EIF4ENIF1	22	31859097	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29162	31859097	19445469	4183	8577										
DEPDC5	9681	broad.mit.edu	37	chr22	32289731	32289731	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaccgcagcagtactcttCgagatggtgagaaccttcat	11	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:32289731C>T	ENST00000400246.1	+	39	4339	c.4197C>T	c.(4195-4197)ttC>ttT	p.F1399F	DEPDC5_ENST00000535622.1_Silent_p.F1299F|DEPDC5_ENST00000400248.1_Silent_p.F1368F|DEPDC5_ENST00000266091.3_Silent_p.F1377F|DEPDC5_ENST00000400249.2_Silent_p.F1368F|DEPDC5_ENST00000382112.3_Silent_p.F1390F|DEPDC5_ENST00000539165.1_Silent_p.F216F|DEPDC5_ENST00000382105.2_3'UTR|DEPDC5_ENST00000382111.2_Silent_p.F1399F			O75140	DEPD5_HUMAN	DEP domain containing 5	1368				L -> P (in Ref. 6; CAH18159).	intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CAGTACTCTTCGAGATGGTGA	0.483													26	31					0	0	1	0	0	T	32289731	C	T	32289731	2	4	48	1	0	0	0	0	0	0	0	1	4470	883	31	1		1	DEPDC5	22	32289731	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	430634	32289731	19014835	4184	8578										
SLC5A4	6527	broad.mit.edu	37	chr22	32651209	32651209	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaacagccatcaccaccagAaaatagatgacaatgactga	6	12	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:32651209A>C	ENST00000266086.4	-	1	119	c.108T>G	c.(106-108)ttT>ttG	p.F36L	RP1-90G24.10_ENST00000434942.1_RNA	NM_014227.2	NP_055042.1	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (glucose activated ion channel), member 4	36					carbohydrate transport|sodium ion transport	integral to membrane	symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|pancreas(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TCACCACCAGAAAATAGATGA	0.542													76	120					0	0	1	0	0	C	32651209	A	C	32651209	3	2	48	1	0	0	0	0	1	0	0	0	14721	243	9	4	1931	4	SLC5A4	22	32651209	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	361478	32651209	18653357	4185	8579										
RFPL3	10738	broad.mit.edu	37	chr22	32754065	32754065	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatacctctatgcatgaaaAggttgtcacttgtcacaact	6	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:32754065A>C	ENST00000249007.4	+	1	212	c.7A>C	c.(7-9)Agg>Cgg	p.R3R	RFPL3_ENST00000397468.1_Intron	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	3							zinc ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						ATGCATGAAAAGGTTGTCACT	0.483													29	64					0	0	1	0	0	C	32754065	A	C	32754065	2	2	48	1	0	0	0	0	0	0	0	1	13306	63	3	4		4	RFPL3	22	32754065	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	102856	32754065	18550501	4186	8580										
FBXO7	25793	broad.mit.edu	37	chr22	32894360	32894360	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattcctggtcctggggagaCgcccagccagtttcctccac	10	16	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:32894360C>T	ENST00000266087.7	+	9	1739	c.1412C>T	c.(1411-1413)aCg>aTg	p.T471M	FBXO7_ENST00000397426.1_Missense_Mutation_p.T357M|FBXO7_ENST00000382058.3_Missense_Mutation_p.T392M	NM_012179.3	NP_036311.3	Q9Y3I1	FBX7_HUMAN	F-box protein 7	471					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTGGGGAGACGCCCAGCCAG	0.562													34	75					0	0	1	0	0	T	32894360	C	T	32894360	3	4	48	1	0	0	0	0	1	0	0	0	5792	536	19	1	1487	1	FBXO7	22	32894360	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140295	32894360	18410206	4187	8581										
HMGXB4	10042	broad.mit.edu	37	chr22	35661203	35661203	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggtctgacgcctcccagttCgcagagtcccacagtgctaa	11	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:35661203C>T	ENST00000216106.5	+	5	950	c.822C>T	c.(820-822)ttC>ttT	p.F274F	HMGXB4_ENST00000444518.2_Silent_p.F165F	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	274					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding	p.F274F(1)		breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTCCCAGTTCGCAGAGTCCC	0.522													23	47					0	0	1	0	0	T	35661203	C	T	35661203	2	4	48	1	0	0	0	0	0	0	0	1	7279	883	31	1		1	HMGXB4	22	35661203	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2766843	35661203	15643363	4188	8582										
MCM5	4174	broad.mit.edu	37	chr22	35815913	35815913	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtcagcagaggctgcagaGaaactgaagaaccgctacat	11	10	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:35815913G>T	ENST00000216122.4	+	14	1894	c.1740G>T	c.(1738-1740)gaG>gaT	p.E580D	MCM5_ENST00000382011.5_Missense_Mutation_p.E537D	NM_006739.3	NP_006730.2	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	580					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29						AGGCTGCAGAGAAACTGAAGA	0.632													23	60					3.5997e-14	4.67138e-14	1	1	0	T	35815913	G	T	35815913	3	4	48	1	0	0	0	0	1	0	0	0	9439	933	33	2	1790	2	MCM5	22	35815913	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	154710	35815913	15488653	4189	8583										
APOL5	80831	broad.mit.edu	37	chr22	36122895	36122895	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcttcatggctatggtcaaGaattttgtggccaagagaca	12	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:36122895G>T	ENST00000249044.2	+	3	780	c.780G>T	c.(778-780)aaG>aaT	p.K260N		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	260					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						CTATGGTCAAGAATTTTGTGG	0.498													10	166					0.000442599	0.00046913	1	1	0	T	36122895	G	T	36122895	3	4	48	1	0	0	0	0	1	0	0	0	806	933	33	2	790	2	APOL5	22	36122895	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	306982	36122895	15181671	4190	8584										
MYH9	4627	broad.mit.edu	37	chr22	36685180	36685180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taaggtcctccatctccgtgCggaactgcttgttgagccgc	11	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:36685180C>T	ENST00000216181.5	-	32	4738	c.4508G>A	c.(4507-4509)cGc>cAc	p.R1503H		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1503					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CATCTCCGTGCGGAACTGCTT	0.637			T	ALK	ALCL		"Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"		Hereditary Macrothrombocytopenia, MYH9-associated				18	41					0	0	1	0	0	T	36685180	C	T	36685180	3	4	48	1	0	0	0	0	1	0	0	0	10089	768	27	1	1414	1	MYH9	22	36685180	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	562285	36685180	14619386	4191	8585										
SH3BP1	23616	broad.mit.edu	37	chr22	38039669	38039669	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggctcagtcaggcaaccaaGaattcaggcagcagtcaagg	12	10	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:38039669G>T	ENST00000599616.1	+	5	300	c.300G>T	c.(298-300)aaG>aaT	p.K100N	SH3BP1_ENST00000336738.5_Missense_Mutation_p.K164N|SH3BP1_ENST00000357436.4_Missense_Mutation_p.K164N|Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000495174.1_3'UTR|SH3BP1_ENST00000442465.2_Missense_Mutation_p.K164N			Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	164	BAR.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					AGGCAACCAAGAATTCAGGCA	0.587											OREG0026546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	51					3.86212e-05	4.21111e-05	1	1	0	T	38039669	G	T	38039669	3	4	48	1	0	0	0	0	1	0	0	0	14297	933	33	2	518	2	SH3BP1	22	38039669	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1354489	38039669	13264897	4192	8586										
MICALL1	85377	broad.mit.edu	37	chr22	38329085	38329085	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcagcgccaggctgatgtCgagtatgagctccggtgcct	15	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:38329085C>T	ENST00000215957.6	+	13	2400	c.2274C>T	c.(2272-2274)gtC>gtT	p.V758V	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	758						cytoplasm|cytoskeleton	protein binding|zinc ion binding	p.V758V(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					AGGCTGATGTCGAGTATGAGC	0.632													37	58					0	0	1	0	0	T	38329085	C	T	38329085	2	4	48	1	0	0	0	0	0	0	0	1	9620	871	31	1		1	MICALL1	22	38329085	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	289416	38329085	12975481	4193	8587										
CBX6	23466	broad.mit.edu	37	chr22	39262755	39262755	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggcggaggcttgtacagcGcaaaggcgccgaacttcatg	15	11	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:39262755G>A	ENST00000407418.3	-	5	821	c.698C>T	c.(697-699)gCg>gTg	p.A233V	CBX6_ENST00000216083.6_Missense_Mutation_p.A215V			O95503	CBX6_HUMAN	chromobox homolog 6	233					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex				large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(58;0.04)					CTTGTACAGCGCAAAGGCGCC	0.682													29	58					0	0	1	0	0	A	39262755	G	A	39262755	3	1	48	1	0	0	0	0	1	0	0	0	2740	1087	38	1	544	1	CBX6	22	39262755	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	933670	39262755	12041811	4194	8588										
APOBEC3F	200316	broad.mit.edu	37	chr22	39441500	39441500	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatgccttggtacaaattCgatgacaattatgcattcct	6	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:39441500C>T	ENST00000308521.5	+	4	876	c.519C>T	c.(517-519)ttC>ttT	p.F173F	APOBEC3G_ENST00000452957.2_Intron	NM_145298.5	NP_660341.2	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	178					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|skin(2)	16	Melanoma(58;0.04)					GGTACAAATTCGATGACAATT	0.507													85	164					0	0	1	0	0	T	39441500	C	T	39441500	2	4	48	1	0	0	0	0	0	0	0	1	790	883	31	1		1	APOBEC3F	22	39441500	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	178745	39441500	11863066	4195	8589										
CACNA1I	8911	broad.mit.edu	37	chr22	40015325	40015325	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctctgcaggatggtcgagTactccctggaccttcagaac	10	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:40015325T>C	ENST00000336649.4	+	6	493	c.493T>C	c.(493-495)Tac>Cac	p.Y165H	CACNA1I_ENST00000401624.1_Missense_Mutation_p.Y165H|CACNA1I_ENST00000400164.3_Missense_Mutation_p.Y165H|CACNA1I_ENST00000402142.3_Missense_Mutation_p.Y165H|CACNA1I_ENST00000404898.1_Missense_Mutation_p.Y165H|CACNA1I_ENST00000407673.1_Missense_Mutation_p.Y165H			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	165					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GATGGTCGAGTACTCCCTGGA	0.642													7	114					0	0	1	0	0	C	40015325	T	C	40015325	3	2	48	1	0	0	0	0	1	0	0	0	2564	1638	57	4	507	4	CACNA1I	22	40015325	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	573825	40015325	11289241	4196	8590										
ST13	6767	broad.mit.edu	37	chr22	41222622	41222622	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctctggtattttgacatatTtgctgggttctgagccacat	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:41222622T>C	ENST00000216218.3	-	12	1511	c.1030A>G	c.(1030-1032)Aat>Gat	p.N344D		NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	344	STI1.						protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						TTTGACATATTTGCTGGGTTC	0.393													40	61					0	0	1	0	0	C	41222622	T	C	41222622	3	2	48	1	0	0	0	0	1	0	0	0	15265	1841	64	4	83	4	ST13	22	41222622	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1207297	41222622	10081944	4197	8591										
XPNPEP3	63929	broad.mit.edu	37	chr22	41318387	41318387	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccgttctagagatccaaaGagattgtttggccctctgct	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:41318387G>T	ENST00000357137.4	+	8	1190	c.1106G>T	c.(1105-1107)aGa>aTa	p.R369I	XPNPEP3_ENST00000544094.1_Missense_Mutation_p.R346I	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	369					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						GAGATCCAAAGAGATTGTTTG	0.473													5	195					0.000602214	0.000636035	1	1	0	T	41318387	G	T	41318387	3	4	48	1	0	0	0	0	1	0	0	0	17503	942	33	2	1136	2	XPNPEP3	22	41318387	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	95765	41318387	9986179	4198	8592										
MEI1	150365	broad.mit.edu	37	chr22	42141899	42141899	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatttcttaggttggctataGaattccagagtgagccttca	10	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:42141899G>T	ENST00000401548.3	+	14	1589	c.1549G>T	c.(1549-1551)Gaa>Taa	p.E517*	MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540833.1_Nonsense_Mutation_p.E257*|MEI1_ENST00000400107.1_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	517							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GTTGGCTATAGAATTCCAGAG	0.502													10	43					0.000442599	0.00046913	1	1	0	T	42141899	G	T	42141899	4	4	48	1	0	0	0	0	0	1	0	0	9514	943	33	2	1603	2	MEI1	22	42141899	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	823512	42141899	9162667	4199	8593										
SREBF2	6721	broad.mit.edu	37	chr22	42273340	42273340	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctcctttaaccccctgacTtccctgctgcagtggggagg	10	15	1	1	rs142090611	by1000genomes	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:42273340T>G	ENST00000361204.4	+	8	1660	c.1494T>G	c.(1492-1494)acT>acG	p.T498T		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	498					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ACCCCCTGACTTCCCTGCTGC	0.617													8	91					0	0	1	0	0	G	42273340	T	G	42273340	2	3	48	1	0	0	0	0	0	0	0	1	15197	1596	56	4		4	SREBF2	22	42273340	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	131441	42273340	9031226	4200	8594										
SEPT3	55964	broad.mit.edu	37	chr22	42377819	42377819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaccatgaagaccggtttcGacttcaacatcatggtcgtt	9	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:42377819G>A	ENST00000396425.3	+	2	312	c.181G>A	c.(181-183)Gac>Aac	p.D61N	SEPT3_ENST00000396426.3_Missense_Mutation_p.D61N|SEPT3_ENST00000291236.11_Intron|SEPT3_ENST00000328414.8_Missense_Mutation_p.D61N|SEPT3_ENST00000406029.1_Intron|CTA-250D10.19_ENST00000424613.1_RNA	NM_019106.5	NP_061979.3	Q9UH03	SEPT3_HUMAN	septin 3	61					cell cycle|cytokinesis	cell junction|septin complex	GTP binding			breast(1)|kidney(3)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17						GACCGGTTTCGACTTCAACAT	0.567													16	20					0	0	1	0	0	A	42377819	G	A	42377819	3	1	48	1	0	0	0	0	1	0	0	0	14118	1058	37	1	187	1	SEPT3	22	42377819	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	104479	42377819	8926747	4201	8595										
WBP2NL	164684	broad.mit.edu	37	chr22	42415733	42415733	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgatgccatttgatctgaTgacgaacctcactgttgaac	8	9	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:42415733T>C	ENST00000328823.9	+	3	270	c.239T>C	c.(238-240)aTg>aCg	p.M80T	WBP2NL_ENST00000543212.1_Missense_Mutation_p.M6T	NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	80	GRAM.				egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						TTTGATCTGATGACGAACCTC	0.408													7	119					0	0	1	0	0	C	42415733	T	C	42415733	3	2	48	1	0	0	0	0	1	0	0	0	17319	1464	51	4	249	4	WBP2NL	22	42415733	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	37914	42415733	8888833	4202	8596										
SCUBE1	80274	broad.mit.edu	37	chr22	43608571	43608571	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcagggcttgaagccatcgGccgagaagaagcctggagaa	16	9	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:43608571G>A	ENST00000360835.3	-	17	2207	c.2081C>T	c.(2080-2082)gCc>gTc	p.A694V		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	694					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GAAGCCATCGGCCGAGAAGAA	0.677													4	12					0	0	1	0	0	A	43608571	G	A	43608571	3	1	48	1	0	0	0	0	1	0	0	0	13997	1203	42	3	909	3	SCUBE1	22	43608571	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1192838	43608571	7695995	4203	8597										
PPARA	5465	broad.mit.edu	37	chr22	46627934	46627934	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttatgaggccatattcgcCatgctgtcttctgtgatgaa	10	8	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:46627934C>T	ENST00000396000.2	+	7	1222	c.957C>T	c.(955-957)gcC>gcT	p.A319A	PPARA_ENST00000407236.1_Silent_p.A319A|PPARA_ENST00000434345.2_3'UTR|PPARA_ENST00000402126.1_Silent_p.A319A|PPARA_ENST00000262735.5_Silent_p.A319A			Q07869	PPARA_HUMAN	peroxisome proliferator-activated receptor alpha	319	Ligand-binding.|Required for heterodimerization with RXRA.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	15		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	CCATATTCGCCATGCTGTCTT	0.463													33	36					0	0	1	0	0	T	46627934	C	T	46627934	2	4	48	1	0	0	0	0	0	0	0	1	12341	581	21	3		3	PPARA	22	46627934	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3019363	46627934	4676632	4204	8598										
TBC1D22A	25771	broad.mit.edu	37	chr22	47287219	47287219	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctccagagaaaacaaaaaGaatattttgcatttattgag	6	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:47287219G>T	ENST00000337137.4	+	6	932	c.766G>T	c.(766-768)Gaa>Taa	p.E256*	TBC1D22A_ENST00000380995.1_Nonsense_Mutation_p.E209*|TBC1D22A_ENST00000406733.1_Nonsense_Mutation_p.E209*|TBC1D22A_ENST00000355704.3_Nonsense_Mutation_p.E178*|TBC1D22A_ENST00000407381.3_Nonsense_Mutation_p.E197*	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	256	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		AAAACAAAAAGAATATTTTGC	0.398													14	26					4.7546e-09	5.67505e-09	1	1	0	T	47287219	G	T	47287219	4	4	48	1	0	0	0	0	0	1	0	0	15667	943	33	2	788	2	TBC1D22A	22	47287219	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	659285	47287219	4017347	4205	8599										
BRD1	23774	broad.mit.edu	37	chr22	50191483	50191483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagaaaggccgccgcggtgCcgcagcaggccgctcaggca	17	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:50191483C>T	ENST00000216267.8	-	5	2554	c.2068G>A	c.(2068-2070)Gca>Aca	p.A690T	BRD1_ENST00000457780.2_Missense_Mutation_p.A690T|BRD1_ENST00000404760.1_Missense_Mutation_p.A690T|BRD1_ENST00000342989.5_Missense_Mutation_p.A285T|BRD1_ENST00000404034.1_Missense_Mutation_p.A690T|BRD1_ENST00000542442.1_Missense_Mutation_p.A378T	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	690					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CGCCGCGGTGCCGCAGCAGGC	0.647													17	13					0	0	1	0	0	T	50191483	C	T	50191483	3	4	48	1	0	0	0	0	1	0	0	0	1503	739	26	3	1140	3	BRD1	22	50191483	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2904264	50191483	1113083	4206	8600										
TUBGCP6	85378	broad.mit.edu	37	chr22	50664759	50664759	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcacctgaatcatgaactcGccataagcgtctctgaacac	6	13	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:50664759G>A	ENST00000439308.2	-	8	2142	c.1650C>T	c.(1648-1650)ggC>ggT	p.G550G	TUBGCP6_ENST00000248846.5_Silent_p.G550G	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	550					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCATGAACTCGCCATAAGCGT	0.607													14	12					0	0	1	0	0	A	50664759	G	A	50664759	2	1	48	1	0	0	0	0	0	0	0	1	16831	1074	38	1		1	TUBGCP6	22	50664759	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	473276	50664759	639807	4207	8601										
CPT1B	1375	broad.mit.edu	37	chr22	51008020	51008020	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaccgtctctgagcttgaGaacttgctggagatgtggaa	12	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chr22:51008020G>T	ENST00000360719.2	-	18	2357	c.2220C>A	c.(2218-2220)ttC>ttA	p.F740L	CPT1B_ENST00000434492.2_Missense_Mutation_p.F535L|CPT1B_ENST00000440709.1_Missense_Mutation_p.F659L|CPT1B_ENST00000457250.1_Missense_Mutation_p.F706L|CPT1B_ENST00000312108.7_Missense_Mutation_p.F740L|CHKB-CPT1B_ENST00000453634.1_3'UTR|CPT1B_ENST00000395650.2_Missense_Mutation_p.F740L|CPT1B_ENST00000405237.3_Missense_Mutation_p.F740L	NM_001145135.1|NM_152245.2	NP_001138607.1|NP_689451.1	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B (muscle)	740					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		CTGAGCTTGAGAACTTGCTGG	0.562													23	18					6.44725e-10	7.85205e-10	1	1	0	T	51008020	G	T	51008020	3	4	48	1	0	0	0	0	1	0	0	0	3855	933	33	2	106	2	CPT1B	22	51008020	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	343261	51008020	296546	4208	8602										
CSF2RA	0	broad.mit.edu	37	chrX	1407680	1407680	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtaccgctgctcagaatttCtcctgtttcatctacaatgc	7	12	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:1407680C>A	ENST00000381524.3	+	6	558	c.372C>A	c.(370-372)ttC>ttA	p.F124L	CSF2RA_ENST00000417535.2_Missense_Mutation_p.F124L|CSF2RA_ENST00000381509.3_Missense_Mutation_p.F124L|CSF2RA_ENST00000501036.2_5'UTR|CSF2RA_ENST00000355432.3_Missense_Mutation_p.F124L|CSF2RA_ENST00000381500.1_Missense_Mutation_p.F124L|CSF2RA_ENST00000381529.3_Missense_Mutation_p.F124L|CSF2RA_ENST00000432318.2_Missense_Mutation_p.F124L|CSF2RA_ENST00000355805.2_Missense_Mutation_p.F124L|CSF2RA_ENST00000361536.3_Missense_Mutation_p.F124L			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	124						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CTCAGAATTTCTCCTGTTTCA	0.488													64	138					6.26901e-30	8.94914e-30	1	1	0	A	1407680	C	A	1407680	3	1	48	1	0	0	0	0	1	0	0	0	3959	912	32	2	386	2	CSF2RA	23	1407680	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08		1407680	153862880	4209	8603										
CSF2RA	0	broad.mit.edu	37	chrX	1428454	1428454	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttgatgatgctgtgaaccTttatatcattttctatgttt	6	6	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:1428454T>A	ENST00000355432.3	+	11	1255	c.1106T>A	c.(1105-1107)cTt>cAt	p.L369H	CSF2RA_ENST00000417535.2_3'UTR|CSF2RA_ENST00000381524.3_3'UTR|CSF2RA_ENST00000501036.2_3'UTR|CSF2RA_ENST00000498153.1_3'UTR|CSF2RA_ENST00000381500.1_3'UTR|CSF2RA_ENST00000381529.3_3'UTR|CSF2RA_ENST00000432318.2_3'UTR|CSF2RA_ENST00000355805.2_3'UTR|CSF2RA_ENST00000361536.3_3'UTR	NM_172246.2	NP_758449.1	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCTGTGAACCTTTATATCATT	0.502													17	114					0	0	1	0	0	A	1428454	T	A	1428454	3	1	48	1	0	0	0	0	1	0	0	0	3959	1609	56	4	1545	4	CSF2RA	23	1428454	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	20774	1428454	153842106	4210	8604										
IL3RA	3563	broad.mit.edu	37	chrX	1460715	1460715	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgccctgtctcctgcaaacGaaggaaggtaagaactggag	12	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:1460715G>A	ENST00000331035.4	+	2	406	c.57G>A	c.(55-57)acG>acA	p.T19T	IL3RA_ENST00000381469.2_Silent_p.T19T	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	19						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TCCTGCAAACGAAGGAAGGTA	0.587													39	113					0	0	1	0	0	A	1460715	G	A	1460715	2	1	48	1	0	0	0	0	0	0	0	1	7738	1045	37	1		1	IL3RA	23	1460715	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	32261	1460715	153809845	4211	8605										
IL3RA	3563	broad.mit.edu	37	chrX	1467357	1467357	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctattgccagtttggagcaAtttccttatgtgaagtgacc	10	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:1467357A>G	ENST00000331035.4	+	4	566	c.217A>G	c.(217-219)Att>Gtt	p.I73V	IL3RA_ENST00000381469.2_Intron	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	73						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GTTTGGAGCAATTTCCTTATG	0.453													94	166					0	0	1	0	0	G	1467357	A	G	1467357	3	3	48	1	0	0	0	0	1	0	0	0	7738	101	4	4	227	4	IL3RA	23	1467357	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	6642	1467357	153803203	4212	8606										
SLC25A6	293	broad.mit.edu	37	chrX	1506218	1506218	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcgccgccgcaccgtgtcGaaggggtaggacaccacgcc	14	15	0	0	rs147482209	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:1506218G>A	ENST00000381401.5	-	3	1407	c.693C>T	c.(691-693)ttC>ttT	p.F231F	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	231					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GCACCGTGTCGAAGGGGTAGG	0.682													28	76					0	0	1	0	0	A	1506218	G	A	1506218	2	1	48	1	0	0	0	0	0	0	0	1	14567	1049	37	1		1	SLC25A6	23	1506218	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	38861	1506218	153764342	4213	8607										
P2RY8	286530	broad.mit.edu	37	chrX	1584447	1584447	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagggtgcgcaccggcctcGgagcgcacggacgtggtcct	16	14	1	0	rs144046178	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:1584447G>A	ENST00000381297.4	-	2	1215	c.1005C>T	c.(1003-1005)tcC>tcT	p.S335S		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	335						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACCGGCCTCGGAGCGCACGG	0.701			T	CRLF2	"B-ALL, Downs associated ALL"								25	66					0	0	1	0	0	A	1584447	G	A	1584447	2	1	48	1	0	0	0	0	0	0	0	1	11401	1103	39	1		1	P2RY8	23	1584447	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	78229	1584447	153686113	4214	8608										
ARSD	414	broad.mit.edu	37	chrX	2835914	2835914	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagaaccatgggttgctccGtgacgtcatggtttctcatc	10	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:2835914G>A	ENST00000381154.1	-	5	869	c.794C>T	c.(793-795)aCg>aTg	p.T265M	ARSD_ENST00000217890.6_5'UTR	NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	265						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGTTGCTCCGTGACGTCATG	0.493													19	29					0	0	1	0	0	A	2835914	G	A	2835914	3	1	48	1	0	0	0	0	1	0	0	0	988	1145	40	1	1164	1	ARSD	23	2835914	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1251467	2835914	152434646	4215	8609										
ARSE	415	broad.mit.edu	37	chrX	2861177	2861177	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctagggaaccgccgtgatccGacgtaaaataaatgagggtg	13	8	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:2861177G>A	ENST00000545496.1	-	9	1421	c.1130C>T	c.(1129-1131)tCg>tTg	p.S377L	ARSE_ENST00000381134.3_Missense_Mutation_p.S352L|ARSE_ENST00000540563.1_Missense_Mutation_p.S307L			P51690	ARSE_HUMAN	arylsulfatase E (chondrodysplasia punctata 1)	352					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCCGTGATCCGACGTAAAATA	0.473													11	24					0	0	1	0	0	A	2861177	G	A	2861177	3	1	48	1	0	0	0	0	1	0	0	0	989	1059	37	1	730	1	ARSE	23	2861177	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25263	2861177	152409383	4216	8610										
ARSH	347527	broad.mit.edu	37	chrX	2947303	2947303	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaagagtgattgacggccaGaacctaatgcccctgctgga	11	12	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:2947303G>A	ENST00000381130.2	+	8	1215	c.1215G>A	c.(1213-1215)caG>caA	p.Q405Q		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	405						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTGACGGCCAGAACCTAATGC	0.542													5	145					0	0	1	0	0	A	2947303	G	A	2947303	2	1	48	1	0	0	0	0	0	0	0	1	992	933	33	3		3	ARSH	23	2947303	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	86126	2947303	152323257	4217	8611										
MXRA5	25878	broad.mit.edu	37	chrX	3238669	3238669	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagttcttcggtcagtaaacTtactaggaatgctgggtttg	11	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:3238669T>G	ENST00000217939.6	-	5	5211	c.5057A>C	c.(5056-5058)aAg>aCg	p.K1686T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1686						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCAGTAAACTTACTAGGAAT	0.438													82	141					0	0	1	0	0	G	3238669	T	G	3238669	3	3	48	1	0	0	0	0	1	0	0	0	10050	1609	56	4	3441	4	MXRA5	23	3238669	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	291366	3238669	152031891	4218	8612										
MXRA5	25878	broad.mit.edu	37	chrX	3240878	3240878	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgggctctggtgacgatcCaacatctgctgcagaccaac	11	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:3240878C>A	ENST00000217939.6	-	5	3002	c.2848G>T	c.(2848-2850)Gga>Tga	p.G950*		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	950						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTGACGATCCAACATCTGCT	0.507													35	52					7.65355e-07	8.68711e-07	1	1	0	A	3240878	C	A	3240878	4	1	48	1	0	0	0	0	0	1	0	0	10050	603	21	5	5650	5	MXRA5	23	3240878	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2209	3240878	152029682	4219	8613										
MXRA5	25878	broad.mit.edu	37	chrX	3242220	3242220	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggactctcagaagctttcacGttgcagctcaactggcatgg	11	11	3	1	rs151156772		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:3242220G>A	ENST00000217939.6	-	5	1660	c.1506C>T	c.(1504-1506)aaC>aaT	p.N502N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	502	Ig-like C2-type 1.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAGCTTTCACGTTGCAGCTCA	0.542													50	96					0	0	1	0	0	A	3242220	G	A	3242220	2	1	48	1	0	0	0	0	0	0	0	1	10050	1136	40	1		1	MXRA5	23	3242220	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1342	3242220	152028340	4220	8614										
NLGN4X	57502	broad.mit.edu	37	chrX	5811614	5811614	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatgcagatagagctggtcTttgggattatacttggacca	11	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:5811614T>G	ENST00000381095.3	-	6	2322	c.1695A>C	c.(1693-1695)aaA>aaC	p.K565N	NLGN4X_ENST00000381092.1_Missense_Mutation_p.K565N|NLGN4X_ENST00000381093.2_Missense_Mutation_p.K585N|NLGN4X_ENST00000275857.6_Missense_Mutation_p.K565N|NLGN4X_ENST00000538097.1_Missense_Mutation_p.K565N	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	565					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AGAGCTGGTCTTTGGGATTAT	0.468													38	91					0	0	1	0	0	G	5811614	T	G	5811614	3	3	48	1	0	0	0	0	1	0	0	0	10510	1606	56	4	759	4	NLGN4X	23	5811614	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2569394	5811614	149458946	4221	8615										
NLGN4X	57502	broad.mit.edu	37	chrX	5821807	5821807	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtccagcatgttgcagccGaccttgtctgccaatatccg	10	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:5821807G>A	ENST00000381095.3	-	5	1539	c.912C>T	c.(910-912)gtC>gtT	p.V304V	NLGN4X_ENST00000381092.1_Silent_p.V304V|NLGN4X_ENST00000381093.2_Silent_p.V324V|NLGN4X_ENST00000275857.6_Silent_p.V304V|NLGN4X_ENST00000538097.1_Silent_p.V304V	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	304					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TGTTGCAGCCGACCTTGTCTG	0.577													48	84					0	0	1	0	0	A	5821807	G	A	5821807	2	1	48	1	0	0	0	0	0	0	0	1	10510	1045	37	1		1	NLGN4X	23	5821807	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10193	5821807	149448753	4222	8616										
KAL1	3730	broad.mit.edu	37	chrX	8553380	8553380	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacattcacagcagccactcGaaactggtaccatcggctgg	9	14	1	0	rs137852516		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:8553380G>A	ENST00000262648.3	-	6	933	c.784C>T	c.(784-786)Cga>Tga	p.R262*		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	262	Fibronectin type-III 1.		R -> P (in KAL1).		axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GCAGCCACTCGAAACTGGTAC	0.512													28	37					0	0	1	0	0	A	8553380	G	A	8553380	4	1	48	1	0	0	0	0	0	1	0	0	8017	1066	37	1	1294	1	KAL1	23	8553380	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2731573	8553380	146717180	4223	8617										
GPR143	4935	broad.mit.edu	37	chrX	9709432	9709432	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaggtttcaaagaacctccAttgatatctgtttgcatctc	6	10	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:9709432A>G	ENST00000467482.1	-	7	977	c.831T>C	c.(829-831)aaT>aaC	p.N277N	GPR143_ENST00000380929.2_Silent_p.N297N			P51810	GP143_HUMAN	G protein-coupled receptor 143	277					calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Hepatocellular(5;0.000888)				AAGAACCTCCATTGATATCTG	0.318													6	12					0	0	1	0	0	G	9709432	A	G	9709432	2	3	48	1	0	0	0	0	0	0	0	1	6690	214	8	4		4	GPR143	23	9709432	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1156052	9709432	145561128	4224	8618										
SHROOM2	357	broad.mit.edu	37	chrX	9862500	9862500	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttgacagcctggaccacccCtccagtcgcctctcggtggc	11	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:9862500C>A	ENST00000380913.3	+	4	642	c.552C>A	c.(550-552)ccC>ccA	p.P184P		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	184					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				TGGACCACCCCTCCAGTCGCC	0.622													23	44					3.8784e-16	5.13982e-16	1	1	0	A	9862500	C	A	9862500	2	1	48	1	0	0	0	0	0	0	0	1	14348	668	24	5		5	SHROOM2	23	9862500	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	153068	9862500	145408060	4225	8619										
CLCN4	0	broad.mit.edu	37	chrX	10174814	10174814	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgtgcttttcagtctagaaGaggtgagaatgggcagctga	15	6	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:10174814G>T	ENST00000380833.4	+	8	1232	c.841G>T	c.(841-843)Gag>Tag	p.E281*	CLCN4_ENST00000380829.1_Nonsense_Mutation_p.E281*|CLCN4_ENST00000421085.2_Nonsense_Mutation_p.E187*	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	281		Mediates proton transfer from the protein to the inner aqueous phase.				early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CAGTCTAGAAGAGGTGAGAAT	0.468													45	84					3.4345e-17	4.60033e-17	1	1	0	T	10174814	G	T	10174814	4	4	48	1	0	0	0	0	0	1	0	0	3488	943	33	2	863	2	CLCN4	23	10174814	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	312314	10174814	145095746	4226	8620										
MID1	0	broad.mit.edu	37	chrX	10491182	10491182	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agccaaaagggtctccagttCtgtgttcctcttaataaggt	9	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:10491182C>A	ENST00000317552.4	-	3	1106	c.706G>T	c.(706-708)Gaa>Taa	p.E236*	MID1_ENST00000380779.1_Nonsense_Mutation_p.E236*|MID1_ENST00000453318.2_Nonsense_Mutation_p.E236*|MID1_ENST00000380780.1_Nonsense_Mutation_p.E236*|MID1_ENST00000380782.2_Nonsense_Mutation_p.E236*|MID1_ENST00000380785.1_Nonsense_Mutation_p.E236*|MID1_ENST00000380787.1_Nonsense_Mutation_p.E236*	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	236					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						GTCTCCAGTTCTGTGTTCCTC	0.338													46	63					3.21987e-24	4.51617e-24	1	1	0	A	10491182	C	A	10491182	4	1	48	1	0	0	0	0	0	1	0	0	9623	922	32	2	1329	2	MID1	23	10491182	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	316368	10491182	144779378	4227	8621										
HCCS	3052	broad.mit.edu	37	chrX	11139034	11139034	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggggaattctagagagtgtCcttgtggtccatcattgatc	12	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:11139034C>T	ENST00000321143.4	+	6	731	c.529C>T	c.(529-531)Cct>Tct	p.P177S	HCCS_ENST00000380763.3_Missense_Mutation_p.P177S|ARHGAP6_ENST00000534860.1_Intron|HCCS_ENST00000380762.4_Missense_Mutation_p.P177S	NM_001122608.2|NM_001171991.2|NM_005333.4	NP_001116080.1|NP_001165462.1|NP_005324.3	P53701	CCHL_HUMAN	holocytochrome c synthase	177					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)	7						TAGAGAGTGTCCTTGTGGTCC	0.383													33	147					0	0	1	0	0	T	11139034	C	T	11139034	3	4	48	1	0	0	0	0	1	0	0	0	7030	855	30	3	547	3	HCCS	23	11139034	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	647852	11139034	144131526	4228	8622										
ARHGAP6	395	broad.mit.edu	37	chrX	11162029	11162029	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagaaggtccgaagagccccAcaccatgccacatgcaacaa	9	14	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:11162029A>G	ENST00000380718.1	-	11	3119	c.2247T>C	c.(2245-2247)tgT>tgC	p.C749C	ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000380736.1_Intron|ARHGAP6_ENST00000534860.1_Intron|ARHGAP6_ENST00000303025.6_Intron	NM_006125.2	NP_006116.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	0					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GAAGAGCCCCACACCATGCCA	0.522											OREG0019666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	119	244					0	0	1	0	0	G	11162029	A	G	11162029	2	3	48	1	0	0	0	0	0	0	0	1	884	157	6	4		4	ARHGAP6	23	11162029	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	22995	11162029	144108531	4229	8623										
ARHGAP6	395	broad.mit.edu	37	chrX	11187706	11187706	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctcagcccgggctgaactCtgaactgagaattctttgtc	9	12	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:11187706C>A	ENST00000337414.4	-	9	2600	c.1728G>T	c.(1726-1728)caG>caT	p.Q576H	ARHGAP6_ENST00000413512.3_Missense_Mutation_p.Q385H|ARHGAP6_ENST00000380736.1_Missense_Mutation_p.Q373H|ARHGAP6_ENST00000380718.1_Missense_Mutation_p.Q576H|ARHGAP6_ENST00000491514.1_5'UTR|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.Q608H|ARHGAP6_ENST00000534860.1_Missense_Mutation_p.Q401H|ARHGAP6_ENST00000303025.6_Missense_Mutation_p.Q373H	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	576	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GGGCTGAACTCTGAACTGAGA	0.473													17	63					8.60227e-14	1.10942e-13	1	1	0	A	11187706	C	A	11187706	3	1	48	1	0	0	0	0	1	0	0	0	884	912	32	2	1338	2	ARHGAP6	23	11187706	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	25677	11187706	144082854	4230	8624										
ARHGAP6	395	broad.mit.edu	37	chrX	11682852	11682852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtccaggctgcgggtctggcGcagcttcctcttggagaagc	15	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:11682852G>A	ENST00000337414.4	-	1	969	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C	ARHGAP6_ENST00000380718.1_Missense_Mutation_p.R33C|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.R33C	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	33					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CGGGTCTGGCGCAGCTTCCTC	0.721													5	10					0	0	1	0	0	A	11682852	G	A	11682852	3	1	48	1	0	0	0	0	1	0	0	0	884	1087	38	1	3001	1	ARHGAP6	23	11682852	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	495146	11682852	143587708	4231	8625										
TLR8	51311	broad.mit.edu	37	chrX	12938499	12938499	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatgcaaatagttcctcttTtcaacgtcatatccggaaac	5	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:12938499T>C	ENST00000218032.6	+	2	1427	c.1340T>C	c.(1339-1341)tTt>tCt	p.F447S	TLR8_ENST00000311912.5_Missense_Mutation_p.F465S	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	447					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AGTTCCTCTTTTCAACGTCAT	0.378													43	18					0	0	1	0	0	C	12938499	T	C	12938499	3	2	48	1	0	0	0	0	1	0	0	0	16016	1841	64	4	1346	4	TLR8	23	12938499	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1255647	12938499	142332061	4232	8626										
ATXN3L	92552	broad.mit.edu	37	chrX	13337045	13337045	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctaaaatggtgtcgacagCggcctgtactgtgccttcac	10	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:13337045C>T	ENST00000380622.2	-	1	1473	c.1009G>A	c.(1009-1011)Gct>Act	p.A337T	GS1-600G8.3_ENST00000431486.1_RNA	NM_001135995.1	NP_001129467.1	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	337					protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						GTGTCGACAGCGGCCTGTACT	0.393													37	38					0	0	1	0	0	T	13337045	C	T	13337045	3	4	48	1	0	0	0	0	1	0	0	0	1212	768	27	1	62	1	ATXN3L	23	13337045	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	398546	13337045	141933515	4233	8627										
ATXN3L	92552	broad.mit.edu	37	chrX	13337601	13337601	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttgttgtaatcgagccaaGaaatttgcaaggcatgtatc	10	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:13337601G>T	ENST00000380622.2	-	1	917	c.453C>A	c.(451-453)ttC>ttA	p.F151L	GS1-600G8.3_ENST00000431486.1_RNA	NM_001135995.1	NP_001129467.1	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	151	Josephin.				protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity	p.F151L(1)		endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						ATCGAGCCAAGAAATTTGCAA	0.398													17	17					1.5739e-10	1.93697e-10	1	1	0	T	13337601	G	T	13337601	3	4	48	1	0	0	0	0	1	0	0	0	1212	933	33	2	618	2	ATXN3L	23	13337601	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	556	13337601	141932959	4234	8628										
PIGA	5277	broad.mit.edu	37	chrX	15344081	15344081	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaacttcttccaaaatgattCtctttggtccctctcctcca	4	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:15344081C>A	ENST00000333590.4	-	3	887	c.803G>T	c.(802-804)aGa>aTa	p.R268I	PIGA_ENST00000542278.1_Missense_Mutation_p.R34I|PIGA_ENST00000482148.1_Intron|PIGA_ENST00000428964.1_5'UTR	NM_002641.3	NP_002632.1	P37287	PIGA_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class A	268					C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Hepatocellular(33;0.183)					CAAAATGATTCTCTTTGGTCC	0.358													33	78					1.56442e-22	2.17472e-22	1	1	0	A	15344081	C	A	15344081	3	1	48	1	0	0	0	0	1	0	0	0	11931	913	32	2	667	2	PIGA	23	15344081	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2006480	15344081	139926479	4235	8629										
PIGA	5277	broad.mit.edu	37	chrX	15349745	15349745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gactgtgaaagagggtcgtgGctgtagactggttgtacatg	16	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:15349745G>A	ENST00000333590.4	-	2	392	c.308C>T	c.(307-309)gCc>gTc	p.A103V	PIGA_ENST00000542278.1_Intron|PIGA_ENST00000482148.1_5'UTR|PIGA_ENST00000428964.1_Intron	NM_002641.3	NP_002632.1	P37287	PIGA_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class A	103					C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Hepatocellular(33;0.183)					GAGGGTCGTGGCTGTAGACTG	0.458													42	91					0	0	1	0	0	A	15349745	G	A	15349745	3	1	48	1	0	0	0	0	1	0	0	0	11931	1203	42	3	1166	3	PIGA	23	15349745	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	5664	15349745	139920815	4236	8630										
PIGA	5277	broad.mit.edu	37	chrX	15350106	15350106	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccagttaagagatgtgtcCtctattacctgaaaaagagt	8	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:15350106C>A	ENST00000333590.4	-	0	31				PIGA_ENST00000542278.1_Intron|PIGA_ENST00000482148.1_5'UTR|PIGA_ENST00000428964.1_De_novo_Start_InFrame	NM_002641.3	NP_002632.1	P37287	PIGA_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class A						C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Hepatocellular(33;0.183)					GAGATGTGTCCTCTATTACCT	0.408													12	26					0.000978159	0.00102903	1	1	0	A	15350106	C	A	15350106	1	1	48	1	0	0	0	0	0	0	0	0	11931	696	24	5		5	PIGA	23	15350106	Translation_Start_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	361	15350106	139920454	4237	8631										
BMX	660	broad.mit.edu	37	chrX	15549500	15549500	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgagccaagtgggaatgtAcacagtgtccttatttagta	10	7	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:15549500A>G	ENST00000357607.2	+	11	1177	c.989A>G	c.(988-990)tAc>tGc	p.Y330C	BMX_ENST00000342014.6_Missense_Mutation_p.Y330C|BMX_ENST00000348343.6_Missense_Mutation_p.Y330C			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	330	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					GTGGGAATGTACACAGTGTCC	0.338													36	70					0	0	1	0	0	G	15549500	A	G	15549500	3	3	48	1	0	0	0	0	1	0	0	0	1472	391	14	4	1027	4	BMX	23	15549500	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	199394	15549500	139721060	4238	8632										
ACE2	59272	broad.mit.edu	37	chrX	15589793	15589793	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaaaagaattcttgttctgGtctttcagccaggtaaataa	7	7	4	1	rs145437639	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:15589793G>C	ENST00000427411.1	-	14	2007	c.1791C>G	c.(1789-1791)gaC>gaG	p.D597E	ACE2_ENST00000252519.3_Missense_Mutation_p.D597E	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	597					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	TCTTGTTCTGGTCTTTCAGCC	0.453													43	85					0	0	1	0	0	C	15589793	G	C	15589793	3	2	48	1	0	0	0	0	1	0	0	0	137	1252	44	5	650	5	ACE2	23	15589793	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	40293	15589793	139680767	4239	8633										
CA5B	11238	broad.mit.edu	37	chrX	15800776	15800776	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaagccggccaccagccaaGcaaccccctaaaacattcat	5	18	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:15800776G>A	ENST00000318636.3	+	8	1079	c.943G>A	c.(943-945)Gca>Aca	p.A315T	CA5B_ENST00000454127.2_Missense_Mutation_p.A315T	NM_007220.3	NP_009151.1	Q9Y2D0	CAH5B_HUMAN	carbonic anhydrase VB, mitochondrial	315					one-carbon metabolic process	mitochondrion	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(2)|lung(3)|prostate(1)|stomach(2)	9	Hepatocellular(33;0.183)					CACCAGCCAAGCAACCCCCTA	0.438													18	59					0	0	1	0	0	A	15800776	G	A	15800776	3	1	48	1	0	0	0	0	1	0	0	0	2538	971	34	3	969	3	CA5B	23	15800776	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	210983	15800776	139469784	4240	8634										
GRPR	2925	broad.mit.edu	37	chrX	16170395	16170395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagattgaatcccggaagcGacttgccaagacagtgctgg	12	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:16170395G>A	ENST00000380289.2	+	3	1180	c.782G>A	c.(781-783)cGa>cAa	p.R261Q		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	261					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					TCCCGGAAGCGACTTGCCAAG	0.517													47	91					0	0	1	0	0	A	16170395	G	A	16170395	3	1	48	1	0	0	0	0	1	0	0	0	6848	1058	37	1	792	1	GRPR	23	16170395	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	369619	16170395	139100165	4241	8635										
REPS2	9185	broad.mit.edu	37	chrX	17153397	17153397	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccacaggatgtactgtattCtcagccaccatcaaagccca	6	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:17153397C>A	ENST00000357277.3	+	16	1847	c.1676C>A	c.(1675-1677)tCt>tAt	p.S559Y	REPS2_ENST00000303843.7_Missense_Mutation_p.S558Y|REPS2_ENST00000469714.1_3'UTR|REPS2_ENST00000380064.4_Missense_Mutation_p.S358Y	NM_001080975.1|NM_004726.2	NP_001074444.1|NP_004717.2	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	559	Interaction with RALBP1.				epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(3)|urinary_tract(1)	17	Hepatocellular(33;0.183)					GTACTGTATTCTCAGCCACCA	0.423													99	181					3.11363e-52	4.52285e-52	1	1	0	A	17153397	C	A	17153397	3	1	48	1	0	0	0	0	1	0	0	0	13280	913	32	2	1738	2	REPS2	23	17153397	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	983002	17153397	138117163	4242	8636										
NHS	4810	broad.mit.edu	37	chrX	17746280	17746280	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttatgagccgccaccatgacAaagtgcctggtactatcagc	9	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:17746280A>G	ENST00000380060.3	+	6	4329	c.3991A>G	c.(3991-3993)Aaa>Gaa	p.K1331E	NHS_ENST00000398097.3_Missense_Mutation_p.K1175E	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1331						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CCACCATGACAAAGTGCCTGG	0.393													38	86					0	0	1	0	0	G	17746280	A	G	17746280	3	3	48	1	0	0	0	0	1	0	0	0	10457	131	5	4	4118	4	NHS	23	17746280	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	592883	17746280	137524280	4243	8637										
BEND2	139105	broad.mit.edu	37	chrX	18230697	18230697	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatctacctctggagtataGaatcttcctctttttggaaa	6	8	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:18230697G>T	ENST00000380033.4	-	4	612	c.480C>A	c.(478-480)ttC>ttA	p.F160L	BEND2_ENST00000380030.3_Missense_Mutation_p.F160L	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	160								p.F160F(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						CTGGAGTATAGAATCTTCCTC	0.328													4	49					0.00024832	0.000265255	1	1	0	T	18230697	G	T	18230697	3	4	48	1	0	0	0	0	1	0	0	0	1396	933	33	2	1989	2	BEND2	23	18230697	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	484417	18230697	137039863	4244	8638										
SCML2	10389	broad.mit.edu	37	chrX	18260638	18260638	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtatcacttcatccacaGaccaggttgaagggtcctta	8	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:18260638G>T	ENST00000251900.4	-	14	2054	c.1895C>A	c.(1894-1896)tCt>tAt	p.S632Y	SCML2_ENST00000398048.3_Intron	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	632	SAM.				anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					TTCATCCACAGACCAGGTTGA	0.458													13	84					1.5842e-08	1.87418e-08	1	1	0	T	18260638	G	T	18260638	3	4	48	1	0	0	0	0	1	0	0	0	13963	942	33	2	215	2	SCML2	23	18260638	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	29941	18260638	137009922	4245	8639										
CDKL5	6792	broad.mit.edu	37	chrX	18622738	18622738	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgaaccacaaccagacattCtaagacgatggaggaattga	9	9	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:18622738C>A	ENST00000379989.3	+	13	1979	c.1694C>A	c.(1693-1695)tCt>tAt	p.S565Y	CDKL5_ENST00000379996.3_Missense_Mutation_p.S565Y|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	565					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					ACCAGACATTCTAAGACGATG	0.502													13	154					0.00010058	0.000108553	1	1	0	A	18622738	C	A	18622738	3	1	48	1	0	0	0	0	1	0	0	0	3179	913	32	2	1736	2	CDKL5	23	18622738	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	362100	18622738	136647822	4246	8640										
CDKL5	6792	broad.mit.edu	37	chrX	18626974	18626974	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgactgtggcaagatcttCggtcaaagagacctccagag	12	9	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:18626974C>T	ENST00000379989.3	+	14	2273	c.1988C>T	c.(1987-1989)tCg>tTg	p.S663L	CDKL5_ENST00000379996.3_Missense_Mutation_p.S663L|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	663					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					GCAAGATCTTCGGTCAAAGAG	0.438													4	41					0	0	1	0	0	T	18626974	C	T	18626974	3	4	48	1	0	0	0	0	1	0	0	0	3179	893	31	1	2034	1	CDKL5	23	18626974	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4236	18626974	136643586	4247	8641										
CDKL5	6792	broad.mit.edu	37	chrX	18638065	18638065	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttttcaggtcaatgaaaaaGaaaaagaagaaatctcaaac	6	5	3	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:18638065G>T	ENST00000379989.3	+	17	2640	c.2355G>T	c.(2353-2355)aaG>aaT	p.K785N	CDKL5_ENST00000379996.3_Missense_Mutation_p.K785N|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	785	Poly-Lys.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					CAATGAAAAAGAAAAAGAAGA	0.308													7	8					8.12818e-05	8.79784e-05	1	1	0	T	18638065	G	T	18638065	3	4	48	1	0	0	0	0	1	0	0	0	3179	933	33	2	2413	2	CDKL5	23	18638065	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11091	18638065	136632495	4248	8642										
GPR64	10149	broad.mit.edu	37	chrX	19009003	19009003	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatttgctcaataaagtgTaagcttccccgctttgaagt	7	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:19009003T>C	ENST00000379878.3	-	28	3226	c.2985A>G	c.(2983-2985)ttA>ttG	p.L995L	GPR64_ENST00000379876.1_Silent_p.L987L|GPR64_ENST00000356606.4_Silent_p.L997L|GPR64_ENST00000379873.2_Silent_p.L960L|GPR64_ENST00000357544.3_Silent_p.L981L|GPR64_ENST00000360279.4_Silent_p.L989L|GPR64_ENST00000357991.3_Silent_p.L1008L|GPR64_ENST00000354791.3_Silent_p.L995L|GPR64_ENST00000340581.3_Silent_p.L892L|GPR64_ENST00000379869.3_Silent_p.L1011L	NM_001184833.1	NP_001171762.1	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	1011					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					CAATAAAGTGTAAGCTTCCCC	0.398													38	62					0	0	1	0	0	C	19009003	T	C	19009003	2	2	48	1	0	0	0	0	0	0	0	1	6744	1635	57	4		4	GPR64	23	19009003	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	370938	19009003	136261557	4249	8643										
GPR64	10149	broad.mit.edu	37	chrX	19032031	19032031	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccctattggagagggaacaTtgtgggtcacaggtgaataa	13	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:19032031T>G	ENST00000379878.3	-	15	1065	c.824A>C	c.(823-825)aAt>aCt	p.N275T	GPR64_ENST00000379876.1_Missense_Mutation_p.N267T|GPR64_ENST00000356606.4_Missense_Mutation_p.N277T|GPR64_ENST00000379873.2_Missense_Mutation_p.N291T|GPR64_ENST00000357544.3_Missense_Mutation_p.N261T|GPR64_ENST00000360279.4_Missense_Mutation_p.N269T|GPR64_ENST00000357991.3_Missense_Mutation_p.N288T|GPR64_ENST00000354791.3_Missense_Mutation_p.N275T|GPR64_ENST00000340581.3_Missense_Mutation_p.N261T|GPR64_ENST00000379869.3_Missense_Mutation_p.N291T	NM_001184833.1	NP_001171762.1	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	291					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					AGAGGGAACATTGTGGGTCAC	0.557													75	114					0	0	1	0	0	G	19032031	T	G	19032031	3	3	48	1	0	0	0	0	1	0	0	0	6744	1493	52	4	2237	4	GPR64	23	19032031	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23028	19032031	136238529	4250	8644										
MAP3K15	389840	broad.mit.edu	37	chrX	19379463	19379463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgaggctcttaccgtagtCgaaggtatcttagatcttcc	9	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:19379463C>T	ENST00000338883.4	-	28	3850	c.3851G>A	c.(3850-3852)cGa>cAa	p.R1284Q	PDHA1_ENST00000422285.2_3'UTR|PDHA1_ENST00000545074.1_3'UTR|PDHA1_ENST00000379806.5_3'UTR|MAP3K15_ENST00000469203.2_Missense_Mutation_p.R1116Q|MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000359173.3_Missense_Mutation_p.R719Q|PDHA1_ENST00000540249.1_3'UTR	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	1284							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					TTACCGTAGTCGAAGGTATCT	0.393													10	22					0	0	1	0	0	T	19379463	C	T	19379463	3	4	48	1	0	0	0	0	1	0	0	0	9298	884	31	1	98	1	MAP3K15	23	19379463	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	347432	19379463	135891097	4251	8645										
SH3KBP1	30011	broad.mit.edu	37	chrX	19560162	19560162	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttggttttccttccgtgccGaacagagacggggagttggc	14	9	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:19560162G>A	ENST00000397821.3	-	16	2063	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	SH3KBP1_ENST00000379698.4_Silent_p.F554F|SH3KBP1_ENST00000541422.1_Silent_p.F330F|SH3KBP1_ENST00000379716.1_Silent_p.F353F	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	591					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						CTTCCGTGCCGAACAGAGACG	0.647													23	104					0	0	1	0	0	A	19560162	G	A	19560162	2	1	48	1	0	0	0	0	0	0	0	1	14309	1049	37	1		1	SH3KBP1	23	19560162	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	180699	19560162	135710398	4252	8646										
SH3KBP1	30011	broad.mit.edu	37	chrX	19725022	19725022	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcctaccacctctatgatgtCgccaactttcagctcaagtt	5	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:19725022C>T	ENST00000397821.3	-	4	657	c.367G>A	c.(367-369)Gac>Aac	p.D123N	SH3KBP1_ENST00000379697.3_Missense_Mutation_p.D123N|SH3KBP1_ENST00000379698.4_Missense_Mutation_p.D86N	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	123	SH3 2.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						TCTATGATGTCGCCAACTTTC	0.572													17	40					0	0	1	0	0	T	19725022	C	T	19725022	3	4	48	1	0	0	0	0	1	0	0	0	14309	884	31	1	1706	1	SH3KBP1	23	19725022	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	164860	19725022	135545538	4253	8647										
CXorf23	256643	broad.mit.edu	37	chrX	19947913	19947913	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaactaaccttcttttttCtcattaatctttctctgaac	1	11	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:19947913C>A	ENST00000379687.3	-	10	2042	c.2009G>T	c.(2008-2010)aGa>aTa	p.R670I	CXorf23_ENST00000466702.1_5'UTR|CXorf23_ENST00000356980.3_3'UTR|CXorf23_ENST00000379682.4_Missense_Mutation_p.R699I	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	699						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						CTTCTTTTTTCTCATTAATCT	0.323													37	72					3.6622e-26	5.17531e-26	1	1	0	A	19947913	C	A	19947913	3	1	48	1	0	0	0	0	1	0	0	0	4126	913	32	2	47	2	CXorf23	23	19947913	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	222891	19947913	135322647	4254	8648										
MAP7D2	256714	broad.mit.edu	37	chrX	20043155	20043155	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcttttcagccaagatcttCgcagcctctcctgcatcagt	6	15	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:20043155C>T	ENST00000379651.3	-	9	1221	c.1203G>A	c.(1201-1203)gcG>gcA	p.A401A	MAP7D2_ENST00000466145.1_5'UTR|MAP7D2_ENST00000543767.1_Silent_p.A286A|MAP7D2_ENST00000452324.3_Silent_p.A349A|MAP7D2_ENST00000443379.3_Silent_p.A356A|MAP7D2_ENST00000379643.5_Silent_p.A442A	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	401										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						CCAAGATCTTCGCAGCCTCTC	0.522													52	93					0	0	1	0	0	T	20043155	C	T	20043155	2	4	48	1	0	0	0	0	0	0	0	1	9317	871	31	1		1	MAP7D2	23	20043155	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	95242	20043155	135227405	4255	8649										
MAP7D2	256714	broad.mit.edu	37	chrX	20060638	20060638	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttggatatcacaggagaaGatggtctcttaggaatgcct	11	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:20060638G>T	ENST00000379651.3	-	7	884	c.866C>A	c.(865-867)tCt>tAt	p.S289Y	MAP7D2_ENST00000543767.1_Missense_Mutation_p.S174Y|MAP7D2_ENST00000452324.3_Missense_Mutation_p.S237Y|MAP7D2_ENST00000443379.3_Missense_Mutation_p.S244Y|MAP7D2_ENST00000379643.5_Missense_Mutation_p.S330Y	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	289										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						CACAGGAGAAGATGGTCTCTT	0.502													84	147					3.49902e-48	5.0748e-48	1	1	0	T	20060638	G	T	20060638	3	4	48	1	0	0	0	0	1	0	0	0	9317	942	33	2	1368	2	MAP7D2	23	20060638	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	17483	20060638	135209922	4256	8650										
SMS	6611	broad.mit.edu	37	chrX	22003283	22003283	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccacatgggagtttctcaGactgattcttgacctctcaa	7	11	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:22003283G>A	ENST00000404933.2	+	9	1139	c.887G>A	c.(886-888)aGa>aAa	p.R296K	SMS_ENST00000415881.2_Missense_Mutation_p.R200K|SMS_ENST00000379404.1_Missense_Mutation_p.R243K	NM_004595.4	NP_004586.2	P52788	SPSY_HUMAN	spermine synthase	296					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(2)	14					Spermine(DB00127)	GAGTTTCTCAGACTGATTCTT	0.348													14	35					0	0	1	0	0	A	22003283	G	A	22003283	3	1	48	1	0	0	0	0	1	0	0	0	14866	942	33	3	921	3	SMS	23	22003283	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1942645	22003283	133267277	4257	8651										
ZNF645	158506	broad.mit.edu	37	chrX	22291306	22291306	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgatttgcctattaaaatCtatgggcgaataattccgtg	9	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:22291306C>A	ENST00000323684.1	+	1	242	c.198C>A	c.(196-198)atC>atA	p.I66I		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	66						intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						CTATTAAAATCTATGGGCGAA	0.383													29	56					4.87955e-14	6.31333e-14	1	1	0	A	22291306	C	A	22291306	2	1	48	1	0	0	0	0	0	0	0	1	18117	903	32	2		2	ZNF645	23	22291306	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	288023	22291306	132979254	4258	8652										
PTCHD1	139411	broad.mit.edu	37	chrX	23397857	23397857	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagaatgctcgggccaccaaTcggaccaattttgctatcac	8	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:23397857T>C	ENST00000379361.4	+	2	1361	c.501T>C	c.(499-501)aaT>aaC	p.N167N		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	167					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						GGGCCACCAATCGGACCAATT	0.488													27	132					0	0	1	0	0	C	23397857	T	C	23397857	2	2	48	1	0	0	0	0	0	0	0	1	12780	1432	50	4		4	PTCHD1	23	23397857	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1106551	23397857	131872703	4259	8653										
CXorf58	254158	broad.mit.edu	37	chrX	23953371	23953371	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcagaaataacagctggcGcaaattaaatcttgaaaata	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:23953371G>A	ENST00000379211.3	+	7	1163	c.614G>A	c.(613-615)cGc>cAc	p.R205H		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	205										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						AACAGCTGGCGCAAATTAAAT	0.418													55	87					0	0	1	0	0	A	23953371	G	A	23953371	3	1	48	1	0	0	0	0	1	0	0	0	4137	1087	38	1	636	1	CXorf58	23	23953371	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	555514	23953371	131317189	4260	8654										
KLHL15	80311	broad.mit.edu	37	chrX	24006621	24006621	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catatttgttaactggataaGgatccacaaattcccattta	5	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:24006621G>A	ENST00000328046.8	-	4	1487	c.1232C>T	c.(1231-1233)cCt>cTt	p.P411L		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	411										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						AACTGGATAAGGATCCACAAA	0.428													44	68					0	0	1	0	0	A	24006621	G	A	24006621	3	1	48	1	0	0	0	0	1	0	0	0	8413	1000	35	3	586	3	KLHL15	23	24006621	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	53250	24006621	131263939	4261	8655										
KLHL15	80311	broad.mit.edu	37	chrX	24024277	24024277	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccaagtaagacatgagcttCtcaaagctcagataggacag	9	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:24024277C>A	ENST00000328046.8	-	3	789	c.534G>T	c.(532-534)gaG>gaT	p.E178D		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	178	BACK.									autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						ACATGAGCTTCTCAAAGCTCA	0.478													44	76					1.15183e-24	1.61878e-24	1	1	0	A	24024277	C	A	24024277	3	1	48	1	0	0	0	0	1	0	0	0	8413	912	32	2	1288	2	KLHL15	23	24024277	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	17656	24024277	131246283	4262	8656										
ZFX	7543	broad.mit.edu	37	chrX	24228960	24228960	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatgctcttatccaccaaGaaagcaaaacacaccagtgt	5	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:24228960G>T	ENST00000379177.1	+	11	2312	c.1885G>T	c.(1885-1887)Gaa>Taa	p.E629*	ZFX_ENST00000338565.3_Nonsense_Mutation_p.E579*|ZFX_ENST00000540034.1_Nonsense_Mutation_p.E668*|ZFX_ENST00000539115.1_Nonsense_Mutation_p.E400*|ZFX_ENST00000304543.5_Nonsense_Mutation_p.E629*|ZFX_ENST00000379188.3_Nonsense_Mutation_p.E629*	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	629					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						TATCCACCAAGAAAGCAAAAC	0.418													32	69					2.85442e-18	3.86477e-18	1	1	0	T	24228960	G	T	24228960	4	4	48	1	0	0	0	0	0	1	0	0	17718	943	33	2	1970	2	ZFX	23	24228960	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	204683	24228960	131041600	4263	8657										
IL1RAPL1	11141	broad.mit.edu	37	chrX	29414549	29414549	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccaaccagagaacctgaaatCctttggtacaaggtatggac	9	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:29414549C>A	ENST00000378993.1	+	4	1210	c.537C>A	c.(535-537)atC>atA	p.I179I	IL1RAPL1_ENST00000302196.4_Silent_p.I179I	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	179	Ig-like C2-type 2.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AACCTGAAATCCTTTGGTACA	0.378													28	79					1.88708e-17	2.5355e-17	1	1	0	A	29414549	C	A	29414549	2	1	48	1	0	0	0	0	0	0	0	1	7704	845	30	2		2	IL1RAPL1	23	29414549	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5185589	29414549	125856011	4264	8658										
IL1RAPL1	11141	broad.mit.edu	37	chrX	29938105	29938105	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggggaacaggaagtttccatCtcattaattgtggactctgt	11	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:29938105C>A	ENST00000378993.1	+	8	1624	c.951C>A	c.(949-951)atC>atA	p.I317I	IL1RAPL1_ENST00000302196.4_Silent_p.I317I	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	317	Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AAGTTTCCATCTCATTAATTG	0.393													33	54					1.30998e-17	1.76095e-17	1	1	0	A	29938105	C	A	29938105	2	1	48	1	0	0	0	0	0	0	0	1	7704	903	32	2		2	IL1RAPL1	23	29938105	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	523556	29938105	125332455	4265	8659										
IL1RAPL1	11141	broad.mit.edu	37	chrX	29959904	29959904	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cattttggagctgaagagctCgatggaggtaggatgttacc	14	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:29959904C>T	ENST00000378993.1	+	9	1867	c.1194C>T	c.(1192-1194)ctC>ctT	p.L398L	IL1RAPL1_ENST00000302196.4_Silent_p.L398L	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	398					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						CTGAAGAGCTCGATGGAGGTA	0.358													18	49					0	0	1	0	0	T	29959904	C	T	29959904	2	4	48	1	0	0	0	0	0	0	0	1	7704	871	31	1		1	IL1RAPL1	23	29959904	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	21799	29959904	125310656	4266	8660										
MAGEB3	4114	broad.mit.edu	37	chrX	30254099	30254099	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaaacgccagcagacccggGgtcagacccaggatcaccag	12	14	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:30254099G>T	ENST00000361644.2	+	5	795	c.58G>T	c.(58-60)Ggt>Tgt	p.G20C	MAGEB3_ENST00000378986.1_Missense_Mutation_p.G20C	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	20										NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						GCAGACCCGGGGTCAGACCCA	0.517													15	49					2.32078e-09	2.7896e-09	1	1	0	T	30254099	G	T	30254099	3	4	48	1	0	0	0	0	1	0	0	0	9226	1232	43	5	60	5	MAGEB3	23	30254099	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	294195	30254099	125016461	4267	8661										
GK	2710	broad.mit.edu	37	chrX	30709251	30709251	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtctatagtgtggcttgatCtaagaacccagtctaccgtt	10	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:30709251C>A	ENST00000378943.3	+	5	528	c.349C>A	c.(349-351)Cta>Ata	p.L117I	GK_ENST00000378945.3_Missense_Mutation_p.L117I|GK_ENST00000427190.1_5'UTR|GK_ENST00000378946.3_Missense_Mutation_p.L117I	NM_001128127.2	NP_001121599.1	P32189	GLPK_HUMAN	glycerol kinase	117					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)|large_intestine(3)	4						GTGGCTTGATCTAAGAACCCA	0.289													20	45					9.62636e-23	1.34149e-22	1	1	0	A	30709251	C	A	30709251	3	1	48	1	0	0	0	0	1	0	0	0	6461	912	32	2	367	2	GK	23	30709251	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	455152	30709251	124561309	4268	8662										
TAB3	257397	broad.mit.edu	37	chrX	30872825	30872825	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaggactaggtggcataaaGatgtggcccaactgggaagg	16	6	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:30872825G>T	ENST00000378933.1	-	3	1134	c.957C>A	c.(955-957)atC>atA	p.I319I	TAB3_ENST00000378932.2_Silent_p.I319I|TAB3_ENST00000378930.3_Silent_p.I319I|TAB3_ENST00000288422.2_Silent_p.I319I	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	319	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						GTGGCATAAAGATGTGGCCCA	0.493													11	49					3.86212e-05	4.21111e-05	1	1	0	T	30872825	G	T	30872825	2	4	48	1	0	0	0	0	0	0	0	1	15553	932	33	2		2	TAB3	23	30872825	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	163574	30872825	124397735	4269	8663										
FTHL17	53940	broad.mit.edu	37	chrX	31089558	31089558	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccgcccagggtgagcttgtcGaacaggtactcagccaggcc	13	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:31089558G>A	ENST00000359202.3	-	1	612	c.513C>T	c.(511-513)ttC>ttT	p.F171F		NM_031894.2	NP_114100.1	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	171					cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	23						TGAGCTTGTCGAACAGGTACT	0.632													24	50					0	0	1	0	0	A	31089558	G	A	31089558	2	1	48	1	0	0	0	0	0	0	0	1	6117	1049	37	1		1	FTHL17	23	31089558	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	216733	31089558	124181002	4270	8664										
DMD	1756	broad.mit.edu	37	chrX	31947829	31947829	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcatttaattgtttgagaaTtccctggcgcaggggcaact	10	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:31947829T>G	ENST00000357033.4	-	47	7002	c.6796A>C	c.(6796-6798)Att>Ctt	p.I2266L	DMD_ENST00000359836.1_5'UTR|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000474231.1_5'UTR|DMD_ENST00000343523.2_5'UTR|DMD_ENST00000378677.2_Missense_Mutation_p.I2262L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2266					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGTTTGAGAATTCCCTGGCGC	0.418													32	56					0	0	1	0	0	G	31947829	T	G	31947829	3	3	48	1	0	0	0	0	1	0	0	0	4608	1493	52	4	4541	4	DMD	23	31947829	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	858271	31947829	123322731	4271	8665										
DMD	1756	broad.mit.edu	37	chrX	32404483	32404483	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttactctttcatcaagttCtttgggattttccgtctgct	7	9	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:32404483C>A	ENST00000357033.4	-	33	4824	c.4618G>T	c.(4618-4620)Gaa>Taa	p.E1540*	DMD_ENST00000378677.2_Nonsense_Mutation_p.E1536*	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1540	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCATCAAGTTCTTTGGGATTT	0.398													35	67					6.90743e-12	8.65044e-12	1	1	0	A	32404483	C	A	32404483	4	1	48	1	0	0	0	0	0	1	0	0	4608	922	32	2	6775	2	DMD	23	32404483	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	456654	32404483	122866077	4272	8666										
DMD	1756	broad.mit.edu	37	chrX	32827713	32827713	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcaaaccacactattccaGtcaaataggtctggcctaaa	7	11	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:32827713G>A	ENST00000357033.4	-	7	752	c.546C>T	c.(544-546)gaC>gaT	p.D182D	DMD_ENST00000288447.4_Silent_p.D174D|DMD_ENST00000378677.2_Silent_p.D178D	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	182	Actin-binding.|CH 2.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CACTATTCCAGTCAAATAGGT	0.393													24	38					0	0	1	0	0	A	32827713	G	A	32827713	2	1	48	1	0	0	0	0	0	0	0	1	4608	1020	36	3		3	DMD	23	32827713	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	423230	32827713	122442847	4273	8667										
FAM47A	158724	broad.mit.edu	37	chrX	34148674	34148674	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatgtaggatgctcgaatCttgggaggctccgagaattg	13	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:34148674C>A	ENST00000346193.3	-	1	1773	c.1722G>T	c.(1720-1722)aaG>aaT	p.K574N		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	574										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						ATGCTCGAATCTTGGGAGGCT	0.512													17	67					4.7546e-09	5.67505e-09	1	1	0	A	34148674	C	A	34148674	3	1	48	1	0	0	0	0	1	0	0	0	5604	912	32	2	657	2	FAM47A	23	34148674	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1320961	34148674	121121886	4274	8668										
CXorf22	170063	broad.mit.edu	37	chrX	35974224	35974224	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcatcataaaaaatcaatgcGaattacttcctgtgacgtac	6	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:35974224G>T	ENST00000297866.5	+	8	1387	c.1321G>T	c.(1321-1323)Gaa>Taa	p.E441*		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	441								p.E441K(2)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AAATCAATGCGAATTACTTCC	0.358													23	50					5.26018e-13	6.70247e-13	1	1	0	T	35974224	G	T	35974224	4	4	48	1	0	0	0	0	0	1	0	0	4125	1059	37	2	1351	2	CXorf22	23	35974224	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1825550	35974224	119296336	4275	8669										
CXorf22	170063	broad.mit.edu	37	chrX	35984785	35984785	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaagatttgcaatctttgtCggtaaaatctttccatcacg	7	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:35984785C>T	ENST00000297866.5	+	9	1580	c.1514C>T	c.(1513-1515)tCg>tTg	p.S505L		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	505								p.S505L(2)|p.S505W(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						CAATCTTTGTCGGTAAAATCT	0.368													27	44					0	0	1	0	0	T	35984785	C	T	35984785	3	4	48	1	0	0	0	0	1	0	0	0	4125	893	31	1	1548	1	CXorf22	23	35984785	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10561	35984785	119285775	4276	8670										
CXorf22	170063	broad.mit.edu	37	chrX	35988963	35988963	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatttgaaaaacagcaaaaGaaattacatgaaaactatta	4	5	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:35988963G>A	ENST00000297866.5	+	11	1959	c.1893G>A	c.(1891-1893)aaG>aaA	p.K631K		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	631										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AACAGCAAAAGAAATTACATG	0.308													5	16					0	0	1	0	0	A	35988963	G	A	35988963	2	1	48	1	0	0	0	0	0	0	0	1	4125	933	33	3		3	CXorf22	23	35988963	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4178	35988963	119281597	4277	8671										
XK	7504	broad.mit.edu	37	chrX	37586899	37586899	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctccccaggtctcctcatGaccatatccctgttgtccat	5	16	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:37586899G>T	ENST00000378616.3	+	3	722	c.519G>T	c.(517-519)atG>atT	p.M173I	TM4SF2_ENST00000465127.1_Intron	NM_021083.2	NP_066569.1	P51811	XK_HUMAN	X-linked Kx blood group (McLeod syndrome)	173					amino acid transport	integral to membrane	protein binding|transporter activity			breast(1)|endometrium(4)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		all_lung(315;0.175)				GTCTCCTCATGACCATATCCC	0.498													9	34					3.09899e-07	3.54467e-07	1	1	0	T	37586899	G	T	37586899	3	4	48	1	0	0	0	0	1	0	0	0	17490	1290	45	2	529	2	XK	23	37586899	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1597936	37586899	117683661	4278	8672										
SYTL5	94122	broad.mit.edu	37	chrX	37893260	37893260	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagtggaggacaagagaataAggtagtattctttttatttt	10	2	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:37893260A>T	ENST00000357972.5	+	2	664	c.119_splice	c.e2+1	p.R40_splice	SYTL5_ENST00000456733.2_Splice_Site_p.R40_splice|TM4SF2_ENST00000465127.1_Intron|SYTL5_ENST00000297875.2_Splice_Site_p.R40_splice			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	40	RabBD.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						CAAGAGAATAAGGTAGTATTC	0.368													6	19					0	0	1	0	0	T	37893260	A	T	37893260	5	4	48	1	0	0	0	0	0	0	1	0	15542	86	3	4	120	4	SYTL5	23	37893260	Splice_Site	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	306361	37893260	117377300	4279	8673										
CXorf38	159013	broad.mit.edu	37	chrX	40498296	40498296	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgatcaaccacgaagtgatCgcaggagttgatgagactta	11	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:40498296C>T	ENST00000378426.1	-	2	676	c.79G>A	c.(79-81)Gat>Aat	p.D27N	CXorf38_ENST00000378421.1_Missense_Mutation_p.D27N|CXorf38_ENST00000327877.5_Missense_Mutation_p.D146N|CXorf38_ENST00000440784.2_Intron			Q8TB03	CX038_HUMAN	chromosome X open reading frame 38	146										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	12						ACGAAGTGATCGCAGGAGTTG	0.493													18	35					0	0	1	0	0	T	40498296	C	T	40498296	3	4	48	1	0	0	0	0	1	0	0	0	4130	884	31	1	539	1	CXorf38	23	40498296	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2605036	40498296	114772264	4280	8674										
MED14	9282	broad.mit.edu	37	chrX	40586033	40586033	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgccagcattattagcccAtttcactaaagctaataatc	4	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:40586033A>G	ENST00000324817.1	-	3	431	c.313T>C	c.(313-315)Tgg>Cgg	p.W105R		NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	105					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTATTAGCCCATTTCACTAAA	0.323													10	29					0	0	1	0	0	G	40586033	A	G	40586033	3	3	48	1	0	0	0	0	1	0	0	0	9481	217	8	4	4167	4	MED14	23	40586033	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	87737	40586033	114684527	4281	8675										
USP9X	8239	broad.mit.edu	37	chrX	41025176	41025176	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgctcctcaggcaaaacaAatatggaaatgcttagctga	9	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:41025176A>C	ENST00000324545.7	+	16	2670	c.2037A>C	c.(2035-2037)caA>caC	p.Q679H	USP9X_ENST00000378308.2_Missense_Mutation_p.Q679H	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	679					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						AGGCAAAACAAATATGGAAAT	0.368													5	90					0	0	1	0	0	C	41025176	A	C	41025176	3	2	48	1	0	0	0	0	1	0	0	0	17149	11	1	4	2095	4	USP9X	23	41025176	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	439143	41025176	114245384	4282	8676										
USP9X	8239	broad.mit.edu	37	chrX	41043781	41043781	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accagaaataacttcctaccGaatgcagatatggaaactcg	7	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:41043781G>A	ENST00000324545.7	+	23	4044	c.3411G>A	c.(3409-3411)ccG>ccA	p.P1137P	USP9X_ENST00000378308.2_Silent_p.P1137P	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1137					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						ACTTCCTACCGAATGCAGATA	0.453													7	39					0	0	1	0	0	A	41043781	G	A	41043781	2	1	48	1	0	0	0	0	0	0	0	1	17149	1045	37	1		1	USP9X	23	41043781	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	18605	41043781	114226779	4283	8677										
USP9X	8239	broad.mit.edu	37	chrX	41055931	41055931	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacgcttacaatagtaatatTaatgtacccaatgctgaagt	6	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:41055931T>G	ENST00000324545.7	+	28	4806	c.4173T>G	c.(4171-4173)atT>atG	p.I1391M	USP9X_ENST00000378308.2_Missense_Mutation_p.I1391M	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1391					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						ATAGTAATATTAATGTACCCA	0.328													18	19					0	0	1	0	0	G	41055931	T	G	41055931	3	3	48	1	0	0	0	0	1	0	0	0	17149	1742	61	4	4279	4	USP9X	23	41055931	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	12150	41055931	114214629	4284	8678										
USP9X	8239	broad.mit.edu	37	chrX	41057954	41057954	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtgtgaggaatctcaaacaAatagtagattctttgactga	9	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:41057954A>C	ENST00000324545.7	+	30	5187	c.4554A>C	c.(4552-4554)caA>caC	p.Q1518H	USP9X_ENST00000378308.2_Missense_Mutation_p.Q1518H	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1518					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						ATCTCAAACAAATAGTAGATT	0.343													22	26					0	0	1	0	0	C	41057954	A	C	41057954	3	2	48	1	0	0	0	0	1	0	0	0	17149	11	1	4	4668	4	USP9X	23	41057954	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	2023	41057954	114212606	4285	8679										
GPR34	2857	broad.mit.edu	37	chrX	41555424	41555424	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgtctgttgtatagtatggAtgcttgctcttggtggattc	12	5	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:41555424A>G	ENST00000378142.4	+	3	822	c.538A>G	c.(538-540)Atg>Gtg	p.M180V	CASK_ENST00000442742.2_Intron|CASK_ENST00000318588.9_Intron|CASK_ENST00000378163.1_Intron|CASK_ENST00000378154.1_Intron|CASK_ENST00000378158.1_Intron|CASK_ENST00000421587.2_Intron|CASK_ENST00000378166.4_Intron|CASK_ENST00000361962.4_Intron|GPR34_ENST00000378138.5_Missense_Mutation_p.M180V	NM_001097579.1|NM_005300.3	NP_001091048.1|NP_005291.1	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	180						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	14						TATAGTATGGATGCTTGCTCT	0.348													22	55					0	0	1	0	0	G	41555424	A	G	41555424	3	3	48	1	0	0	0	0	1	0	0	0	6728	333	12	4	540	4	GPR34	23	41555424	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	497470	41555424	113715136	4286	8680										
GPR34	2857	broad.mit.edu	37	chrX	41555868	41555868	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcttagatccagtcatgtatTtcctgatgtccagtaacatt	7	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:41555868T>G	ENST00000378142.4	+	3	1266	c.982T>G	c.(982-984)Ttc>Gtc	p.F328V	CASK_ENST00000442742.2_Intron|CASK_ENST00000318588.9_Intron|CASK_ENST00000378163.1_Intron|CASK_ENST00000378154.1_Intron|CASK_ENST00000378158.1_Intron|CASK_ENST00000421587.2_Intron|CASK_ENST00000378166.4_Intron|CASK_ENST00000361962.4_Intron|GPR34_ENST00000378138.5_Missense_Mutation_p.F328V	NM_001097579.1|NM_005300.3	NP_001091048.1|NP_005291.1	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	328						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	14						AGTCATGTATTTCCTGATGTC	0.363													5	39					0	0	1	0	0	G	41555868	T	G	41555868	3	3	48	1	0	0	0	0	1	0	0	0	6728	1841	64	4	984	4	GPR34	23	41555868	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	444	41555868	113714692	4287	8681										
EFHC2	80258	broad.mit.edu	37	chrX	44035549	44035549	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctaacttaccttgacaataaGgattctagaagatcatcact	5	9	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:44035549G>T	ENST00000420999.1	-	13	2114	c.2031C>A	c.(2029-2031)tcC>tcA	p.S677S	EFHC2_ENST00000343571.3_5'UTR	NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	677							calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						TTGACAATAAGGATTCTAGAA	0.373													4	4					2.56e-06	2.86294e-06	1	1	0	T	44035549	G	T	44035549	2	4	48	1	0	0	0	0	0	0	0	1	4973	987	35	5		5	EFHC2	23	44035549	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2479681	44035549	111235011	4288	8682										
CHST7	56548	broad.mit.edu	37	chrX	46433855	46433855	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgcgttcgctcttccgctgCgacttctccgtgctgcggct	11	16	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:46433855C>T	ENST00000276055.3	+	1	637	c.489C>T	c.(487-489)tgC>tgT	p.C163C		NM_019886.2	NP_063939.2	Q9NS84	CHST7_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	163					chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)|endometrium(2)|kidney(1)|lung(2)	8						TCTTCCGCTGCGACTTCTCCG	0.701													18	28					0	0	1	0	0	T	46433855	C	T	46433855	2	4	48	1	0	0	0	0	0	0	0	1	3431	776	27	1		1	CHST7	23	46433855	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2398306	46433855	108836705	4289	8683										
UBA1	7317	broad.mit.edu	37	chrX	47060346	47060346	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagctgcgagtgggtgagttCtgtcacaaccgtggcatcaa	13	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47060346C>T	ENST00000335972.6	+	6	717	c.534C>T	c.(532-534)ttC>ttT	p.F178F	UBA1_ENST00000377351.4_Silent_p.F178F	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	178	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGGGTGAGTTCTGTCACAACC	0.632													6	13					0	0	1	0	0	T	47060346	C	T	47060346	2	4	48	1	0	0	0	0	0	0	0	1	16887	912	32	3		3	UBA1	23	47060346	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	626491	47060346	108210214	4290	8684										
ARAF	369	broad.mit.edu	37	chrX	47424688	47424688	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggatttgtccggaggctccAgacagcatgaggctccctcg	13	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47424688A>G	ENST00000377045.4	+	6	690	c.496A>G	c.(496-498)Aga>Gga	p.R166G	ARAF_ENST00000377039.2_Missense_Mutation_p.R166G|ARAF_ENST00000290277.6_Missense_Mutation_p.R166G	NM_001256196.1|NM_001654.4	NP_001243125.1|NP_001645.1	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene homolog	166					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			biliary_tract(1)|endometrium(4)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	29					Adenosine triphosphate(DB00171)	CGGAGGCTCCAGACAGCATGA	0.582													9	67					0	0	1	0	0	G	47424688	A	G	47424688	3	3	48	1	0	0	0	0	1	0	0	0	834	180	7	4	514	4	ARAF	23	47424688	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	364342	47424688	107845872	4291	8685										
TIMP1	7076	broad.mit.edu	37	chrX	47444652	47444652	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgccgctgacatccggttcGtctacacccccgccatggag	10	16	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47444652G>A	ENST00000456754.2	+	4	325	c.250G>A	c.(250-252)Gtc>Atc	p.V84I	SYN1_ENST00000340666.4_Intron|TIMP1_ENST00000218388.4_Missense_Mutation_p.V84I|SYN1_ENST00000295987.7_Intron|TIMP1_ENST00000377018.2_Silent_p.S7S|TIMP1_ENST00000377017.1_Missense_Mutation_p.V20I			P01033	TIMP1_HUMAN	TIMP metallopeptidase inhibitor 1	84	NTR.				erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(1)|large_intestine(2)	3						CATCCGGTTCGTCTACACCCC	0.562													5	33					0	0	1	0	0	A	47444652	G	A	47444652	3	1	48	1	0	0	0	0	1	0	0	0	15976	1145	40	1	260	1	TIMP1	23	47444652	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	19964	47444652	107825908	4292	8686										
UXT	8409	broad.mit.edu	37	chrX	47516992	47516992	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccactgtgtcaacgaagaagTtacagcccaaatccacctgc	7	14	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47516992T>G	ENST00000335890.2	-	3	416	c.263A>C	c.(262-264)aAc>aCc	p.N88T	UXT_ENST00000333119.3_Missense_Mutation_p.N76T	NM_153477.2	NP_705582.1	Q9UBK9	UXT_HUMAN	ubiquitously-expressed, prefoldin-like chaperone	76					centrosome organization|mitochondrion transport along microtubule|protein folding	centrosome|nucleus|prefoldin complex	beta-tubulin binding|microtubule binding|unfolded protein binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(1)	6						AACGAAGAAGTTACAGCCCAA	0.498													11	21					0	0	1	0	0	G	47516992	T	G	47516992	3	3	48	1	0	0	0	0	1	0	0	0	17169	1725	60	4	262	4	UXT	23	47516992	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	72340	47516992	107753568	4293	8687										
UXT	8409	broad.mit.edu	37	chrX	47517203	47517203	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagtcgctcaatgacatttCtcagttgaaggtatttggcc	11	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47517203C>A	ENST00000335890.2	-	2	347	c.194G>T	c.(193-195)aGa>aTa	p.R65I	UXT_ENST00000333119.3_Missense_Mutation_p.R53I	NM_153477.2	NP_705582.1	Q9UBK9	UXT_HUMAN	ubiquitously-expressed, prefoldin-like chaperone	53					centrosome organization|mitochondrion transport along microtubule|protein folding	centrosome|nucleus|prefoldin complex	beta-tubulin binding|microtubule binding|unfolded protein binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(1)	6						AATGACATTTCTCAGTTGAAG	0.488													6	36					0.00116845	0.00122532	1	1	0	A	47517203	C	A	47517203	3	1	48	1	0	0	0	0	1	0	0	0	17169	913	32	2	335	2	UXT	23	47517203	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	211	47517203	107753357	4294	8688										
ZNF81	347344	broad.mit.edu	37	chrX	47775478	47775478	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgcagtgactgtgggaaatCtttcccttctaagtcacaac	8	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47775478C>A	ENST00000376954.1	+	6	1801	c.1433C>A	c.(1432-1434)tCt>tAt	p.S478Y	ZNF81_ENST00000338637.7_Missense_Mutation_p.S478Y			P51508	ZNF81_HUMAN	zinc finger protein 81	478						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				TGTGGGAAATCTTTCCCTTCT	0.438													22	45					1.87028e-06	2.10206e-06	1	1	0	A	47775478	C	A	47775478	3	1	48	1	0	0	0	0	1	0	0	0	18221	913	32	2	1447	2	ZNF81	23	47775478	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	258275	47775478	107495082	4295	8689										
ZNF81	347344	broad.mit.edu	37	chrX	47775514	47775514	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaactccagatgcataagaGaattcatacaggagagaaac	8	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47775514G>T	ENST00000376954.1	+	6	1837	c.1469G>T	c.(1468-1470)aGa>aTa	p.R490I	ZNF81_ENST00000338637.7_Missense_Mutation_p.R490I			P51508	ZNF81_HUMAN	zinc finger protein 81	490						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R490I(1)		breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				ATGCATAAGAGAATTCATACA	0.408													24	43					3.83957e-06	4.27438e-06	1	1	0	T	47775514	G	T	47775514	3	4	48	1	0	0	0	0	1	0	0	0	18221	942	33	2	1483	2	ZNF81	23	47775514	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	36	47775514	107495046	4296	8690										
ZNF630	57232	broad.mit.edu	37	chrX	47918899	47918899	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtttctccccagtatgaatcCtctgatgcacaatgaggtgt	9	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47918899C>A	ENST00000276054.4	-	5	1494	c.560G>T	c.(559-561)aGg>aTg	p.R187M	ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000442455.3_Missense_Mutation_p.R297M|ZNF630_ENST00000409324.3_Missense_Mutation_p.R311M			Q2M218	ZN630_HUMAN	zinc finger protein 630	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						AGTATGAATCCTCTGATGCAC	0.418													23	12					3.62473e-10	4.42315e-10	1	1	0	A	47918899	C	A	47918899	3	1	48	1	0	0	0	0	1	0	0	0	18110	681	24	5	1045	5	ZNF630	23	47918899	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	143385	47918899	107351661	4297	8691										
ZNF630	57232	broad.mit.edu	37	chrX	47919053	47919053	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actacaaacattgggtttctCtctggcttgaaatttcttat	6	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:47919053C>T	ENST00000276054.4	-	5	1340	c.406G>A	c.(406-408)Gag>Aag	p.E136K	ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000442455.3_Missense_Mutation_p.E246K|ZNF630_ENST00000409324.3_Missense_Mutation_p.E260K			Q2M218	ZN630_HUMAN	zinc finger protein 630	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						TTGGGTTTCTCTCTGGCTTGA	0.378													32	14					0	0	1	0	0	T	47919053	C	T	47919053	3	4	48	1	0	0	0	0	1	0	0	0	18110	922	32	3	1199	3	ZNF630	23	47919053	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	154	47919053	107351507	4298	8692										
SSX5	6758	broad.mit.edu	37	chrX	48054555	48054555	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttccacggtcacagacttgtCtccagggatgctaggtgatg	12	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48054555C>T	ENST00000311798.1	-	3	132	c.80G>A	c.(79-81)aGa>aAa	p.R27K	SSX5_ENST00000347757.1_Intron|SSX5_ENST00000376923.1_Intron	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	23	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						ACAGACTTGTCTCCAGGGATG	0.557													15	74					0	0	1	0	0	T	48054555	C	T	48054555	3	4	48	1	0	0	0	0	1	0	0	0	15263	913	32	3	633	3	SSX5	23	48054555	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	135502	48054555	107216005	4299	8693										
SSX1	6756	broad.mit.edu	37	chrX	48125776	48125776	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgcgtgagagaaagcagcTggtgatttatgaagagatca	13	5	1	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48125776T>G	ENST00000376919.3	+	7	657	c.521T>G	c.(520-522)cTg>cGg	p.L174R		NM_001278691.1|NM_005635.2	NP_001265620.1|NP_005626.1	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)|SS18L1/SSX1(2)	endometrium(2)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9						AGAAAGCAGCTGGTGATTTAT	0.502			T	SS18	synovial sarcoma								11	363					0	0	1	0	0	G	48125776	T	G	48125776	3	3	48	1	0	0	0	0	1	0	0	0	15258	1580	55	4	543	4	SSX1	23	48125776	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	71221	48125776	107144784	4300	8694										
WAS	7454	broad.mit.edu	37	chrX	48542671	48542671	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acccctgctttcctctcccaGacgctggccactgcagttgt	8	17	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48542671G>T	ENST00000376701.4	+	2	207		c.e2-1		WAS_ENST00000483750.1_Splice_Site	NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome						blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				TCCTCTCCCAGACGCTGGCCA	0.602			"Mis, N, F, S"			lymphoma							26	43					2.12542e-12	2.68024e-12	1	1	0	T	48542671	G	T	48542671	5	4	48	1	0	0	0	0	0	0	1	0	17310	956	33	2	138	2	WAS	23	48542671	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	416895	48542671	106727889	4301	8695										
WAS	7454	broad.mit.edu	37	chrX	48542779	48542779	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcgtgaaggataacccccaGaagtcctacttcatccgcct	7	14	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48542779G>T	ENST00000376701.4	+	2	315	c.240G>T	c.(238-240)caG>caT	p.Q80H	WAS_ENST00000483750.1_3'UTR	NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	80	WH1.				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				ATAACCCCCAGAAGTCCTACT	0.592			"Mis, N, F, S"			lymphoma							21	26					1.96292e-10	2.40731e-10	1	1	0	T	48542779	G	T	48542779	3	4	48	1	0	0	0	0	1	0	0	0	17310	933	33	2	246	2	WAS	23	48542779	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	108	48542779	106727781	4302	8696										
WAS	7454	broad.mit.edu	37	chrX	48549533	48549533	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggctggcgatgaagatgaaGatgatgaatgggatgactga	16	3	0	8			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48549533G>T	ENST00000376701.4	+	12	1564	c.1489G>T	c.(1489-1491)Gat>Tat	p.D497Y		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	497	Asp/Glu-rich (acidic).				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				TGAAGATGAAGATGATGAATG	0.597			"Mis, N, F, S"			lymphoma							23	35					6.36457e-07	7.23721e-07	1	1	0	T	48549533	G	T	48549533	3	4	48	1	0	0	0	0	1	0	0	0	17310	942	33	2	1535	2	WAS	23	48549533	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6754	48549533	106721027	4303	8697										
GLOD5	392465	broad.mit.edu	37	chrX	48624299	48624299	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atccgtagacttgaccacatCgtgatgacggtgaagagcat	11	9	0	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48624299C>T	ENST00000303227.6	+	2	164	c.123C>T	c.(121-123)atC>atT	p.I41I	GLOD5_ENST00000470676.1_3'UTR	NM_001080489.2	NP_001073958.2			glyoxalase domain containing 5											endometrium(1)|lung(2)	3						TTGACCACATCGTGATGACGG	0.463													11	9					0	0	1	0	0	T	48624299	C	T	48624299	2	4	48	1	0	0	0	0	0	0	0	1	6492	874	31	1		1	GLOD5	23	48624299	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	74766	48624299	106646261	4304	8698										
HDAC6	10013	broad.mit.edu	37	chrX	48682971	48682971	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggctctcctagatgtgaaGaacatcgcccaccagaacaa	8	13	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48682971G>T	ENST00000334136.5	+	29	3775	c.3597G>T	c.(3595-3597)aaG>aaT	p.K1199N	HDAC6_ENST00000376619.2_Missense_Mutation_p.K1199N|HDAC6_ENST00000444343.2_Missense_Mutation_p.K1213N			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1199					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	TAGATGTGAAGAACATCGCCC	0.592													16	24					7.07596e-05	7.68259e-05	1	1	0	T	48682971	G	T	48682971	3	4	48	1	0	0	0	0	1	0	0	0	7051	933	33	2	3707	2	HDAC6	23	48682971	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58672	48682971	106587589	4305	8699										
GRIPAP1	56850	broad.mit.edu	37	chrX	48839393	48839393	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggcatcaccaactcacctCggcttccttcaagcgccgtt	7	17	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48839393C>T	ENST00000376423.4	-	16	1470	c.1438G>A	c.(1438-1440)Gag>Aag	p.E480K	GRIPAP1_ENST00000376425.3_Missense_Mutation_p.E502K|GRIPAP1_ENST00000376441.1_Missense_Mutation_p.E533K|GRIPAP1_ENST00000376444.3_Missense_Mutation_p.E488K|GRIPAP1_ENST00000473581.1_5'UTR	NM_207672.1	NP_997555.1	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1	533						early endosome				breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(2)	10						CAACTCACCTCGGCTTCCTTC	0.557													13	35					0	0	1	0	0	T	48839393	C	T	48839393	3	4	48	1	0	0	0	0	1	0	0	0	6829	893	31	1	1022	1	GRIPAP1	23	48839393	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	156422	48839393	106431167	4306	8700										
TFE3	7030	broad.mit.edu	37	chrX	48891263	48891263	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggttgtgattgtctttcttCtgccgttccttcaaaagggc	10	9	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:48891263C>A	ENST00000315869.7	-	7	1297	c.1038G>T	c.(1036-1038)caG>caT	p.Q346H	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	346					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						TGTCTTTCTTCTGCCGTTCCT	0.557			T	"SFPQ, ASPSCR1, PRCC, NONO, CLTC"	"papillary renal, alveolar soft part sarcoma, renal"								10	19					0.00621372	0.0064192	1	1	0	A	48891263	C	A	48891263	3	1	48	1	0	0	0	0	1	0	0	0	15859	912	32	2	705	2	TFE3	23	48891263	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	51870	48891263	106379297	4307	8701										
PLP2	5355	broad.mit.edu	37	chrX	49029577	49029577	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctgctattttctttgttgtCtacatgtgtgacctgcacac	8	10	2	1	rs149039155		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:49029577C>T	ENST00000376327.5	+	2	273	c.198C>T	c.(196-198)gtC>gtT	p.V66V	PLP2_ENST00000376322.3_Silent_p.V66V	NM_002668.2	NP_002659.1	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic epithelium-enriched)	66	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity			endometrium(3)|large_intestine(1)|lung(6)|urinary_tract(3)	13						TCTTTGTTGTCTACATGTGTG	0.512													15	34					0	0	1	0	0	T	49029577	C	T	49029577	2	4	48	1	0	0	0	0	0	0	0	1	12152	900	32	3		3	PLP2	23	49029577	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	138314	49029577	106240983	4308	8702										
PRICKLE3	4007	broad.mit.edu	37	chrX	49032046	49032046	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccacgatgcagttcttgtcTcgggcctgacgaggcatccc	12	14	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:49032046T>A	ENST00000376317.3	-	9	1918	c.1824A>T	c.(1822-1824)cgA>cgT	p.R608R	PRICKLE3_ENST00000536904.1_Silent_p.R527R|PRICKLE3_ENST00000538114.1_Silent_p.R432R|PRICKLE3_ENST00000540849.1_Silent_p.R540R	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	608							protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						AGTTCTTGTCTCGGGCCTGAC	0.622													21	36					0	0	1	0	0	A	49032046	T	A	49032046	2	1	48	1	0	0	0	0	0	0	0	1	12539	1538	54	4		4	PRICKLE3	23	49032046	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2469	49032046	106238514	4309	8703										
CACNA1F	778	broad.mit.edu	37	chrX	49061728	49061728	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actggcagcattgtccatctCatccagcgtcaggcgacacg	10	14	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:49061728C>A	ENST00000376265.2	-	48	5864	c.5803G>T	c.(5803-5805)Gag>Tag	p.E1935*	CACNA1F_ENST00000376251.1_Nonsense_Mutation_p.E1870*|CACNA1F_ENST00000323022.5_Nonsense_Mutation_p.E1924*	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1935					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	TTGTCCATCTCATCCAGCGTC	0.592													14	30					4.93089e-13	6.29573e-13	1	1	0	A	49061728	C	A	49061728	4	1	48	1	0	0	0	0	0	1	0	0	2561	835	29	2	134	2	CACNA1F	23	49061728	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29682	49061728	106208832	4310	8704										
CACNA1F	778	broad.mit.edu	37	chrX	49084859	49084859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggttcagcgtgcacgcacGccctgatcccgaagacgcac	11	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:49084859G>A	ENST00000376265.2	-	7	929	c.868C>T	c.(868-870)Cgt>Tgt	p.R290C	CACNA1F_ENST00000376251.1_Missense_Mutation_p.R225C|CACNA1F_ENST00000323022.5_Missense_Mutation_p.R290C	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	290					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GTGCACGCACGCCCTGATCCC	0.617													15	18					0	0	1	0	0	A	49084859	G	A	49084859	3	1	48	1	0	0	0	0	1	0	0	0	2561	1087	38	1	5233	1	CACNA1F	23	49084859	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	23131	49084859	106185701	4311	8705										
AKAP4	8852	broad.mit.edu	37	chrX	49958138	49958138	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccactggttgaacagatttCtcttgacagctgagacaaag	9	9	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:49958138C>A	ENST00000376056.2	-	5	1349	c.1199G>T	c.(1198-1200)aGa>aTa	p.R400I	AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000376064.3_Missense_Mutation_p.R400I|AKAP4_ENST00000358526.2_Missense_Mutation_p.R409I|AKAP4_ENST00000481402.1_5'UTR			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	409					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GAACAGATTTCTCTTGACAGC	0.448													18	49					6.49762e-13	8.24929e-13	1	1	0	A	49958138	C	A	49958138	3	1	48	1	0	0	0	0	1	0	0	0	450	913	32	2	1346	2	AKAP4	23	49958138	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	873279	49958138	105312422	4312	8706										
CCNB3	85417	broad.mit.edu	37	chrX	50053473	50053473	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaagaagcagttggctttGaatgagaccatcaatgaaga	11	6	1	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:50053473G>T	ENST00000376042.1	+	6	2602	c.2304G>T	c.(2302-2304)ttG>ttT	p.L768F	CCNB3_ENST00000276014.7_Missense_Mutation_p.L768F|CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	768					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					AGTTGGCTTTGAATGAGACCA	0.458													6	15					3.59834e-05	3.93264e-05	1	1	0	T	50053473	G	T	50053473	3	4	48	1	0	0	0	0	1	0	0	0	2936	1281	45	2	2318	2	CCNB3	23	50053473	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	95335	50053473	105217087	4313	8707										
DGKK	139189	broad.mit.edu	37	chrX	50129446	50129446	+	RNA	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttgcacttggctatgtggtCtatttgaggaatgaagggct	13	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:50129446C>A	ENST00000376025.2	-	0	2316							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					GCTATGTGGTCTATTTGAGGA	0.473													19	38					1.00905e-13	1.29777e-13	1	1	0	A	50129446	C	A	50129446	1	1	48	0	1	0	0	0	0	0	0	0	4500	913	32	2		2	DGKK	23	50129446	RNA	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	75973	50129446	105141114	4314	8708										
DGKK	139189	broad.mit.edu	37	chrX	50167262	50167262	+	RNA	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaccgcgggatggtgtgcaAagtagagcttctgtccttga	13	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:50167262A>C	ENST00000376025.2	-	0	799							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					ATGGTGTGCAAAGTAGAGCTT	0.403													6	44					0	0	1	0	0	C	50167262	A	C	50167262	1	2	48	0	1	0	0	0	0	0	0	0	4500	14	1	4		4	DGKK	23	50167262	RNA	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	37816	50167262	105103298	4315	8709										
SHROOM4	57477	broad.mit.edu	37	chrX	50339755	50339755	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catttgagttgctcttccccGagcttgatcttctcctccag	7	14	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:50339755G>A	ENST00000376020.2	-	9	4447	c.4422C>T	c.(4420-4422)ctC>ctT	p.L1474L	SHROOM4_ENST00000460112.3_Silent_p.L1358L|SHROOM4_ENST00000289292.7_Silent_p.L1474L	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1474	ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					GCTCTTCCCCGAGCTTGATCT	0.522													14	36					0	0	1	0	0	A	50339755	G	A	50339755	2	1	48	1	0	0	0	0	0	0	0	1	14350	1045	37	1		1	SHROOM4	23	50339755	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	172493	50339755	104930805	4316	8710										
SHROOM4	57477	broad.mit.edu	37	chrX	50377889	50377889	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatgtggaggtctgccaaaaGaagccttagctagctctgca	12	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:50377889G>T	ENST00000376020.2	-	4	1209	c.1184C>A	c.(1183-1185)tCt>tAt	p.S395Y	SHROOM4_ENST00000460112.3_Missense_Mutation_p.S279Y|SHROOM4_ENST00000289292.7_Missense_Mutation_p.S395Y	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	395					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					TCTGCCAAAAGAAGCCTTAGC	0.552													10	15					0.000442599	0.00046913	1	1	0	T	50377889	G	T	50377889	3	4	48	1	0	0	0	0	1	0	0	0	14350	942	33	2	3321	2	SHROOM4	23	50377889	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	38134	50377889	104892671	4317	8711										
SSX7	280658	broad.mit.edu	37	chrX	52681946	52681946	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtcatggcctcatactttCtcttcatatacacatagctg	5	11	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:52681946C>A	ENST00000298181.5	-	3	316	c.158G>T	c.(157-159)aGa>aTa	p.R53I		NM_173358.2	NP_775494.1	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	53	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|skin(1)	16	Ovarian(276;0.236)					CTCATACTTTCTCTTCATATA	0.393													36	66					6.97489e-18	9.40748e-18	1	1	0	A	52681946	C	A	52681946	3	1	48	1	0	0	0	0	1	0	0	0	15264	913	32	2	428	2	SSX7	23	52681946	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2304057	52681946	102588614	4318	8712										
KDM5C	8242	broad.mit.edu	37	chrX	53254069	53254069	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatcgtcggaccccggctcCatggtgggcccgaggtctgg	15	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:53254069C>T	ENST00000452825.3	-	1	535	c.3G>A	c.(1-3)atG>atA	p.M1I	KDM5C_ENST00000375401.3_Start_Codon_SNP_p.M1I|KDM5C_ENST00000375379.3_Start_Codon_SNP_p.M1I|KDM5C_ENST00000375383.3_Start_Codon_SNP_p.M1I|KDM5C_ENST00000404049.3_Start_Codon_SNP_p.M1I	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	0					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						ACCCCGGCTCCATGGTGGGCC	0.652			"N, F, S"		clear cell renal carcinoma								17	15					0	0	1	0	0	T	53254069	C	T	53254069	1	4	48	1	0	0	0	0	0	0	0	0	8177	594	21	3		3	KDM5C	23	53254069	Translation_Start_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	572123	53254069	102016491	4319	8713										
HUWE1	10075	broad.mit.edu	37	chrX	53562435	53562435	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cccattgggtttgaggtcacGaacttcacaaactccaaact	7	12	2	1	rs121918527		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:53562435G>A	ENST00000342160.3	-	80	13016	c.12559C>T	c.(12559-12561)Cgt>Tgt	p.R4187C	HUWE1_ENST00000262854.6_Missense_Mutation_p.R4187C			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4187	HECT.		R -> C (in MRXS-Turner).		base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TTGAGGTCACGAACTTCACAA	0.438													12	25					0	0	1	0	0	A	53562435	G	A	53562435	3	1	48	1	0	0	0	0	1	0	0	0	7504	1058	37	1	581	1	HUWE1	23	53562435	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	308366	53562435	101708125	4320	8714										
HUWE1	10075	broad.mit.edu	37	chrX	53574798	53574798	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggcagtggtggtggtggtaGatgtggttgaggtggcagtg	22	3	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:53574798G>T	ENST00000342160.3	-	67	10929	c.10472C>A	c.(10471-10473)tCt>tAt	p.S3491Y	HUWE1_ENST00000262854.6_Missense_Mutation_p.S3491Y|HUWE1_ENST00000474288.1_5'UTR			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3491	Thr-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ggtggtggtagatgtggttga	0.587													10	22					0.00621372	0.0064192	1	1	0	T	53574798	G	T	53574798	3	4	48	1	0	0	0	0	1	0	0	0	7504	942	33	2	2720	2	HUWE1	23	53574798	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	12363	53574798	101695762	4321	8715										
WNK3	65267	broad.mit.edu	37	chrX	54277993	54277993	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttggagtccacagtaataGaatcaactccagtggctctt	9	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:54277993G>T	ENST00000354646.2	-	14	2933	c.2495C>A	c.(2494-2496)tCt>tAt	p.S832Y	WNK3_ENST00000375159.2_Missense_Mutation_p.S832Y|WNK3_ENST00000375169.3_Missense_Mutation_p.S832Y	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	832					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						CACAGTAATAGAATCAACTCC	0.378													11	21					3.07112e-06	3.42433e-06	1	1	0	T	54277993	G	T	54277993	3	4	48	1	0	0	0	0	1	0	0	0	17438	942	33	2	2951	2	WNK3	23	54277993	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	703195	54277993	100992567	4322	8716										
TRO	7216	broad.mit.edu	37	chrX	54953058	54953058	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagttggggctgcgccctgGgtatgactgggctctctcag	15	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:54953058G>T	ENST00000173898.7	+	9	1812	c.1700_splice	c.e9+1	p.G567_splice	TRO_ENST00000319167.8_Splice_Site_p.G567_splice|TRO_ENST00000420798.2_Splice_Site_p.G98_splice|TRO_ENST00000375022.4_Splice_Site_p.G567_splice|TRO_ENST00000399736.1_Splice_Site_p.G170_splice|TRO_ENST00000375041.2_Splice_Site_p.G170_splice	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	567	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						CTGCGCCCTGGGTATGACTGG	0.577													46	104					1.15181e-12	1.45902e-12	1	1	0	T	54953058	G	T	54953058	5	4	48	1	0	0	0	0	0	0	1	0	16634	1246	43	5	1730	5	TRO	23	54953058	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	675065	54953058	100317502	4323	8717										
PFKFB1	5207	broad.mit.edu	37	chrX	54978379	54978379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccagagtcacctccgatgcGgcctctgatgttgagttcac	11	13	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:54978379G>A	ENST00000375006.3	-	8	875	c.805C>T	c.(805-807)Cgc>Tgc	p.R269C	PFKFB1_ENST00000374992.2_Intron|PFKFB1_ENST00000545676.1_Missense_Mutation_p.R204C	NM_002625.2	NP_002616.2	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	269	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)	24						CCTCCGATGCGGCCTCTGATG	0.587													8	19					0	0	1	0	0	A	54978379	G	A	54978379	3	1	48	1	0	0	0	0	1	0	0	0	11807	1116	39	1	638	1	PFKFB1	23	54978379	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	25321	54978379	100292181	4324	8718										
ALAS2	212	broad.mit.edu	37	chrX	55042056	55042056	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttatgcataattccatcacGctccccaatcccagcgcccc	4	19	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:55042056G>A	ENST00000330807.5	-	8	1260	c.1123C>T	c.(1123-1125)Cgt>Tgt	p.R375C	ALAS2_ENST00000396198.3_Missense_Mutation_p.R362C|ALAS2_ENST00000335854.4_Missense_Mutation_p.R338C|ALAS2_ENST00000498636.1_5'UTR	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	375					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups	p.R375C(1)|p.R362C(1)		central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	ATTCCATCACGCTCCCCAATC	0.522													34	41					0	0	1	0	0	A	55042056	G	A	55042056	3	1	48	1	0	0	0	0	1	0	0	0	482	1087	38	1	656	1	ALAS2	23	55042056	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	63677	55042056	100228504	4325	8719										
PAGE2B	389860	broad.mit.edu	37	chrX	55102524	55102524	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcctcagaaagaggaaatgAccaagagtcttcccagccag	9	11	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:55102524A>G	ENST00000374971.1	+	2	102	c.50A>G	c.(49-51)gAc>gGc	p.D17G	PAGE2B_ENST00000374974.3_Missense_Mutation_p.D17G	NM_001015038.1	NP_001015038.1	Q5JRK9	GGEE3_HUMAN	P antigen family, member 2B	17										lung(3)	3						AGAGGAAATGACCAAGAGTCT	0.343													14	33					0	0	1	0	0	G	55102524	A	G	55102524	3	3	48	1	0	0	0	0	1	0	0	0	11437	275	10	4	52	4	PAGE2B	23	55102524	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	60468	55102524	100168036	4326	8720										
MAGEH1	28986	broad.mit.edu	37	chrX	55479290	55479290	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtccggtggagtatgagttCttctgggggccccgagcaca	15	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:55479290C>A	ENST00000342972.1	+	1	753	c.483C>A	c.(481-483)ttC>ttA	p.F161L		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	161	MAGE.				apoptosis					central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						AGTATGAGTTCTTCTGGGGGC	0.502													43	80					6.2361e-21	8.5756e-21	1	1	0	A	55479290	C	A	55479290	3	1	48	1	0	0	0	0	1	0	0	0	9237	912	32	2	485	2	MAGEH1	23	55479290	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	376766	55479290	99791270	4327	8721										
FAAH2	158584	broad.mit.edu	37	chrX	57407418	57407418	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aacatgatggaggctcatttTtaatgtccaaagtggaccaa	9	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:57407418T>G	ENST00000374900.4	+	7	1072	c.952T>G	c.(952-954)Tta>Gta	p.L318V		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	318						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						AGGCTCATTTTTAATGTCCAA	0.294										HNSCC(52;0.14)			34	47					0	0	1	0	0	G	57407418	T	G	57407418	3	3	48	1	0	0	0	0	1	0	0	0	5385	1838	64	4	978	4	FAAH2	23	57407418	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1928128	57407418	97863142	4328	8722										
ZXDA	7789	broad.mit.edu	37	chrX	57935107	57935107	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttcactgctgggtgtaagaGaatttgctgcttctagctga	12	7	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:57935107G>T	ENST00000358697.4	-	1	1960	c.1748C>A	c.(1747-1749)tCt>tAt	p.S583Y		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	583	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						GGGTGTAAGAGAATTTGCTGC	0.453													46	98					2.24722e-20	3.07898e-20	1	1	0	T	57935107	G	T	57935107	3	4	48	1	0	0	0	0	1	0	0	0	18289	942	33	2	655	2	ZXDA	23	57935107	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	527689	57935107	97335453	4329	8723										
ARHGEF9	23229	broad.mit.edu	37	chrX	62893985	62893985	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctctaaacgtcgcttgcgtTcgttgatctgctgagtcaca	9	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:62893985T>G	ENST00000253401.6	-	6	1657	c.857A>C	c.(856-858)gAa>gCa	p.E286A	ARHGEF9_ENST00000437457.2_Missense_Mutation_p.E233A|ARHGEF9_ENST00000374872.1_Missense_Mutation_p.E265A|ARHGEF9_ENST00000374870.4_Missense_Mutation_p.E184A|ARHGEF9_ENST00000433323.2_Missense_Mutation_p.E57A|ARHGEF9_ENST00000495564.1_5'UTR|ARHGEF9_ENST00000374878.1_Missense_Mutation_p.E284A	NM_015185.2	NP_056000.1	O43307	ARHG9_HUMAN	Cdc42 guanine nucleotide exchange factor (GEF) 9	286	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|skin(1)	35						TCGCTTGCGTTCGTTGATCTG	0.458													9	58					0	0	1	0	0	G	62893985	T	G	62893985	3	3	48	1	0	0	0	0	1	0	0	0	909	1783	62	4	713	4	ARHGEF9	23	62893985	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	4958878	62893985	92376575	4330	8724										
MTMR8	55613	broad.mit.edu	37	chrX	63574754	63574754	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatcagtttccatccacttTccctcatctcttttgaggat	4	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:63574754T>G	ENST00000374852.3	-	4	438	c.371A>C	c.(370-372)gAa>gCa	p.E124A	MTMR8_ENST00000453546.1_Missense_Mutation_p.E124A	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	124						nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						CCATCCACTTTCCCTCATCTC	0.393													13	28					0	0	1	0	0	G	63574754	T	G	63574754	3	3	48	1	0	0	0	0	1	0	0	0	9996	1783	62	4	1787	4	MTMR8	23	63574754	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	680769	63574754	91695806	4331	8725										
LAS1L	81887	broad.mit.edu	37	chrX	64743516	64743516	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccggggccagtcaagggaggCggagcagttgaacagcctcc	16	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:64743516C>T	ENST00000374811.3	-	11	1412	c.1372G>A	c.(1372-1374)Gcc>Acc	p.A458T	LAS1L_ENST00000374807.5_Missense_Mutation_p.A441T|LAS1L_ENST00000374804.5_Missense_Mutation_p.A399T|LAS1L_ENST00000312391.8_3'UTR	NM_031206.4	NP_112483.1	Q9Y4W2	LAS1L_HUMAN	LAS1-like (S. cerevisiae)	458						MLL1 complex|nucleolus	protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	33						TCAAGGGAGGCGGAGCAGTTG	0.577													6	11					0	0	1	0	0	T	64743516	C	T	64743516	3	4	48	1	0	0	0	0	1	0	0	0	8674	768	27	1	848	1	LAS1L	23	64743516	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1168762	64743516	90527044	4332	8726										
LAS1L	81887	broad.mit.edu	37	chrX	64743963	64743963	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgttggccacgatcagttCaacggtccatctgaggatgt	13	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:64743963C>A	ENST00000374811.3	-	10	1313	c.1273G>T	c.(1273-1275)Gaa>Taa	p.E425*	LAS1L_ENST00000374807.5_Nonsense_Mutation_p.E408*|LAS1L_ENST00000374804.5_Nonsense_Mutation_p.E366*|LAS1L_ENST00000312391.8_3'UTR	NM_031206.4	NP_112483.1	Q9Y4W2	LAS1L_HUMAN	LAS1-like (S. cerevisiae)	425						MLL1 complex|nucleolus	protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	33						ACGATCAGTTCAACGGTCCAT	0.597													10	21					6.42651e-13	8.16824e-13	1	1	0	A	64743963	C	A	64743963	4	1	48	1	0	0	0	0	0	1	0	0	8674	835	29	2	951	2	LAS1L	23	64743963	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	447	64743963	90526597	4333	8727										
LAS1L	81887	broad.mit.edu	37	chrX	64751318	64751318	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatccaatccggaatatttaCctgattacaggggagggtgt	11	7	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:64751318C>T	ENST00000374811.3	-	4	473	c.432_splice	c.e4-1	p.V145_splice	LAS1L_ENST00000374807.5_Splice_Site_p.V145_splice|LAS1L_ENST00000374804.5_Splice_Site_p.V103_splice|LAS1L_ENST00000312391.8_Splice_Site_p.V145_splice	NM_031206.4	NP_112483.1	Q9Y4W2	LAS1L_HUMAN	LAS1-like (S. cerevisiae)	145						MLL1 complex|nucleolus	protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	33						GGAATATTTACCTGATTACAG	0.443													9	96					0	0	1	0	0	T	64751318	C	T	64751318	5	4	48	1	0	0	0	0	0	0	1	0	8674	521	18	3	1815	3	LAS1L	23	64751318	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	7355	64751318	90519242	4334	8728										
HEPH	9843	broad.mit.edu	37	chrX	65418735	65418735	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcagaaaggggtggataaaGaattctttcttctcttcact	9	7	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:65418735G>T	ENST00000519389.1	+	11	2070	c.1891G>T	c.(1891-1893)Gaa>Taa	p.E631*	HEPH_ENST00000374727.3_Nonsense_Mutation_p.E580*|HEPH_ENST00000336279.5_Nonsense_Mutation_p.E310*|HEPH_ENST00000441993.2_Nonsense_Mutation_p.E580*|HEPH_ENST00000343002.2_Nonsense_Mutation_p.E577*|HEPH_ENST00000419594.1_Intron			Q9BQS7	HEPH_HUMAN	hephaestin	577	Plastocyanin-like 4.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GGTGGATAAAGAATTCTTTCT	0.438													5	92					0.00116845	0.00122532	1	1	0	T	65418735	G	T	65418735	4	4	48	1	0	0	0	0	0	1	0	0	7094	943	33	2	1933	2	HEPH	23	65418735	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	667417	65418735	89851825	4335	8729										
OPHN1	4983	broad.mit.edu	37	chrX	67333047	67333047	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagagaccagctctttgtGaagtctataggtcatgacag	11	8	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:67333047G>T	ENST00000355520.5	-	17	2037	c.1396C>A	c.(1396-1398)Cac>Aac	p.H466N	OPHN1_ENST00000540071.1_Missense_Mutation_p.H466N	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	466	Rho-GAP.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						AGCTCTTTGTGAAGTCTATAG	0.363													7	22					3.09899e-07	3.54467e-07	1	1	0	T	67333047	G	T	67333047	3	4	48	1	0	0	0	0	1	0	0	0	10922	1290	45	2	1044	2	OPHN1	23	67333047	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1914312	67333047	87937513	4336	8730										
OPHN1	4983	broad.mit.edu	37	chrX	67426472	67426472	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcagtgttttggtctctttCtcatactggcaatagtattt	8	7	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:67426472C>A	ENST00000355520.5	-	10	1517	c.876G>T	c.(874-876)gaG>gaT	p.E292D	OPHN1_ENST00000540071.1_Missense_Mutation_p.E292D	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	292	PH.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						TGGTCTCTTTCTCATACTGGC	0.413													20	53					2.39187e-15	3.14903e-15	1	1	0	A	67426472	C	A	67426472	3	1	48	1	0	0	0	0	1	0	0	0	10922	912	32	2	1592	2	OPHN1	23	67426472	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	93425	67426472	87844088	4337	8731										
STARD8	9754	broad.mit.edu	37	chrX	67943867	67943867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaacaacctgtgccagagtCgggtgtgcgagccctcatgc	14	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:67943867C>T	ENST00000252336.6	+	13	3230	c.2858C>T	c.(2857-2859)tCg>tTg	p.S953L	STARD8_ENST00000374597.3_Missense_Mutation_p.S953L|STARD8_ENST00000374599.3_Missense_Mutation_p.S1033L	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	953	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						GTGCCAGAGTCGGGTGTGCGA	0.617													22	39					0	0	1	0	0	T	67943867	C	T	67943867	3	4	48	1	0	0	0	0	1	0	0	0	15318	893	31	1	3152	1	STARD8	23	67943867	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	517395	67943867	87326693	4338	8732										
PJA1	64219	broad.mit.edu	37	chrX	68381328	68381328	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgaccaactgcgccatgaTcttcagtgaccaggatctcg	9	14	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:68381328T>C	ENST00000361478.1	-	2	2131	c.1754A>G	c.(1753-1755)gAt>gGt	p.D585G	PJA1_ENST00000374571.4_Missense_Mutation_p.D530G|PJA1_ENST00000374583.1_Missense_Mutation_p.D585G|PJA1_ENST00000374584.3_Missense_Mutation_p.D397G	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	585							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						TGCGCCATGATCTTCAGTGAC	0.562													36	57					0	0	1	0	0	C	68381328	T	C	68381328	3	2	48	1	0	0	0	0	1	0	0	0	12008	1435	50	4	181	4	PJA1	23	68381328	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	437461	68381328	86889232	4339	8733										
IGBP1	3476	broad.mit.edu	37	chrX	69366640	69366640	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agattgagagcattgaccagGaaataaagatcctgagagaa	11	5	0	6			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:69366640G>A	ENST00000342206.6	+	3	1139	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	IGBP1_ENST00000356413.4_Missense_Mutation_p.E214K			P78318	IGBP1_HUMAN	immunoglobulin (CD79A) binding protein 1	214					B cell activation|negative regulation of caspase activity|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|regulation of microtubule-based movement|response to interleukin-1|response to tumor necrosis factor|signal transduction	cytoplasm	protein phosphatase type 2A regulator activity			kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(2)	11						CATTGACCAGGAAATAAAGAT	0.408													14	35					0	0	1	0	0	A	69366640	G	A	69366640	3	1	48	1	0	0	0	0	1	0	0	0	7610	1175	41	3	650	3	IGBP1	23	69366640	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	985312	69366640	85903920	4340	8734										
PDZD11	51248	broad.mit.edu	37	chrX	69507613	69507613	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatatcttggaaatccacaTcattcacagctagaacttgg	6	10	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:69507613T>C	ENST00000239666.4	-	5	428	c.296A>G	c.(295-297)gAt>gGt	p.D99G	PDZD11_ENST00000473667.1_5'UTR|PDZD11_ENST00000374454.1_Missense_Mutation_p.D99G	NM_016484.4	NP_057568.1	Q5EBL8	PDZ11_HUMAN	PDZ domain containing 11	99	PDZ.					basolateral plasma membrane|cytosol|extracellular region	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(3)|lung(3)	9						GAAATCCACATCATTCACAGC	0.473													23	46					0	0	1	0	0	C	69507613	T	C	69507613	3	2	48	1	0	0	0	0	1	0	0	0	11746	1435	50	4	138	4	PDZD11	23	69507613	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	140973	69507613	85762947	4341	8735										
GDPD2	54857	broad.mit.edu	37	chrX	69652184	69652184	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cataaggataatgtctcggtGaacctatttgtagtgaacaa	9	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:69652184G>T	ENST00000453994.2	+	14	1849	c.1488G>T	c.(1486-1488)gtG>gtT	p.V496V	GDPD2_ENST00000536730.1_Silent_p.V366V|GDPD2_ENST00000374382.3_Silent_p.V445V|GDPD2_ENST00000472623.1_3'UTR|GDPD2_ENST00000538649.1_Silent_p.V366V	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	445					glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					ATGTCTCGGTGAACCTATTTG	0.537													42	89					1.91658e-06	2.15367e-06	1	1	0	T	69652184	G	T	69652184	2	4	48	1	0	0	0	0	0	0	0	1	6365	1277	45	2		2	GDPD2	23	69652184	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	144571	69652184	85618376	4342	8736										
TEX11	0	broad.mit.edu	37	chrX	69890345	69890345	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aataatagtaccattgtaggGcatcagtgtaattttgtacc	8	6	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:69890345G>A	ENST00000395889.2	-	17	1462	c.1307C>T	c.(1306-1308)gCc>gTc	p.A436V	TEX11_ENST00000374333.2_Missense_Mutation_p.A421V|TEX11_ENST00000374320.2_Missense_Mutation_p.A111V|TEX11_ENST00000344304.3_Missense_Mutation_p.A436V	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	436							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					CCATTGTAGGGCATCAGTGTA	0.378													13	33					0	0	1	0	0	A	69890345	G	A	69890345	3	1	48	1	0	0	0	0	1	0	0	0	15832	1203	42	3	1575	3	TEX11	23	69890345	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	238161	69890345	85380215	4343	8737										
MED12	9968	broad.mit.edu	37	chrX	70344099	70344099	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatgatgttttctcccacaAcatgtatacttgcactctca	4	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70344099A>C	ENST00000333646.6	+	13	2034	c.1835A>C	c.(1834-1836)aAc>aCc	p.N612T	MED12_ENST00000374080.3_Missense_Mutation_p.N612T|MED12_ENST00000374102.1_Missense_Mutation_p.N612T	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	612					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TTCTCCCACAACATGTATACT	0.537			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						22	33					0	0	1	0	0	C	70344099	A	C	70344099	3	2	48	1	0	0	0	0	1	0	0	0	9477	43	2	4	1885	4	MED12	23	70344099	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	453754	70344099	84926461	4344	8738										
MED12	9968	broad.mit.edu	37	chrX	70352363	70352363	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgggttcctcttcacgcaaaGaacgtgatcgacaaaagcag	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70352363G>T	ENST00000333646.6	+	31	4589	c.4390G>T	c.(4390-4392)Gaa>Taa	p.E1464*	MED12_ENST00000478889.1_Intron|MED12_ENST00000374080.3_Nonsense_Mutation_p.E1464*|MED12_ENST00000374102.1_Nonsense_Mutation_p.E1464*	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1464					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TTCACGCAAAGAACGTGATCG	0.517			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						7	13					0.00198382	0.00207034	1	1	0	T	70352363	G	T	70352363	4	4	48	1	0	0	0	0	0	1	0	0	9477	943	33	2	4512	2	MED12	23	70352363	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8264	70352363	84918197	4345	8739										
NLGN3	54413	broad.mit.edu	37	chrX	70375128	70375128	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggaggctcttacatggaaggGacaggcaacatgattgatgg	15	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70375128G>A	ENST00000374051.3	+	4	904	c.582G>A	c.(580-582)ggG>ggA	p.G194G	NLGN3_ENST00000536169.1_Silent_p.G174G|NLGN3_ENST00000358741.3_Silent_p.G214G|NLGN3_ENST00000476589.1_3'UTR	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	214					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					ACATGGAAGGGACAGGCAACA	0.552													29	55					0	0	1	0	0	A	70375128	G	A	70375128	2	1	48	1	0	0	0	0	0	0	0	1	10509	1161	41	3		3	NLGN3	23	70375128	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	22765	70375128	84895432	4346	8740										
GJB1	2705	broad.mit.edu	37	chrX	70444064	70444064	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgcggctggtcaagtgcgaCgtctacccctgccccaacac	11	16	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70444064C>T	ENST00000374022.3	+	2	602	c.507C>T	c.(505-507)gaC>gaT	p.D169D	GJB1_ENST00000361726.6_Silent_p.D169D|GJB1_ENST00000374029.1_Silent_p.D169D	NM_001097642.2	NP_001091111.1	P08034	CXB1_HUMAN	gap junction protein, beta 1, 32kDa	169					cell-cell signaling|cellular membrane organization|gap junction assembly|nervous system development	connexon complex|endoplasmic reticulum membrane|integral to membrane	gap junction channel activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(1)	10	Renal(35;0.156)					TCAAGTGCGACGTCTACCCCT	0.562													5	24					0	0	1	0	0	T	70444064	C	T	70444064	2	4	48	1	0	0	0	0	0	0	0	1	6448	535	19	1		1	GJB1	23	70444064	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	68936	70444064	84826496	4347	8741										
ZMYM3	9203	broad.mit.edu	37	chrX	70460939	70460939	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggtagaacacatcgttgcGagtccggaggctttcaggac	13	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70460939G>A	ENST00000373998.1	-	25	4601	c.3904C>T	c.(3904-3906)Cgc>Tgc	p.R1302C	ZMYM3_ENST00000373984.3_Missense_Mutation_p.R1224C|ZMYM3_ENST00000353904.2_Missense_Mutation_p.R1314C|ZMYM3_ENST00000314425.5_Missense_Mutation_p.R1314C|ZMYM3_ENST00000373988.1_Missense_Mutation_p.R1316C|ZMYM3_ENST00000489332.1_5'UTR	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1314					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					ACATCGTTGCGAGTCCGGAGG	0.577													14	20					0	0	1	0	0	A	70460939	G	A	70460939	3	1	48	1	0	0	0	0	1	0	0	0	17758	1058	37	1	176	1	ZMYM3	23	70460939	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	16875	70460939	84809621	4348	8742										
ZMYM3	9203	broad.mit.edu	37	chrX	70461091	70461091	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actcaccattttgagagataGaattcatagaacttgacagg	8	7	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70461091G>T	ENST00000373998.1	-	24	4567	c.3870C>A	c.(3868-3870)ttC>ttA	p.F1290L	ZMYM3_ENST00000373984.3_Missense_Mutation_p.F1212L|ZMYM3_ENST00000353904.2_Missense_Mutation_p.F1302L|ZMYM3_ENST00000314425.5_Missense_Mutation_p.F1302L|ZMYM3_ENST00000373988.1_Missense_Mutation_p.F1304L|ZMYM3_ENST00000489332.1_5'UTR	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1302					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TTGAGAGATAGAATTCATAGA	0.517													21	34					1.55795e-14	2.03067e-14	1	1	0	T	70461091	G	T	70461091	3	4	48	1	0	0	0	0	1	0	0	0	17758	933	33	2	214	2	ZMYM3	23	70461091	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	152	70461091	84809469	4349	8743										
ZMYM3	9203	broad.mit.edu	37	chrX	70470017	70470017	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggagcctccagaaccagtCtgcgccacaaccgagtcctt	9	15	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70470017C>T	ENST00000373978.1	-	5	898	c.821G>A	c.(820-822)aGa>aAa	p.R274K	ZMYM3_ENST00000373984.3_Silent_p.Q372Q|ZMYM3_ENST00000353904.2_Silent_p.Q370Q|ZMYM3_ENST00000314425.5_Silent_p.Q370Q|ZMYM3_ENST00000373981.1_Silent_p.Q370Q|ZMYM3_ENST00000373998.1_Silent_p.Q370Q|ZMYM3_ENST00000373988.1_Silent_p.Q372Q|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373982.1_Silent_p.Q372Q			Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	178					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					CAGAACCAGTCTGCGCCACAA	0.577													19	19					0	0	1	0	0	T	70470017	C	T	70470017	3	4	48	1	0	0	0	0	1	0	0	0	17758	912	32	3	3100	3	ZMYM3	23	70470017	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8926	70470017	84800543	4350	8744										
NONO	4841	broad.mit.edu	37	chrX	70514336	70514336	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agggaagccagctgctcggaAagctctggacagatgcagtg	15	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70514336A>C	ENST00000535149.1	+	3	984	c.341A>C	c.(340-342)aAa>aCa	p.K114T	NONO_ENST00000373841.1_Missense_Mutation_p.K203T|NONO_ENST00000490044.1_3'UTR|NONO_ENST00000276079.8_Missense_Mutation_p.K203T|NONO_ENST00000373856.3_Missense_Mutation_p.K203T	NM_001145410.1	NP_001138882.1	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	203	DBHS.|RRM 1.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	19	Renal(35;0.156)					GCTGCTCGGAAAGCTCTGGAC	0.507			T	TFE3	papillary renal cancer								7	31					0	0	1	0	0	C	70514336	A	C	70514336	3	2	48	1	0	0	0	0	1	0	0	0	10580	14	1	4	618	4	NONO	23	70514336	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	44319	70514336	84756224	4351	8745										
OGT	8473	broad.mit.edu	37	chrX	70757899	70757899	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaggggcagtacaagcttacGtctctgctcttcagtacaat	9	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70757899G>A	ENST00000373719.3	+	3	656	c.439G>A	c.(439-441)Gtc>Atc	p.V147I	OGT_ENST00000373701.3_Missense_Mutation_p.V137I|OGT_ENST00000498566.1_3'UTR	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	147					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					ACAAGCTTACGTCTCTGCTCT	0.428													13	21					0	0	1	0	0	A	70757899	G	A	70757899	3	1	48	1	0	0	0	0	1	0	0	0	10894	1145	40	1	449	1	OGT	23	70757899	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	243563	70757899	84512661	4352	8746										
OGT	8473	broad.mit.edu	37	chrX	70793483	70793483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacccagcctgaagaaagttCgtggcaaagtctggaagcaa	11	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70793483C>T	ENST00000373719.3	+	22	3197	c.2980C>T	c.(2980-2982)Cgt>Tgt	p.R994C	OGT_ENST00000373701.3_Missense_Mutation_p.R984C	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	994					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity	p.R994C(1)|p.R984C(1)		breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GAAGAAAGTTCGTGGCAAAGT	0.418													16	33					0	0	1	0	0	T	70793483	C	T	70793483	3	4	48	1	0	0	0	0	1	0	0	0	10894	884	31	1	3066	1	OGT	23	70793483	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	35584	70793483	84477077	4353	8747										
ACRC	93953	broad.mit.edu	37	chrX	70823530	70823530	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgacgatgacaacggtaatGatttggaagttcccgacgac	11	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70823530G>T	ENST00000373695.1	+	7	940	c.403G>T	c.(403-405)Gat>Tat	p.D135Y	ACRC_ENST00000373696.3_Missense_Mutation_p.D135Y			Q96QF7	ACRC_HUMAN	acidic repeat containing	135	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CAACGGTAATGATTTGGAAGT	0.463													86	161					6.71967e-41	9.7083e-41	1	1	0	T	70823530	G	T	70823530	3	4	48	1	0	0	0	0	1	0	0	0	171	1290	45	2	429	2	ACRC	23	70823530	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	30047	70823530	84447030	4354	8748										
ACRC	93953	broad.mit.edu	37	chrX	70832208	70832208	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcattcttctttcaagaccGaatccgggataccttgatcc	6	12	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70832208G>A	ENST00000373695.1	+	11	2291	c.1754G>A	c.(1753-1755)cGa>cAa	p.R585Q	ACRC_ENST00000471950.1_3'UTR|ACRC_ENST00000373696.3_Missense_Mutation_p.R585Q			Q96QF7	ACRC_HUMAN	acidic repeat containing	585						nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					TTTCAAGACCGAATCCGGGAT	0.378													7	11					0	0	1	0	0	A	70832208	G	A	70832208	3	1	48	1	0	0	0	0	1	0	0	0	171	1058	37	1	1796	1	ACRC	23	70832208	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	8678	70832208	84438352	4355	8749										
ACRC	93953	broad.mit.edu	37	chrX	70832407	70832407	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaatgtactggatgcaaaacGaggtaagactcttctcagac	10	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:70832407G>A	ENST00000373695.1	+	11	2490	c.1953G>A	c.(1951-1953)acG>acA	p.T651T	ACRC_ENST00000471950.1_3'UTR|ACRC_ENST00000373696.3_Silent_p.T651T			Q96QF7	ACRC_HUMAN	acidic repeat containing	651						nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					GATGCAAAACGAGGTAAGACT	0.458													13	14					0	0	1	0	0	A	70832407	G	A	70832407	2	1	48	1	0	0	0	0	0	0	0	1	171	1045	37	1		1	ACRC	23	70832407	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	199	70832407	84438153	4356	8750										
NHSL2	340527	broad.mit.edu	37	chrX	71358707	71358707	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcccacctctggttcctaagGaggctgctaccctccttgtc	8	16	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:71358707G>A	ENST00000373677.1	+	2	1473	c.211G>A	c.(211-213)Gag>Aag	p.E71K	NHSL2_ENST00000510661.1_Missense_Mutation_p.E206K|NHSL2_ENST00000535692.1_Missense_Mutation_p.E71K|NHSL2_ENST00000540800.1_Missense_Mutation_p.E437K			F5H593	F5H593_HUMAN	NHS-like 2	437										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					GGTTCCTAAGGAGGCTGCTAC	0.522													14	28					0	0	1	0	0	A	71358707	G	A	71358707	3	1	48	1	0	0	0	0	1	0	0	0	10458	1175	41	3	1331	3	NHSL2	23	71358707	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	526300	71358707	83911853	4357	8751										
NHSL2	340527	broad.mit.edu	37	chrX	71359836	71359836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtcaagctggcccagaaaaCtaatcccaaccagccaatca	6	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:71359836C>T	ENST00000373677.1	+	2	2602	c.1340C>T	c.(1339-1341)aCt>aTt	p.T447I	NHSL2_ENST00000510661.1_Missense_Mutation_p.T582I|NHSL2_ENST00000535692.1_Missense_Mutation_p.T447I|NHSL2_ENST00000540800.1_Missense_Mutation_p.T813I			F5H593	F5H593_HUMAN	NHS-like 2	813										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					GCCCAGAAAACTAATCCCAAC	0.502													9	19					0	0	1	0	0	T	71359836	C	T	71359836	3	4	48	1	0	0	0	0	1	0	0	0	10458	565	20	3	2460	3	NHSL2	23	71359836	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1129	71359836	83910724	4358	8752										
ERCC6L	54821	broad.mit.edu	37	chrX	71425104	71425104	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaggggcaccaagagaggtCtcttgagctagagcactagg	14	9	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:71425104C>A	ENST00000373657.1	-	3	3746	c.3144G>T	c.(3142-3144)gaG>gaT	p.E1048D	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Missense_Mutation_p.E1171D			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	1171					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					CAAGAGAGGTCTCTTGAGCTA	0.488													34	41					4.3181e-19	5.86915e-19	1	1	0	A	71425104	C	A	71425104	3	1	48	1	0	0	0	0	1	0	0	0	5246	912	32	2	243	2	ERCC6L	23	71425104	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	65268	71425104	83845456	4359	8753										
ERCC6L	54821	broad.mit.edu	37	chrX	71425342	71425342	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagacctcctagaagccagaGatcttctagagttcatagac	9	10	3	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:71425342G>T	ENST00000373657.1	-	3	3508	c.2906C>A	c.(2905-2907)tCt>tAt	p.S969Y	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Missense_Mutation_p.S1092Y			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	1092					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					AGAAGCCAGAGATCTTCTAGA	0.418													21	54					2.37509e-13	3.04217e-13	1	1	0	T	71425342	G	T	71425342	3	4	48	1	0	0	0	0	1	0	0	0	5246	942	33	2	481	2	ERCC6L	23	71425342	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	238	71425342	83845218	4360	8754										
PHKA1	5255	broad.mit.edu	37	chrX	71802319	71802319	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgatgcttccgatgctatGaatttcaatatctgccagca	7	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:71802319G>T	ENST00000373545.3	-	31	3739	c.3301C>A	c.(3301-3303)Cat>Aat	p.H1101N	PHKA1_ENST00000541944.1_Missense_Mutation_p.H1071N|PHKA1_ENST00000373542.4_Missense_Mutation_p.H1143N|PHKA1_ENST00000373539.3_Missense_Mutation_p.H1160N|PHKA1_ENST00000339490.3_Missense_Mutation_p.H1130N			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	1143					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CCGATGCTATGAATTTCAATA	0.448													18	37					1.02788e-11	1.28326e-11	1	1	0	T	71802319	G	T	71802319	3	4	48	1	0	0	0	0	1	0	0	0	11890	1290	45	2	252	2	PHKA1	23	71802319	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	376977	71802319	83468241	4361	8755										
NAP1L2	4674	broad.mit.edu	37	chrX	72433253	72433253	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaaatcttcagttacagttCggattgttccccagatccga	8	10	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:72433253C>T	ENST00000373517.3	-	1	1431	c.1076G>A	c.(1075-1077)cGa>cAa	p.R359Q	NAP1L2_ENST00000536638.1_Missense_Mutation_p.R217Q	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	359					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					AGTTACAGTTCGGATTGTTCC	0.373													25	41					0	0	1	0	0	T	72433253	C	T	72433253	3	4	48	1	0	0	0	0	1	0	0	0	10204	884	31	1	310	1	NAP1L2	23	72433253	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	630934	72433253	82837307	4362	8756										
NAP1L2	4674	broad.mit.edu	37	chrX	72433721	72433721	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcataataatagtcctcaTaaccatcgtcctcatccaca	2	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:72433721T>A	ENST00000373517.3	-	1	963	c.608A>T	c.(607-609)tAt>tTt	p.Y203F	NAP1L2_ENST00000536638.1_Missense_Mutation_p.Y61F	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	203	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					ATAGTCCTCATAACCATCGTC	0.443													31	35					0	0	1	0	0	A	72433721	T	A	72433721	3	1	48	1	0	0	0	0	1	0	0	0	10204	1406	49	4	778	4	NAP1L2	23	72433721	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	468	72433721	82836839	4363	8757										
RLIM	51132	broad.mit.edu	37	chrX	73811355	73811355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agaattctcagataaccagcGatcgatgcagtggacatggt	11	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:73811355G>A	ENST00000332687.6	-	4	2013	c.1795C>T	c.(1795-1797)Cgc>Tgc	p.R599C	RLIM_ENST00000349225.2_Missense_Mutation_p.R599C	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	599					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GATAACCAGCGATCGATGCAG	0.408													37	47					0	0	1	0	0	A	73811355	G	A	73811355	3	1	48	1	0	0	0	0	1	0	0	0	13441	1058	37	1	83	1	RLIM	23	73811355	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1377634	73811355	81459205	4364	8758										
ABCB7	22	broad.mit.edu	37	chrX	74282175	74282175	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taacttacctcttcagtaatCgaatctaacgatgaagtagc	6	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:74282175C>T	ENST00000253577.3	-	14	1950	c.1926G>A	c.(1924-1926)tcG>tcA	p.S642S	ABCB7_ENST00000373394.3_Silent_p.S641S|ABCB7_ENST00000339447.4_Silent_p.S601S	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	641	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						CTTCAGTAATCGAATCTAACG	0.353													11	16					0	0	1	0	0	T	74282175	C	T	74282175	2	4	48	1	0	0	0	0	0	0	0	1	46	871	31	1		1	ABCB7	23	74282175	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	470820	74282175	80988385	4365	8759										
ABCB7	22	broad.mit.edu	37	chrX	74318853	74318853	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctttgggccacacataaGaaagcattgcttttatgatt	8	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:74318853G>T	ENST00000253577.3	-	4	404	c.380C>A	c.(379-381)tCt>tAt	p.S127Y	ABCB7_ENST00000373394.3_Missense_Mutation_p.S126Y|ABCB7_ENST00000339447.4_Intron	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	126					cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						CCACACATAAGAAAGCATTGC	0.373													18	36					3.52763e-06	3.92945e-06	1	1	0	T	74318853	G	T	74318853	3	4	48	1	0	0	0	0	1	0	0	0	46	942	33	2	1933	2	ABCB7	23	74318853	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	36678	74318853	80951707	4366	8760										
MAGEE1	57692	broad.mit.edu	37	chrX	75650001	75650001	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgaggcacacacctacattCtgttaaacaaactgggacct	7	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:75650001C>A	ENST00000361470.2	+	1	1956	c.1678C>A	c.(1678-1680)Ctg>Atg	p.L560M		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	560	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CACCTACATTCTGTTAAACAA	0.483													12	26					0.00010058	0.000108553	1	1	0	A	75650001	C	A	75650001	3	1	48	1	0	0	0	0	1	0	0	0	9234	912	32	2	1680	2	MAGEE1	23	75650001	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1331148	75650001	79620559	4367	8761										
ATRX	546	broad.mit.edu	37	chrX	76813007	76813007	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gctcaaaagtataaagttcaGtaagctcattcatagtaaaa	6	6	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:76813007G>T	ENST00000373344.5	-	30	6828	c.6614C>A	c.(6613-6615)aCt>aAt	p.T2205N	ATRX_ENST00000395603.3_Missense_Mutation_p.T2167N|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2205	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	ATAAAGTTCAGTAAGCTCATT	0.383			"Mis, F, N"		"Pancreatic neuroendocrine tumors, paediatric GBM"		ATR-X (alpha thalassemia/mental retardation) syndrome						14	94					1.05317e-09	1.27574e-09	1	1	0	T	76813007	G	T	76813007	3	4	48	1	0	0	0	0	1	0	0	0	1206	1029	36	5	888	5	ATRX	23	76813007	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1163006	76813007	78457553	4368	8762										
ATRX	546	broad.mit.edu	37	chrX	76888737	76888737	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatatttctttaagtttccGactcttcacattccttcctt	2	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:76888737G>A	ENST00000373344.5	-	19	5306	c.5092C>T	c.(5092-5094)Cgg>Tgg	p.R1698W	ATRX_ENST00000395603.3_Missense_Mutation_p.R1660W|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1698	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTAAGTTTCCGACTCTTCACA	0.358			"Mis, F, N"		"Pancreatic neuroendocrine tumors, paediatric GBM"		ATR-X (alpha thalassemia/mental retardation) syndrome						33	206					0	0	1	0	0	A	76888737	G	A	76888737	3	1	48	1	0	0	0	0	1	0	0	0	1206	1057	37	1	2454	1	ATRX	23	76888737	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	75730	76888737	78381823	4369	8763										
ATRX	546	broad.mit.edu	37	chrX	76907620	76907620	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacctctctcaatttttctCgctcacgctccctctcagca	3	17	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:76907620C>T	ENST00000373344.5	-	15	4755	c.4541G>A	c.(4540-4542)cGa>cAa	p.R1514Q	ATRX_ENST00000395603.3_Missense_Mutation_p.R1476Q|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1514					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CAATTTTTCTCGCTCACGCTC	0.428			"Mis, F, N"		"Pancreatic neuroendocrine tumors, paediatric GBM"		ATR-X (alpha thalassemia/mental retardation) syndrome						12	150					0	0	1	0	0	T	76907620	C	T	76907620	3	4	48	1	0	0	0	0	1	0	0	0	1206	884	31	1	3021	1	ATRX	23	76907620	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	18883	76907620	78362940	4370	8764										
LPAR4	2846	broad.mit.edu	37	chrX	78010799	78010799	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggccattgtctatccttttCgatctcgtactattaggact	7	10	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:78010799C>T	ENST00000435339.2	+	2	838	c.433C>T	c.(433-435)Cga>Tga	p.R145*	LPAR4_ENST00000373301.2_Nonsense_Mutation_p.R145*	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	145						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						CTATCCTTTTCGATCTCGTAC	0.463													35	69					0	0	1	0	0	T	78010799	C	T	78010799	4	4	48	1	0	0	0	0	0	1	0	0	8951	876	31	1	435	1	LPAR4	23	78010799	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1103179	78010799	77259761	4371	8765										
P2RY10	0	broad.mit.edu	37	chrX	78216975	78216975	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgaccaactatcccgccatGgcagttctgtgacccgctcc	9	16	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:78216975G>T	ENST00000171757.2	+	4	1238	c.958G>T	c.(958-960)Ggc>Tgc	p.G320C	P2RY10_ENST00000544091.1_Missense_Mutation_p.G320C	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	320						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						ATCCCGCCATGGCAGTTCTGT	0.448													6	105					0.000673444	0.000709932	1	1	0	T	78216975	G	T	78216975	3	4	48	1	0	0	0	0	1	0	0	0	11393	1348	47	5	960	5	P2RY10	23	78216975	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	206176	78216975	77053585	4372	8766										
BRWD3	254065	broad.mit.edu	37	chrX	79932179	79932179	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acgcactctgcctgatctggAtgtaccaagattcagaggat	10	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:79932179A>G	ENST00000373275.4	-	41	5554	c.5338T>C	c.(5338-5340)Tcc>Ccc	p.S1780P		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1780										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CCTGATCTGGATGTACCAAGA	0.348													18	22					0	0	1	0	0	G	79932179	A	G	79932179	3	3	48	1	0	0	0	0	1	0	0	0	1528	333	12	4	74	4	BRWD3	23	79932179	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1715204	79932179	75338381	4373	8767										
BRWD3	254065	broad.mit.edu	37	chrX	79932799	79932799	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgatgcactaagtagttttCtcttgattcctgtccggggc	10	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:79932799C>A	ENST00000373275.4	-	41	4934	c.4718G>T	c.(4717-4719)aGa>aTa	p.R1573I	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1573										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AAGTAGTTTTCTCTTGATTCC	0.368													16	18					2.23348e-06	2.50077e-06	1	1	0	A	79932799	C	A	79932799	3	1	48	1	0	0	0	0	1	0	0	0	1528	913	32	2	694	2	BRWD3	23	79932799	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	620	79932799	75337761	4374	8768										
BRWD3	254065	broad.mit.edu	37	chrX	79947407	79947407	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccccactctccttcctggggTttgtatagcaaagcagtcaa	8	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:79947407T>C	ENST00000373275.4	-	30	3612	c.3396A>G	c.(3394-3396)aaA>aaG	p.K1132K	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1132										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CTTCCTGGGGTTTGTATAGCA	0.448													11	23					0	0	1	0	0	C	79947407	T	C	79947407	2	2	48	1	0	0	0	0	0	0	0	1	1528	1722	60	4		4	BRWD3	23	79947407	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	14608	79947407	75323153	4375	8769										
BRWD3	254065	broad.mit.edu	37	chrX	79951425	79951425	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accaatctgccagttcctttCtttggcttcattataaaact	4	11	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:79951425C>A	ENST00000373275.4	-	27	3349	c.3133G>T	c.(3133-3135)Gaa>Taa	p.E1045*	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1045										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CAGTTCCTTTCTTTGGCTTCA	0.308													6	15					0.00198382	0.00207034	1	1	0	A	79951425	C	A	79951425	4	1	48	1	0	0	0	0	0	1	0	0	1528	922	32	2	2335	2	BRWD3	23	79951425	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4018	79951425	75319135	4376	8770										
BRWD3	254065	broad.mit.edu	37	chrX	79979252	79979252	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttaaatatgctaaccttttCgtagtatttactgcatccaa	4	8	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:79979252C>T	ENST00000373275.4	-	16	1861	c.1645G>A	c.(1645-1647)Gaa>Aaa	p.E549K		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	549										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						ctaacctttTCGTAGTATTTA	0.343													16	24					0	0	1	0	0	T	79979252	C	T	79979252	3	4	48	1	0	0	0	0	1	0	0	0	1528	893	31	1	3867	1	BRWD3	23	79979252	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	27827	79979252	75291308	4377	8771										
BRWD3	254065	broad.mit.edu	37	chrX	79980449	79980449	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	taccatgttaaagtaattccGaattttggtcccccggtcaa	7	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:79980449G>A	ENST00000373275.4	-	15	1720	c.1504C>T	c.(1504-1506)Cgg>Tgg	p.R502W		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	502										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AAGTAATTCCGAATTTTGGTC	0.368													13	29					0	0	1	0	0	A	79980449	G	A	79980449	3	1	48	1	0	0	0	0	1	0	0	0	1528	1057	37	1	4012	1	BRWD3	23	79980449	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1197	79980449	75290111	4378	8772										
POU3F4	5456	broad.mit.edu	37	chrX	82763427	82763427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagcaggggagtcctttccGcaaccctcagaaacttctcc	9	15	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:82763427G>A	ENST00000373200.2	+	1	159	c.95G>A	c.(94-96)cGc>cAc	p.R32H	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	32					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						AGTCCTTTCCGCAACCCTCAG	0.597													18	23					0	0	1	0	0	A	82763427	G	A	82763427	3	1	48	1	0	0	0	0	1	0	0	0	12322	1087	38	1	97	1	POU3F4	23	82763427	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2782978	82763427	72507133	4379	8773										
POU3F4	5456	broad.mit.edu	37	chrX	82764037	82764037	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaccaccatctgcaggttCgaaggcttgcagctgagctt	11	12	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:82764037C>A	ENST00000373200.2	+	1	769	c.705C>A	c.(703-705)ttC>ttA	p.F235L	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	235	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						TCTGCAGGTTCGAAGGCTTGC	0.562													25	51					2.47511e-08	2.91589e-08	1	1	0	A	82764037	C	A	82764037	3	1	48	1	0	0	0	0	1	0	0	0	12322	883	31	2	707	2	POU3F4	23	82764037	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	610	82764037	72506523	4380	8774										
CYLC1	1538	broad.mit.edu	37	chrX	83127903	83127903	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatcttttcagagacatgacAaaagaaaactagaagaaggc	8	6	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:83127903A>C	ENST00000329312.4	+	4	224	c.187A>C	c.(187-189)Aaa>Caa	p.K63Q		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	63					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						GAGACATGACAAAAGAAAACT	0.318													5	15					0	0	1	0	0	C	83127903	A	C	83127903	3	2	48	1	0	0	0	0	1	0	0	0	4164	131	5	4	201	4	CYLC1	23	83127903	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	363866	83127903	72142657	4381	8775										
HDX	139324	broad.mit.edu	37	chrX	83730395	83730395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttctacagtaaatacagaaCgtagattcatctaaaaataa	5	6	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:83730395C>T	ENST00000297977.5	-	2	122	c.11G>A	c.(10-12)cGt>cAt	p.R4H	HDX_ENST00000506585.2_Intron|HDX_ENST00000373177.2_Missense_Mutation_p.R4H	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	4						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R4H(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						AAATACAGAACGTAGATTCAT	0.269													9	17					0	0	1	0	0	T	83730395	C	T	83730395	3	4	48	1	0	0	0	0	1	0	0	0	7066	536	19	1	2097	1	HDX	23	83730395	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	602492	83730395	71540165	4382	8776										
APOOL	139322	broad.mit.edu	37	chrX	84301495	84301495	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcaggtctgatatatgcatCtgtaagtgtacatgcagcca	10	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:84301495C>A	ENST00000373173.2	+	2	146	c.59C>A	c.(58-60)tCt>tAt	p.S20Y		NM_198450.5	NP_940852.3	Q6UXV4	APOOL_HUMAN	apolipoprotein O-like	20						extracellular region				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8						ATATATGCATCTGTAAGTGTA	0.358													10	25					5.50884e-06	6.10489e-06	1	1	0	A	84301495	C	A	84301495	3	1	48	1	0	0	0	0	1	0	0	0	811	913	32	2	65	2	APOOL	23	84301495	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	571100	84301495	70969065	4383	8777										
POF1B	79983	broad.mit.edu	37	chrX	84563198	84563198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtggacagcactagtcggaGtgacttatcagacatacccc	10	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:84563198G>A	ENST00000262753.4	-	10	1127	c.982C>T	c.(982-984)Ctc>Ttc	p.L328F	POF1B_ENST00000373145.3_Missense_Mutation_p.L328F	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	328							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						ACTAGTCGGAGTGACTTATCA	0.338													11	28					0	0	1	0	0	A	84563198	G	A	84563198	3	1	48	1	0	0	0	0	1	0	0	0	12229	1029	36	3	819	3	POF1B	23	84563198	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	261703	84563198	70707362	4384	8778										
DACH2	117154	broad.mit.edu	37	chrX	85404080	85404080	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatcaccaggaaagacttCgaaactttgttcaccgattg	7	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:85404080C>T	ENST00000373131.1	+	1	619	c.456C>T	c.(454-456)ttC>ttT	p.F152F	DACH2_ENST00000373125.4_Silent_p.F152F	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	152	DACHbox-N.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						GGAAAGACTTCGAAACTTTGT	0.577													15	35					0	0	1	0	0	T	85404080	C	T	85404080	2	4	48	1	0	0	0	0	0	0	0	1	4245	883	31	1		1	DACH2	23	85404080	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	840882	85404080	69866480	4385	8779										
DACH2	117154	broad.mit.edu	37	chrX	85631856	85631856	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaaatgacaagaaaacaagCtgttaacaggtatttatgta	8	5	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:85631856C>A	ENST00000373125.4	+	2	518	c.518C>A	c.(517-519)gCt>gAt	p.A173D	DACH2_ENST00000373131.1_Intron|DACH2_ENST00000508860.1_Missense_Mutation_p.A6D|DACH2_ENST00000510272.1_Intron	NM_053281.3	NP_444511.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						agaaaacaagctgttaacagg	0.338													3	3					0.00909568	0.00935351	1	1	0	A	85631856	C	A	85631856	3	1	48	1	0	0	0	0	1	0	0	0	4245	797	28	5	524	5	DACH2	23	85631856	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	227776	85631856	69638704	4386	8780										
DACH2	117154	broad.mit.edu	37	chrX	85969606	85969606	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctacttccagtcagcttaccTcctgcatcagttgccatggc	7	15	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:85969606T>C	ENST00000373131.1	+	5	1111	c.948T>C	c.(946-948)ccT>ccC	p.P316P	DACH2_ENST00000508860.1_Silent_p.P162P|DACH2_ENST00000373125.4_Silent_p.P329P|DACH2_ENST00000510272.1_Silent_p.P110P	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TCAGCTTACCTCCTGCATCAG	0.438													17	93					0	0	1	0	0	C	85969606	T	C	85969606	2	2	48	1	0	0	0	0	0	0	0	1	4245	1538	54	4		4	DACH2	23	85969606	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	337750	85969606	69300954	4387	8781										
KLHL4	0	broad.mit.edu	37	chrX	86924355	86924355	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caagaacttctacaaaacttCtataccacacagaagctgaa	4	11	2	3	rs12013438		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:86924355C>A	ENST00000373114.4	+	11	2204	c.2124C>A	c.(2122-2124)ttC>ttA	p.F708L	KLHL4_ENST00000373119.4_3'UTR	NM_057162.2	NP_476503.1	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	0						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TACAAAACTTCTATACCACAC	0.438													21	32					7.45023e-12	9.31775e-12	1	1	0	A	86924355	C	A	86924355	3	1	48	1	0	0	0	0	1	0	0	0	8433	912	32	2	2230	2	KLHL4	23	86924355	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	954749	86924355	68346205	4388	8782										
CPXCR1	53336	broad.mit.edu	37	chrX	88009147	88009147	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgtgtcacagatacaaatTgaaagtatttttaatataaa	5	3	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:88009147T>C	ENST00000276127.4	+	3	991	c.732T>C	c.(730-732)atT>atC	p.I244I	CPXCR1_ENST00000373111.1_Silent_p.I244I	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	244						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						AGATACAAATTGAAAGTATTT	0.318													8	4					0	0	1	0	0	C	88009147	T	C	88009147	2	2	48	1	0	0	0	0	0	0	0	1	3859	1800	63	4		4	CPXCR1	23	88009147	Silent	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1084792	88009147	67261413	4389	8783										
PABPC5	140886	broad.mit.edu	37	chrX	90690889	90690889	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	accgcttaagaaagtctggaGtgggaaatatattcatcaaa	9	6	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:90690889G>T	ENST00000312600.3	+	2	527	c.313G>T	c.(313-315)Gtg>Ttg	p.V105L	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	105						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						AAAGTCTGGAGTGGGAAATAT	0.413													7	75					0.0293803	0.0299069	1	1	0	T	90690889	G	T	90690889	3	4	48	1	0	0	0	0	1	0	0	0	11413	1029	36	5	315	5	PABPC5	23	90690889	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2681742	90690889	64579671	4390	8784										
PABPC5	140886	broad.mit.edu	37	chrX	90691338	90691338	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acacacgaggctgcccaaaaGgctgtgctagacttgcatgg	12	11	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:90691338G>T	ENST00000312600.3	+	2	976	c.762G>T	c.(760-762)aaG>aaT	p.K254N	PABPC5_ENST00000373105.1_Missense_Mutation_p.K90N	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	254	RRM 3.					cytoplasm	nucleotide binding|RNA binding	p.K254K(1)		central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						CTGCCCAAAAGGCTGTGCTAG	0.463													10	73					2.80697e-09	3.36108e-09	1	1	0	T	90691338	G	T	90691338	3	4	48	1	0	0	0	0	1	0	0	0	11413	991	35	5	764	5	PABPC5	23	90691338	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	449	90691338	64579222	4391	8785										
PCDH11X	27328	broad.mit.edu	37	chrX	91133602	91133602	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattaatgaactggtgcgcaAaagcactgaagcaccagtga	11	8	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:91133602A>C	ENST00000373094.1	+	2	3208	c.2363A>C	c.(2362-2364)aAa>aCa	p.K788T	PCDH11X_ENST00000361655.2_Missense_Mutation_p.K788T|PCDH11X_ENST00000361724.1_Missense_Mutation_p.K788T|PCDH11X_ENST00000298274.8_Missense_Mutation_p.K788T|PCDH11X_ENST00000406881.1_Missense_Mutation_p.K788T|PCDH11X_ENST00000373088.1_Missense_Mutation_p.K788T|PCDH11X_ENST00000395337.2_Missense_Mutation_p.K788T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.K788T|PCDH11X_ENST00000504220.1_Missense_Mutation_p.K788T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	788	Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CTGGTGCGCAAAAGCACTGAA	0.463													5	167					0	0	1	0	0	C	91133602	A	C	91133602	3	2	48	1	0	0	0	0	1	0	0	0	11554	14	1	4	2369	4	PCDH11X	23	91133602	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	442264	91133602	64136958	4392	8786										
NAP1L3	4675	broad.mit.edu	37	chrX	92927916	92927916	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atattttctttcaagatcatGaattgcttttaagaacaggg	7	5	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:92927916G>T	ENST00000373079.3	-	1	651	c.388C>A	c.(388-390)Cat>Aat	p.H130N	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	130					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TCAAGATCATGAATTGCTTTT	0.408													10	21					0.000442599	0.00046913	1	1	0	T	92927916	G	T	92927916	3	4	48	1	0	0	0	0	1	0	0	0	10205	1290	45	2	1136	2	NAP1L3	23	92927916	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1794314	92927916	62342644	4393	8787										
DIAPH2	1730	broad.mit.edu	37	chrX	96192338	96192338	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acaccgtctcaatgacattcGagcagaaatggaatatcctt	7	10	1	2	rs41300144		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:96192338G>A	ENST00000324765.8	+	11	1543	c.1196G>A	c.(1195-1197)cGa>cAa	p.R399Q	DIAPH2_ENST00000355827.4_Missense_Mutation_p.R399Q|DIAPH2_ENST00000373049.4_Missense_Mutation_p.R399Q|DIAPH2_ENST00000373054.4_Missense_Mutation_p.R395Q|DIAPH2_ENST00000373061.3_Missense_Mutation_p.R399Q			O60879	DIAP2_HUMAN	diaphanous-related formin 2	399	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding	p.R399Q(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						AATGACATTCGAGCAGAAATG	0.338													9	28					0	0	1	0	0	A	96192338	G	A	96192338	3	1	48	1	0	0	0	0	1	0	0	0	4547	1058	37	1	1238	1	DIAPH2	23	96192338	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3264422	96192338	59078222	4394	8788										
PCDH19	57526	broad.mit.edu	37	chrX	99657837	99657837	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttttgatgcccataggaGtactcagcaattctatgtga	8	8	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:99657837G>T	ENST00000373034.4	-	3	3976	c.2301C>A	c.(2299-2301)taC>taA	p.Y767*	PCDH19_ENST00000420881.2_Nonsense_Mutation_p.Y720*|PCDH19_ENST00000255531.7_Nonsense_Mutation_p.Y720*	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	767					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GCCCATAGGAGTACTCAGCAA	0.438													13	18					9.31168e-06	1.03131e-05	1	1	0	T	99657837	G	T	99657837	4	4	48	1	0	0	0	0	0	1	0	0	11560	1024	36	5	1161	5	PCDH19	23	99657837	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3465499	99657837	55612723	4395	8789										
PCDH19	57526	broad.mit.edu	37	chrX	99662932	99662932	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caccttgatactaaggccaaCggtgcccaggcgcggcgggt	14	13	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:99662932C>T	ENST00000373034.4	-	1	2339	c.664G>A	c.(664-666)Gtt>Att	p.V222I	PCDH19_ENST00000420881.2_Missense_Mutation_p.V222I|PCDH19_ENST00000255531.7_Missense_Mutation_p.V222I	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	222	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CTAAGGCCAACGGTGCCCAGG	0.607													56	99					0	0	1	0	0	T	99662932	C	T	99662932	3	4	48	1	0	0	0	0	1	0	0	0	11560	536	19	1	2806	1	PCDH19	23	99662932	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	5095	99662932	55607628	4396	8790										
TNMD	64102	broad.mit.edu	37	chrX	99852524	99852524	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagaaattaccacaactttCtttgaacagtcagtgatttg	7	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:99852524C>A	ENST00000373031.4	+	5	664	c.447C>A	c.(445-447)ttC>ttA	p.F149L	TNMD_ENST00000485971.1_3'UTR	NM_022144.2	NP_071427.2	Q9H2S6	TNMD_HUMAN	tenomodulin	149	BRICHOS.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(7)|skin(1)	16						CCACAACTTTCTTTGAACAGT	0.378													20	33					5.03518e-11	6.23768e-11	1	1	0	A	99852524	C	A	99852524	3	1	48	1	0	0	0	0	1	0	0	0	16381	912	32	2	465	2	TNMD	23	99852524	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	189592	99852524	55418036	4397	8791										
SRPX2	27286	broad.mit.edu	37	chrX	99922392	99922392	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgatattataaaatgcagatCtctatgctacaggtaaggcc	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:99922392C>A	ENST00000373004.3	+	9	1511	c.1083C>A	c.(1081-1083)atC>atA	p.I361I		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	361					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						AAATGCAGATCTCTATGCTAC	0.448													27	45					1.7881e-09	2.15438e-09	1	1	0	A	99922392	C	A	99922392	2	1	48	1	0	0	0	0	0	0	0	1	15220	903	32	2		2	SRPX2	23	99922392	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	69868	99922392	55348168	4398	8792										
CSTF2	1478	broad.mit.edu	37	chrX	100088308	100088308	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgtgcaatggaggcccgagcGatggaggcccgtgcaatgga	17	10	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100088308G>A	ENST00000415585.2	+	12	1429	c.1407G>A	c.(1405-1407)gcG>gcA	p.A469A	CSTF2_ENST00000372972.2_Silent_p.A449A|CSTF2_ENST00000486615.1_Intron			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	449	12 X 5 AA tandem repeats of M-E-A-R-[AG].				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						AGGCCCGAGCGATGGAGGCCC	0.622													9	15					0	0	1	0	0	A	100088308	G	A	100088308	2	1	48	1	0	0	0	0	0	0	0	1	4009	1045	37	1		1	CSTF2	23	100088308	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	165916	100088308	55182252	4399	8793										
NOX1	27035	broad.mit.edu	37	chrX	100099015	100099015	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atatcggtgacagcatttgcGcaggctctttgccaaagtcc	10	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100099015G>A	ENST00000372966.3	-	13	1826	c.1621C>T	c.(1621-1623)Cgc>Tgc	p.R541C	NOX1_ENST00000372960.4_Missense_Mutation_p.R504C|NOX1_ENST00000217885.5_Missense_Mutation_p.R492C|NOX1_ENST00000372964.1_Intron	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	541					angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						CAGCATTTGCGCAGGCTCTTT	0.423													9	16					0	0	1	0	0	A	100099015	G	A	100099015	3	1	48	1	0	0	0	0	1	0	0	0	10602	1087	38	1	77	1	NOX1	23	100099015	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	10707	100099015	55171545	4400	8794										
XKRX	402415	broad.mit.edu	37	chrX	100183298	100183298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cataaactctgtccattgtcGaggttctttctgaatgttgt	8	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100183298G>A	ENST00000328526.5	-	1	600	c.35C>T	c.(34-36)tCg>tTg	p.S12L	XKRX_ENST00000468904.1_5'UTR|XKRX_ENST00000372956.2_5'UTR	NM_212559.2	NP_997724.2	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	0						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						GTCCATTGTCGAGGTTCTTTC	0.498													94	195					0	0	1	0	0	A	100183298	G	A	100183298	3	1	48	1	0	0	0	0	1	0	0	0	17498	1073	37	1		1	XKRX	23	100183298	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	84283	100183298	55087262	4401	8795										
CENPI	2491	broad.mit.edu	37	chrX	100387279	100387279	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagcttgtgagctggattcCttttagtagcttctctggta	10	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100387279C>A	ENST00000372927.1	+	13	1665	c.1388C>A	c.(1387-1389)cCt>cAt	p.P463H	CENPI_ENST00000218507.5_Missense_Mutation_p.P463H|CENPI_ENST00000423383.1_Missense_Mutation_p.P463H|CENPI_ENST00000372926.1_Missense_Mutation_p.P463H	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	463					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						AGCTGGATTCCTTTTAGTAGC	0.388													49	88					1.67753e-36	2.4137e-36	1	1	0	A	100387279	C	A	100387279	3	1	48	1	0	0	0	0	1	0	0	0	3255	681	24	5	1434	5	CENPI	23	100387279	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	203981	100387279	54883281	4402	8796										
DRP2	1821	broad.mit.edu	37	chrX	100500053	100500053	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatttcacccaataaagttCcctactacatcaagtgagtg	5	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100500053C>T	ENST00000395209.3	+	10	1629	c.1102C>T	c.(1102-1104)Ccc>Tcc	p.P368S	DRP2_ENST00000541709.1_Missense_Mutation_p.P290S|DRP2_ENST00000538510.1_Missense_Mutation_p.P368S|DRP2_ENST00000402866.1_Missense_Mutation_p.P368S	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	368	WW.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						CAATAAAGTTCCCTACTACAT	0.493													83	168					0	0	1	0	0	T	100500053	C	T	100500053	3	4	48	1	0	0	0	0	1	0	0	0	4790	855	30	3	1132	3	DRP2	23	100500053	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	112774	100500053	54770507	4403	8797										
TAF7L	54457	broad.mit.edu	37	chrX	100530220	100530220	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttcttaccttctcatttTtttgtttttcctgtaactca	2	10	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100530220T>A	ENST00000372907.3	-	12	1345	c.1334A>T	c.(1333-1335)aAa>aTa	p.K445I	TAF7L_ENST00000356784.1_Missense_Mutation_p.K359I|TAF7L_ENST00000324762.6_Missense_Mutation_p.K285I|TAF7L_ENST00000372905.2_Missense_Mutation_p.K285I	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	445					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						CTTCTCATTTTTTTGTTTTTC	0.333													74	112					0	0	1	0	0	A	100530220	T	A	100530220	3	1	48	1	0	0	0	0	1	0	0	0	15589	1841	64	4	62	4	TAF7L	23	100530220	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	30167	100530220	54740340	4404	8798										
TAF7L	54457	broad.mit.edu	37	chrX	100532613	100532613	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgacgaggtatgaccctgCttgtggctgctcattcccga	11	13	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100532613C>T	ENST00000372907.3	-	9	941	c.930G>A	c.(928-930)aaG>aaA	p.K310K	TAF7L_ENST00000356784.1_Silent_p.K224K|TAF7L_ENST00000324762.6_Silent_p.K224K|TAF7L_ENST00000372905.2_Silent_p.K224K	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	310					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						TATGACCCTGCTTGTGGCTGC	0.438													60	140					0	0	1	0	0	T	100532613	C	T	100532613	2	4	48	1	0	0	0	0	0	0	0	1	15589	796	28	3		3	TAF7L	23	100532613	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2393	100532613	54737947	4405	8799										
GLA	2717	broad.mit.edu	37	chrX	100653892	100653892	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcatcaatgtcagcaaaatTtcgccagtgattgcagtact	7	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:100653892T>G	ENST00000218516.3	-	5	703	c.682A>C	c.(682-684)Aat>Cat	p.N228H	GLA_ENST00000493905.1_5'UTR|RPL36A-HNRNPH2_ENST00000409170.3_Intron	NM_000169.2	NP_000160.1	P06280	AGAL_HUMAN	galactosidase, alpha	228					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14					Agalsidase beta(DB00103)	TCAGCAAAATTTCGCCAGTGA	0.398													55	74					0	0	1	0	0	G	100653892	T	G	100653892	3	3	48	1	0	0	0	0	1	0	0	0	6467	1841	64	4	619	4	GLA	23	100653892	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	121279	100653892	54616668	4406	8800										
ZMAT1	84460	broad.mit.edu	37	chrX	101139144	101139144	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtgtttctacagagctatCtcctatctttctgaaacaag	7	9	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101139144C>A	ENST00000372782.3	-	7	1302	c.1255G>T	c.(1255-1257)Gat>Tat	p.D419Y	ZMAT1_ENST00000458570.1_Missense_Mutation_p.D248Y|ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000540921.1_Missense_Mutation_p.D419Y	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	248						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						ACAGAGCTATCTCCTATCTTT	0.403													17	210					2.48551e-13	3.17925e-13	1	1	0	A	101139144	C	A	101139144	3	1	48	1	0	0	0	0	1	0	0	0	17748	913	32	2	665	2	ZMAT1	23	101139144	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	485252	101139144	54131416	4407	8801										
ZMAT1	84460	broad.mit.edu	37	chrX	101139766	101139766	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttgtgtcttccttgaattCttcactagattgataacaat	5	8	4	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101139766C>A	ENST00000372782.3	-	7	680	c.633G>T	c.(631-633)aaG>aaT	p.K211N	ZMAT1_ENST00000458570.1_Missense_Mutation_p.K40N|ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000540921.1_Missense_Mutation_p.K211N	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	40						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						TCCTTGAATTCTTCACTAGAT	0.313													45	93					9.39024e-22	1.29924e-21	1	1	0	A	101139766	C	A	101139766	3	1	48	1	0	0	0	0	1	0	0	0	17748	912	32	2	1287	2	ZMAT1	23	101139766	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	622	101139766	54130794	4408	8802										
NXF2B	728343	broad.mit.edu	37	chrX	101623766	101623766	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcacagagtagggcgcagtaGaatgattgacaaatatacat	10	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101623766G>T	ENST00000457521.2	-	19	2467	c.596C>A	c.(595-597)tCt>tAt	p.S199Y	NXF2B_ENST00000372749.1_Missense_Mutation_p.S199Y|NXF2B_ENST00000372750.1_Missense_Mutation_p.S199Y|NXF2B_ENST00000372752.1_Missense_Mutation_p.S111Y|NXF2B_ENST00000412230.2_Missense_Mutation_p.S199Y					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						GGGCGCAGTAGAATGATTGAC	0.488													12	62					1.06801e-11	1.33247e-11	1	1	0	T	101623766	G	T	101623766	3	4	48	1	0	0	0	0	1	0	0	0	10831	942	33	2	3313	2	NXF2B	23	101623766	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	484000	101623766	53646794	4409	8803										
ARMCX5	64860	broad.mit.edu	37	chrX	101858222	101858222	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acagctctgagtcttccgaaGaaccaaaatcaggggagtca	10	10	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101858222G>T	ENST00000604957.1	+	1	3775	c.1153G>T	c.(1153-1155)Gaa>Taa	p.E385*	RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000372742.1_Nonsense_Mutation_p.E385*|ARMCX5_ENST00000246174.2_Nonsense_Mutation_p.E385*|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000537008.1_Nonsense_Mutation_p.E385*|ARMCX5_ENST00000541409.1_Nonsense_Mutation_p.E385*|ARMCX5_ENST00000536530.1_Nonsense_Mutation_p.E385*	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	385							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						GTCTTCCGAAGAACCAAAATC	0.418													5	86					0.000602214	0.000636035	1	1	0	T	101858222	G	T	101858222	4	4	48	1	0	0	0	0	0	1	0	0	961	943	33	2	1155	2	ARMCX5	23	101858222	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	234456	101858222	53412338	4410	8804										
GPRASP1	9737	broad.mit.edu	37	chrX	101911592	101911592	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttctgggatggaaaagaagtCagtgaagaagcaggaccatg	14	5	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101911592C>A	ENST00000537097.1	+	6	3564	c.2751C>A	c.(2749-2751)gtC>gtA	p.V917V	GPRASP1_ENST00000444152.1_Silent_p.V917V|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Silent_p.V917V|GPRASP1_ENST00000415986.1_Silent_p.V917V	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	917	Glu-rich.|OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GAAAAGAAGTCAGTGAAGAAG	0.463													33	92					2.61193e-14	3.39424e-14	1	1	0	A	101911592	C	A	101911592	2	1	48	1	0	0	0	0	0	0	0	1	6762	813	29	2		2	GPRASP1	23	101911592	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	53370	101911592	53358968	4411	8805										
GPRASP1	9737	broad.mit.edu	37	chrX	101912218	101912218	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caggtcagtccaggaaattcGagagcatcttagggccaagg	13	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101912218G>A	ENST00000537097.1	+	6	4190	c.3377G>A	c.(3376-3378)cGa>cAa	p.R1126Q	GPRASP1_ENST00000444152.1_Missense_Mutation_p.R1126Q|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Missense_Mutation_p.R1126Q|GPRASP1_ENST00000415986.1_Missense_Mutation_p.R1126Q	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	1126	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CAGGAAATTCGAGAGCATCTT	0.463													52	76					0	0	1	0	0	A	101912218	G	A	101912218	3	1	48	1	0	0	0	0	1	0	0	0	6762	1058	37	1	3379	1	GPRASP1	23	101912218	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	626	101912218	53358342	4412	8806										
GPRASP2	114928	broad.mit.edu	37	chrX	101970234	101970234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcacaggcagaaggagtgtCccagactaatgccgttgctt	12	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:101970234C>T	ENST00000543253.1	+	5	1356	c.437C>T	c.(436-438)tCc>tTc	p.S146F	GPRASP2_ENST00000535209.1_Missense_Mutation_p.S146F|GPRASP2_ENST00000332262.5_Missense_Mutation_p.S146F	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						GAAGGAGTGTCCCAGACTAAT	0.532													93	156					0	0	1	0	0	T	101970234	C	T	101970234	3	4	48	1	0	0	0	0	1	0	0	0	6763	855	30	3	439	3	GPRASP2	23	101970234	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	58016	101970234	53300326	4413	8807										
BHLHB9	80823	broad.mit.edu	37	chrX	102005204	102005204	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggacagcaatctggattaaaGatactaggacaactgactac	9	8	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:102005204G>T	ENST00000372735.1	+	4	1866	c.1281G>T	c.(1279-1281)aaG>aaT	p.K427N	BHLHB9_ENST00000448867.1_Missense_Mutation_p.K427N|BHLHB9_ENST00000361229.4_Missense_Mutation_p.K427N|BHLHB9_ENST00000457056.1_Missense_Mutation_p.K427N|BHLHB9_ENST00000447531.1_Missense_Mutation_p.K427N			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	427						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTGGATTAAAGATACTAGGAC	0.378													23	60					2.89027e-11	3.58842e-11	1	1	0	T	102005204	G	T	102005204	3	4	48	1	0	0	0	0	1	0	0	0	1419	933	33	2	1283	2	BHLHB9	23	102005204	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	34970	102005204	53265356	4414	8808										
TCEAL5	340543	broad.mit.edu	37	chrX	102529347	102529347	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctcgctttccctcgcattCtgtcttcccctccatgtccg	5	19	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:102529347C>A	ENST00000372680.1	-	3	439	c.145G>T	c.(145-147)Gaa>Taa	p.E49*		NM_001012979.2	NP_001012997.1	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	49	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						ccctcgcattctgtcttcccc	0.512													32	48					1.06801e-11	1.33247e-11	1	1	0	A	102529347	C	A	102529347	4	1	48	1	0	0	0	0	0	1	0	0	15733	922	32	2	479	2	TCEAL5	23	102529347	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	524143	102529347	52741213	4415	8809										
BEX2	84707	broad.mit.edu	37	chrX	102564538	102564538	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagggcataaggcaaaactCatcgtgatggtcatggtgag	13	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:102564538C>A	ENST00000536889.1	-	3	820	c.463G>T	c.(463-465)Gag>Tag	p.E155*	BEX2_ENST00000372674.1_Nonsense_Mutation_p.E123*|BEX2_ENST00000372677.3_Nonsense_Mutation_p.E123*	NM_001168399.1|NM_001168400.1	NP_001161871.1|NP_001161872.1	Q9BXY8	BEX2_HUMAN	brain expressed X-linked 2	123					apoptosis|cell cycle|regulation of apoptosis|regulation of cell cycle	cytoplasm|nucleus				endometrium(1)|lung(1)|ovary(1)	3						AGGCAAAACTCATCGTGATGG	0.483													67	98					1.08241e-25	1.52617e-25	1	1	0	A	102564538	C	A	102564538	4	1	48	1	0	0	0	0	0	1	0	0	1410	835	29	2	23	2	BEX2	23	102564538	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	35191	102564538	52706022	4416	8810										
MORF4L2	9643	broad.mit.edu	37	chrX	102931709	102931709	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccaccatctccgtttccagGagtcttctgcttgttctttc	7	14	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:102931709G>T	ENST00000423833.2	-	3	1472	c.247C>A	c.(247-249)Cct>Act	p.P83T	MORF4L2_ENST00000360458.1_Missense_Mutation_p.P83T|MORF4L2_ENST00000433176.2_Missense_Mutation_p.P83T|MORF4L2_ENST00000441076.2_Missense_Mutation_p.P83T|MORF4L2_ENST00000372620.1_5'UTR|MORF4L2_ENST00000492116.1_5'UTR|MORF4L2_ENST00000422154.2_Missense_Mutation_p.P83T|MORF4L2_ENST00000451301.1_Missense_Mutation_p.P83T			Q15014	MO4L2_HUMAN	mortality factor 4 like 2	83					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)	13						CCGTTTCCAGGAGTCTTCTGC	0.562													43	80					1.34996e-11	1.68274e-11	1	1	0	T	102931709	G	T	102931709	3	4	48	1	0	0	0	0	1	0	0	0	9755	1174	41	2	623	2	MORF4L2	23	102931709	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	367171	102931709	52338851	4417	8811										
TMEM31	203562	broad.mit.edu	37	chrX	102968693	102968693	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atcgattgcctgctctttttGagctttatcctgaatttctt	6	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:102968693G>A	ENST00000319560.6	+	3	465	c.274G>A	c.(274-276)Gag>Aag	p.E92K	GLRA4_ENST00000372617.4_Intron	NM_182541.2	NP_872347.2	Q5JXX7	TMM31_HUMAN	transmembrane protein 31	92						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)	7						TGCTCTTTTTGAGCTTTATCC	0.453													10	101					0	0	1	0	0	A	102968693	G	A	102968693	3	1	48	1	0	0	0	0	1	0	0	0	16214	1291	45	3	280	3	TMEM31	23	102968693	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	36984	102968693	52301867	4418	8812										
PLP1	5354	broad.mit.edu	37	chrX	103040584	103040584	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggccactggattgtgtttCtttggggtggcactgttctg	15	7	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:103040584C>A	ENST00000418604.1	+	3	358	c.78C>A	c.(76-78)ttC>ttA	p.F26L	PLP1_ENST00000303958.2_Missense_Mutation_p.F26L|PLP1_ENST00000361621.2_Missense_Mutation_p.F26L	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	26					cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						GATTGTGTTTCTTTGGGGTGG	0.502													84	157					6.16549e-39	8.89393e-39	1	1	0	A	103040584	C	A	103040584	3	1	48	1	0	0	0	0	1	0	0	0	12151	912	32	2	84	2	PLP1	23	103040584	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	71891	103040584	52229976	4419	8813			3	11		3	3	76	N	G_C	5.9573e-05
PLP1	5354	broad.mit.edu	37	chrX	103040636	103040636	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atgaagccctcactggcacaGaaaagctaattgagacctat	8	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:103040636G>A	ENST00000418604.1	+	3	410	c.130G>A	c.(130-132)Gaa>Aaa	p.E44K	PLP1_ENST00000303958.2_Missense_Mutation_p.E44K|PLP1_ENST00000361621.2_Missense_Mutation_p.E44K	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	44					cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						CACTGGCACAGAAAAGCTAAT	0.483													60	124					0	0	1	0	0	A	103040636	G	A	103040636	3	1	48	1	0	0	0	0	1	0	0	0	12151	943	33	3	136	3	PLP1	23	103040636	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	52	103040636	52229924	4420	8814			3	11		3	3	76	N	G_C	5.9573e-05
PLP1	5354	broad.mit.edu	37	chrX	103040659	103040659	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagctaattgagacctatttCtccaaaaactaccaagacta	4	10	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:103040659C>A	ENST00000418604.1	+	3	433	c.153C>A	c.(151-153)ttC>ttA	p.F51L	PLP1_ENST00000303958.2_Missense_Mutation_p.F51L|PLP1_ENST00000361621.2_Missense_Mutation_p.F51L	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	51			F -> S (in HLD1).		cell death|synaptic transmission	integral to membrane		p.F51L(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						AGACCTATTTCTCCAAAAACT	0.478													58	103					4.17463e-26	5.89501e-26	1	1	0	A	103040659	C	A	103040659	3	1	48	1	0	0	0	0	1	0	0	0	12151	912	32	2	159	2	PLP1	23	103040659	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23	103040659	52229901	4421	8815			3	11		3	3	76	N	G_C	5.9573e-05
FAM199X	139231	broad.mit.edu	37	chrX	103411476	103411476	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctccaaccatgtccgacGaggcctcggccatcacttcc	7	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:103411476G>A	ENST00000493442.1	+	1	176	c.10G>A	c.(10-12)Gag>Aag	p.E4K		NM_207318.3	NP_997201.1	Q6PEV8	F199X_HUMAN	family with sequence similarity 199, X-linked	4										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						CATGTCCGACGAGGCCTCGGC	0.692													10	15					0	0	1	0	0	A	103411476	G	A	103411476	3	1	48	1	0	0	0	0	1	0	0	0	5561	1059	37	1	12	1	FAM199X	23	103411476	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	370817	103411476	51859084	4422	8816										
IL1RAPL2	26280	broad.mit.edu	37	chrX	104478596	104478596	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaggatccgctatttagaaAaatctgaagtcactaaaaga	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:104478596A>C	ENST00000372582.1	+	4	1207	c.451A>C	c.(451-453)Aaa>Caa	p.K151Q	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.K151Q	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	151	Ig-like C2-type 2.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CTATTTAGAAAAATCTGAAGT	0.418													31	59					0	0	1	0	0	C	104478596	A	C	104478596	3	2	48	1	0	0	0	0	1	0	0	0	7705	15	1	4	461	4	IL1RAPL2	23	104478596	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1067120	104478596	50791964	4423	8817										
NRK	203447	broad.mit.edu	37	chrX	105179175	105179175	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttgcagtatacgctggattCgtagaagtacctgaggaatc	11	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:105179175C>T	ENST00000428173.2	+	21	3819	c.3516C>T	c.(3514-3516)ttC>ttT	p.F1172F	NRK_ENST00000243300.9_Silent_p.F1171F			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1171							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						ACGCTGGATTCGTAGAAGTAC	0.373										HNSCC(51;0.14)			28	65					0	0	1	0	0	T	105179175	C	T	105179175	2	4	48	1	0	0	0	0	0	0	0	1	10702	883	31	1		1	NRK	23	105179175	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	700579	105179175	50091385	4424	8818										
NRK	203447	broad.mit.edu	37	chrX	105187975	105187975	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tattgcaattgctttgaaatCatcaattcacctttatgcat	4	8	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:105187975C>A	ENST00000428173.2	+	24	4307	c.4004C>A	c.(4003-4005)tCa>tAa	p.S1335*	NRK_ENST00000243300.9_Nonsense_Mutation_p.S1334*			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1334	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.S1335*(1)|p.S1334*(1)		breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						GCTTTGAAATCATCAATTCAC	0.323										HNSCC(51;0.14)			3	6					0.00909568	0.00935351	1	1	0	A	105187975	C	A	105187975	4	1	48	1	0	0	0	0	0	1	0	0	10702	838	29	2	4095	2	NRK	23	105187975	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	8800	105187975	50082585	4425	8819										
NRK	203447	broad.mit.edu	37	chrX	105190310	105190310	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggttttatattcacaggtaTttccaacacttgatcataag	6	7	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:105190310T>G	ENST00000428173.2	+	26	4513	c.4210T>G	c.(4210-4212)Ttt>Gtt	p.F1404V	NRK_ENST00000243300.9_Missense_Mutation_p.F1403V			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1403	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TTCACAGGTATTTCCAACACT	0.368										HNSCC(51;0.14)			5	20					0	0	1	0	0	G	105190310	T	G	105190310	3	3	48	1	0	0	0	0	1	0	0	0	10702	1493	52	4	4309	4	NRK	23	105190310	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	2335	105190310	50080250	4426	8820										
SERPINA7	6906	broad.mit.edu	37	chrX	105280576	105280576	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttggagaagtcggtagaaaaGacttcagtctcatagagggt	13	5	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:105280576G>T	ENST00000327674.4	-	1	809	c.474C>A	c.(472-474)gtC>gtA	p.V158V	SERPINA7_ENST00000372563.1_Silent_p.V158V			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	158					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	CGGTAGAAAAGACTTCAGTCT	0.438													55	97					1.27102e-15	1.67768e-15	1	1	0	T	105280576	G	T	105280576	2	4	48	1	0	0	0	0	0	0	0	1	14147	929	33	2		2	SERPINA7	23	105280576	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	90266	105280576	49989984	4427	8821										
MUM1L1	139221	broad.mit.edu	37	chrX	105451046	105451046	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaatgtccttccaaaaaattCtccctgaccggatgaaggct	7	11	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:105451046C>A	ENST00000337685.2	+	5	2406	c.1621C>A	c.(1621-1623)Ctc>Atc	p.L541I	MUM1L1_ENST00000357175.2_Missense_Mutation_p.L541I|MUM1L1_ENST00000372552.1_Missense_Mutation_p.L541I	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	541										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCAAAAAATTCTCCCTGACCG	0.473													9	13					1.12685e-05	1.24509e-05	1	1	0	A	105451046	C	A	105451046	3	1	48	1	0	0	0	0	1	0	0	0	10033	913	32	2	1623	2	MUM1L1	23	105451046	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	170470	105451046	49819514	4428	8822										
CXorf57	55086	broad.mit.edu	37	chrX	105876450	105876450	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtggaactgttttcaacatCgcagccagaaatctttgaaa	8	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:105876450C>T	ENST00000372548.4	+	6	1380	c.1271C>T	c.(1270-1272)tCg>tTg	p.S424L	CXorf57_ENST00000372544.2_Missense_Mutation_p.S424L	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	424										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						TTTTCAACATCGCAGCCAGAA	0.318													20	44					0	0	1	0	0	T	105876450	C	T	105876450	3	4	48	1	0	0	0	0	1	0	0	0	4136	893	31	1	1293	1	CXorf57	23	105876450	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	425404	105876450	49394110	4429	8823										
RNF128	79589	broad.mit.edu	37	chrX	106038844	106038844	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggtaaaccatgaagcaaaTtctgtggcagtggatgttat	11	6	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:106038844T>G	ENST00000255499.2	+	7	1438	c.1188T>G	c.(1186-1188)aaT>aaG	p.N396K	RNF128_ENST00000324342.3_Missense_Mutation_p.N370K	NM_194463.1	NP_919445.1	Q8TEB7	RN128_HUMAN	ring finger protein 128, E3 ubiquitin protein ligase	396						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						ATGAAGCAAATTCTGTGGCAG	0.358													23	165					0	0	1	0	0	G	106038844	T	G	106038844	3	3	48	1	0	0	0	0	1	0	0	0	13487	1490	52	4	1624	4	RNF128	23	106038844	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	162394	106038844	49231716	4430	8824										
TBC1D8B	54885	broad.mit.edu	37	chrX	106083350	106083350	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacgtggtgttagtatgtttCgaaccaaaaagactcgagat	11	6	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:106083350C>T	ENST00000357242.5	+	9	1600	c.1426C>T	c.(1426-1428)Cga>Tga	p.R476*	TBC1D8B_ENST00000276175.3_Nonsense_Mutation_p.R470*|TBC1D8B_ENST00000310452.2_Nonsense_Mutation_p.R476*	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	476						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TAGTATGTTTCGAACCAAAAA	0.348													33	67					0	0	1	0	0	T	106083350	C	T	106083350	4	4	48	1	0	0	0	0	0	1	0	0	15685	876	31	1	1460	1	TBC1D8B	23	106083350	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	44506	106083350	49187210	4431	8825										
TBC1D8B	54885	broad.mit.edu	37	chrX	106093368	106093368	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtttctctctcttggtttCtcacactttttattagtgtg	6	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:106093368C>A	ENST00000357242.5	+	12	2125	c.1951C>A	c.(1951-1953)Ctc>Atc	p.L651I	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.L645I	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	651	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CTCTTGGTTTCTCACACTTTT	0.413													28	43					1.33986e-20	1.83757e-20	1	1	0	A	106093368	C	A	106093368	3	1	48	1	0	0	0	0	1	0	0	0	15685	913	32	2	2063	2	TBC1D8B	23	106093368	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	10018	106093368	49177192	4432	8826										
TBC1D8B	54885	broad.mit.edu	37	chrX	106116961	106116961	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acatcatcagccaaaggattCtctggtactgtctgtggttc	9	10	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:106116961C>A	ENST00000357242.5	+	21	3303	c.3129C>A	c.(3127-3129)ttC>ttA	p.F1043L	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.F1037L	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	1043						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CCAAAGGATTCTCTGGTACTG	0.453													35	82					9.8876e-21	1.35804e-20	1	1	0	A	106116961	C	A	106116961	3	1	48	1	0	0	0	0	1	0	0	0	15685	912	32	2	3277	2	TBC1D8B	23	106116961	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	23593	106116961	49153599	4433	8827										
RIPPLY1	92129	broad.mit.edu	37	chrX	106146382	106146382	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctttcactcccatttacttCttgtccagaggagagaaggc	8	12	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:106146382C>A	ENST00000276173.4	-	1	165	c.136G>T	c.(136-138)Gaa>Taa	p.E46*	CLDN2_ENST00000541806.1_Intron|RIPPLY1_ENST00000411805.1_Nonsense_Mutation_p.E46*	NM_138382.2	NP_612391.1	Q0D2K3	RIPP1_HUMAN	ripply transcriptional repressor 1	46					negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus				lung(1)|urinary_tract(1)	2						CCATTTACTTCTTGTCCAGAG	0.527													8	16					1.12685e-05	1.24509e-05	1	1	0	A	106146382	C	A	106146382	4	1	48	1	0	0	0	0	0	1	0	0	13435	922	32	2	335	2	RIPPLY1	23	106146382	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	29421	106146382	49124178	4434	8828										
NUP62CL	54830	broad.mit.edu	37	chrX	106396734	106396734	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctccatgtaaaatacgaatCtataaagagaaatatgaata	5	5	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:106396734C>A	ENST00000372466.4	-	6	597		c.e6-1		NUP62CL_ENST00000372461.3_Splice_Site	NM_017681.2	NP_060151.2	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like						protein transport	nuclear pore	structural constituent of nuclear pore			lung(4)	4						AAATACGAATCTATAAAGAGA	0.254													10	14					0.00829132	0.00855608	1	1	0	A	106396734	C	A	106396734	5	1	48	1	0	0	0	0	0	0	1	0	10816	927	32	2	221	2	NUP62CL	23	106396734	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	250352	106396734	48873826	4435	8829										
TSC22D3	1831	broad.mit.edu	37	chrX	107018442	107018442	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cggctctagcgaatcctgccGcattatgctgttgagcttgt	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107018442G>A	ENST00000372383.4	-	1	575	c.208C>T	c.(208-210)Cgg>Tgg	p.R70W	TSC22D3_ENST00000315660.4_Missense_Mutation_p.R70W|TSC22D3_ENST00000506081.1_Missense_Mutation_p.R70W|TSC22D3_ENST00000372384.2_Missense_Mutation_p.R70W|TSC22D3_ENST00000514426.1_Missense_Mutation_p.R2W	NM_198057.2	NP_932174.1	Q99576	T22D3_HUMAN	TSC22 domain family, member 3	0							sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)|lung(3)	6						GAATCCTGCCGCATTATGCTG	0.562													43	59					0	0	1	0	0	A	107018442	G	A	107018442	3	1	48	1	0	0	0	0	1	0	0	0	16669	1086	38	1	532	1	TSC22D3	23	107018442	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	621708	107018442	48252118	4436	8830										
MID2	11043	broad.mit.edu	37	chrX	107169924	107169924	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgcaattggcattgcctacaAatcagctccaaagaatgaat	7	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107169924A>G	ENST00000262843.6	+	10	2377	c.1829A>G	c.(1828-1830)aAa>aGa	p.K610R	RP6-191P20.4_ENST00000430140.1_RNA|MID2_ENST00000443968.2_Missense_Mutation_p.K580R	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	610	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						ATTGCCTACAAATCAGCTCCA	0.398													36	50					0	0	1	0	0	G	107169924	A	G	107169924	3	3	48	1	0	0	0	0	1	0	0	0	9625	14	1	4	1867	4	MID2	23	107169924	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	151482	107169924	48100636	4437	8831										
TEX13B	0	broad.mit.edu	37	chrX	107224489	107224489	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgtggacccaagcccagaGaagacagacatggctgtttg	12	10	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107224489G>T	ENST00000302917.1	-	3	852	c.760C>A	c.(760-762)Ctc>Atc	p.L254I		NM_031273.2	NP_112563.1	Q9BXU2	TX13B_HUMAN	testis expressed 13B	254										breast(1)|endometrium(5)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28						CAAGCCCAGAGAAGACAGACA	0.542													11	226					0.000978159	0.00102903	1	1	0	T	107224489	G	T	107224489	3	4	48	1	0	0	0	0	1	0	0	0	15835	942	33	2	182	2	TEX13B	23	107224489	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	54565	107224489	48046071	4438	8832										
PSMD10	5716	broad.mit.edu	37	chrX	107331316	107331316	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagaagccgcaatatgaagaGgagaccaacctgcctataaa	9	10	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107331316G>T	ENST00000217958.3	-	3	324	c.227C>A	c.(226-228)cCt>cAt	p.P76H	PSMD10_ENST00000372295.1_Intron|PSMD10_ENST00000361815.5_Missense_Mutation_p.P76H|PSMD10_ENST00000340200.5_Missense_Mutation_p.P43H|PSMD10_ENST00000372296.1_Intron	NM_002814.3|NM_170750.2	NP_002805.1|NP_736606.1	O75832	PSD10_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	76	Interaction with RELA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						AATATGAAGAGGAGACCAACC	0.453													7	104					8.12818e-05	8.79784e-05	1	1	0	T	107331316	G	T	107331316	3	4	48	1	0	0	0	0	1	0	0	0	12741	1000	35	5	465	5	PSMD10	23	107331316	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	106827	107331316	47939244	4439	8833										
COL4A6	1288	broad.mit.edu	37	chrX	107420147	107420147	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcagtcctactaggcctggAtttccaggaaggccttttag	10	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107420147A>G	ENST00000394872.2	-	28	2844	c.2613T>C	c.(2611-2613)aaT>aaC	p.N871N	COL4A6_ENST00000545689.1_Silent_p.N870N|COL4A6_ENST00000372216.4_Silent_p.N871N|COL4A6_ENST00000538570.1_Silent_p.N870N|COL4A6_ENST00000334504.7_Silent_p.N870N			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	871	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						CTAGGCCTGGATTTCCAGGAA	0.527									Alport syndrome with Diffuse Leiomyomatosis				62	104					0	0	1	0	0	G	107420147	A	G	107420147	2	3	48	1	0	0	0	0	0	0	0	1	3718	330	12	4		4	COL4A6	23	107420147	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	88831	107420147	47850413	4440	8834										
COL4A5	1287	broad.mit.edu	37	chrX	107863490	107863490	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgatattgtattaactaggTttacatggaataccaggaga	9	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107863490T>C	ENST00000328300.6	+	31	2755	c.2509_splice	c.e31-1	p.G837_splice	COL4A5_ENST00000361603.2_Splice_Site_p.G837_splice	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	837	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						ATTAACTAGGTTTACATGGAA	0.423									Alport syndrome with Diffuse Leiomyomatosis				23	50					0	0	1	0	0	C	107863490	T	C	107863490	5	2	48	1	0	0	0	0	0	0	1	0	3717	1739	60	4	2633	4	COL4A5	23	107863490	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	443343	107863490	47407070	4441	8835										
COL4A5	1287	broad.mit.edu	37	chrX	107869523	107869523	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gattacctggacagaaaggcGacaaaggtgatcctggtatt	12	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107869523G>A	ENST00000328300.6	+	36	3434	c.3190G>A	c.(3190-3192)Gac>Aac	p.D1064N	COL4A5_ENST00000361603.2_Missense_Mutation_p.D1064N	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1064	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						ACAGAAAGGCGACAAAGGTGA	0.488									Alport syndrome with Diffuse Leiomyomatosis				22	57					0	0	1	0	0	A	107869523	G	A	107869523	3	1	48	1	0	0	0	0	1	0	0	0	3717	1058	37	1	3332	1	COL4A5	23	107869523	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	6033	107869523	47401037	4442	8836										
COL4A5	1287	broad.mit.edu	37	chrX	107936062	107936062	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtttgcaactttgcttcaaGaaatgactattcttactggc	7	8	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:107936062G>T	ENST00000328300.6	+	50	4857	c.4613G>T	c.(4612-4614)aGa>aTa	p.R1538I	COL4A5_ENST00000361603.2_Missense_Mutation_p.R1532I	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1532	Collagen IV NC1.		W -> S (in APSX; adult type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TTTGCTTCAAGAAATGACTAT	0.483									Alport syndrome with Diffuse Leiomyomatosis				32	50					9.65021e-13	1.22324e-12	1	1	0	T	107936062	G	T	107936062	3	4	48	1	0	0	0	0	1	0	0	0	3717	942	33	2	4796	2	COL4A5	23	107936062	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	66539	107936062	47334498	4443	8837										
ACSL4	2182	broad.mit.edu	37	chrX	108902619	108902619	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcgaatttctttcagtatttCagcttccatagcaggattat	6	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:108902619C>A	ENST00000340800.2	-	16	2446	c.1942G>T	c.(1942-1944)Gaa>Taa	p.E648*	ACSL4_ENST00000348502.6_Nonsense_Mutation_p.E607*|ACSL4_ENST00000469796.2_Nonsense_Mutation_p.E648*	NM_022977.2	NP_075266.1	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	648					fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)	22					Icosapent(DB00159)|Troglitazone(DB00197)	TTCAGTATTTCAGCTTCCATA	0.383													27	71					6.32553e-13	8.04352e-13	1	1	0	A	108902619	C	A	108902619	4	1	48	1	0	0	0	0	0	1	0	0	179	835	29	2	201	2	ACSL4	23	108902619	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	966557	108902619	46367941	4444	8838										
ACSL4	2182	broad.mit.edu	37	chrX	108926385	108926385	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttcttaaaaacttttccatTtggctgcatttcattttctt	3	9	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:108926385T>G	ENST00000340800.2	-	4	835	c.331A>C	c.(331-333)Aat>Cat	p.N111H	ACSL4_ENST00000348502.6_Missense_Mutation_p.N70H|ACSL4_ENST00000469796.2_Missense_Mutation_p.N111H	NM_022977.2	NP_075266.1	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	111					fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)	22					Icosapent(DB00159)|Troglitazone(DB00197)	ACTTTTCCATTTGGCTGCATT	0.348													10	53					0	0	1	0	0	G	108926385	T	G	108926385	3	3	48	1	0	0	0	0	1	0	0	0	179	1841	64	4	1860	4	ACSL4	23	108926385	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23766	108926385	46344175	4445	8839										
TMEM164	84187	broad.mit.edu	37	chrX	109414704	109414704	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggctcttctctcaactggcCtcatgttcttttatcacttc	6	13	6	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:109414704C>A	ENST00000372073.1	+	6	979	c.643C>A	c.(643-645)Ctc>Atc	p.L215I	TMEM164_ENST00000372072.3_Missense_Mutation_p.L66I|TMEM164_ENST00000372068.2_Missense_Mutation_p.L215I|TMEM164_ENST00000464177.1_3'UTR|TMEM164_ENST00000288381.4_Missense_Mutation_p.L176I			Q5U3C3	TM164_HUMAN	transmembrane protein 164	215						integral to membrane				cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|skin(1)	14						CTCAACTGGCCTCATGTTCTT	0.507													34	371					1.62565e-12	2.05093e-12	1	1	0	A	109414704	C	A	109414704	3	1	48	1	0	0	0	0	1	0	0	0	16138	681	24	5	661	5	TMEM164	23	109414704	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	488319	109414704	45855856	4446	8840										
RGAG1	57529	broad.mit.edu	37	chrX	109694334	109694334	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtagcaccagattctgcagaGatatcaccattggcaatgcc	9	11	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:109694334G>A	ENST00000465301.2	+	3	735	c.489G>A	c.(487-489)gaG>gaA	p.E163E	RGAG1_ENST00000540313.1_Silent_p.E163E	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	163										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						ATTCTGCAGAGATATCACCAT	0.478													9	87					0	0	1	0	0	A	109694334	G	A	109694334	2	1	48	1	0	0	0	0	0	0	0	1	13325	933	33	3		3	RGAG1	23	109694334	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	279630	109694334	45576226	4447	8841										
RGAG1	57529	broad.mit.edu	37	chrX	109695280	109695280	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctggagcaatgcccacaGgctctatgaaagccgtggca	11	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:109695280G>T	ENST00000465301.2	+	3	1681	c.1435G>T	c.(1435-1437)Ggc>Tgc	p.G479C	RGAG1_ENST00000540313.1_Missense_Mutation_p.G479C	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	479										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						AATGCCCACAGGCTCTATGAA	0.507													15	311					2.61681e-11	3.25035e-11	1	1	0	T	109695280	G	T	109695280	3	4	48	1	0	0	0	0	1	0	0	0	13325	1000	35	5	1437	5	RGAG1	23	109695280	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	946	109695280	45575280	4448	8842										
CAPN6	827	broad.mit.edu	37	chrX	110496278	110496278	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gagcattccaaaactcattcAtggaagtggagaaagagaag	11	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:110496278A>G	ENST00000324068.1	-	4	631	c.464T>C	c.(463-465)aTg>aCg	p.M155T	CAPN6_ENST00000541758.1_5'UTR	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	155	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						AAACTCATTCATGGAAGTGGA	0.433													28	45					0	0	1	0	0	G	110496278	A	G	110496278	3	3	48	1	0	0	0	0	1	0	0	0	2648	217	8	4	1501	4	CAPN6	23	110496278	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	800998	110496278	44774282	4449	8843										
ALG13	79868	broad.mit.edu	37	chrX	110978304	110978304	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcaggacagaaagtcatgttCtatgtctcctcaggacacag	9	10	5	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:110978304C>A	ENST00000394780.3	+	22	2495	c.2483C>A	c.(2482-2484)tCt>tAt	p.S828Y	ALG13_ENST00000470971.1_3'UTR|ALG13_ENST00000251943.4_Missense_Mutation_p.S724Y	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	828					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						AAGTCATGTTCTATGTCTCCT	0.323													15	28					1.15088e-07	1.32965e-07	1	1	0	A	110978304	C	A	110978304	3	1	48	1	0	0	0	0	1	0	0	0	512	913	32	2	2711	2	ALG13	23	110978304	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	482026	110978304	44292256	4450	8844										
ALG13	79868	broad.mit.edu	37	chrX	111003114	111003114	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgttcccccctggcatccaGttggtacagcatatggtggt	12	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:111003114G>T	ENST00000394780.3	+	27	3313	c.3301G>T	c.(3301-3303)Gtt>Ttt	p.V1101F	ALG13_ENST00000470971.1_3'UTR|ALG13_ENST00000251943.4_Missense_Mutation_p.V918F	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	1101					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						CTGGCATCCAGTTGGTACAGC	0.498													17	26					2.48551e-13	3.17925e-13	1	1	0	T	111003114	G	T	111003114	3	4	48	1	0	0	0	0	1	0	0	0	512	1029	36	5	3549	5	ALG13	23	111003114	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	24810	111003114	44267446	4451	8845										
TRPC5	7224	broad.mit.edu	37	chrX	111019750	111019750	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gccctggacttcacctaattCtacctcactgaggttaattt	6	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:111019750C>A	ENST00000262839.2	-	11	3631	c.2713G>T	c.(2713-2715)Gaa>Taa	p.E905*		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	905					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TCACCTAATTCTACCTCACTG	0.483													6	51					3.59834e-05	3.93264e-05	1	1	0	A	111019750	C	A	111019750	4	1	48	1	0	0	0	0	0	1	0	0	16642	922	32	2	212	2	TRPC5	23	111019750	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	16636	111019750	44250810	4452	8846										
TRPC5	7224	broad.mit.edu	37	chrX	111019917	111019917	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgaccattaaatttggagAataggagacccagtttcttg	9	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:111019917A>T	ENST00000262839.2	-	11	3464	c.2546T>A	c.(2545-2547)tTc>tAc	p.F849Y		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	849					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAATTTGGAGAATAGGAGACC	0.458													47	81					0	0	1	0	0	T	111019917	A	T	111019917	3	4	48	1	0	0	0	0	1	0	0	0	16642	246	9	4	379	4	TRPC5	23	111019917	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	167	111019917	44250643	4453	8847										
TRPC5	7224	broad.mit.edu	37	chrX	111078180	111078180	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gataggagttgttcatcataGcaatcagcatgttcagcagc	10	8	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:111078180G>T	ENST00000262839.2	-	7	2783	c.1865C>A	c.(1864-1866)gCt>gAt	p.A622D		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	622					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GTTCATCATAGCAATCAGCAT	0.448													85	163					7.14593e-30	1.01984e-29	1	1	0	T	111078180	G	T	111078180	3	4	48	1	0	0	0	0	1	0	0	0	16642	971	34	5	1076	5	TRPC5	23	111078180	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	58263	111078180	44192380	4454	8848										
LHFPL1	340596	broad.mit.edu	37	chrX	111874817	111874817	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacagtaataggcccagccaAgccgacaggtacctgtgaga	11	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:111874817A>C	ENST00000371968.3	-	4	733	c.494T>G	c.(493-495)cTt>cGt	p.L165R	LHFPL1_ENST00000478229.1_5'UTR|LHFPL1_ENST00000536453.1_Missense_Mutation_p.L132R	NM_178175.3	NP_835469.1	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1	165						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)	13						GGCCCAGCCAAGCCGACAGGT	0.473													17	49					0	0	1	0	0	C	111874817	A	C	111874817	3	2	48	1	0	0	0	0	1	0	0	0	8803	72	3	4	172	4	LHFPL1	23	111874817	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	796637	111874817	43395743	4455	8849										
AMOT	154796	broad.mit.edu	37	chrX	112022529	112022529	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcagcagctgaggcaacagaGgcagcagctggaatctgacc	14	11	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:112022529G>A	ENST00000371959.3	-	10	2852	c.2853C>T	c.(2851-2853)gcC>gcT	p.A951A	AMOT_ENST00000371962.1_Silent_p.A719A|AMOT_ENST00000524145.1_Silent_p.A951A|AMOT_ENST00000304758.1_Silent_p.A542A	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	951					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						aggcaacagaggcagcagctg	0.637													3	12					0	0	1	0	0	A	112022529	G	A	112022529	2	1	48	1	0	0	0	0	0	0	0	1	578	987	35	3		3	AMOT	23	112022529	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	147712	112022529	43248031	4456	8850										
SLC6A14	11254	broad.mit.edu	37	chrX	115574871	115574871	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagatcatccaaatgaataAaagctgggtagacatcaaca	8	7	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:115574871A>C	ENST00000371900.4	+	5	657	c.569A>C	c.(568-570)aAa>aCa	p.K190T		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	190					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	CAAATGAATAAAAGCTGGGTA	0.363													7	28					0	0	1	0	0	C	115574871	A	C	115574871	3	2	48	1	0	0	0	0	1	0	0	0	14731	14	1	4	587	4	SLC6A14	23	115574871	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	3552342	115574871	39695689	4457	8851										
SLC6A14	11254	broad.mit.edu	37	chrX	115590115	115590115	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttagtggcagcagaaaaccGgaatgagatctcattgaaaa	11	6	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:115590115G>T	ENST00000371900.4	+	14	2011	c.1923G>T	c.(1921-1923)ccG>ccT	p.P641P		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	641					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	GCAGAAAACCGGAATGAGATC	0.343													35	67					4.34311e-12	5.44389e-12	1	1	0	T	115590115	G	T	115590115	2	4	48	1	0	0	0	0	0	0	0	1	14731	1103	39	5		5	SLC6A14	23	115590115	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	15244	115590115	39680445	4458	8852										
KLHL13	90293	broad.mit.edu	37	chrX	117043459	117043459	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtccgccaaccacatagaGaaaatttccaatgacggcga	8	12	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:117043459G>T	ENST00000371876.1	-	4	3439	c.1018C>A	c.(1018-1020)Ctc>Atc	p.L340I	KLHL13_ENST00000262820.3_Missense_Mutation_p.L391I|KLHL13_ENST00000541812.1_Missense_Mutation_p.L375I|KLHL13_ENST00000371878.1_Missense_Mutation_p.L340I|KLHL13_ENST00000539496.1_Missense_Mutation_p.L394I|KLHL13_ENST00000545703.1_Missense_Mutation_p.L349I|KLHL13_ENST00000371882.1_Missense_Mutation_p.L340I|KLHL13_ENST00000469946.1_Missense_Mutation_p.L340I|KLHL13_ENST00000540167.1_Missense_Mutation_p.L375I			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	391					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						ACCACATAGAGAAAATTTCCA	0.443													28	52					9.39395e-14	1.21013e-13	1	1	0	T	117043459	G	T	117043459	3	4	48	1	0	0	0	0	1	0	0	0	8411	942	33	2	808	2	KLHL13	23	117043459	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1453344	117043459	38227101	4459	8853										
WDR44	54521	broad.mit.edu	37	chrX	117527097	117527097	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatagtggctagtacaaagaAgcctgttccagcacgcccac	9	12	0	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:117527097A>C	ENST00000254029.3	+	4	1084	c.689A>C	c.(688-690)aAg>aCg	p.K230T	WDR44_ENST00000371822.5_Missense_Mutation_p.K205T|WDR44_ENST00000371825.3_Missense_Mutation_p.K230T|WDR44_ENST00000493448.1_3'UTR	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	230	Pro-rich.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						AGTACAAAGAAGCCTGTTCCA	0.517													65	123					0	0	1	0	0	C	117527097	A	C	117527097	3	2	48	1	0	0	0	0	1	0	0	0	17355	72	3	4	703	4	WDR44	23	117527097	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	483638	117527097	37743463	4460	8854										
DOCK11	139818	broad.mit.edu	37	chrX	117817047	117817047	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatattcatccacaggaaatTtatacaagcatgcagcattg	7	8	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:117817047T>G	ENST00000276204.6	+	52	6043	c.5969T>G	c.(5968-5970)tTt>tGt	p.F1990C	DOCK11_ENST00000276202.7_Missense_Mutation_p.F1990C			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1990	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CACAGGAAATTTATACAAGCA	0.363													53	74					0	0	1	0	0	G	117817047	T	G	117817047	3	3	48	1	0	0	0	0	1	0	0	0	4713	1841	64	4	6175	4	DOCK11	23	117817047	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	289950	117817047	37453513	4461	8855										
IL13RA1	3597	broad.mit.edu	37	chrX	117875003	117875003	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcagccacctgtgacaaatTtgagtgtctctgttgaaaac	8	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:117875003T>G	ENST00000371666.3	+	2	179	c.112T>G	c.(112-114)Ttg>Gtg	p.L38V	IL13RA1_ENST00000371642.1_Missense_Mutation_p.L38V	NM_001560.2	NP_001551.1	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1	38						interleukin-13 receptor complex	cytokine receptor activity	p.L38V(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	12						TGTGACAAATTTGAGTGTCTC	0.373													31	52					0	0	1	0	0	G	117875003	T	G	117875003	3	3	48	1	0	0	0	0	1	0	0	0	7672	1838	64	4	118	4	IL13RA1	23	117875003	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	57956	117875003	37395557	4462	8856										
LONRF3	79836	broad.mit.edu	37	chrX	118112414	118112414	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	atagcatgtaagctccgcccGatgggttttaaggtgagtgt	13	7	0	1	rs140224937	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:118112414G>A	ENST00000422289.2	+	0	721				LONRF3_ENST00000304778.7_Silent_p.P308P|LONRF3_ENST00000472173.1_3'UTR|LONRF3_ENST00000371628.3_Silent_p.P308P|LONRF3_ENST00000365713.2_Silent_p.P308P			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3						proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						AGCTCCGCCCGATGGGTTTTA	0.498													23	54					0	0	1	0	0	A	118112414	G	A	118112414	1	1	48	1	0	0	0	0	0	0	0	0	8940	1045	37	1		1	LONRF3	23	118112414	Translation_Start_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	237411	118112414	37158146	4463	8857										
SLC25A5	292	broad.mit.edu	37	chrX	118603829	118603829	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgggtggtgtggacaagaGaacccagttttggctctact	13	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:118603829G>T	ENST00000317881.8	+	2	433	c.317G>T	c.(316-318)aGa>aTa	p.R106I	SLC25A5_ENST00000460013.1_3'UTR	NM_001152.4	NP_001143.2	P05141	ADT2_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	106					chromosome segregation|energy reserve metabolic process|interspecies interaction between organisms|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane|mitochondrial nucleoid|MMXD complex	adenine transmembrane transporter activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(2)	12					Clodronate(DB00720)	GTGGACAAGAGAACCCAGTTT	0.517													51	142					1.95508e-11	2.43271e-11	1	1	0	T	118603829	G	T	118603829	3	4	48	1	0	0	0	0	1	0	0	0	14566	942	33	2	323	2	SLC25A5	23	118603829	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	491415	118603829	36666731	4464	8858										
NKRF	55922	broad.mit.edu	37	chrX	118724345	118724345	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgttaaggataccaattgcaTcatttgcattttctgtaatg	7	6	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:118724345T>C	ENST00000371527.1	-	2	1695	c.1043A>G	c.(1042-1044)gAt>gGt	p.D348G	NKRF_ENST00000542113.1_Missense_Mutation_p.D363G|NKRF_ENST00000487600.1_Intron|NKRF_ENST00000304449.5_Missense_Mutation_p.D348G	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	348					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						ACCAATTGCATCATTTGCATT	0.408													25	89					0	0	1	0	0	C	118724345	T	C	118724345	3	2	48	1	0	0	0	0	1	0	0	0	10493	1435	50	4	1033	4	NKRF	23	118724345	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	120516	118724345	36546215	4465	8859										
NKRF	55922	broad.mit.edu	37	chrX	118724928	118724928	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtgatggtgaaggctcagGagttgactgagagtttgcct	15	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:118724928G>T	ENST00000371527.1	-	2	1112	c.460C>A	c.(460-462)Cct>Act	p.P154T	NKRF_ENST00000542113.1_Missense_Mutation_p.P169T|NKRF_ENST00000487600.1_Intron|NKRF_ENST00000304449.5_Missense_Mutation_p.P154T	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	154	Active repression domain.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding	p.P154S(1)		breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						GAAGGCTCAGGAGTTGACTGA	0.463													30	74					2.90539e-05	3.18585e-05	1	1	0	T	118724928	G	T	118724928	3	4	48	1	0	0	0	0	1	0	0	0	10493	1174	41	2	1616	2	NKRF	23	118724928	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	583	118724928	36545632	4466	8860										
SEPT6	23157	broad.mit.edu	37	chrX	118763353	118763353	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctgggactggagcagctcaGccgccgtctttctttgcttg	12	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:118763353G>A	ENST00000394610.1	-	9	1472	c.1208C>T	c.(1207-1209)gCt>gTt	p.A403V	SEPT6_ENST00000394616.4_Missense_Mutation_p.A345V|SEPT6_ENST00000467310.1_5'UTR|SEPT6_ENST00000394617.2_Missense_Mutation_p.A433V|SEPT6_ENST00000489216.1_Missense_Mutation_p.A403V|SEPT6_ENST00000360156.7_Missense_Mutation_p.A403V|SEPT6_ENST00000343984.5_Missense_Mutation_p.A403V|SEPT6_ENST00000354416.3_Missense_Mutation_p.A403V|SEPT6_ENST00000354228.4_Missense_Mutation_p.A403V	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	403					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						GAGCAGCTCAGCCGCCGTCTT	0.512			T	MLL	AML								49	90					0	0	1	0	0	A	118763353	G	A	118763353	3	1	48	1	0	0	0	0	1	0	0	0	14121	971	34	3	126	3	SEPT6	23	118763353	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	38425	118763353	36507207	4467	8861										
UPF3B	0	broad.mit.edu	37	chrX	118979216	118979216	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttagtcttcttttttgcagcTttttgaaaaggtgcaaattc	7	6	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:118979216T>A	ENST00000276201.2	-	4	483	c.414A>T	c.(412-414)aaA>aaT	p.K138N	UPF3B_ENST00000345865.2_Missense_Mutation_p.K138N|UPF3B_ENST00000478840.1_5'UTR	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	138	Necessary for interaction with UPF2.|Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						TTTTTGCAGCTTTTTGAAAAG	0.343													25	38					0	0	1	0	0	A	118979216	T	A	118979216	3	1	48	1	0	0	0	0	1	0	0	0	17065	1606	56	4	1069	4	UPF3B	23	118979216	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	215863	118979216	36291344	4468	8862										
NKAP	79576	broad.mit.edu	37	chrX	119070327	119070327	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttcttatgttttcttttCgatgattttttctttctcct	3	8	4	1	rs10577974		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:119070327C>T	ENST00000371410.3	-	4	772	c.606G>A	c.(604-606)tcG>tcA	p.S202S	NKAP_ENST00000477789.1_5'UTR	NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	202	Lys-rich.|Necessary for interaction with CIR1.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						GTTTTCTTTTCGATGATTTTT	0.348													10	38					0	0	1	0	0	T	119070327	C	T	119070327	2	4	48	1	0	0	0	0	0	0	0	1	10485	871	31	1		1	NKAP	23	119070327	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	91111	119070327	36200233	4469	8863										
LAMP2	0	broad.mit.edu	37	chrX	119565273	119565273	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgccaaggcagctcccaccgCtatgggcacaaggaagttgt	12	12	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:119565273C>T	ENST00000200639.4	-	9	1274	c.1138G>A	c.(1138-1140)Gcg>Acg	p.A380T	LAMP2_ENST00000434600.2_Intron|LAMP2_ENST00000538785.1_Intron			P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2	380					platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				endometrium(4)|large_intestine(2)|lung(5)|ovary(2)|urinary_tract(2)	15						GCTCCCACCGCTATGGGCACA	0.438													76	170					0	0	1	0	0	T	119565273	C	T	119565273	3	4	48	1	0	0	0	0	1	0	0	0	8656	797	28	3	245	3	LAMP2	23	119565273	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	494946	119565273	35705287	4470	8864										
CUL4B	8450	broad.mit.edu	37	chrX	119670796	119670796	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttacctctggtggtaaatGaacttccataggcacatatg	8	9	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:119670796G>T	ENST00000371322.5	-	15	2093	c.2032C>A	c.(2032-2034)Cat>Aat	p.H678N	CUL4B_ENST00000404115.3_Missense_Mutation_p.H696N|CUL4B_ENST00000336592.6_Missense_Mutation_p.H683N	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	696					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GGTGGTAAATGAACTTCCATA	0.353													22	37					2.89027e-11	3.58842e-11	1	1	0	T	119670796	G	T	119670796	3	4	48	1	0	0	0	0	1	0	0	0	4081	1290	45	2	679	2	CUL4B	23	119670796	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	105523	119670796	35599764	4471	8865										
C1GALT1C1	29071	broad.mit.edu	37	chrX	119760240	119760240	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctactacctggttggggtgaTaagtcattgcctctttaata	9	8	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:119760240T>C	ENST00000304661.5	-	2	1020	c.782A>G	c.(781-783)tAt>tGt	p.Y261C	C1GALT1C1_ENST00000371313.2_Missense_Mutation_p.Y261C	NM_001011551.2	NP_001011551.1	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	261						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	11						GTTGGGGTGATAAGTCATTGC	0.383													24	59					0	0	1	0	0	C	119760240	T	C	119760240	3	2	48	1	0	0	0	0	1	0	0	0	1966	1406	49	4	178	4	C1GALT1C1	23	119760240	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	89444	119760240	35510320	4472	8866										
GRIA3	2892	broad.mit.edu	37	chrX	122460031	122460031	+	Silent	SNP	C	C	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aagcgatacttgattgactgCgaagtcgaaaggattaacac							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:122460031C>T	ENST00000264357.5	+	4	955	c.663C>T	c.(661-663)tgC>tgT	p.C221C	GRIA3_ENST00000542149.1_Silent_p.C221C|GRIA3_ENST00000371251.1_Silent_p.C221C|GRIA3_ENST00000541091.1_Silent_p.C205C|GRIA3_ENST00000371256.5_Silent_p.C221C	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	221					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TGATTGACTGCGAAGTCGAAA	0.418													43	61					0	0	1	0	0	T	122460031	C	T	122460031	2	4	48	1	0	0	0	0	0	0	0	1	6809	776	27	1		1	GRIA3	23	122460031	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	2699791	122460031	32810529	4473	8867	27	2								
GRIA3	2892	broad.mit.edu	37	chrX	122460038	122460038	+	Missense_Mutation	SNP	G	G	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acttgattgactgcgaagtcGaaaggattaacacaattttg							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:122460038G>A	ENST00000264357.5	+	4	962	c.670G>A	c.(670-672)Gaa>Aaa	p.E224K	GRIA3_ENST00000542149.1_Missense_Mutation_p.E224K|GRIA3_ENST00000371251.1_Missense_Mutation_p.E224K|GRIA3_ENST00000541091.1_Missense_Mutation_p.E208K|GRIA3_ENST00000371256.5_Missense_Mutation_p.E224K	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	224					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CTGCGAAGTCGAAAGGATTAA	0.418													12	89					0	0	1	0	0	A	122460038	G	A	122460038	3	1	48	1	0	0	0	0	1	0	0	0	6809	1059	37	1	684	1	GRIA3	23	122460038	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7	122460038	32810522	4474	8868	27	2								
GRIA3	2892	broad.mit.edu	37	chrX	122561805	122561805	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tttatagatcactctccgggCgcattgttggaggggtttgg	14	7	2	1	rs137852351		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:122561805C>T	ENST00000264357.5	+	12	2183	c.1891C>T	c.(1891-1893)Cgc>Tgc	p.R631C	GRIA3_ENST00000542149.1_Missense_Mutation_p.R631C|GRIA3_ENST00000371251.1_Missense_Mutation_p.R631C|GRIA3_ENST00000371256.5_Missense_Mutation_p.R631C	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	631			R -> S (in MRX94; homomers have minimal or no current; heteromers have altered desensitization kinetics).		glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.R631C(2)		breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	ACTCTCCGGGCGCATTGTTGG	0.438													15	113					0	0	1	0	0	T	122561805	C	T	122561805	3	4	48	1	0	0	0	0	1	0	0	0	6809	768	27	1	1937	1	GRIA3	23	122561805	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	101767	122561805	32708755	4475	8869										
XIAP	331	broad.mit.edu	37	chrX	123019607	123019607	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagtttaatagattaaaaaCttttgctaattttccaagtg	6	4	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:123019607C>A	ENST00000371199.3	+	2	394	c.95C>A	c.(94-96)aCt>aAt	p.T32N	XIAP_ENST00000355640.3_Missense_Mutation_p.T32N|XIAP_ENST00000434753.3_Missense_Mutation_p.T32N|XIAP_ENST00000468691.1_Intron	NM_001167.3	NP_001158.2	P98170	XIAP_HUMAN	X-linked inhibitor of apoptosis	32					anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)	25						AGATTAAAAACTTTTGCTAAT	0.378									X-linked Lymphoproliferative syndrome				47	81					6.1207e-33	8.77752e-33	1	1	0	A	123019607	C	A	123019607	3	1	48	1	0	0	0	0	1	0	0	0	17487	565	20	5	97	5	XIAP	23	123019607	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	457802	123019607	32250953	4476	8870										
STAG2	10735	broad.mit.edu	37	chrX	123185195	123185195	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgtctatgacccttgacaaaGaatatgatgttgcagtacaa	8	7	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:123185195G>T	ENST00000371160.1	+	13	1437	c.1147G>T	c.(1147-1149)Gaa>Taa	p.E383*	STAG2_ENST00000371157.3_Nonsense_Mutation_p.E383*|STAG2_ENST00000371144.3_Nonsense_Mutation_p.E383*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.E314*|STAG2_ENST00000218089.9_Nonsense_Mutation_p.E383*|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000371145.3_Nonsense_Mutation_p.E383*			Q8N3U4	STAG2_HUMAN	stromal antigen 2	383					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						CCTTGACAAAGAATATGATGT	0.279													13	51					1.05317e-09	1.27574e-09	1	1	0	T	123185195	G	T	123185195	4	4	48	1	0	0	0	0	0	1	0	0	15298	943	33	2	1189	2	STAG2	23	123185195	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	165588	123185195	32085365	4477	8871										
ACTRT1	139741	broad.mit.edu	37	chrX	127185898	127185898	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggctgggttttactccaagCtcccgctcaaagagatgttt	10	10	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:127185898C>T	ENST00000371124.3	-	1	484	c.288G>A	c.(286-288)gaG>gaA	p.E96E		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	96						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TTACTCCAAGCTCCCGCTCAA	0.473													127	218					0	0	1	0	0	T	127185898	C	T	127185898	2	4	48	1	0	0	0	0	0	0	0	1	217	796	28	3		3	ACTRT1	23	127185898	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4000703	127185898	28084662	4478	8872										
SMARCA1	6594	broad.mit.edu	37	chrX	128599822	128599822	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgacataaaacatagtactTtggcatccagggctttcttg	8	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:128599822T>G	ENST00000371122.4	-	22	2945	c.2817_splice	c.e22+1	p.K939_splice	SMARCA1_ENST00000371123.1_Splice_Site_p.K927_splice|SMARCA1_ENST00000371121.3_Splice_Site_p.K927_splice	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	939					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						ACATAGTACTTTGGCATCCAG	0.333													12	82					0	0	1	0	0	G	128599822	T	G	128599822	5	3	48	1	0	0	0	0	0	0	1	0	14821	1855	64	4	360	4	SMARCA1	23	128599822	Splice_Site	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1413924	128599822	26670738	4479	8873										
SMARCA1	6594	broad.mit.edu	37	chrX	128657270	128657270	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtggacggcccgggctgctcGtcctctatgaccacgatagt	13	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:128657270G>A	ENST00000371122.4	-	1	207	c.78C>T	c.(76-78)gaC>gaT	p.D26D	SMARCA1_ENST00000371123.1_Silent_p.D26D|SMARCA1_ENST00000371121.3_Silent_p.D26D	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	26					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						CGGGCTGCTCGTCCTCTATGA	0.687													16	93					0	0	1	0	0	A	128657270	G	A	128657270	2	1	48	1	0	0	0	0	0	0	0	1	14821	1136	40	1		1	SMARCA1	23	128657270	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	57448	128657270	26613290	4480	8874										
OCRL	4952	broad.mit.edu	37	chrX	128696430	128696430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggatcagtgtcgatacattCgtgatattgctacagaaaca	9	7	1	2	rs137853831		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:128696430C>T	ENST00000371113.4	+	11	1174	c.1009C>T	c.(1009-1011)Cgt>Tgt	p.R337C	OCRL_ENST00000357121.5_Missense_Mutation_p.R337C	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	337			R -> C (in OCRL; associated with I-361; dbSNP:rs137853831).|R -> P (in OCRL).		regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						TCGATACATTCGTGATATTGC	0.393													53	103					0	0	1	0	0	T	128696430	C	T	128696430	3	4	48	1	0	0	0	0	1	0	0	0	10870	884	31	1	1051	1	OCRL	23	128696430	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	39160	128696430	26574130	4481	8875										
OCRL	4952	broad.mit.edu	37	chrX	128710410	128710410	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcacctggatcgaggcaaaGattacttcttgactatcagt	8	9	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:128710410G>T	ENST00000371113.4	+	18	2161	c.1996G>T	c.(1996-1998)Gat>Tat	p.D666Y	OCRL_ENST00000357121.5_Missense_Mutation_p.D666Y	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	666					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						TCGAGGCAAAGATTACTTCTT	0.433													6	62					0.00116845	0.00122532	1	1	0	T	128710410	G	T	128710410	3	4	48	1	0	0	0	0	1	0	0	0	10870	942	33	2	2066	2	OCRL	23	128710410	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13980	128710410	26560150	4482	8876										
XPNPEP2	7512	broad.mit.edu	37	chrX	128902444	128902444	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggtctccacccttgccatcCttggctggagtgtctagagg	12	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:128902444C>A	ENST00000371106.3	+	21	2200	c.2008C>A	c.(2008-2010)Ctt>Att	p.L670I		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	670					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						CCTTGCCATCCTTGGCTGGAG	0.612													7	29					0.0293803	0.0299069	1	1	0	A	128902444	C	A	128902444	3	1	48	1	0	0	0	0	1	0	0	0	17502	681	24	5	2090	5	XPNPEP2	23	128902444	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	192034	128902444	26368116	4483	8877										
UTP14A	10813	broad.mit.edu	37	chrX	129053155	129053155	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgttgcttctttaaggcaaGaactcccctggagcaggaaa	10	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129053155G>T	ENST00000394422.3	+	7	570	c.542G>T	c.(541-543)aGa>aTa	p.R181I	RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000371051.5_Missense_Mutation_p.R127I|UTP14A_ENST00000371042.3_Missense_Mutation_p.R13I|UTP14A_ENST00000425117.2_Missense_Mutation_p.R129I	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	181					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						TTTAAGGCAAGAACTCCCCTG	0.438													42	76					3.61848e-18	4.89221e-18	1	1	0	T	129053155	G	T	129053155	3	4	48	1	0	0	0	0	1	0	0	0	17154	942	33	2	568	2	UTP14A	23	129053155	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	150711	129053155	26217405	4484	8878										
BCORL1	63035	broad.mit.edu	37	chrX	129147295	129147295	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggcaactctgggaactggaGtccctgtggaggggaccctg	16	10	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129147295G>T	ENST00000540052.1	+	3	591	c.547G>T	c.(547-549)Gtc>Ttc	p.V183F	BCORL1_ENST00000303743.5_Missense_Mutation_p.V183F|BCORL1_ENST00000359304.2_Missense_Mutation_p.V183F|BCORL1_ENST00000218147.7_Missense_Mutation_p.V183F	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	183					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GGGAACTGGAGTCCCTGTGGA	0.577													14	140					4.3838e-07	4.998e-07	1	1	0	T	129147295	G	T	129147295	3	4	48	1	0	0	0	0	1	0	0	0	1385	1029	36	5	557	5	BCORL1	23	129147295	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	94140	129147295	26123265	4485	8879										
BCORL1	63035	broad.mit.edu	37	chrX	129148945	129148945	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catccctgctgctgaacaaaGaccccaacctgggcctcaac	7	17	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129148945G>T	ENST00000540052.1	+	3	2241	c.2197G>T	c.(2197-2199)Gac>Tac	p.D733Y	BCORL1_ENST00000303743.5_Missense_Mutation_p.D733Y|BCORL1_ENST00000359304.2_Missense_Mutation_p.D733Y|BCORL1_ENST00000218147.7_Missense_Mutation_p.D733Y	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	733					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus		p.D733N(1)		breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GCTGAACAAAGACCCCAACCT	0.597													30	55					1.32181e-22	1.84065e-22	1	1	0	T	129148945	G	T	129148945	3	4	48	1	0	0	0	0	1	0	0	0	1385	942	33	2	2207	2	BCORL1	23	129148945	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1650	129148945	26121615	4486	8880										
BCORL1	63035	broad.mit.edu	37	chrX	129150157	129150157	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcagctccagccacaagccAaggccgtggtccggagttcc	12	15	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129150157A>G	ENST00000540052.1	+	3	3453	c.3409A>G	c.(3409-3411)Aag>Gag	p.K1137E	BCORL1_ENST00000303743.5_Missense_Mutation_p.K1137E|BCORL1_ENST00000359304.2_Missense_Mutation_p.K1137E|BCORL1_ENST00000218147.7_Missense_Mutation_p.K1137E	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1137					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GCCACAAGCCAAGGCCGTGGT	0.587													8	34					0	0	1	0	0	G	129150157	A	G	129150157	3	3	48	1	0	0	0	0	1	0	0	0	1385	131	5	4	3419	4	BCORL1	23	129150157	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	1212	129150157	26120403	4487	8881										
RBMX2	51634	broad.mit.edu	37	chrX	129545332	129545332	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttgcttagatcaaaggaaGaactatccgagtggatcatg	10	7	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129545332G>T	ENST00000305536.6	+	5	378	c.314G>T	c.(313-315)aGa>aTa	p.R105I	RBMX2_ENST00000469953.1_3'UTR	NM_016024.2	NP_057108.2	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	105	RRM.						nucleotide binding|RNA binding			breast(4)|endometrium(2)|large_intestine(1)|liver(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	19						ATCAAAGGAAGAACTATCCGA	0.458													6	97					0.00116845	0.00122532	1	1	0	T	129545332	G	T	129545332	3	4	48	1	0	0	0	0	1	0	0	0	13203	942	33	2	332	2	RBMX2	23	129545332	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	395175	129545332	25725228	4488	8882										
ENOX2	10495	broad.mit.edu	37	chrX	129768979	129768979	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttctttaagattttccaaCattttttccacctgtaactt	2	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129768979C>A	ENST00000338144.3	-	13	1902	c.1485G>T	c.(1483-1485)atG>atT	p.M495I	ENOX2_ENST00000394363.1_Missense_Mutation_p.M466I|ENOX2_ENST00000370935.1_Missense_Mutation_p.M466I|ENOX2_ENST00000370927.1_Missense_Mutation_p.M495I	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	495					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						GATTTTCCAACATTTTTTCCA	0.368													9	20					5.4927e-09	6.54492e-09	1	1	0	A	129768979	C	A	129768979	3	1	48	1	0	0	0	0	1	0	0	0	5155	478	17	5	363	5	ENOX2	23	129768979	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	223647	129768979	25501581	4489	8883										
ENOX2	10495	broad.mit.edu	37	chrX	129843233	129843233	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttacctgcatagcctatttcGtagacccacagccatctaaa	5	13	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:129843233G>A	ENST00000338144.3	-	4	450	c.33C>T	c.(31-33)taC>taT	p.Y11Y	ENOX2_ENST00000394363.1_Intron|ENOX2_ENST00000370935.1_Intron|ENOX2_ENST00000492263.1_5'UTR|ENOX2_ENST00000370927.1_Silent_p.Y11Y	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	11					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						AGCCTATTTCGTAGACCCACA	0.413													28	38					0	0	1	0	0	A	129843233	G	A	129843233	2	1	48	1	0	0	0	0	0	0	0	1	5155	1140	40	1		1	ENOX2	23	129843233	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	74254	129843233	25427327	4490	8884										
IGSF1	3547	broad.mit.edu	37	chrX	130412665	130412665	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agagggttaagttcttccacGgggccagaggaaagttggtc	15	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:130412665G>A	ENST00000370904.1	-	18	2694	c.1784C>T	c.(1783-1785)cCg>cTg	p.P595L	IGSF1_ENST00000361420.3_Missense_Mutation_p.P604L|IGSF1_ENST00000370903.3_Missense_Mutation_p.P609L|IGSF1_ENST00000370910.1_Missense_Mutation_p.P595L			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	604	Ig-like C2-type 6.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GTTCTTCCACGGGGCCAGAGG	0.557													39	100					0	0	1	0	0	A	130412665	G	A	130412665	3	1	48	1	0	0	0	0	1	0	0	0	7639	1116	39	1	2235	1	IGSF1	23	130412665	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	569432	130412665	24857895	4491	8885										
IGSF1	3547	broad.mit.edu	37	chrX	130417108	130417108	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcttgtggtaaaaggacttCtccaagtcttcaaccctcat	6	11	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:130417108C>A	ENST00000370904.1	-	12	1681	c.771G>T	c.(769-771)gaG>gaT	p.E257D	IGSF1_ENST00000361420.3_Missense_Mutation_p.E266D|IGSF1_ENST00000370903.3_Missense_Mutation_p.E266D|IGSF1_ENST00000370910.1_Missense_Mutation_p.E257D			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	266	Ig-like C2-type 3.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						AAAAGGACTTCTCCAAGTCTT	0.428													26	52					1.66031e-10	2.0393e-10	1	1	0	A	130417108	C	A	130417108	3	1	48	1	0	0	0	0	1	0	0	0	7639	912	32	2	3287	2	IGSF1	23	130417108	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	4443	130417108	24853452	4492	8886										
OR13H1	347468	broad.mit.edu	37	chrX	130678387	130678387	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tggccacagcagagtgcctcCtactggctgccatggcctat	11	14	0	1	rs144245032	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:130678387C>A	ENST00000338616.3	+	1	438	c.340C>A	c.(340-342)Cta>Ata	p.L114I		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					AGAGTGCCTCCTACTGGCTGC	0.522													38	83					1.90571e-15	2.51191e-15	1	1	0	A	130678387	C	A	130678387	3	1	48	1	0	0	0	0	1	0	0	0	10990	680	24	5	342	5	OR13H1	23	130678387	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	261279	130678387	24592173	4493	8887										
HS6ST2	90161	broad.mit.edu	37	chrX	132091120	132091120	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggtcatcgcccttgatgtcGaagtctaccttgcgcaggag	12	11	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:132091120G>A	ENST00000370836.2	-	3	1078	c.663C>T	c.(661-663)ttC>ttT	p.F221F	HS6ST2_ENST00000521489.1_Silent_p.F221F|HS6ST2_ENST00000370833.2_Silent_p.F75F|HS6ST2_ENST00000370837.1_Silent_p.F75F	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	221						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					CCTTGATGTCGAAGTCTACCT	0.637													20	32					0	0	1	0	0	A	132091120	G	A	132091120	2	1	48	1	0	0	0	0	0	0	0	1	7411	1049	37	1		1	HS6ST2	23	132091120	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	1412733	132091120	23179440	4494	8888										
GPC4	2239	broad.mit.edu	37	chrX	132437257	132437257	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catcttgctggtcatcactcGaagagccatgatttgacgaa	9	10	3	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:132437257G>A	ENST00000370828.3	-	8	1929	c.1405C>T	c.(1405-1407)Cga>Tga	p.R469*	GPC4_ENST00000535467.1_Nonsense_Mutation_p.R399*	NM_001448.2	NP_001439.2	O75487	GPC4_HUMAN	glypican 4	469					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;0.000127)					GTCATCACTCGAAGAGCCATG	0.453													35	80					0	0	1	0	0	A	132437257	G	A	132437257	4	1	48	1	0	0	0	0	0	1	0	0	6639	1066	37	1	273	1	GPC4	23	132437257	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	346137	132437257	22833303	4495	8889										
PHF6	84295	broad.mit.edu	37	chrX	133527538	133527538	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgttttgctgtagatgtgttCtttgtgccattgtcctggag	12	7	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:133527538C>A	ENST00000332070.3	+	4	450	c.248C>A	c.(247-249)tCt>tAt	p.S83Y	PHF6_ENST00000416404.2_Missense_Mutation_p.S49Y|PHF6_ENST00000370803.3_Missense_Mutation_p.S83Y|PHF6_ENST00000370800.4_Missense_Mutation_p.S83Y|PHF6_ENST00000370799.1_Missense_Mutation_p.S83Y|PHF6_ENST00000394292.1_Missense_Mutation_p.S83Y	NM_032458.2	NP_115834.1	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					TAGATGTGTTCTTTGTGCCAT	0.368			"F, N, Splice, Mis"		ETP ALL								40	60					9.39024e-22	1.29924e-21	1	1	0	A	133527538	C	A	133527538	3	1	48	1	0	0	0	0	1	0	0	0	11885	913	32	2	258	2	PHF6	23	133527538	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1090281	133527538	21743022	4496	8890										
FAM122B	159090	broad.mit.edu	37	chrX	133922766	133922766	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtcagttatcctacctttccGaatcccctggtgggtgaagg	11	11	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:133922766G>A	ENST00000370790.1	-	5	1300	c.372C>T	c.(370-372)ttC>ttT	p.F124F	FAM122B_ENST00000298090.6_Silent_p.F143F|FAM122B_ENST00000486347.1_Silent_p.F124F|FAM122B_ENST00000343004.5_Silent_p.F143F|FAM122B_ENST00000493333.1_5'UTR	NM_001166599.2|NM_145284.5	NP_001160071.1|NP_660327.2	Q7Z309	F122B_HUMAN	family with sequence similarity 122B	124										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|skin(1)	6	Acute lymphoblastic leukemia(192;0.000127)					CTACCTTTCCGAATCCCCTGG	0.398													9	35					0	0	1	0	0	A	133922766	G	A	133922766	2	1	48	1	0	0	0	0	0	0	0	1	5451	1049	37	1		1	FAM122B	23	133922766	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	395228	133922766	21347794	4497	8891										
FAM122C	159091	broad.mit.edu	37	chrX	133988254	133988254	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcatttgttctagtagacaAactttcaactaaatgattca	4	8	4	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:133988254A>G	ENST00000370784.4	+	7	982	c.576A>G	c.(574-576)caA>caG	p.Q192Q	FAM122C_ENST00000370785.3_3'UTR|FAM122C_ENST00000445123.1_3'UTR	NM_001170779.1	NP_001164250.1	Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	192										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					CTAGTAGACAAACTTTCAACT	0.418													8	10					0	0	1	0	0	G	133988254	A	G	133988254	2	3	48	1	0	0	0	0	0	0	0	1	5452	11	1	4		4	FAM122C	23	133988254	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	65488	133988254	21282306	4498	8892										
ZNF75D	7626	broad.mit.edu	37	chrX	134427749	134427749	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgatgcttctgcacccagttCtgggtctccttgggcagaat	11	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134427749C>A	ENST00000370766.3	-	3	3027	c.318G>T	c.(316-318)caG>caT	p.Q106H	ZNF75D_ENST00000370764.1_Missense_Mutation_p.Q106H|ZNF75D_ENST00000494295.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	106	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GCACCCAGTTCTGGGTCTCCT	0.502													36	82					3.6622e-26	5.17531e-26	1	1	0	A	134427749	C	A	134427749	3	1	48	1	0	0	0	0	1	0	0	0	18183	912	32	2	1234	2	ZNF75D	23	134427749	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	439495	134427749	20842811	4499	8893										
ZNF449	203523	broad.mit.edu	37	chrX	134494128	134494128	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cttctctcaggttttgagatCgggatagaaaatgaagaaga	11	5	2	5	rs144200813		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134494128C>T	ENST00000339249.4	+	5	824	c.684C>T	c.(682-684)atC>atT	p.I228I		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	228					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTTGAGATCGGGATAGAAA	0.363													22	36					0	0	1	0	0	T	134494128	C	T	134494128	2	4	48	1	0	0	0	0	0	0	0	1	17976	874	31	1		1	ZNF449	23	134494128	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	66379	134494128	20776432	4500	8894										
ZNF449	203523	broad.mit.edu	37	chrX	134494612	134494612	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tatgtaaaaagcgattcactCggcggtcacatcttataggg	10	8	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134494612C>T	ENST00000339249.4	+	5	1308	c.1168C>T	c.(1168-1170)Cgg>Tgg	p.R390W		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	390					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GCGATTCACTCGGCGGTCACA	0.413													43	80					0	0	1	0	0	T	134494612	C	T	134494612	3	4	48	1	0	0	0	0	1	0	0	0	17976	875	31	1	1182	1	ZNF449	23	134494612	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	484	134494612	20775948	4501	8895										
DDX26B	203522	broad.mit.edu	37	chrX	134713730	134713730	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagatgctactatcattcacGatggccatgaggagaagatg	11	8	2	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134713730G>T	ENST00000370752.4	+	15	2360	c.2026G>T	c.(2026-2028)Gat>Tat	p.D676Y	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	676										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					TATCATTCACGATGGCCATGA	0.428													19	50					4.96729e-08	5.79844e-08	1	1	0	T	134713730	G	T	134713730	3	4	48	1	0	0	0	0	1	0	0	0	4376	1058	37	2	2084	2	DDX26B	23	134713730	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	219118	134713730	20556830	4502	8896										
DDX26B	203522	broad.mit.edu	37	chrX	134714991	134714991	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagaatatgaaagaattttCattttgcttgaagaagtgca	8	4	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134714991C>A	ENST00000370752.4	+	16	2734	c.2400C>A	c.(2398-2400)ttC>ttA	p.F800L	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	800										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGAATTTTCATTTTGCTTG	0.308													5	13					1.23904e-05	1.36503e-05	1	1	0	A	134714991	C	A	134714991	3	1	48	1	0	0	0	0	1	0	0	0	4376	825	29	2	2462	2	DDX26B	23	134714991	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1261	134714991	20555569	4503	8897										
SAGE1	55511	broad.mit.edu	37	chrX	134991921	134991921	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtagctggtattccggccaTgagtaccagggatcagtgta	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134991921T>C	ENST00000535938.1	+	14	1873	c.1706T>C	c.(1705-1707)aTg>aCg	p.M569T	SAGE1_ENST00000324447.3_Missense_Mutation_p.M569T|SAGE1_ENST00000537770.1_Missense_Mutation_p.M193T|SAGE1_ENST00000370709.3_Missense_Mutation_p.M569T	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	569										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					ATTCCGGCCATGAGTACCAGG	0.413													17	114					0	0	1	0	0	C	134991921	T	C	134991921	3	2	48	1	0	0	0	0	1	0	0	0	13860	1464	51	4	1756	4	SAGE1	23	134991921	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	276930	134991921	20278639	4504	8898										
SAGE1	55511	broad.mit.edu	37	chrX	134995041	134995041	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctcagaaaagttaagcaCatgagaaaaagataattgtg	8	5	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:134995041C>T	ENST00000535938.1	+	20	2867	c.2700C>T	c.(2698-2700)caC>caT	p.H900H	SAGE1_ENST00000324447.3_Silent_p.H900H|SAGE1_ENST00000537770.1_Silent_p.H524H|SAGE1_ENST00000370709.3_Silent_p.H900H	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	900										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AAGTTAAGCACATGAGAAAAA	0.378													3	16					0	0	1	0	0	T	134995041	C	T	134995041	2	4	48	1	0	0	0	0	0	0	0	1	13860	477	17	3		3	SAGE1	23	134995041	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3120	134995041	20275519	4505	8899										
SLC9A6	10479	broad.mit.edu	37	chrX	135104832	135104832	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaagtaagattggatcaaatTttcaacacatgatgatgttt	8	4	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135104832T>G	ENST00000370695.4	+	11	1473	c.1438T>G	c.(1438-1440)Ttt>Gtt	p.F480V	SLC9A6_ENST00000370701.1_Missense_Mutation_p.F428V|SLC9A6_ENST00000370698.3_Missense_Mutation_p.F448V	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	448					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TGGATCAAATTTTCAACACAT	0.378													11	33					0	0	1	0	0	G	135104832	T	G	135104832	3	3	48	1	0	0	0	0	1	0	0	0	14772	1841	64	4	1480	4	SLC9A6	23	135104832	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	109791	135104832	20165728	4506	8900										
GPR112	139378	broad.mit.edu	37	chrX	135426790	135426790	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttaaagacactggtagatGagacagctacatttgcagtg	10	7	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135426790G>T	ENST00000394143.1	+	6	1216	c.925G>T	c.(925-927)Gag>Tag	p.E309*	GPR112_ENST00000287534.4_Nonsense_Mutation_p.E246*|GPR112_ENST00000370652.1_Nonsense_Mutation_p.E309*|GPR112_ENST00000412101.1_Nonsense_Mutation_p.E104*|GPR112_ENST00000394141.1_Nonsense_Mutation_p.E104*	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	309					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACTGGTAGATGAGACAGCTAC	0.368													17	66					1.99824e-07	2.29918e-07	1	1	0	T	135426790	G	T	135426790	4	4	48	1	0	0	0	0	0	1	0	0	6668	1291	45	2	935	2	GPR112	23	135426790	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	321958	135426790	19843770	4507	8901										
GPR112	139378	broad.mit.edu	37	chrX	135430316	135430316	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttacagttctctccgacaGgatcactacagccttttctg	6	12	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135430316G>T	ENST00000394143.1	+	6	4742	c.4451G>T	c.(4450-4452)aGg>aTg	p.R1484M	GPR112_ENST00000287534.4_Missense_Mutation_p.R1421M|GPR112_ENST00000370652.1_Missense_Mutation_p.R1484M|GPR112_ENST00000412101.1_Missense_Mutation_p.R1279M|GPR112_ENST00000394141.1_Missense_Mutation_p.R1279M	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1484					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTCTCCGACAGGATCACTACA	0.443													13	114					7.93312e-07	8.98086e-07	1	1	0	T	135430316	G	T	135430316	3	4	48	1	0	0	0	0	1	0	0	0	6668	1000	35	5	4461	5	GPR112	23	135430316	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3526	135430316	19840244	4508	8902										
BRS3	680	broad.mit.edu	37	chrX	135570694	135570694	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cagtgttcacattaacaattCtcagcgctgacaggtgagtt	9	9	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135570694C>A	ENST00000370648.3	+	1	649	c.421C>A	c.(421-423)Ctc>Atc	p.L141I		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	141					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					ATTAACAATTCTCAGCGCTGA	0.428													27	50					6.32553e-13	8.04352e-13	1	1	0	A	135570694	C	A	135570694	3	1	48	1	0	0	0	0	1	0	0	0	1524	913	32	2	423	2	BRS3	23	135570694	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	140378	135570694	19699866	4509	8903										
HTATSF1	27336	broad.mit.edu	37	chrX	135593733	135593733	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agatgacggctctgaaaaagTgttagatgaggaaggctctg	14	5	2	5			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135593733T>C	ENST00000535601.1	+	10	2251	c.1829T>C	c.(1828-1830)gTg>gCg	p.V610A	HTATSF1_ENST00000218364.4_Missense_Mutation_p.V610A	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	610	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					TCTGAAAAAGTGTTAGATGAG	0.373													5	95					0	0	1	0	0	C	135593733	T	C	135593733	3	2	48	1	0	0	0	0	1	0	0	0	7476	1696	59	4	1863	4	HTATSF1	23	135593733	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	23039	135593733	19676827	4510	8904										
CD40LG	959	broad.mit.edu	37	chrX	135741501	135741501	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcaaccaggtgcttcggtgtTtgtcaatgtgactgatccaa	11	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135741501T>G	ENST00000370629.2	+	5	769	c.713T>G	c.(712-714)tTt>tGt	p.F238C	CD40LG_ENST00000370628.2_Missense_Mutation_p.F217C	NM_000074.2	NP_000065.1	P29965	CD40L_HUMAN	CD40 ligand	238					anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|skin(1)|stomach(1)	26	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	GCTTCGGTGTTTGTCAATGTG	0.502									Immune Deficiency with Hyper-IgM				63	125					0	0	1	0	0	G	135741501	T	G	135741501	3	3	48	1	0	0	0	0	1	0	0	0	3038	1841	64	4	731	4	CD40LG	23	135741501	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	147768	135741501	19529059	4511	8905										
ARHGEF6	9459	broad.mit.edu	37	chrX	135757212	135757212	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gcgctggtgcagtaggcttcGatcactttaaggatttgagc	13	8	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135757212G>A	ENST00000250617.6	-	19	3194	c.1989C>T	c.(1987-1989)atC>atT	p.I663I	ARHGEF6_ENST00000535227.1_Silent_p.I536I|ARHGEF6_ENST00000370622.1_Silent_p.I509I|ARHGEF6_ENST00000370620.1_Silent_p.I509I	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	663					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					AGTAGGCTTCGATCACTTTAA	0.413													9	19					0	0	1	0	0	A	135757212	G	A	135757212	2	1	48	1	0	0	0	0	0	0	0	1	907	1048	37	1		1	ARHGEF6	23	135757212	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	15711	135757212	19513348	4512	8906										
ARHGEF6	9459	broad.mit.edu	37	chrX	135764991	135764991	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaaaataacataaggtaccGctcctctttttcctgagagg	8	9	1	2	rs147323188		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135764991G>A	ENST00000250617.6	-	13	2610	c.1405C>T	c.(1405-1407)Cgg>Tgg	p.R469W	ARHGEF6_ENST00000535227.1_Missense_Mutation_p.R342W|ARHGEF6_ENST00000370622.1_Missense_Mutation_p.R315W|ARHGEF6_ENST00000370620.1_Missense_Mutation_p.R315W	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	469	PH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					ATAAGGTACCGCTCCTCTTTT	0.343													13	21					0	0	1	0	0	A	135764991	G	A	135764991	3	1	48	1	0	0	0	0	1	0	0	0	907	1086	38	1	965	1	ARHGEF6	23	135764991	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7779	135764991	19505569	4513	8907										
ARHGEF6	9459	broad.mit.edu	37	chrX	135827455	135827455	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgggtttgtctgagaagtaTtagcagcactaagagaagag	14	4	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135827455T>G	ENST00000250617.6	-	4	1591	c.386A>C	c.(385-387)aAt>aCt	p.N129T	ARHGEF6_ENST00000535227.1_5'UTR|ARHGEF6_ENST00000370622.1_5'UTR|ARHGEF6_ENST00000370620.1_5'UTR	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	129					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					CTGAGAAGTATTAGCAGCACT	0.448													74	121					0	0	1	0	0	G	135827455	T	G	135827455	3	3	48	1	0	0	0	0	1	0	0	0	907	1493	52	4	2020	4	ARHGEF6	23	135827455	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	62464	135827455	19443105	4514	8908										
RBMX	27316	broad.mit.edu	37	chrX	135961190	135961190	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tctcacctttccattcatgtCtctggctgcatccttagcgt	6	14	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:135961190C>A	ENST00000562646.1	-	3	356	c.202G>T	c.(202-204)Gac>Tac	p.D68Y	RBMX_ENST00000570135.1_5'UTR|RBMX_ENST00000320676.7_Missense_Mutation_p.D68Y|RBMX_ENST00000431446.3_Missense_Mutation_p.D68Y|RBMX_ENST00000565438.1_Intron			P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked	68	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|urinary_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					CCATTCATGTCTCTGGCTGCA	0.413													34	75					4.34311e-12	5.44389e-12	1	1	0	A	135961190	C	A	135961190	3	1	48	1	0	0	0	0	1	0	0	0	13202	913	32	2	1056	2	RBMX	23	135961190	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	133735	135961190	19309370	4515	8909										
GPR101	83550	broad.mit.edu	37	chrX	136112733	136112733	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tccgggatgttcactgcctcGacgtcatcctcactgaaatt	8	13	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:136112733G>A	ENST00000298110.1	-	1	1100	c.1101C>T	c.(1099-1101)gtC>gtT	p.V367V		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	367						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					TCACTGCCTCGACGTCATCCT	0.537													47	127					0	0	1	0	0	A	136112733	G	A	136112733	2	1	48	1	0	0	0	0	0	0	0	1	6661	1045	37	1		1	GPR101	23	136112733	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	151543	136112733	19157827	4516	8910										
ATP11C	286410	broad.mit.edu	37	chrX	138880864	138880864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcttctcggtattttttagcGtagctcctttcagcaagaga	8	9	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:138880864G>A	ENST00000370557.1	-	9	1776	c.749C>T	c.(748-750)aCg>aTg	p.T250M	ATP11C_ENST00000327569.3_Missense_Mutation_p.T253M|ATP11C_ENST00000370543.1_Missense_Mutation_p.T253M|ATP11C_ENST00000359686.2_Missense_Mutation_p.T253M|ATP11C_ENST00000361648.2_Missense_Mutation_p.T253M			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	253					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					ATTTTTTAGCGTAGCTCCTTT	0.338													21	39					0	0	1	0	0	A	138880864	G	A	138880864	3	1	48	1	0	0	0	0	1	0	0	0	1120	1145	40	1	2791	1	ATP11C	23	138880864	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2768131	138880864	16389696	4517	8911										
ATP11C	286410	broad.mit.edu	37	chrX	138901568	138901568	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttcaaacagattctttgggaGaaaattccaaagtgtatact	7	6	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:138901568G>T	ENST00000370557.1	-	3	1193	c.166C>A	c.(166-168)Ctc>Atc	p.L56I	ATP11C_ENST00000327569.3_Missense_Mutation_p.L59I|ATP11C_ENST00000370543.1_Missense_Mutation_p.L59I|ATP11C_ENST00000359686.2_Missense_Mutation_p.L59I|ATP11C_ENST00000361648.2_Missense_Mutation_p.L59I			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	59					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					TTCTTTGGGAGAAAATTCCAA	0.323													5	19					0.014758	0.015099	1	1	0	T	138901568	G	T	138901568	3	4	48	1	0	0	0	0	1	0	0	0	1120	942	33	2	3398	2	ATP11C	23	138901568	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	20704	138901568	16368992	4518	8912										
CXorf66	347487	broad.mit.edu	37	chrX	139038459	139038459	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctgtggaccgaatggcttggAtggtgagatttcattttgtg	14	5	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:139038459A>G	ENST00000370540.1	-	3	705	c.682T>C	c.(682-684)Tcc>Ccc	p.S228P		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	228						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						AATGGCTTGGATGGTGAGATT	0.453													70	124					0	0	1	0	0	G	139038459	A	G	139038459	3	3	48	1	0	0	0	0	1	0	0	0	4141	333	12	4	407	4	CXorf66	23	139038459	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	136891	139038459	16232101	4519	8913										
CDR1	1038	broad.mit.edu	37	chrX	139865861	139865861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgtcttccagaaaaatctaCgtcttccaccaaatccaggt	6	12	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:139865861C>T	ENST00000370532.2	-	1	862	c.671G>A	c.(670-672)cGt>cAt	p.R224H		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	224								p.R224H(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				GAAAAATCTACGTCTTCCACC	0.448													75	110					0	0	1	0	0	T	139865861	C	T	139865861	3	4	48	1	0	0	0	0	1	0	0	0	3193	536	19	1	121	1	CDR1	23	139865861	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	827402	139865861	15404699	4520	8914										
MAGEC3	139081	broad.mit.edu	37	chrX	140984575	140984575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcctccacttcctcttcctCtttccactttttattcccct	0	19	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:140984575C>T	ENST00000544766.1	+	5	664	c.137C>T	c.(136-138)tCt>tTt	p.S46F	MAGEC3_ENST00000298296.1_Intron|MAGEC3_ENST00000409007.1_Missense_Mutation_p.S46F|MAGEC3_ENST00000536088.1_Missense_Mutation_p.S46F|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000443323.2_Intron	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	440										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					tcctcttcctctttccacttt	0.512													27	48					0	0	1	0	0	T	140984575	C	T	140984575	3	4	48	1	0	0	0	0	1	0	0	0	9231	913	32	3	1286	3	MAGEC3	23	140984575	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	1118714	140984575	14285985	4521	8915										
MAGEC1	9947	broad.mit.edu	37	chrX	140996502	140996502	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	acctttccatcctcttacaaGgatgctttgaaagatgtgga	8	9	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:140996502G>T	ENST00000285879.4	+	4	3598	c.3312G>T	c.(3310-3312)aaG>aaT	p.K1104N	MAGEC1_ENST00000406005.2_Missense_Mutation_p.K171N	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1104	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTTACAAGGATGCTTTGA	0.463										HNSCC(15;0.026)			62	85					9.10829e-22	1.2621e-21	1	1	0	T	140996502	G	T	140996502	3	4	48	1	0	0	0	0	1	0	0	0	9229	991	35	5	3318	5	MAGEC1	23	140996502	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	11927	140996502	14274058	4522	8916										
MAGEC1	9947	broad.mit.edu	37	chrX	140996562	140996562	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	attgacaccacagatgattcGactgccacagaaagtgcaag	9	10	0	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:140996562G>A	ENST00000285879.4	+	4	3658	c.3372G>A	c.(3370-3372)tcG>tcA	p.S1124S	MAGEC1_ENST00000406005.2_Silent_p.S191S	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1124							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATGATTCGACTGCCACAG	0.483										HNSCC(15;0.026)			32	72					0	0	1	0	0	A	140996562	G	A	140996562	2	1	48	1	0	0	0	0	0	0	0	1	9229	1045	37	1		1	MAGEC1	23	140996562	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	60	140996562	14273998	4523	8917										
MAGEC2	51438	broad.mit.edu	37	chrX	141291545	141291545	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatgctctcggtaagatttgGtatcacaccagagggcacct	10	10	2	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:141291545G>A	ENST00000247452.3	-	3	576	c.229C>T	c.(229-231)Cca>Tca	p.P77S		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	77						cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					GTAAGATTTGGTATCACACCA	0.517										HNSCC(46;0.14)			22	59					0	0	1	0	0	A	141291545	G	A	141291545	3	1	48	1	0	0	0	0	1	0	0	0	9230	1261	44	3	896	3	MAGEC2	23	141291545	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	294983	141291545	13979015	4524	8918										
MAGEC2	51438	broad.mit.edu	37	chrX	141291629	141291629	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaagaagagggggaaaataCtaagtacaaagtggaagagg	15	2	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:141291629C>A	ENST00000247452.3	-	3	492	c.145G>T	c.(145-147)Gta>Tta	p.V49L		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	49	Ser-rich.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGAAAATACTAAGTACAAA	0.517										HNSCC(46;0.14)			65	118					2.19297e-23	3.06666e-23	1	1	0	A	141291629	C	A	141291629	3	1	48	1	0	0	0	0	1	0	0	0	9230	565	20	5	980	5	MAGEC2	23	141291629	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	84	141291629	13978931	4525	8919										
SPANXN1	494118	broad.mit.edu	37	chrX	144337190	144337190	+	Splice_Site	SNP	G	G	T													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctctccctgttttcttaacaGatgcaggagacaccaaacag							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:144337190G>T	ENST00000370493.3	+	2	834		c.e2-1			NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1									p.?(2)		endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCTTAACAGATGCAGGAGA	0.443													22	71					2.37509e-13	3.04217e-13	1	1	0	T	144337190	G	T	144337190	5	4	48	1	0	0	0	0	0	0	1	0	15045	956	33	2	81	2	SPANXN1	23	144337190	Splice_Site	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	3045561	144337190	10933370	4526	8920	28	2								
SPANXN1	494118	broad.mit.edu	37	chrX	144337199	144337199	+	Silent	SNP	G	G	A													0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttttcttaacagatgcaggaGacaccaaacagggacttagc							TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:144337199G>A	ENST00000370493.3	+	2	843	c.84G>A	c.(82-84)gaG>gaA	p.E28E		NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1	28										endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					AGATGCAGGAGACACCAAACA	0.423													24	67					0	0	1	0	0	A	144337199	G	A	144337199	2	1	48	1	0	0	0	0	0	0	0	1	15045	933	33	3		3	SPANXN1	23	144337199	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	9	144337199	10933361	4527	8921	28	2								
SLITRK2	84631	broad.mit.edu	37	chrX	144906076	144906076	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gaaggagacccagtagcctaTtaccgaaacctgcaagagtt	10	10	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:144906076T>G	ENST00000370490.1	+	1	6388	c.2133T>G	c.(2131-2133)taT>taG	p.Y711*	SLITRK2_ENST00000413937.2_Nonsense_Mutation_p.Y711*|SLITRK2_ENST00000447897.2_Nonsense_Mutation_p.Y711*|SLITRK2_ENST00000434188.2_Nonsense_Mutation_p.Y711*|SLITRK2_ENST00000428560.2_Nonsense_Mutation_p.Y711*			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	711						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTAGCCTATTACCGAAACC	0.483													6	189					0	0	1	0	0	G	144906076	T	G	144906076	4	3	48	1	0	0	0	0	0	1	0	0	14796	1500	52	4	2135	4	SLITRK2	23	144906076	Nonsense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	568877	144906076	10364484	4528	8922										
FMR1	2332	broad.mit.edu	37	chrX	147030228	147030228	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agttgactgcaataatgaaaGgagtgtccacactaaaacat	8	7	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:147030228G>T	ENST00000370471.3	+	16	1721	c.1492G>T	c.(1492-1494)Gga>Tga	p.G498*	FMR1_ENST00000370475.4_Missense_Mutation_p.R588M|FMR1_ENST00000370477.1_Intron|FMR1_ENST00000218200.8_Missense_Mutation_p.R567M|FMR1_ENST00000440235.2_Intron|FMR1_ENST00000370470.1_Intron|FMR1_ENST00000439526.2_Intron	NM_001185075.1|NM_001185081.1	NP_001172004.1|NP_001172010.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	608	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					AATAATGAAAGGAGTGTCCAC	0.403									Fragile X syndrome				8	84					0.000157383	0.000169016	1	1	0	T	147030228	G	T	147030228	4	4	48	1	0	0	0	0	0	1	0	0	5992	1001	35	5	1829	5	FMR1	23	147030228	Nonsense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	2124152	147030228	8240332	4529	8923										
AFF2	2334	broad.mit.edu	37	chrX	147924957	147924957	+	Splice_Site	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aaagtcagtgtctttcaaatCgtgagtagttggatctccaa	9	7	4	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:147924957C>A	ENST00000370460.2	+	7	1741	c.1262_splice	c.e7+1	p.S421_splice	AFF2_ENST00000342251.3_Splice_Site_p.S388_splice|AFF2_ENST00000370457.5_Splice_Site_p.S388_splice|AFF2_ENST00000286437.5_Splice_Site_p.S62_splice|AFF2_ENST00000370458.1_Intron	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	421					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTTCAAATCGTGAGTAGTT	0.408													24	43					2.21704e-12	2.79328e-12	1	1	0	A	147924957	C	A	147924957	5	1	48	1	0	0	0	0	0	0	1	0	356	898	31	2	1343	2	AFF2	23	147924957	Splice_Site	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	894729	147924957	7345603	4530	8924										
MAGEA11	4110	broad.mit.edu	37	chrX	148797840	148797840	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agataattgatttggttcatTtattgctccgcaagtatcga	8	6	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:148797840T>G	ENST00000355220.5	+	5	796	c.694T>G	c.(694-696)Tta>Gta	p.L232V	MAGEA11_ENST00000333104.4_Missense_Mutation_p.L203V	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	232	MAGE.					cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TTTGGTTCATTTATTGCTCCG	0.438													47	88					0	0	1	0	0	G	148797840	T	G	148797840	3	3	48	1	0	0	0	0	1	0	0	0	9210	1838	64	4	721	4	MAGEA11	23	148797840	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	872883	148797840	6472720	4531	8925										
MAGEA8	4107	broad.mit.edu	37	chrX	149013420	149013420	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gttagttcgtttcctgctccGcaaatatcaaattaaggagc	8	9	1	0	rs150893284		TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:149013420G>A	ENST00000535454.1	+	4	923	c.374G>A	c.(373-375)cGc>cAc	p.R125H	MAGEA8_ENST00000542674.1_Missense_Mutation_p.R125H|MAGEA8_ENST00000286482.1_Missense_Mutation_p.R125H	NM_001166400.1	NP_001159872.1	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	125	MAGE.									NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGCTCCGCAAATATCAA	0.498													51	110					0	0	1	0	0	A	149013420	G	A	149013420	3	1	48	1	0	0	0	0	1	0	0	0	9218	1087	38	1	376	1	MAGEA8	23	149013420	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	215580	149013420	6257140	4532	8926										
MAMLD1	10046	broad.mit.edu	37	chrX	149638113	149638113	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttaagaggccttgccttgaaGatgtcacccttgcaatgggc	11	10	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:149638113G>T	ENST00000370401.2	+	4	578	c.268G>T	c.(268-270)Gat>Tat	p.D90Y	MAMLD1_ENST00000432680.2_Missense_Mutation_p.D65Y|MAMLD1_ENST00000262858.5_Missense_Mutation_p.D90Y|MAMLD1_ENST00000426613.2_Missense_Mutation_p.D65Y|MAMLD1_ENST00000468306.1_3'UTR			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	90					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					TTGCCTTGAAGATGTCACCCT	0.502													45	99					6.7651e-33	9.6967e-33	1	1	0	T	149638113	G	T	149638113	3	4	48	1	0	0	0	0	1	0	0	0	9257	942	33	2	278	2	MAMLD1	23	149638113	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	624693	149638113	5632447	4533	8927										
MTM1	4534	broad.mit.edu	37	chrX	149764986	149764986	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcgagatggagtcaatcgaGatctcactgaggctgttcct	11	10	2	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:149764986G>T	ENST00000370396.2	+	3	142	c.88G>T	c.(88-90)Gat>Tat	p.D30Y	MTM1_ENST00000413012.2_Missense_Mutation_p.D30Y|MTM1_ENST00000542741.1_5'UTR|MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000543350.1_5'UTR	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	30	GRAM.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCAATCGAGATCTCACTGA	0.428													15	18					0.000566183	0.00059967	1	1	0	T	149764986	G	T	149764986	3	4	48	1	0	0	0	0	1	0	0	0	9984	942	33	2	94	2	MTM1	23	149764986	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	126873	149764986	5505574	4534	8928										
MTMR1	8776	broad.mit.edu	37	chrX	149899985	149899985	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aatatccaaaataaacagtaAttatgagttctgtgacacct	5	7	1	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:149899985A>G	ENST00000445323.2	+	9	906	c.785A>G	c.(784-786)aAt>aGt	p.N262S	MTMR1_ENST00000370390.3_Missense_Mutation_p.N254S|MTMR1_ENST00000451863.2_Missense_Mutation_p.N254S|MTMR1_ENST00000538506.1_Missense_Mutation_p.N141S|MTMR1_ENST00000541925.1_Missense_Mutation_p.N160S|MTMR1_ENST00000542156.1_Missense_Mutation_p.N254S|MTMR1_ENST00000544228.1_Missense_Mutation_p.N254S			Q13613	MTMR1_HUMAN	myotubularin related protein 1	254	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ATAAACAGTAATTATGAGTTC	0.398													31	66					0	0	1	0	0	G	149899985	A	G	149899985	3	3	48	1	0	0	0	0	1	0	0	0	9985	101	4	4	791	4	MTMR1	23	149899985	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	134999	149899985	5370575	4535	8929										
CD99L2	83692	broad.mit.edu	37	chrX	149983348	149983348	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gacttacctcttcctcctatAcccggtttcctgcggccatc	6	17	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:149983348A>G	ENST00000370377.3	-	4	381	c.264T>C	c.(262-264)ggT>ggC	p.G88G	CD99L2_ENST00000346693.4_5'UTR|CD99L2_ENST00000466436.1_Intron|CD99L2_ENST00000437787.2_Silent_p.G88G|CD99L2_ENST00000355149.3_Intron	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	88					cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTCCTATACCCGGTTTCC	0.473													49	97					0	0	1	0	0	G	149983348	A	G	149983348	2	3	48	1	0	0	0	0	0	0	0	1	3073	378	14	4		4	CD99L2	23	149983348	Silent	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	83363	149983348	5287212	4536	8930										
HMGB3	3149	broad.mit.edu	37	chrX	150154631	150154631	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ccagctaagggaggcaagaaGaagaaggatcctaatgctcc	12	9	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:150154631G>A	ENST00000325307.7	+	3	354	c.258G>A	c.(256-258)aaG>aaA	p.K86K	HMGB3_ENST00000448905.2_Silent_p.K86K	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	86					DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding			endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGCAAGAAGAAGAAGGATC	0.408													11	26					0	0	1	0	0	A	150154631	G	A	150154631	2	1	48	1	0	0	0	0	0	0	0	1	7267	933	33	3		3	HMGB3	23	150154631	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	171283	150154631	5115929	4537	8931										
MAGEA4	4103	broad.mit.edu	37	chrX	151093031	151093031	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tcagggtcaatgcaagagttCgcattgcctacccatccctg	9	13	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:151093031C>T	ENST00000370340.3	+	3	1162	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	MAGEA4_ENST00000276344.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000370337.4_Missense_Mutation_p.R299C|MAGEA4_ENST00000360243.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000393920.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000393921.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000370335.1_Missense_Mutation_p.R299C			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	299	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGCAAGAGTTCGCATTGCCTA	0.567													67	142					0	0	1	0	0	T	151093031	C	T	151093031	3	4	48	1	0	0	0	0	1	0	0	0	9215	884	31	1	897	1	MAGEA4	23	151093031	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	938400	151093031	4177529	4538	8932										
GABRA3	2556	broad.mit.edu	37	chrX	151358217	151358217	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcaccttcatctccagggcCtctggcaccttcttgccttc	6	18	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:151358217C>A	ENST00000370314.4	-	9	1366	c.1128G>T	c.(1126-1128)gaG>gaT	p.E376D	GABRA3_ENST00000535043.1_Missense_Mutation_p.E376D|GABRA3_ENST00000497894.1_5'UTR|GABRA3_ENST00000370311.1_Missense_Mutation_p.E376D	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	376					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTCCAGGGCCTCTGGCACCT	0.502													33	46					6.00712e-18	8.10414e-18	1	1	0	A	151358217	C	A	151358217	3	1	48	1	0	0	0	0	1	0	0	0	6196	680	24	5	358	5	GABRA3	23	151358217	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	265186	151358217	3912343	4539	8933										
GABRA3	2556	broad.mit.edu	37	chrX	151424408	151424408	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agtggaaggatcttcatgggGccatcaaatttcagtctttc	10	8	5	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:151424408G>A	ENST00000370314.4	-	5	631	c.393C>T	c.(391-393)ggC>ggT	p.G131G	GABRA3_ENST00000535043.1_Silent_p.G131G|GABRA3_ENST00000370311.1_Silent_p.G131G	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	131					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTTCATGGGGCCATCAAATT	0.428													27	83					0	0	1	0	0	A	151424408	G	A	151424408	2	1	48	1	0	0	0	0	0	0	0	1	6196	1190	42	3		3	GABRA3	23	151424408	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	66191	151424408	3846152	4540	8934										
MAGEA6	4105	broad.mit.edu	37	chrX	151869775	151869775	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gtgatcttcagcaaagcttcCgattccttgcagctggtctt	9	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:151869775C>T	ENST00000329342.5	+	3	690	c.465C>T	c.(463-465)tcC>tcT	p.S155S		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	155	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GCAAAGCTTCCGATTCCTTGC	0.552													46	126					0	0	1	0	0	T	151869775	C	T	151869775	2	4	48	1	0	0	0	0	0	0	0	1	9217	639	23	1		1	MAGEA6	23	151869775	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	445367	151869775	3400785	4541	8935										
MAGEA3	4102	broad.mit.edu	37	chrX	151935896	151935896	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggtgcttggcccctcctcttCttggttgctggagtcctcat	11	13	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:151935896C>A	ENST00000393902.3	-	3	838	c.271G>T	c.(271-273)Gaa>Taa	p.E91*	MAGEA3_ENST00000370278.3_Nonsense_Mutation_p.E91*			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	91										endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTCCTCTTCTTGGTTGCTG	0.567													49	88					7.34454e-26	1.03635e-25	1	1	0	A	151935896	C	A	151935896	4	1	48	1	0	0	0	0	0	1	0	0	9214	922	32	2	677	2	MAGEA3	23	151935896	Nonsense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	66121	151935896	3334664	4542	8936										
PNMA5	114824	broad.mit.edu	37	chrX	152159547	152159547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacgtaagctctccagcaaaCgccgcctcttctccacctca	5	19	4	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:152159547C>T	ENST00000439251.1	-	2	1034	c.596G>A	c.(595-597)cGt>cAt	p.R199H	PNMA5_ENST00000452693.1_Missense_Mutation_p.R199H|PNMA5_ENST00000535214.1_Missense_Mutation_p.R199H|PNMA5_ENST00000361887.5_Missense_Mutation_p.R199H	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	199					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCAGCAAACGCCGCCTCTT	0.557													32	84					0	0	1	0	0	T	152159547	C	T	152159547	3	4	48	1	0	0	0	0	1	0	0	0	12203	536	19	1	754	1	PNMA5	23	152159547	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	223651	152159547	3111013	4543	8937										
PNMA3	29944	broad.mit.edu	37	chrX	152226514	152226514	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctggggttggggcagtacctCtccctgcctctggcaacagt	13	13	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:152226514C>A	ENST00000447306.1	+	2	1438	c.1102C>A	c.(1102-1104)Ctc>Atc	p.L368I	PNMA3_ENST00000370265.4_Missense_Mutation_p.L368I|PNMA3_ENST00000370264.4_Missense_Mutation_p.L368I	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	368					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					GGCAGTACCTCTCCCTGCCTC	0.637													10	60					7.48243e-07	8.49459e-07	1	1	0	A	152226514	C	A	152226514	3	1	48	1	0	0	0	0	1	0	0	0	12202	913	32	2	1104	2	PNMA3	23	152226514	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	66967	152226514	3044046	4544	8938										
MAGEA1	4100	broad.mit.edu	37	chrX	152482977	152482977	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggcctcaagggcttcctcagGcttgcagtgcagactcctct	11	14	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:152482977G>A	ENST00000356661.5	-	3	252	c.34C>T	c.(34-36)Cct>Tct	p.P12S		NM_004988.4	NP_004979.3	P43355	MAGA1_HUMAN	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	12						cytoplasm|plasma membrane				breast(1)|central_nervous_system(7)|kidney(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTTCCTCAGGCTTGCAGTGC	0.627													14	119					0	0	1	0	0	A	152482977	G	A	152482977	3	1	48	1	0	0	0	0	1	0	0	0	9208	1203	42	3	899	3	MAGEA1	23	152482977	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	256463	152482977	2787583	4545	8939										
ATP2B3	492	broad.mit.edu	37	chrX	152845520	152845520	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctccattcacaacttcatgGccacgcccgagtttctgatc	6	16	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:152845520G>A	ENST00000263519.4	+	20	3553	c.3427G>A	c.(3427-3429)Gcc>Acc	p.A1143T	ATP2B3_ENST00000359149.3_3'UTR|ATP2B3_ENST00000370186.1_3'UTR|ATP2B3_ENST00000349466.2_Missense_Mutation_p.A1143T|ATP2B3_ENST00000370181.2_3'UTR	NM_001001344.2	NP_001001344.1	Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	1143					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAACTTCATGGCCACGCCCGA	0.592													92	220					0	0	1	0	0	A	152845520	G	A	152845520	3	1	48	1	0	0	0	0	1	0	0	0	1140	1203	42	3	3663	3	ATP2B3	23	152845520	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	362543	152845520	2425040	4546	8940										
PNCK	139728	broad.mit.edu	37	chrX	152936421	152936421	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tgaacctcttctgggggtctCgctccagaaggtgccggatg	14	11	3	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:152936421C>T	ENST00000393831.2	-	9	1261	c.827G>A	c.(826-828)cGa>cAa	p.R276Q	PNCK_ENST00000340888.3_Missense_Mutation_p.R253Q|PNCK_ENST00000447676.2_Missense_Mutation_p.R336Q|PNCK_ENST00000370145.4_Missense_Mutation_p.R270Q|PNCK_ENST00000370142.1_Missense_Mutation_p.R276Q|PNCK_ENST00000370150.1_Missense_Mutation_p.R253Q	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	253						cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGGGGTCTCGCTCCAGAAG	0.642													40	73					0	0	1	0	0	T	152936421	C	T	152936421	3	4	48	1	0	0	0	0	1	0	0	0	12192	884	31	1	285	1	PNCK	23	152936421	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	90901	152936421	2334139	4547	8941										
SSR4	6748	broad.mit.edu	37	chrX	153063544	153063544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	aggctcagaggaataacgagGacatttccatcatcccgcct	9	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153063544G>A	ENST00000320857.3	+	6	1454	c.370G>A	c.(370-372)Gac>Aac	p.D124N	SSR4_ENST00000370087.1_Missense_Mutation_p.D124N|SSR4_ENST00000370085.3_Missense_Mutation_p.D99N|SSR4_ENST00000460616.1_3'UTR|SSR4_ENST00000370086.3_Missense_Mutation_p.D124N	NM_001204526.1	NP_001191455.1	P51571	SSRD_HUMAN	signal sequence receptor, delta	124					intracellular protein transport	integral to membrane|Sec61 translocon complex	calcium ion binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(2)	4	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GAATAACGAGGACATTTCCAT	0.602													66	151					0	0	1	0	0	A	153063544	G	A	153063544	3	1	48	1	0	0	0	0	1	0	0	0	15248	1174	41	3	388	3	SSR4	23	153063544	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	127123	153063544	2207016	4548	8942										
L1CAM	3897	broad.mit.edu	37	chrX	153135092	153135092	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gatcagggcgccacgctgaaTccggtacttctggtctttgg	13	11	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153135092T>C	ENST00000370060.1	-	11	1339	c.1150A>G	c.(1150-1152)Att>Gtt	p.I384V	L1CAM_ENST00000370057.3_Missense_Mutation_p.I384V|L1CAM_ENST00000370055.1_Missense_Mutation_p.I379V|L1CAM_ENST00000543994.1_Missense_Mutation_p.I386V|L1CAM_ENST00000538883.1_Missense_Mutation_p.I386V|L1CAM_ENST00000361699.4_Missense_Mutation_p.I384V|L1CAM_ENST00000361981.3_Missense_Mutation_p.I379V	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	384	Ig-like C2-type 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACGCTGAATCCGGTACTTC	0.632													3	32					0	0	1	0	0	C	153135092	T	C	153135092	3	2	48	1	0	0	0	0	1	0	0	0	8626	1435	50	4	2699	4	L1CAM	23	153135092	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	71548	153135092	2135468	4549	8943										
NAA10	8260	broad.mit.edu	37	chrX	153195617	153195617	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cctttgctctccaccttgttCtcgatggcacccagcaccac	6	18	2	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153195617C>A	ENST00000464845.1	-	8	849	c.531G>T	c.(529-531)gaG>gaT	p.E177D	NAA10_ENST00000370015.4_3'UTR|NAA10_ENST00000370009.1_Missense_Mutation_p.E162D|NAA10_ENST00000393712.3_3'UTR	NM_001256120.1|NM_003491.3	NP_001243049.1|NP_003482.1	P41227	NAA10_HUMAN	N(alpha)-acetyltransferase 10, NatA catalytic subunit	177					DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(3)|ovary(1)|prostate(1)	10						CCACCTTGTTCTCGATGGCAC	0.627													31	58					3.90053e-15	5.12206e-15	1	1	0	A	153195617	C	A	153195617	3	1	48	1	0	0	0	0	1	0	0	0	10163	912	32	2	180	2	NAA10	23	153195617	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	60525	153195617	2074943	4550	8944										
RENBP	5973	broad.mit.edu	37	chrX	153207461	153207461	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ttgccaccctctgacacattCtccagcacagcttgtccatc	5	17	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153207461C>A	ENST00000393700.3	-	7	791	c.711G>T	c.(709-711)gaG>gaT	p.E237D	RENBP_ENST00000369997.3_Missense_Mutation_p.E223D|RENBP_ENST00000412763.1_Intron	NM_002910.5	NP_002901.2	P51606	RENBP_HUMAN	renin binding protein	237					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	CTGACACATTCTCCAGCACAG	0.627													53	94					4.88482e-21	6.72725e-21	1	1	0	A	153207461	C	A	153207461	3	1	48	1	0	0	0	0	1	0	0	0	13276	912	32	2	592	2	RENBP	23	153207461	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11844	153207461	2063099	4551	8945										
HCFC1	3054	broad.mit.edu	37	chrX	153220472	153220472	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgctggtggttggcgccgacGctcgacatggctgtagtggc	17	11	0	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153220472G>A	ENST00000310441.7	-	17	4344	c.3378C>T	c.(3376-3378)agC>agT	p.S1126S	HCFC1_ENST00000354233.3_Silent_p.S1057S|HCFC1_ENST00000369984.4_Silent_p.S1126S	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1126					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGCGCCGACGCTCGACATGG	0.687													14	30					0	0	1	0	0	A	153220472	G	A	153220472	2	1	48	1	0	0	0	0	0	0	0	1	7031	1078	38	1		1	HCFC1	23	153220472	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	13011	153220472	2050088	4552	8946										
HCFC1	3054	broad.mit.edu	37	chrX	153227718	153227718	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggagactgcgaggaagaggcGccaccccgctgagactgggc	17	12	0	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153227718G>A	ENST00000310441.7	-	5	1718	c.752C>T	c.(751-753)gCg>gTg	p.A251V	HCFC1_ENST00000354233.3_Missense_Mutation_p.A251V|HCFC1_ENST00000461098.1_5'UTR|HCFC1_ENST00000369984.4_Missense_Mutation_p.A251V	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	251					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGAAGAGGCGCCACCCCGCT	0.597													13	20					0	0	1	0	0	A	153227718	G	A	153227718	3	1	48	1	0	0	0	0	1	0	0	0	7031	1087	38	1	5443	1	HCFC1	23	153227718	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	7246	153227718	2042842	4553	8947										
FLNA	0	broad.mit.edu	37	chrX	153581372	153581372	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	gggcagccactgcctacctgCatcgcgggtatcaatgataa	11	12	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153581372C>T	ENST00000422373.1	-	37	6447	c.6199G>A	c.(6199-6201)Gca>Aca	p.A2067T	FLNA_ENST00000360319.4_Missense_Mutation_p.A2067T|FLNA_ENST00000369850.3_Missense_Mutation_p.A2075T|FLNA_ENST00000344736.4_Missense_Mutation_p.A2035T|FLNA_ENST00000369856.3_Missense_Mutation_p.A208T	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2075					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCCTACCTGCATCGCGGGTA	0.602													7	51					0	0	1	0	0	T	153581372	C	T	153581372	3	4	48	1	0	0	0	0	1	0	0	0	5965	710	25	3	1764	3	FLNA	23	153581372	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	353654	153581372	1689188	4554	8948										
FLNA	0	broad.mit.edu	37	chrX	153593318	153593318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ctcggtgcccaccttcacttCgaagggactgcaaatgcgag	11	13	1	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153593318C>T	ENST00000422373.1	-	12	1947	c.1699G>A	c.(1699-1701)Gaa>Aaa	p.E567K	FLNA_ENST00000360319.4_Missense_Mutation_p.E567K|FLNA_ENST00000369850.3_Missense_Mutation_p.E567K|FLNA_ENST00000344736.4_Missense_Mutation_p.E567K	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	567					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCTTCACTTCGAAGGGACTG	0.632													9	171					0	0	1	0	0	T	153593318	C	T	153593318	3	4	48	1	0	0	0	0	1	0	0	0	5965	893	31	1	6392	1	FLNA	23	153593318	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	11946	153593318	1677242	4555	8949										
ATP6AP1	537	broad.mit.edu	37	chrX	153663731	153663731	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tacttcaatgcttcccaggtCacagggcccagcatctactc	7	15	3	0			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153663731C>T	ENST00000369762.2	+	9	1144	c.1083C>T	c.(1081-1083)gtC>gtT	p.V361V		NM_001183.4	NP_001174.2	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1	361					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(5)	14	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTCCCAGGTCACAGGGCCCA	0.612													27	58					0	0	1	0	0	T	153663731	C	T	153663731	2	4	48	1	0	0	0	0	0	0	0	1	1163	813	29	3		3	ATP6AP1	23	153663731	Silent	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	70413	153663731	1606829	4556	8950										
PLXNA3	55558	broad.mit.edu	37	chrX	153692557	153692557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cgggcgtgagctgcgccttcGaggcggcggcggagaacgag	20	11	0	2			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153692557G>A	ENST00000369682.3	+	8	1904	c.1729G>A	c.(1729-1731)Gag>Aag	p.E577K		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	577					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity	p.E577K(1)		breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCGCCTTCGAGGCGGCGGC	0.697													14	22					0	0	1	0	0	A	153692557	G	A	153692557	3	1	48	1	0	0	0	0	1	0	0	0	12168	1059	37	1	1755	1	PLXNA3	23	153692557	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	28826	153692557	1578003	4557	8951										
PLXNA3	55558	broad.mit.edu	37	chrX	153697246	153697246	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	ggccccattgatgccatcacGggcgaggcacgatactccct	11	15	1	1	rs140777906	byFrequency	TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:153697246G>A	ENST00000369682.3	+	25	4543	c.4368G>A	c.(4366-4368)acG>acA	p.T1456T		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1456					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGCCATCACGGGCGAGGCAC	0.617													26	73					0	0	1	0	0	A	153697246	G	A	153697246	2	1	48	1	0	0	0	0	0	0	0	1	12168	1103	39	1		1	PLXNA3	23	153697246	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	4689	153697246	1573314	4558	8952										
DKC1	1736	broad.mit.edu	37	chrX	154004474	154004474	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	catctcagcggaagcgagagAgtgagagtgaaagtgacgag	16	6	1	4			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:154004474A>C	ENST00000369550.5	+	14	1561	c.1351A>C	c.(1351-1353)Agt>Cgt	p.S451R	DKC1_ENST00000475966.1_3'UTR	NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	451	Nuclear and nucleolar localization.				cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAAGCGAGAGAGTGAGAGTGA	0.458									Congenital Dyskeratosis				22	48					0	0	1	0	0	C	154004474	A	C	154004474	3	2	48	1	0	0	0	0	1	0	0	0	4570	304	11	4	1405	4	DKC1	23	154004474	Missense_Mutation	SNP	A	TCGA-ND-A4WC-01A-21D-A28R-08	307228	154004474	1266086	4559	8953										
MPP1	4354	broad.mit.edu	37	chrX	154007592	154007592	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	agcgtactggctgcggatggCctcagagtccttctgcagct	13	12	2	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:154007592C>T	ENST00000413259.3	-	13	1563	c.1171G>A	c.(1171-1173)Gcc>Acc	p.A391T	MPP1_ENST00000369534.3_Missense_Mutation_p.A421T|MPP1_ENST00000393531.1_Missense_Mutation_p.A401T	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	421	Guanylate kinase-like.|Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTGCGGATGGCCTCAGAGTCC	0.527													20	57					0	0	1	0	0	T	154007592	C	T	154007592	3	4	48	1	0	0	0	0	1	0	0	0	9781	739	26	3	143	3	MPP1	23	154007592	Missense_Mutation	SNP	C	TCGA-ND-A4WC-01A-21D-A28R-08	3118	154007592	1262968	4560	8954										
F8	2157	broad.mit.edu	37	chrX	154157019	154157019	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	actgatatggtatcatcataGtcaatttcctcttgatctga	6	8	5	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:154157019G>A	ENST00000360256.4	-	14	5246	c.5046C>T	c.(5044-5046)gaC>gaT	p.D1682D		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1682					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TATCATCATAGTCAATTTCCT	0.413													24	35					0	0	1	0	0	A	154157019	G	A	154157019	2	1	48	1	0	0	0	0	0	0	0	1	5378	1020	36	3		3	F8	23	154157019	Silent	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	149427	154157019	1113541	4561	8955										
F8	2157	broad.mit.edu	37	chrX	154158062	154158062	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	tagtgggagtctgaattgttTcaaagctctcttactacgtt	9	7	3	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:154158062T>C	ENST00000360256.4	-	14	4203	c.4003A>G	c.(4003-4005)Aaa>Gaa	p.K1335E		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1335	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CTGAATTGTTTCAAAGCTCTC	0.398													49	80					0	0	1	0	0	C	154158062	T	C	154158062	3	2	48	1	0	0	0	0	1	0	0	0	5378	1792	62	4	3132	4	F8	23	154158062	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	1043	154158062	1112498	4562	8956										
BRCC3	79184	broad.mit.edu	37	chrX	154319106	154319106	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	caatccatacaggcccaaaaGagttcagagtaagtatgaga	9	8	1	3			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:154319106G>T	ENST00000369462.1	+	7	565	c.540G>T	c.(538-540)aaG>aaT	p.K180N	BRCC3_ENST00000340647.4_Missense_Mutation_p.K181N|MTCP1_ENST00000362018.2_Intron|BRCC3_ENST00000399042.1_Missense_Mutation_p.K180N|BRCC3_ENST00000369459.2_Missense_Mutation_p.K180N|BRCC3_ENST00000330045.7_Missense_Mutation_p.K180N	NM_024332.3	NP_077308.1	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	180					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|skin(1)	22	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGGCCCAAAAGAGTTCAGAGT	0.353													4	13					3.59834e-05	3.93264e-05	1	1	0	T	154319106	G	T	154319106	3	4	48	1	0	0	0	0	1	0	0	0	1502	933	33	2	566	2	BRCC3	23	154319106	Missense_Mutation	SNP	G	TCGA-ND-A4WC-01A-21D-A28R-08	161044	154319106	951454	4563	8957										
TMLHE	55217	broad.mit.edu	37	chrX	154741450	154741450	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0369068541300527	168	1	0.532908939752286	0	0.536176497353889	1.53420512269447e-53	8.74496919935848e-52	0	cacatcctcccataaatggtTtctctgttagttgaaataaa	5	9	1	1			TCGA-ND-A4WC-01A-21D-A28R-08	TCGA-ND-A4WC-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	112e587b-c2ae-4cf2-94c6-9dd3d20e7c17	c1de6b18-0ef6-4116-9c50-3abf60f52e24	g.chrX:154741450T>G	ENST00000334398.3	-	5	787	c.642A>C	c.(640-642)gaA>gaC	p.E214D	TMLHE_ENST00000369439.4_Missense_Mutation_p.E214D|TMLHE-AS1_ENST00000452506.1_RNA	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	214					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	CATAAATGGTTTCTCTGTTAG	0.393													35	71					0	0	1	0	0	G	154741450	T	G	154741450	3	3	48	1	0	0	0	0	1	0	0	0	16291	1838	64	4	779	4	TMLHE	23	154741450	Missense_Mutation	SNP	T	TCGA-ND-A4WC-01A-21D-A28R-08	422344	154741450	529110	4564	8958										
HMGN2	3151	broad.mit.edu	37	chr1	26799107	26799107	+	Frame_Shift_Del	DEL	C	C	-													0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ccgtcgccgccgccaccatgCccaagagaaaggtacgtggc							TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:26799107delC	ENST00000361427.5	+	1	98	c.4delC	c.(4-6)ccfs	p.P2fs		NM_005517.3	NP_005508.1	P05204	HMGN2_HUMAN	high mobility group nucleosomal binding domain 2	2					chromatin organization|regulation of transcription, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding|protein binding			breast(1)|lung(2)	3		all_cancers(24;1.9e-24)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.38e-49)|OV - Ovarian serous cystadenocarcinoma(117;5.38e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.026)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CGCCACCATGCCCAAGAGAAA	0.741													2	4	---	---	---	---						-	26799107	C	-	26799107	7	5	49	1	0	1	0	1	0	0	0	0	7275	739	26	0	6	0	HMGN2	1	26799107	Frame_Shift_Del	DEL	C	TCGA-ND-A4WF-01A-11D-A28R-08		26799107	222451514	1	8959										
FLG	2312	broad.mit.edu	37	chr1	152287054	152287054	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gtttatcatgatgactgtgcTttctgtgcttgtgtcctgat	10	7	2	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:152287054T>C	ENST00000368799.1	-	3	343	c.308A>G	c.(307-309)aAg>aGg	p.K103R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	103					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGACTGTGCTTTCTGTGCTT	0.363									Ichthyosis				11	87					0	0	1	0	0	C	152287054	T	C	152287054	3	2	49	1	0	0	0	0	1	0	0	0	5954	1609	56	4	11881	4	FLG	1	152287054	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	125487947	152287054	96963567	2	8960										
ARHGEF11	9826	broad.mit.edu	37	chr1	157014118	157014118	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tactctggggtaaccttacaCtcatggtttctcggtgtctc	9	11	4	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:157014118C>G	ENST00000368194.3	-	1	1044	c.5G>C	c.(4-6)aGt>aCt	p.S2T	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.S2T	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	2					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TAACCTTACACTCATGGTTTC	0.433													60	49					0	0	1	0	0	G	157014118	C	G	157014118	3	3	49	1	0	0	0	0	1	0	0	0	893	565	20	5	4847	5	ARHGEF11	1	157014118	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	4727064	157014118	92236503	3	8961										
USF1	7391	broad.mit.edu	37	chr1	161010072	161010072	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	caagcggtggttactctgccGaagctcctggatataatcac	10	11	2	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:161010072G>A	ENST00000368021.3	-	10	967	c.763C>T	c.(763-765)Cgg>Tgg	p.R255W	USF1_ENST00000368019.1_Missense_Mutation_p.R227W|USF1_ENST00000368020.1_Missense_Mutation_p.R255W|USF1_ENST00000435396.1_Missense_Mutation_p.R196W	NM_007122.3	NP_009053.1	P22415	USF1_HUMAN	upstream transcription factor 1	255	Helix-loop-helix motif.				cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TTACTCTGCCGAAGCTCCTGG	0.478													4	152					0	0	1	0	0	A	161010072	G	A	161010072	3	1	49	1	0	0	0	0	1	0	0	0	17091	1057	37	1	177	1	USF1	1	161010072	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	3995954	161010072	88240549	4	8962										
DUSP27	92235	broad.mit.edu	37	chr1	167096275	167096275	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gctggagagaagccggcagaCgctggaggagagccagtcta	17	9	1	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:167096275C>T	ENST00000361200.2	+	6	2073	c.1907C>T	c.(1906-1908)aCg>aTg	p.T636M	DUSP27_ENST00000271385.5_Missense_Mutation_p.T636M|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.T636M			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	636					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGCCGGCAGACGCTGGAGGAG	0.632													27	28					0	0	1	0	0	T	167096275	C	T	167096275	3	4	49	1	0	0	0	0	1	0	0	0	4850	536	19	1	1925	1	DUSP27	1	167096275	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	6086203	167096275	82154346	5	8963										
HEATR1	55127	broad.mit.edu	37	chr1	236746150	236746150	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ctgctgtcttctttcagttgTtcaggattccaccatatatc	6	11	4	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:236746150T>C	ENST00000366582.3	-	19	2562	c.2448A>G	c.(2446-2448)gaA>gaG	p.E816E	HEATR1_ENST00000366581.2_Silent_p.E816E	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	816					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTTTCAGTTGTTCAGGATTCC	0.428													21	66					0	0	1	0	0	C	236746150	T	C	236746150	2	2	49	1	0	0	0	0	0	0	0	1	7067	1722	60	4		4	HEATR1	1	236746150	Silent	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	69649875	236746150	12504471	6	8964										
MEMO1	51072	broad.mit.edu	37	chr2	32108519	32108519	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	attcatcatagtaactgtaaCggaacctttgaccttgaaac	6	9	2	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr2:32108519C>G	ENST00000295065.4	-	7	902	c.593G>C	c.(592-594)cGt>cCt	p.R198P	MEMO1_ENST00000404530.1_Missense_Mutation_p.R198P|DPY30_ENST00000446765.1_5'UTR|MEMO1_ENST00000490459.1_Intron|MEMO1_ENST00000379383.3_Missense_Mutation_p.R201P|MEMO1_ENST00000426310.2_Missense_Mutation_p.R175P	NM_015955.2	NP_057039.1	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1	198					regulation of microtubule-based process	cytosol|nucleus				NS(1)|breast(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	17	Acute lymphoblastic leukemia(172;0.155)					GTAACTGTAACGGAACCTTTG	0.338													61	126					0	0	1	0	0	G	32108519	C	G	32108519	3	3	49	1	0	0	0	0	1	0	0	0	9520	536	19	5	312	5	MEMO1	2	32108519	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		32108519	211090854	7	8965										
PPIG	9360	broad.mit.edu	37	chr2	170494027	170494027	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ggaacagatgaagacaaaagCggatgagtgagttatataaa	12	3	0	5			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr2:170494027C>T	ENST00000260970.3	+	14	2479	c.2259C>T	c.(2257-2259)agC>agT	p.S753S	PPIG_ENST00000448752.2_Silent_p.S753S|PPIG_ENST00000409714.3_Silent_p.S738S	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	753					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AAGACAAAAGCGGATGAGTGA	0.313													14	11					0	0	1	0	0	T	170494027	C	T	170494027	2	4	49	1	0	0	0	0	0	0	0	1	12372	767	27	1		1	PPIG	2	170494027	Silent	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	138385508	170494027	72705346	8	8966										
FARSB	10056	broad.mit.edu	37	chr2	223499175	223499175	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atttagaggcttgaatttgaTatctgaaggacgctttgcag	11	5	1	4			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr2:223499175T>C	ENST00000281828.6	-	6	804	c.541A>G	c.(541-543)Atc>Gtc	p.I181V	FARSB_ENST00000536361.1_Missense_Mutation_p.I82V	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	181					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	TTGAATTTGATATCTGAAGGA	0.398													11	21					0	0	1	0	0	C	223499175	T	C	223499175	3	2	49	1	0	0	0	0	1	0	0	0	5712	1406	49	4	1276	4	FARSB	2	223499175	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	53005148	223499175	19700198	9	8967										
UBA7	7318	broad.mit.edu	37	chr3	49847420	49847420	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gtgcttcctacctgcagggtGtgctcggctgtgctagggaa	15	10	0	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:49847420G>A	ENST00000333486.3	-	14	1988	c.1830C>T	c.(1828-1830)caC>caT	p.H610H		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	610					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CCTGCAGGGTGTGCTCGGCTG	0.612													8	137					0	0	1	0	0	A	49847420	G	A	49847420	2	1	49	1	0	0	0	0	0	0	0	1	16893	1368	48	3		3	UBA7	3	49847420	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08		49847420	148175010	10	8968										
PTPRG	5793	broad.mit.edu	37	chr3	62188855	62188855	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gaccctttccagcccacagcGtctcctgcctcttcagccga	7	19	3	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:62188855G>A	ENST00000474889.1	+	12	1763	c.1386G>A	c.(1384-1386)gcG>gcA	p.A462A	PTPRG_ENST00000295874.10_Silent_p.A462A	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	462					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AGCCCACAGCGTCTCCTGCCT	0.547													33	62					0	0	1	0	0	A	62188855	G	A	62188855	2	1	49	1	0	0	0	0	0	0	0	1	12853	1132	40	1		1	PTPRG	3	62188855	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	12341435	62188855	135833575	11	8969										
NSUN3	63899	broad.mit.edu	37	chr3	93813928	93813928	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gaagctggttgttttcttctGactctcagaaggcatcctgt	10	9	3	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:93813928G>A	ENST00000314622.4	+	5	884	c.673G>A	c.(673-675)Gac>Aac	p.D225N		NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	225							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						GTTTTCTTCTGACTCTCAGAA	0.383													18	30					0	0	1	0	0	A	93813928	G	A	93813928	3	1	49	1	0	0	0	0	1	0	0	0	10726	1290	45	3	691	3	NSUN3	3	93813928	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	31625073	93813928	104208502	12	8970										
GOLGB1	2804	broad.mit.edu	37	chr3	121435639	121435639	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gcttgctcattcttatcttgGagaagctttgaattttgatc	8	7	3	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:121435639G>A	ENST00000393667.3	-	9	1343	c.1233C>T	c.(1231-1233)ctC>ctT	p.L411L	GOLGB1_ENST00000340645.5_Silent_p.L406L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	406					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TCTTATCTTGGAGAAGCTTTG	0.433													18	28					0	0	1	0	0	A	121435639	G	A	121435639	2	1	49	1	0	0	0	0	0	0	0	1	6603	1161	41	3		3	GOLGB1	3	121435639	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	27621711	121435639	76586791	13	8971										
TMEM108	66000	broad.mit.edu	37	chr3	133099186	133099186	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ccacacctctggggcagaagCggcccctggggaaaatcttt	12	13	2	1	rs145373217	byFrequency	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:133099186C>T	ENST00000515826.1	+	3	754	c.631C>T	c.(631-633)Cgg>Tgg	p.R211W	TMEM108_ENST00000321871.6_Missense_Mutation_p.R211W|TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000393130.3_Missense_Mutation_p.R211W			Q6UXF1	TM108_HUMAN	transmembrane protein 108	211						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GGGGCAGAAGCGGCCCCTGGG	0.592													36	32					0	0	1	0	0	T	133099186	C	T	133099186	3	4	49	1	0	0	0	0	1	0	0	0	16083	759	27	1	637	1	TMEM108	3	133099186	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	11663547	133099186	64923244	14	8972										
COPB2	9276	broad.mit.edu	37	chr3	139078198	139078198	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	attaagagctctaggcaggcAtcaaccctaaacattaaaaa	6	9	2	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:139078198A>G	ENST00000333188.5	-	18	2398	c.2217T>C	c.(2215-2217)gaT>gaC	p.D739D	COPB2_ENST00000507777.1_Silent_p.D710D	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	739					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						CTAGGCAGGCATCAACCCTAA	0.393													29	37					0	0	1	0	0	G	139078198	A	G	139078198	2	3	49	1	0	0	0	0	0	0	0	1	3752	214	8	4		4	COPB2	3	139078198	Silent	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08	5979012	139078198	58944232	15	8973										
LRRIQ4	344657	broad.mit.edu	37	chr3	169540472	169540472	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ccatcccgaagagcttcgccGagctcaggaagatgacggaa	12	12	1	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:169540472G>A	ENST00000340806.6	+	1	763	c.763G>A	c.(763-765)Gag>Aag	p.E255K		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	255										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						GAGCTTCGCCGAGCTCAGGAA	0.607													95	21					0	0	1	0	0	A	169540472	G	A	169540472	3	1	49	1	0	0	0	0	1	0	0	0	9075	1059	37	1	765	1	LRRIQ4	3	169540472	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	30462274	169540472	28481958	16	8974										
PIK3CA	5290	broad.mit.edu	37	chr3	178952007	178952007	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atcttttgatgacattgcatAcattcgaaagaccctagcct	6	10	1	3	rs121913288		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:178952007A>G	ENST00000263967.3	+	21	3219	c.3062A>G	c.(3061-3063)tAc>tGc	p.Y1021C		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1021	PI3K/PI4K.		Y -> C (in cancer).|Y -> H (in cancer).|Y -> N (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Y1021C(23)|p.Y1021F(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GACATTGCATACATTCGAAAG	0.388		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			126	25					0	0	1	0	0	G	178952007	A	G	178952007	3	3	49	1	0	0	0	0	1	0	0	0	11960	391	14	4	3140	4	PIK3CA	3	178952007	Missense_Mutation	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08	9411535	178952007	19070423	17	8975										
LIPH	200879	broad.mit.edu	37	chr3	185252705	185252705	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	caaaccctttactaagtcatCcatccaaacaggaggggagc	8	12	1	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:185252705C>T	ENST00000296252.4	-	2	406	c.265G>A	c.(265-267)Gat>Aat	p.D89N	LIPH_ENST00000424591.2_Missense_Mutation_p.D89N	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	89					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			ACTAAGTCATCCATCCAAACA	0.438													153	45					0	0	1	0	0	T	185252705	C	T	185252705	3	4	49	1	0	0	0	0	1	0	0	0	8864	855	30	3	1126	3	LIPH	3	185252705	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	6300698	185252705	12769725	18	8976										
TLR1	7096	broad.mit.edu	37	chr4	38800071	38800071	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ctctttgcatataggcagggCatcaaatgcattaaatgaca	8	8	2	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:38800071C>A	ENST00000308979.2	-	4	655	c.382G>T	c.(382-384)Gcc>Tcc	p.A128S	TLR1_ENST00000502213.2_Missense_Mutation_p.A128S	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	128					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						ATAGGCAGGGCATCAAATGCA	0.418													46	62					5.48756e-27	6.10351e-27	1	1	0	A	38800071	C	A	38800071	3	1	49	1	0	0	0	0	1	0	0	0	16008	710	25	5	1982	5	TLR1	4	38800071	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		38800071	152354205	19	8977										
WDR19	57728	broad.mit.edu	37	chr4	39229838	39229838	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tttattttgtaggtcaatgaCgctacctatgagattccaga	8	7	1	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:39229838C>T	ENST00000399820.3	+	16	1792	c.1638C>T	c.(1636-1638)gaC>gaT	p.D546D	WDR19_ENST00000288634.7_Silent_p.D386D	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	546					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AGGTCAATGACGCTACCTATG	0.383													5	11					0	0	1	0	0	T	39229838	C	T	39229838	2	4	49	1	0	0	0	0	0	0	0	1	17338	535	19	1		1	WDR19	4	39229838	Silent	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	429767	39229838	151924438	20	8978										
GSTCD	79807	broad.mit.edu	37	chr4	106638979	106638979	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aagagatgacctgatccaggAtgttgaaatacagattattt	9	5	0	5			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:106638979A>G	ENST00000515279.1	+	2	429	c.209A>G	c.(208-210)gAt>gGt	p.D70G	GSTCD_ENST00000394728.3_Missense_Mutation_p.D70G|GSTCD_ENST00000394730.3_Intron|GSTCD_ENST00000360505.5_Missense_Mutation_p.D70G|GSTCD_ENST00000507281.1_Intron|GSTCD_ENST00000515255.1_Intron			Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain containing	70						cytoplasm	rRNA methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	14		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		CTGATCCAGGATGTTGAAATA	0.383													27	40					0	0	1	0	0	G	106638979	A	G	106638979	3	3	49	1	0	0	0	0	1	0	0	0	6875	333	12	4	211	4	GSTCD	4	106638979	Missense_Mutation	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08	67409141	106638979	84515297	21	8979										
FBXW7	0	broad.mit.edu	37	chr4	153249384	153249384	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tttcatgaagatgcatacaaCgcacagtggaagtatgccca	9	9	1	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:153249384C>G	ENST00000281708.4	-	9	2623	c.1394G>C	c.(1393-1395)cGt>cCt	p.R465P	FBXW7_ENST00000296555.5_Missense_Mutation_p.R347P|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465P|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385P|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465P|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289P	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465H(69)|p.R385H(16)|p.R226H(16)|p.R465L(4)|p.R347H(4)|p.R465Y(2)|p.?(1)|p.R385L(1)|p.R226L(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATGCATACAACGCACAGTGGA	0.408			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								42	57					0	0	1	0	0	G	153249384	C	G	153249384	3	3	49	1	0	0	0	0	1	0	0	0	5801	536	19	5	745	5	FBXW7	4	153249384	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	46610405	153249384	37904892	22	8980										
FER	2241	broad.mit.edu	37	chr5	108203563	108203563	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tattggcgttgaaaggggcaCagctccatcagaatcagtat	11	8	2	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr5:108203563C>T	ENST00000281092.4	+	6	961	c.577C>T	c.(577-579)Cag>Tag	p.Q193*	FER_ENST00000438717.2_Nonsense_Mutation_p.Q18*|FER_ENST00000536402.1_Nonsense_Mutation_p.Q193*	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	193	Important for interaction with membranes containing phosphoinositides.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GAAAGGGGCACAGCTCCATCA	0.403													7	32					0	0	1	0	0	T	108203563	C	T	108203563	4	4	49	1	0	0	0	0	0	1	0	0	5845	479	17	3	591	3	FER	5	108203563	Nonsense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		108203563	72711697	23	8981										
WDR36	134430	broad.mit.edu	37	chr5	110438053	110438053	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tcttcttgtagtaaacttctAtatacatttccaggatggaa	6	7	3	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr5:110438053A>G	ENST00000506538.2	+	6	1293	c.720A>G	c.(718-720)ctA>ctG	p.L240L	WDR36_ENST00000513710.2_Silent_p.L240L|WDR36_ENST00000505303.1_Silent_p.L184L	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	240					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GTAAACTTCTATATACATTTC	0.303													19	9					0	0	1	0	0	G	110438053	A	G	110438053	2	3	49	1	0	0	0	0	0	0	0	1	17349	436	16	4		4	WDR36	5	110438053	Silent	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08	2234490	110438053	70477207	24	8982										
B4GALT7	11285	broad.mit.edu	37	chr5	177031297	177031297	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	cagctcagctgctctggggaCgtggcccgggcagtcagggg	18	12	3	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr5:177031297C>T	ENST00000029410.5	+	2	279	c.168C>T	c.(166-168)gaC>gaT	p.D56D		NM_007255.2	NP_009186.1	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7	56					fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)|urinary_tract(1)	7	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTCTGGGGACGTGGCCCGGG	0.682													4	26					0	0	1	0	0	T	177031297	C	T	177031297	2	4	49	1	0	0	0	0	0	0	0	1	1274	535	19	1		1	B4GALT7	5	177031297	Silent	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	66593244	177031297	3883963	25	8983										
JARID2	3720	broad.mit.edu	37	chr6	15497073	15497073	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gtgcacaagccgcaggactcGggcaaggccgagaagggcgg	18	11	0	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:15497073G>T	ENST00000341776.2	+	7	1861	c.1617G>T	c.(1615-1617)tcG>tcT	p.S539S	JARID2_ENST00000397311.3_Silent_p.S367S|JARID2_ENST00000541660.1_Silent_p.S501S	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	539					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding	p.S539S(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CGCAGGACTCGGGCAAGGCCG	0.657													21	33					4.96729e-08	5.36074e-08	1	1	0	T	15497073	G	T	15497073	2	4	49	1	0	0	0	0	0	0	0	1	7988	1103	39	5		5	JARID2	6	15497073	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08		15497073	155617994	26	8984										
ABCC10	89845	broad.mit.edu	37	chr6	43401078	43401078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gcaaccaggaaatgctacagCacaaggatgcgcgggttaag	13	9	0	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:43401078C>T	ENST00000244533.3	+	1	1590	c.1231C>T	c.(1231-1233)Cac>Tac	p.H411Y	ABCC10_ENST00000372530.4_Missense_Mutation_p.H454Y|ABCC10_ENST00000443426.2_3'UTR	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	454	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AATGCTACAGCACAAGGATGC	0.597													32	23					0	0	1	0	0	T	43401078	C	T	43401078	3	4	49	1	0	0	0	0	1	0	0	0	50	710	25	3	1233	3	ABCC10	6	43401078	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	27904005	43401078	127713989	27	8985										
UTRN	7402	broad.mit.edu	37	chr6	144780347	144780347	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tcttggccttcaccccaaaaTtgaaatggctcgtgcaagct	8	12	2	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:144780347T>C	ENST00000367545.3	+	20	2564	c.2564T>C	c.(2563-2565)aTt>aCt	p.I855T		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	855	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CACCCCAAAATTGAAATGGCT	0.498													11	56					0	0	1	0	0	C	144780347	T	C	144780347	3	2	49	1	0	0	0	0	1	0	0	0	17162	1493	52	4	2642	4	UTRN	6	144780347	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	101379269	144780347	26334720	28	8986										
GLI3	2737	broad.mit.edu	37	chr7	42004014	42004014	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gatagccatgttggtggtgcTcatggacagcgctgggaatg	16	7	1	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr7:42004014T>C	ENST00000395925.3	-	15	4741	c.4657A>G	c.(4657-4659)Agc>Ggc	p.S1553G	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1553					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TTGGTGGTGCTCATGGACAGC	0.547									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				29	33					0	0	1	0	0	C	42004014	T	C	42004014	3	2	49	1	0	0	0	0	1	0	0	0	6480	1551	54	4	89	4	GLI3	7	42004014	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08		42004014	117134649	29	8987										
MCM7	4176	broad.mit.edu	37	chr7	99696771	99696771	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	cttccccacagagtcagcccGcacttcccggatcacacgag	8	18	2	1	rs150260409		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr7:99696771G>A	ENST00000303887.5	-	5	1102	c.457C>T	c.(457-459)Cgg>Tgg	p.R153W	MCM7_ENST00000354230.3_5'UTR|MCM7_ENST00000343023.6_Missense_Mutation_p.R153W	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	153					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GAGTCAGCCCGCACTTCCCGG	0.512													8	158					0	0	1	0	0	A	99696771	G	A	99696771	3	1	49	1	0	0	0	0	1	0	0	0	9441	1086	38	1	1746	1	MCM7	7	99696771	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	57692757	99696771	59441892	30	8988										
ZFPM2	23414	broad.mit.edu	37	chr8	106814196	106814196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aacatcttgcatcaattcttCcactgtcttagatttaattg	4	9	4	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr8:106814196C>T	ENST00000407775.2	+	8	2136	c.1886C>T	c.(1885-1887)tCc>tTc	p.S629F	RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S497F|ZFPM2_ENST00000520492.1_Missense_Mutation_p.S497F|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S360F|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	629					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ATCAATTCTTCCACTGTCTTA	0.443													24	72					0	0	1	0	0	T	106814196	C	T	106814196	3	4	49	1	0	0	0	0	1	0	0	0	17715	855	30	3	1916	3	ZFPM2	8	106814196	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		106814196	39549826	31	8989										
KCNQ3	3786	broad.mit.edu	37	chr8	133141882	133141882	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	agtcgagaagagtcaagataGgcaggaccgtgggcctctcc	14	10	2	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr8:133141882G>A	ENST00000388996.4	-	15	2666	c.2246C>T	c.(2245-2247)cCt>cTt	p.P749L	KCNQ3_ENST00000521134.1_Missense_Mutation_p.P629L|KCNQ3_ENST00000519445.1_Missense_Mutation_p.P737L	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	749					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AGTCAAGATAGGCAGGACCGT	0.617													34	44					0	0	1	0	0	A	133141882	G	A	133141882	3	1	49	1	0	0	0	0	1	0	0	0	8127	1000	35	3	376	3	KCNQ3	8	133141882	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	26327686	133141882	13222140	32	8990										
ZFAT	57623	broad.mit.edu	37	chr8	135545196	135545196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atatgttgcaggagtaatggCaatgggcacagcggaaaggc	15	6	0	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr8:135545196C>T	ENST00000520727.1	-	13	3259	c.2960G>A	c.(2959-2961)tGc>tAc	p.C987Y	ZFAT_ENST00000517307.1_5'UTR|ZFAT_ENST00000429442.2_Missense_Mutation_p.C987Y|ZFAT_ENST00000520214.1_Missense_Mutation_p.C987Y|ZFAT_ENST00000523399.1_Missense_Mutation_p.C937Y|ZFAT_ENST00000520356.1_Missense_Mutation_p.C987Y|ZFAT_ENST00000377838.3_Missense_Mutation_p.C999Y	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	999					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGAGTAATGGCAATGGGCACA	0.587													16	14					0	0	1	0	0	T	135545196	C	T	135545196	3	4	49	1	0	0	0	0	1	0	0	0	17689	710	25	3	755	3	ZFAT	8	135545196	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	2403314	135545196	10818826	33	8991										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18622331	18622331	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ggtccacctgccggctggtcCgagggcagtataaatcccag	13	13	0	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr9:18622331C>T	ENST00000380548.4	+	5	904	c.565C>T	c.(565-567)Cga>Tga	p.R189*	ADAMTSL1_ENST00000276935.6_Nonsense_Mutation_p.R189*|ADAMTSL1_ENST00000380570.4_Nonsense_Mutation_p.R189*|ADAMTSL1_ENST00000327883.7_Nonsense_Mutation_p.R189*|ADAMTSL1_ENST00000380566.4_Nonsense_Mutation_p.R189*	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	189						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCGGCTGGTCCGAGGGCAGTA	0.532													29	61					0	0	1	0	0	T	18622331	C	T	18622331	4	4	49	1	0	0	0	0	0	1	0	0	273	644	23	1	583	1	ADAMTSL1	9	18622331	Nonsense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		18622331	122591100	34	8992										
IFT74	80173	broad.mit.edu	37	chr9	26961996	26961996	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atcacaaatcttcagcagctCgccctgtttcaagaggtgga	9	11	4	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr9:26961996C>T	ENST00000443698.1	+	2	202	c.31C>T	c.(31-33)Cgc>Tgc	p.R11C	IFT74_ENST00000429045.2_Missense_Mutation_p.R11C|IFT74_ENST00000433700.1_Missense_Mutation_p.R11C|IFT74_ENST00000380062.5_Missense_Mutation_p.R11C	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	11						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TTCAGCAGCTCGCCCTGTTTC	0.433													45	42					0	0	1	0	0	T	26961996	C	T	26961996	3	4	49	1	0	0	0	0	1	0	0	0	7606	884	31	1	33	1	IFT74	9	26961996	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	8339665	26961996	114251435	35	8993										
GARNL3	84253	broad.mit.edu	37	chr9	130095380	130095380	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aaagggctggacgggctaccGtggcggtctggataccaaaa	15	9	1	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr9:130095380G>A	ENST00000373387.4	+	9	1101	c.749G>A	c.(748-750)cGt>cAt	p.R250H	GARNL3_ENST00000314904.5_Missense_Mutation_p.R250H|GARNL3_ENST00000435213.2_Missense_Mutation_p.R228H	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	250	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						ACGGGCTACCGTGGCGGTCTG	0.428													49	5					0	0	1	0	0	A	130095380	G	A	130095380	3	1	49	1	0	0	0	0	1	0	0	0	6280	1145	40	1	783	1	GARNL3	9	130095380	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	103133384	130095380	11118051	36	8994										
MKX	283078	broad.mit.edu	37	chr10	28023623	28023623	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	cgtgactctggcctcactccCgctttgatgaccgaattctc	8	15	3	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr10:28023623C>T	ENST00000375790.5	-	5	1032	c.600G>A	c.(598-600)gcG>gcA	p.A200A	MKX_ENST00000419761.1_Silent_p.A200A			Q8IYA7	MKX_HUMAN	mohawk homeobox	200					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						GCCTCACTCCCGCTTTGATGA	0.488													22	83					0	0	1	0	0	T	28023623	C	T	28023623	2	4	49	1	0	0	0	0	0	0	0	1	9657	639	23	1		1	MKX	10	28023623	Silent	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		28023623	107511124	37	8995										
SLC25A28	81894	broad.mit.edu	37	chr10	101379857	101379857	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ccaggatccctgccacggcgCctgccaccatgtgcgtggtg	13	16	0	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr10:101379857C>G	ENST00000370495.4	-	1	264	c.236G>C	c.(235-237)gGc>gCc	p.G79A	SLC25A28_ENST00000496035.1_Intron	NM_031212.3	NP_112489.3	Q96A46	MFRN2_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 28	79					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|stomach(1)	11		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)		TGCCACGGCGCCTGCCACCAT	0.692													8	17					0	0	1	0	0	G	101379857	C	G	101379857	3	3	49	1	0	0	0	0	1	0	0	0	14545	739	26	5	874	5	SLC25A28	10	101379857	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	73356234	101379857	34154890	38	8996										
PNLIPRP2	5408	broad.mit.edu	37	chr10	118383815	118383816	+	RNA	INS	-	-	CA													0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aacccagaaacttacacattINScacacacactggtgcagaga					rs144051797	by1000genomes	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr10:118383815_118383816insCA	ENST00000537242.1	+	0	230				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		acttacacattcacacacactg	0.485													3	4	---	---	---	---						CA	118383816	-	CA	118383815	6	5	49	0	1	1	1	0	0	0	0	0	12198	1798	62	0		0	PNLIPRP2	10	118383815	RNA	INS	-	TCGA-ND-A4WF-01A-11D-A28R-08	17003958	118383815	17150932	39	8997										
TRIM5	85363	broad.mit.edu	37	chr11	5701143	5701143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	acaatgatcaactttctgccCctctgggctcaacttgacct	6	14	4	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr11:5701143C>T	ENST00000305836.5	-	2	567	c.265G>A	c.(265-267)Ggg>Agg	p.G89R	TRIM5_ENST00000380034.3_Missense_Mutation_p.G89R|TRIM5_ENST00000380027.1_Missense_Mutation_p.G89R|TRIM5_ENST00000396847.3_Missense_Mutation_p.G89R|TRIM5_ENST00000396853.4_Missense_Mutation_p.G89R|TRIM5_ENST00000396855.3_Missense_Mutation_p.G89R			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	89					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		ACTTTCTGCCCCTCTGGGCTC	0.532													5	71					0	0	1	0	0	T	5701143	C	T	5701143	3	4	49	1	0	0	0	0	1	0	0	0	16585	623	22	3	1483	3	TRIM5	11	5701143	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		5701143	129305373	40	8998										
OR4X1	390113	broad.mit.edu	37	chr11	48285756	48285756	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tgaggcctttctcctgatggTgatggcctatgaccgctatg	12	10	1	4			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr11:48285756T>C	ENST00000320048.1	+	1	344	c.344T>C	c.(343-345)gTg>gCg	p.V115A		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						CTCCTGATGGTGATGGCCTAT	0.517													23	30					0	0	1	0	0	C	48285756	T	C	48285756	3	2	49	1	0	0	0	0	1	0	0	0	11131	1696	59	4	346	4	OR4X1	11	48285756	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	42584613	48285756	86720760	41	8999										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57076216	57076216	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	cctccagagtctgggtcacaGgtcacctccaaatccctcag	8	16	4	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr11:57076216G>C	ENST00000532437.1	-	5	4280	c.3969C>G	c.(3967-3969)acC>acG	p.T1323T	TNKS1BP1_ENST00000358252.3_Silent_p.T1323T			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1323	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGGGTCACAGGTCACCTCCA	0.612													206	252					0	0	1	0	0	C	57076216	G	C	57076216	2	2	49	1	0	0	0	0	0	0	0	1	16379	987	35	5		5	TNKS1BP1	11	57076216	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	8790460	57076216	77930300	42	9000										
CHD4	1108	broad.mit.edu	37	chr12	6686974	6686974	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aaaccttcgagctagaaattTattcttgatctctaagaaat	5	7	2	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:6686974T>C	ENST00000309577.6	-	36	5585	c.5422A>G	c.(5422-5424)Aaa>Gaa	p.K1808E	CHD4_ENST00000544484.1_Missense_Mutation_p.K1805E|CHD4_ENST00000544040.1_Missense_Mutation_p.K1773E|CHD4_ENST00000357008.2_Missense_Mutation_p.K1780E			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1780	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCTAGAAATTTATTCTTGATC	0.468													100	2					0	0	1	0	0	C	6686974	T	C	6686974	3	2	49	1	0	0	0	0	1	0	0	0	3349	1763	61	4	416	4	CHD4	12	6686974	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08		6686974	127164921	43	9001										
APOBEC1	339	broad.mit.edu	37	chr12	7803729	7803729	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gacaaaattcctccagcagtGataatactctaaggaaacac	6	10	1	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:7803729G>T	ENST00000229304.4	-	4	471	c.451C>A	c.(451-453)Cac>Aac	p.H151N		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	151					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CTCCAGCAGTGATAATACTCT	0.458													48	25					1.23103e-26	1.35537e-26	1	1	0	T	7803729	G	T	7803729	3	4	49	1	0	0	0	0	1	0	0	0	784	1290	45	2	267	2	APOBEC1	12	7803729	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	1116755	7803729	126048166	44	9002										
PTPRO	5800	broad.mit.edu	37	chr12	15704527	15704527	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ggtagtgatctccgtgctggCcatccttagcacacttttaa	9	11	1	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:15704527C>T	ENST00000281171.4	+	15	2810	c.2480C>T	c.(2479-2481)gCc>gTc	p.A827V	PTPRO_ENST00000544244.1_Missense_Mutation_p.A16V|PTPRO_ENST00000445537.2_Missense_Mutation_p.A16V|PTPRO_ENST00000442921.2_Missense_Mutation_p.A16V|PTPRO_ENST00000542557.1_Missense_Mutation_p.A16V|PTPRO_ENST00000348962.2_Missense_Mutation_p.A827V	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	827						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TCCGTGCTGGCCATCCTTAGC	0.383													4	116					0	0	1	0	0	T	15704527	C	T	15704527	3	4	49	1	0	0	0	0	1	0	0	0	12860	739	26	3	2538	3	PTPRO	12	15704527	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	7900798	15704527	118147368	45	9003										
ABCC9	10060	broad.mit.edu	37	chr12	22040812	22040812	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gaagcgaactttcaccagttCgccaactgtcgtcaccaatc	7	14	2	0	rs139539832		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:22040812C>A	ENST00000261200.4	-	13	1858	c.1859G>T	c.(1858-1860)cGa>cTa	p.R620L	ABCC9_ENST00000345162.2_Missense_Mutation_p.R620L|RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000261201.4_Missense_Mutation_p.R620L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	620					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTCACCAGTTCGCCAACTGTC	0.383													7	347					0.00307968	0.00316684	1	1	0	A	22040812	C	A	22040812	3	1	49	1	0	0	0	0	1	0	0	0	59	884	31	2	3036	2	ABCC9	12	22040812	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	6336285	22040812	111811083	46	9004										
LUM	4060	broad.mit.edu	37	chr12	91502614	91502614	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	catcacagtacatggcacttGggtagctttcagggcagtta	11	9	2	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:91502614G>A	ENST00000266718.4	-	2	597	c.143C>T	c.(142-144)cCa>cTa	p.P48L	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	48	Cys-rich.|LRRNT.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CATGGCACTTGGGTAGCTTTC	0.418													18	23					0	0	1	0	0	A	91502614	G	A	91502614	3	1	49	1	0	0	0	0	1	0	0	0	9129	1348	47	3	881	3	LUM	12	91502614	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	69461802	91502614	42349281	47	9005										
SLC5A8	160728	broad.mit.edu	37	chr12	101551128	101551128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gtggttgaaagcaggattatCagttccaccatcttccactg	9	10	2	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:101551128C>G	ENST00000536262.2	-	15	2320	c.1762G>C	c.(1762-1764)Gat>Cat	p.D588H		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	588					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCAGGATTATCAGTTCCACCA	0.388													11	15					0	0	1	0	0	G	101551128	C	G	101551128	3	3	49	1	0	0	0	0	1	0	0	0	14725	826	29	2	74	2	SLC5A8	12	101551128	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	10048514	101551128	32300767	48	9006										
C12orf42	374470	broad.mit.edu	37	chr12	103696308	103696308	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ctggctcctcctgcagaggcCgatggcagtggaaggtctgg	16	11	1	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:103696308C>T	ENST00000548048.1	-	9	956	c.460G>A	c.(460-462)Ggc>Agc	p.G154S	C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000548883.1_Missense_Mutation_p.G221S|C12orf42_ENST00000378113.2_Missense_Mutation_p.G221S			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	221										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						CTGCAGAGGCCGATGGCAGTG	0.667													34	57					0	0	1	0	0	T	103696308	C	T	103696308	3	4	49	1	0	0	0	0	1	0	0	0	1694	652	23	1	425	1	C12orf42	12	103696308	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	2145180	103696308	30155587	49	9007										
SEC23A	10484	broad.mit.edu	37	chr14	39556161	39556161	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aggaggtggctgctgtacctGaggaccacgtgttgcttgag	16	8	0	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr14:39556161G>A	ENST00000537403.1	-	2	1251	c.49C>T	c.(49-51)Cag>Tag	p.Q17*	SEC23A_ENST00000307712.6_Nonsense_Mutation_p.Q219*|SEC23A_ENST00000545328.2_Nonsense_Mutation_p.Q190*|SEC23A_ENST00000536508.1_Nonsense_Mutation_p.Q93*			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	219					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TGCTGTACCTGAGGACCACGT	0.383													24	9					0	0	1	0	0	A	39556161	G	A	39556161	4	1	49	1	0	0	0	0	0	1	0	0	14044	1299	45	3	1702	3	SEC23A	14	39556161	Nonsense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08		39556161	67793379	50	9008										
NUDT14	256281	broad.mit.edu	37	chr14	105639417	105639417	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ccatgagacaccaaagatgaCgccgagggtcttggggatgt	14	9	1	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr14:105639417C>T	ENST00000392568.2	-	5	703	c.610G>A	c.(610-612)Gtc>Atc	p.V204I	RP11-44N21.4_ENST00000548203.1_RNA|NUDT14_ENST00000550912.1_5'UTR	NM_177533.4	NP_803877.2	O95848	NUD14_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 14	204	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity	p.V204I(1)		cervix(2)|endometrium(1)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	14		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCAAAGATGACGCCGAGGGTC	0.627										HNSCC(42;0.11)			57	22					0	0	1	0	0	T	105639417	C	T	105639417	3	4	49	1	0	0	0	0	1	0	0	0	10777	536	19	1	62	1	NUDT14	14	105639417	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	66083256	105639417	1710123	51	9009										
NFAT5	10725	broad.mit.edu	37	chr16	69724960	69724960	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tgttactccaatggaagtaaCagcagaaaaaagatcttcca	7	8	1	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr16:69724960C>A	ENST00000349945.1	+	13	3162	c.1610C>A	c.(1609-1611)aCa>aAa	p.T537K	NFAT5_ENST00000566899.1_Missense_Mutation_p.T537K|NFAT5_ENST00000393742.2_Missense_Mutation_p.T537K|NFAT5_ENST00000567239.1_Missense_Mutation_p.T630K|NFAT5_ENST00000354436.2_Missense_Mutation_p.T613K|NFAT5_ENST00000432919.1_Missense_Mutation_p.T631K	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	613					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ATGGAAGTAACAGCAGAAAAA	0.328													13	31					7.03913e-09	7.67265e-09	1	1	0	A	69724960	C	A	69724960	3	1	49	1	0	0	0	0	1	0	0	0	10406	478	17	5	1938	5	NFAT5	16	69724960	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		69724960	20629793	52	9010										
DNAH2	146754	broad.mit.edu	37	chr17	7683556	7683556	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ggtggtgcctgactccacccTcattgcagaaatcattctct	8	13	3	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:7683556T>A	ENST00000572933.1	+	37	7264	c.5804T>A	c.(5803-5805)cTc>cAc	p.L1935H	DNAH2_ENST00000389173.2_Missense_Mutation_p.L1935H			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1935	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GACTCCACCCTCATTGCAGAA	0.453													10	149					0	0	1	0	0	A	7683556	T	A	7683556	3	1	49	1	0	0	0	0	1	0	0	0	4630	1551	54	4	5946	4	DNAH2	17	7683556	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08		7683556	73511654	53	9011										
NOS2	4843	broad.mit.edu	37	chr17	26116637	26116637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gtgactcactgacctttcccGtctccacgaggggctgcggg	13	14	2	2	rs141421929	byFrequency	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:26116637G>A	ENST00000313735.6	-	3	421	c.188C>T	c.(187-189)aCg>aTg	p.T63M		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	63					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GACCTTTCCCGTCTCCACGAG	0.567													78	3					0	0	1	0	0	A	26116637	G	A	26116637	3	1	49	1	0	0	0	0	1	0	0	0	10589	1145	40	1	3373	1	NOS2	17	26116637	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	18433081	26116637	55078573	54	9012										
UNC119	9094	broad.mit.edu	37	chr17	26875096	26875096	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	cccagcattggggtccaggtCccgccggttgatgggcaacc	14	14	0	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:26875096C>T	ENST00000484980.1	-	2	3234	c.73G>A	c.(73-75)Gac>Aac	p.D25N	UNC119_ENST00000470125.1_Missense_Mutation_p.D25N|UNC119_ENST00000301032.4_Missense_Mutation_p.D120N|UNC119_ENST00000335765.4_Missense_Mutation_p.D120N			Q13432	U119A_HUMAN	unc-119 homolog (C. elegans)	120					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction				breast(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	7	Lung NSC(42;0.00431)					GGGTCCAGGTCCCGCCGGTTG	0.652											OREG0024277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	2					0	0	1	0	0	T	26875096	C	T	26875096	3	4	49	1	0	0	0	0	1	0	0	0	17041	855	30	3	429	3	UNC119	17	26875096	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	758459	26875096	54320114	55	9013										
CCL14	6358	broad.mit.edu	37	chr17	34310906	34310906	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gggttggtacagacggaatgGccccttttggtgatgaagct	15	7	0	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:34310906G>A	ENST00000480944.2	-	2	2685	c.279C>T	c.(277-279)ggC>ggT	p.G93G	CCL15-CCL14_ENST00000481427.2_3'UTR|CTB-186H2.3_ENST00000593057.1_Intron|CCL14_ENST00000536149.1_Silent_p.G87G|CCL14_ENST00000394509.4_Silent_p.G71G|CCL14_ENST00000586216.1_3'UTR|CCL14_ENST00000435911.2_Silent_p.G87G			Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14	71					cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|lung(6)	7		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGACGGAATGGCCCCTTTTGG	0.557													5	52					0	0	1	0	0	A	34310906	G	A	34310906	2	1	49	1	0	0	0	0	0	0	0	1	2905	1190	42	3		3	CCL14	17	34310906	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	7435810	34310906	46884304	56	9014										
LRRC37A3	374819	broad.mit.edu	37	chr17	62892272	62892272	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gattcgacctccctagaagaCtcagaaggctgaactggctg	11	11	1	4			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:62892272C>G	ENST00000584306.1	-	3	1634	c.1104G>C	c.(1102-1104)gaG>gaC	p.E368D	RP11-927P21.1_ENST00000584959.1_RNA|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.E368D|RP11-927P21.1_ENST00000584131.1_RNA|RP11-927P21.1_ENST00000577938.1_RNA|LRRC37A3_ENST00000339474.5_Intron|LRRC37A3_ENST00000400877.3_Intron	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	368						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						CCCTAGAAGACTCAGAAGGCT	0.537													90	399					0	0	1	0	0	G	62892272	C	G	62892272	3	3	49	1	0	0	0	0	1	0	0	0	9037	564	20	5	3848	5	LRRC37A3	17	62892272	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	28581366	62892272	18302938	57	9015										
GAA	2548	broad.mit.edu	37	chr17	78081505	78081505	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	caggatcaccctgtggaaccGggaccttgcgcccacggtac	12	15	1	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:78081505G>A	ENST00000302262.3	+	4	1061	c.842G>A	c.(841-843)cGg>cAg	p.R281Q	GAA_ENST00000390015.3_Missense_Mutation_p.R281Q	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	281					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	CTGTGGAACCGGGACCTTGCG	0.692													68	41					0	0	1	0	0	A	78081505	G	A	78081505	3	1	49	1	0	0	0	0	1	0	0	0	6181	1116	39	1	852	1	GAA	17	78081505	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	15189233	78081505	3113705	58	9016										
ONECUT2	9480	broad.mit.edu	37	chr18	55102969	55102969	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atgaaggctgcctacaccgcCtatcgatgcctcaccaaaga	8	14	1	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr18:55102969C>G	ENST00000491143.2	+	1	53	c.21C>G	c.(19-21)gcC>gcG	p.A7A		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	7					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		CCTACACCGCCTATCGATGCC	0.721													8	20					0	0	1	0	0	G	55102969	C	G	55102969	2	3	49	1	0	0	0	0	0	0	0	1	10916	668	24	5		5	ONECUT2	18	55102969	Silent	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		55102969	22974279	59	9017										
FBN3	84467	broad.mit.edu	37	chr19	8206865	8206865	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tattggggatgaagccgcggCggcaggggtgtggctgtgca	20	7	0	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:8206865C>T	ENST00000600128.1	-	7	1112	c.698G>A	c.(697-699)cGc>cAc	p.R233H	FBN3_ENST00000270509.2_Missense_Mutation_p.R233H|FBN3_ENST00000601739.1_Missense_Mutation_p.R233H			Q75N90	FBN3_HUMAN	fibrillin 3	233	TB 1.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GAAGCCGCGGCGGCAGGGGTG	0.637													20	51					0	0	1	0	0	T	8206865	C	T	8206865	3	4	49	1	0	0	0	0	1	0	0	0	5736	768	27	1	7963	1	FBN3	19	8206865	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08		8206865	50922118	60	9018										
ZNF560	147741	broad.mit.edu	37	chr19	9578448	9578448	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tgtgagttcgtacatgttcaAgaaagcctgacggcacagtg	12	8	1	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:9578448A>G	ENST00000301480.4	-	10	1388	c.1175T>C	c.(1174-1176)cTt>cCt	p.L392P		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TACATGTTCAAGAAAGCCTGA	0.428													35	56					0	0	1	0	0	G	9578448	A	G	9578448	3	3	49	1	0	0	0	0	1	0	0	0	18047	72	3	4	1201	4	ZNF560	19	9578448	Missense_Mutation	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08	1371583	9578448	49550535	61	9019										
CACNA1A	773	broad.mit.edu	37	chr19	13470526	13470526	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tcccgttgttgggcccttccCagtagggctgacatttggtc	12	12	0	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:13470526C>A	ENST00000360228.5	-	6	871	c.872G>T	c.(871-873)tGg>tTg	p.W291L	CACNA1A_ENST00000573710.2_Missense_Mutation_p.W291L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	291					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGGCCCTTCCCAGTAGGGCTG	0.547													5	4					0.00116845	0.00121296	1	1	0	A	13470526	C	A	13470526	3	1	49	1	0	0	0	0	1	0	0	0	2556	595	21	5	6930	5	CACNA1A	19	13470526	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	3892078	13470526	45658457	62	9020										
SIGLEC10	89790	broad.mit.edu	37	chr19	51920476	51920476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	agttccccttggcgggatccCcagtgagctggaatcggccc	13	14	0	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:51920476C>T	ENST00000353836.5	-	2	502	c.281G>A	c.(280-282)gGg>gAg	p.G94E	CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.G94E|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.G94E|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.G94E|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.G94E|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.G94E|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.G94E|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.G94E|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.G94E	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	94	Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GGCGGGATCCCCAGTGAGCTG	0.562													51	37					0	0	1	0	0	T	51920476	C	T	51920476	3	4	49	1	0	0	0	0	1	0	0	0	14360	623	22	3	1852	3	SIGLEC10	19	51920476	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	38449950	51920476	7208507	63	9021										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715971	52715971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	cctgtgctcagatgacacccCcatggtgcggcgggccgcag	14	15	1	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:52715971C>G	ENST00000322088.6	+	5	594	c.536C>G	c.(535-537)cCc>cGc	p.P179R	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124R|PPP2R1A_ENST00000462990.1_5'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612			Mis		clear cell ovarian carcinoma								31	42					0	0	1	0	0	G	52715971	C	G	52715971	3	3	49	1	0	0	0	0	1	0	0	0	12430	623	22	5	554	5	PPP2R1A	19	52715971	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	795495	52715971	6413012	64	9022										
ZNF671	79891	broad.mit.edu	37	chr19	58234684	58234684	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ttcccgagagaagtatacaaAcacatcctcaaagaccacac	5	13	1	2			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:58234684A>C	ENST00000317398.6	-	2	258	c.163T>G	c.(163-165)Ttt>Gtt	p.F55V	ZNF671_ENST00000596939.1_Intron|ZNF671_ENST00000594803.1_5'UTR|ZNF671_ENST00000335820.3_Intron|AC003006.7_ENST00000599221.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGTATACAAACACATCCTCA	0.458													5	186					0	0	1	0	0	C	58234684	A	C	58234684	3	2	49	1	0	0	0	0	1	0	0	0	18134	43	2	4	1453	4	ZNF671	19	58234684	Missense_Mutation	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08	5518713	58234684	894299	65	9023										
CDH26	60437	broad.mit.edu	37	chr20	58533811	58533811	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	agatccgggaggcacccctcGctgctgctgcttctagtgct	12	14	1	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr20:58533811G>C	ENST00000348616.4	+	1	330	c.30G>C	c.(28-30)tcG>tcC	p.S10S	CDH26_ENST00000244047.5_Silent_p.S10S	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	10					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GGCACCCCTCgctgctgctgc	0.587													23	57					0	0	1	0	0	C	58533811	G	C	58533811	2	2	49	1	0	0	0	0	0	0	0	1	3132	1074	38	5		5	CDH26	20	58533811	Silent	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08		58533811	4491709	66	9024										
USP25	29761	broad.mit.edu	37	chr21	17250147	17250147	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	caagccgcagaactcttcgaAtctggagaggatcgagaagt	12	9	2	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr21:17250147A>G	ENST00000285681.2	+	24	3297	c.2928A>G	c.(2926-2928)gaA>gaG	p.E976E	USP25_ENST00000285679.6_Silent_p.E944E|USP25_ENST00000351097.5_Silent_p.E339E|USP25_ENST00000400183.2_Silent_p.E1014E			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	944					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AACTCTTCGAATCTGGAGAGG	0.333													8	12					0	0	1	0	0	G	17250147	A	G	17250147	2	3	49	1	0	0	0	0	0	0	0	1	17115	98	4	4		4	USP25	21	17250147	Silent	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08		17250147	30879748	67	9025										
KRTAP20-2	337976	broad.mit.edu	37	chr21	32007616	32007616	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gcaactactatggtggtctgCgttatggctatggagtcctg	13	8	1	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr21:32007616C>T	ENST00000330798.2	+	1	62	c.34C>T	c.(34-36)Cgt>Tgt	p.R12C		NM_181616.1	NP_853647.1	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	12						intermediate filament				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|ovary(1)	8						TGGTGGTCTGCGTTATGGCTA	0.517													45	55					0	0	1	0	0	T	32007616	C	T	32007616	3	4	49	1	0	0	0	0	1	0	0	0	8579	768	27	1	36	1	KRTAP20-2	21	32007616	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	14757469	32007616	16122279	68	9026										
CNKSR2	22866	broad.mit.edu	37	chrX	21670532	21670532	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	acctcgaccttttcttggatAtctgtcaaaataccacctca	4	13	4	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:21670532A>G	ENST00000425654.2	+	21	3388	c.2908A>G	c.(2908-2910)Atc>Gtc	p.I970V	CNKSR2_ENST00000379510.3_Missense_Mutation_p.I1000V	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	1000					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TTTCTTGGATATCTGTCAAAA	0.398													40	31					0	0	1	0	0	G	21670532	A	G	21670532	3	3	49	1	0	0	0	0	1	0	0	0	3630	449	16	4	3093	4	CNKSR2	23	21670532	Missense_Mutation	SNP	A	TCGA-ND-A4WF-01A-11D-A28R-08		21670532	133600028	69	9027										
ZFX	7543	broad.mit.edu	37	chrX	24225888	24225888	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atcatggagttgaactgcttGatcagaacagcagtattcgt	10	7	2	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:24225888G>A	ENST00000379177.1	+	8	1283	c.856G>A	c.(856-858)Gat>Aat	p.D286N	ZFX_ENST00000459724.1_3'UTR|ZFX_ENST00000540034.1_Missense_Mutation_p.D325N|ZFX_ENST00000304543.5_Missense_Mutation_p.D286N|ZFX_ENST00000338565.3_Missense_Mutation_p.D236N|ZFX_ENST00000539115.1_Missense_Mutation_p.D57N|ZFX_ENST00000379188.3_Missense_Mutation_p.D286N	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						TGAACTGCTTGATCAGAACAG	0.408													28	65					0	0	1	0	0	A	24225888	G	A	24225888	3	1	49	1	0	0	0	0	1	0	0	0	17718	1290	45	3	870	3	ZFX	23	24225888	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	2555356	24225888	131044672	70	9028										
CYSLTR1	0	broad.mit.edu	37	chrX	77528817	77528817	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aatccaaatacctacacacaCaaacctggcttttttctgtg	4	12	1	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:77528817C>A	ENST00000373304.3	-	3	719	c.427G>T	c.(427-429)Gtg>Ttg	p.V143L		NM_006639.2	NP_006630.1	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	143					elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	CCTACACACACAAACCTGGCT	0.373													5	13					0.184627	0.186337	1	1	0	A	77528817	C	A	77528817	3	1	49	1	0	0	0	0	1	0	0	0	4224	478	17	5	590	5	CYSLTR1	23	77528817	Missense_Mutation	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	53302929	77528817	77741743	71	9029										
KLHL4	0	broad.mit.edu	37	chrX	86869493	86869493	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	aatgtttactaatgatgtgcTtgaagccaaacaagaagagg	10	5	0	4			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:86869493T>A	ENST00000373119.4	+	3	792	c.647T>A	c.(646-648)cTt>cAt	p.L216H	KLHL4_ENST00000373114.4_Missense_Mutation_p.L216H	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	216	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AATGATGTGCTTGAAGCCAAA	0.378													16	18					0	0	1	0	0	A	86869493	T	A	86869493	3	1	49	1	0	0	0	0	1	0	0	0	8433	1609	56	4	657	4	KLHL4	23	86869493	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	9340676	86869493	68401067	72	9030										
DIAPH2	1730	broad.mit.edu	37	chrX	95940099	95940099	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	gcgtcgggagcgggaggcggCagcgaggaacccggtggggg	24	9	0	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:95940099C>A	ENST00000324765.8	+	1	389	c.42C>A	c.(40-42)ggC>ggA	p.G14G	DIAPH2_ENST00000373054.4_Silent_p.G14G|DIAPH2_ENST00000373061.3_Silent_p.G14G|DIAPH2_ENST00000355827.4_Silent_p.G14G|DIAPH2_ENST00000373049.4_Silent_p.G14G			O60879	DIAP2_HUMAN	diaphanous-related formin 2	14					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						CGGGAGGCGGCAGCGAGGAAC	0.647													5	11					0.000602214	0.000631167	1	1	0	A	95940099	C	A	95940099	2	1	49	1	0	0	0	0	0	0	0	1	4547	697	25	5		5	DIAPH2	23	95940099	Silent	SNP	C	TCGA-ND-A4WF-01A-11D-A28R-08	9070606	95940099	59330461	73	9031										
GRIA3	2892	broad.mit.edu	37	chrX	122616806	122616806	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	tcacaaagaacacccaaaacTttaagcctgctcctgccacc	4	16	1	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:122616806T>C	ENST00000264357.5	+	15	2888	c.2596T>C	c.(2596-2598)Ttt>Ctt	p.F866L	GRIA3_ENST00000542149.1_3'UTR|GRIA3_ENST00000371256.5_Missense_Mutation_p.F866L|GRIA3_ENST00000371251.1_Missense_Mutation_p.F866L	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	866					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CACCCAAAACTTTAAGCCTGC	0.468													27	66					0	0	1	0	0	C	122616806	T	C	122616806	3	2	49	1	0	0	0	0	1	0	0	0	6809	1609	56	4	2773	4	GRIA3	23	122616806	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	26676707	122616806	32653754	74	9032										
MAGEC2	51438	broad.mit.edu	37	chrX	141291465	141291465	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ctccatgaaaaagaggagcaGcaggagctcagaggactctg	13	9	2	3			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:141291465G>C	ENST00000247452.3	-	3	656	c.309C>G	c.(307-309)tgC>tgG	p.C103W		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	103	Ser-rich.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGGAGCAGCAGGAGCTCA	0.562										HNSCC(46;0.14)			48	28					0	0	1	0	0	C	141291465	G	C	141291465	3	2	49	1	0	0	0	0	1	0	0	0	9230	963	34	5	816	5	MAGEC2	23	141291465	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	18674659	141291465	13979095	75	9033										
SPANXN3	139067	broad.mit.edu	37	chrX	142605155	142605155	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	atcttacctcatcattttttTtgttattggattcacagggg	7	7	4	0			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:142605155T>C	ENST00000370503.2	-	1	148	c.65A>G	c.(64-66)aAa>aGa	p.K22R		NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	22										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					ATCATTTTTTTTGTTATTGGA	0.453													5	121					0	0	1	0	0	C	142605155	T	C	142605155	3	2	49	1	0	0	0	0	1	0	0	0	15047	1841	64	4	368	4	SPANXN3	23	142605155	Missense_Mutation	SNP	T	TCGA-ND-A4WF-01A-11D-A28R-08	1313690	142605155	12665405	76	9034										
UBL4A	8266	broad.mit.edu	37	chrX	153714147	153714147	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.051948051948052	4	1	0.573913043478261	0.626086956521739	0.558401880141011	0.523809523809524	1	0	ggaccctgctggcatctgccGcactgaagtggcgggccaag	15	13	1	1			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:153714147G>A	ENST00000369660.4	-	3	411	c.326C>T	c.(325-327)gCg>gTg	p.A109V	UBL4A_ENST00000369653.4_Missense_Mutation_p.A109V|UBL4A_ENST00000477777.1_5'UTR	NM_014235.3	NP_055050.1	P11441	UBL4A_HUMAN	ubiquitin-like 4A	109					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity	p.A109V(1)		endometrium(5)|lung(1)|urinary_tract(1)	7	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCATCTGCCGCACTGAAGTG	0.622													62	111					0	0	1	0	0	A	153714147	G	A	153714147	3	1	49	1	0	0	0	0	1	0	0	0	16947	1087	38	1	155	1	UBL4A	23	153714147	Missense_Mutation	SNP	G	TCGA-ND-A4WF-01A-11D-A28R-08	11108992	153714147	1556413	77	9035										
ATP13A2	23400	broad.mit.edu	37	chr1	17320326	17320326	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	agccgtcctcagtgagggtgCccgtctgtgggagacaggtg	17	10	2	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr1:17320326C>A	ENST00000452699.1	-	16	1721	c.1532G>T	c.(1531-1533)gGc>gTc	p.G511V	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Missense_Mutation_p.G511V|ATP13A2_ENST00000326735.8_Missense_Mutation_p.G516V	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	516					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		AGTGAGGGTGCCCGTCTGTGG	0.692													3	9					0.004672	0.00475255	1	1	0	A	17320326	C	A	17320326	3	1	50	1	0	0	0	0	1	0	0	0	1123	739	26	5	2287	5	ATP13A2	1	17320326	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08		17320326	231930295	1	9036										
KLHDC7A	127707	broad.mit.edu	37	chr1	18809452	18809452	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	caggagcagcgctggtgggcCggccccaccgggggcagcaa	18	14	0	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr1:18809452C>T	ENST00000400664.1	+	1	2029	c.1977C>T	c.(1975-1977)gcC>gcT	p.A659A		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	659						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGGTGGGCCGGCCCCACCG	0.682													18	21					0	0	1	0	0	T	18809452	C	T	18809452	2	4	50	1	0	0	0	0	0	0	0	1	8402	639	23	1		1	KLHDC7A	1	18809452	Silent	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	1489126	18809452	230441169	2	9037										
KCNA3	3738	broad.mit.edu	37	chr1	111216299	111216299	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gcagccccttggagtggcgcGacagcttgaagatgcggaag	16	10	0	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr1:111216299G>A	ENST00000369769.2	-	1	1356	c.1133C>T	c.(1132-1134)tCg>tTg	p.S378L		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	378						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAGTGGCGCGACAGCTTGAA	0.592													68	144					0	0	1	0	0	A	111216299	G	A	111216299	3	1	50	1	0	0	0	0	1	0	0	0	8047	1059	37	1	598	1	KCNA3	1	111216299	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	92406847	111216299	138034322	3	9038										
RPTN	126638	broad.mit.edu	37	chr1	152128023	152128023	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	accatagtggaaactctggcCttgtctgtctgtctgaccat	9	11	4	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr1:152128023C>A	ENST00000316073.3	-	3	1616	c.1552G>T	c.(1552-1554)Ggc>Tgc	p.G518C		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	518	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						AAACTCTGGCCTTGTCTGTCT	0.498													379	665					1.76114e-179	2.0374e-179	1	1	0	A	152128023	C	A	152128023	3	1	50	1	0	0	0	0	1	0	0	0	13715	681	24	5	806	5	RPTN	1	152128023	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	40911724	152128023	97122598	4	9039										
PAPPA2	60676	broad.mit.edu	37	chr1	176738843	176738843	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	cccgtctttggtgaactatgCaaacttctcctgctcagagg	9	12	3	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr1:176738843C>A	ENST00000367662.3	+	16	5588	c.4424C>A	c.(4423-4425)gCa>gAa	p.A1475E		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1475	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTGAACTATGCAAACTTCTCC	0.517													38	73					2.05212e-20	2.32837e-20	1	1	0	A	176738843	C	A	176738843	3	1	50	1	0	0	0	0	1	0	0	0	11479	710	25	5	4535	5	PAPPA2	1	176738843	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	24610820	176738843	72511778	5	9040										
OR1C1	26188	broad.mit.edu	37	chr1	247921040	247921042	+	In_Frame_Del	DEL	GGA	GGA	-													0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gaggtgatcttcagaacagtGgagaagataagtccataaga							TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr1:247921040_247921042delGGA	ENST00000408896.2	-	1	940_942	c.667_669delTCC	c.(667-669)del	p.S223del		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCAGAACAGTGGAGAAGATAAGT	0.493													53	52	---	---	---	---						-	247921042	GGA	-	247921040	7	5	50	1	0	1	0	1	0	0	0	0	10999	1335	47	0	277	0	OR1C1	1	247921040	In_Frame_Del	DEL	GGA	TCGA-NF-A4WU-01A-11D-A28R-08	71182197	247921040	1329581	6	9041										
HECW2	57520	broad.mit.edu	37	chr2	197184313	197184313	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	tggacctctcagagcaggtcGctgtccccggcctggagtgg	15	13	1	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr2:197184313G>A	ENST00000260983.2	-	9	1483	c.1301C>T	c.(1300-1302)gCg>gTg	p.A434V	HECW2_ENST00000409111.1_Missense_Mutation_p.A78V	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	434					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AGAGCAGGTCGCTGTCCCCGG	0.502													26	65					0	0	1	0	0	A	197184313	G	A	197184313	3	1	50	1	0	0	0	0	1	0	0	0	7083	1087	38	1	3501	1	HECW2	2	197184313	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		197184313	46015060	7	9042										
PSMD2	5708	broad.mit.edu	37	chr3	184019846	184019846	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	atgcatatgcaaaggtctgcCtttatctcaccaggtgagtg	10	9	2	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr3:184019846C>G	ENST00000310118.4	+	5	1249	c.691C>G	c.(691-693)Ctt>Gtt	p.L231V	EIF2B5_ENST00000444495.1_Intron|PSMD2_ENST00000439383.1_Missense_Mutation_p.L101V|PSMD2_ENST00000435761.1_Missense_Mutation_p.L72V	NM_002808.3	NP_002799.3	Q13200	PSMD2_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	231					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|liver(1)|lung(12)|prostate(3)|upper_aerodigestive_tract(2)	27	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	AAAGGTCTGCCTTTATCTCAC	0.507													33	54					0	0	1	0	0	G	184019846	C	G	184019846	3	3	50	1	0	0	0	0	1	0	0	0	12746	681	24	5	709	5	PSMD2	3	184019846	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08		184019846	14002584	8	9043										
MUC4	4585	broad.mit.edu	37	chr3	195511815	195511815	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gtggatgctgaggaagggctGgtgacaggaagaggggtggc	22	4	0	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr3:195511815G>A	ENST00000463781.3	-	2	7095	c.6636C>T	c.(6634-6636)acC>acT	p.T2212T	MUC4_ENST00000475231.1_Silent_p.T2212T|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1001					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T2212T(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGGGCTGGTGACAGGAA	0.602													3	11					0	0	1	0	0	A	195511815	G	A	195511815	2	1	50	1	0	0	0	0	0	0	0	1	10025	1335	47	3		3	MUC4	3	195511815	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	11491969	195511815	2510615	9	9044										
MUC4	4585	broad.mit.edu	37	chr3	195511911	195511911	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gtggatgctgaggaagtgtcGgtgacaggaagagaggtggc	20	4	0	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr3:195511911G>A	ENST00000463781.3	-	2	6999	c.6540C>T	c.(6538-6540)acC>acT	p.T2180T	MUC4_ENST00000475231.1_Silent_p.T2180T|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	959					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T2180T(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGTGTCGGTGACAGGAA	0.587													3	6					0	0	1	0	0	A	195511911	G	A	195511911	2	1	50	1	0	0	0	0	0	0	0	1	10025	1103	39	1		1	MUC4	3	195511911	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	96	195511911	2510519	10	9045										
G3BP2	9908	broad.mit.edu	37	chr4	76571563	76571563	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	aactggttcagagtcatcaaAaaccacaaaaccaaaatttg	5	9	3	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr4:76571563A>G	ENST00000359707.4	-	11	1920	c.1135T>C	c.(1135-1137)Ttt>Ctt	p.F379L	G3BP2_ENST00000395719.3_Missense_Mutation_p.F379L|G3BP2_ENST00000357854.3_Missense_Mutation_p.F346L	NM_203505.2	NP_987101.1	Q9UN86	G3BP2_HUMAN	GTPase activating protein (SH3 domain) binding protein 2	379	RRM.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GAGTCATCAAAAACCACAAAA	0.328													19	137					0	0	1	0	0	G	76571563	A	G	76571563	3	3	50	1	0	0	0	0	1	0	0	0	6176	14	1	4	321	4	G3BP2	4	76571563	Missense_Mutation	SNP	A	TCGA-NF-A4WU-01A-11D-A28R-08		76571563	114582713	11	9046										
SLC6A3	6531	broad.mit.edu	37	chr5	1420693	1420693	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	actgtactcacagacgcctcGcagagccggtagaagtcaac	10	13	2	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr5:1420693G>A	ENST00000270349.9	-	6	1045	c.918C>T	c.(916-918)tgC>tgT	p.C306C	SLC6A3_ENST00000453492.2_Silent_p.C306C	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	306					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CAGACGCCTCGCAGAGCCGGT	0.592													58	109					0	0	1	0	0	A	1420693	G	A	1420693	2	1	50	1	0	0	0	0	0	0	0	1	14739	1079	38	1		1	SLC6A3	5	1420693	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		1420693	179494567	12	9047										
FAM173B	134145	broad.mit.edu	37	chr5	10227588	10227588	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	cagctggaaatgcatcgatgTacagggcctcttttcacggc	11	11	2	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr5:10227588T>G	ENST00000280330.8	-	6	781	c.175A>C	c.(175-177)Aca>Cca	p.T59P	FAM173B_ENST00000511437.1_Missense_Mutation_p.T223P|FAM173B_ENST00000510047.1_Missense_Mutation_p.T206P			Q6P4H8	F173B_HUMAN	family with sequence similarity 173, member B	223						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	16						TGCATCGATGTACAGGGCCTC	0.478													8	53					0	0	1	0	0	G	10227588	T	G	10227588	3	3	50	1	0	0	0	0	1	0	0	0	5523	1638	57	4	38	4	FAM173B	5	10227588	Missense_Mutation	SNP	T	TCGA-NF-A4WU-01A-11D-A28R-08	8806895	10227588	170687672	13	9048										
HIST1H4C	8364	broad.mit.edu	37	chr6	26104424	26104424	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gccaagcgcaaaactgtcacAgccatggatgtagtatatgc	10	10	1	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr6:26104424A>T	ENST00000377803.2	+	1	321	c.249A>T	c.(247-249)acA>acT	p.T83T		NM_003542.3	NP_003533.1	P62805	H4_HUMAN	histone cluster 1, H4c	83					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7						AAACTGTCACAGCCATGGATG	0.483													17	63					0	0	1	0	0	T	26104424	A	T	26104424	2	4	50	1	0	0	0	0	0	0	0	1	7207	175	7	4		4	HIST1H4C	6	26104424	Silent	SNP	A	TCGA-NF-A4WU-01A-11D-A28R-08		26104424	145010643	14	9049										
HIST1H1B	3009	broad.mit.edu	37	chr6	27834840	27834840	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gcgggcttcttcgccttcttCggagtcttcttcactgcctt	9	14	5	0	rs139479440	byFrequency	TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr6:27834840C>A	ENST00000331442.3	-	1	519	c.468G>T	c.(466-468)ccG>ccT	p.P156P		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	156					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						TCGCCTTCTTCGGAGTCTTCT	0.602													31	189					1.08312e-15	1.20574e-15	1	1	0	A	27834840	C	A	27834840	2	1	50	1	0	0	0	0	0	0	0	1	7163	871	31	2		2	HIST1H1B	6	27834840	Silent	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	1730416	27834840	143280227	15	9050										
OR12D3	81797	broad.mit.edu	37	chr6	29343055	29343055	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	aaactcattcattgtagtgaCattctccattgctctgggaa	7	9	4	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr6:29343055C>T	ENST00000396806.3	-	1	13	c.10G>A	c.(10-12)Gtc>Atc	p.V4I	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						ATTGTAGTGACATTCTCCATT	0.328													16	34					0	0	1	0	0	T	29343055	C	T	29343055	3	4	50	1	0	0	0	0	1	0	0	0	10979	478	17	3	944	3	OR12D3	6	29343055	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	1508215	29343055	141772012	16	9051										
DNAH11	8701	broad.mit.edu	37	chr7	21757423	21757423	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	agttggatagacagaaggcgGcatcaatcagaaaaggccaa	12	7	2	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr7:21757423G>A	ENST00000328843.6	+	44	7066	c.7035G>A	c.(7033-7035)cgG>cgA	p.R2345R	DNAH11_ENST00000409508.3_Silent_p.R2338R			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2345	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACAGAAGGCGGCATCAATCAG	0.378									Kartagener syndrome				9	45					0	0	1	0	0	A	21757423	G	A	21757423	2	1	50	1	0	0	0	0	0	0	0	1	4627	1190	42	3		3	DNAH11	7	21757423	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		21757423	137381240	17	9052										
MYO1G	64005	broad.mit.edu	37	chr7	45003662	45003662	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gctcaccgcctcaaggggcaCggcccgcatcacccggtact	11	18	3	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr7:45003662C>T	ENST00000258787.7	-	20	2867	c.2731G>A	c.(2731-2733)Gtg>Atg	p.V911M		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	911						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity	p.V911L(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						TCAAGGGGCACGGCCCGCATC	0.642													3	11					0	0	1	0	0	T	45003662	C	T	45003662	3	4	50	1	0	0	0	0	1	0	0	0	10121	536	19	1	337	1	MYO1G	7	45003662	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	23246239	45003662	114135001	18	9053										
ASNS	440	broad.mit.edu	37	chr7	97488687	97488687	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	cacttttaaaaagggagtcgCggagtgcttcaatgtaacaa	10	7	1	0	rs149193118		TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr7:97488687C>T	ENST00000175506.4	-	6	1039	c.511G>A	c.(511-513)Gcg>Acg	p.A171T	ASNS_ENST00000455086.1_Missense_Mutation_p.A88T|ASNS_ENST00000394308.3_Missense_Mutation_p.A171T|ASNS_ENST00000437628.1_Missense_Mutation_p.A88T|ASNS_ENST00000444334.1_Missense_Mutation_p.A150T|ASNS_ENST00000422745.1_Missense_Mutation_p.A150T|ASNS_ENST00000394309.3_Missense_Mutation_p.A171T	NM_183356.3	NP_899199.2	P08243	ASNS_HUMAN	asparagine synthetase (glutamine-hydrolyzing)	171	Glutamine amidotransferase type-2.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAGGGAGTCGCGGAGTGCTTC	0.368													13	36					0	0	1	0	0	T	97488687	C	T	97488687	3	4	50	1	0	0	0	0	1	0	0	0	1047	768	27	1	1210	1	ASNS	7	97488687	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	52485025	97488687	61649976	19	9054										
ASZ1	136991	broad.mit.edu	37	chr7	117067469	117067469	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	atcctcgctctcgctactctCgcctccgccagccactggca	7	20	2	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr7:117067469C>T	ENST00000284629.2	-	1	108	c.46G>A	c.(46-48)Gag>Aag	p.E16K		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	16					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity	p.E16K(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCGCTACTCTCGCCTCCGCCA	0.667											OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	79					0	0	1	0	0	T	117067469	C	T	117067469	3	4	50	1	0	0	0	0	1	0	0	0	1068	893	31	1	1433	1	ASZ1	7	117067469	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	19578782	117067469	42071194	20	9055										
DERL1	79139	broad.mit.edu	37	chr8	124037229	124037229	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	cacagactgaaggataccacGatgcaaatccagttaaagag	9	9	0	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr8:124037229G>T	ENST00000259512.4	-	3	627	c.327C>A	c.(325-327)atC>atA	p.I109I	DERL1_ENST00000405944.3_Silent_p.I109I|DERL1_ENST00000523036.1_Silent_p.I9I|DERL1_ENST00000419562.2_Intron|RP11-557C18.3_ENST00000521258.1_RNA|DERL1_ENST00000519018.1_Silent_p.I9I	NM_001134671.1|NM_024295.4	NP_001128143.1|NP_077271.1	Q9BUN8	DERL1_HUMAN	derlin 1	109					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	8	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AGGATACCACGATGCAAATCC	0.383													5	30					0.000602214	0.000634476	1	1	0	T	124037229	G	T	124037229	2	4	50	1	0	0	0	0	0	0	0	1	4474	1048	37	2		2	DERL1	8	124037229	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		124037229	22326793	21	9056										
NCBP1	4686	broad.mit.edu	37	chr9	100403882	100403882	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	agcaacctagaaggcttggcTggtgttttggaagctgatct	13	7	1	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr9:100403882T>A	ENST00000375147.3	+	3	418	c.162T>A	c.(160-162)gcT>gcA	p.A54A		NM_002486.4	NP_002477.1	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	54	MIF4G.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)	19		Acute lymphoblastic leukemia(62;0.158)				AAGGCTTGGCTGGTGTTTTGG	0.373													33	69					0	0	1	0	0	A	100403882	T	A	100403882	2	1	50	1	0	0	0	0	0	0	0	1	10257	1567	55	4		4	NCBP1	9	100403882	Silent	SNP	T	TCGA-NF-A4WU-01A-11D-A28R-08		100403882	40809549	22	9057										
ZNF462	58499	broad.mit.edu	37	chr9	109694600	109694600	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ggattggaagcagccaaagaCgccagtggcgccctggtggg	17	10	0	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr9:109694600C>T	ENST00000457913.1	+	5	6355	c.6066C>T	c.(6064-6066)gaC>gaT	p.D2022D	ZNF462_ENST00000277225.5_Intron|ZNF462_ENST00000441147.2_Silent_p.D868D|ZNF462_ENST00000497489.1_3'UTR	NM_021224.4	NP_067047.4	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2011					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CAGCCAAAGACGCCAGTGGCG	0.557													4	6					0	0	1	0	0	T	109694600	C	T	109694600	2	4	50	1	0	0	0	0	0	0	0	1	17982	551	19	1		1	ZNF462	9	109694600	Silent	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	9290718	109694600	31518831	23	9058										
LMX1B	4010	broad.mit.edu	37	chr9	129453154	129453154	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	agcggctgcatggagaagatCgcccccaccgagttcgtgat	13	12	0	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr9:129453154C>T	ENST00000355497.5	+	3	373	c.366C>T	c.(364-366)atC>atT	p.I122I	LMX1B_ENST00000373474.4_Silent_p.I122I|LMX1B_ENST00000526117.1_Silent_p.I122I|LMX1B_ENST00000561065.1_Silent_p.I99I|LMX1B_ENST00000425646.2_Silent_p.I99I	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	99	LIM zinc-binding 2.				dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						TGGAGAAGATCGCCCCCACCG	0.647									Nail-Patella Syndrome				15	24					0	0	1	0	0	T	129453154	C	T	129453154	2	4	50	1	0	0	0	0	0	0	0	1	8902	874	31	1		1	LMX1B	9	129453154	Silent	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	19758554	129453154	11760277	24	9059										
ARMC3	219681	broad.mit.edu	37	chr10	23292319	23292319	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	tcatcaagtaacataattaaCgatggattctatgattatgg	7	5	3	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr10:23292319C>T	ENST00000298032.5	+	13	1791	c.1707C>T	c.(1705-1707)aaC>aaT	p.N569N	ARMC3_ENST00000409049.3_Silent_p.N569N|ARMC3_ENST00000376528.4_Silent_p.N306N|ARMC3_ENST00000409983.3_Silent_p.N569N	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	569							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ACATAATTAACGATGGATTCT	0.323													19	95					0	0	1	0	0	T	23292319	C	T	23292319	2	4	50	1	0	0	0	0	0	0	0	1	951	535	19	1		1	ARMC3	10	23292319	Silent	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08		23292319	112242428	25	9060										
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"pancreatic, colorectal, lung, thyroid, AML, others"				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	9					0.00198382	0.00205343	1	1	0	A	25398284	C	A	25398284	3	1	50	1	0	0	0	0	1	0	0	0	8480	507	18	5	671	5	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08		25398284	108453611	26	9061										
OR9K2	441639	broad.mit.edu	37	chr12	55524043	55524043	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ctctgttcaaatgtccacacGtctgtgtactcagttggtgg	10	10	4	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr12:55524043G>A	ENST00000305377.5	+	1	579	c.491G>A	c.(490-492)cGt>cAt	p.R164H		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						ATGTCCACACGTCTGTGTACT	0.468													34	108					0	0	1	0	0	A	55524043	G	A	55524043	3	1	50	1	0	0	0	0	1	0	0	0	11300	1145	40	1	493	1	OR9K2	12	55524043	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	30125759	55524043	78327852	27	9062										
ERBB3	2065	broad.mit.edu	37	chr12	56478854	56478854	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	taccattgcccaacctccgcGtggtgcgagggacccaggtc	12	15	0	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr12:56478854G>A	ENST00000267101.3	+	3	750	c.310G>A	c.(310-312)Gtg>Atg	p.V104M	ERBB3_ENST00000411731.2_Missense_Mutation_p.V104M|ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.V45M	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	104			V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(7)|p.V104L(2)		central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517													75	161					0	0	1	0	0	A	56478854	G	A	56478854	3	1	50	1	0	0	0	0	1	0	0	0	5236	1145	40	1	320	1	ERBB3	12	56478854	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	954811	56478854	77373041	28	9063										
ERBB3	2065	broad.mit.edu	37	chr12	56492632	56492632	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	cagacctgctagagaaggggGagcggttggcacagccccag	16	11	0	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr12:56492632G>A	ENST00000267101.3	+	23	3222	c.2782G>A	c.(2782-2784)Gag>Aag	p.E928K	ERBB3_ENST00000549832.1_Missense_Mutation_p.E48K|ERBB3_ENST00000450146.2_Missense_Mutation_p.E285K|ERBB3_ENST00000415288.2_Missense_Mutation_p.E869K|ERBB3_ENST00000553131.1_Missense_Mutation_p.E169K	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	928	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGAGAAGGGGGAGCGGTTGGC	0.512													49	138					0	0	1	0	0	A	56492632	G	A	56492632	3	1	50	1	0	0	0	0	1	0	0	0	5236	1175	41	3	3003	3	ERBB3	12	56492632	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	13778	56492632	77359263	29	9064										
NACA	4666	broad.mit.edu	37	chr12	57114545	57114545	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gcttcctgggttttgtggagAaatcagaactgaggaaatgg	14	5	1	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr12:57114545A>C	ENST00000454682.1	-	3	1050	c.769T>G	c.(769-771)Tct>Gct	p.S257A	NACA_ENST00000393891.4_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.S257A|NACA_ENST00000551793.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000546392.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding	p.S257P(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TTTTGTGGAGAAATCAGAACT	0.512			T	BCL6	NHL								63	55					0	0	1	0	0	C	57114545	A	C	57114545	3	2	50	1	0	0	0	0	1	0	0	0	10180	246	9	4	5495	4	NACA	12	57114545	Missense_Mutation	SNP	A	TCGA-NF-A4WU-01A-11D-A28R-08	621913	57114545	76737350	30	9065										
FSCB	84075	broad.mit.edu	37	chr14	44976102	44976102	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ttccagaagtattaccaataCgatgggtagctttggggcta	11	7	0	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr14:44976102C>T	ENST00000340446.4	-	1	380	c.89G>A	c.(88-90)cGt>cAt	p.R30H		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	30						cilium		p.R30H(1)		breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		ATTACCAATACGATGGGTAGC	0.428													22	115					0	0	1	0	0	T	44976102	C	T	44976102	3	4	50	1	0	0	0	0	1	0	0	0	6100	536	19	1	2392	1	FSCB	14	44976102	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08		44976102	62373438	31	9066										
SAV1	60485	broad.mit.edu	37	chr14	51101951	51101951	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ccactgctgtctctgctttcGgttttccaactctgtaagaa	7	12	2	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr14:51101951G>A	ENST00000324679.4	-	5	1465	c.1102C>T	c.(1102-1104)Cga>Tga	p.R368*		NM_021818.3	NP_068590.1	Q9H4B6	SAV1_HUMAN	salvador homolog 1 (Drosophila)	368	SARAH.				hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					CTCTGCTTTCGGTTTTCCAAC	0.343													23	34					0	0	1	0	0	A	51101951	G	A	51101951	4	1	50	1	0	0	0	0	0	1	0	0	13908	1124	39	1	53	1	SAV1	14	51101951	Nonsense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	6125849	51101951	56247589	32	9067										
MAN2A2	4122	broad.mit.edu	37	chr15	91455346	91455346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gctgggcctggatgggcaccGcacgctgccctcctctgtgc	14	16	1	0	rs146996561		TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr15:91455346G>A	ENST00000360468.3	+	14	2201	c.2183G>A	c.(2182-2184)cGc>cAc	p.R728H	MAN2A2_ENST00000559717.1_Missense_Mutation_p.R728H|MAN2A2_ENST00000431652.2_Missense_Mutation_p.R236H	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	728					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GATGGGCACCGCACGCTGCCC	0.667													56	58					0	0	1	0	0	A	91455346	G	A	91455346	3	1	50	1	0	0	0	0	1	0	0	0	9264	1087	38	1	2237	1	MAN2A2	15	91455346	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		91455346	11076046	33	9068										
ABCA3	21	broad.mit.edu	37	chr16	2331468	2331468	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ggtcctctcgtccgctacatCttggtcctcaggaagcacag	10	14	3	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr16:2331468C>T	ENST00000301732.5	-	27	4778	c.4078G>A	c.(4078-4080)Gat>Aat	p.D1360N	ABCA3_ENST00000382381.3_Missense_Mutation_p.D1302N	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1360					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TCCGCTACATCTTGGTCCTCA	0.582													10	98					0	0	1	0	0	T	2331468	C	T	2331468	3	4	50	1	0	0	0	0	1	0	0	0	33	913	32	3	1064	3	ABCA3	16	2331468	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08		2331468	88023285	34	9069										
SRRM2	23524	broad.mit.edu	37	chr16	2812318	2812318	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ccaggcggagatcacgatccAgaactcccaccaggcgtagg	12	14	1	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr16:2812318A>G	ENST00000301740.8	+	11	2338	c.1789A>G	c.(1789-1791)Aga>Gga	p.R597G		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	597	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						ATCACGATCCAGAACTCCCAC	0.617													23	57					0	0	1	0	0	G	2812318	A	G	2812318	3	3	50	1	0	0	0	0	1	0	0	0	15224	180	7	4	1827	4	SRRM2	16	2812318	Missense_Mutation	SNP	A	TCGA-NF-A4WU-01A-11D-A28R-08	480850	2812318	87542435	35	9070										
PKD1L2	114780	broad.mit.edu	37	chr16	81197274	81197274	+	RNA	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ctggtcacacggaggccaccGacagtcccgctgacatcaaa	10	15	2	1			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr16:81197274G>A	ENST00000525539.1	-	0	3407				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GGAGGCCACCGACAGTCCCGC	0.532													5	12					0	0	1	0	0	A	81197274	G	A	81197274	1	1	50	0	1	0	0	0	0	0	0	0	12012	1045	37	1		1	PKD1L2	16	81197274	RNA	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	78384956	81197274	9157479	36	9071										
TP53	7157	broad.mit.edu	37	chr17	7578272	7578272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	tccttccactcggataagatGctgaggaggggccagaccta	12	11	0	3			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr17:7578272G>A	ENST00000420246.2	-	6	709	c.577C>T	c.(577-579)Cat>Tat	p.H193Y	TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Missense_Mutation_p.H193Y|TP53_ENST00000359597.4_Missense_Mutation_p.H193Y|TP53_ENST00000269305.4_Missense_Mutation_p.H193Y|TP53_ENST00000445888.2_Missense_Mutation_p.H193Y|TP53_ENST00000455263.2_Missense_Mutation_p.H193Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193Y(29)|p.H193D(13)|p.0?(8)|p.?(6)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.H61D(2)|p.H100D(2)|p.P191fs*15(1)|p.H61Y(1)|p.P191fs*6(1)|p.H100Y(1)|p.P98_E105>Q(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGATAAGATGCTGAGGAGGG	0.557		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	22					0	0	1	0	0	A	7578272	G	A	7578272	3	1	50	1	0	0	0	0	1	0	0	0	16441	1319	46	3	717	3	TP53	17	7578272	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		7578272	73616938	37	9072										
NF1	4763	broad.mit.edu	37	chr17	29687566	29687566	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	tcttgatgccttgattgacaCgtacctgcctggaattgatg	10	9	1	4	rs144178015		TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr17:29687566C>G	ENST00000358273.4	+	57	8605	c.8222C>G	c.(8221-8223)aCg>aGg	p.T2741R	NF1_ENST00000356175.3_Missense_Mutation_p.T2720R|NF1_ENST00000444181.2_Missense_Mutation_p.T534R|NF1_ENST00000417592.2_3'UTR	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2741					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTGATTGACACGTACCTGCCT	0.418			"D, Mis, N, F, S, O"		"neurofibroma, glioma"	"neurofibroma, glioma"			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			15	143					0	0	1	0	0	G	29687566	C	G	29687566	3	3	50	1	0	0	0	0	1	0	0	0	10402	536	19	5	8509	5	NF1	17	29687566	Missense_Mutation	SNP	C	TCGA-NF-A4WU-01A-11D-A28R-08	22109294	29687566	51507644	38	9073										
SUZ12	23512	broad.mit.edu	37	chr17	30293184	30293184	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	agcttgtcagctcatttgcaGcttacgtttactggtttctt	8	9	3	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr17:30293184G>A	ENST00000322652.5	+	5	703	c.474G>A	c.(472-474)caG>caA	p.Q158Q	SUZ12_ENST00000580398.1_Silent_p.Q135Q	NM_015355.2	NP_056170.2	Q15022	SUZ12_HUMAN	SUZ12 polycomb repressive complex 2 subunit	158					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		SSH2/SUZ12(2)|JAZF1/SUZ12(133)	breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(5)|skin(1)	21		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				CTCATTTGCAGCTTACGTTTA	0.269			T	JAZF1	endometrial stromal tumours								3	11					0	0	1	0	0	A	30293184	G	A	30293184	2	1	50	1	0	0	0	0	0	0	0	1	15471	962	34	3		3	SUZ12	17	30293184	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	605618	30293184	50902026	39	9074										
ZNF585A	199704	broad.mit.edu	37	chr19	37643369	37643369	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	atgtgtaatgagatttgaccGgttggtgaatgccttcccac	11	8	0	3	rs143272721	byFrequency	TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr19:37643369G>T	ENST00000356958.4	-	5	1690	c.1432C>A	c.(1432-1434)Cgg>Agg	p.R478R	ZNF585A_ENST00000292841.5_Silent_p.R423R|ZNF585A_ENST00000355533.2_Intron|ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000392157.2_Silent_p.R423R			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGATTTGACCGGTTGGTGAAT	0.403													15	104					9.16793e-09	1.00168e-08	1	1	0	T	37643369	G	T	37643369	2	4	50	1	0	0	0	0	0	0	0	1	18073	1115	39	5		5	ZNF585A	19	37643369	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		37643369	21485614	40	9075										
BAGE2	85319	broad.mit.edu	37	chr21	11089518	11089519	+	RNA	INS	-	-	A													0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	acagagcgagactctgtctcINSaaaaaaacagaaacaaacga							TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chr21:11089518_11089519insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gactctgtctcaaaaaaacaga	0.48													2	4	---	---	---	---						A	11089519	-	A	11089518	6	5	50	0	1	1	1	0	0	0	0	0	1290	841	29	0		0	BAGE2	21	11089518	RNA	INS	-	TCGA-NF-A4WU-01A-11D-A28R-08		11089518	37040377	41	9076										
PJA1	64219	broad.mit.edu	37	chrX	68382933	68382933	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	gcattgggacttcggagttcGtctttctctggctggcaatc	12	10	2	0	rs147196192		TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chrX:68382933G>A	ENST00000361478.1	-	2	526	c.149C>T	c.(148-150)aCg>aTg	p.T50M	PJA1_ENST00000374571.4_De_novo_Start_InFrame|PJA1_ENST00000374583.1_Missense_Mutation_p.T50M|PJA1_ENST00000374584.3_Missense_Mutation_p.T50M|PJA1_ENST00000477231.1_5'UTR	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	50							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						TTCGGAGTTCGTCTTTCTCTG	0.537													41	116					0	0	1	0	0	A	68382933	G	A	68382933	3	1	50	1	0	0	0	0	1	0	0	0	12008	1145	40	1	1786	1	PJA1	23	68382933	Missense_Mutation	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08		68382933	86887627	42	9077										
ESX1	80712	broad.mit.edu	37	chrX	103499131	103499131	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	ccaccctcacggtcttggtcGtccgaggggacggacccttc	12	16	2	0			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chrX:103499131G>A	ENST00000372588.4	-	2	293	c.210C>T	c.(208-210)gaC>gaT	p.D70D		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	70					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.D70D(1)		endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GGTCTTGGTCGTCCGAGGGGA	0.652													6	244					0	0	1	0	0	A	103499131	G	A	103499131	2	1	50	1	0	0	0	0	0	0	0	1	5291	1136	40	1		1	ESX1	23	103499131	Silent	SNP	G	TCGA-NF-A4WU-01A-11D-A28R-08	35116198	103499131	51771429	43	9078										
FGF13	2258	broad.mit.edu	37	chrX	137717785	137717785	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0227272727272727	1	1	0.273126463700234	0	0.294136191677175	1	1	0	aataattttcaaacactgatTctttgaatttgcactcaggt	5	7	3	2			TCGA-NF-A4WU-01A-11D-A28R-08	TCGA-NF-A4WU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6090017-f654-44df-a9f1-de8cebd17800	70bbf359-1999-4ac8-9cda-79d8abdebad0	g.chrX:137717785T>A	ENST00000315930.6	-	4	1095	c.434A>T	c.(433-435)gAa>gTa	p.E145V	FGF13_ENST00000541469.1_Missense_Mutation_p.E99V|FGF13_ENST00000441825.2_Missense_Mutation_p.E126V|FGF13_ENST00000370603.3_Missense_Mutation_p.E155V|FGF13_ENST00000305414.4_Missense_Mutation_p.E92V	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	145					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					AAACACTGATTCTTTGAATTT	0.373													14	35					0	0	1	0	0	A	137717785	T	A	137717785	3	1	50	1	0	0	0	0	1	0	0	0	5874	1783	62	4	311	4	FGF13	23	137717785	Missense_Mutation	SNP	T	TCGA-NF-A4WU-01A-11D-A28R-08	34218654	137717785	17552775	44	9079										
CPSF3L	54973	broad.mit.edu	37	chr1	1256383	1256383	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ccaagggactcacgtcgtcaTtgaagcccatgtgcattcca	9	13	2	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr1:1256383T>C	ENST00000540437.1	-	4	592	c.137A>G	c.(136-138)aAt>aGt	p.N46S	CPSF3L_ENST00000435064.1_Missense_Mutation_p.N40S|CPSF3L_ENST00000411962.1_Intron|CPSF3L_ENST00000421495.2_Intron|CPSF3L_ENST00000450926.2_Missense_Mutation_p.N40S|CPSF3L_ENST00000419704.1_Missense_Mutation_p.N40S|CPSF3L_ENST00000545578.1_Missense_Mutation_p.N11S	NM_001256456.1	NP_001243385.1	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor 3-like	40						Golgi apparatus|nucleus	hydrolase activity			endometrium(4)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(3)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		CACGTCGTCATTGAAGCCCAT	0.652													27	64					0	0	1	0	0	C	1256383	T	C	1256383	3	2	51	1	0	0	0	0	1	0	0	0	3850	1493	52	4	1747	4	CPSF3L	1	1256383	Missense_Mutation	SNP	T	TCGA-NF-A4WX-01A-11D-A28R-08		1256383	247994238	1	9080										
CD1E	913	broad.mit.edu	37	chr1	158325665	158325665	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ccccagtcctggccctggccGtctgcagcttgtgtgccatg	12	16	1	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr1:158325665G>A	ENST00000444681.2	+	3	670	c.377G>A	c.(376-378)cGt>cAt	p.R126H	CD1E_ENST00000434258.1_Missense_Mutation_p.R223H|CD1E_ENST00000368166.3_Missense_Mutation_p.R36H|CD1E_ENST00000368160.3_Missense_Mutation_p.R225H|CD1E_ENST00000368163.3_Missense_Mutation_p.R225H|CD1E_ENST00000368156.1_Missense_Mutation_p.R135H|CD1E_ENST00000368154.1_Missense_Mutation_p.R36H|CD1E_ENST00000368165.3_Missense_Mutation_p.R135H|CD1E_ENST00000368155.3_Missense_Mutation_p.R135H|CD1E_ENST00000368161.3_Missense_Mutation_p.R225H|CD1E_ENST00000368157.1_Missense_Mutation_p.R36H|CD1E_ENST00000368164.3_Missense_Mutation_p.R36H|CD1E_ENST00000368167.3_Missense_Mutation_p.R225H|CD1E_ENST00000452291.2_Missense_Mutation_p.R36H	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	225					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GGCCCTGGCCGTCTGCAGCTT	0.592													44	51					0	0	1	0	0	A	158325665	G	A	158325665	3	1	51	1	0	0	0	0	1	0	0	0	3000	1145	40	1	688	1	CD1E	1	158325665	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	157069282	158325665	90924956	2	9081										
KLHL20	27252	broad.mit.edu	37	chr1	173743491	173743491	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tcgggtagcttctatgagtaCcagaagactaggtgtggctg	14	7	1	3			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr1:173743491C>G	ENST00000209884.4	+	9	1479	c.1343C>G	c.(1342-1344)aCc>aGc	p.T448S	KLHL20_ENST00000546011.1_Missense_Mutation_p.T259S	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	448					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						TCTATGAGTACCAGAAGACTA	0.488													6	210					0	0	1	0	0	G	173743491	C	G	173743491	3	3	51	1	0	0	0	0	1	0	0	0	8417	507	18	5	1373	5	KLHL20	1	173743491	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	15417826	173743491	75507130	3	9082										
DHX57	90957	broad.mit.edu	37	chr2	39050325	39050325	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gtaatcgtatttttgaggcaCgaagagaatcggtgtgtgga	14	4	0	2	rs146225438		TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr2:39050325C>T	ENST00000295373.6	-	17	3227	c.3101G>A	c.(3100-3102)cGt>cAt	p.R1034H		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1034							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TTTTGAGGCACGAAGAGAATC	0.428													17	42					0	0	1	0	0	T	39050325	C	T	39050325	3	4	51	1	0	0	0	0	1	0	0	0	4541	536	19	1	1091	1	DHX57	2	39050325	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		39050325	204149048	4	9083										
KYNU	8942	broad.mit.edu	37	chr2	143798178	143798178	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ccagctaacaataacattttCtgttccaaacaaagatgttt	4	9	1	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr2:143798178C>T	ENST00000264170.4	+	13	1481	c.1223C>T	c.(1222-1224)tCt>tTt	p.S408F	KYNU_ENST00000409512.1_Missense_Mutation_p.S408F	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	408					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ATAACATTTTCTGTTCCAAAC	0.408													6	26					0	0	1	0	0	T	143798178	C	T	143798178	3	4	51	1	0	0	0	0	1	0	0	0	8625	913	32	3	1295	3	KYNU	2	143798178	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	104747853	143798178	99401195	5	9084										
PLA2R1	0	broad.mit.edu	37	chr2	160807932	160807932	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	aaggactggtgatactggtcTgtgatgctgaccagttgtgc	14	7	1	3			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr2:160807932T>C	ENST00000283243.7	-	24	3665	c.3459A>G	c.(3457-3459)acA>acG	p.T1153T	PLA2R1_ENST00000392771.1_Silent_p.T1153T	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	1153	C-type lectin 7.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GATACTGGTCTGTGATGCTGA	0.433													17	31					0	0	1	0	0	C	160807932	T	C	160807932	2	2	51	1	0	0	0	0	0	0	0	1	12057	1567	55	4		4	PLA2R1	2	160807932	Silent	SNP	T	TCGA-NF-A4WX-01A-11D-A28R-08	17009754	160807932	82391441	6	9085										
CX3CR1	1524	broad.mit.edu	37	chr3	39307306	39307306	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cgatgaccaccagaaggatcAgtttaatggctttggctttc	10	9	1	2			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr3:39307306A>C	ENST00000541347.1	-	2	934	c.695T>G	c.(694-696)cTg>cGg	p.L232R	CX3CR1_ENST00000358309.3_Missense_Mutation_p.L264R|CX3CR1_ENST00000542107.1_Missense_Mutation_p.L232R|CX3CR1_ENST00000399220.2_Missense_Mutation_p.L232R	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	232					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CAGAAGGATCAGTTTAATGGC	0.448													5	61					0	0	1	0	0	C	39307306	A	C	39307306	3	2	51	1	0	0	0	0	1	0	0	0	4098	188	7	4	376	4	CX3CR1	3	39307306	Missense_Mutation	SNP	A	TCGA-NF-A4WX-01A-11D-A28R-08		39307306	158715124	7	9086										
COL6A6	131873	broad.mit.edu	37	chr3	130383937	130383937	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gcagcccccacgaccattccGaaggtactgtctgtttggtg	11	13	1	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr3:130383937G>A	ENST00000358511.6	+	35	6624	c.6593G>A	c.(6592-6594)cGa>cAa	p.R2198Q	COL6A6_ENST00000453409.2_Missense_Mutation_p.R2198Q	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2198	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CGACCATTCCGAAGGTACTGT	0.413													4	5					0	0	1	0	0	A	130383937	G	A	130383937	3	1	51	1	0	0	0	0	1	0	0	0	3726	1058	37	1	6731	1	COL6A6	3	130383937	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	91076631	130383937	67638493	8	9087										
FBXW7	0	broad.mit.edu	37	chr4	153249385	153249385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ttcatgaagatgcatacaacGcacagtggaagtatgcccat	9	9	1	2			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr4:153249385G>A	ENST00000281708.4	-	9	2622	c.1393C>T	c.(1393-1395)Cgt>Tgt	p.R465C	FBXW7_ENST00000603548.1_Missense_Mutation_p.R465C|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289C|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385C|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465C|FBXW7_ENST00000296555.5_Missense_Mutation_p.R347C	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465C(71)|p.R226C(11)|p.R385C(11)|p.R347C(3)|p.R465Y(2)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCATACAACGCACAGTGGAA	0.413			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								58	32					0	0	1	0	0	A	153249385	G	A	153249385	3	1	51	1	0	0	0	0	1	0	0	0	5801	1087	38	1	746	1	FBXW7	4	153249385	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08		153249385	37904891	9	9088										
SPCS3	60559	broad.mit.edu	37	chr4	177241254	177241254	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	acggtgctgtcgcgggcgaaCtcactgttcgccttctcgct	12	14	2	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr4:177241254C>G	ENST00000503362.1	+	1	140	c.27C>G	c.(25-27)aaC>aaG	p.N9K	RP11-87F15.2_ENST00000512634.1_RNA	NM_021928.3	NP_068747.1	P61009	SPCS3_HUMAN	signal peptidase complex subunit 3 homolog (S. cerevisiae)	9					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			ovary(2)	2		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.43e-19)|Epithelial(43;1.84e-16)|OV - Ovarian serous cystadenocarcinoma(60;4.51e-09)|GBM - Glioblastoma multiforme(59;0.000142)|STAD - Stomach adenocarcinoma(60;0.00279)|LUSC - Lung squamous cell carcinoma(193;0.0319)		CGCGGGCGAACTCACTGTTCG	0.672													52	67					0	0	1	0	0	G	177241254	C	G	177241254	3	3	51	1	0	0	0	0	1	0	0	0	15080	564	20	5	29	5	SPCS3	4	177241254	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	23991869	177241254	13913022	10	9089										
MARCH6	10299	broad.mit.edu	37	chr5	10403623	10403623	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ggaatggtatatgtcttctaCtttgcctccttcattctact	6	10	4	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr5:10403623C>T	ENST00000274140.5	+	15	1434	c.1302C>T	c.(1300-1302)taC>taT	p.Y434Y	MARCH6_ENST00000503788.1_Silent_p.Y329Y|MARCH6_ENST00000510792.1_Silent_p.Y132Y|MARCH6_ENST00000449913.2_Silent_p.Y386Y	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	434					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						ATGTCTTCTACTTTGCCTCCT	0.428													34	26					0	0	1	0	0	T	10403623	C	T	10403623	2	4	51	1	0	0	0	0	0	0	0	1	9354	576	20	3		3	MARCH6	5	10403623	Silent	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		10403623	170511637	11	9090										
PCDHA1	0	broad.mit.edu	37	chr5	140166141	140166141	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cattttgtttgtgaattctcGgatcgatcgcgaggagctgt	12	7	1	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr5:140166141G>A	ENST00000504120.2	+	1	266	c.266G>A	c.(265-267)cGg>cAg	p.R89Q	PCDHA1_ENST00000378133.3_Missense_Mutation_p.R89Q|PCDHA1_ENST00000394633.3_Missense_Mutation_p.R89Q	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAATTCTCGGATCGATCGC	0.582													4	152					0	0	1	0	0	A	140166141	G	A	140166141	3	1	51	1	0	0	0	0	1	0	0	0	11565	1116	39	1	268	1	PCDHA1	5	140166141	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	129762518	140166141	40749119	12	9091										
HFE	3077	broad.mit.edu	37	chr6	26091203	26091203	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	agagtcgccgtgtggagcccCgaactccatgggtttccagt	13	12	0	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr6:26091203C>T	ENST00000357618.5	+	2	333	c.211C>T	c.(211-213)Cga>Tga	p.R71*	HFE_ENST00000317896.7_Nonsense_Mutation_p.R71*|HFE_ENST00000461397.1_Nonsense_Mutation_p.R71*|HFE_ENST00000309234.6_Nonsense_Mutation_p.R71*|HFE_ENST00000470149.1_Nonsense_Mutation_p.R71*|HFE_ENST00000336625.8_Nonsense_Mutation_p.R71*|HFE_ENST00000349999.4_Intron|HFE_ENST00000397022.3_Nonsense_Mutation_p.R48*|HFE_ENST00000488199.1_Intron|HFE_ENST00000352392.4_Intron|HFE_ENST00000353147.5_Intron	NM_000410.3|NM_139006.2	NP_000401.1|NP_620575.1	Q30201	HFE_HUMAN	hemochromatosis	71	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding	p.R71R(1)		endometrium(3)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGTGGAGCCCCGAACTCCATG	0.512									Hemochromatosis				46	57					0	0	1	0	0	T	26091203	C	T	26091203	4	4	51	1	0	0	0	0	0	1	0	0	7121	644	23	1	217	1	HFE	6	26091203	Nonsense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		26091203	145023864	13	9092										
USP49	25862	broad.mit.edu	37	chr6	41774205	41774205	+	Frame_Shift_Del	DEL	G	G	-													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ctccagggcctcctcctgccGccgctgctccagcttcgcct							TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr6:41774205delG	ENST00000394253.3	-	3	846	c.517delC	c.(517-519)ggfs	p.R173fs	USP49_ENST00000373009.3_Frame_Shift_Del_p.R173fs|USP49_ENST00000373006.1_Frame_Shift_Del_p.R173fs|USP49_ENST00000373010.1_Frame_Shift_Del_p.R173fs|USP49_ENST00000297229.2_Frame_Shift_Del_p.R173fs			Q70CQ1	UBP49_HUMAN	ubiquitin specific peptidase 49	173					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)|skin(2)	23	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TCCTCCTGCCGCCGCTGCTCC	0.731													11	10	---	---	---	---						-	41774205	G	-	41774205	7	5	51	1	0	1	0	1	0	0	0	0	17139	1086	38	0	1421	0	USP49	6	41774205	Frame_Shift_Del	DEL	G	TCGA-NF-A4WX-01A-11D-A28R-08	15683002	41774205	129340862	14	9093										
WIPF3	644150	broad.mit.edu	37	chr7	29923822	29923822	+	Frame_Shift_Del	DEL	C	C	-													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ccccaacgccacccccgctgCccccggcctcggttcttagt							TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr7:29923822delC	ENST00000409290.1	+	4	712	c.712delC	c.(712-714)ccfs	p.P239fs	WIPF3_ENST00000242140.5_Frame_Shift_Del_p.P239fs|WIPF3_ENST00000409123.1_Frame_Shift_Del_p.P239fs	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	239										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						acccccgctgcccccggcctc	0.706													2	4	---	---	---	---						-	29923822	C	-	29923822	7	5	51	1	0	1	0	1	0	0	0	0	17428	739	26	0	726	0	WIPF3	7	29923822	Frame_Shift_Del	DEL	C	TCGA-NF-A4WX-01A-11D-A28R-08		29923822	129214841	15	9094										
RNF32	140545	broad.mit.edu	37	chr7	156447342	156447342	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	atgggagaaggtgaaacagcGctctctcctgcaaggggact	14	9	1	2			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr7:156447342G>A	ENST00000392741.2	+	3	435	c.347G>A	c.(346-348)cGc>cAc	p.R116H	RNF32_ENST00000392743.2_Missense_Mutation_p.R116H|RNF32_ENST00000480011.1_3'UTR|RNF32_ENST00000343665.4_Missense_Mutation_p.R116H|AC005534.8_ENST00000455709.1_RNA|RNF32_ENST00000317955.5_Missense_Mutation_p.R116H|RNF32_ENST00000432459.2_Missense_Mutation_p.R116H|RNF32_ENST00000311822.8_Missense_Mutation_p.R116H|RNF32_ENST00000405335.1_Missense_Mutation_p.R116H			Q9H0A6	RNF32_HUMAN	ring finger protein 32	116						aggresome|endosome	protein binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(2)	15	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GTGAAACAGCGCTCTCTCCTG	0.527													6	50					0	0	1	0	0	A	156447342	G	A	156447342	3	1	51	1	0	0	0	0	1	0	0	0	13539	1087	38	1	357	1	RNF32	7	156447342	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	126523520	156447342	2691321	16	9095										
NAT2	10	broad.mit.edu	37	chr8	18258041	18258041	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	attacaaacaaagaatttctTaattctcatctcctgccaaa	2	10	3	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr8:18258041T>A	ENST00000286479.3	+	2	635	c.528T>A	c.(526-528)ctT>ctA	p.L176L	NAT2_ENST00000520116.1_Silent_p.L46L	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	176					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		AAGAATTTCTTAATTCTCATC	0.383									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				7	54					0	0	1	0	0	A	18258041	T	A	18258041	2	1	51	1	0	0	0	0	0	0	0	1	10224	1741	61	4		4	NAT2	8	18258041	Silent	SNP	T	TCGA-NF-A4WX-01A-11D-A28R-08		18258041	128105981	17	9096										
VPS13B	157680	broad.mit.edu	37	chr8	100287482	100287482	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ttgactactgccacaattccGgtaagtacaaacctatcatt	5	11	1	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr8:100287482G>T	ENST00000395996.1	+	19	2935	c.2824_splice	c.e19+1	p.G942_splice	VPS13B_ENST00000357162.2_Splice_Site_p.G942_splice|VPS13B_ENST00000358544.2_Splice_Site_p.G942_splice			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	942					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCACAATTCCGGTAAGTACAA	0.333													17	71					4.7546e-09	5.18684e-09	1	1	0	T	100287482	G	T	100287482	5	4	51	1	0	0	0	0	0	0	1	0	17249	1130	39	5	3017	5	VPS13B	8	100287482	Splice_Site	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	82029441	100287482	46076540	18	9097										
MTBP	27085	broad.mit.edu	37	chr8	121531025	121531025	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gtttcactgcatgcagccagCgtctctttgaaatctctaag	8	11	3	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr8:121531025C>T	ENST00000305949.1	+	20	2623	c.2578C>T	c.(2578-2580)Cgt>Tgt	p.R860C		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	860	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			ATGCAGCCAGCGTCTCTTTGA	0.353													37	14					0	0	1	0	0	T	121531025	C	T	121531025	3	4	51	1	0	0	0	0	1	0	0	0	9959	768	27	1	2656	1	MTBP	8	121531025	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	21243543	121531025	24832997	19	9098										
WAC	51322	broad.mit.edu	37	chr10	28822965	28822965	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ggactcgcagccttaccaggTaccagccgaggccggggtgg	16	13	0	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr10:28822965T>A	ENST00000375664.3	+	2	552		c.e2+2		WAC_ENST00000532233.1_Splice_Site|WAC_ENST00000354911.4_Splice_Site|WAC_ENST00000347934.4_Splice_Site|WAC_ENST00000375646.1_Splice_Site|WAC_ENST00000428935.1_Splice_Site			Q9BTA9	WAC_HUMAN	WW domain containing adaptor with coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|urinary_tract(1)	32						CCTTACCAGGTACCAGCCGAG	0.662													8	52					0	0	1	0	0	A	28822965	T	A	28822965	5	1	51	1	0	0	0	0	0	0	1	0	17306	1652	57	4	86	4	WAC	10	28822965	Splice_Site	SNP	T	TCGA-NF-A4WX-01A-11D-A28R-08		28822965	106711782	20	9099										
ZCCHC24	219654	broad.mit.edu	37	chr10	81146031	81146031	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	agggcgacacgcagcccctcGgagtagcacagggaagcagc	15	13	0	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr10:81146031G>A	ENST00000372333.3	-	4	667	c.617C>T	c.(616-618)cCg>cTg	p.P206L	RP11-342M3.5_ENST00000438554.2_RNA|ZCCHC24_ENST00000372336.3_3'UTR			Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	152							nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)	9						GCAGCCCCTCGGAGTAGCACA	0.697													7	6					0	0	1	0	0	A	81146031	G	A	81146031	3	1	51	1	0	0	0	0	1	0	0	0	17645	1131	39	1		1	ZCCHC24	10	81146031	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	52323066	81146031	54388716	21	9100										
OR5D14	219436	broad.mit.edu	37	chr11	55563682	55563682	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tgtacactactgatcatcctCacttcctatgttttcatttt	3	11	3	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr11:55563682C>T	ENST00000335605.1	+	1	651	c.651C>T	c.(649-651)ctC>ctT	p.L217L		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TGATCATCCTCACTTCCTATG	0.478													21	103					0	0	1	0	0	T	55563682	C	T	55563682	2	4	51	1	0	0	0	0	0	0	0	1	11201	813	29	3		3	OR5D14	11	55563682	Silent	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		55563682	79442834	22	9101										
CBL	867	broad.mit.edu	37	chr11	119077179	119077179	+	Frame_Shift_Del	DEL	G	G	-													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ccgggggcggcagcggctccGggggctcgggttcgggtggc							TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr11:119077179delG	ENST00000264033.4	+	1	428	c.52delG	c.(52-54)ggfs	p.G19fs		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	19					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CAGCGGCTCCGGGGGCTCGGG	0.736			"T, Mis S, O"	MLL	"AML, JMML, MDS"				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				2	4	---	---	---	---						-	119077179	G	-	119077179	7	5	51	1	0	1	0	1	0	0	0	0	2718	1116	39	0	54	0	CBL	11	119077179	Frame_Shift_Del	DEL	G	TCGA-NF-A4WX-01A-11D-A28R-08	63513497	119077179	15929337	23	9102										
C11orf63	79864	broad.mit.edu	37	chr11	122805248	122805248	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gaccagccaagctcaagattCgaaagcagtgtaaacaccag	9	11	1	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr11:122805248C>T	ENST00000227349.2	+	5	1396	c.1099C>T	c.(1099-1101)Cga>Tga	p.R367*	C11orf63_ENST00000531316.1_Nonsense_Mutation_p.R367*	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	367										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GCTCAAGATTCGAAAGCAGTG	0.468													9	28					0	0	1	0	0	T	122805248	C	T	122805248	4	4	51	1	0	0	0	0	0	1	0	0	1659	876	31	1	1177	1	C11orf63	11	122805248	Nonsense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	3728069	122805248	12201268	24	9103										
BRCA2	675	broad.mit.edu	37	chr13	32929088	32929088	+	Frame_Shift_Del	DEL	G	G	-													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tctcatttgtatgaacatctGactttggaaaaatcttcaag							TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr13:32929088delG	ENST00000544455.1	+	14	7325	c.7098delG	c.(7096-7098)ctfs	p.L2366fs	BRCA2_ENST00000380152.3_Frame_Shift_Del_p.L2366fs	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2366	Interaction with FANCD2.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATGAACATCTGACTTTGGAAA	0.358			"D, Mis, N, F, S"		"breast, ovarian, pancreatic"	"breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			46	49	---	---	---	---						-	32929088	G	-	32929088	7	5	51	1	0	1	0	1	0	0	0	0	1501	1277	45	0	7148	0	BRCA2	13	32929088	Frame_Shift_Del	DEL	G	TCGA-NF-A4WX-01A-11D-A28R-08		32929088	82240790	25	9104										
N4BP2L2	10443	broad.mit.edu	37	chr13	33018126	33018126	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gagatgggtcctgatctcccGgtgtaagatcacttaagaat	11	8	2	4			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr13:33018126G>T	ENST00000357505.6	-	7	607	c.503C>A	c.(502-504)cCg>cAg	p.P168Q	N4BP2L2_ENST00000504114.1_Missense_Mutation_p.P168Q|N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000399396.3_Missense_Mutation_p.P183Q|N4BP2L2_ENST00000446957.2_Intron	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	179										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		CTGATCTCCCGGTGTAAGATC	0.383													3	16					0.150653	0.150653	1	1	0	T	33018126	G	T	33018126	3	4	51	1	0	0	0	0	1	0	0	0	10159	1116	39	5	1722	5	N4BP2L2	13	33018126	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	89038	33018126	82151752	26	9105										
DHRS4L2	317749	broad.mit.edu	37	chr14	24464290	24464290	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cctagtctccaatgctgctgTcaaccctttctttggaagcc	7	14	3	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr14:24464290T>C	ENST00000335125.6	+	3	482	c.356T>C	c.(355-357)gTc>gCc	p.V119A	DHRS4L2_ENST00000382755.4_Missense_Mutation_p.V117A|DHRS4L2_ENST00000534993.1_Missense_Mutation_p.V18A|DHRS4L2_ENST00000545240.1_Missense_Mutation_p.V119A|DHRS4L2_ENST00000543805.1_Intron|DHRS4L2_ENST00000537912.1_Intron|DHRS4L2_ENST00000558753.1_Intron|DHRS4L2_ENST00000397071.1_Missense_Mutation_p.V119A	NM_198083.3	NP_932349.2	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4 like 2	74							binding|oxidoreductase activity			breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	10				GBM - Glioblastoma multiforme(265;0.00962)		AATGCTGCTGTCAACCCTTTC	0.537													82	375					0	0	1	0	0	C	24464290	T	C	24464290	3	2	51	1	0	0	0	0	1	0	0	0	4522	1667	58	4	366	4	DHRS4L2	14	24464290	Missense_Mutation	SNP	T	TCGA-NF-A4WX-01A-11D-A28R-08		24464290	82885250	27	9106										
FOXN3	1112	broad.mit.edu	37	chr14	89628877	89628877	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	ccctgccgcttctttcatctCctcatcatcgctctcggggg	8	17	6	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr14:89628877C>A	ENST00000345097.4	-	7	1470	c.1354G>T	c.(1354-1356)Gag>Tag	p.E452*	FOXN3_ENST00000261302.5_Nonsense_Mutation_p.E452*|FOXN3_ENST00000555353.1_Nonsense_Mutation_p.E430*|FOXN3_ENST00000557258.1_Nonsense_Mutation_p.E430*	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	452					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTTTCATCTCCTCATCATCG	0.567													16	36					1.99824e-07	2.14097e-07	1	1	0	A	89628877	C	A	89628877	4	1	51	1	0	0	0	0	0	1	0	0	6054	864	30	2	122	2	FOXN3	14	89628877	Nonsense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	65164587	89628877	17720663	28	9107										
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr17:7577120C>T	ENST00000420246.2	-	8	950	c.818G>A	c.(817-819)cGt>cAt	p.R273H	TP53_ENST00000359597.4_Missense_Mutation_p.R273H|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R273H|TP53_ENST00000455263.2_Missense_Mutation_p.R273H|TP53_ENST00000269305.4_Missense_Mutation_p.R273H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	2					0	0	1	0	0	T	7577120	C	T	7577120	3	4	51	1	0	0	0	0	1	0	0	0	16441	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		7577120	73618090	29	9108										
PLXDC1	57125	broad.mit.edu	37	chr17	37264406	37264406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gtaaacaactgtggagttgtCggagtagccagggttgaagt	15	5	0	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr17:37264406C>T	ENST00000315392.4	-	5	773	c.562G>A	c.(562-564)Gac>Aac	p.D188N	PLXDC1_ENST00000539608.1_Missense_Mutation_p.D115N|PLXDC1_ENST00000444911.2_Missense_Mutation_p.D148N|PLXDC1_ENST00000493200.1_5'UTR|PLXDC1_ENST00000394316.2_Missense_Mutation_p.D188N	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	188					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						GTGGAGTTGTCGGAGTAGCCA	0.522													17	161					0	0	1	0	0	T	37264406	C	T	37264406	3	4	51	1	0	0	0	0	1	0	0	0	12164	884	31	1	980	1	PLXDC1	17	37264406	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	29687286	37264406	43930804	30	9109										
LRRC46	90506	broad.mit.edu	37	chr17	45911901	45911901	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cagtctctatctgcaaggggTaacttctttctccacccttc	6	14	4	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr17:45911901T>C	ENST00000269025.4	+	3	588		c.e3+2			NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						CTGCAAGGGGTAACTTCTTTC	0.527													57	3					0	0	1	0	0	C	45911901	T	C	45911901	5	2	51	1	0	0	0	0	0	0	1	0	9047	1652	57	4	237	4	LRRC46	17	45911901	Splice_Site	SNP	T	TCGA-NF-A4WX-01A-11D-A28R-08	8647495	45911901	35283309	31	9110										
RNF43	54894	broad.mit.edu	37	chr17	56492928	56492928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cagccagctgcagctggtggCcaccactcatgctaccagct	10	16	1	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr17:56492928C>T	ENST00000584437.1	-	1	1966	c.11G>A	c.(10-12)gGc>gAc	p.G4D	RNF43_ENST00000583753.1_Missense_Mutation_p.G4D|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000581868.1_Intron|RNF43_ENST00000500597.2_Missense_Mutation_p.G4D|RNF43_ENST00000407977.2_Missense_Mutation_p.G4D|RNF43_ENST00000577716.1_Missense_Mutation_p.G4D			Q68DV7	RNF43_HUMAN	ring finger protein 43	4						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGCTGGTGGCCACCACTCAT	0.572													58	1					0	0	1	0	0	T	56492928	C	T	56492928	3	4	51	1	0	0	0	0	1	0	0	0	13546	739	26	3	2376	3	RNF43	17	56492928	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	10581027	56492928	24702282	32	9111										
SRP68	6730	broad.mit.edu	37	chr17	74046599	74046599	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	aggcgctccttagtttcttcGctttcagcctaaacaagggc	9	12	2	0	rs148814451	byFrequency	TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr17:74046599G>A	ENST00000307877.2	-	9	1148	c.987C>T	c.(985-987)agC>agT	p.S329S	SRP68_ENST00000539137.1_Silent_p.S291S|SRP68_ENST00000355113.5_Silent_p.S228S|SRP68_ENST00000602720.1_5'UTR|SRP68_ENST00000542536.2_5'UTR	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	329					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						TAGTTTCTTCGCTTTCAGCCT	0.517													81	0					0	0	1	0	0	A	74046599	G	A	74046599	2	1	51	1	0	0	0	0	0	0	0	1	15211	1078	38	1		1	SRP68	17	74046599	Silent	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	17553671	74046599	7148611	33	9112										
FOXK2	3607	broad.mit.edu	37	chr17	80545021	80545021	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cagacggcacagaccaccccGgtccagacggtgaccatagt	11	15	0	4	rs139592674		TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr17:80545021G>T	ENST00000335255.5	+	8	1833	c.1659G>T	c.(1657-1659)ccG>ccT	p.P553P		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	553					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			AGACCACCCCGGTCCAGACGG	0.532													10	103					3.07112e-06	3.17702e-06	1	1	0	T	80545021	G	T	80545021	2	4	51	1	0	0	0	0	0	0	0	1	6048	1103	39	5		5	FOXK2	17	80545021	Silent	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	6498422	80545021	650189	34	9113										
SH3GL1	6455	broad.mit.edu	37	chr19	4363847	4363847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tcttgtagtcaaagtccaggCggcggccctccagtttcttc	10	13	3	0			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr19:4363847C>T	ENST00000269886.3	-	6	672	c.494G>A	c.(493-495)cGc>cAc	p.R165H	AC007292.6_ENST00000594444.1_RNA|SH3GL1_ENST00000598564.1_Missense_Mutation_p.R101H|SH3GL1_ENST00000417295.2_Missense_Mutation_p.R117H	NM_003025.3	NP_003016.1	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	165	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			NS(1)|endometrium(2)|kidney(16)|large_intestine(3)|lung(2)|ovary(2)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		AAAGTCCAGGCGGCGGCCCTC	0.622			T	MLL	AL								36	2					0	0	1	0	0	T	4363847	C	T	4363847	3	4	51	1	0	0	0	0	1	0	0	0	14304	768	27	1	632	1	SH3GL1	19	4363847	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		4363847	54765136	35	9114										
PLIN3	10226	broad.mit.edu	37	chr19	4859938	4859938	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gcgtcgcagacagtcttgatGtgcgggtagctctccttggt	14	10	2	2			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr19:4859938G>A	ENST00000221957.4	-	3	341	c.165C>T	c.(163-165)caC>caT	p.H55H	PLIN3_ENST00000592528.1_Silent_p.H55H|PLIN3_ENST00000585479.1_Silent_p.H55H	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	55					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	CAGTCTTGATGTGCGGGTAGC	0.637													8	16					0	0	1	0	0	A	4859938	G	A	4859938	2	1	51	1	0	0	0	0	0	0	0	1	12138	1368	48	3		3	PLIN3	19	4859938	Silent	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	496091	4859938	54269045	36	9115										
NWD1	284434	broad.mit.edu	37	chr19	16860396	16860396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tcattcagaccttctgcggaCgccaggaactcctggcccgg	11	15	3	1	rs148848880		TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr19:16860396C>T	ENST00000524140.2	+	6	1361	c.943C>T	c.(943-945)Cgc>Tgc	p.R315C	NWD1_ENST00000552788.1_Missense_Mutation_p.R315C|NWD1_ENST00000549814.1_Missense_Mutation_p.R315C|NWD1_ENST00000379808.3_Missense_Mutation_p.R315C|NWD1_ENST00000523826.1_Missense_Mutation_p.R109C|NWD1_ENST00000339803.6_Missense_Mutation_p.R180C	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	315							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTTCTGCGGACGCCAGGAACT	0.627													14	35					0	0	1	0	0	T	16860396	C	T	16860396	3	4	51	1	0	0	0	0	1	0	0	0	10828	536	19	1	544	1	NWD1	19	16860396	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08	12000458	16860396	42268587	37	9116										
WDR62	284403	broad.mit.edu	37	chr19	36591677	36591677	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gtccccaggaagctggccgcGggcacccctccttcctgccc	11	20	0	0	rs141094124		TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr19:36591677G>A	ENST00000401500.2	+	23	2802	c.2767G>A	c.(2767-2769)Ggg>Agg	p.G923R	WDR62_ENST00000270301.7_Missense_Mutation_p.G923R	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	923					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGCTGGCCGCGGGCACCCCTC	0.607													18	87					0	0	1	0	0	A	36591677	G	A	36591677	3	1	51	1	0	0	0	0	1	0	0	0	17372	1116	39	1	2857	1	WDR62	19	36591677	Missense_Mutation	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	19731281	36591677	22537306	38	9117										
BAGE2	85319	broad.mit.edu	37	chr21	11071749	11071750	+	RNA	INS	-	-	ACTT													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	caaagcactgctcagtgataINSacttaaccacccctccatcc					rs141387552		TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr21:11071749_11071750insACTT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gctcagtgataacttaaccacc	0.485													3	4	---	---	---	---						ACTT	11071750	-	ACTT	11071749	6	5	51	0	1	1	1	0	0	0	0	0	1290	377	13	0		0	BAGE2	21	11071749	RNA	INS	-	TCGA-NF-A4WX-01A-11D-A28R-08		11071749	37058146	39	9118										
BAGE2	85319	broad.mit.edu	37	chr21	11079693	11079693	+	RNA	DEL	T	T	-													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	tgaaacttttttcaatgcccTttttttaatttttttttaaa							TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr21:11079693delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCAATGCCCtttttttaatt	0.393													2	4	---	---	---	---						-	11079693	T	-	11079693	6	5	51	0	1	1	0	1	0	0	0	0	1290	1624	56	0		0	BAGE2	21	11079693	RNA	DEL	T	TCGA-NF-A4WX-01A-11D-A28R-08	7944	11079693	37050202	40	9119										
BAGE2	85319	broad.mit.edu	37	chr21	11092870	11092871	+	RNA	INS	-	-	T													0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	catatacatacataaatttaINSaatgctggattcctcaccag					rs58400598		TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr21:11092870_11092871insT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACATAAATTTAAATGCTGGATT	0.376													3	5	---	---	---	---						T	11092871	-	T	11092870	6	5	51	0	1	1	1	0	0	0	0	0	1290	377	13	0		0	BAGE2	21	11092870	RNA	INS	-	TCGA-NF-A4WX-01A-11D-A28R-08	13177	11092870	37037025	41	9120										
KLHL22	84861	broad.mit.edu	37	chr22	20825725	20825725	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	atatgaaatgtaggatttggCacatagcattgtaggacaca	10	5	0	1			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr22:20825725C>T	ENST00000328879.4	-	3	461	c.305G>A	c.(304-306)tGc>tAc	p.C102Y	KLHL22_ENST00000440659.2_Intron	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	102	BTB.				cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TAGGATTTGGCACATAGCATT	0.502													15	85					0	0	1	0	0	T	20825725	C	T	20825725	3	4	51	1	0	0	0	0	1	0	0	0	8419	710	25	3	1619	3	KLHL22	22	20825725	Missense_Mutation	SNP	C	TCGA-NF-A4WX-01A-11D-A28R-08		20825725	30478841	42	9121										
NCAPH2	29781	broad.mit.edu	37	chr22	50955912	50955912	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	gatttcatctctggaaagagGtgagttctgcagccactcac	10	10	4	2			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chr22:50955912G>A	ENST00000395701.3	+	3	360		c.e3+1		NCAPH2_ENST00000395698.3_Splice_Site|NCAPH2_ENST00000420993.2_Splice_Site|NCAPH2_ENST00000299821.11_Splice_Site			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2						chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CTGGAAAGAGGTGAGTTCTGC	0.607													102	75					0	0	1	0	0	A	50955912	G	A	50955912	5	1	51	1	0	0	0	0	0	0	1	0	10256	1275	44	3	277	3	NCAPH2	22	50955912	Splice_Site	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08	30130187	50955912	348654	43	9122										
PLAC1	10761	broad.mit.edu	37	chrX	133700506	133700506	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0454545454545455	2	1	0.616938616938617	0	0.668350168350168	0.333333333333333	1	0	cggtaggtgaactggtaggcGtgtggctgaacatggtttgg	18	5	0	2			TCGA-NF-A4WX-01A-11D-A28R-08	TCGA-NF-A4WX-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	09a88841-5d21-4363-bc57-503b9c2be4d2	86a042ba-233d-45e8-9fd6-fcaba878cfb8	g.chrX:133700506G>A	ENST00000359237.4	-	3	492	c.207C>T	c.(205-207)caC>caT	p.H69H	PLAC1_ENST00000476971.1_5'UTR	NM_021796.3	NP_068568.1	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1	69					placenta development	extracellular region				large_intestine(4)|lung(1)|pancreas(1)	6	Acute lymphoblastic leukemia(192;0.000127)					ACTGGTAGGCGTGTGGCTGAA	0.498													61	4					0	0	1	0	0	A	133700506	G	A	133700506	2	1	51	1	0	0	0	0	0	0	0	1	12059	1136	40	1		1	PLAC1	23	133700506	Silent	SNP	G	TCGA-NF-A4WX-01A-11D-A28R-08		133700506	21570054	44	9123										
PEX14	5195	broad.mit.edu	37	chr1	10689685	10689685	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gccctgcggccgtgaaccacCacagcagcagcgacatctca	10	17	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:10689685C>A	ENST00000356607.4	+	9	855	c.775C>A	c.(775-777)Cac>Aac	p.H259N	PEX14_ENST00000538836.1_Missense_Mutation_p.H195N	NM_004565.2	NP_004556.1	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	259					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		CGTGAACCACCACAGCAGCAG	0.642													55	45					2.29192e-23	2.88011e-23	1	1	0	A	10689685	C	A	10689685	3	1	52	1	0	0	0	0	1	0	0	0	11789	594	21	5	809	5	PEX14	1	10689685	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		10689685	238560936	1	9124										
ARID1A	8289	broad.mit.edu	37	chr1	27106730	27106730	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ccccaatgccgtcctttcccCgcagagactggtcttggaaa	9	15	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:27106730C>A	ENST00000324856.7	+	20	6712	c.6341C>A	c.(6340-6342)cCg>cAg	p.P2114Q	ARID1A_ENST00000540690.1_Missense_Mutation_p.P442Q|ARID1A_ENST00000374152.2_Missense_Mutation_p.P1731Q|ARID1A_ENST00000457599.2_Missense_Mutation_p.P1897Q	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2114					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTCCTTTCCCCGCAGAGACTG	0.597			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								60	137					7.47603e-22	9.23127e-22	1	1	0	A	27106730	C	A	27106730	3	1	52	1	0	0	0	0	1	0	0	0	910	652	23	5	6419	5	ARID1A	1	27106730	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	16417045	27106730	222143891	2	9125										
RLF	6018	broad.mit.edu	37	chr1	40703957	40703957	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggattcattataaaaataaaCatcaaattggcagtgacaga	7	5	2	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:40703957C>T	ENST00000372771.4	+	8	3610	c.3583C>T	c.(3583-3585)Cat>Tat	p.H1195Y		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1195					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TAAAAATAAACATCAAATTGG	0.358													31	32					0	0	1	0	0	T	40703957	C	T	40703957	3	4	52	1	0	0	0	0	1	0	0	0	13440	478	17	3	3613	3	RLF	1	40703957	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	13597227	40703957	208546664	3	9126										
RAD54L	8438	broad.mit.edu	37	chr1	46725698	46725698	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tccgccgggccctccatgacCccctggaaaaagatgccttg	10	16	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:46725698C>T	ENST00000371975.4	+	5	1008	c.334C>T	c.(334-336)Ccc>Tcc	p.P112S	RAD54L_ENST00000442598.1_Missense_Mutation_p.P112S	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	112					meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		CCTCCATGACCCCCTGGAAAA	0.537								Direct reversal of damage;Homologous recombination					93	84					0	0	1	0	0	T	46725698	C	T	46725698	3	4	52	1	0	0	0	0	1	0	0	0	13044	623	22	3	352	3	RAD54L	1	46725698	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	6021741	46725698	202524923	4	9127										
TTC22	55001	broad.mit.edu	37	chr1	55251777	55251777	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agtagaagatttttgccaggCgattcaggatgggaggttgg	16	4	1	2	rs145786276		TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:55251777C>T	ENST00000371276.4	-	5	1002	c.899G>A	c.(898-900)cGc>cAc	p.R300H	TTC22_ENST00000371274.4_Missense_Mutation_p.R300H	NM_001114108.1	NP_001107580.1	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22	300							binding			kidney(1)|large_intestine(1)|lung(7)|skin(1)	10						TTTTGCCAGGCGATTCAGGAT	0.502													19	25					0	0	1	0	0	T	55251777	C	T	55251777	3	4	52	1	0	0	0	0	1	0	0	0	16750	768	27	1	925	1	TTC22	1	55251777	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	8526079	55251777	193998844	5	9128										
SPTA1	6708	broad.mit.edu	37	chr1	158581178	158581178	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acacttgctctggggtaaggGcctgaaaagtataaaaagag	12	6	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:158581178G>T	ENST00000368148.3	-	52	7316	c.7134_splice	c.e52-1	p.A2379_splice	SPTA1_ENST00000368147.3_Splice_Site_p.A2376_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2379	EF-hand 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGGGGTAAGGGCCTGAAAAGT	0.458													11	94					5.50884e-06	5.97141e-06	1	1	0	T	158581178	G	T	158581178	5	4	52	1	0	0	0	0	0	0	1	0	15171	1217	42	5	127	5	SPTA1	1	158581178	Splice_Site	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	103329401	158581178	90669443	6	9129										
OR10J5	127385	broad.mit.edu	37	chr1	159505081	159505081	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acagtgaggtgggagacacaGgtggcaaaggtcttcttccg	15	8	2	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:159505081G>A	ENST00000334857.2	-	1	761	c.717C>T	c.(715-717)acC>acT	p.T239T		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					GGGAGACACAGGTGGCAAAGG	0.478													6	130					0	0	1	0	0	A	159505081	G	A	159505081	2	1	52	1	0	0	0	0	0	0	0	1	10959	987	35	3		3	OR10J5	1	159505081	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	923903	159505081	89745540	7	9130										
C1orf110	339512	broad.mit.edu	37	chr1	162825078	162825078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcttcatggggtctttgaggCcagcatcatgtgaaggaggc	14	8	4	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:162825078C>T	ENST00000367912.1	-	4	557	c.383G>A	c.(382-384)gGc>gAc	p.G128D	C1orf110_ENST00000367911.2_Missense_Mutation_p.G124D|C1orf110_ENST00000367910.1_Missense_Mutation_p.G129D|C1orf110_ENST00000524691.1_Intron			Q86UF4	CA110_HUMAN	chromosome 1 open reading frame 110	129										endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	12						GTCTTTGAGGCCAGCATCATG	0.463													175	296					0	0	1	0	0	T	162825078	C	T	162825078	3	4	52	1	0	0	0	0	1	0	0	0	1996	739	26	3	526	3	C1orf110	1	162825078	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	3319997	162825078	86425543	8	9131										
ILDR2	387597	broad.mit.edu	37	chr1	166896409	166896409	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtcagcctggatccggtaacCtttgcgaactgttgagaaaa	11	9	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:166896409C>G	ENST00000271417.3	-	7	944	c.889G>C	c.(889-891)Ggt>Cgt	p.G297R	ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000526687.1_Missense_Mutation_p.G189R|ILDR2_ENST00000469934.2_Missense_Mutation_p.G297R|ILDR2_ENST00000529071.1_Missense_Mutation_p.G278R|ILDR2_ENST00000528703.1_Missense_Mutation_p.G238R|ILDR2_ENST00000525740.1_Missense_Mutation_p.G170R	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	297						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						ATCCGGTAACCTTTGCGAACT	0.448													5	177					0	0	1	0	0	G	166896409	C	G	166896409	3	3	52	1	0	0	0	0	1	0	0	0	7753	681	24	5	1046	5	ILDR2	1	166896409	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	4071331	166896409	82354212	9	9132										
PIGC	5279	broad.mit.edu	37	chr1	172411608	172411608	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcaccacactggactcaaatAccacagcccaatattggtat	5	13	2	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:172411608A>T	ENST00000367728.1	-	1	1618	c.155T>A	c.(154-156)gTa>gAa	p.V52E	C1orf105_ENST00000367727.4_Intron|PIGC_ENST00000258324.1_Missense_Mutation_p.V52E|PIGC_ENST00000344529.4_Missense_Mutation_p.V52E|PIGC_ENST00000484368.1_Intron			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	52					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						GGACTCAAATACCACAGCCCA	0.493													53	273					0	0	1	0	0	T	172411608	A	T	172411608	3	4	52	1	0	0	0	0	1	0	0	0	11933	391	14	4	742	4	PIGC	1	172411608	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08	5515199	172411608	76839013	10	9133										
CD55	1604	broad.mit.edu	37	chr1	207499029	207499029	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttgatgtaccaggtggcataTtatttggtgcaaccatctcc	9	9	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:207499029T>C	ENST00000367064.3	+	4	799	c.541T>C	c.(541-543)Tta>Cta	p.L181L	CD55_ENST00000367067.4_3'UTR|CD55_ENST00000314754.8_Silent_p.L181L|CD55_ENST00000391921.4_Silent_p.L117L|CD55_ENST00000465534.1_3'UTR|CD55_ENST00000391920.4_Silent_p.L181L|CD55_ENST00000367062.4_Silent_p.L181L|CD55_ENST00000367065.5_Silent_p.L181L|CD55_ENST00000367063.2_Silent_p.L181L	NM_000574.3	NP_000565.1	P08174	DAF_HUMAN	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	181	Sushi 3.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16					Chloramphenicol(DB00446)	AGGTGGCATATTATTTGGTGC	0.343													18	53					0	0	1	0	0	C	207499029	T	C	207499029	2	2	52	1	0	0	0	0	0	0	0	1	3046	1490	52	4		4	CD55	1	207499029	Silent	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	35087421	207499029	41751592	11	9134										
NSL1	25936	broad.mit.edu	37	chr1	212964986	212964986	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtcacagcccgcttcgaggtGcagcgcacccgaaagtcttc	11	15	2	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:212964986G>T	ENST00000366977.3	-	1	138	c.120C>A	c.(118-120)tgC>tgA	p.C40*	NSL1_ENST00000366975.6_Nonsense_Mutation_p.C40*|NSL1_ENST00000366976.1_Nonsense_Mutation_p.C40*|NSL1_ENST00000422588.2_Nonsense_Mutation_p.C40*	NM_015471.3	NP_056286.3	Q96IY1	NSL1_HUMAN	NSL1, MIS12 kinetochore complex component	40					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		GCTTCGAGGTGCAGCGCACCC	0.647													21	154					3.51602e-12	4.05914e-12	1	1	0	T	212964986	G	T	212964986	4	4	52	1	0	0	0	0	0	1	0	0	10720	1311	46	5	838	5	NSL1	1	212964986	Nonsense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	5465957	212964986	36285635	12	9135										
DISC1	27185	broad.mit.edu	37	chr1	231954196	231954196	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agttccaggaatgtcaaaaaGctgggaagtgttaaagaaga	12	4	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:231954196G>C	ENST00000439617.2	+	9	1967	c.1914G>C	c.(1912-1914)aaG>aaC	p.K638N	DISC1_ENST00000539444.1_3'UTR|TRAX_ENST00000602962.1_3'UTR|DISC1_ENST00000602281.1_Missense_Mutation_p.K638N|DISC1_ENST00000366633.3_Missense_Mutation_p.K638N|DISC1_ENST00000366637.3_5'UTR|DISC1_ENST00000537876.1_Intron|DISC1_ENST00000535983.1_Missense_Mutation_p.K638N|DISC1_ENST00000602873.1_3'UTR|DISC1_ENST00000366636.4_Missense_Mutation_p.K638N	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	638	Interaction with ATF4 and ATF5.|Interaction with TRAF3IP1.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				ATGTCAAAAAGCTGGGAAGTG	0.478													34	136					0	0	1	0	0	C	231954196	G	C	231954196	3	2	52	1	0	0	0	0	1	0	0	0	4566	962	34	5	2321	5	DISC1	1	231954196	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	18989210	231954196	17296425	13	9136										
LYST	1130	broad.mit.edu	37	chr1	235955054	235955055	+	Frame_Shift_Ins	INS	-	-	TTTT													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	atttgtttcttttctttatcINSttctttcctttttctgtagt							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:235955054_235955055insTTTT	ENST00000389794.3	-	12	4661_4662	c.4487_4488insAAAA	c.(4486-4488)aatfs	p.N1496fs	LYST_ENST00000389793.2_Frame_Shift_Ins_p.N1496fs|LYST_ENST00000536965.1_Intron			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1496					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTTCTTTATCTTCTTTCCTTT	0.361													80	53	---	---	---	---						TTTT	235955055	-	TTTT	235955054	7	5	52	1	0	1	1	0	0	0	0	0	9173	912	32	0	7085	0	LYST	1	235955054	Frame_Shift_Ins	INS	-	TCGA-NF-A4X2-01A-11D-A28R-08	4000858	235955054	13295567	14	9137										
OR2T1	26696	broad.mit.edu	37	chr1	248569431	248569431	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggaagatattaccttatatcGgcacaactgtaggatcaatg	9	7	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr1:248569431G>A	ENST00000366474.1	+	1	136	c.136G>A	c.(136-138)Ggc>Agc	p.G46S		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTTATATCGGCACAACTGT	0.383													28	77					0	0	1	0	0	A	248569431	G	A	248569431	3	1	52	1	0	0	0	0	1	0	0	0	11063	1116	39	1	138	1	OR2T1	1	248569431	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	12614377	248569431	681190	15	9138										
NRXN1	9378	broad.mit.edu	37	chr2	50765622	50765622	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gatgcagcccacgtagccatAgttgagcagagcagtccaca	11	12	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:50765622A>C	ENST00000404971.1	-	11	3371	c.2032T>G	c.(2032-2034)Tat>Gat	p.Y678D	NRXN1_ENST00000402717.3_Missense_Mutation_p.Y630D|NRXN1_ENST00000401669.2_Missense_Mutation_p.Y638D|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406859.3_Missense_Mutation_p.Y638D|NRXN1_ENST00000405472.3_Missense_Mutation_p.Y630D|NRXN1_ENST00000406316.2_Missense_Mutation_p.Y638D	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	638	EGF-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACGTAGCCATAGTTGAGCAGA	0.517													79	154					0	0	1	0	0	C	50765622	A	C	50765622	3	2	52	1	0	0	0	0	1	0	0	0	10712	420	15	4	2930	4	NRXN1	2	50765622	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08		50765622	192433751	16	9139										
ZNF638	27332	broad.mit.edu	37	chr2	71653747	71653747	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acttaacttaaagaagaaaaAggggaaaacttccactcctc	6	9	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:71653747A>T	ENST00000409544.1	+	24	5378	c.4748A>T	c.(4747-4749)aAg>aTg	p.K1583M	ZNF638_ENST00000264447.4_Missense_Mutation_p.K1583M|ZNF638_ENST00000355812.3_3'UTR|ZNF638_ENST00000409407.1_Missense_Mutation_p.K523M	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1583	Poly-Lys.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AAGAAGAAAAAGGGGAAAACT	0.418													10	44					0	0	1	0	0	T	71653747	A	T	71653747	3	4	52	1	0	0	0	0	1	0	0	0	18111	72	3	4	4838	4	ZNF638	2	71653747	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08	20888125	71653747	171545626	17	9140										
SLC5A7	60482	broad.mit.edu	37	chr2	108627055	108627055	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	attcttaaccaacatttgcaTctcctatctagccaagtatc	3	12	3	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:108627055T>G	ENST00000264047.2	+	9	1757	c.1481T>G	c.(1480-1482)aTc>aGc	p.I494S	SLC5A7_ENST00000540517.1_Missense_Mutation_p.I389S|SLC5A7_ENST00000409059.1_Missense_Mutation_p.I494S	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	494					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	AACATTTGCATCTCCTATCTA	0.353													8	22					0	0	1	0	0	G	108627055	T	G	108627055	3	3	52	1	0	0	0	0	1	0	0	0	14724	1435	50	4	1511	4	SLC5A7	2	108627055	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	36973308	108627055	134572318	18	9141										
RIF1	55183	broad.mit.edu	37	chr2	152331526	152331526	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aactaagttgtatggcaaacTctgtaataaaaaatctacag	6	6	2	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:152331526T>G	ENST00000243326.4	+	35	7843	c.7360T>G	c.(7360-7362)Tct>Gct	p.S2454A	RIF1_ENST00000428287.2_Missense_Mutation_p.S2428A|RIF1_ENST00000453091.2_Missense_Mutation_p.S2428A|RIF1_ENST00000444746.2_Missense_Mutation_p.S2454A|RIF1_ENST00000430328.2_Missense_Mutation_p.S2428A			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	2454	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TATGGCAAACTCTGTAATAAA	0.343													4	25					0	0	1	0	0	G	152331526	T	G	152331526	3	3	52	1	0	0	0	0	1	0	0	0	13408	1551	54	4	7498	4	RIF1	2	152331526	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	43704471	152331526	90867847	19	9142										
CYTIP	9595	broad.mit.edu	37	chr2	158272436	158272436	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agcactcatcatctgtactcGtctgccgactgaaggcaccc	8	15	4	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:158272436G>A	ENST00000264192.3	-	8	954	c.833C>T	c.(832-834)aCg>aTg	p.T278M	CYTIP_ENST00000540637.1_Missense_Mutation_p.T172M	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	278	Ser-rich.			T -> Q (in Ref. 5; AAA16575).	regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						ATCTGTACTCGTCTGCCGACT	0.542													13	48					0	0	1	0	0	A	158272436	G	A	158272436	3	1	52	1	0	0	0	0	1	0	0	0	4230	1145	40	1	250	1	CYTIP	2	158272436	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	5940910	158272436	84926937	20	9143										
KCNH7	90134	broad.mit.edu	37	chr2	163302838	163302838	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cagtgtatatgaccaacagcAggataagccagtcccagact	9	11	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:163302838A>T	ENST00000332142.5	-	7	1343	c.1244T>A	c.(1243-1245)cTg>cAg	p.L415Q	KCNH7_ENST00000328032.4_Missense_Mutation_p.L408Q	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	415					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	GACCAACAGCAGGATAAGCCA	0.453													5	25					0	0	1	0	0	T	163302838	A	T	163302838	3	4	52	1	0	0	0	0	1	0	0	0	8080	188	7	4	2452	4	KCNH7	2	163302838	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08	5030402	163302838	79896535	21	9144										
PGAP1	80055	broad.mit.edu	37	chr2	197707534	197707534	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggtttacatggatcaggattAagtttaaaataatacctata	7	4	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr2:197707534A>C	ENST00000354764.3	-	26	2655	c.2541T>G	c.(2539-2541)ctT>ctG	p.L847L		NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1	847					attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						GATCAGGATTAAGTTTAAAAT	0.279													34	18					0	0	1	0	0	C	197707534	A	C	197707534	2	2	52	1	0	0	0	0	0	0	0	1	11824	349	13	4		4	PGAP1	2	197707534	Silent	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08	34404696	197707534	45491839	22	9145										
SGOL1	151648	broad.mit.edu	37	chr3	20216367	20216367	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ctctttcgaattcaaaagacTtccctgccaaatgactggtt	6	11	2	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:20216367T>A	ENST00000412997.1	-	6	1007	c.656A>T	c.(655-657)aAg>aTg	p.K219M	SGOL1_ENST00000421451.1_Missense_Mutation_p.K219M|SGOL1_ENST00000417364.1_Intron|SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000425061.1_Intron|SGOL1_ENST00000306698.2_Intron|SGOL1_ENST00000443724.1_Intron|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000419233.2_Intron|SGOL1_ENST00000442720.1_Intron|SGOL1_ENST00000429446.3_Intron|SGOL1_ENST00000383774.1_Intron|SGOL1_ENST00000263753.4_Missense_Mutation_p.K219M|SGOL1_ENST00000412868.1_Missense_Mutation_p.K219M|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1_ENST00000437051.1_Intron	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	219					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						TTCAAAAGACTTCCCTGCCAA	0.373													5	79					0	0	1	0	0	A	20216367	T	A	20216367	3	1	52	1	0	0	0	0	1	0	0	0	14269	1609	56	4	1065	4	SGOL1	3	20216367	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08		20216367	177806063	23	9146										
SUSD5	26032	broad.mit.edu	37	chr3	33216515	33216515	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cccccatttccaagccggtgCggccctgcaggatggtgtgt	13	14	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:33216515C>G	ENST00000309558.3	-	4	878	c.461G>C	c.(460-462)cGc>cCc	p.R154P		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	154	Sushi.				cell adhesion	integral to membrane	hyaluronic acid binding	p.R154H(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAAGCCGGTGCGGCCCTGCAG	0.567													40	70					0	0	1	0	0	G	33216515	C	G	33216515	3	3	52	1	0	0	0	0	1	0	0	0	15466	768	27	5	1436	5	SUSD5	3	33216515	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	13000148	33216515	164805915	24	9147										
CCR3	1232	broad.mit.edu	37	chr3	46306665	46306665	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtgaaatgacaacctcactaGatacagttgagacctttggt	9	8	1	4			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:46306665G>C	ENST00000357422.2	+	4	559	c.16G>C	c.(16-18)Gat>Cat	p.D6H	CCR3_ENST00000395940.2_Missense_Mutation_p.D6H|CCR3_ENST00000541018.1_Missense_Mutation_p.D6H|CCR3_ENST00000395942.2_Missense_Mutation_p.D6H|CCR3_ENST00000545097.1_Missense_Mutation_p.D27H			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	6					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		AACCTCACTAGATACAGTTGA	0.438													8	47					0	0	1	0	0	C	46306665	G	C	46306665	3	2	52	1	0	0	0	0	1	0	0	0	2964	942	33	2	85	2	CCR3	3	46306665	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	13090150	46306665	151715765	25	9148										
PLXNA1	5361	broad.mit.edu	37	chr3	126733148	126733148	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cctgcgacaccactgcgctgCcgacacacctgcatcgtgga	10	17	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:126733148C>A	ENST00000251772.4	+	11	2534	c.2465C>A	c.(2464-2466)gCc>gAc	p.A822D	PLXNA1_ENST00000393409.2_Missense_Mutation_p.A845D			Q9UIW2	PLXA1_HUMAN	plexin A1	845					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CACTGCGCTGCCGACACACCT	0.711													4	25					0.150653	0.151722	1	1	0	A	126733148	C	A	126733148	3	1	52	1	0	0	0	0	1	0	0	0	12166	739	26	5	2576	5	PLXNA1	3	126733148	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	80426483	126733148	71289282	26	9149										
DNAJC13	23317	broad.mit.edu	37	chr3	132202305	132202305	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggatggcgaccacttcagtcCataccccagcttaagtggtg	11	12	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:132202305C>G	ENST00000260818.6	+	28	3314	c.3066C>G	c.(3064-3066)tcC>tcG	p.S1022S		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1022							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						CACTTCAGTCCATACCCCAGC	0.458													11	84					0	0	1	0	0	G	132202305	C	G	132202305	2	3	52	1	0	0	0	0	0	0	0	1	4659	581	21	5		5	DNAJC13	3	132202305	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	5469157	132202305	65820125	27	9150										
ARMC8	25852	broad.mit.edu	37	chr3	137942260	137942260	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cttgcttcagcaagaaacctCaagcacagagctgaaaactg	8	11	2	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:137942260C>T	ENST00000469044.1	+	4	495	c.224C>T	c.(223-225)tCa>tTa	p.S75L	ARMC8_ENST00000538260.1_Missense_Mutation_p.S75L|ARMC8_ENST00000461822.1_Missense_Mutation_p.S75L|ARMC8_ENST00000358441.2_Missense_Mutation_p.S61L|ARMC8_ENST00000485396.1_Missense_Mutation_p.S33L|ARMC8_ENST00000489213.1_Missense_Mutation_p.S33L|ARMC8_ENST00000471453.1_Missense_Mutation_p.S61L|ARMC8_ENST00000393058.3_Missense_Mutation_p.S65L|ARMC8_ENST00000481646.1_Missense_Mutation_p.S61L|ARMC8_ENST00000470821.1_Missense_Mutation_p.S75L|ARMC8_ENST00000491704.1_Missense_Mutation_p.S33L	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	75							binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						CAAGAAACCTCAAGCACAGAG	0.383													37	11					0	0	1	0	0	T	137942260	C	T	137942260	3	4	52	1	0	0	0	0	1	0	0	0	956	838	29	3	196	3	ARMC8	3	137942260	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	5739955	137942260	60080170	28	9151										
CHST2	9435	broad.mit.edu	37	chr3	142840559	142840559	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agtgccgcaagtaccgcacaCtagtcataaagggtgtgcgc	12	11	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr3:142840559C>T	ENST00000309575.3	+	2	2285	c.901C>T	c.(901-903)Cta>Tta	p.L301L		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	301					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GTACCGCACACTAGTCATAAA	0.647													4	17					0	0	1	0	0	T	142840559	C	T	142840559	2	4	52	1	0	0	0	0	0	0	0	1	3426	564	20	3		3	CHST2	3	142840559	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	4898299	142840559	55181871	29	9152										
SLC10A6	345274	broad.mit.edu	37	chr4	87769940	87769941	+	Frame_Shift_Ins	INS	-	-	T													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggtgaaaatgttagagatggINStgccccccgggcagcagccc							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr4:87769940_87769941insT	ENST00000273905.6	-	1	475_476	c.328_329insA	c.(328-330)catfs	p.H110fs	SLC10A6_ENST00000505535.1_5'UTR	NM_197965.2	NP_932069.1	Q3KNW5	SOAT_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 6	110						integral to membrane|plasma membrane	bile acid:sodium symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	9		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		GTTAGAGATGGTGCCCCCCGGG	0.515													61	33	---	---	---	---						T	87769941	-	T	87769940	7	5	52	1	0	1	1	0	0	0	0	0	14432	1261	44	0	828	0	SLC10A6	4	87769940	Frame_Shift_Ins	INS	-	TCGA-NF-A4X2-01A-11D-A28R-08		87769940	103384336	30	9153										
NR3C2	0	broad.mit.edu	37	chr4	149356602	149356602	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cacaggtggtcctaaaattcCtgatagggaataatagtctt	9	7	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr4:149356602C>A	ENST00000355292.3	-	2	1773	c.1411G>T	c.(1411-1413)Gga>Tga	p.G471*	NR3C2_ENST00000511528.1_Nonsense_Mutation_p.G471*|NR3C2_ENST00000344721.4_Nonsense_Mutation_p.G471*|NR3C2_ENST00000342437.4_Nonsense_Mutation_p.G471*|NR3C2_ENST00000512865.1_Nonsense_Mutation_p.G471*|NR3C2_ENST00000358102.3_Nonsense_Mutation_p.G471*			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	471	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	CCTAAAATTCCTGATAGGGAA	0.433													23	48					3.62473e-10	4.05285e-10	1	1	0	A	149356602	C	A	149356602	4	1	52	1	0	0	0	0	0	1	0	0	10678	690	24	5	1575	5	NR3C2	4	149356602	Nonsense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	61586662	149356602	41797674	31	9154										
GLRA3	8001	broad.mit.edu	37	chr4	175649822	175649822	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gcggggatcattccatttctGacgaagaaagatattcactc	9	9	3	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr4:175649822G>C	ENST00000274093.3	-	4	797	c.295C>G	c.(295-297)Cag>Gag	p.Q99E	GLRA3_ENST00000436738.1_5'UTR|GLRA3_ENST00000340217.5_Missense_Mutation_p.Q99E	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	99					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	TTCCATTTCTGACGAAGAAAG	0.378													24	68					0	0	1	0	0	C	175649822	G	C	175649822	3	2	52	1	0	0	0	0	1	0	0	0	6497	1299	45	2	1127	2	GLRA3	4	175649822	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	26293220	175649822	15504454	32	9155										
MAN2A1	4124	broad.mit.edu	37	chr5	109117242	109117242	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tgatcattactggagtggctAttttacatccagaccctttt	7	9	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr5:109117242A>G	ENST00000261483.4	+	9	2572	c.1520A>G	c.(1519-1521)tAt>tGt	p.Y507C		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	507					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TGGAGTGGCTATTTTACATCC	0.373													14	25					0	0	1	0	0	G	109117242	A	G	109117242	3	3	52	1	0	0	0	0	1	0	0	0	9263	449	16	4	1554	4	MAN2A1	5	109117242	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08		109117242	71798018	33	9156										
FCHSD1	89848	broad.mit.edu	37	chr5	141023864	141023864	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gggaggggaagaccccaacaCggcccccaaattctcccctc	10	17	1	1	rs140791780	by1000genomes	TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr5:141023864C>T	ENST00000435817.2	-	17	1834	c.1784G>A	c.(1783-1785)cGt>cAt	p.R595H	FCHSD1_ENST00000523856.1_5'UTR|FCHSD1_ENST00000522783.1_Missense_Mutation_p.R521H|FCHSD1_ENST00000522126.1_3'UTR	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	595	SH3 2.								FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCCCAACACGGCCCCCAAA	0.632													3	14					0	0	1	0	0	T	141023864	C	T	141023864	3	4	52	1	0	0	0	0	1	0	0	0	5821	536	19	1	304	1	FCHSD1	5	141023864	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	31906622	141023864	39891396	34	9157										
SLC44A4	80736	broad.mit.edu	37	chr6	31833747	31833747	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggcaaaggctccagcgaggaCgcattggcccagggccagta	15	12	0	0	rs149591801		TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:31833747C>T	ENST00000544672.1	-	14	1458	c.1162G>A	c.(1162-1164)Gtc>Atc	p.V388I	SLC44A4_ENST00000375562.4_Missense_Mutation_p.V422I|SLC44A4_ENST00000229729.6_Missense_Mutation_p.V464I	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	464						integral to membrane|plasma membrane	choline transmembrane transporter activity	p.V464I(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	CCAGCGAGGACGCATTGGCCC	0.557													40	73					0	0	1	0	0	T	31833747	C	T	31833747	3	4	52	1	0	0	0	0	1	0	0	0	14692	536	19	1	774	1	SLC44A4	6	31833747	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		31833747	139281320	35	9158										
TREML2	79865	broad.mit.edu	37	chr6	41165846	41165846	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gagccactgcagcctgctcaCctggagacacatccagctgg	11	15	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:41165846C>T	ENST00000483722.1	-	2	562		c.e2+1			NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2						T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCCTGCTCACCTGGAGACAC	0.572													16	30					0	0	1	0	0	T	41165846	C	T	41165846	5	4	52	1	0	0	0	0	0	0	1	0	16533	521	18	3	604	3	TREML2	6	41165846	Splice_Site	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	9332099	41165846	129949221	36	9159										
EYS	346007	broad.mit.edu	37	chr6	66204707	66204707	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aatggaggctggcaatggcaGctatatgtcttgctccaagc	12	9	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:66204707G>C	ENST00000503581.1	-	4	1134	c.597C>G	c.(595-597)agC>agG	p.S199R	EYS_ENST00000393380.2_Missense_Mutation_p.S199R|EYS_ENST00000370616.2_Missense_Mutation_p.S199R|EYS_ENST00000370618.3_Missense_Mutation_p.S199R|EYS_ENST00000370621.3_Missense_Mutation_p.S199R|EYS_ENST00000342421.5_Missense_Mutation_p.S199R	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	199	EGF-like 1.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GGCAATGGCAGCTATATGTCT	0.398													9	37					0	0	1	0	0	C	66204707	G	C	66204707	3	2	52	1	0	0	0	0	1	0	0	0	5360	962	34	5	8959	5	EYS	6	66204707	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	25038861	66204707	104910360	37	9160										
MDN1	23195	broad.mit.edu	37	chr6	90432736	90432736	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	caaaaacacatgctgaccagGatcataacacccaggggact	8	12	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:90432736G>C	ENST00000369393.3	-	40	6020	c.5905C>G	c.(5905-5907)Cct>Gct	p.P1969A	MDN1_ENST00000428876.1_Missense_Mutation_p.P1969A			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1969					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TGCTGACCAGGATCATAACAC	0.468													34	247					0	0	1	0	0	C	90432736	G	C	90432736	3	2	52	1	0	0	0	0	1	0	0	0	9464	1174	41	2	11137	2	MDN1	6	90432736	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	24228029	90432736	80682331	38	9161										
AKAP12	9590	broad.mit.edu	37	chr6	151670243	151670244	+	Frame_Shift_Ins	INS	-	-	T													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aacaatctacagagaaacccINSgaagagaccctgaagcgtga							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:151670243_151670244insT	ENST00000402676.2	+	4	957_958	c.717_718insT	c.(715-720)ccaagafs	p.R240fs	AKAP12_ENST00000253332.1_Frame_Shift_Ins_p.R240fs|AKAP12_ENST00000354675.6_Frame_Shift_Ins_p.R142fs|AKAP12_ENST00000490177.1_3'UTR|AKAP12_ENST00000359755.5_Frame_Shift_Ins_p.R135fs	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	240			E -> K (in a colorectal cancer sample; somatic mutation).		G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding	p.E240K(2)		breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CAGAGAAACCCGAAGAGACCCT	0.559													25	245	---	---	---	---						T	151670244	-	T	151670243	7	5	52	1	0	1	1	0	0	0	0	0	445	639	23	0	756	0	AKAP12	6	151670243	Frame_Shift_Ins	INS	-	TCGA-NF-A4X2-01A-11D-A28R-08	61237507	151670243	19444824	39	9162										
IGF2R	3482	broad.mit.edu	37	chr6	160468851	160468851	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ataactccacctacaacttcCggtggtacaccagctatgcc	6	15	0	0	rs146539241		TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:160468851C>T	ENST00000356956.1	+	17	2405	c.2257C>T	c.(2257-2259)Cgg>Tgg	p.R753W		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	753					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CTACAACTTCCGGTGGTACAC	0.547													49	109					0	0	1	0	0	T	160468851	C	T	160468851	3	4	52	1	0	0	0	0	1	0	0	0	7619	643	23	1	2323	1	IGF2R	6	160468851	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	8798608	160468851	10646216	40	9163										
MAP3K4	4216	broad.mit.edu	37	chr6	161507690	161507691	+	Frame_Shift_Ins	INS	-	-	T													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	atgttctgaaatcaaaacagINStatgtcaaggtaagtacttc							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr6:161507690_161507691insT	ENST00000392142.4	+	9	2695_2696	c.2547_2548insT	c.(2545-2550)caatgtfs	p.QC849fs	MAP3K4_ENST00000366920.2_Frame_Shift_Ins_p.QC849fs|MAP3K4_ENST00000366919.2_Frame_Shift_Ins_p.QC849fs|MAP3K4_ENST00000348824.7_Frame_Shift_Ins_p.QC849fs	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	849					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AATCAAAACAGTATGTCAAGGT	0.381													19	29	---	---	---	---						T	161507691	-	T	161507690	7	5	52	1	0	1	1	0	0	0	0	0	9301	1020	36	0	2581	0	MAP3K4	6	161507690	Frame_Shift_Ins	INS	-	TCGA-NF-A4X2-01A-11D-A28R-08	1038839	161507690	9607377	41	9164										
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26235493	26235493	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtcctcctccatacccattaTagccatccccaaatccacgt	3	18	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr7:26235493T>C	ENST00000354667.4	-	8	899	c.731A>G	c.(730-732)tAt>tGt	p.Y244C	HNRNPA2B1_ENST00000356674.7_Missense_Mutation_p.Y232C	NM_031243.2	NP_112533.1	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	244	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding|single-stranded telomeric DNA binding		HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						ATACCCATTATAGCCATCCCC	0.363			T	ETV1	prostate								54	19					0	0	1	0	0	C	26235493	T	C	26235493	3	2	52	1	0	0	0	0	1	0	0	0	7299	1406	49	4	346	4	HNRNPA2B1	7	26235493	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08		26235493	132903170	42	9165										
PKD1L1	168507	broad.mit.edu	37	chr7	47898380	47898380	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tggatatgagaccgatgagcTcaagcctcactcctttgtca	9	11	3	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr7:47898380T>G	ENST00000289672.2	-	27	4303	c.4253A>C	c.(4252-4254)gAg>gCg	p.E1418A		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1418	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						ACCGATGAGCTCAAGCCTCAC	0.493													20	94					0	0	1	0	0	G	47898380	T	G	47898380	3	3	52	1	0	0	0	0	1	0	0	0	12011	1551	54	4	4420	4	PKD1L1	7	47898380	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	21662887	47898380	111240283	43	9166										
MUC17	140453	broad.mit.edu	37	chr7	100682628	100682628	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tatacttgtcagcaccatgcCagtggccagttctgaggcta	10	11	2	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr7:100682628C>T	ENST00000306151.4	+	3	7995	c.7931C>T	c.(7930-7932)cCa>cTa	p.P2644L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2644	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACCATGCCAGTGGCCAGT	0.463													133	523					0	0	1	0	0	T	100682628	C	T	100682628	3	4	52	1	0	0	0	0	1	0	0	0	10021	594	21	3	7941	3	MUC17	7	100682628	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	52784248	100682628	58456035	44	9167										
NAPEPLD	222236	broad.mit.edu	37	chr7	102760563	102760563	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcatccatttccaccattacCgtggcatgtcccagccatgt	6	15	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr7:102760563C>T	ENST00000417955.1	-	3	556	c.402G>A	c.(400-402)acG>acA	p.T134T	NAPEPLD_ENST00000455523.2_Silent_p.T207T|NAPEPLD_ENST00000465647.1_Silent_p.T134T|NAPEPLD_ENST00000341533.4_Silent_p.T134T|NAPEPLD_ENST00000427257.1_Silent_p.T134T			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	134					phospholipid catabolic process	membrane	metal ion binding			endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						CCACCATTACCGTGGCATGTC	0.478													52	63					0	0	1	0	0	T	102760563	C	T	102760563	2	4	52	1	0	0	0	0	0	0	0	1	10210	639	23	1		1	NAPEPLD	7	102760563	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	2077935	102760563	56378100	45	9168										
C7orf49	78996	broad.mit.edu	37	chr7	134851483	134851483	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gaagggctgaggcctggagcCagtgcctgtttcccactgtc	14	12	0	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr7:134851483C>A	ENST00000424142.1	-	4	791	c.189G>T	c.(187-189)ctG>ctT	p.L63L	C7orf49_ENST00000483029.2_Silent_p.L63L|C7orf49_ENST00000393114.3_Silent_p.L118L|C7orf49_ENST00000459937.1_Intron|C7orf49_ENST00000430372.1_Silent_p.L117L	NM_001243749.1|NM_001243753.1	NP_001230678.1|NP_001230682.1	Q9BWK5	MRI_HUMAN	chromosome 7 open reading frame 49	118						cytoplasm				endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						GGCCTGGAGCCAGTGCCTGTT	0.627													29	79					1.80694e-10	2.05269e-10	1	1	0	A	134851483	C	A	134851483	2	1	52	1	0	0	0	0	0	0	0	1	2414	581	21	5		5	C7orf49	7	134851483	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	32090920	134851483	24287180	46	9169										
LOXL2	4017	broad.mit.edu	37	chr8	23167294	23167294	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agccggcggtagcccgtggtGgggtcggtctgcgcggctga	20	11	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr8:23167294G>A	ENST00000389131.3	-	10	2136	c.1767C>T	c.(1765-1767)ccC>ccT	p.P589P		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	589	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		AGCCCGTGGTGGGGTCGGTCT	0.662													8	48					0	0	1	0	0	A	23167294	G	A	23167294	2	1	52	1	0	0	0	0	0	0	0	1	8944	1335	47	3		3	LOXL2	8	23167294	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08		23167294	123196728	47	9170										
GDF6	392255	broad.mit.edu	37	chr8	97172606	97172606	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cccagcttctcagcgatggaGtaagtcctgtagattgacag	11	10	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr8:97172606G>C	ENST00000287020.5	-	1	414	c.315C>G	c.(313-315)taC>taG	p.Y105*		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	105					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					CAGCGATGGAGTAAGTCCTGT	0.597													56	199					0	0	1	0	0	C	97172606	G	C	97172606	4	2	52	1	0	0	0	0	0	1	0	0	6358	1024	36	5	1060	5	GDF6	8	97172606	Nonsense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	74005312	97172606	49191416	48	9171										
VPS13B	157680	broad.mit.edu	37	chr8	100887728	100887728	+	Frame_Shift_Del	DEL	C	C	-													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aaagacatcttgtcacctggCccccagctgttcttccatgc							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr8:100887728delC	ENST00000358544.2	+	62	12014	c.11903delC	c.(11902-11904)gcfs	p.A3968fs	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Frame_Shift_Del_p.A3943fs	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3968					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGTCACCTGGCCCCCAGCTGT	0.478													29	123	---	---	---	---						-	100887728	C	-	100887728	7	5	52	1	0	1	0	1	0	0	0	0	17249	739	26	0	12339	0	VPS13B	8	100887728	Frame_Shift_Del	DEL	C	TCGA-NF-A4X2-01A-11D-A28R-08	3715122	100887728	45476294	49	9172										
CTHRC1	115908	broad.mit.edu	37	chr8	104388056	104388056	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttccgggtacacctgggatcCcaggtcgggatggattcaaa	13	10	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr8:104388056C>G	ENST00000330295.5	+	2	383	c.241C>G	c.(241-243)Cca>Gca	p.P81A	CTHRC1_ENST00000415886.2_Missense_Mutation_p.P81A|CTHRC1_ENST00000520337.1_Missense_Mutation_p.P67A	NM_138455.3	NP_612464.1	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	81	Collagen-like.					collagen				endometrium(1)|large_intestine(5)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			ACCTGGGATCCCAGGTCGGGA	0.527													18	123					0	0	1	0	0	G	104388056	C	G	104388056	3	3	52	1	0	0	0	0	1	0	0	0	4034	623	22	5	247	5	CTHRC1	8	104388056	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	3500328	104388056	41975966	50	9173										
SYBU	55638	broad.mit.edu	37	chr8	110588205	110588205	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aatccagtcctctcgcatgcGggccagctgggacttaagct	11	13	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr8:110588205G>T	ENST00000399066.3	-	6	1640	c.913C>A	c.(913-915)Cgc>Agc	p.R305S	SYBU_ENST00000528647.1_Missense_Mutation_p.R307S|SYBU_ENST00000533065.1_Missense_Mutation_p.R189S|SYBU_ENST00000529690.1_Missense_Mutation_p.R178S|SYBU_ENST00000533895.1_Missense_Mutation_p.R307S|SYBU_ENST00000422135.1_Missense_Mutation_p.R308S|SYBU_ENST00000529175.1_Missense_Mutation_p.R102S|SYBU_ENST00000527707.1_5'UTR|SYBU_ENST00000446070.2_Missense_Mutation_p.R307S|SYBU_ENST00000408908.2_Missense_Mutation_p.R308S|SYBU_ENST00000424158.2_Missense_Mutation_p.R313S|SYBU_ENST00000440310.1_Missense_Mutation_p.R308S|SYBU_ENST00000433638.1_Missense_Mutation_p.R308S|SYBU_ENST00000276646.9_Missense_Mutation_p.R308S|SYBU_ENST00000419099.1_Missense_Mutation_p.R307S|SYBU_ENST00000528331.1_Missense_Mutation_p.R189S|SYBU_ENST00000408889.3_Missense_Mutation_p.R189S|SYBU_ENST00000533171.1_Missense_Mutation_p.R308S|SYBU_ENST00000532779.1_Missense_Mutation_p.R240S	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	308	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						TCTCGCATGCGGGCCAGCTGG	0.433													24	66					2.21704e-12	2.58048e-12	1	1	0	T	110588205	G	T	110588205	3	4	52	1	0	0	0	0	1	0	0	0	15482	1116	39	5	1073	5	SYBU	8	110588205	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	6200149	110588205	35775817	51	9174										
COL22A1	169044	broad.mit.edu	37	chr8	139824130	139824130	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gaggccgctggggtgggggtGgaggtggaggctctgtcacc	22	8	2	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr8:139824130G>T	ENST00000303045.6	-	9	1807	c.1361C>A	c.(1360-1362)cCa>cAa	p.P454Q	COL22A1_ENST00000435777.1_Missense_Mutation_p.P454Q	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	454	Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGTGGGGGTGGAGGTGGAGG	0.597										HNSCC(7;0.00092)			11	9					3.86212e-05	4.1547e-05	1	1	0	T	139824130	G	T	139824130	3	4	52	1	0	0	0	0	1	0	0	0	3704	1348	47	5	3747	5	COL22A1	8	139824130	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	29235925	139824130	6539892	52	9175										
LINGO2	158038	broad.mit.edu	37	chr9	27949585	27949585	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gctgcaagatccagagaaggCggcagtcacaggccagaggg	16	10	1	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:27949585C>T	ENST00000379992.2	-	6	1534	c.1085G>A	c.(1084-1086)cGc>cAc	p.R362H	LINGO2_ENST00000308675.3_Missense_Mutation_p.R362H	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	362	LRRCT.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CCAGAGAAGGCGGCAGTCACA	0.547													33	6					0	0	1	0	0	T	27949585	C	T	27949585	3	4	52	1	0	0	0	0	1	0	0	0	8855	768	27	1	739	1	LINGO2	9	27949585	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		27949585	113263846	53	9176										
TRPM3	80036	broad.mit.edu	37	chr9	73736211	73736211	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tccaaattccaccaggaaaaCaagaaactgaaaacctgagc	6	11	0	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:73736211C>A	ENST00000377110.2	-	1	303	c.60G>T	c.(58-60)ttG>ttT	p.L20F	TRPM3_ENST00000357533.2_Intron|TRPM3_ENST00000377111.2_Missense_Mutation_p.L20F|TRPM3_ENST00000423814.3_Intron	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	20						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						ACCAGGAAAACAAGAAACTGA	0.512													82	6					1.26005e-42	1.59757e-42	1	1	0	A	73736211	C	A	73736211	3	1	52	1	0	0	0	0	1	0	0	0	16647	477	17	5	5286	5	TRPM3	9	73736211	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	45786626	73736211	67477220	54	9177										
WNK2	65268	broad.mit.edu	37	chr9	96021235	96021245	+	Frame_Shift_Del	DEL	CCCCCATCACG	CCCCCATCACG	-													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gcccccgattcctgttgtgcCccccatcacgcccctggcgg					rs149576658		TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:96021235_96021245delCCCCCATCACG	ENST00000297954.4	+	11	2405_2415	c.2405_2415delCCCCCATCACG	c.(2404-2415)cfs	p.PPIT802fs	WNK2_ENST00000349097.3_Frame_Shift_Del_p.PPIT414fs|WNK2_ENST00000427277.2_Frame_Shift_Del_p.PPIT414fs|WNK2_ENST00000395475.2_Frame_Shift_Del_p.PPIT736fs|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000395477.2_Frame_Shift_Del_p.PPIT802fs			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	802					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCTGTTGTGCCCCCCATCACGCCCCTGGCGG	0.649													13	33	---	---	---	---						-	96021245	CCCCCATCACG	-	96021235	7	5	52	1	0	1	0	1	0	0	0	0	17437	623	22	0	2447	0	WNK2	9	96021235	Frame_Shift_Del	DEL	CCCCCATCACG	TCGA-NF-A4X2-01A-11D-A28R-08	22285024	96021235	45192196	55	9178										
SVEP1	79987	broad.mit.edu	37	chr9	113312294	113312294	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tgaatctcgcagtgacgctgCaattggtctagggtctcccc	11	12	3	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:113312294C>A	ENST00000401783.2	-	2	958	c.622G>T	c.(622-624)Gca>Tca	p.A208S	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374461.1_Missense_Mutation_p.A185S|SVEP1_ENST00000302728.8_Missense_Mutation_p.A208S|SVEP1_ENST00000374469.1_Missense_Mutation_p.A185S	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	208	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AGTGACGCTGCAATTGGTCTA	0.443													23	85					6.44725e-10	7.15242e-10	1	1	0	A	113312294	C	A	113312294	3	1	52	1	0	0	0	0	1	0	0	0	15475	710	25	5	10281	5	SVEP1	9	113312294	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	17291059	113312294	27901137	56	9179										
COL27A1	85301	broad.mit.edu	37	chr9	117068960	117068960	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	catggactgtgagcagaagaTggtggatggtgagaaggctt	17	4	0	4			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:117068960T>G	ENST00000356083.3	+	58	5490	c.5099T>G	c.(5098-5100)aTg>aGg	p.M1700R		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1700	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GAGCAGAAGATGGTGGATGGT	0.607											OREG0019417	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	39					0	0	1	0	0	G	117068960	T	G	117068960	3	3	52	1	0	0	0	0	1	0	0	0	3708	1464	51	4	5329	4	COL27A1	9	117068960	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	3756666	117068960	24144471	57	9180										
ASTN2	23245	broad.mit.edu	37	chr9	119582946	119582946	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gcatcgtagggcaggggcagCgtctgctgcaggcacagctg	17	11	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:119582946C>T	ENST00000313400.4	-	12	2257	c.2157G>A	c.(2155-2157)acG>acA	p.T719T	ASTN2_ENST00000361209.2_Silent_p.T668T|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Silent_p.T715T			O75129	ASTN2_HUMAN	astrotactin 2	719	EGF-like 3.					integral to membrane		p.T668T(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GCAGGGGCAGCGTCTGCTGCA	0.577													115	11					0	0	1	0	0	T	119582946	C	T	119582946	2	4	52	1	0	0	0	0	0	0	0	1	1064	755	27	1		1	ASTN2	9	119582946	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	2513986	119582946	21630485	58	9181										
C9orf9	11092	broad.mit.edu	37	chr9	135762851	135762851	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcagagctgaataagctctgCcagcactttgaggccgtgca	11	11	2	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr9:135762851C>T	ENST00000372136.3	+	3	687	c.240C>T	c.(238-240)tgC>tgT	p.C80C	C9orf9_ENST00000356311.5_Silent_p.C80C|C9orf9_ENST00000350499.6_Silent_p.C80C			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	80								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		ATAAGCTCTGCCAGCACTTTG	0.537													31	225					0	0	1	0	0	T	135762851	C	T	135762851	2	4	52	1	0	0	0	0	0	0	0	1	2522	747	26	3		3	C9orf9	9	135762851	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	16179905	135762851	5450580	59	9182										
PIP4K2A	5305	broad.mit.edu	37	chr10	23003128	23003128	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttaccgagtggtttacccccCacatgaggacgctgagcagc	11	13	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:23003128C>A	ENST00000376573.4	-	1	356	c.128G>T	c.(127-129)tGg>tTg	p.W43L		NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	43	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						GTTTACCCCCCACATGAGGAC	0.627													19	31					1.96292e-10	2.21218e-10	1	1	0	A	23003128	C	A	23003128	3	1	52	1	0	0	0	0	1	0	0	0	11983	595	21	5	1132	5	PIP4K2A	10	23003128	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		23003128	112531619	60	9183										
YME1L1	10730	broad.mit.edu	37	chr10	27437875	27437875	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gctcaggaactacatctcgaTgctggttttgagaaactgac	10	9	2	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:27437875T>C	ENST00000326799.3	-	2	276	c.128A>G	c.(127-129)cAt>cGt	p.H43R	YME1L1_ENST00000477432.1_Missense_Mutation_p.H43R|YME1L1_ENST00000375972.3_Missense_Mutation_p.H43R|YME1L1_ENST00000376016.3_Missense_Mutation_p.H43R	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	43					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						TACATCTCGATGCTGGTTTTG	0.428													127	69					0	0	1	0	0	C	27437875	T	C	27437875	3	2	52	1	0	0	0	0	1	0	0	0	17546	1464	51	4	2269	4	YME1L1	10	27437875	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	4434747	27437875	108096872	61	9184										
SVIL	6840	broad.mit.edu	37	chr10	29843734	29843734	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	atgtgggggctggcagggtcGctggctctcatgtatcgagg	18	8	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:29843734G>A	ENST00000375398.2	-	7	587	c.138C>T	c.(136-138)agC>agT	p.S46S	SVIL_ENST00000355867.4_Silent_p.S46S|SVIL_ENST00000375400.3_Silent_p.S46S			O95425	SVIL_HUMAN	supervillin	46	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TGGCAGGGTCGCTGGCTCTCA	0.592													20	19					0	0	1	0	0	A	29843734	G	A	29843734	2	1	52	1	0	0	0	0	0	0	0	1	15476	1078	38	1		1	SVIL	10	29843734	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	2405859	29843734	105691013	62	9185										
PARD3	56288	broad.mit.edu	37	chr10	34400456	34400456	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtagttctgctcccaagagtCctgggagaccgagctggcat	13	11	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:34400456C>G	ENST00000374789.3	-	25	4037	c.3712G>C	c.(3712-3714)Gac>Cac	p.D1238H	PARD3_ENST00000374790.3_Missense_Mutation_p.D1178H|PARD3_ENST00000350537.4_Missense_Mutation_p.D1192H|PARD3_ENST00000545260.1_Missense_Mutation_p.D1148H|PARD3_ENST00000545693.1_Missense_Mutation_p.D1222H|PARD3_ENST00000346874.4_Missense_Mutation_p.D1201H|PARD3_ENST00000374794.3_Missense_Mutation_p.D1126H|PARD3_ENST00000374788.3_Missense_Mutation_p.D1235H	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1238					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TCCCAAGAGTCCTGGGAGACC	0.567													32	51					0	0	1	0	0	G	34400456	C	G	34400456	3	3	52	1	0	0	0	0	1	0	0	0	11489	855	30	2	362	2	PARD3	10	34400456	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	4556722	34400456	101134291	63	9186										
AIFM2	84883	broad.mit.edu	37	chr10	71874719	71874719	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cgctgcttcacagagttgacGatgttggccacggcgatgtt	13	10	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:71874719G>A	ENST00000307864.1	-	8	1140	c.927C>T	c.(925-927)atC>atT	p.I309I	AIFM2_ENST00000482166.1_5'UTR|AIFM2_ENST00000373248.1_Silent_p.I309I	NM_001198696.1|NM_032797.5	NP_001185625.1|NP_116186.1	Q9BRQ8	AIFM2_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 2	309					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|urinary_tract(2)	16						CAGAGTTGACGATGTTGGCCA	0.577													10	37					0	0	1	0	0	A	71874719	G	A	71874719	2	1	52	1	0	0	0	0	0	0	0	1	424	1048	37	1		1	AIFM2	10	71874719	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	37474263	71874719	63660028	64	9187										
PTEN	5728	broad.mit.edu	37	chr10	89692893	89692893	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tgcagcaattcactgtaaagCtggaaagggacgaactggtg	13	7	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:89692893C>A	ENST00000371953.3	+	5	1734	c.377C>A	c.(376-378)gCt>gAt	p.A126D		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	126	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.A126D(3)|p.A126V(2)|p.Y27fs*1(2)|p.A121_F145del(1)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CACTGTAAAGCTGGAAAGGGA	0.408		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			81	51					3.31034e-53	4.23485e-53	1	1	0	A	89692893	C	A	89692893	3	1	52	1	0	0	0	0	1	0	0	0	12786	797	28	5	395	5	PTEN	10	89692893	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	17818174	89692893	45841854	65	9188										
EXOC6	54536	broad.mit.edu	37	chr10	94688101	94688101	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ctgattttattttagggtgaCgaggaaacatttgaaaacta	9	4	0	3	rs75784691	byFrequency	TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:94688101C>G	ENST00000371552.4	+	9	908	c.879C>G	c.(877-879)gaC>gaG	p.D293E	EXOC6_ENST00000443748.2_Missense_Mutation_p.D275E|EXOC6_ENST00000371547.4_Missense_Mutation_p.D314E|EXOC6_ENST00000260762.6_Missense_Mutation_p.D298E	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	298					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TTTAGGGTGACGAGGAAACAT	0.333													17	43					0	0	1	0	0	G	94688101	C	G	94688101	3	3	52	1	0	0	0	0	1	0	0	0	5335	535	19	5	1018	5	EXOC6	10	94688101	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	4995208	94688101	40846646	66	9189										
MYOF	26509	broad.mit.edu	37	chr10	95162632	95162632	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cttaccaggttcatcataaaCaaatccaacatcaatctggg	5	11	4	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:95162632C>A	ENST00000371501.4	-	10	981	c.859G>T	c.(859-861)Gtt>Ttt	p.V287F	MYOF_ENST00000359263.4_Missense_Mutation_p.V287F|MYOF_ENST00000358334.5_Missense_Mutation_p.V287F|MYOF_ENST00000371502.4_Missense_Mutation_p.V287F|MYOF_ENST00000371489.1_Missense_Mutation_p.V287F			Q9NZM1	MYOF_HUMAN	myoferlin	287					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TCATCATAAACAAATCCAACA	0.299													6	22					0.00198382	0.00208668	1	1	0	A	95162632	C	A	95162632	3	1	52	1	0	0	0	0	1	0	0	0	10136	478	17	5	5506	5	MYOF	10	95162632	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	474531	95162632	40372115	67	9190										
PPRC1	23082	broad.mit.edu	37	chr10	103901271	103901271	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	actgttcccccacctcctttGcctccagcctccattgggag	7	18	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:103901271G>A	ENST00000278070.2	+	5	3045	c.3006G>A	c.(3004-3006)ttG>ttA	p.L1002L	PPRC1_ENST00000370012.1_5'UTR|PPRC1_ENST00000413464.2_Silent_p.L1002L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1002	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CACCTCCTTTGCCTCCAGCCT	0.562													7	73					0	0	1	0	0	A	103901271	G	A	103901271	2	1	52	1	0	0	0	0	0	0	0	1	12458	1310	46	3		3	PPRC1	10	103901271	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	8738639	103901271	31633476	68	9191										
SLC18A2	6571	broad.mit.edu	37	chr10	119003729	119003729	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tgtcccagtgaagacaaagaCctcctgaatgaaaacgtgca	9	10	0	5			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:119003729C>T	ENST00000298472.5	+	3	512	c.369C>T	c.(367-369)gaC>gaT	p.D123D	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	123					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	AAGACAAAGACCTCCTGAATG	0.527													21	85					0	0	1	0	0	T	119003729	C	T	119003729	2	4	52	1	0	0	0	0	0	0	0	1	14480	506	18	3		3	SLC18A2	10	119003729	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	15102458	119003729	16531018	69	9192										
PDZD8	118987	broad.mit.edu	37	chr10	119043162	119043162	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ctggatcctttcctctgtagGcaagcccctgtacagatcac	8	14	2	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr10:119043162G>A	ENST00000334464.5	-	5	3321	c.3082C>T	c.(3082-3084)Cct>Tct	p.P1028S		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1028					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		TCCTCTGTAGGCAAGCCCCTG	0.403													6	125					0	0	1	0	0	A	119043162	G	A	119043162	3	1	52	1	0	0	0	0	1	0	0	0	11751	1203	42	3	386	3	PDZD8	10	119043162	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	39433	119043162	16491585	70	9193										
SCUBE2	57758	broad.mit.edu	37	chr11	9074741	9074741	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acacacggggtgacacacttGtgggcaggagccccttcact	12	13	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr11:9074741G>T	ENST00000457346.2	-	12	1426	c.1352C>A	c.(1351-1353)aCa>aAa	p.T451K	SCUBE2_ENST00000450649.2_Intron|SCUBE2_ENST00000520467.1_Missense_Mutation_p.T451K|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000309263.3_Missense_Mutation_p.T451K			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	451						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TGACACACTTGTGGGCAGGAG	0.532													34	5					2.48696e-23	3.09779e-23	1	1	0	T	9074741	G	T	9074741	3	4	52	1	0	0	0	0	1	0	0	0	13998	1377	48	5	1782	5	SCUBE2	11	9074741	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08		9074741	125931775	71	9194										
MRGPRX3	117195	broad.mit.edu	37	chr11	18158857	18158857	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttcacggggctgacgtgcatCgtttcccttgtcgcgctgac	12	13	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr11:18158857C>T	ENST00000396275.2	+	3	469	c.108C>T	c.(106-108)atC>atT	p.I36I		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	36						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TGACGTGCATCGTTTCCCTTG	0.582													5	259					0	0	1	0	0	T	18158857	C	T	18158857	2	4	52	1	0	0	0	0	0	0	0	1	9816	874	31	1		1	MRGPRX3	11	18158857	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	9084116	18158857	116847659	72	9195										
ARRB1	408	broad.mit.edu	37	chr11	74985231	74985231	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agtgtgtagaccttgcagaaCgtcgagctgggtgccacagt	14	9	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr11:74985231C>A	ENST00000420843.2	-	11	898	c.801G>T	c.(799-801)acG>acT	p.T267T	ARRB1_ENST00000393505.4_Silent_p.T267T|ARRB1_ENST00000360025.3_Silent_p.T267T	NM_004041.4	NP_004032.2	P49407	ARRB1_HUMAN	arrestin, beta 1	267					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(4)|large_intestine(2)|lung(4)|prostate(1)	11						CCTTGCAGAACGTCGAGCTGG	0.597													33	239					2.47316e-13	2.90238e-13	1	1	0	A	74985231	C	A	74985231	2	1	52	1	0	0	0	0	0	0	0	1	979	523	19	5		5	ARRB1	11	74985231	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	56826374	74985231	60021285	73	9196										
EXPH5	23086	broad.mit.edu	37	chr11	108385313	108385313	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttcttttgcacataatcttcTttaaagactctgggctccct	5	11	4	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr11:108385313T>C	ENST00000265843.4	-	6	1031	c.921A>G	c.(919-921)aaA>aaG	p.K307K	EXPH5_ENST00000525344.1_Silent_p.K300K|EXPH5_ENST00000443411.1_Silent_p.K119K|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000428840.1_Silent_p.K231K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	307					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CATAATCTTCTTTAAAGACTC	0.438													12	23					0	0	1	0	0	C	108385313	T	C	108385313	2	2	52	1	0	0	0	0	0	0	0	1	5350	1606	56	4		4	EXPH5	11	108385313	Silent	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	33400082	108385313	26621203	74	9197										
GIT2	9815	broad.mit.edu	37	chr12	110397663	110397663	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agcagttaccttttgaacccGagagagaactgccctgctgt	10	11	0	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr12:110397663G>A	ENST00000360185.4	-	12	1252	c.1088C>T	c.(1087-1089)tCg>tTg	p.S363L	GIT2_ENST00000547815.1_Missense_Mutation_p.S363L|GIT2_ENST00000553118.1_Missense_Mutation_p.S363L|GIT2_ENST00000355312.3_Missense_Mutation_p.S363L|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000551209.1_Missense_Mutation_p.S362L|GIT2_ENST00000356259.4_Missense_Mutation_p.S363L|GIT2_ENST00000354574.4_Missense_Mutation_p.S365L|GIT2_ENST00000338373.5_Missense_Mutation_p.S363L|GIT2_ENST00000320063.9_Missense_Mutation_p.S363L|GIT2_ENST00000457474.2_Missense_Mutation_p.S365L|GIT2_ENST00000361006.5_Missense_Mutation_p.S363L|GIT2_ENST00000343646.5_Intron			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	363					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						TTTTGAACCCGAGAGAGAACT	0.453													5	32					0	0	1	0	0	A	110397663	G	A	110397663	3	1	52	1	0	0	0	0	1	0	0	0	6438	1059	37	1	1255	1	GIT2	12	110397663	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08		110397663	23454232	75	9198										
CUX2	23316	broad.mit.edu	37	chr12	111785693	111785693	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tccgggtaatgatggactccCaaaagtggctcccgggcccc	12	14	0	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr12:111785693C>G	ENST00000261726.6	+	22	4179	c.4025C>G	c.(4024-4026)cCa>cGa	p.P1342R		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1342	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GATGGACTCCCAAAAGTGGCT	0.642													42	145					0	0	1	0	0	G	111785693	C	G	111785693	3	3	52	1	0	0	0	0	1	0	0	0	4088	594	21	5	4111	5	CUX2	12	111785693	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	1388030	111785693	22066202	76	9199										
NOS1	4842	broad.mit.edu	37	chr12	117703237	117703237	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtcggcagggcagcccccccGgcagcggtactcattctcca	12	17	2	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr12:117703237G>A	ENST00000317775.6	-	12	2705	c.2020C>T	c.(2020-2022)Cgg>Tgg	p.R674W	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R674W	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	674					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CAGCCCCCCCGGCAGCGGTAC	0.607													9	8					0	0	1	0	0	A	117703237	G	A	117703237	3	1	52	1	0	0	0	0	1	0	0	0	10587	1115	39	1	2356	1	NOS1	12	117703237	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	5917544	117703237	16148658	77	9200										
NBEA	26960	broad.mit.edu	37	chr13	36242543	36242543	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gacggccagaacctggtcacCggaggggacaatggggtagt	17	9	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr13:36242543C>T	ENST00000400445.3	+	57	9171	c.8637C>T	c.(8635-8637)acC>acT	p.T2879T	NBEA_ENST00000310336.4_Silent_p.T2879T|NBEA_ENST00000379939.2_Silent_p.T2876T|NBEA_ENST00000537702.1_Silent_p.T672T|NBEA_ENST00000379922.3_Silent_p.T457T|NBEA_ENST00000540320.1_Silent_p.T2879T	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2879						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACCTGGTCACCGGAGGGGACA	0.443													14	0					0	0	1	0	0	T	36242543	C	T	36242543	2	4	52	1	0	0	0	0	0	0	0	1	10234	639	23	1		1	NBEA	13	36242543	Silent	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		36242543	78927335	78	9201										
FNDC3A	22862	broad.mit.edu	37	chr13	49775991	49775991	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acaaagtacaaagacttaatGagtcaacatcctataaattc	4	8	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr13:49775991G>A	ENST00000492622.2	+	24	3348	c.3043G>A	c.(3043-3045)Gag>Aag	p.E1015K	FNDC3A_ENST00000398316.3_Missense_Mutation_p.E959K|FNDC3A_ENST00000541916.1_Missense_Mutation_p.E1015K	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1015	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		AAGACTTAATGAGTCAACATC	0.358													32	8					0	0	1	0	0	A	49775991	G	A	49775991	3	1	52	1	0	0	0	0	1	0	0	0	6001	1291	45	3	3144	3	FNDC3A	13	49775991	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	13533448	49775991	65393887	79	9202										
ATP11A	23250	broad.mit.edu	37	chr13	113488914	113488914	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcattgcagacttggctttaCctacctaaggctgaaggaca	9	10	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr13:113488914C>T	ENST00000487903.1	+	15	1659	c.1571C>T	c.(1570-1572)aCc>aTc	p.T524I	ATP11A_ENST00000283558.8_Missense_Mutation_p.T524I|ATP11A_ENST00000375630.2_Missense_Mutation_p.T524I|ATP11A_ENST00000375645.3_Missense_Mutation_p.T524I			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	524					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTTGGCTTTACCTACCTAAGG	0.423													49	214					0	0	1	0	0	T	113488914	C	T	113488914	3	4	52	1	0	0	0	0	1	0	0	0	1118	507	18	3	1629	3	ATP11A	13	113488914	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	63712923	113488914	1680964	80	9203										
LRFN5	145581	broad.mit.edu	37	chr14	42360910	42360910	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acaatgtgattcaatcttcaGaaacttgttcgagtcaggac	8	8	4	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr14:42360910G>T	ENST00000298119.4	+	4	3032	c.1843G>T	c.(1843-1845)Gaa>Taa	p.E615*	LRFN5_ENST00000554171.1_Intron|LRFN5_ENST00000554120.1_Intron	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	615						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TCAATCTTCAGAAACTTGTTC	0.483										HNSCC(30;0.082)			16	36					0.000308642	0.000329528	1	1	0	T	42360910	G	T	42360910	4	4	52	1	0	0	0	0	0	1	0	0	8985	943	33	2	1849	2	LRFN5	14	42360910	Nonsense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08		42360910	64988630	81	9204										
RCN2	5955	broad.mit.edu	37	chr15	77224706	77224706	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcgcttccccctaaaggaagAtgtggatgaatatgttaaac	9	8	0	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr15:77224706A>C	ENST00000394885.3	+	2	372	c.149A>C	c.(148-150)gAt>gCt	p.D50A	RCN2_ENST00000394883.3_Intron|RCN2_ENST00000320963.5_Missense_Mutation_p.D50A	NM_002902.2	NP_002893.1	Q14257	RCN2_HUMAN	reticulocalbin 2, EF-hand calcium binding domain	50						endoplasmic reticulum lumen	calcium ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(1)	7						CTAAAGGAAGATGTGGATGAA	0.473													15	7					0	0	1	0	0	C	77224706	A	C	77224706	3	2	52	1	0	0	0	0	1	0	0	0	13231	333	12	4	155	4	RCN2	15	77224706	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08		77224706	25306686	82	9205										
MESDC1	59274	broad.mit.edu	37	chr15	81294956	81294956	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gggggacagcctggtggagcTgggcgacctggtggtgtcgc	21	9	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr15:81294956T>C	ENST00000267984.2	+	1	1662	c.344T>C	c.(343-345)cTg>cCg	p.L115P		NM_022566.2	NP_072088.1	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	115										endometrium(1)|lung(2)	3						CTGGTGGAGCTGGGCGACCTG	0.726													3	16					0	0	1	0	0	C	81294956	T	C	81294956	3	2	52	1	0	0	0	0	1	0	0	0	9529	1580	55	4	346	4	MESDC1	15	81294956	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	4070250	81294956	21236436	83	9206										
CACNA1H	8912	broad.mit.edu	37	chr16	1251811	1251811	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggccagcttctccgagcctgGcagctgctacgaagagctgc	13	14	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr16:1251811G>A	ENST00000348261.5	+	9	1609	c.1361G>A	c.(1360-1362)gGc>gAc	p.G454D	CACNA1H_ENST00000358590.4_Missense_Mutation_p.G454D|CACNA1H_ENST00000565831.1_Missense_Mutation_p.G454D	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	454					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCCGAGCCTGGCAGCTGCTAC	0.657													12	0					0	0	1	0	0	A	1251811	G	A	1251811	3	1	52	1	0	0	0	0	1	0	0	0	2563	1203	42	3	1391	3	CACNA1H	16	1251811	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08		1251811	89102942	84	9207										
TPSB2	64499	broad.mit.edu	37	chr16	1278514	1278514	+	RNA	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ggctcagaagagagcaggggGcttaggacaggaaggggcac	19	7	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr16:1278514G>A	ENST00000430512.2	-	0	1012				TPSB2_ENST00000339687.6_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				AGAGCAGGGGGCTTAGGACAG	0.662													4	10					0	0	1	0	0	A	1278514	G	A	1278514	1	1	52	0	1	0	0	0	0	0	0	0	16484	1218	42	3		3	TPSB2	16	1278514	RNA	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	26703	1278514	89076239	85	9208										
XAF1	54739	broad.mit.edu	37	chr17	6676464	6676464	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tggttagcttcatcaaaaggAaaacaagtgagaaatttcag	9	5	3	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr17:6676464A>G	ENST00000361842.3	+	7	1121	c.882A>G	c.(880-882)ggA>ggG	p.G294G	XAF1_ENST00000441631.1_Silent_p.G294G|XAF1_ENST00000346752.4_Silent_p.G275G	NM_017523.3	NP_059993.2	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1	294					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding			large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	6						CATCAAAAGGAAAACAAGTGA	0.353													5	19					0	0	1	0	0	G	6676464	A	G	6676464	2	3	52	1	0	0	0	0	0	0	0	1	17478	233	9	4		4	XAF1	17	6676464	Silent	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08		6676464	74518746	86	9209										
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr17:7577120C>T	ENST00000420246.2	-	8	950	c.818G>A	c.(817-819)cGt>cAt	p.R273H	TP53_ENST00000269305.4_Missense_Mutation_p.R273H|TP53_ENST00000445888.2_Missense_Mutation_p.R273H|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R273H|TP53_ENST00000359597.4_Missense_Mutation_p.R273H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	0					0	0	1	0	0	T	7577120	C	T	7577120	3	4	52	1	0	0	0	0	1	0	0	0	16441	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	900656	7577120	73618090	87	9210										
ALOX15B	247	broad.mit.edu	37	chr17	7950683	7950683	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cttctccaagggcttcctaaAccaggagagctcaggtacag	10	12	2	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr17:7950683A>T	ENST00000380183.4	+	11	1704	c.1565A>T	c.(1564-1566)aAc>aTc	p.N522I	ALOX15B_ENST00000380173.2_Missense_Mutation_p.N493I|ALOX15B_ENST00000572022.1_Missense_Mutation_p.N510I|ALOX15B_ENST00000573359.1_Intron	NM_001141.2	NP_001132.2	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, type B	522	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	24						GGCTTCCTAAACCAGGAGAGC	0.567													8	34					0	0	1	0	0	T	7950683	A	T	7950683	3	4	52	1	0	0	0	0	1	0	0	0	535	43	2	4	1607	4	ALOX15B	17	7950683	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08	373563	7950683	73244527	88	9211										
HS3ST3A1	9955	broad.mit.edu	37	chr17	13504291	13504291	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ccgccggacagccccacgacGgggccggacagggtctggca	16	16	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr17:13504291G>A	ENST00000284110.1	-	1	953	c.156C>T	c.(154-156)ccC>ccT	p.P52P		NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	52						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCCCCACGACGGGGCCGGACA	0.726													3	4					0	0	1	0	0	A	13504291	G	A	13504291	2	1	52	1	0	0	0	0	0	0	0	1	7405	1103	39	1		1	HS3ST3A1	17	13504291	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	5553608	13504291	67690919	89	9212										
FAM83G	644815	broad.mit.edu	37	chr17	18881910	18881910	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gatcttggcaatctcgtcgaCgctcttggccttgacaagtg	11	11	3	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr17:18881910C>A	ENST00000388995.6	-	5	1292	c.1069G>T	c.(1069-1071)Gtc>Ttc	p.V357F	SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395647.2_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.V357F|SLC5A10_ENST00000317977.6_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.V357F|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000417251.2_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	357										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						ATCTCGTCGACGCTCTTGGCC	0.627													34	58					6.00712e-18	7.2907e-18	1	1	0	A	18881910	C	A	18881910	3	1	52	1	0	0	0	0	1	0	0	0	5670	536	19	5	1410	5	FAM83G	17	18881910	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	5377619	18881910	62313300	90	9213										
CORO6	84940	broad.mit.edu	37	chr17	27945807	27945807	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gtggccaggccaggcactcaCcgccaccacttggccttttc	10	17	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr17:27945807C>G	ENST00000345068.5	-	5	847		c.e5+1		CORO6_ENST00000445145.2_Splice_Site|CORO6_ENST00000584969.1_Splice_Site|CORO6_ENST00000388767.3_Splice_Site|CORO6_ENST00000580212.1_Splice_Site|RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000577909.1_Intron			Q6QEF8	CORO6_HUMAN	coronin 6						actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						CAGGCACTCACCGCCACCACT	0.602													15	25					0	0	1	0	0	G	27945807	C	G	27945807	5	3	52	1	0	0	0	0	0	0	1	0	3781	521	18	5	812	5	CORO6	17	27945807	Splice_Site	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	9063897	27945807	53249403	91	9214										
CDH2	1000	broad.mit.edu	37	chr18	25585840	25585840	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tgatccctcaggaactgtccCattccaaacctggtgtaaga	8	12	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr18:25585840C>A	ENST00000269141.3	-	6	1243	c.820G>T	c.(820-822)Ggg>Tgg	p.G274W	CDH2_ENST00000399380.3_Missense_Mutation_p.G243W	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	274	Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GGAACTGTCCCATTCCAAACC	0.388													28	106					1.55811e-20	1.90734e-20	1	1	0	A	25585840	C	A	25585840	3	1	52	1	0	0	0	0	1	0	0	0	3127	594	21	5	1944	5	CDH2	18	25585840	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		25585840	52491408	92	9215										
SLC14A2	8170	broad.mit.edu	37	chr18	43252989	43252989	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttgcttgcatgcagcaattgGatccaccatggggatgctag	12	9	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr18:43252989G>T	ENST00000255226.6	+	17	3170	c.2354G>T	c.(2353-2355)gGa>gTa	p.G785V	SLC14A2_ENST00000586448.1_Missense_Mutation_p.G785V|SLC14A2_ENST00000589658.1_Missense_Mutation_p.G262V|RP11-116O18.3_ENST00000589510.1_RNA	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	785						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GCAGCAATTGGATCCACCATG	0.527													37	122					1.47197e-15	1.77135e-15	1	1	0	T	43252989	G	T	43252989	3	4	52	1	0	0	0	0	1	0	0	0	14451	1174	41	2	2416	2	SLC14A2	18	43252989	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	17667149	43252989	34824259	93	9216										
ARHGEF18	23370	broad.mit.edu	37	chr19	7534894	7534894	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gccctatcctgcccggcagaCacagtcctgcgcccccacca	8	21	0	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:7534894C>A	ENST00000359920.6	+	18	3581	c.3328C>A	c.(3328-3330)Cac>Aac	p.H1110N	CTD-2207O23.3_ENST00000593531.1_Missense_Mutation_p.D1067E|ARHGEF18_ENST00000319670.9_Missense_Mutation_p.H952N	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	1110	Pro-rich.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				GCCCGGCAGACACAGTCCTGC	0.662													4	108					0.150653	0.151722	1	1	0	A	7534894	C	A	7534894	3	1	52	1	0	0	0	0	1	0	0	0	898	478	17	5	3398	5	ARHGEF18	19	7534894	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		7534894	51594089	94	9217										
C19orf59	199675	broad.mit.edu	37	chr19	7743070	7743070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ccatcctgagcctgtacatcCtcctggccctggcctttgtc	8	17	0	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:7743070C>T	ENST00000333598.3	+	3	719	c.265C>T	c.(265-267)Ctc>Ttc	p.L89F	C19orf59_ENST00000597445.1_Missense_Mutation_p.L46F	NM_174918.2	NP_777578.2	Q8IX19	MCEM1_HUMAN	chromosome 19 open reading frame 59	89						integral to membrane				endometrium(1)|lung(2)|skin(1)|stomach(1)	5						CCTGTACATCCTCCTGGCCCT	0.592											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	188					0	0	1	0	0	T	7743070	C	T	7743070	3	4	52	1	0	0	0	0	1	0	0	0	1952	681	24	3	275	3	C19orf59	19	7743070	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	208176	7743070	51385913	95	9218										
PRAM1	84106	broad.mit.edu	37	chr19	8555562	8555562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ctccccgcgccggatcccgaGgtgcttgccacccccgcgac	11	21	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:8555562G>A	ENST00000423345.4	-	7	2342	c.1822C>T	c.(1822-1824)Ctc>Ttc	p.L608F	PRAM1_ENST00000255612.3_Missense_Mutation_p.L607F			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	656							lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						CGGATCCCGAGGTGCTTGCCA	0.617													3	21					0	0	1	0	0	A	8555562	G	A	8555562	3	1	52	1	0	0	0	0	1	0	0	0	12471	1000	35	3	206	3	PRAM1	19	8555562	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	812492	8555562	50573421	96	9219										
FCHO1	23149	broad.mit.edu	37	chr19	17899082	17899082	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	acccctccccctcacagctgCacccccacagggatgtacct	6	21	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:17899082C>T	ENST00000594202.1	+	29	2930	c.2651C>T	c.(2650-2652)gCa>gTa	p.A884V	FCHO1_ENST00000596951.1_Intron|FCHO1_ENST00000597512.1_Intron|FCHO1_ENST00000252771.7_Intron|FCHO1_ENST00000539407.1_Intron|FCHO1_ENST00000595033.1_Intron|FCHO1_ENST00000600676.1_Intron|FCHO1_ENST00000389133.4_Intron|FCHO1_ENST00000596536.1_Intron	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	0										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CTCACAGCTGCACCCCCACAG	0.647													13	12					0	0	1	0	0	T	17899082	C	T	17899082	3	4	52	1	0	0	0	0	1	0	0	0	5819	710	25	3	2753	3	FCHO1	19	17899082	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	9343520	17899082	41229901	97	9220										
ZNF780A	284323	broad.mit.edu	37	chr19	40581487	40581487	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ctgaataaggtgtgcaccacGattaaagcctttcccacact	7	12	0	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:40581487G>A	ENST00000450241.2	-	6	1071	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000594395.1_Missense_Mutation_p.R289C|ZNF780A_ENST00000340963.5_Missense_Mutation_p.R288C|ZNF780A_ENST00000455521.1_Missense_Mutation_p.R289C|ZNF780A_ENST00000595687.2_Missense_Mutation_p.R288C|AC005614.5_ENST00000595508.1_RNA			O75290	Z780A_HUMAN	zinc finger protein 780A	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R254C(1)|p.R289C(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGTGCACCACGATTAAAGCCT	0.388													78	128					0	0	1	0	0	A	40581487	G	A	40581487	3	1	52	1	0	0	0	0	1	0	0	0	18200	1058	37	1	1194	1	ZNF780A	19	40581487	Missense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	22682405	40581487	18547496	98	9221										
LTBP4	8425	broad.mit.edu	37	chr19	41111336	41111336	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gcatctatggtgagcgtccaCgtggagcacccgcaggaggc	15	12	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:41111336C>G	ENST00000308370.7	+	6	669	c.669C>G	c.(667-669)caC>caG	p.H223Q	LTBP4_ENST00000204005.9_Missense_Mutation_p.H186Q|LTBP4_ENST00000545697.1_5'UTR|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000396819.3_Missense_Mutation_p.H156Q	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	223					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAGCGTCCACGTGGAGCACC	0.692													13	51					0	0	1	0	0	G	41111336	C	G	41111336	3	3	52	1	0	0	0	0	1	0	0	0	9120	535	19	5	984	5	LTBP4	19	41111336	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	529849	41111336	18017647	99	9222										
DMPK	1760	broad.mit.edu	37	chr19	46274875	46274875	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	atccgctcctgcaactgccgGacgtgtgcctctaggtcccg	11	16	1	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:46274875G>A	ENST00000600757.1	-	11	2253	c.1566C>T	c.(1564-1566)gtC>gtT	p.V522V	AC074212.6_ENST00000586251.1_RNA|DMPK_ENST00000458663.2_Silent_p.V512V|DMPK_ENST00000447742.2_Silent_p.V512V|DMPK_ENST00000343373.4_Silent_p.V527V|DMPK_ENST00000291270.4_Silent_p.V517V|AC074212.6_ENST00000586498.1_RNA|DMPK_ENST00000354227.5_Silent_p.V512V|AC074212.6_ENST00000591530.1_RNA|AC074212.6_ENST00000590076.1_RNA			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	527					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		GCAACTGCCGGACGTGTGCCT	0.672													18	51					0	0	1	0	0	A	46274875	G	A	46274875	2	1	52	1	0	0	0	0	0	0	0	1	4612	1161	41	3		3	DMPK	19	46274875	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	5163539	46274875	12854108	100	9223										
SYMPK	8189	broad.mit.edu	37	chr19	46320139	46320139	+	Frame_Shift_Del	DEL	G	G	-													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aaagacggctcccagctgctGgggcggcagctgcaggatga							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:46320139delG	ENST00000245934.7	-	24	3419	c.3175delC	c.(3175-3177)agfs	p.Q1060fs	SYMPK_ENST00000598155.1_5'UTR	NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	1060					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CCCAGCTGCTGGGGCGGCAGC	0.652											OREG0025562	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---						-	46320139	G	-	46320139	7	5	52	1	0	1	0	1	0	0	0	0	15495	1357	47	0	665	0	SYMPK	19	46320139	Frame_Shift_Del	DEL	G	TCGA-NF-A4X2-01A-11D-A28R-08	45264	46320139	12808844	101	9224										
NTN5	126147	broad.mit.edu	37	chr19	49174007	49174007	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cctggggtacagaagcgcaaGctgacagatgtcaggaggaa	15	8	1	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:49174007G>A	ENST00000270235.4	-	2	332	c.237C>T	c.(235-237)agC>agT	p.S79S	SEC1P_ENST00000430145.2_RNA	NM_145807.1	NP_665806.1	Q8WTR8	NET5_HUMAN	netrin 5	79						extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	10						AGAAGCGCAAGCTGACAGATG	0.667													33	20					0	0	1	0	0	A	49174007	G	A	49174007	2	1	52	1	0	0	0	0	0	0	0	1	10750	962	34	3		3	NTN5	19	49174007	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	2853868	49174007	9954976	102	9225										
PLEKHA4	0	broad.mit.edu	37	chr19	49362194	49362200	+	Frame_Shift_Del	DEL	GGCGGGG	GGCGGGG	-													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agcctcagagggaggtcctcGgcggggagtagggggtcggg							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:49362194_49362200delGGCGGGG	ENST00000263265.6	-	8	1444_1450	c.889_895delCCCCGCC	c.(889-897)gafs	p.PRR297fs	PLEKHA4_ENST00000355496.5_Frame_Shift_Del_p.PRR297fs|PLEKHA4_ENST00000596713.1_5'UTR	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	297	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GGAGGTCCTCGGCGGGGAGTAGGGGGT	0.662													29	103	---	---	---	---						-	49362200	GGCGGGG	-	49362194	7	5	52	1	0	1	0	1	0	0	0	0	12105	1124	39	0	1496	0	PLEKHA4	19	49362194	Frame_Shift_Del	DEL	GGCGGGG	TCGA-NF-A4X2-01A-11D-A28R-08	188187	49362194	9766789	103	9226										
PPP2R1A	5518	broad.mit.edu	37	chr19	52715982	52715982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	atgacacccccatggtgcggCgggccgcagcctccaagctg	13	16	0	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:52715982C>T	ENST00000322088.6	+	5	605	c.547C>T	c.(547-549)Cgg>Tgg	p.R183W	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.R128W|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.R4W	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	183	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183W(22)|p.R183G(2)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CATGGTGCGGCGGGCCGCAGC	0.617			Mis		clear cell ovarian carcinoma								59	41					0	0	1	0	0	T	52715982	C	T	52715982	3	4	52	1	0	0	0	0	1	0	0	0	12430	759	27	1	565	1	PPP2R1A	19	52715982	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	3353788	52715982	6413001	104	9227										
ZNF749	388567	broad.mit.edu	37	chr19	57956698	57956698	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aaagtccttttaagttaaggGaatgtgggaaagacttcaac	10	5	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr19:57956698G>T	ENST00000334181.4	+	3	2432	c.2182G>T	c.(2182-2184)Gaa>Taa	p.E728*	AC004076.9_ENST00000596831.1_Intron	NM_001023561.2	NP_001018855.2	O43361	ZN749_HUMAN	zinc finger protein 749	728					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|lung(3)|prostate(1)	13		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TAAGTTAAGGGAATGTGGGAA	0.403													23	62					2.39556e-15	2.85857e-15	1	1	0	T	57956698	G	T	57956698	4	4	52	1	0	0	0	0	0	1	0	0	18180	1175	41	2	2192	2	ZNF749	19	57956698	Nonsense_Mutation	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	5240716	57956698	1172285	105	9228										
ESF1	51575	broad.mit.edu	37	chr20	13695536	13695537	+	Frame_Shift_Ins	INS	-	-	T													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ccagttatttgactttttgcINSttttttcttgcttgaaactg							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr20:13695536_13695537insT	ENST00000202816.1	-	14	2647_2648	c.2540_2541insA	c.(2539-2541)acafs	p.T847fs		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	847	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TGACTTTTTGCTTTTTTCTTGC	0.302													24	13	---	---	---	---						T	13695537	-	T	13695536	7	5	52	1	0	1	1	0	0	0	0	0	5279	796	28	0	18	0	ESF1	20	13695536	Frame_Shift_Ins	INS	-	TCGA-NF-A4X2-01A-11D-A28R-08		13695536	49329984	106	9229										
PROCR	10544	broad.mit.edu	37	chr20	33764024	33764024	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agctgcctcccgagggctctAgagcccatgtcttcttcgaa	10	14	3	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr20:33764024A>G	ENST00000216968.4	+	3	458	c.376A>G	c.(376-378)Aga>Gga	p.R126G	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	126					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CGAGGGCTCTAGAGCCCATGT	0.607													33	98					0	0	1	0	0	G	33764024	A	G	33764024	3	3	52	1	0	0	0	0	1	0	0	0	12598	412	15	4	386	4	PROCR	20	33764024	Missense_Mutation	SNP	A	TCGA-NF-A4X2-01A-11D-A28R-08	20068488	33764024	29261496	107	9230										
BAGE2	85319	broad.mit.edu	37	chr21	11073982	11073982	+	RNA	DEL	T	T	-													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	ttataaactgaaataactgcTtttttcatggaacactgttt					rs58848388		TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr21:11073982delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aaataactgcttttttcatgg	0.274													2	4	---	---	---	---						-	11073982	T	-	11073982	6	5	52	0	1	1	0	1	0	0	0	0	1290	1624	56	0		0	BAGE2	21	11073982	RNA	DEL	T	TCGA-NF-A4X2-01A-11D-A28R-08		11073982	37055913	108	9231										
MED15	51586	broad.mit.edu	37	chr22	20918793	20918795	+	In_Frame_Del	DEL	CAG	CAG	-													0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agcagcaacagcagcagttcCagcagcagcagcaggcggcg							TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr22:20918793_20918795delCAG	ENST00000263205.7	+	6	577_579	c.508_510delCAG	c.(508-510)del	p.Q174del	MED15_ENST00000542773.1_5'UTR|MED15_ENST00000425759.2_In_Frame_Del_p.Q63del|MED15_ENST00000406969.1_In_Frame_Del_p.Q148del|MED15_ENST00000292733.7_In_Frame_Del_p.Q174del|MED15_ENST00000382974.2_In_Frame_Del_p.Q103del|MED15_ENST00000541476.1_In_Frame_Del_p.Q148del	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	174	Poly-Gln.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			gcagcagttccagcagcagcagc	0.616											OREG0026319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	98	---	---	---	---						-	20918795	CAG	-	20918793	7	5	52	1	0	1	0	1	0	0	0	0	9482	595	21	0	530	0	MED15	22	20918793	In_Frame_Del	DEL	CAG	TCGA-NF-A4X2-01A-11D-A28R-08		20918793	30385773	109	9232										
TNRC6B	23112	broad.mit.edu	37	chr22	40711382	40711382	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tgtggaaaaaccatatttccTccaggaacactacaccgctg	7	12	0	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chr22:40711382T>C	ENST00000454349.2	+	20	4985	c.4774T>C	c.(4774-4776)Tcc>Ccc	p.S1592P	TNRC6B_ENST00000335727.8_Missense_Mutation_p.S1482P|TNRC6B_ENST00000301923.9_Missense_Mutation_p.S788P|TNRC6B_ENST00000402203.1_Missense_Mutation_p.S788P	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1592					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CCATATTTCCTCCAGGAACAC	0.537													7	70					0	0	1	0	0	C	40711382	T	C	40711382	3	2	52	1	0	0	0	0	1	0	0	0	16400	1551	54	4	4973	4	TNRC6B	22	40711382	Missense_Mutation	SNP	T	TCGA-NF-A4X2-01A-11D-A28R-08	19792589	40711382	10593184	110	9233										
VCX	26609	broad.mit.edu	37	chrX	7811258	7811258	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	gcggaagatgagtccaaagcCgagagcctcgggacctccgg	15	12	0	3			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:7811258C>T	ENST00000381059.3	+	2	233	c.14C>T	c.(13-15)cCg>cTg	p.P5L	VCX_ENST00000341408.4_Missense_Mutation_p.P5L	NM_013452.2	NP_038480.2	Q9H320	VCX1_HUMAN	variable charge, X-linked	5					chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding			NS(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	10		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				AGTCCAAAGCCGAGAGCCTCG	0.622													30	221					0	0	1	0	0	T	7811258	C	T	7811258	3	4	52	1	0	0	0	0	1	0	0	0	17201	652	23	1	16	1	VCX	23	7811258	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08		7811258	147459302	111	9234										
MAGEB6	158809	broad.mit.edu	37	chrX	26212812	26212812	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	agtggtgataatgcgctgccGaagtcgggtctcctgatgtc	14	9	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:26212812G>A	ENST00000379034.1	+	2	998	c.849G>A	c.(847-849)ccG>ccA	p.P283P		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	283	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						ATGCGCTGCCGAAGTCGGGTC	0.527													30	271					0	0	1	0	0	A	26212812	G	A	26212812	2	1	52	1	0	0	0	0	0	0	0	1	9228	1045	37	1		1	MAGEB6	23	26212812	Silent	SNP	G	TCGA-NF-A4X2-01A-11D-A28R-08	18401554	26212812	129057748	112	9235										
HDAC6	10013	broad.mit.edu	37	chrX	48673986	48673986	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tctccctgccctgcagtgccCaggcttcagtttcctgtgct	9	16	2	0			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:48673986C>A	ENST00000334136.5	+	16	1439	c.1261C>A	c.(1261-1263)Cag>Aag	p.Q421K	HDAC6_ENST00000376619.2_Missense_Mutation_p.Q421K|HDAC6_ENST00000444343.2_Missense_Mutation_p.Q435K			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	421					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	CTGCAGTGCCCAGGCTTCAGT	0.617													23	88					2.89027e-11	3.30982e-11	1	1	0	A	48673986	C	A	48673986	3	1	52	1	0	0	0	0	1	0	0	0	7051	595	21	5	1319	5	HDAC6	23	48673986	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	22461174	48673986	106596574	113	9236										
PPP1R3F	89801	broad.mit.edu	37	chrX	49142813	49142813	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	cgccctggctgaggagatcaCgctgcactatgcccggctgg	14	14	1	2			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:49142813C>T	ENST00000055335.6	+	4	1677	c.1661C>T	c.(1660-1662)aCg>aTg	p.T554M	PPP1R3F_ENST00000438316.1_Missense_Mutation_p.T225M|PPP1R3F_ENST00000376188.1_Missense_Mutation_p.T208M|PPP1R3F_ENST00000495799.1_Missense_Mutation_p.T208M|PPP1R3F_ENST00000466508.1_Missense_Mutation_p.T208M	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F	554						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					GAGGAGATCACGCTGCACTAT	0.647													38	15					0	0	1	0	0	T	49142813	C	T	49142813	3	4	52	1	0	0	0	0	1	0	0	0	12423	536	19	1	1675	1	PPP1R3F	23	49142813	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	468827	49142813	106127747	114	9237										
RGAG4	340526	broad.mit.edu	37	chrX	71350291	71350291	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	tcatctcttgctgaaaagccCtcatgcgcttcctctggtcc	7	15	4	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:71350291C>A	ENST00000545866.1	-	1	1467	c.1100G>T	c.(1099-1101)aGg>aTg	p.R367M	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.R367M			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	367										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					CTGAAAAGCCCTCATGCGCTT	0.488													7	21					0.0293803	0.0300144	1	1	0	A	71350291	C	A	71350291	3	1	52	1	0	0	0	0	1	0	0	0	13326	681	24	5	613	5	RGAG4	23	71350291	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	22207478	71350291	83920269	115	9238										
SRPX2	27286	broad.mit.edu	37	chrX	99917215	99917215	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aaatatccaggatggagaagCcacatgctactcaccgaagg	10	10	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:99917215C>T	ENST00000373004.3	+	4	634	c.206C>T	c.(205-207)gCc>gTc	p.A69V		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	69	Sushi 1.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						GATGGAGAAGCCACATGCTAC	0.488													13	123					0	0	1	0	0	T	99917215	C	T	99917215	3	4	52	1	0	0	0	0	1	0	0	0	15220	739	26	3	216	3	SRPX2	23	99917215	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	28566924	99917215	55353345	116	9239										
TEX13B	0	broad.mit.edu	37	chrX	107225158	107225158	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0341880341880342	4	1	0.615223097112861	1.23044619422572	0.410148731408574	1	1	0	aggccaggctgccccaggtgCaggcctctttgacctcgctg	13	15	1	1			TCGA-NF-A4X2-01A-11D-A28R-08	TCGA-NF-A4X2-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e231bc3f-bb82-4de8-8003-6d37dc799332	cfbc4df1-a359-4e3b-bb47-af77647ca523	g.chrX:107225158C>A	ENST00000302917.1	-	2	292	c.200G>T	c.(199-201)tGc>tTc	p.C67F		NM_031273.2	NP_112563.1	Q9BXU2	TX13B_HUMAN	testis expressed 13B	67										breast(1)|endometrium(5)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28						GCCCCAGGTGCAGGCCTCTTT	0.592													165	18					9.28845e-81	1.21005e-80	1	1	0	A	107225158	C	A	107225158	3	1	52	1	0	0	0	0	1	0	0	0	15835	710	25	5	746	5	TEX13B	23	107225158	Missense_Mutation	SNP	C	TCGA-NF-A4X2-01A-11D-A28R-08	7307943	107225158	48045402	117	9240										
ARID1A	8289	broad.mit.edu	37	chr1	27057848	27057848	+	Frame_Shift_Del	DEL	C	C	-													0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtcctctcagcctccatactCccagcagccatcccagcctc							TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr1:27057848delC	ENST00000324856.7	+	3	1927	c.1556delC	c.(1555-1557)tcfs	p.S519fs	ARID1A_ENST00000374152.2_Frame_Shift_Del_p.S136fs|ARID1A_ENST00000457599.2_Frame_Shift_Del_p.S519fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	519					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTCCATACTCCCAGCAGCCA	0.632			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								152	284	---	---	---	---						-	27057848	C	-	27057848	7	5	53	1	0	1	0	1	0	0	0	0	910	855	30	0	1566	0	ARID1A	1	27057848	Frame_Shift_Del	DEL	C	TCGA-NF-A5CP-01A-12D-A28R-08		27057848	222192773	1	9241										
ARID1A	8289	broad.mit.edu	37	chr1	27106527	27106528	+	Frame_Shift_Ins	INS	-	-	GAGT													0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gggtgagctgcaacaaagtgINSgagtggtggtgggactgctt							TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr1:27106527_27106528insGAGT	ENST00000324856.7	+	20	6509_6510	c.6138_6139insGAGT	c.(6136-6141)gtagtgfs	p.V2047fs	ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.V1664fs|ARID1A_ENST00000540690.1_Frame_Shift_Ins_p.V375fs|ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.V1830fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2047					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.E2047*(3)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAACAAAGTGGAGTGGTGGTG	0.55			"Mis, N, F, S, D"		"clear cell ovarian carcinoma, RCC"								41	84	---	---	---	---						GAGT	27106528	-	GAGT	27106527	7	5	53	1	0	1	1	0	0	0	0	0	910	1335	47	0	6216	0	ARID1A	1	27106527	Frame_Shift_Ins	INS	-	TCGA-NF-A5CP-01A-12D-A28R-08	48679	27106527	222144094	2	9242										
DENND2C	163259	broad.mit.edu	37	chr1	115143531	115143531	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	atgacacttcgcatgaatggGtaaacaagggctggagacat	12	7	0	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr1:115143531G>A	ENST00000393274.1	-	14	2491	c.1866C>T	c.(1864-1866)taC>taT	p.Y622Y	DENND2C_ENST00000393277.1_Silent_p.Y622Y|DENND2C_ENST00000393276.3_Silent_p.Y565Y|DENND2C_ENST00000481894.1_5'UTR	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	622	DENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCATGAATGGGTAAACAAGGG	0.418													24	43					0	0	1	0	0	A	115143531	G	A	115143531	2	1	53	1	0	0	0	0	0	0	0	1	4458	1256	44	3		3	DENND2C	1	115143531	Silent	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	88037004	115143531	134107090	3	9243										
NTRK1	4914	broad.mit.edu	37	chr1	156841545	156841545	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ctctgttcaggtcaacgtctCctgtgagtctcagtggcagc	11	12	5	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr1:156841545C>A	ENST00000368196.3	+	7	968	c.848C>A	c.(847-849)tCc>tAc	p.S283Y	NTRK1_ENST00000392302.2_Missense_Mutation_p.S253Y|NTRK1_ENST00000524377.1_Missense_Mutation_p.S283Y|NTRK1_ENST00000358660.3_Missense_Mutation_p.S283Y	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	283	Ig-like C2-type 1.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GTCAACGTCTCCTGTGAGTCT	0.582			T	"TPM3, TPR, TFG"	papillary thyroid					TSP Lung(10;0.080)			9	72					3.07112e-06	3.24967e-06	1	1	0	A	156841545	C	A	156841545	3	1	53	1	0	0	0	0	1	0	0	0	10753	855	30	2	1004	2	NTRK1	1	156841545	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	41698014	156841545	92409076	4	9244										
LYST	1130	broad.mit.edu	37	chr1	235969411	235969411	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	atctccctccttttttccttGctcctctttgtgacttctga	4	14	3	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr1:235969411G>C	ENST00000389794.3	-	6	3199	c.3025C>G	c.(3025-3027)Caa>Gaa	p.Q1009E	LYST_ENST00000536965.1_Missense_Mutation_p.Q1009E|LYST_ENST00000389793.2_Missense_Mutation_p.Q1009E			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1009					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTTTTCCTTGCTCCTCTTTG	0.348													36	50					0	0	1	0	0	C	235969411	G	C	235969411	3	2	53	1	0	0	0	0	1	0	0	0	9173	1328	46	5	8572	5	LYST	1	235969411	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	79127866	235969411	13281210	5	9245										
OR2B11	127623	broad.mit.edu	37	chr1	247614475	247614475	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aatttgccctgctcttgggaGtagctggaagggggctgcag	16	8	1	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr1:247614475G>A	ENST00000318749.6	-	1	833	c.810C>T	c.(808-810)taC>taT	p.Y270Y		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCTCTTGGGAGTAGCTGGAAG	0.493													15	176					0	0	1	0	0	A	247614475	G	A	247614475	2	1	53	1	0	0	0	0	0	0	0	1	11035	1024	36	3		3	OR2B11	1	247614475	Silent	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	11645064	247614475	1636146	6	9246										
FAM161A	84140	broad.mit.edu	37	chr2	62067002	62067002	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	agctgtgtcctaaggtttcgAtagagctcttcttcttttaa	8	8	3	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:62067002A>G	ENST00000404929.1	-	3	1148	c.1137T>C	c.(1135-1137)taT>taC	p.Y379Y	FAM161A_ENST00000405894.3_Silent_p.Y379Y	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	379					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TAAGGTTTCGATAGAGCTCTT	0.433													51	42					0	0	1	0	0	G	62067002	A	G	62067002	2	3	53	1	0	0	0	0	0	0	0	1	5502	340	12	4		4	FAM161A	2	62067002	Silent	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08		62067002	181132371	7	9247										
UGGT1	56886	broad.mit.edu	37	chr2	128938646	128938646	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ctgtttgtggatgctgatcaGgtaggcccttaaaggccaag	13	8	1	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:128938646G>C	ENST00000375990.3	+	36	4414	c.4011_splice	c.e36+1	p.Q1337_splice	UGGT1_ENST00000259253.6_Splice_Site_p.Q1361_splice			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1361	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ATGCTGATCAGGTAGGCCCTT	0.378													29	43					0	0	1	0	0	C	128938646	G	C	128938646	5	2	53	1	0	0	0	0	0	0	1	0	17000	1014	35	5	4225	5	UGGT1	2	128938646	Splice_Site	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	66871644	128938646	114260727	8	9248										
FIGN	55137	broad.mit.edu	37	chr2	164467497	164467497	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tggtggggggtaggggggtgGgagcaggaattcctgaaggc	23	4	0	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:164467497G>T	ENST00000333129.3	-	3	1159	c.845C>A	c.(844-846)cCc>cAc	p.P282H	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	282	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						TAGGGGGGTGGGAGCAGGAAT	0.602													32	38					2.80507e-11	3.07544e-11	1	1	0	T	164467497	G	T	164467497	3	4	53	1	0	0	0	0	1	0	0	0	5923	1232	43	5	1438	5	FIGN	2	164467497	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	35528851	164467497	78731876	9	9249										
LRP2	4036	broad.mit.edu	37	chr2	169995843	169995843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aattgccagagctccaattaCgacgatcaagaggattgtca	9	9	2	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:169995843C>T	ENST00000263816.3	-	74	13591	c.13306G>A	c.(13306-13308)Gta>Ata	p.V4436I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4436					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCTCCAATTACGACGATCAAG	0.507													6	73					0	0	1	0	0	T	169995843	C	T	169995843	3	4	53	1	0	0	0	0	1	0	0	0	9000	536	19	1	685	1	LRP2	2	169995843	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	5528346	169995843	73203530	10	9250										
ABCA12	26154	broad.mit.edu	37	chr2	215815735	215815735	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ccactctcaactcttaatctCtcagcccgcacatcttcatc	2	18	6	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:215815735C>G	ENST00000272895.7	-	45	6939	c.6720G>C	c.(6718-6720)gaG>gaC	p.E2240D	AC072062.1_ENST00000607412.1_RNA|ABCA12_ENST00000389661.4_Missense_Mutation_p.E1922D	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2240					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTCTTAATCTCTCAGCCCGCA	0.383													81	93					0	0	1	0	0	G	215815735	C	G	215815735	3	3	53	1	0	0	0	0	1	0	0	0	30	912	32	2	1103	2	ABCA12	2	215815735	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	45819892	215815735	27383638	11	9251										
OBSL1	23363	broad.mit.edu	37	chr2	220421348	220421348	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ttgcgcagccaggtgacatcGgcatctggtggggagacttc	15	10	1	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:220421348G>A	ENST00000404537.1	-	13	4220	c.4164C>T	c.(4162-4164)gcC>gcT	p.A1388A	OBSL1_ENST00000265317.5_Silent_p.A287A|OBSL1_ENST00000373876.1_Silent_p.A1296A|OBSL1_ENST00000265318.4_Silent_p.A1296A|OBSL1_ENST00000603926.1_Silent_p.A1388A	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	1388	Ig-like 12.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		AGGTGACATCGGCATCTGGTG	0.617													24	56					0	0	1	0	0	A	220421348	G	A	220421348	2	1	53	1	0	0	0	0	0	0	0	1	10860	1103	39	1		1	OBSL1	2	220421348	Silent	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	4605613	220421348	22778025	12	9252										
MRPL44	65080	broad.mit.edu	37	chr2	224831613	224831613	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	attgcagaaggacctggggaAacagtattggttgcagaaga	14	5	0	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr2:224831613A>G	ENST00000258383.3	+	4	930	c.861A>G	c.(859-861)gaA>gaG	p.E287E	AC073641.2_ENST00000425192.1_RNA	NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	287	DRBM.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		GACCTGGGGAAACAGTATTGG	0.403													40	105					0	0	1	0	0	G	224831613	A	G	224831613	2	3	53	1	0	0	0	0	0	0	0	1	9856	11	1	4		4	MRPL44	2	224831613	Silent	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08	4410265	224831613	18367760	13	9253										
PTPN23	25930	broad.mit.edu	37	chr3	47451557	47451557	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ctgacatggtggctggcccaCgactgcctgacaccttcctg	11	15	0	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr3:47451557C>T	ENST00000265562.4	+	20	2346	c.2269C>T	c.(2269-2271)Cga>Tga	p.R757*	PTPN23_ENST00000431726.1_Nonsense_Mutation_p.R631*	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	757	Pro-rich.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGCTGGCCCACGACTGCCTGA	0.677													3	14					0	0	1	0	0	T	47451557	C	T	47451557	4	4	53	1	0	0	0	0	0	1	0	0	12839	528	19	1	2347	1	PTPN23	3	47451557	Nonsense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		47451557	150570873	14	9254										
ARHGAP31	57514	broad.mit.edu	37	chr3	119013766	119013766	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	taactcatgaagaacaagggTgctaagcagaagctgaaacg	11	7	1	4			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr3:119013766T>A	ENST00000264245.4	+	1	547	c.15T>A	c.(13-15)ggT>ggA	p.G5G		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	5					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						AGAACAAGGGTGCTAAGCAGA	0.587													9	80					0	0	1	0	0	A	119013766	T	A	119013766	2	1	53	1	0	0	0	0	0	0	0	1	877	1683	59	4		4	ARHGAP31	3	119013766	Silent	SNP	T	TCGA-NF-A5CP-01A-12D-A28R-08	71562209	119013766	79008664	15	9255										
PLSCR2	57047	broad.mit.edu	37	chr3	146177862	146177862	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cttagggtagacaatatgtcCgggaggtcctgaaataggag	14	6	0	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr3:146177862C>T	ENST00000497985.1	-	4	488	c.49G>A	c.(49-51)Gga>Aga	p.G17R	PLSCR2_ENST00000336685.2_5'UTR	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	0					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						ACAATATGTCCGGGAGGTCCT	0.483													3	4					0	0	1	0	0	T	146177862	C	T	146177862	3	4	53	1	0	0	0	0	1	0	0	0	12157	667	23	1		1	PLSCR2	3	146177862	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	27164096	146177862	51844568	16	9256										
PIK3CA	5290	broad.mit.edu	37	chr3	178916936	178916936	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aattgaaccagtaggcaaccGtgaagaaaagatcctcaatc	8	9	1	4			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr3:178916936G>A	ENST00000263967.3	+	2	480	c.323G>A	c.(322-324)cGt>cAt	p.R108H		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	108	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R108H(11)|p.R108L(2)|p.G106_R108delGNR(2)|p.G106_R108del(2)|p.R108P(1)|p.R108del(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTAGGCAACCGTGAAGAAAAG	0.338		57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			58	37					0	0	1	0	0	A	178916936	G	A	178916936	3	1	53	1	0	0	0	0	1	0	0	0	11960	1145	40	1	325	1	PIK3CA	3	178916936	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	32739074	178916936	19105494	17	9257										
SEC31A	22872	broad.mit.edu	37	chr4	83793139	83793139	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gaagtggagaggaagcaaatCgaagatcccacatctggatc	12	8	1	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr4:83793139C>A	ENST00000432794.1	-	7	903	c.740G>T	c.(739-741)cGa>cTa	p.R247L	SEC31A_ENST00000311785.7_Missense_Mutation_p.R247L|SEC31A_ENST00000443462.2_Missense_Mutation_p.R242L|SEC31A_ENST00000508479.1_Missense_Mutation_p.R247L|SEC31A_ENST00000513858.1_Missense_Mutation_p.R247L|SEC31A_ENST00000509142.1_Missense_Mutation_p.R247L|SEC31A_ENST00000508502.1_Missense_Mutation_p.R247L|SEC31A_ENST00000505984.1_Missense_Mutation_p.R247L|SEC31A_ENST00000395310.2_Missense_Mutation_p.R247L|SEC31A_ENST00000505472.1_Missense_Mutation_p.R247L|SEC31A_ENST00000500777.2_Missense_Mutation_p.R247L|SEC31A_ENST00000448323.1_Missense_Mutation_p.R247L|SEC31A_ENST00000355196.2_Missense_Mutation_p.R247L|SEC31A_ENST00000348405.4_Missense_Mutation_p.R247L|SEC31A_ENST00000326950.5_Missense_Mutation_p.R247L|SEC31A_ENST00000436790.2_5'UTR			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	247	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				GGAAGCAAATCGAAGATCCCA	0.473													44	14					1.32136e-16	1.46638e-16	1	1	0	A	83793139	C	A	83793139	3	1	53	1	0	0	0	0	1	0	0	0	14051	884	31	2	3006	2	SEC31A	4	83793139	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		83793139	107361137	18	9258										
DMP1	1758	broad.mit.edu	37	chr4	88584263	88584263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gctcagcagagagtcagagcGaggaaagccattctgaggaa	14	8	3	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr4:88584263G>A	ENST00000339673.6	+	6	1432	c.1333G>A	c.(1333-1335)Gag>Aag	p.E445K	RP11-742B18.1_ENST00000506480.1_RNA|RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.E429K	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	445					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GAGTCAGAGCGAGGAAAGCCA	0.542													70	17					0	0	1	0	0	A	88584263	G	A	88584263	3	1	53	1	0	0	0	0	1	0	0	0	4611	1059	37	1	1351	1	DMP1	4	88584263	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	4791124	88584263	102570013	19	9259										
DSP	1832	broad.mit.edu	37	chr6	7580595	7580595	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ggaagaggataccagtggctAccgggctcagatagacaatc	13	9	1	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:7580595A>G	ENST00000379802.3	+	23	4513	c.4172A>G	c.(4171-4173)tAc>tGc	p.Y1391C	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1391	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACCAGTGGCTACCGGGCTCAG	0.463													46	79					0	0	1	0	0	G	7580595	A	G	7580595	3	3	53	1	0	0	0	0	1	0	0	0	4807	391	14	4	4262	4	DSP	6	7580595	Missense_Mutation	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08		7580595	163534472	20	9260										
ZFP57	346171	broad.mit.edu	37	chr6	29641083	29641083	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tttgagctcagactggtcccGgaagctcttcccacacacag	9	14	2	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:29641083G>A	ENST00000376883.1	-	6	1156	c.745C>T	c.(745-747)Cgg>Tgg	p.R249W	ZFP57_ENST00000376881.3_Missense_Mutation_p.R249W|ZFP57_ENST00000488757.1_Missense_Mutation_p.R269W			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	185					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						GACTGGTCCCGGAAGCTCTTC	0.557													40	83					0	0	1	0	0	A	29641083	G	A	29641083	3	1	53	1	0	0	0	0	1	0	0	0	17708	1115	39	1	809	1	ZFP57	6	29641083	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	22060488	29641083	141473984	21	9261										
C2	717	broad.mit.edu	37	chr6	31913052	31913052	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tagcaaggtcccgccgccacGagactttcacatcaatctct	7	15	3	1	rs147553278		TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:31913052G>C	ENST00000299367.5	+	18	2453	c.2177G>C	c.(2176-2178)cGa>cCa	p.R726P	CFB_ENST00000556679.1_Intron|C2_ENST00000442278.2_Missense_Mutation_p.R594P|CFB_ENST00000456570.1_Intron|C2_ENST00000468407.1_Intron|C2_ENST00000452323.2_Missense_Mutation_p.R512P|CFB_ENST00000477310.1_Intron|C2_ENST00000469372.1_Missense_Mutation_p.R480P	NM_000063.4	NP_000054.2			complement component 2											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	27		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		CCGCCGCCACGAGACTTTCAC	0.587													26	61					0	0	1	0	0	C	31913052	G	C	31913052	3	2	53	1	0	0	0	0	1	0	0	0	2088	1058	37	2	2324	2	C2	6	31913052	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	2271969	31913052	139202015	22	9262										
HLA-DQA1	3117	broad.mit.edu	37	chr6	32609250	32609250	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aaatttggaggttttgacccGcagggtgcactgagaaacat	12	7	0	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:32609250G>A	ENST00000343139.5	+	2	348	c.246G>A	c.(244-246)ccG>ccA	p.P82P	HLA-DQA1_ENST00000395363.1_Silent_p.P82P|HLA-DQA1_ENST00000374949.2_Silent_p.P82P	NM_002122.3	NP_002113.2	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ alpha 1	81	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						GTTTTGACCCGCAGGGTGCAC	0.502													20	13					0	0	1	0	0	A	32609250	G	A	32609250	2	1	53	1	0	0	0	0	0	0	0	1	7244	1074	38	1		1	HLA-DQA1	6	32609250	Silent	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	696198	32609250	138505817	23	9263										
PHF1	5252	broad.mit.edu	37	chr6	33383699	33383699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	catccccaggtcttcctagaCgctcagcacccccttctccc	5	21	3	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:33383699C>T	ENST00000374516.3	+	15	1799	c.1528C>T	c.(1528-1530)Cgc>Tgc	p.R510C	PHF1_ENST00000374512.3_3'UTR	NM_024165.2	NP_077084.1	O43189	PHF1_HUMAN	PHD finger protein 1	510					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19		Ovarian(999;0.0443)				TCTTCCTAGACGCTCAGCACC	0.592													48	92					0	0	1	0	0	T	33383699	C	T	33383699	3	4	53	1	0	0	0	0	1	0	0	0	11867	536	19	1	1582	1	PHF1	6	33383699	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	774449	33383699	137731368	24	9264										
GPR63	0	broad.mit.edu	37	chr6	97246772	97246772	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tgaggcatataccttcagggTagctatggatcctcaaggca	11	9	2	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:97246772T>A	ENST00000229955.3	-	2	1181	c.836A>T	c.(835-837)tAc>tTc	p.Y279F	GPR63_ENST00000417980.1_Missense_Mutation_p.Y279F	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	279						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		ACCTTCAGGGTAGCTATGGAT	0.468													19	64					0	0	1	0	0	A	97246772	T	A	97246772	3	1	53	1	0	0	0	0	1	0	0	0	6743	1638	57	4	427	4	GPR63	6	97246772	Missense_Mutation	SNP	T	TCGA-NF-A5CP-01A-12D-A28R-08	63863073	97246772	73868295	25	9265										
SLC22A3	6581	broad.mit.edu	37	chr6	160858039	160858039	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gttgctacaggttcacaagcGcagtggtgtatcaaggactt	12	8	2	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr6:160858039G>A	ENST00000392145.1	+	7	1111	c.1084G>A	c.(1084-1086)Gca>Aca	p.A362T	SLC22A3_ENST00000275300.2_Missense_Mutation_p.A362T			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	362						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GTTCACAAGCGCAGTGGTGTA	0.448													10	102					0	0	1	0	0	A	160858039	G	A	160858039	3	1	53	1	0	0	0	0	1	0	0	0	14509	1087	38	1	1110	1	SLC22A3	6	160858039	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	63611267	160858039	10257028	26	9266										
GCK	2645	broad.mit.edu	37	chr7	44185169	44185169	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtcctcgctgcggctctcgcGcatgcggttgatgacgcccg	14	15	1	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr7:44185169G>A	ENST00000403799.3	-	9	1649	c.1180C>T	c.(1180-1182)Cgc>Tgc	p.R394C	GCK_ENST00000395796.3_Missense_Mutation_p.R393C|GCK_ENST00000437084.1_Missense_Mutation_p.R377C|GCK_ENST00000345378.2_Missense_Mutation_p.R395C	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	394					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CGGCTCTCGCGCATGCGGTTG	0.692													9	20					0	0	1	0	0	A	44185169	G	A	44185169	3	1	53	1	0	0	0	0	1	0	0	0	6332	1087	38	1	225	1	GCK	7	44185169	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08		44185169	114953494	27	9267										
GRM3	0	broad.mit.edu	37	chr7	86468552	86468552	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gactacatcaggtgggaagaCgcctgggccattggcccagt	14	11	1	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr7:86468552C>T	ENST00000361669.2	+	4	2821	c.1722C>T	c.(1720-1722)gaC>gaT	p.D574D	GRM3_ENST00000394720.2_Intron|GRM3_ENST00000546348.1_Silent_p.D166D|GRM3_ENST00000536043.1_Silent_p.D446D|GRM3_ENST00000439827.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	574					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGTGGGAAGACGCCTGGGCCA	0.498													36	57					0	0	1	0	0	T	86468552	C	T	86468552	2	4	53	1	0	0	0	0	0	0	0	1	6838	535	19	1		1	GRM3	7	86468552	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	42283383	86468552	72670111	28	9268										
HTR5A	3361	broad.mit.edu	37	chr7	154863078	154863078	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cgctccgcacccgcaagtgcGtctccaacgtcatgatcgcg	10	17	2	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr7:154863078G>A	ENST00000287907.2	+	1	1045	c.469G>A	c.(469-471)Gtc>Atc	p.V157I	AC093726.4_ENST00000543018.1_De_novo_Start_InFrame|AC093726.4_ENST00000493904.1_5'UTR|AC093726.4_ENST00000395731.2_De_novo_Start_InFrame	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	157						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CCGCAAGTGCGTCTCCAACGT	0.622													35	67					0	0	1	0	0	A	154863078	G	A	154863078	3	1	53	1	0	0	0	0	1	0	0	0	7493	1145	40	1	471	1	HTR5A	7	154863078	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	68394526	154863078	4275585	29	9269										
RP1L1	94137	broad.mit.edu	37	chr8	10470756	10470756	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ctgccaggagcagggcccacCggggggttgctaggaccagg	18	12	0	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr8:10470756C>T	ENST00000382483.3	-	4	1075	c.852G>A	c.(850-852)ccG>ccA	p.P284P		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	284					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CAGGGCCCACCGGGGGGTTGC	0.662													7	71					0	0	1	0	0	T	10470756	C	T	10470756	2	4	53	1	0	0	0	0	0	0	0	1	13584	639	23	1		1	RP1L1	8	10470756	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		10470756	135893266	30	9270										
VPS13B	157680	broad.mit.edu	37	chr8	100865978	100865978	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gggagaaaaagcagaacccaTtcagtgttccaaaatgcaga	10	8	1	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr8:100865978T>G	ENST00000358544.2	+	56	10547	c.10436T>G	c.(10435-10437)aTt>aGt	p.I3479S	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.I3454S	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3479					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCAGAACCCATTCAGTGTTCC	0.418													241	33					0	0	1	0	0	G	100865978	T	G	100865978	3	3	53	1	0	0	0	0	1	0	0	0	17249	1493	52	4	10848	4	VPS13B	8	100865978	Missense_Mutation	SNP	T	TCGA-NF-A5CP-01A-12D-A28R-08	90395222	100865978	45498044	31	9271										
RIMS2	9699	broad.mit.edu	37	chr8	104955062	104955062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	acattggtacaaacttcagaCgcatgatgtctcttcattgc	7	10	3	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr8:104955062C>T	ENST00000507740.1	+	11	2221	c.1985C>T	c.(1984-1986)aCg>aTg	p.T662M	RIMS2_ENST00000406091.3_Missense_Mutation_p.T870M|RIMS2_ENST00000436393.2_Missense_Mutation_p.T648M|RIMS2_ENST00000262231.10_Missense_Mutation_p.T709M	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	932					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAACTTCAGACGCATGATGTC	0.418										HNSCC(12;0.0054)			15	77					0	0	1	0	0	T	104955062	C	T	104955062	3	4	53	1	0	0	0	0	1	0	0	0	13419	536	19	1	2789	1	RIMS2	8	104955062	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	4089084	104955062	41408960	32	9272										
EFR3A	23167	broad.mit.edu	37	chr8	132980594	132980594	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tctaggacaccttgatgctcGtaaaaaagatgctccccggg	10	11	1	2	rs148528328		TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr8:132980594G>A	ENST00000254624.5	+	9	1133	c.908G>A	c.(907-909)cGt>cAt	p.R303H	EFR3A_ENST00000334503.4_Missense_Mutation_p.R303H|EFR3A_ENST00000519656.1_Missense_Mutation_p.R267H	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	303						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CTTGATGCTCGTAAAAAAGAT	0.428													18	66					0	0	1	0	0	A	132980594	G	A	132980594	3	1	53	1	0	0	0	0	1	0	0	0	4984	1145	40	1	942	1	EFR3A	8	132980594	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	28025532	132980594	13383428	33	9273										
POMT1	10585	broad.mit.edu	37	chr9	134385763	134385763	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtcttccgctctgggccccaCgaccaaatcatgtccagtgc	9	16	3	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr9:134385763C>T	ENST00000423007.1	+	9	1258	c.816C>T	c.(814-816)caC>caT	p.H272H	POMT1_ENST00000402686.3_Silent_p.H272H|POMT1_ENST00000404875.2_Silent_p.H155H|POMT1_ENST00000541219.1_Silent_p.H50H|POMT1_ENST00000354713.4_Silent_p.H242H|POMT1_ENST00000419118.2_Silent_p.H120H|POMT1_ENST00000372228.3_Silent_p.H294H|POMT1_ENST00000341012.7_Silent_p.H218H	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	294					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		CTGGGCCCCACGACCAAATCA	0.542													22	29					0	0	1	0	0	T	134385763	C	T	134385763	2	4	53	1	0	0	0	0	0	0	0	1	12292	535	19	1		1	POMT1	9	134385763	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		134385763	6827668	34	9274										
KIAA1279	26128	broad.mit.edu	37	chr10	70748846	70748846	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtggtggagcccgaggggccCgtcgcccagcgagcggtgag	20	12	0	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr10:70748846C>G	ENST00000361983.4	+	1	360	c.258C>G	c.(256-258)ccC>ccG	p.P86P		NM_015634.3	NP_056449.1	Q96EK5	KBP_HUMAN	KIAA1279	86					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	14						CCGAGGGGCCCGTCGCCCAGC	0.721													4	65					0	0	1	0	0	G	70748846	C	G	70748846	2	3	53	1	0	0	0	0	0	0	0	1	8262	639	23	5		5	KIAA1279	10	70748846	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		70748846	64785901	35	9275										
PTEN	5728	broad.mit.edu	37	chr10	89624296	89624296	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aagaggatggattcgacttaGacttgacctgtatccatttc	9	8	0	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr10:89624296G>C	ENST00000371953.3	+	1	1427	c.70G>C	c.(70-72)Gac>Cac	p.D24H		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	24	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(13)|p.D24Y(4)|p.D24N(2)|p.D24fs*20(2)|p.D24_L25del(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATTCGACTTAGACTTGACCTG	0.463		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			30	47					0	0	1	0	0	C	89624296	G	C	89624296	3	2	53	1	0	0	0	0	1	0	0	0	12786	942	33	2	72	2	PTEN	10	89624296	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	18875450	89624296	45910451	36	9276										
TDRD1	56165	broad.mit.edu	37	chr10	115981160	115981160	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	agacgatagaattgccagtgGataaaactatacaagcaaat	8	6	0	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr10:115981160G>T	ENST00000251864.2	+	20	2968	c.2815G>T	c.(2815-2817)Gat>Tat	p.D939Y	TDRD1_ENST00000369281.2_Missense_Mutation_p.D825Y|TDRD1_ENST00000422662.1_Missense_Mutation_p.D543Y|TDRD1_ENST00000369280.1_Missense_Mutation_p.D939Y|TDRD1_ENST00000369282.1_Missense_Mutation_p.D939Y	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	939					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		ATTGCCAGTGGATAAAACTAT	0.363													23	24					7.41877e-09	8.037e-09	1	1	0	T	115981160	G	T	115981160	3	4	53	1	0	0	0	0	1	0	0	0	15788	1174	41	2	2889	2	TDRD1	10	115981160	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	26356864	115981160	19553587	37	9277										
MMP21	118856	broad.mit.edu	37	chr10	127464289	127464289	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	agtggggacggctccaggtcCgagcggtcccggctgtggaa	18	11	0	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr10:127464289C>T	ENST00000368808.3	-	1	101	c.102G>A	c.(100-102)tcG>tcA	p.S34S		NM_147191.1	NP_671724.1	Q8N119	MMP21_HUMAN	matrix metallopeptidase 21	34					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	16		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GCTCCAGGTCCGAGCGGTCCC	0.677													19	46					0	0	1	0	0	T	127464289	C	T	127464289	2	4	53	1	0	0	0	0	0	0	0	1	9707	639	23	1		1	MMP21	10	127464289	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	11483129	127464289	8070458	38	9278										
PHOX2A	401	broad.mit.edu	37	chr11	71954958	71954958	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ggggctgtattggaagccgcCgggctggctgcaggcgccaa	18	11	0	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr11:71954958C>T	ENST00000298231.5	-	1	262	c.91G>A	c.(91-93)Ggc>Agc	p.G31S	PHOX2A_ENST00000544057.1_Intron	NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	31					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						TGGAAGCCGCCGGGCTGGCTG	0.716													4	11					0	0	1	0	0	T	71954958	C	T	71954958	3	4	53	1	0	0	0	0	1	0	0	0	11905	652	23	1	775	1	PHOX2A	11	71954958	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		71954958	63051558	39	9279										
CASP4	837	broad.mit.edu	37	chr11	104822679	104822679	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ttcatgaggacaaagcttgaGggcatctgtagattctcctg	11	8	3	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr11:104822679G>A	ENST00000444739.2	-	3	1226	c.316C>T	c.(316-318)Ctc>Ttc	p.L106F	CASP4_ENST00000393150.3_Missense_Mutation_p.L50F|CASP4_ENST00000531333.1_Intron	NM_001225.3	NP_001216.1	P49662	CASP4_HUMAN	caspase 4, apoptosis-related cysteine peptidase	106					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		CAAAGCTTGAGGGCATCTGTA	0.413													18	35					0	0	1	0	0	A	104822679	G	A	104822679	3	1	53	1	0	0	0	0	1	0	0	0	2691	1000	35	3	841	3	CASP4	11	104822679	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	32867721	104822679	30183837	40	9280										
JAM3	83700	broad.mit.edu	37	chr11	134009765	134009765	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ggctgcctgataggggctgtAaatctcaaatccagcaatcg	11	10	1	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr11:134009765A>G	ENST00000299106.4	+	2	255	c.96A>G	c.(94-96)gtA>gtG	p.V32V	JAM3_ENST00000441717.3_Silent_p.V32V|JAM3_ENST00000529443.2_Silent_p.V77V|JAM3_ENST00000524969.1_3'UTR			Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3	32					angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)	10	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		TAGGGGCTGTAAATCTCAAAT	0.438											OREG0021547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	31					0	0	1	0	0	G	134009765	A	G	134009765	2	3	53	1	0	0	0	0	0	0	0	1	7987	349	13	4		4	JAM3	11	134009765	Silent	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08	29187086	134009765	996751	41	9281										
SCNN1A	0	broad.mit.edu	37	chr12	6472683	6472683	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	caagctggaggccacgctacGggctcgacgggccccgtgag	16	14	0	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr12:6472683G>C	ENST00000358945.3	-	2	1050	c.610C>G	c.(610-612)Cgt>Ggt	p.R204G	SCNN1A_ENST00000540037.1_5'UTR|SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000396966.2_Missense_Mutation_p.R204G|SCNN1A_ENST00000228916.2_Missense_Mutation_p.R204G|SCNN1A_ENST00000543768.1_Missense_Mutation_p.R227G|SCNN1A_ENST00000360168.3_Missense_Mutation_p.R263G			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	204					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GCCACGCTACGGGCTCGACGG	0.741													18	10					0	0	1	0	0	C	6472683	G	C	6472683	3	2	53	1	0	0	0	0	1	0	0	0	13980	1116	39	5	1443	5	SCNN1A	12	6472683	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08		6472683	127379212	42	9282										
LRP1	4035	broad.mit.edu	37	chr12	57572304	57572304	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gctaaggccaacaagtggacCggccacaatgtcaccgtggt	12	12	1	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr12:57572304C>T	ENST00000243077.3	+	27	4990	c.4524C>T	c.(4522-4524)acC>acT	p.T1508T		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1508					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACAAGTGGACCGGCCACAATG	0.617													30	137					0	0	1	0	0	T	57572304	C	T	57572304	2	4	53	1	0	0	0	0	0	0	0	1	8995	639	23	1		1	LRP1	12	57572304	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	51099621	57572304	76279591	43	9283										
NOS1	4842	broad.mit.edu	37	chr12	117723945	117723945	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tggatcctgcccacacagcgCgaggcattccgccaggcgtg	13	15	0	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr12:117723945C>T	ENST00000317775.6	-	6	1939	c.1254G>A	c.(1252-1254)tcG>tcA	p.S418S	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.S418S	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	418					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCACACAGCGCGAGGCATTCC	0.562													31	55					0	0	1	0	0	T	117723945	C	T	117723945	2	4	53	1	0	0	0	0	0	0	0	1	10587	755	27	1		1	NOS1	12	117723945	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	60151641	117723945	16127950	44	9284										
DGKH	160851	broad.mit.edu	37	chr13	42763366	42763366	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aaaccttcctcccagaaagcCgtcaaaccaagggaaatcat	6	13	2	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr13:42763366C>G	ENST00000379274.2	+	15	1854	c.1425C>G	c.(1423-1425)gcC>gcG	p.A475A	DGKH_ENST00000261491.4_Silent_p.A611A|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000536612.1_Silent_p.A475A|DGKH_ENST00000540693.1_Silent_p.A611A|DGKH_ENST00000538674.1_Silent_p.A366A|DGKH_ENST00000337343.4_Silent_p.A611A			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	611					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CCCAGAAAGCCGTCAAACCAA	0.458													22	59					0	0	1	0	0	G	42763366	C	G	42763366	2	3	53	1	0	0	0	0	0	0	0	1	4498	639	23	5		5	DGKH	13	42763366	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		42763366	72406512	45	9285										
FAM124A	220108	broad.mit.edu	37	chr13	51825708	51825708	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	aggaggccatcgacaacgtcCtggcgtggatccaccccgac	12	15	0	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr13:51825708C>A	ENST00000322475.8	+	3	340	c.205C>A	c.(205-207)Ctg>Atg	p.L69M	FAM124A_ENST00000280057.6_Missense_Mutation_p.L105M	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	69										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CGACAACGTCCTGGCGTGGAT	0.692													10	33					7.48243e-07	8.0106e-07	1	1	0	A	51825708	C	A	51825708	3	1	53	1	0	0	0	0	1	0	0	0	5456	680	24	5	327	5	FAM124A	13	51825708	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	9062342	51825708	63344170	46	9286										
PCDH8	5100	broad.mit.edu	37	chr13	53422054	53422054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ggctgtgcggctcggccaggCgcacggtctgcagcccgttg	17	14	1	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr13:53422054C>T	ENST00000377942.3	-	1	721	c.518G>A	c.(517-519)cGc>cAc	p.R173H	PCDH8_ENST00000338862.4_Missense_Mutation_p.R173H	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	173	Cadherin 2.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCGGCCAGGCGCACGGTCTG	0.716													6	11					0	0	1	0	0	T	53422054	C	T	53422054	3	4	53	1	0	0	0	0	1	0	0	0	11563	768	27	1	2706	1	PCDH8	13	53422054	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	1596346	53422054	61747824	47	9287										
TBC1D4	9882	broad.mit.edu	37	chr13	75884163	75884163	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cacaagctcctcagttctttTgatttctttctttcttcaat	3	11	6	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr13:75884163T>C	ENST00000377636.3	-	14	2854	c.2508A>G	c.(2506-2508)tcA>tcG	p.S836S	TBC1D4_ENST00000431480.2_Silent_p.S828S|TBC1D4_ENST00000425511.1_Silent_p.S53S|TBC1D4_ENST00000377625.2_Silent_p.S773S	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	836						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TCAGTTCTTTTGATTTCTTTC	0.433													23	25					0	0	1	0	0	C	75884163	T	C	75884163	2	2	53	1	0	0	0	0	0	0	0	1	15681	1799	63	4		4	TBC1D4	13	75884163	Silent	SNP	T	TCGA-NF-A5CP-01A-12D-A28R-08	22462109	75884163	39285715	48	9288										
RBM26	64062	broad.mit.edu	37	chr13	79911276	79911276	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tcttctctatcgctctccgtAaatgcagaaatctccaatgc	5	13	4	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr13:79911276A>C	ENST00000438737.2	-	19	3134	c.2694T>G	c.(2692-2694)ttT>ttG	p.F898L	RBM26_ENST00000438724.1_Missense_Mutation_p.F874L|RBM26_ENST00000267229.7_Missense_Mutation_p.F871L			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	898	RRM 2.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CGCTCTCCGTAAATGCAGAAA	0.507													14	35					0	0	1	0	0	C	79911276	A	C	79911276	3	2	53	1	0	0	0	0	1	0	0	0	13177	359	13	4	345	4	RBM26	13	79911276	Missense_Mutation	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08	4027113	79911276	35258602	49	9289										
OR11H12	440153	broad.mit.edu	37	chr14	19377911	19377911	+	Frame_Shift_Del	DEL	C	C	-													0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ttcctttcagagaaaaaaaaCatctcctttgctggatgttt							TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr14:19377911delC	ENST00000550708.1	+	1	390	c.318delC	c.(316-318)aafs	p.N106fs		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGAAAAAAAACATCTCCTTTG	0.388													22	82	---	---	---	---						-	19377911	C	-	19377911	7	5	53	1	0	1	0	1	0	0	0	0	10974	477	17	0	320	0	OR11H12	14	19377911	Frame_Shift_Del	DEL	C	TCGA-NF-A5CP-01A-12D-A28R-08		19377911	87971629	50	9290										
ATP10A	57194	broad.mit.edu	37	chr15	25928532	25928532	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtcacgagcgggggaagtgaCgagaagagcagattaaagaa	16	5	1	5			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr15:25928532C>T	ENST00000356865.6	-	17	3504	c.3393G>A	c.(3391-3393)tcG>tcA	p.S1131S		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1131					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGGGAAGTGACGAGAAGAGCA	0.527													4	63					0	0	1	0	0	T	25928532	C	T	25928532	2	4	53	1	0	0	0	0	0	0	0	1	1115	523	19	1		1	ATP10A	15	25928532	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		25928532	76602860	51	9291										
MAP1A	4130	broad.mit.edu	37	chr15	43820144	43820144	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ctcacacctggggcctgcccGacccagtctggacttccctg	10	18	2	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr15:43820144G>A	ENST00000382031.1	+	5	7218	c.7187G>A	c.(7186-7188)cGa>cAa	p.R2396Q	MAP1A_ENST00000300231.5_Missense_Mutation_p.R2158Q|MAP1A_ENST00000399453.1_Missense_Mutation_p.R2158Q			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2158						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGGCCTGCCCGACCCAGTCTG	0.617													89	87					0	0	1	0	0	A	43820144	G	A	43820144	3	1	53	1	0	0	0	0	1	0	0	0	9276	1058	37	1	6475	1	MAP1A	15	43820144	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	17891612	43820144	58711248	52	9292										
SRRM2	23524	broad.mit.edu	37	chr16	2816009	2816009	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tcactcaaggtcacctgcccGgcaggaaagttcccggacct	10	15	3	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr16:2816009G>A	ENST00000301740.8	+	11	6029	c.5480G>A	c.(5479-5481)cGg>cAg	p.R1827Q		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1827	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						TCACCTGCCCGGCAGGAAAGT	0.652													10	45					0	0	1	0	0	A	2816009	G	A	2816009	3	1	53	1	0	0	0	0	1	0	0	0	15224	1116	39	1	5518	1	SRRM2	16	2816009	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08		2816009	87538744	53	9293										
SBK1	388228	broad.mit.edu	37	chr16	28331566	28331566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cgacttcggcatgacgcgccGcgtgggctgccgcgtcaagc	15	15	1	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr16:28331566G>A	ENST00000341901.4	+	4	1388	c.599G>A	c.(598-600)cGc>cAc	p.R200H		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	200	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						ATGACGCGCCGCGTGGGCTGC	0.726													17	14					0	0	1	0	0	A	28331566	G	A	28331566	3	1	53	1	0	0	0	0	1	0	0	0	13912	1087	38	1	609	1	SBK1	16	28331566	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	25515557	28331566	62023187	54	9294										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			45	8					0	0	1	0	0	T	7577538	C	T	7577538	3	4	53	1	0	0	0	0	1	0	0	0	16441	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		7577538	73617672	55	9295										
NF1	4763	broad.mit.edu	37	chr17	29701048	29701048	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	caggaatcgacaaggagaacGttgaactctcccctaccact	8	13	1	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr17:29701048G>A	ENST00000358273.4	+	58	8778	c.8395G>A	c.(8395-8397)Gtt>Att	p.V2799I	NF1_ENST00000356175.3_Missense_Mutation_p.V2778I|NF1_ENST00000444181.2_Missense_Mutation_p.V592I	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2799					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAAGGAGAACGTTGAACTCTC	0.493			"D, Mis, N, F, S, O"		"neurofibroma, glioma"	"neurofibroma, glioma"			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			6	62					0	0	1	0	0	A	29701048	G	A	29701048	3	1	53	1	0	0	0	0	1	0	0	0	10402	1145	40	1	8686	1	NF1	17	29701048	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	22123510	29701048	51494162	56	9296										
CD300C	10871	broad.mit.edu	37	chr17	72541016	72541016	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtcctgtgttccttctcataGcgacactgcacactcaggga	9	13	2	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr17:72541016G>A	ENST00000330793.1	-	2	492	c.132C>T	c.(130-132)cgC>cgT	p.R44R		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	44	Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						CCTTCTCATAGCGACACTGCA	0.532													29	34					0	0	1	0	0	A	72541016	G	A	72541016	2	1	53	1	0	0	0	0	0	0	0	1	3019	958	34	3		3	CD300C	17	72541016	Silent	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	42839968	72541016	8654194	57	9297										
ENPP7	339221	broad.mit.edu	37	chr17	77709178	77709178	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tcaacctgatcatcacatccGaccacggcatgacgaccgtg	8	15	3	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr17:77709178G>A	ENST00000328313.5	+	3	957	c.736G>A	c.(736-738)Gac>Aac	p.D246N		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	246					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CATCACATCCGACCACGGCAT	0.612													7	94					0	0	1	0	0	A	77709178	G	A	77709178	3	1	53	1	0	0	0	0	1	0	0	0	5163	1058	37	1	746	1	ENPP7	17	77709178	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	5168162	77709178	3486032	58	9298										
ASPSCR1	79058	broad.mit.edu	37	chr17	79974988	79974988	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cccaagtggctgaagctgccGggtactgcggctgggtggaa	17	10	0	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr17:79974988G>A	ENST00000306729.7	+	16	2026	c.1930_splice	c.e16+1	p.P643_splice	ASPSCR1_ENST00000306739.4_Splice_Site_p.P549_splice|ASPSCR1_ENST00000580534.1_Splice_Site_p.P497_splice|ASPSCR1_ENST00000582404.1_3'UTR	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	549							protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TGAAGCTGCCGGGTACTGCGG	0.721			T	TFE3	alveolar soft part sarcoma								11	20					0	0	1	0	0	A	79974988	G	A	79974988	5	1	53	1	0	0	0	0	0	0	1	0	1058	1130	39	1	1705	1	ASPSCR1	17	79974988	Splice_Site	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	2265810	79974988	1220222	59	9299										
ALPK2	115701	broad.mit.edu	37	chr18	56204502	56204502	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	actataactggctggtgtggCtgtggtgtctgcggcactag	15	8	1	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr18:56204502C>T	ENST00000361673.3	-	5	3130	c.2917G>A	c.(2917-2919)Gcc>Acc	p.A973T	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	973							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GCTGGTGTGGCTGTGGTGTCT	0.458													4	54					0	0	1	0	0	T	56204502	C	T	56204502	3	4	53	1	0	0	0	0	1	0	0	0	541	797	28	3	3631	3	ALPK2	18	56204502	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		56204502	21872746	60	9300										
OCEL1	79629	broad.mit.edu	37	chr19	17337954	17337954	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gggcgccaagaagcctattgGagccatccctaaggggcata	13	11	0	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr19:17337954G>C	ENST00000215061.4	+	3	442	c.398G>C	c.(397-399)gGa>gCa	p.G133A	OCEL1_ENST00000597836.1_Missense_Mutation_p.G77A|OCEL1_ENST00000601529.1_Missense_Mutation_p.G133A|OCEL1_ENST00000601576.1_3'UTR	NM_024578.1	NP_078854.1	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	133										central_nervous_system(2)|endometrium(2)|kidney(1)|lung(2)	7						AAGCCTATTGGAGCCATCCCT	0.592													12	142					0	0	1	0	0	C	17337954	G	C	17337954	3	2	53	1	0	0	0	0	1	0	0	0	10863	1174	41	2	408	2	OCEL1	19	17337954	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08		17337954	41791029	61	9301										
ZNF571	51276	broad.mit.edu	37	chr19	38056900	38056900	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtagctgaaaccttgtctgcAttccttacatttgtacaatt	6	9	1	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr19:38056900A>G	ENST00000328550.2	-	4	529	c.430T>C	c.(430-432)Tgc>Cgc	p.C144R	ZNF571-AS1_ENST00000586013.1_RNA|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571-AS1_ENST00000589802.1_RNA|ZNF571_ENST00000451802.2_Missense_Mutation_p.C144R|ZNF540_ENST00000592533.1_Intron|ZNF571_ENST00000590751.1_Intron|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571_ENST00000358744.3_Missense_Mutation_p.C144R|ZNF571-AS1_ENST00000585578.1_RNA|ZNF571_ENST00000593133.1_Missense_Mutation_p.C144R|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571-AS1_ENST00000592392.1_RNA|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTTGTCTGCATTCCTTACAT	0.353													6	54					0	0	1	0	0	G	38056900	A	G	38056900	3	3	53	1	0	0	0	0	1	0	0	0	18059	217	8	4	1403	4	ZNF571	19	38056900	Missense_Mutation	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08	20718946	38056900	21072083	62	9302										
ZNF470	388566	broad.mit.edu	37	chr19	57089191	57089191	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tgagaaagccttcagccatcGtgggtctcttactcttcatc	8	12	4	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr19:57089191G>A	ENST00000330619.8	+	6	2080	c.1394G>A	c.(1393-1395)cGt>cAt	p.R465H	ZNF470_ENST00000391709.3_Missense_Mutation_p.R465H|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TTCAGCCATCGTGGGTCTCTT	0.443													34	63					0	0	1	0	0	A	57089191	G	A	57089191	3	1	53	1	0	0	0	0	1	0	0	0	17985	1145	40	1	1408	1	ZNF470	19	57089191	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	19032291	57089191	2039792	63	9303										
CHMP2A	27243	broad.mit.edu	37	chr19	59063715	59063716	+	Frame_Shift_Del	DEL	AC	AC	-													0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gagtgtctggatcttgagggAcacagcctggatgttggccc							TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr19:59063715_59063716delAC	ENST00000600118.1	-	2	683_684	c.258_259delGT	c.(256-261)gtccfs	p.VS86fs	CHMP2A_ENST00000601220.1_Frame_Shift_Del_p.VS86fs|CHMP2A_ENST00000312547.2_Frame_Shift_Del_p.VS86fs			O43633	CHM2A_HUMAN	charged multivesicular body protein 2A	86	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	7		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		ATCTTGAGGGACACAGCCTGGA	0.545													55	123	---	---	---	---						-	59063716	AC	-	59063715	7	5	53	1	0	1	0	1	0	0	0	0	3376	275	10	0	425	0	CHMP2A	19	59063715	Frame_Shift_Del	DEL	AC	TCGA-NF-A5CP-01A-12D-A28R-08	1974524	59063715	65268	64	9304										
C21orf2	755	broad.mit.edu	37	chr21	45753071	45753071	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gctcagccaggctggggatgCggttcctccgcaggtacagc	15	13	1	0	rs140451304		TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr21:45753071C>T	ENST00000339818.4	-	4	425	c.218G>A	c.(217-219)cGc>cAc	p.R73H	C21orf2_ENST00000397956.3_Missense_Mutation_p.R73H|C21orf2_ENST00000496321.1_5'UTR|C21orf2_ENST00000325223.7_Missense_Mutation_p.R73H|AP001062.7_ENST00000448927.1_RNA	NM_004928.2	NP_004919.1	O43822	CU002_HUMAN	chromosome 21 open reading frame 2	73										endometrium(2)	2				Colorectal(79;0.0806)		GCTGGGGATGCGGTTCCTCCG	0.677													10	19					0	0	1	0	0	T	45753071	C	T	45753071	3	4	53	1	0	0	0	0	1	0	0	0	2137	768	27	1	568	1	C21orf2	21	45753071	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		45753071	2376824	65	9305										
CHEK2	11200	broad.mit.edu	37	chr22	29092971	29092971	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtataataccgttttcatgaAggtactacacagaaaggcag	9	7	1	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chr22:29092971A>C	ENST00000544772.1	-	11	1786	c.350T>G	c.(349-351)cTt>cGt	p.L117R	CHEK2_ENST00000464581.1_5'UTR|CHEK2_ENST00000348295.3_Intron|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Missense_Mutation_p.L338R|CHEK2_ENST00000382580.2_Missense_Mutation_p.L381R|CHEK2_ENST00000328354.6_Missense_Mutation_p.L338R|CHEK2_ENST00000403642.1_Missense_Mutation_p.L247R|CHEK2_ENST00000382578.1_Missense_Mutation_p.L247R|CHEK2_ENST00000402731.1_Intron|CHEK2_ENST00000404276.1_Missense_Mutation_p.L338R	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	338	FHA.		R -> G (in dbSNP:rs28909982).		cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						GTTTTCATGAAGGTACTACAC	0.398			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	12					0	0	1	0	0	C	29092971	A	C	29092971	3	2	53	1	0	0	0	0	1	0	0	0	3357	72	3	4	642	4	CHEK2	22	29092971	Missense_Mutation	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08		29092971	22211595	66	9306										
MAGEB2	4113	broad.mit.edu	37	chrX	30236752	30236752	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	gtgagaaacgccgcaaggccCgagatgagacccggggtctc	15	12	1	3			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:30236752C>T	ENST00000378988.4	+	2	156	c.55C>T	c.(55-57)Cga>Tga	p.R19*		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	19							protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						CCGCAAGGCCCGAGATGAGAC	0.547													18	26					0	0	1	0	0	T	30236752	C	T	30236752	4	4	53	1	0	0	0	0	0	1	0	0	9225	644	23	1	57	1	MAGEB2	23	30236752	Nonsense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08		30236752	125033808	67	9307										
DMD	1756	broad.mit.edu	37	chrX	31525450	31525450	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ccacttgaagttcatgttatCcaaacgtctttgtaacagga	7	9	2	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:31525450C>G	ENST00000357033.4	-	56	8544	c.8338G>C	c.(8338-8340)Gat>Cat	p.D2780H	DMD_ENST00000378707.3_Missense_Mutation_p.D320H|DMD_ENST00000474231.1_Missense_Mutation_p.D320H|DMD_ENST00000378677.2_Missense_Mutation_p.D2776H|DMD_ENST00000343523.2_Missense_Mutation_p.D320H|DMD_ENST00000445312.1_5'UTR|DMD_ENST00000541735.1_Missense_Mutation_p.D320H|DMD_ENST00000359836.1_Missense_Mutation_p.D320H	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2780					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCATGTTATCCAAACGTCTT	0.413													20	27					0	0	1	0	0	G	31525450	C	G	31525450	3	3	53	1	0	0	0	0	1	0	0	0	4608	855	30	2	2929	2	DMD	23	31525450	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	1288698	31525450	123745110	68	9308										
AKAP4	8852	broad.mit.edu	37	chrX	49958838	49958838	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	agctgctgtcatttctagacGtaggttttgaggtctgttca	11	7	4	2			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:49958838G>A	ENST00000376056.2	-	5	649	c.499C>T	c.(499-501)Cgt>Tgt	p.R167C	AKAP4_ENST00000376064.3_Missense_Mutation_p.R167C|AKAP4_ENST00000358526.2_Missense_Mutation_p.R176C|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Missense_Mutation_p.R167C			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	176					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					ATTTCTAGACGTAGGTTTTGA	0.448													49	90					0	0	1	0	0	A	49958838	G	A	49958838	3	1	53	1	0	0	0	0	1	0	0	0	450	1145	40	1	2046	1	AKAP4	23	49958838	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	18433388	49958838	105311722	69	9309										
MED12	9968	broad.mit.edu	37	chrX	70338671	70338671	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ggccgcggctggggcctcccGatgtttaccctcaggacccc	13	17	1	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:70338671G>T	ENST00000333646.6	+	1	266	c.67G>T	c.(67-69)Gat>Tat	p.D23Y	MED12_ENST00000374102.1_Missense_Mutation_p.D23Y|MED12_ENST00000374080.3_Missense_Mutation_p.D23Y	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	23					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.D23Y(2)		breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GGGGCCTCCCGATGTTTACCC	0.677			"M, S"		uterine leiomyoma		Opitz-Kaveggia Syndrome						16	24					0.000566183	0.000585485	1	1	0	T	70338671	G	T	70338671	3	4	53	1	0	0	0	0	1	0	0	0	9477	1058	37	2	69	2	MED12	23	70338671	Missense_Mutation	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	20379833	70338671	84931889	70	9310										
NAP1L2	4674	broad.mit.edu	37	chrX	72433770	72433770	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	taccataccctcctcattacCatacatctcttcatgacaca	1	16	3	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:72433770C>T	ENST00000373517.3	-	1	914	c.559G>A	c.(559-561)Ggt>Agt	p.G187S	NAP1L2_ENST00000536638.1_Missense_Mutation_p.G45S	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	187	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex		p.G187S(1)		NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCCTCATTACCATACATCTCT	0.408													9	81					0	0	1	0	0	T	72433770	C	T	72433770	3	4	53	1	0	0	0	0	1	0	0	0	10204	594	21	3	827	3	NAP1L2	23	72433770	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	2095099	72433770	82836790	71	9311										
P2RY10	0	broad.mit.edu	37	chrX	78216443	78216443	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ctcaagcccttcagggccagAgactggaagcgtaggtacga	13	11	2	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:78216443A>T	ENST00000171757.2	+	4	706	c.426A>T	c.(424-426)agA>agT	p.R142S	P2RY10_ENST00000475374.1_3'UTR|P2RY10_ENST00000544091.1_Missense_Mutation_p.R142S	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	142						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						TCAGGGCCAGAGACTGGAAGC	0.498													9	98					0	0	1	0	0	T	78216443	A	T	78216443	3	4	53	1	0	0	0	0	1	0	0	0	11393	301	11	4	428	4	P2RY10	23	78216443	Missense_Mutation	SNP	A	TCGA-NF-A5CP-01A-12D-A28R-08	5782673	78216443	77054117	72	9312										
ESX1	80712	broad.mit.edu	37	chrX	103497474	103497474	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	atttactgacctgcactctgTcttcagtcaaattcaggcgt	7	11	5	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:103497474T>A	ENST00000372588.4	-	3	625	c.542A>T	c.(541-543)gAc>gTc	p.D181V		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	181					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						CTGCACTCTGTCTTCAGTCAA	0.393													64	136					0	0	1	0	0	A	103497474	T	A	103497474	3	1	53	1	0	0	0	0	1	0	0	0	5291	1667	58	4	686	4	ESX1	23	103497474	Missense_Mutation	SNP	T	TCGA-NF-A5CP-01A-12D-A28R-08	25281031	103497474	51773086	73	9313										
ACSL4	2182	broad.mit.edu	37	chrX	108911498	108911498	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	ggccttgacctttttaaacaGtaaccttaataaagggagga	9	7	0	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:108911498G>A	ENST00000340800.2	-	12	1774	c.1270C>T	c.(1270-1272)Ctg>Ttg	p.L424L	ACSL4_ENST00000348502.6_Silent_p.L383L|ACSL4_ENST00000469796.2_Silent_p.L424L	NM_022977.2	NP_075266.1	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	424					fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)	22					Icosapent(DB00159)|Troglitazone(DB00197)	TTTTTAAACAGTAACCTTAAT	0.438													35	36					0	0	1	0	0	A	108911498	G	A	108911498	2	1	53	1	0	0	0	0	0	0	0	1	179	1020	36	3		3	ACSL4	23	108911498	Silent	SNP	G	TCGA-NF-A5CP-01A-12D-A28R-08	5414024	108911498	46359062	74	9314										
MAGEA12	4111	broad.mit.edu	37	chrX	151899865	151899865	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cgtgctcagactcactcttcCccctctctaaaagcccattc	4	18	4	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:151899865C>T	ENST00000393900.3	-	3	1289	c.936G>A	c.(934-936)ggG>ggA	p.G312G	CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Silent_p.G312G|MAGEA12_ENST00000357916.4_Silent_p.G312G	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	312										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CTCACTCTTCCCCCTCTCTAA	0.547													80	102					0	0	1	0	0	T	151899865	C	T	151899865	2	4	53	1	0	0	0	0	0	0	0	1	9211	610	22	3		3	MAGEA12	23	151899865	Silent	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	42988367	151899865	3370695	75	9315										
TREX2	11219	broad.mit.edu	37	chrX	152713287	152713287	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	tcgatcttgggagagggcttCctgcccgccccatcctgtgc	12	15	1	1			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:152713287C>T	ENST00000334497.2	-	10	1155	c.14G>A	c.(13-15)gGa>gAa	p.G5E	HAUS7_ENST00000370219.3_3'UTR|TREX2_ENST00000402951.1_Missense_Mutation_p.G5E|HAUS7_ENST00000370211.4_3'UTR|HAUS7_ENST00000421080.2_3'UTR|TREX2_ENST00000370232.1_Missense_Mutation_p.G5E|TREX2_ENST00000393862.2_5'UTR|HAUS7_ENST00000484394.1_5'UTR|TREX2_ENST00000330912.2_5'UTR|TREX2_ENST00000414588.1_5'UTR|TREX2_ENST00000338525.2_5'UTR			Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	5					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(2)	11	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGAGGGCTTCCTGCCCGCCC	0.537								Editing and processing nucleases					111	249					0	0	1	0	0	T	152713287	C	T	152713287	3	4	53	1	0	0	0	0	1	0	0	0	16537	870	30	3		3	TREX2	23	152713287	Missense_Mutation	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	813422	152713287	2557273	76	9316										
ARHGAP4	393	broad.mit.edu	37	chrX	153175625	153175625	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.025974025974026	2	1	0.284181377639322	1.53457943925234	0	0.333333333333333	1	0	cggcagcaccaagggtgtacCccaggcagctggcggaaggc	16	13	0	0			TCGA-NF-A5CP-01A-12D-A28R-08	TCGA-NF-A5CP-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a5cd1b0-e7bd-4f5f-afb5-e9fc3be14d5d	9abdb8aa-e659-4785-9f8a-3664d9dcca2a	g.chrX:153175625C>T	ENST00000370028.3	-	18	2333	c.2276_splice	c.e18+1	p.G759_splice	ARHGAP4_ENST00000370016.1_Splice_Site_p.G698_splice|ARHGAP4_ENST00000467421.1_5'UTR|ARHGAP4_ENST00000350060.5_Splice_Site_p.G719_splice|ARHGAP4_ENST00000393721.1_Splice_Site_p.G541_splice|ARHGAP4_ENST00000537206.1_Splice_Site_p.G696_splice	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	719	SH3.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AAGGGTGTACCCCAGGCAGCT	0.677													26	26					0	0	1	0	0	T	153175625	C	T	153175625	5	4	53	1	0	0	0	0	0	0	1	0	882	637	22	3	708	3	ARHGAP4	23	153175625	Splice_Site	SNP	C	TCGA-NF-A5CP-01A-12D-A28R-08	462338	153175625	2094935	77	9317										
CROCC	9696	broad.mit.edu	37	chr1	17270624	17270624	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	caacctggcccacagcctgcAggtggcccagcagcaggccg	13	17	0	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr1:17270624A>G	ENST00000375541.5	+	14	1907	c.1838A>G	c.(1837-1839)cAg>cGg	p.Q613R	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	613					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CACAGCCTGCAGGTGGCCCAG	0.697													3	13					0	0	1	0	0	G	17270624	A	G	17270624	3	3	54	1	0	0	0	0	1	0	0	0	3916	188	7	4	1892	4	CROCC	1	17270624	Missense_Mutation	SNP	A	TCGA-NG-A4VU-01A-11D-A28R-08		17270624	231979997	1	9318										
COL11A1	1301	broad.mit.edu	37	chr1	103453188	103453188	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	aatttaaagtcatttaccaaCcttttctcctgcttgacctg	4	11	2	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr1:103453188C>A	ENST00000358392.2	-	30	2856		c.e30+1		COL11A1_ENST00000370096.3_Splice_Site|COL11A1_ENST00000512756.1_Splice_Site|COL11A1_ENST00000353414.4_Splice_Site	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CATTTACCAACCTTTTCTCCT	0.438													8	26					0.0381472	0.0387625	1	1	0	A	103453188	C	A	103453188	5	1	54	1	0	0	0	0	0	0	1	0	3690	521	18	5	3069	5	COL11A1	1	103453188	Splice_Site	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	86182564	103453188	145797433	2	9319										
ATP8B2	57198	broad.mit.edu	37	chr1	154315408	154315408	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ccgcctcctttccctgtgtcAtactgtcatgtcagaagaaa	7	13	3	2			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr1:154315408A>G	ENST00000368489.3	+	15	1523	c.1523A>G	c.(1522-1524)cAt>cGt	p.H508R		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	494					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCCTGTGTCATACTGTCATG	0.572													46	56					0	0	1	0	0	G	154315408	A	G	154315408	3	3	54	1	0	0	0	0	1	0	0	0	1193	217	8	4	1711	4	ATP8B2	1	154315408	Missense_Mutation	SNP	A	TCGA-NG-A4VU-01A-11D-A28R-08	50862220	154315408	94935213	3	9320										
PIGR	5284	broad.mit.edu	37	chr1	207110846	207110846	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	cagagatactgcccagcatcGctgagcctgagttggttgat	12	10	0	4			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr1:207110846G>A	ENST00000356495.4	-	4	822	c.639C>T	c.(637-639)agC>agT	p.S213S		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	213	Ig-like V-type 2.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCCCAGCATCGCTGAGCCTGA	0.483													23	68					0	0	1	0	0	A	207110846	G	A	207110846	2	1	54	1	0	0	0	0	0	0	0	1	11944	1078	38	1		1	PIGR	1	207110846	Silent	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	52795438	207110846	42139775	4	9321										
HEATR5B	54497	broad.mit.edu	37	chr2	37230808	37230808	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tagaaggcggtgcaaaacacTcagcaactcaacacctatca	7	12	3	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr2:37230808T>C	ENST00000233099.5	-	31	5022	c.4927A>G	c.(4927-4929)Agt>Ggt	p.S1643G	HEATR5B_ENST00000354531.2_Missense_Mutation_p.S1643G	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1643							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				TGCAAAACACTCAGCAACTCA	0.343													14	29					0	0	1	0	0	C	37230808	T	C	37230808	3	2	54	1	0	0	0	0	1	0	0	0	7072	1551	54	4	1312	4	HEATR5B	2	37230808	Missense_Mutation	SNP	T	TCGA-NG-A4VU-01A-11D-A28R-08		37230808	205968565	5	9322										
TET3	200424	broad.mit.edu	37	chr2	74329129	74329129	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ctgggccagcaggaggccaaGctctacgggaagaagcgcaa	15	11	1	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr2:74329129G>C	ENST00000409262.3	+	9	4809	c.4809G>C	c.(4807-4809)aaG>aaC	p.K1603N		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1603							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGGAGGCCAAGCTCTACGGGA	0.687													16	23					0	0	1	0	0	C	74329129	G	C	74329129	3	2	54	1	0	0	0	0	1	0	0	0	15829	962	34	5	4843	5	TET3	2	74329129	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	37098321	74329129	168870244	6	9323										
THSD7B	80731	broad.mit.edu	37	chr2	137917826	137917826	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ttatgtgtgggacccgccccGttgccctctcagctctgcaa	10	15	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr2:137917826G>A	ENST00000409968.1	+	6	1591	c.1413G>A	c.(1411-1413)ccG>ccA	p.P471P	THSD7B_ENST00000413152.2_Silent_p.P440P|THSD7B_ENST00000272643.3_Silent_p.P471P|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GACCCGCCCCGTTGCCCTCTC	0.512													39	48					0	0	1	0	0	A	137917826	G	A	137917826	2	1	54	1	0	0	0	0	0	0	0	1	15939	1132	40	1		1	THSD7B	2	137917826	Silent	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	63588697	137917826	105281547	7	9324										
ITPR1	3708	broad.mit.edu	37	chr3	4716886	4716886	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ttccccattagcaagatggcGaaaggagaagagaataaagg	12	6	0	3			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr3:4716886G>A	ENST00000354582.6	+	23	3083	c.2733G>A	c.(2731-2733)gcG>gcA	p.A911A	ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.A911A|ITPR1_ENST00000443694.2_Silent_p.A896A|ITPR1_ENST00000456211.2_Silent_p.A896A|ITPR1_ENST00000302640.8_Silent_p.A896A|ITPR1_ENST00000423119.2_Silent_p.A911A			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	911					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCAAGATGGCGAAAGGAGAAG	0.443													25	38					0	0	1	0	0	A	4716886	G	A	4716886	2	1	54	1	0	0	0	0	0	0	0	1	7963	1045	37	1		1	ITPR1	3	4716886	Silent	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08		4716886	193305544	8	9325										
OXTR	5021	broad.mit.edu	37	chr3	8809318	8809318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gatgaagacggcccagcagtCgaagacgccgtcagccacct	12	14	1	3			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr3:8809318C>T	ENST00000316793.3	-	3	1180	c.556G>A	c.(556-558)Gac>Aac	p.D186N	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	186					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GCCCAGCAGTCGAAGACGCCG	0.662													32	31					0	0	1	0	0	T	8809318	C	T	8809318	3	4	54	1	0	0	0	0	1	0	0	0	11384	884	31	1	621	1	OXTR	3	8809318	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	4092432	8809318	189213112	9	9326										
FBXW7	0	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gccatcatattgaacacagcGgactgctgcaacatgaccca	8	13	1	2	rs149680468		TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr4:153247289G>C	ENST00000281708.4	-	10	2742	c.1513C>G	c.(1513-1515)Cgc>Ggc	p.R505G	FBXW7_ENST00000603841.1_Missense_Mutation_p.R505G|FBXW7_ENST00000263981.5_Missense_Mutation_p.R425G|FBXW7_ENST00000603548.1_Missense_Mutation_p.R505G|FBXW7_ENST00000296555.5_Missense_Mutation_p.R387G|FBXW7_ENST00000393956.3_Missense_Mutation_p.R329G	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	505			R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R505C(60)|p.R505G(18)|p.R425C(14)|p.R266C(13)|p.R425G(9)|p.R266G(9)|p.R387G(6)|p.R387C(3)|p.R505S(3)|p.R387S(1)|p.?(1)|p.R425S(1)|p.R266S(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			"Mis, N, D, F"		"colorectal, endometrial, T-ALL"								36	44					0	0	1	0	0	C	153247289	G	C	153247289	3	2	54	1	0	0	0	0	1	0	0	0	5801	1116	39	5	622	5	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08		153247289	37906987	10	9327										
PALLD	23022	broad.mit.edu	37	chr4	169825035	169825035	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	agatgatgatgggaattataCaattatggctgcaaaccctc	9	7	0	3			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr4:169825035C>T	ENST00000335742.7	+	15	3432	c.2075C>T	c.(2074-2076)aCa>aTa	p.T692I	PALLD_ENST00000512127.1_Missense_Mutation_p.T468I|CBR4_ENST00000509108.1_Intron|PALLD_ENST00000505667.1_Missense_Mutation_p.T867I|PALLD_ENST00000507735.1_Missense_Mutation_p.T363I|PALLD_ENST00000261509.6_Missense_Mutation_p.T850I			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1074	Interaction with ARGBP2, SPIN90 and SRC.|Pro-rich.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GGGAATTATACAATTATGGCT	0.443									Pancreatic Cancer, Familial Clustering of				14	20					0	0	1	0	0	T	169825035	C	T	169825035	3	4	54	1	0	0	0	0	1	0	0	0	11453	478	17	3	3161	3	PALLD	4	169825035	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	16577746	169825035	21329241	11	9328										
PCDHB6	0	broad.mit.edu	37	chr5	140532009	140532009	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ggcctcggtgggtcgctactCggtgcccgagggtccctttc	15	14	0	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr5:140532009C>T	ENST00000231136.1	+	1	2171	c.2171C>T	c.(2170-2172)tCg>tTg	p.S724L	PCDHB6_ENST00000543635.1_Missense_Mutation_p.S588L	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		724					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.S724L(1)		cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCGCTACTCGGTGCCCGAG	0.652													12	157					0	0	1	0	0	T	140532009	C	T	140532009	3	4	54	1	0	0	0	0	1	0	0	0	11592	893	31	1	2173	1	PCDHB6	5	140532009	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		140532009	40383251	12	9329										
C5orf46	389336	broad.mit.edu	37	chr5	147281275	147281275	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	aggcttaggaatttggggaaGtctggctttgggtctttgcc	15	6	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr5:147281275G>A	ENST00000515291.1	-	2	168	c.132C>T	c.(130-132)gaC>gaT	p.D44D	C5orf46_ENST00000318315.4_Silent_p.D44D|C5orf46_ENST00000510432.1_5'UTR			Q6UWT4	CE046_HUMAN	chromosome 5 open reading frame 46	44						extracellular region				NS(1)|lung(1)|prostate(1)	3						ATTTGGGGAAGTCTGGCTTTG	0.502													11	21					0	0	1	0	0	A	147281275	G	A	147281275	2	1	54	1	0	0	0	0	0	0	0	1	2320	1020	36	3		3	C5orf46	5	147281275	Silent	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	6749266	147281275	33633985	13	9330										
ADAMTS2	9509	broad.mit.edu	37	chr5	178557078	178557078	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	cttcatttaagatgaacttgCctgtctccaggttcttgacg	8	10	3	3			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr5:178557078C>A	ENST00000251582.7	-	16	2413	c.2312G>T	c.(2311-2313)gGc>gTc	p.G771V		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	771	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GATGAACTTGCCTGTCTCCAG	0.572													33	2					6.70999e-13	7.28843e-13	1	1	0	A	178557078	C	A	178557078	3	1	54	1	0	0	0	0	1	0	0	0	264	739	26	5	1351	5	ADAMTS2	5	178557078	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	31275803	178557078	2358182	14	9331										
TBC1D9B	23061	broad.mit.edu	37	chr5	179301924	179301924	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gcccagcatggtcatggcctCgccctcgtcgctgcagccca	11	18	1	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr5:179301924C>T	ENST00000356834.3	-	12	2201	c.2164G>A	c.(2164-2166)Gag>Aag	p.E722K	TBC1D9B_ENST00000355235.3_Missense_Mutation_p.E722K	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	722						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTCATGGCCTCGCCCTCGTCG	0.647													48	4					0	0	1	0	0	T	179301924	C	T	179301924	3	4	54	1	0	0	0	0	1	0	0	0	15687	893	31	1	1632	1	TBC1D9B	5	179301924	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	744846	179301924	1613336	15	9332										
BAI3	577	broad.mit.edu	37	chr6	70070975	70070975	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gagcttagcaatccatgtttGaaaaaagaaaatagtgaatt	8	4	0	3			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr6:70070975G>C	ENST00000370598.1	+	29	4631	c.3810G>C	c.(3808-3810)ttG>ttC	p.L1270F	BAI3_ENST00000238918.8_Missense_Mutation_p.L476F|BAI3_ENST00000546190.1_Missense_Mutation_p.L234F	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1270					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATCCATGTTTGAAAAAAGAAA	0.403													11	17					0	0	1	0	0	C	70070975	G	C	70070975	3	2	54	1	0	0	0	0	1	0	0	0	1298	1281	45	2	3916	2	BAI3	6	70070975	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08		70070975	101044092	16	9333										
DNAH11	8701	broad.mit.edu	37	chr7	21757493	21757493	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ctgcatgcttggataaactgAgaacaagctttaaaaccatc	7	9	0	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr7:21757493A>G	ENST00000328843.6	+	44	7136	c.7105A>G	c.(7105-7107)Aga>Gga	p.R2369G	DNAH11_ENST00000409508.3_Missense_Mutation_p.R2362G			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2369	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GGATAAACTGAGAACAAGCTT	0.423									Kartagener syndrome				4	79					0	0	1	0	0	G	21757493	A	G	21757493	3	3	54	1	0	0	0	0	1	0	0	0	4627	296	11	4	7276	4	DNAH11	7	21757493	Missense_Mutation	SNP	A	TCGA-NG-A4VU-01A-11D-A28R-08		21757493	137381170	17	9334										
ATP6V0A4	50617	broad.mit.edu	37	chr7	138394427	138394427	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ctccatgatcagaaggatggCtactgtcaggacagcaaata	10	9	2	2			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr7:138394427C>G	ENST00000310018.2	-	21	2653	c.2371G>C	c.(2371-2373)Gcc>Ccc	p.A791P	ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.A791P|ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.A791P	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	791					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						AGAAGGATGGCTACTGTCAGG	0.542													97	115					0	0	1	0	0	G	138394427	C	G	138394427	3	3	54	1	0	0	0	0	1	0	0	0	1168	797	28	5	159	5	ATP6V0A4	7	138394427	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	116636934	138394427	20744236	18	9335										
WRN	7486	broad.mit.edu	37	chr8	30924601	30924601	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tctggttaaacacctcttagGtaaacagctcctgaaagaca	7	10	2	2			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr8:30924601G>T	ENST00000298139.5	+	6	806	c.557G>T	c.(556-558)gGt>gTt	p.G186V		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	186	3'-5' exonuclease.|Interaction with WRNIP1 (By similarity).				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CACCTCTTAGGTAAACAGCTC	0.418			"Mis, N, F, S"			"osteosarcoma, meningioma, others"		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				24	0					2.89027e-11	3.08622e-11	1	1	0	T	30924601	G	T	30924601	3	4	54	1	0	0	0	0	1	0	0	0	17461	1261	44	5	575	5	WRN	8	30924601	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08		30924601	115439421	19	9336										
PLAA	9373	broad.mit.edu	37	chr9	26919455	26919455	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tgcagttaaccaagggtcatCactggtattatatggcaatt	9	7	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr9:26919455C>T	ENST00000397292.3	-	9	1687	c.1270G>A	c.(1270-1272)Gat>Aat	p.D424N	PLAA_ENST00000520641.1_5'UTR|PLAA_ENST00000520884.1_Missense_Mutation_p.D424N	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	424	PFU.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CAAGGGTCATCACTGGTATTA	0.313													34	69					0	0	1	0	0	T	26919455	C	T	26919455	3	4	54	1	0	0	0	0	1	0	0	0	12058	826	29	3	1141	3	PLAA	9	26919455	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		26919455	114293976	20	9337										
TOPORS	10210	broad.mit.edu	37	chr9	32550878	32550878	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	cgcgaaggcgtacccggcgaCttctccgcctaccctccgaa	10	18	1	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr9:32550878C>A	ENST00000360538.2	-	2	208	c.92G>T	c.(91-93)aGt>aTt	p.S31I	TOPORS_ENST00000379858.1_Intron	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	31	E3 ubiquitin-protein ligase activity.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TACCCGGCGACTTCTCCGCCT	0.726													9	13					0.0692343	0.0692343	1	1	0	A	32550878	C	A	32550878	3	1	54	1	0	0	0	0	1	0	0	0	16430	565	20	5	3053	5	TOPORS	9	32550878	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	5631423	32550878	108662553	21	9338										
NAA35	60560	broad.mit.edu	37	chr9	88593281	88593281	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	atggcatccaggcccagaatGatactacaaaaggaggtaat	10	8	0	2			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr9:88593281G>A	ENST00000361671.5	+	11	995	c.862G>A	c.(862-864)Gat>Aat	p.D288N	NAA35_ENST00000376040.1_Missense_Mutation_p.D288N	NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	288					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						GGCCCAGAATGATACTACAAA	0.373													15	22					0	0	1	0	0	A	88593281	G	A	88593281	3	1	54	1	0	0	0	0	1	0	0	0	10170	1290	45	3	900	3	NAA35	9	88593281	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	56042403	88593281	52620150	22	9339										
DDX31	64794	broad.mit.edu	37	chr9	135487643	135487643	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ttggatgaaggactgcagagCtgaaagaaaagagagcgggg	17	4	0	5			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr9:135487643C>T	ENST00000372159.3	-	19	2292		c.e19-1		DDX31_ENST00000372153.1_Splice_Site|DDX31_ENST00000438527.3_Splice_Site	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		GACTGCAGAGCTGAAAGAAAA	0.562													18	16					0	0	1	0	0	T	135487643	C	T	135487643	5	4	54	1	0	0	0	0	0	0	1	0	4379	811	28	3	423	3	DDX31	9	135487643	Splice_Site	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	46894362	135487643	5725788	23	9340										
TUBAL3	79861	broad.mit.edu	37	chr10	5436259	5436259	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	agagttataaggctctaccaCagcagtggagatcctggggg	14	8	1	2			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr10:5436259C>T	ENST00000380419.3	-	4	599	c.562G>A	c.(562-564)Gtg>Atg	p.V188M	TUBAL3_ENST00000479328.1_Missense_Mutation_p.V148M	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	188					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						GGCTCTACCACAGCAGTGGAG	0.517													51	33					0	0	1	0	0	T	5436259	C	T	5436259	3	4	54	1	0	0	0	0	1	0	0	0	16812	478	17	3	782	3	TUBAL3	10	5436259	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		5436259	130098488	24	9341										
CTBP2	1488	broad.mit.edu	37	chr10	126682516	126682516	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gctttctcgtccaccaggccGccacgggctgcgttcacaag	11	16	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr10:126682516G>A	ENST00000309035.6	-	6	2569	c.2439C>T	c.(2437-2439)ggC>ggT	p.G813G	CTBP2_ENST00000337195.5_Silent_p.G273G|CTBP2_ENST00000334808.6_Silent_p.G341G|CTBP2_ENST00000411419.2_Silent_p.G273G|CTBP2_ENST00000531469.1_Silent_p.G273G|CTBP2_ENST00000494626.2_Silent_p.G273G	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	273					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCACCAGGCCGCCACGGGCTG	0.582													4	220					0	0	1	0	0	A	126682516	G	A	126682516	2	1	54	1	0	0	0	0	0	0	0	1	4022	1074	38	1		1	CTBP2	10	126682516	Silent	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	121246257	126682516	8852231	25	9342										
OR51A4	401666	broad.mit.edu	37	chr11	4967462	4967462	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tttttacacaataaacaattGggttcgtcagtggaggtaca	9	6	1	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr11:4967462G>A	ENST00000380373.2	-	1	894	c.869C>T	c.(868-870)cCa>cTa	p.P290L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAAACAATTGGGTTCGTCAG	0.423													10	74					0	0	1	0	0	A	4967462	G	A	4967462	3	1	54	1	0	0	0	0	1	0	0	0	11134	1348	47	3	74	3	OR51A4	11	4967462	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08		4967462	130039054	26	9343										
DHH	50846	broad.mit.edu	37	chr12	49488228	49488228	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ccggcccccggcccggcccgCagctctgggctggcagcgcc	15	21	1	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr12:49488228C>T	ENST00000266991.2	-	1	374	c.68G>A	c.(67-69)tGc>tAc	p.C23Y		NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	23					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						gcccggcccgcAGCTCTGGGC	0.672													10	11					0	0	1	0	0	T	49488228	C	T	49488228	3	4	54	1	0	0	0	0	1	0	0	0	4511	710	25	3	1134	3	DHH	12	49488228	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		49488228	84363667	27	9344										
RNASE2	6036	broad.mit.edu	37	chr14	21423973	21423973	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	cccaaatttgtctgcttcttCtgttggggcttctggctgtg	11	10	4	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr14:21423973C>T	ENST00000304625.2	+	2	133	c.43C>T	c.(43-45)Ctg>Ttg	p.L15L		NM_002934.2	NP_002925.1	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	15					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	17	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		TCTGCTTCTTCTGTTGGGGCT	0.463													31	111					0	0	1	0	0	T	21423973	C	T	21423973	2	4	54	1	0	0	0	0	0	0	0	1	13455	912	32	3		3	RNASE2	14	21423973	Silent	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		21423973	85925567	28	9345										
HCFC1R1	54985	broad.mit.edu	37	chr16	3073909	3073909	+	Frame_Shift_Del	DEL	G	G	-													0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gaggcgctgggcccctccctGggggcctcgctgcaagggct							TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr16:3073909delG	ENST00000248089.3	-	1	338	c.34delC	c.(34-36)agfs	p.Q12fs	HCFC1R1_ENST00000354679.3_Frame_Shift_Del_p.Q12fs|HCFC1R1_ENST00000396916.1_Frame_Shift_Del_p.Q12fs|HCFC1R1_ENST00000572355.1_Intron|HCFC1R1_ENST00000574980.1_Frame_Shift_Del_p.Q12fs|HCFC1R1_ENST00000574151.1_Frame_Shift_Del_p.Q12fs	NM_017885.2	NP_060355.1	Q9NWW0	HPIP_HUMAN	host cell factor C1 regulator 1 (XPO1 dependent)	12						cytoplasm|nucleus				breast(1)|large_intestine(1)|upper_aerodigestive_tract(1)	3						GCCCCTCCCTGGGGGCCTCGC	0.711													2	4	---	---	---	---						-	3073909	G	-	3073909	7	5	54	1	0	1	0	1	0	0	0	0	7032	1357	47	0	398	0	HCFC1R1	16	3073909	Frame_Shift_Del	DEL	G	TCGA-NG-A4VU-01A-11D-A28R-08		3073909	87280844	29	9346										
DVL2	1856	broad.mit.edu	37	chr17	7129436	7129436	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gctcggagattaggggcaccCccagttgagcctctggatgg	15	11	1	2			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr17:7129436C>G	ENST00000005340.5	-	15	2241	c.1959G>C	c.(1957-1959)ggG>ggC	p.G653G	DVL2_ENST00000575458.1_Silent_p.G647G	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	653					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						TAGGGGCACCCCCAGTTGAGC	0.672													38	5					0	0	1	0	0	G	7129436	C	G	7129436	2	3	54	1	0	0	0	0	0	0	0	1	4862	610	22	5		5	DVL2	17	7129436	Silent	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		7129436	74065774	30	9347										
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr17:7578406C>T	ENST00000420246.2	-	5	656	c.524G>A	c.(523-525)cGc>cAc	p.R175H	TP53_ENST00000413465.2_Missense_Mutation_p.R175H|TP53_ENST00000359597.4_Missense_Mutation_p.R175H|TP53_ENST00000455263.2_Missense_Mutation_p.R175H|TP53_ENST00000445888.2_Missense_Mutation_p.R175H|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000269305.4_Missense_Mutation_p.R175H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	175	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(847)|p.R43H(36)|p.R82H(36)|p.R175L(19)|p.0?(8)|p.R175P(6)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*5(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(AU565_BREAST)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(HCC1395_BREAST)|R175H(HUCCT1_BILIARY_TRACT)|R175H(KLE_ENDOMETRIUM)|R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(LS123_LARGE_INTESTINE)|R175H(NCIH196_LUNG)|R175H(RKN_OVARY)|R175H(SKBR3_BREAST)|R175H(SKUT1_SOFT_TISSUE)|R175H(TYKNU_OVARY)	111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			45	1					0	0	1	0	0	T	7578406	C	T	7578406	3	4	54	1	0	0	0	0	1	0	0	0	16441	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	448970	7578406	73616804	31	9348										
PTRF	284119	broad.mit.edu	37	chr17	40557062	40557062	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gtgcccagcttgttcatgcgCttctccagggtgtgccgcgt	13	13	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr17:40557062C>T	ENST00000357037.5	-	2	1235	c.816G>A	c.(814-816)aaG>aaA	p.K272K		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	272					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		TGTTCATGCGCTTCTCCAGGG	0.617													27	31					0	0	1	0	0	T	40557062	C	T	40557062	2	4	54	1	0	0	0	0	0	0	0	1	12866	796	28	3		3	PTRF	17	40557062	Silent	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	32978656	40557062	40638148	32	9349										
PALM	5064	broad.mit.edu	37	chr19	740396	740396	+	Frame_Shift_Del	DEL	G	G	-													0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tggagaaggacaaggtgacaGgggagaccagggtgctgtcc							TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:740396delG	ENST00000338448.5	+	8	593	c.547delG	c.(547-549)ggfs	p.G183fs	PALM_ENST00000264560.7_Intron|PALM_ENST00000606643.1_Intron	NM_002579.2	NP_002570.2	O75781	PALM_HUMAN	paralemmin	183					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		CAAGGTGACAGGGGAGACCAG	0.652													2	4	---	---	---	---						-	740396	G	-	740396	7	5	54	1	0	1	0	1	0	0	0	0	11454	1000	35	0	577	0	PALM	19	740396	Frame_Shift_Del	DEL	G	TCGA-NG-A4VU-01A-11D-A28R-08		740396	58388587	33	9350										
RFX1	5989	broad.mit.edu	37	chr19	14090342	14090342	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gggcgcttgtggagtggcctGgaccacagatctctgggagg	18	9	1	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:14090342G>A	ENST00000254325.4	-	7	985	c.751C>T	c.(751-753)Cag>Tag	p.Q251*		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	251					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GGAGTGGCCTGGACCACAGAT	0.622													97	74					0	0	1	0	0	A	14090342	G	A	14090342	4	1	54	1	0	0	0	0	0	1	0	0	13313	1357	47	3	2248	3	RFX1	19	14090342	Nonsense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	13349946	14090342	45038641	34	9351										
PEPD	5184	broad.mit.edu	37	chr19	34003603	34003603	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	agcagggttcttccgcagccGctcacacaggcgctgccggt	13	15	2	0	rs61734503		TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:34003603G>C	ENST00000244137.6	-	2	130	c.97C>G	c.(97-99)Cgg>Ggg	p.R33G	PEPD_ENST00000436370.3_Missense_Mutation_p.R33G|PEPD_ENST00000397032.4_Missense_Mutation_p.R33G	NM_000285.3	NP_000276.2	P12955	PEPD_HUMAN	peptidase D	33					cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	17	Esophageal squamous(110;0.137)					TTCCGCAGCCGCTCACACAGG	0.647													12	48					0	0	1	0	0	C	34003603	G	C	34003603	3	2	54	1	0	0	0	0	1	0	0	0	11774	1086	38	5	1440	5	PEPD	19	34003603	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	19913261	34003603	25125380	35	9352										
ADCK4	79934	broad.mit.edu	37	chr19	41216006	41216006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	catggacttcttagccatctCggccagtactcctagcccca	7	16	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:41216006C>T	ENST00000324464.3	-	5	626	c.325G>A	c.(325-327)Gag>Aag	p.E109K	ADCK4_ENST00000450541.1_Missense_Mutation_p.E109K|ADCK4_ENST00000243583.6_Missense_Mutation_p.E109K	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	109						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			TTAGCCATCTCGGCCAGTACT	0.597													40	44					0	0	1	0	0	T	41216006	C	T	41216006	3	4	54	1	0	0	0	0	1	0	0	0	289	893	31	1	1353	1	ADCK4	19	41216006	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	7212403	41216006	17912977	36	9353										
CEACAM21	90273	broad.mit.edu	37	chr19	42091840	42091840	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ggagcagcagcccccagcctCcacccccggtgagtgtccct	11	19	0	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:42091840C>G	ENST00000407170.2	+	6	1271	c.458C>G	c.(457-459)tCc>tGc	p.S153C	CEACAM21_ENST00000482870.2_3'UTR|CEACAM21_ENST00000187608.9_Missense_Mutation_p.S280C|CEACAM21_ENST00000401445.2_Missense_Mutation_p.S281C			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	281	Ig-like C2-type.					integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						CCCCCAGCCTCCACCCCCGGT	0.572													31	43					0	0	1	0	0	G	42091840	C	G	42091840	3	3	54	1	0	0	0	0	1	0	0	0	3214	855	30	2	860	2	CEACAM21	19	42091840	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	875834	42091840	17037143	37	9354										
ARHGAP35	2909	broad.mit.edu	37	chr19	47424519	47424519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ttgttttttattcagccaaaCgtaaggcctctttggctatg	8	8	2	0			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:47424519C>T	ENST00000404338.3	+	1	2587	c.2587C>T	c.(2587-2589)Cgt>Tgt	p.R863C		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	863					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										TTCAGCCAAACGTAAGGCCTC	0.438													23	36					0	0	1	0	0	T	47424519	C	T	47424519	3	4	54	1	0	0	0	0	1	0	0	0	6835	536	19	1	2589	1	ARHGAP35	19	47424519	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	5332679	47424519	11704464	38	9355										
PPP2R1A	5518	broad.mit.edu	37	chr19	52723052	52723052	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ctgccattgtggagctggctGaggacgccaagtggcgggtg	18	9	0	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:52723052G>A	ENST00000322088.6	+	10	1295	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.E358K|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.E234K	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	413	PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GGAGCTGGCTGAGGACGCCAA	0.627			Mis		clear cell ovarian carcinoma								20	33					0	0	1	0	0	A	52723052	G	A	52723052	3	1	54	1	0	0	0	0	1	0	0	0	12430	1291	45	3	1275	3	PPP2R1A	19	52723052	Missense_Mutation	SNP	G	TCGA-NG-A4VU-01A-11D-A28R-08	5298533	52723052	6405931	39	9356										
ZNF324	25799	broad.mit.edu	37	chr19	58982178	58982178	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	ataccccacctgggatgactActagcgtcttccctgttgcc	8	15	1	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr19:58982178A>G	ENST00000536459.2	+	4	1028	c.319A>G	c.(319-321)Act>Gct	p.T107A	ZNF324_ENST00000196482.3_Missense_Mutation_p.T107A			O75467	Z324A_HUMAN	zinc finger protein 324	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TGGGATGACTACTAGCGTCTT	0.552													5	122					0	0	1	0	0	G	58982178	A	G	58982178	3	3	54	1	0	0	0	0	1	0	0	0	17900	391	14	4	329	4	ZNF324	19	58982178	Missense_Mutation	SNP	A	TCGA-NG-A4VU-01A-11D-A28R-08	6259126	58982178	146805	40	9357										
AP1B1	162	broad.mit.edu	37	chr22	29754889	29754889	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tcgcacaggtactctgtgatCttgtcaacgcggatgcagcc	11	12	3	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr22:29754889C>T	ENST00000357586.2	-	5	537	c.351G>A	c.(349-351)aaG>aaA	p.K117K	AP1B1_ENST00000415447.1_Silent_p.K117K|AP1B1_ENST00000405198.1_Silent_p.K117K|AP1B1_ENST00000356015.2_Silent_p.K117K|AP1B1_ENST00000432560.2_Silent_p.K117K|AP1B1_ENST00000317368.7_Silent_p.K117K|AP1B1_ENST00000402502.1_Silent_p.K117K	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	117					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACTCTGTGATCTTGTCAACGC	0.627													8	13					0	0	1	0	0	T	29754889	C	T	29754889	2	4	54	1	0	0	0	0	0	0	0	1	727	912	32	3		3	AP1B1	22	29754889	Silent	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		29754889	21549677	41	9358										
EIF3D	8664	broad.mit.edu	37	chr22	36919950	36919950	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	tgaaaatctcacctctctttCtgtttggcactcttaggcag	7	11	4	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chr22:36919950C>T	ENST00000216190.8	-	5	754	c.384G>A	c.(382-384)caG>caA	p.Q128Q	EIF3D_ENST00000541106.1_Silent_p.Q79Q|EIF3D_ENST00000405442.1_Silent_p.Q128Q	NM_003753.3	NP_003744.1	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3, subunit D	128						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			cervix(1)|endometrium(2)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	15						ACCTCTCTTTCTGTTTGGCAC	0.502													35	28					0	0	1	0	0	T	36919950	C	T	36919950	2	4	54	1	0	0	0	0	0	0	0	1	5042	912	32	3		3	EIF3D	22	36919950	Silent	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08	7165061	36919950	14384616	42	9359										
MAGEC2	51438	broad.mit.edu	37	chrX	141291113	141291113	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186046511627907	8	0.401168445648911	2.09090909090909	2.09090909090909	2.09090909090909	0.131934731934732	0.651583710407241	0	gttctcgggcatgccctcatCatcactaccctcatcggtga	8	15	5	1			TCGA-NG-A4VU-01A-11D-A28R-08	TCGA-NG-A4VU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13a72df3-4f78-47e7-ba26-f59dd23f3e86	2551e882-f53e-42d6-84a3-ed52888aacea	g.chrX:141291113C>G	ENST00000247452.3	-	3	1008	c.661G>C	c.(661-663)Gat>Cat	p.D221H		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	221	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCCCTCATCATCACTACCC	0.502										HNSCC(46;0.14)			51	8					0	0	1	0	0	G	141291113	C	G	141291113	3	3	54	1	0	0	0	0	1	0	0	0	9230	826	29	2	464	2	MAGEC2	23	141291113	Missense_Mutation	SNP	C	TCGA-NG-A4VU-01A-11D-A28R-08		141291113	13979447	43	9360										
MYOM3	127294	broad.mit.edu	37	chr1	24390563	24390563	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	acccatcgccagctcctaccGtcacccgtgaggtccaatat	7	17	1	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:24390563G>A	ENST00000330966.7	-	30	3792	c.3631_splice	c.e30+1	p.D1210_splice	RP11-293P20.2_ENST00000439239.2_RNA|MYOM3_ENST00000374434.3_Splice_Site_p.D1207_splice|MYOM3_ENST00000338909.5_Splice_Site_p.D100_splice			Q5VTT5	MYOM3_HUMAN	myomesin 3	1207										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		AGCTCCTACCGTCACCCGTGA	0.522													12	68					0	0	1	0	0	A	24390563	G	A	24390563	5	1	55	1	0	0	0	0	0	0	1	0	10140	1159	40	1	724	1	MYOM3	1	24390563	Splice_Site	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		24390563	224860058	1	9361										
ZBTB7B	51043	broad.mit.edu	37	chr1	154988215	154988215	+	Missense_Mutation	SNP	A	A	G													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gatcatccatggggcaggcaAactgcctcgccacatgagga							TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:154988215A>G	ENST00000368426.3	+	3	1216	c.1079A>G	c.(1078-1080)aAa>aGa	p.K360R	ZBTB7B_ENST00000535420.1_Missense_Mutation_p.K360R|ZBTB7B_ENST00000292176.2_Missense_Mutation_p.K360R|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.K394R	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	360					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGGCAGGCAAACTGCCTCGC	0.632													17	117					0	0	1	0	0	G	154988215	A	G	154988215	3	3	55	1	0	0	0	0	1	0	0	0	17612	14	1	4	1081	4	ZBTB7B	1	154988215	Missense_Mutation	SNP	A	TCGA-NG-A4VW-01A-11D-A28R-08	130597652	154988215	94262406	2	9362	29	2								
ZBTB7B	51043	broad.mit.edu	37	chr1	154988223	154988223	+	Missense_Mutation	SNP	C	C	T													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	atggggcaggcaaactgcctCgccacatgaggacccacaca							TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:154988223C>T	ENST00000368426.3	+	3	1224	c.1087C>T	c.(1087-1089)Cgc>Tgc	p.R363C	ZBTB7B_ENST00000535420.1_Missense_Mutation_p.R363C|ZBTB7B_ENST00000292176.2_Missense_Mutation_p.R363C|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.R397C	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	363					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CAAACTGCCTCGCCACATGAG	0.637													69	72					0	0	1	0	0	T	154988223	C	T	154988223	3	4	55	1	0	0	0	0	1	0	0	0	17612	884	31	1	1089	1	ZBTB7B	1	154988223	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	8	154988223	94262398	3	9363	29	2								
C1orf112	55732	broad.mit.edu	37	chr1	169821955	169821955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	atgcaaaaagagctcgtcagGagttcccctgggaagaagag	13	8	1	3			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:169821955G>A	ENST00000286031.6	+	24	3089	c.2389G>A	c.(2389-2391)Gag>Aag	p.E797K	SCYL3_ENST00000367772.4_3'UTR|C1orf112_ENST00000498289.1_3'UTR|C1orf112_ENST00000359326.4_Missense_Mutation_p.E797K	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	797										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGCTCGTCAGGAGTTCCCCTG	0.443													26	172					0	0	1	0	0	A	169821955	G	A	169821955	3	1	55	1	0	0	0	0	1	0	0	0	1998	1175	41	3	2475	3	C1orf112	1	169821955	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	14833732	169821955	79428666	4	9364										
GLRX2	51022	broad.mit.edu	37	chr1	193070293	193070293	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ggatctggttcacaggcgccGtcgctaaattctccaaagat	10	11	3	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:193070293G>T	ENST00000367440.3	-	2	639	c.164C>A	c.(163-165)aCg>aAg	p.T55K	GLRX2_ENST00000367439.3_Missense_Mutation_p.T54K|GLRX2_ENST00000472197.1_5'UTR	NM_001243399.1|NM_016066.4	NP_001230328.1|NP_057150.2	Q9NS18	GLRX2_HUMAN	glutaredoxin 2	54					apoptosis|cell differentiation|cell redox homeostasis|DNA protection|electron transport chain|glutathione metabolic process|protein thiol-disulfide exchange|regulation of signal transduction|regulation of transcription, DNA-dependent|response to hydrogen peroxide|response to organic substance|response to redox state|response to temperature stimulus|transport	mitochondrion|nucleus	2 iron, 2 sulfur cluster binding|arsenate reductase (glutaredoxin) activity|electron carrier activity|glutathione disulfide oxidoreductase activity|metal ion binding|protein disulfide oxidoreductase activity			breast(1)|large_intestine(1)|lung(3)	5					Glutathione(DB00143)	CACAGGCGCCGTCGCTAAATT	0.343													6	50					3.59834e-05	3.64696e-05	1	1	0	T	193070293	G	T	193070293	3	4	55	1	0	0	0	0	1	0	0	0	6501	1145	40	5	345	5	GLRX2	1	193070293	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	23248338	193070293	56180328	5	9365										
C1orf106	55765	broad.mit.edu	37	chr1	200880764	200880764	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gacgtctccagcatctcccaCcccacttcgccgggcagcag	9	19	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:200880764C>A	ENST00000367342.4	+	9	1598	c.1398C>A	c.(1396-1398)caC>caA	p.H466Q	C1orf106_ENST00000413687.2_Missense_Mutation_p.H381Q	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	466										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GCATCTCCCACCCCACTTCGC	0.677													30	263					2.25844e-05	2.32031e-05	1	1	0	A	200880764	C	A	200880764	3	1	55	1	0	0	0	0	1	0	0	0	1993	506	18	5	1432	5	C1orf106	1	200880764	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	7810471	200880764	48369857	6	9366										
CR1	1378	broad.mit.edu	37	chr1	207790017	207790017	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	aaagaaatatcttacgcatgCgacacccacccagacagagg	8	12	1	3	rs55775404		TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr1:207790017C>T	ENST00000367049.4	+	41	6759	c.6759C>T	c.(6757-6759)tgC>tgT	p.C2253C	CR1_ENST00000367051.1_Silent_p.C1803C|CR1_ENST00000367052.1_Silent_p.C1803C|CR1_ENST00000367053.1_Silent_p.C1803C|CR1_ENST00000400960.2_Silent_p.C1803C	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1803					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTACGCATGCGACACCCACC	0.498													82	139					0	0	1	0	0	T	207790017	C	T	207790017	2	4	55	1	0	0	0	0	0	0	0	1	3863	776	27	1		1	CR1	1	207790017	Silent	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	6909253	207790017	41460604	7	9367										
EML4	27436	broad.mit.edu	37	chr2	42522396	42522396	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	acaagaaaacagggaattttTggggtaagaatcagattgtt	11	3	1	3			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr2:42522396T>G	ENST00000318522.5	+	12	1612	c.1350T>G	c.(1348-1350)ttT>ttG	p.F450L	EML4_ENST00000402711.2_Missense_Mutation_p.F392L|EML4_ENST00000401738.3_Missense_Mutation_p.F461L	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	450					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						AGGGAATTTTTGGGGTAAGAA	0.328			T	ALK	NSCLC								10	54					0	0	1	0	0	G	42522396	T	G	42522396	3	3	55	1	0	0	0	0	1	0	0	0	5127	1809	63	4	1396	4	EML4	2	42522396	Missense_Mutation	SNP	T	TCGA-NG-A4VW-01A-11D-A28R-08		42522396	200676977	8	9368										
CNGA3	1261	broad.mit.edu	37	chr2	98999903	98999903	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ccagcaacaacacggaggagGagtaagtacccacacaccca	9	14	0	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr2:98999903G>A	ENST00000393504.1	+	5	865	c.449_splice	c.e5+1	p.E150_splice	CNGA3_ENST00000436404.2_Intron|CNGA3_ENST00000409937.1_Splice_Site_p.E154_splice|CNGA3_ENST00000272602.2_Splice_Site_p.E150_splice	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	150					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						CACGGAGGAGGAGTAAGTACC	0.592													19	75					0	0	1	0	0	A	98999903	G	A	98999903	5	1	55	1	0	0	0	0	0	0	1	0	3621	1188	41	3	462	3	CNGA3	2	98999903	Splice_Site	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	56477507	98999903	144199470	9	9369										
WNT10A	80326	broad.mit.edu	37	chr2	219747080	219747080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	acaccaattcagggaccagcGctggaactgctcaagcctgg	11	13	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr2:219747080G>A	ENST00000258411.3	+	2	944	c.311G>A	c.(310-312)cGc>cAc	p.R104H		NM_025216.2	NP_079492.2	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family, member 10A	104					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|cervix(1)|endometrium(2)|lung(6)|skin(2)	12		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGGACCAGCGCTGGAACTGC	0.597													16	112					0	0	1	0	0	A	219747080	G	A	219747080	3	1	55	1	0	0	0	0	1	0	0	0	17441	1087	38	1	317	1	WNT10A	2	219747080	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	120747177	219747080	23452293	10	9370										
DNAH1	25981	broad.mit.edu	37	chr3	52395770	52395770	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	atcaccaccatccagaaggcGcagcagcagcgggtgagccc	12	15	1	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr3:52395770G>A	ENST00000420323.2	+	30	5229	c.4968G>A	c.(4966-4968)gcG>gcA	p.A1656A	DNAH1_ENST00000466628.1_Intron	NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1656	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCCAGAAGGCGCAGCAGCAGC	0.632													3	24					0	0	1	0	0	A	52395770	G	A	52395770	2	1	55	1	0	0	0	0	0	0	0	1	4625	1074	38	1		1	DNAH1	3	52395770	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		52395770	145626660	11	9371										
TMPRSS7	344805	broad.mit.edu	37	chr3	111797605	111797605	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gcagataataaaggctccctCgttctgcagcaagcggaggt	12	10	1	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr3:111797605C>T	ENST00000452346.2	+	17	2244	c.2241C>T	c.(2239-2241)ctC>ctT	p.L747L	TMPRSS7_ENST00000419127.1_Silent_p.L621L			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	747	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AAGGCTCCCTCGTTCTGCAGC	0.443													16	51					0	0	1	0	0	T	111797605	C	T	111797605	2	4	55	1	0	0	0	0	0	0	0	1	16311	871	31	1		1	TMPRSS7	3	111797605	Silent	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	59401835	111797605	86224825	12	9372										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"colorectal, gastric, gliobastoma, breast"					HNSCC(19;0.045)|TSP Lung(28;0.18)			7	28					0	0	1	0	0	A	178936091	G	A	178936091	3	1	55	1	0	0	0	0	1	0	0	0	11960	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	67138486	178936091	19086339	13	9373										
C4orf40	401137	broad.mit.edu	37	chr4	71021774	71021774	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	atttttctttattttagagaCggttccccttcattggtgag	8	7	2	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr4:71021774C>T	ENST00000344526.5	+	2	244	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	C4orf40_ENST00000502441.2_3'UTR|C4orf40_ENST00000502294.1_Missense_Mutation_p.R19W	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	19						extracellular region		p.R19W(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						ATTTTAGAGACGGTTCCCCTT	0.259													6	27					0	0	1	0	0	T	71021774	C	T	71021774	3	4	55	1	0	0	0	0	1	0	0	0	2284	527	19	1	61	1	C4orf40	4	71021774	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08		71021774	120132502	14	9374										
RXFP1	59350	broad.mit.edu	37	chr4	159573042	159573042	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tataactacagacaaagaaaAtctatggacagcaaaggtca	7	7	2	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr4:159573042A>C	ENST00000307765.5	+	18	2360	c.2109A>C	c.(2107-2109)aaA>aaC	p.K703N	RXFP1_ENST00000343542.5_Missense_Mutation_p.K655N|RXFP1_ENST00000448688.2_Missense_Mutation_p.K598N|RXFP1_ENST00000460056.2_Missense_Mutation_p.K622N|RXFP1_ENST00000470033.1_Missense_Mutation_p.K670N	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	703						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GACAAAGAAAATCTATGGACA	0.423													9	62					0	0	1	0	0	C	159573042	A	C	159573042	3	2	55	1	0	0	0	0	1	0	0	0	13810	98	4	4	2179	4	RXFP1	4	159573042	Missense_Mutation	SNP	A	TCGA-NG-A4VW-01A-11D-A28R-08	88551268	159573042	31581234	15	9375										
NDUFAF2	91942	broad.mit.edu	37	chr5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ttacccctactgcgggtcccGctgctggcagcgctggaaac	12	15	0	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632													3	28					0	0	1	0	0	A	60241050	G	A	60241050	1	1	55	1	0	0	0	0	0	0	0	0	10321	1102	38	1		1	NDUFAF2	5	60241050	Translation_Start_Site	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		60241050	120674210	16	9376										
PCDHB11	0	broad.mit.edu	37	chr5	140581324	140581324	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tcggccaccgccacgctgcaAgtgctcctggtggacggctt	13	15	0	0	rs140763995	byFrequency	TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr5:140581324A>C	ENST00000354757.3	+	1	1977	c.1977A>C	c.(1975-1977)caA>caC	p.Q659H	PCDHB11_ENST00000536699.1_Missense_Mutation_p.Q294H	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		659	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.Q659H(1)		NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACGCTGCAAGTGCTCCTGG	0.711													5	123					0	0	1	0	0	C	140581324	A	C	140581324	3	2	55	1	0	0	0	0	1	0	0	0	11582	69	3	4	1979	4	PCDHB11	5	140581324	Missense_Mutation	SNP	A	TCGA-NG-A4VW-01A-11D-A28R-08	80340274	140581324	40333936	17	9377										
TAF7	6879	broad.mit.edu	37	chr5	140699511	140699511	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ccttgaggttgacatgaccaGactgtactgcccttctcaca	8	13	1	4			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr5:140699511G>A	ENST00000313368.5	-	1	819	c.101C>T	c.(100-102)tCt>tTt	p.S34F		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	34					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACATGACCAGACTGTACTGC	0.468													17	85					0	0	1	0	0	A	140699511	G	A	140699511	3	1	55	1	0	0	0	0	1	0	0	0	15588	942	33	3	952	3	TAF7	5	140699511	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	118187	140699511	40215749	18	9378										
TNIP1	10318	broad.mit.edu	37	chr5	150436454	150436454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cctcggcacacacactcagcGtggtctccaggcgctgcagg	12	16	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr5:150436454G>A	ENST00000389378.2	-	6	1088	c.500C>T	c.(499-501)aCg>aTg	p.T167M	TNIP1_ENST00000522226.1_Missense_Mutation_p.T167M|TNIP1_ENST00000520931.1_Missense_Mutation_p.T114M|TNIP1_ENST00000524280.1_Missense_Mutation_p.T167M|TNIP1_ENST00000315050.7_Missense_Mutation_p.T167M|TNIP1_ENST00000523338.1_Missense_Mutation_p.T167M|TNIP1_ENST00000523200.1_Missense_Mutation_p.T167M|TNIP1_ENST00000521591.1_Missense_Mutation_p.T167M|TNIP1_ENST00000518977.1_Missense_Mutation_p.T167M	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	167	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACACTCAGCGTGGTCTCCAG	0.672													14	60					0	0	1	0	0	A	150436454	G	A	150436454	3	1	55	1	0	0	0	0	1	0	0	0	16373	1145	40	1	1462	1	TNIP1	5	150436454	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	9736943	150436454	30478806	19	9379										
F13A1	2162	broad.mit.edu	37	chr6	6266846	6266847	+	Frame_Shift_Ins	INS	-	-	C													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tttctgggtttcgactggttINScgaagtacgccatagggagt							TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr6:6266846_6266847insC	ENST00000264870.3	-	4	780_781	c.515_516insG	c.(514-516)cacfs	p.H172fs		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	172					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.R172Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TTCGACTGGTTCGAAGTACGCC	0.455													20	110	---	---	---	---						C	6266847	-	C	6266846	7	5	55	1	0	1	1	0	0	0	0	0	5368	1770	62	0	1730	0	F13A1	6	6266846	Frame_Shift_Ins	INS	-	TCGA-NG-A4VW-01A-11D-A28R-08		6266846	164848221	20	9380										
BCLAF1	9774	broad.mit.edu	37	chr6	136599647	136599647	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cggcgagatctgcttctggaTctttgagaagaaacggatct	12	8	4	3			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr6:136599647T>G	ENST00000531224.1	-	4	624	c.372A>C	c.(370-372)agA>agC	p.R124S	BCLAF1_ENST00000530767.1_Missense_Mutation_p.R124S|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R122S|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R124S|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R122S|BCLAF1_ENST00000392348.2_Missense_Mutation_p.R122S	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	124					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGCTTCTGGATCTTTGAGAAG	0.448													14	210					0	0	1	0	0	G	136599647	T	G	136599647	3	3	55	1	0	0	0	0	1	0	0	0	1381	1432	50	4	2430	4	BCLAF1	6	136599647	Missense_Mutation	SNP	T	TCGA-NG-A4VW-01A-11D-A28R-08	130332801	136599647	34515420	21	9381										
MAD1L1	8379	broad.mit.edu	37	chr7	2265126	2265126	+	Frame_Shift_Del	DEL	C	C	-													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ctcagctccatctgcattttCtcccgctccacctggatgag							TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr7:2265126delC	ENST00000406869.1	-	4	767	c.210delG	c.(208-210)gafs	p.E70fs	MAD1L1_ENST00000399654.2_Frame_Shift_Del_p.E70fs|MAD1L1_ENST00000265854.7_Frame_Shift_Del_p.E70fs|MAD1L1_ENST00000402746.1_Intron			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	70					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCTGCATTTTCTCCCGCTCCA	0.577													13	72	---	---	---	---						-	2265126	C	-	2265126	7	5	55	1	0	1	0	1	0	0	0	0	9192	912	32	0	2010	0	MAD1L1	7	2265126	Frame_Shift_Del	DEL	C	TCGA-NG-A4VW-01A-11D-A28R-08		2265126	156873537	22	9382										
HECW1	23072	broad.mit.edu	37	chr7	43477687	43477687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gagccgccccatcatcaagcGcttcttgggaaagctgtcga	11	13	3	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr7:43477687G>A	ENST00000395891.1	+	9	1492	c.887G>A	c.(886-888)cGc>cAc	p.R296H	HECW1_ENST00000453890.1_Missense_Mutation_p.R296H|HECW1_ENST00000471043.1_3'UTR	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	296	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ATCATCAAGCGCTTCTTGGGA	0.493													11	73					0	0	1	0	0	A	43477687	G	A	43477687	3	1	55	1	0	0	0	0	1	0	0	0	7082	1087	38	1	913	1	HECW1	7	43477687	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	41212561	43477687	115660976	23	9383										
ABCB1	5243	broad.mit.edu	37	chr7	87148697	87148697	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	caccaagtaggctccaaaccGgaaacatccagcataggaaa	8	12	0	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr7:87148697G>A	ENST00000265724.3	-	24	3289	c.2872C>T	c.(2872-2874)Cgg>Tgg	p.R958W	ABCB1_ENST00000543898.1_Missense_Mutation_p.R894W|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	958	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCTCCAAACCGGAAACATCCA	0.378													14	49					0	0	1	0	0	A	87148697	G	A	87148697	3	1	55	1	0	0	0	0	1	0	0	0	40	1115	39	1	994	1	ABCB1	7	87148697	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	43671010	87148697	71989966	24	9384										
GIGYF1	64599	broad.mit.edu	37	chr7	100281657	100281657	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	acgcacctggggggtttgagCgcctggagctgctgcaggaa	17	10	0	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr7:100281657C>T	ENST00000275732.5	-	15	3063	c.1854G>A	c.(1852-1854)gcG>gcA	p.A618A		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	618										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGGGTTTGAGCGCCTGGAGCT	0.657													5	30					0	0	1	0	0	T	100281657	C	T	100281657	2	4	55	1	0	0	0	0	0	0	0	1	6418	755	27	1		1	GIGYF1	7	100281657	Silent	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	13132960	100281657	58857006	25	9385										
CUX1	1523	broad.mit.edu	37	chr7	101747648	101747648	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	aagcacttaaagagaaaatcCgagaatatgaacagacactg	8	7	0	4			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr7:101747648C>T	ENST00000360264.3	+	6	492	c.472C>T	c.(472-474)Cga>Tga	p.R158*	CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000556210.1_Nonsense_Mutation_p.R147*|CUX1_ENST00000547394.2_Nonsense_Mutation_p.R142*|CUX1_ENST00000546411.2_Nonsense_Mutation_p.R147*|CUX1_ENST00000393824.3_Nonsense_Mutation_p.R121*|CUX1_ENST00000550008.2_Nonsense_Mutation_p.R147*|CUX1_ENST00000437600.4_Nonsense_Mutation_p.R158*|CUX1_ENST00000292535.7_Nonsense_Mutation_p.R147*|CUX1_ENST00000549414.2_Nonsense_Mutation_p.R147*|CUX1_ENST00000292538.4_Nonsense_Mutation_p.R158*|CUX1_ENST00000425244.2_Nonsense_Mutation_p.R112*	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	147					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R147*(1)|p.R158*(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AGAGAAAATCCGAGAATATGA	0.388													33	130					0	0	1	0	0	T	101747648	C	T	101747648	4	4	55	1	0	0	0	0	0	1	0	0	4087	644	23	1	528	1	CUX1	7	101747648	Nonsense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	1465991	101747648	57391015	26	9386										
PCSK5	5125	broad.mit.edu	37	chr9	78790136	78790136	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cagaatggaatggaatggaaTgaaatggaatggaatgaaat	13	1	0	3	rs62556589		TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr9:78790136T>C	ENST00000376767.3	+	14	2503	c.1991T>C	c.(1990-1992)aTg>aCg	p.M664T	PCSK5_ENST00000545128.1_Intron|PCSK5_ENST00000376752.4_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						tggaatggaatgaaatggaat	0.423													3	29					0	0	1	0	0	C	78790136	T	C	78790136	3	2	55	1	0	0	0	0	1	0	0	0	11649	1479	51	4		4	PCSK5	9	78790136	Missense_Mutation	SNP	T	TCGA-NG-A4VW-01A-11D-A28R-08		78790136	62423295	27	9387										
TLE1	7088	broad.mit.edu	37	chr9	84207940	84207943	+	Splice_Site	DEL	CAGA	CAGA	-													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	accagttcctgttcactcacCagacagtcgagctgggagac							TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr9:84207940_84207943delCAGA	ENST00000376499.3	-	15	2642_2645	c.1581_splice	c.e15+1	p.CL526_splice		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	526					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						GTTCACTCACCAGACAGTCGAGCT	0.534													10	74	---	---	---	---						-	84207943	CAGA	-	84207940	8	5	55	1	0	1	0	1	0	0	1	0	15997	608	21	0	755	0	TLE1	9	84207940	Splice_Site	DEL	CAGA	TCGA-NG-A4VW-01A-11D-A28R-08	5417804	84207940	57005491	28	9388										
PRPF4	9128	broad.mit.edu	37	chr9	116049072	116049072	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tgtcaacctggcctcttgtgCggctgatggctctgtgaagc	13	11	3	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr9:116049072C>T	ENST00000374199.4	+	9	1297	c.896C>T	c.(895-897)gCg>gTg	p.A299V	PRPF4_ENST00000374198.4_Missense_Mutation_p.A300V			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	300						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						GCCTCTTGTGCGGCTGATGGC	0.468													5	458					0	0	1	0	0	T	116049072	C	T	116049072	3	4	55	1	0	0	0	0	1	0	0	0	12621	768	27	1	933	1	PRPF4	9	116049072	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	31841132	116049072	25164359	29	9389										
NR6A1	2649	broad.mit.edu	37	chr9	127300415	127300415	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cccaatggttccaggtcctcGgctgataacagctggtgaat	11	11	0	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr9:127300415G>A	ENST00000487099.2	-	6	937	c.780C>T	c.(778-780)gcC>gcT	p.A260A	NR6A1_ENST00000416460.2_Silent_p.A255A|NR6A1_ENST00000344523.4_Silent_p.A259A|NR6A1_ENST00000373584.3_Silent_p.A256A	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	260					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						CCAGGTCCTCGGCTGATAACA	0.557													10	58					0	0	1	0	0	A	127300415	G	A	127300415	2	1	55	1	0	0	0	0	0	0	0	1	10684	1103	39	1		1	NR6A1	9	127300415	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	11251343	127300415	13913016	30	9390										
COL5A1	1289	broad.mit.edu	37	chr9	137653812	137653812	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ccaccaggacctccgggagaCgatggagaaagggtaggtat	15	9	0	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr9:137653812C>T	ENST00000371817.3	+	19	2391	c.1977C>T	c.(1975-1977)gaC>gaT	p.D659D		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	659	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTCCGGGAGACGATGGAGAAA	0.597													15	62					0	0	1	0	0	T	137653812	C	T	137653812	2	4	55	1	0	0	0	0	0	0	0	1	3719	535	19	1		1	COL5A1	9	137653812	Silent	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	10353397	137653812	3559619	31	9391										
GRID1	2894	broad.mit.edu	37	chr10	87628820	87628820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gcagagcagggaggagatgcGgtggttgttcctcgtgcatt	17	7	0	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr10:87628820G>A	ENST00000327946.7	-	6	983	c.898C>T	c.(898-900)Cgc>Tgc	p.R300C		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	300						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GAGGAGATGCGGTGGTTGTTC	0.567										Multiple Myeloma(13;0.14)			14	93					0	0	1	0	0	A	87628820	G	A	87628820	3	1	55	1	0	0	0	0	1	0	0	0	6811	1116	39	1	2175	1	GRID1	10	87628820	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		87628820	47905927	32	9392										
PTEN	5728	broad.mit.edu	37	chr10	89653815	89653815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cattattgctatgggatttcCtgcagaaagacttgaaggcg	11	7	0	3			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr10:89653815C>T	ENST00000371953.3	+	2	1470	c.113C>T	c.(112-114)cCt>cTt	p.P38L		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	38	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(8)|p.Y27fs*1(2)|p.P38R(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATGGGATTTCCTGCAGAAAGA	0.289		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			7	55					0	0	1	0	0	T	89653815	C	T	89653815	3	4	55	1	0	0	0	0	1	0	0	0	12786	681	24	3	119	3	PTEN	10	89653815	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	2024995	89653815	45880932	33	9393										
PTEN	5728	broad.mit.edu	37	chr10	89692792	89692792	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gcacaatatccttttgaagaCcataacccaccacagctaga	5	13	0	3			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr10:89692792C>A	ENST00000371953.3	+	5	1633	c.276C>A	c.(274-276)gaC>gaA	p.D92E		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	92	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.Y27fs*1(2)|p.D92E(2)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTTTTGAAGACCATAACCCAC	0.333		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			29	68					1.5548e-18	1.66586e-18	1	1	0	A	89692792	C	A	89692792	3	1	55	1	0	0	0	0	1	0	0	0	12786	506	18	5	294	5	PTEN	10	89692792	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	38977	89692792	45841955	34	9394										
COL17A1	1308	broad.mit.edu	37	chr10	105793951	105793951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	aagagctgtaggagctgcccCgcctgacagatgagctgtgt	14	10	0	4	rs121912771		TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr10:105793951C>T	ENST00000353479.5	-	52	4198	c.3908G>A	c.(3907-3909)cGg>cAg	p.R1303Q	COL17A1_ENST00000369733.3_Missense_Mutation_p.R1221Q	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	1303	Triple-helical region.		R -> Q (in GABEB).		cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGAGCTGCCCCGCCTGACAGA	0.672													9	39					0	0	1	0	0	T	105793951	C	T	105793951	3	4	55	1	0	0	0	0	1	0	0	0	3697	652	23	1	605	1	COL17A1	10	105793951	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	16101159	105793951	29740796	35	9395										
PNLIPRP2	5408	broad.mit.edu	37	chr10	118396277	118396278	+	RNA	INS	-	-	T													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tgactaacagacaaattatgINSgttttttttttccactagag					rs148140777	by1000genomes	TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													5	10	---	---	---	---						T	118396278	-	T	118396277	6	5	55	0	1	1	1	0	0	0	0	0	12198	1363	47	0		0	PNLIPRP2	10	118396277	RNA	INS	-	TCGA-NG-A4VW-01A-11D-A28R-08	12602326	118396277	17138470	36	9396										
SSRP1	6749	broad.mit.edu	37	chr11	57099304	57099304	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	agatgaagccccgctccagcGggtagagcagtcctgagctt	13	12	0	4			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr11:57099304G>A	ENST00000278412.2	-	9	1327	c.1061C>T	c.(1060-1062)cCg>cTg	p.P354L		NM_003146.2	NP_003137.1	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	354					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(4)	23						CCGCTCCAGCGGGTAGAGCAG	0.567													7	38					0	0	1	0	0	A	57099304	G	A	57099304	3	1	55	1	0	0	0	0	1	0	0	0	15249	1116	39	1	1104	1	SSRP1	11	57099304	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		57099304	77907212	37	9397										
DHCR7	1717	broad.mit.edu	37	chr11	71155948	71155948	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gcggttctgtcattggtgacGccatctagactcttggcttt	11	10	4	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr11:71155948G>A	ENST00000355527.3	-	3	327	c.51C>T	c.(49-51)ggC>ggT	p.G17G	DHCR7_ENST00000407721.2_Silent_p.G17G	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	17					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding	p.G17G(2)		endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	CATTGGTGACGCCATCTAGAC	0.502									Smith-Lemli-Opitz syndrome				23	126					0	0	1	0	0	A	71155948	G	A	71155948	2	1	55	1	0	0	0	0	0	0	0	1	4505	1074	38	1		1	DHCR7	11	71155948	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	14056644	71155948	63850568	38	9398										
SPCS2	9789	broad.mit.edu	37	chr11	74687936	74687936	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	acaccttgaagctgaccttcAtcagtgggagaacaaagcag	10	10	2	3			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr11:74687936A>G	ENST00000263672.6	+	5	568	c.529A>G	c.(529-531)Atc>Gtc	p.I177V	SPCS2_ENST00000528265.1_Intron|SPCS2_ENST00000526361.1_Missense_Mutation_p.I38V|SPCS2_ENST00000530257.1_Missense_Mutation_p.I108V	NM_014752.2	NP_055567.2	Q15005	SPCS2_HUMAN	signal peptidase complex subunit 2 homolog (S. cerevisiae)	177					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			breast(1)	1						GCTGACCTTCATCAGTGGGAG	0.443													15	82					0	0	1	0	0	G	74687936	A	G	74687936	3	3	55	1	0	0	0	0	1	0	0	0	15079	217	8	4	547	4	SPCS2	11	74687936	Missense_Mutation	SNP	A	TCGA-NG-A4VW-01A-11D-A28R-08	3531988	74687936	60318580	39	9399										
AQP5	362	broad.mit.edu	37	chr12	50358866	50358866	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ctccctgagcctgagtgagcGtgtggccatcatcaaaggca	12	12	2	3	rs148637740		TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr12:50358866G>A	ENST00000293599.6	+	4	852	c.704G>A	c.(703-705)cGt>cAt	p.R235H		NM_001651.2	NP_001642.1	P55064	AQP5_HUMAN	aquaporin 5	235					carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity			large_intestine(1)|lung(3)	4						CTGAGTGAGCGTGTGGCCATC	0.607													15	76					0	0	1	0	0	A	50358866	G	A	50358866	3	1	55	1	0	0	0	0	1	0	0	0	826	1145	40	1	718	1	AQP5	12	50358866	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		50358866	83493029	40	9400										
KRT6A	3853	broad.mit.edu	37	chr12	52882314	52882314	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ctgctcagcatcagcaatggCggcctgcaggttggcgcact	13	13	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr12:52882314C>T	ENST00000330722.6	-	7	1290	c.1222G>A	c.(1222-1224)Gcc>Acc	p.A408T		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	408	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGCAATGGCGGCCTGCAGG	0.552													13	89					0	0	1	0	0	T	52882314	C	T	52882314	3	4	55	1	0	0	0	0	1	0	0	0	8522	768	27	1	484	1	KRT6A	12	52882314	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	2523448	52882314	80969581	41	9401										
NACA	4666	broad.mit.edu	37	chr12	57109734	57109734	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gatttaggggtgggcatgttGacgaggaccgactggaaagg	18	5	0	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr12:57109734G>A	ENST00000454682.1	-	3	5861	c.5580C>T	c.(5578-5580)gtC>gtT	p.V1860V	NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Silent_p.V707V|NACA_ENST00000356769.3_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000546392.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGCATGTTGACGAGGACCG	0.562			T	BCL6	NHL								16	124					0	0	1	0	0	A	57109734	G	A	57109734	2	1	55	1	0	0	0	0	0	0	0	1	10180	1277	45	3		3	NACA	12	57109734	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	4227420	57109734	76742161	42	9402										
LGR5	8549	broad.mit.edu	37	chr12	71918242	71918242	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gggagcattcactggcctttAcagtcttaaagttctgtaag	10	8	3	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr12:71918242A>G	ENST00000266674.5	+	3	652	c.341A>G	c.(340-342)tAc>tGc	p.Y114C	LGR5_ENST00000536515.1_Missense_Mutation_p.Y114C|LGR5_ENST00000540815.2_Missense_Mutation_p.Y114C			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	114						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						ACTGGCCTTTACAGTCTTAAA	0.418													7	43					0	0	1	0	0	G	71918242	A	G	71918242	3	3	55	1	0	0	0	0	1	0	0	0	8796	391	14	4	351	4	LGR5	12	71918242	Missense_Mutation	SNP	A	TCGA-NG-A4VW-01A-11D-A28R-08	14808508	71918242	61933653	43	9403										
CLLU1OS	574016	broad.mit.edu	37	chr12	92821902	92821902	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ttaaggcattccttaagttcGttgtgccccaatttgttcat	7	9	1	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr12:92821902G>A	ENST00000378487.2	-	1	22	c.21C>T	c.(19-21)aaC>aaT	p.N7N	RP11-693J15.4_ENST00000508671.1_RNA|CLLU1_ENST00000378485.1_Intron|CLLU1OS_ENST00000538965.1_Silent_p.N7N|CLLU1_ENST00000472839.2_Intron	NM_001025232.1	NP_001020403.1	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1 opposite strand	7								p.N7K(1)		large_intestine(1)|lung(7)	8						ccttaagttcgttgtgcccca	0.423													6	36					0	0	1	0	0	A	92821902	G	A	92821902	2	1	55	1	0	0	0	0	0	0	0	1	3564	1136	40	1		1	CLLU1OS	12	92821902	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	20903660	92821902	41029993	44	9404										
RB1	5925	broad.mit.edu	37	chr13	48916759	48916759	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gttatattcaaaagaaaaagGaactgtggggaatctgtatc	10	4	2	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr13:48916759G>T	ENST00000267163.4	+	3	427	c.289G>T	c.(289-291)Gaa>Taa	p.E97*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	97					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(5)|p.E97fs*14(2)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAAGAAAAAGGAACTGTGGGG	0.313		6	"D, Mis, N, F, S"		"retinoblastoma, sarcoma, breast, small cell lung"	"retinoblastoma, sarcoma, breast, small cell lung"			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			9	46					3.09899e-07	3.22811e-07	1	1	0	T	48916759	G	T	48916759	4	4	55	1	0	0	0	0	0	1	0	0	13149	1175	41	2	299	2	RB1	13	48916759	Nonsense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		48916759	66253119	45	9405										
CCDC33	80125	broad.mit.edu	37	chr15	74623364	74623364	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tgctccttctgtatcaggccCagcagccacaggccgctctg	10	16	3	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr15:74623364C>T	ENST00000321288.5	+	16	2197	c.2197C>T	c.(2197-2199)Cag>Tag	p.Q733*	CCDC33_ENST00000558821.1_Nonsense_Mutation_p.Q123*|CCDC33_ENST00000398814.3_Nonsense_Mutation_p.Q530*|CCDC33_ENST00000268082.4_Nonsense_Mutation_p.Q123*			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	733							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GTATCAGGCCCAGCAGCCACA	0.597													7	26					0	0	1	0	0	T	74623364	C	T	74623364	4	4	55	1	0	0	0	0	0	1	0	0	2825	595	21	3	1715	3	CCDC33	15	74623364	Nonsense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08		74623364	27908028	46	9406										
SIN3A	25942	broad.mit.edu	37	chr15	75684736	75684736	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cagcctcaggcagagaatctGgtgcagtcgcataaaaatat	10	9	2	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr15:75684736G>A	ENST00000394947.3	-	15	3012	c.2698C>T	c.(2698-2700)Cag>Tag	p.Q900*	SIN3A_ENST00000360439.4_Nonsense_Mutation_p.Q900*|SIN3A_ENST00000394949.4_Nonsense_Mutation_p.Q900*	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	900					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						CAGAGAATCTGGTGCAGTCGC	0.438													23	74					0	0	1	0	0	A	75684736	G	A	75684736	4	1	55	1	0	0	0	0	0	1	0	0	14379	1357	47	3	1151	3	SIN3A	15	75684736	Nonsense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	1061372	75684736	26846656	47	9407										
SOX8	30812	broad.mit.edu	37	chr16	1033825	1033825	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ccgactacaagtaccagccaCggcgcaggaagagcgccaaa	11	14	0	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr16:1033825C>T	ENST00000293894.3	+	2	635	c.520C>T	c.(520-522)Cgg>Tgg	p.R174W		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	174					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				GTACCAGCCACGGCGCAGGAA	0.677													10	55					0	0	1	0	0	T	1033825	C	T	1033825	3	4	55	1	0	0	0	0	1	0	0	0	15010	527	19	1	526	1	SOX8	16	1033825	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08		1033825	89320928	48	9408										
RPS2	6187	broad.mit.edu	37	chr16	2013186	2013186	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tggccggcacgggtctgcttCtgcactggcataatcttcaa	11	12	4	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr16:2013186C>A	ENST00000529806.1	-	2	435	c.249G>T	c.(247-249)caG>caT	p.Q83H	RPS2_ENST00000343262.4_Missense_Mutation_p.Q113H|RPS2_ENST00000530225.1_Missense_Mutation_p.Q113H|RPS2_ENST00000526522.1_Missense_Mutation_p.Q113H			P15880	RS2_HUMAN	ribosomal protein S2	113					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	fibroblast growth factor 1 binding|fibroblast growth factor 3 binding|RNA binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						GGGTCTGCTTCTGCACTGGCA	0.547													3	5					1	1	1	1	0	A	2013186	C	A	2013186	3	1	55	1	0	0	0	0	1	0	0	0	13682	912	32	2	558	2	RPS2	16	2013186	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	979361	2013186	88341567	49	9409										
PRPF8	10594	broad.mit.edu	37	chr17	1559836	1559837	+	In_Frame_Ins	INS	-	-	TTT													0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ccgatcctttgatgacaataINSttggggaagtccagtaagtg							TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr17:1559836_1559837insTTT	ENST00000572621.1	-	35	5907_5908	c.5642_5643insAAA	c.(5641-5643)aat>aAAAat	p.1880_1881insK	PRPF8_ENST00000304992.6_In_Frame_Ins_p.1880_1881insK			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1880	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGATGACAATATTGGGGAAGTC	0.505													7	77	---	---	---	---						TTT	1559837	-	TTT	1559836	7	5	55	1	0	1	1	0	0	0	0	0	12626	446	16	0	1396	0	PRPF8	17	1559836	In_Frame_Ins	INS	-	TCGA-NG-A4VW-01A-11D-A28R-08		1559836	79635374	50	9410										
WSCD1	23302	broad.mit.edu	37	chr17	6023654	6023654	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ccggactttgtcaacagctaCgcctcgtggtggtcctcgca	11	14	1	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr17:6023654C>T	ENST00000574946.1	+	9	1791	c.1401C>T	c.(1399-1401)taC>taT	p.Y467Y	WSCD1_ENST00000539421.1_Silent_p.Y467Y|WSCD1_ENST00000317744.5_Silent_p.Y467Y|WSCD1_ENST00000573634.1_Silent_p.Y351Y|WSCD1_ENST00000574232.1_Silent_p.Y467Y			Q658N2	WSCD1_HUMAN	WSC domain containing 1	467						integral to membrane	sulfotransferase activity	p.Y467Y(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						TCAACAGCTACGCCTCGTGGT	0.677													42	229					0	0	1	0	0	T	6023654	C	T	6023654	2	4	55	1	0	0	0	0	0	0	0	1	17465	547	19	1		1	WSCD1	17	6023654	Silent	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	4463818	6023654	75171556	51	9411										
GAS2L2	246176	broad.mit.edu	37	chr17	34073283	34073283	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gtgggaatccttcccctgggGagttcaggggggtatctctc	15	10	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr17:34073283G>A	ENST00000254466.6	-	6	1260	c.1233C>T	c.(1231-1233)ctC>ctT	p.L411L	GAS2L2_ENST00000587565.1_Silent_p.L395L	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	411					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTCCCCTGGGGAGTTCAGGGG	0.597													30	156					0	0	1	0	0	A	34073283	G	A	34073283	2	1	55	1	0	0	0	0	0	0	0	1	6286	1161	41	3		3	GAS2L2	17	34073283	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	28049629	34073283	47121927	52	9412										
ABCA8	10351	broad.mit.edu	37	chr17	66873704	66873704	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cctttcctcagccctttcacGgcggcgtacacctccaggtg	9	17	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr17:66873704G>A	ENST00000269080.2	-	31	4172	c.4035C>T	c.(4033-4035)gcC>gcT	p.A1345A	ABCA8_ENST00000430352.2_Silent_p.A1385A|ABCA8_ENST00000586539.1_Silent_p.A1385A	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1345	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GCCCTTTCACGGCGGCGTACA	0.617													40	226					0	0	1	0	0	A	66873704	G	A	66873704	2	1	55	1	0	0	0	0	0	0	0	1	38	1103	39	1		1	ABCA8	17	66873704	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	32800421	66873704	14321506	53	9413										
PSMG2	56984	broad.mit.edu	37	chr18	12725487	12725487	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gtggaaaataccaagttcttGgagattactctttggcagtg	11	6	2	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr18:12725487G>A	ENST00000317615.6	+	7	1434	c.752G>A	c.(751-753)tGg>tAg	p.W251*	RP11-973H7.2_ENST00000585331.1_RNA	NM_020232.4|NM_147163.1	NP_064617.2|NP_671692.1	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly chaperone 2	251					proteasome assembly	nucleus	protein binding			lung(1)|prostate(2)|skin(1)	4						CCAAGTTCTTGGAGATTACTC	0.373													18	84					0	0	1	0	0	A	12725487	G	A	12725487	4	1	55	1	0	0	0	0	0	1	0	0	12760	1357	47	3	778	3	PSMG2	18	12725487	Nonsense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		12725487	65351761	54	9414										
C19orf57	79173	broad.mit.edu	37	chr19	14000258	14000258	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cggggacacacggaacccctCgaggtctcgttcgaggttct	13	13	2	0			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr19:14000258C>T	ENST00000454313.1	-	6	1469	c.1411G>A	c.(1411-1413)Gag>Aag	p.E471K	C19orf57_ENST00000586783.1_Missense_Mutation_p.E471K|C19orf57_ENST00000346736.2_Missense_Mutation_p.E471K|C19orf57_ENST00000591586.1_Intron			Q0VDD7	CS057_HUMAN	chromosome 19 open reading frame 57	471					multicellular organismal development		protein binding			breast(2)|kidney(1)|lung(3)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CGGAACCCCTCGAGGTCTCGT	0.597													20	123					0	0	1	0	0	T	14000258	C	T	14000258	3	4	55	1	0	0	0	0	1	0	0	0	1951	893	31	1	514	1	C19orf57	19	14000258	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08		14000258	45128725	55	9415										
FUT1	2523	broad.mit.edu	37	chr19	49253880	49253880	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	cctgcagatagtccccacggCgcacgtggacgccgacaaag	12	15	0	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr19:49253880C>T	ENST00000310160.3	-	4	1633	c.659G>A	c.(658-660)cGc>cAc	p.R220H		NM_000148.3	NP_000139.1	P19526	FUT1_HUMAN	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	220					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(3)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		GTCCCCACGGCGCACGTGGAC	0.692													32	171					0	0	1	0	0	T	49253880	C	T	49253880	3	4	55	1	0	0	0	0	1	0	0	0	6135	768	27	1	442	1	FUT1	19	49253880	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	35253622	49253880	9875103	56	9416										
ZNF415	55786	broad.mit.edu	37	chr19	53612426	53612426	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tctctccagtgtgaactctcCgatgtagtgcaaggcatgag	11	10	2	2	rs138480197	byFrequency	TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr19:53612426C>T	ENST00000455735.2	-	7	1336	c.1016G>A	c.(1015-1017)cGg>cAg	p.R339Q	ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000243643.4_Missense_Mutation_p.R291Q|ZNF415_ENST00000440291.1_Missense_Mutation_p.R278Q|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000594011.1_3'UTR|ZNF415_ENST00000421033.1_Missense_Mutation_p.R303Q|ZNF415_ENST00000500065.4_Missense_Mutation_p.R291Q|ZNF415_ENST00000448501.1_Missense_Mutation_p.R339Q|ZNF415_ENST00000601493.1_Missense_Mutation_p.R61Q|ZNF415_ENST00000597748.1_3'UTR			Q09FC8	ZN415_HUMAN	zinc finger protein 415	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding	p.R291L(1)		breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		GTGAACTCTCCGATGTAGTGC	0.418													7	40					0	0	1	0	0	T	53612426	C	T	53612426	3	4	55	1	0	0	0	0	1	0	0	0	17948	652	23	1	799	1	ZNF415	19	53612426	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	4358546	53612426	5516557	57	9417										
POLR3F	10621	broad.mit.edu	37	chr20	18462374	18462374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	gcacagttggcagtgtagatGgacacatgaaactgtacagg	13	7	0	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr20:18462374G>A	ENST00000377603.4	+	8	1173	c.793G>A	c.(793-795)Gga>Aga	p.G265R	POLR3F_ENST00000462997.1_3'UTR	NM_006466.2	NP_006457.2	Q9H1D9	RPC6_HUMAN	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa	265				AKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLC -> C KRRHSWQCRWTHETVQGSQSNHPSHRFGPGHPVDSA (in Ref. 1).	innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|protein binding			breast(2)	2						CAGTGTAGATGGACACATGAA	0.478													6	281					0	0	1	0	0	A	18462374	G	A	18462374	3	1	55	1	0	0	0	0	1	0	0	0	12280	1349	47	3	823	3	POLR3F	20	18462374	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		18462374	44563146	58	9418										
NDRG3	57446	broad.mit.edu	37	chr20	35317150	35317150	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tgggtaagcctcttatagtgAcgtggaccacaccatgagtt	11	9	1	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chr20:35317150A>G	ENST00000373803.2	-	4	187	c.131T>C	c.(130-132)gTc>gCc	p.V44A	NDRG3_ENST00000540765.1_Intron|NDRG3_ENST00000349004.1_Missense_Mutation_p.V44A|NDRG3_ENST00000373773.3_Intron|NDRG3_ENST00000359675.2_Missense_Mutation_p.V32A			Q9UGV2	NDRG3_HUMAN	NDRG family member 3	44					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Myeloproliferative disorder(115;0.00878)				TCTTATAGTGACGTGGACCAC	0.383													10	56					0	0	1	0	0	G	35317150	A	G	35317150	3	3	55	1	0	0	0	0	1	0	0	0	10299	275	10	4	1048	4	NDRG3	20	35317150	Missense_Mutation	SNP	A	TCGA-NG-A4VW-01A-11D-A28R-08	16854776	35317150	27708370	59	9419										
CSF2RA	0	broad.mit.edu	37	chrX	1414328	1414328	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	ttttgtttctagaatacccaGcctggcacggaaaacctact	7	11	1	1			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chrX:1414328G>C	ENST00000381524.3	+	9	975	c.789G>C	c.(787-789)caG>caC	p.Q263H	CSF2RA_ENST00000417535.2_Missense_Mutation_p.Q263H|CSF2RA_ENST00000355805.2_Intron|CSF2RA_ENST00000381509.3_Missense_Mutation_p.Q263H|CSF2RA_ENST00000432318.2_Missense_Mutation_p.Q263H|CSF2RA_ENST00000501036.2_Missense_Mutation_p.Q130H|CSF2RA_ENST00000355432.3_Missense_Mutation_p.Q263H|CSF2RA_ENST00000381500.1_Missense_Mutation_p.Q263H|CSF2RA_ENST00000381529.3_Missense_Mutation_p.Q263H|CSF2RA_ENST00000498153.1_3'UTR|CSF2RA_ENST00000361536.3_Missense_Mutation_p.Q263H			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	263						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGAATACCCAGCCTGGCACGG	0.483													54	225					0	0	1	0	0	C	1414328	G	C	1414328	3	2	55	1	0	0	0	0	1	0	0	0	3959	962	34	5	815	5	CSF2RA	23	1414328	Missense_Mutation	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08		1414328	153856232	60	9420										
FLNA	0	broad.mit.edu	37	chrX	153578523	153578523	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tgggtgccgttgaacttgacGtcaatcaggtaaacgccatt	11	9	2	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chrX:153578523G>A	ENST00000422373.1	-	44	7433	c.7185C>T	c.(7183-7185)gaC>gaT	p.D2395D	FLNA_ENST00000369856.3_Silent_p.D536D|FLNA_ENST00000498491.1_5'UTR|FLNA_ENST00000360319.4_Silent_p.D2395D|FLNA_ENST00000344736.4_Silent_p.D2363D|FLNA_ENST00000369850.3_Silent_p.D2403D	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2403					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGAACTTGACGTCAATCAGGT	0.592											OREG0003592	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	56	224					0	0	1	0	0	A	153578523	G	A	153578523	2	1	55	1	0	0	0	0	0	0	0	1	5965	1136	40	1		1	FLNA	23	153578523	Silent	SNP	G	TCGA-NG-A4VW-01A-11D-A28R-08	152164195	153578523	1692037	61	9421										
FLNA	0	broad.mit.edu	37	chrX	153592412	153592412	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0491803278688525	3	1	0.542043399638336	0	0.569145569620253	0.142857142857143	0.651583710407241	0	tgaaggggctgttggggatgCtgacgcctccccaggacacc	15	12	0	2			TCGA-NG-A4VW-01A-11D-A28R-08	TCGA-NG-A4VW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	036c7c6a-32e0-4837-a8a6-4d230860dc1c	c3915350-561b-448e-af59-7d96f4e95b64	g.chrX:153592412C>G	ENST00000422373.1	-	15	2506	c.2258G>C	c.(2257-2259)aGc>aCc	p.S753T	FLNA_ENST00000360319.4_Missense_Mutation_p.S753T|FLNA_ENST00000344736.4_Missense_Mutation_p.S753T|FLNA_ENST00000369850.3_Missense_Mutation_p.S753T	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	753					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTTGGGGATGCTGACGCCTCC	0.577													40	147					0	0	1	0	0	G	153592412	C	G	153592412	3	3	55	1	0	0	0	0	1	0	0	0	5965	797	28	5	5821	5	FLNA	23	153592412	Missense_Mutation	SNP	C	TCGA-NG-A4VW-01A-11D-A28R-08	13889	153592412	1678148	62	9422										
DHX9	1660	broad.mit.edu	37	chr1	182829308	182829308	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gagcagcagagtgtaacatcGtagtaactcaggtaagtggt	13	6	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr1:182829308G>T	ENST00000367549.3	+	12	1431	c.1321G>T	c.(1321-1323)Gta>Tta	p.V441L		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	441	Helicase ATP-binding.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GTGTAACATCGTAGTAACTCA	0.378													22	45					5.26018e-13	6.11318e-13	1	1	0	T	182829308	G	T	182829308	3	4	56	1	0	0	0	0	1	0	0	0	4544	1145	40	5	1363	5	DHX9	1	182829308	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		182829308	66421313	1	9423										
PLEKHA6	22874	broad.mit.edu	37	chr1	204237436	204237436	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cggctttgcgggctgtgcgaGttgcctgggggcagagagag	20	8	0	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr1:204237436G>C	ENST00000272203.3	-	4	423	c.107C>G	c.(106-108)aCt>aGt	p.T36S	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.T36S	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	36										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGCTGTGCGAGTTGCCTGGGG	0.597													33	29					0	0	1	0	0	C	204237436	G	C	204237436	3	2	56	1	0	0	0	0	1	0	0	0	12107	1029	36	5	3115	5	PLEKHA6	1	204237436	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	21408128	204237436	45013185	2	9424										
CNTN2	6900	broad.mit.edu	37	chr1	205031674	205031674	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	taagcacggtaccatctacgCcagcgccgagctagccgtgc	11	15	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr1:205031674C>T	ENST00000331830.4	+	10	1501	c.1217C>T	c.(1216-1218)gCc>gTc	p.A406V		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	406	Ig-like C2-type 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACCATCTACGCCAGCGCCGAG	0.582													42	39					0	0	1	0	0	T	205031674	C	T	205031674	3	4	56	1	0	0	0	0	1	0	0	0	3664	739	26	3	1251	3	CNTN2	1	205031674	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	794238	205031674	44218947	3	9425										
MAP2	4133	broad.mit.edu	37	chr2	210559085	210559085	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tttctcctctggcttccgatAttctaaccaacactagtgga	6	12	3	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr2:210559085A>G	ENST00000360351.4	+	7	2697	c.2191A>G	c.(2191-2193)Att>Gtt	p.I731V	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.I727V|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	731					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GGCTTCCGATATTCTAACCAA	0.468													36	143					0	0	1	0	0	G	210559085	A	G	210559085	3	3	56	1	0	0	0	0	1	0	0	0	9284	449	16	4	2205	4	MAP2	2	210559085	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08		210559085	32640288	4	9426										
IL5RA	0	broad.mit.edu	37	chr3	3143448	3143448	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gtcgttctgcaggatggtccGcacacttgctgaaaagcctt	11	11	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr3:3143448G>A	ENST00000446632.2	-	5	869	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W	IL5RA_ENST00000430514.2_Missense_Mutation_p.R99W|IL5RA_ENST00000256452.3_Missense_Mutation_p.R99W|IL5RA_ENST00000445864.2_Missense_Mutation_p.R99W|IL5RA_ENST00000418488.2_Missense_Mutation_p.R99W|IL5RA_ENST00000456302.1_Missense_Mutation_p.R99W|IL5RA_ENST00000438560.1_Missense_Mutation_p.R99W|IL5RA_ENST00000311981.8_Missense_Mutation_p.R99W|IL5RA_ENST00000383846.1_Missense_Mutation_p.R99W	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	99					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AGGATGGTCCGCACACTTGCT	0.463													17	21					0	0	1	0	0	A	3143448	G	A	3143448	3	1	56	1	0	0	0	0	1	0	0	0	7743	1086	38	1	1025	1	IL5RA	3	3143448	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		3143448	194878982	5	9427										
CORIN	10699	broad.mit.edu	37	chr4	47682239	47682239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ggcgatgcagcgcccgtcccCgcagcgatgctctgttgtgg	15	14	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr4:47682239C>T	ENST00000273857.4	-	8	1050	c.1051G>A	c.(1051-1053)Ggg>Agg	p.G351R	CORIN_ENST00000504584.1_Intron|CORIN_ENST00000502252.1_Missense_Mutation_p.G284R|CORIN_ENST00000505909.1_Intron|CORIN_ENST00000508498.1_Missense_Mutation_p.G212R	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	351	LDL-receptor class A 3.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CGCCCGTCCCCGCAGCGATGC	0.547													35	17					0	0	1	0	0	T	47682239	C	T	47682239	3	4	56	1	0	0	0	0	1	0	0	0	3775	652	23	1	2137	1	CORIN	4	47682239	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		47682239	143472037	6	9428										
MAB21L2	10586	broad.mit.edu	37	chr4	151504556	151504556	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gcgtcgggctatctctcagcGcgtaagatccgctcgcgttt	12	13	2	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr4:151504556G>A	ENST00000317605.4	+	1	1480	c.375G>A	c.(373-375)gcG>gcA	p.A125A	LRBA_ENST00000510413.1_Intron|LRBA_ENST00000535741.1_Intron|LRBA_ENST00000357115.3_Intron|LRBA_ENST00000507224.1_Intron	NM_006439.4	NP_006430.1	Q9Y586	MB212_HUMAN	mab-21-like 2 (C. elegans)	125					nervous system development	nucleus				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	21	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		ATCTCTCAGCGCGTAAGATCC	0.627													41	105					0	0	1	0	0	A	151504556	G	A	151504556	2	1	56	1	0	0	0	0	0	0	0	1	9187	1074	38	1		1	MAB21L2	4	151504556	Silent	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	103822317	151504556	39649720	7	9429										
CEP72	55722	broad.mit.edu	37	chr5	639302	639302	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ctggtggacaggagctggggCggctgcaggtccctgcacag	18	11	0	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr5:639302C>T	ENST00000264935.5	+	8	1395	c.1305C>T	c.(1303-1305)ggC>ggT	p.G435G	CEP72_ENST00000444221.1_3'UTR	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	435					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			GGAGCTGGGGCGGCTGCAGGT	0.672													13	106					0	0	1	0	0	T	639302	C	T	639302	2	4	56	1	0	0	0	0	0	0	0	1	3282	755	27	1		1	CEP72	5	639302	Silent	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		639302	180275958	8	9430										
SNCAIP	9627	broad.mit.edu	37	chr5	121759376	121759376	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cccagaagaaaggagtgagtAtctgaaaaaagtgaaaagca	11	5	1	5			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr5:121759376A>C	ENST00000261367.7	+	6	2513	c.1085A>C	c.(1084-1086)tAt>tCt	p.Y362S	SNCAIP_ENST00000503116.2_Missense_Mutation_p.Y362S|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.Y315S|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000261368.8_Missense_Mutation_p.Y315S|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.Y362S			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	315					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AGGAGTGAGTATCTGAAAAAA	0.448													19	103					0	0	1	0	0	C	121759376	A	C	121759376	3	2	56	1	0	0	0	0	1	0	0	0	14894	449	16	4	954	4	SNCAIP	5	121759376	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08	121120074	121759376	59155884	9	9431										
FAT2	2196	broad.mit.edu	37	chr5	150923476	150923476	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gtgtctctgctgtcagggtcAatagcctggactttaagaac	11	9	3	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr5:150923476A>C	ENST00000261800.5	-	9	7224	c.7212T>G	c.(7210-7212)atT>atG	p.I2404M		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2404	Cadherin 21.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTCAGGGTCAATAGCCTGGA	0.473													8	42					0	0	1	0	0	C	150923476	A	C	150923476	3	2	56	1	0	0	0	0	1	0	0	0	5722	126	5	4	5897	4	FAT2	5	150923476	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08	29164100	150923476	29991784	10	9432										
GABRA1	2554	broad.mit.edu	37	chr5	161277800	161277800	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ctctacttattctacttttcAgctgctccagcccgcgatga	6	14	3	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr5:161277800A>T	ENST00000428797.2	+	3	340		c.e3-1		GABRA1_ENST00000420560.1_Splice_Site|GABRA1_ENST00000393943.4_Splice_Site|GABRA1_ENST00000444819.1_Splice_Site|GABRA1_ENST00000437025.2_Splice_Site|GABRA1_ENST00000023897.6_Splice_Site	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TCTACTTTTCAGCTGCTCCAG	0.488													11	46					0	0	1	0	0	T	161277800	A	T	161277800	5	4	56	1	0	0	0	0	0	0	1	0	6194	202	7	4		4	GABRA1	5	161277800	Splice_Site	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08	10354324	161277800	19637460	11	9433										
DOCK2	1794	broad.mit.edu	37	chr5	169267840	169267840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gacagtcatcaccatgggccGggatcacattctgattgtga	11	10	4	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr5:169267840G>A	ENST00000256935.8	+	27	2863	c.2783G>A	c.(2782-2784)cGg>cAg	p.R928Q	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.R420Q	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	928					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCATGGGCCGGGATCACATT	0.453													6	22					0	0	1	0	0	A	169267840	G	A	169267840	3	1	56	1	0	0	0	0	1	0	0	0	4714	1116	39	1	2889	1	DOCK2	5	169267840	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	7990040	169267840	11647420	12	9434										
FAM26E	254228	broad.mit.edu	37	chr6	116833169	116833169	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tctacgtcctcggccagatcActctgagctcattggtggct	10	13	4	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr6:116833169A>T	ENST00000368599.3	+	1	361	c.310A>T	c.(310-312)Act>Tct	p.T104S	TRAPPC3L_ENST00000368602.3_Intron|TRAPPC3L_ENST00000356128.4_Intron	NM_153711.2	NP_714922.1	Q8N5C1	FA26E_HUMAN	family with sequence similarity 26, member E	104						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(87;0.0608)|all_epithelial(87;0.05)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0242)|all cancers(137;0.0419)|OV - Ovarian serous cystadenocarcinoma(136;0.0671)|Epithelial(106;0.212)		CGGCCAGATCACTCTGAGCTC	0.522													17	47					0	0	1	0	0	T	116833169	A	T	116833169	3	4	56	1	0	0	0	0	1	0	0	0	5585	159	6	4	312	4	FAM26E	6	116833169	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08		116833169	54281898	13	9435										
KIAA1244	57221	broad.mit.edu	37	chr6	138483289	138483289	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	aagtacaaagccatcaaggaGagctgcacctgggccctggg	13	11	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr6:138483289G>T	ENST00000251691.4	+	1	232	c.66G>T	c.(64-66)gaG>gaT	p.E22D		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	22					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCATCAAGGAGAGCTGCACCT	0.701													23	14					2.44723e-14	2.88304e-14	1	1	0	T	138483289	G	T	138483289	3	4	56	1	0	0	0	0	1	0	0	0	8258	933	33	2	68	2	KIAA1244	6	138483289	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	21650120	138483289	32631778	14	9436										
MEOX2	4223	broad.mit.edu	37	chr7	15725735	15725735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gagccgcactcggtggggaaGacatctgcgggaggtgccag	18	10	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr7:15725735G>C	ENST00000262041.5	-	1	702	c.293C>G	c.(292-294)tCt>tGt	p.S98C		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	98					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CGGTGGGGAAGACATCTGCGG	0.667													7	12					0	0	1	0	0	C	15725735	G	C	15725735	3	2	56	1	0	0	0	0	1	0	0	0	9523	942	33	2	633	2	MEOX2	7	15725735	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		15725735	143412928	15	9437										
HIP1	3092	broad.mit.edu	37	chr7	75184771	75184771	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ttcttcaagctggttcagggCgtcttgtatcacctgctccg	10	12	5	0	rs138838220		TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr7:75184771C>T	ENST00000336926.6	-	19	1938	c.1912G>A	c.(1912-1914)Gcc>Acc	p.A638T	HIP1_ENST00000434438.2_Missense_Mutation_p.A638T	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	638					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TGGTTCAGGGCGTCTTGTATC	0.552			T	PDGFRB	CMML								55	34					0	0	1	0	0	T	75184771	C	T	75184771	3	4	56	1	0	0	0	0	1	0	0	0	7154	768	27	1	1253	1	HIP1	7	75184771	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	59459036	75184771	83953892	16	9438										
CHRM2	1129	broad.mit.edu	37	chr7	136699812	136699812	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ctttttattcagcttggcctGtgctgaccttatcataggtg	9	9	2	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr7:136699812G>C	ENST00000445907.2	+	3	728	c.200G>C	c.(199-201)tGt>tCt	p.C67S	AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.C67S|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000439694.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.C67S|CHRM2_ENST00000397608.3_Missense_Mutation_p.C67S|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.C67S|AC009264.1_ENST00000597642.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.C67S|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000592183.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	67					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	AGCTTGGCCTGTGCTGACCTT	0.458													15	184					0	0	1	0	0	C	136699812	G	C	136699812	3	2	56	1	0	0	0	0	1	0	0	0	3399	1377	48	5	202	5	CHRM2	7	136699812	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	61515041	136699812	22438851	17	9439										
MGAM	8972	broad.mit.edu	37	chr7	141765178	141765178	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	agcgaggggtcgtcatcaccCgctccacatttccctcttct	8	16	4	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr7:141765178C>T	ENST00000475668.2	+	38	4582	c.4528C>T	c.(4528-4530)Cgc>Tgc	p.R1510C	MGAM_ENST00000549489.2_Missense_Mutation_p.R1510C			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1510	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGTCATCACCCGCTCCACATT	0.592													3	33					0	0	1	0	0	T	141765178	C	T	141765178	3	4	56	1	0	0	0	0	1	0	0	0	9590	652	23	1	4674	1	MGAM	7	141765178	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	5065366	141765178	17373485	18	9440										
KRBA1	84626	broad.mit.edu	37	chr7	149418077	149418077	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gatggagagagagcgagcccCgagggtaagtcagacagtgg	18	7	1	3			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr7:149418077C>T	ENST00000255992.10	+	4	705	c.306C>T	c.(304-306)ccC>ccT	p.P102P	KRBA1_ENST00000319551.8_Silent_p.P102P|KRBA1_ENST00000485033.2_Silent_p.P102P|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	102										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGCGAGCCCCGAGGGTAAGT	0.617													23	40					0	0	1	0	0	T	149418077	C	T	149418077	2	4	56	1	0	0	0	0	0	0	0	1	8481	639	23	1		1	KRBA1	7	149418077	Silent	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	7652899	149418077	9720586	19	9441										
REPIN1	29803	broad.mit.edu	37	chr7	150069555	150069555	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ccttcacctgcgccgagtgcGggaagaacttcggcaagaag	13	12	1	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr7:150069555G>A	ENST00000397281.2	+	4	1714	c.1225G>A	c.(1225-1227)Ggg>Agg	p.G409R	REPIN1_ENST00000489432.2_Missense_Mutation_p.G466R|REPIN1_ENST00000425389.2_Missense_Mutation_p.G409R|REPIN1_ENST00000540729.1_Missense_Mutation_p.G409R|REPIN1_ENST00000444957.1_Missense_Mutation_p.G409R|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000479668.1_3'UTR	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	409					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CGCCGAGTGCGGGAAGAACTT	0.721													3	11					0	0	1	0	0	A	150069555	G	A	150069555	3	1	56	1	0	0	0	0	1	0	0	0	13278	1116	39	1	1402	1	REPIN1	7	150069555	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	651478	150069555	9069108	20	9442										
INTS10	55174	broad.mit.edu	37	chr8	19682374	19682374	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	agatacatgaacaactttgaTagtgaagcacatgcaaaata	7	6	0	4			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr8:19682374T>C	ENST00000397977.3	+	8	1295	c.897T>C	c.(895-897)gaT>gaC	p.D299D		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	299					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		ACAACTTTGATAGTGAAGCAC	0.363													41	20					0	0	1	0	0	C	19682374	T	C	19682374	2	2	56	1	0	0	0	0	0	0	0	1	7819	1403	49	4		4	INTS10	8	19682374	Silent	SNP	T	TCGA-QM-A5NM-01A-11D-A28R-08		19682374	126681648	21	9443										
EBF2	64641	broad.mit.edu	37	chr8	25720242	25720242	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	taccttagctaatctctcagGatctccaggatgcctaggga	9	11	3	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr8:25720242G>T	ENST00000520164.1	-	11	1618	c.1081C>A	c.(1081-1083)Cct>Act	p.P361T	EBF2_ENST00000535548.1_Missense_Mutation_p.P92T|EBF2_ENST00000408929.3_Missense_Mutation_p.P213T	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	361					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AATCTCTCAGGATCTCCAGGA	0.418													10	67					0.000442599	0.000458597	1	1	0	T	25720242	G	T	25720242	3	4	56	1	0	0	0	0	1	0	0	0	4907	1174	41	2	670	2	EBF2	8	25720242	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	6037868	25720242	120643780	22	9444										
GOLGA7	51125	broad.mit.edu	37	chr8	41363429	41363429	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tgtggtgtttctttctgtcaGgttctgaagaaagtctccaa	10	7	5	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr8:41363429G>A	ENST00000357743.4	+	3	465		c.e3-1		GOLGA7_ENST00000518270.1_Splice_Site|GOLGA7_ENST00000405786.2_Splice_Site|GOLGA7_ENST00000520817.1_Splice_Site|GOLGA7_ENST00000521417.1_Splice_Site	NM_001002296.1	NP_001002296.1	Q7Z5G4	GOGA7_HUMAN	golgin A7							Golgi membrane				breast(1)|large_intestine(1)	2	Ovarian(28;0.014)|Colorectal(14;0.0234)|Lung SC(25;0.211)	all_lung(54;0.000771)|Lung NSC(58;0.0031)|Hepatocellular(245;0.014)|Esophageal squamous(32;0.0559)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00596)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			CTTTCTGTCAGGTTCTGAAGA	0.438													5	38					0	0	1	0	0	A	41363429	G	A	41363429	5	1	56	1	0	0	0	0	0	0	1	0	6600	1014	35	3	274	3	GOLGA7	8	41363429	Splice_Site	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	15643187	41363429	105000593	23	9445										
PTEN	5728	broad.mit.edu	37	chr10	89624275	89624275	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gcagaaacaaaaggagatatCaagaggatggattcgactta	11	5	1	3			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr10:89624275C>T	ENST00000371953.3	+	1	1406	c.49C>T	c.(49-51)Caa>Taa	p.Q17*		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	17	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(13)|p.Q17*(5)|p.Q17del(2)|p.R15fs*23(1)|p.R14fs*26(1)|p.Y16fs*21(1)|p.N12fs*6(1)|p.R14_D22del(1)|p.Y16fs*1(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAGGAGATATCAAGAGGATGG	0.478		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			50	60					0	0	1	0	0	T	89624275	C	T	89624275	4	4	56	1	0	0	0	0	0	1	0	0	12786	827	29	3	51	3	PTEN	10	89624275	Nonsense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		89624275	45910472	24	9446										
PTEN	5728	broad.mit.edu	37	chr10	89720780	89720780	+	Frame_Shift_Del	DEL	A	A	-													0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gcagtatagagcgtgcagatAatgacaaggaatatctagta							TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr10:89720780delA	ENST00000371953.3	+	8	2288	c.931delA	c.(931-933)atfs	p.N311fs	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	311	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.W274_F341del(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GCGTGCAGATAATGACAAGGA	0.348		31	"D, Mis, N, F, S"		"glioma,  prostate, endometrial"	"harmartoma, glioma,  prostate, endometrial"			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			33	46	---	---	---	---						-	89720780	A	-	89720780	7	5	56	1	0	1	0	1	0	0	0	0	12786	362	13	0	961	0	PTEN	10	89720780	Frame_Shift_Del	DEL	A	TCGA-QM-A5NM-01A-11D-A28R-08	96505	89720780	45813967	25	9447										
MUC2	4583	broad.mit.edu	37	chr11	1092954	1092954	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cccatcaccaccaccactacGgtgaccccaaccccaacacc	3	23	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr11:1092954G>A	ENST00000359061.5	+	30	4776	c.4776_splice	c.e30+1	p.T1592_splice	MUC2_ENST00000441003.2_Silent_p.T1591T|MUC2_ENST00000361558.6_Intron			Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1594	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ccaccactacggtgaccccaa	0.627													3	6					0	0	1	0	0	A	1092954	G	A	1092954	5	1	56	1	0	0	0	0	0	0	1	0	10022	1103	39	1	4891	1	MUC2	11	1092954	Splice_Site	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		1092954	133913562	26	9448										
PSMA1	5682	broad.mit.edu	37	chr11	14535162	14535162	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tccaagtaagtacgagctgaTtgggaacgggctccaatgga	13	8	0	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr11:14535162T>C	ENST00000555531.1	-	6	484	c.440A>G	c.(439-441)aAt>aGt	p.N147S	PSMA1_ENST00000396394.2_Silent_p.Q166Q|PSMA1_ENST00000418988.2_Silent_p.Q172Q|PSMA1_ENST00000530457.1_Silent_p.Q141Q|PSMA1_ENST00000396393.1_Silent_p.Q166Q|PSMA1_ENST00000419365.2_Missense_Mutation_p.N147S			P25786	PSA1_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 1	0					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3						TACGAGCTGATTGGGAACGGG	0.388													32	31					0	0	1	0	0	C	14535162	T	C	14535162	3	2	56	1	0	0	0	0	1	0	0	0	12714	1490	52	4	309	4	PSMA1	11	14535162	Missense_Mutation	SNP	T	TCGA-QM-A5NM-01A-11D-A28R-08	13442208	14535162	120471354	27	9449										
OR5D18	219438	broad.mit.edu	37	chr11	55587891	55587891	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	atcctcttcctttactgtgtGcccaactccaaaaactccag	4	15	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr11:55587891G>T	ENST00000333976.4	+	1	806	c.786G>T	c.(784-786)gtG>gtT	p.V262V		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V262V(1)		NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TTTACTGTGTGCCCAACTCCA	0.527													32	26					1.13719e-10	1.30398e-10	1	1	0	T	55587891	G	T	55587891	2	4	56	1	0	0	0	0	0	0	0	1	11203	1306	46	5		5	OR5D18	11	55587891	Silent	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	41052729	55587891	79418625	28	9450										
GALNT8	26290	broad.mit.edu	37	chr12	4855406	4855406	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ctcatctatggaggagagaaCgtggagcttagcctgagggt	15	7	2	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr12:4855406C>T	ENST00000252318.2	+	6	1492	c.1155C>T	c.(1153-1155)aaC>aaT	p.N385N		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	385	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						GAGGAGAGAACGTGGAGCTTA	0.498													37	56					0	0	1	0	0	T	4855406	C	T	4855406	2	4	56	1	0	0	0	0	0	0	0	1	6258	535	19	1		1	GALNT8	12	4855406	Silent	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		4855406	128996489	29	9451										
FGD6	55785	broad.mit.edu	37	chr12	95602757	95602757	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	actcttgagttttccgtataGccataataaatggcaagttc	7	8	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr12:95602757G>A	ENST00000343958.4	-	2	2526	c.2303C>T	c.(2302-2304)gCt>gTt	p.A768V	FGD6_ENST00000549499.1_Missense_Mutation_p.A768V|FGD6_ENST00000546711.1_Missense_Mutation_p.A768V	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	768					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TTTCCGTATAGCCATAATAAA	0.443													15	64					0	0	1	0	0	A	95602757	G	A	95602757	3	1	56	1	0	0	0	0	1	0	0	0	5869	971	34	3	2069	3	FGD6	12	95602757	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	90747351	95602757	38249138	30	9452										
ANKRD13A	88455	broad.mit.edu	37	chr12	110454197	110454197	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tttgtctgcccttcaggctcCggatttctatgtgcagatga	10	10	3	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr12:110454197C>T	ENST00000261739.4	+	4	525	c.359C>T	c.(358-360)cCg>cTg	p.P120L	ANKRD13A_ENST00000550404.1_3'UTR	NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	120										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						CTTCAGGCTCCGGATTTCTAT	0.433													38	18					0	0	1	0	0	T	110454197	C	T	110454197	3	4	56	1	0	0	0	0	1	0	0	0	637	652	23	1	373	1	ANKRD13A	12	110454197	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	14851440	110454197	23397698	31	9453										
FKBP3	2287	broad.mit.edu	37	chr14	45590702	45590702	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	acttacttgtttgaatattaGtatcaaaaacagtcccatct	4	8	2	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr14:45590702G>A	ENST00000216330.3	-	5	850	c.440C>T	c.(439-441)aCt>aTt	p.T147I	FKBP3_ENST00000396062.3_Missense_Mutation_p.T147I			Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	147	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity			NS(1)|biliary_tract(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	12						TTGAATATTAGTATCAAAAAC	0.363													5	35					0	0	1	0	0	A	45590702	G	A	45590702	3	1	56	1	0	0	0	0	1	0	0	0	5941	1029	36	3	250	3	FKBP3	14	45590702	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		45590702	61758838	32	9454										
NID2	22795	broad.mit.edu	37	chr14	52520497	52520497	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tttcggggtacggtggtgggGtttcccaggaaggagccagt	18	7	0	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr14:52520497G>A	ENST00000216286.5	-	5	1228	c.1229C>T	c.(1228-1230)aCc>aTc	p.T410I	NID2_ENST00000541773.1_Missense_Mutation_p.T357I	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	410						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CGGTGGTGGGGTTTCCCAGGA	0.557													39	53					0	0	1	0	0	A	52520497	G	A	52520497	3	1	56	1	0	0	0	0	1	0	0	0	10461	1261	44	3	2970	3	NID2	14	52520497	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	6929795	52520497	54829043	33	9455										
SIX4	51804	broad.mit.edu	37	chr14	61180412	61180412	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ttcagctgtaggaactatttCcccaagggcagcctgagtca	10	11	2	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr14:61180412C>T	ENST00000216513.4	-	3	2118	c.2059G>A	c.(2059-2061)Gaa>Aaa	p.E687K		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	687						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GGAACTATTTCCCCAAGGGCA	0.473													22	13					0	0	1	0	0	T	61180412	C	T	61180412	3	4	56	1	0	0	0	0	1	0	0	0	14403	864	30	3	290	3	SIX4	14	61180412	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	8659915	61180412	46169128	34	9456										
FSD2	123722	broad.mit.edu	37	chr15	83455920	83455920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ttcaagtccatataagtggaCaagttcatccacttcctctt	5	11	3	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr15:83455920C>T	ENST00000334574.8	-	2	404	c.223G>A	c.(223-225)Gtc>Atc	p.V75I	FSD2_ENST00000541889.1_Missense_Mutation_p.V75I			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	75										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						TATAAGTGGACAAGTTCATCC	0.423													14	75					0	0	1	0	0	T	83455920	C	T	83455920	3	4	56	1	0	0	0	0	1	0	0	0	6105	478	17	3	2074	3	FSD2	15	83455920	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		83455920	19075472	35	9457										
PLK1	5347	broad.mit.edu	37	chr16	23700935	23700935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cctacctacggacctggttcCgcacccgcagcgccatcatc	8	19	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr16:23700935C>T	ENST00000300093.4	+	9	1657	c.1546C>T	c.(1546-1548)Cgc>Tgc	p.R516C		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	516	POLO box 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		GACCTGGTTCCGCACCCGCAG	0.632													21	29					0	0	1	0	0	T	23700935	C	T	23700935	3	4	56	1	0	0	0	0	1	0	0	0	12141	652	23	1	1580	1	PLK1	16	23700935	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		23700935	66653818	36	9458										
XPO6	23214	broad.mit.edu	37	chr16	28118920	28118920	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gcgactggtagcaaatctgtCgagacttggtggactccccc	12	12	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr16:28118920C>G	ENST00000304658.5	-	18	2920	c.2420G>C	c.(2419-2421)cGa>cCa	p.R807P	XPO6_ENST00000565698.1_Missense_Mutation_p.R793P	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	807					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						GCAAATCTGTCGAGACTTGGT	0.512													17	86					0	0	1	0	0	G	28118920	C	G	28118920	3	3	56	1	0	0	0	0	1	0	0	0	17507	884	31	2	985	2	XPO6	16	28118920	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	4417985	28118920	62235833	37	9459										
PRPF8	10594	broad.mit.edu	37	chr17	1563731	1563731	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tcgattccagcccacctgacAtaagtccataacaatgctct	5	14	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr17:1563731A>G	ENST00000572621.1	-	29	5045	c.4780T>C	c.(4780-4782)Tgt>Cgt	p.C1594R	PRPF8_ENST00000304992.6_Missense_Mutation_p.C1594R			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1594						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CCCACCTGACATAAGTCCATA	0.522													380	26					0	0	1	0	0	G	1563731	A	G	1563731	3	3	56	1	0	0	0	0	1	0	0	0	12626	217	8	4	2283	4	PRPF8	17	1563731	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08		1563731	79631479	38	9460										
PHF23	79142	broad.mit.edu	37	chr17	7142121	7142121	+	Frame_Shift_Del	DEL	G	G	-													0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ccacctctccgacaatcaccGggcattctccggcggcaact							TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr17:7142121delG	ENST00000454255.2	-	1	128	c.6delC	c.(4-6)ccfs	p.P2fs	PHF23_ENST00000576955.1_Intron|PHF23_ENST00000320316.3_Intron|PHF23_ENST00000571362.1_Intron			Q9BUL5	PHF23_HUMAN	PHD finger protein 23	0							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						GACAATCACCGGGCATTCTCC	0.622													2	4	---	---	---	---						-	7142121	G	-	7142121	7	5	56	1	0	1	0	1	0	0	0	0	11882	1131	39	0		0	PHF23	17	7142121	Frame_Shift_Del	DEL	G	TCGA-QM-A5NM-01A-11D-A28R-08	5578390	7142121	74053089	39	9461										
TP53	7157	broad.mit.edu	37	chr17	7577557	7577557	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ccggttcatgccgcccatgcAggaactgttacacatgtagt	10	12	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr17:7577557A>T	ENST00000420246.2	-	7	856	c.724T>A	c.(724-726)Tgc>Agc	p.C242S	TP53_ENST00000455263.2_Missense_Mutation_p.C242S|TP53_ENST00000413465.2_Missense_Mutation_p.C242S|TP53_ENST00000269305.4_Missense_Mutation_p.C242S|TP53_ENST00000359597.4_Missense_Mutation_p.C242S|TP53_ENST00000445888.2_Missense_Mutation_p.C242S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	242	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242R(12)|p.C242S(10)|p.0?(8)|p.?(5)|p.N239_C242delNSSC(3)|p.C242G(2)|p.S241del(2)|p.N239_C242>S(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*20(1)|p.C242fs*23(1)|p.C242fs*5(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGCCCATGCAGGAACTGTTA	0.577		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	2					0	0	1	0	0	T	7577557	A	T	7577557	3	4	56	1	0	0	0	0	1	0	0	0	16441	188	7	4	566	4	TP53	17	7577557	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08	435436	7577557	73617653	40	9462										
JUP	3728	broad.mit.edu	37	chr17	39914009	39914009	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	caccccggcagccacgcgctGgatgttctccaccgacgagt	11	17	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr17:39914009G>C	ENST00000393931.3	-	11	1919	c.1801C>G	c.(1801-1803)Cag>Gag	p.Q601E	JUP_ENST00000310706.5_Missense_Mutation_p.Q601E|JUP_ENST00000540235.1_Intron|JUP_ENST00000393930.1_Missense_Mutation_p.Q601E	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	601					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCCACGCGCTGGATGTTCTCC	0.667													38	0					0	0	1	0	0	C	39914009	G	C	39914009	3	2	56	1	0	0	0	0	1	0	0	0	8015	1357	47	5	452	5	JUP	17	39914009	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	32336452	39914009	41281201	41	9463										
SERPINB7	8710	broad.mit.edu	37	chr18	61449729	61449729	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ctcttcgctgccctggccctGgtccgcttgggcgctcaaga	12	16	2	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr18:61449729G>T	ENST00000398019.2	+	2	448	c.123G>T	c.(121-123)ctG>ctT	p.L41L	SERPINB7_ENST00000336429.2_Silent_p.L41L|SERPINB7_ENST00000546027.1_Silent_p.L41L|SERPINB7_ENST00000540675.1_Silent_p.L41L	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	41					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				CCCTGGCCCTGGTCCGCTTGG	0.473													19	68					1.67942e-08	1.87571e-08	1	1	0	T	61449729	G	T	61449729	2	4	56	1	0	0	0	0	0	0	0	1	14159	1335	47	5		5	SERPINB7	18	61449729	Silent	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		61449729	16627519	42	9464										
FBN3	84467	broad.mit.edu	37	chr19	8196507	8196507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cggattggcacagcagcactCggacttggtgacagtgccag	14	11	0	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr19:8196507C>T	ENST00000600128.1	-	15	2335	c.1921G>A	c.(1921-1923)Gag>Aag	p.E641K	FBN3_ENST00000601739.1_Missense_Mutation_p.E641K|FBN3_ENST00000270509.2_Missense_Mutation_p.E641K			Q75N90	FBN3_HUMAN	fibrillin 3	641	TB 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CAGCAGCACTCGGACTTGGTG	0.667													40	45					0	0	1	0	0	T	8196507	C	T	8196507	3	4	56	1	0	0	0	0	1	0	0	0	5736	893	31	1	6708	1	FBN3	19	8196507	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		8196507	50932476	43	9465										
MARCH2	51257	broad.mit.edu	37	chr19	8486873	8486873	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ggatggccggctcctctccaCcgtcatccgtgccttggaca	11	16	2	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr19:8486873C>T	ENST00000602117.1	+	2	604	c.149C>T	c.(148-150)aCc>aTc	p.T50I	MARCH2_ENST00000393944.1_Missense_Mutation_p.T50I|MARCH2_ENST00000381035.4_Missense_Mutation_p.T50I|MARCH2_ENST00000601283.1_Intron|MARCH2_ENST00000215555.2_Missense_Mutation_p.T50I			Q9P0N8	MARH2_HUMAN	membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase	50					endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|skin(1)|urinary_tract(1)	10						CTCCTCTCCACCGTCATCCGT	0.627													19	54					0	0	1	0	0	T	8486873	C	T	8486873	3	4	56	1	0	0	0	0	1	0	0	0	9350	507	18	3	151	3	MARCH2	19	8486873	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	290366	8486873	50642110	44	9466										
CACNA1A	773	broad.mit.edu	37	chr19	13409679	13409679	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ggtgggggtccccggccttgCctcgctcggcctcgccctcc	14	19	0	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr19:13409679C>T	ENST00000360228.5	-	19	2767	c.2768G>A	c.(2767-2769)gGc>gAc	p.G923D	CACNA1A_ENST00000573710.2_Missense_Mutation_p.G924D	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	924					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCCGGCCTTGCCTCGCTCGGC	0.771													10	5					0	0	1	0	0	T	13409679	C	T	13409679	3	4	56	1	0	0	0	0	1	0	0	0	2556	739	26	3	4970	3	CACNA1A	19	13409679	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	4922806	13409679	45719304	45	9467										
SLC25A42	284439	broad.mit.edu	37	chr19	19216533	19216533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cagctactatggcttccgtgGagagtgaggccccgccccgc	13	15	0	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr19:19216533G>A	ENST00000318596.7	+	5	528	c.377G>A	c.(376-378)gGa>gAa	p.G126E	SLC25A42_ENST00000600275.1_Intron	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	126					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			GGCTTCCGTGGAGAGTGAGgc	0.672													4	5					0	0	1	0	0	A	19216533	G	A	19216533	3	1	56	1	0	0	0	0	1	0	0	0	14561	1174	41	3	391	3	SLC25A42	19	19216533	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	5806854	19216533	39912450	46	9468										
CHST8	64377	broad.mit.edu	37	chr19	34263305	34263305	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cccaaggccggctgctccaaTtggaagcgggtgctcatggt	14	12	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr19:34263305T>C	ENST00000262622.3	+	4	1370	c.612T>C	c.(610-612)aaT>aaC	p.N204N	CHST8_ENST00000434302.1_Silent_p.N204N|CHST8_ENST00000438847.2_Silent_p.N204N	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	204					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					GCTGCTCCAATTGGAAGCGGG	0.682													54	65					0	0	1	0	0	C	34263305	T	C	34263305	2	2	56	1	0	0	0	0	0	0	0	1	3432	1490	52	4		4	CHST8	19	34263305	Silent	SNP	T	TCGA-QM-A5NM-01A-11D-A28R-08	15046772	34263305	24865678	47	9469										
PPP2R1A	5518	broad.mit.edu	37	chr19	52716084	52716084	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	ccaacctggcctctgacgagCaggtgagttttgcttcctgg	12	12	1	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr19:52716084C>A	ENST00000322088.6	+	5	707	c.649C>A	c.(649-651)Cag>Aag	p.Q217K	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.Q162K|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.Q38K	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	217	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CTCTGACGAGCAGGTGAGTTT	0.597			Mis		clear cell ovarian carcinoma								81	91					5.41189e-41	6.46421e-41	1	1	0	A	52716084	C	A	52716084	3	1	56	1	0	0	0	0	1	0	0	0	12430	711	25	5	667	5	PPP2R1A	19	52716084	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	18452779	52716084	6412899	48	9470										
TGM6	343641	broad.mit.edu	37	chr20	2377168	2377168	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tcagaggacgatgtgtttctGgcctcagaggaggagagaca	15	7	3	3			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr20:2377168G>T	ENST00000202625.2	+	4	502	c.441G>T	c.(439-441)ctG>ctT	p.L147L	TGM6_ENST00000477505.1_Intron|TGM6_ENST00000381423.1_Silent_p.L147L	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	147					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	ATGTGTTTCTGGCCTCAGAGG	0.617													12	89					9.31168e-06	1.02667e-05	1	1	0	T	2377168	G	T	2377168	2	4	56	1	0	0	0	0	0	0	0	1	15893	1335	47	5		5	TGM6	20	2377168	Silent	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08		2377168	60648352	49	9471										
RBBP9	10741	broad.mit.edu	37	chr20	18477788	18477788	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cctccgttcccgggaacaatCactgccttgctaggagaagc	10	14	1	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr20:18477788C>T	ENST00000337227.4	-	1	99	c.24G>A	c.(22-24)gtG>gtA	p.V8V	RBBP9_ENST00000493184.1_5'UTR	NM_006606.2	NP_006597.2	O75884	RBBP9_HUMAN	retinoblastoma binding protein 9	8						cytoplasm|nucleus	hydrolase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|prostate(1)	9						CGGGAACAATCACTGCCTTGC	0.662													4	46					0	0	1	0	0	T	18477788	C	T	18477788	2	4	56	1	0	0	0	0	0	0	0	1	13157	813	29	3		3	RBBP9	20	18477788	Silent	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	16100620	18477788	44547732	50	9472										
RIN2	54453	broad.mit.edu	37	chr20	19955931	19955931	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cagctctgaatcacggccccCgtgccatggaggccggcagc	13	16	2	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr20:19955931C>A	ENST00000255006.6	+	8	1558	c.1409C>A	c.(1408-1410)cCg>cAg	p.P470Q	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Intron	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	421					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						TCACGGCCCCCGTGCCATGGA	0.687													6	23					8.12818e-05	8.52468e-05	1	1	0	A	19955931	C	A	19955931	3	1	56	1	0	0	0	0	1	0	0	0	13423	652	23	5	1288	5	RIN2	20	19955931	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	1478143	19955931	43069589	51	9473										
MC3R	4159	broad.mit.edu	37	chr20	54824623	54824623	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	actcatgcatgaagggggcaGtcaccatcaccattctcctg	9	13	4	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr20:54824623G>C	ENST00000243911.2	+	1	836	c.724G>C	c.(724-726)Gtc>Ctc	p.V242L		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	279					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			GAAGGGGGCAGTCACCATCAC	0.607													92	21					0	0	1	0	0	C	54824623	G	C	54824623	3	2	56	1	0	0	0	0	1	0	0	0	9414	1029	36	5	726	5	MC3R	20	54824623	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	34868692	54824623	8200897	52	9474										
BHLHE23	128408	broad.mit.edu	37	chr20	61637712	61637712	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gtaggggatgacggctcgcaGcccgtccagcgcgtcgttta	15	12	0	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr20:61637712G>A	ENST00000370346.2	-	1	675	c.367C>T	c.(367-369)Ctg>Ttg	p.L123L		NM_080606.3	NP_542173.1	Q8NDY6	BHE23_HUMAN	basic helix-loop-helix family, member e23	123	Helix-loop-helix motif.				transcription, DNA-dependent	nucleus	DNA binding			NS(1)	1						ACGGCTCGCAGCCCGTCCAGC	0.692													5	44					0	0	1	0	0	A	61637712	G	A	61637712	2	1	56	1	0	0	0	0	0	0	0	1	1421	962	34	3		3	BHLHE23	20	61637712	Silent	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	6813089	61637712	1387808	53	9475										
TMPRSS15	5651	broad.mit.edu	37	chr21	19732106	19732106	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tgcttgatcctacaccttcaTaaatatctaatatatctgta	3	9	3	1			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr21:19732106T>A	ENST00000284885.3	-	8	881	c.848A>T	c.(847-849)tAt>tTt	p.Y283F		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	283	CUB 1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TACACCTTCATAAATATCTAA	0.259													7	20					0	0	1	0	0	A	19732106	T	A	19732106	3	1	56	1	0	0	0	0	1	0	0	0	16305	1406	49	4	2283	4	TMPRSS15	21	19732106	Missense_Mutation	SNP	T	TCGA-QM-A5NM-01A-11D-A28R-08		19732106	28397789	54	9476										
KRTAP10-8	386681	broad.mit.edu	37	chr21	46032537	46032537	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tgcccatctgctgcaagcccAtctgctgtgtgcctgtctgc	10	15	3	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr21:46032537A>C	ENST00000334662.2	+	1	542	c.520A>C	c.(520-522)Atc>Ctc	p.I174L	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	174	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						CTGCAAGCCCATCTGCTGTGT	0.622													176	238					0	0	1	0	0	C	46032537	A	C	46032537	3	2	56	1	0	0	0	0	1	0	0	0	8557	217	8	4	522	4	KRTAP10-8	21	46032537	Missense_Mutation	SNP	A	TCGA-QM-A5NM-01A-11D-A28R-08	26300431	46032537	2097358	55	9477										
SBF1	6305	broad.mit.edu	37	chr22	50898502	50898502	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	gtagtcgcgacagcaagcccTttccaccaggctgctcatgg	11	14	1	0			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chr22:50898502T>C	ENST00000380817.2	-	26	3553	c.3370A>G	c.(3370-3372)Agg>Ggg	p.R1124G	SBF1_ENST00000390679.3_Missense_Mutation_p.R1124G|SBF1_ENST00000348911.6_Missense_Mutation_p.R1125G	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	1124	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCAAGCCCTTTCCACCAGG	0.672													55	5					0	0	1	0	0	C	50898502	T	C	50898502	3	2	56	1	0	0	0	0	1	0	0	0	13910	1608	56	4	2375	4	SBF1	22	50898502	Missense_Mutation	SNP	T	TCGA-QM-A5NM-01A-11D-A28R-08		50898502	406064	56	9478										
BCOR	54880	broad.mit.edu	37	chrX	39933118	39933118	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	tttcagatctatagatagcaCaaccatttcctggaggagat	8	8	2	3			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chrX:39933118C>T	ENST00000342274.4	-	4	1843	c.1481G>A	c.(1480-1482)tGt>tAt	p.C494Y	BCOR_ENST00000378444.4_Missense_Mutation_p.C494Y|BCOR_ENST00000378455.4_Missense_Mutation_p.C494Y|BCOR_ENST00000397354.3_Missense_Mutation_p.C494Y	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	494					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						ATAGATAGCACAACCATTTCC	0.522			"F, N, S, T"	RARA	"retinoblastoma, AML, APL(translocation)"		oculo-facio-cardio-dental genetic						10	33					0	0	1	0	0	T	39933118	C	T	39933118	3	4	56	1	0	0	0	0	1	0	0	0	1384	478	17	3	3834	3	BCOR	23	39933118	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08		39933118	115337442	57	9479										
MUM1L1	139221	broad.mit.edu	37	chrX	105449630	105449630	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	aaattgaagccattgctgccTcattaggactacagtcagag	9	9	2	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chrX:105449630T>C	ENST00000337685.2	+	5	990	c.205T>C	c.(205-207)Tca>Cca	p.S69P	MUM1L1_ENST00000372552.1_Missense_Mutation_p.S69P|MUM1L1_ENST00000357175.2_Missense_Mutation_p.S69P	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	69										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CATTGCTGCCTCATTAGGACT	0.388													7	27					0	0	1	0	0	C	105449630	T	C	105449630	3	2	56	1	0	0	0	0	1	0	0	0	10033	1551	54	4	207	4	MUM1L1	23	105449630	Missense_Mutation	SNP	T	TCGA-QM-A5NM-01A-11D-A28R-08	65516512	105449630	49820930	58	9480										
UPF3B	0	broad.mit.edu	37	chrX	118971901	118971901	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	catagcgctccttctgcctaCggcgctcttcttcttgccgc	8	17	4	0	rs143538947	byFrequency	TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chrX:118971901C>T	ENST00000276201.2	-	10	1190	c.1121G>A	c.(1120-1122)cGt>cAt	p.R374H	UPF3B_ENST00000345865.2_Missense_Mutation_p.R361H	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	374	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						CTTCTGCCTACGGCGCTCTTC	0.463													4	141					0	0	1	0	0	T	118971901	C	T	118971901	3	4	56	1	0	0	0	0	1	0	0	0	17065	536	19	1	338	1	UPF3B	23	118971901	Missense_Mutation	SNP	C	TCGA-QM-A5NM-01A-11D-A28R-08	13522271	118971901	36298659	59	9481										
FLNA	0	broad.mit.edu	37	chrX	153588159	153588159	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.05	3	1	0.67487091222031	1.31224899598394	0.542999584545077	1	1	0	cgccacggtcctgaacgtagGtctccgtcaggttgcctgag	13	13	2	2			TCGA-QM-A5NM-01A-11D-A28R-08	TCGA-QM-A5NM-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7aa385ed-8791-4ca0-8356-2e687ed33bc9	a8d35bbb-deef-4ead-b501-a8ac2c36b976	g.chrX:153588159G>T	ENST00000422373.1	-	23	4168	c.3920C>A	c.(3919-3921)aCc>aAc	p.T1307N	FLNA_ENST00000360319.4_Missense_Mutation_p.T1307N|FLNA_ENST00000369850.3_Missense_Mutation_p.T1307N|FLNA_ENST00000344736.4_Missense_Mutation_p.T1307N	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1307					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGAACGTAGGTCTCCGTCAG	0.652													25	101					2.79863e-10	3.16687e-10	1	1	0	T	153588159	G	T	153588159	3	4	56	1	0	0	0	0	1	0	0	0	5965	1261	44	5	4127	5	FLNA	23	153588159	Missense_Mutation	SNP	G	TCGA-QM-A5NM-01A-11D-A28R-08	34616258	153588159	1682401	60	9482										
MMEL1	79258	broad.mit.edu	37	chr1	2541172	2541172	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gctgtatcttgagttggtctCagggatcacgtggcgccgca	14	10	3	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:2541172C>T	ENST00000288709.6	-	5	604	c.364G>A	c.(364-366)Gag>Aag	p.E122K	MMEL1_ENST00000378412.3_Missense_Mutation_p.E131K|MMEL1_ENST00000502556.1_Missense_Mutation_p.E131K	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	131					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GAGTTGGTCTCAGGGATCACG	0.617													14	41					0	0	1	0	0	T	2541172	C	T	2541172	3	4	57	1	0	0	0	0	1	0	0	0	9693	835	29	3	2028	3	MMEL1	1	2541172	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08		2541172	246709449	1	9483										
CHD5	26038	broad.mit.edu	37	chr1	6228223	6228223	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ccctcacctctttcttcttcCgcttccctttacacttgttt	2	17	4	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:6228223C>T	ENST00000262450.3	-	2	293	c.194G>A	c.(193-195)cGg>cAg	p.R65Q	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	65	Lys-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTTCTTCTTCCGCTTCCCTTT	0.592													18	79					0	0	1	0	0	T	6228223	C	T	6228223	3	4	57	1	0	0	0	0	1	0	0	0	3350	652	23	1	5830	1	CHD5	1	6228223	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	3687051	6228223	243022398	2	9484										
RERE	473	broad.mit.edu	37	chr1	8684426	8684426	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gtgtttggcctccgactctcGatatacacacagtctttaaa	7	11	2	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:8684426G>C	ENST00000337907.3	-	4	973	c.339C>G	c.(337-339)atC>atG	p.I113M	RERE_ENST00000400907.2_Missense_Mutation_p.I113M|RERE_ENST00000400908.2_Missense_Mutation_p.I113M	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	113	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TCCGACTCTCGATATACACAC	0.368													17	61					0	0	1	0	0	C	8684426	G	C	8684426	3	2	57	1	0	0	0	0	1	0	0	0	13282	1048	37	2	4445	2	RERE	1	8684426	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	2456203	8684426	240566195	3	9485										
EPHB2	2048	broad.mit.edu	37	chr1	23232558	23232558	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	agtgcgggagtttgccaaggAaattgacatctcctgtgtca	12	8	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:23232558A>G	ENST00000400191.3	+	10	1862	c.1844A>G	c.(1843-1845)gAa>gGa	p.E615G	EPHB2_ENST00000374632.3_Missense_Mutation_p.E616G|EPHB2_ENST00000374627.1_Missense_Mutation_p.E610G|EPHB2_ENST00000374630.3_Missense_Mutation_p.E615G	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	615					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TTTGCCAAGGAAATTGACATC	0.532													18	15					0	0	1	0	0	G	23232558	A	G	23232558	3	3	57	1	0	0	0	0	1	0	0	0	5203	246	9	4	1885	4	EPHB2	1	23232558	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	14548132	23232558	226018063	4	9486										
FRRS1	391059	broad.mit.edu	37	chr1	100181217	100181217	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	acagttgtggtgaacatgagCatccgatgcacctgcaaggt	12	9	0	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:100181217C>T	ENST00000414213.1	-	12	1849	c.1248G>A	c.(1246-1248)atG>atA	p.M416I	FRRS1_ENST00000287474.5_Missense_Mutation_p.M416I			Q6ZNA5	FRRS1_HUMAN	ferric-chelate reductase 1	416	Cytochrome b561.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	26		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		TGAACATGAGCATCCGATGCA	0.418													16	16					0	0	1	0	0	T	100181217	C	T	100181217	3	4	57	1	0	0	0	0	1	0	0	0	6094	710	25	3	656	3	FRRS1	1	100181217	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	76948659	100181217	149069404	5	9487										
COL11A1	1301	broad.mit.edu	37	chr1	103352425	103352425	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ttcgggctggattggtctgaGtacccattggaaatttcata	11	7	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:103352425G>A	ENST00000358392.2	-	63	5149	c.4832C>T	c.(4831-4833)aCt>aTt	p.T1611I	COL11A1_ENST00000353414.4_Missense_Mutation_p.T1560I|COL11A1_ENST00000512756.1_Missense_Mutation_p.T1483I|COL11A1_ENST00000370096.3_Missense_Mutation_p.T1599I	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1599	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATTGGTCTGAGTACCCATTGG	0.403													12	38					0	0	1	0	0	A	103352425	G	A	103352425	3	1	57	1	0	0	0	0	1	0	0	0	3690	1029	36	3	644	3	COL11A1	1	103352425	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	3171208	103352425	145898196	6	9488										
CELSR2	1952	broad.mit.edu	37	chr1	109801533	109801533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cctcctcctccgtgctcttcCggcccatccaccccgtcgga	7	22	1	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:109801533C>T	ENST00000271332.3	+	2	3851	c.3790C>T	c.(3790-3792)Cgg>Tgg	p.R1264W		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1264	EGF-like 1; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGTGCTCTTCCGGCCCATCCA	0.697													9	17					0	0	1	0	0	T	109801533	C	T	109801533	3	4	57	1	0	0	0	0	1	0	0	0	3244	643	23	1	3796	1	CELSR2	1	109801533	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	6449108	109801533	139449088	7	9489										
ZBTB7B	51043	broad.mit.edu	37	chr1	154987310	154987312	+	In_Frame_Del	DEL	CTT	CTT	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ctagctgcctgtagccactaCttcaagaagcttttcactga							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:154987310_154987312delCTT	ENST00000368426.3	+	3	311_313	c.174_176delCTT	c.(172-177)tac>ta	p.YF58del	ZBTB7B_ENST00000292176.2_In_Frame_Del_p.YF58del|ZBTB7B_ENST00000417934.2_In_Frame_Del_p.YF92del|ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000535420.1_In_Frame_Del_p.YF58del	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	58	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTAGCCACTACTTCAAGAAGCTT	0.65													232	51	---	---	---	---						-	154987312	CTT	-	154987310	7	5	57	1	0	1	0	1	0	0	0	0	17612	576	20	0	176	0	ZBTB7B	1	154987310	In_Frame_Del	DEL	CTT	TCGA-QN-A5NN-01A-11D-A28R-08	45185777	154987310	94263311	8	9490										
KIF14	9928	broad.mit.edu	37	chr1	200522651	200522653	+	In_Frame_Del	DEL	TTC	TTC	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cttgatttagattgttggtgTtcttctttggtattttgatt							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:200522651_200522653delTTC	ENST00000367350.4	-	30	5248_5250	c.4810_4812delGAA	c.(4810-4812)del	p.E1604del		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1604	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						ATTGTTGGTGTTCTTCTTTGGTA	0.419													13	29	---	---	---	---						-	200522653	TTC	-	200522651	7	5	57	1	0	1	0	1	0	0	0	0	8317	1722	60	0	138	0	KIF14	1	200522651	In_Frame_Del	DEL	TTC	TCGA-QN-A5NN-01A-11D-A28R-08	45535341	200522651	48727970	9	9491										
TARBP1	6894	broad.mit.edu	37	chr1	234541826	234541826	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	actgcagcacaactataaggGcttgcttcagaattagtttc	8	9	1	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:234541826G>C	ENST00000040877.1	-	24	3811	c.3812C>G	c.(3811-3813)gCc>gGc	p.A1271G	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1271					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AACTATAAGGGCTTGCTTCAG	0.363													13	46					0	0	1	0	0	C	234541826	G	C	234541826	3	2	57	1	0	0	0	0	1	0	0	0	15611	1203	42	5	1081	5	TARBP1	1	234541826	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	34019175	234541826	14708795	10	9492										
OR14I1	401994	broad.mit.edu	37	chr1	248844931	248844931	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cgactctgtcctgaagggatTctgagcaccgttgagaagat	12	9	2	4			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr1:248844931T>G	ENST00000342623.3	-	1	698	c.675A>C	c.(673-675)agA>agC	p.R225S		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						CTGAAGGGATTCTGAGCACCG	0.488													16	44					0	0	1	0	0	G	248844931	T	G	248844931	3	3	57	1	0	0	0	0	1	0	0	0	10994	1780	62	4	264	4	OR14I1	1	248844931	Missense_Mutation	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	14303105	248844931	405690	11	9493										
GPR39	2863	broad.mit.edu	37	chr2	133174753	133174753	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atcttcgtgatgggccttctGgggaacagcgccaccattcg	12	12	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr2:133174753G>A	ENST00000329321.3	+	1	607	c.138G>A	c.(136-138)ctG>ctA	p.L46L		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	46						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGGGCCTTCTGGGGAACAGCG	0.517													60	11					0	0	1	0	0	A	133174753	G	A	133174753	2	1	57	1	0	0	0	0	0	0	0	1	6732	1335	47	3		3	GPR39	2	133174753	Silent	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		133174753	110024620	12	9494										
FBLN2	2199	broad.mit.edu	37	chr3	13663415	13663415	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atgcgcacaggaagtgcgtgGgtaagccagggccccgcctg	16	12	0	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr3:13663415G>A	ENST00000404922.3	+	9	2415	c.2296_splice	c.e9+1	p.D766_splice	FBLN2_ENST00000492059.1_Splice_Site_p.D766_splice|FBLN2_ENST00000535798.1_Intron|FBLN2_ENST00000295760.7_Intron	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	764	EGF-like 4; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GAAGTGCGTGGGTAAGCCAGG	0.617													9	14					0	0	1	0	0	A	13663415	G	A	13663415	5	1	57	1	0	0	0	0	0	0	1	0	5731	1246	43	3	1016	3	FBLN2	3	13663415	Splice_Site	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		13663415	184359015	13	9495										
GRIP2	80852	broad.mit.edu	37	chr3	14552718	14552718	+	RNA	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cttcagcttcaccaggtcctCgcactgccgcaggatttgca	9	15	2	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr3:14552718C>T	ENST00000273083.3	-	0	1952							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						ACCAGGTCCTCGCACTGCCGC	0.617													12	28					0	0	1	0	0	T	14552718	C	T	14552718	1	4	57	0	1	0	0	0	0	0	0	0	6828	893	31	1		1	GRIP2	3	14552718	RNA	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	889303	14552718	183469712	14	9496										
GNAI2	2771	broad.mit.edu	37	chr3	50290582	50290582	+	Frame_Shift_Del	DEL	T	T	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tgcaggcctgctttggccgcTcaagggaataccagctcaac							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr3:50290582delT	ENST00000313601.6	+	4	814	c.430delT	c.(430-432)cafs	p.S144fs	GNAI2_ENST00000422163.1_Frame_Shift_Del_p.S128fs|GNAI2_ENST00000451956.1_Frame_Shift_Del_p.S107fs|GNAI2_ENST00000440628.1_Frame_Shift_Del_p.S92fs|GNAI2_ENST00000536647.1_Frame_Shift_Del_p.S63fs|GNAI2_ENST00000491100.1_3'UTR|GNAI2_ENST00000266027.5_Frame_Shift_Del_p.S128fs	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	144					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		CTTTGGCCGCTCAAGGGAATA	0.657													13	232	---	---	---	---						-	50290582	T	-	50290582	7	5	57	1	0	1	0	1	0	0	0	0	6546	1551	54	0	455	0	GNAI2	3	50290582	Frame_Shift_Del	DEL	T	TCGA-QN-A5NN-01A-11D-A28R-08	35737864	50290582	147731848	15	9497										
DNAH1	25981	broad.mit.edu	37	chr3	52366244	52366244	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	acccttgcatgttcgcacaaCgtgtggtccaggccaacgcc	10	15	0	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr3:52366244C>T	ENST00000420323.2	+	8	1381	c.1120C>T	c.(1120-1122)Cgt>Tgt	p.R374C		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	374	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTTCGCACAACGTGTGGTCCA	0.602													12	14					0	0	1	0	0	T	52366244	C	T	52366244	3	4	57	1	0	0	0	0	1	0	0	0	4625	536	19	1	1146	1	DNAH1	3	52366244	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	2075662	52366244	145656186	16	9498										
PARP9	83666	broad.mit.edu	37	chr3	122247220	122247220	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tgatgtagagattaatcaacAgggctgccacttgcgaatcc	10	9	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr3:122247220A>T	ENST00000360356.2	-	11	2783	c.2556T>A	c.(2554-2556)ccT>ccA	p.P852P	PARP9_ENST00000477522.2_Silent_p.P817P|PARP9_ENST00000471785.1_Silent_p.P817P|PARP9_ENST00000492382.1_Silent_p.P397P	NM_001146102.1|NM_031458.2	NP_001139574.1|NP_113646.2	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	852					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		ATTAATCAACAGGGCTGCCAC	0.453													28	48					0	0	1	0	0	T	122247220	A	T	122247220	2	4	57	1	0	0	0	0	0	0	0	1	11512	175	7	4		4	PARP9	3	122247220	Silent	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	69880976	122247220	75775210	17	9499										
CLCN2	1181	broad.mit.edu	37	chr3	184071184	184071184	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tgccaccacctgtgaacgctCgatggagcccagcagaatca	10	14	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr3:184071184C>T	ENST00000265593.4	-	17	2053	c.1882G>A	c.(1882-1884)Gag>Aag	p.E628K	CLCN2_ENST00000344937.7_Missense_Mutation_p.E611K|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000434054.2_Missense_Mutation_p.E584K|CLCN2_ENST00000423355.2_3'UTR|CLCN2_ENST00000457512.1_Missense_Mutation_p.E628K	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	628	CBS 1.					chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TGTGAACGCTCGATGGAGCCC	0.632													14	35					0	0	1	0	0	T	184071184	C	T	184071184	3	4	57	1	0	0	0	0	1	0	0	0	3486	893	31	1	846	1	CLCN2	3	184071184	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	61823964	184071184	13951246	18	9500										
WFS1	7466	broad.mit.edu	37	chr4	6304157	6304157	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atggcgccgtgaagttcgccTtcgacttctttttcttccca	8	13	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr4:6304157T>C	ENST00000226760.1	+	8	2805	c.2635T>C	c.(2635-2637)Ttc>Ctc	p.F879L	WFS1_ENST00000503569.1_Missense_Mutation_p.F879L	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	879	Poly-Phe.				endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		GAAGTTCGCCTTCGACTTCTT	0.622													33	12					0	0	1	0	0	C	6304157	T	C	6304157	3	2	57	1	0	0	0	0	1	0	0	0	17419	1609	56	4	2661	4	WFS1	4	6304157	Missense_Mutation	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08		6304157	184850119	19	9501										
CDH10	1008	broad.mit.edu	37	chr5	24537572	24537572	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cattgatatcatgaattttgAtcacaaactctgactctggc	6	9	4	4			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr5:24537572A>C	ENST00000264463.4	-	3	950	c.443T>G	c.(442-444)aTc>aGc	p.I148S		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	148	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATGAATTTTGATCACAAACTC	0.418										HNSCC(23;0.051)			27	108					0	0	1	0	0	C	24537572	A	C	24537572	3	2	57	1	0	0	0	0	1	0	0	0	3118	333	12	4	1963	4	CDH10	5	24537572	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		24537572	156377688	20	9502										
SLC45A2	51151	broad.mit.edu	37	chr5	33947401	33947401	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ggaagagcccaataaatcccGtccccaggccaaacagcaaa	8	14	0	1	rs149980670		TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr5:33947401G>A	ENST00000382102.3	-	6	1292	c.1235C>T	c.(1234-1236)aCg>aTg	p.T412M	SLC45A2_ENST00000342059.3_Missense_Mutation_p.T353M|SLC45A2_ENST00000296589.4_Missense_Mutation_p.T412M	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	412					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane		p.T412M(1)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						AATAAATCCCGTCCCCAGGCC	0.488													8	182					0	0	1	0	0	A	33947401	G	A	33947401	3	1	57	1	0	0	0	0	1	0	0	0	14695	1145	40	1	380	1	SLC45A2	5	33947401	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	9409829	33947401	146967859	21	9503										
ARL15	54622	broad.mit.edu	37	chr5	53467719	53467719	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aaccaggtcatattctggtcGtgcaggtggtggtcccttgc	13	10	2	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr5:53467719G>A	ENST00000504924.1	-	2	181	c.88C>T	c.(88-90)Cga>Tga	p.R30*	ARL15_ENST00000507646.2_Nonsense_Mutation_p.R30*|ARL15_ENST00000502271.1_Intron|ARL15_ENST00000510591.2_5'UTR	NM_019087.2	NP_061960.1	Q9NXU5	ARL15_HUMAN	ADP-ribosylation factor-like 15	30							GTP binding			endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		Lung NSC(810;0.000779)				TATTCTGGTCGTGCAGGTGGT	0.463													25	14					0	0	1	0	0	A	53467719	G	A	53467719	4	1	57	1	0	0	0	0	0	1	0	0	928	1153	40	1	542	1	ARL15	5	53467719	Nonsense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	19520318	53467719	127447541	22	9504										
PIK3R1	5295	broad.mit.edu	37	chr5	67589632	67589643	+	In_Frame_Del	DEL	ATTATATGAAGA	ATTATATGAAGA	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aaaagtcgagaatatgatagAttatatgaagaatatacccg							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr5:67589632_67589643delATTATATGAAGA	ENST00000521381.1	+	11	2011_2022	c.1395_1406delATTATATGAAGA	c.(1393-1407)aga>ag	p.RLYEE465del	PIK3R1_ENST00000396611.1_In_Frame_Del_p.RLYEE465del|PIK3R1_ENST00000523872.1_In_Frame_Del_p.RLYEE102del|PIK3R1_ENST00000336483.5_In_Frame_Del_p.RLYEE195del|PIK3R1_ENST00000274335.5_In_Frame_Del_p.RLYEE465del|PIK3R1_ENST00000320694.8_In_Frame_Del_p.RLYEE165del|PIK3R1_ENST00000521657.1_In_Frame_Del_p.RLYEE465del	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	465					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.Y463_L466del(1)|p.D434_Q475del(1)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AATATGATAGATTATATGAAGAATATACCCGC	0.288			"Mis, F, O"		"gliobastoma, ovarian, colorectal"					TCGA GBM(4;<1E-08)			19	26	---	---	---	---						-	67589643	ATTATATGAAGA	-	67589632	7	5	57	1	0	1	0	1	0	0	0	0	11965	330	12	0	1563	0	PIK3R1	5	67589632	In_Frame_Del	DEL	ATTATATGAAGA	TCGA-QN-A5NN-01A-11D-A28R-08	14121913	67589632	113325628	23	9505										
FCHO2	115548	broad.mit.edu	37	chr5	72364497	72364497	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cccaggccattcagcccaccTgtaacttccaacaccagccc	5	20	1	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr5:72364497T>G	ENST00000430046.2	+	19	1586	c.1470T>G	c.(1468-1470)ccT>ccG	p.P490P	FCHO2_ENST00000341845.6_Silent_p.P490P|FCHO2_ENST00000512348.1_Silent_p.P457P	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	490	Ser-rich.									cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		TCAGCCCACCTGTAACTTCCA	0.413													38	23					0	0	1	0	0	G	72364497	T	G	72364497	2	3	57	1	0	0	0	0	0	0	0	1	5820	1567	55	4		4	FCHO2	5	72364497	Silent	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	4774865	72364497	108550763	24	9506										
PCDHGA2	0	broad.mit.edu	37	chr5	140718978	140718978	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aaaaatcagtgaaaccactaCgccaggattccggattcctc	7	12	1	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr5:140718978C>T	ENST00000394576.2	+	1	440	c.440C>T	c.(439-441)aCg>aTg	p.T147M	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACCACTACGCCAGGATTC	0.453													72	57					0	0	1	0	0	T	140718978	C	T	140718978	3	4	57	1	0	0	0	0	1	0	0	0	11600	536	19	1	442	1	PCDHGA2	5	140718978	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	68354481	140718978	40196282	25	9507										
PGBD1	84547	broad.mit.edu	37	chr6	28264666	28264666	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gtcacatctgagtctgactcGgaggaacctctgtgggaact	12	10	4	2	rs115946459	by1000genomes	TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr6:28264666G>C	ENST00000405948.2	+	5	1136	c.716G>C	c.(715-717)cGg>cCg	p.R239P	PGBD1_ENST00000259883.3_Missense_Mutation_p.R239P	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	239					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity	p.R239Q(1)		endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						AGTCTGACTCGGAGGAACCTC	0.507													15	83					0	0	1	0	0	C	28264666	G	C	28264666	3	2	57	1	0	0	0	0	1	0	0	0	11827	1116	39	5	730	5	PGBD1	6	28264666	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		28264666	142850401	26	9508										
HLA-DQA1	3117	broad.mit.edu	37	chr6	32610504	32610504	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cttcatcatccaaggcctgcGttcagttggtgcttccagac	9	13	3	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr6:32610504G>A	ENST00000343139.5	+	4	833	c.731G>A	c.(730-732)cGt>cAt	p.R244H	HLA-DQA1_ENST00000395363.1_Missense_Mutation_p.R244H|HLA-DQA1_ENST00000374949.2_Missense_Mutation_p.R244H	NM_002122.3	NP_002113.2	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ alpha 1	243					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						CAAGGCCTGCGTTCAGTTGGT	0.537													65	122					0	0	1	0	0	A	32610504	G	A	32610504	3	1	57	1	0	0	0	0	1	0	0	0	7244	1145	40	1	745	1	HLA-DQA1	6	32610504	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	4345838	32610504	138504563	27	9509										
CRISP1	167	broad.mit.edu	37	chr6	49814267	49814267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cagtagttatgtcatcatccGttgttgtccattctccatgt	7	10	3	0	rs139194307	byFrequency	TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr6:49814267G>A	ENST00000335847.4	-	5	502	c.401C>T	c.(400-402)aCg>aTg	p.T134M	CRISP1_ENST00000505118.1_Missense_Mutation_p.T134M|CRISP1_ENST00000536021.1_Missense_Mutation_p.T134M|CRISP1_ENST00000355791.2_Missense_Mutation_p.T134M|CRISP1_ENST00000507853.1_Missense_Mutation_p.T134M|CRISP1_ENST00000329411.5_Missense_Mutation_p.T134M	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	134					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					GTCATCATCCGTTGTTGTCCA	0.398													14	67					0	0	1	0	0	A	49814267	G	A	49814267	3	1	57	1	0	0	0	0	1	0	0	0	3902	1145	40	1	364	1	CRISP1	6	49814267	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	17203763	49814267	121300800	28	9510										
IMPG1	3617	broad.mit.edu	37	chr6	76712656	76712656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aggtagaccatgctctgctcCgtccactgtctcaagctggg	11	13	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr6:76712656C>T	ENST00000369950.3	-	12	1459	c.1270G>A	c.(1270-1272)Gga>Aga	p.G424R	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	424					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGCTCTGCTCCGTCCACTGTC	0.438													9	8					0	0	1	0	0	T	76712656	C	T	76712656	3	4	57	1	0	0	0	0	1	0	0	0	7771	661	23	1	1147	1	IMPG1	6	76712656	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	26898389	76712656	94402411	29	9511										
ROS1	6098	broad.mit.edu	37	chr6	117686852	117686852	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gcatttccttcaatcctaaaTgaagactcttgaacagaatc	5	10	2	4			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr6:117686852T>A	ENST00000368508.3	-	19	3063	c.2865A>T	c.(2863-2865)tcA>tcT	p.S955S	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Silent_p.S950S	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	955	Fibronectin type-III 4.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CAATCCTAAATGAAGACTCTT	0.388			T	"GOPC, SDC4, SLC34A2, EZR, LRIG3"	"glioblastoma, NSCLC"								21	4					0	0	1	0	0	A	117686852	T	A	117686852	2	1	57	1	0	0	0	0	0	0	0	1	13582	1451	51	4		4	ROS1	6	117686852	Silent	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	40974196	117686852	53428215	30	9512										
CARD11	84433	broad.mit.edu	37	chr7	2962374	2962374	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aacgggacactctgcctctcGcctcggatgcagccttctag	10	15	3	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr7:2962374G>A	ENST00000396946.4	-	17	2566	c.2163C>T	c.(2161-2163)ggC>ggT	p.G721G		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	721	PDZ.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCTGCCTCTCGCCTCGGATGC	0.617			Mis		DLBCL								21	45					0	0	1	0	0	A	2962374	G	A	2962374	2	1	57	1	0	0	0	0	0	0	0	1	2663	1074	38	1		1	CARD11	7	2962374	Silent	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		2962374	156176289	31	9513										
ABCB5	340273	broad.mit.edu	37	chr7	20682948	20682948	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tcagttttggcacaggacatCggctggtttgatagctgtga	13	7	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr7:20682948C>T	ENST00000404938.2	+	6	1108	c.456C>T	c.(454-456)atC>atT	p.I152I		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	336	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CACAGGACATCGGCTGGTTTG	0.398													5	37					0	0	1	0	0	T	20682948	C	T	20682948	2	4	57	1	0	0	0	0	0	0	0	1	44	874	31	1		1	ABCB5	7	20682948	Silent	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	17720574	20682948	138455715	32	9514										
SND1	27044	broad.mit.edu	37	chr7	127721495	127721495	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cgatctgctagctacaagccCgtgtttgtgactgagatcac	10	11	2	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr7:127721495C>T	ENST00000354725.3	+	18	2246	c.2052C>T	c.(2050-2052)ccC>ccT	p.P684P		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	684					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						GCTACAAGCCCGTGTTTGTGA	0.597													17	19					0	0	1	0	0	T	127721495	C	T	127721495	2	4	57	1	0	0	0	0	0	0	0	1	14897	639	23	1		1	SND1	7	127721495	Silent	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	107038547	127721495	31417168	33	9515										
ZNF862	643641	broad.mit.edu	37	chr7	149557897	149557897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tcgttccagagatctccagcGacctcatggccaacatggag	10	13	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr7:149557897G>A	ENST00000223210.4	+	7	1893	c.1648G>A	c.(1648-1650)Gac>Aac	p.D550N		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						GATCTCCAGCGACCTCATGGC	0.512													34	43					0	0	1	0	0	A	149557897	G	A	149557897	3	1	57	1	0	0	0	0	1	0	0	0	18237	1058	37	1	1674	1	ZNF862	7	149557897	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	21836402	149557897	9580766	34	9516										
DLGAP2	9228	broad.mit.edu	37	chr8	1616711	1616711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	caacaaggccatgaacctcgCgctggaaacggccgctgccc	11	16	0	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:1616711C>T	ENST00000421627.2	+	6	1921	c.1787C>T	c.(1786-1788)gCg>gTg	p.A596V		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	675					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ATGAACCTCGCGCTGGAAACG	0.672													11	10					0	0	1	0	0	T	1616711	C	T	1616711	3	4	57	1	0	0	0	0	1	0	0	0	4588	768	27	1	1805	1	DLGAP2	8	1616711	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08		1616711	144747311	35	9517										
NEFM	4741	broad.mit.edu	37	chr8	24771770	24771770	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cgcgtacgaccaggagatccGcgagctgcgcgccaccctgg	14	16	0	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:24771770G>A	ENST00000221166.5	+	1	1246	c.464G>A	c.(463-465)cGc>cAc	p.R155H	NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000518131.1_Missense_Mutation_p.R155H|GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000437366.2_Missense_Mutation_p.R155H			P07197	NFM_HUMAN	neurofilament, medium polypeptide	155	Coil 1B.|Rod.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CAGGAGATCCGCGAGCTGCGC	0.652													20	9					0	0	1	0	0	A	24771770	G	A	24771770	3	1	57	1	0	0	0	0	1	0	0	0	10362	1087	38	1	466	1	NEFM	8	24771770	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	23155059	24771770	121592252	36	9518										
STMN4	81551	broad.mit.edu	37	chr8	27099994	27099994	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	acaccagcgggagctccttcAtcttctctttgtaggctgcg	10	13	3	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:27099994A>G	ENST00000350889.4	-	3	142	c.29T>C	c.(28-30)aTg>aCg	p.M10T	STMN4_ENST00000522908.1_Missense_Mutation_p.M10T|STMN4_ENST00000265770.7_Missense_Mutation_p.M10T|STMN4_ENST00000523048.1_Missense_Mutation_p.M10T|STMN4_ENST00000519614.1_Missense_Mutation_p.M10T|STMN4_ENST00000519997.1_Start_Codon_SNP_p.M1T	NM_030795.2	NP_110422.2	Q9H169	STMN4_HUMAN	stathmin-like 4	10					intracellular signal transduction					endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	11		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		GAGCTCCTTCATCTTCTCTTT	0.572													15	14					0	0	1	0	0	G	27099994	A	G	27099994	3	3	57	1	0	0	0	0	1	0	0	0	15366	217	8	4	641	4	STMN4	8	27099994	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	2328224	27099994	119264028	37	9519										
LRRCC1	85444	broad.mit.edu	37	chr8	86025226	86025226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atattgatctacatagtaatCgtatagatagtatccatcac	5	7	2	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:86025226C>T	ENST00000414626.2	+	3	1265	c.376C>T	c.(376-378)Cgt>Tgt	p.R126C	LRRCC1_ENST00000360375.3_Missense_Mutation_p.R146C			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	146					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						ACATAGTAATCGTATAGATAG	0.358													33	25					0	0	1	0	0	T	86025226	C	T	86025226	3	4	57	1	0	0	0	0	1	0	0	0	9070	884	31	1	450	1	LRRCC1	8	86025226	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	58925232	86025226	60338796	38	9520										
COL14A1	7373	broad.mit.edu	37	chr8	121238999	121238999	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ccagtctatggggggaagacTgaggaggtgagttttctgaa	16	5	2	4			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:121238999T>A	ENST00000297848.3	+	16	2268	c.1998T>A	c.(1996-1998)acT>acA	p.T666T	COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000247781.3_Silent_p.T571T|COL14A1_ENST00000309791.4_Silent_p.T666T|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	666	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGGGGAAGACTGAGGAGGTGA	0.438													6	48					0	0	1	0	0	A	121238999	T	A	121238999	2	1	57	1	0	0	0	0	0	0	0	1	3694	1567	55	4		4	COL14A1	8	121238999	Silent	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	35213773	121238999	25125023	39	9521										
MTBP	27085	broad.mit.edu	37	chr8	121535576	121535576	+	Nonstop_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gaaaagacaagcaagaaatgAtacataatcattctctttaa	5	6	2	3			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:121535576A>G	ENST00000305949.1	+	22	2760	c.2715A>G	c.(2713-2715)tgA>tgG	p.*905W		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	0					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GCAAGAAATGATACATAATCA	0.269													21	110					0	0	1	0	0	G	121535576	A	G	121535576	4	3	57	1	0	0	0	0	0	0	0	0	9959	346	12	4	2801	4	MTBP	8	121535576	Nonstop_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	296577	121535576	24828446	40	9522										
KCNK9	51305	broad.mit.edu	37	chr8	140630989	140630989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gagcggcttcttctgcagggCacccttggtctgcagggcca	14	13	3	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:140630989C>T	ENST00000520439.1	-	2	700	c.637G>A	c.(637-639)Gcc>Acc	p.A213T	KCNK9_ENST00000303015.1_Missense_Mutation_p.A213T			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	213						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TTCTGCAGGGCACCCTTGGTC	0.567													26	159					0	0	1	0	0	T	140630989	C	T	140630989	3	4	57	1	0	0	0	0	1	0	0	0	8115	710	25	3	491	3	KCNK9	8	140630989	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	19095413	140630989	5733033	41	9523										
PLEC	5339	broad.mit.edu	37	chr8	145006361	145006361	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tccccagcattttggagctcCttgatcttcttctccttcag	6	14	4	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr8:145006361C>G	ENST00000322810.4	-	17	2599	c.2430G>C	c.(2428-2430)aaG>aaC	p.K810N	PLEC_ENST00000527096.1_Missense_Mutation_p.K696N|PLEC_ENST00000354958.2_Missense_Mutation_p.K651N|PLEC_ENST00000354589.3_Missense_Mutation_p.K673N|PLEC_ENST00000436759.2_Missense_Mutation_p.K700N|PLEC_ENST00000345136.3_Missense_Mutation_p.K673N|PLEC_ENST00000356346.3_Missense_Mutation_p.K659N|PLEC_ENST00000357649.2_Missense_Mutation_p.K677N|PLEC_ENST00000398774.2_Missense_Mutation_p.K641N	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	810	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TTTGGAGCTCCTTGATCTTCT	0.711													44	29					0	0	1	0	0	G	145006361	C	G	145006361	3	3	57	1	0	0	0	0	1	0	0	0	12099	680	24	5	11688	5	PLEC	8	145006361	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	4375372	145006361	1357661	42	9524										
AKR1C3	8644	broad.mit.edu	37	chr10	5141029	5141029	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tcaccaacagatgaaaatggAaaagtaatatttgacatagt	7	5	1	3			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr10:5141029A>G	ENST00000380554.3	+	4	1057	c.405A>G	c.(403-405)ggA>ggG	p.G135G	AKR1C3_ENST00000439082.2_Silent_p.G16G|AKR1C3_ENST00000605149.1_Silent_p.G112G	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	135					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	ATGAAAATGGAAAAGTAATAT	0.413													8	13					0	0	1	0	0	G	5141029	A	G	5141029	2	3	57	1	0	0	0	0	0	0	0	1	468	233	9	4		4	AKR1C3	10	5141029	Silent	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		5141029	130393718	43	9525										
CDHR1	92211	broad.mit.edu	37	chr10	85972083	85972083	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aggtgtttatcacactgctgGatgtcaatgaccacccccct	8	13	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr10:85972083G>T	ENST00000372117.3	+	15	1805	c.1702G>T	c.(1702-1704)Gat>Tat	p.D568Y	CDHR1_ENST00000440770.2_Missense_Mutation_p.D272Y|CDHR1_ENST00000332904.3_Missense_Mutation_p.D568Y	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	568	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CACACTGCTGGATGTCAATGA	0.517													46	95					4.01344e-20	4.35868e-20	1	1	0	T	85972083	G	T	85972083	3	4	57	1	0	0	0	0	1	0	0	0	3140	1174	41	2	1760	2	CDHR1	10	85972083	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	80831054	85972083	49562664	44	9526										
PKD2L1	9033	broad.mit.edu	37	chr10	102054719	102054719	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atgcacttgatgaaagtgctAaagttttccacttgggtccc	9	9	0	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr10:102054719A>G	ENST00000318222.3	-	8	1900	c.1518T>C	c.(1516-1518)ttT>ttC	p.F506F	PKD2L1_ENST00000353274.3_Silent_p.F506F|PKD2L1_ENST00000338519.3_Silent_p.F431F	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	506					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGAAAGTGCTAAAGTTTTCCA	0.542													13	32					0	0	1	0	0	G	102054719	A	G	102054719	2	3	57	1	0	0	0	0	0	0	0	1	12014	359	13	4		4	PKD2L1	10	102054719	Silent	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	16082636	102054719	33480028	45	9527										
PDZD7	79955	broad.mit.edu	37	chr10	102783751	102783751	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atgctctgagcccccgcgcaCgctgaagcccagcctccctg	10	19	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr10:102783751C>T	ENST00000370215.3	-	3	526	c.301G>A	c.(301-303)Gtg>Atg	p.V101M	PDZD7_ENST00000470414.1_Missense_Mutation_p.V101M	NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	101	PDZ 1.					cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CCCCCGCGCACGCTGAAGCCC	0.582													6	92					0	0	1	0	0	T	102783751	C	T	102783751	3	4	57	1	0	0	0	0	1	0	0	0	11750	536	19	1	1284	1	PDZD7	10	102783751	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	729032	102783751	32750996	46	9528										
DCHS1	8642	broad.mit.edu	37	chr11	6643541	6643541	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ggtgcagggctcaggccacaGccccccaggaaggctgtggc	16	14	1	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:6643541G>T	ENST00000299441.3	-	21	9777	c.9366C>A	c.(9364-9366)ggC>ggA	p.G3122G	RP11-732A19.5_ENST00000526456.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	3122					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGGCCACAGCCCCCCAGGA	0.662													6	5					2.0095e-06	2.02959e-06	1	1	0	T	6643541	G	T	6643541	2	4	57	1	0	0	0	0	0	0	0	1	4310	958	34	5		5	DCHS1	11	6643541	Silent	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		6643541	128362975	47	9529										
OR5I1	10798	broad.mit.edu	37	chr11	55703549	55703549	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gatgaaggattctgtatctgCaaaagtacagaaaaaataaa	8	4	2	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:55703549C>A	ENST00000301532.3	-	1	327	c.328G>T	c.(328-330)Gca>Tca	p.A110S		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TCTGTATCTGCAAAAGTACAG	0.438													9	22					3.09899e-07	3.16159e-07	1	1	0	A	55703549	C	A	55703549	3	1	57	1	0	0	0	0	1	0	0	0	11210	710	25	5	619	5	OR5I1	11	55703549	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	49060008	55703549	79302967	48	9530										
DAK	26007	broad.mit.edu	37	chr11	61105561	61105561	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cctcaagggccgggtggcacTgctgtcgggtgggggctctg	19	11	2	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:61105561T>G	ENST00000394900.3	+	3	381	c.152T>G	c.(151-153)cTg>cGg	p.L51R	DAK_ENST00000530057.1_3'UTR	NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	51	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						CGGGTGGCACTGCTGTCGGGT	0.687													42	32					0	0	1	0	0	G	61105561	T	G	61105561	3	3	57	1	0	0	0	0	1	0	0	0	4252	1580	55	4	158	4	DAK	11	61105561	Missense_Mutation	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	5402012	61105561	73900955	49	9531										
RNF121	55298	broad.mit.edu	37	chr11	71693851	71693851	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gttgttcccctctatttcacAgtgaagctgcactggtggag	11	10	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:71693851A>C	ENST00000361756.3	+	4	649	c.288A>C	c.(286-288)acA>acC	p.T96T	RNF121_ENST00000545854.1_Silent_p.T15T|RNF121_ENST00000533380.1_Intron|RNF121_ENST00000530137.1_Silent_p.T64T|RNF121_ENST00000490867.1_3'UTR|RNF121_ENST00000393713.3_Silent_p.T64T	NM_018320.4	NP_060790.2	Q9H920	RN121_HUMAN	ring finger protein 121	96						integral to membrane	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|urinary_tract(1)	13						TCTATTTCACAGTGAAGCTGC	0.512													25	78					0	0	1	0	0	C	71693851	A	C	71693851	2	2	57	1	0	0	0	0	0	0	0	1	13482	175	7	4		4	RNF121	11	71693851	Silent	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	10588290	71693851	63312665	50	9532										
ARAP1	116985	broad.mit.edu	37	chr11	72425328	72425328	+	Frame_Shift_Del	DEL	A	A	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gtggctggggaggggatgatAatgatggcagcaatgactcc							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:72425328delA	ENST00000359373.5	-	4	1399	c.548delT	c.(547-549)tafs	p.L183fs	ARAP1_ENST00000455638.2_Frame_Shift_Del_p.L183fs|ARAP1_ENST00000429686.1_5'UTR|ARAP1_ENST00000426523.1_5'UTR|ARAP1_ENST00000393609.3_Frame_Shift_Del_p.L183fs|ARAP1_ENST00000334211.8_5'UTR			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	183					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						AGGGGATGATAATGATGGCAG	0.592													2	4	---	---	---	---						-	72425328	A	-	72425328	7	5	57	1	0	1	0	1	0	0	0	0	835	372	13	0	3932	0	ARAP1	11	72425328	Frame_Shift_Del	DEL	A	TCGA-QN-A5NN-01A-11D-A28R-08	731477	72425328	62581188	51	9533										
OMP	4975	broad.mit.edu	37	chr11	76813927	76813927	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cagccgcagctggacatgccGctggtcctggaccagggcct	14	15	0	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:76813927G>A	ENST00000529803.1	+	1	42	c.42G>A	c.(40-42)ccG>ccA	p.P14P	CAPN5_ENST00000456580.2_Intron|CAPN5_ENST00000529629.1_Intron|CAPN5_ENST00000531028.1_Intron|CAPN5_ENST00000278559.3_Intron	NM_006189.1	NP_006180.1	P47874	OMP_HUMAN	olfactory marker protein	14					sensory perception of smell|synaptic transmission					endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						TGGACATGCCGCTGGTCCTGG	0.692													21	14					0	0	1	0	0	A	76813927	G	A	76813927	2	1	57	1	0	0	0	0	0	0	0	1	10914	1074	38	1		1	OMP	11	76813927	Silent	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	4388599	76813927	58192589	52	9534										
MMP1	4312	broad.mit.edu	37	chr11	102661492	102661492	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ccaggaaagtcatgtgctatCattttgggataacctggatc	10	8	2	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr11:102661492C>G	ENST00000315274.6	-	9	1309	c.1242G>C	c.(1240-1242)atG>atC	p.M414I	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	414	Hemopexin-like 3.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CATGTGCTATCATTTTGGGAT	0.383													28	19					0	0	1	0	0	G	102661492	C	G	102661492	3	3	57	1	0	0	0	0	1	0	0	0	9695	826	29	2	175	2	MMP1	11	102661492	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	25847565	102661492	32345024	53	9535										
SPATS2	65244	broad.mit.edu	37	chr12	49912901	49912901	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gaaggctgaacttctaaagaAgatgactcatgtggctgttc	11	7	2	4			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr12:49912901A>G	ENST00000553127.1	+	12	1457	c.944A>G	c.(943-945)aAg>aGg	p.K315R	SPATS2_ENST00000552918.1_Missense_Mutation_p.K315R|SPATS2_ENST00000321898.6_Missense_Mutation_p.K315R			Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	315						cytoplasm				breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(1)|prostate(1)|urinary_tract(4)	21						CTTCTAAAGAAGATGACTCAT	0.398													14	15					0	0	1	0	0	G	49912901	A	G	49912901	3	3	57	1	0	0	0	0	1	0	0	0	15074	72	3	4	978	4	SPATS2	12	49912901	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		49912901	83938994	54	9536										
LARP4	113251	broad.mit.edu	37	chr12	50834308	50834308	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	agcaactggtatatcactttCcagtcagacacagatgcaca	7	11	2	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr12:50834308C>G	ENST00000398473.2	+	7	838	c.726C>G	c.(724-726)ttC>ttG	p.F242L	LARP4_ENST00000522085.1_Missense_Mutation_p.F242L|LARP4_ENST00000518444.1_Missense_Mutation_p.F241L|LARP4_ENST00000429001.3_Missense_Mutation_p.F248L|LARP4_ENST00000347328.5_Missense_Mutation_p.F242L|LARP4_ENST00000293618.8_Missense_Mutation_p.F242L|LARP4_ENST00000518561.1_Missense_Mutation_p.F172L	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	242	RRM.						nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						ATATCACTTTCCAGTCAGACA	0.353													12	14					0	0	1	0	0	G	50834308	C	G	50834308	3	3	57	1	0	0	0	0	1	0	0	0	8668	854	30	2	752	2	LARP4	12	50834308	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	921407	50834308	83017587	55	9537										
ACSS3	79611	broad.mit.edu	37	chr12	81471942	81471942	+	Frame_Shift_Del	DEL	G	G	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gtcgtaaagtcaccagcgccGgggggctcggagggcccttg							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr12:81471942delG	ENST00000548058.1	+	1	953	c.43delG	c.(43-45)ggfs	p.G16fs	ACSS3_ENST00000261206.3_Frame_Shift_Del_p.G16fs			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	16						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CACCAGCGCCGGGGGGCTCGG	0.697													2	4	---	---	---	---						-	81471942	G	-	81471942	7	5	57	1	0	1	0	1	0	0	0	0	190	1116	39	0	45	0	ACSS3	12	81471942	Frame_Shift_Del	DEL	G	TCGA-QN-A5NN-01A-11D-A28R-08	30637634	81471942	52379953	56	9538										
WDR66	144406	broad.mit.edu	37	chr12	122361824	122361824	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tccaaagcagggatctcccgGgagtcactggtgtccagcac	12	13	2	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr12:122361824G>T	ENST00000288912.4	+	3	1529	c.675G>T	c.(673-675)cgG>cgT	p.R225R	WDR66_ENST00000397454.2_Silent_p.R225R	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	225							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GGATCTCCCGGGAGTCACTGG	0.493													25	52					1.64293e-13	1.71068e-13	1	1	0	T	122361824	G	T	122361824	2	4	57	1	0	0	0	0	0	0	0	1	17376	1219	43	5		5	WDR66	12	122361824	Silent	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	40889882	122361824	11490071	57	9539										
OR11H6	122748	broad.mit.edu	37	chr14	20692036	20692036	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ctggttctctatctcctgacActgctagggaatggagctat	10	10	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr14:20692036A>G	ENST00000315519.2	+	1	246	c.168A>G	c.(166-168)acA>acG	p.T56T		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		ATCTCCTGACACTGCTAGGGA	0.478													15	60					0	0	1	0	0	G	20692036	A	G	20692036	2	3	57	1	0	0	0	0	0	0	0	1	10976	146	6	4		4	OR11H6	14	20692036	Silent	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		20692036	86657504	58	9540										
YLPM1	56252	broad.mit.edu	37	chr14	75265354	75265354	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ggaccacctcggagggctggCagtcaggagaggggacctct	17	11	2	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr14:75265354C>T	ENST00000325680.7	+	5	3478	c.3354C>T	c.(3352-3354)ggC>ggT	p.G1118G	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Silent_p.G923G	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	923	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GGAGGGCTGGCAGTCAGGAGA	0.642													29	23					0	0	1	0	0	T	75265354	C	T	75265354	2	4	57	1	0	0	0	0	0	0	0	1	17545	697	25	3		3	YLPM1	14	75265354	Silent	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	54573318	75265354	32084186	59	9541										
TMCO5A	145942	broad.mit.edu	37	chr15	38229143	38229143	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ggaaagggaaagagccttgcAggagctggaggaagaaacag	17	5	0	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr15:38229143A>C	ENST00000558158.1	+	4	390	c.236A>C	c.(235-237)cAg>cCg	p.Q79P	TMCO5A_ENST00000319669.4_Missense_Mutation_p.Q79P|TMCO5A_ENST00000540944.1_Missense_Mutation_p.Q79P|TMCO5A_ENST00000559502.1_Missense_Mutation_p.Q79P			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	79						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						AGAGCCTTGCAGGAGCTGGAG	0.488													24	6					0	0	1	0	0	C	38229143	A	C	38229143	3	2	57	1	0	0	0	0	1	0	0	0	16058	188	7	4	242	4	TMCO5A	15	38229143	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		38229143	64302249	60	9542										
WDR72	256764	broad.mit.edu	37	chr15	53957934	53957934	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	caattaagaataattcgtgcTctttctcctgtctcatgtct	5	10	4	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr15:53957934T>C	ENST00000396328.1	-	14	2036	c.1797A>G	c.(1795-1797)agA>agG	p.R599R	WDR72_ENST00000557913.1_Silent_p.R596R|WDR72_ENST00000360509.5_Silent_p.R599R|WDR72_ENST00000559418.1_Silent_p.R609R	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	599										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TAATTCGTGCTCTTTCTCCTG	0.373													23	8					0	0	1	0	0	C	53957934	T	C	53957934	2	2	57	1	0	0	0	0	0	0	0	1	17381	1548	54	4		4	WDR72	15	53957934	Silent	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	15728791	53957934	48573458	61	9543										
ABCC1	4363	broad.mit.edu	37	chr16	16149958	16149958	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tctcttccaaggtggcccacAtgaagagcaaagacaatcgg	10	11	1	3			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr16:16149958A>G	ENST00000399408.2	+	12	1658	c.1483A>G	c.(1483-1485)Atg>Gtg	p.M495V	ABCC1_ENST00000349029.5_Missense_Mutation_p.M495V|ABCC1_ENST00000346370.5_Missense_Mutation_p.M495V|ABCC1_ENST00000351154.5_Missense_Mutation_p.M495V|ABCC1_ENST00000345148.5_Missense_Mutation_p.M495V|ABCC1_ENST00000399410.3_Missense_Mutation_p.M495V			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	495	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTGGCCCACATGAAGAGCAA	0.473													11	41					0	0	1	0	0	G	16149958	A	G	16149958	3	3	57	1	0	0	0	0	1	0	0	0	49	217	8	4	1529	4	ABCC1	16	16149958	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		16149958	74204795	62	9544										
GP2	2813	broad.mit.edu	37	chr16	20331092	20331092	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	tggcatgggtttgatttctcTttggcaaaaaaacaaaacca	8	7	1	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr16:20331092T>C	ENST00000302555.5	-	6	1008		c.e6-2		GP2_ENST00000381362.4_Splice_Site|GP2_ENST00000341642.5_Splice_Site|GP2_ENST00000573897.1_Splice_Site|GP2_ENST00000381360.5_Splice_Site			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)							anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TTGATTTCTCTTTGGCAAAAA	0.388													56	56					0	0	1	0	0	C	20331092	T	C	20331092	5	2	57	1	0	0	0	0	0	0	1	0	6621	1623	56	4	771	4	GP2	16	20331092	Splice_Site	SNP	T	TCGA-QN-A5NN-01A-11D-A28R-08	4181134	20331092	70023661	63	9545										
SULT1A1	6817	broad.mit.edu	37	chr16	28618359	28618359	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gtggtagaagtggtagtaggAaactgccacatcctttgcgt	13	7	0	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr16:28618359A>T	ENST00000395609.1	-	7	1170	c.412T>A	c.(412-414)Tcc>Acc	p.S138T	SULT1A1_ENST00000569554.1_Missense_Mutation_p.S138T|SULT1A1_ENST00000395607.1_Missense_Mutation_p.S138T|SULT1A1_ENST00000314752.7_Missense_Mutation_p.S138T|SULT1A1_ENST00000350842.4_Missense_Mutation_p.S60T			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	138					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						TGGTAGTAGGAAACTGCCACA	0.582													36	119					0	0	1	0	0	T	28618359	A	T	28618359	3	4	57	1	0	0	0	0	1	0	0	0	15427	246	9	4	491	4	SULT1A1	16	28618359	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	8287267	28618359	61736394	64	9546										
DOC2A	8448	broad.mit.edu	37	chr16	30021385	30021385	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gccagggggaccagatgggcGggggcctccccgccgccccc	17	18	0	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr16:30021385G>A	ENST00000350119.4	-	2	349	c.159C>T	c.(157-159)ccC>ccT	p.P53P	DOC2A_ENST00000564944.1_Silent_p.P53P|DOC2A_ENST00000564979.1_Silent_p.P53P	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	53	Interaction with UNC13D and DYNLT1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						CCAGATgggcgggggcctccc	0.721													31	22					0	0	1	0	0	A	30021385	G	A	30021385	2	1	57	1	0	0	0	0	0	0	0	1	4710	1103	39	1		1	DOC2A	16	30021385	Silent	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	1403026	30021385	60333368	65	9547										
ANKRD11	29123	broad.mit.edu	37	chr16	89351717	89351728	+	In_Frame_Del	DEL	CGACGTGTCTGA	CGACGTGTCTGA	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	acactcgcgtcctcctcgtcCgacgtgtctgacaggatacg							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr16:89351717_89351728delCGACGTGTCTGA	ENST00000301030.4	-	9	1682_1693	c.1222_1233delTCAGACACGTCG	c.(1222-1233)del	p.SDTS408del	ANKRD11_ENST00000378330.2_In_Frame_Del_p.SDTS408del	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	408						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTCCTCGTCCGACGTGTCTGACAGGATACGA	0.462													22	33	---	---	---	---						-	89351728	CGACGTGTCTGA	-	89351717	7	5	57	1	0	1	0	1	0	0	0	0	635	639	23	0	6778	0	ANKRD11	16	89351717	In_Frame_Del	DEL	CGACGTGTCTGA	TCGA-QN-A5NN-01A-11D-A28R-08	59330332	89351717	1003036	66	9548										
TP53	7157	broad.mit.edu	37	chr17	7577559	7577559	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ggttcatgccgcccatgcagGaactgttacacatgtagttg	11	10	1	0	rs28934573		TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr17:7577559G>T	ENST00000420246.2	-	7	854	c.722C>A	c.(721-723)tCc>tAc	p.S241Y	TP53_ENST00000269305.4_Missense_Mutation_p.S241Y|TP53_ENST00000413465.2_Missense_Mutation_p.S241Y|TP53_ENST00000445888.2_Missense_Mutation_p.S241Y|TP53_ENST00000359597.4_Missense_Mutation_p.S241Y|TP53_ENST00000455263.2_Missense_Mutation_p.S241Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572		111	"Mis, N, F"		"breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"	"breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	6					6.97489e-18	7.49429e-18	1	1	0	T	7577559	G	T	7577559	3	4	57	1	0	0	0	0	1	0	0	0	16441	1174	41	2	568	2	TP53	17	7577559	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		7577559	73617651	67	9549										
NF1	4763	broad.mit.edu	37	chr17	29528441	29528441	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ttctatagatctgcctggctCagaattcaccttctacattt	5	11	5	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr17:29528441C>T	ENST00000358273.4	+	11	1581	c.1198C>T	c.(1198-1200)Cag>Tag	p.Q400*	NF1_ENST00000356175.3_Nonsense_Mutation_p.Q400*|NF1_ENST00000431387.4_Nonsense_Mutation_p.Q400*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	400					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)|p.Q400*(2)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTGCCTGGCTCAGAATTCACC	0.308			"D, Mis, N, F, S, O"		"neurofibroma, glioma"	"neurofibroma, glioma"			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			43	13					0	0	1	0	0	T	29528441	C	T	29528441	4	4	57	1	0	0	0	0	0	1	0	0	10402	827	29	3	1240	3	NF1	17	29528441	Nonsense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	21950882	29528441	51666769	68	9550										
OR4D2	124538	broad.mit.edu	37	chr17	56247337	56247337	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	atcttcttcttccactttttGggaggtgccatggtcttctt	8	10	5	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr17:56247337G>T	ENST00000545221.1	+	1	321	c.321G>T	c.(319-321)ttG>ttT	p.L107F		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						TCCACTTTTTGGGAGGTGCCA	0.527													61	15					5.7761e-15	6.14091e-15	1	1	0	T	56247337	G	T	56247337	3	4	57	1	0	0	0	0	1	0	0	0	11103	1339	47	5	323	5	OR4D2	17	56247337	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	26718896	56247337	24947873	69	9551										
ZBTB7C	201501	broad.mit.edu	37	chr18	45556036	45556036	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	agcaggctggcggccctccaCgcagcaggcttgcggccgcg	16	16	0	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr18:45556036C>T	ENST00000588982.1	-	4	1956	c.1455G>A	c.(1453-1455)gcG>gcA	p.A485A	ZBTB7C_ENST00000535628.2_Silent_p.A485A|ZBTB7C_ENST00000590800.1_Silent_p.A485A|ZBTB7C_ENST00000586438.1_Silent_p.A485A|ZBTB7C_ENST00000332053.2_Silent_p.A485A			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	485						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CGGCCCTCCACGCAGCAGGCT	0.736													6	1					0	0	1	0	0	T	45556036	C	T	45556036	2	4	57	1	0	0	0	0	0	0	0	1	17613	523	19	1		1	ZBTB7C	18	45556036	Silent	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08		45556036	32521212	70	9552										
NFATC1	4772	broad.mit.edu	37	chr18	77171011	77171011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ccacctcgccccgcgccagcGtcactgaggagagctggctg	13	17	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr18:77171011G>A	ENST00000253506.5	+	2	1105	c.736G>A	c.(736-738)Gtc>Atc	p.V246I	NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000587635.1_Missense_Mutation_p.V246I|NFATC1_ENST00000329101.4_Missense_Mutation_p.V233I|NFATC1_ENST00000591814.1_Missense_Mutation_p.V246I|NFATC1_ENST00000586434.1_Missense_Mutation_p.V233I|NFATC1_ENST00000592223.1_Missense_Mutation_p.V233I|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000542384.1_Missense_Mutation_p.V246I|NFATC1_ENST00000427363.2_Missense_Mutation_p.V246I|NFATC1_ENST00000318065.5_Missense_Mutation_p.V233I	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	246	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.V233I(1)		NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCGCGCCAGCGTCACTGAGGA	0.711													25	8					0	0	1	0	0	A	77171011	G	A	77171011	3	1	57	1	0	0	0	0	1	0	0	0	10407	1145	40	1	834	1	NFATC1	18	77171011	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	31614975	77171011	906237	71	9553										
ECSIT	51295	broad.mit.edu	37	chr19	11624812	11624812	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	agggccaggtagatgaagtcAatgtggccccgcttacgcac	13	11	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr19:11624812A>C	ENST00000270517.7	-	3	456	c.321T>G	c.(319-321)atT>atG	p.I107M	ECSIT_ENST00000592312.1_De_novo_Start_InFrame|ECSIT_ENST00000591104.1_Missense_Mutation_p.I107M|ECSIT_ENST00000588998.1_Intron|ECSIT_ENST00000252440.7_Missense_Mutation_p.I107M|ECSIT_ENST00000417981.2_Intron	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	107					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						AGATGAAGTCAATGTGGCCCC	0.602													66	17					0	0	1	0	0	C	11624812	A	C	11624812	3	2	57	1	0	0	0	0	1	0	0	0	4926	126	5	4	998	4	ECSIT	19	11624812	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08		11624812	47504171	72	9554										
ATF5	22809	broad.mit.edu	37	chr19	50436066	50436068	+	In_Frame_Del	DEL	CTT	CTT	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gccacagcagccccctcctcCttctccacctcaaccttctc							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr19:50436066_50436068delCTT	ENST00000423777.2	+	3	943_945	c.566_568delCTT	c.(565-570)cct>c	p.PS189del	ATF5_ENST00000595125.1_In_Frame_Del_p.PS189del|CTC-326K19.6_ENST00000451973.1_Intron	NM_001193646.1	NP_001180575.1	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	189	Interaction with PTP4A1 (By similarity).|Poly-Pro.				regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			NS(1)|endometrium(2)|large_intestine(1)|skin(3)	7		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCCCCTCCTCCTTCTCCACCTCA	0.64													11	18	---	---	---	---						-	50436068	CTT	-	50436066	7	5	57	1	0	1	0	1	0	0	0	0	1082	681	24	0	572	0	ATF5	19	50436066	In_Frame_Del	DEL	CTT	TCGA-QN-A5NN-01A-11D-A28R-08	38811254	50436066	8692917	73	9555										
PRKCG	5582	broad.mit.edu	37	chr19	54410111	54410111	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	acttcgtgcacccggatgccCgcagccccaccagcccagtg	10	19	0	0			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr19:54410111C>T	ENST00000263431.3	+	18	2338	c.2056C>T	c.(2056-2058)Cgc>Tgc	p.R686C	PRKCG_ENST00000540413.1_Missense_Mutation_p.R686C|PRKCG_ENST00000542049.1_Missense_Mutation_p.R537C	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	686					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCCGGATGCCCGCAGCCCCAC	0.682											OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	82					0	0	1	0	0	T	54410111	C	T	54410111	3	4	57	1	0	0	0	0	1	0	0	0	12563	652	23	1	2126	1	PRKCG	19	54410111	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	3974045	54410111	4718872	74	9556										
BRSK1	84446	broad.mit.edu	37	chr19	55816083	55816083	+	Frame_Shift_Del	DEL	C	C	-													0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cgctccacacccctgcccggCcccccaggctccccgcgctc							TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr19:55816083delC	ENST00000309383.1	+	14	1789	c.1512delC	c.(1510-1512)ggfs	p.G504fs	BRSK1_ENST00000590333.1_Frame_Shift_Del_p.G520fs|BRSK1_ENST00000326848.7_Frame_Shift_Del_p.G199fs|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	504	Pro-rich.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCCTGCCCGGCCCCCCAGGCT	0.771													3	3	---	---	---	---						-	55816083	C	-	55816083	7	5	57	1	0	1	0	1	0	0	0	0	1525	726	26	0	1566	0	BRSK1	19	55816083	Frame_Shift_Del	DEL	C	TCGA-QN-A5NN-01A-11D-A28R-08	1405972	55816083	3312900	75	9557										
VPS16	64601	broad.mit.edu	37	chr20	2842328	2842328	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	aaaggcggctgatggtggtgGgcgatgcacccgagagcatc	17	9	0	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr20:2842328G>A	ENST00000380445.3	+	9	949	c.877G>A	c.(877-879)Ggc>Agc	p.G293S	VPS16_ENST00000481812.2_3'UTR|VPS16_ENST00000380469.3_Missense_Mutation_p.G293S	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	293					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						GATGGTGGTGGGCGATGCACC	0.622													6	13					0	0	1	0	0	A	2842328	G	A	2842328	3	1	57	1	0	0	0	0	1	0	0	0	17252	1232	43	3	911	3	VPS16	20	2842328	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		2842328	60183192	76	9558										
CTSZ	1522	broad.mit.edu	37	chr20	57571752	57571752	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cagtcccatcactgatgcccCacccagccacagaaacgaca	6	18	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr20:57571752C>A	ENST00000217131.5	-	5	861	c.743G>T	c.(742-744)tGg>tTg	p.W248L		NM_001336.3	NP_001327.2	Q9UBR2	CATZ_HUMAN	cathepsin Z	248					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	10	all_lung(29;0.00711)		Colorectal(105;0.109)			ACTGATGCCCCACCCAGCCAC	0.448													26	52					1.1804e-14	1.24188e-14	1	1	0	A	57571752	C	A	57571752	3	1	57	1	0	0	0	0	1	0	0	0	4067	595	21	5	176	5	CTSZ	20	57571752	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	54729424	57571752	5453768	77	9559										
LAMA5	3911	broad.mit.edu	37	chr20	60901785	60901785	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	ggccaggcgtggggtatgccGgctccaggaatgtgatgctc	17	10	0	1	rs149220558	byFrequency	TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr20:60901785G>A	ENST00000252999.3	-	40	5312	c.5246C>T	c.(5245-5247)cCg>cTg	p.P1749L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1749	Laminin IV type A.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGTATGCCGGCTCCAGGAA	0.672													26	48					0	0	1	0	0	A	60901785	G	A	60901785	3	1	57	1	0	0	0	0	1	0	0	0	8647	1116	39	1	6005	1	LAMA5	20	60901785	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	3330033	60901785	2123735	78	9560										
LAMA5	3911	broad.mit.edu	37	chr20	60927360	60927360	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gcagatggccgcgtcgtcccGtgtgatgcgctccagcgtct	14	14	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr20:60927360G>C	ENST00000252999.3	-	4	691	c.625C>G	c.(625-627)Cgg>Ggg	p.R209G	LAMA5_ENST00000370677.3_Missense_Mutation_p.R209G|LAMA5_ENST00000370692.3_Missense_Mutation_p.R209G	NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	209	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGTCGTCCCGTGTGATGCGC	0.687													6	17					0	0	1	0	0	C	60927360	G	C	60927360	3	2	57	1	0	0	0	0	1	0	0	0	8647	1144	40	5	10770	5	LAMA5	20	60927360	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08	25575	60927360	2098160	79	9561										
BAGE2	85319	broad.mit.edu	37	chr21	11058322	11058322	+	RNA	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	agtgcttacaaaatgcacatCgctgaaaggggtaaaggaga	12	6	0	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chr21:11058322C>T	ENST00000470054.1	-	0	325									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAATGCACATCGCTGAAAGGG	0.383													4	104					0	0	1	0	0	T	11058322	C	T	11058322	1	4	57	0	1	0	0	0	0	0	0	0	1290	898	31	1		1	BAGE2	21	11058322	RNA	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08		11058322	37071573	80	9562										
PHKA2	5256	broad.mit.edu	37	chrX	18929042	18929042	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gattcagtgatttacggtggGcacttagaactttagtcggc	12	7	1	2			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chrX:18929042G>C	ENST00000379942.4	-	20	2839	c.2174C>G	c.(2173-2175)gCc>gGc	p.A725G		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	725					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					TTTACGGTGGGCACTTAGAAC	0.358													62	20					0	0	1	0	0	C	18929042	G	C	18929042	3	2	57	1	0	0	0	0	1	0	0	0	11891	1203	42	5	1589	5	PHKA2	23	18929042	Missense_Mutation	SNP	G	TCGA-QN-A5NN-01A-11D-A28R-08		18929042	136341518	81	9563										
CCDC22	28952	broad.mit.edu	37	chrX	49098537	49098537	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	cttcctctaccccagtgagcCtgacctccgagacctgcttc	7	18	1	3			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chrX:49098537C>G	ENST00000376227.3	+	3	454	c.284C>G	c.(283-285)cCt>cGt	p.P95R	CCDC22_ENST00000496651.1_3'UTR	NM_014008.3	NP_054727.1	O60826	CCD22_HUMAN	coiled-coil domain containing 22	95										NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	18						CCCAGTGAGCCTGACCTCCGA	0.607													31	8					0	0	1	0	0	G	49098537	C	G	49098537	3	3	57	1	0	0	0	0	1	0	0	0	2816	681	24	5	294	5	CCDC22	23	49098537	Missense_Mutation	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	30169495	49098537	106172023	82	9564										
TRO	7216	broad.mit.edu	37	chrX	54955077	54955077	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gactgggctgtgcagtaccgCgaggcagtggagatggaagt	18	7	0	1			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chrX:54955077C>T	ENST00000173898.7	+	12	2032	c.1920C>T	c.(1918-1920)cgC>cgT	p.R640R	TRO_ENST00000399736.1_Silent_p.R243R|TRO_ENST00000375022.4_Silent_p.R640R|TRO_ENST00000375041.2_Silent_p.R243R|TRO_ENST00000420798.2_Silent_p.R171R|TRO_ENST00000319167.8_Silent_p.R640R	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	640	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						TGCAGTACCGCGAGGCAGTGG	0.512													37	5					0	0	1	0	0	T	54955077	C	T	54955077	2	4	57	1	0	0	0	0	0	0	0	1	16634	755	27	1		1	TRO	23	54955077	Silent	SNP	C	TCGA-QN-A5NN-01A-11D-A28R-08	5856540	54955077	100315483	83	9565										
ARHGAP36	158763	broad.mit.edu	37	chrX	130220396	130220396	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0357142857142857	3	1	0.510802469135803	0.851337448559671	0.425668724279835	1	1	0	gacgcaggaacttgaggaagAtccagtgagtgttttttggg	15	5	0	3			TCGA-QN-A5NN-01A-11D-A28R-08	TCGA-QN-A5NN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abcd4890-6e74-475f-aa72-07c9da4ee26d	4ebb48b7-7795-477b-86b2-85ad659c3abe	g.chrX:130220396A>T	ENST00000276211.5	+	10	1720	c.1375A>T	c.(1375-1377)Atc>Ttc	p.I459F	ARHGAP36_ENST00000370922.1_Missense_Mutation_p.I447F|ARHGAP36_ENST00000370921.1_Missense_Mutation_p.I323F	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	459					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						CTTGAGGAAGATCCAGTGAGT	0.473													11	31					0	0	1	0	0	T	130220396	A	T	130220396	3	4	57	1	0	0	0	0	1	0	0	0	880	333	12	4	1409	4	ARHGAP36	23	130220396	Missense_Mutation	SNP	A	TCGA-QN-A5NN-01A-11D-A28R-08	75265319	130220396	25050164	84	9566										
